Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LAMP1	3916	broad.mit.edu	37	13	113960803	113960803	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr13:113960803T>C	uc001vtm.1	+	1	346	c.65T>C	c.(64-66)cTc>cCc	p.L22P	LAMP1_uc010tka.1_Missense_Mutation_p.L22P	NM_005561	NP_005552	P11279	LAMP1_HUMAN	Homo sapiens lysosomal-associated membrane protein 1 (LAMP1), mRNA.	22				LLLLLGLMHCA -> PVAAARPHALS (in Ref. 1; AAA60382).		endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			TTGACAGGCCTCATGCATTGT	0.473000														150			3		0	0	0.000248	0	0
MYH15	22989	broad.mit.edu	37	3	108110610	108110610	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:108110610G>A	uc003dxa.1	-	37	5544	c.5487C>T	c.(5485-5487)tcC>tcT	p.S1829S		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	Homo sapiens myosin, heavy chain 15 (MYH15), mRNA.	1829						myofibril|myosin filament	ATP binding|actin binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CTCCTACCCTGGATTCTAGTT	0.473000														149			33		0	0	0.003271	0	0
MLL2	8085	broad.mit.edu	37	12	49433380	49433380	+	Silent	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:49433380C>G	uc001rta.4	-	31	8067	c.8067G>C	c.(8065-8067)ctG>ctC	p.L2689L		NM_003482	NP_003473	O14686	MLL2_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2), mRNA.	2689					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(38)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(121)|kidney(35)|large_intestine(22)|lung(78)|ovary(3)|pancreas(2)|prostate(13)|skin(7)|stomach(3)|upper_aerodigestive_tract(9)|urinary_tract(5)	366						GCCGAATCAGCAGCTCTCGTA	0.577000			"""N, F, Mis"""		"""medulloblastoma, renal"""					HNSCC(34;0.089)				18			6		0	0	0.006214	0	0
SCAMP2	10066	broad.mit.edu	37	15	75142970	75142970	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:75142970A>T	uc002azb.1	-	5	591	c.517T>A	c.(517-519)Tgg>Agg	p.W173R	SCAMP2_uc002aza.1_Missense_Mutation_p.W23R	NM_005697	NP_005688	O15127	SCAM2_HUMAN	Homo sapiens secretory carrier membrane protein 2 (SCAMP2), mRNA.	173					post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	9						CCCGAGAACCAGGCCAGGCAG	0.562000														64			18		0	0	0.007413	0	0
LRP5	4041	broad.mit.edu	37	11	68205929	68205929	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:68205929C>T	uc001ont.3	+	19	4202	c.4127C>T	c.(4126-4128)cCc>cTc	p.P1376L	LRP5_uc009ysg.3_Missense_Mutation_p.P786L	NM_002335	NP_002326	O75197	LRP5_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 5 (LRP5), mRNA.	1376					Wnt receptor signaling pathway involved in dorsal/ventral axis specification|adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ACCAAGCCGCCCTCAGACGAC	0.592000														54			16		0	0	0.001523	0	0
BPIFA1	51297	broad.mit.edu	37	20	31825663	31825663	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:31825663G>A	uc002wyt.4	+	1	216	c.146G>A	c.(145-147)gGa>gAa	p.G49E	BPIFA1_uc002wyu.4_Missense_Mutation_p.G49E|BPIFA1_uc002wyv.3_Missense_Mutation_p.G49E	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	Homo sapiens BPI fold containing family A, member 1 (BPIFA1), transcript variant 2, mRNA.	49					innate immune response	extracellular region	lipid binding										GGTCTTGCAGGAAGCTTGACA	0.557000														55			33		0	0	0.003271	0	0
OLAH	55301	broad.mit.edu	37	10	15107661	15107661	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr10:15107661G>A	uc001int.2	+	6	894	c.640G>A	c.(640-642)Ggc>Agc	p.G214S	ACBD7_uc010qby.1_Intron|OLAH_uc001inu.2_Missense_Mutation_p.G161S	NM_018324	NP_060794	Q9NV23	SAST_HUMAN	Homo sapiens oleoyl-ACP hydrolase (OLAH), transcript variant 1, mRNA.	161					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity	p.G213*(1)		endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						GGAATTTGGAGGCACCCCCAA	0.408000														42			16		0	0	0.004007	0	0
C22orf13	83606	broad.mit.edu	37	22	24938994	24938994	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr22:24938994A>T	uc003aal.2	-	5	981	c.871T>A	c.(871-873)Ttt>Att	p.F291I	C22orf13_uc003aah.2_Missense_Mutation_p.F235I|C22orf13_uc003aai.4_Missense_Mutation_p.F191I|C22orf13_uc003aaj.4_Missense_Mutation_p.F234I|C22orf13_uc003aak.4_Missense_Mutation_p.F290I	NM_031444	NP_113632	Q96NT3	CV013_HUMAN	Homo sapiens chromosome 22 open reading frame 13 (C22orf13), mRNA.	235										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	4						AAGTAGACAAAGAGGATGTCC	0.637000														65			27		0	0	0.006320	0	0
CDCA8	55143	broad.mit.edu	37	1	38174030	38174030	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:38174030C>T	uc001cbr.3	+	10	942	c.835C>T	c.(835-837)Cac>Tac	p.H279Y	CDCA8_uc001cbs.3_Missense_Mutation_p.H279Y	NM_018101	NP_060571	Q53HL2	BOREA_HUMAN	Homo sapiens cell division cycle associated 8 (CDCA8), mRNA.	279					cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding	p.T278I(1)		central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|skin(1)|stomach(1)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CATACGGACCCACAAATGAGA	0.483000														43			13		0	0	0.001855	0	0
TXLNA	200081	broad.mit.edu	37	1	32646099	32646099	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:32646099T>C	uc001bui.3	+	1	218	c.153T>C	c.(151-153)gcT>gcC	p.A51A	TXLNA_uc001buj.3_Silent_p.A51A	NM_175852	NP_787048	P40222	TXLNA_HUMAN	Homo sapiens taxilin alpha (TXLNA), mRNA.	51					cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GCAGCCAGGCTCCTCGGAAGC	0.701000														10			4		0	0	0.000248	0	0
UBAC2	337867	broad.mit.edu	37	13	99890774	99890774	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr13:99890774T>C	uc010tiu.2	+	1	609	c.274T>C	c.(274-276)Tgt>Cgt	p.C92R	UBAC2_uc001voa.4_Missense_Mutation_p.V42A|UBAC2_uc001vob.4_Missense_Mutation_p.C92R|UBAC2_uc010tiv.2_Non-coding_Transcript|UBAC2_uc001vod.3_5'UTR|UBAC2_uc001voc.3_Missense_Mutation_p.C84R|UBAC2_uc010tiw.2_Non-coding_Transcript|MIR548AN_uc021rly.1_Intron	NM_177967	NP_808882	Q8NBM4	UBAC2_HUMAN	Homo sapiens UBA domain containing 2 (UBAC2), transcript variant 2, mRNA.	72						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)	10	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					AAGCTCTTTGTGTATGACCTT	0.547000														209			64		0	0	0.003610	0	0
CHGB	1114	broad.mit.edu	37	20	5903930	5903930	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:5903930T>C	uc002wmg.3	+	3	1446	c.1140T>C	c.(1138-1140)agT>agC	p.S380S	CHGB_uc010zqz.2_Silent_p.S63S	NM_001819	NP_001810	P05060	SCG1_HUMAN	Homo sapiens chromogranin B (secretogranin 1) (CHGB), mRNA.	380						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						GTGAGGAGAGTTGGGATGAGG	0.547000														135			38		0	0	0.007835	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	RNA	SNP	C	A	A	rs79307257	by1000genomes	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:96593016C>A	uc010yug.1	-	26		c.1897G>T			ANKRD36C_uc002sva.1_Non-coding_Transcript|ANKRD36C_uc002svc.1_Non-coding_Transcript					Homo sapiens cDNA FLJ54441 complete cds, highly similar to Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000														65			4		0.000274275	0.000314793	0.004482	1	0
NAB2	4665	broad.mit.edu	37	12	57485457	57485457	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:57485457T>C	uc001smz.3	+	1	1011	c.633T>C	c.(631-633)ccT>ccC	p.P211P		NM_005967	NP_005958	Q15742	NAB2_HUMAN	Homo sapiens NGFI-A binding protein 2 (EGR1 binding protein 2) (NAB2), mRNA.	211					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity	p.P211P(6)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						TCTCCCCCCCTGCAGGGGGAG	0.711000														26			9		0	0	0.004007	0	0
POLR3B	55703	broad.mit.edu	37	12	106889911	106889911	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:106889911C>A	uc001tlp.3	+	23	3014	c.2792C>A	c.(2791-2793)cCa>cAa	p.P931Q	POLR3B_uc001tlq.3_Missense_Mutation_p.P873Q	NM_018082	NP_001154180	Q9NW08	RPC2_HUMAN	Homo sapiens polymerase (RNA) III (DNA directed) polypeptide B (POLR3B), transcript variant 1, mRNA.	931					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.P931P(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						ATCATGAACCCACACGGCTTC	0.488000														129			4		0.000602214	0.000675818	0.000602	1	0
HOXA10	3206	broad.mit.edu	37	7	27211695	27211695	+	Silent	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr7:27211695C>T	uc011jzm.2	-	1	1086	c.1056G>A	c.(1054-1056)gaG>gaA	p.E352E	HOXA9_uc022aar.1_Intron|MIR196B_uc022aas.1_5'Flank|HOXA10_uc003syw.4_Non-coding_Transcript	NM_018951	NP_061824	P31260	HXA10_HUMAN	Homo sapiens homeobox A10 (HOXA10), transcript variant 1, mRNA.	352					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	9						GAAACTCCTTCTCCAGCTCCA	0.532000														92			69		0	0	0.003610	0	0
LRRC40	55631	broad.mit.edu	37	1	70671136	70671136	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:70671136C>G	uc001der.2	-	0	226	c.88G>C	c.(88-90)Ggg>Cgg	p.G30R	SRSF11_uc009wbi.3_5'Flank|SRSF11_uc009wbj.1_5'Flank|SRSF11_uc010oqo.1_5'Flank|SRSF11_uc001det.3_5'Flank|SRSF11_uc001des.3_5'Flank	NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	Homo sapiens leucine rich repeat containing 40 (LRRC40), mRNA.	30										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(2)	27						TTCAACAGCCCTTGGGGTACC	0.562000														63			7		0	0	0.003080	0	0
ECEL1	9427	broad.mit.edu	37	2	233350797	233350797	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:233350797G>A	uc002vsv.2	-	1	772	c.567C>T	c.(565-567)gaC>gaT	p.D189D	ECEL1_uc010fya.1_Silent_p.D189D|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	Homo sapiens endothelin converting enzyme-like 1 (ECEL1), mRNA.	189					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCTCGCGCATGTCGAGGCACG	0.746000														19			5		0	0	0.001984	0	0
PTAFR	5724	broad.mit.edu	37	1	28477260	28477260	+	Silent	SNP	G	A	A	rs146920734		TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:28477260G>A	uc009vte.3	-	2	608	c.273C>T	c.(271-273)aaC>aaT	p.N91N	PTAFR_uc021ojz.1_Silent_p.N91N|PTAFR_uc001bpl.3_Silent_p.N91N|PTAFR_uc001bpm.4_Silent_p.N91N|PTAFR_uc021oka.1_Silent_p.N91N	NM_001164721	NP_001158195	P25105	PTAFR_HUMAN	Homo sapiens platelet-activating factor receptor (PTAFR), transcript variant 1, mRNA.	91					chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|stomach(1)	15		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		AGCCAGCCACGTTGCACAGGA	0.522000														44			26		0	0	0.003954	0	0
BRD2	6046	broad.mit.edu	37	6	32945266	32945266	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:32945266T>C	uc010juh.3	+	6	2552	c.1248T>C	c.(1246-1248)gcT>gcC	p.A416A	BRD2_uc003ocn.4_Silent_p.A416A|BRD2_uc003oco.3_Non-coding_Transcript|BRD2_uc003ocp.4_Silent_p.A296A|BRD2_uc003ocq.4_Silent_p.A416A|BRD2_uc021ywf.1_Silent_p.A369A	NM_001199455	NP_001186384	P25440	BRD2_HUMAN	Homo sapiens bromodomain containing 2 (BRD2), transcript variant 3, mRNA.	416	Bromo 2.				spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						AGTTTGCTGCTGATGTACGGC	0.517000														101			34		0	0	0.004878	0	0
GAPVD1	26130	broad.mit.edu	37	9	128121733	128121733	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr9:128121733G>A	uc004bpp.3	+	24	4247	c.4087G>A	c.(4087-4089)Gta>Ata	p.V1363I	GAPVD1_uc004bpq.3_Missense_Mutation_p.V1336I|GAPVD1_uc010mwx.3_Missense_Mutation_p.V1354I|GAPVD1_uc004bpr.3_Missense_Mutation_p.V1315I|GAPVD1_uc004bps.3_Missense_Mutation_p.V1309I|GAPVD1_uc004bpt.3_Missense_Mutation_p.V369I	NM_015635	NP_056450	Q14C86	GAPD1_HUMAN	Homo sapiens GTPase activating protein and VPS9 domains 1 (GAPVD1), mRNA.	1354	VPS9.				endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						ATTGTCTAAAGTAGTGACTGC	0.358000														98			27		0	0	0.008361	0	0
NRG1	3084	broad.mit.edu	37	8	32463201	32463201	+	Splice_Site	SNP	G	A	A	rs78513616		TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr8:32463201G>A	uc003xiv.2	+	3	917	c.400_splice	c.e3+1	p.E134_splice	NRG1_uc022ats.1_Splice_Site_p.A113_splice|NRG1_uc003xip.3_Splice_Site_p.A349_splice|NRG1_uc003xir.3_Splice_Site_p.E134_splice|NRG1_uc010lvl.3_Splice_Site_p.E134_splice|NRG1_uc010lvm.3_Splice_Site_p.A134_splice|NRG1_uc010lvn.3_Splice_Site_p.A134_splice|NRG1_uc003xis.3_Splice_Site_p.E134_splice|NRG1_uc011lbf.1_Splice_Site_p.E134_splice|NRG1_uc010lvo.2_Splice_Site_p.E134_splice|NRG1_uc003xiu.2_Splice_Site_p.E134_splice|NRG1_uc003xiw.2_Splice_Site_p.E134_splice|NRG1_uc003xit.2_Splice_Site_p.E134_splice|NRG1_uc010lvr.2_Splice_Site|NRG1_uc010lvs.2_Splice_Site|NRG1_uc010lvp.2_Splice_Site_p.E100_splice|NRG1_uc010lvq.2_Splice_Site_p.A93_splice|NRG1_uc003xix.3_Splice_Site_p.E24_splice	NM_013964	NP_039258	Q02297	NRG1_HUMAN	Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-alpha, mRNA.	134					Notch signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	ErbB-3 class receptor binding|cytokine activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GGAATCAAACGGTAAGAGATA	0.398000														86			20		0	0	0.008871	0	0
ARVCF	421	broad.mit.edu	37	22	19966432	19966432	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr22:19966432G>A	uc002zqz.3	-	6	1838	c.1568C>T	c.(1567-1569)tCg>tTg	p.S523L	ARVCF_uc002zqy.3_Missense_Mutation_p.S45L	NM_001670	NP_001661	O00192	ARVC_HUMAN	Homo sapiens armadillo repeat gene deleted in velocardiofacial syndrome (ARVCF), mRNA.	523					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CAGGCAGCCCGACGTGTTCTT	0.622000														28			7		0	0	0.003080	0	0
AMFR	267	broad.mit.edu	37	16	56401438	56401438	+	Splice_Site	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:56401438C>A	uc002eiy.3	-	12	1721	c.1516_splice	c.e12-1	p.R506_splice	AMFR_uc002eix.3_Splice_Site_p.R140_splice	NM_001144	NP_001135	Q9UKV5	AMFR2_HUMAN	Homo sapiens autocrine motility factor receptor (AMFR), mRNA.	506					ER-associated protein catabolic process|endoplasmic reticulum unfolded protein response|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17						GCTATCTGACCGCTGGAAGAG	0.498000														254			90		3.82636e-28	4.77114e-28	0.003610	1	0
ZFP14	57677	broad.mit.edu	37	19	36831515	36831515	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:36831515A>C	uc010xtd.2	-	3	1295	c.1216T>G	c.(1216-1218)Ttt>Gtt	p.F406V	ZFP14_uc010eex.2_Missense_Mutation_p.F405V	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	Homo sapiens zinc finger protein 14 homolog (mouse) (ZFP14), mRNA.	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TAACTACTAAAGGTCTTCCAA	0.408000														72			29		0	0	0.001786	0	0
DNAH8	1769	broad.mit.edu	37	6	38913344	38913344	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:38913344T>C	uc021yzh.1	+	79	12218	c.12109T>C	c.(12109-12111)Ttt>Ctt	p.F4037L	DNAH8_uc003ooe.2_Missense_Mutation_p.F3820L|DNAH8_uc003oog.1_Missense_Mutation_p.F269L|LOC100131047_uc003oof.2_Intron	NM_001206927	NP_001193856			Homo sapiens dynein, axonemal, heavy chain 8 (DNAH8), mRNA.											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACTTCCACAATTTGCAGAAAT	0.488000														71			32		0	0	0.002445	0	0
MECR	51102	broad.mit.edu	37	1	29520539	29520539	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:29520539T>A	uc001brq.1	-	9	1153	c.1117A>T	c.(1117-1119)Atg>Ttg	p.M373L	MECR_uc001brp.1_Missense_Mutation_p.M297L	NM_016011	NP_001019903	Q9BV79	MECR_HUMAN	Homo sapiens mitochondrial trans-2-enoyl-CoA reductase (MECR), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	373				M -> I (in Ref. 2; CAG32984).	fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)	11		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		GATGATCACATGGTGAGAATC	0.597000														59			28		0	0	0.008361	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334446	37334446	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr22:37334446C>T	uc003aqa.4	+	13	2813	c.2596C>T	c.(2596-2598)Ccc>Tcc	p.P866S	CSF2RB_uc003aqc.4_Missense_Mutation_p.P872S	NM_000395	NP_000386	P32927	IL3RB_HUMAN	Homo sapiens colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (CSF2RB), mRNA.	866					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CCAGGCTGTGCCCCAGGTGCC	0.587000														115			31		0	0	0.002836	0	0
CIR1	9541	broad.mit.edu	37	2	175215408	175215408	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:175215408T>C	uc002uim.3	-	8	750	c.657A>G	c.(655-657)aaA>aaG	p.K219K	CIR1_uc002uin.3_Silent_p.K93K	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	Homo sapiens corepressor interacting with RBPJ, 1 (CIR1), mRNA.	219	Interaction with RP9 (By similarity).|Lys/Ser-rich.				RNA splicing|mRNA processing|negative regulation of transcription, DNA-dependent	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						TCTGTTTTTGTTTGGTTGTTA	0.303000														48			4		0	0	0.000248	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482481	20482481	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:20482481C>G	uc010bwe.3	+	5	922	c.683C>G	c.(682-684)cCc>cGc	p.P228R	ACSM2A_uc010bwd.1_Intron|ACSM2A_uc010vax.1_Missense_Mutation_p.P149R|ACSM2A_uc002dhf.4_Missense_Mutation_p.P228R|ACSM2A_uc002dhg.4_Missense_Mutation_p.P228R|ACSM2A_uc010vay.2_Missense_Mutation_p.P149R	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	Homo sapiens acyl-CoA synthetase medium-chain family member 2A (ACSM2A), nuclear gene encoding mitochondrial protein, mRNA.	228					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding	p.P228S(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AGTGGTCTTCCCAAGATGGCA	0.507000														57			20		0	0	0.003954	0	0
APEH	327	broad.mit.edu	37	3	49720689	49720689	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:49720689A>G	uc010hkw.1	+	21	2528	c.2128A>G	c.(2128-2130)Agc>Ggc	p.S710G	APEH_uc003cxf.3_Missense_Mutation_p.S705G	NM_001640	NP_001631	P13798	ACPH_HUMAN	Homo sapiens N-acylaminoacyl-peptide hydrolase (APEH), mRNA.	705					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|skin(1)|stomach(2)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTATCCCAAAAGCACCCACGC	0.557000														227			53		0	0	0.003610	0	0
SLC35B2	347734	broad.mit.edu	37	6	44224125	44224125	+	Missense_Mutation	SNP	G	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:44224125G>C	uc003oxd.3	-	2	450	c.314C>G	c.(313-315)cCg>cGg	p.P105R	SLC35B2_uc011dvt.2_Intron|SLC35B2_uc011dvu.2_Intron|SLC35B2_uc021yzy.1_5'Flank	NM_178148	NP_835361	Q8TB61	S35B2_HUMAN	Homo sapiens solute carrier family 35, member B2 (SLC35B2), mRNA.	105					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	15	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CTGCCACATCGGGGTGGTCTC	0.627000														56			24		0	0	0.004656	0	0
GPR124	25960	broad.mit.edu	37	8	37692907	37692907	+	Missense_Mutation	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr8:37692907C>G	uc003xkj.3	+	11	2210	c.1824C>G	c.(1822-1824)ttC>ttG	p.F608L	GPR124_uc010lvy.3_Intron	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	Homo sapiens G protein-coupled receptor 124 (GPR124), mRNA.	608					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TGTCGTCCTTCCACATCAAGG	0.682000														14			10		0	0	0.008291	0	0
JAGN1	84522	broad.mit.edu	37	3	9934676	9934676	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:9934676G>A	uc003btt.4	+	1	303	c.167G>A	c.(166-168)aGc>aAc	p.S56N	CIDEC_uc003bto.3_Intron	NM_032492	NP_115881	Q8N5M9	JAGN1_HUMAN	Homo sapiens jagunal homolog 1 (Drosophila) (JAGN1), mRNA.	56						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|lung(3)|ovary(1)	10	Medulloblastoma(99;0.227)					GCTAAGATGAGCGTGGGACAC	0.512000														52			18		0	0	0.007413	0	0
FAM162A	26355	broad.mit.edu	37	3	122128621	122128621	+	Silent	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:122128621C>T	uc003eez.3	+	4	498	c.408C>T	c.(406-408)aaC>aaT	p.N136N		NM_014367	NP_055182	Q96A26	F162A_HUMAN	Homo sapiens family with sequence similarity 162, member A (FAM162A), mRNA.	136						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6						CAAGCTTGAACTTAGAAAAGA	0.438000														61			46		0	0	0.003610	0	0
CCDC62	84660	broad.mit.edu	37	12	123286278	123286278	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:123286278A>T	uc001udc.3	+	8	1747	c.1585A>T	c.(1585-1587)Atg>Ttg	p.M529L	CCDC62_uc010tah.2_Non-coding_Transcript|CCDC62_uc001ude.3_Missense_Mutation_p.M290L|CCDC62_uc021rfn.1_Missense_Mutation_p.M344L	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	Homo sapiens coiled-coil domain containing 62 (CCDC62), transcript variant 2, mRNA.	529						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		CCCAGGCCACATGTCTGACGT	0.502000														171			54		0	0	0.003610	0	0
SLC5A12	159963	broad.mit.edu	37	11	26725363	26725363	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:26725363A>C	uc001mra.2	-	4	970	c.657T>G	c.(655-657)aaT>aaG	p.N219K	SLC5A12_uc001mrb.2_Non-coding_Transcript|SLC5A12_uc001mrc.4_Missense_Mutation_p.N219K	NM_178498	NP_848593	Q1EHB4	SC5AC_HUMAN	Homo sapiens solute carrier family 5 (sodium/glucose cotransporter), member 12 (SLC5A12), mRNA.	219					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GTCGAGATCCATTTGTTGATT	0.368000														99			47		0	0	0.003610	0	0
HEATR3	55027	broad.mit.edu	37	16	50104088	50104088	+	Splice_Site	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:50104088G>A	uc002efw.3	+	4	562	c.400_splice	c.e4-1	p.C134_splice	HEATR3_uc021thv.1_Splice_Site_p.C48_splice|HEATR3_uc002efx.3_Splice_Site_p.C48_splice	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	Homo sapiens HEAT repeat containing 3 (HEATR3), mRNA.	134							binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						TTTGGTTACAGTGTAGTGCTG	0.383000														26			29		0	0	0.007291	0	0
RPH3A	22895	broad.mit.edu	37	12	113306301	113306301	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:113306301C>A	uc010syl.2	+	7	873	c.511C>A	c.(511-513)Cct>Act	p.P171T	RPH3A_uc001ttz.3_Missense_Mutation_p.P171T|RPH3A_uc001tty.3_Missense_Mutation_p.P167T|RPH3A_uc009zwe.1_Missense_Mutation_p.P167T|RPH3A_uc010sym.2_Missense_Mutation_p.P122T|RPH3A_uc001tua.3_5'UTR	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	Homo sapiens rabphilin 3A homolog (mouse) (RPH3A), transcript variant 1, mRNA.	171	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ACAGCCTATGCCTATAAAGAA	0.602000														41			12		2.27111e-07	2.69861e-07	0.001368	1	0
COL6A1	1291	broad.mit.edu	37	21	47423886	47423886	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr21:47423886G>A	uc002zhu.1	+	34	3148	c.3046G>A	c.(3046-3048)Gtc>Atc	p.V1016I	COL6A1_uc002zhv.1_Missense_Mutation_p.V347I	NM_001848	NP_001839	P12109	CO6A1_HUMAN	Homo sapiens collagen, type VI, alpha 1 (COL6A1), mRNA.	1016	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	GCTCCGCGGTGTCTTCCACCA	0.662000														71			49		0	0	0.003610	0	0
RANBP3	8498	broad.mit.edu	37	19	5941706	5941706	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:5941706T>C	uc002mdw.3	-	4	559	c.332A>G	c.(331-333)gAa>gGa	p.E111G	RANBP3_uc002mdx.3_Missense_Mutation_p.E111G|RANBP3_uc002mdy.3_Missense_Mutation_p.E43G|RANBP3_uc002mdz.3_Missense_Mutation_p.E43G|RANBP3_uc010duq.3_5'UTR|RANBP3_uc010xix.2_Intron	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-d, mRNA.	111					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	18						ATTTCCATCTTCTCTGTCAGA	0.423000														62			27		0	0	0.004656	0	0
TUBB1	81027	broad.mit.edu	37	20	57599037	57599037	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:57599037G>A	uc002yak.3	+	3	824	c.555G>A	c.(553-555)gcG>gcA	p.A185A		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	Homo sapiens tubulin, beta 1 class VI (TUBB1), mRNA.	185					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity	p.A185A(2)		endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|skin(2)	16	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	CCTACAACGCGGTTCTGTCTA	0.517000														144			21		0	0	0.001882	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453895	84453895	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr13:84453895G>A	uc001vlk.3	-	0	2634	c.1748C>T	c.(1747-1749)gCt>gTt	p.A583V		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	Homo sapiens SLIT and NTRK-like family, member 1 (SLITRK1), mRNA.	583						integral to membrane		p.A583S(1)		NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CGAGATCCTAGCGTACAGCTG	0.542000														23			8		0	0	0.004482	0	0
TXLNB	167838	broad.mit.edu	37	6	139563747	139563747	+	Silent	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:139563747T>C	uc021zfy.1	-	9	2136	c.1971A>G	c.(1969-1971)gcA>gcG	p.A657A		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	Homo sapiens taxilin beta (TXLNB), mRNA.	657						cytoplasm		p.R656*(1)		breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		CCTCTGCTGCTGCTCGTGGGG	0.642000														80			36		0	0	0.004878	0	0
PLXNA1	5361	broad.mit.edu	37	3	126730880	126730880	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:126730880A>C	uc003ejg.3	+	8	2192	c.2192A>C	c.(2191-2193)aAc>aCc	p.N731T		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	Homo sapiens plexin A1 (PLXNA1), mRNA.	731					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GCCGCACGGAACCTGCCACAG	0.627000														68			7		0	0	0.001855	0	0
abParts	0	broad.mit.edu	37	14	107062402	107062402	+	RNA	SNP	G	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr14:107062402G>C	uc021ser.1	-	150		c.6584C>G								Parts of antibodies, mostly variable regions.																		TCCTGGGCCCGACTCCTGCAG	0.597000														72			3		0	0	0.003080	0	0
ANP32C	23520	broad.mit.edu	37	4	165118517	165118517	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr4:165118517A>G	uc011cjk.2	-	0	347	c.347T>C	c.(346-348)cTt>cCt	p.L116P	MARCH1_uc003iqs.2_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	Homo sapiens acidic (leucine-rich) nuclear phosphoprotein 32 family, member C (ANP32C), mRNA.	116										NS(2)|breast(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(3)|skin(4)	35	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		GCAATTGAAAAGGTCTAAGCT	0.433000														189			3		0	0	0.004672	0	0
LRFN4	78999	broad.mit.edu	37	11	66625625	66625625	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:66625625C>T	uc001ojr.3	+	0	750	c.410C>T	c.(409-411)cCg>cTg	p.P137L	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojq.1_Missense_Mutation_p.P137L	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	Homo sapiens leucine rich repeat and fibronectin type III domain containing 4 (LRFN4), mRNA.	137						integral to membrane				breast(1)|lung(1)|prostate(1)	3						CGCATCGCGCCGGGAGCCTTC	0.692000														41			17		0	0	0.004990	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059041	79059041	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:79059041T>C	uc002bej.4	-	18	3423	c.3212A>G	c.(3211-3213)aAt>aGt	p.N1071S	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 7 (ADAMTS7), mRNA.	1071					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.N1071S(8)|p.N1071N(2)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CTCGTGGAAATTGATGAAATT	0.617000														30			3		0	0	0.000248	0	0
ZNF101	94039	broad.mit.edu	37	19	19789581	19789581	+	Silent	SNP	G	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:19789581G>C	uc002nni.2	+	2	287	c.177G>C	c.(175-177)ctG>ctC	p.L59L	ZNF101_uc010ecg.2_5'UTR|ZNF101_uc002nnj.2_5'UTR	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	Homo sapiens zinc finger protein 101 (ZNF101), mRNA.	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						ACCAAAACCTGGGGATTAAGC	0.333000														27			7		0	0	0.003080	0	0
CFHR1	3078	broad.mit.edu	37	1	196762617	196762617	+	Missense_Mutation	SNP	A	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:196762617A>T	uc001gtl.3	+	5	1054	c.967A>T	c.(967-969)Ata>Tta	p.I323L	CFH_uc021pgt.1_Intron|CFHR1_uc010poy.2_Missense_Mutation_p.I262L|CFHR1_uc001gtm.3_Intron	NM_021023	NP_066303	Q03591	FHR1_HUMAN	Homo sapiens complement factor H-related 3 (CFHR3), transcript variant 1, mRNA.	321	Sushi 5.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						TCGGGAAGGGATAGTGGAATA	0.383000														90			7		0	0	0.003080	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761006	27761006	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:27761006T>A	uc002dow.3	+	15	2749	c.2725T>A	c.(2725-2727)Tcc>Acc	p.S909T		NM_015202	NP_056017	O60303	K0556_HUMAN	Homo sapiens KIAA0556 (KIAA0556), mRNA.	909										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						CTTCGACCGCTCCCACCGGGG	0.637000														63			21		0	0	0.008871	0	0
HYDIN	54768	broad.mit.edu	37	16	70866949	70866949	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:70866949T>A	uc002ezr.3	-	79	13849	c.13698A>T	c.(13696-13698)aaA>aaT	p.K4566N	HYDIN_uc010cfy.3_Non-coding_Transcript	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	Homo sapiens HYDIN, axonemal central pair apparatus protein (HYDIN), transcript variant 1, mRNA.	4567										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GAGGCTCAAATTTTTTGATGT	0.413000														22			8		0	0	0.000978	0	0
PER3	8863	broad.mit.edu	37	1	7845603	7845603	+	Silent	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:7845603A>C	uc001aop.3	+	1	455	c.231A>C	c.(229-231)ctA>ctC	p.L77L	PER3_uc009vmg.1_Silent_p.L77L|PER3_uc009vmh.1_Silent_p.L77L|PER3_uc001aoo.3_Silent_p.L77L|PER3_uc010nzw.2_5'UTR|PER3_uc001aon.3_Silent_p.L77L	NM_016831	NP_058515	P56645	PER3_HUMAN	Homo sapiens period homolog 3 (Drosophila) (PER3), mRNA.	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CAAGCACTCTAGATGCCCTCA	0.448000														53			18		0	0	0.006122	0	0
SLC15A4	121260	broad.mit.edu	37	12	129283926	129283926	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr12:129283926A>G	uc001uhu.2	-	6	1504	c.1451T>C	c.(1450-1452)aTg>aCg	p.M484T	SLC15A4_uc001uhv.2_Non-coding_Transcript	NM_145648	NP_663623	Q8N697	S15A4_HUMAN	Homo sapiens solute carrier family 15, member 4 (SLC15A4), mRNA.	484					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|skin(1)	22	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		GGCACTCTGCATGGACTTGGG	0.512000														50			34		0	0	0.002836	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142481342	142481342	+	Missense_Mutation	SNP	G	C	C	rs146962136	by1000genomes	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr7:142481342G>C	uc011ksq.2	+	2	499	c.416G>C	c.(415-417)tGc>tCc	p.C139S	TCRBV2S1_uc003vzp.2_Intron|TCRBV3S1_uc011ksh.2_Intron|TCRBV3S1_uc003vzw.2_Intron|TCRBV3S1_uc011ksi.2_Intron|TCRBV3S1_uc010loj.2_Intron|TCRBV3S1_uc003wag.2_Intron|BV6S4-BJ2S2_uc003wan.1_Intron|PRSS3P2_uc011ksr.1_Non-coding_Transcript					Homo sapiens protease, serine, 3 pseudogene (TRY6), non-coding RNA.																		GGCACCGAGTGCCTTATCTCC	0.557000														44			3		0	0	0.000248	0	0
CFHR1	3078	broad.mit.edu	37	1	196762616	196762616	+	Silent	SNP	G	T	T	rs149081467		TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:196762616G>T	uc001gtl.3	+	5	1053	c.966G>T	c.(964-966)ggG>ggT	p.G322G	CFH_uc021pgt.1_Intron|CFHR1_uc010poy.2_Silent_p.G261G|CFHR1_uc001gtm.3_Intron	NM_021023	NP_066303	Q03591	FHR1_HUMAN	Homo sapiens complement factor H-related 3 (CFHR3), transcript variant 1, mRNA.	320	Sushi 5.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						GTCGGGAAGGGATAGTGGAAT	0.378000														90			7		1.06961e-07	1.28608e-07	0.003080	1	0
STK36	27148	broad.mit.edu	37	2	219556970	219556970	+	Silent	SNP	C	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:219556970C>G	uc002viu.3	+	14	2148	c.1869C>G	c.(1867-1869)ctC>ctG	p.L623L	STK36_uc002viv.3_Silent_p.L623L	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	Homo sapiens serine/threonine kinase 36 (STK36), transcript variant 1, mRNA.	623					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		TGGATGGGCTCCTTCATGGCT	0.537000														55			53		0	0	0.003610	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334445	37334445	+	Silent	SNP	G	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr22:37334445G>T	uc003aqa.4	+	13	2812	c.2595G>T	c.(2593-2595)gtG>gtT	p.V865V	CSF2RB_uc003aqc.4_Silent_p.V871V	NM_000395	NP_000386	P32927	IL3RB_HUMAN	Homo sapiens colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) (CSF2RB), mRNA.	865					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	GCCAGGCTGTGCCCCAGGTGC	0.592000														112			30		5.91797e-21	7.2892e-21	0.002445	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29884867	29884867	+	Missense_Mutation	SNP	T	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr16:29884867T>A	uc010vec.2	-	12	2533	c.2288A>T	c.(2287-2289)aAa>aTa	p.K763I	BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.4_Missense_Mutation_p.K693I|SEZ6L2_uc002dur.4_Missense_Mutation_p.K693I|SEZ6L2_uc002duq.4_Missense_Mutation_p.K763I|SEZ6L2_uc010ved.2_Missense_Mutation_p.K719I|SEZ6L2_uc002dus.4_Missense_Mutation_p.K649I	NM_001243332	NP_001230261	Q6UXD5	SE6L2_HUMAN	Homo sapiens seizure related 6 homolog (mouse)-like 2 (SEZ6L2), transcript variant 5, mRNA.	763	Sushi 4.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ACAGGCGCATTTGGGGACCCT	0.667000														45			10		0	0	0.008291	0	0
ATR	545	broad.mit.edu	37	3	142238533	142238533	+	Silent	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:142238533G>A	uc003eux.4	-	23	4482	c.4360C>T	c.(4360-4362)Cta>Tta	p.L1454L		NM_001184	NP_001175	Q13535	ATR_HUMAN	Homo sapiens ataxia telangiectasia and Rad3 related (ATR), mRNA.	1454					DNA damage checkpoint|DNA repair|DNA replication|cell cycle|cellular response to UV|cellular response to gamma radiation|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TGAGGTTCTAGTATTTCCCGA	0.363000								Other conserved DNA damage response genes						92			28		0	0	0.006320	0	0
PAPPA2	60676	broad.mit.edu	37	1	176740277	176740277	+	Missense_Mutation	SNP	G	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:176740277G>T	uc001gkz.3	+	16	5840	c.4676G>T	c.(4675-4677)gGg>gTg	p.G1559V	PAPPA2_uc009www.3_Non-coding_Transcript	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	Homo sapiens pappalysin 2 (PAPPA2), transcript variant 1, mRNA.	1559	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGCAAACCAGGGTACTATGTG	0.478000														47			18		0.000566183	0.000642522	0.004990	1	0
ACY1	95	broad.mit.edu	37	3	52022538	52022538	+	Splice_Site	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:52022538A>C	uc003dcp.3	+	13	1246	c.922_splice	c.e13-2	p.K308_splice	ACY1_uc011bea.2_Splice_Site_p.K398_splice|ACY1_uc003dcq.3_Splice_Site_p.K308_splice|ACY1_uc021wzb.1_Splice_Site_p.K273_splice|ACY1_uc021wzc.1_Splice_Site_p.K236_splice|ACY1_uc021wzd.1_Splice_Site_p.K243_splice	NM_000666	NP_001185824	Q03154	ACY1_HUMAN	Homo sapiens aminoacylase 1 (ACY1), transcript variant 1, mRNA.	308					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CCTGTCCCTCAGAAGTGGATG	0.562000														43			12		0	0	0.001855	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79059040	79059040	+	Silent	SNP	A	G	G	rs144043775	by1000genomes	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:79059040A>G	uc002bej.4	-	18	3424	c.3213T>C	c.(3211-3213)aaT>aaC	p.N1071N	ADAMTS7_uc010und.1_3'UTR	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 7 (ADAMTS7), mRNA.	1071					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.N1071S(6)|p.N1071N(4)		NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CCTCGTGGAAATTGATGAAAT	0.617000														30			3		0	0	0.000602	0	0
KRT13	3860	broad.mit.edu	37	17	39658827	39658827	+	Missense_Mutation	SNP	G	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr17:39658827G>A	uc002hwu.1	-	5	1106	c.1043C>T	c.(1042-1044)aCg>aTg	p.T348M	KRT13_uc002hwv.1_Missense_Mutation_p.T348M|KRT13_uc010wfr.2_Missense_Mutation_p.T241M|KRT13_uc010cxo.3_Missense_Mutation_p.T348M|KRT13_uc021txk.1_Missense_Mutation_p.T241M	NM_153490	NP_705694	P13646	K1C13_HUMAN	Homo sapiens keratin 13 (KRT13), transcript variant 1, mRNA.	348	Coil 2.|Rod.				epidermis development	intermediate filament	structural molecule activity	p.N347I(1)		NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				CTCTGCCACCGTGTTCTCCAG	0.632000														133			5		0	0	0.000602	0	0
STAB1	23166	broad.mit.edu	37	3	52554291	52554291	+	Nonsense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:52554291C>A	uc003dej.3	+	51	5558	c.5484C>A	c.(5482-5484)tgC>tgA	p.C1828*	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.3_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	Homo sapiens stabilin 1 (STAB1), mRNA.	1828	FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CTTTCTCCTGCAGCCGAACGC	0.632000														123			16		3.45872e-05	4.06198e-05	0.004007	1	0
OR6K2	81448	broad.mit.edu	37	1	158669896	158669896	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:158669896C>T	uc001fsu.1	-	0	547	c.547G>A	c.(547-549)Gtg>Atg	p.V183M		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	Homo sapiens olfactory receptor, family 6, subfamily K, member 2 (OR6K2), mRNA.	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					AGACGCAGCACTGGGAGGAAG	0.478000														63			29		0	0	0.001786	0	0
MOXD1	26002	broad.mit.edu	37	6	132694134	132694134	+	Missense_Mutation	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:132694134A>C	uc003qdf.3	-	2	513	c.414T>G	c.(412-414)gaT>gaG	p.D138E	MOXD1_uc003qde.3_Missense_Mutation_p.D70E	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	Homo sapiens monooxygenase, DBH-like 1 (MOXD1), transcript variant 2, mRNA.	138	DOMON.				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TCACAGTGCTATCCTGGGGAT	0.458000														63			25		0	0	0.006320	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855985	12855985	+	Missense_Mutation	SNP	T	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr1:12855985T>C	uc001auj.2	+	3	1368	c.1265T>C	c.(1264-1266)tTg>tCg	p.L422S		NM_023013	NP_075389	O95521	PRAM1_HUMAN	Homo sapiens PRAME family member 1 (PRAMEF1), mRNA.	422										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTGAATTCCTTGGTTCGTGTC	0.552000														151			7		0	0	0.001368	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr18:14513764C>T	uc010dln.3	-	9	1884	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q	POTEC_uc010xaj.2_Non-coding_Transcript	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	Homo sapiens POTE ankyrin domain family, member C (POTEC), mRNA.	477								p.R477Q(24)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000														66			4		0	0	0.001168	0	0
CDK5RAP3	80279	broad.mit.edu	37	17	46058013	46058013	+	Silent	SNP	C	T	T			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr17:46058013C>T	uc010wlc.2	+	11	1316	c.1192C>T	c.(1192-1194)Ctg>Ttg	p.L398L	CDK5RAP3_uc002imq.1_Silent_p.L153L|CDK5RAP3_uc002imr.3_Silent_p.L378L|CDK5RAP3_uc002ims.3_Silent_p.L291L	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	Homo sapiens CDK5 regulatory subunit associated protein 3 (CDK5RAP3), mRNA.	378					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding			NS(1)|central_nervous_system(2)|cervix(3)|endometrium(3)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	18						GGCAGATGTCCTGTCTGTGAG	0.527000														173			12		0	0	0.000978	0	0
GRB7	2886	broad.mit.edu	37	17	37898588	37898588	+	Missense_Mutation	SNP	A	G	G			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr17:37898588A>G	uc002hsr.3	+	1	309	c.34A>G	c.(34-36)Agc>Ggc	p.S12G	GRB7_uc002hss.3_Missense_Mutation_p.S12G|GRB7_uc021twu.1_Missense_Mutation_p.S35G|GRB7_uc010cwc.3_Missense_Mutation_p.S12G|GRB7_uc002hst.3_Missense_Mutation_p.S12G	NM_005310	NP_005301	Q14451	GRB7_HUMAN	Homo sapiens growth factor receptor-bound protein 7 (GRB7), transcript variant 1, mRNA.	12					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	SH3/SH2 adaptor activity|phosphatidylinositol binding|protein kinase binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCATCTTAGCAGCTCTCCGGA	0.617000														131			92		0	0	0.003610	0	0
EHMT2	10919	broad.mit.edu	37	6	31864742	31864742	+	Missense_Mutation	SNP	C	A	A			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:31864742C>A	uc003nxz.1	-	1	77	c.67G>T	c.(67-69)Gcg>Tcg	p.A23S	EHMT2_uc003nxy.1_5'Flank|EHMT2_uc011don.1_Missense_Mutation_p.A80S|EHMT2_uc003nya.1_Missense_Mutation_p.A23S|EHMT2_uc003nyb.1_Missense_Mutation_p.A23S|CFB_uc003nyc.2_5'Flank|CFB_uc011doo.2_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	Homo sapiens euchromatic histone-lysine N-methyltransferase 2 (EHMT2), transcript variant NG36/G9a, mRNA.	23					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						AGCAGCAGCGCCCCCATCTCA	0.637000														78			33		3.03874e-20	3.69774e-20	0.003271	1	0
HMGB3P1	128872	broad.mit.edu	37	20	33422211	33422211	+	RNA	SNP	A	C	C			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr20:33422211A>C	uc002xax.3	-	0		c.55T>G								Homo sapiens high mobility group box 3 pseudogene 1 (HMGB3P1), non-coding RNA.																		GTCTGCACAAAGAAGGCAAAA	0.433000														47			13		0	0	0.003163	0	0
KDM3A	55818	broad.mit.edu	37	2	86716748	86716749	+	In_Frame_Ins	INS	-	GGG	GGG			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr2:86716748_86716749insGGG	uc002sri.4	+	22	3866_3867	c.3539_3540insGGG	c.(3538-3540)aag>aaGGGg	p.1180_1181insG	KDM3A_uc010ytj.2_In_Frame_Ins_p.1180_1181insG|KDM3A_uc010ytk.2_In_Frame_Ins_p.1128_1129insG	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	Homo sapiens lysine (K)-specific demethylase 3A (KDM3A), transcript variant 1, mRNA.	1180	JmjC.				androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(3)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(3)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	47						TATGCTGCAAAGGACACGGAGA	0.406													---	84	---	---	51	---					
DAG1	1605	broad.mit.edu	37	3	49568641	49568641	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr3:49568641delA	uc021wxz.1	+	2	1166	c.697delA	c.(697-699)aacfs	p.N233fs	DAG1_uc021wya.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyb.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyc.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyd.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wye.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyf.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyg.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyh.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyi.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyj.1_Frame_Shift_Del_p.N233fs|DAG1_uc021wyk.1_Frame_Shift_Del_p.N233fs|DAG1_uc003cxc.4_Frame_Shift_Del_p.N233fs	NM_001177643	NP_001171114	Q14118	DAG1_HUMAN	Homo sapiens dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1), transcript variant 12, mRNA.	233	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of MAPKKK cascade|negative regulation of cell migration|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GGTGGTGAATAACAGACTATT	0.522													---	39	---	---	10	---					
N4BP2	55728	broad.mit.edu	37	4	40122970	40122970	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr4:40122970delA	uc003guy.4	+	8	3577	c.3239delA	c.(3238-3240)gaafs	p.E1080fs	N4BP2_uc010ifq.3_Frame_Shift_Del_p.E1000fs|N4BP2_uc010ifr.3_Frame_Shift_Del_p.E1000fs	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Homo sapiens NEDD4 binding protein 2 (N4BP2), mRNA.	1080						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TTTGTTGAAGAAAGTGAGCTT	0.338													---	72	---	---	25	---					
MRPL2	51069	broad.mit.edu	37	6	43023807	43023820	+	Splice_Site	DEL	GCCATCTCTCACCT	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr6:43023807_43023820delGCCATCTCTCACCT	uc003ots.1	-	4	643	c.520_splice	c.e4+1	p.V174_splice	CUL7_uc003otq.3_5'Flank|CUL7_uc011dvb.2_5'Flank|KLC4_uc003otr.1_Intron|MRPL2_uc011dvc.2_Frame_Shift_Del_p.A173fs	NM_015950	NP_057034	Q5T653	RM02_HUMAN	Homo sapiens mitochondrial ribosomal protein L2 (MRPL2), nuclear gene encoding mitochondrial protein, mRNA.	174					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(2)	9		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		ACATCTGGTAGCCATCTCTCACCTGCCATTCGGC	0.533													---	37	---	---	9	---					
PON2	5445	broad.mit.edu	37	7	95035516	95035516	+	Frame_Shift_Del	DEL	G	-	-	rs77619496	byFrequency	TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr7:95035516delG	uc003unv.3	-	7	942	c.821delC	c.(820-822)cctfs	p.P274fs	PON2_uc003unu.3_Frame_Shift_Del_p.P262fs|PON2_uc010lfk.3_Non-coding_Transcript|PON2_uc003unw.3_Frame_Shift_Del_p.P187fs	NM_000305	NP_000296	Q15165	PON2_HUMAN	Homo sapiens paraoxonase 2 (PON2), transcript variant 1, mRNA.	274					aromatic compound catabolic process	extracellular region|plasma membrane	arylesterase activity|identical protein binding|metal ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_cancers(62;9.35e-11)|all_epithelial(64;3.37e-09)		STAD - Stomach adenocarcinoma(171;0.0151)			CCCCGAGGAAGGATCAATAGA	0.398													---	233	---	---	13	---					
AHNAK	79026	broad.mit.edu	37	11	62293750	62293750	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr11:62293750delG	uc001ntl.3	-	4	8439	c.8139delC	c.(8137-8139)gacfs	p.D2713fs	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	Homo sapiens AHNAK nucleoprotein (AHNAK), transcript variant 1, mRNA.	2713					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCAGGTTTAAGTCAATATCAG	0.463													---	177	---	---	83	---					
CASC5	57082	broad.mit.edu	37	15	40914067	40914068	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:40914067_40914068delTT	uc010bbs.1	+	10	1844_1845	c.1683_1684delTT	c.(1681-1686)aattgtfs	p.N561fs	CASC5_uc010ucq.1_Frame_Shift_Del_p.N385fs|CASC5_uc001zme.3_Frame_Shift_Del_p.N535fs|CASC5_uc010bbt.1_Frame_Shift_Del_p.N535fs	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	Homo sapiens cancer susceptibility candidate 5 (CASC5), transcript variant 1, mRNA.	561	Interaction with BUB1 and BUB1B.				CenH3-containing nucleosome assembly at centromere|acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TGAATGTAAATTGTAACTCAGT	0.371													---	44	---	---	21	---					
SPTBN5	51332	broad.mit.edu	37	15	42178141	42178141	+	Frame_Shift_Del	DEL	G	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr15:42178141delG	uc001zos.3	-	6	1540	c.1207delC	c.(1207-1209)cggfs	p.R403fs		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	Homo sapiens spectrin, beta, non-erythrocytic 5 (SPTBN5), mRNA.	438					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		AAACTCTCCCGGAGGGCTGCC	0.667													---	4	---	---	2	---					
DNMT1	1786	broad.mit.edu	37	19	10250732	10250732	+	Frame_Shift_Del	DEL	A	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:10250732delA	uc002mng.3	-	31	3928	c.3748delT	c.(3748-3750)tccfs	p.S1250fs	DNMT1_uc002mnf.3_Frame_Shift_Del_p.S174fs|DNMT1_uc010xlc.2_Frame_Shift_Del_p.S1266fs|DNMT1_uc002mnh.3_Frame_Shift_Del_p.S1145fs|DNMT1_uc010xld.2_Frame_Shift_Del_p.S1250fs	NM_001379	NP_001370	P26358	DNMT1_HUMAN	Homo sapiens DNA (cytosine-5-)-methyltransferase 1 (DNMT1), transcript variant 2, mRNA.	1250	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CTGAGGAAGGAAACCACCAGA	0.612													---	42	---	---	10	---					
ZNF551	90233	broad.mit.edu	37	19	58265245	58265245	+	Frame_Shift_Del	DEL	T	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr19:58265245delT	uc002qpx.3	+	2	970	c.747delT	c.(745-747)aatfs	p.N249fs	ZNF587_uc002qqb.2_Intron|ZNF551_uc002qqa.3_Frame_Shift_Del_p.N249fs	NM_173632	NP_775903	Q7Z340	ZN551_HUMAN	Homo sapiens zinc finger protein 776 (ZNF776), mRNA.	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GCAAAAGTAATAGTTTTAATA	0.413													---	48	---	---	17	---					
C21orf7	56911	broad.mit.edu	37	21	30547133	30547133	+	Frame_Shift_Del	DEL	T	-	-			TCGA-G7-7502-01A-11D-2201-08	TCGA-G7-7502-10A-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ea718e65-433a-4e16-82fc-4f8e5be936af	2c767e98-3e53-4915-a687-2e67bc2cedc5	g.chr21:30547133delT	uc002ynf.3	+	8	926	c.649delT	c.(649-651)ttgfs	p.L217fs	C21orf7_uc011acr.2_Non-coding_Transcript|C21orf7_uc002ynd.3_Non-coding_Transcript|C21orf7_uc010gln.3_Non-coding_Transcript|C21orf7_uc002yne.3_Frame_Shift_Del_p.L217fs|C21orf7_uc010glo.3_Frame_Shift_Del_p.L62fs|C21orf7_uc002yng.3_Frame_Shift_Del_p.L117fs|C21orf7_uc010glp.3_Non-coding_Transcript	NM_020152	NP_064537	P57077	TAK1L_HUMAN	Homo sapiens chromosome 21 open reading frame 7 (C21orf7), mRNA.	217						cytosol|nucleus	protein binding			ovary(2)|prostate(1)	3				Colorectal(56;0.248)		GAATCGGACGTTGAGGTTGGC	0.488													---	46	---	---	19	---					
