Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
KAZ	23254	broad.mit.edu	37	1	15428077	15428077	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:15428077C>A	uc001avm.3	+	11	1867	c.1586C>A	c.(1585-1587)GCC>GAC	p.A529D	KAZ_uc001avs.3_5'UTR	NM_201628	NP_963922	Q674X7	KAZRN_HUMAN	kazrin isoform E	529	SAM 2.				keratinization	cornified envelope|cytoplasm|desmosome|nucleus					0						CACTGGGTGGCCAAGGCCTGG	0.592													3	4	---	---	---	---	PASS
EPHB2	2048	broad.mit.edu	37	1	23110939	23110939	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:23110939G>C	uc009vqj.1	+	3	326	c.181G>C	c.(181-183)GTG>CTG	p.V61L	EPHB2_uc001bge.2_Missense_Mutation_p.V61L|EPHB2_uc001bgf.2_Missense_Mutation_p.V61L|EPHB2_uc010odu.1_Missense_Mutation_p.V61L	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	61	Extracellular (Potential).				axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		CACGTACCAGGTGTGCAACGT	0.567									Hereditary_Prostate_Cancer				15	34	---	---	---	---	PASS
RAB42	115273	broad.mit.edu	37	1	28920446	28920446	+	Silent	SNP	C	T	T	rs148146932	byFrequency	TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:28920446C>T	uc001bqu.2	+	2	441	c.135C>T	c.(133-135)ACC>ACT	p.T45T	RAB42_uc001bqv.2_Silent_p.T45T	NM_152304	NP_689517	Q8N4Z0	RAB42_HUMAN	RAB42, member RAS oncogene family	45					small GTPase mediated signal transduction	membrane	GTP binding				0		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00618)|all_lung(284;0.00909)|Breast(348;0.0249)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0577)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00298)|KIRC - Kidney renal clear cell carcinoma(1967;0.00948)|BRCA - Breast invasive adenocarcinoma(304;0.0213)|READ - Rectum adenocarcinoma(331;0.0649)		TCGTGGAGACCTCGGTTAAAA	0.602													9	21	---	---	---	---	PASS
EPB41	2035	broad.mit.edu	37	1	29385131	29385131	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:29385131C>G	uc001brm.1	+	12	1883	c.1876C>G	c.(1876-1878)CCC>GCC	p.P626A	EPB41_uc001brg.1_Missense_Mutation_p.P417A|EPB41_uc001brh.1_Intron|EPB41_uc001bri.1_Intron|EPB41_uc001brj.1_Intron|EPB41_uc001brk.2_Missense_Mutation_p.P626A|EPB41_uc001brl.1_Intron|EPB41_uc009vtl.1_Intron|EPB41_uc009vtm.1_Intron	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	626	Spectrin--actin-binding.				blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		GGTGACAGTACCCACCTCAAA	0.403													3	29	---	---	---	---	PASS
MTF1	4520	broad.mit.edu	37	1	38288049	38288049	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:38288049C>T	uc001cce.1	-	9	1652	c.1511G>A	c.(1510-1512)GGG>GAG	p.G504E	MTF1_uc009vvj.1_Missense_Mutation_p.G195E	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	504						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGCAGAAGCCCCAGCAACAAC	0.587													6	10	---	---	---	---	PASS
ZFYVE9	9372	broad.mit.edu	37	1	52703869	52703869	+	Silent	SNP	G	A	A	rs149478229		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:52703869G>A	uc001cto.2	+	4	952	c.780G>A	c.(778-780)GCG>GCA	p.A260A	ZFYVE9_uc001ctn.2_Silent_p.A260A|ZFYVE9_uc001ctp.2_Silent_p.A260A	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	260					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						CCATGTCTGCGATTACAAGTT	0.438													25	181	---	---	---	---	PASS
LEPROT	54741	broad.mit.edu	37	1	65897531	65897531	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:65897531A>G	uc001dcf.2	+	4	414	c.325A>G	c.(325-327)ATT>GTT	p.I109V	LEPR_uc001dcg.2_Intron|LEPR_uc001dch.2_Intron|LEPR_uc001dci.2_Intron|LEPR_uc009waq.2_Intron|LEPROT_uc009wap.2_Missense_Mutation_p.I118V	NM_017526	NP_059996	O15243	OBRG_HUMAN	leptin receptor gene-related protein	109	Helical; (Potential).					endosome membrane|Golgi membrane|integral to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CAATGCAGTCATTTTCCTTAC	0.393													12	25	---	---	---	---	PASS
LEPR	3953	broad.mit.edu	37	1	66102457	66102457	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:66102457A>G	uc001dci.2	+	20	3459	c.3257A>G	c.(3256-3258)AAA>AGA	p.K1086R	LEPR_uc009waq.2_3'UTR	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	1086	Cytoplasmic (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ACCTCAATCAAAAAGAGAGAG	0.413													8	24	---	---	---	---	PASS
RPAP2	79871	broad.mit.edu	37	1	92798948	92798948	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:92798948C>T	uc001dot.2	+	9	1565	c.1456C>T	c.(1456-1458)CAT>TAT	p.H486Y	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	486						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TGTGATTCAGCATGATTCCAC	0.318													9	13	---	---	---	---	PASS
OTUD7B	56957	broad.mit.edu	37	1	149916922	149916922	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:149916922C>G	uc001etn.2	-	12	1722	c.1366G>C	c.(1366-1368)GAT>CAT	p.D456H		NM_020205	NP_064590	Q6GQQ9	OTU7B_HUMAN	zinc finger protein Cezanne	456					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			CGGGGCTCATCTCCAGCTGAG	0.612													17	20	---	---	---	---	PASS
OR10X1	128367	broad.mit.edu	37	1	158548923	158548923	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:158548923G>C	uc010pin.1	-	1	767	c.767C>G	c.(766-768)ACC>AGC	p.T256S		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGAGGCACAGGTGGTGAAGGC	0.483													25	100	---	---	---	---	PASS
OR6N1	128372	broad.mit.edu	37	1	158735980	158735980	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:158735980G>A	uc010piq.1	-	1	493	c.493C>T	c.(493-495)CGC>TGC	p.R165C		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AATGGGAGGCGTGAAATCAAG	0.502													23	67	---	---	---	---	PASS
RASAL2	9462	broad.mit.edu	37	1	178063816	178063816	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:178063816G>T	uc001glq.2	+	1	953	c.189G>T	c.(187-189)TGG>TGT	p.W63C	RASAL2_uc009wxb.2_Missense_Mutation_p.W63C|LOC100302401_uc001gln.1_5'Flank|LOC100302401_uc001glo.1_5'Flank|RASAL2_uc009wxa.2_RNA	NM_170692	NP_733793	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 2	Error:Variant_position_missing_in_Q9UJF2_after_alignment					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						AACAGAGCTGGGTCCGGGTGT	0.582													15	23	---	---	---	---	PASS
IVNS1ABP	10625	broad.mit.edu	37	1	185277948	185277948	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:185277948A>G	uc001grl.2	-	5	964	c.341T>C	c.(340-342)ATG>ACG	p.M114T	IVNS1ABP_uc001grj.2_5'Flank|IVNS1ABP_uc009wyj.2_5'UTR|IVNS1ABP_uc009wyk.2_RNA	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	114					interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						TACTCGATCCATCTTCAGCTT	0.303													25	39	---	---	---	---	PASS
CFH	3075	broad.mit.edu	37	1	196684863	196684863	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:196684863G>A	uc001gtj.3	+	11	1900	c.1660G>A	c.(1660-1662)GGT>AGT	p.G554S		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	554	Sushi 9.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						CATAGTGTGTGGTTACAATGG	0.279													8	61	---	---	---	---	PASS
CFHR5	81494	broad.mit.edu	37	1	196965332	196965332	+	Splice_Site	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:196965332G>C	uc001gts.3	+	6	1098	c.970_splice	c.e6+1	p.A324_splice		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor						complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						ATGTGTGTTGGTGAGAAAACA	0.224													5	31	---	---	---	---	PASS
ELK4	2005	broad.mit.edu	37	1	205589867	205589867	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:205589867C>A	uc001hcy.1	-	3	1557	c.307G>T	c.(307-309)GGT>TGT	p.G103C	ELK4_uc001hcz.2_Missense_Mutation_p.G103C	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	103						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TCACAGTCACCCTCAATCCTG	0.428			T	SLC45A3	prostate								16	40	---	---	---	---	PASS
CDC42BPA	8476	broad.mit.edu	37	1	227381487	227381487	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:227381487C>A	uc001hqr.2	-	5	1542	c.599G>T	c.(598-600)AGA>ATA	p.R200I	CDC42BPA_uc001hqs.2_Missense_Mutation_p.R200I|CDC42BPA_uc009xes.2_Missense_Mutation_p.R200I|CDC42BPA_uc010pvs.1_Missense_Mutation_p.R200I	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	200	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				ACTGTTTTACCTGTGTACATA	0.378													17	33	---	---	---	---	PASS
TOMM20	9804	broad.mit.edu	37	1	235291986	235291986	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:235291986G>A	uc001hwl.2	-	1	271	c.45C>T	c.(43-45)GCC>GCT	p.A15A	SNORA14B_uc001hwm.1_5'Flank	NM_014765	NP_055580	Q15388	TOM20_HUMAN	translocase of outer mitochondrial membrane 20	15	Helical; (Potential).				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|unfolded protein binding				0	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;6.33e-05)|Epithelial(3;8.26e-05)			CAATGAAAAGGGCCCCGCATA	0.607													35	76	---	---	---	---	PASS
EXO1	9156	broad.mit.edu	37	1	242035336	242035336	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:242035336G>T	uc001hzh.2	+	12	1810	c.1270G>T	c.(1270-1272)GAG>TAG	p.E424*	EXO1_uc001hzi.2_Nonsense_Mutation_p.E424*|EXO1_uc001hzj.2_Nonsense_Mutation_p.E424*|EXO1_uc009xgq.2_Splice_Site_p.E423_splice	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	424	Interaction with MLH1.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TTATTTAGCAGAGCTGTCAGA	0.333								Direct_reversal_of_damage|Editing_and_processing_nucleases					13	21	---	---	---	---	PASS
OR6F1	343169	broad.mit.edu	37	1	247875736	247875736	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr1:247875736C>A	uc001idj.1	-	1	322	c.322G>T	c.(322-324)GGC>TGC	p.G108C		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCTGTGCAGCCTAATGAGAAA	0.498													13	65	---	---	---	---	PASS
MYT1L	23040	broad.mit.edu	37	2	1842979	1842979	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:1842979G>T	uc002qxe.2	-	21	3849	c.3022C>A	c.(3022-3024)CCC>ACC	p.P1008T	MYT1L_uc002qxd.2_Missense_Mutation_p.P1006T|MYT1L_uc010ewk.2_Missense_Mutation_p.P4T	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1008	C2HC-type 6.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CCTGGCGTGGGGCAGGACATG	0.672													7	13	---	---	---	---	PASS
KIDINS220	57498	broad.mit.edu	37	2	8871217	8871217	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:8871217T>C	uc002qzc.2	-	30	5131	c.4949A>G	c.(4948-4950)AAG>AGG	p.K1650R	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.K1551R|KIDINS220_uc002qzb.2_Missense_Mutation_p.K504R	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1650	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AGGGCTTTTCTTGTCTTCTGA	0.522													16	39	---	---	---	---	PASS
ASXL2	55252	broad.mit.edu	37	2	25965124	25965124	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:25965124G>A	uc002rgs.2	-	12	4303	c.4082C>T	c.(4081-4083)TCA>TTA	p.S1361L	ASXL2_uc002rgt.1_Missense_Mutation_p.S844L	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACAGTCACTGAAAATGACAT	0.493													22	44	---	---	---	---	PASS
ZNF513	130557	broad.mit.edu	37	2	27603054	27603054	+	Silent	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:27603054T>C	uc002rkk.2	-	2	317	c.117A>G	c.(115-117)CTA>CTG	p.L39L	ZNF513_uc002rkj.2_5'UTR	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	39					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTGGCCTAGTAGCAAATCAC	0.572													49	103	---	---	---	---	PASS
ABCG8	64241	broad.mit.edu	37	2	44104801	44104801	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:44104801C>A	uc002rtq.2	+	12	1948	c.1858C>A	c.(1858-1860)CTC>ATC	p.L620I	ABCG8_uc010yoa.1_Missense_Mutation_p.L619I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	620	ABC transmembrane type-2.|Extracellular (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCTCGGGAACCTCACCATCGC	0.517											OREG0014582	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	44	---	---	---	---	PASS
TET3	200424	broad.mit.edu	37	2	74300734	74300734	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:74300734G>T	uc002skb.3	+	2	2148	c.2148G>T	c.(2146-2148)ACG>ACT	p.T716T	TET3_uc010fez.1_Silent_p.T716T	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	716							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTGGCCCCACGGTCGCCTCTA	0.438													5	10	---	---	---	---	PASS
DNAH6	1768	broad.mit.edu	37	2	84785056	84785056	+	Silent	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:84785056A>T	uc010fgb.2	+	11	1937	c.1800A>T	c.(1798-1800)ATA>ATT	p.I600I	DNAH6_uc002soo.2_Silent_p.I179I|DNAH6_uc002sop.2_Silent_p.I179I	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	600	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						TTTCTCAAATAAAGGTATGTT	0.259													11	27	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89309696	89309696	+	RNA	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:89309696C>G	uc010ytr.1	-	74		c.6651G>C			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		ACTGGCCCGGCAAGTGATGGT	0.488													60	145	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89475975	89475975	+	RNA	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:89475975C>A	uc010ytr.1	-	28		c.3506G>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		TGGAGGCTGGCCTGGCCTCTG	0.527													38	84	---	---	---	---	PASS
INPP4A	3631	broad.mit.edu	37	2	99181196	99181196	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:99181196G>T	uc002syy.2	+	20	2530	c.2137G>T	c.(2137-2139)GCC>TCC	p.A713S	INPP4A_uc010yvj.1_Missense_Mutation_p.A674S|INPP4A_uc010yvk.1_Missense_Mutation_p.A674S|INPP4A_uc002syx.2_Missense_Mutation_p.A708S|INPP4A_uc010fik.2_Intron	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	713					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						CGGGCTGCTGGCCCAGTTCGA	0.622													4	4	---	---	---	---	PASS
CNTNAP5	129684	broad.mit.edu	37	2	125521621	125521621	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:125521621G>T	uc002tno.2	+	16	2791	c.2427G>T	c.(2425-2427)GCG>GCT	p.A809A	CNTNAP5_uc010flu.2_Silent_p.A810A	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	809	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCTTCCATGCGGAATTCAGTG	0.398													21	45	---	---	---	---	PASS
MBD5	55777	broad.mit.edu	37	2	149247363	149247363	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:149247363G>T	uc002twm.3	+	12	4451	c.3463G>T	c.(3463-3465)GAT>TAT	p.D1155Y	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.D1155Y|MBD5_uc002two.2_Missense_Mutation_p.D413Y|MBD5_uc002twp.2_Missense_Mutation_p.D205Y	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1155						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TGTTGATCATGATGGTAGGCT	0.488													15	41	---	---	---	---	PASS
STAM2	10254	broad.mit.edu	37	2	152977290	152977290	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:152977290G>T	uc002tyc.3	-	14	1726	c.1376C>A	c.(1375-1377)CCT>CAT	p.P459H		NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	459					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		CATATAAGTAGGATTGGAAAC	0.358													5	57	---	---	---	---	PASS
NR4A2	4929	broad.mit.edu	37	2	157182348	157182348	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:157182348C>A	uc002tyz.3	-	8	2127	c.1705G>T	c.(1705-1707)GGG>TGG	p.G569W	NR4A2_uc002tyx.3_Missense_Mutation_p.G506W|NR4A2_uc010zcf.1_Missense_Mutation_p.G569W	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	569					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						CGCTGTAGCCCCTGTGTGCAA	0.478													17	48	---	---	---	---	PASS
SCN1A	6323	broad.mit.edu	37	2	166897952	166897952	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:166897952G>A	uc010zcz.1	-	13	2189	c.2171C>T	c.(2170-2172)CCA>CTA	p.P724L	SCN1A_uc002udo.3_Missense_Mutation_p.P604L|SCN1A_uc010fpk.2_Missense_Mutation_p.P576L	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	735						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCAACAGGGTGGGCATTTCTG	0.348													17	47	---	---	---	---	PASS
XIRP2	129446	broad.mit.edu	37	2	167760268	167760268	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:167760268G>T	uc002udx.2	+	1	294	c.276G>T	c.(274-276)CGG>CGT	p.R92R	XIRP2_uc010fpn.2_Silent_p.R92R|XIRP2_uc010fpo.2_Silent_p.R92R|XIRP2_uc010fpp.2_Silent_p.R92R	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AATATGGTCGGCCAGAAGTGC	0.522													20	28	---	---	---	---	PASS
XIRP2	129446	broad.mit.edu	37	2	168103133	168103133	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:168103133A>T	uc002udx.2	+	8	5249	c.5231A>T	c.(5230-5232)CAG>CTG	p.Q1744L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.Q1569L|XIRP2_uc010fpq.2_Missense_Mutation_p.Q1522L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1569					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GGAAATGTTCAGTTTTTCACA	0.378													17	21	---	---	---	---	PASS
XIRP2	129446	broad.mit.edu	37	2	168106057	168106057	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:168106057G>C	uc002udx.2	+	8	8173	c.8155G>C	c.(8155-8157)GAT>CAT	p.D2719H	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.D2544H|XIRP2_uc010fpq.2_Missense_Mutation_p.D2497H|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.D65H	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2544					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCCAACTCTAGATCATACATT	0.348													17	83	---	---	---	---	PASS
LRP2	4036	broad.mit.edu	37	2	170042267	170042267	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:170042267G>A	uc002ues.2	-	50	9804	c.9591C>T	c.(9589-9591)ATC>ATT	p.I3197I		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3197	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GATAGGGTTCGATGTTACTGT	0.438													36	116	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179636118	179636118	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:179636118G>A	uc010zfg.1	-	34	8160	c.7936C>T	c.(7936-7938)CCA>TCA	p.P2646S	TTN_uc010zfh.1_Missense_Mutation_p.P2600S|TTN_uc010zfi.1_Missense_Mutation_p.P2600S|TTN_uc010zfj.1_Missense_Mutation_p.P2600S|TTN_uc002unb.2_Missense_Mutation_p.P2646S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2646							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGAATCTGGGTTGGCAACT	0.483													15	28	---	---	---	---	PASS
NDUFS1	4719	broad.mit.edu	37	2	207008770	207008770	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:207008770T>A	uc002vbe.2	-	10	1086	c.959A>T	c.(958-960)GAG>GTG	p.E320V	NDUFS1_uc010ziq.1_Missense_Mutation_p.E334V|NDUFS1_uc010zir.1_Missense_Mutation_p.E284V|NDUFS1_uc010zis.1_Missense_Mutation_p.E263V|NDUFS1_uc010zit.1_Missense_Mutation_p.E209V|NDUFS1_uc010ziu.1_Missense_Mutation_p.E204V	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	320					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	GAGCGCATCCTCCCAAGAAGT	0.393													25	23	---	---	---	---	PASS
IQCA1	79781	broad.mit.edu	37	2	237300976	237300976	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:237300976C>A	uc002vvz.1	-	10	1410	c.1228G>T	c.(1228-1230)GAT>TAT	p.D410Y	IQCA1_uc002vwb.2_Missense_Mutation_p.D417Y|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.D369Y	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	410	Lys-rich.						ATP binding			ovary(1)	1						CAAGACTCATCTTTTTTCATC	0.333													3	6	---	---	---	---	PASS
C2orf85	285093	broad.mit.edu	37	2	242814655	242814655	+	Silent	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr2:242814655C>G	uc010fzu.1	+	2	971	c.948C>G	c.(946-948)GTC>GTG	p.V316V		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	316						integral to membrane				ovary(1)	1						ATGGCCTCGTCCCTGTGGGGA	0.657													7	12	---	---	---	---	PASS
CACNA2D2	9254	broad.mit.edu	37	3	50402790	50402790	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:50402790G>A	uc003daq.2	-	36	3154	c.3116C>T	c.(3115-3117)TCC>TTC	p.S1039F	CACNA2D2_uc003dap.2_Missense_Mutation_p.S1032F|CACNA2D2_uc003dao.2_Silent_p.L77L	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha	1039	Extracellular (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	CCAGCACCTGGAGCAGTTTCC	0.562													9	9	---	---	---	---	PASS
CADPS	8618	broad.mit.edu	37	3	62522231	62522231	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:62522231G>A	uc003dll.2	-	12	2352	c.1992C>T	c.(1990-1992)GGC>GGT	p.G664G	CADPS_uc003dlk.1_Silent_p.G168G|CADPS_uc003dlm.2_Silent_p.G664G|CADPS_uc003dln.2_Silent_p.G664G	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	664					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ATTCATCCATGCCATGTTTTT	0.383													21	33	---	---	---	---	PASS
ABI3BP	25890	broad.mit.edu	37	3	100594368	100594368	+	Silent	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:100594368C>G	uc003dun.2	-	8	907	c.822G>C	c.(820-822)CTG>CTC	p.L274L	ABI3BP_uc003duo.2_Silent_p.L267L|ABI3BP_uc003dup.3_Silent_p.L267L	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	274						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TCACTCCTCCCAGTGGAGCTT	0.438													12	62	---	---	---	---	PASS
MYH15	22989	broad.mit.edu	37	3	108211976	108211976	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:108211976C>G	uc003dxa.1	-	9	877	c.820G>C	c.(820-822)GTG>CTG	p.V274L		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	274	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TCAATGTCCACAGATGACAGC	0.318													4	60	---	---	---	---	PASS
MORC1	27136	broad.mit.edu	37	3	108724127	108724127	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:108724127G>A	uc003dxl.2	-	19	1890	c.1803C>T	c.(1801-1803)GGC>GGT	p.G601G	MORC1_uc011bhn.1_Silent_p.G580G	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	601					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TCAAGTCATCGCCCAAAAGCC	0.353													7	56	---	---	---	---	PASS
RABL3	285282	broad.mit.edu	37	3	120408716	120408716	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:120408716C>T	uc003edx.2	-	8	695	c.665G>A	c.(664-666)CGG>CAG	p.R222Q		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	222	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		AAATCTTTTCCGATCAGGAAA	0.378													11	100	---	---	---	---	PASS
EEFSEC	60678	broad.mit.edu	37	3	127965812	127965812	+	Silent	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:127965812C>G	uc003eki.2	+	2	488	c.450C>G	c.(448-450)CTC>CTG	p.L150L	EEFSEC_uc003ekj.2_Silent_p.L150L	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	150	GTP (Potential).					cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						AAATAGACCTCTTACCTGAAG	0.483													86	253	---	---	---	---	PASS
AGTR1	185	broad.mit.edu	37	3	148459456	148459456	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:148459456C>A	uc003ewg.2	+	4	1080	c.634C>A	c.(634-636)CTT>ATT	p.L212I	AGTR1_uc003ewh.2_Missense_Mutation_p.L212I|AGTR1_uc003ewi.2_Missense_Mutation_p.L212I|AGTR1_uc003ewj.2_Missense_Mutation_p.L212I|AGTR1_uc003ewk.2_Missense_Mutation_p.L212I	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	212	Helical; Name=5; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TCTGATCATTCTTACAAGTTA	0.363													8	56	---	---	---	---	PASS
IGSF10	285313	broad.mit.edu	37	3	151164451	151164451	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:151164451G>T	uc011bod.1	-	4	3318	c.3318C>A	c.(3316-3318)GTC>GTA	p.V1106V		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1106					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGGATTCTGGACTAGAGTTG	0.443													31	184	---	---	---	---	PASS
GPR149	344758	broad.mit.edu	37	3	154055904	154055904	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:154055904A>T	uc003faa.2	-	4	1880	c.1780T>A	c.(1780-1782)TCC>ACC	p.S594T		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	594	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			ACACTTTTGGATCGATAGACT	0.413													10	177	---	---	---	---	PASS
PLCH1	23007	broad.mit.edu	37	3	155203419	155203419	+	Silent	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:155203419T>C	uc011bok.1	-	22	3001	c.2724A>G	c.(2722-2724)GTA>GTG	p.V908V	PLCH1_uc011boj.1_Silent_p.V908V|PLCH1_uc011bol.1_Silent_p.V870V	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	908					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			ATCGCTTCCGTACATAATGGG	0.463													38	23	---	---	---	---	PASS
SI	6476	broad.mit.edu	37	3	164709160	164709160	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:164709160C>A	uc003fei.2	-	44	5151	c.5089G>T	c.(5089-5091)GCT>TCT	p.A1697S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1697	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTGTTTTGAGCTGGCTCTTGA	0.333										HNSCC(35;0.089)			18	77	---	---	---	---	PASS
PLD1	5337	broad.mit.edu	37	3	171320967	171320967	+	Silent	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:171320967T>C	uc003fhs.2	-	27	3242	c.3126A>G	c.(3124-3126)GGA>GGG	p.G1042G	PLD1_uc003fht.2_Silent_p.G1004G	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	1042					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GCACCAAAAATCCACGGATCT	0.433													18	63	---	---	---	---	PASS
NDUFB5	4711	broad.mit.edu	37	3	179322629	179322629	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:179322629G>C	uc003fkc.2	+	1	55	c.26G>C	c.(25-27)CGG>CCG	p.R9P	MRPL47_uc003fjz.2_5'Flank|MRPL47_uc003fka.2_5'Flank|MRPL47_uc003fkb.2_5'Flank|NDUFB5_uc003fkd.2_RNA|NDUFB5_uc003fke.2_Missense_Mutation_p.R9P	NM_002492	NP_002483	O43674	NDUB5_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	9					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			skin(1)	1	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)		NADH(DB00157)	TTGTTGCGGCGGGTTTCGGTT	0.607													22	36	---	---	---	---	PASS
IGF2BP2	10644	broad.mit.edu	37	3	185407290	185407290	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:185407290C>T	uc003fpo.2	-	6	609	c.530G>A	c.(529-531)CGG>CAG	p.R177Q	IGF2BP2_uc010hyi.2_Missense_Mutation_p.R120Q|IGF2BP2_uc010hyj.2_Missense_Mutation_p.R114Q|IGF2BP2_uc010hyk.2_Missense_Mutation_p.R41Q|IGF2BP2_uc010hyl.2_Missense_Mutation_p.R114Q|IGF2BP2_uc003fpp.2_Missense_Mutation_p.R177Q|IGF2BP2_uc003fpq.2_Missense_Mutation_p.R182Q	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	177					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			GCCTTGCTCCCGGGAAGAGTG	0.602													13	107	---	---	---	---	PASS
ATP13A3	79572	broad.mit.edu	37	3	194167745	194167745	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:194167745G>C	uc003fty.3	-	13	1810	c.1408C>G	c.(1408-1410)CAG>GAG	p.Q470E	ATP13A3_uc003ftz.1_Missense_Mutation_p.Q176E	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	470					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AGTCTTCTCTGAGCATACACA	0.403													7	108	---	---	---	---	PASS
BDH1	622	broad.mit.edu	37	3	197260416	197260416	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:197260416C>A	uc003fxr.2	-	4	502	c.100G>T	c.(100-102)GGT>TGT	p.G34C	BDH1_uc003fxs.2_Missense_Mutation_p.G34C|BDH1_uc003fxt.2_5'UTR|BDH1_uc003fxu.2_Missense_Mutation_p.G34C	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	34					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	GAAGTAGAACCAAGCAATAGT	0.572													6	145	---	---	---	---	PASS
EVC2	132884	broad.mit.edu	37	4	5687126	5687126	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:5687126C>A	uc003gij.2	-	6	841	c.787G>T	c.(787-789)GCC>TCC	p.A263S	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.A183S	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	263						integral to membrane				large_intestine(3)|ovary(2)	5						GTGAGTTGGGCAGGAAGCTTG	0.527													73	52	---	---	---	---	PASS
BST1	683	broad.mit.edu	37	4	15716916	15716916	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:15716916G>T	uc003goh.3	+	5	738	c.543G>T	c.(541-543)AAG>AAT	p.K181N	BST1_uc003goi.2_Translation_Start_Site	NM_004334	NP_004325	Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1 precursor	181					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)	1						AGTATTCCAAGGATAGTTCTG	0.323													4	27	---	---	---	---	PASS
PCDH10	57575	broad.mit.edu	37	4	134072866	134072866	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:134072866A>G	uc003iha.2	+	1	2397	c.1571A>G	c.(1570-1572)TAC>TGC	p.Y524C	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.Y524C	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	524	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GAGAACGGCTACTTGTACGCC	0.587													9	39	---	---	---	---	PASS
TBC1D9	23158	broad.mit.edu	37	4	141600878	141600878	+	Silent	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:141600878G>C	uc010ioj.2	-	4	752	c.480C>G	c.(478-480)CTC>CTG	p.L160L		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	160	GRAM 1.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				AATAGTTGACGAGTTTCTCTT	0.418													6	26	---	---	---	---	PASS
RNF150	57484	broad.mit.edu	37	4	141888789	141888789	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:141888789C>G	uc003iio.1	-	2	1377	c.723G>C	c.(721-723)AGG>AGC	p.R241S	RNF150_uc010iok.1_Intron|RNF150_uc003iip.1_Missense_Mutation_p.R241S	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	241	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					GGTTCCTATCCCTGGCATTTG	0.368													14	38	---	---	---	---	PASS
HHIP	64399	broad.mit.edu	37	4	145655962	145655962	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:145655962G>T	uc003ijs.1	+	12	2485	c.1830G>T	c.(1828-1830)AGG>AGT	p.R610S		NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	610	EGF-like 1.					cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		AGTGCTCCAGGCTCTGTCGAA	0.502													11	28	---	---	---	---	PASS
ABCE1	6059	broad.mit.edu	37	4	146026771	146026771	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:146026771G>C	uc003ijx.2	+	3	558	c.118G>C	c.(118-120)GAG>CAG	p.E40Q	ABCE1_uc003ijy.2_Missense_Mutation_p.E40Q|ABCE1_uc010iot.2_RNA	NM_001040876	NP_001035809	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E, member 1	40					interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			skin(1)	1	all_hematologic(180;0.151)					ATTATGCATAGAGGTTACACC	0.328													13	36	---	---	---	---	PASS
KIAA0922	23240	broad.mit.edu	37	4	154512253	154512253	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:154512253G>T	uc003inm.3	+	17	1768	c.1716G>T	c.(1714-1716)AAG>AAT	p.K572N	KIAA0922_uc010ipp.2_Missense_Mutation_p.K573N|KIAA0922_uc010ipq.2_Intron	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	572	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				AGAAATCCAAGGAGTCAGAGT	0.378													5	73	---	---	---	---	PASS
TDO2	6999	broad.mit.edu	37	4	156831260	156831260	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:156831260G>C	uc003ipf.1	+	6	579	c.515G>C	c.(514-516)AGA>ACA	p.R172T		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	172					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	CAGAACATGAGAGTCCCTTAT	0.373													9	39	---	---	---	---	PASS
DDX60L	91351	broad.mit.edu	37	4	169342912	169342912	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr4:169342912T>A	uc003irq.3	-	17	2614	c.2393A>T	c.(2392-2394)AAG>ATG	p.K798M	DDX60L_uc003irr.1_Missense_Mutation_p.K798M|DDX60L_uc003irs.1_Missense_Mutation_p.K525M	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	798	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		AAACACTACCTTTGCGGGTGC	0.453													36	76	---	---	---	---	PASS
SDHA	6389	broad.mit.edu	37	5	226069	226069	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:226069G>C	uc003jao.3	+	5	643	c.528G>C	c.(526-528)CAG>CAC	p.Q176H	SDHA_uc003jan.2_Missense_Mutation_p.Q176H|SDHA_uc011clv.1_Missense_Mutation_p.Q176H|SDHA_uc011clw.1_Missense_Mutation_p.Q128H|SDHA_uc003jap.3_Missense_Mutation_p.Q176H|SDHA_uc003jaq.3_5'Flank	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	176					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TTGGTGGACAGAGCCTCAAGT	0.483									Familial_Paragangliomas				7	149	---	---	---	---	PASS
SLC6A3	6531	broad.mit.edu	37	5	1432761	1432761	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:1432761G>A	uc003jck.2	-	4	592	c.471C>T	c.(469-471)AAC>AAT	p.N157N		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	157	Helical; Name=3; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	CGATGATGACGTTGTAGAAGA	0.597													22	46	---	---	---	---	PASS
SEMA5A	9037	broad.mit.edu	37	5	9154614	9154614	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:9154614G>A	uc003jek.2	-	12	2179	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	489	Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GTGTGCGGTAGAACTGGCACC	0.627													12	60	---	---	---	---	PASS
PRLR	5618	broad.mit.edu	37	5	35086375	35086375	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:35086375G>T	uc003jjm.2	-	4	668	c.138C>A	c.(136-138)TGC>TGA	p.C46*	PRLR_uc003jjg.1_Nonsense_Mutation_p.C46*|PRLR_uc003jjh.1_Nonsense_Mutation_p.C46*|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Nonsense_Mutation_p.C46*|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_Translation_Start_Site	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	46	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GCCTCCACCAGCAGGTGAATG	0.458													49	60	---	---	---	---	PASS
HTR1A	3350	broad.mit.edu	37	5	63256881	63256881	+	Silent	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:63256881C>G	uc011cqt.1	-	1	666	c.666G>C	c.(664-666)GCG>GCC	p.A222A		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	222	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGCGGAAGCGCGCAGCTCGGA	0.562													33	51	---	---	---	---	PASS
BDP1	55814	broad.mit.edu	37	5	70840961	70840961	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:70840961A>T	uc003kbp.1	+	32	6922	c.6659A>T	c.(6658-6660)GAT>GTT	p.D2220V	BDP1_uc003kbo.2_Missense_Mutation_p.D2220V|BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2220					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CTTGGTTTGGATAGGGGTCTT	0.463													18	60	---	---	---	---	PASS
CAMK4	814	broad.mit.edu	37	5	110809012	110809012	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:110809012C>A	uc011cvj.1	+	9	728	c.629C>A	c.(628-630)CCT>CAT	p.P210H	CAMK4_uc003kpf.2_Missense_Mutation_p.P210H|CAMK4_uc010jbv.2_Missense_Mutation_p.P13H	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	210	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TCTGCAGCACCTGAAATTCTT	0.318													5	69	---	---	---	---	PASS
APC	324	broad.mit.edu	37	5	112173893	112173893	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:112173893G>C	uc010jby.2	+	16	2982	c.2602G>C	c.(2602-2604)GAA>CAA	p.E868Q	APC_uc011cvt.1_Missense_Mutation_p.E850Q|APC_uc003kpz.3_Missense_Mutation_p.E868Q|APC_uc003kpy.3_Missense_Mutation_p.E868Q|APC_uc010jbz.2_Missense_Mutation_p.E585Q|APC_uc010jca.2_Missense_Mutation_p.E168Q	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	868	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E868*(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCCAGCAACAGAAAATCCAGG	0.453		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			25	23	---	---	---	---	PASS
DMXL1	1657	broad.mit.edu	37	5	118484909	118484909	+	Silent	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:118484909A>G	uc003ksd.2	+	18	3568	c.3387A>G	c.(3385-3387)AAA>AAG	p.K1129K	DMXL1_uc010jcl.1_Silent_p.K1129K	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1129										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TATCTAGTAAAGAGAATATCA	0.333													10	53	---	---	---	---	PASS
TCF7	6932	broad.mit.edu	37	5	133478442	133478442	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:133478442G>T	uc003kyt.2	+	7	982	c.786G>T	c.(784-786)AAG>AAT	p.K262N	TCF7_uc003kyu.1_Missense_Mutation_p.K147N|TCF7_uc003kyv.2_Missense_Mutation_p.K147N|TCF7_uc003kyw.2_Missense_Mutation_p.K147N|TCF7_uc003kyx.2_Missense_Mutation_p.K60N|TCF7_uc003kyy.2_Missense_Mutation_p.K147N|TCF7_uc003kyz.2_Missense_Mutation_p.K147N|TCF7_uc003kza.2_Missense_Mutation_p.K147N|TCF7_uc003kzb.2_Missense_Mutation_p.K76N|TCF7_uc010jdu.2_5'Flank	NM_003202	NP_003193	P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific,	262					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding				0		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGCAGAGAAGGAGGCCAAGA	0.532													5	67	---	---	---	---	PASS
CATSPER3	347732	broad.mit.edu	37	5	134305628	134305628	+	Splice_Site	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:134305628G>T	uc003lag.2	+	2	167	c.99_splice	c.e2-1	p.K33_splice		NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTTTTTGACAGGAGGAACGAT	0.393													5	71	---	---	---	---	PASS
KDM3B	51780	broad.mit.edu	37	5	137762958	137762958	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:137762958C>G	uc003lcy.1	+	19	4783	c.4583C>G	c.(4582-4584)CCT>CGT	p.P1528R	KDM3B_uc010jew.1_Missense_Mutation_p.P1184R|KDM3B_uc011cys.1_Missense_Mutation_p.P560R	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1528	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						TCTAGGCTACCTAGCTACTTT	0.463													24	41	---	---	---	---	PASS
PCDHB6	56130	broad.mit.edu	37	5	140531962	140531962	+	Silent	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:140531962G>C	uc003lir.2	+	1	2124	c.2124G>C	c.(2122-2124)GCG>GCC	p.A708A	PCDHB6_uc011dah.1_Silent_p.A572A	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	708	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTCGTGGCGGTGCGGCTGT	0.682													16	57	---	---	---	---	PASS
PCDHGA5	56110	broad.mit.edu	37	5	140744848	140744848	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:140744848G>T	uc003lju.1	+	1	951	c.951G>T	c.(949-951)ATG>ATT	p.M317I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.M317I	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	317	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTACCTCATGGAAGTGGTAG	0.478													10	18	---	---	---	---	PASS
PCDHGA6	56109	broad.mit.edu	37	5	140756055	140756055	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:140756055G>T	uc003ljy.1	+	1	2405	c.2405G>T	c.(2404-2406)GGA>GTA	p.G802V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.G802V	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	802	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACGAAAGGAGAACCCAGG	0.478													21	38	---	---	---	---	PASS
PCDHGA6	56109	broad.mit.edu	37	5	140756056	140756056	+	Silent	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:140756056A>T	uc003ljy.1	+	1	2406	c.2406A>T	c.(2404-2406)GGA>GGT	p.G802G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.G802G	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	802	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAACGAAAGGAGAACCCAGGC	0.483													21	38	---	---	---	---	PASS
PCDHGB4	8641	broad.mit.edu	37	5	140769650	140769650	+	Silent	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:140769650C>T	uc003lkc.1	+	1	2199	c.2199C>T	c.(2197-2199)TCC>TCT	p.S733S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Silent_p.S733S	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	733	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGTTAAATCCGAATCCGTGG	0.527													45	114	---	---	---	---	PASS
PCDHGA10	56106	broad.mit.edu	37	5	140794536	140794536	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:140794536G>A	uc003lkl.1	+	1	1794	c.1794G>A	c.(1792-1794)GTG>GTA	p.V598V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.V598V|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	598	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGGCGGTGGACAGAGACT	0.697													13	60	---	---	---	---	PASS
HAVCR2	84868	broad.mit.edu	37	5	156533930	156533930	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr5:156533930G>A	uc003lwk.1	-	2	246	c.102C>T	c.(100-102)GCC>GCT	p.A34A	HAVCR2_uc003lwl.2_Silent_p.A34A	NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	34	Ig-like V-type.|Extracellular (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGGCAGATAGGCATTCTGAC	0.572													17	68	---	---	---	---	PASS
KIF13A	63971	broad.mit.edu	37	6	17781053	17781053	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:17781053G>T	uc003ncg.3	-	31	3859	c.3754C>A	c.(3754-3756)CTA>ATA	p.L1252I	KIF13A_uc003ncf.2_Missense_Mutation_p.L1239I|KIF13A_uc003nch.3_Missense_Mutation_p.L1252I|KIF13A_uc003nci.3_Missense_Mutation_p.L1239I|KIF13A_uc003nce.1_5'Flank	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	1252					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTCACAATTAGGTAAATCCTT	0.428													6	82	---	---	---	---	PASS
KIF13A	63971	broad.mit.edu	37	6	17817326	17817326	+	Missense_Mutation	SNP	T	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:17817326T>G	uc003ncg.3	-	17	2030	c.1925A>C	c.(1924-1926)CAG>CCG	p.Q642P	KIF13A_uc003ncf.2_Missense_Mutation_p.Q642P|KIF13A_uc003nch.3_Missense_Mutation_p.Q642P|KIF13A_uc003nci.3_Missense_Mutation_p.Q642P|KIF13A_uc003ncj.2_Missense_Mutation_p.Q318P	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	642	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GCCGCTACTCTGTGGCTGCCT	0.622													6	10	---	---	---	---	PASS
CDKAL1	54901	broad.mit.edu	37	6	20955674	20955674	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:20955674C>G	uc003ndc.1	+	10	941	c.767C>G	c.(766-768)ACC>AGC	p.T256S	CDKAL1_uc003ndd.1_Missense_Mutation_p.T256S|CDKAL1_uc003nde.1_Missense_Mutation_p.T186S	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	256					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			ATATGGTTGACCAGTGAAGAC	0.458													42	25	---	---	---	---	PASS
GPLD1	2822	broad.mit.edu	37	6	24476472	24476472	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:24476472C>A	uc003ned.1	-	4	378	c.267G>T	c.(265-267)TGG>TGT	p.W89C	GPLD1_uc010jpr.1_5'UTR|GPLD1_uc010jps.1_Missense_Mutation_p.W89C|GPLD1_uc003nee.2_Missense_Mutation_p.W89C	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	89						extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						GAAACGGAGTCCAGTGAGTGC	0.433													5	6	---	---	---	---	PASS
HIST1H2BJ	8970	broad.mit.edu	37	6	27100230	27100230	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:27100230G>A	uc003niv.2	-	1	346	c.300C>T	c.(298-300)CGC>CGT	p.R100R	HIST1H2BJ_uc003niu.1_Intron|HIST1H2AG_uc003niw.2_5'Flank	NM_021058	NP_066402	P06899	H2B1J_HUMAN	histone cluster 1, H2bj	100					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCAGCAGCAGGCGCACGGCCG	0.592													52	35	---	---	---	---	PASS
C6orf222	389384	broad.mit.edu	37	6	36298332	36298332	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:36298332T>C	uc003oly.2	-	2	314	c.136A>G	c.(136-138)AAG>GAG	p.K46E		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	46										skin(2)|ovary(1)|breast(1)	4						TGAAGCGCCTTCCTGGAGGGG	0.652													37	21	---	---	---	---	PASS
PRIM2	5558	broad.mit.edu	37	6	57512691	57512691	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:57512691G>T	uc003pdx.2	+	15	1606	c.1519G>T	c.(1519-1521)GAA>TAA	p.E507*		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	507					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TTACTTTAGTGAAGATTCTTA	0.333													39	229	---	---	---	---	PASS
FUT9	10690	broad.mit.edu	37	6	96651734	96651734	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:96651734A>G	uc003pop.3	+	3	1044	c.703A>G	c.(703-705)ATA>GTA	p.I235V		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	235	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GATTCCTACCATATCTACTTG	0.353													6	26	---	---	---	---	PASS
LAMA4	3910	broad.mit.edu	37	6	112452259	112452259	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:112452259C>T	uc003pvu.2	-	29	4188	c.3879G>A	c.(3877-3879)ATG>ATA	p.M1293I	LAMA4_uc003pvv.2_Missense_Mutation_p.M1286I|LAMA4_uc003pvt.2_Missense_Mutation_p.M1286I	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1293	Laminin G-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding	p.M1286I(1)		ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CCTTTACATCCATGATGACAG	0.453													17	64	---	---	---	---	PASS
VNN2	8875	broad.mit.edu	37	6	133065475	133065475	+	Silent	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:133065475T>C	uc003qdt.2	-	7	1538	c.1527A>G	c.(1525-1527)TTA>TTG	p.L509L	VNN2_uc003qds.2_Silent_p.L218L|VNN2_uc010kgb.2_Silent_p.L288L|VNN2_uc003qdv.2_Silent_p.L456L	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	509					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CTATGATCATTAATAATATGA	0.398													13	94	---	---	---	---	PASS
ICA1	3382	broad.mit.edu	37	7	8167536	8167536	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:8167536G>T	uc003srm.2	-	13	1364	c.1297C>A	c.(1297-1299)CAA>AAA	p.Q433K	ICA1_uc010ktr.2_Missense_Mutation_p.Q462K|ICA1_uc003srl.2_Missense_Mutation_p.Q421K|ICA1_uc003srn.3_Missense_Mutation_p.Q359K|ICA1_uc003srp.3_Missense_Mutation_p.Q432K|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Missense_Mutation_p.Q433K|ICA1_uc003srr.2_Missense_Mutation_p.Q432K|ICA1_uc003sro.3_Missense_Mutation_p.Q433K	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	433					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		TTCATATTTTGGTCTAAAAGC	0.488													7	157	---	---	---	---	PASS
ABCB5	340273	broad.mit.edu	37	7	20682900	20682900	+	Silent	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:20682900C>A	uc010kuh.2	+	6	645	c.408C>A	c.(406-408)ACC>ACA	p.T136T		NM_001163941	NP_001157413	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	320	Extracellular (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CACGACAGACCAAGAGGATTC	0.423													5	23	---	---	---	---	PASS
HIBADH	11112	broad.mit.edu	37	7	27582650	27582650	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:27582650G>T	uc003szf.2	-	5	749	c.554C>A	c.(553-555)GCC>GAC	p.A185D	HIBADH_uc003szg.2_Missense_Mutation_p.A136D|HIBADH_uc003szh.2_Missense_Mutation_p.A84D|HIBADH_uc003szi.2_Missense_Mutation_p.A136D	NM_152740	NP_689953	P31937	3HIDH_HUMAN	3-hydroxyisobutyrate dehydrogenase precursor	185					branched chain family amino acid catabolic process|pentose-phosphate shunt|valine metabolic process	mitochondrial matrix	3-hydroxyisobutyrate dehydrogenase activity|NAD binding|phosphogluconate dehydrogenase (decarboxylating) activity			ovary(2)	2			GBM - Glioblastoma multiforme(3;0.0368)		NADH(DB00157)	CAACTCTTGGGCAGCAGCAAA	0.493													11	38	---	---	---	---	PASS
TBX20	57057	broad.mit.edu	37	7	35289604	35289604	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:35289604G>T	uc011kas.1	-	2	350	c.339C>A	c.(337-339)TTC>TTA	p.F113L		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	113	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						CCAGCTCATGGAATTTGTCCC	0.582													11	29	---	---	---	---	PASS
POU6F2	11281	broad.mit.edu	37	7	39446339	39446339	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:39446339G>T	uc003thb.1	+	6	1068	c.1026G>T	c.(1024-1026)CAG>CAT	p.Q342H		NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	342	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CACAAGGACAGGTGAGTGGGA	0.468													15	51	---	---	---	---	PASS
PKD1L1	168507	broad.mit.edu	37	7	47968883	47968883	+	Silent	SNP	G	A	A	rs142684649		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:47968883G>A	uc003tny.1	-	7	978	c.978C>T	c.(976-978)TTC>TTT	p.F326F		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	326	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AACTGTCCCCGAAATCCATCA	0.512													63	140	---	---	---	---	PASS
ANKIB1	54467	broad.mit.edu	37	7	91974291	91974291	+	Splice_Site	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:91974291G>A	uc003ulw.2	+	7	1373	c.997_splice	c.e7-1	p.C333_splice		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1								protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTCATCTCCAGTGTGACATTT	0.353													52	153	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100675507	100675507	+	Silent	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:100675507T>A	uc003uxp.1	+	3	863	c.810T>A	c.(808-810)CCT>CCA	p.P270P	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	270	Extracellular (Potential).|59 X approximate tandem repeats.|2.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACTCAGCTCCTAGTGGAGGAA	0.507													60	123	---	---	---	---	PASS
LHFPL3	375612	broad.mit.edu	37	7	103969486	103969486	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:103969486G>T	uc003vce.2	+	1	383	c.259G>T	c.(259-261)GAG>TAG	p.E87*	LHFPL3_uc003vcf.2_Nonsense_Mutation_p.E87*	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	73						integral to membrane					0						CTTCTCCCGGGAGCTGACCTG	0.617													4	21	---	---	---	---	PASS
RINT1	60561	broad.mit.edu	37	7	105204355	105204355	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:105204355G>T	uc003vda.1	+	12	2078	c.1847G>T	c.(1846-1848)AGA>ATA	p.R616I	RINT1_uc010ljj.1_Missense_Mutation_p.R191I	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	616	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						CACGTTTTTAGAGAAGTTAAA	0.368													5	43	---	---	---	---	PASS
LAMB4	22798	broad.mit.edu	37	7	107688550	107688550	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:107688550C>G	uc010ljo.1	-	28	4213	c.4129G>C	c.(4129-4131)GGA>CGA	p.G1377R	LAMB4_uc003vey.2_Missense_Mutation_p.G1377R|LAMB4_uc010ljp.1_Missense_Mutation_p.G346R	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1377	Domain alpha.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CCTGGATCTCCGCACACCTTG	0.433													10	30	---	---	---	---	PASS
OR2A25	392138	broad.mit.edu	37	7	143771754	143771754	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr7:143771754T>C	uc011ktx.1	+	1	442	c.442T>C	c.(442-444)TGG>CGG	p.W148R		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	148	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					ATTGACTTCCTGGATTTTAGG	0.458													30	67	---	---	---	---	PASS
INTS9	55756	broad.mit.edu	37	8	28695255	28695255	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:28695255G>T	uc003xha.2	-	5	599	c.300C>A	c.(298-300)CTC>CTA	p.L100L	INTS9_uc011lav.1_Silent_p.L76L|INTS9_uc011law.1_Silent_p.L79L|INTS9_uc011lax.1_5'UTR|INTS9_uc010lvc.2_RNA|INTS9_uc003xhb.2_Silent_p.L100L	NM_018250	NP_060720	Q9NV88	INT9_HUMAN	integrator complex subunit 9 isoform 1	100					snRNA processing	integrator complex	protein binding			central_nervous_system(1)|pancreas(1)	2		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		AGTTAGAGATGAGAATCACAT	0.468													4	35	---	---	---	---	PASS
RAB11FIP1	80223	broad.mit.edu	37	8	37734976	37734976	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:37734976G>T	uc003xkm.1	-	2	509	c.465C>A	c.(463-465)GCC>GCA	p.A155A	RAB11FIP1_uc010lvz.1_Silent_p.A3A|RAB11FIP1_uc003xkn.1_Silent_p.A155A|RAB11FIP1_uc003xkp.1_Silent_p.A3A	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	155					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CAAACATGCTGGCAGTCATGT	0.438													8	190	---	---	---	---	PASS
ADAM18	8749	broad.mit.edu	37	8	39502981	39502981	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:39502981A>T	uc003xni.2	+	11	1034	c.1034A>T	c.(1033-1035)AAT>ATT	p.N345I	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.N321I	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	345	Peptidase M12B.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TGCATCATGAATCATGAAGCA	0.303													26	16	---	---	---	---	PASS
CHRNA6	8973	broad.mit.edu	37	8	42608341	42608341	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:42608341C>G	uc003xpj.2	-	6	1512	c.1466G>C	c.(1465-1467)GGG>GCG	p.G489A	CHRNA6_uc011lcw.1_Missense_Mutation_p.G474A	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	489						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TCCTGTGTTCCCAAGTAGTGG	0.383													18	188	---	---	---	---	PASS
FNTA	2339	broad.mit.edu	37	8	42924714	42924714	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:42924714C>G	uc003xps.2	+	4	466	c.418C>G	c.(418-420)CTT>GTT	p.L140V	FNTA_uc003xpt.2_Missense_Mutation_p.L49V|FNTA_uc003xpu.2_Missense_Mutation_p.L73V|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	140	PFTA 1.				cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CCGGAGAGTTCTTTTGAAGTC	0.373													13	92	---	---	---	---	PASS
PI15	51050	broad.mit.edu	37	8	75757649	75757649	+	Silent	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:75757649C>T	uc003yal.2	+	5	737	c.558C>T	c.(556-558)TGC>TGT	p.C186C	uc003yak.1_Intron|PI15_uc003yam.2_Silent_p.C186C	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	186						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GGATAGGATGCGCAATTCATA	0.428													9	34	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77618662	77618662	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:77618662G>C	uc003yav.2	+	2	2726	c.2339G>C	c.(2338-2340)AGG>ACG	p.R780T	ZFHX4_uc003yat.1_Missense_Mutation_p.R780T|ZFHX4_uc003yau.1_Missense_Mutation_p.R780T|ZFHX4_uc003yaw.1_Missense_Mutation_p.R780T	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	780	C2H2-type 4; degenerate.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATGTCGCCAGGAACCTCCGA	0.493										HNSCC(33;0.089)			13	16	---	---	---	---	PASS
PKHD1L1	93035	broad.mit.edu	37	8	110457075	110457075	+	Silent	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:110457075A>G	uc003yne.2	+	38	5081	c.4977A>G	c.(4975-4977)CCA>CCG	p.P1659P		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1659	IPT/TIG 9.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TACTTTTGCCAAACATTGACC	0.433										HNSCC(38;0.096)			18	86	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139268978	139268978	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr8:139268978C>G	uc003yuy.2	-	5	493	c.322G>C	c.(322-324)GAT>CAT	p.D108H	FAM135B_uc003yux.2_Missense_Mutation_p.D9H|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	108										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGTTGAAAATCTACTTCACTC	0.433										HNSCC(54;0.14)			3	19	---	---	---	---	PASS
TLN1	7094	broad.mit.edu	37	9	35710609	35710609	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:35710609G>T	uc003zxt.2	-	33	4629	c.4275C>A	c.(4273-4275)GCC>GCA	p.A1425A		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1425	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGTGGAAATGGCATCTCCAA	0.527													4	24	---	---	---	---	PASS
TLN1	7094	broad.mit.edu	37	9	35720146	35720146	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:35720146T>C	uc003zxt.2	-	13	1708	c.1354A>G	c.(1354-1356)ATC>GTC	p.I452V		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	452					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GAGCGCATGATGGCAGGCAGG	0.592													8	25	---	---	---	---	PASS
C9orf85	138241	broad.mit.edu	37	9	74526735	74526735	+	Nonsense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:74526735A>T	uc004ain.2	+	1	313	c.85A>T	c.(85-87)AAA>TAA	p.K29*	C9orf85_uc004aio.2_RNA|C9orf85_uc010mou.2_RNA|C9orf85_uc010mov.2_RNA|FAM108B1_uc004ail.2_5'Flank|FAM108B1_uc004aim.1_5'Flank	NM_182505	NP_872311	Q96MD7	CI085_HUMAN	hypothetical protein LOC138241	29	Lys-rich.										0						CAAGTTCGATAAAAGTGTGCA	0.507													25	58	---	---	---	---	PASS
PRUNE2	158471	broad.mit.edu	37	9	79325136	79325136	+	Nonsense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:79325136G>C	uc010mpk.2	-	8	2178	c.2054C>G	c.(2053-2055)TCA>TGA	p.S685*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	685					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CTCTTTCCATGATTCAGGGCT	0.473													7	29	---	---	---	---	PASS
AGTPBP1	23287	broad.mit.edu	37	9	88200380	88200380	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:88200380T>A	uc011ltd.1	-	22	3196	c.3163A>T	c.(3163-3165)AGG>TGG	p.R1055W	AGTPBP1_uc004aod.3_Missense_Mutation_p.R681W|AGTPBP1_uc011ltc.1_Intron|AGTPBP1_uc010mqc.2_Missense_Mutation_p.R1015W|AGTPBP1_uc011lte.1_Missense_Mutation_p.R1067W	NM_015239	NP_056054	Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	1055					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(4)|large_intestine(2)|skin(1)	7						ATAATTACCCTGTATCCCGTA	0.313													9	52	---	---	---	---	PASS
PHF2	5253	broad.mit.edu	37	9	96416756	96416756	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:96416756G>T	uc004aub.2	+	7	998	c.851G>T	c.(850-852)TGG>TTG	p.W284L	PHF2_uc011lug.1_Missense_Mutation_p.W167L	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	284	JmjC.				liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		TATGAGCGCTGGCGGTCTGCC	0.582													5	51	---	---	---	---	PASS
PHF2	5253	broad.mit.edu	37	9	96437969	96437969	+	Silent	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:96437969C>T	uc004aub.2	+	20	2877	c.2730C>T	c.(2728-2730)GTC>GTT	p.V910V	PHF2_uc011lug.1_Silent_p.V793V|PHF2_uc004auc.2_Silent_p.V330V	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	910					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		CAGCAAGGGTCGGCCCATCGG	0.657													11	28	---	---	---	---	PASS
COL15A1	1306	broad.mit.edu	37	9	101747997	101747997	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:101747997C>T	uc004azb.1	+	3	457	c.251C>T	c.(250-252)CCA>CTA	p.P84L	COL15A1_uc004aza.2_Missense_Mutation_p.P84L	NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	84	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				ACTCTCATCCCATCCACCTTC	0.617													5	37	---	---	---	---	PASS
HSPA5	3309	broad.mit.edu	37	9	128001220	128001220	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:128001220C>A	uc004bpn.2	-	5	1252	c.996G>T	c.(994-996)ATG>ATT	p.M332I		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	332					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	AGGAACATACCATGTTGAGCT	0.398										Prostate(1;0.17)			5	48	---	---	---	---	PASS
ANKRD30A	91074	broad.mit.edu	37	10	37508523	37508523	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:37508523A>G	uc001iza.1	+	34	3814	c.3715A>G	c.(3715-3717)ATG>GTG	p.M1239V		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1295	Potential.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ACAGTGTCAAATGAAGGAAGC	0.358													7	17	---	---	---	---	PASS
PGBD3	267004	broad.mit.edu	37	10	50723876	50723876	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:50723876G>T	uc001jht.2	-	2	1540	c.1285C>A	c.(1285-1287)CAT>AAT	p.H429N	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Missense_Mutation_p.H897N|PGBD3_uc001jhu.2_Missense_Mutation_p.H897N	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	429										pancreas(1)|breast(1)|skin(1)	3						CACAGGGGATGGATACCAGCA	0.428													5	73	---	---	---	---	PASS
PRKG1	5592	broad.mit.edu	37	10	54048748	54048748	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:54048748G>A	uc001jjm.2	+	16	2039	c.1845G>A	c.(1843-1845)AAG>AAA	p.K615K	PRKG1_uc001jjo.2_Silent_p.K630K|PRKG1_uc009xow.1_Silent_p.K333K|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	615	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		ACATTCAAAAGCACAAGTAAG	0.313													19	51	---	---	---	---	PASS
BICC1	80114	broad.mit.edu	37	10	60546717	60546717	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:60546717A>T	uc001jki.1	+	5	422	c.422A>T	c.(421-423)CAT>CTT	p.H141L		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	141	KH 1.				multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						GATGTTTCACATACAGAACAT	0.363													5	16	---	---	---	---	PASS
ANK3	288	broad.mit.edu	37	10	61835211	61835211	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:61835211C>A	uc001jky.2	-	37	5620	c.5428G>T	c.(5428-5430)GCA>TCA	p.A1810S	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1810	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GAGGTAGTTGCAGATATTGAC	0.423													21	91	---	---	---	---	PASS
LRIT2	340745	broad.mit.edu	37	10	85982088	85982088	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:85982088C>A	uc001kcy.2	-	3	1249	c.1241G>T	c.(1240-1242)GGA>GTA	p.G414V	LRIT2_uc010qmc.1_Missense_Mutation_p.G424V	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	414	Fibronectin type-III.					integral to membrane				ovary(2)	2						AGTATTGATTCCGGGGCCAAT	0.552													29	29	---	---	---	---	PASS
SLK	9748	broad.mit.edu	37	10	105779491	105779491	+	Splice_Site	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:105779491G>T	uc001kxo.1	+	16	3167	c.3133_splice	c.e16-1	p.E1045_splice	SLK_uc001kxp.1_Splice_Site_p.E1014_splice	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2						apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AACTTTCATAGGAAACAGAGC	0.358													5	74	---	---	---	---	PASS
AFAP1L2	84632	broad.mit.edu	37	10	116060044	116060044	+	Missense_Mutation	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:116060044G>C	uc001lbn.2	-	15	2167	c.1866C>G	c.(1864-1866)ATC>ATG	p.I622M	AFAP1L2_uc001lbo.2_Missense_Mutation_p.I622M|AFAP1L2_uc010qse.1_Missense_Mutation_p.I675M|AFAP1L2_uc001lbp.2_Missense_Mutation_p.I650M|AFAP1L2_uc001lbr.1_Missense_Mutation_p.I621M|AFAP1L2_uc001lbm.2_Missense_Mutation_p.I61M|AFAP1L2_uc010qsd.1_Missense_Mutation_p.I188M|AFAP1L2_uc001lbq.1_Missense_Mutation_p.I144M	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	622					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GTGGGAAGGAGATTCTCTGCT	0.597													25	39	---	---	---	---	PASS
DOCK1	1793	broad.mit.edu	37	10	129237453	129237453	+	Silent	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:129237453C>T	uc001ljt.2	+	49	5224	c.5160C>T	c.(5158-5160)TCC>TCT	p.S1720S	DOCK1_uc010qun.1_Silent_p.S1741S|DOCK1_uc009yaq.2_Silent_p.S715S	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	1720					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CCGACATTTCCCTGCAGCAGT	0.403													8	12	---	---	---	---	PASS
KNDC1	85442	broad.mit.edu	37	10	135027589	135027589	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr10:135027589G>T	uc001llz.1	+	26	4641	c.4640G>T	c.(4639-4641)TGG>TTG	p.W1547L		NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	1547	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GTCAGCACCTGGGTGGCTGCA	0.572													14	11	---	---	---	---	PASS
MUC6	4588	broad.mit.edu	37	11	1031985	1031985	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:1031985C>G	uc001lsw.2	-	3	235	c.184G>C	c.(184-186)GAC>CAC	p.D62H		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	62	VWFD 1.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCGAGAAGTCGTACACGTGG	0.632													19	33	---	---	---	---	PASS
OR52K2	119774	broad.mit.edu	37	11	4471455	4471455	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:4471455G>A	uc001lyz.1	+	1	886	c.886G>A	c.(886-888)GTC>ATC	p.V296I		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	296	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		AATCTATGGTGTCAAGACCAA	0.507													12	45	---	---	---	---	PASS
OR52J3	119679	broad.mit.edu	37	11	5068652	5068652	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:5068652G>T	uc010qyv.1	+	1	897	c.897G>T	c.(895-897)CAG>CAT	p.Q299H		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	299	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGACCAAACAGATTCGAGAAC	0.378													20	38	---	---	---	---	PASS
WT1	7490	broad.mit.edu	37	11	32439126	32439126	+	Missense_Mutation	SNP	T	G	G	rs67297380		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:32439126T>G	uc001mtn.1	-	4	1143	c.947A>C	c.(946-948)AAG>ACG	p.K316T	WT1_uc001mtl.1_Missense_Mutation_p.K104T|WT1_uc001mtm.1_Missense_Mutation_p.K104T|WT1_uc001mto.1_Missense_Mutation_p.K316T|WT1_uc001mtp.1_Missense_Mutation_p.K316T|WT1_uc001mtq.1_Missense_Mutation_p.K316T|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	248					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.E316fs*4(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			ACCTTACCCCTTTAAGGTGGC	0.368			D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				5	37	---	---	---	---	PASS
FOLH1	2346	broad.mit.edu	37	11	49175867	49175867	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:49175867C>T	uc001ngy.2	-	16	2062	c.1801G>A	c.(1801-1803)GCT>ACT	p.A601T	FOLH1_uc001ngx.2_Missense_Mutation_p.A33T|FOLH1_uc001ngz.2_Missense_Mutation_p.A601T|FOLH1_uc009yly.2_Missense_Mutation_p.A586T|FOLH1_uc009ylz.2_Missense_Mutation_p.A586T|FOLH1_uc009yma.2_Missense_Mutation_p.A293T	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	601	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AAAACTACAGCATAATCTCGA	0.393													11	26	---	---	---	---	PASS
OR5M3	219482	broad.mit.edu	37	11	56237681	56237681	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:56237681T>C	uc010rjk.1	-	1	293	c.293A>G	c.(292-294)CAG>CGG	p.Q98R		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	98	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GAAGAAACACTGTACTAAACA	0.368													23	53	---	---	---	---	PASS
AHNAK	79026	broad.mit.edu	37	11	62288412	62288412	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:62288412C>T	uc001ntl.2	-	5	13777	c.13477G>A	c.(13477-13479)GTA>ATA	p.V4493I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4493					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAATGTCTACCTCTGGCCCT	0.448													25	64	---	---	---	---	PASS
CDK2AP2	10263	broad.mit.edu	37	11	67275064	67275064	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:67275064T>A	uc001oma.2	-	2	728	c.179A>T	c.(178-180)CAG>CTG	p.Q60L	PITPNM1_uc001oly.2_5'Flank|PITPNM1_uc001olz.2_5'Flank|CDK2AP2_uc009yry.2_RNA|CDK2AP2_uc001omb.2_Missense_Mutation_p.Q69L	NM_005851	NP_005842	O75956	CDKA2_HUMAN	cyclin-dependent kinase 2 associated protein 2	60											0						CCCACTCACCTGCACGTAGCC	0.622													12	26	---	---	---	---	PASS
TYR	7299	broad.mit.edu	37	11	89017960	89017960	+	Nonsense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:89017960C>T	uc001pcs.2	+	4	1286	c.1204C>T	c.(1204-1206)CGA>TGA	p.R402*		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	402	Lumenal, melanosome (Potential).		R -> L (in OCA1A).|R -> G (in OCA1B).		eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GCAGTGGCTCCGAAGGCACCG	0.373									Oculocutaneous_Albinism				6	11	---	---	---	---	PASS
ACAT1	38	broad.mit.edu	37	11	108004595	108004595	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:108004595G>T	uc001pjy.2	+	3	245	c.169G>T	c.(169-171)GGC>TGC	p.G57C	ACAT1_uc001pjw.1_Missense_Mutation_p.G57C|ACAT1_uc001pjx.2_Translation_Start_Site	NM_000019	NP_000010	P24752	THIL_HUMAN	acetyl-Coenzyme A acetyltransferase 1 precursor	57					acetoacetic acid biosynthetic process|branched chain family amino acid catabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	acetyl-CoA C-acetyltransferase activity|metal ion binding			ovary(3)	3		all_cancers(61;6.41e-10)|all_epithelial(67;2.83e-06)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;2.96e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.00108)|OV - Ovarian serous cystadenocarcinoma(223;0.192)	Sulfasalazine(DB00795)	ATCTTTTTTAGGCAGCCTTTC	0.418													4	29	---	---	---	---	PASS
ALG9	79796	broad.mit.edu	37	11	111706942	111706942	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:111706942G>T	uc001pmb.2	-	14	1626	c.1527C>A	c.(1525-1527)ACC>ACA	p.T509T	ALG9_uc001ply.2_Silent_p.T338T|ALG9_uc001plz.2_Silent_p.T345T|ALG9_uc010rwm.1_Silent_p.T516T|ALG9_uc010rwn.1_Silent_p.T463T|ALG9_uc010rwo.1_Silent_p.T337T	NM_001077690	NP_001071158	Q9H6U8	ALG9_HUMAN	asparagine-linked glycosylation 9 protein	509	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			large_intestine(1)|ovary(1)	2		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		GAACAATCCGGGTGGCCAGAG	0.438													5	46	---	---	---	---	PASS
OR4D5	219875	broad.mit.edu	37	11	123811094	123811094	+	Silent	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:123811094C>A	uc001pzk.1	+	1	771	c.771C>A	c.(769-771)GTC>GTA	p.V257V		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GCATCTACGTCTATACAAGGC	0.532													25	36	---	---	---	---	PASS
TMEM45B	120224	broad.mit.edu	37	11	129722407	129722407	+	Silent	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:129722407A>G	uc001qfe.1	+	2	91	c.30A>G	c.(28-30)CCA>CCG	p.P10P	TMEM45B_uc001qff.1_Silent_p.P10P	NM_138788	NP_620143	Q96B21	TM45B_HUMAN	transmembrane protein 45B	10	Helical; (Potential).					integral to membrane					0	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		ACGCGCTTCCAGGGAGTTTCT	0.468													10	26	---	---	---	---	PASS
ADAMTS15	170689	broad.mit.edu	37	11	130343024	130343024	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:130343024G>T	uc010scd.1	+	8	2161	c.2161G>T	c.(2161-2163)GGG>TGG	p.G721W		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	721	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		AGGGCTGATCGGGGATGACAA	0.622													20	16	---	---	---	---	PASS
GLB1L2	89944	broad.mit.edu	37	11	134239766	134239766	+	Missense_Mutation	SNP	C	A	A	rs149460505		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr11:134239766C>A	uc001qhp.2	+	11	1283	c.1095C>A	c.(1093-1095)TTC>TTA	p.F365L	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	365					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		GAGACTTCTTCGGCTCCATCT	0.537													4	53	---	---	---	---	PASS
MFAP5	8076	broad.mit.edu	37	12	8813482	8813482	+	Missense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:8813482A>T	uc001qut.1	-	3	284	c.71T>A	c.(70-72)CTG>CAG	p.L24Q	MFAP5_uc001qus.2_Missense_Mutation_p.L24Q|MFAP5_uc009zge.1_Missense_Mutation_p.L24Q	NM_003480	NP_003471	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5 precursor	24						microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)					ATTGACCCCCAGGGGTATCCA	0.428													10	61	---	---	---	---	PASS
PZP	5858	broad.mit.edu	37	12	9305507	9305507	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:9305507G>T	uc001qvl.2	-	31	4063	c.4034C>A	c.(4033-4035)TCC>TAC	p.S1345Y	PZP_uc009zgl.2_Missense_Mutation_p.S1131Y	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						AGCAAATGGGGAGTCCTCTTT	0.443													30	43	---	---	---	---	PASS
PRB1	5542	broad.mit.edu	37	12	11506883	11506883	+	Missense_Mutation	SNP	G	T	T	rs141106766		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:11506883G>T	uc001qzw.1	-	3	191	c.154C>A	c.(154-156)CCT>ACT	p.P52T	PRB1_uc001qzu.1_Missense_Mutation_p.P52T|PRB1_uc001qzv.1_Missense_Mutation_p.P52T	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	52						extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			CCTGGAGGAGGTGGGGGGCCC	0.577													41	130	---	---	---	---	PASS
PTPRO	5800	broad.mit.edu	37	12	15654661	15654661	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:15654661G>A	uc001rcv.1	+	5	943	c.769G>A	c.(769-771)GAT>AAT	p.D257N	PTPRO_uc001rcw.1_Missense_Mutation_p.D257N|PTPRO_uc001rcu.1_Missense_Mutation_p.D257N	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	257	Fibronectin type-III 3.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				GAGATCACAAGATACAATAGG	0.393													11	33	---	---	---	---	PASS
RPS26	6231	broad.mit.edu	37	12	56436328	56436328	+	Missense_Mutation	SNP	T	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:56436328T>G	uc001sjf.2	+	2	388	c.123T>G	c.(121-123)ATT>ATG	p.I41M		NM_001029	NP_001020	P62854	RS26_HUMAN	ribosomal protein S26	41					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	mRNA binding|protein binding|structural constituent of ribosome			breast(1)	1			OV - Ovarian serous cystadenocarcinoma(18;0.123)			AATTCGTCATTCGAAACATAG	0.557													5	33	---	---	---	---	PASS
ATP5B	506	broad.mit.edu	37	12	57033843	57033843	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:57033843G>T	uc001slr.2	-	8	1313	c.1208C>A	c.(1207-1209)TCC>TAC	p.S403Y		NM_001686	NP_001677	P06576	ATPB_HUMAN	mitochondrial ATP synthase beta subunit	403					angiogenesis|ATP hydrolysis coupled proton transport|regulation of intracellular pH|respiratory electron transport chain	cell surface|mitochondrial nucleoid|mitochondrial proton-transporting ATP synthase, catalytic core|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|hydrogen-exporting ATPase activity, phosphorylative mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			ovary(1)	1						ACGAGAGGTGGAGTCTAGAGG	0.522													5	62	---	---	---	---	PASS
SLC16A7	9194	broad.mit.edu	37	12	60169075	60169075	+	Silent	SNP	G	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:60169075G>C	uc001sqs.2	+	5	1298	c.999G>C	c.(997-999)CTG>CTC	p.L333L	SLC16A7_uc001sqt.2_Silent_p.L333L|SLC16A7_uc001squ.2_Silent_p.L333L|SLC16A7_uc009zqi.2_Silent_p.L234L|SLC16A7_uc010ssi.1_Silent_p.L234L	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	333	Helical; (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TGTGCCCACTGGCACAGGACT	0.423													14	81	---	---	---	---	PASS
ACSS3	79611	broad.mit.edu	37	12	81624881	81624881	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:81624881G>T	uc001szl.1	+	12	1651	c.1560G>T	c.(1558-1560)CAG>CAT	p.Q520H	ACSS3_uc001szm.1_Missense_Mutation_p.Q519H|ACSS3_uc001szn.1_Missense_Mutation_p.Q202H	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	520						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GGAAGAATCAGGAAGCATTCA	0.303													5	18	---	---	---	---	PASS
PPFIA2	8499	broad.mit.edu	37	12	81833821	81833821	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:81833821C>A	uc001szo.1	-	7	736	c.575G>T	c.(574-576)AGG>ATG	p.R192M	PPFIA2_uc010sue.1_Missense_Mutation_p.R92M|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_Intron|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	118										ovary(3)|lung(2)|pancreas(1)	6						CAGTCGCTCCCTTACCTAGAA	0.398													16	17	---	---	---	---	PASS
LRRIQ1	84125	broad.mit.edu	37	12	85547831	85547831	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:85547831G>T	uc001tac.2	+	23	4790	c.4679G>T	c.(4678-4680)AGG>ATG	p.R1560M		NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1560										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATGTTGAAGAGGGCACAGAAA	0.294													3	5	---	---	---	---	PASS
RASSF9	9182	broad.mit.edu	37	12	86199109	86199109	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:86199109C>A	uc001taf.1	-	2	1018	c.679G>T	c.(679-681)GGA>TGA	p.G227*		NM_005447	NP_005438	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family	227	Potential.				endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			ovary(1)	1						TAGTTTTCTCCATCATTTTCT	0.398													51	56	---	---	---	---	PASS
C12orf63	374467	broad.mit.edu	37	12	97150340	97150340	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:97150340G>T	uc001tet.1	+	24	3298	c.3220G>T	c.(3220-3222)GGA>TGA	p.G1074*		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	1074										skin(6)|ovary(1)	7						TCAAAACTCAGGGTAAAAAGA	0.388													9	18	---	---	---	---	PASS
POLR3B	55703	broad.mit.edu	37	12	106889912	106889912	+	Silent	SNP	A	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:106889912A>C	uc001tlp.2	+	24	3015	c.2793A>C	c.(2791-2793)CCA>CCC	p.P931P	POLR3B_uc001tlq.2_Silent_p.P873P	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	931					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TCATGAACCCACACGGCTTCC	0.488													16	98	---	---	---	---	PASS
KSR2	283455	broad.mit.edu	37	12	118199246	118199246	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:118199246C>A	uc001two.2	-	4	524	c.469G>T	c.(469-471)GAG>TAG	p.E157*		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	186	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGGTGGGCTCCGGGGGGCAC	0.637													9	47	---	---	---	---	PASS
DNAH10	196385	broad.mit.edu	37	12	124330532	124330532	+	Missense_Mutation	SNP	G	T	T	rs56096831	by1000genomes	TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:124330532G>T	uc001uft.3	+	31	5316	c.5291G>T	c.(5290-5292)CGA>CTA	p.R1764L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1764	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTGGAGGCCCGAGAGTTTGAC	0.557													7	94	---	---	---	---	PASS
RIMBP2	23504	broad.mit.edu	37	12	130897317	130897317	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:130897317C>A	uc001uil.2	-	15	2832	c.2668G>T	c.(2668-2670)GAC>TAC	p.D890Y		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	890	SH3 2.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CCATCAGCGTCTTTATCACCA	0.448													17	29	---	---	---	---	PASS
EP400	57634	broad.mit.edu	37	12	132516566	132516566	+	Silent	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:132516566C>A	uc001ujn.2	+	29	5858	c.5823C>A	c.(5821-5823)ACC>ACA	p.T1941T	EP400_uc001ujl.2_Silent_p.T1940T|EP400_uc001ujm.2_Silent_p.T1860T	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1977	Helicase C-terminal.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ACAGCCGTACCACAGGTATAA	0.463													6	126	---	---	---	---	PASS
KBTBD6	89890	broad.mit.edu	37	13	41706151	41706151	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr13:41706151C>A	uc001uxu.1	-	1	786	c.497G>T	c.(496-498)CGA>CTA	p.R166L	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.R100L|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	166							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		GTCAAGACGTCGGGCTAAGAA	0.582													25	26	---	---	---	---	PASS
KCTD4	386618	broad.mit.edu	37	13	45768460	45768460	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr13:45768460C>G	uc001uzx.3	-	2	647	c.243G>C	c.(241-243)AGG>AGC	p.R81S	GTF2F2_uc001uzv.2_Intron|GTF2F2_uc001uzw.2_Intron	NM_198404	NP_940686	Q8WVF5	KCTD4_HUMAN	potassium channel tetramerisation domain	81	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity				0		Lung NSC(96;6.55e-05)|Breast(139;0.00378)|Prostate(109;0.00438)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000249)|BRCA - Breast invasive adenocarcinoma(63;0.207)		GGAGACCATCCCTGTCTATGA	0.428													20	41	---	---	---	---	PASS
ERCC5	2073	broad.mit.edu	37	13	103515036	103515036	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr13:103515036G>A	uc001vpw.2	+	8	1980	c.1537G>A	c.(1537-1539)GCA>ACA	p.A513T	ERCC5_uc001vpu.1_Missense_Mutation_p.A967T|ERCC5_uc010tjb.1_Missense_Mutation_p.A513T|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.A345T	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	513					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACATAGTGACGCACCTGGGCT	0.488			Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				5	32	---	---	---	---	PASS
OR4L1	122742	broad.mit.edu	37	14	20528227	20528227	+	Silent	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr14:20528227A>G	uc001vwn.1	+	1	24	c.24A>G	c.(22-24)CTA>CTG	p.L8L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		ATGGATCTCTAGTGACCGAGT	0.338													20	26	---	---	---	---	PASS
RALGAPA1	253959	broad.mit.edu	37	14	36159126	36159126	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr14:36159126C>A	uc001wti.2	-	17	2741	c.2350G>T	c.(2350-2352)GGT>TGT	p.G784C	RALGAPA1_uc001wtj.2_Missense_Mutation_p.G784C|RALGAPA1_uc010tpv.1_Missense_Mutation_p.G784C|RALGAPA1_uc010tpw.1_Missense_Mutation_p.G831C|RALGAPA1_uc001wtk.1_Missense_Mutation_p.G682C	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	784					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TTCAAAGCACCAAAAACTTCA	0.408													4	35	---	---	---	---	PASS
C14orf28	122525	broad.mit.edu	37	14	45369749	45369749	+	Silent	SNP	T	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr14:45369749T>G	uc001wvo.2	+	2	377	c.111T>G	c.(109-111)GCT>GCG	p.A37A	C14orf28_uc001wvp.1_Silent_p.A37A	NM_001017923	NP_001017923	Q4W4Y0	CN028_HUMAN	hypothetical protein LOC122525	37										ovary(1)	1						CTATCAAAGCTGGCCGCAAAG	0.363													12	27	---	---	---	---	PASS
AK7	122481	broad.mit.edu	37	14	96864475	96864475	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr14:96864475G>A	uc001yfn.2	+	2	213	c.169G>A	c.(169-171)GAT>AAT	p.D57N	AK7_uc001yfm.1_Missense_Mutation_p.D57N	NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	57	Poly-Glu.|Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		GGAAGAGGAAGATGAAAATAA	0.468													16	77	---	---	---	---	PASS
C15orf2	23742	broad.mit.edu	37	15	24921171	24921171	+	Silent	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr15:24921171C>A	uc001ywo.2	+	1	631	c.157C>A	c.(157-159)CGG>AGG	p.R53R		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	53					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTGTTCCGCCGGAACGCCCG	0.756													8	16	---	---	---	---	PASS
BUB1B	701	broad.mit.edu	37	15	40462841	40462841	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr15:40462841T>C	uc001zkx.3	+	4	555	c.343T>C	c.(343-345)TAT>CAT	p.Y115H		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	115	BUB1 N-terminal.|Nuclear localization signal (Potential).				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		AGAAAAACGATATTATAGTGA	0.363			Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				12	32	---	---	---	---	PASS
UNC13C	440279	broad.mit.edu	37	15	54305912	54305912	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr15:54305912A>G	uc002ack.2	+	1	812	c.812A>G	c.(811-813)AAG>AGG	p.K271R		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	271					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATGCTCTCAAGCACTCCATC	0.453													52	71	---	---	---	---	PASS
SCAPER	49855	broad.mit.edu	37	15	77092589	77092589	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr15:77092589C>A	uc002bby.2	-	6	670	c.611G>T	c.(610-612)GGA>GTA	p.G204V	SCAPER_uc002bbx.2_5'UTR|SCAPER_uc002bbz.1_Missense_Mutation_p.G69V|SCAPER_uc002bca.1_Missense_Mutation_p.G69V|SCAPER_uc002bcb.1_Missense_Mutation_p.G204V|SCAPER_uc002bcc.1_Missense_Mutation_p.G204V	NM_020843	NP_065894	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	203						endoplasmic reticulum|nucleus	zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3						TTCATCTCACCCAAAATTTAA	0.318													11	24	---	---	---	---	PASS
PSTPIP1	9051	broad.mit.edu	37	15	77328172	77328172	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr15:77328172G>A	uc002bcf.2	+	14	1465	c.1015G>A	c.(1015-1017)GAG>AAG	p.E339K	PSTPIP1_uc010bkt.1_RNA|PSTPIP1_uc010bku.1_Missense_Mutation_p.E330K|PSTPIP1_uc002bcg.2_Missense_Mutation_p.E336K|PSTPIP1_uc010bkw.1_Missense_Mutation_p.E320K|PSTPIP1_uc002bch.1_Missense_Mutation_p.E100K|PSTPIP1_uc002bci.1_RNA	NM_003978	NP_003969	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting	339					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			ovary(1)	1						CCCCACCCCCGAGCGGAATGA	0.607													6	16	---	---	---	---	PASS
PCSK6	5046	broad.mit.edu	37	15	101933589	101933589	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr15:101933589C>A	uc002bwy.2	-	9	1351	c.1037G>T	c.(1036-1038)GGG>GTG	p.G346V	PCSK6_uc010bpd.2_Missense_Mutation_p.G216V|PCSK6_uc010bpe.2_Missense_Mutation_p.G346V|PCSK6_uc002bxa.2_Missense_Mutation_p.G346V|PCSK6_uc002bxb.2_Missense_Mutation_p.G346V|PCSK6_uc002bxc.1_Missense_Mutation_p.G346V|PCSK6_uc002bxd.1_Missense_Mutation_p.G346V|PCSK6_uc002bxe.2_Missense_Mutation_p.G346V|PCSK6_uc002bxg.1_Missense_Mutation_p.G346V	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	346	Catalytic.				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCCGCCATTCCCAGATGCCCA	0.622													14	16	---	---	---	---	PASS
PKD1	5310	broad.mit.edu	37	16	2141865	2141865	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:2141865G>A	uc002cos.1	-	41	11663	c.11454C>T	c.(11452-11454)GGC>GGT	p.G3818G	PKD1_uc002cot.1_Silent_p.G3817G|MIR1225_hsa-mir-1225|MI0006311_5'Flank|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3818	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCTGCACGTAGCCCCCGCTGT	0.711													3	3	---	---	---	---	PASS
SRRM2	23524	broad.mit.edu	37	16	2816580	2816580	+	Silent	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:2816580C>T	uc002crk.2	+	11	6600	c.6051C>T	c.(6049-6051)CGC>CGT	p.R2017R	SRRM2_uc002crj.1_Silent_p.R1921R|SRRM2_uc002crl.1_Silent_p.R2017R|SRRM2_uc010bsu.1_Silent_p.R1921R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	2017	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CACGCCGCCGCTCTAGGTCCC	0.582													6	29	---	---	---	---	PASS
ACSM5	54988	broad.mit.edu	37	16	20430682	20430682	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:20430682G>A	uc002dhe.2	+	4	695	c.548G>A	c.(547-549)TGC>TAC	p.C183Y	ACSM5_uc002dhd.1_Missense_Mutation_p.C183Y	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	183					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						AGTGCCGAATGCCCCTCCCTC	0.592													13	23	---	---	---	---	PASS
GTF3C1	2975	broad.mit.edu	37	16	27518417	27518417	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:27518417C>A	uc002dov.1	-	9	1343	c.1303G>T	c.(1303-1305)GAG>TAG	p.E435*	GTF3C1_uc002dou.2_Nonsense_Mutation_p.E435*	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	435						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TCGCTCTCCTCTGCAAACACG	0.557													10	27	---	---	---	---	PASS
ABCC12	94160	broad.mit.edu	37	16	48142361	48142361	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:48142361C>A	uc002efc.1	-	17	2707	c.2361G>T	c.(2359-2361)AAG>AAT	p.K787N	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	787						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CTCCAGAAGCCTTAATGTACG	0.398													4	31	---	---	---	---	PASS
RBL2	5934	broad.mit.edu	37	16	53524121	53524121	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:53524121G>A	uc002ehi.3	+	22	3447	c.3329G>A	c.(3328-3330)AGT>AAT	p.S1110N	RBL2_uc002ehj.2_Missense_Mutation_p.S820N|RBL2_uc010vgw.1_Missense_Mutation_p.S489N	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1110					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GAAGATGGAAGTGAATCACCT	0.403													7	42	---	---	---	---	PASS
DPEP2	64174	broad.mit.edu	37	16	68023977	68023977	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:68023977G>T	uc010cey.2	-	7	1131	c.967C>A	c.(967-969)CCA>ACA	p.P323T	DPEP2_uc002evd.3_Missense_Mutation_p.P323T|DPEP2_uc002eve.2_Missense_Mutation_p.P323T|DPEP2_uc002evf.2_RNA	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	323					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TTGGCTGATGGGTTGCACTGT	0.572													6	85	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7577580	7577580	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:7577580T>C	uc002gim.2	-	7	895	c.701A>G	c.(700-702)TAC>TGC	p.Y234C	TP53_uc002gig.1_Missense_Mutation_p.Y234C|TP53_uc002gih.2_Missense_Mutation_p.Y234C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.Y102C|TP53_uc010cng.1_Missense_Mutation_p.Y102C|TP53_uc002gii.1_Missense_Mutation_p.Y102C|TP53_uc010cnh.1_Missense_Mutation_p.Y234C|TP53_uc010cni.1_Missense_Mutation_p.Y234C|TP53_uc002gij.2_Missense_Mutation_p.Y234C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.Y141C|TP53_uc002gio.2_Missense_Mutation_p.Y102C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	234	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		Y -> F (in a sporadic cancer; somatic mutation).|Y -> K (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|Y -> N (in sporadic cancers; somatic mutation).|Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> Q (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y234C(70)|p.Y234H(13)|p.Y234N(11)|p.0?(7)|p.Y234S(6)|p.Y234*(4)|p.Y234D(3)|p.Y234del(3)|p.Y234fs*2(1)|p.V225fs*23(1)|p.Y234fs*6(1)|p.Y234fs*5(1)|p.Y234fs*4(1)|p.Y234R(1)|p.Y234Y(1)|p.H233_C242del10(1)|p.D228fs*12(1)|p.Y234F(1)|p.I232_Y236delIHYNY(1)|p.Y141S(1)|p.T230_Y234delTTIHY(1)|p.H233fs*6(1)|p.Y234_N235insX(1)|p.I232fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATGTAGTTGTAGTGGATGGT	0.572		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	10	---	---	---	---	PASS
MAP2K3	5606	broad.mit.edu	37	17	21204224	21204224	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:21204224G>A	uc002gys.2	+	5	583	c.318G>A	c.(316-318)CGG>CGA	p.R106R	MAP2K3_uc002gyt.2_Silent_p.R77R|MAP2K3_uc002gyu.2_Silent_p.R77R	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	106	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		AGCAGAAGCGGCTGCTCATGG	0.582													5	32	---	---	---	---	PASS
ACACA	31	broad.mit.edu	37	17	35591902	35591902	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:35591902G>A	uc002hnm.2	-	25	3314	c.3123C>T	c.(3121-3123)GTC>GTT	p.V1041V	ACACA_uc002hnk.2_Silent_p.V963V|ACACA_uc002hnl.2_Silent_p.V983V|ACACA_uc002hnn.2_Silent_p.V1041V|ACACA_uc002hno.2_Silent_p.V1078V|ACACA_uc010cuz.2_Silent_p.V1041V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1041					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TAAGCATTGTGACCAGAAGAT	0.378													10	38	---	---	---	---	PASS
CACNB1	782	broad.mit.edu	37	17	37333659	37333659	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:37333659G>T	uc002hrm.1	-	13	1429	c.1276C>A	c.(1276-1278)CGC>AGC	p.R426S	CACNB1_uc002hrl.1_Missense_Mutation_p.R198S|CACNB1_uc002hrn.2_Missense_Mutation_p.R426S|CACNB1_uc002hro.2_Missense_Mutation_p.R471S	NM_000723	NP_000714	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1	426					axon guidance	voltage-gated calcium channel complex				large_intestine(1)|ovary(1)	2					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	GCCATGGTGCGGTTCAGCAGC	0.637													3	3	---	---	---	---	PASS
ITGB3	3690	broad.mit.edu	37	17	45369758	45369758	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:45369758G>A	uc002ilj.2	+	10	1534	c.1514G>A	c.(1513-1515)CGC>CAC	p.R505H	ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	505	I.|Extracellular (Potential).|Cysteine-rich tandem repeats.				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	GAGGACTATCGCCCTTCCCAG	0.627													20	27	---	---	---	---	PASS
C17orf57	124989	broad.mit.edu	37	17	45447834	45447834	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:45447834A>G	uc002iln.2	+	11	1248	c.837A>G	c.(835-837)ATA>ATG	p.I279M	C17orf57_uc002ilm.2_Missense_Mutation_p.I183M|C17orf57_uc002ill.1_Missense_Mutation_p.I35M|C17orf57_uc010daz.1_Missense_Mutation_p.I231M	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	279							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						GGGATATTATATTTACTTTGA	0.299													13	28	---	---	---	---	PASS
KCNJ16	3773	broad.mit.edu	37	17	68129006	68129006	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:68129006G>T	uc002jin.2	+	5	1264	c.778G>T	c.(778-780)GAG>TAG	p.E260*	KCNJ16_uc002jio.2_Nonsense_Mutation_p.E260*|KCNJ16_uc002jip.2_Nonsense_Mutation_p.E260*|KCNJ16_uc002jiq.2_Nonsense_Mutation_p.E292*	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	260	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					AATTGACCATGAGAGCCCTCT	0.438													6	124	---	---	---	---	PASS
ITGB4	3691	broad.mit.edu	37	17	73736921	73736921	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:73736921G>T	uc002jpg.2	+	22	2785	c.2598G>T	c.(2596-2598)CAG>CAT	p.Q866H	ITGB4_uc002jph.2_Missense_Mutation_p.Q866H|ITGB4_uc010dgo.2_Missense_Mutation_p.Q866H|ITGB4_uc002jpi.3_Missense_Mutation_p.Q866H|ITGB4_uc010dgp.1_Missense_Mutation_p.D879Y|ITGB4_uc002jpj.2_Missense_Mutation_p.Q866H	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	866	Cytoplasmic (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			AGCTCCAGCAGACCAAGTTCC	0.682													12	45	---	---	---	---	PASS
QRICH2	84074	broad.mit.edu	37	17	74287768	74287768	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:74287768G>T	uc002jrd.1	-	4	2722	c.2542C>A	c.(2542-2544)CCT>ACT	p.P848T	QRICH2_uc010wsz.1_Missense_Mutation_p.P774T|QRICH2_uc010dgw.1_Intron	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	848							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TCTCTGCCAGGAGGTACCATA	0.473													5	64	---	---	---	---	PASS
SLC25A10	1468	broad.mit.edu	37	17	79671373	79671373	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr17:79671373G>T	uc010wut.1	+	2	299	c.174G>T	c.(172-174)AAG>AAT	p.K58N	MRPL12_uc002kbh.1_Missense_Mutation_p.K58N	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	Error:Variant_position_missing_in_Q9UBX3_after_alignment					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	ACGCCCCCAAGGAGTACCCCC	0.602													7	17	---	---	---	---	PASS
NDC80	10403	broad.mit.edu	37	18	2577814	2577814	+	Silent	SNP	G	T	T	rs148077669		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr18:2577814G>T	uc002kli.2	+	4	431	c.249G>T	c.(247-249)CCG>CCT	p.P83P		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	83	Interaction with the N-terminus of CDCA1.|Nuclear localization.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						TCAAGGACCCGAGACCACTTA	0.363													5	76	---	---	---	---	PASS
LAMA3	3909	broad.mit.edu	37	18	21422480	21422480	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr18:21422480G>T	uc002kuq.2	+	28	3544	c.3458G>T	c.(3457-3459)CGG>CTG	p.R1153L	LAMA3_uc002kur.2_Missense_Mutation_p.R1153L	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1153	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGGTGGCCACGGGCAGGTGAG	0.607													16	34	---	---	---	---	PASS
ZCCHC2	54877	broad.mit.edu	37	18	60223502	60223502	+	Silent	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr18:60223502C>T	uc002lip.3	+	6	1380	c.1380C>T	c.(1378-1380)TCC>TCT	p.S460S	ZCCHC2_uc002lio.2_RNA	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	460					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						TCTTTCAGTCCATATCATCAG	0.358													9	23	---	---	---	---	PASS
LRG1	116844	broad.mit.edu	37	19	4538521	4538521	+	Missense_Mutation	SNP	A	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:4538521A>C	uc002mau.2	-	2	486	c.475T>G	c.(475-477)TGG>GGG	p.W159G	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	159	LRR 3.					extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGTGTAGCCACGAGACCTCC	0.652													29	41	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9025609	9025609	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:9025609C>A	uc002mkp.2	-	15	37049	c.36845G>T	c.(36844-36846)TGC>TTC	p.C12282F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12284	SEA 2.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTCAATCTGCAGCCAGAGTA	0.512													24	63	---	---	---	---	PASS
CALR	811	broad.mit.edu	37	19	13051633	13051633	+	Nonsense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:13051633G>T	uc002mvu.2	+	7	972	c.892G>T	c.(892-894)GAG>TAG	p.E298*	CALR_uc002mvv.2_5'Flank	NM_004343	NP_004334	P27797	CALR_HUMAN	calreticulin precursor	298	P-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGACAACCCCGAGTATTCTCC	0.542													4	56	---	---	---	---	PASS
INSL3	3640	broad.mit.edu	37	19	17927797	17927797	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:17927797C>A	uc002nhm.1	-	2	267	c.262G>T	c.(262-264)GGA>TGA	p.G88*	INSL3_uc010ebf.1_Missense_Mutation_p.W119C|INSL3_uc010ebg.1_RNA	NM_005543	NP_005534	P51460	INSL3_HUMAN	insulin-like 3 precursor	88					cell-cell signaling|spermatogenesis	soluble fraction	hormone activity|insulin receptor binding|signal transducer activity				0						AGGCCAGGTCCCAGCGTGAGA	0.622													8	18	---	---	---	---	PASS
SLC5A5	6528	broad.mit.edu	37	19	17983413	17983413	+	Silent	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:17983413T>A	uc002nhr.3	+	1	632	c.285T>A	c.(283-285)CTT>CTA	p.L95L		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	95	Helical; (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TGGGCCAGCTTCTGAACTCGG	0.652													10	4	---	---	---	---	PASS
NCAN	1463	broad.mit.edu	37	19	19337671	19337671	+	Silent	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:19337671C>T	uc002nlz.2	+	7	1548	c.1449C>T	c.(1447-1449)TTC>TTT	p.F483F	NCAN_uc010ecc.1_Silent_p.F47F	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	483					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGGGGCGCTTCAAAGGGTTGA	0.672													17	20	---	---	---	---	PASS
ZNF14	7561	broad.mit.edu	37	19	19823162	19823162	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:19823162T>C	uc002nnk.1	-	4	1082	c.928A>G	c.(928-930)AAA>GAA	p.K310E		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	310	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				CCACATTCTTTACATTCATAG	0.378													10	30	---	---	---	---	PASS
ZNF431	170959	broad.mit.edu	37	19	21366712	21366712	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:21366712A>G	uc002npp.2	+	5	1753	c.1606A>G	c.(1606-1608)AGA>GGA	p.R536G	ZNF431_uc010ecq.2_Missense_Mutation_p.R445G|ZNF431_uc010ecr.2_Missense_Mutation_p.R537G	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	536					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						AATTCATACTAGACAGAAACC	0.318													7	59	---	---	---	---	PASS
ZNF208	7757	broad.mit.edu	37	19	22154642	22154642	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:22154642G>T	uc002nqp.2	-	6	2959	c.2810C>A	c.(2809-2811)GCC>GAC	p.A937D	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCAGCTGAAGGCTTTGCCACA	0.463													15	61	---	---	---	---	PASS
ZNF461	92283	broad.mit.edu	37	19	37149214	37149214	+	Silent	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:37149214G>A	uc002oem.2	-	3	351	c.123C>T	c.(121-123)AAC>AAT	p.N41N	ZNF461_uc002oen.2_Intron|ZNF461_uc010xtj.1_Silent_p.N41N	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GTGACACCAAGTTGCTATAAT	0.413													5	15	---	---	---	---	PASS
TTC9B	148014	broad.mit.edu	37	19	40722081	40722081	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:40722081C>T	uc002onc.2	-	3	727	c.709G>A	c.(709-711)GTA>ATA	p.V237I		NM_152479	NP_689692	Q8N6N2	TTC9B_HUMAN	tetratricopeptide repeat domain 9B	237							binding				0						CAGCCAATTACATCCCGAGTC	0.557													13	47	---	---	---	---	PASS
AKT2	208	broad.mit.edu	37	19	40747908	40747908	+	Silent	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:40747908C>A	uc002onf.2	-	6	772	c.510G>T	c.(508-510)CGG>CGT	p.R170R	AKT2_uc010egs.2_Silent_p.R170R|AKT2_uc010egt.2_Silent_p.R108R|AKT2_uc010xvj.1_Silent_p.R108R|AKT2_uc010egu.1_Silent_p.R108R|AKT2_uc010xvk.1_Silent_p.R170R|AKT2_uc002one.2_Silent_p.R66R	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	170	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			TGGCCTTCTCCCGCACCAGGA	0.582			A		ovarian|pancreatic 								15	25	---	---	---	---	PASS
CEACAM16	388551	broad.mit.edu	37	19	45207358	45207358	+	Silent	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:45207358T>A	uc010xxd.1	+	4	659	c.453T>A	c.(451-453)CTT>CTA	p.L151L	CEACAM16_uc002ozq.2_Silent_p.L210L	NM_001039213	NP_001034302	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion	151										ovary(1)	1	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				CCCTGCGCCTTATGTGCAGCA	0.697													5	6	---	---	---	---	PASS
TOMM40	10452	broad.mit.edu	37	19	45396132	45396132	+	Silent	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:45396132C>A	uc002ozx.3	+	4	482	c.381C>A	c.(379-381)TCC>TCA	p.S127S	TOMM40_uc002ozy.3_Silent_p.S127S|TOMM40_uc002paa.3_Silent_p.S127S|TOMM40_uc002ozz.2_Silent_p.S127S	NM_006114	NP_006105	O96008	TOM40_HUMAN	translocase of outer mitochondrial membrane 40	127					protein targeting to mitochondrion	integral to membrane of membrane fraction|integral to mitochondrial outer membrane|mitochondrial outer membrane translocase complex|pore complex	porin activity|protein transmembrane transporter activity|voltage-gated anion channel activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)			OV - Ovarian serous cystadenocarcinoma(262;0.0033)|Epithelial(262;0.176)		TCGGGGAGTCCAACTACCACT	0.502													4	37	---	---	---	---	PASS
ZNF611	81856	broad.mit.edu	37	19	53209454	53209454	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:53209454T>C	uc002pzz.2	-	7	1171	c.854A>G	c.(853-855)AAA>AGA	p.K285R	ZNF611_uc010eqc.2_Missense_Mutation_p.K215R|ZNF611_uc010ydo.1_Missense_Mutation_p.K215R|ZNF611_uc010ydr.1_Missense_Mutation_p.K216R|ZNF611_uc010ydp.1_Missense_Mutation_p.K285R|ZNF611_uc010ydq.1_Missense_Mutation_p.K285R|ZNF611_uc002qaa.3_Missense_Mutation_p.K215R	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		CTTGTAAGGTTTCTCAACAGT	0.408													44	72	---	---	---	---	PASS
MIR518D	574489	broad.mit.edu	37	19	54238188	54238188	+	RNA	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:54238188C>T	hsa-mir-518d|MI0003171	+			c.58C>T			MIR516B1_hsa-mir-516b-1|MI0003172_5'Flank																	0						GAAACCAAAGCGCTTCCCTTT	0.438													16	80	---	---	---	---	PASS
CACNG8	59283	broad.mit.edu	37	19	54466592	54466592	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:54466592C>A	uc002qcs.1	+	1	299	c.193C>A	c.(193-195)CCC>ACC	p.P65T		NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	66					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		CGACGGGACCCCCCACCGCGG	0.706													5	4	---	---	---	---	PASS
LILRB5	10990	broad.mit.edu	37	19	54760477	54760477	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr19:54760477G>T	uc002qex.2	-	3	341	c.230C>A	c.(229-231)CCT>CAT	p.P77H	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Missense_Mutation_p.P77H|LILRB5_uc002qey.2_Missense_Mutation_p.P77H|LILRB5_uc002qez.2_Missense_Mutation_p.P77H|LILRB5_uc002qfa.1_Missense_Mutation_p.P67H|LILRB5_uc010yes.1_RNA	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	77	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTTGGCTCCAGGCTCCAGTGG	0.612													38	115	---	---	---	---	PASS
ATRN	8455	broad.mit.edu	37	20	3578558	3578558	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr20:3578558C>G	uc002wim.2	+	22	3565	c.3475C>G	c.(3475-3477)CTT>GTT	p.L1159V	ATRN_uc002wil.2_Missense_Mutation_p.L1159V	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1159	Extracellular (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						CATAGATACTCTTCTTATTGA	0.328													23	57	---	---	---	---	PASS
C20orf30	29058	broad.mit.edu	37	20	5086887	5086887	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr20:5086887C>A	uc002wll.2	-	4	635	c.169G>T	c.(169-171)GCC>TCC	p.A57S	C20orf30_uc010gbi.2_Missense_Mutation_p.A57S|C20orf30_uc002wlk.2_Missense_Mutation_p.A120S|C20orf30_uc002wlm.2_Missense_Mutation_p.A57S|C20orf30_uc002wln.2_Missense_Mutation_p.A57S|C20orf30_uc002wlo.2_Intron	NM_001009924	NP_001009924	Q96A57	CT030_HUMAN	hypothetical protein LOC29058 isoform 2	57	Helical; (Potential).					integral to membrane					0						ATGAGAAAGGCGCCAATCAAA	0.433													21	41	---	---	---	---	PASS
ESF1	51575	broad.mit.edu	37	20	13763342	13763342	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr20:13763342C>T	uc002woj.2	-	2	553	c.445G>A	c.(445-447)GAT>AAT	p.D149N	ESF1_uc002wok.1_Missense_Mutation_p.D149N|C20orf7_uc002wol.1_5'Flank|C20orf7_uc002wom.2_5'Flank|C20orf7_uc002won.2_5'Flank|C20orf7_uc002woo.2_5'Flank	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	149	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						ATGTTTGAATCTATCTTAAAT	0.284													6	21	---	---	---	---	PASS
BFSP1	631	broad.mit.edu	37	20	17492636	17492636	+	Silent	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr20:17492636C>A	uc002wpo.2	-	4	651	c.612G>T	c.(610-612)ACG>ACT	p.T204T	BFSP1_uc002wpp.2_Silent_p.T79T|BFSP1_uc010zrn.1_Silent_p.T65T|BFSP1_uc010zro.1_Silent_p.T65T	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	204	Rod.|Coil 2.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						TCATCCCACTCGTCACAATGG	0.527													11	33	---	---	---	---	PASS
PLCG1	5335	broad.mit.edu	37	20	39791871	39791871	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr20:39791871G>A	uc002xjp.1	+	8	866	c.745G>A	c.(745-747)GTG>ATG	p.V249M	PLCG1_uc002xjo.1_Missense_Mutation_p.V249M|PLCG1_uc010zwe.1_5'Flank|PLCG1_uc010ggf.2_5'Flank	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	249					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GCTTTGCCGAGTGTCCCTTCC	0.602													10	28	---	---	---	---	PASS
DIDO1	11083	broad.mit.edu	37	20	61511762	61511762	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr20:61511762T>A	uc002ydr.1	-	16	5810	c.5546A>T	c.(5545-5547)CAT>CTT	p.H1849L	DIDO1_uc002yds.1_Missense_Mutation_p.H1849L	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1849	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTCTCCCCATGGGGATCCTT	0.607													30	33	---	---	---	---	PASS
CLIC6	54102	broad.mit.edu	37	21	36079604	36079604	+	Silent	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr21:36079604A>T	uc010gmt.1	+	3	1455	c.1455A>T	c.(1453-1455)GGA>GGT	p.G485G	CLIC6_uc002yuf.1_Silent_p.G467G	NM_053277	NP_444507	Q96NY7	CLIC6_HUMAN	chloride intracellular channel 6	485						chloride channel complex|cytoplasm|plasma membrane	voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						AGAGTATCGGAAATTGCCCGT	0.443													19	29	---	---	---	---	PASS
PFKL	5211	broad.mit.edu	37	21	45732984	45732984	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr21:45732984G>T	uc002zel.2	+	5	610	c.551G>T	c.(550-552)CGC>CTC	p.R184L	PFKL_uc002zek.2_Missense_Mutation_p.R231L|PFKL_uc011afd.1_Missense_Mutation_p.R231L	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	184					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		GCCCTCCACCGCATCATGGAG	0.667													37	21	---	---	---	---	PASS
KRTAP10-4	386672	broad.mit.edu	37	21	45994758	45994758	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr21:45994758G>T	uc002zfk.1	+	1	1153	c.1123G>T	c.(1123-1125)GTG>TTG	p.V375L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198687	NP_941960	P60372	KR104_HUMAN	keratin associated protein 10-4	375	36 X 5 AA repeats of C-C-X(3).|35.					keratin filament					0						CGCCTGCTGCGTGCCCGTCCC	0.701													22	28	---	---	---	---	PASS
SLC5A1	6523	broad.mit.edu	37	22	32487631	32487631	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr22:32487631G>T	uc003amc.2	+	11	1394	c.1162G>T	c.(1162-1164)GCC>TCC	p.A388S	SLC5A1_uc011alz.1_Missense_Mutation_p.A261S	NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	388	Helical; (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						AGTCATGCTGGCCTCCCTCAT	0.498													25	52	---	---	---	---	PASS
MCHR1	2847	broad.mit.edu	37	22	41077580	41077580	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr22:41077580C>T	uc003ayz.2	+	2	1185	c.917C>T	c.(916-918)TCC>TTC	p.S306F	MCHR1_uc003aza.2_Missense_Mutation_p.S195F|uc003azb.1_RNA	NM_005297	NP_005288	Q99705	MCHR1_HUMAN	G protein-coupled receptor 24	306	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity				0						CGCATGACGTCCTCAGTGGCC	0.602													17	17	---	---	---	---	PASS
WNT7B	7477	broad.mit.edu	37	22	46327059	46327059	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr22:46327059G>T	uc003bgo.2	-	3	863	c.489C>A	c.(487-489)TCC>TCA	p.S163S	WNT7B_uc010haa.2_Silent_p.S167S	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	163					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CGAAGCGCCGGGAGAAGTCGA	0.652													4	29	---	---	---	---	PASS
OFD1	8481	broad.mit.edu	37	X	13774698	13774698	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:13774698T>A	uc004cvp.3	+	13	1582	c.1223T>A	c.(1222-1224)CTT>CAT	p.L408H	OFD1_uc004cvr.3_Translation_Start_Site|OFD1_uc011mil.1_Translation_Start_Site|OFD1_uc004cvq.3_Missense_Mutation_p.L268H|OFD1_uc010nen.2_Missense_Mutation_p.L407H|OFD1_uc004cvs.3_RNA|OFD1_uc004cvu.3_Missense_Mutation_p.L367H|OFD1_uc004cvv.3_Missense_Mutation_p.L367H	NM_003611	NP_003602	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	408	Potential.				cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding				0						GAATTTTAGCTTGAATTAGAG	0.323													19	65	---	---	---	---	PASS
MAP3K15	389840	broad.mit.edu	37	X	19398285	19398285	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:19398285T>C	uc004czk.1	-	20	2604	c.967A>G	c.(967-969)AAG>GAG	p.K323E	MAP3K15_uc004czj.1_Missense_Mutation_p.K283E	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	848	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					AACGGAGGCTTGCTGGTGGCC	0.512													3	5	---	---	---	---	PASS
ZNF645	158506	broad.mit.edu	37	X	22291549	22291549	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:22291549C>A	uc004dai.1	+	1	490	c.441C>A	c.(439-441)AGC>AGA	p.S147R		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	147						intracellular	zinc ion binding			lung(1)|pancreas(1)	2						AAGTTACCAGCGCTTCGCTTG	0.438													12	46	---	---	---	---	PASS
DCAF8L1	139425	broad.mit.edu	37	X	27997798	27997798	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:27997798C>A	uc004dbx.1	-	1	1769	c.1654G>T	c.(1654-1656)GTG>TTG	p.V552L		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	552										ovary(3)|skin(1)	4						AGGTGACGCACGAAGAACCGA	0.478													13	50	---	---	---	---	PASS
CXorf21	80231	broad.mit.edu	37	X	30577646	30577646	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:30577646A>G	uc004dcg.1	-	3	1103	c.827T>C	c.(826-828)TTG>TCG	p.L276S		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	276										ovary(1)	1						CATCAATTGCAATAGGCGGCT	0.388													11	42	---	---	---	---	PASS
RPGR	6103	broad.mit.edu	37	X	38146392	38146392	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:38146392C>G	uc004ded.1	-	15	2028	c.1860G>C	c.(1858-1860)AAG>AAC	p.K620N	RPGR_uc004deb.2_Missense_Mutation_p.K620N|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_Intron	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	620	Glu-rich.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						CTGTTttctcctttcttcctc	0.239													18	54	---	---	---	---	PASS
EFHC2	80258	broad.mit.edu	37	X	44120491	44120491	+	Missense_Mutation	SNP	A	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:44120491A>G	uc004dgb.3	-	5	526	c.436T>C	c.(436-438)TTT>CTT	p.F146L		NM_025184	NP_079460	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	146	DM10 1.						calcium ion binding			breast(3)|ovary(2)|central_nervous_system(1)	6						ACAGTATAAAACTGATCCTCA	0.408													10	60	---	---	---	---	PASS
ZNF630	57232	broad.mit.edu	37	X	47918465	47918465	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:47918465C>T	uc004div.3	-	5	1618	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.E332K	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						TAAGGTTTTTCTCCTGTATGA	0.448													6	30	---	---	---	---	PASS
PAGE1	8712	broad.mit.edu	37	X	49459326	49459326	+	Nonsense_Mutation	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:49459326A>T	uc004dom.2	-	2	181	c.48T>A	c.(46-48)TAT>TAA	p.Y16*		NM_003785	NP_003776	O75459	GAGB1_HUMAN	P antigen family, member 1	16					cellular defense response					skin(1)	1	Ovarian(276;0.236)					AAGATTCTACATAGATCATTG	0.353													7	44	---	---	---	---	PASS
CLCN5	1184	broad.mit.edu	37	X	49840470	49840470	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:49840470G>A	uc004dos.1	+	4	474	c.226G>A	c.(226-228)GAC>AAC	p.D76N	CLCN5_uc004dor.1_Missense_Mutation_p.D146N|CLCN5_uc004doq.1_Missense_Mutation_p.D146N|CLCN5_uc004dot.1_Missense_Mutation_p.D76N	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	76	Helical; (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					TGGTTTGATAGACATCTCTGC	0.433													12	34	---	---	---	---	PASS
AR	367	broad.mit.edu	37	X	66766093	66766093	+	Missense_Mutation	SNP	C	G	G			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:66766093C>G	uc004dwu.1	+	1	2220	c.1105C>G	c.(1105-1107)CTG>GTG	p.L369V	AR_uc011mpd.1_Missense_Mutation_p.L369V|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.L369V	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	367	Modulating.				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	CAACTTTCCACTGGCTCTGGC	0.662									Androgen_Insensitivity_Syndrome				5	11	---	---	---	---	PASS
CYSLTR1	10800	broad.mit.edu	37	X	77528442	77528442	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:77528442C>T	uc004edb.2	-	3	1202	c.802G>A	c.(802-804)GAT>AAT	p.D268N	CYSLTR1_uc010nma.2_Missense_Mutation_p.D268N|CYSLTR1_uc010nmb.2_Missense_Mutation_p.D268N	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	268	Extracellular (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	AGGACAGAATCACAGGGTTTA	0.418													10	47	---	---	---	---	PASS
CYLC1	1538	broad.mit.edu	37	X	83128189	83128189	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:83128189C>A	uc004eei.1	+	4	494	c.473C>A	c.(472-474)GCA>GAA	p.A158E	CYLC1_uc004eeh.1_Missense_Mutation_p.A157E	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	158					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						CAAAATGAGGCAGATAAAACT	0.338													7	11	---	---	---	---	PASS
PABPC5	140886	broad.mit.edu	37	X	90691646	90691646	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:90691646C>T	uc004efg.2	+	2	1510	c.1070C>T	c.(1069-1071)GCA>GTA	p.A357V	PABPC5_uc004eff.1_Missense_Mutation_p.A193V	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	357	RRM 4.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						GCTACCAAAGCAGTGGATGAG	0.527													12	21	---	---	---	---	PASS
BTK	695	broad.mit.edu	37	X	100630231	100630231	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:100630231G>T	uc004ehg.2	-	2	235	c.42C>A	c.(40-42)TCC>TCA	p.S14S	BTK_uc010nnn.2_Silent_p.S14S|BTK_uc010nno.2_Silent_p.S48S|BTK_uc004ehi.2_Silent_p.S14S	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	14	PH.		S -> F (in XLA).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TTTTCTGTTGGGATCGCTTCA	0.458									Agammaglobulinemia_X-linked				12	98	---	---	---	---	PASS
GPRASP1	9737	broad.mit.edu	37	X	101912635	101912635	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:101912635C>A	uc004ejj.3	+	5	4595	c.3794C>A	c.(3793-3795)ACT>AAT	p.T1265N	GPRASP1_uc004eji.3_Missense_Mutation_p.T1265N|GPRASP1_uc010nod.2_Missense_Mutation_p.T1265N	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1265	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						AGACATCTCACTACTACTACT	0.398													8	66	---	---	---	---	PASS
TCEAL3	85012	broad.mit.edu	37	X	102864368	102864368	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:102864368C>A	uc004ekq.2	+	3	638	c.376C>A	c.(376-378)CAG>AAG	p.Q126K	TCEAL3_uc004ekr.2_Missense_Mutation_p.Q126K	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CAAGGACTCTCAGGAGGACTT	0.532													11	82	---	---	---	---	PASS
ESX1	80712	broad.mit.edu	37	X	103495396	103495396	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:103495396G>A	uc004ely.2	-	4	792	c.734C>T	c.(733-735)CCT>CTT	p.P245L		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	245	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.|1.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGGCAGCACAGGTGGTCTAGG	0.368													19	98	---	---	---	---	PASS
TBC1D8B	54885	broad.mit.edu	37	X	106083927	106083927	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:106083927C>A	uc004emo.2	+	10	1697	c.1532C>A	c.(1531-1533)CCT>CAT	p.P511H	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emn.2_Missense_Mutation_p.P511H	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	511	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GCTACTAATCCTGACTATTAT	0.388													12	46	---	---	---	---	PASS
TBC1D8B	54885	broad.mit.edu	37	X	106097494	106097494	+	Missense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:106097494C>A	uc004emo.2	+	14	2485	c.2320C>A	c.(2320-2322)CAG>AAG	p.Q774K	MORC4_uc004emp.3_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	774						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GTATGTGATACAGACCCTAGA	0.343													7	47	---	---	---	---	PASS
SLC6A14	11254	broad.mit.edu	37	X	115577907	115577907	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:115577907G>T	uc004eqi.2	+	7	894	c.790G>T	c.(790-792)GTG>TTG	p.V264L	SLC6A14_uc011mtm.1_RNA	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	264	Helical; Name=5; (Potential).				cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	TTCTTGGTAGGTGGTATATTT	0.323													22	36	---	---	---	---	PASS
ZCCHC12	170261	broad.mit.edu	37	X	117959684	117959684	+	Silent	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:117959684T>A	uc004equ.2	+	4	950	c.477T>A	c.(475-477)GCT>GCA	p.A159A		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						tccagaacgctattcaggcag	0.124													83	116	---	---	---	---	PASS
UPF3B	65109	broad.mit.edu	37	X	118972475	118972475	+	Nonsense_Mutation	SNP	C	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:118972475C>A	uc004erz.1	-	9	939	c.862G>T	c.(862-864)GAA>TAA	p.E288*	UPF3B_uc004esa.1_Nonsense_Mutation_p.E275*	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	288	Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						TCTCCTTTTTCTGGCTTCTTG	0.323													42	90	---	---	---	---	PASS
UPF3B	65109	broad.mit.edu	37	X	118975200	118975200	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:118975200C>T	uc004erz.1	-	7	723	c.646G>A	c.(646-648)GAA>AAA	p.E216K	UPF3B_uc004esa.1_Missense_Mutation_p.E216K	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	216	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						ctcctttcttctctcttttct	0.149													12	98	---	---	---	---	PASS
UPF3B	65109	broad.mit.edu	37	X	118977226	118977226	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:118977226C>T	uc004erz.1	-	5	585	c.508G>A	c.(508-510)GAT>AAT	p.D170N	UPF3B_uc004esa.1_Missense_Mutation_p.D170N	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	170	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						TTCTCATTATCTGTGGCATAA	0.308													6	88	---	---	---	---	PASS
THOC2	57187	broad.mit.edu	37	X	122801009	122801009	+	Missense_Mutation	SNP	C	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:122801009C>T	uc004etu.2	-	11	1170	c.1138G>A	c.(1138-1140)GCC>ACC	p.A380T	THOC2_uc011muh.1_Missense_Mutation_p.A301T|THOC2_uc011mui.1_Missense_Mutation_p.A265T	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	380					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ATAGCAAGGGCTATTAGCTTG	0.383													11	55	---	---	---	---	PASS
CCDC160	347475	broad.mit.edu	37	X	133379769	133379769	+	Silent	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:133379769A>T	uc011mvj.1	+	2	1260	c.939A>T	c.(937-939)TCA>TCT	p.S313S		NM_001101357	NP_001094827	A6NGH7	CC160_HUMAN	coiled-coil domain containing 160	313										skin(1)	1						TGGTAACATCATCAAGTATCC	0.348													4	22	---	---	---	---	PASS
ZNF75D	7626	broad.mit.edu	37	X	134421514	134421514	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:134421514T>A	uc004eyp.2	-	7	3743	c.1088A>T	c.(1087-1089)AAA>ATA	p.K363I	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.K142I|ZNF75D_uc004eyo.2_Missense_Mutation_p.K268I	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	363					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CTTAAAAGGTTTCTCCCCTGT	0.408													9	35	---	---	---	---	PASS
GPR112	139378	broad.mit.edu	37	X	135496475	135496475	+	Missense_Mutation	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:135496475G>T	uc004ezu.1	+	25	9485	c.9194G>T	c.(9193-9195)AGC>ATC	p.S3065I	GPR112_uc010nsb.1_Missense_Mutation_p.S2860I	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	3065	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TCAGAAATAAGCTTTCCAAAT	0.393													16	102	---	---	---	---	PASS
GPR101	83550	broad.mit.edu	37	X	136112439	136112439	+	Silent	SNP	G	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:136112439G>T	uc011mwh.1	-	1	1395	c.1395C>A	c.(1393-1395)ATC>ATA	p.I465I		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	465	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GCATGTCCTGGATTTCCTTCT	0.507													28	38	---	---	---	---	PASS
MCF2	4168	broad.mit.edu	37	X	138708792	138708792	+	Missense_Mutation	SNP	T	C	C			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:138708792T>C	uc004fau.2	-	5	856	c.562A>G	c.(562-564)ACT>GCT	p.T188A	MCF2_uc004fav.2_Missense_Mutation_p.T188A|MCF2_uc011mwl.1_Missense_Mutation_p.T149A|MCF2_uc010nsh.1_Missense_Mutation_p.T188A|MCF2_uc011mwm.1_Missense_Mutation_p.T149A|MCF2_uc011mwn.1_Missense_Mutation_p.T333A|MCF2_uc004faw.2_Missense_Mutation_p.T248A|MCF2_uc011mwo.1_Missense_Mutation_p.T248A	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	188					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TTATTAATAGTTTGCCAGTCA	0.333													13	107	---	---	---	---	PASS
CXorf66	347487	broad.mit.edu	37	X	139038261	139038261	+	Missense_Mutation	SNP	T	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:139038261T>A	uc004fbb.2	-	3	902	c.880A>T	c.(880-882)ACT>TCT	p.T294S		NM_001013403	NP_001013421	Q5JRM2	CX066_HUMAN	hypothetical protein LOC347487 precursor	294	Cytoplasmic (Potential).					integral to membrane					0						AGGTTTTGAGTGTTTTTCTCC	0.388													10	64	---	---	---	---	PASS
MAGEC3	139081	broad.mit.edu	37	X	140969303	140969303	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:140969303G>A	uc011mwp.1	+	4	630	c.630G>A	c.(628-630)ATG>ATA	p.M210I		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	210	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GAGCAGAGATGCAGATGAATG	0.433													21	106	---	---	---	---	PASS
SLITRK4	139065	broad.mit.edu	37	X	142718108	142718108	+	Missense_Mutation	SNP	G	A	A			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:142718108G>A	uc004fbx.2	-	2	1193	c.817C>T	c.(817-819)CGC>TGC	p.R273C	SLITRK4_uc004fby.2_Missense_Mutation_p.R273C	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	273	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGCAGGATGCGCACGTCAAAA	0.448													13	56	---	---	---	---	PASS
F8	2157	broad.mit.edu	37	X	154185349	154185349	+	Silent	SNP	A	T	T			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chrX:154185349A>T	uc004fmt.2	-	11	1806	c.1635T>A	c.(1633-1635)CCT>CCA	p.P545P		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	545	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCAGGCACCGAGGATCTGATT	0.413													8	81	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	3	156800697	156800697	+	RNA	DEL	A	-	-	rs66530816		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr3:156800697delA	uc003fbc.2	-	4		c.775delT								Homo sapiens cDNA, FLJ18260.																		CTCAGGCAGGAAAAAAAAAAG	0.418													3	6	---	---	---	---	
TMEM63B	55362	broad.mit.edu	37	6	44119666	44119666	+	Frame_Shift_Del	DEL	T	-	-			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr6:44119666delT	uc003owr.2	+	19	1821	c.1757delT	c.(1756-1758)CTGfs	p.L586fs	TMEM63B_uc003ows.2_Frame_Shift_Del_p.L489fs|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	586						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			ATGGACCTGCTGCGCATCCCA	0.657											OREG0017465	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	12	---	---	---	---	
Unknown	0	broad.mit.edu	37	9	68410007	68410009	+	RNA	DEL	CCT	-	-	rs111979970		TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:68410007_68410009delCCT	uc004aew.1	+	1		c.10_12delCCT								Homo sapiens cDNA, FLJ98602.																		tctctctctccctctggttctat	0.074													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	9	97317410	97317411	+	RNA	INS	-	T	T	rs145410254	by1000genomes	TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr9:97317410_97317411insT	uc004aus.1	+	1		c.60_61insT			uc004aut.1_5'Flank|uc004auu.2_5'Flank					Homo sapiens cDNA FLJ41071 fis, clone 3NB692003538.																		ttttgttgttgttttttttgtt	0.000													4	2	---	---	---	---	
MLL2	8085	broad.mit.edu	37	12	49427160	49427160	+	Frame_Shift_Del	DEL	A	-	-			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr12:49427160delA	uc001rta.3	-	39	11328	c.11328delT	c.(11326-11328)CTTfs	p.L3776fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3776	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGGGAGGCATAAGGCCCTGGG	0.617			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	2	---	---	---	---	
MSLNL	401827	broad.mit.edu	37	16	825541	825541	+	Frame_Shift_Del	DEL	C	-	-			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:825541delC	uc002cjz.1	-	5	1220	c.1220delG	c.(1219-1221)GGCfs	p.G407fs		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						TCTGGACTCGCCGTGGCAGCC	0.697													10	7	---	---	---	---	
LOC283922	283922	broad.mit.edu	37	16	74366436	74366436	+	Frame_Shift_Del	DEL	G	-	-			TCGA-66-2727-01A-01D-0983-08	TCGA-66-2727-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	c2b2c909-1461-42ce-8fd9-736147dcacd8	d35d0976-dc9b-48c3-bdb0-016480667eb8	g.chr16:74366436delG	uc002fcr.2	-	14	2278	c.932delC	c.(931-933)CCTfs	p.P311fs	LOC283922_uc010vms.1_RNA					Homo sapiens cDNA FLJ39449 fis, clone PROST2008360, highly similar to Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.												0						ggggaggggaggggaggggag	0.498													4	2	---	---	---	---	
