Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
TMEM51	55092	broad.mit.edu	37	1	15541865	15541865	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:15541865C>T	uc001avw.3	+	3	801	c.282C>T	c.(280-282)GGC>GGT	p.G94G	TMEM51_uc010obk.1_Silent_p.G94G|TMEM51_uc001avz.2_Silent_p.G94G|TMEM51_uc001avy.2_Silent_p.G94G|TMEM51_uc001avx.2_Silent_p.G94G	NM_001136216	NP_001129688	Q9NW97	TMM51_HUMAN	transmembrane protein 51	94						integral to membrane					0		Renal(390;0.00145)|Breast(348;0.00186)|Colorectal(325;0.00215)|all_lung(284;0.00459)|Lung NSC(340;0.0104)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;2.07e-06)|COAD - Colon adenocarcinoma(227;7.14e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000175)|KIRC - Kidney renal clear cell carcinoma(229;0.00141)|STAD - Stomach adenocarcinoma(313;0.00644)|READ - Rectum adenocarcinoma(331;0.0751)		AGCGGCAGGGCGAGGACCTGG	0.652													15	17	---	---	---	---	PASS
UBR4	23352	broad.mit.edu	37	1	19454211	19454211	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:19454211C>T	uc001bbi.2	-	63	9138	c.9134G>A	c.(9133-9135)CGC>CAC	p.R3045H	UBR4_uc001bbk.1_Missense_Mutation_p.R692H	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3045					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAGGGCGCTGCGCTCATTCTT	0.478													6	155	---	---	---	---	PASS
UBR4	23352	broad.mit.edu	37	1	19478225	19478225	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:19478225C>A	uc001bbi.2	-	48	7129	c.7125G>T	c.(7123-7125)ATG>ATT	p.M2375I	UBR4_uc001bbk.1_Missense_Mutation_p.M29I|UBR4_uc001bbl.1_Missense_Mutation_p.M312I|UBR4_uc001bbm.1_Missense_Mutation_p.M1587I	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2375					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GGTTGAGCTGCATAGTTCTGC	0.507													71	113	---	---	---	---	PASS
UBR4	23352	broad.mit.edu	37	1	19478226	19478226	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:19478226A>T	uc001bbi.2	-	48	7128	c.7124T>A	c.(7123-7125)ATG>AAG	p.M2375K	UBR4_uc001bbk.1_Missense_Mutation_p.M29K|UBR4_uc001bbl.1_Missense_Mutation_p.M312K|UBR4_uc001bbm.1_Missense_Mutation_p.M1587K	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	2375					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTTGAGCTGCATAGTTCTGCC	0.507													71	114	---	---	---	---	PASS
KDM1A	23028	broad.mit.edu	37	1	23397826	23397826	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:23397826C>G	uc001bgi.2	+	11	1599	c.1450C>G	c.(1450-1452)CAC>GAC	p.H484D	KDM1A_uc001bgj.2_Missense_Mutation_p.H508D	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	484	Potential.|Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						GAAAAGCAAACACAGGGATCT	0.403													64	120	---	---	---	---	PASS
INADL	10207	broad.mit.edu	37	1	62483535	62483535	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:62483535A>G	uc001dab.2	+	29	3989	c.3875A>G	c.(3874-3876)AAT>AGT	p.N1292S	INADL_uc009waf.1_Missense_Mutation_p.N1292S|INADL_uc001daa.2_Missense_Mutation_p.N1292S|INADL_uc001dad.3_Missense_Mutation_p.N989S|INADL_uc001dac.2_RNA|INADL_uc010oot.1_Missense_Mutation_p.N76S|INADL_uc009wag.2_Missense_Mutation_p.N76S|INADL_uc010oou.1_Intron	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1292	PDZ 7.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CAGATAAACAATCAGATTCTG	0.333													64	103	---	---	---	---	PASS
LRRC7	57554	broad.mit.edu	37	1	70225900	70225900	+	Missense_Mutation	SNP	C	T	T	rs150507629		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:70225900C>T	uc001dep.2	+	1	43	c.13C>T	c.(13-15)CGG>TGG	p.R5W	LRRC7_uc001deo.1_Missense_Mutation_p.R43W|LRRC7_uc009wbg.2_Translation_Start_Site	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	5						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GACCACCAAACGGAAAATCAT	0.438													9	63	---	---	---	---	PASS
SFRS11	9295	broad.mit.edu	37	1	70716350	70716350	+	Silent	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:70716350A>G	uc001des.2	+	13	1441	c.1317A>G	c.(1315-1317)AAA>AAG	p.K439K	SFRS11_uc001det.2_Silent_p.K438K|SFRS11_uc001dev.2_Silent_p.K249K|SFRS11_uc001dew.2_Silent_p.K379K	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	439					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						AAGAGAAAAAAGAAGAGAAGA	0.393													21	49	---	---	---	---	PASS
ZNF644	84146	broad.mit.edu	37	1	91405548	91405548	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:91405548G>A	uc001dnw.2	-	3	1505	c.1363C>T	c.(1363-1365)CGG>TGG	p.R455W	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.R455W	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	455	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		CGAAATGTCCGTCCACATTCT	0.403													10	231	---	---	---	---	PASS
ARHGAP29	9411	broad.mit.edu	37	1	94685819	94685819	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:94685819A>G	uc001dqj.3	-	3	704	c.335T>C	c.(334-336)GTG>GCG	p.V112A	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.V112A	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	112					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CTTACCTTTCACTTTTGCAGT	0.368													107	152	---	---	---	---	PASS
COL11A1	1301	broad.mit.edu	37	1	103474062	103474062	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:103474062C>A	uc001dul.2	-	15	1958	c.1640G>T	c.(1639-1641)GGT>GTT	p.G547V	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.G559V|COL11A1_uc001dun.2_Missense_Mutation_p.G508V|COL11A1_uc009weh.2_Missense_Mutation_p.G431V	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	547	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCCAGATGAACCAGGCCCCCC	0.299													58	56	---	---	---	---	PASS
RSBN1	54665	broad.mit.edu	37	1	114354481	114354481	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:114354481T>C	uc001edq.2	-	1	590	c.554A>G	c.(553-555)CAT>CGT	p.H185R	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	185	His-rich.					nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTGGCCCTTATGCTTGGGCCC	0.682													19	26	---	---	---	---	PASS
IGSF3	3321	broad.mit.edu	37	1	117150571	117150571	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:117150571G>T	uc001egr.1	-	5	1920	c.1215C>A	c.(1213-1215)CTC>CTA	p.L405L	IGSF3_uc001egq.1_Silent_p.L405L|IGSF3_uc001egs.1_Silent_p.L78L	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	405	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		TACTGAGGGGGAGGACTATGA	0.517													15	192	---	---	---	---	PASS
HORMAD1	84072	broad.mit.edu	37	1	150680777	150680777	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:150680777G>T	uc001evk.1	-	9	608	c.502C>A	c.(502-504)CCT>ACT	p.P168T	HORMAD1_uc001evl.1_Missense_Mutation_p.P161T|HORMAD1_uc001evm.1_Missense_Mutation_p.P88T	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	168	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			ACATCATTAGGTAAAGGCCCC	0.353													8	103	---	---	---	---	PASS
SEMA6C	10500	broad.mit.edu	37	1	151109537	151109537	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:151109537C>A	uc001ewu.2	-	11	1070	c.770G>T	c.(769-771)CGC>CTC	p.R257L	SEMA6C_uc001ewv.2_Missense_Mutation_p.R257L|SEMA6C_uc001eww.2_Missense_Mutation_p.R217L|SEMA6C_uc010pcq.1_Missense_Mutation_p.R257L|SEMA6C_uc009wml.1_RNA	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	257	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCGGGCTACGCGGGAGAACTG	0.582													31	103	---	---	---	---	PASS
HSD17B7	51478	broad.mit.edu	37	1	162774108	162774108	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:162774108G>A	uc001gci.2	+	7	894	c.799G>A	c.(799-801)GCT>ACT	p.A267T	HSD17B7_uc009wuv.2_RNA	NM_016371	NP_057455	P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	267	Cytoplasmic (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			ovary(1)	1	all_hematologic(112;0.115)				NADH(DB00157)	TGGAACAGAAGCTCTGGTATG	0.333													36	60	---	---	---	---	PASS
DUSP27	92235	broad.mit.edu	37	1	167097199	167097199	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:167097199C>A	uc001geb.1	+	5	2831	c.2831C>A	c.(2830-2832)ACG>AAG	p.T944K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	944	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GGCCTCAGGACGGAGGAAAAA	0.507													9	36	---	---	---	---	PASS
C1orf25	81627	broad.mit.edu	37	1	185125643	185125643	+	Missense_Mutation	SNP	A	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:185125643A>C	uc001grf.3	-	1	474	c.202T>G	c.(202-204)TCC>GCC	p.S68A	C1orf26_uc001grg.3_5'Flank|C1orf26_uc001grh.3_5'Flank|C1orf25_uc010pon.1_Intron	NM_030934	NP_112196	Q7Z2T5	TRM1L_HUMAN	N2,N2-dimethylguanosine tRNA	68						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding				0						gaggctagggacggggacagg	0.219													24	23	---	---	---	---	PASS
C1orf26	54823	broad.mit.edu	37	1	185153960	185153960	+	Silent	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:185153960C>G	uc001grg.3	+	9	1440	c.1326C>G	c.(1324-1326)GCC>GCG	p.A442A	C1orf26_uc001grh.3_Silent_p.A442A	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	442	PINc.										0						TAAAACGTGCCCAGCACAAAG	0.378													71	84	---	---	---	---	PASS
NAV1	89796	broad.mit.edu	37	1	201752839	201752839	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:201752839T>A	uc001gwu.2	+	7	3010	c.2663T>A	c.(2662-2664)CTC>CAC	p.L888H	NAV1_uc001gwv.1_Missense_Mutation_p.L396H|NAV1_uc001gww.1_Missense_Mutation_p.L497H|NAV1_uc001gwx.2_Missense_Mutation_p.L497H|NAV1_uc001gwy.1_Missense_Mutation_p.L269H	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	888					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						ATGGAGTCCCTCCAGATGCCA	0.602													26	90	---	---	---	---	PASS
CR2	1380	broad.mit.edu	37	1	207646387	207646387	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:207646387C>T	uc001hfw.2	+	10	1935	c.1841C>T	c.(1840-1842)TCT>TTT	p.S614F	CR2_uc001hfv.2_Missense_Mutation_p.S614F|CR2_uc009xch.2_Missense_Mutation_p.S614F|CR2_uc009xci.1_Missense_Mutation_p.S99F	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	614	Sushi 10.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TACAAGATATCTGGCAAGGAA	0.453													34	108	---	---	---	---	PASS
LIN9	286826	broad.mit.edu	37	1	226475435	226475435	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:226475435G>A	uc001hqa.2	-	5	686	c.376C>T	c.(376-378)CGT>TGT	p.R126C	LIN9_uc001hqb.2_Missense_Mutation_p.R91C|LIN9_uc001hqc.2_Missense_Mutation_p.R58C|LIN9_uc009xel.1_Missense_Mutation_p.R91C	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	110	Sufficient for interaction with RB1.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		AGCAGATTACGTAATCGAAAA	0.303													99	123	---	---	---	---	PASS
OBSCN	84033	broad.mit.edu	37	1	228495859	228495859	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:228495859G>A	uc009xez.1	+	47	12558	c.12514G>A	c.(12514-12516)GCC>ACC	p.A4172T	OBSCN_uc001hsn.2_Missense_Mutation_p.A4172T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4172	Ig-like 43.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGAGGTGACGGCCGATGAGGA	0.597													20	64	---	---	---	---	PASS
NLRP3	114548	broad.mit.edu	37	1	247588143	247588143	+	Silent	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:247588143C>A	uc001icr.2	+	5	1536	c.1398C>A	c.(1396-1398)CTC>CTA	p.L466L	NLRP3_uc001ics.2_Silent_p.L466L|NLRP3_uc001icu.2_Silent_p.L466L|NLRP3_uc001icw.2_Silent_p.L466L|NLRP3_uc001icv.2_Silent_p.L466L|NLRP3_uc010pyw.1_Silent_p.L464L|NLRP3_uc001ict.1_Silent_p.L464L	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	466	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCGCCCACCTCTGGGGGCTCT	0.592													11	37	---	---	---	---	PASS
OR2T10	127069	broad.mit.edu	37	1	248756875	248756875	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr1:248756875C>G	uc010pzn.1	-	1	195	c.195G>C	c.(193-195)CAG>CAC	p.Q65H		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGAGTGAGAGCTGGTTTATAA	0.428													33	46	---	---	---	---	PASS
SH3YL1	26751	broad.mit.edu	37	2	229996	229996	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:229996C>A	uc002qvx.2	-	8	835	c.751G>T	c.(751-753)GCA>TCA	p.A251S	SH3YL1_uc002qvy.2_Missense_Mutation_p.A251S|SH3YL1_uc002qvz.2_RNA|SH3YL1_uc002qwa.2_RNA|SH3YL1_uc010ewe.2_Missense_Mutation_p.A155S|SH3YL1_uc002qvu.2_RNA|SH3YL1_uc002qvv.2_Missense_Mutation_p.A155S|SH3YL1_uc002qvw.2_RNA	NM_015677	NP_056492	Q96HL8	SH3Y1_HUMAN	SH3 domain containing, Ysc84-like 1 isoform 1	251										ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.034)		all cancers(51;0.000647)|Epithelial(75;0.0043)|OV - Ovarian serous cystadenocarcinoma(76;0.00871)|GBM - Glioblastoma multiforme(21;0.148)		TGGACTGGTGCAGATGACTGC	0.313													41	61	---	---	---	---	PASS
KIDINS220	57498	broad.mit.edu	37	2	8938353	8938353	+	Silent	SNP	A	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:8938353A>C	uc002qzc.2	-	10	1160	c.978T>G	c.(976-978)CCT>CCG	p.P326P	KIDINS220_uc010yiv.1_Silent_p.P92P|KIDINS220_uc002qzd.2_Silent_p.P284P|KIDINS220_uc010yiw.1_Silent_p.P327P	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	326	Cytoplasmic (Potential).|ANK 10.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTTCAGTGTCAGGATTGCACT	0.343													45	75	---	---	---	---	PASS
GCKR	2646	broad.mit.edu	37	2	27720154	27720154	+	Missense_Mutation	SNP	A	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:27720154A>C	uc002rky.2	+	2	170	c.104A>C	c.(103-105)AAC>ACC	p.N35T	FNDC4_uc002rkx.2_5'Flank|GCKR_uc010ezd.2_Missense_Mutation_p.N35T|GCKR_uc010ylu.1_5'UTR	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	35					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					GAGAAGTCAAACCCACTGACC	0.537													8	174	---	---	---	---	PASS
SPDYA	245711	broad.mit.edu	37	2	29045243	29045243	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:29045243G>T	uc002rmj.2	+	5	553	c.347G>T	c.(346-348)AGT>ATT	p.S116I	SPDYA_uc002rmi.2_Missense_Mutation_p.S116I|SPDYA_uc002rmk.2_Missense_Mutation_p.S116I|SPDYA_uc002rml.2_Missense_Mutation_p.S116I	NM_182756	NP_877433	Q5MJ70	SPDYA_HUMAN	speedy homolog A isoform 1	116	Speedy/Ringo box; Required for CDK- binding (By similarity).				G1/S transition of mitotic cell cycle|multicellular organismal development|positive regulation of cell proliferation|response to DNA damage stimulus	nucleus	protein kinase binding			upper_aerodigestive_tract(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TTTACTATAAGTGAGCATACC	0.254													25	34	---	---	---	---	PASS
EML4	27436	broad.mit.edu	37	2	42472648	42472648	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:42472648A>G	uc002rsi.2	+	2	291	c.29A>G	c.(28-30)GAT>GGT	p.D10G	EML4_uc002rsh.3_Missense_Mutation_p.D10G|EML4_uc010fap.2_Missense_Mutation_p.D10G	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	10					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						TTTATAGATGATAGTATTTCT	0.338			T	ALK	NSCLC								19	18	---	---	---	---	PASS
FBXO11	80204	broad.mit.edu	37	2	48035532	48035532	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:48035532T>C	uc010fbl.2	-	22	2452	c.2338A>G	c.(2338-2340)ATA>GTA	p.I780V	FBXO11_uc002rwe.2_Missense_Mutation_p.I780V|FBXO11_uc010fbk.2_Missense_Mutation_p.I288V	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	864	UBR-type.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding	p.I780V(1)		ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTCACACATATGGCATTTCGA	0.338													77	145	---	---	---	---	PASS
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48873991	48873991	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:48873991T>A	uc010yol.1	+	5	2806	c.2759T>A	c.(2758-2760)GTG>GAG	p.V920E	STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.V967E|GTF2A1L_uc002rws.1_Missense_Mutation_p.V263E|GTF2A1L_uc010yom.1_Missense_Mutation_p.V229E|GTF2A1L_uc002rwt.2_Missense_Mutation_p.V263E	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	920					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GTGGAGTCAGTGCTCAGTGGT	0.463													62	96	---	---	---	---	PASS
CCDC85A	114800	broad.mit.edu	37	2	56420458	56420458	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:56420458G>A	uc002rzn.2	+	2	1625	c.1123G>A	c.(1123-1125)GGA>AGA	p.G375R		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	375										breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TCACAAACACGGAGGAGGCAG	0.642													15	19	---	---	---	---	PASS
CTNNA2	1496	broad.mit.edu	37	2	80096990	80096990	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:80096990C>A	uc010ysh.1	+	4	519	c.514C>A	c.(514-516)CTT>ATT	p.L172I	CTNNA2_uc010yse.1_Missense_Mutation_p.L172I|CTNNA2_uc010ysf.1_Missense_Mutation_p.L172I|CTNNA2_uc010ysg.1_Missense_Mutation_p.L172I	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	172					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TGAGCAAGACCTTGCAAACCG	0.378													70	115	---	---	---	---	PASS
LRRTM1	347730	broad.mit.edu	37	2	80529586	80529586	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:80529586G>A	uc002sok.1	-	2	1629	c.1359C>T	c.(1357-1359)TTC>TTT	p.F453F	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	453	Cytoplasmic (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GGCTGGCTGGGAAACACTTCC	0.577										HNSCC(69;0.2)			5	50	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89309488	89309488	+	RNA	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:89309488A>G	uc010ytr.1	-	74		c.6859T>C			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GAGGGTAACTATTAAGCTGTT	0.507													96	158	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	90121978	90121978	+	RNA	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:90121978C>A	uc010fhm.2	+	16		c.1847C>A								Parts of antibodies, mostly variable regions.																		AGGGAAAGTCCCTAAGCACCT	0.507													112	203	---	---	---	---	PASS
AFF3	3899	broad.mit.edu	37	2	100182031	100182031	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:100182031C>T	uc002tag.2	-	19	3273	c.3037G>A	c.(3037-3039)GAG>AAG	p.E1013K	AFF3_uc002taf.2_Missense_Mutation_p.E1038K	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1013					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TTTCCACACTCGATAAACGAC	0.398													98	148	---	---	---	---	PASS
YSK4	80122	broad.mit.edu	37	2	135779388	135779388	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:135779388T>C	uc002tue.1	-	2	66	c.35A>G	c.(34-36)GAG>GGG	p.E12G	YSK4_uc010fne.1_5'UTR|YSK4_uc002tuf.1_Missense_Mutation_p.E12G|YSK4_uc010fnc.1_Missense_Mutation_p.E12G|YSK4_uc010fnd.1_Missense_Mutation_p.E12G|YSK4_uc010zbg.1_Missense_Mutation_p.E12G|YSK4_uc002tui.3_Missense_Mutation_p.E29G	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	12							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		AAGCAATGACTCAGCATGTCT	0.333													40	126	---	---	---	---	PASS
BAZ2B	29994	broad.mit.edu	37	2	160303316	160303316	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:160303316T>C	uc002uao.2	-	6	1025	c.673A>G	c.(673-675)AGA>GGA	p.R225G	BAZ2B_uc002uap.2_Missense_Mutation_p.R223G|BAZ2B_uc002uas.1_Missense_Mutation_p.R162G|BAZ2B_uc002uau.1_Missense_Mutation_p.R223G|BAZ2B_uc002uaq.1_Missense_Mutation_p.R153G|BAZ2B_uc002uat.3_Missense_Mutation_p.R162G|BAZ2B_uc010fop.1_Missense_Mutation_p.R223G	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	225	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTGTCAACTCTAGCATCCAAA	0.358													127	205	---	---	---	---	PASS
PDK1	5163	broad.mit.edu	37	2	173427012	173427012	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:173427012A>G	uc002uhr.2	+	3	503	c.403A>G	c.(403-405)ATT>GTT	p.I135V	PDK1_uc010zdz.1_5'UTR|PDK1_uc010zea.1_RNA|PDK1_uc002uhq.1_Missense_Mutation_p.I135V|PDK1_uc002uhs.2_Missense_Mutation_p.I135V|PDK1_uc010zeb.1_Missense_Mutation_p.I135V	NM_002610	NP_002601	Q15118	PDK1_HUMAN	pyruvate dehydrogenase kinase 1 precursor	135					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|small GTPase mediated signal transduction	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(3)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.12)			TGCTAAAGCTATTTATGAGTA	0.333									Autosomal_Dominant_Polycystic_Kidney_Disease				98	172	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179584771	179584771	+	Silent	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:179584771A>G	uc010zfg.1	-	78	20090	c.19866T>C	c.(19864-19866)TAT>TAC	p.Y6622Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Silent_p.Y3283Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7549							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTGGCATATATATTTTCCAG	0.398													22	70	---	---	---	---	PASS
ITGAV	3685	broad.mit.edu	37	2	187500923	187500923	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:187500923A>G	uc002upq.2	+	7	1022	c.746A>G	c.(745-747)GAC>GGC	p.D249G	ITGAV_uc010frs.2_Missense_Mutation_p.D213G|ITGAV_uc010zfv.1_Missense_Mutation_p.D203G	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	249	FG-GAP 4.|Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		ATTTTTGATGACAGCTATTTG	0.328													30	184	---	---	---	---	PASS
SF3B1	23451	broad.mit.edu	37	2	198281577	198281577	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:198281577T>C	uc002uue.2	-	6	602	c.554A>G	c.(553-555)AAT>AGT	p.N185S	SF3B1_uc010fsk.1_RNA	NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	185					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGCTGCTCCATTGACGACTTT	0.433													174	234	---	---	---	---	PASS
SPATS2L	26010	broad.mit.edu	37	2	201283977	201283977	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:201283977A>G	uc002uvn.3	+	6	555	c.203A>G	c.(202-204)AAT>AGT	p.N68S	SPATS2L_uc010fst.2_Missense_Mutation_p.N68S|SPATS2L_uc002uvo.3_Missense_Mutation_p.N8S|SPATS2L_uc002uvp.3_Missense_Mutation_p.N68S|SPATS2L_uc002uvq.3_Missense_Mutation_p.N68S|SPATS2L_uc002uvr.3_Missense_Mutation_p.N68S|SPATS2L_uc010zhc.1_Missense_Mutation_p.N98S	NM_015535	NP_056350	Q9NUQ6	SPS2L_HUMAN	SPATS2-like protein isoform a	68						cytoplasm|nucleolus				ovary(2)|pancreas(1)	3						TTCTAGAACAATAAAAGAAAA	0.403													4	5	---	---	---	---	PASS
INO80D	54891	broad.mit.edu	37	2	206921016	206921016	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:206921016G>A	uc002vaz.3	-	4	1275	c.870C>T	c.(868-870)TTC>TTT	p.F290F		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	290					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						AGTGTGGAGAGAAGGCTGTGG	0.537													29	85	---	---	---	---	PASS
ABCB6	10058	broad.mit.edu	37	2	220078648	220078648	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr2:220078648G>A	uc002vkc.1	-	9	1755	c.1478C>T	c.(1477-1479)TCA>TTA	p.S493L	ABCB6_uc010fwe.1_Missense_Mutation_p.S447L	NM_005689	NP_005680	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B, member 6	493	ABC transmembrane type-1.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAAAACCAGTGAAGCGCTCGA	0.542													94	119	---	---	---	---	PASS
TIMP4	7079	broad.mit.edu	37	3	12195884	12195884	+	Silent	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:12195884C>A	uc003bwo.2	-	4	727	c.420G>T	c.(418-420)CTG>CTT	p.L140L	SYN2_uc003bwl.1_Intron|SYN2_uc003bwm.2_Intron|SYN2_uc003bwn.2_Intron	NM_003256	NP_003247	Q99727	TIMP4_HUMAN	tissue inhibitor of metalloproteinase 4	140	NTR.						metal ion binding|metalloendopeptidase inhibitor activity				0						GCACCAAGGACAGGTCCTCCC	0.502													92	53	---	---	---	---	PASS
KCNH8	131096	broad.mit.edu	37	3	19436804	19436804	+	Splice_Site	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:19436804G>A	uc003cbk.1	+	7	1372	c.1177_splice	c.e7+1	p.G393_splice	KCNH8_uc011awe.1_Splice_Site_p.G393_splice|KCNH8_uc010hex.1_Splice_Site|KCNH8_uc011awf.1_Splice_Site_p.G24_splice	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,							integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TGGGAAGTTGGTAAGGGCTTA	0.363													54	41	---	---	---	---	PASS
LARS2	23395	broad.mit.edu	37	3	45588957	45588957	+	Nonsense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:45588957C>T	uc003cop.1	+	22	2832	c.2647C>T	c.(2647-2649)CGA>TGA	p.R883*	LARS2_uc010hit.1_Nonsense_Mutation_p.R840*	NM_015340	NP_056155	Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	883					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	TTTGCAAGGACGAAGCATCAA	0.537													6	161	---	---	---	---	PASS
ATXN7	6314	broad.mit.edu	37	3	63981634	63981634	+	Silent	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:63981634A>G	uc003dlw.3	+	12	2689	c.2136A>G	c.(2134-2136)CCA>CCG	p.P712P	ATXN7_uc003dlv.2_Silent_p.P712P|ATXN7_uc010hnv.2_Silent_p.P712P|ATXN7_uc011bfn.1_Silent_p.P567P	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	712	Ser-rich.				cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		ACAGTTCCCCACTGTTGGTTC	0.403													36	20	---	---	---	---	PASS
LRIG1	26018	broad.mit.edu	37	3	66436511	66436511	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:66436511G>T	uc003dmx.2	-	13	1697	c.1683C>A	c.(1681-1683)ATC>ATA	p.I561I	SLC25A26_uc011bft.1_Intron|LRIG1_uc011bfu.1_Silent_p.I181I|LRIG1_uc003dmw.2_Silent_p.I227I|LRIG1_uc010hnz.2_Silent_p.I277I|LRIG1_uc010hoa.2_Silent_p.I585I	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	561	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GGAGGTGCAGGATGGTGGTGT	0.552													104	56	---	---	---	---	PASS
FILIP1L	11259	broad.mit.edu	37	3	99649618	99649618	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:99649618G>T	uc003dtm.2	-	2	710	c.247C>A	c.(247-249)CTG>ATG	p.L83M	C3orf26_uc003dtk.1_Intron|C3orf26_uc003dtl.2_Intron|FILIP1L_uc003dto.2_Missense_Mutation_p.L83M|uc003dtq.2_5'Flank	NM_182909	NP_878913	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like isoform 1	83						cytoplasm|membrane|myosin complex|nucleus				ovary(1)	1						CTGACCTGCAGTTCTCCCTCC	0.493													10	39	---	---	---	---	PASS
STAG1	10274	broad.mit.edu	37	3	136076678	136076678	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:136076678C>T	uc003era.1	-	28	3241	c.2949G>A	c.(2947-2949)GAG>GAA	p.E983E	STAG1_uc003erb.1_Silent_p.E983E	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	983					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						TAAATGCAAACTCTATGCCAT	0.323													44	53	---	---	---	---	PASS
SMC4	10051	broad.mit.edu	37	3	160118637	160118637	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:160118637C>T	uc003fdh.2	+	2	136	c.23C>T	c.(22-24)CCC>CTC	p.P8L	IFT80_uc003fda.2_Intron|IFT80_uc011boy.1_5'Flank|IFT80_uc003fdd.1_5'Flank|IFT80_uc003fde.1_5'Flank|SMC4_uc003fdf.1_RNA|SMC4_uc003fdg.1_Missense_Mutation_p.P8L|SMC4_uc010hwc.1_5'UTR|SMC4_uc003fdi.2_Missense_Mutation_p.P8L|SMC4_uc003fdj.2_Missense_Mutation_p.P8L|SMC4_uc010hwd.2_Missense_Mutation_p.P8L	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	8					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGCACCCAGCCCTCCACTGCC	0.771													4	15	---	---	---	---	PASS
ZBBX	79740	broad.mit.edu	37	3	166960360	166960360	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:166960360T>C	uc003fep.2	-	20	2532	c.2209A>G	c.(2209-2211)AGT>GGT	p.S737G	ZBBX_uc011bpc.1_Missense_Mutation_p.S776G|ZBBX_uc003feq.2_Missense_Mutation_p.S708G	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	737						intracellular	zinc ion binding			ovary(2)	2						GAAATCTGACTTATATTCAGT	0.368													144	70	---	---	---	---	PASS
GHSR	2693	broad.mit.edu	37	3	172166129	172166129	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:172166129G>A	uc003fib.1	-	1	75	c.75C>T	c.(73-75)CCC>CCT	p.P25P	GHSR_uc011bpv.1_Silent_p.P25P	NM_198407	NP_940799	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor isoform 1a	25	Extracellular (Potential).				actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			lung(3)|ovary(1)|central_nervous_system(1)	5	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			AGTCGTTGCCGGGGGAAGCAT	0.682													17	53	---	---	---	---	PASS
EPHB3	2049	broad.mit.edu	37	3	184297317	184297317	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr3:184297317T>A	uc003foz.2	+	10	2291	c.1854T>A	c.(1852-1854)AAT>AAA	p.N618K		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	618	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			AGGACCCTAATGAGGCTGTTC	0.552													32	235	---	---	---	---	PASS
EPHA5	2044	broad.mit.edu	37	4	66189926	66189926	+	Missense_Mutation	SNP	C	A	A	rs145811811		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr4:66189926C>A	uc003hcy.2	-	18	3213	c.3020G>T	c.(3019-3021)CGG>CTG	p.R1007L	EPHA5_uc003hcx.2_Missense_Mutation_p.R939L|EPHA5_uc003hcz.2_Missense_Mutation_p.R985L|EPHA5_uc011cah.1_Missense_Mutation_p.R1008L|EPHA5_uc011cai.1_Missense_Mutation_p.R986L	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	1007	Cytoplasmic (Potential).|SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity	p.R1007Q(1)		lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CACTCCAAGCCGTCTCAAATC	0.433										TSP Lung(17;0.13)			44	47	---	---	---	---	PASS
GRID2	2895	broad.mit.edu	37	4	94436493	94436493	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr4:94436493G>C	uc011cdt.1	+	13	2382	c.2124G>C	c.(2122-2124)ATG>ATC	p.M708I	GRID2_uc011cdu.1_Missense_Mutation_p.M613I	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	708	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTCCCAAATGTGGCGGATGA	0.473													34	27	---	---	---	---	PASS
CFI	3426	broad.mit.edu	37	4	110662170	110662170	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr4:110662170A>G	uc003hzr.3	-	13	1839	c.1631T>C	c.(1630-1632)GTG>GCG	p.V544A	CFI_uc003hzq.2_Missense_Mutation_p.V341A|CFI_uc011cft.1_Missense_Mutation_p.V552A|CFI_uc003hzs.3_Missense_Mutation_p.V537A	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	544	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		CCCCCAACTCACAACACCCCA	0.463													17	433	---	---	---	---	PASS
BBS12	166379	broad.mit.edu	37	4	123665027	123665027	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr4:123665027G>T	uc003ieu.2	+	2	2173	c.1980G>T	c.(1978-1980)CCG>CCT	p.P660P		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	660					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						AGCAGATTCCGAGAGTTTATG	0.368									Bardet-Biedl_syndrome				3	101	---	---	---	---	PASS
FAT4	79633	broad.mit.edu	37	4	126240503	126240503	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr4:126240503T>A	uc003ifj.3	+	1	2937	c.2937T>A	c.(2935-2937)AGT>AGA	p.S979R		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	979	Cadherin 9.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCTCCTCTAGTGTCATCTTAA	0.448													78	66	---	---	---	---	PASS
LARP1B	55132	broad.mit.edu	37	4	129012165	129012165	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr4:129012165G>T	uc003iga.2	+	6	499	c.368G>T	c.(367-369)CGA>CTA	p.R123L	LARP1B_uc003ifw.1_Missense_Mutation_p.R76L|LARP1B_uc003ifx.2_Missense_Mutation_p.R123L|LARP1B_uc003ify.2_Missense_Mutation_p.R123L|LARP1B_uc003ifz.1_Missense_Mutation_p.R123L	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	123	Arg-rich.						RNA binding				0						GGTTGGAAGCGAGATAGAGAA	0.373													3	85	---	---	---	---	PASS
NEIL3	55247	broad.mit.edu	37	4	178272630	178272630	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr4:178272630C>T	uc003iut.2	+	7	1083	c.966C>T	c.(964-966)ACC>ACT	p.T322T	NEIL3_uc010irs.2_Intron	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	322	RanBP2-type.				base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		AGCACTGGACCTGTGTGGTGT	0.438								BER_DNA_glycosylases					118	100	---	---	---	---	PASS
CTNND2	1501	broad.mit.edu	37	5	11346612	11346612	+	Silent	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr5:11346612C>A	uc003jfa.1	-	9	1645	c.1500G>T	c.(1498-1500)GCG>GCT	p.A500A	CTNND2_uc010itt.2_Silent_p.A409A|CTNND2_uc011cmy.1_Silent_p.A163A|CTNND2_uc011cmz.1_Silent_p.A67A|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.A67A	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	500					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGTAGGGGTCCGCGTAATTGG	0.657													177	113	---	---	---	---	PASS
CDH10	1008	broad.mit.edu	37	5	24535250	24535250	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr5:24535250A>T	uc003jgr.1	-	5	1117	c.785T>A	c.(784-786)GTC>GAC	p.V262D	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	262	Cadherin 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GTTGTCATTGACATCTGTCAG	0.448										HNSCC(23;0.051)			10	250	---	---	---	---	PASS
TIMD4	91937	broad.mit.edu	37	5	156390197	156390197	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr5:156390197G>T	uc003lwh.2	-	1	70	c.13C>A	c.(13-15)CCT>ACT	p.P5T	TIMD4_uc010jii.2_Missense_Mutation_p.P5T	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	5						integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAATGAGAGGTTCTTTGGAC	0.453													62	27	---	---	---	---	PASS
CYFIP2	26999	broad.mit.edu	37	5	156787368	156787368	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr5:156787368T>A	uc003lwq.2	+	27	3034	c.2896T>A	c.(2896-2898)TAT>AAT	p.Y966N	CYFIP2_uc011ddn.1_Missense_Mutation_p.Y940N|CYFIP2_uc011ddo.1_Missense_Mutation_p.Y770N|CYFIP2_uc003lwr.2_Missense_Mutation_p.Y966N|CYFIP2_uc003lws.2_Missense_Mutation_p.Y966N|CYFIP2_uc003lwt.2_Missense_Mutation_p.Y869N|CYFIP2_uc011ddp.1_Missense_Mutation_p.Y700N	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	991					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCGACATGAGTATGGCTCCCC	0.502													54	51	---	---	---	---	PASS
GABRG2	2566	broad.mit.edu	37	5	161580117	161580117	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr5:161580117C>G	uc003lyz.3	+	9	1505	c.1147C>G	c.(1147-1149)CGC>GGC	p.R383G	GABRG2_uc010jjc.2_Missense_Mutation_p.R431G|GABRG2_uc003lyy.3_Missense_Mutation_p.R391G|GABRG2_uc011dej.1_Missense_Mutation_p.R288G	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	383	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CATTGATATCCGCCCAAGATC	0.493													53	43	---	---	---	---	PASS
SH3PXD2B	285590	broad.mit.edu	37	5	171766540	171766540	+	Silent	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr5:171766540A>T	uc003mbr.2	-	13	1740	c.1569T>A	c.(1567-1569)CCT>CCA	p.P523P		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	523					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTTTCCGCGGAGGGAGGCTGG	0.632													60	23	---	---	---	---	PASS
NUP153	9972	broad.mit.edu	37	6	17675990	17675990	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:17675990T>C	uc003ncd.1	-	3	546	c.346A>G	c.(346-348)ACT>GCT	p.T116A	NUP153_uc011dje.1_Missense_Mutation_p.T116A|NUP153_uc010jpl.1_Missense_Mutation_p.T116A	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	116					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			GCAGTACTAGTTGTTGAAGGT	0.348													54	98	---	---	---	---	PASS
ID4	3400	broad.mit.edu	37	6	19838206	19838206	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:19838206G>T	uc003ncw.2	+	1	590	c.221G>T	c.(220-222)CGC>CTC	p.R74L		NM_001546	NP_001537	P47928	ID4_HUMAN	inhibitor of DNA binding 4, dominant negative	74	Helix-loop-helix motif.						transcription corepressor activity				0	Ovarian(93;0.0355)|Breast(50;0.0654)|all_epithelial(95;0.12)		OV - Ovarian serous cystadenocarcinoma(7;0.00659)|all cancers(50;0.0327)|Epithelial(50;0.0621)			TGCTATAGCCGCCTGCGGAGG	0.562													6	3	---	---	---	---	PASS
BTN1A1	696	broad.mit.edu	37	6	26505264	26505264	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:26505264C>A	uc003nif.3	+	3	559	c.539C>A	c.(538-540)TCC>TAC	p.S180Y		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	180	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						TGGAGAACTTCCAAGGGAGAG	0.498													48	94	---	---	---	---	PASS
OR12D3	81797	broad.mit.edu	37	6	29342373	29342373	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:29342373C>A	uc003nme.2	-	1	696	c.692G>T	c.(691-693)AGA>ATA	p.R231I		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						GTGGAGTATTCTGCAGGACCT	0.463													63	71	---	---	---	---	PASS
OR10C1	442194	broad.mit.edu	37	6	29408069	29408069	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:29408069C>T	uc011dlp.1	+	1	277	c.277C>T	c.(277-279)CGC>TGC	p.R93C	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCACATCTCTCGCTCTGGATG	0.592													63	107	---	---	---	---	PASS
TNXB	7148	broad.mit.edu	37	6	32018015	32018015	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:32018015T>A	uc003nzl.2	-	27	9395	c.9193A>T	c.(9193-9195)ACC>TCC	p.T3065S		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3112	Fibronectin type-III 23.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTGTCACGGTCAGCTCCCCC	0.622													34	75	---	---	---	---	PASS
HLA-DPA1	3113	broad.mit.edu	37	6	33041344	33041344	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:33041344G>A	uc003ocs.1	-	1	35	c.4C>T	c.(4-6)CGC>TGC	p.R2C	HLA-DPA1_uc010juk.2_Missense_Mutation_p.R2C|HLA-DPA1_uc003oct.1_Missense_Mutation_p.R2C|HLA-DPB1_uc011dqn.1_5'Flank|HLA-DPB1_uc003ocu.1_5'Flank|HLA-DPB1_uc011dqo.1_5'Flank|HLA-DPB1_uc011dqp.1_5'Flank	NM_033554	NP_291032	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP	2					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			skin(1)	1						TCTTCAGGGCGCATGTTGTGG	0.532													5	192	---	---	---	---	PASS
COL11A2	1302	broad.mit.edu	37	6	33137206	33137206	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:33137206G>A	uc003ocx.1	-	51	3980	c.3752C>T	c.(3751-3753)CCA>CTA	p.P1251L	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Missense_Mutation_p.P1165L|COL11A2_uc003ocz.1_Missense_Mutation_p.P1144L	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1251	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TTTAGGCCCTGGTGGCCCTGG	0.637													28	41	---	---	---	---	PASS
TAPBP	6892	broad.mit.edu	37	6	33272137	33272137	+	Nonsense_Mutation	SNP	G	A	A	rs79026906		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:33272137G>A	uc003odx.1	-	5	1318	c.1147C>T	c.(1147-1149)CGA>TGA	p.R383*	TAPBP_uc010jus.1_Nonsense_Mutation_p.R401*|TAPBP_uc003ody.2_3'UTR|TAPBP_uc003odz.2_Nonsense_Mutation_p.R383*|TAPBP_uc010jut.1_Nonsense_Mutation_p.R296*|TAPBP_uc011drc.1_Nonsense_Mutation_p.R383*	NM_003190	NP_003181	O15533	TPSN_HUMAN	tapasin isoform 1 precursor	383	Ig-like C1-type.|Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			ovary(1)	1						TGGTGAATTCGACAGGCATAG	0.652													8	84	---	---	---	---	PASS
DNAH8	1769	broad.mit.edu	37	6	38830121	38830121	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:38830121G>A	uc003ooe.1	+	42	6146	c.5546G>A	c.(5545-5547)GGC>GAC	p.G1849D		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGACCTGCTGGCACTGGCAAA	0.463													62	129	---	---	---	---	PASS
TCTE1	202500	broad.mit.edu	37	6	44249916	44249916	+	Silent	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:44249916G>C	uc003oxi.2	-	4	1383	c.1227C>G	c.(1225-1227)CTC>CTG	p.L409L	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	409	LRR 4.									ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCTGTGACAGGAGTGTGGCGG	0.602													22	30	---	---	---	---	PASS
ENPP4	22875	broad.mit.edu	37	6	46107441	46107441	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:46107441C>T	uc003oxy.2	+	2	380	c.121C>T	c.(121-123)CTG>TTG	p.L41L		NM_014936	NP_055751	Q9Y6X5	ENPP4_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	41	Extracellular (Potential).					integral to membrane	hydrolase activity			ovary(3)|skin(1)	4						AGCTGATTATCTGAAGAACTA	0.338													9	235	---	---	---	---	PASS
UBE2CBP	90025	broad.mit.edu	37	6	83748153	83748153	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:83748153C>T	uc003pjp.2	-	5	757	c.649G>A	c.(649-651)GGA>AGA	p.G217R	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjr.2_Missense_Mutation_p.G185R	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	217						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		ACGGTCTCTCCCAACATTACC	0.328													61	112	---	---	---	---	PASS
FIG4	9896	broad.mit.edu	37	6	110056478	110056478	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:110056478G>T	uc003ptt.2	+	6	838	c.623G>T	c.(622-624)GGA>GTA	p.G208V	FIG4_uc011eau.1_Missense_Mutation_p.G62V	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	208	SAC.				cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GAAGATGAAGGATTAATTACA	0.368													83	155	---	---	---	---	PASS
C6orf204	387119	broad.mit.edu	37	6	118801596	118801596	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:118801596T>C	uc003pxz.1	-	9	2414	c.1826A>G	c.(1825-1827)AAT>AGT	p.N609S		NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	609	Potential.					centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		GAGATTATCATTTTCATTCTG	0.343													76	121	---	---	---	---	PASS
TXLNB	167838	broad.mit.edu	37	6	139583798	139583798	+	Missense_Mutation	SNP	C	T	T	rs147752054	by1000genomes	TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:139583798C>T	uc011eds.1	-	5	965	c.800G>A	c.(799-801)CGA>CAA	p.R267Q		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	267	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		CTTCATATTTCGCTCACTCTG	0.498													87	123	---	---	---	---	PASS
GRM1	2911	broad.mit.edu	37	6	146720537	146720537	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:146720537G>C	uc010khw.1	+	8	2832	c.2362G>C	c.(2362-2364)GCG>CCG	p.A788P	GRM1_uc010khv.1_Missense_Mutation_p.A788P|GRM1_uc003qll.2_Missense_Mutation_p.A788P|GRM1_uc011edz.1_Missense_Mutation_p.A788P|GRM1_uc011eea.1_Missense_Mutation_p.A788P	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	788	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CAAATATATCGCGTTCACCAT	0.493													64	117	---	---	---	---	PASS
PLEKHG1	57480	broad.mit.edu	37	6	151161857	151161857	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:151161857G>A	uc003qny.1	+	17	4295	c.3983G>A	c.(3982-3984)CGC>CAC	p.R1328H	PLEKHG1_uc011eem.1_Missense_Mutation_p.R1387H	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1328					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		AATAGTCCGCGCACTCCAAAA	0.428													13	179	---	---	---	---	PASS
IGF2R	3482	broad.mit.edu	37	6	160525909	160525909	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:160525909G>T	uc003qta.2	+	48	7417	c.7269G>T	c.(7267-7269)TCG>TCT	p.S2423S		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2423	Cytoplasmic (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AAGTTCACTCGGGCAGGGGAG	0.587													49	97	---	---	---	---	PASS
DNAH11	8701	broad.mit.edu	37	7	21646301	21646301	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:21646301T>A	uc003svc.2	+	20	3833	c.3802T>A	c.(3802-3804)TAT>AAT	p.Y1268N		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1268	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ATTCAGACACTATGCCCCTCT	0.333									Kartagener_syndrome				18	33	---	---	---	---	PASS
DNAH11	8701	broad.mit.edu	37	7	21730458	21730458	+	Silent	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:21730458T>A	uc003svc.2	+	36	6052	c.6021T>A	c.(6019-6021)GCT>GCA	p.A2007A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2007	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CGGGTTATGCTGGTCGAACCG	0.408									Kartagener_syndrome				123	240	---	---	---	---	PASS
DNAH11	8701	broad.mit.edu	37	7	21757534	21757534	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:21757534C>A	uc003svc.2	+	44	7177	c.7146C>A	c.(7144-7146)AGC>AGA	p.S2382R		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2382					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTGAGAGTAGCCTGGTGCAGG	0.403									Kartagener_syndrome				69	165	---	---	---	---	PASS
ELMO1	9844	broad.mit.edu	37	7	37298804	37298804	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:37298804A>G	uc003tfk.1	-	6	702	c.395T>C	c.(394-396)ATG>ACG	p.M132T	ELMO1_uc011kbc.1_Missense_Mutation_p.M36T|ELMO1_uc010kxg.1_Missense_Mutation_p.M132T	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	132					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GCTCTCCACCATCTGCGTGAG	0.522													18	53	---	---	---	---	PASS
HECW1	23072	broad.mit.edu	37	7	43496007	43496007	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:43496007G>C	uc003tid.1	+	13	3217	c.2612G>C	c.(2611-2613)AGA>ACA	p.R871T	HECW1_uc011kbi.1_Missense_Mutation_p.R837T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	871	Potential.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GGCATGCGGAGATCGGGGTCC	0.582													11	44	---	---	---	---	PASS
GRM3	2913	broad.mit.edu	37	7	86416271	86416271	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:86416271C>A	uc003uid.2	+	3	2262	c.1163C>A	c.(1162-1164)TCC>TAC	p.S388Y	GRM3_uc010lef.2_Missense_Mutation_p.S386Y|GRM3_uc010leg.2_Missense_Mutation_p.S260Y|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	388	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GAGCAAGAGTCCAAGATCATG	0.542													29	137	---	---	---	---	PASS
CDK14	5218	broad.mit.edu	37	7	90419918	90419918	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:90419918G>A	uc003uky.2	+	5	717	c.495G>A	c.(493-495)GTG>GTA	p.V165V	CDK14_uc003ukt.1_Silent_p.V119V|CDK14_uc003ukv.1_Silent_p.V119V|CDK14_uc003uku.1_Silent_p.V119V|CDK14_uc003ukx.1_RNA|CDK14_uc003ukz.1_Silent_p.V147V|CDK14_uc010les.1_Silent_p.V119V|CDK14_uc011khl.1_Silent_p.V36V	NM_012395	NP_036527	O94921	CDK14_HUMAN	PFTAIRE protein kinase 1	165	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			lung(3)|ovary(1)	4						CTCTGAAGGTGATCAGGCTGC	0.403													43	73	---	---	---	---	PASS
FZD1	8321	broad.mit.edu	37	7	90895353	90895353	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:90895353C>T	uc003ula.2	+	1	1571	c.1158C>T	c.(1156-1158)GCC>GCT	p.A386A		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	386	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			ACAAGTTCGCCGAGGACGGGG	0.602													59	107	---	---	---	---	PASS
SLC13A1	6561	broad.mit.edu	37	7	122765635	122765635	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:122765635T>C	uc003vkm.2	-	11	1253	c.1228A>G	c.(1228-1230)ACA>GCA	p.T410A	SLC13A1_uc010lks.2_Missense_Mutation_p.T286A	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	410						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	ATTTCTCCTGTAGGTGTAGTT	0.368													87	143	---	---	---	---	PASS
FLNC	2318	broad.mit.edu	37	7	128492892	128492892	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:128492892C>T	uc003vnz.3	+	37	6224	c.6015C>T	c.(6013-6015)TTC>TTT	p.F2005F	FLNC_uc003voa.3_Silent_p.F1972F	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2005	Filamin 18.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GGATCTCCTTCACCCCCAAGG	0.632													49	68	---	---	---	---	PASS
CNOT4	4850	broad.mit.edu	37	7	135048771	135048771	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr7:135048771C>A	uc011kpy.1	-	10	1767	c.1675G>T	c.(1675-1677)GGG>TGG	p.G559W	CNOT4_uc003vss.2_Intron|CNOT4_uc011kpz.1_Missense_Mutation_p.G556W|CNOT4_uc003vst.2_Intron	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCCCTTAGCCCGTCCTGCCAT	0.428													70	208	---	---	---	---	PASS
CSMD1	64478	broad.mit.edu	37	8	3855524	3855524	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:3855524G>A	uc011kwk.1	-	5	1109	c.719C>T	c.(718-720)GCT>GTT	p.A240V		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	240	Extracellular (Potential).|CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCGGGCTCAGCCAGAATGGT	0.562													7	7	---	---	---	---	PASS
KCTD9	54793	broad.mit.edu	37	8	25296837	25296837	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:25296837G>A	uc003xeo.2	-	6	615	c.457C>T	c.(457-459)CGT>TGT	p.R153C	PPP2R2A_uc003xek.2_Intron	NM_017634	NP_060104	Q7L273	KCTD9_HUMAN	potassium channel tetramerisation domain	153	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		all_cancers(63;0.0164)|Ovarian(32;0.000878)|all_epithelial(46;0.00542)|Breast(100;0.0164)|Hepatocellular(4;0.114)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Epithelial(17;2.39e-12)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0438)		TGTCCATGACGCAAGTAGTTC	0.353													7	67	---	---	---	---	PASS
GSR	2936	broad.mit.edu	37	8	30567337	30567337	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:30567337T>C	uc003xih.1	-	3	507	c.416A>G	c.(415-417)AAT>AGT	p.N139S		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	139					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TTACCGCCAATTGAATTTACC	0.368													47	21	---	---	---	---	PASS
TRAM1	23471	broad.mit.edu	37	8	71506818	71506818	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:71506818T>C	uc003xyo.1	-	6	663	c.493A>G	c.(493-495)ATG>GTG	p.M165V	TRAM1_uc011lfc.1_Missense_Mutation_p.M134V	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	165	Helical; (Potential).|TLC.				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			AAAAACTTCATTTGAAATCTG	0.308													52	106	---	---	---	---	PASS
FABP5	2171	broad.mit.edu	37	8	82195650	82195650	+	Silent	SNP	T	C	C	rs143988575		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:82195650T>C	uc003yca.1	+	2	177	c.129T>C	c.(127-129)TGT>TGC	p.C43C		NM_001444	NP_001435	Q01469	FABP5_HUMAN	fatty acid binding protein 5	43					epidermis development	cytoplasm	fatty acid binding|protein binding|transporter activity				0	Lung NSC(7;3.57e-05)|all_lung(9;0.00011)		Epithelial(68;0.102)			AGCCAGATTGTATCATCACTT	0.388													58	55	---	---	---	---	PASS
DCAF4L2	138009	broad.mit.edu	37	8	88885116	88885116	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:88885116C>A	uc003ydz.2	-	1	1181	c.1084G>T	c.(1084-1086)GAC>TAC	p.D362Y		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	362										ovary(1)	1						CTGGGAATGTCGTTCTCCGAG	0.627													9	172	---	---	---	---	PASS
KCNS2	3788	broad.mit.edu	37	8	99440386	99440386	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:99440386A>G	uc003yin.2	+	2	529	c.179A>G	c.(178-180)GAT>GGT	p.D60G		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	60	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GAGCTCTGCGATGACTACGAC	0.627													25	165	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139180147	139180147	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:139180147G>A	uc003yuy.2	-	12	1420	c.1249C>T	c.(1249-1251)CCT>TCT	p.P417S	FAM135B_uc003yux.2_Missense_Mutation_p.P318S|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	417										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCTGTCGCAGGGCAGTCCACG	0.507										HNSCC(54;0.14)			68	238	---	---	---	---	PASS
CYP11B1	1584	broad.mit.edu	37	8	143956549	143956549	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr8:143956549A>G	uc003yxi.2	-	8	1229	c.1222T>C	c.(1222-1224)TAC>CAC	p.Y408H	CYP11B1_uc010mex.2_Missense_Mutation_p.Y107H|CYP11B1_uc003yxh.2_Intron|CYP11B1_uc003yxj.2_Intron|CYP11B1_uc010mey.2_Missense_Mutation_p.Y479H	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	408					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CCCAGAGAGTAGAGGAACACG	0.632									Familial_Hyperaldosteronism_type_I				98	83	---	---	---	---	PASS
GRHPR	9380	broad.mit.edu	37	9	37424897	37424897	+	Nonsense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr9:37424897C>T	uc003zzu.1	+	2	180	c.139C>T	c.(139-141)CGA>TGA	p.R47*	GRHPR_uc010mlu.2_5'UTR|GRHPR_uc010mlv.1_5'UTR|GRHPR_uc003zzt.1_5'UTR	NM_012203	NP_036335	Q9UBQ7	GRHPR_HUMAN	glyoxylate reductase/hydroxypyruvate reductase	47					cellular nitrogen compound metabolic process|excretion|glyoxylate metabolic process	peroxisomal matrix	glycerate dehydrogenase activity|glyoxylate reductase (NADP) activity|hydroxypyruvate reductase activity|NAD binding|protein binding				0				GBM - Glioblastoma multiforme(29;0.00687)		GGAGCTAGAGCGAGGTGTGGC	0.667													16	26	---	---	---	---	PASS
C9orf135	138255	broad.mit.edu	37	9	72459523	72459523	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr9:72459523G>T	uc004ahl.2	+	2	308	c.243G>T	c.(241-243)CTG>CTT	p.L81L	C9orf135_uc011lrw.1_Intron|C9orf135_uc010moq.2_Intron|C9orf135_uc011lrx.1_Intron|C9orf135_uc010mop.2_Silent_p.L81L	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	81	Extracellular (Potential).					integral to membrane				ovary(1)	1						ATCGGCGACTGGGAACCGATG	0.388													5	89	---	---	---	---	PASS
SLC27A4	10999	broad.mit.edu	37	9	131110861	131110861	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr9:131110861C>T	uc004but.2	+	4	878	c.594C>T	c.(592-594)CTC>CTT	p.L198L	SLC27A4_uc004buu.2_Intron	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid	198					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding				0						ACCCCTCGCTCAGCCTCTTCT	0.627													50	35	---	---	---	---	PASS
POMT1	10585	broad.mit.edu	37	9	134393912	134393912	+	Silent	SNP	C	T	T	rs144385159	byFrequency	TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr9:134393912C>T	uc004cav.2	+	14	1621	c.1419C>T	c.(1417-1419)TCC>TCT	p.S473S	POMT1_uc004cax.2_Silent_p.S451S|POMT1_uc011mcj.1_Silent_p.S229S|POMT1_uc004cau.2_Silent_p.S451S|POMT1_uc004caw.2_Silent_p.S397S|POMT1_uc011mck.1_Silent_p.S334S|POMT1_uc011mcl.1_Silent_p.S299S|POMT1_uc011mcm.1_Silent_p.S421S|POMT1_uc011mcn.1_Silent_p.S176S	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	473	MIR 3.				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TGAACACTTCCGCTGTCTTAA	0.537													183	107	---	---	---	---	PASS
CACNA1B	774	broad.mit.edu	37	9	140880881	140880881	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr9:140880881C>T	uc004cog.2	+	14	1931	c.1786C>T	c.(1786-1788)CGG>TGG	p.R596W	CACNA1B_uc011mfd.1_Missense_Mutation_p.R127W	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	596	Cytoplasmic (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GAGCTCCCTGCGGAACCTGGT	0.587													3	25	---	---	---	---	PASS
FRMD4A	55691	broad.mit.edu	37	10	13900908	13900908	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr10:13900908G>A	uc001ims.2	-	3	402	c.50C>T	c.(49-51)ACG>ATG	p.T17M	FRMD4A_uc009xjf.1_Missense_Mutation_p.T17M|FRMD4A_uc001imt.1_Missense_Mutation_p.T50M|FRMD4A_uc001imu.1_Missense_Mutation_p.T33M	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	17						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GCGGCCCTCCGTCATCTAAGA	0.498													9	147	---	---	---	---	PASS
MLLT10	8028	broad.mit.edu	37	10	21959404	21959404	+	Silent	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr10:21959404T>A	uc001iqs.2	+	10	1170	c.822T>A	c.(820-822)TCT>TCA	p.S274S	MLLT10_uc001iqt.2_Silent_p.S274S|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Silent_p.S274S|MLLT10_uc001ira.2_5'UTR|MLLT10_uc001iqz.2_Silent_p.S29S	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	274	Self-association.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						GCAACAACTCTATATCTGGAT	0.368			T	MLL|PICALM|CDK6	AL								33	23	---	---	---	---	PASS
SLC18A2	6571	broad.mit.edu	37	10	119013587	119013587	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr10:119013587C>T	uc001ldd.1	+	5	583	c.552C>T	c.(550-552)TTC>TTT	p.F184F	SLC18A2_uc009xyy.1_5'UTR	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	184	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	GCTATGCCTTCCTGCTGATTG	0.602													146	76	---	---	---	---	PASS
MUC6	4588	broad.mit.edu	37	11	1016826	1016826	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:1016826G>T	uc001lsw.2	-	31	6026	c.5975C>A	c.(5974-5976)ACC>AAC	p.T1992N		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1992	Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATAGGTAGTGGTGGTCTGGAA	0.552													19	676	---	---	---	---	PASS
OR51A4	401666	broad.mit.edu	37	11	4967668	4967668	+	Silent	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:4967668C>G	uc010qys.1	-	1	663	c.663G>C	c.(661-663)CTG>CTC	p.L221L		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTTGAGGATCAGGGTGTAAG	0.428													45	101	---	---	---	---	PASS
OR56A4	120793	broad.mit.edu	37	11	6023374	6023374	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:6023374G>T	uc010qzv.1	-	1	1005	c.1005C>A	c.(1003-1005)CAC>CAA	p.H335Q		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	283	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAATGAGGTGGTGCAGGATGT	0.493													38	55	---	---	---	---	PASS
OR6A2	8590	broad.mit.edu	37	11	6816012	6816012	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:6816012G>C	uc001mes.1	-	1	1128	c.928C>G	c.(928-930)CTG>GTG	p.L310V		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TACAGGTGCAGAGTACAGCAT	0.448													56	92	---	---	---	---	PASS
OR10A4	283297	broad.mit.edu	37	11	6898608	6898608	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:6898608G>A	uc010rat.1	+	1	730	c.730G>A	c.(730-732)GCC>ACC	p.A244T		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CACCTGTTCCGCCCACCTCTT	0.527													82	115	---	---	---	---	PASS
AMPD3	272	broad.mit.edu	37	11	10503750	10503750	+	Silent	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:10503750A>G	uc001mio.1	+	4	902	c.567A>G	c.(565-567)GCA>GCG	p.A189A	AMPD3_uc010rbz.1_Silent_p.A30A|AMPD3_uc001min.1_Silent_p.A198A|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Silent_p.A189A|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Silent_p.A196A|AMPD3_uc009yfy.2_Silent_p.A189A	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	189					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CGGATACTGCACCTCCGGAAG	0.622													43	73	---	---	---	---	PASS
INSC	387755	broad.mit.edu	37	11	15247263	15247263	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:15247263G>A	uc001mly.2	+	9	1246	c.1200G>A	c.(1198-1200)ACG>ACA	p.T400T	INSC_uc001mlz.2_Silent_p.T353T|INSC_uc001mma.2_Silent_p.T353T|INSC_uc010rcs.1_Silent_p.T388T|INSC_uc001mmb.2_Silent_p.T353T|INSC_uc001mmc.2_Silent_p.T311T	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	400					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CCAACATCACGTTCTTTGACA	0.512													24	31	---	---	---	---	PASS
WT1	7490	broad.mit.edu	37	11	32421532	32421532	+	Missense_Mutation	SNP	A	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:32421532A>C	uc001mtn.1	-	6	1256	c.1060T>G	c.(1060-1062)TAC>GAC	p.Y354D	WT1_uc001mtl.1_Missense_Mutation_p.Y142D|WT1_uc001mtm.1_Missense_Mutation_p.Y125D|WT1_uc001mto.1_Missense_Mutation_p.Y354D|WT1_uc001mtp.1_Missense_Mutation_p.Y337D|WT1_uc001mtq.1_Missense_Mutation_p.Y337D|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	286					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			TGTATTCTGTATTGGGCTCCG	0.577			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				50	86	---	---	---	---	PASS
PEX16	9409	broad.mit.edu	37	11	45935463	45935463	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:45935463C>A	uc001nbu.2	-	9	1106	c.794G>T	c.(793-795)GGC>GTC	p.G265V	PEX16_uc001nbt.2_Missense_Mutation_p.G265V	NM_004813	NP_004804	Q9Y5Y5	PEX16_HUMAN	peroxisomal biogenesis factor 16 isoform 1	265	Interaction with PEX19.|Cytoplasmic (Potential).				ER-dependent peroxisome organization|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein import into peroxisome membrane	endoplasmic reticulum membrane|integral to peroxisomal membrane	protein C-terminus binding			ovary(2)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.223)		CCGGGTCAGGCCCTTTCTGTC	0.652													10	15	---	---	---	---	PASS
OR8H1	219469	broad.mit.edu	37	11	56058339	56058339	+	Nonsense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:56058339G>T	uc010rje.1	-	1	200	c.200C>A	c.(199-201)TCA>TAA	p.S67*		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	67	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					GTCAATAAATGACAAGTGAGT	0.418													223	391	---	---	---	---	PASS
USP28	57646	broad.mit.edu	37	11	113675696	113675696	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:113675696G>A	uc001poh.2	-	20	2506	c.2473C>T	c.(2473-2475)CTT>TTT	p.L825F	USP28_uc001pog.2_Missense_Mutation_p.L501F|USP28_uc010rwy.1_Missense_Mutation_p.L668F|USP28_uc001poi.2_Missense_Mutation_p.L148F	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	825					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		ACATGCTGAAGTCGAGGATCA	0.433													53	88	---	---	---	---	PASS
OR8D2	283160	broad.mit.edu	37	11	124189986	124189986	+	Silent	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:124189986C>G	uc010sah.1	-	1	108	c.108G>C	c.(106-108)GTG>GTC	p.V36V		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		CCACTGTGACCACATATATTC	0.453													49	120	---	---	---	---	PASS
ARHGAP32	9743	broad.mit.edu	37	11	128843255	128843255	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:128843255G>A	uc009zcp.2	-	21	3104	c.3104C>T	c.(3103-3105)CCT>CTT	p.P1035L	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Missense_Mutation_p.P686L	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1035	Poly-Pro.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						ATTTTTCGGAGGCGGTGGTGG	0.527													121	157	---	---	---	---	PASS
SLC2A3	6515	broad.mit.edu	37	12	8077098	8077098	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:8077098C>T	uc001qtr.2	-	8	1238	c.976G>A	c.(976-978)GTG>ATG	p.V326M		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	326	Cytoplasmic (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		GCCCTTTCCACCAGAAATAGC	0.433													27	114	---	---	---	---	PASS
KLRC1	3821	broad.mit.edu	37	12	10601872	10601872	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:10601872G>A	uc001qyl.2	-	5	617	c.453C>T	c.(451-453)AAC>AAT	p.N151N	KLRC1_uc009zhm.1_Silent_p.N151N|KLRC1_uc001qym.2_Silent_p.N133N|KLRC1_uc001qyn.2_Silent_p.N151N|KLRC1_uc001qyo.2_Silent_p.N133N	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	151	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						GCAGACTGGAGTTCTTCGAAG	0.303													154	246	---	---	---	---	PASS
ST8SIA1	6489	broad.mit.edu	37	12	22487151	22487151	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:22487151G>T	uc001rfo.3	-	1	498	c.16C>A	c.(16-18)CGG>AGG	p.R6R	ST8SIA1_uc009zix.2_5'UTR|uc001rfp.1_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	6	Cytoplasmic (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						CGCCGGGCCCGCCCGCAGGGG	0.731													26	45	---	---	---	---	PASS
CAPRIN2	65981	broad.mit.edu	37	12	30888129	30888129	+	Silent	SNP	C	G	G	rs145888176		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:30888129C>G	uc001rji.1	-	4	1333	c.582G>C	c.(580-582)GCG>GCC	p.A194A	CAPRIN2_uc001rjf.1_5'UTR|CAPRIN2_uc001rjg.1_5'UTR|CAPRIN2_uc001rjh.1_Silent_p.A194A|CAPRIN2_uc001rjj.1_5'UTR|CAPRIN2_uc001rjk.3_Silent_p.A194A|CAPRIN2_uc001rjl.3_Silent_p.A194A	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	194	Potential.				negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CCTTCTTTTGCGCTTTTAGTA	0.378													78	171	---	---	---	---	PASS
PPHLN1	51535	broad.mit.edu	37	12	42792791	42792791	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:42792791G>A	uc001rng.1	+	9	1009	c.904G>A	c.(904-906)GAA>AAA	p.E302K	PPHLN1_uc001rmy.2_Missense_Mutation_p.E320K|PPHLN1_uc001rna.2_Missense_Mutation_p.E254K|PPHLN1_uc001rne.2_Missense_Mutation_p.E290K|PPHLN1_uc001rnb.2_Missense_Mutation_p.E309K|PPHLN1_uc001rnd.2_Missense_Mutation_p.E254K|PPHLN1_uc001rnc.2_Missense_Mutation_p.E302K|PPHLN1_uc001rnf.2_Missense_Mutation_p.E283K|PPHLN1_uc010skq.1_Missense_Mutation_p.E228K|PPHLN1_uc010skr.1_Missense_Mutation_p.E247K|PPHLN1_uc010sks.1_Missense_Mutation_p.E228K|PPHLN1_uc010skt.1_Missense_Mutation_p.E182K|PPHLN1_uc001rni.1_Missense_Mutation_p.E247K|PPHLN1_uc001rnh.1_RNA|PPHLN1_uc010sku.1_Missense_Mutation_p.E235K|PPHLN1_uc001rnj.2_Missense_Mutation_p.E118K	NM_016488	NP_057572	Q8NEY8	PPHLN_HUMAN	periphilin 1 isoform 1	302					keratinization	cytoplasm|nucleus				ovary(1)|breast(1)	2	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		CAAAGAGATTGAACAGGTGAG	0.343													61	98	---	---	---	---	PASS
ZDHHC17	23390	broad.mit.edu	37	12	77216233	77216233	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:77216233G>T	uc001syk.1	+	8	982	c.819G>T	c.(817-819)ATG>ATT	p.M273I	ZDHHC17_uc001syi.1_RNA|ZDHHC17_uc001syj.2_RNA	NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	273	Cytoplasmic (Potential).				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						ATGTGTGGATGATCAACCACT	0.368													17	43	---	---	---	---	PASS
MYF6	4618	broad.mit.edu	37	12	81101662	81101662	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:81101662A>T	uc001szf.1	+	1	217	c.164A>T	c.(163-165)GAC>GTC	p.D55V		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	55					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						GCGGGGAGCGACAGCAGCGGA	0.617													41	57	---	---	---	---	PASS
TMEM119	338773	broad.mit.edu	37	12	108985855	108985855	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:108985855C>A	uc001tng.2	-	2	468	c.305G>T	c.(304-306)GGC>GTC	p.G102V	TMEM119_uc001tnf.2_RNA	NM_181724	NP_859075	Q4V9L6	TM119_HUMAN	transmembrane protein 119 precursor	102	Helical; (Potential).					integral to membrane				ovary(1)	1						GGCCAGGGAGCCCACCACAGC	0.602													36	54	---	---	---	---	PASS
FBXW8	26259	broad.mit.edu	37	12	117402577	117402577	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:117402577C>T	uc001twg.1	+	5	835	c.753C>T	c.(751-753)GAC>GAT	p.D251D	FBXW8_uc001twf.1_Silent_p.D185D|FBXW8_uc009zwp.1_RNA	NM_153348	NP_699179	Q8N3Y1	FBXW8_HUMAN	F-box and WD repeat domain containing 8 isoform	251							protein binding			ovary(2)|pancreas(1)	3	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0353)		AATCAGAGGACGAGGAGGATG	0.517													93	220	---	---	---	---	PASS
CDK2AP1	8099	broad.mit.edu	37	12	123751808	123751808	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr12:123751808G>A	uc001ueq.2	-	2	599	c.77C>T	c.(76-78)TCC>TTC	p.S26F	CDK2AP1_uc001uep.2_RNA	NM_004642	NP_004633	O14519	CDKA1_HUMAN	CDK2-associated protein  1	26					DNA-dependent DNA replication|protein phosphorylation|S phase of mitotic cell cycle	cytoplasm|nucleus	DNA binding|protein binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000554)|Epithelial(86;0.00178)		CATGCTGGTGGAAGGCGAGTG	0.612													38	66	---	---	---	---	PASS
CLYBL	171425	broad.mit.edu	37	13	100518606	100518606	+	Silent	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr13:100518606A>T	uc001vok.2	+	6	761	c.747A>T	c.(745-747)CGA>CGT	p.R249R	CLYBL_uc010tix.1_3'UTR|CLYBL_uc010tiy.1_Silent_p.R215R	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	249					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTGACTTTCGAGATGGAGCTG	0.468													43	30	---	---	---	---	PASS
OR4Q3	441669	broad.mit.edu	37	14	20216294	20216294	+	Missense_Mutation	SNP	G	T	T	rs138111427		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr14:20216294G>T	uc010tkt.1	+	1	708	c.708G>T	c.(706-708)AAG>AAT	p.K236N		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GCCAGAACAAGGTCTTCTCTA	0.483													56	404	---	---	---	---	PASS
MYH7	4625	broad.mit.edu	37	14	23895275	23895275	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr14:23895275G>T	uc001wjx.2	-	19	2166	c.2060C>A	c.(2059-2061)CCC>CAC	p.P687H		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	687	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGACCAGGGGGTTGTCCAT	0.448													22	45	---	---	---	---	PASS
CTSG	1511	broad.mit.edu	37	14	25043635	25043635	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr14:25043635C>T	uc001wpq.2	-	4	447	c.410G>A	c.(409-411)AGA>AAA	p.R137K		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	137	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		CGTCCCGGGTCTCAGTCCCTC	0.607													69	106	---	---	---	---	PASS
ZC3H14	79882	broad.mit.edu	37	14	89037457	89037457	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr14:89037457C>G	uc001xww.2	+	4	449	c.224C>G	c.(223-225)TCT>TGT	p.S75C	ZC3H14_uc010twd.1_Missense_Mutation_p.S75C|ZC3H14_uc010twe.1_Missense_Mutation_p.S75C|ZC3H14_uc001xwx.2_Missense_Mutation_p.S75C|ZC3H14_uc010twf.1_5'UTR|ZC3H14_uc001xwy.2_Missense_Mutation_p.S41C|ZC3H14_uc010twg.1_5'Flank	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	75						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						AAACTTCGCTCTGTTACAACT	0.308													51	48	---	---	---	---	PASS
KIAA1409	57578	broad.mit.edu	37	14	94088544	94088544	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr14:94088544C>T	uc001ybv.1	+	28	4583	c.4500C>T	c.(4498-4500)GGC>GGT	p.G1500G	KIAA1409_uc001ybs.1_Silent_p.G1478G	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1655						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TGAACCAAGGCGATGACGGCC	0.552													21	62	---	---	---	---	PASS
SERPINA1	5265	broad.mit.edu	37	14	94845910	94845910	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr14:94845910C>A	uc001ycx.3	-	4	1217	c.956G>T	c.(955-957)GGA>GTA	p.G319V	SERPINA1_uc001ycw.3_RNA|SERPINA1_uc010auw.2_Missense_Mutation_p.G319V|SERPINA1_uc010aux.2_Missense_Mutation_p.G319V|SERPINA1_uc001ycy.3_Missense_Mutation_p.G319V|SERPINA1_uc010auy.2_Missense_Mutation_p.G319V|SERPINA1_uc001ycz.3_Missense_Mutation_p.G319V|SERPINA1_uc010auz.2_Missense_Mutation_p.G319V|SERPINA1_uc010ava.2_Missense_Mutation_p.G319V|SERPINA1_uc001ydb.3_Missense_Mutation_p.G319V|SERPINA1_uc010avb.2_Missense_Mutation_p.G319V|SERPINA1_uc001ydc.3_Missense_Mutation_p.G319V|SERPINA1_uc001yda.1_Missense_Mutation_p.G319V	NM_000295	NP_000286	P01009	A1AT_HUMAN	serine proteinase inhibitor, clade A, member 1	319					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			skin(1)	1		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	ATCATAGGTTCCAGTAATGGA	0.522									Alpha-1-Antitrypsin_Deficiency				101	69	---	---	---	---	PASS
GABRG3	2567	broad.mit.edu	37	15	27725806	27725806	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:27725806C>T	uc001zbg.1	+	6	751	c.585C>T	c.(583-585)CCC>CCT	p.P195P	GABRG3_uc001zbf.2_Silent_p.P195P	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	195	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		ATGGCTATCCCAAAGAAGAAA	0.353													3	33	---	---	---	---	PASS
ACTC1	70	broad.mit.edu	37	15	35085622	35085622	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:35085622T>C	uc001ziu.1	-	3	521	c.278A>G	c.(277-279)TAC>TGC	p.Y93C	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	93					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GAGCTCATTGTAGAAGGTGTG	0.572													71	120	---	---	---	---	PASS
SPTBN5	51332	broad.mit.edu	37	15	42144471	42144471	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:42144471C>T	uc001zos.2	-	62	10721	c.10388G>A	c.(10387-10389)GGG>GAG	p.G3463E		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3498					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCCAGCTCTCCCGGGCTTCAG	0.647													8	13	---	---	---	---	PASS
SPATA5L1	79029	broad.mit.edu	37	15	45697670	45697670	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:45697670G>T	uc001zve.2	+	2	1351	c.1242G>T	c.(1240-1242)GAG>GAT	p.E414D	SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	414						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		TCTGTAGGGAGGCTGCCATGC	0.428													75	84	---	---	---	---	PASS
SEMA6D	80031	broad.mit.edu	37	15	48063194	48063194	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:48063194A>G	uc010bek.2	+	19	2794	c.2434A>G	c.(2434-2436)AGT>GGT	p.S812G	SEMA6D_uc001zvw.2_Missense_Mutation_p.S750G|SEMA6D_uc001zvy.2_Missense_Mutation_p.S812G|SEMA6D_uc001zvz.2_Missense_Mutation_p.S756G|SEMA6D_uc001zwa.2_3'UTR|SEMA6D_uc001zwb.2_Missense_Mutation_p.S750G|SEMA6D_uc001zwc.2_Missense_Mutation_p.S737G	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	812	Cytoplasmic (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TTTTCCGTCTAGTCCGCCACC	0.502													66	117	---	---	---	---	PASS
DYX1C1	161582	broad.mit.edu	37	15	55790004	55790004	+	Silent	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:55790004A>G	uc002adc.2	-	3	545	c.177T>C	c.(175-177)GAT>GAC	p.D59D	CCPG1_uc002acy.2_5'UTR|DYX1C1_uc010ugh.1_RNA|DYX1C1_uc010ugi.1_RNA|DYX1C1_uc002adb.2_Silent_p.D59D|DYX1C1_uc002add.2_Silent_p.D59D	NM_130810	NP_570722	Q8WXU2	DYXC1_HUMAN	dyslexia susceptibility 1 candidate 1 isoform a	59	CS.|Mediates interaction with ESR1 and STUB1.				neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			skin(1)	1				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		TGCTGCTCTCATCGTCTATGG	0.408													101	160	---	---	---	---	PASS
MIR1272	100302184	broad.mit.edu	37	15	65054705	65054705	+	RNA	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:65054705T>C	hsa-mir-1272|MI0006408	-			c.10T>C			RBPMS2_uc002anq.2_Intron																	0						CGCACCCAGATCTGATCTGGC	0.493													54	94	---	---	---	---	PASS
IGDCC4	57722	broad.mit.edu	37	15	65680905	65680905	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:65680905C>A	uc002aou.1	-	16	2937	c.2727G>T	c.(2725-2727)GAG>GAT	p.E909D	IGDCC4_uc002aot.1_Missense_Mutation_p.E497D	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	909	Extracellular (Potential).|Fibronectin type-III 5.					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGCCATGGACCTCAGCACTGA	0.637													67	122	---	---	---	---	PASS
ITGA11	22801	broad.mit.edu	37	15	68603377	68603377	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:68603377G>A	uc002ari.2	-	26	3216	c.3129C>T	c.(3127-3129)TAC>TAT	p.Y1043Y	ITGA11_uc010bib.2_Silent_p.Y1044Y	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	1043	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GGGTGGGCCGGTACTCAGTGC	0.587													9	18	---	---	---	---	PASS
PKM2	5315	broad.mit.edu	37	15	72499082	72499082	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr15:72499082C>A	uc002atx.1	-	8	1368	c.1127G>T	c.(1126-1128)CGC>CTC	p.R376L	PKM2_uc002ats.1_Missense_Mutation_p.R43L|PKM2_uc002att.1_Missense_Mutation_p.R142L|PKM2_uc002atu.1_Missense_Mutation_p.R142L|PKM2_uc010bit.1_Missense_Mutation_p.R381L|PKM2_uc010uki.1_Missense_Mutation_p.R450L|PKM2_uc002atv.1_Missense_Mutation_p.R411L|PKM2_uc002atw.1_Missense_Mutation_p.R376L|PKM2_uc002aty.1_Missense_Mutation_p.R376L|PKM2_uc010ukj.1_Missense_Mutation_p.R361L|PKM2_uc010ukk.1_Missense_Mutation_p.R302L|PKM2_uc010biu.1_Missense_Mutation_p.R397L|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	376	Interaction with POU5F1.				glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	GTGCTGCATGCGCACAGCCTC	0.592													39	63	---	---	---	---	PASS
CREBBP	1387	broad.mit.edu	37	16	3828022	3828022	+	Silent	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr16:3828022C>T	uc002cvv.2	-	10	2307	c.2103G>A	c.(2101-2103)GTG>GTA	p.V701V	CREBBP_uc002cvw.2_Silent_p.V663V	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	701					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TTGGAGGTCTCACAGGTTGTG	0.502			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				103	74	---	---	---	---	PASS
CRYM	1428	broad.mit.edu	37	16	21281170	21281170	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr16:21281170C>A	uc002dik.2	-	4	515	c.430G>T	c.(430-432)GCT>TCT	p.A144S	CRYM_uc010bwq.1_RNA|CRYM_uc002dil.2_Missense_Mutation_p.A102S|CRYM_uc002dim.2_Missense_Mutation_p.A144S	NM_001888	NP_001879	Q14894	CRYM_HUMAN	crystallin, mu isoform 1	144	NADP.				negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity				0				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	TGGACCCCAGCCCCAAGGATG	0.527													46	40	---	---	---	---	PASS
TEPP	374739	broad.mit.edu	37	16	58011824	58011824	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr16:58011824C>A	uc002emw.3	+	2	306	c.269C>A	c.(268-270)GCG>GAG	p.A90E	TEPP_uc002emv.3_Missense_Mutation_p.A90E	NM_199456	NP_955535	Q6URK8	TEPP_HUMAN	testis/prostate/placenta-expressed protein	90						extracellular region				kidney(1)|central_nervous_system(1)|skin(1)	3						AACCAGCTGGCGGGCGTGAAG	0.657													51	19	---	---	---	---	PASS
FANCA	2175	broad.mit.edu	37	16	89809333	89809333	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr16:89809333C>G	uc002fou.1	-	37	3682	c.3640G>C	c.(3640-3642)GAG>CAG	p.E1214Q	FANCA_uc010vpn.1_Missense_Mutation_p.E1214Q|FANCA_uc010vpo.1_Missense_Mutation_p.E300Q	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	1214					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GAGGCAGCCTCAGGGGAGAGG	0.542			D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				48	22	---	---	---	---	PASS
KIF1C	10749	broad.mit.edu	37	17	4910576	4910576	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:4910576G>C	uc002gan.1	+	15	1680	c.1354G>C	c.(1354-1356)GCT>CCT	p.A452P		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	452	Potential.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GAAGATTATAGCTGAGCTGAA	0.582													13	7	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7578272	7578272	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:7578272G>C	uc002gim.2	-	6	771	c.577C>G	c.(577-579)CAT>GAT	p.H193D	TP53_uc002gig.1_Missense_Mutation_p.H193D|TP53_uc002gih.2_Missense_Mutation_p.H193D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61D|TP53_uc010cng.1_Missense_Mutation_p.H61D|TP53_uc002gii.1_Missense_Mutation_p.H61D|TP53_uc010cnh.1_Missense_Mutation_p.H193D|TP53_uc010cni.1_Missense_Mutation_p.H193D|TP53_uc002gij.2_Missense_Mutation_p.H193D|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100D|TP53_uc002gio.2_Missense_Mutation_p.H61D|TP53_uc010vug.1_Missense_Mutation_p.H154D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(29)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.P191fs*53(2)|p.H193H(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGATAAGATGCTGAGGAGGG	0.557		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			43	23	---	---	---	---	PASS
MYH2	4620	broad.mit.edu	37	17	10431192	10431192	+	Splice_Site	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:10431192C>G	uc010coi.2	-	28	3873	c.3745_splice	c.e28-1	p.G1249_splice	uc002gml.1_Intron|MYH2_uc002gmp.3_Splice_Site_p.G1249_splice|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CTAGGTTTCCCTATAGAAGAA	0.398													94	39	---	---	---	---	PASS
MYO15A	51168	broad.mit.edu	37	17	18023903	18023903	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:18023903G>C	uc010vxh.1	+	2	2127	c.1789G>C	c.(1789-1791)GCG>CCG	p.A597P		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	597	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GAAGGCCCGGGCGGGCGGCCC	0.697													5	1	---	---	---	---	PASS
FBXO47	494188	broad.mit.edu	37	17	37119235	37119235	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:37119235T>C	uc002hrc.2	-	2	244	c.44A>G	c.(43-45)CAG>CGG	p.Q15R		NM_001008777	NP_001008777	Q5MNV8	FBX47_HUMAN	F-box protein 47	15											0						TCTAAGTTTCTGGTTGGGAAT	0.373													137	65	---	---	---	---	PASS
CDC42EP4	23580	broad.mit.edu	37	17	71281876	71281876	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:71281876T>C	uc002jjn.2	-	2	911	c.764A>G	c.(763-765)TAC>TGC	p.Y255C	CDC42EP4_uc002jjo.2_Missense_Mutation_p.Y255C|CDC42EP4_uc002jjp.1_Missense_Mutation_p.Y185C	NM_012121	NP_036253	Q9H3Q1	BORG4_HUMAN	Cdc42 effector protein 4	255					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|cytoplasm|endomembrane system|membrane|microtubule cytoskeleton	GTP-Rho binding				0			LUSC - Lung squamous cell carcinoma(166;0.0352)|Lung(188;0.0711)			CGCCACGGCGTACGGGGGAGC	0.687													10	10	---	---	---	---	PASS
DSC1	1823	broad.mit.edu	37	18	28721973	28721973	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr18:28721973A>G	uc002kwn.2	-	9	1511	c.1249T>C	c.(1249-1251)TGT>CGT	p.C417R	DSC1_uc002kwm.2_Missense_Mutation_p.C417R	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	417	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTGACAACACACAGCACTCCT	0.323													39	117	---	---	---	---	PASS
MAPRE2	10982	broad.mit.edu	37	18	32677486	32677486	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr18:32677486G>A	uc002kyg.2	+	3	507	c.327G>A	c.(325-327)AAG>AAA	p.K109K	MAPRE2_uc010xcb.1_Silent_p.K66K|MAPRE2_uc010xcc.1_Silent_p.K97K|MAPRE2_uc002kyf.2_Silent_p.K109K|MAPRE2_uc002kyh.2_Silent_p.K56K|MAPRE2_uc010xcd.1_Silent_p.K66K	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	109	CH.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						TTCAAGCAAAGCTGGAACATG	0.378													44	58	---	---	---	---	PASS
RTTN	25914	broad.mit.edu	37	18	67741225	67741225	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr18:67741225C>A	uc002lkp.2	-	34	4638	c.4570G>T	c.(4570-4572)GAT>TAT	p.D1524Y	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.D612Y	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1524							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				AATGAGTCATCTAAACCTGCA	0.413													35	64	---	---	---	---	PASS
TLE2	7089	broad.mit.edu	37	19	3006571	3006571	+	Silent	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:3006571C>A	uc002lww.2	-	15	1610	c.1347G>T	c.(1345-1347)CGG>CGT	p.R449R	TLE2_uc010xhb.1_Silent_p.R116R|TLE2_uc010dth.2_Silent_p.R450R|TLE2_uc010xhc.1_Silent_p.R327R|TLE2_uc010dti.2_Silent_p.R463R|TLE2_uc010xhd.1_Silent_p.R357R	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	449					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGCAGCTGCCGGGCGTGCC	0.682													4	5	---	---	---	---	PASS
TLE2	7089	broad.mit.edu	37	19	3006572	3006572	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:3006572C>G	uc002lww.2	-	15	1609	c.1346G>C	c.(1345-1347)CGG>CCG	p.R449P	TLE2_uc010xhb.1_Missense_Mutation_p.R116P|TLE2_uc010dth.2_Missense_Mutation_p.R450P|TLE2_uc010xhc.1_Missense_Mutation_p.R327P|TLE2_uc010dti.2_Missense_Mutation_p.R463P|TLE2_uc010xhd.1_Missense_Mutation_p.R357P	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	449					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCAGCTGCCGGGCGTGCCG	0.682													4	5	---	---	---	---	PASS
C3	718	broad.mit.edu	37	19	6707088	6707088	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:6707088C>A	uc002mfm.2	-	17	2306	c.2244G>T	c.(2242-2244)AGG>AGT	p.R748S		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	748		Cleavage; by C3 convertase.			complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGGACCTACTCCTGGCCAGGC	0.697													16	20	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9090002	9090002	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:9090002C>A	uc002mkp.2	-	1	2017	c.1813G>T	c.(1813-1815)GTT>TTT	p.V605F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	605	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAGTGGGAACAGCAAACTGA	0.547													30	73	---	---	---	---	PASS
ZNF700	90592	broad.mit.edu	37	19	12060436	12060436	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:12060436G>C	uc002msu.2	+	4	1723	c.1597G>C	c.(1597-1599)GAG>CAG	p.E533Q	ZNF700_uc010xme.1_Missense_Mutation_p.E551Q|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	533					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCACACTGGAGAGAAACCCTA	0.398													58	89	---	---	---	---	PASS
CCDC123	84902	broad.mit.edu	37	19	33424558	33424558	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:33424558G>A	uc002nty.2	-	8	774	c.685C>T	c.(685-687)CGT>TGT	p.R229C	CCDC123_uc002ntx.2_Translation_Start_Site|CCDC123_uc010edg.2_RNA|CCDC123_uc002ntz.1_Missense_Mutation_p.R229C|CCDC123_uc002nua.2_Missense_Mutation_p.R229C	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	229						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					TATCTTTGACGTGCTCTACCA	0.318													75	166	---	---	---	---	PASS
NPHS1	4868	broad.mit.edu	37	19	36330456	36330456	+	Missense_Mutation	SNP	C	A	A	rs114849139	by1000genomes	TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:36330456C>A	uc002oby.2	-	21	2869	c.2869G>T	c.(2869-2871)GTG>TTG	p.V957L	NPHS1_uc010eem.1_5'Flank	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	957	Fibronectin type-III.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCCAGCCCCACGGAGTGTGGG	0.572													36	90	---	---	---	---	PASS
GMFG	9535	broad.mit.edu	37	19	39819164	39819164	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:39819164C>T	uc002okz.3	-	7	492	c.382G>A	c.(382-384)GAC>AAC	p.D128N	GMFG_uc002okx.3_3'UTR	NM_004877	NP_004868	O60234	GMFG_HUMAN	glia maturation factor, gamma	128	ADF-H.				protein phosphorylation	intracellular	actin binding|enzyme activator activity|growth factor activity|protein kinase inhibitor activity			skin(1)	1	all_cancers(60;2.5e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.15e-27)|all cancers(26;1.3e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			TCAGTGAGGTCATCAGTGGTG	0.448													41	167	---	---	---	---	PASS
EXOC3L2	90332	broad.mit.edu	37	19	45731017	45731017	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:45731017C>A	uc002pay.1	-	5	348	c.307G>T	c.(307-309)GTG>TTG	p.V103L		NM_138568	NP_612635	Q2M3D2	EX3L2_HUMAN	exocyst complex component 3-like 2	103										ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00883)		AATCGCTCCACACGCTGCTGG	0.632													13	6	---	---	---	---	PASS
PPP2R1A	5518	broad.mit.edu	37	19	52723042	52723042	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:52723042G>T	uc002pyp.2	+	10	1386	c.1227G>T	c.(1225-1227)GTG>GTT	p.V409V	PPP2R1A_uc010ydk.1_Silent_p.V354V|PPP2R1A_uc002pyq.2_Silent_p.V230V	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	409	HEAT 11.|PP2A subunit C binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CTGCCATTGTGGAGCTGGCTG	0.622			Mis		clear cell ovarian carcinoma								5	45	---	---	---	---	PASS
PPP2R1A	5518	broad.mit.edu	37	19	52723043	52723043	+	Nonsense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:52723043G>T	uc002pyp.2	+	10	1387	c.1228G>T	c.(1228-1230)GAG>TAG	p.E410*	PPP2R1A_uc010ydk.1_Nonsense_Mutation_p.E355*|PPP2R1A_uc002pyq.2_Nonsense_Mutation_p.E231*	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	410	HEAT 11.|PP2A subunit C binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TGCCATTGTGGAGCTGGCTGA	0.627			Mis		clear cell ovarian carcinoma								4	47	---	---	---	---	PASS
PPP1R12C	54776	broad.mit.edu	37	19	55602904	55602904	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:55602904T>A	uc002qix.2	-	22	2301	c.2285A>T	c.(2284-2286)GAC>GTC	p.D762V	PPP1R12C_uc010yfs.1_Missense_Mutation_p.D687V|PPP1R12C_uc002qiy.2_Missense_Mutation_p.D760V	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	762	Potential.					cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GCGCTGGTTGTCAGCGCGGAG	0.647													29	11	---	---	---	---	PASS
NLRP5	126206	broad.mit.edu	37	19	56520216	56520216	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:56520216C>T	uc002qmj.2	+	3	505	c.505C>T	c.(505-507)CCA>TCA	p.P169S	NLRP5_uc002qmi.2_Missense_Mutation_p.P169S	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	169						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GGAAAAAGTGCCAGGTTAGAG	0.294													3	22	---	---	---	---	PASS
SLC27A5	10998	broad.mit.edu	37	19	59012686	59012686	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr19:59012686G>A	uc002qtc.2	-	4	1259	c.1149C>T	c.(1147-1149)GGC>GGT	p.G383G	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	383	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GCAGGAGCTCGCCCACATACA	0.542													6	199	---	---	---	---	PASS
CPXM1	56265	broad.mit.edu	37	20	2774852	2774852	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr20:2774852C>A	uc002wgu.2	-	14	2253	c.2189G>T	c.(2188-2190)AGG>ATG	p.R730M	CPXM1_uc010gas.2_Missense_Mutation_p.R656M	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	730					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						CTTCTGTCCCCTTAGCCGCTC	0.607													45	83	---	---	---	---	PASS
C20orf26	26074	broad.mit.edu	37	20	20180530	20180530	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr20:20180530C>T	uc002wru.2	+	17	1992	c.1916C>T	c.(1915-1917)GCG>GTG	p.A639V	C20orf26_uc010zse.1_Missense_Mutation_p.A619V	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	639										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCATCAAAGGCGGTCTCCAAG	0.617													62	146	---	---	---	---	PASS
C20orf26	26074	broad.mit.edu	37	20	20269293	20269293	+	Missense_Mutation	SNP	C	T	T	rs140045830		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr20:20269293C>T	uc002wru.2	+	23	2913	c.2837C>T	c.(2836-2838)ACG>ATG	p.T946M	C20orf26_uc002wrw.2_Intron	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	946										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		GATTATGAAACGTTTAAAGCC	0.408													146	328	---	---	---	---	PASS
CST8	10047	broad.mit.edu	37	20	23472353	23472353	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr20:23472353G>T	uc002wth.1	+	2	406	c.49G>T	c.(49-51)GCC>TCC	p.A17S		NM_005492	NP_005483	O60676	CST8_HUMAN	cystatin 8 precursor	17						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CATTCCCCTGGCCCTGGTGGC	0.567													74	162	---	---	---	---	PASS
NPBWR2	2832	broad.mit.edu	37	20	62737573	62737573	+	Silent	SNP	G	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr20:62737573G>C	uc011abt.1	-	1	612	c.612C>G	c.(610-612)CCC>CCG	p.P204P		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	204	Extracellular (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					AGACCTGCTCGGGCCACGGGA	0.627													13	22	---	---	---	---	PASS
NCAM2	4685	broad.mit.edu	37	21	22804589	22804589	+	Missense_Mutation	SNP	C	A	A	rs35592118		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr21:22804589C>A	uc002yld.1	+	12	1891	c.1642C>A	c.(1642-1644)CAT>AAT	p.H548N	NCAM2_uc011acb.1_Missense_Mutation_p.H406N	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor	548	Fibronectin type-III 1.|Extracellular (Potential).				neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TGTACGCTCCCATGGAGTTCA	0.408													53	23	---	---	---	---	PASS
GRIK1	2897	broad.mit.edu	37	21	31023582	31023582	+	Silent	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr21:31023582A>G	uc002yno.1	-	6	1274	c.810T>C	c.(808-810)TAT>TAC	p.Y270Y	GRIK1_uc002ynn.2_Silent_p.Y270Y|GRIK1_uc011acs.1_Silent_p.Y270Y|GRIK1_uc011act.1_Silent_p.Y214Y|GRIK1_uc010glq.1_Silent_p.Y128Y|GRIK1_uc002ynr.2_Silent_p.Y270Y	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	270	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CACTGTACCTATAGAGTTCCA	0.383													61	23	---	---	---	---	PASS
XKR3	150165	broad.mit.edu	37	22	17264895	17264895	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr22:17264895C>T	uc002zlv.2	-	4	1092	c.994G>A	c.(994-996)GAC>AAC	p.D332N	XKR3_uc011agf.1_Missense_Mutation_p.D332N	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	332						integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ATTATTTTGTCATCTGACAAC	0.408													70	200	---	---	---	---	PASS
MYO18B	84700	broad.mit.edu	37	22	26164516	26164516	+	Silent	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr22:26164516G>A	uc003abz.1	+	4	883	c.633G>A	c.(631-633)CCG>CCA	p.P211P	MYO18B_uc003aca.1_Silent_p.P92P|MYO18B_uc010guy.1_Silent_p.P92P|MYO18B_uc010guz.1_Silent_p.P92P|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	211						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						TCTTGGCCCCGAAAGCTGAGA	0.597													14	9	---	---	---	---	PASS
OSBP2	23762	broad.mit.edu	37	22	31289967	31289967	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr22:31289967T>C	uc003aiy.1	+	12	2458	c.2354T>C	c.(2353-2355)CTG>CCG	p.L785P	OSBP2_uc011ala.1_Missense_Mutation_p.L619P|OSBP2_uc010gwc.1_Missense_Mutation_p.L612P|OSBP2_uc011alb.1_Missense_Mutation_p.L736P|OSBP2_uc003aiz.1_Missense_Mutation_p.L784P|OSBP2_uc003aja.1_Missense_Mutation_p.L418P|OSBP2_uc011alc.1_Missense_Mutation_p.L527P|OSBP2_uc003ajb.2_Missense_Mutation_p.L330P|OSBP2_uc011ald.1_Missense_Mutation_p.L329P|OSBP2_uc010gwd.1_Intron	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	785					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						GCCAAGCTGCTGTGGAAGAAG	0.592													4	8	---	---	---	---	PASS
CERK	64781	broad.mit.edu	37	22	47087573	47087573	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr22:47087573C>G	uc003bia.2	-	11	1335	c.1228G>C	c.(1228-1230)GCT>CCT	p.A410P	CERK_uc010hae.2_Missense_Mutation_p.A212P	NM_022766	NP_073603	Q8TCT0	CERK1_HUMAN	ceramide kinase	410					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			skin(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AAGTGGGCAGCCGGGGAGAGG	0.572													30	43	---	---	---	---	PASS
GPR143	4935	broad.mit.edu	37	X	9728759	9728759	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:9728759C>G	uc004cst.1	-	2	418	c.418G>C	c.(418-420)GCG>CCG	p.A140P		NM_000273	NP_000264	P51810	GP143_HUMAN	G protein-coupled receptor 143	120	Extracellular (Potential).				calcium-mediated signaling using intracellular calcium source|eye pigment biosynthetic process|melanosome organization|melanosome transport|phosphatidylinositol-mediated signaling|regulation of calcium-mediated signaling|visual perception	apical plasma membrane|Golgi apparatus|integral to membrane|lysosomal membrane|melanosome membrane|membrane fraction	dopamine binding|L-DOPA receptor activity|protein binding|tyrosine binding			ovary(1)	1		Hepatocellular(5;0.000888)				GGACTCACCGCACTCCCCACG	0.393													7	21	---	---	---	---	PASS
CLCN4	1183	broad.mit.edu	37	X	10182002	10182002	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:10182002G>A	uc004csy.3	+	11	2288	c.1858G>A	c.(1858-1860)GAG>AAG	p.E620K	CLCN4_uc011mid.1_Missense_Mutation_p.E526K	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	620	CBS 1.|Cytoplasmic (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						CATGACTGTCGAGGACGTGGA	0.632													7	84	---	---	---	---	PASS
AMELX	265	broad.mit.edu	37	X	11316790	11316790	+	Silent	SNP	A	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:11316790A>G	uc004cut.2	+	5	335	c.267A>G	c.(265-267)CCA>CCG	p.P89P	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Silent_p.P103P|AMELX_uc004cuu.2_Silent_p.P73P	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	89					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						CAGTGGTGCCAGCTCAGCAGC	0.622													79	199	---	---	---	---	PASS
EGFL6	25975	broad.mit.edu	37	X	13651197	13651197	+	Missense_Mutation	SNP	T	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:13651197T>G	uc004cvi.2	+	12	1885	c.1645T>G	c.(1645-1647)TTA>GTA	p.L549V	EGFL6_uc004cvj.2_Missense_Mutation_p.L550V	NM_015507	NP_056322	Q8IUX8	EGFL6_HUMAN	epidermal growth factor-like protein 6	549					cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)	2						AGATAGCCTTTTATCTGTGGA	0.398													9	263	---	---	---	---	PASS
PHEX	5251	broad.mit.edu	37	X	22245715	22245715	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:22245715T>C	uc004dah.2	+	20	2260	c.2057T>C	c.(2056-2058)CTG>CCG	p.L686P	PHEX_uc011mjr.1_Missense_Mutation_p.L686P|PHEX_uc011mjs.1_Missense_Mutation_p.L589P	NM_000444	NP_000435	P78562	PHEX_HUMAN	phosphate-regulating neutral endopeptidase	686					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3						CTCTTCTTCCTGAGTTATGCT	0.458													104	138	---	---	---	---	PASS
PDK3	5165	broad.mit.edu	37	X	24483633	24483633	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:24483633C>T	uc004dbg.2	+	1	290	c.61C>T	c.(61-63)CGC>TGC	p.R21C	PDK3_uc004dbh.2_Missense_Mutation_p.R21C	NM_005391	NP_005382	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase 3 isoform 2	21					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GCGCTACTCGCGCTTTTCGCC	0.697													13	27	---	---	---	---	PASS
CYBB	1536	broad.mit.edu	37	X	37663354	37663354	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:37663354G>T	uc004ddr.2	+	9	1183	c.1122G>T	c.(1120-1122)CAG>CAT	p.Q374H	CYBB_uc011mke.1_RNA|CYBB_uc011mkf.1_Missense_Mutation_p.Q342H|CYBB_uc011mkg.1_Missense_Mutation_p.Q107H	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	374	Cytoplasmic (Potential).|FAD-binding FR-type.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GTGATAAGCAGGAGTTTCAAG	0.453													61	121	---	---	---	---	PASS
SYTL5	94122	broad.mit.edu	37	X	37969625	37969625	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:37969625T>A	uc004ddu.2	+	14	2020	c.1486T>A	c.(1486-1488)TGG>AGG	p.W496R	SYTL5_uc004ddv.2_Missense_Mutation_p.W496R|SYTL5_uc004ddx.2_Missense_Mutation_p.W518R	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	496	C2 1.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						GCTCTCAGTCTGGCACTATGA	0.448													175	194	---	---	---	---	PASS
PORCN	64840	broad.mit.edu	37	X	48372703	48372703	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:48372703G>T	uc010nie.1	+	9	953	c.795G>T	c.(793-795)ACG>ACT	p.T265T	PORCN_uc004djr.1_Silent_p.T260T|PORCN_uc004djs.1_Silent_p.T254T|PORCN_uc004djt.1_Silent_p.T183T|PORCN_uc011mlx.1_Silent_p.T183T|PORCN_uc004dju.1_Silent_p.T123T|PORCN_uc004djv.1_Silent_p.T265T|PORCN_uc004djw.1_Silent_p.T259T	NM_203475	NP_982301	Q9H237	PORCN_HUMAN	porcupine isoform D	265	Helical; (Potential).				Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			ovary(2)|central_nervous_system(1)	3						CCGAGGCCACGGCCACGTTGG	0.627													68	77	---	---	---	---	PASS
TBC1D25	4943	broad.mit.edu	37	X	48418069	48418069	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:48418069T>A	uc004dka.1	+	6	884	c.773T>A	c.(772-774)ATG>AAG	p.M258K	TBC1D25_uc011mly.1_Missense_Mutation_p.M200K|TBC1D25_uc004dkb.1_Missense_Mutation_p.M4K|TBC1D25_uc011mlz.1_Missense_Mutation_p.M4K|TBC1D25_uc011mma.1_Missense_Mutation_p.M4K|TBC1D25_uc004dkc.1_Missense_Mutation_p.M4K|TBC1D25_uc011mmb.1_Missense_Mutation_p.M262K|TBC1D25_uc011mmc.1_Missense_Mutation_p.M4K|TBC1D25_uc011mmd.1_Missense_Mutation_p.M4K	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	258	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)	1						ATGGACTACATGAAACGCAAG	0.592													43	66	---	---	---	---	PASS
CACNA1F	778	broad.mit.edu	37	X	49074999	49074999	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:49074999G>A	uc004dnb.2	-	24	2938	c.2876C>T	c.(2875-2877)TCC>TTC	p.S959F	CACNA1F_uc010nip.2_Missense_Mutation_p.S948F	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	959	III.|Extracellular (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GATGGCGCTGGAGCTGGGGAA	0.622													7	26	---	---	---	---	PASS
FAM120C	54954	broad.mit.edu	37	X	54161493	54161493	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:54161493C>G	uc004dsz.3	-	7	1470	c.1387G>C	c.(1387-1389)GGA>CGA	p.G463R	FAM120C_uc011moh.1_Missense_Mutation_p.G463R	NM_017848	NP_060318	Q9NX05	F120C_HUMAN	hypothetical protein LOC54954	463										ovary(1)|central_nervous_system(1)	2						GAGTTGGGTCCCACTGGGAAT	0.458													62	73	---	---	---	---	PASS
ZC3H12B	340554	broad.mit.edu	37	X	64721936	64721936	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:64721936T>C	uc010nko.2	+	5	1334	c.1325T>C	c.(1324-1326)ATT>ACT	p.I442T		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	442							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						TGGCTGTCCATTGCCCGTAAG	0.567													19	21	---	---	---	---	PASS
RPS6KA6	27330	broad.mit.edu	37	X	83362666	83362666	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:83362666C>G	uc004eej.1	-	13	1153	c.1076G>C	c.(1075-1077)TGT>TCT	p.C359S	RPS6KA6_uc011mqt.1_Missense_Mutation_p.C359S|RPS6KA6_uc011mqu.1_Missense_Mutation_p.C256S	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	359	AGC-kinase C-terminal.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						AGGATCAAAACAAAAAGTATC	0.299													3	77	---	---	---	---	PASS
NAP1L3	4675	broad.mit.edu	37	X	92927456	92927456	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:92927456C>A	uc004efq.2	-	1	1153	c.848G>T	c.(847-849)AGA>ATA	p.R283I	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	283					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						CTCAGGAACTCTTTTATGAGT	0.453													107	129	---	---	---	---	PASS
CENPI	2491	broad.mit.edu	37	X	100402956	100402956	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:100402956A>T	uc004egx.2	+	19	2170	c.1900A>T	c.(1900-1902)AGC>TGC	p.S634C	CENPI_uc011mrg.1_Missense_Mutation_p.S634C	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	634					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						CAATTTCAGCAGCAAGACTTA	0.358													89	133	---	---	---	---	PASS
MUM1L1	139221	broad.mit.edu	37	X	105449901	105449901	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:105449901A>T	uc004emf.1	+	4	1125	c.476A>T	c.(475-477)GAG>GTG	p.E159V	MUM1L1_uc004emg.1_Missense_Mutation_p.E159V	NM_152423	NP_689636	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	159										ovary(2)|pancreas(1)|skin(1)	4						GCATCTTCAGAGAGTGATGAT	0.428													20	47	---	---	---	---	PASS
VSIG1	340547	broad.mit.edu	37	X	107316490	107316490	+	Silent	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:107316490C>A	uc004eno.2	+	5	740	c.579C>A	c.(577-579)ACC>ACA	p.T193T	VSIG1_uc011msk.1_Silent_p.T229T	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	193	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						ACCCAACCACCGGGATTTTGG	0.428													146	377	---	---	---	---	PASS
LONRF3	79836	broad.mit.edu	37	X	118124510	118124510	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:118124510G>A	uc004eqw.2	+	5	1433	c.1402G>A	c.(1402-1404)GCT>ACT	p.A468T	LONRF3_uc004eqx.2_Missense_Mutation_p.A427T|LONRF3_uc004eqy.2_RNA|LONRF3_uc004eqz.2_Missense_Mutation_p.A212T	NM_001031855	NP_001027026	Q496Y0	LONF3_HUMAN	LON peptidase N-terminal domain and ring finger	468	RING-type 2.				proteolysis		ATP-dependent peptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)	2						CCTTGAATGCGCTCTATGTAT	0.468													86	115	---	---	---	---	PASS
KIAA1210	57481	broad.mit.edu	37	X	118222607	118222607	+	Silent	SNP	A	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:118222607A>C	uc004era.3	-	11	2586	c.2586T>G	c.(2584-2586)ACT>ACG	p.T862T		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	862										ovary(4)|skin(1)	5						AATCATCAGAAGTGTTGTACT	0.498													24	45	---	---	---	---	PASS
SEPT6	23157	broad.mit.edu	37	X	118763348	118763348	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:118763348G>T	uc004erv.2	-	9	1478	c.1213C>A	c.(1213-1215)CTG>ATG	p.L405M	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Missense_Mutation_p.L405M|SEPT6_uc004ert.2_Missense_Mutation_p.L405M|SEPT6_uc004eru.2_Missense_Mutation_p.L405M|SEPT6_uc004erw.2_Missense_Mutation_p.L347M|SEPT6_uc011mtv.1_Missense_Mutation_p.L347M|SEPT6_uc011mtw.1_Missense_Mutation_p.L435M	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	405	Potential.				cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						GACTGGAGCAGCTCAGCCGCC	0.512													115	134	---	---	---	---	PASS
ENOX2	10495	broad.mit.edu	37	X	129837178	129837178	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:129837178T>C	uc004evw.2	-	5	518	c.100A>G	c.(100-102)ATG>GTG	p.M34V	ENOX2_uc004evx.2_Missense_Mutation_p.M5V|ENOX2_uc004evy.2_Missense_Mutation_p.M5V	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	34					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						GGATCAGACATAGGTAGTGTC	0.403													57	164	---	---	---	---	PASS
ARHGAP36	158763	broad.mit.edu	37	X	130218282	130218282	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:130218282C>A	uc004evz.2	+	5	994	c.649C>A	c.(649-651)CAA>AAA	p.Q217K	ARHGAP36_uc004ewa.2_Missense_Mutation_p.Q205K|ARHGAP36_uc004ewb.2_Missense_Mutation_p.Q186K|ARHGAP36_uc004ewc.2_Missense_Mutation_p.Q81K	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	217					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TCCAATTGGCCAACGACTTCT	0.498													28	69	---	---	---	---	PASS
ZNF75D	7626	broad.mit.edu	37	X	134427658	134427658	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:134427658C>T	uc004eyp.2	-	3	3064	c.409G>A	c.(409-411)GAG>AAG	p.E137K	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_5'Flank|ZNF75D_uc004eyo.2_Missense_Mutation_p.E137K	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	137					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CTTCTTACCTCATTCTTTGTT	0.438													110	94	---	---	---	---	PASS
MAMLD1	10046	broad.mit.edu	37	X	149638838	149638838	+	Silent	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:149638838G>T	uc004fee.1	+	3	1069	c.993G>T	c.(991-993)CTG>CTT	p.L331L	MAMLD1_uc011mxt.1_Silent_p.L293L|MAMLD1_uc011mxu.1_Silent_p.L306L|MAMLD1_uc011mxv.1_Silent_p.L306L|MAMLD1_uc011mxw.1_Silent_p.L258L	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	331					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					GGTCTGGTCTGCCTCCTCCAG	0.488													30	66	---	---	---	---	PASS
MTMR1	8776	broad.mit.edu	37	X	149895709	149895709	+	Nonsense_Mutation	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:149895709C>A	uc004fei.2	+	4	486	c.351C>A	c.(349-351)TGC>TGA	p.C117*	MTMR1_uc011mya.1_Nonsense_Mutation_p.C23*|MTMR1_uc004feg.1_Nonsense_Mutation_p.C117*|MTMR1_uc004feh.1_Nonsense_Mutation_p.C125*|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	117	GRAM.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TGTATATCTGCCCATTTATGG	0.368													61	87	---	---	---	---	PASS
GABRQ	55879	broad.mit.edu	37	X	151821678	151821678	+	Silent	SNP	C	A	A			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:151821678C>A	uc004ffp.1	+	9	1853	c.1833C>A	c.(1831-1833)TCC>TCA	p.S611S		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	611						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACAAGTGGTCCCGGTTCCTCT	0.527													116	128	---	---	---	---	PASS
FLNA	2316	broad.mit.edu	37	X	153577267	153577267	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:153577267A>T	uc004fkk.2	-	48	8143	c.7894T>A	c.(7894-7896)TGG>AGG	p.W2632R	FLNA_uc004fki.2_Missense_Mutation_p.W672R|FLNA_uc011mzn.1_Missense_Mutation_p.W765R|FLNA_uc010nuu.1_Missense_Mutation_p.W2624R	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2632	Self-association site, tail.|Filamin 24.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCGTCCCCCCATTTGACCACC	0.667													50	60	---	---	---	---	PASS
MPP1	4354	broad.mit.edu	37	X	154009998	154009998	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chrX:154009998G>T	uc004fmp.1	-	10	1141	c.1026C>A	c.(1024-1026)AAC>AAA	p.N342K	MPP1_uc010nvg.1_Missense_Mutation_p.N322K|MPP1_uc011mzv.1_Missense_Mutation_p.N312K|MPP1_uc004fmq.1_Missense_Mutation_p.N296K|MPP1_uc011mzw.1_Missense_Mutation_p.N325K	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	342	Guanylate kinase-like.|Interaction with MPP5.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGCAGAGATGTTCCTCGTCA	0.468													166	207	---	---	---	---	PASS
CUL9	23113	broad.mit.edu	37	6	43190552	43190552	+	Frame_Shift_Del	DEL	C	-	-			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr6:43190552delC	uc003ouk.2	+	38	7143	c.7068delC	c.(7066-7068)AGCfs	p.S2356fs	CUL9_uc003oul.2_Frame_Shift_Del_p.S2328fs|CUL9_uc010jyk.2_Frame_Shift_Del_p.S1508fs|CUL9_uc003oun.2_Frame_Shift_Del_p.S151fs	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2356					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GCTTCTACAGCCAGGACGCAG	0.627													106	52	---	---	---	---	
LCN8	138307	broad.mit.edu	37	9	139651601	139651602	+	Frame_Shift_Ins	INS	-	C	C			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr9:139651601_139651602insC	uc004cjb.1	-	2	392_393	c.43_44insG	c.(43-45)GAAfs	p.E15fs	LCN8_uc004cja.2_5'Flank|LCN8_uc004cjc.1_Frame_Shift_Ins_p.E15fs	NM_178469	NP_848564	Q6JVE9	LCN8_HUMAN	lipocalin 8	38					transport	extracellular region	binding			pancreas(1)	1	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;5.56e-06)|Epithelial(140;8.32e-05)		CACACCGACTTCCCTCCAGAAT	0.624													13	17	---	---	---	---	
OR4D6	219983	broad.mit.edu	37	11	59225269	59225269	+	Frame_Shift_Del	DEL	C	-	-			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr11:59225269delC	uc010rku.1	+	1	836	c.836delC	c.(835-837)ACCfs	p.T279fs		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	279	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACGGTCATTACCCCCATGCTG	0.502													252	112	---	---	---	---	
NEURL4	84461	broad.mit.edu	37	17	7231109	7231109	+	Frame_Shift_Del	DEL	C	-	-			TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:7231109delC	uc002gga.1	-	2	384	c.377delG	c.(376-378)GGCfs	p.G126fs	NEURL4_uc002ggb.1_Frame_Shift_Del_p.G126fs|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	126	NHR 1.						protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						TACCCACGAGCCCCCCTTCAG	0.622													26	50	---	---	---	---	
CBX4	8535	broad.mit.edu	37	17	77808241	77808249	+	In_Frame_Del	DEL	GTGGTGGTG	-	-	rs3833850		TCGA-60-2719-01A-01D-1522-08	TCGA-60-2719-11A-01D-1522-08									Somatic	Phase_I	Capture				Illumina GAIIx	ee6cc68e-8d2a-41ee-82c6-0fecdf7e6259	7efd4b88-beed-4e5e-b434-2bc0103084e6	g.chr17:77808241_77808249delGTGGTGGTG	uc002jxe.2	-	5	1355_1363	c.1192_1200delCACCACCAC	c.(1192-1200)CACCACCACdel	p.HHH398del		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	398_400	His-rich.|Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGCCGACGGCgtggtggtggtggtggtgg	0.512													13	6	---	---	---	---	
