Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPM1D	8493	broad.mit.edu	37	17	58740837	58740837	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr17:58740837G>A	uc002iyt.2	+	5	1974	c.1742G>A	c.(1741-1743)cGa>cAa	p.R581Q	PPM1D_uc010ddm.2_Non-coding_Transcript	NM_003620	NP_003611	O15297	PPM1D_HUMAN	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D), mRNA.	581					negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	15	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			CTCACCATGCGACGCAGACTT	0.443000											OREG0031485	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)		42			44		0	0	2.05139e-05	0	0
FREM2	341640	broad.mit.edu	37	13	39422803	39422803	+	Silent	SNP	C	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr13:39422803C>G	uc001uwv.3	+	7	6684	c.6375C>G	c.(6373-6375)tcC>tcG	p.S2125S	FREM2_uc001uww.3_Silent_p.S211S	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	Homo sapiens FRAS1 related extracellular matrix protein 2 (FREM2), mRNA.	2125	Calx-beta 4.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ACTCTGTCTCCGATTGTGAGT	0.358000														62			3		0	0	6.4e-05	0	0
HEBP1	50865	broad.mit.edu	37	12	13140120	13140120	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr12:13140120T>C	uc001rbd.3	-	2	559	c.364A>G	c.(364-366)Att>Gtt	p.I122V		NM_015987	NP_057071	Q9NRV9	HEBP1_HUMAN	Homo sapiens heme binding protein 1 (HEBP1), mRNA.	122					circadian rhythm	extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	7		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		CGTTCCTCAATCTTAACGCTT	0.483000														87			62		0	0	2.47226e-05	0	0
NF2	4771	broad.mit.edu	37	22	30051666	30051666	+	Splice_Site	SNP	G	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr22:30051666G>A	uc003age.4	+	6	1042	c.599_splice	c.e6+1	p.R200_splice	NF2_uc003afy.4_Splice_Site_p.R200_splice|NF2_uc003afz.4_Splice_Site_p.R117_splice|NF2_uc003agf.4_Splice_Site_p.R200_splice|NF2_uc003agb.4_Splice_Site_p.R123_splice|NF2_uc003agc.4_Splice_Site_p.R162_splice|NF2_uc003agd.4_Intron|NF2_uc003agg.4_Splice_Site_p.R200_splice|NF2_uc003aga.4_Splice_Site_p.R158_splice|NF2_uc003agh.4_Splice_Site_p.R159_splice|NF2_uc003agi.4_Splice_Site_p.R117_splice|NF2_uc003agj.4_Intron	NM_000268	NP_000259	P35240	MERL_HUMAN	Homo sapiens neurofibromin 2 (merlin) (NF2), transcript variant 1, mRNA.	200	FERM.				Schwann cell proliferation|actin cytoskeleton organization|negative regulation of DNA replication|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(5)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						GCCGAGCCAGGTGAGGCCCAT	0.408000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2					5			33		0	0	5.84002e-05	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541732	133541732	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr2:133541732C>G	uc002ttp.3	-	13	3026	c.2652G>C	c.(2650-2652)tgG>tgC	p.W884C	NCKAP5_uc002ttq.3_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Homo sapiens NCK-associated protein 5 (NCKAP5), transcript variant 1, mRNA.	884							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GGCACTGGACCCAGTCCCTCC	0.577000														27			44		0	0	2.47226e-05	0	0
ZNF30	90075	broad.mit.edu	37	19	35435141	35435141	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr19:35435141G>C	uc010edq.1	+	4	1652	c.1274G>C	c.(1273-1275)gGg>gCg	p.G425A	ZNF30_uc002nxf.2_Missense_Mutation_p.G343A|ZNF30_uc010edp.1_Missense_Mutation_p.G424A|ZNF30_uc010edr.1_Missense_Mutation_p.G425A	NM_001099437	NP_001092908	P17039	ZNF30_HUMAN	Homo sapiens zinc finger protein 30 (ZNF30), transcript variant 2, mRNA.	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)	16	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		ATCCATACTGGGGAGAAACCC	0.468000														30			3		0	0	6.4e-05	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729419	37729419	+	Silent	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr8:37729419C>A	uc003xkm.2	-	3	2957	c.2901G>T	c.(2899-2901)tcG>tcT	p.S967S	RAB11FIP1_uc003xkn.2_Intron|RAB11FIP1_uc003xkl.2_Silent_p.S296S|RAB11FIP1_uc003xko.1_Silent_p.S296S|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	Homo sapiens RAB11 family interacting protein 1 (class I) (RAB11FIP1), transcript variant 3, mRNA.	967					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TTTCATCATCCGATGCGACTT	0.453000														145			6		8.12818e-05	0.00916221	8.12818e-05	1	0
ZNF573	126231	broad.mit.edu	37	19	38230140	38230140	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr19:38230140C>A	uc002ohe.3	-	4	1320	c.1251G>T	c.(1249-1251)aaG>aaT	p.K417N	ZNF573_uc010efs.2_Missense_Mutation_p.K330N|ZNF573_uc002ohd.3_Missense_Mutation_p.K415N|ZNF573_uc002ohf.3_Missense_Mutation_p.K359N|ZNF573_uc002ohg.3_Missense_Mutation_p.K329N|ZNF573_uc021utv.1_Missense_Mutation_p.K329N	NM_001172690	NP_001166161	Q86YE8	ZN573_HUMAN	Homo sapiens zinc finger protein 573 (ZNF573), transcript variant 3, mRNA.	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TTCCGCATTCCTTGCATTCAT	0.378000														142			101		1.09008e-60	1.44883e-58	2.47226e-05	1	0
SMAD7	4092	broad.mit.edu	37	18	46447887	46447887	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr18:46447887C>T	uc002ldg.3	-	3	1423	c.1136G>A	c.(1135-1137)cGg>cAg	p.R379Q	SMAD7_uc002ldf.3_Missense_Mutation_p.R191Q|SMAD7_uc010xde.2_Missense_Mutation_p.R164Q|SMAD7_uc021ujr.1_Missense_Mutation_p.R378Q	NM_005904	NP_005895	O15105	SMAD7_HUMAN	Homo sapiens SMAD family member 7 (SMAD7), transcript variant 1, mRNA.	379	MH2.				BMP signaling pathway|adherens junction assembly|artery morphogenesis|cellular protein complex localization|negative regulation of BMP signaling pathway|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity|pathway-restricted SMAD protein phosphorylation|positive regulation of anti-apoptosis|positive regulation of cell-cell adhesion|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein stabilization|regulation of activin receptor signaling pathway|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	centrosome|cytosol|nucleolus|plasma membrane|transcription factor complex	I-SMAD binding|activin binding|beta-catenin binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	10	Colorectal(1;0.0518)					GTCATTGGGCCGCTGCAGGCT	0.582000														32			19		0	0	1.64113e-05	0	0
CELSR3	1951	broad.mit.edu	37	3	48668741	48668741	+	Splice_Site	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:48668741T>C	uc003cuf.1	-	44	11119	c.11119_splice	c.e44-1	p.L3707_splice	CELSR3_uc003cug.3_Splice_Site_p.L281_splice|CELSR3_uc011bbp.2_Splice_Site_p.L266_splice|CELSR3_uc010hke.3_Splice_Site_p.L153_splice|CELSR3_uc003cuk.3_Splice_Site_p.L195_splice|CELSR3_uc003cuh.3_Splice_Site_p.L302_splice|CELSR3_uc003cui.3_Splice_Site_p.L302_splice|CELSR3_uc003cuj.3_Splice_Site_p.L302_splice	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	Homo sapiens cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) (CELSR3), mRNA.	0					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|calcium ion binding|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCCGATGAGCTGTGGGAGAGG	0.577000														3			6		0	0	5.18039e-06	0	0
GFPT1	2673	broad.mit.edu	37	2	69553334	69553334	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr2:69553334A>T	uc002sfi.2	-	19	2270	c.2087T>A	c.(2086-2088)gTg>gAg	p.V696E	GFPT1_uc002sfh.3_Missense_Mutation_p.V678E	NM_001244710	NP_001231639	Q06210	GFPT1_HUMAN	Homo sapiens glutamine--fructose-6-phosphate transaminase 1 (GFPT1), transcript variant 1, mRNA.	696					UDP-N-acetylglucosamine biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						CTCTACAGTCACAGATTTGGC	0.343000														28			18		0	0	1.15919e-05	0	0
PRR12	57479	broad.mit.edu	37	19	50097991	50097991	+	Silent	SNP	G	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr19:50097991G>C	uc002poo.4	+	3	399	c.399G>C	c.(397-399)tcG>tcC	p.S133S		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	Homo sapiens proline rich 12 (PRR12), mRNA.	547	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TCTTCATCTCGGGTGCCCTGC	0.662000														13			10		0	0	1.49906e-05	0	0
NXF3	56000	broad.mit.edu	37	X	102337711	102337711	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chrX:102337711C>T	uc004eju.3	-	7	828	c.757G>A	c.(757-759)Gtc>Atc	p.V253I	NXF3_uc010noi.1_Missense_Mutation_p.V103I|NXF3_uc011mrw.1_Missense_Mutation_p.V253I|NXF3_uc011mrx.1_Missense_Mutation_p.V164I	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	Homo sapiens nuclear RNA export factor 3 (NXF3), mRNA.	253						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding	p.D252D(1)		NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						TCTTCATGGACGTCCAGGGAG	0.478000														4			69		0	0	2.47226e-05	0	0
ADAM28	10863	broad.mit.edu	37	8	24209520	24209520	+	Silent	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr8:24209520T>C	uc003xdy.3	+	20	2282	c.2199T>C	c.(2197-2199)caT>caC	p.H733H	ADAM28_uc011laa.2_Non-coding_Transcript|ADAM28_uc010lua.3_Silent_p.H420H	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	Homo sapiens ADAM metallopeptidase domain 28 (ADAM28), transcript variant 1, mRNA.	733					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGAAGCCCCATGTGTATGATC	0.378000														54			39		0	0	2.47226e-05	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376409	113376409	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:113376409T>C	uc003eam.3	-	6	4531	c.4120A>G	c.(4120-4122)Atg>Gtg	p.M1374V	KIAA2018_uc003eal.3_Missense_Mutation_p.M1318V	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	Homo sapiens KIAA2018 (KIAA2018), mRNA.	1374					regulation of transcription, DNA-dependent	membrane|nucleus	DNA binding|calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TGACTGACCATCATTTGAGTT	0.468000														42			31		0	0	2.90539e-05	0	0
SLC47A2	146802	broad.mit.edu	37	17	19610045	19610045	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr17:19610045C>G	uc002gwe.4	-	8	1040	c.865G>C	c.(865-867)Ggc>Cgc	p.G289R	SLC47A2_uc002gwg.4_Missense_Mutation_p.G253R|SLC47A2_uc002gwf.4_Missense_Mutation_p.G253R|SLC47A2_uc002gwh.4_Non-coding_Transcript|SLC47A2_uc002gwi.3_Non-coding_Transcript|SLC47A2_uc010cqs.1_Non-coding_Transcript|SLC47A2_uc010cqt.1_Non-coding_Transcript	NM_152908	NP_690872	Q86VL8	S47A2_HUMAN	Homo sapiens solute carrier family 47, member 2 (SLC47A2), transcript variant 1, mRNA.	289						integral to membrane|plasma membrane	drug:hydrogen antiporter activity	p.G289G(1)		endometrium(2)|kidney(3)|large_intestine(2)|lung(1)|ovary(1)	9	all_cancers(12;2.3e-05)|all_epithelial(12;0.0024)|Breast(13;0.245)					AAGAAGGGGCCCCAGTCCTGC	0.607000														25			26		0	0	1.7367e-05	0	0
ZMYND10	51364	broad.mit.edu	37	3	50379017	50379017	+	Nonsense_Mutation	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:50379017C>T	uc003dag.1	-	10	1381	c.1235G>A	c.(1234-1236)tGg>tAg	p.W412*	RASSF1_uc003dad.1_5'Flank|RASSF1_uc003dae.1_5'Flank|RASSF1_uc003daf.1_5'Flank|RASSF1_uc010hlk.1_5'Flank|RASSF1_uc011bdq.1_5'Flank|ZMYND10_uc010hll.1_Nonsense_Mutation_p.W407*	NM_015896	NP_056980	O75800	ZMY10_HUMAN	Homo sapiens zinc finger, MYND-type containing 10 (ZMYND10), mRNA.	412						cytoplasm	protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|urinary_tract(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GCAGCAATACCACTCATTCTG	0.572000										TSP Lung(30;0.18)				35			27		0	0	1.7367e-05	0	0
LRIG3	121227	broad.mit.edu	37	12	59271290	59271290	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr12:59271290C>A	uc001sqr.3	-	14	2674	c.2428G>T	c.(2428-2430)Gtc>Ttc	p.V810F	LRIG3_uc009zqh.3_Missense_Mutation_p.V750F|LRIG3_uc010ssh.2_Non-coding_Transcript	NM_153377	NP_700356	Q6UXM1	LRIG3_HUMAN	Homo sapiens leucine-rich repeats and immunoglobulin-like domains 3 (LRIG3), transcript variant 2, mRNA.	810						integral to membrane			LRIG3/ROS1(2)	breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(12)|liver(1)|lung(14)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48			GBM - Glioblastoma multiforme(1;1.17e-18)			ATGATCACGACACCCACAGTG	0.562000			T	ROS1	NSCLC									19			32		2.49991e-28	3.18025e-26	8.91981e-05	1	0
GATAD2A	54815	broad.mit.edu	37	19	19613195	19613195	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr19:19613195C>T	uc010xqt.2	+	10	1943	c.1631C>T	c.(1630-1632)aCg>aTg	p.T544M	GATAD2A_uc010xqu.2_Missense_Mutation_p.T173M|GATAD2A_uc010xqv.2_Missense_Mutation_p.T564M|GATAD2A_uc010xqw.2_Missense_Mutation_p.T347M	NM_017660	NP_060130	Q86YP4	P66A_HUMAN	Homo sapiens GATA zinc finger domain containing 2A (GATAD2A), mRNA.	544					DNA methylation|negative regulation of transcription, DNA-dependent	NuRD complex|nuclear speck	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						GTCCTGCACACGTTCAGTCCG	0.647000														47			31		0	0	3.70037e-05	0	0
ETV5	2119	broad.mit.edu	37	3	185766603	185766603	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:185766603G>A	uc003fpy.3	-	12	1549	c.1484C>T	c.(1483-1485)gCc>gTc	p.A495V	ETV5_uc003fpz.3_Missense_Mutation_p.A453V	NM_004454	NP_004445	P41161	ETV5_HUMAN	Homo sapiens ets variant 5 (ETV5), mRNA.	453					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|cervix(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	28	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			GGAGAAGAGGGCATCTGGGTC	0.582000			T	"""TMPRSS2, SCL45A3"""	Prostate									15			19		0	0	3.10358e-05	0	0
AKAP12	9590	broad.mit.edu	37	6	151626981	151626981	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr6:151626981C>G	uc011eep.2	+	2	502	c.262C>G	c.(262-264)Ctg>Gtg	p.L88V	AKAP12_uc003qoe.3_Missense_Mutation_p.L88V	NM_005100	NP_005091	Q02952	AKA12_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 12 (AKAP12), transcript variant 1, mRNA.	88					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GAAAGGAGCCCTGAACGGTCA	0.552000														18			12		0	0	6.40141e-05	0	0
abParts	0	broad.mit.edu	37	22	22661206	22661206	+	RNA	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr22:22661206T>C	uc021wml.1	+	28		c.2217T>C			abParts_uc011aiq.1_Non-coding_Transcript|abParts_uc011aip.2_Non-coding_Transcript|abParts_uc010gto.3_Non-coding_Transcript					Parts of antibodies, mostly variable regions.																		AGCTGAATCATGCAGAATTTG	0.408000														22			3		0	0	6.4e-05	0	0
MCM10	55388	broad.mit.edu	37	10	13222572	13222572	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr10:13222572A>C	uc001ima.3	+	6	1026	c.898A>C	c.(898-900)Ata>Cta	p.I300L	MCM10_uc001imb.3_Missense_Mutation_p.I299L|MCM10_uc001imc.3_Missense_Mutation_p.I299L	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	Homo sapiens minichromosome maintenance complex component 10 (MCM10), transcript variant 1, mRNA.	300					DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|cell cycle checkpoint	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						ATTTGGGGTTATATTGAAGAA	0.423000														80			69		0	0	2.47226e-05	0	0
C16orf59	80178	broad.mit.edu	37	16	2511752	2511752	+	Silent	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr16:2511752C>T	uc002cqh.3	+	4	641	c.610C>T	c.(610-612)Ctg>Ttg	p.L204L	C16orf59_uc002cqg.2_Silent_p.L37L|C16orf59_uc002cqi.3_Silent_p.L37L|C16orf59_uc010uwb.2_Silent_p.L37L	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	Homo sapiens chromosome 16 open reading frame 59 (C16orf59), mRNA.	204										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				CGACAGGCACCTGCTGCGGCT	0.607000														65			21		0	0	5.49717e-05	0	0
DSN1	79980	broad.mit.edu	37	20	35399580	35399580	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr20:35399580C>A	uc010gfr.3	-	2	424	c.51G>T	c.(49-51)atG>atT	p.M17I	DSN1_uc002xfz.3_Missense_Mutation_p.M17I|DSN1_uc002xfy.4_Intron|DSN1_uc010zvs.2_Intron|DSN1_uc002xga.3_Missense_Mutation_p.M17I|DSN1_uc002xgc.3_Missense_Mutation_p.M1I|DSN1_uc002xgb.3_Missense_Mutation_p.M1I	NM_001145316	NP_001138790	Q9H410	DSN1_HUMAN	Homo sapiens DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (DSN1), transcript variant 1, mRNA.	17					cell division|chromosome segregation|mitotic prometaphase	MIS12/MIND type complex|cytosol|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				GAGTCTTAGACATCACTGGTC	0.378000														188			86		7.68447e-34	9.91743e-32	2.47226e-05	1	0
CHMP1A	5119	broad.mit.edu	37	16	89717999	89717999	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr16:89717999G>C	uc002fnu.3	-	2	216	c.83C>G	c.(82-84)gCg>gGg	p.A28G	CHMP1A_uc002fnv.3_Silent_p.G21G	NM_002768	NP_002759	Q9HD42	CHM1A_HUMAN	Homo sapiens charged multivesicular body protein 1A (CHMP1A), transcript variant 2, mRNA.	28					cell division|gene silencing|mitotic chromosome condensation|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription by glucose|protein transport|transcription, DNA-dependent|vesicle-mediated transport	condensed nuclear chromosome|early endosome|endomembrane system|endosome membrane|microtubule organizing center|nuclear matrix	metallopeptidase activity|protein domain specific binding|zinc ion binding			endometrium(1)|large_intestine(1)|ovary(1)	3		all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.048)		GGCCTGCTCCGCCTTGGAGTC	0.572000														24			31		0	0	2.31628e-05	0	0
PCBD1	5092	broad.mit.edu	37	10	72643783	72643783	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr10:72643783T>C	uc001jrn.1	-	3	490	c.239A>G	c.(238-240)cAt>cGt	p.H80R		NM_000281	NP_000272	P61457	PHS_HUMAN	Homo sapiens pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (PCBD1), mRNA.	80	Substrate binding (By similarity).				L-phenylalanine catabolic process|regulation of transcription, DNA-dependent|tetrahydrobiopterin biosynthetic process|transcription, DNA-dependent	cytosol|nucleus	4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|transcription coactivator activity			breast(1)|endometrium(2)|large_intestine(1)	4						GGCACACTCATGGGTGCTCAG	0.512000														27			13		0	0	3.45872e-05	0	0
PSPHP1	8781	broad.mit.edu	37	7	55841071	55841071	+	RNA	SNP	A	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr7:55841071A>G	uc003tqy.3	+	0		c.200A>G								Homo sapiens mRNA for L-3-phosphoserine-phosphatase homologue.																		GCCTATTACAACTTGCTATAG	0.348000														10			6		0	0	3.59834e-05	0	0
abParts	0	broad.mit.edu	37	14	107276043	107276043	+	Splice_Site	SNP	G	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr14:107276043G>A	uc021ser.1	-	5		c.258_splice	c.e5-1							Parts of antibodies, mostly variable regions.																		CCTGGAGCCTGGGAAACCGAG	0.512000														6			5		0	0	1.23904e-05	0	0
URB2	9816	broad.mit.edu	37	1	229770859	229770859	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr1:229770859G>C	uc001hts.1	+	3	635	c.499G>C	c.(499-501)Gcc>Ccc	p.A167P	URB2_uc009xfd.1_Missense_Mutation_p.A167P	NM_014777	NP_055592	Q14146	URB2_HUMAN	Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae) (URB2), mRNA.	167						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						AGCTGTGGTAGCCCAGTTGTT	0.582000														2			18		0	0	8.00594e-06	0	0
SIX4	51804	broad.mit.edu	37	14	61190290	61190290	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr14:61190290A>C	uc001xfc.3	-	0	563	c.503T>G	c.(502-504)aTc>aGc	p.I168S	SIX4_uc010app.1_Missense_Mutation_p.I160S	NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	Homo sapiens SIX homeobox 4 (SIX4), mRNA.	168						nucleus				breast(5)|endometrium(1)|large_intestine(11)|liver(1)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		GCTCTCGAGGATGCTGTAGAG	0.692000														10			6		0	0	5.18039e-06	0	0
ZNF207	7756	broad.mit.edu	37	17	30696350	30696350	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr17:30696350A>T	uc010csz.3	+	11	1557	c.1210A>T	c.(1210-1212)Aat>Tat	p.N404Y	ZNF207_uc002hhj.4_Missense_Mutation_p.N401Y|ZNF207_uc002hhh.4_Missense_Mutation_p.N385Y|ZNF207_uc002hhi.4_Missense_Mutation_p.N370Y|ZNF207_uc002hhk.1_Missense_Mutation_p.N401Y|ZNF207_uc002hhl.1_Non-coding_Transcript			O43670	ZN207_HUMAN	Homo sapiens zinc finger protein 207 (ZNF207), transcript variant 3, mRNA.	385						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			GTATCAACGTAATCTTCCTCG	0.502000														39			42		0	0	8.96297e-05	0	0
GEN1	348654	broad.mit.edu	37	2	17955658	17955658	+	Nonsense_Mutation	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr2:17955658C>T	uc002rct.2	+	10	1265	c.1192C>T	c.(1192-1194)Cag>Tag	p.Q398*	SMC6_uc010exo.3_Intron|GEN1_uc010yjs.1_Nonsense_Mutation_p.Q398*|GEN1_uc002rcu.2_Nonsense_Mutation_p.Q398*	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Homo sapiens Gen endonuclease homolog 1 (Drosophila) (GEN1), transcript variant 1, mRNA.	398					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(6)|central_nervous_system(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TAATCAACTACAGCCAATTCG	0.348000								Homologous recombination						89			82		0	0	2.47226e-05	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27809595	27809595	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr12:27809595A>C	uc001ric.2	+	9	1213	c.836A>C	c.(835-837)gAa>gCa	p.E279A	PPFIBP1_uc010sjr.1_Missense_Mutation_p.E107A|PPFIBP1_uc001rib.2_Missense_Mutation_p.E248A|PPFIBP1_uc001ria.3_Missense_Mutation_p.E248A|PPFIBP1_uc001rid.2_Missense_Mutation_p.E126A|PPFIBP1_uc001rie.1_5'Flank	NM_177444	NP_803193	Q86W92	LIPB1_HUMAN	Homo sapiens PTPRF interacting protein, binding protein 1 (liprin beta 1) (PPFIBP1), transcript variant 2, mRNA.	279					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					AAGGAATCTGAAGTAAAAAGG	0.313000														73			66		0	0	2.47226e-05	0	0
C9orf123	90871	broad.mit.edu	37	9	7799724	7799724	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr9:7799724C>G	uc003zki.3	-	0	55	c.11G>C	c.(10-12)cGg>cCg	p.R4P	C9orf123_uc022bdi.1_Missense_Mutation_p.R4P|C9orf123_uc003zkj.3_Missense_Mutation_p.R4P			Q96GE9	CI123_HUMAN	Homo sapiens chromosome 9 open reading frame 123 (C9orf123), mRNA.	4						integral to membrane				lung(1)	1		all_cancers(3;0.0539)|Lung NSC(3;3.36e-05)|all_lung(3;0.000156)|all_epithelial(3;0.0356)		GBM - Glioblastoma multiforme(50;0.0561)		CTGGGACAACCGAGACCCCAT	0.642000														28			3		0	0	2.56e-06	0	0
FAM71A	149647	broad.mit.edu	37	1	212799448	212799448	+	RNA	SNP	G	T	T	rs149566937		TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr1:212799448G>T	uc010pth.1	-	0		c.666C>A			FAM71A_uc001hjk.3_Missense_Mutation_p.R410M			Q8IYT1	FA71A_HUMAN	Homo sapiens cDNA FLJ40118 fis, clone TESTI2009412.									p.R410K(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(7)|liver(1)|lung(12)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CAGCATGGAAGGGAGCGAACC	0.627000														7			22		1.37657e-19	1.70254e-17	2.27731e-05	1	0
ACOX2	8309	broad.mit.edu	37	3	58517532	58517532	+	Silent	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:58517532C>A	uc003dkl.3	-	5	766	c.591G>T	c.(589-591)cgG>cgT	p.R197R		NM_003500	NP_003491	Q99424	ACOX2_HUMAN	Homo sapiens acyl-CoA oxidase 2, branched chain (ACOX2), mRNA.	197					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|acyl-CoA dehydrogenase activity|pristanoyl-CoA oxidase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(55;0.000194)|Kidney(10;0.00255)|KIRC - Kidney renal clear cell carcinoma(10;0.00268)|OV - Ovarian serous cystadenocarcinoma(275;0.156)		GGGTGGCTGACCGTCCCACTG	0.612000														15			14		3.52763e-06	0.000402738	5.01169e-05	1	0
NUMA1	4926	broad.mit.edu	37	11	71723991	71723991	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr11:71723991G>T	uc001orl.1	-	14	4730	c.4558C>A	c.(4558-4560)Ctg>Atg	p.L1520M	NUMA1_uc009ysw.1_Missense_Mutation_p.L1083M|NUMA1_uc001ork.1_Intron|NUMA1_uc001orm.1_Missense_Mutation_p.L1520M|NUMA1_uc001orn.2_Missense_Mutation_p.L1083M|NUMA1_uc009ysx.1_Missense_Mutation_p.L1520M|NUMA1_uc001oro.1_Missense_Mutation_p.L1520M	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	Homo sapiens nuclear mitotic apparatus protein 1 (NUMA1), mRNA.	1520					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						CTCTCCTCCAGGACCTTGACC	0.602000			T	RARA	APL									30			22		4.35082e-09	5.03169e-07	1.64113e-05	1	0
PTK2	5747	broad.mit.edu	37	8	141745382	141745382	+	Silent	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr8:141745382C>T	uc003yvu.3	-	21	2308	c.1998G>A	c.(1996-1998)cgG>cgA	p.R666R	PTK2_uc003yvo.3_Silent_p.R294R|PTK2_uc011ljq.2_Silent_p.R361R|PTK2_uc003yvp.3_Silent_p.R334R|PTK2_uc003yvq.3_Silent_p.R192R|PTK2_uc003yvr.3_Silent_p.R606R|PTK2_uc003yvs.3_Silent_p.R666R|PTK2_uc011ljr.2_Silent_p.R666R|PTK2_uc003yvt.3_Silent_p.R688R|PTK2_uc003yvv.3_Silent_p.R566R|Mir_28_uc022bbw.1_5'Flank	NM_153831	NP_722560	Q05397	FAK1_HUMAN	Homo sapiens PTK2 protein tyrosine kinase 2 (PTK2), transcript variant 1, mRNA.	666	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|SH2 domain binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TAAACCTGGGCCGCCTGCTGG	0.532000														12			14		0	0	1.49906e-05	0	0
OR4C13	283092	broad.mit.edu	37	11	49974076	49974076	+	Silent	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr11:49974076C>A	uc010rhz.2	+	0	134	c.102C>A	c.(100-102)atC>atA	p.I34I		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily C, member 13 (OR4C13), mRNA.	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						TCATCTACATCAACGCCATGA	0.413000														242			32		2.08457e-15	2.54289e-13	4.66903e-05	1	0
IREB2	3658	broad.mit.edu	37	15	78765688	78765688	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr15:78765688G>A	uc002bdr.2	+	7	1150	c.988G>A	c.(988-990)Gtt>Att	p.V330I	IREB2_uc010unb.1_Missense_Mutation_p.V80I|IREB2_uc002bdq.3_Missense_Mutation_p.V330I	NM_004136	NP_004127	P48200	IREB2_HUMAN	Homo sapiens iron-responsive element binding protein 2 (IREB2), mRNA.	330							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AAACCCTTTTGTTACATCCAT	0.373000														49			42		0	0	8.96297e-05	0	0
XKR4	114786	broad.mit.edu	37	8	56435874	56435874	+	Silent	SNP	C	G	G	rs4263738		TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr8:56435874C>G	uc003xsf.3	+	2	1073	c.1041C>G	c.(1039-1041)gcC>gcG	p.A347A		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	Homo sapiens XK, Kell blood group complex subunit-related family, member 4 (XKR4), mRNA.	347						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TGTCCCTGGCCTGGGCCTTGG	0.562000														15			16		0	0	5.01169e-05	0	0
CES3	23491	broad.mit.edu	37	16	67000741	67000741	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr16:67000741C>A	uc002eqt.3	+	7	1114	c.1035C>A	c.(1033-1035)aaC>aaA	p.N345K	CES3_uc010cdz.3_Missense_Mutation_p.N345K|CES3_uc010viw.2_5'Flank	NM_024922	NP_079198	Q6UWW8	EST3_HUMAN	Homo sapiens carboxylesterase 3 (CES3), transcript variant 1, mRNA.	345						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GTGTCAACAACCATGAGTTCA	0.582000														113			65		1.52378e-38	1.99548e-36	2.47226e-05	1	0
KIAA1210	57481	broad.mit.edu	37	X	118223094	118223094	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chrX:118223094A>G	uc004era.4	-	10	2099	c.2099T>C	c.(2098-2100)aTc>aCc	p.I700T		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	Homo sapiens KIAA1210 (KIAA1210), mRNA.	700										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TTCTAACTGGATATGAGAAGG	0.443000														6			44		0	0	1.69351e-05	0	0
FAT1	2195	broad.mit.edu	37	4	187539870	187539870	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr4:187539870C>A	uc003izf.3	-	9	8058	c.7870G>T	c.(7870-7872)Gat>Tat	p.D2624Y		NM_005245	NP_005236	Q14517	FAT1_HUMAN	Homo sapiens FAT tumor suppressor homolog 1 (Drosophila) (FAT1), mRNA.	2624	Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GAGCCCTCATCGGCATCACTT	0.443000										HNSCC(5;0.00058)				39			32		4.4194e-11	5.2473e-09	7.24521e-05	1	0
TANC1	85461	broad.mit.edu	37	2	160084382	160084382	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr2:160084382T>G	uc002uag.3	+	24	4230	c.3956T>G	c.(3955-3957)tTt>tGt	p.F1319C	TANC1_uc010zcm.2_Missense_Mutation_p.F1311C|TANC1_uc010fom.1_Missense_Mutation_p.F1125C|TANC1_uc010fon.3_Missense_Mutation_p.F163C	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	Homo sapiens tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 (TANC1), transcript variant 1, mRNA.	1319						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						TTAAGAAAGTTTCCTCGAGAA	0.408000														33			37		0	0	1.8613e-05	0	0
TBC1D13	54662	broad.mit.edu	37	9	131565636	131565636	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr9:131565636C>G	uc010myj.3	+	7	774	c.651C>G	c.(649-651)atC>atG	p.I217M	TBC1D13_uc010myk.3_Intron|TBC1D13_uc010myl.3_Missense_Mutation_p.I36M	NM_018201	NP_060671	Q9NVG8	TBC13_HUMAN	Homo sapiens TBC1 domain family, member 13 (TBC1D13), mRNA.	217	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	6						TCCTGTTCATCTACGCCAAGC	0.552000														25			32		0	0	3.70037e-05	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1335258	1335258	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr5:1335258A>G	uc003jch.3	-	5	756	c.710T>C	c.(709-711)cTc>cCc	p.L237P	CLPTM1L_uc003jcg.3_Missense_Mutation_p.L104P	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	Homo sapiens CLPTM1-like (CLPTM1L), mRNA.	237					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GGACACGGTGAGGGGCAGCTC	0.627000														41			27		0	0	9.22233e-05	0	0
CCR2	729230	broad.mit.edu	37	3	46399085	46399085	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:46399085T>A	uc003cpn.4	+	1	552	c.67T>A	c.(67-69)Ttt>Att	p.F23I	CCR2_uc003cpm.4_Missense_Mutation_p.F23I|CCR2_uc021wxa.1_Missense_Mutation_p.F23I	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	Homo sapiens chemokine (C-C motif) receptor 2 (CCR2), transcript variant A, mRNA.	23					JAK-STAT cascade|T-helper 17 cell chemotaxis|astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			breast(3)|endometrium(1)|large_intestine(1)|liver(2)|lung(7)	14				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		AGTCACCACCTTTTTTGATTA	0.478000														114			112		0	0	2.47226e-05	0	0
ZBTB11	27107	broad.mit.edu	37	3	101370105	101370105	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:101370105C>T	uc003dve.4	-	10	3297	c.3067G>A	c.(3067-3069)Gta>Ata	p.V1023I		NM_014415	NP_055230	O95625	ZBT11_HUMAN	Homo sapiens zinc finger and BTB domain containing 11 (ZBTB11), mRNA.	1023					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TGTGCTAATACATAATTAACC	0.398000														85			66		0	0	2.47226e-05	0	0
C15orf53	400359	broad.mit.edu	37	15	38988925	38988925	+	Silent	SNP	G	C	C	rs146995135	byFrequency	TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr15:38988925G>C	uc001zkf.1	+	0	127	c.117G>C	c.(115-117)gcG>gcC	p.A39A		NM_207444	NP_997327	Q8NAA6	CO053_HUMAN	Homo sapiens chromosome 15 open reading frame 53 (C15orf53), mRNA.	39			A -> V (in dbSNP:rs11857596).							endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		GTCTCCAGGCGTCTGTTTGGA	0.542000														45			26		0	0	1.7367e-05	0	0
ZNF573	126231	broad.mit.edu	37	19	38230139	38230139	+	Nonsense_Mutation	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr19:38230139C>A	uc002ohe.3	-	4	1321	c.1252G>T	c.(1252-1254)Gaa>Taa	p.E418*	ZNF573_uc010efs.2_Nonsense_Mutation_p.E331*|ZNF573_uc002ohd.3_Nonsense_Mutation_p.E416*|ZNF573_uc002ohf.3_Nonsense_Mutation_p.E360*|ZNF573_uc002ohg.3_Nonsense_Mutation_p.E330*|ZNF573_uc021utv.1_Nonsense_Mutation_p.E330*	NM_001172690	NP_001166161	Q86YE8	ZN573_HUMAN	Homo sapiens zinc finger protein 573 (ZNF573), transcript variant 3, mRNA.	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TTTCCGCATTCCTTGCATTCA	0.378000														145			101		1.85156e-62	2.4982e-60	2.47226e-05	1	0
PGAM2	5224	broad.mit.edu	37	7	44105125	44105125	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr7:44105125C>A	uc003tjs.3	-	0	62	c.4G>T	c.(4-6)Gcc>Tcc	p.A2S		NM_000290	NP_000281	P15259	PGAM2_HUMAN	Homo sapiens phosphoglycerate mutase 2 (muscle) (PGAM2), mRNA.	2					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity			large_intestine(2)|lung(4)|ovary(1)|stomach(1)	8						CGGTGAGTGGCCATGGTGGCA	0.607000														47			29		6.90743e-12	8.31225e-10	1.48458e-05	1	0
URB2	9816	broad.mit.edu	37	1	229770863	229770863	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr1:229770863A>G	uc001hts.1	+	3	639	c.503A>G	c.(502-504)cAg>cGg	p.Q168R	URB2_uc009xfd.1_Missense_Mutation_p.Q168R	NM_014777	NP_055592	Q14146	URB2_HUMAN	Homo sapiens URB2 ribosome biogenesis 2 homolog (S. cerevisiae) (URB2), mRNA.	168						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GTGGTAGCCCAGTTGTTTGAG	0.582000														2			18		0	0	1.15919e-05	0	0
TMED4	222068	broad.mit.edu	37	7	44621125	44621125	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr7:44621125A>G	uc003tli.3	-	2	332	c.310T>C	c.(310-312)Tcc>Ccc	p.S104P	TMED4_uc003tlj.3_Missense_Mutation_p.S45P|TMED4_uc003tlk.3_Missense_Mutation_p.S104P|DQ574505_uc003tll.3_5'Flank	NM_182547	NP_872353	Q7Z7H5	TMED4_HUMAN	Homo sapiens transmembrane emp24 protein transport domain containing 4 (TMED4), mRNA.	104	GOLD.				positive regulation of I-kappaB kinase/NF-kappaB cascade|transport	endoplasmic reticulum membrane|integral to membrane	signal transducer activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GGCGTGTGGGAGGTGAACGTG	0.557000														29			32		0	0	1.8613e-05	0	0
DOCK11	139818	broad.mit.edu	37	X	117731503	117731503	+	Silent	SNP	A	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chrX:117731503A>T	uc004eqp.2	+	20	2436	c.2373A>T	c.(2371-2373)gcA>gcT	p.A791A	DOCK11_uc004eqq.2_Silent_p.A557A	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	Homo sapiens dedicator of cytokinesis 11 (DOCK11), mRNA.	791	DHR-1.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						TGAATGATGCAGAATCAAGAA	0.398000														2			70		0	0	2.47226e-05	0	0
IREB2	3658	broad.mit.edu	37	15	78765689	78765689	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr15:78765689T>C	uc002bdr.2	+	7	1151	c.989T>C	c.(988-990)gTt>gCt	p.V330A	IREB2_uc010unb.1_Missense_Mutation_p.V80A|IREB2_uc002bdq.3_Missense_Mutation_p.V330A	NM_004136	NP_004127	P48200	IREB2_HUMAN	Homo sapiens iron-responsive element binding protein 2 (IREB2), mRNA.	330							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		AACCCTTTTGTTACATCCATA	0.373000														50			43		0	0	1.69351e-05	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33095588	33095588	+	Splice_Site	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr13:33095588T>C	uc010abe.1	-	5	209	c.187_splice	c.e5-1	p.A63_splice	N4BP2L2_uc001uuj.2_Splice_Site_p.A8_splice|N4BP2L2_uc010tdz.1_Splice_Site_p.A48_splice|N4BP2L2_uc001uuk.4_Splice_Site_p.A492_splice	NM_033111	NP_149102	Q92802	N42L2_HUMAN	Homo sapiens NEDD4 binding protein 2-like 2 (N4BP2L2), transcript variant 1, mRNA.	492										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TCCTATGGCCTACACAAAGGA	0.338000														109			3		0	0	2.56e-06	0	0
FUT4	2526	broad.mit.edu	37	11	94278321	94278321	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr11:94278321A>C	uc001pez.3	+	0	1305	c.1022A>C	c.(1021-1023)gAc>gCc	p.D341A	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.2_5'Flank	NM_002033	NP_002024	P22083	FUT4_HUMAN	Homo sapiens fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (FUT4), mRNA.	341					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			central_nervous_system(2)|endometrium(2)|lung(1)|skin(2)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CACCCCGGCGACCCGCCCTCA	0.662000														4			3		0	0	8.12818e-05	0	0
FSTL1	11167	broad.mit.edu	37	3	120122159	120122159	+	Silent	SNP	A	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:120122159A>G	uc003eds.3	-	7	799	c.624T>C	c.(622-624)aaT>aaC	p.N208N	FSTL1_uc011bjh.2_Silent_p.N173N	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	Homo sapiens follistatin-like 1 (FSTL1), mRNA.	208	EF-hand 2.				BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		TCCAATCAGCATTTTCATCAG	0.438000														66			54		0	0	2.47226e-05	0	0
FAM65A	79567	broad.mit.edu	37	16	67576026	67576026	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr16:67576026G>A	uc010vjp.2	+	12	1583	c.1397G>A	c.(1396-1398)cGg>cAg	p.R466Q	FAM65A_uc010cei.2_Missense_Mutation_p.R288Q|FAM65A_uc002eth.3_Missense_Mutation_p.R446Q|FAM65A_uc010cej.3_Missense_Mutation_p.R450Q|FAM65A_uc002eti.2_Missense_Mutation_p.R409Q|FAM65A_uc010vjq.2_Missense_Mutation_p.R460Q|FAM65A_uc002etj.1_Missense_Mutation_p.R445Q|FAM65A_uc002etk.3_Missense_Mutation_p.R445Q	NM_001193523	NP_078795	Q6ZS17	FA65A_HUMAN	Homo sapiens family with sequence similarity 65, member A (FAM65A), transcript variant 3, mRNA.	450						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCCTACAGTCGGACTCTGAGC	0.632000														85			27		0	0	3.70037e-05	0	0
DTWD1	56986	broad.mit.edu	37	15	49926740	49926740	+	Missense_Mutation	SNP	T	G	G			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr15:49926740T>G	uc001zxq.3	+	4	693	c.416T>G	c.(415-417)cTc>cGc	p.L139R	DTWD1_uc001zxs.3_Missense_Mutation_p.L139R|DTWD1_uc001zxr.3_Missense_Mutation_p.L52R	NM_020234	NP_064619	Q8N5C7	DTWD1_HUMAN	Homo sapiens DTW domain containing 1 (DTWD1), transcript variant 1, mRNA.	139										endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;0.0384)		all cancers(107;3.27e-08)|GBM - Glioblastoma multiforme(94;7.6e-05)		TAGGTTGCACTCATTTTTCCT	0.299000														136			5		0	0	3.59834e-05	0	0
GPR113	165082	broad.mit.edu	37	2	26532908	26532908	+	Silent	SNP	C	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr2:26532908C>A	uc002rhe.4	-	12	3144	c.3144G>T	c.(3142-3144)gtG>gtT	p.V1048V	GPR113_uc010yky.1_Intron|GPR113_uc002rhb.1_Intron|GPR113_uc010eyk.1_Intron|GPR113_uc002rhc.1_Intron|GPR113_uc002rhd.1_Intron	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	Homo sapiens G protein-coupled receptor 113 (GPR113), transcript variant 1, mRNA.	1048					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAGCAACTCACCAGGGAGA	0.572000														49			41		1.12205e-10	1.31471e-08	2.47226e-05	1	0
HNF4G	3174	broad.mit.edu	37	8	76465335	76465335	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr8:76465335T>C	uc003yaq.3	+	5	677	c.407T>C	c.(406-408)aTt>aCt	p.I136T	HNF4G_uc003yar.3_Missense_Mutation_p.I173T	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	Homo sapiens hepatocyte nuclear factor 4, gamma (HNF4G), mRNA.	136					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	37	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ATTGCAAGTATTGGTGATGTC	0.358000														56			49		0	0	2.47226e-05	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33960785	33960785	+	Silent	SNP	C	T	T			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr1:33960785C>T	uc001bxj.4	+	7	3008	c.2841C>T	c.(2839-2841)atC>atT	p.I947I	ZSCAN20_uc009vui.3_Silent_p.I946I	NM_145238	NP_660281	P17040	ZSC20_HUMAN	Homo sapiens zinc finger and SCAN domain containing 20 (ZSCAN20), mRNA.	947					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CCAAGCTCATCACACACCAGA	0.527000														2			33		0	0	5.84002e-05	0	0
ANKRD13A	88455	broad.mit.edu	37	12	110457067	110457067	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr12:110457067T>C	uc001tpx.3	+	5	927	c.668T>C	c.(667-669)gTt>gCt	p.V223A	ANKRD13A_uc009zvl.1_Non-coding_Transcript|ANKRD13A_uc009zvm.2_Missense_Mutation_p.V223A|ANKRD13A_uc010sxw.2_Missense_Mutation_p.V223A	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	Homo sapiens ankyrin repeat domain 13A (ANKRD13A), mRNA.	223										endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(8)|lung(3)|urinary_tract(1)	16						AGCAGGGAAGTTGAGCGGCGG	0.438000														41			35		0	0	1.8613e-05	0	0
ITM2C	81618	broad.mit.edu	37	2	231741583	231741583	+	Silent	SNP	G	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr2:231741583G>C	uc002vqz.3	+	3	582	c.462G>C	c.(460-462)gcG>gcC	p.A154A	ITM2C_uc002vra.3_Silent_p.A107A|ITM2C_uc002vrb.3_Intron|ITM2C_uc002vrc.3_Silent_p.A43A|ITM2C_uc002vrd.3_Intron	NM_030926	NP_112188	Q9NQX7	ITM2C_HUMAN	Homo sapiens integral membrane protein 2C (ITM2C), transcript variant 1, mRNA.	154	BRICHOS.				negative regulation of neuron projection development|neuron differentiation	Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	beta-amyloid binding			cervix(2)|lung(1)|ovary(1)|skin(1)	5		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;8.47e-12)|all cancers(144;3.44e-09)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GTCTGACTGCGTACCATGATA	0.587000														49			46		0	0	8.96297e-05	0	0
FAM208A	23272	broad.mit.edu	37	3	56658883	56658883	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr3:56658883G>C	uc003did.4	-	20	4209	c.4108C>G	c.(4108-4110)Cag>Gag	p.Q1370E	FAM208A_uc003dib.4_Missense_Mutation_p.Q489E|FAM208A_uc003dic.4_Missense_Mutation_p.Q994E|FAM208A_uc003die.4_Missense_Mutation_p.Q1431E	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	Homo sapiens family with sequence similarity 208, member A (FAM208A), transcript variant 2, mRNA.	1431										NS(1)|breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(11)|prostate(3)|skin(1)	32						TGTCGTTGCTGTATGTTCTGA	0.383000														64			47		0	0	2.47226e-05	0	0
PSME4	23198	broad.mit.edu	37	2	54147352	54147352	+	Frame_Shift_Del	DEL	C	-	-			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr2:54147352delC	uc002rxp.2	-	18	2454	c.2398delG	c.(2398-2400)gatfs	p.D800fs	PSME4_uc010yop.1_Frame_Shift_Del_p.D686fs|PSME4_uc010yoq.1_Non-coding_Transcript|PSME4_uc010fbu.1_Frame_Shift_Del_p.D175fs|PSME4_uc010fbv.1_Intron|PSME4_uc021vho.1_Frame_Shift_Del_p.D785fs	NM_014614	NP_055429	Q14997	PSME4_HUMAN	Homo sapiens proteasome (prosome, macropain) activator subunit 4 (PSME4), mRNA.	800					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding	p.R800Q(1)		breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGTTTTCCATCCCCACAATGC	0.383													---	280	---	---	189	---					
RGS7BP	401190	broad.mit.edu	37	5	63905047	63905047	+	Frame_Shift_Del	DEL	T	-	-			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr5:63905047delT	uc003jtj.3	+	5	742	c.742delT	c.(742-744)ttcfs	p.F248fs	RGS7BP_uc011cqu.2_Frame_Shift_Del_p.F115fs	NM_001029875	NP_001025046	Q6MZT1	R7BP_HUMAN	Homo sapiens regulator of G-protein signaling 7 binding protein (RGS7BP), mRNA.	248					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		GAAGAGAAGGTTCTTTGGGCT	0.478													---	63	---	---	38	---					
BHMT	635	broad.mit.edu	37	5	78426827	78426828	+	Frame_Shift_Ins	INS	-	A	A			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr5:78426827_78426828insA	uc003kfu.4	+	7	1214_1215	c.1109_1110insA	c.(1108-1110)ccafs	p.P370fs	BHMT_uc011cti.2_Frame_Shift_Ins_p.P217fs	NM_001713	NP_001704	Q93088	BHMT1_HUMAN	Homo sapiens betaine--homocysteine S-methyltransferase (BHMT), mRNA.	370					protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	ATGTCAAAGCCAGATGGCTGGG	0.495													---	175	---	---	105	---					
FBXL21	26223	broad.mit.edu	37	5	135276238	135276238	+	RNA	DEL	A	-	-			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr5:135276238delA	uc021ydv.1	+	6		c.1032delA			FBXL21_uc003lbc.3_Non-coding_Transcript|FBXL21_uc021ydw.1_Non-coding_Transcript|FBXL21_uc021ydx.1_Non-coding_Transcript	NM_012159		Q9UKT6	FXL21_HUMAN	Homo sapiens F-box and leucine-rich repeat protein 21 (gene/pseudogene) (FBXL21), mRNA.						rhythmic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			large_intestine(5)|lung(4)	9			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ATCATCAATCAAAATTGAAGA	0.333													---	44	---	---	19	---					
PLEKHG1	57480	broad.mit.edu	37	6	151152656	151152656	+	Frame_Shift_Del	DEL	T	-	-	rs803411	byFrequency	TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr6:151152656delT	uc011eem.1	+	14	2674	c.2586delT	c.(2584-2586)actfs	p.T862fs	PLEKHG1_uc011eel.1_Frame_Shift_Del_p.T843fs|PLEKHG1_uc003qny.1_Frame_Shift_Del_p.T803fs|PLEKHG1_uc003qnz.2_Frame_Shift_Del_p.T803fs	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 1 (PLEKHG1), mRNA.	803					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ATCAGGCCACTCCCGATCATG	0.512													---	69	---	---	60	---					
OPLAH	26873	broad.mit.edu	37	8	145113801	145113801	+	Splice_Site	DEL	T	-	-			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr8:145113801delT	uc003zar.3	-	5	546	c.464_splice	c.e5-1	p.G155_splice	OPLAH_uc003zat.1_5'Flank	NM_017570	NP_060040	O14841	OPLA_HUMAN	Homo sapiens 5-oxoprolinase (ATP-hydrolysing) (OPLAH), mRNA.	155							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CCGTGCGGCCTTCCAGAAAAG	0.677													---	4	---	---	2	---					
KRT76	51350	broad.mit.edu	37	12	53170736	53170736	+	Frame_Shift_Del	DEL	T	-	-			TCGA-G7-6797-01A-11D-1961-08	TCGA-G7-6797-10A-01D-1962-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1bd2e14-32b6-4c57-bad1-59c0591876c2	5df531ff-b58f-4f9b-8103-b154da29a87c	g.chr12:53170736delT	uc001sax.3	-	0	394	c.340delA	c.(340-342)agtfs	p.S114fs		NM_015848	NP_056932	Q01546	K22O_HUMAN	Homo sapiens keratin 76 (KRT76), mRNA.	114	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ccaaaaccactacctactcct	0.607													---	31	---	---	24	---					
