Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PLEKHM2	23207	broad.mit.edu	37	1	16051962	16051962	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:16051962T>C	uc010obo.1	+	8	1090	c.863T>C	c.(862-864)GTG>GCG	p.V288A		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	288	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ACCACCCCCGTGCACACCACC	0.672													2	5					0	0	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21940122	21940122	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:21940122T>A	uc001bex.2	-	9	731	c.473A>T	c.(472-474)AAG>ATG	p.K158M	RAP1GAP_uc001bev.2_Missense_Mutation_p.K158M|RAP1GAP_uc001bew.2_Missense_Mutation_p.K222M|RAP1GAP_uc001bey.2_Missense_Mutation_p.K158M	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	158					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		AGACCTCACCTTTGCCATCTG	0.597													27	102					0	0	0	0
NRD1	4898	broad.mit.edu	37	1	52305985	52305985	+	Silent	SNP	T	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:52305985T>C	uc001ctc.3	-	2	865	c.543A>G	c.(541-543)GAA>GAG	p.E181E	NRD1_uc009vzb.2_5'UTR|NRD1_uc001ctd.3_Silent_p.E181E|NRD1_uc001cte.2_Silent_p.E49E|NRD1_uc001ctf.2_Silent_p.E181E|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Silent_p.E49E|NRD1_uc001ctg.1_5'Flank	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						catcatcatgttcatcatcaa	0.154													6	15					0	0	0	0
BARHL2	343472	broad.mit.edu	37	1	91182551	91182551	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:91182551C>A	uc001dns.2	-	1	244	c.202G>T	c.(202-204)GTC>TTC	p.V68F		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	68						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		TCCATGGTGACTGAGATAGGA	0.542													5	52					0.000602214	0.00133419	1	0
ZNF644	84146	broad.mit.edu	37	1	91404033	91404033	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:91404033G>A	uc001dnw.2	-	3	3020	c.2878C>T	c.(2878-2880)CTT>TTT	p.L960F	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.L960F	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	960					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTCTTCTCAAGAGACAAATCA	0.398													13	47					0	0	0	0
AMY2B	280	broad.mit.edu	37	1	104115830	104115830	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:104115830G>C	uc001duq.2	+	5	1077	c.461G>C	c.(460-462)GGT>GCT	p.G154A	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.G154A|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	154					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TTTAATGATGGTAAATGTAAA	0.408													64	542					0	0	0	0
GJA8	2703	broad.mit.edu	37	1	147381094	147381095	+	Missense_Mutation	DNP	GC	AA	AA			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:147381094_147381095GC>AA	uc001epu.1	+	2	1075_1076	c.1012_1013GC>AA	c.(1012-1014)GCA>AAA	p.A338K		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	338	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GGGGCCGCCTGCAGAGGAGGGA	0.653													4	5					0	0	0	0
IQGAP3	128239	broad.mit.edu	37	1	156518471	156518471	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:156518471A>T	uc001fpf.2	-	17	1970	c.1895T>A	c.(1894-1896)TTG>TAG	p.L632*		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	632					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGGGTTCCTCAACACCCGCTC	0.597													11	48					0	0	0	0
CCDC19	25790	broad.mit.edu	37	1	159842919	159842919	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:159842919C>T	uc001fui.2	-	11	1410	c.1392G>A	c.(1390-1392)GAG>GAA	p.E464E	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Silent_p.E379E|CCDC19_uc001ful.2_Silent_p.E379E	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	464	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			CCTTTTTCTCCTCCTCCAGCC	0.587													16	31					0	0	0	0
RABIF	5877	broad.mit.edu	37	1	202850116	202850116	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:202850116G>A	uc001gyl.2	-	2	399	c.362C>T	c.(361-363)TCC>TTC	p.S121F		NM_002871	NP_002862	P47224	MSS4_HUMAN	RAB-interacting factor	121					cellular membrane fusion|protein transport|small GTPase mediated signal transduction		guanyl-nucleotide exchange factor activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(75;0.166)			TTACTCATGGGAAACTCGTTC	0.478													18	81					0	0	0	0
KMO	8564	broad.mit.edu	37	1	241729888	241729888	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:241729888C>T	uc009xgp.2	+	9	850	c.785C>T	c.(784-786)CCG>CTG	p.P262L	KMO_uc001hyy.2_Missense_Mutation_p.P262L|KMO_uc009xgo.1_Missense_Mutation_p.P262L	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	262					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			AAATACTTTCCGGATGCCATC	0.353													10	69					0	0	0	0
OR2M3	127062	broad.mit.edu	37	1	248366497	248366497	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr1:248366497C>G	uc010pzg.1	+	1	128	c.128C>G	c.(127-129)TCT>TGT	p.S43C		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATGGGAAACTCTGTCATGGTT	0.547													80	210					0	0	0	0
FBXO18	84893	broad.mit.edu	37	10	5948284	5948284	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:5948284C>T	uc001iis.2	+	3	537	c.442C>T	c.(442-444)CCA>TCA	p.P148S	FBXO18_uc001iir.2_Missense_Mutation_p.P74S|FBXO18_uc009xig.2_Missense_Mutation_p.P74S|FBXO18_uc001iit.2_Missense_Mutation_p.P199S	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	148	F-box.				DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						TAAGAAAGCTCCACGGCACCA	0.597													5	35					0	0	0	0
ITGA8	8516	broad.mit.edu	37	10	15760779	15760779	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:15760779G>T	uc001ioc.1	-	2	329	c.329C>A	c.(328-330)CCG>CAG	p.P110Q	ITGA8_uc010qcb.1_Missense_Mutation_p.P110Q	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	110	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GGTGTCAAACGGTATCTGCCT	0.597													36	78					4.3181e-19	1.16997e-18	1	0
CUBN	8029	broad.mit.edu	37	10	16918894	16918894	+	Splice_Site	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:16918894A>T	uc001ioo.2	-	57	9158	c.9106_splice	c.e57+1	p.S3036_splice	CUBN_uc009xjq.1_Splice_Site|CUBN_uc009xjr.1_Splice_Site_p.S392_splice	NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor						cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATGGCTACTCACAGATTATCC	0.418													10	53					0	0	0	0
ZNF365	22891	broad.mit.edu	37	10	64159517	64159517	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:64159517A>G	uc001jly.3	+	5	1300	c.1238A>G	c.(1237-1239)AAA>AGA	p.K413R	ZNF365_uc001jmb.3_Intron|ZNF365_uc001jmc.2_Intron|ZNF365_uc001jlz.3_Missense_Mutation_p.K398R|ZNF365_uc001jma.3_RNA	NM_014951	NP_055766	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform A	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					ATGGCTAAAAAAAAGCCAACA	0.517													9	35					0	0	0	0
TBC1D12	23232	broad.mit.edu	37	10	96162460	96162460	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:96162460G>A	uc001kjr.2	+	1	275	c.90G>A	c.(88-90)AGG>AGA	p.R30R		NM_015188	NP_056003	O60347	TBC12_HUMAN	TBC1 domain family, member 12	30						intracellular	Rab GTPase activator activity				0		Colorectal(252;0.0429)				GCCAGGACAGGAAGGTAATCC	0.562													3	5					0	0	0	0
GLRX3	10539	broad.mit.edu	37	10	131973264	131973264	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:131973264C>T	uc001lkm.1	+	10	890	c.868C>T	c.(868-870)CGG>TGG	p.R290W	GLRX3_uc001lkn.1_Missense_Mutation_p.R290W|GLRX3_uc001lko.2_RNA	NM_006541	NP_006532	O76003	GLRX3_HUMAN	glutaredoxin 3	290	Glutaredoxin 2.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity				0		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		TCTTTAGGTTCGGCAAGGATT	0.428													10	53					0	0	0	0
DPYSL4	10570	broad.mit.edu	37	10	134014379	134014379	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:134014379C>T	uc009ybb.2	+	10	1156	c.1002C>T	c.(1000-1002)TGC>TGT	p.C334C		NM_006426	NP_006417	O14531	DPYL4_HUMAN	dihydropyrimidinase-like 4	334					axon guidance|pyrimidine base catabolic process	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			central_nervous_system(2)	2		all_cancers(35;4.33e-08)|all_epithelial(44;6.75e-06)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)|Colorectal(31;0.19)		OV - Ovarian serous cystadenocarcinoma(35;7.21e-05)|Epithelial(32;8.01e-05)|all cancers(32;9.29e-05)|BRCA - Breast invasive adenocarcinoma(275;0.206)		GCGCCCACTGCACCTTCACCA	0.647													6	15					0	0	0	0
OR5A2	219981	broad.mit.edu	37	11	59190241	59190241	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:59190241G>A	uc010rkt.1	-	1	186	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACTGAGGAAGAAGTACATGG	0.493													21	70					0	0	0	0
OR5A1	219982	broad.mit.edu	37	11	59211053	59211053	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:59211053A>G	uc001nnx.1	+	1	412	c.412A>G	c.(412-414)ATC>GTC	p.I138V		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	138	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CTACCCCACTATCATGACCCA	0.542													35	292					0	0	0	0
NPAS4	266743	broad.mit.edu	37	11	66192686	66192686	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:66192686G>A	uc001ohx.1	+	7	2501	c.2325G>A	c.(2323-2325)GGG>GGA	p.G775G	NPAS4_uc010rpc.1_Silent_p.G565G	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	775					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCTATGATGGGTTTACTGATG	0.398													18	42					0	0	0	0
B3GAT1	27087	broad.mit.edu	37	11	134253871	134253871	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr11:134253871C>T	uc001qhq.2	-	4	585	c.324G>A	c.(322-324)ACG>ACA	p.T108T	B3GAT1_uc001qhr.2_Silent_p.T108T|B3GAT1_uc010scv.1_Silent_p.T121T	NM_018644	NP_061114	Q9P2W7	B3GA1_HUMAN	beta-1,3-glucuronyltransferase 1	108	Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.39e-23)|all_epithelial(12;7.17e-17)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|Medulloblastoma(222;0.0125)|all_neural(223;0.0137)|Esophageal squamous(93;0.0559)		Epithelial(10;2.58e-11)|all cancers(11;5.75e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.000879)|Lung(977;0.0864)		CGTGCAGCAGCGTGTTGGCCA	0.716													10	7					0	0	0	0
USP5	8078	broad.mit.edu	37	12	6970679	6970679	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:6970679G>A	uc001qri.3	+	13	1630	c.1571G>A	c.(1570-1572)CGG>CAG	p.R524Q	USP5_uc001qrh.3_Missense_Mutation_p.R524Q	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	524					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						GAACTGGTTCGGGCCCAGGTG	0.607													51	67					0	0	0	0
ATN1	1822	broad.mit.edu	37	12	7046365	7046365	+	Silent	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:7046365C>G	uc001qrw.1	+	5	2172	c.1935C>G	c.(1933-1935)TCC>TCG	p.S645S	ATN1_uc001qrx.1_Silent_p.S645S	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	645					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GAGCCCCGTCCCCGGGGGCCT	0.672													12	47					0	0	0	0
SLC2A14	144195	broad.mit.edu	37	12	7973851	7973851	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:7973851G>A	uc001qtk.2	-	13	1797	c.1004C>T	c.(1003-1005)GCG>GTG	p.A335V	SLC2A14_uc001qtl.2_Missense_Mutation_p.A312V|SLC2A14_uc001qtm.2_Missense_Mutation_p.A312V|SLC2A14_uc010sgg.1_Missense_Mutation_p.A226V|SLC2A14_uc001qtn.2_Missense_Mutation_p.A335V|SLC2A14_uc001qto.2_5'UTR|SLC2A14_uc010sgh.1_Missense_Mutation_p.A350V	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	335	Helical; Name=8; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		AACCACACCCGCGCTGATGGT	0.413													43	122					0	0	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21069131	21069131	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:21069131G>C	uc001rek.2	+	15	2185	c.2059G>C	c.(2059-2061)GAT>CAT	p.D687H	SLCO1B3_uc001rel.2_Missense_Mutation_p.D687H|SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	687	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TGCTGGAACAGATAGTAAAAC	0.348													19	34					0	0	0	0
ABCC9	10060	broad.mit.edu	37	12	21958120	21958120	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:21958120C>A	uc001rfi.1	-	38	4658	c.4638G>T	c.(4636-4638)ATG>ATT	p.M1546I	ABCC9_uc001rfh.2_Intron|ABCC9_uc001rfj.1_Missense_Mutation_p.M1510I|ABCC9_uc001rfg.2_Intron	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1546	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.R1546H(1)		ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACTTGTTGGTCATCACCAAAG	0.438													25	56					4.26978e-12	1.09056e-11	1	0
SLC4A8	9498	broad.mit.edu	37	12	51853842	51853842	+	Silent	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:51853842G>T	uc001rys.1	+	8	1141	c.963G>T	c.(961-963)CTG>CTT	p.L321L	SLC4A8_uc010sni.1_Silent_p.L268L|SLC4A8_uc001rym.2_Silent_p.L268L|SLC4A8_uc001ryn.2_Silent_p.L268L|SLC4A8_uc001ryo.2_Silent_p.L268L|SLC4A8_uc001ryp.1_Silent_p.L268L|SLC4A8_uc010snj.1_Silent_p.L348L|SLC4A8_uc001ryq.3_Silent_p.L321L|SLC4A8_uc001ryr.2_Silent_p.L321L|SLC4A8_uc010snk.1_Silent_p.L268L	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	321	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TTGTGAGGCTGTCTCCAGCTG	0.438													36	179					6.03168e-27	1.67966e-26	1	0
KRT83	3889	broad.mit.edu	37	12	52709747	52709747	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:52709747T>A	uc001saf.2	-	7	1255	c.1192A>T	c.(1192-1194)ATG>TTG	p.M398L		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	398	Rod.|Coil 2.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TTGGAGTTCATCACCTCCTGG	0.637													20	95					0	0	0	0
LRP1	4035	broad.mit.edu	37	12	57532268	57532268	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:57532268T>C	uc001snd.2	+	2	560	c.94T>C	c.(94-96)TTT>CTT	p.F32L	LRP1_uc010sre.1_Missense_Mutation_p.F32L|LRP1_uc001snb.2_Missense_Mutation_p.F32L|LRP1_uc001snc.1_Missense_Mutation_p.F32L	NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	32	LDL-receptor class A 1.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCCAAGCAGTTTGCCTGCAG	0.527													28	126					0	0	0	0
NR1H4	9971	broad.mit.edu	37	12	100955674	100955674	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:100955674G>T	uc001tht.1	+	8	1148	c.1120G>T	c.(1120-1122)GAA>TAA	p.E374*	NR1H4_uc001thp.1_Nonsense_Mutation_p.E360*|NR1H4_uc001thq.1_Nonsense_Mutation_p.E364*|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Nonsense_Mutation_p.E364*|NR1H4_uc010svk.1_Nonsense_Mutation_p.E313*|NR1H4_uc001ths.1_Nonsense_Mutation_p.E370*	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	374	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TATCTCTGATGAATATATAAC	0.333													7	33					2.7689e-08	6.64867e-08	1	0
APPL2	55198	broad.mit.edu	37	12	105600878	105600878	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:105600878C>T	uc001tlf.1	-	8	800	c.582G>A	c.(580-582)ATG>ATA	p.M194I	APPL2_uc010swt.1_Missense_Mutation_p.M151I|APPL2_uc001tlg.1_5'UTR|APPL2_uc010swu.1_Missense_Mutation_p.M200I|APPL2_uc009zuq.2_Missense_Mutation_p.M151I	NM_018171	NP_060641	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH	194	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			upper_aerodigestive_tract(1)	1						CCATCATGGCCATTTGCTTTC	0.597													13	68					0	0	0	0
MYO1H	283446	broad.mit.edu	37	12	109849746	109849746	+	Silent	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:109849746G>C	uc010sxn.1	+	13	1410	c.1410G>C	c.(1408-1410)CTG>CTC	p.L470L		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						myosin complex	motor activity				0						TGAGTTTCCTGGAGAAATTGG	0.433													3	10					0	0	0	0
SDSL	113675	broad.mit.edu	37	12	113872019	113872019	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:113872019C>A	uc001tvi.2	+	6	645	c.435C>A	c.(433-435)CCC>CCA	p.P145P	SDSL_uc009zwh.2_Silent_p.P145P	NM_138432	NP_612441	Q96GA7	SDSL_HUMAN	serine dehydratase-like	145					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	TTGACCACCCCCTAATATGGT	0.423													26	115					2.48779e-11	6.27425e-11	1	0
PITPNM2	57605	broad.mit.edu	37	12	123482024	123482024	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:123482024C>T	uc001uej.1	-	10	1459	c.1320G>A	c.(1318-1320)GGG>GGA	p.G440G	PITPNM2_uc001uek.1_Silent_p.G440G	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	440					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		AGCTGGGGTCCCCGGCGCCTG	0.662													28	87					0	0	0	0
PXMP2	5827	broad.mit.edu	37	12	133266864	133266864	+	Silent	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr12:133266864A>T	uc001ukt.2	+	2	203	c.138A>T	c.(136-138)GCA>GCT	p.A46A	POLE_uc001uks.1_5'Flank|POLE_uc010tbq.1_5'Flank|POLE_uc009zyu.1_5'Flank|PGAM5_uc010tbr.1_RNA	NM_018663	NP_061133	Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	46	Helical; (Potential).					integral to membrane|peroxisomal membrane	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		TTTTGTCAGCACTTGGGAACT	0.512													17	72					0	0	0	0
FAM123A	219287	broad.mit.edu	37	13	25743972	25743972	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:25743972G>T	uc001uqb.2	-	1	1886	c.1786C>A	c.(1786-1788)CTG>ATG	p.L596M	FAM123A_uc001uqa.2_Missense_Mutation_p.L477M|FAM123A_uc001uqc.2_Missense_Mutation_p.L477M	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	596										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GGTGTTCGCAGTGGACAGGTG	0.572													60	58					1.53582e-20	4.18956e-20	1	0
BRCA2	675	broad.mit.edu	37	13	32907432	32907432	+	Missense_Mutation	SNP	C	T	T	rs80358469		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:32907432C>T	uc001uub.1	+	10	2044	c.1817C>T	c.(1816-1818)CCG>CTG	p.P606L	BRCA2_uc001uua.1_Missense_Mutation_p.P483L	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	606					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAAAAAATACCGAAAGACCAA	0.318			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			6	33					0	0	0	0
LMO7	4008	broad.mit.edu	37	13	76393647	76393647	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:76393647C>T	uc001vjv.2	+	10	2244	c.1484C>T	c.(1483-1485)ACG>ATG	p.T495M	LMO7_uc010thv.1_Missense_Mutation_p.T446M|LMO7_uc001vjt.1_Missense_Mutation_p.T394M|LMO7_uc010thw.1_Missense_Mutation_p.T345M|LMO7_uc001vjw.1_Missense_Mutation_p.T401M	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	780						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		AGCTCTAAGACGTTTAAGGAA	0.388													16	38					0	0	0	0
SCEL	8796	broad.mit.edu	37	13	78183252	78183252	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:78183252G>T	uc001vki.2	+	21	1447	c.1277G>T	c.(1276-1278)GGG>GTG	p.G426V	SCEL_uc001vkj.2_Missense_Mutation_p.G406V|SCEL_uc010thx.1_Missense_Mutation_p.G384V	NM_144777	NP_659001	O95171	SCEL_HUMAN	sciellin isoform 1	426	9.|16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			ovary(4)|breast(1)	5		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		AGTACTGAAGGGTAAGATTTA	0.313													10	17					1.58986e-06	3.7066e-06	1	0
FGF14	2259	broad.mit.edu	37	13	102375271	102375271	+	Silent	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr13:102375271G>C	uc001vpe.2	-	5	654	c.654C>G	c.(652-654)GTC>GTG	p.V218V	FGF14_uc001vpf.2_Silent_p.V223V|FGF14_uc001vpd.1_5'Flank	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	218					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAGGCTTCGGGACCGTTTCCC	0.478													45	41					0	0	0	0
TOX4	9878	broad.mit.edu	37	14	21957421	21957421	+	Silent	SNP	T	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:21957421T>C	uc001waz.2	+	5	772	c.669T>C	c.(667-669)CCT>CCC	p.P223P	TOX4_uc001way.2_Silent_p.P93P|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Silent_p.P200P|TOX4_uc010tlv.1_Silent_p.P93P	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	223	HMG box.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		CTAATGAACCTCAGAAACCAG	0.443													58	72					0	0	0	0
KCNH5	27133	broad.mit.edu	37	14	63246619	63246619	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:63246619T>A	uc001xfx.2	-	10	1897	c.1846A>T	c.(1846-1848)ATC>TTC	p.I616F	KCNH5_uc001xfy.2_Intron|KCNH5_uc001xfz.1_Missense_Mutation_p.I558F	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	616	cNMP.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTCCAGAAGATGTCTCCAAAT	0.423													14	31					0	0	0	0
AKAP5	9495	broad.mit.edu	37	14	64936395	64936395	+	Nonstop_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:64936395G>C	uc001xhd.3	+	2	1661	c.1283G>C	c.(1282-1284)TGA>TCA	p.*428S	ZBTB25_uc001xhc.2_Intron	NM_004857	NP_004848	P24588	AKAP5_HUMAN	A-kinase anchor protein 5	428					energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding				0				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		CTTCTACAGTGACTTACTCTC	0.343													11	65					0	0	0	0
YLPM1	56252	broad.mit.edu	37	14	75264441	75264441	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:75264441G>A	uc001xqj.3	+	5	2565	c.2441G>A	c.(2440-2442)CGG>CAG	p.R814Q	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	619					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ATGATTCCCCGGGGGCCAGCA	0.532													11	36					0	0	0	0
Unknown	0	broad.mit.edu	37	15	22472949	22472949	+	RNA	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:22472949C>A	uc001yuj.1	-	2		c.322G>T								Homo sapiens IGH mRNA for immunoglobulin heavy chain VHDJ region, partial cds, clone:H6.																		GCCCTGTCCGCGGCGGTCACA	0.602													28	385					7.01153e-11	1.74635e-10	1	0
GOLGA9P	283796	broad.mit.edu	37	15	23261779	23261779	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:23261779G>A	uc001yvh.1	+	11	1190	c.648G>A	c.(646-648)CCG>CCA	p.P216P	uc001yvl.2_5'Flank	NR_024074				RecName: Full=Putative golgin subfamily A member 6-like protein 11;												0						CCTTGCCCCCGGAGCCCCCAG	0.567													22	67					0	0	0	0
HERC2	8924	broad.mit.edu	37	15	28491924	28491924	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:28491924C>T	uc001zbj.2	-	22	3461	c.3355G>A	c.(3355-3357)GCG>ACG	p.A1119T		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1119					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCCACCTCCGCGAAGTGCCGC	0.488													14	47					0	0	0	0
VPS39	23339	broad.mit.edu	37	15	42470746	42470746	+	Missense_Mutation	SNP	A	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:42470746A>C	uc001zpd.2	-	10	925	c.774T>G	c.(772-774)ATT>ATG	p.I258M	VPS39_uc001zpc.2_Missense_Mutation_p.I247M	NM_015289	NP_056104	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39	258	CNH.				protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			ovary(1)|pancreas(1)|skin(1)	3		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		GCAACACTGCAATGATGTAGG	0.478													10	60					0	0	0	0
CATSPER2	117155	broad.mit.edu	37	15	43927557	43927557	+	Splice_Site	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:43927557C>G	uc001zsh.2	-	10	1393	c.1178_splice	c.e10+1	p.S393_splice	STRC_uc010udz.1_5'Flank|CATSPER2_uc010bdm.2_Splice_Site|CATSPER2_uc001zsi.2_Splice_Site_p.R393_splice|CATSPER2_uc001zsj.2_Splice_Site_p.R393_splice	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		ATACTCCTAACCTGTCCTCTA	0.358											OREG0003957	type=REGULATORY REGION|Gene=AK093318|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	23	298					0	0	0	0
CYP1A2	1544	broad.mit.edu	37	15	75047386	75047386	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:75047386G>T	uc002ayr.1	+	7	1572	c.1508G>T	c.(1507-1509)CGC>CTC	p.R503L		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	503					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	AAGCACGCCCGCTGTGAACAT	0.627													7	34					0.00307968	0.00660402	1	0
GOLGA6L5	374650	broad.mit.edu	37	15	85055894	85055894	+	RNA	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:85055894G>A	uc002bkm.2	-	6		c.666C>T				NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						TCCTGTTCACGTAGCCTCTCC	0.537													5	13					0	0	0	0
GOLGA6L5	374650	broad.mit.edu	37	15	85056021	85056021	+	RNA	SNP	T	C	C	rs1062001		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr15:85056021T>C	uc002bkm.2	-	6		c.539A>G				NR_003246				Homo sapiens cDNA FLJ33459 fis, clone BRAMY2000585.												0						GTAGCTGCTCTACCTTAGATG	0.502													4	26					0	0	0	0
Unknown	0	broad.mit.edu	37	16	66940	66940	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:66940G>A	uc002cfg.1	-	5	1355	c.696C>T	c.(694-696)AGC>AGT	p.S232S		NM_182905	NP_878908			WAS protein family homolog 1																		GCTCTCTCTTGCTGATGGACA	0.597													4	41					0	0	0	0
PLK1	5347	broad.mit.edu	37	16	23700835	23700835	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:23700835C>T	uc002dlz.1	+	9	1499	c.1446C>T	c.(1444-1446)TTC>TTT	p.F482F		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	482					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		TTAAATATTTCCGCAATTACA	0.552													34	66					0	0	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53675283	53675283	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:53675283C>T	uc002ehp.2	-	18	2852	c.2788G>A	c.(2788-2790)GAA>AAA	p.E930K	RPGRIP1L_uc002eho.3_Missense_Mutation_p.E930K|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.E930K|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.E930K|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.E930K	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	930					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				CCTAAGTCTTCAGTTGTTATT	0.403													19	47					0	0	0	0
PDPR	55066	broad.mit.edu	37	16	70164400	70164400	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:70164400G>T	uc002eyf.1	+	7	1639	c.682G>T	c.(682-684)GAT>TAT	p.D228Y	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.D128Y|PDPR_uc002eyg.1_5'Flank	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	228					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		AGTGGAGACCGATAAAGGACA	0.423													7	111					0.000274275	0.000617889	1	0
FTSJD1	55783	broad.mit.edu	37	16	71319208	71319208	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:71319208T>A	uc010cga.2	-	3	1022	c.616A>T	c.(616-618)AAC>TAC	p.N206Y	FTSJD1_uc002ezy.3_Missense_Mutation_p.N206Y|FTSJD1_uc002ezz.3_Missense_Mutation_p.N206Y	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	206						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						TCACCAGTGTTATCTGGACCA	0.428													20	60					0	0	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76496003	76496003	+	Splice_Site	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:76496003G>A	uc002feu.1	+	11	1868	c.1483_splice	c.e11+1	p.G495_splice	CNTNAP4_uc002fev.1_Splice_Site_p.G359_splice|CNTNAP4_uc010chb.1_Splice_Site_p.G422_splice|CNTNAP4_uc002fex.1_Splice_Site_p.G498_splice|CNTNAP4_uc002few.2_Splice_Site_p.G470_splice	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TATTTTGGAGGTAAGAATAGG	0.473													8	25					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578271	7578271	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:7578271T>A	uc002gim.2	-	6	772	c.578A>T	c.(577-579)CAT>CTT	p.H193L	TP53_uc002gig.1_Missense_Mutation_p.H193L|TP53_uc002gih.2_Missense_Mutation_p.H193L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H61L|TP53_uc010cng.1_Missense_Mutation_p.H61L|TP53_uc002gii.1_Missense_Mutation_p.H61L|TP53_uc010cnh.1_Missense_Mutation_p.H193L|TP53_uc010cni.1_Missense_Mutation_p.H193L|TP53_uc002gij.2_Missense_Mutation_p.H193L|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H100L|TP53_uc002gio.2_Missense_Mutation_p.H61L|TP53_uc010vug.1_Missense_Mutation_p.H154L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	193	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> D (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> Y (in sporadic cancers; somatic mutation).|QH -> HN (in a sporadic cancer; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|QH -> HY (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> R (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H193R(67)|p.H193L(31)|p.H193Y(26)|p.H193P(12)|p.0?(7)|p.H193D(7)|p.H193N(4)|p.A189_V197delAPPQHLIRV(4)|p.H193fs*16(3)|p.H193H(2)|p.P191fs*53(2)|p.K164_P219del(1)|p.P191fs*15(1)|p.P191fs*6(1)|p.H100L(1)|p.H61L(1)|p.H193_I195delHLI(1)|p.H193_I195>AP(1)|p.A189fs*53(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCGGATAAGATGCTGAGGAGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			29	19					0	0	0	0
MPRIP	23164	broad.mit.edu	37	17	17078662	17078662	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:17078662G>A	uc002gqu.1	+	19	2701	c.2645G>A	c.(2644-2646)GGG>GAG	p.G882E	MPRIP_uc002gqv.1_Missense_Mutation_p.G882E|MPRIP_uc002gqw.1_Missense_Mutation_p.G637E|MPRIP_uc002gqx.1_Missense_Mutation_p.G1111E|MPRIP_uc002gqy.1_Missense_Mutation_p.G1111E|MPRIP_uc010cpl.1_Intron|MPRIP_uc010cpm.1_Intron	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	882	Potential.					cytoplasm|cytoskeleton	actin binding				0						CTGCTGACTGGGGACGGCGGT	0.632													10	32					0	0	0	0
FLII	2314	broad.mit.edu	37	17	18155350	18155350	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:18155350C>A	uc002gsr.1	-	11	1260	c.1209G>T	c.(1207-1209)GCG>GCT	p.A403A	FLII_uc002gsq.1_Silent_p.A275A|FLII_uc010cpy.1_Silent_p.A392A|FLII_uc010vxn.1_Silent_p.A372A|FLII_uc010vxo.1_Silent_p.A349A|FLII_uc002gss.1_Silent_p.A403A	NM_002018	NP_002009	Q13045	FLII_HUMAN	flightless I homolog	403	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(1)|skin(1)	2	all_neural(463;0.228)					GAGAGGCACCCGCTAGCCGCA	0.637													50	100					4.00472e-15	1.05651e-14	1	0
C17orf66	256957	broad.mit.edu	37	17	34192401	34192401	+	Splice_Site	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:34192401C>A	uc002hke.1	-	3	288	c.139_splice	c.e3-1	p.M47_splice	C17orf66_uc010wck.1_Splice_Site|C17orf66_uc010wcl.1_Splice_Site_p.M47_splice|C17orf66_uc010wcm.1_Splice_Site_p.M13_splice	NM_152781	NP_689994	A2RTY3	CQ066_HUMAN	hypothetical protein LOC256957								binding			breast(2)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		CCTTTGGCATCTGGGGGTTGC	0.562													13	19					0.00136819	0.00298177	1	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	T	T	rs76270529	by1000genomes	TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:39254054A>T	uc010wfo.1	-	1	322	c.283T>A	c.(283-285)TGC>AGC	p.C95S		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].|15.					keratin filament					0						ctggagatgcagcagcTAGGG	0.318													6	52					0	0	0	0
KRT13	3860	broad.mit.edu	37	17	39658642	39658642	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:39658642C>T	uc002hwu.1	-	6	1291	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	KRT13_uc002hwv.1_Missense_Mutation_p.E410K|KRT13_uc002hww.2_Missense_Mutation_p.E303K|KRT13_uc010wfr.1_Missense_Mutation_p.E303K|KRT13_uc010cxo.2_Missense_Mutation_p.E410K|KRT13_uc002hwx.1_Missense_Mutation_p.E398K	NM_153490	NP_705694	P13646	K1C13_HUMAN	keratin 13 isoform a	410	Rod.|Coil 2.				epidermis development	intermediate filament	structural molecule activity			ovary(2)|skin(2)|pancreas(1)	5		Breast(137;0.000286)				TCCTGGCCCTCGAGCAGGCTG	0.493													40	119					0	0	0	0
Unknown	0	broad.mit.edu	37	17	45131451	45131451	+	5'Flank	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:45131451G>T	uc010wkm.1	-						uc010wkn.1_RNA					full-length cDNA clone CS0DC007YA17 of Neuroblastoma Cot 25-normalized of Homo sapiens (human).																		GAAGTACATTGTGAGATACGT	0.468													8	28					5.18039e-06	1.19387e-05	1	0
C17orf71	55181	broad.mit.edu	37	17	57288460	57288460	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:57288460A>T	uc002ixi.2	+	1	1090	c.1048A>T	c.(1048-1050)ATG>TTG	p.M350L		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	350					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					CCCAGTAGGTATGTTGCTGGA	0.522													19	48					0	0	0	0
CCDC40	55036	broad.mit.edu	37	17	78059875	78059875	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:78059875C>A	uc010dht.2	+	14	2336	c.2309C>A	c.(2308-2310)GCG>GAG	p.A770E	CCDC40_uc002jxm.3_Missense_Mutation_p.A553E|CCDC40_uc002jxn.3_Missense_Mutation_p.A166E	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	770	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GATGGCAAGGCGGTCCAGGCC	0.587													6	55					3.59834e-05	8.24533e-05	1	0
ZNF519	162655	broad.mit.edu	37	18	14106335	14106335	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr18:14106335C>A	uc002kst.1	-	3	357	c.204G>T	c.(202-204)CTG>CTT	p.L68L	ZNF519_uc002ksq.1_Intron|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_Intron	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	68	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATATCTTCCCAGTGTTGCTT	0.343													9	47					0.000274275	0.000617889	1	0
C19orf12	83636	broad.mit.edu	37	19	30193700	30193700	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:30193700C>T	uc002nsk.2	-	3	776	c.345G>A	c.(343-345)GAG>GAA	p.E115E	C19orf12_uc002nsj.2_Silent_p.E126E|C19orf12_uc002nsl.2_3'UTR|C19orf12_uc002nsm.2_Intron	NM_031448	NP_113636	Q9NSK7	CS012_HUMAN	hypothetical protein LOC83636 isoform 2	115						integral to membrane					0	Ovarian(5;0.000567)|Breast(6;0.0203)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0435)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.183)			GCTGCAGGGCCTCGCTGCCCA	0.642													10	22					0	0	0	0
ATP4A	495	broad.mit.edu	37	19	36046418	36046418	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:36046418C>T	uc002oal.1	-	14	2110	c.2081G>A	c.(2080-2082)CGC>CAC	p.R694H	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	694	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GGGGTGGGTGCGCAGGGCCTC	0.652													11	30					0	0	0	0
CATSPERG	57828	broad.mit.edu	37	19	38860883	38860883	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:38860883C>A	uc002oih.3	+	28	3285	c.3198C>A	c.(3196-3198)GCC>GCA	p.A1066A	CATSPERG_uc002oig.3_Silent_p.A1026A|CATSPERG_uc002oif.3_Silent_p.A706A|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1066	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CCAAGCGGGCCCTTTTCATCA	0.597													13	18					4.3838e-07	1.04018e-06	1	0
GRLF1	2909	broad.mit.edu	37	19	47503647	47503647	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:47503647G>A	uc010ekv.2	+	6	4202	c.4202G>A	c.(4201-4203)TGG>TAG	p.W1401*		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	1401	Rho-GAP.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		ATCTGCTTCTGGCCCACCTTG	0.542													36	241					0	0	0	0
MIR520A	574467	broad.mit.edu	37	19	54194151	54194151	+	RNA	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:54194151C>A	hsa-mir-520a|MI0003149	+			c.17C>A																				0						CTGTGACCCTCCAGAGGGAAG	0.423													32	153					2.47316e-13	6.43024e-13	1	0
LILRB1	10859	broad.mit.edu	37	19	55143396	55143396	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:55143396C>G	uc002qgj.2	+	6	709	c.369C>G	c.(367-369)ATC>ATG	p.I123M	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.I123M|LILRB1_uc002qgk.2_Missense_Mutation_p.I123M|LILRB1_uc002qgm.2_Missense_Mutation_p.I123M|LILRB1_uc010erq.2_Missense_Mutation_p.I123M|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	123	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GAGCCTACATCAAACCCACCC	0.582										HNSCC(37;0.09)			18	101					0	0	0	0
NLRP2	55655	broad.mit.edu	37	19	55493571	55493571	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:55493571C>T	uc002qij.2	+	6	591	c.505C>T	c.(505-507)CGG>TGG	p.R169W	NLRP2_uc010yfp.1_Missense_Mutation_p.R146W|NLRP2_uc010esn.2_Missense_Mutation_p.R145W|NLRP2_uc010eso.2_Missense_Mutation_p.R166W|NLRP2_uc010esp.2_Missense_Mutation_p.R147W	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	169					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GACGAAGTTCCGGGAGATGTG	0.483													96	162					0	0	0	0
NLRP4	147945	broad.mit.edu	37	19	56370340	56370340	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:56370340A>G	uc002qmd.3	+	3	2003	c.1581A>G	c.(1579-1581)ATA>ATG	p.I527M	NLRP4_uc002qmf.2_Missense_Mutation_p.I452M|NLRP4_uc010etf.2_Missense_Mutation_p.I358M	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	527							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CCCAAGAGATAAAGCAGCAAA	0.428													15	70					0	0	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58596681	58596681	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:58596681G>A	uc002qri.2	-	7	1213	c.904C>T	c.(904-906)CCT>TCT	p.P302S	ZSCAN18_uc002qrj.3_Missense_Mutation_p.P301S|ZSCAN18_uc010yhs.1_Missense_Mutation_p.P166S|ZSCAN18_uc002qrh.2_Missense_Mutation_p.P302S|ZSCAN18_uc010yht.1_Missense_Mutation_p.P358S|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	302					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GGCAGCTCAGGCAGCACCCCC	0.741													8	10					0	0	0	0
MZF1	7593	broad.mit.edu	37	19	59073763	59073763	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:59073763G>A	uc002qto.2	-	6	2442	c.1881C>T	c.(1879-1881)TGC>TGT	p.C627C	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Silent_p.C627C	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	627	C2H2-type 10.				viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		CGCACTCACCGCAGTGGTAGG	0.672													8	14					0	0	0	0
OSR1	130497	broad.mit.edu	37	2	19553023	19553023	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:19553023G>A	uc002rdc.2	-	2	847	c.544C>T	c.(544-546)CGC>TGC	p.R182C		NM_145260	NP_660303	Q8TAX0	OSR1_HUMAN	odd-skipped related 1	182	C2H2-type 1.				chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				GTGAAGTGGCGGCCACAGAAC	0.567													40	66					0	0	0	0
OTOF	9381	broad.mit.edu	37	2	26682979	26682979	+	Silent	SNP	A	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:26682979A>G	uc002rhk.2	-	46	6035	c.5908T>C	c.(5908-5910)TTG>CTG	p.L1970L	OTOF_uc010yla.1_Intron|OTOF_uc002rhh.2_Silent_p.L1203L|OTOF_uc002rhi.2_Silent_p.L1280L|OTOF_uc002rhj.2_Intron	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1970	Poly-Leu.|Helical; (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGGAGCAGCAACAGTTTGAGG	0.607													4	12					0	0	0	0
CTNNA2	1496	broad.mit.edu	37	2	80835424	80835424	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:80835424G>T	uc010ysh.1	+	16	2416	c.2411G>T	c.(2410-2412)GGA>GTA	p.G804V	CTNNA2_uc010yse.1_Missense_Mutation_p.G804V|CTNNA2_uc010ysf.1_Missense_Mutation_p.G804V|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysi.1_Missense_Mutation_p.G436V|CTNNA2_uc010ysj.1_Missense_Mutation_p.G133V	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	804					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						AATCTGGGAGGAGAGCTCATT	0.463													15	30					2.48551e-13	6.43024e-13	1	0
ANKRD20B	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:95522772T>C	uc010fhp.2	-	1		c.49A>G				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						GCGCTCCACCTCCGCGGCGTC	0.682													3	87					0	0	0	0
NCKAP5	344148	broad.mit.edu	37	2	133543010	133543010	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:133543010C>A	uc002ttp.2	-	14	1748	c.1374G>T	c.(1372-1374)GGG>GGT	p.G458G	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	458							protein binding				0						TGCAGGGGCTCCCCAGGTCAG	0.468													8	44					1.26484e-09	3.0927e-09	1	0
PKP4	8502	broad.mit.edu	37	2	159530275	159530275	+	Splice_Site	SNP	T	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:159530275T>G	uc002tzv.2	+	18	3269	c.3009_splice	c.e18+2	p.K1003_splice	PKP4_uc002tzw.2_Splice_Site_p.K1003_splice|PKP4_uc002tzx.2_Splice_Site_p.K660_splice|PKP4_uc002uaa.2_Splice_Site_p.K855_splice|uc002uab.1_Intron|PKP4_uc002uac.2_Splice_Site_p.K184_splice|PKP4_uc002uad.2_Splice_Site|PKP4_uc002uae.1_Splice_Site_p.K90_splice	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a						cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						TATAAAAAGGTAACCTACAAG	0.388										HNSCC(62;0.18)			19	34					0	0	0	0
TANK	10010	broad.mit.edu	37	2	162087916	162087916	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:162087916A>G	uc002ubr.1	+	7	1113	c.955A>G	c.(955-957)ATC>GTC	p.I319V	TANK_uc002ubs.2_Missense_Mutation_p.I319V	NM_004180	NP_004171	Q92844	TANK_HUMAN	TRAF interacting protein TANK isoform a	319						cytosol	metal ion binding|protein binding			ovary(1)	1						AAACACTTGTATCAGGACAAC	0.403													19	57					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179428334	179428334	+	Silent	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:179428334G>T	uc010zfg.1	-	275	75045	c.74821C>A	c.(74821-74823)CGA>AGA	p.R24941R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.R18636R|TTN_uc010zfi.1_Silent_p.R18569R|TTN_uc010zfj.1_Silent_p.R18444R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25868							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCTTATCTCGTTTTTCAAGA	0.463													43	129					1.00001e-27	2.80421e-27	1	0
TTN	7273	broad.mit.edu	37	2	179612977	179612977	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:179612977G>A	uc002unb.2	-	46	14374	c.14150C>T	c.(14149-14151)ACT>ATT	p.T4717I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	826							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAAGATCAGTTTTTAAAAT	0.328													12	53					0	0	0	0
ASNSD1	54529	broad.mit.edu	37	2	190530996	190530996	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr2:190530996G>T	uc002uqt.2	+	4	572	c.138G>T	c.(136-138)CAG>CAT	p.Q46H		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	46	Glutamine amidotransferase type-2.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			TTAACTACCAGTGTTTATTTT	0.378													32	85					8.16721e-17	2.18337e-16	1	0
MMP24	10893	broad.mit.edu	37	20	33855127	33855127	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr20:33855127G>A	uc002xbu.2	+	6	1102	c.1099G>A	c.(1099-1101)GGG>AGG	p.G367R	EDEM2_uc010zuv.1_Intron	NM_006690	NP_006681	Q9Y5R2	MMP24_HUMAN	matrix metalloproteinase 24 preproprotein	367	Extracellular (Potential).				proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GCCGCCCCTCGGGGACCGGCC	0.637													4	12					0	0	0	0
RBM11	54033	broad.mit.edu	37	21	15599316	15599316	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599316G>C	uc002yjo.3	+	5	590	c.548G>C	c.(547-549)GGA>GCA	p.G183A	RBM11_uc002yjn.3_Missense_Mutation_p.G69A|RBM11_uc002yjp.3_Missense_Mutation_p.G69A	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	183							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTGAGGCTGGACCCAGCTCA	0.463													5	303					0	0	0	0
RBM11	54033	broad.mit.edu	37	21	15599442	15599442	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599442G>C	uc002yjo.3	+	5	716	c.674G>C	c.(673-675)GGA>GCA	p.G225A	RBM11_uc002yjn.3_Missense_Mutation_p.G111A|RBM11_uc002yjp.3_Missense_Mutation_p.G111A	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	225							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CTTGAGGCTGGACCCAGCTCA	0.423													42	229					0	0	0	0
RBM11	54033	broad.mit.edu	37	21	15599531	15599531	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599531G>A	uc002yjo.3	+	5	805	c.763G>A	c.(763-765)GAT>AAT	p.D255N	RBM11_uc002yjn.3_Missense_Mutation_p.D141N|RBM11_uc002yjp.3_Missense_Mutation_p.D141N	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	255							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GCAAACAAGTGATAGTGATAG	0.388													22	130					0	0	0	0
RBM11	54033	broad.mit.edu	37	21	15599567	15599567	+	Nonsense_Mutation	SNP	G	T	T	rs61733445		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599567G>T	uc002yjo.3	+	5	841	c.799G>T	c.(799-801)GAA>TAA	p.E267*	RBM11_uc002yjn.3_Nonsense_Mutation_p.E153*|RBM11_uc002yjp.3_Nonsense_Mutation_p.E153*	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	267							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		CAGAGGCAACGAATGTAGCCA	0.358													15	86					2.98522e-18	8.03404e-18	1	0
RBM11	54033	broad.mit.edu	37	21	15599599	15599599	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:15599599G>A	uc002yjo.3	+	5	873	c.831G>A	c.(829-831)AAG>AAA	p.K277K	RBM11_uc002yjn.3_Silent_p.K163K|RBM11_uc002yjp.3_Silent_p.K163K	NM_144770	NP_658983	P57052	RBM11_HUMAN	RNA binding motif protein 11	277							nucleotide binding|RNA binding				0				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		AGTCTAAGAAGAAGAAAAGAT	0.328													12	62					0	0	0	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744390	31744390	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr21:31744390G>T	uc002ynz.3	-	1	168	c.142C>A	c.(142-144)CTG>ATG	p.L48M		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	48	1.|5 X 10 AA approximate repeats.					intermediate filament					0						GAGGAACCCAGCTGGCAGGTG	0.602													25	72					1.64293e-13	4.30599e-13	1	0
CELSR1	9620	broad.mit.edu	37	22	46860111	46860111	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr22:46860111G>A	uc003bhw.1	-	2	3676	c.3676C>T	c.(3676-3678)CTC>TTC	p.L1226F		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1226	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TCCACGAAGAGGGCCAGCAGC	0.602													12	39					0	0	0	0
ZBED4	9889	broad.mit.edu	37	22	50279257	50279257	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr22:50279257C>T	uc003bix.2	+	2	2417	c.1947C>T	c.(1945-1947)TAC>TAT	p.Y649Y		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	649						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		AGAAGTTTTACGATTCTCACC	0.493													16	48					0	0	0	0
SHANK3	85358	broad.mit.edu	37	22	51137137	51137137	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr22:51137137C>T	uc003bne.1	+	13	1566	c.1566C>T	c.(1564-1566)GGC>GGT	p.G522G	SHANK3_uc003bnf.1_5'UTR	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	522										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		TTGGGGAGGGCGGTTTCTGGG	0.652													8	25					0	0	0	0
ARPP21	10777	broad.mit.edu	37	3	35732493	35732493	+	Nonsense_Mutation	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:35732493A>T	uc003cgb.2	+	9	946	c.682A>T	c.(682-684)AGA>TGA	p.R228*	ARPP21_uc003cga.2_Nonsense_Mutation_p.R228*|ARPP21_uc011axy.1_Nonsense_Mutation_p.R228*|ARPP21_uc003cgf.2_Nonsense_Mutation_p.R64*	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	228						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAGCAGCACCAGAATGTAAGC	0.368													9	68					0	0	0	0
CX3CR1	1524	broad.mit.edu	37	3	39306963	39306963	+	Silent	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:39306963C>G	uc003cjl.2	-	2	1130	c.1038G>C	c.(1036-1038)ACG>ACC	p.T346T		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	346	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CTCCATCACTCGTGTGGTAAG	0.488													43	84					0	0	0	0
PTH1R	5745	broad.mit.edu	37	3	46935398	46935398	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:46935398T>G	uc003cqm.2	+	4	280	c.77T>G	c.(76-78)GTG>GGG	p.V26G	PTH1R_uc003cqn.2_Missense_Mutation_p.V26G	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	26						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GCTTGGCAGGTGGATGCAGAT	0.572									Ollier_disease_/_Maffuci_syndrome				6	27					0	0	0	0
ACY1	95	broad.mit.edu	37	3	52012073	52012073	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:52012073G>T	uc011bea.1	+	2	366	c.111G>T	c.(109-111)AGG>AGT	p.R37S	ABHD14B_uc003dcn.2_Intron|ABHD14A_uc010hlz.2_Missense_Mutation_p.V86L|ABHD14A_uc003dco.2_Missense_Mutation_p.V86L	NM_000666	NP_000657	Q03154	ACY1_HUMAN	aminoacylase 1	Error:Variant_position_missing_in_Q03154_after_alignment					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	TTACCGCGAGGTGCTCCCACT	0.617													6	13					0.00198382	0.00427694	1	0
OR5H2	79310	broad.mit.edu	37	3	98001793	98001793	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:98001793G>T	uc003dsj.1	+	1	62	c.62G>T	c.(61-63)GGA>GTA	p.G21V		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G21E(1)		ovary(3)	3						GTTCTCACAGGACTTACATAT	0.413													40	172					9.39024e-22	2.5791e-21	1	0
MYH15	22989	broad.mit.edu	37	3	108211974	108211974	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:108211974C>A	uc003dxa.1	-	9	879	c.822G>T	c.(820-822)GTG>GTT	p.V274V		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	274	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						TATCAATGTCCACAGATGACA	0.313													8	49					5.18039e-06	1.19387e-05	1	0
ARGFX	503582	broad.mit.edu	37	3	121304883	121304883	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:121304883C>A	uc003eef.2	+	5	479	c.384C>A	c.(382-384)AAC>AAA	p.N128K		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	128	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		GGTTCAGGAACCGGCGATTCA	0.502													8	57					0.000274275	0.000617889	1	0
SLC15A2	6565	broad.mit.edu	37	3	121643791	121643791	+	Splice_Site	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:121643791G>T	uc003eep.2	+	13	1189	c.1036_splice	c.e13-1	p.V346_splice	SLC15A2_uc011bjn.1_Splice_Site_p.V315_splice	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a						protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TGGTGTTACAGGTTCTAAATC	0.393													30	171					7.01153e-11	1.74635e-10	1	0
SLC7A14	57709	broad.mit.edu	37	3	170219002	170219002	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:170219002C>G	uc003fgz.2	-	3	753	c.437G>C	c.(436-438)GGC>GCC	p.G146A	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	146						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GGCCGCAGTGCCAATCAGGTA	0.557													8	36					0	0	0	0
PIK3CA	5290	broad.mit.edu	37	3	178948136	178948136	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr3:178948136G>A	uc003fjk.2	+	20	3065	c.2908G>A	c.(2908-2910)GAA>AAA	p.E970K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	970	PI3K/PI4K.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E970K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGGAGCCCAAGAATGCACAAA	0.338		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			32	55					0	0	0	0
ZNF141	7700	broad.mit.edu	37	4	367208	367208	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:367208A>G	uc003gaa.2	+	5	1160	c.982A>G	c.(982-984)AAA>GAA	p.K328E	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	328	C2H2-type 6.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						AACCCTTACTAAACATAAGAG	0.378													29	65					0	0	0	0
HTT	3064	broad.mit.edu	37	4	3134446	3134446	+	Silent	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:3134446A>T	uc011bvq.1	+	18	2545	c.2400A>T	c.(2398-2400)ACA>ACT	p.T800T		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	798					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GAACCCTCACAGGTAACGGCC	0.468													44	106					0	0	0	0
ADRA2C	152	broad.mit.edu	37	4	3768967	3768967	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:3768967C>T	uc003ghm.2	+	1	672	c.634C>T	c.(634-636)CTG>TTG	p.L212L	ADRA2C_uc010icx.2_Silent_p.L212L	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	212	Helical; Name=5; (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CTGGTACATCCTGTCCTCCTG	0.682													7	18					0	0	0	0
BOD1L	259282	broad.mit.edu	37	4	13602037	13602037	+	Missense_Mutation	SNP	T	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:13602037T>G	uc003gmz.1	-	10	6604	c.6487A>C	c.(6487-6489)AAG>CAG	p.K2163Q	BOD1L_uc010idr.1_Missense_Mutation_p.K1500Q	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2163							DNA binding			ovary(5)|breast(1)	6						TCAGCACACTTGATGGTTGTT	0.507													22	59					0	0	0	0
PHOX2B	8929	broad.mit.edu	37	4	41747863	41747863	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:41747863G>C	uc003gwf.3	-	3	1266	c.906C>G	c.(904-906)AAC>AAG	p.N302K		NM_003924	NP_003915	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	302					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|lung(2)|ovary(2)|central_nervous_system(1)	12						CTTTGGCACCGTTGGGTCTTT	0.557			Mis|F		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				27	65					0	0	0	0
KCTD8	386617	broad.mit.edu	37	4	44177041	44177041	+	Silent	SNP	T	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:44177041T>A	uc003gwu.2	-	2	1472	c.1188A>T	c.(1186-1188)GCA>GCT	p.A396A		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	396						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						ATTGTACAGGTGCTTTTTTAG	0.493										HNSCC(17;0.042)			41	216					0	0	0	0
FRAS1	80144	broad.mit.edu	37	4	79284715	79284715	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:79284715G>T	uc003hlb.2	+	21	2911	c.2471G>T	c.(2470-2472)GGG>GTG	p.G824V	FRAS1_uc003hkw.2_Missense_Mutation_p.G824V	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	824	FU 9.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CACAACACTGGGAGCATCTGC	0.582													13	18					1.05317e-09	2.59093e-09	1	0
PTPN13	5783	broad.mit.edu	37	4	87705662	87705662	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:87705662A>T	uc003hpz.2	+	38	6549	c.6069A>T	c.(6067-6069)AAA>AAT	p.K2023N	PTPN13_uc003hpy.2_Missense_Mutation_p.K2028N|PTPN13_uc003hqa.2_Missense_Mutation_p.K2004N|PTPN13_uc003hqb.2_Missense_Mutation_p.K1832N|PTPN13_uc003hqc.1_Missense_Mutation_p.K389N	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2023						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CCAAAGGAAAATGTTCTACTT	0.353													3	27					0	0	0	0
LOC285501	285501	broad.mit.edu	37	4	178911715	178911715	+	RNA	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:178911715G>A	uc010iru.2	+	6		c.849G>A				NR_028342				Homo sapiens cDNA clone IMAGE:4828874.												0		all_lung(41;6.03e-08)|Lung NSC(41;4.26e-07)|Breast(14;0.00066)|Melanoma(52;0.00168)|Prostate(90;0.0129)|all_hematologic(60;0.0202)|Renal(120;0.0246)|Colorectal(36;0.0508)|Hepatocellular(41;0.236)		all cancers(43;9.24e-25)|Epithelial(43;6.28e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.29e-10)|LUSC - Lung squamous cell carcinoma(1;2.61e-05)|Lung(1;3.22e-05)|GBM - Glioblastoma multiforme(59;0.000185)|Colorectal(24;0.000244)|STAD - Stomach adenocarcinoma(60;0.000777)|COAD - Colon adenocarcinoma(29;0.000884)		CCCAACATTCGGGACTTTGTG	0.408													7	41					0	0	0	0
SDHAP3	728609	broad.mit.edu	37	5	1576408	1576408	+	RNA	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:1576408C>T	uc011cmd.1	-	2		c.321G>A			SDHAP3_uc011cme.1_RNA					Homo sapiens cDNA FLJ58919 complete cds, moderately similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial precursor (EC1.3.5.1).												0						CCACCAGGTCCGTGTTCCAGA	0.637													6	20					0	0	0	0
KIAA0947	23379	broad.mit.edu	37	5	5486871	5486871	+	Silent	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:5486871A>T	uc003jdm.3	+	18	6780	c.6558A>T	c.(6556-6558)CCA>CCT	p.P2186P		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2186										ovary(1)|central_nervous_system(1)	2						AAGGATTTCCATCTGCTGTGA	0.323													3	8					0	0	0	0
DNAH5	1767	broad.mit.edu	37	5	13708445	13708445	+	Splice_Site	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:13708445C>T	uc003jfd.2	-	76	13168	c.13126_splice	c.e76-1	p.V4376_splice	DNAH5_uc003jfc.2_Splice_Site_p.V544_splice	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTCTTTTACCTGCCATGGAG	0.463									Kartagener_syndrome				31	62					0	0	0	0
SLC38A9	153129	broad.mit.edu	37	5	54968452	54968452	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:54968452G>A	uc003jqf.2	-	4	386	c.185C>T	c.(184-186)TCT>TTT	p.S62F	SLC38A9_uc003jqd.2_5'UTR|SLC38A9_uc010ivx.2_Missense_Mutation_p.S35F|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Intron	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	62					amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				GTTCATGGCAGAGGCATGGTC	0.413													16	61					0	0	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166108	140166108	+	Missense_Mutation	SNP	A	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:140166108A>T	uc003lhb.2	+	1	233	c.233A>T	c.(232-234)AAT>ATT	p.N78I	PCDHA1_uc003lha.2_Missense_Mutation_p.N78I|PCDHA1_uc003lgz.2_Missense_Mutation_p.N78I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	78	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGAGGTAAATCTGCAGAAT	0.597													37	127					0	0	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222763	140222763	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:140222763C>A	uc003lhs.2	+	1	1857	c.1857C>A	c.(1855-1857)CGC>CGA	p.R619R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.R619R	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	619	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCCCTCGCATCCCGTTCC	0.672													48	111					1.61863e-15	4.29847e-15	1	0
PCDHB2	56133	broad.mit.edu	37	5	140475707	140475707	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:140475707G>C	uc003lil.2	+	1	1471	c.1333G>C	c.(1333-1335)GAC>CAC	p.D445H	PCDHB2_uc003lim.1_Missense_Mutation_p.D106H	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	445	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTGGTCTCCGACGTCAATGA	0.607													55	136					0	0	0	0
C5orf41	153222	broad.mit.edu	37	5	172517447	172517447	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:172517447G>A	uc003mch.2	+	4	569	c.265G>A	c.(265-267)GAA>AAA	p.E89K	C5orf41_uc003mcg.2_Missense_Mutation_p.E89K|C5orf41_uc003mcf.2_Missense_Mutation_p.E89K|C5orf41_uc011dfd.1_Missense_Mutation_p.E89K	NM_153607	NP_705835	Q8IUR6	CE041_HUMAN	luman-recruiting factor	89							protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CTCAAACTGGGAACAGTGGGA	0.413													29	34					0	0	0	0
RGS14	10636	broad.mit.edu	37	5	176794768	176794768	+	Silent	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr5:176794768G>T	uc003mgf.2	+	7	863	c.681G>T	c.(679-681)GGG>GGT	p.G227G	RGS14_uc003mgg.1_Silent_p.G74G|RGS14_uc003mgh.2_Silent_p.G74G|RGS14_uc003mgi.2_5'UTR	NM_006480	NP_006471	O43566	RGS14_HUMAN	regulator of G-protein signalling 14	227					chromosome segregation|long-term memory|long-term synaptic potentiation|negative regulation of ERK1 and ERK2 cascade|negative regulation of MAP kinase activity|negative regulation of synaptic plasticity|nucleocytoplasmic transport|platelet-derived growth factor receptor signaling pathway|positive regulation of neurogenesis|regulation of DNA-dependent transcription in response to stress|regulation of G-protein coupled receptor protein signaling pathway|response to oxidative stress|spindle organization|visual learning|zygote asymmetric cell division	cell junction|centrosome|dendritic spine|microtubule|PML body|postsynaptic density|postsynaptic membrane|spindle pole	GDP-dissociation inhibitor activity|GTPase activator activity|microtubule binding|receptor signaling complex scaffold activity|receptor signaling protein activity			lung(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGAGTTGGGGCAGCTGCCAC	0.711													14	49					1.67942e-08	4.0569e-08	1	0
DNAH8	1769	broad.mit.edu	37	6	38820534	38820534	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr6:38820534G>A	uc003ooe.1	+	38	5480	c.4880G>A	c.(4879-4881)CGC>CAC	p.R1627H		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GACTATGATCGCATCATGGCC	0.378													8	30					0	0	0	0
EIF3B	8662	broad.mit.edu	37	7	2409186	2409186	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:2409186C>A	uc003slx.2	+	10	1566	c.1483C>A	c.(1483-1485)CTG>ATG	p.L495M	EIF3B_uc003sly.2_Missense_Mutation_p.L495M|EIF3B_uc003sma.2_Missense_Mutation_p.L223M	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	495					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CAGGGTAACCCTGATGCAGCT	0.488													6	198					0.00116845	0.00256036	1	0
IQCE	23288	broad.mit.edu	37	7	2618149	2618149	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:2618149G>T	uc003smo.3	+	8	803	c.619G>T	c.(619-621)GAT>TAT	p.D207Y	IQCE_uc010ksm.1_Missense_Mutation_p.D207Y|IQCE_uc003sml.1_Missense_Mutation_p.D207Y|IQCE_uc011jvy.1_Missense_Mutation_p.D191Y|IQCE_uc011jvz.1_Missense_Mutation_p.D142Y|IQCE_uc003smk.3_Missense_Mutation_p.D191Y|IQCE_uc003smn.3_Missense_Mutation_p.D142Y	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	207	Potential.										0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GAAAAGGCCCGATGCCAGTTG	0.587													28	77					1.42536e-11	3.61752e-11	1	0
TMEM106B	54664	broad.mit.edu	37	7	12263867	12263867	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:12263867G>A	uc011jxk.1	+	5	697	c.297G>A	c.(295-297)ATG>ATA	p.M99I	TMEM106B_uc003ssh.2_Missense_Mutation_p.M99I	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	99	Helical; (Potential).					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		TGTATGTGATGGCTTCTGTGT	0.388													50	169					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82584801	82584801	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:82584801G>A	uc003uhx.2	-	5	5757	c.5468C>T	c.(5467-5469)CCA>CTA	p.P1823L	PCLO_uc003uhv.2_Missense_Mutation_p.P1823L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1754					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGTGTCTTTGGCCTTTCCCT	0.423													43	149					0	0	0	0
ADAM22	53616	broad.mit.edu	37	7	87785302	87785302	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:87785302G>T	uc003ujn.2	+	22	1967	c.1888G>T	c.(1888-1890)GGA>TGA	p.G630*	ADAM22_uc003ujk.1_Nonsense_Mutation_p.G630*|ADAM22_uc003ujl.1_Nonsense_Mutation_p.G630*|ADAM22_uc003ujm.2_Nonsense_Mutation_p.G630*|ADAM22_uc003ujo.2_Nonsense_Mutation_p.G630*|ADAM22_uc003ujp.1_Nonsense_Mutation_p.G682*	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	630	Cys-rich.|Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TGTGCAGCAAGGAAGAACATT	0.383													19	56					5.35267e-07	1.2626e-06	1	0
CCDC132	55610	broad.mit.edu	37	7	92905483	92905483	+	Missense_Mutation	SNP	A	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:92905483A>G	uc003umo.2	+	12	936	c.808A>G	c.(808-810)ATG>GTG	p.M270V	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.M240V|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.M270V	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	270											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ACAGACAGCAATGGATCAACT	0.343													26	55					0	0	0	0
ASNS	440	broad.mit.edu	37	7	97482391	97482391	+	Missense_Mutation	SNP	T	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:97482391T>A	uc003uot.3	-	12	1963	c.1457A>T	c.(1456-1458)CAG>CTG	p.Q486L	ASNS_uc011kin.1_Missense_Mutation_p.Q403L|ASNS_uc003uou.3_Missense_Mutation_p.Q486L|ASNS_uc003uov.3_Missense_Mutation_p.Q486L|ASNS_uc011kio.1_Missense_Mutation_p.Q465L|ASNS_uc003uow.3_Missense_Mutation_p.Q465L|ASNS_uc003uox.3_Missense_Mutation_p.Q403L	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	486	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AACGTATTCCTGTAAAATCTT	0.358													7	29					0	0	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97939786	97939786	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:97939786G>A	uc003upj.2	-	9	1189	c.926C>T	c.(925-927)CCG>CTG	p.P309L		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	309					filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TTGTGAATTCGGGGCAGCCGT	0.398													11	40					0	0	0	0
PILRB	29990	broad.mit.edu	37	7	99933531	99933531	+	5'Flank	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:99933531G>T	uc003uuk.2	+						PMS2L1_uc003uuh.2_RNA|PMS2L1_uc003uui.2_RNA|PMS2L1_uc010lgv.1_RNA|PILRB_uc003uul.2_5'Flank	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta						activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTCCCTCCACGGCTCCCACAG	0.667													5	6					0.000602214	0.00133419	1	0
LAMB4	22798	broad.mit.edu	37	7	107674717	107674717	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:107674717C>G	uc010ljo.1	-	31	4838	c.4754G>C	c.(4753-4755)CGG>CCG	p.R1585P	LAMB4_uc003vey.2_Missense_Mutation_p.R1585P|LAMB4_uc010ljp.1_Missense_Mutation_p.R554P	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	1585	Potential.|Domain I.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						AGAGTTTGCCCGTCCTTGAGT	0.338													30	89					0	0	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673487	141673487	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:141673487C>T	uc003vwx.1	-	1	87	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	1	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					TTAGAGTCAACATGATGTCAC	0.448													17	51					0	0	0	0
ZNF786	136051	broad.mit.edu	37	7	148767797	148767797	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr7:148767797C>A	uc003wfh.2	-	4	2204	c.2067G>T	c.(2065-2067)GCG>GCT	p.A689A	ZNF786_uc011kuk.1_Silent_p.A652A|ZNF786_uc003wfi.2_Silent_p.A603A	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	689	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGAGCAGCTGCGCCTTCAGGC	0.557													53	141					1.39843e-22	3.86738e-22	1	0
SLCO5A1	81796	broad.mit.edu	37	8	70744880	70744880	+	Missense_Mutation	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:70744880C>A	uc003xyl.2	-	2	736	c.29G>T	c.(28-30)GGG>GTG	p.G10V	SLCO5A1_uc010lzb.2_Missense_Mutation_p.G10V|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_Missense_Mutation_p.G10V|SLCO5A1_uc010lzc.2_Missense_Mutation_p.G10V	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	10	Cytoplasmic (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CTCTCCCGCCCCGGGCTGCAG	0.617											OREG0018815	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	71					7.38237e-10	1.82736e-09	1	0
CA2	760	broad.mit.edu	37	8	86385963	86385963	+	Missense_Mutation	SNP	C	G	G			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:86385963C>G	uc003ydk.2	+	3	454	c.274C>G	c.(274-276)CAG>GAG	p.Q92E		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	92		Activator.	Q -> P (in OPTB3; in Czechoslovakia).		one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CAGATTGATTCAGTTTCACTT	0.289													14	50					0	0	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88886052	88886052	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:88886052G>T	uc003ydz.2	-	1	245	c.148C>A	c.(148-150)CGT>AGT	p.R50S		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	50										ovary(1)	1						CAGCTTACACGCAGCTCGCGA	0.502													27	71					3.28513e-13	8.44446e-13	1	0
ANGPT1	284	broad.mit.edu	37	8	108306199	108306199	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:108306199G>T	uc003ymn.2	-	6	1471	c.1003C>A	c.(1003-1005)CTA>ATA	p.L335I	ANGPT1_uc011lhv.1_Missense_Mutation_p.L135I|ANGPT1_uc003ymo.2_Missense_Mutation_p.L334I|ANGPT1_uc003ymp.3_Missense_Mutation_p.L134I	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	335	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TGGAAATCTAGACTTCCATCT	0.348													10	82					7.48243e-07	1.75465e-06	1	0
CSMD3	114788	broad.mit.edu	37	8	114326998	114326998	+	Missense_Mutation	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:114326998G>C	uc003ynu.2	-	2	362	c.203C>G	c.(202-204)ACT>AGT	p.T68S	CSMD3_uc003ynt.2_Missense_Mutation_p.T28S|CSMD3_uc011lhx.1_Missense_Mutation_p.T68S|CSMD3_uc010mcx.1_Missense_Mutation_p.T68S|CSMD3_uc003ynx.3_Missense_Mutation_p.T68S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	68	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCTTTTAAAGTTCCACCACA	0.308										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	138					0	0	0	0
ASAP1	50807	broad.mit.edu	37	8	131127924	131127924	+	Missense_Mutation	SNP	T	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:131127924T>C	uc003yta.1	-	22	2150	c.2122A>G	c.(2122-2124)AAT>GAT	p.N708D	ASAP1_uc003ysz.1_Missense_Mutation_p.N519D|ASAP1_uc011liw.1_Missense_Mutation_p.N701D	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	708					cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TGTCGAAGATTCCACTCATAT	0.413													36	298					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139160820	139160820	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:139160820C>T	uc003yuy.2	-	14	3562	c.3391G>A	c.(3391-3393)GAG>AAG	p.E1131K	FAM135B_uc003yux.2_Missense_Mutation_p.E1032K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E693K|FAM135B_uc003yvb.2_Missense_Mutation_p.R658K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1131										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTTTCTTCCTCTTCCTCTGGT	0.373										HNSCC(54;0.14)			5	23					0	0	0	0
CHRAC1	54108	broad.mit.edu	37	8	141521631	141521631	+	Silent	SNP	C	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:141521631C>A	uc003yvl.2	+	1	231	c.33C>A	c.(31-33)GGC>GGA	p.G11G	CHRAC1_uc010mem.1_RNA	NM_017444	NP_059140	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1	11					chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(1)	1	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			AAGACAAGGGCGGGGAGCAGC	0.697													6	7					0.00116845	0.00256036	1	0
RECQL4	9401	broad.mit.edu	37	8	145738093	145738093	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr8:145738093C>T	uc003zdj.2	-	17	2849	c.2817G>A	c.(2815-2817)GCG>GCA	p.A939A		NM_004260	NP_004251	O94761	RECQ4_HUMAN	RecQ protein-like 4	939					DNA duplex unwinding|DNA recombination|DNA repair	cytoplasm|nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|DNA strand annealing activity|zinc ion binding			breast(2)|lung(1)|skin(1)	4	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TATAGGTGGTCGCCAGCAGCT	0.672			N|F|S			osteosarcoma|skin basal and sqamous cell		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	RAPADILINO_syndrome|Rothmund-Thomson_syndrome|Baller-Gerold_syndrome				5	35					0	0	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971186	21971186	+	Nonsense_Mutation	SNP	G	A	A	rs121913387		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:21971186G>A	uc003zpk.2	-	2	384	c.172C>T	c.(172-174)CGA>TGA	p.R58*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P113L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	58	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R58*(68)|p.?(14)|p.M53_R58del(3)|p.R58fs*59(2)|p.M54fs*61(2)|p.R58fs*89(1)|p.R58R(1)|p.V28_V51del(1)|p.A57_R58>V*(1)|p.R58fs*61(1)|p.R58fs*62(1)|p.G55fs*86(1)|p.R58Q(1)|p.P113L(1)|p.A57fs*85(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCCGCCACTCGGGCGCTGCCC	0.677		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	8					0	0	0	0
UBAP1	51271	broad.mit.edu	37	9	34249862	34249862	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:34249862C>T	uc003ztx.2	+	5	1404	c.1169C>T	c.(1168-1170)CCC>CTC	p.P390L	UBAP1_uc010mka.1_Missense_Mutation_p.P426L|UBAP1_uc003zty.2_Missense_Mutation_p.P390L|UBAP1_uc011loi.1_Missense_Mutation_p.P426L|UBAP1_uc011loj.1_Missense_Mutation_p.P454L|KIF24_uc010mkb.2_Intron|UBAP1_uc003ztz.2_Missense_Mutation_p.P390L	NM_016525	NP_057609	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	390	UBA 1.					cytoplasm					0			LUSC - Lung squamous cell carcinoma(29;0.00272)			ATGCTGTCCCCCAGCGAGCGG	0.532													39	57					0	0	0	0
ECM2	1842	broad.mit.edu	37	9	95277012	95277012	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:95277012C>T	uc004ash.2	-	4	1020	c.955G>A	c.(955-957)GGG>AGG	p.G319R	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.G297R|ECM2_uc011lty.1_Missense_Mutation_p.G319R|ECM2_uc004asg.2_Missense_Mutation_p.G297R	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	319	LRRNT.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						AGAGAGCACCCGCTTGGCAGG	0.532													22	36					0	0	0	0
DBC1	1620	broad.mit.edu	37	9	122011377	122011377	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:122011377C>T	uc004bkc.2	-	3	726	c.270G>A	c.(268-270)CTG>CTA	p.L90L	DBC1_uc004bkd.2_Silent_p.L90L	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	90	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GATGGCGGACCAGATCTCTCC	0.532													16	26					0	0	0	0
ASMTL	8623	broad.mit.edu	37	X	1538002	1538002	+	Silent	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:1538002C>T	uc004cpx.1	-	10	1362	c.1251G>A	c.(1249-1251)GCG>GCA	p.A417A	ASMTL_uc011mhe.1_Silent_p.A341A|ASMTL_uc004cpy.1_Silent_p.A401A|ASMTL_uc011mhf.1_Silent_p.A359A	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	417	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TCTGGTAGTACGCATCCTGGA	0.667													7	40					0	0	0	0
FAM47C	442444	broad.mit.edu	37	X	37027194	37027194	+	Silent	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:37027194G>A	uc004ddl.1	+	1	725	c.711G>A	c.(709-711)GAG>GAA	p.E237E		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	237										ovary(3)	3						TCCACCTGGAGCCTCCAGAGA	0.632													37	15					0	0	0	0
DUSP21	63904	broad.mit.edu	37	X	44703891	44703891	+	Silent	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:44703891G>C	uc004dgd.2	+	1	643	c.513G>C	c.(511-513)TCG>TCC	p.S171S		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	171						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						TGATCAACTCGCCGGTAGGTA	0.512													13	35					0	0	0	0
ZXDA	7789	broad.mit.edu	37	X	57935809	57935809	+	Missense_Mutation	SNP	G	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:57935809G>A	uc004dve.2	-	1	1259	c.1046C>T	c.(1045-1047)GCG>GTG	p.A349V		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	349	C2H2-type 3.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CTTCATGTGCGCCTTGAGGTT	0.617													16	23					0	0	0	0
AR	367	broad.mit.edu	37	X	66765158	66765158	+	Missense_Mutation	SNP	T	A	A	rs78686797		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:66765158T>A	uc004dwu.1	+	1	1285	c.170T>A	c.(169-171)CTG>CAG	p.L57Q	AR_uc011mpd.1_Missense_Mutation_p.L57Q|AR_uc011mpe.1_RNA|AR_uc011mpf.1_Missense_Mutation_p.L57Q	NM_000044	NP_000035	P10275	ANDR_HUMAN	androgen receptor isoform 1	57	Poly-Leu.|Modulating.		L -> Q (in prostate cancer).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(3)|lung(2)|breast(2)|central_nervous_system(1)	8	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	TTGCTGCTGCTgcagcagcag	0.338									Androgen_Insensitivity_Syndrome				5	19					0	0	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962796	73962796	+	Silent	SNP	G	C	C			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:73962796G>C	uc004eby.2	-	3	2213	c.1596C>G	c.(1594-1596)ACC>ACG	p.T532T		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	532					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GCTCCTTACGGGTTACTTTTC	0.418													17	9					0	0	0	0
MAGT1	84061	broad.mit.edu	37	X	77112989	77112989	+	Missense_Mutation	SNP	G	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:77112989G>T	uc004fof.2	-	4	554	c.492C>A	c.(490-492)AAC>AAA	p.N164K	MAGT1_uc004fog.3_RNA	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	132					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						CTGAATTCATGTTTAGCTGAA	0.338													10	82					0.00185496	0.00402075	1	0
BEX5	340542	broad.mit.edu	37	X	101408934	101408934	+	Missense_Mutation	SNP	C	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:101408934C>T	uc010nnz.2	-	3	606	c.304G>A	c.(304-306)GAT>AAT	p.D102N	BEX5_uc004eir.2_Missense_Mutation_p.D102N	NM_001159560	NP_001153032	Q5H9J7	BEX5_HUMAN	brain expressed, X-linked 5	102						cytoplasm				upper_aerodigestive_tract(1)	1						TCATGATGATCATGGTGAGGA	0.418													36	25					0	0	0	0
Unknown	0	broad.mit.edu	37	10	27620447	27620448	+	IGR	INS	-	TT	TT	rs142562667	by1000genomes	TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr10:27620447_27620448insTT								LOC387646 (79212 upstream) : PTCHD3 (66669 downstream)																							ACTCAGGCTTCTTTCCGCCAAG	0.465													---	---	---							
IRF9	10379	broad.mit.edu	37	14	24631429	24631450	+	Frame_Shift_Del	DEL	CCCGGAGTGTGCTGGGATGATA	-	-	rs145197850	byFrequency	TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr14:24631429_24631450delCCCGGAGTGTGCTGGGATGATA	uc001wmq.2	+	2	203_224	c.76_97delCCCGGAGTGTGCTGGGATGATA	c.(76-99)CCCGGAGTGTGCTGGGATGATACAfs	p.P26fs	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_5'Flank	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	26_33	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		TGGGCAGTTTCCCGGAGTGTGCTGGGATGATACAGCTAAGAC	0.572													---	---	---							
Unknown	0	broad.mit.edu	37	16	33939019	33939019	+	IGR	DEL	C	-	-	rs113683091		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr16:33939019delC								None (None upstream) : MIR1826 (26489 downstream)																							GTTGCACAGGCCGCCTGCGTG	0.667													---	---	---							
C17orf53	78995	broad.mit.edu	37	17	42230139	42230145	+	Frame_Shift_Del	DEL	GCGCAAG	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:42230139_42230145delGCGCAAG	uc002ifi.1	+	5	1628_1634	c.1443_1449delGCGCAAG	c.(1441-1449)CTGCGCAAGfs	p.L481fs	C17orf53_uc010czq.1_Frame_Shift_Del_p.L481fs|C17orf53_uc002ifj.1_Intron|C17orf53_uc002ifk.1_Intron	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	481_483											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TCATGGTGCTGCGCAAGGTAAGGATTC	0.541													---	---	---							
CACNA1G	8913	broad.mit.edu	37	17	48653249	48653251	+	In_Frame_Del	DEL	CAC	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr17:48653249_48653251delCAC	uc002irk.1	+	8	1858_1860	c.1486_1488delCAC	c.(1486-1488)CACdel	p.H504del	CACNA1G_uc002iri.1_In_Frame_Del_p.H504del|CACNA1G_uc002irj.1_In_Frame_Del_p.H504del|CACNA1G_uc002irl.1_In_Frame_Del_p.H504del|CACNA1G_uc002irm.1_In_Frame_Del_p.H504del|CACNA1G_uc002irn.1_In_Frame_Del_p.H504del|CACNA1G_uc002iro.1_In_Frame_Del_p.H504del|CACNA1G_uc002irp.1_In_Frame_Del_p.H504del|CACNA1G_uc002irq.1_In_Frame_Del_p.H504del|CACNA1G_uc002irr.1_In_Frame_Del_p.H504del|CACNA1G_uc002irs.1_In_Frame_Del_p.H504del|CACNA1G_uc002irt.1_In_Frame_Del_p.H504del|CACNA1G_uc002irv.1_In_Frame_Del_p.H504del|CACNA1G_uc002irw.1_In_Frame_Del_p.H504del|CACNA1G_uc002iru.1_In_Frame_Del_p.H504del|CACNA1G_uc002irx.1_In_Frame_Del_p.H417del|CACNA1G_uc002iry.1_In_Frame_Del_p.H417del|CACNA1G_uc002irz.1_In_Frame_Del_p.H417del|CACNA1G_uc002isa.1_In_Frame_Del_p.H417del|CACNA1G_uc002isb.1_In_Frame_Del_p.H417del|CACNA1G_uc002isc.1_In_Frame_Del_p.H417del|CACNA1G_uc002isd.1_In_Frame_Del_p.H417del|CACNA1G_uc002ise.1_In_Frame_Del_p.H417del|CACNA1G_uc002isf.1_In_Frame_Del_p.H417del|CACNA1G_uc002isg.1_In_Frame_Del_p.H417del|CACNA1G_uc002ish.1_In_Frame_Del_p.H417del|CACNA1G_uc002isi.1_In_Frame_Del_p.H417del	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	504	Cytoplasmic (Potential).|Poly-His.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCACCTGGTGcaccaccaccacc	0.596													---	---	---							
DAPK3	1613	broad.mit.edu	37	19	3964890	3964890	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr19:3964890delA	uc002lzc.1	-	2	255	c.162delT	c.(160-162)CGTfs	p.R54fs	DAPK3_uc002lzd.1_Frame_Shift_Del_p.R54fs	NM_001348	NP_001339	O43293	DAPK3_HUMAN	death-associated protein kinase 3	54	Protein kinase.				apoptosis|chromatin modification|induction of apoptosis|intracellular protein kinase cascade	cytoplasm|PML body	ATP binding|leucine zipper domain binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|ovary(1)|large_intestine(1)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTCACCCCACGCCGGCTGG	0.632													---	---	---							
Unknown	0	broad.mit.edu	37	22	20151841	20151842	+	IGR	INS	-	CAC	CAC	rs10627070		TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr22:20151841_20151842insCAC								ZDHHC8 (16312 upstream) : LOC150197 (42013 downstream)																							accaccaccatcaccaccacca	0.025													---	---	---							
NSUN7	79730	broad.mit.edu	37	4	40752855	40752856	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:40752855_40752856insT	uc003gvj.3	+	2	640_641	c.145_146insT	c.(145-147)ATGfs	p.M49fs	NSUN7_uc003gvh.2_Frame_Shift_Ins_p.M49fs|NSUN7_uc003gvi.3_Frame_Shift_Ins_p.M49fs	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CGTTTATGTCATGGCAGCCAAC	0.515													---	---	---							
FRYL	285527	broad.mit.edu	37	4	48550722	48550724	+	In_Frame_Del	DEL	GAA	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr4:48550722_48550724delGAA	uc003gyh.1	-	40	5476_5478	c.4871_4873delTTC	c.(4870-4875)CTTCAT>CAT	p.L1624del	FRYL_uc003gyg.1_In_Frame_Del_p.L320del|FRYL_uc003gyi.1_In_Frame_Del_p.L513del|FRYL_uc003gyj.1_5'Flank	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	1624					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AAAATTGCATGAAGAAGAAGATG	0.310													---	---	---							
THBS2	7058	broad.mit.edu	37	6	169648982	169648983	+	Frame_Shift_Del	DEL	CG	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr6:169648982_169648983delCG	uc003qwt.2	-	4	386_387	c.138_139delCG	c.(136-141)CGCGGGfs	p.R46fs		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	46_47	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GGGTCGGGCCCGCGGAACTGCT	0.584													---	---	---							
PSIP1	11168	broad.mit.edu	37	9	15478476	15478485	+	Frame_Shift_Del	DEL	TGTCACTCTC	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chr9:15478476_15478485delTGTCACTCTC	uc003zlv.3	-	8	949_958	c.619_628delGAGAGTGACA	c.(619-630)GAGAGTGACATCfs	p.E207fs	PSIP1_uc003zlw.3_Frame_Shift_Del_p.E207fs|PSIP1_uc003zlz.3_Frame_Shift_Del_p.E207fs|PSIP1_uc003zma.3_Frame_Shift_Del_p.E198fs|PSIP1_uc003zly.2_Frame_Shift_Del_p.E207fs	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	207_210					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TAAACTCACATGTCACTCTCTGAAGGACAG	0.338													---	---	---							
NYX	60506	broad.mit.edu	37	X	41333914	41333915	+	Frame_Shift_Ins	INS	-	A	A			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:41333914_41333915insA	uc004dfh.2	+	2	1638_1639	c.1208_1209insA	c.(1207-1209)CCAfs	p.P403fs	NYX_uc011mku.1_Frame_Shift_Ins_p.P398fs	NM_022567	NP_072089	Q9GZU5	NYX_HUMAN	nyctalopin precursor	403					response to stimulus|visual perception	intracellular|proteinaceous extracellular matrix				lung(2)	2						GGCCCGTCCCCAGAACCAGCGG	0.698													---	---	---							
Unknown	0	broad.mit.edu	37	X	42384560	42384560	+	IGR	DEL	A	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:42384560delA								CASK (602273 upstream) : PPP1R2P9 (252059 downstream)																							CAGCCAAGGGAAAAAAAAAAA	0.219													---	---	---							
Unknown	0	broad.mit.edu	37	X	48305869	48305869	+	IGR	DEL	T	-	-			TCGA-CV-6945-01A-11D-1912-08	TCGA-CV-6945-10A-01D-1912-08									Somatic	Phase_I	Capture				Illumina GAIIx	fcfc9b74-5b8a-45b7-97ca-4e477e941e7c	0e82fe21-343e-4c8a-8b59-f1fd2261bebd	g.chrX:48305869delT								SSX4 (53084 upstream) : SLC38A5 (11059 downstream)																							ATAATACCCATTTTTTTTCTG	0.353													---	---	---							
