Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EIF2AK4	440275	broad.mit.edu	37	15	40324962	40324962	+	Missense_Mutation	SNP	A	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr15:40324962A>G	uc001zkm.1	+	36	4783	c.4733A>G	c.(4732-4734)gAt>gGt	p.D1578G	EIF2AK4_uc010bbj.1_Missense_Mutation_p.D1279G|EIF2AK4_uc001zkn.1_Missense_Mutation_p.D678G|EIF2AK4_uc001zko.1_Missense_Mutation_p.D459G|EIF2AK4_uc010bbk.1_Non-coding_Transcript	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), mRNA.	1578					translation	cytosolic ribosome	ATP binding|aminoacyl-tRNA ligase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity	p.V1577V(1)		NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TCACAGGTGGATCTACCCAAA	0.388000														55			14		0	0	1	0	0
abParts	0	broad.mit.edu	37	14	107179222	107179222	+	RNA	SNP	G	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr14:107179222G>A	uc021ser.1	-	36		c.2202C>T								Parts of antibodies, mostly variable regions.																		CTCACAGGACGGGACAGTCAG	0.507000														48			11		0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34904710	34904710	+	Missense_Mutation	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr21:34904710C>T	uc002yrz.3	-	4	780	c.469G>A	c.(469-471)Ggg>Agg	p.G157R	GART_uc002yrx.3_Missense_Mutation_p.G157R|GART_uc010gmd.3_5'UTR|GART_uc002yry.3_Missense_Mutation_p.G157R|GART_uc002ysa.2_Missense_Mutation_p.G157R	NM_001136005	NP_001129478	P22102	PUR2_HUMAN	Homo sapiens phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (GART), transcript variant 3, mRNA.	157	ATP-grasp.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	ACAATCACCCCTTTTCCAGCT	0.428000														426			105		0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104117119	104117119	+	Silent	SNP	A	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr4:104117119A>C	uc003hxb.1	-	3	405	c.315T>G	c.(313-315)gtT>gtG	p.V105V	CENPE_uc003hxc.1_Silent_p.V105V	NM_001813	NP_001804	Q02224	CENPE_HUMAN	Homo sapiens centromere protein E, 312kDa (CENPE), mRNA.	105	Kinesin-motor.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CCCTGGGTATAACTCCCAAAT	0.358000														35			9		0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19201049	19201049	+	Missense_Mutation	SNP	A	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:19201049A>G	uc001bbb.3	-	13	1763	c.1487T>C	c.(1486-1488)gTg>gCg	p.V496A	ALDH4A1_uc010ocu.2_Missense_Mutation_p.V436A|ALDH4A1_uc001bbc.3_Missense_Mutation_p.V496A|ALDH4A1_uc021ohl.1_Missense_Mutation_p.V445A	NM_170726	NP_001154976	P30038	AL4A1_HUMAN	Homo sapiens aldehyde dehydrogenase 4 family, member A1 (ALDH4A1), nuclear gene encoding mitochondrial protein, transcript variant P5CDhS, mRNA.	496					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	ATTCCTCAGCACCTTTGTGGC	0.617000														192			55		0	0	1	0	0
KIAA1456	57604	broad.mit.edu	37	8	12879058	12879058	+	Silent	SNP	T	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr8:12879058T>C	uc010lsq.3	+	4	1362	c.870T>C	c.(868-870)tcT>tcC	p.S290S	KIAA1456_uc011kxw.2_Intron|KIAA1456_uc003wwj.4_Silent_p.S203S|KIAA1456_uc010lsr.3_Silent_p.S164S	NM_020844	NP_001093147	Q9P272	K1456_HUMAN	Homo sapiens KIAA1456 (KIAA1456), transcript variant 1, mRNA.	290							methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7						CCAGACACTCTAGTTTAGACT	0.423000														76			16		0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45669357	45669357	+	Silent	SNP	A	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr17:45669357A>T	uc002ilr.4	+	10	1519	c.1296A>T	c.(1294-1296)atA>atT	p.I432I	NPEPPS_uc010wkt.2_Silent_p.I428I|NPEPPS_uc010wku.2_Silent_p.I396I|NPEPPS_uc010wkv.2_5'UTR	NM_006310	NP_006301	P55786	PSA_HUMAN	Homo sapiens aminopeptidase puromycin sensitive (NPEPPS), mRNA.	432					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TTGATGAGATATTTGATGCTA	0.383000														79			13		0	0	1	0	0
RP2	6102	broad.mit.edu	37	X	46713306	46713306	+	Missense_Mutation	SNP	C	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chrX:46713306C>G	uc004dgw.4	+	1	687	c.498C>G	c.(496-498)atC>atG	p.I166M		NM_006915	NP_008846	O75695	XRP2_HUMAN	Homo sapiens retinitis pigmentosa 2 (X-linked recessive) (RP2), mRNA.	166	C-CAP/cofactor C-like.				CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process|cell morphogenesis|protein folding|visual perception	cytoplasm|plasma membrane	ATP binding|GTP binding|GTPase activator activity|nucleoside diphosphate kinase activity|unfolded protein binding			NS(1)|large_intestine(4)|lung(5)|stomach(1)	11						GGCTAAGTATCTTCAACAATA	0.403000														181			31		0	0	1	0	0
DDX11L11	0	broad.mit.edu	37	12	92920	92920	+	Missense_Mutation	SNP	C	G	G	rs145563795	by1000genomes	TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr12:92920C>G	uc010sdi.1	-	0	99	c.71G>C	c.(70-72)aGt>aCt	p.S24T	DDX11L11_uc010sdj.1_Non-coding_Transcript					SubName: Full=DEAD/H box polypeptide 11 like 11;																		ACTCACAAGACTGTGATCCAA	0.622000														30			5		0	0	1	0	0
IL6ST	3572	broad.mit.edu	37	5	55247844	55247844	+	Missense_Mutation	SNP	C	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr5:55247844C>G	uc003jqq.3	-	12	1925	c.1612G>C	c.(1612-1614)Gag>Cag	p.E538Q	IL6ST_uc003jqp.3_Intron|IL6ST_uc010iwd.3_Intron|IL6ST_uc011cqk.2_Missense_Mutation_p.E249Q|IL6ST_uc003jqr.3_3'UTR|IL6ST_uc010iwb.3_Missense_Mutation_p.E477Q|IL6ST_uc010iwe.1_5'Flank	NM_002184	NP_002175	P40189	IL6RB_HUMAN	Homo sapiens interleukin 6 signal transducer (gp130, oncostatin M receptor) (IL6ST), transcript variant 1, mRNA.	538	Fibronectin type-III 5.				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of T cell proliferation|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				TGGTCCCACTCTAAGACAGCT	0.348000			O		hepatocellular ca									50			6		0	0	1	0	0
EIF4A1	1973	broad.mit.edu	37	17	7478578	7478578	+	Splice_Site	SNP	T	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr17:7478578T>G	uc002gho.2	+	15	2908	c.345_splice	c.e15+2	p.Q115_splice	EIF4A1_uc002ghr.1_Splice_Site_p.Q115_splice|SNORD10_uc002ght.3_5'Flank|SNORA67_uc010cml.1_5'Flank	NM_001416	NP_001407	P60842	IF4A1_HUMAN	Homo sapiens eukaryotic translation initiation factor 4A1 (EIF4A1), transcript variant 1, mRNA.	115	Helicase ATP-binding.				nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|RNA cap binding|mRNA binding|protein binding|translation initiation factor activity			NS(1)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	22						GCTCAGCAGGTAAGAGTGGCT	0.488000														135			37		0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149433707	149433707	+	Missense_Mutation	SNP	A	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr5:149433707A>T	uc003lrl.3	-	20	3039	c.2844T>A	c.(2842-2844)agT>agA	p.S948R	CSF1R_uc011dcd.2_3'UTR|CSF1R_uc010jhc.3_Non-coding_Transcript|CSF1R_uc003lrm.3_Missense_Mutation_p.S948R	NM_005211	NP_005202	P07333	CSF1R_HUMAN	Homo sapiens colony stimulating factor 1 receptor (CSF1R), mRNA.	948					cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	TCAGGTGCTCACTAGAGCTCT	0.602000														47			13		0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17495608	17495608	+	Silent	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr10:17495608C>T	uc001ipd.3	-	1	150	c.150G>A	c.(148-150)gcG>gcA	p.A50A	ST8SIA6_uc010qce.2_Non-coding_Transcript	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	Homo sapiens ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 (ST8SIA6), mRNA.	50					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						GCGTCCTCAGCGCTGCGGGGG	0.706000														12			7		0	0	1	0	0
KIAA0284	283638	broad.mit.edu	37	14	105349547	105349547	+	Silent	SNP	T	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr14:105349547T>C	uc001yps.3	+	6	849	c.543T>C	c.(541-543)gaT>gaC	p.D181D	KIAA0284_uc010axb.3_Silent_p.D181D	NM_015005	NP_055820	Q9Y4F5	K0284_HUMAN	Homo sapiens KIAA0284 (KIAA0284), transcript variant 2, mRNA.	251						cytoplasm|microtubule		p.T180T(1)|p.T180M(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(5)|prostate(3)|soft_tissue(1)	14		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CCACGAAGGATGCAGAGGCAG	0.662000														84			8		0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19176018	19176018	+	Missense_Mutation	SNP	G	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:19176018G>T	uc001bba.1	-	3	1285	c.1284C>A	c.(1282-1284)aaC>aaA	p.N428K		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	Homo sapiens taste receptor, type 1, member 2 (TAS1R2), mRNA.	428					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GGAGAGTGAAGTTGACCTTCC	0.552000														81			25		3.6726e-16	4.01161e-16	1	1	0
PCDHGC5	56097	broad.mit.edu	37	5	140712677	140712677	+	Missense_Mutation	SNP	A	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr5:140712677A>G	uc011dan.2	+	0	2426	c.2426A>G	c.(2425-2427)aAc>aGc	p.N809S	PCDHGC5_uc003lji.2_Intron	NM_031993	NP_114382	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily A, 1 (PCDHGA1), transcript variant 2, mRNA.	0					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCAGGTAAACTTTTGTGAT	0.388000														135			33		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	116987	116987	+	RNA	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chrGL000205.1:116987C>T	uc002kgk.4	+	0		c.365C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GTTTCATCACCTTAAATGGTT	0.478000														23			5		0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237617770	237617770	+	Missense_Mutation	SNP	G	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:237617770G>T	uc001hyl.1	+	14	1492	c.1372G>T	c.(1372-1374)Gat>Tat	p.D458Y		NM_001035	NP_001026	Q92736	RYR2_HUMAN	Homo sapiens ryanodine receptor 2 (cardiac) (RYR2), mRNA.	458					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGTCTGCAGGATCTCATTGG	0.463000														76			20		0.000132079	0.000137906	1	1	0
FLG	2312	broad.mit.edu	37	1	152277075	152277075	+	Missense_Mutation	SNP	C	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:152277075C>A	uc001ezu.1	-	2	10323	c.10287G>T	c.(10285-10287)gaG>gaT	p.E3429D		NM_002016	NP_002007	P20930	FILA_HUMAN	Homo sapiens filaggrin (FLG), mRNA.	3429	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.Q3428K(1)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGACCCTCTTGGGACG	0.612000									Ichthyosis					673			146		6.59341e-128	7.55052e-128	1	1	0
APOB	338	broad.mit.edu	37	2	21238283	21238283	+	Missense_Mutation	SNP	G	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr2:21238283G>A	uc002red.3	-	21	3595	c.3467C>T	c.(3466-3468)gCt>gTt	p.A1156V		NM_000384	NP_000375	P04114	APOB_HUMAN	Homo sapiens apolipoprotein B (including Ag(x) antigen) (APOB), mRNA.	1156					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGAGCCATAAGCTGTAGCAGA	0.507000														151			32		0	0	1	0	0
ZNF419	79744	broad.mit.edu	37	19	58005060	58005060	+	Missense_Mutation	SNP	T	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr19:58005060T>G	uc010ety.1	+	4	1378	c.1138T>G	c.(1138-1140)Ttt>Gtt	p.F380V	ZNF419_uc002qov.2_Missense_Mutation_p.F379V|ZNF419_uc010etz.1_Missense_Mutation_p.F367V|ZNF419_uc002qow.2_Missense_Mutation_p.F347V|ZNF419_uc010eua.1_Missense_Mutation_p.F366V|ZNF419_uc010eub.1_Missense_Mutation_p.F334V|ZNF419_uc010euc.1_Missense_Mutation_p.F333V	NM_001098491	NP_001091961	Q96HQ0	ZN419_HUMAN	Homo sapiens zinc finger protein 419 (ZNF419), transcript variant 1, mRNA.	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		CTGTGGGAAATTTTTTACCCA	0.408000														164			41		0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141607702	141607702	+	Silent	SNP	G	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr2:141607702G>A	uc002tvj.1	-	28	5880	c.4908C>T	c.(4906-4908)aaC>aaT	p.N1636N	LRP1B_uc010fnl.1_Silent_p.N818N	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 1B (LRP1B), mRNA.	1636					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCCAGTTCCGTTAATAAAAG	0.318000										TSP Lung(27;0.18)				91			20		0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47117430	47117430	+	Missense_Mutation	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr16:47117430C>T	uc002eer.2	-	8	1693	c.1280G>A	c.(1279-1281)cGc>cAc	p.R427H	NETO2_uc002eeq.2_Missense_Mutation_p.R162H|NETO2_uc010vgf.2_Missense_Mutation_p.R420H	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	Homo sapiens neuropilin (NRP) and tolloid (TLL)-like 2 (NETO2), transcript variant 1, mRNA.	427						integral to membrane	receptor activity	p.R426W(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				GGTGGAGGAGCGCCGCATCTT	0.537000										HNSCC(25;0.065)				262			66		0	0	1	0	0
ANAPC5	51433	broad.mit.edu	37	12	121766167	121766167	+	Missense_Mutation	SNP	T	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr12:121766167T>C	uc001uag.3	-	9	1378	c.1256A>G	c.(1255-1257)gAt>gGt	p.D419G	ANAPC5_uc010szu.2_Missense_Mutation_p.D85G|ANAPC5_uc001uae.3_5'UTR|ANAPC5_uc010szv.2_Missense_Mutation_p.D21G|ANAPC5_uc001uaf.3_Non-coding_Transcript|ANAPC5_uc001uah.3_Missense_Mutation_p.D307G	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	Homo sapiens anaphase promoting complex subunit 5 (ANAPC5), transcript variant 1, mRNA.	419					G2/M transition of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(6)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(3)	31	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GATGCTGATATCGATGAGCTC	0.547000														90			17		0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31762754	31762754	+	Missense_Mutation	SNP	G	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr6:31762754G>T	uc003nxe.3	-	1	664	c.241C>A	c.(241-243)Cca>Aca	p.P81T	VARS_uc011doi.1_Intron	NM_006295	NP_006286	P26640	SYVC_HUMAN	Homo sapiens valyl-tRNA synthetase (VARS), nuclear gene encoding mitochondrial protein, mRNA.	81					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	AGGCCTGCTGGCCACAGCAGC	0.711000														57			13		0.00185496	0.00188146	1	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904238	144904238	+	Nonsense_Mutation	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chrX:144904238C>T	uc022cfn.1	+	0	295	c.295C>T	c.(295-297)Cag>Tag	p.Q99*	SLITRK2_uc004fcd.3_Nonsense_Mutation_p.Q99*|SLITRK2_uc010nsp.3_Nonsense_Mutation_p.Q99*|SLITRK2_uc010nso.3_Nonsense_Mutation_p.Q99*|SLITRK2_uc011mwq.2_Nonsense_Mutation_p.Q99*|SLITRK2_uc011mwr.2_Nonsense_Mutation_p.Q99*|SLITRK2_uc011mws.2_Nonsense_Mutation_p.Q99*|SLITRK2_uc004fcg.3_Nonsense_Mutation_p.Q99*|SLITRK2_uc011mwt.2_Nonsense_Mutation_p.Q99*	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	Homo sapiens SLIT and NTRK-like family, member 2 (SLITRK2), transcript variant 1, mRNA.	99						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					CAACGGGTTACAGGAGATCCG	0.458000														176			46		0	0	1	0	0
MED24	9862	broad.mit.edu	37	17	38187790	38187790	+	Splice_Site	SNP	C	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr17:38187790C>G	uc002hts.3	-	10	1342	c.1142_splice	c.e10+1	p.N381_splice	MED24_uc010wes.2_Splice_Site_p.N216_splice|MED24_uc010wet.2_Intron|MED24_uc002htt.3_Splice_Site_p.N356_splice|MED24_uc002htu.3_Splice_Site_p.N343_splice|MED24_uc010cwn.3_Splice_Site_p.N343_splice|MED24_uc010weu.2_Splice_Site_p.N266_splice|MED24_uc010wev.1_Splice_Site_p.N306_splice|MED24_uc010wew.1_Splice_Site_p.N285_splice|MED24_uc010wex.1_Splice_Site_p.N61_splice	NM_014815	NP_055630	O75448	MED24_HUMAN	Homo sapiens mediator complex subunit 24 (MED24), transcript variant 1, mRNA.	356					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	RNA polymerase II transcription cofactor activity|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|thyroid hormone receptor binding|vitamin D receptor binding			autonomic_ganglia(1)|breast(2)|endometrium(9)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	41	Colorectal(19;0.000442)					GGAGCTCATACTTGCAGCGCT	0.557000														255			42		0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3334451	3334451	+	Silent	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:3334451C>T	uc001akf.3	+	10	2833	c.2751C>T	c.(2749-2751)gaC>gaT	p.D917D	PRDM16_uc001ake.3_Silent_p.D917D|PRDM16_uc009vlh.3_Silent_p.D617D|PRDM16_uc001akc.3_Silent_p.D916D	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	Homo sapiens PR domain containing 16 (PRDM16), transcript variant 1, mRNA.	917	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TGAAGGCGGACTCGGGCAGCT	0.602000			T	EVI1	"""MDS, AML"""									214			71		0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167742778	167742778	+	Missense_Mutation	SNP	T	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr3:167742778T>C	uc011bpe.1	-	12	2076	c.1732A>G	c.(1732-1734)Aat>Gat	p.N578D	GOLIM4_uc003ffe.2_Missense_Mutation_p.N577D|GOLIM4_uc011bpf.1_Missense_Mutation_p.N550D|GOLIM4_uc011bpg.1_Missense_Mutation_p.N549D	NM_014498	NP_055313	O00461	GOLI4_HUMAN	Homo sapiens golgi integral membrane protein 4 (GOLIM4), mRNA.	577	Glu-rich.				transport	Golgi cisterna membrane|Golgi lumen|cis-Golgi network|endocytic vesicle|endosome membrane|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TGCTCTTCATTTTCATCTGGC	0.408000														151			33		0	0	1	0	0
ADORA2A	135	broad.mit.edu	37	22	24837246	24837246	+	Missense_Mutation	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr22:24837246C>T	uc002zzx.3	+	4	1791	c.1028C>T	c.(1027-1029)cCa>cTa	p.P343L	SPECC1L_uc021wne.1_Non-coding_Transcript|ADORA2A_uc002zzy.4_Missense_Mutation_p.P343L|ADORA2A_uc011ajs.2_Missense_Mutation_p.P204L|C22orf45_uc002zzz.2_Intron|ADORA2A_uc010guq.3_Missense_Mutation_p.P343L|ADORA2A_uc010gup.3_Missense_Mutation_p.P343L|ADORA2A_uc003aab.3_Missense_Mutation_p.P343L|C22orf45_uc003aad.1_Intron	NM_000675	NP_000666	P29274	AA2AR_HUMAN	Homo sapiens adenosine A2a receptor (ADORA2A), mRNA.	343					apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(7)|skin(1)	21	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GGCCACCCGCCAGGAGTGTGG	0.662000														48			16		0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182812436	182812436	+	Missense_Mutation	SNP	T	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:182812436T>G	uc001gpr.3	+	2	294	c.119T>G	c.(118-120)gTg>gGg	p.V40G	DHX9_uc001gps.3_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 9 (DHX9), transcript variant 1, mRNA.	40	DRBM 1.|Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	CRD-mediated mRNA stability complex|centrosome|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding	p.V40G(16)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						AAGGTTCAGGTGGAAGGTTAT	0.333000														39			10		0	0	1	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr2:114355998C>G	uc002tkh.3	+	4	674	c.616C>G	c.(616-618)Cac>Gac	p.H206D	WASH2P_uc002tka.3_Non-coding_Transcript|WASH2P_uc002tkd.3_Non-coding_Transcript					Homo sapiens WAS protein family homolog 2 pseudogene (WASH2P), non-coding RNA.																		CCAAGGTGGGCACTTGATGTC	0.612000														24			3		0	0	1	0	0
AK296065	0	broad.mit.edu	37	7	150773354	150773354	+	Missense_Mutation	SNP	C	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr7:150773354C>T	uc011kvf.2	-	0	264	c.91G>A	c.(91-93)Ggt>Agt	p.G31S	SLC4A2_uc022apz.1_Intron|SLC4A2_uc003wit.4_Intron|SLC4A2_uc011kve.2_Intron|SLC4A2_uc003wiu.4_Intron					SubName: Full=cDNA FLJ59028;																		CCTTCTTGACCGCCACCTCCC	0.602000														80			26		0	0	1	0	0
GEN1	348654	broad.mit.edu	37	2	17962008	17962008	+	Missense_Mutation	SNP	G	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr2:17962008G>A	uc002rct.2	+	13	1602	c.1529G>A	c.(1528-1530)gGg>gAg	p.G510E	SMC6_uc010exo.3_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.G510E|GEN1_uc002rcu.2_Missense_Mutation_p.G510E	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Homo sapiens Gen endonuclease homolog 1 (Drosophila) (GEN1), transcript variant 1, mRNA.	510					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(6)|central_nervous_system(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTAAATTCGGGGATTTCCCCT	0.373000								Homologous recombination						73			12		0	0	1	0	0
PUS7	54517	broad.mit.edu	37	7	105099624	105099624	+	Missense_Mutation	SNP	A	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr7:105099624A>G	uc010lji.3	-	14	1866	c.1858T>C	c.(1858-1860)Ttt>Ctt	p.F620L	PUS7_uc003vcx.3_Missense_Mutation_p.F614L|PUS7_uc003vcy.3_Missense_Mutation_p.F614L|PUS7_uc003vcz.1_Missense_Mutation_p.F614L	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	Homo sapiens pseudouridylate synthase 7 homolog (S. cerevisiae) (PUS7), mRNA.	614					pseudouridine synthesis|tRNA processing		RNA binding|pseudouridine synthase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						CCAGAAGCAAAAACTGGTGGT	0.353000														59			14		0	0	1	0	0
ANAPC5	51433	broad.mit.edu	37	12	121766168	121766168	+	Missense_Mutation	SNP	C	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr12:121766168C>A	uc001uag.3	-	9	1377	c.1255G>T	c.(1255-1257)Gat>Tat	p.D419Y	ANAPC5_uc010szu.2_Missense_Mutation_p.D85Y|ANAPC5_uc001uae.3_5'UTR|ANAPC5_uc010szv.2_Missense_Mutation_p.D21Y|ANAPC5_uc001uaf.3_Non-coding_Transcript|ANAPC5_uc001uah.3_Missense_Mutation_p.D307Y	NM_016237	NP_057321	Q9UJX4	APC5_HUMAN	Homo sapiens anaphase promoting complex subunit 5 (ANAPC5), transcript variant 1, mRNA.	419					G2/M transition of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(6)|endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(3)	31	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATGCTGATATCGATGAGCTCT	0.542000														91			18		3.52763e-06	3.73824e-06	1	1	0
FNBP1L	54874	broad.mit.edu	37	1	94009756	94009756	+	Silent	SNP	G	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:94009756G>A	uc010otk.2	+	11	1408	c.1257G>A	c.(1255-1257)caG>caA	p.Q419Q	FNBP1L_uc001dpv.3_Silent_p.Q361Q|FNBP1L_uc001dpw.3_Silent_p.Q361Q|FNBP1L_uc010otl.2_5'UTR	NM_001164473	NP_001157945	Q5T0N5	FBP1L_HUMAN	Homo sapiens formin binding protein 1-like (FNBP1L), transcript variant 3, mRNA.	419	Interaction with CDC42.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|urinary_tract(1)	11		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)		GAGAACTACAGAAAGAATCAG	0.373000														39			15		0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047804	42047804	+	Missense_Mutation	SNP	G	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:42047804G>A	uc001cgz.4	-	3	3878	c.2665C>T	c.(2665-2667)Cgc>Tgc	p.R889C	HIVEP3_uc001cha.4_Missense_Mutation_p.R889C|HIVEP3_uc001cgy.3_Non-coding_Transcript	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	Homo sapiens human immunodeficiency virus type I enhancer binding protein 3 (HIVEP3), transcript variant 1, mRNA.	889	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding	p.R889C(2)		NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GTCTGGCTGCGCTGGGGCCAT	0.597000														207			64		0	0	1	0	0
WASH6P	653440	broad.mit.edu	37	X	155252868	155252868	+	Silent	SNP	T	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chrX:155252868T>A	uc004fnw.1	+	5	1571	c.912T>A	c.(910-912)ccT>ccA	p.P304P	WASH6P_uc022cip.1_Silent_p.P90P	NM_182905	NP_878908			Homo sapiens WAS protein family homolog 1 (WASH1), mRNA.									p.P304P(5)									TAGCCGAGCCTCTCAAGGCAG	0.632000														36			7		0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113741757	113741757	+	Missense_Mutation	SNP	A	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr13:113741757A>G	uc001vsu.3	+	21	2753	c.2753A>G	c.(2752-2754)aAg>aGg	p.K918R	MCF2L_uc001vsq.3_Missense_Mutation_p.K918R|MCF2L_uc010tjr.2_Missense_Mutation_p.K861R|MCF2L_uc001vsr.3_Missense_Mutation_p.K865R|MCF2L_uc001vss.4_Missense_Mutation_p.K859R|MCF2L_uc010tjs.2_Missense_Mutation_p.K859R|MCF2L_uc001vst.1_Missense_Mutation_p.K823R	NM_024979	NP_079255	O15068	MCF2L_HUMAN	Homo sapiens MCF.2 cell line derived transforming sequence-like (MCF2L), transcript variant 2, mRNA.	891	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TACAGCTACAAGCAGTCCTTA	0.592000														36			11		0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19051691	19051691	+	Silent	SNP	C	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr16:19051691C>A	uc002dfp.2	+	8	1390	c.1260C>A	c.(1258-1260)atC>atA	p.I420I	TMC7_uc010vao.1_Missense_Mutation_p.H415N|TMC7_uc002dfq.3_Silent_p.I420I|TMC7_uc010vap.2_Silent_p.I310I	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	Homo sapiens transmembrane channel-like 7 (TMC7), transcript variant 1, mRNA.	420						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						CCAATTTTATCACCCCAATGA	0.418000														137			34		1.36615e-20	1.53962e-20	1	1	0
IGSF10	285313	broad.mit.edu	37	3	151161388	151161388	+	Missense_Mutation	SNP	T	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr3:151161388T>A	uc011bod.2	-	4	5347	c.5347A>T	c.(5347-5349)Aac>Tac	p.N1783Y	IGSF10_uc011bob.2_5'Flank|IGSF10_uc011boc.2_5'Flank	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	Homo sapiens immunoglobulin superfamily, member 10 (IGSF10), transcript variant 1, mRNA.	1783	Ig-like C2-type 4.				cell differentiation|multicellular organismal development|ossification	extracellular region		p.A1782A(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTGTTTGGTTTGCAAGAATC	0.498000														116			38		0	0	1	0	0
CEP95	90799	broad.mit.edu	37	17	62532827	62532827	+	Missense_Mutation	SNP	G	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr17:62532827G>C	uc002jem.3	+	17	2236	c.2178G>C	c.(2176-2178)caG>caC	p.Q726H	CEP95_uc002jen.3_Non-coding_Transcript|CEP95_uc010wqb.2_Missense_Mutation_p.Q562H	NM_138363	NP_612372	Q96GE4	CEP95_HUMAN	Homo sapiens centrosomal protein 95kDa (CEP95), mRNA.	726						centrosome|spindle pole	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)	13						GACGCCACCAGGATGAACTGG	0.458000														97			45		0	0	1	0	0
GLG1	2734	broad.mit.edu	37	16	74640687	74640687	+	Silent	SNP	T	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr16:74640687T>C	uc002fcx.3	-	0	356	c.306A>G	c.(304-306)ggA>ggG	p.G102G	GLG1_uc002fcw.4_Silent_p.G102G|GLG1_uc002fcy.4_Silent_p.G102G|GLG1_uc002fcz.4_5'UTR	NM_012201	NP_036333	Q92896	GSLG1_HUMAN	Homo sapiens golgi glycoprotein 1 (GLG1), transcript variant 1, mRNA.	102						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						CCCCCGCTCCTCCCCGCCGGG	0.697000														24			10		0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27106580	27106580	+	Missense_Mutation	SNP	T	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:27106580T>C	uc001bmv.1	+	19	6564	c.6191T>C	c.(6190-6192)cTc>cCc	p.L2064P	ARID1A_uc001bmu.1_Missense_Mutation_p.L1847P|ARID1A_uc001bmx.1_Missense_Mutation_p.L910P|ARID1A_uc009vsm.1_Missense_Mutation_p.L392P|ARID1A_uc009vsn.1_Missense_Mutation_p.L306P	NM_006015	NP_006006	O14497	ARI1A_HUMAN	Homo sapiens AT rich interactive domain 1A (SWI-like) (ARID1A), transcript variant 1, mRNA.	2064					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TTGGTTACACTCGCCAACATC	0.557000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""									162			54		0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129910454	129910454	+	Missense_Mutation	SNP	T	G	G			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr10:129910454T>G	uc001lke.3	-	8	2107	c.1912A>C	c.(1912-1914)Att>Ctt	p.I638L	MKI67_uc001lkf.3_Missense_Mutation_p.I278L|MKI67_uc009yav.1_Missense_Mutation_p.I213L|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	Homo sapiens antigen identified by monoclonal antibody Ki-67 (MKI67), transcript variant 1, mRNA.	638					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				ATCTGTAAAATATCATGTTGA	0.398000														120			34		0	0	1	0	0
HSPA2	3306	broad.mit.edu	37	14	65009419	65009419	+	Missense_Mutation	SNP	C	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr14:65009419C>A	uc001xhj.3	+	1	1928	c.1852C>A	c.(1852-1854)Cct>Act	p.P618T	HSPA2_uc001xhk.4_Missense_Mutation_p.P618T	NM_021979	NP_068814	P54652	HSP72_HUMAN	Homo sapiens heat shock 70kDa protein 2 (HSPA2), mRNA.	618					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		CCAAGGTGGTCCTggcggcgg	0.552000														67			28		4.59853e-10	4.9469e-10	1	1	0
CEP350	9857	broad.mit.edu	37	1	180047678	180047678	+	Missense_Mutation	SNP	A	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:180047678A>T	uc001gnt.3	+	28	6231	c.5848A>T	c.(5848-5850)Agc>Tgc	p.S1950C	CEP350_uc009wxl.2_Missense_Mutation_p.S1949C|CEP350_uc001gnv.3_Missense_Mutation_p.S85C	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	Homo sapiens centrosomal protein 350kDa (CEP350), mRNA.	1950						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AGAATTAGGCAGCCCTGCTGT	0.433000														39			9		0	0	1	0	0
NDUFAF5	79133	broad.mit.edu	37	20	13775537	13775537	+	Missense_Mutation	SNP	A	T	T			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr20:13775537A>T	uc002wom.3	+	4	472	c.429A>T	c.(427-429)gaA>gaT	p.E143D	NDUFAF5_uc002woo.3_Non-coding_Transcript|NDUFAF5_uc002won.3_Intron	NM_024120	NP_077025	Q5TEU4	CT007_HUMAN	Homo sapiens chromosome 20 open reading frame 7 (C20orf7), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	143					mitochondrial respiratory chain complex I assembly	extrinsic to mitochondrial inner membrane	methyltransferase activity										CTGATGAAGAATTCCTTCCCT	0.318000														33			6		0	0	1	0	0
AARS2	57505	broad.mit.edu	37	6	44272835	44272835	+	Missense_Mutation	SNP	T	A	A			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr6:44272835T>A	uc010jza.1	-	10	1538	c.1535A>T	c.(1534-1536)gAc>gTc	p.D512V	TMEM151B_uc003oxg.3_Intron|TMEM151B_uc003oxf.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (putative) (AARS2), nuclear gene encoding mitochondrial protein, mRNA.	512					alanyl-tRNA aminoacylation	mitochondrion	ATP binding|alanine-tRNA ligase activity|metal ion binding|tRNA binding	p.D511H(1)|p.D512N(1)|p.D511D(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CTTGGGGCTGTCGTCAGTTGG	0.607000											OREG0017473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		312			29		0	0	1	0	0
IPP	3652	broad.mit.edu	37	1	46184897	46184898	+	Frame_Shift_Del	DEL	AC	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr1:46184897_46184898delAC	uc001cou.3	-	5	1430_1431	c.1163_1164delGT	c.(1162-1164)tgtfs	p.C388fs	IPP_uc001cos.4_Frame_Shift_Del_p.C388fs	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	Homo sapiens intracisternal A particle-promoted polypeptide (IPP), transcript variant 1, mRNA.	388						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TAGCCCCATAACACACACACAC	0.347													---	114	---	---	7	---					
SH3BP5	9467	broad.mit.edu	37	3	15373833	15373835	+	In_Frame_Del	DEL	TCC	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr3:15373833_15373835delTCC	uc003bzp.1	-	0	270_272	c.81_83delGGA	c.(79-84)gaggaa>gaa	p.27_28EE>E	SH3BP5_uc003bzq.1_Intron|SH3BP5_uc003bzr.1_Intron	NM_004844	NP_001018009	O60239	3BP5_HUMAN	Homo sapiens SH3-domain binding protein 5 (BTK-associated) (SH3BP5), transcript variant 1, mRNA.	27	Glu-rich.				intracellular signal transduction	mitochondrion	SH3 domain binding|protein kinase inhibitor activity			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						catcccctcttcctcctcctcct	0.719													---	4	---	---	2	---					
MAML3	55534	broad.mit.edu	37	4	140810639	140810641	+	In_Frame_Del	DEL	GCT	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr4:140810639_140810641delGCT	uc021xsg.1	-	1	2701_2703	c.1949_1951delAGC	c.(1948-1953)cagccg>ccg	p.Q650del	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	Homo sapiens mastermind-like 3 (Drosophila) (MAML3), mRNA.	646	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					GGAGGTGGCGgctgctgctgctg	0.586													---	167	---	---	11	---					
FAT1	2195	broad.mit.edu	37	4	187539365	187539365	+	Frame_Shift_Del	DEL	G	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr4:187539365delG	uc003izf.3	-	9	8563	c.8375delC	c.(8374-8376)tctfs	p.S2792fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	Homo sapiens FAT tumor suppressor homolog 1 (Drosophila) (FAT1), mRNA.	2792	Cadherin 25.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AACATCTACAGAAGCCACCAT	0.443										HNSCC(5;0.00058)			---	374	---	---	9	---					
ZNF184	7738	broad.mit.edu	37	6	27420221	27420223	+	In_Frame_Del	DEL	TGG	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr6:27420221_27420223delTGG	uc003njj.3	-	4	1926_1928	c.1115_1117delCCA	c.(1114-1119)accagg>agg	p.T372del	ZNF184_uc010jqv.3_In_Frame_Del_p.T372del|ZNF184_uc003nji.3_In_Frame_Del_p.T372del	NM_007149	NP_009080	Q99676	ZN184_HUMAN	Homo sapiens zinc finger protein 184 (ZNF184), mRNA.	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						TGTGTGCTCCTGGTGAAGGTTTT	0.379													---	84	---	---	20	---					
FOXK1	221937	broad.mit.edu	37	7	4802068	4802068	+	Frame_Shift_Del	DEL	C	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr7:4802068delC	uc003snc.1	+	8	2185	c.2175delC	c.(2173-2175)ggcfs	p.G725fs	FOXK1_uc003sna.1_Frame_Shift_Del_p.G562fs	NM_001037165	NP_001032242	P85037	FOXK1_HUMAN	Homo sapiens forkhead box K1 (FOXK1), mRNA.	725					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		CAGCTGCCGGCCCCCAGGGGC	0.706													---	4	---	---	2	---					
SMARCA2	6595	broad.mit.edu	37	9	2039777	2039779	+	In_Frame_Del	DEL	CAG	-	-	rs113070757	byFrequency	TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr9:2039777_2039779delCAG	uc003zhc.3	+	3	766_768	c.667_669delCAG	c.(667-669)cagdel	p.Q238del	SMARCA2_uc003zhd.3_In_Frame_Del_p.Q238del|SMARCA2_uc010mha.3_In_Frame_Del_p.Q229del	NM_003070	NP_003061	P51531	SMCA2_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2), transcript variant 1, mRNA.	238	Poly-Gln.			Missing (in Ref. 1; CAA51407).	chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	SWI/SNF complex|WINAC complex|intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm	ATP binding|DNA-dependent ATPase activity|RNA polymerase II transcription coactivator activity|helicase activity|protein binding|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		gcagcagcaacagcagcagcagc	0.635													---	68	---	---	7	---					
TSG101	7251	broad.mit.edu	37	11	18541141	18541142	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr11:18541141_18541142delTG	uc001mor.3	-	1	191_192	c.51_52delCA	c.(49-54)tacagafs	p.Y17fs	TSG101_uc001mos.2_Intron|TSG101_uc009yhs.2_Intron	NM_006292	NP_006283	Q99816	TS101_HUMAN	Homo sapiens tumor susceptibility gene 101 (TSG101), mRNA.	17	UEV.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	DNA binding|calcium-dependent protein binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding			kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	22						GTTAGGTCTCTGTATTTGTACT	0.307													---	112	---	---	24	---					
PRB2	653247	broad.mit.edu	37	12	11546506	11546508	+	In_Frame_Del	DEL	TTG	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr12:11546506_11546508delTTG	uc010shk.1	-	2	539_541	c.504_506delCAA	c.(502-507)aacaag>aag	p.N168del		NM_006248	NP_006239			Homo sapiens proline-rich protein BstNI subfamily 2 (PRB2), mRNA.											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			ACTTCGGGACTTGTTGTCTCCTT	0.596													---	1787	---	---	7	---					
LATS2	26524	broad.mit.edu	37	13	21562482	21562483	+	In_Frame_Ins	INS	-	GGGGCG	GGGGCG	rs56252009		TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr13:21562482_21562483insGGGGCG	uc009zzs.3	-	3	1801_1802	c.1436_1437insCGCCCC	c.(1435-1437)ccg>ccCGCCCCg	p.479_479P>PAP	LATS2_uc001unr.4_In_Frame_Ins_p.479_479P>PAP	NM_014572	NP_055387	Q9NRM7	LATS2_HUMAN	Homo sapiens LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2), mRNA.	479					G1/S transition of mitotic cell cycle|cell division|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.P473_A480delPAPAPAPA(3)|p.P479_A480insGR(2)		breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CCTCCGCAgccggggcgggggc	0.787													---	9	---	---	4	---					
SIPA1L1	26037	broad.mit.edu	37	14	72190482	72190484	+	In_Frame_Del	DEL	TCC	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr14:72190482_72190484delTCC	uc001xms.3	+	15	4751_4753	c.4390_4392delTCC	c.(4390-4392)tccdel	p.S1468del	SIPA1L1_uc001xmt.3_In_Frame_Del_p.S1447del|SIPA1L1_uc001xmu.3_In_Frame_Del_p.S1447del|SIPA1L1_uc001xmv.3_In_Frame_Del_p.S1468del|SIPA1L1_uc010ttm.2_In_Frame_Del_p.S922del	NM_015556	NP_056371	O43166	SI1L1_HUMAN	Homo sapiens signal-induced proliferation-associated 1 like 1 (SIPA1L1), mRNA.	1468	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ctcctcctcttcctcctcctcct	0.552													---	306	---	---	9	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	Splice_Site	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	-	rs483929	by1000genomes	TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	uc002hwe.4	-	2	287	c.246_splice	c.e2-1	p.S82_splice		NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	Homo sapiens keratin associated protein 4-1 (KRTAP4-1), mRNA.	101	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].					keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													---	262	---	---	8	---					
MPP3	4356	broad.mit.edu	37	17	41888202	41888203	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr17:41888202_41888203delTT	uc002ieh.3	-	15	1766_1767	c.1505_1506delAA	c.(1504-1506)aaafs	p.K502fs	MPP3_uc002iei.4_Frame_Shift_Del_p.K477fs|MPP3_uc002iej.3_Non-coding_Transcript	NM_001932	NP_001923	Q13368	MPP3_HUMAN	Homo sapiens membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (MPP3), transcript variant 1, mRNA.	477	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		CCAAACAAACTTTGTTTTTGGC	0.450													---	507	---	---	8	---					
HAMP	57817	broad.mit.edu	37	19	35773520	35773522	+	In_Frame_Del	DEL	CTC	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chr19:35773520_35773522delCTC	uc002nyw.3	+	0	111_113	c.40_42delCTC	c.(40-42)ctcdel	p.L18del		NM_021175	NP_066998	P81172	HEPC_HUMAN	Homo sapiens hepcidin antimicrobial peptide (HAMP), mRNA.	18					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGCCTCCTGCTCCTCCTCCTCC	0.640													---	479	---	---	9	---					
GRPR	2925	broad.mit.edu	37	X	16168549	16168550	+	Frame_Shift_Ins	INS	-	C	C			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chrX:16168549_16168550insC	uc004cxj.3	+	1	1188_1189	c.535_536insC	c.(535-537)tctfs	p.S179fs		NM_005314	NP_005305	P30550	GRPR_HUMAN	Homo sapiens gastrin-releasing peptide receptor (GRPR), mRNA.	179					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					GGCCGTGTTTTCTGACCTCCAT	0.505													---	300	---	---	68	---					
CNKSR2	22866	broad.mit.edu	37	X	21627678	21627680	+	In_Frame_Del	DEL	GAG	-	-			TCGA-J7-8537-01A-11D-2396-08	TCGA-J7-8537-10A-01D-2396-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3cf4b130-0aa3-407e-9fea-bd8ddd8b7d5b	56af51d5-45a7-4a64-ba3e-f810d95407f8	g.chrX:21627678_21627680delGAG	uc004czx.2	+	19	3115_3117	c.2635_2637delGAG	c.(2635-2637)gagdel	p.E886del	CNKSR2_uc004czw.3_In_Frame_Del_p.E886del|CNKSR2_uc011mjn.2_In_Frame_Del_p.E837del|CNKSR2_uc011mjo.2_In_Frame_Del_p.E856del|CNKSR2_uc004czy.3_In_Frame_Del_p.E478del	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	Homo sapiens connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 1, mRNA.	886	Poly-Glu.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						ggtggaggaagaggaggaggagg	0.517													---	130	---	---	10	---					
