Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AKR1B15	441282	broad.mit.edu	37	7	134260255	134260255	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr7:134260255G>T	uc011kpr.2	+	6	896	c.597G>T	c.(595-597)ttG>ttT	p.L199F		NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	Homo sapiens aldo-keto reductase family 1, member B15 (AKR1B15), mRNA.	199							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						AGAGGCTCTTGAACAAACCTG	0.463000														137			83		5.01443e-46	2.17893e-44	0.000781405	1	0
MBD6	114785	broad.mit.edu	37	12	57918527	57918527	+	Silent	SNP	C	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr12:57918527C>A	uc001soj.1	+	3	362	c.138C>A	c.(136-138)tcC>tcA	p.S46S	MBD6_uc001sok.1_5'Flank|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	Homo sapiens methyl-CpG binding domain protein 6 (MBD6), mRNA.	46	MBD.					chromosome|nucleus	DNA binding|chromatin binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						AGCTGTCTTCCTTGGAGCAAA	0.572000														71			39		1.03484e-13	4.11284e-12	0.000191422	1	0
TDRD5	163589	broad.mit.edu	37	1	179621298	179621298	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr1:179621298G>T	uc010pnp.2	+	12	2644	c.2126G>T	c.(2125-2127)aGt>aTt	p.S709I	TDRD5_uc021pfm.1_Missense_Mutation_p.S709I|TDRD5_uc001gnf.2_Missense_Mutation_p.S709I|TDRD5_uc021pfn.1_Missense_Mutation_p.S709I|TDRD5_uc001gnh.2_Missense_Mutation_p.S264I	NM_001199085	NP_001186014	Q8NAT2	TDRD5_HUMAN	Homo sapiens tudor domain containing 5 (TDRD5), transcript variant 1, mRNA.	709					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CGAAAGATAAGTCCACAGTCA	0.368000														59			4		0.00024832	0.00930201	0.00024832	1	0
HPS5	11234	broad.mit.edu	37	11	18309441	18309441	+	Splice_Site	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr11:18309441G>A	uc001mod.1	-	17	2839	c.2561_splice	c.e17+1	p.R854_splice	HPS5_uc001moe.1_Splice_Site_p.R740_splice|HPS5_uc001mof.1_Splice_Site_p.R740_splice	NM_181507	NP_852609	Q9UPZ3	HPS5_HUMAN	Homo sapiens Hermansky-Pudlak syndrome 5 (HPS5), transcript variant 1, mRNA.	854						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						ACAACTTACCGGGTAGCATAA	0.363000									Hermansky-Pudlak syndrome					25			21		0	0	0.000132079	0	0
ZNF254	9534	broad.mit.edu	37	19	24310237	24310237	+	Nonsense_Mutation	SNP	A	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr19:24310237A>T	uc002nru.3	+	3	1569	c.1435A>T	c.(1435-1437)Aga>Tga	p.R479*	ZNF254_uc010xrk.2_Nonsense_Mutation_p.R394*	NM_203282	NP_975011	O75437	ZN254_HUMAN	Homo sapiens zinc finger protein 254 (ZNF254), mRNA.	479					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AACCCTAACTAGACATAAGAG	0.388000														47			15		0	0	0.00074312	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2408353	2408353	+	Splice_Site	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr19:2408353G>A	uc010xgx.2	+	7	741	c.741_splice	c.e7-1	p.E247_splice	TMPRSS9_uc002lvv.1_Splice_Site_p.E281_splice	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	Homo sapiens transmembrane protease, serine 9 (TMPRSS9), mRNA.	247	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGCTCCTGCAGGTTCCAAGAC	0.652000														43			5		0	0	8.12818e-05	0	0
CC2D1B	200014	broad.mit.edu	37	1	52819228	52819228	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr1:52819228G>C	uc001ctq.2	-	23	2691	c.2540C>G	c.(2539-2541)aCt>aGt	p.T847S	CC2D1B_uc001ctr.3_Missense_Mutation_p.T387S|CC2D1B_uc001cts.3_Intron	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	Homo sapiens coiled-coil and C2 domain containing 1B (CC2D1B), mRNA.	847										breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						CCAGTTCTCAGTGACCATCTG	0.592000														22			15		0	0	0.000958276	0	0
PHF12	57649	broad.mit.edu	37	17	27251080	27251080	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:27251080T>A	uc002hdg.1	-	3	1092	c.562A>T	c.(562-564)Att>Ttt	p.I188F	PHF12_uc010wbb.1_Missense_Mutation_p.I170F|PHF12_uc002hdi.1_Missense_Mutation_p.I184F|PHF12_uc002hdj.1_Missense_Mutation_p.I188F|PHF12_uc010crw.1_Intron|BC033997_uc002hdl.3_5'Flank|PHF12_uc002hdh.1_5'UTR	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	Homo sapiens PHD finger protein 12 (PHF12), transcript variant 1, mRNA.	188	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TCCACGTCAATGATGTCTTCG	0.602000														30			43		0	0	0.000781405	0	0
MED1	5469	broad.mit.edu	37	17	37565701	37565701	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:37565701G>T	uc002hrv.4	-	16	2985	c.2773C>A	c.(2773-2775)Caa>Aaa	p.Q925K	MED1_uc010wee.2_Missense_Mutation_p.Q753K|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	Homo sapiens mediator complex subunit 1 (MED1), mRNA.	925	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		GTGTCGGCTTGGTTATTGCCC	0.438000										HNSCC(31;0.082)				260			9		3.86212e-05	0.00146356	0.000673444	1	0
RDH5	5959	broad.mit.edu	37	12	56118170	56118170	+	Silent	SNP	A	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr12:56118170A>T	uc001shk.3	+	4	981	c.798A>T	c.(796-798)cgA>cgT	p.R266R	RDH5_uc021qyt.1_Silent_p.R129R|RDH5_uc001shl.3_Silent_p.R266R	NM_002905	NP_002896	Q92781	RDH1_HUMAN	Homo sapiens retinol dehydrogenase 5 (11-cis/9-cis) (RDH5), transcript variant 2, mRNA.	266					response to stimulus|visual perception	membrane	binding|retinol dehydrogenase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|skin(1)	12					NADH(DB00157)|Vitamin A(DB00162)	AGGTGAGCCGATGCCTGGAGC	0.592000											OREG0021908	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		81			33		0	0	0.000339439	0	0
ZNF471	57573	broad.mit.edu	37	19	57037032	57037032	+	Silent	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr19:57037032A>G	uc002qnh.3	+	4	1729	c.1596A>G	c.(1594-1596)caA>caG	p.Q532Q		NM_020813	NP_065864	Q9BX82	ZN471_HUMAN	Homo sapiens zinc finger protein 471 (ZNF471), mRNA.	532					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(8)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		ACCTTGCCCAACATCAGAAAA	0.398000														65			34		0	0	0.00058488	0	0
NPAT	4863	broad.mit.edu	37	11	108032024	108032024	+	Silent	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr11:108032024A>G	uc001pjz.4	-	16	3891	c.3789T>C	c.(3787-3789)agT>agC	p.S1263S	NPAT_uc010rvv.2_Silent_p.S319S	NM_002519	NP_002510	Q14207	NPAT_HUMAN	Homo sapiens nuclear protein, ataxia-telangiectasia locus (NPAT), mRNA.	1263					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity	p.S1262S(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(21)|ovary(2)|prostate(2)|skin(5)	46		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		CAGGTAAATCACTACTATCAG	0.443000														75			51		0	0	0.000781405	0	0
ATAD2B	54454	broad.mit.edu	37	2	24051776	24051776	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:24051776C>A	uc002rek.4	-	14	2058	c.1762G>T	c.(1762-1764)Gac>Tac	p.D588Y	ATAD2B_uc002rei.4_Missense_Mutation_p.D588Y|ATAD2B_uc010yki.2_Non-coding_Transcript|ATAD2B_uc002rej.4_5'UTR	NM_017552	NP_060022	Q9ULI0	ATD2B_HUMAN	Homo sapiens ATPase family, AAA domain containing 2B (ATAD2B), transcript variant 1, mRNA.	588							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATTCCAGTCCCTGGTATGG	0.333000														62			51		1.57914e-17	6.51447e-16	0.000781405	1	0
UBR1	197131	broad.mit.edu	37	15	43299382	43299382	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr15:43299382C>T	uc001zqq.3	-	29	3376	c.3310G>A	c.(3310-3312)Gaa>Aaa	p.E1104K		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 1 (UBR1), mRNA.	1104					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ACCTCCTGTTCTTCTTGGCAA	0.473000														77			42		0	0	0.000680045	0	0
TNS1	7145	broad.mit.edu	37	2	218713795	218713795	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:218713795G>A	uc002vgt.2	-	16	1468	c.1070C>T	c.(1069-1071)aCg>aTg	p.T357M	TNS1_uc002vgr.2_Missense_Mutation_p.T357M|TNS1_uc002vgs.2_Missense_Mutation_p.T357M|TNS1_uc010zjv.1_Missense_Mutation_p.T357M|TNS1_uc010fvj.1_Missense_Mutation_p.T425M|TNS1_uc010fvk.1_Missense_Mutation_p.T482M|TNS1_uc010fvi.1_Missense_Mutation_p.T44M	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	Homo sapiens tensin 1 (TNS1), mRNA.	357						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGCCCCTGCGTGTGTCCCAC	0.577000														131			34		0	0	0.000491102	0	0
BPIFA2	140683	broad.mit.edu	37	20	31761923	31761923	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr20:31761923C>T	uc002wyo.1	+	3	412	c.341C>T	c.(340-342)gCt>gTt	p.A114V		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	Homo sapiens BPI fold containing family A, member 2 (BPIFA2), mRNA.	114						extracellular region	lipid binding										GATGTCAAAGCTGAACCGATC	0.507000														75			27		0	0	0.000491102	0	0
ROBO2	6092	broad.mit.edu	37	3	77542437	77542437	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr3:77542437T>G	uc011bgk.2	+	4	1353	c.710T>G	c.(709-711)cTg>cGg	p.L237R	ROBO2_uc021xat.1_Missense_Mutation_p.L253R|ROBO2_uc003dpy.4_Missense_Mutation_p.L237R|ROBO2_uc003dpz.3_Missense_Mutation_p.L237R|ROBO2_uc011bgj.2_Non-coding_Transcript	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	Homo sapiens roundabout, axon guidance receptor, homolog 2 (Drosophila) (ROBO2), transcript variant 2, mRNA.	237	Ig-like C2-type 3.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding	p.V236L(1)		NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGGTGGTACTGGAGGAAGAA	0.403000														78			5		0	0	3.59834e-05	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20491913	20491913	+	Nonsense_Mutation	SNP	A	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr20:20491913A>T	uc002wrz.3	-	32	5056	c.4913T>A	c.(4912-4914)tTg>tAg	p.L1638*	RALGAPA2_uc002wry.3_Nonsense_Mutation_p.L1253*|RALGAPA2_uc010zsg.2_Nonsense_Mutation_p.L1086*|RALGAPA2_uc002wsa.1_Nonsense_Mutation_p.L410*	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	Homo sapiens Ral GTPase activating protein, alpha subunit 2 (catalytic) (RALGAPA2), mRNA.	1638	Rap-GAP.				activation of Ral GTPase activity	cytosol|nucleus	Ral GTPase activator activity|protein heterodimerization activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						GCGGGAGTCCAAATTTTTCAG	0.328000														9			9		0	0	0.000673444	0	0
LOC642846	642846	broad.mit.edu	37	12	9453702	9453702	+	RNA	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr12:9453702C>T	uc001qvp.2	+	0		c.13C>T			LOC642846_uc010sgp.1_Non-coding_Transcript					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11-like (LOC642846), non-coding RNA.									p.P370S(2)									GGTGGTGCTGCCCTATCAGAT	0.662000														6			4		0	0	0.000602214	0	0
BC007896	0	broad.mit.edu	37	16	67184131	67184131	+	Nonstop_Mutation	SNP	G	C	C			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr16:67184131G>C	uc002erg.1	+	0	1013	c.534G>C	c.(532-534)taG>taC	p.*178Y	B3GNT9_uc002erf.3_Silent_p.R86R|B3GNT9_uc021tka.1_Silent_p.R86R					Homo sapiens cDNA clone IMAGE:3530459, **** WARNING: chimeric clone ****.																		CGCGCAAATAGCGGGCGAAGT	0.706000														9			5		0	0	0.000602214	0	0
OR1E1	8387	broad.mit.edu	37	17	3301701	3301701	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:3301701T>C	uc002fvj.1	-	0	4	c.4A>G	c.(4-6)Atg>Gtg	p.M2V		NM_003553	NP_003544	P30953	OR1E1_HUMAN	Homo sapiens olfactory receptor, family 1, subfamily E, member 1 (OR1E1), mRNA.	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(2)|lung(5)	10						TTTTGTCCCATCATGCTCTGT	0.438000														165			3		0	0	6.4e-05	0	0
LAP3	51056	broad.mit.edu	37	4	17586652	17586652	+	Silent	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr4:17586652A>G	uc003gph.1	+	5	759	c.597A>G	c.(595-597)gcA>gcG	p.A199A	LAP3_uc010ieg.3_3'UTR	NM_015907	NP_056991	P28838	AMPL_HUMAN	Homo sapiens leucine aminopeptidase 3 (LAP3), mRNA.	199					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|urinary_tract(1)	20						AGAACTTGGCACGCCAATTGA	0.478000														59			16		0	0	0.000958276	0	0
DYM	54808	broad.mit.edu	37	18	46645145	46645145	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr18:46645145G>A	uc002ldi.1	-	14	2080	c.1715C>T	c.(1714-1716)tCa>tTa	p.S572L	DYM_uc010xdf.1_Missense_Mutation_p.S382L|DYM_uc002ldj.3_Missense_Mutation_p.S394L	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	Homo sapiens dymeclin (DYM), mRNA.	572						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						ATCCTGAAATGAAGGATGAGT	0.353000														42			20		0	0	0.000175454	0	0
OXR1	55074	broad.mit.edu	37	8	107718929	107718929	+	Silent	SNP	T	C	C			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr8:107718929T>C	uc011lht.2	+	7	1282	c.1183T>C	c.(1183-1185)Tta>Cta	p.L395L	OXR1_uc022azp.1_Silent_p.L394L|OXR1_uc003ymf.3_Silent_p.L394L|OXR1_uc011lhu.2_Silent_p.L387L|OXR1_uc010mcg.3_Intron|OXR1_uc010mch.3_Silent_p.L92L|OXR1_uc003ymg.1_Silent_p.L327L|OXR1_uc003ymi.1_Silent_p.L306L	NM_001198532	NP_001185461	Q8N573	OXR1_HUMAN	Homo sapiens oxidation resistance 1 (OXR1), transcript variant 3, mRNA.	395					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TCCTGGTCACTTAAGATCTGA	0.368000														48			17		0	0	0.00074312	0	0
SSTR4	6754	broad.mit.edu	37	20	23017198	23017198	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr20:23017198A>T	uc002wsr.2	+	0	1142	c.1078A>T	c.(1078-1080)Atg>Ttg	p.M360L		NM_001052	NP_001043	P31391	SSR4_HUMAN	Homo sapiens somatostatin receptor 4 (SSTR4), mRNA.	360					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GGCAGGGTGCATGTGCCCCCC	0.657000														90			6		0	0	3.59834e-05	0	0
GJC1	10052	broad.mit.edu	37	17	42882624	42882624	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:42882624C>G	uc002ihj.3	-	1	1073	c.562G>C	c.(562-564)Gag>Cag	p.E188Q	GJC1_uc002ihk.3_Missense_Mutation_p.E188Q|GJC1_uc002ihl.3_Missense_Mutation_p.E188Q|GJC1_uc021tyf.1_Missense_Mutation_p.E188Q	NM_005497	NP_005488	P36383	CXG1_HUMAN	Homo sapiens gap junction protein, gamma 1, 45kDa (GJC1), transcript variant 1, mRNA.	188					cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane				NS(1)|kidney(1)|large_intestine(5)|liver(1)|lung(10)|prostate(1)	19		Prostate(33;0.0959)				AAACCCACCTCAAACACGGTC	0.493000														185			109		0	0	0.000781405	0	0
SPINT2	10653	broad.mit.edu	37	19	38774304	38774304	+	Silent	SNP	G	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr19:38774304G>T	uc002ohr.2	+	1	579	c.144G>T	c.(142-144)cgG>cgT	p.R48R	SPINT2_uc002ohs.2_Intron	NM_021102	NP_066925	O43291	SPIT2_HUMAN	Homo sapiens serine peptidase inhibitor, Kunitz type, 2 (SPINT2), transcript variant a, mRNA.	48	BPTI/Kunitz inhibitor 1.	Reactive bond (By similarity).			cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(1)|ovary(1)	4	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCAGATGCCGGGCCTCCATGC	0.562000														110			46		4.49093e-37	1.90077e-35	0.000781405	1	0
P2RY1	5028	broad.mit.edu	37	3	152553966	152553966	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr3:152553966A>G	uc003ezq.3	+	0	1231	c.395A>G	c.(394-396)cAt>cGt	p.H132R		NM_002563	NP_002554	P47900	P2RY1_HUMAN	Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 (P2RY1), mRNA.	132					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TTCATCTTTCATGTGAACCTC	0.507000														56			29		0	0	0.000279167	0	0
RHBG	57127	broad.mit.edu	37	1	156347130	156347130	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr1:156347130G>C	uc010pho.2	+	1	264	c.226G>C	c.(226-228)Ggc>Cgc	p.G76R	RHBG_uc010phm.1_Intron|RHBG_uc010phn.1_Non-coding_Transcript|RHBG_uc001fos.3_Missense_Mutation_p.G7R|RHBG_uc009wrz.3_Missense_Mutation_p.G7R|RHBG_uc001for.3_Missense_Mutation_p.G46R	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Homo sapiens Rh family, B glycoprotein (gene/pseudogene) (RHBG), transcript variant 1, mRNA.	76			G -> D (in dbSNP:rs2245623).		transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					CGTGGGCTTTGGCTTCCTCAT	0.637000														81			37		0	0	0.000270559	0	0
COL22A1	169044	broad.mit.edu	37	8	139737673	139737673	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr8:139737673C>T	uc003yvd.3	-	23	2597	c.2150G>A	c.(2149-2151)gGa>gAa	p.G717E	COL22A1_uc011ljo.2_Missense_Mutation_p.G17E	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	Homo sapiens collagen, type XXII, alpha 1 (COL22A1), mRNA.	717	Collagen-like 5.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ACCAGGGGGTCCTGGAGGGCC	0.582000										HNSCC(7;0.00092)				72			38		0	0	0.000270559	0	0
UGT1A1	54658	broad.mit.edu	37	2	234622277	234622277	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:234622277A>G	uc002vuw.3	+	0	640	c.640A>G	c.(640-642)Atg>Gtg	p.M214V	UGT1A1_uc010zmv.1_Intron|UGT1A1_uc002vup.3_Intron|UGT1A1_uc002vuq.3_Intron|UGT1A1_uc002vur.3_Intron|UGT1A1_uc010zmw.1_Intron|UGT1A1_uc002vus.3_Intron|UGT1A1_uc010zmx.1_Intron|UGT1A1_uc002vut.3_Intron|UGT1A1_uc002vuu.3_Intron|UGT1A1_uc010zmy.1_Intron|UGT1A1_uc002vuv.4_Intron|UGT1A1_uc010zmz.1_Missense_Mutation_p.M214V	NM_019078	NP_061951	P22309	UD11_HUMAN	Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A5 (UGT1A5), mRNA.	213					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	GGTCAAGAACATGCTCTACCC	0.483000														149			175		0	0	0.000781405	0	0
WDR66	144406	broad.mit.edu	37	12	122398516	122398516	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr12:122398516A>G	uc009zxk.3	+	13	2318	c.2159A>G	c.(2158-2160)tAc>tGc	p.Y720C	WDR66_uc021rfh.1_Missense_Mutation_p.Y720C	NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	Homo sapiens WD repeat domain 66 (WDR66), transcript variant 1, mRNA.	720							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GTGGCTGTTTACATGCTGGTG	0.433000														158			3		0	0	6.4e-05	0	0
LAP3	51056	broad.mit.edu	37	4	17586653	17586653	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr4:17586653C>A	uc003gph.1	+	5	760	c.598C>A	c.(598-600)Cgc>Agc	p.R200S	LAP3_uc010ieg.3_3'UTR	NM_015907	NP_056991	P28838	AMPL_HUMAN	Homo sapiens leucine aminopeptidase 3 (LAP3), mRNA.	200					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|urinary_tract(1)	20						GAACTTGGCACGCCAATTGAT	0.473000														60			16		5.35267e-07	2.10173e-05	0.000958276	1	0
ABCA13	154664	broad.mit.edu	37	7	48506568	48506568	+	Silent	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr7:48506568C>T	uc003toq.2	+	43	12855	c.12831C>T	c.(12829-12831)aaC>aaT	p.N4277N	ABCA13_uc010kys.1_Silent_p.N1352N|ABCA13_uc010kyt.1_Non-coding_Transcript|ABCA13_uc010kyu.1_Intron	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	Homo sapiens ATP-binding cassette, sub-family A (ABC1), member 13 (ABCA13), mRNA.	4277			N -> D (in dbSNP:rs4917152).		transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GGGGCGACAACTTGGACCTCA	0.498000														125			71		0	0	0.000781405	0	0
GON4L	54856	broad.mit.edu	37	1	155630357	155630357	+	Silent	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr1:155630357G>A	uc010pgi.2	-	9	1950	c.1758C>T	c.(1756-1758)ctC>ctT	p.L586L	GON4L_uc021paz.1_Silent_p.L428L|GON4L_uc010pgg.2_Silent_p.L333L|GON4L_uc010pgh.2_Silent_p.L437L|GON4L_uc009wqt.3_Silent_p.L417L|GON4L_uc001flh.3_Silent_p.L566L|GON4L_uc001fll.3_Silent_p.L448L|GON4L_uc001flk.3_Silent_p.L437L|GON4L_uc001flm.3_Silent_p.L437L|GON4L_uc009wqu.3_Silent_p.L281L|GON4L_uc009wqv.3_Silent_p.L165L|GON4L_uc009wqw.3_Silent_p.L417L|GON4L_uc001flj.3_Silent_p.L428L|GON4L_uc001fli.3_Silent_p.L448L|GON4L_uc001flo.3_Silent_p.L382L|GON4L_uc001fln.3_Silent_p.L494L|GON4L_uc010pgj.2_3'UTR|GON4L_uc001flp.3_Silent_p.L448L	NM_001198903	NP_001185832	Q3T8J9	GON4L_HUMAN	Homo sapiens YY1 associated protein 1 (YY1AP1), transcript variant 10, mRNA.	1037					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAGGAATCCGGAGCACCATTT	0.552000														76			37		0	0	0.000953801	0	0
ZFHX3	463	broad.mit.edu	37	16	72992638	72992638	+	Silent	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr16:72992638C>T	uc002fck.3	-	1	2080	c.1407G>A	c.(1405-1407)gaG>gaA	p.E469E	ZFHX3_uc002fcl.3_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	469	Poly-Glu.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ccgcctcttcctcctcctctt	0.587000														25			7		0	0	0.000274275	0	0
DPYD	1806	broad.mit.edu	37	1	98058809	98058809	+	Nonsense_Mutation	SNP	T	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr1:98058809T>A	uc001drv.3	-	9	1230	c.1093A>T	c.(1093-1095)Aaa>Taa	p.K365*		NM_000110	NP_000101	Q12882	DPYD_HUMAN	Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA.	365					'de novo' pyrimidine base biosynthetic process|UMP biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|NADP binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ACAAAGCCTTTTCTGAAGACG	0.448000														71			45		0	0	0.000680045	0	0
SH3TC1	54436	broad.mit.edu	37	4	8230107	8230107	+	Silent	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr4:8230107C>T	uc003gkv.4	+	11	2787	c.2686C>T	c.(2686-2688)Ctg>Ttg	p.L896L	SH3TC1_uc003gkw.4_Silent_p.L820L|SH3TC1_uc003gkx.4_Non-coding_Transcript|SH3TC1_uc003gky.3_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	Homo sapiens SH3 domain and tetratricopeptide repeats 1 (SH3TC1), mRNA.	896							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						GGCTCGGGACCTGGGCCAGCA	0.692000														46			51		0	0	0.000781405	0	0
MPRIP	23164	broad.mit.edu	37	17	17030034	17030034	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:17030034G>A	uc002gqv.2	+	3	375	c.286G>A	c.(286-288)Ggc>Agc	p.G96S	MPRIP_uc002gqu.2_Missense_Mutation_p.G96S	NM_015134	NP_055949	Q6WCQ1	MPRIP_HUMAN	Homo sapiens myosin phosphatase Rho interacting protein (MPRIP), transcript variant 1, mRNA.	96	Interaction with F-actin (By similarity).|PH 1.					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						CCTTCCTCAGGGCACCATCAA	0.602000														72			30		0	0	0.000279167	0	0
SLC13A1	6561	broad.mit.edu	37	7	122765636	122765636	+	Silent	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr7:122765636A>G	uc003vkm.3	-	10	1252	c.1227T>C	c.(1225-1227)ccT>ccC	p.P409P	SLC13A1_uc010lks.3_Silent_p.P285P	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	Homo sapiens solute carrier family 13 (sodium/sulfate symporters), member 1 (SLC13A1), mRNA.	409						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TTTCTCCTGTAGGTGTAGTTT	0.368000														192			127		0	0	0.000781405	0	0
SYNPR	132204	broad.mit.edu	37	3	63466530	63466530	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr3:63466530C>T	uc003dlp.3	+	2	403	c.107C>T	c.(106-108)gCa>gTa	p.A36V	SYNPR_uc011bfk.2_Intron|SYNPR_uc011bfl.2_Non-coding_Transcript|SYNPR_uc003dlq.3_Missense_Mutation_p.A16V|SYNPR_uc010hnt.3_Missense_Mutation_p.A25V|SYNPR_uc011bfm.2_Non-coding_Transcript	NM_001130003	NP_001123475	Q8TBG9	SYNPR_HUMAN	Homo sapiens synaptoporin (SYNPR), transcript variant 1, mRNA.	16	MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		TTTGCATTTGCAACATGCGGT	0.433000														121			78		0	0	0.000781405	0	0
SPG11	80208	broad.mit.edu	37	15	44951365	44951365	+	Silent	SNP	A	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr15:44951365A>T	uc001ztx.3	-	2	610	c.579T>A	c.(577-579)ctT>ctA	p.L193L	SPG11_uc010ueh.2_Silent_p.L193L|SPG11_uc010uei.2_Silent_p.L193L|SPG11_uc001zua.1_Silent_p.L193L	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	Homo sapiens spastic paraplegia 11 (autosomal recessive) (SPG11), transcript variant 1, mRNA.	193					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CAGGCAAGGGAAGTGTGAAAC	0.398000														88			48		0	0	0.000781405	0	0
SSBP4	170463	broad.mit.edu	37	19	18538728	18538728	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr19:18538728G>A	uc002niy.3	+	3	528	c.215G>A	c.(214-216)tGc>tAc	p.C72Y	SSBP4_uc010ebp.3_Missense_Mutation_p.C72Y|SSBP4_uc002niz.3_Missense_Mutation_p.C72Y	NM_032627	NP_116016	Q9BWG4	SSBP4_HUMAN	Homo sapiens single stranded DNA binding protein 4 (SSBP4), transcript variant 1, mRNA.	72						nucleus	single-stranded DNA binding			endometrium(2)|kidney(1)|skin(1)	4						GACCTGTACTGCGCGGCGCCT	0.667000														51			33		0	0	0.000953801	0	0
BC101079	0	broad.mit.edu	37	15	102292785	102292785	+	Missense_Mutation	SNP	C	G	G	rs61084368		TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr15:102292785C>G	uc010usj.2	+	3	432	c.373C>G	c.(373-375)Cag>Gag	p.Q125E	DQ593624_uc002bxp.4_5'Flank|DQ576888_uc021sxy.1_5'Flank|DQ596486_uc002bxz.4_5'Flank|DQ582294_uc021syc.1_5'Flank|DQ595661_uc021sye.1_5'Flank|DQ588439_uc002byd.3_5'Flank|DQ593353_uc002bye.3_5'Flank|DQ597703_uc002byf.1_5'Flank|DQ585237_uc002byg.3_5'Flank|DQ588452_uc021syg.1_5'Flank|DQ586526_uc002byi.3_5'Flank|DQ588428_uc002byk.3_5'Flank|DQ597703_uc002bym.3_5'Flank|DQ571896_uc010usm.2_5'Flank|DQ586526_uc021syh.1_5'Flank|DQ588425_uc002byr.3_5'Flank					Homo sapiens cDNA clone IMAGE:40009338.									p.Q125E(1)									TGCTGCTTCTCAGAGCTGCTG	0.602000														16			5		0	0	8.12818e-05	0	0
CACNA1G	8913	broad.mit.edu	37	17	48669448	48669448	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:48669448G>A	uc002irk.1	+	12	3277	c.2905G>A	c.(2905-2907)Gcg>Acg	p.A969T	CACNA1G_uc002iri.1_Missense_Mutation_p.A969T|CACNA1G_uc002irj.1_Missense_Mutation_p.A969T|CACNA1G_uc002irl.1_Missense_Mutation_p.A969T|CACNA1G_uc002irm.1_Missense_Mutation_p.A969T|CACNA1G_uc002irn.1_Missense_Mutation_p.A969T|CACNA1G_uc002iro.1_Missense_Mutation_p.A969T|CACNA1G_uc002irp.1_Missense_Mutation_p.A969T|CACNA1G_uc002irq.1_Missense_Mutation_p.A969T|CACNA1G_uc002irr.1_Missense_Mutation_p.A969T|CACNA1G_uc002irs.1_Missense_Mutation_p.A969T|CACNA1G_uc002irt.1_Missense_Mutation_p.A969T|CACNA1G_uc002iru.1_Missense_Mutation_p.A969T|CACNA1G_uc002irv.1_Missense_Mutation_p.A969T|CACNA1G_uc002irw.1_Missense_Mutation_p.A969T|CACNA1G_uc002irx.1_Missense_Mutation_p.A882T|CACNA1G_uc002iry.1_Missense_Mutation_p.A882T|CACNA1G_uc002isg.1_Missense_Mutation_p.A882T|CACNA1G_uc002ish.1_Missense_Mutation_p.A882T|CACNA1G_uc002isi.1_Missense_Mutation_p.A882T|CACNA1G_uc002irz.1_Missense_Mutation_p.A882T|CACNA1G_uc002isa.1_Missense_Mutation_p.A882T|CACNA1G_uc002isd.1_Missense_Mutation_p.A882T|CACNA1G_uc002isb.1_Missense_Mutation_p.A882T|CACNA1G_uc002isc.1_Missense_Mutation_p.A882T|CACNA1G_uc002ise.1_Missense_Mutation_p.A882T|CACNA1G_uc002isf.1_Missense_Mutation_p.A882T	NM_018896	NP_061496	O43497	CAC1G_HUMAN	Homo sapiens calcium channel, voltage-dependent, T type, alpha 1G subunit (CACNA1G), transcript variant 1, mRNA.	969					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGCTTCCAGGCGGAGGTAAC	0.582000														42			30		0	0	0.000491102	0	0
SAMD14	201191	broad.mit.edu	37	17	48190273	48190273	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:48190273T>G	uc002iqf.3	-	10	1621	c.1322A>C	c.(1321-1323)gAg>gCg	p.E441A	SAMD14_uc002iqe.3_Missense_Mutation_p.E196A|SAMD14_uc002iqg.3_Missense_Mutation_p.E413A	NM_174920	NP_777580	Q8IZD0	SAM14_HUMAN	Homo sapiens sterile alpha motif domain containing 14 (SAMD14), mRNA.	413										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						CTTCTTGGCCTCCTGCTCTCG	0.697000														64			38		0	0	0.000374591	0	0
IGSF9B	22997	broad.mit.edu	37	11	133794760	133794760	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr11:133794760C>T	uc001qgx.4	-	14	2305	c.2074G>A	c.(2074-2076)Gat>Aat	p.D692N	IGSF9B_uc001qgy.1_Missense_Mutation_p.D534N	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	Homo sapiens immunoglobulin superfamily, member 9B (IGSF9B), mRNA.	692	Fibronectin type-III 2.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTGATCAGATCCTGCATGACG	0.587000														91			43		0	0	0.000781405	0	0
NDFIP1	80762	broad.mit.edu	37	5	141524144	141524144	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr5:141524144C>G	uc003lmi.4	+	6	787	c.571C>G	c.(571-573)Ctg>Gtg	p.L191V	NDFIP1_uc003lmj.1_Intron	NM_030571	NP_085048	Q9BT67	NFIP1_HUMAN	Homo sapiens Nedd4 family interacting protein 1 (NDFIP1), mRNA.	191					cellular iron ion homeostasis|negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	Golgi membrane|endosome membrane|extracellular region|integral to membrane|perinuclear region of cytoplasm	signal transducer activity			large_intestine(3)|lung(1)|ovary(1)	5		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCTTTCTCCTGTTTCTCAG	0.358000														121			39		0	0	0.000437636	0	0
AGBL5	60509	broad.mit.edu	37	2	27291539	27291539	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:27291539A>G	uc002rie.3	+	12	2499	c.2282A>G	c.(2281-2283)gAg>gGg	p.E761G	AGBL5_uc002rif.3_Non-coding_Transcript	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	Homo sapiens ATP/GTP binding protein-like 5 (AGBL5), transcript variant 1, mRNA.	761					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACAAACCAGAGGCTGTCATG	0.512000														93			42		0	0	0.000589545	0	0
MIR668	768214	broad.mit.edu	37	14	101521660	101521660	+	Splice_Site	SNP	C	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr14:101521660C>G	uc021sdl.1	+	1		c.66_splice	c.e1+1		MIR485_uc021sdm.1_5'Flank|MIR323B_uc021sdn.1_5'Flank					Homo sapiens microRNA 668 (MIR668), microRNA.																		GGCCCACTACCCAATACTATC	0.562000														49			20		0	0	0.000175454	0	0
SEC16A	9919	broad.mit.edu	37	9	139371469	139371469	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr9:139371469G>A	uc004chx.3	-	2	908	c.599C>T	c.(598-600)gCa>gTa	p.A200V	SEC16A_uc004chv.4_5'Flank|SEC16A_uc004chw.3_Missense_Mutation_p.A200V|SEC16A_uc010nbn.3_Missense_Mutation_p.A200V|SEC16A_uc010nbo.1_Missense_Mutation_p.A200V	NM_014866	NP_055681	O15027	SC16A_HUMAN	Homo sapiens SEC16 homolog A (S. cerevisiae) (SEC16A), mRNA.	22					protein transport|vesicle-mediated transport	Golgi membrane|endoplasmic reticulum membrane		p.A199V(1)		breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GGAAGGGGATGCTGCTGGGGT	0.652000														30			27		0	0	0.000147802	0	0
CYP2S1	29785	broad.mit.edu	37	19	41712375	41712375	+	Silent	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr19:41712375C>T	uc002opw.3	+	8	1552	c.1497C>T	c.(1495-1497)tcC>tcT	p.S499S	CYP2S1_uc010xvx.2_Silent_p.S224S	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily S, polypeptide 1 (CYP2S1), mRNA.	499					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						ACCTTCACTCCACCACGCAGA	0.607000														76			8		0	0	0.000157383	0	0
TROAP	10024	broad.mit.edu	37	12	49717751	49717751	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr12:49717751A>C	uc009zlh.3	+	2	435	c.268A>C	c.(268-270)Aac>Cac	p.N90H	TROAP_uc001rtv.3_Missense_Mutation_p.N90H|TROAP_uc001rtw.4_Missense_Mutation_p.N90H|TROAP_uc001rtx.4_Missense_Mutation_p.N90H	NM_005480	NP_005471	Q12815	TROAP_HUMAN	Homo sapiens trophinin associated protein (tastin) (TROAP), transcript variant 1, mRNA.	90					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						TCAGCCTCGGAACCCCTTGGA	0.602000														86			28		0	0	0.000147802	0	0
MYH10	4628	broad.mit.edu	37	17	8416922	8416922	+	Silent	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:8416922C>T	uc002glm.3	-	22	2775	c.2679G>A	c.(2677-2679)ttG>ttA	p.L893L	MYH10_uc002gll.3_Silent_p.L862L|MYH10_uc010cnx.3_Silent_p.L871L	NM_005964	NP_005955	P35580	MYH10_HUMAN	Homo sapiens myosin, heavy chain 10, non-muscle (MYH10), transcript variant 2, mRNA.	862					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	ADP binding|ATP binding|actin filament binding|actin-dependent ATPase activity|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						CCTTCACCTTCAACAGCTCTT	0.483000														307			11		0	0	0.00010058	0	0
SLC25A42	284439	broad.mit.edu	37	19	19218750	19218750	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr19:19218750G>T	uc002nlf.2	+	6	701	c.545G>T	c.(544-546)gGg>gTg	p.G182V		NM_178526	NP_848621	Q86VD7	S2542_HUMAN	Homo sapiens solute carrier family 25, member 42 (SLC25A42), mRNA.	182					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			cervix(1)|large_intestine(2)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			AGAGAAGAGGGGCTGAAGACT	0.572000														74			46		2.47872e-24	1.03566e-22	0.000509022	1	0
PLOD2	5352	broad.mit.edu	37	3	145806381	145806381	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr3:145806381G>A	uc003evr.1	-	8	1503	c.997C>T	c.(997-999)Cat>Tat	p.H333Y	PLOD2_uc003evq.1_5'Flank|PLOD2_uc011bnm.1_Missense_Mutation_p.H278Y|PLOD2_uc003evs.1_Missense_Mutation_p.H333Y	NM_182943	NP_891988	O00469	PLOD2_HUMAN	Homo sapiens procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), transcript variant 1, mRNA.	333					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	L-ascorbic acid binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	ACTTTGTTATGAATAAAAAGT	0.294000														20			8		0	0	0.000157383	0	0
APOB	338	broad.mit.edu	37	2	21260848	21260848	+	Silent	SNP	G	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:21260848G>A	uc002red.3	-	4	647	c.519C>T	c.(517-519)gcC>gcT	p.A173A		NM_000384	NP_000375	P04114	APOB_HUMAN	Homo sapiens apolipoprotein B (including Ag(x) antigen) (APOB), mRNA.	173	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.A173D(1)		NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACACTTGCTTGGCTTCTTCTG	0.458000														58			79		0	0	0.000781405	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790126	133790126	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr11:133790126C>A	uc001qgx.4	-	17	3725	c.3494G>T	c.(3493-3495)gGc>gTc	p.G1165V		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	Homo sapiens immunoglobulin superfamily, member 9B (IGSF9B), mRNA.	1165	Pro-rich.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GGTGTCCAGGCCAAATGTGCT	0.692000														51			31		1.26612e-14	5.09417e-13	0.00058488	1	0
ADD3	120	broad.mit.edu	37	10	111860443	111860443	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr10:111860443C>G	uc001kyu.3	+	1	188	c.32C>G	c.(31-33)aCc>aGc	p.T11S	ADD3_uc001kyt.4_Missense_Mutation_p.T11S|ADD3_uc001kys.4_Missense_Mutation_p.T11S|ADD3_uc001kyv.3_Missense_Mutation_p.T11S|ADD3_uc001kyw.3_Missense_Mutation_p.T11S	NM_016824	NP_058432	Q9UEY8	ADDG_HUMAN	Homo sapiens adducin 3 (gamma) (ADD3), transcript variant 1, mRNA.	11						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		GGCGTGATTACCACTCCTCCT	0.418000														36			21		0	0	0.000720815	0	0
ADAM17	6868	broad.mit.edu	37	2	9645412	9645412	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:9645412T>G	uc002qzu.3	-	11	1610	c.1427A>C	c.(1426-1428)aAa>aCa	p.K476T	ADAM17_uc010ewy.3_Missense_Mutation_p.K476T|ADAM17_uc010ewz.3_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), mRNA.	476	Disintegrin.				B cell differentiation|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|T cell differentiation in thymus|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|positive regulation of T cell chemotaxis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	PDZ domain binding|SH3 domain binding|integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CCCACAAACTTTATTGCTGCG	0.438000														72			63		0	0	0.000781405	0	0
DDX60L	91351	broad.mit.edu	37	4	169317122	169317122	+	Silent	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr4:169317122C>T	uc021xuh.1	-	25	3755	c.3645G>A	c.(3643-3645)agG>agA	p.R1215R	DDX60L_uc003irq.4_Silent_p.R1215R|DDX60L_uc003irr.1_Silent_p.R1216R|DDX60L_uc003irs.1_Silent_p.R910R	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like (DDX60L), mRNA.	1215	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		AGTCTTTATTCCTGGTAATTT	0.343000														52			49		0	0	0.000781405	0	0
KRT17	3872	broad.mit.edu	37	17	39777877	39777877	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:39777877G>T	uc002hxh.2	-	3	923	c.802C>A	c.(802-804)Cgc>Agc	p.R268S	JUP_uc010wfs.2_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	Homo sapiens keratin 17 (KRT17), mRNA.	268	Coil 2.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	12		Breast(137;0.000307)				GCATCCTTGCGGTTCTTCTCT	0.592000														158			6		5.18039e-06	0.000198622	0.000157383	1	0
VEZF1	7716	broad.mit.edu	37	17	56060465	56060465	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr17:56060465G>T	uc002ivf.1	-	1	466	c.323C>A	c.(322-324)aCc>aAc	p.T108N	VEZF1_uc010dcn.1_5'UTR	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	Homo sapiens vascular endothelial zinc finger 1 (VEZF1), mRNA.	108					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)	10						CGTGGTGGGGGTTTTCTTTGG	0.547000														70			55		2.74224e-37	1.17592e-35	0.000781405	1	0
ZNF680	340252	broad.mit.edu	37	7	63982808	63982808	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr7:63982808T>C	uc003tta.2	-	3	497	c.324A>G	c.(322-324)atA>atG	p.I108M		NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	Homo sapiens zinc finger protein 680 (ZNF680), transcript variant 1, mRNA.	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				ATCCTCTCAGTATCACTTTTT	0.318000														124			5		0	0	0.000602214	0	0
WDR70	55100	broad.mit.edu	37	5	37381726	37381726	+	Silent	SNP	C	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr5:37381726C>T	uc003jkv.3	+	2	172	c.114C>T	c.(112-114)gaC>gaT	p.D38D	WDR70_uc010iva.1_Silent_p.D38D	NM_018034	NP_060504	Q9NW82	WDR70_HUMAN	Homo sapiens WD repeat domain 70 (WDR70), mRNA.	38										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCACATTTGACTTGGAAGCAA	0.378000														120			59		0	0	0.000781405	0	0
MRVI1	10335	broad.mit.edu	37	11	10647666	10647666	+	Silent	SNP	C	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr11:10647666C>G	uc010rcc.1	-	8	1601	c.1215G>C	c.(1213-1215)cgG>cgC	p.R405R	MRVI1_uc010rcb.1_Silent_p.R397R|MRVI1_uc001miw.2_Silent_p.R396R|MRVI1_uc001mix.3_Silent_p.R90R|MRVI1_uc001miz.2_Silent_p.R314R|MRVI1_uc010rcd.1_Intron|MRVI1_uc009ygd.1_Silent_p.R90R|MRVI1_uc010rce.1_Intron	NM_130385	NP_569056	Q9Y6F6	MRVI1_HUMAN	Homo sapiens murine retrovirus integration site 1 homolog (MRVI1), transcript variant 2, mRNA.	378					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTTTCTGCAGCCGGGGGCCAG	0.647000														16			9		0	0	0.000673444	0	0
MX1	4599	broad.mit.edu	37	21	42807881	42807881	+	Missense_Mutation	SNP	G	A	A	rs150271063		TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr21:42807881G>A	uc010goq.3	+	3	569	c.223G>A	c.(223-225)Gtc>Atc	p.V75I	MX1_uc002yzh.3_Missense_Mutation_p.V75I|MX1_uc002yzi.3_Missense_Mutation_p.V75I	NM_001178046	NP_002453	P20591	MX1_HUMAN	Homo sapiens myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (MX1), transcript variant 3, mRNA.	75					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding	p.A74A(1)		breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	27		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				AGCCATCGCCGTCATCGGGGA	0.607000														53			29		0	0	0.000339439	0	0
NDFIP1	80762	broad.mit.edu	37	5	141524143	141524143	+	Silent	SNP	C	A	A			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr5:141524143C>A	uc003lmi.4	+	6	786	c.570C>A	c.(568-570)ctC>ctA	p.L190L	NDFIP1_uc003lmj.1_Intron	NM_030571	NP_085048	Q9BT67	NFIP1_HUMAN	Homo sapiens Nedd4 family interacting protein 1 (NDFIP1), mRNA.	190					cellular iron ion homeostasis|negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	Golgi membrane|endosome membrane|extracellular region|integral to membrane|perinuclear region of cytoplasm	signal transducer activity			large_intestine(3)|lung(1)|ovary(1)	5		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGGCTTTCTCCTGTTTCTCA	0.358000														119			41		3.76604e-16	1.53419e-14	0.000509022	1	0
MYCN	4613	broad.mit.edu	37	2	16082320	16082321	+	Frame_Shift_Ins	INS	-	G	G			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:16082320_16082321insG	uc002rci.3	+	1	434_435	c.134_135insG	c.(133-135)ccgfs	p.P45fs	MYCNOS_uc002rch.1_5'Flank|MYCN_uc010yjr.2_Frame_Shift_Ins_p.P45fs	NM_005378	NP_005369	P04198	MYCN_HUMAN	Homo sapiens v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN), mRNA.	45					regulation of transcription from RNA polymerase II promoter	chromatin|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.P44L(7)		NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	31	all_cancers(1;1.35e-08)|all_neural(1;2.92e-24)|Lung SC(1;3.26e-07)|Medulloblastoma(1;6.9e-06)|all_lung(1;1.26e-05)|Glioma(3;0.135)|Acute lymphoblastic leukemia(172;0.155)|all_epithelial(1;0.169)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(3;0.000332)			TCGACCCCCCCGGGGGAGGACA	0.644			A		neuroblastoma								---	29	---	---	23	---					
ITSN2	50618	broad.mit.edu	37	2	24509153	24509155	+	In_Frame_Del	DEL	TTC	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:24509153_24509155delTTC	uc002rfe.2	-	15	2047_2049	c.1789_1791delGAA	c.(1789-1791)gaadel	p.E597del	ITSN2_uc002rff.2_In_Frame_Del_p.E597del|ITSN2_uc002rfg.3_In_Frame_Del_p.E597del|ITSN2_uc010eyd.2_In_Frame_Del_p.E622del	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	Homo sapiens intersectin 2 (ITSN2), transcript variant 1, mRNA.	597					endocytosis|regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity|calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATCTAACTGTTCTTTAAGTCTT	0.286													---	97	---	---	24	---					
UBR3	130507	broad.mit.edu	37	2	170843280	170843281	+	Frame_Shift_Ins	INS	-	T	T			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:170843280_170843281insT	uc010zdi.2	+	24	3760_3761	c.3760_3761insT	c.(3760-3762)gttfs	p.V1254fs	UBR3_uc002ufr.4_Non-coding_Transcript|UBR3_uc010fqa.3_Frame_Shift_Ins_p.V75fs|UBR3_uc002uft.4_Frame_Shift_Ins_p.V107fs	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 3 (putative) (UBR3), mRNA.	1254					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						TACTGGATTAGTTGTACTGTTA	0.396													---	105	---	---	32	---					
NDUFS1	4719	broad.mit.edu	37	2	207006722	207006724	+	In_Frame_Del	DEL	AGA	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:207006722_207006724delAGA	uc010ziq.2	-	11	1306_1308	c.1245_1247delTCT	c.(1243-1248)cttctg>ctg	p.415_416LL>L	NDUFS1_uc002vbe.3_In_Frame_Del_p.401_402LL>L|NDUFS1_uc010zir.2_In_Frame_Del_p.365_366LL>L|NDUFS1_uc010zis.2_In_Frame_Del_p.344_345LL>L|NDUFS1_uc010zit.2_In_Frame_Del_p.290_291LL>L|NDUFS1_uc010ziu.2_In_Frame_Del_p.285_286LL>L	NM_001199984	NP_001186913	P28331	NDUS1_HUMAN	Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (NDUFS1), transcript variant 5, mRNA.	401					ATP metabolic process|apoptosis|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|NADH dehydrogenase (ubiquinone) activity|electron carrier activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(15)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					NADH(DB00157)	TGTACCAACCAGAAGAACAACAT	0.325													---	117	---	---	21	---					
LRRFIP1	9208	broad.mit.edu	37	2	238672176	238672176	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr2:238672176delA	uc002vxe.3	+	10	2112	c.1820delA	c.(1819-1821)gaafs	p.E607fs	LRRFIP1_uc002vxc.3_Intron|LRRFIP1_uc010znm.2_Intron|LRRFIP1_uc002vxd.3_Frame_Shift_Del_p.E583fs|LRRFIP1_uc002vxf.3_Frame_Shift_Del_p.E551fs	NM_001137552	NP_001131024	Q32MZ4	LRRF1_HUMAN	Homo sapiens leucine rich repeat (in FLII) interacting protein 1 (LRRFIP1), transcript variant 3, mRNA.	607					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		GAAATTAAGGAAGAAGAGCAG	0.373													---	36	---	---	8	---					
TOPBP1	11073	broad.mit.edu	37	3	133329894	133329895	+	Frame_Shift_Ins	INS	-	CT	CT			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr3:133329894_133329895insCT	uc003eps.3	-	24	4258_4259	c.4126_4127insAG	c.(4126-4128)agafs	p.R1376fs		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	Homo sapiens topoisomerase (DNA) II binding protein 1 (TOPBP1), mRNA.	1376					DNA repair|response to ionizing radiation	PML body|microtubule organizing center|spindle pole	DNA binding|protein C-terminus binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	40						TTTTCTCCATCTCATTGCTGCA	0.356								Other conserved DNA damage response genes					---	156	---	---	88	---					
MGAM	8972	broad.mit.edu	37	7	141794622	141794622	+	Frame_Shift_Del	DEL	T	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr7:141794622delT	uc003vwy.3	+	39	4783	c.4729delT	c.(4729-4731)tttfs	p.F1577fs		NM_004668	NP_004659	O43451	MGA_HUMAN	Homo sapiens maltase-glucoamylase (alpha-glucosidase) (MGAM), mRNA.	1577	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GCTGGGGGCCTTTTACCCCTT	0.493													---	130	---	---	7	---					
TPD52	7163	broad.mit.edu	37	8	80963849	80963851	+	In_Frame_Del	DEL	GAT	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr8:80963849_80963851delGAT	uc022awn.1	-	3	739_741	c.417_419delATC	c.(415-420)acatct>act	p.S140del	TPD52_uc010lzr.3_Non-coding_Transcript|TPD52_uc010lzs.1_Non-coding_Transcript|TPD52_uc003ybs.1_In_Frame_Del_p.S100del|TPD52_uc003ybt.1_In_Frame_Del_p.S100del|TPD52_uc003ybq.1_Non-coding_Transcript|TPD52_uc003ybr.1_In_Frame_Del_p.S140del|TPD52_uc022awm.1_Non-coding_Transcript|TPD52_uc022awo.1_In_Frame_Del_p.S140del|TPD52_uc022awp.1_In_Frame_Del_p.S140del	NM_001025253	NP_001020424	P55327	TPD52_HUMAN	Homo sapiens tumor protein D52 (TPD52), transcript variant 2, mRNA.	140					B cell differentiation|anatomical structure morphogenesis|secretion	endoplasmic reticulum|perinuclear region of cytoplasm	calcium ion binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	8	all_epithelial(4;1.13e-09)|Lung NSC(7;9.71e-07)|all_lung(9;3.75e-06)	Lung NSC(129;3.55e-06)|all_lung(136;1.53e-05)|Acute lymphoblastic leukemia(644;0.158)	BRCA - Breast invasive adenocarcinoma(6;0.00181)|Epithelial(68;0.0149)|all cancers(69;0.0612)			TAAGGTTTCAGATGTCTTCTTGT	0.404													---	49	---	---	26	---					
ZNF658	26149	broad.mit.edu	37	9	40772391	40772392	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr9:40772391_40772392delCT	uc004abs.2	-	4	3035_3036	c.2883_2884delAG	c.(2881-2886)acagggfs	p.T961fs	ZNF658_uc010mmm.2_Intron|ZNF658_uc010mmn.1_Frame_Shift_Del_p.T961fs	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	Homo sapiens zinc finger protein 658 (ZNF658), mRNA.	961					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GATTTCTCCCCTGTGTGAATTC	0.436													---	153	---	---	8	---					
C9orf86	55684	broad.mit.edu	37	9	139734633	139734635	+	In_Frame_Del	DEL	AGA	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr9:139734633_139734635delAGA	uc004cjj.1	+	13	2418_2420	c.1961_1963delAGA	c.(1960-1965)gagaag>gag	p.K661del	C9orf86_uc004cji.1_In_Frame_Del_p.K660del|C9orf86_uc004cjk.1_Non-coding_Transcript|C9orf86_uc004cjl.1_Non-coding_Transcript|C9orf86_uc010nbs.1_In_Frame_Del_p.K545del|C9orf86_uc004cjn.1_In_Frame_Del_p.K454del	NM_001173988	NP_001167459	Q3YEC7	PARF_HUMAN	Homo sapiens chromosome 9 open reading frame 86 (C9orf86), transcript variant 3, mRNA.	660	Interaction with CDKN2A.|Lys-rich.				small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding			endometrium(4)|kidney(1)|lung(4)	9	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		CCCTCTaaggagaagaagaagaa	0.571													---	60	---	---	7	---					
ATP2A1	487	broad.mit.edu	37	16	28913640	28913640	+	Frame_Shift_Del	DEL	C	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr16:28913640delC	uc002dro.1	+	16	2641	c.2457delC	c.(2455-2457)cgcfs	p.R819fs	NPIPL1_uc010vct.2_Intron|ATP2A1_uc002drn.1_Frame_Shift_Del_p.R819fs|ATP2A1_uc002drp.1_Frame_Shift_Del_p.R694fs	NM_173201	NP_775293	O14983	AT2A1_HUMAN	Homo sapiens ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 (ATP2A1), transcript variant b, mRNA.	819					ATP biosynthetic process|apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	ER-Golgi intermediate compartment|H zone|I band|endoplasmic reticulum membrane|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						TCATGGACCGCCCCCCCCGGA	0.657													---	131	---	---	8	---					
ZFHX3	463	broad.mit.edu	37	16	72992645	72992647	+	In_Frame_Del	DEL	TCT	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chr16:72992645_72992647delTCT	uc002fck.3	-	1	2071_2073	c.1398_1400delAGA	c.(1396-1401)gaagag>gag	p.466_467EE>E	ZFHX3_uc002fcl.3_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	466	Poly-Glu.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				ttcctcctcctcttcctcctccg	0.586													---	31	---	---	7	---					
ZNF185	7739	broad.mit.edu	37	X	152087570	152087572	+	In_Frame_Del	DEL	GAG	-	-			TCGA-G7-6795-01A-11D-1961-08	TCGA-G7-6795-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1af4c17e-514e-4b9d-bfcb-ed019430178f	0428b3c1-9f63-45bc-8457-3fffb9bcf9fb	g.chrX:152087570_152087572delGAG	uc011myg.2	+	6	523_525	c.475_477delGAG	c.(475-477)gagdel	p.E165del	ZNF185_uc011myi.2_In_Frame_Del_p.E165del|ZNF185_uc011myj.2_In_Frame_Del_p.E165del|ZNF185_uc011myh.2_In_Frame_Del_p.E165del|ZNF185_uc011myk.2_In_Frame_Del_p.E165del|ZNF185_uc010ntv.2_In_Frame_Del_p.E165del|ZNF185_uc004fgw.4_In_Frame_Del_p.E30del|ZNF185_uc004fgu.3_5'UTR|ZNF185_uc004fgv.3_5'Flank	NM_001178106	NP_001171577	O15231	ZN185_HUMAN	Homo sapiens zinc finger protein 185 (LIM domain) (ZNF185), transcript variant 1, mRNA.	165	Poly-Glu.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGACACCgaggaggaggagg	0.596													---	26	---	---	7	---					
