Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
PLEKHN1	84069	broad.mit.edu	37	1	906212	906212	+	Silent	SNP	G	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:906212G>T	uc001ace.2	+	5	593	c.558G>T	c.(556-558)CTG>CTT	p.L186L	PLEKHN1_uc001acd.2_Intron|PLEKHN1_uc001acf.2_Intron	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	186	PH 1.										0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCCTGTGGCTGCGGAGCACGT	0.692000													13	23					9.31168e-06	1.02233e-05	1	0
CHD5	26038	broad.mit.edu	37	1	6209356	6209356	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:6209356C>G	uc001amb.1	-	8	1211	c.1111G>C	c.(1111-1113)GAC>CAC	p.D371H	CHD5_uc001amc.1_5'Flank	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	371	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGCTCTGGGTCCAGGCATACG	0.657000													3	21					0	0	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724545	7724545	+	Silent	SNP	G	C	C	rs142993717		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:7724545G>C	uc001aoi.2	+	9	2145	c.1938G>C	c.(1936-1938)ACG>ACC	p.T646T		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TGATGCCCACGGTGAAAACGG	0.637000													54	167					0	0	0	0
KIF1B	23095	broad.mit.edu	37	1	10318626	10318626	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:10318626G>C	uc001aqx.3	+	4	461	c.259G>C	c.(259-261)GAG>CAG	p.E87Q	KIF1B_uc001aqv.3_Missense_Mutation_p.E87Q|KIF1B_uc001aqw.3_Missense_Mutation_p.E87Q|KIF1B_uc001aqy.2_Missense_Mutation_p.E87Q|KIF1B_uc001aqz.2_Missense_Mutation_p.E87Q|KIF1B_uc001ara.2_Missense_Mutation_p.E87Q|KIF1B_uc001arb.2_Missense_Mutation_p.E87Q|KIF1B_uc009vmt.2_RNA	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	87	Kinesin-motor.			E -> G (in Ref. 7; BAA25517).	anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ACACGCCTTTGAGGGATATAA	0.418000													21	47					0	0	0	0
VPS13D	55187	broad.mit.edu	37	1	12443180	12443180	+	Missense_Mutation	SNP	G	C	C	rs140461198		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:12443180G>C	uc001atv.2	+	58	11477	c.11336G>C	c.(11335-11337)AGA>ACA	p.R3779T	VPS13D_uc001atw.2_Missense_Mutation_p.R3754T|VPS13D_uc001atx.2_Missense_Mutation_p.R2966T|VPS13D_uc009vnl.2_RNA	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	3778					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTATCCATCAGAGTCATCCCA	0.433000													9	45					0	0	0	0
HTR6	3362	broad.mit.edu	37	1	19992252	19992252	+	Silent	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:19992252C>A	uc001bcl.2	+	1	473	c.6C>A	c.(4-6)GTC>GTA	p.V2V		NM_000871	NP_000862	P50406	5HT6R_HUMAN	5-hydroxytryptamine (serotonin) receptor 6	2	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	histamine receptor activity|protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.81e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00117)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)	Granisetron(DB00889)|Ondansetron(DB00904)|Sertindole(DB06144)	TCCTCATGGTCCCAGAGCCGG	0.468000													4	13					0.00024832	0.000261653	1	0
C1orf201	90529	broad.mit.edu	37	1	24706250	24706250	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:24706250C>G	uc001bjc.2	-	5	490	c.355G>C	c.(355-357)GAT>CAT	p.D119H	C1orf201_uc001bja.2_Missense_Mutation_p.D72H|C1orf201_uc001bjb.2_Missense_Mutation_p.D27H|C1orf201_uc001bjd.2_Missense_Mutation_p.D119H|C1orf201_uc001bje.1_Missense_Mutation_p.D72H|C1orf201_uc001bjf.2_5'UTR			Q5TH74	CA201_HUMAN	RecName: Full=UPF0490 protein C1orf201;	119										ovary(1)|breast(1)	2		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0191)|all_lung(284;0.0251)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.056)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.48e-25)|Colorectal(126;7.29e-08)|COAD - Colon adenocarcinoma(152;3.85e-06)|GBM - Glioblastoma multiforme(114;0.000399)|BRCA - Breast invasive adenocarcinoma(304;0.00107)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00393)|READ - Rectum adenocarcinoma(331;0.0672)|Lung(427;0.145)		GAAATAAAATCCGATGGGATA	0.428000													6	35					0	0	0	0
GRIK3	2899	broad.mit.edu	37	1	37291332	37291332	+	Silent	SNP	G	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:37291332G>T	uc001caz.2	-	11	1761	c.1626C>A	c.(1624-1626)ATC>ATA	p.I542I	GRIK3_uc001cba.1_Silent_p.I542I	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	542	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TTCGATACAGGATGCTCACAC	0.572000													22	34					1.28384e-07	1.45009e-07	1	0
MTF1	4520	broad.mit.edu	37	1	38280845	38280845	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:38280845T>C	uc001cce.1	-	11	2366	c.2225A>G	c.(2224-2226)GAG>GGG	p.E742G		NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	742						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CATCTCCTCCTCCCCCTGCAG	0.547000													7	77					0	0	0	0
KIAA0494	9813	broad.mit.edu	37	1	47183657	47183657	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:47183657C>G	uc001cqk.3	-	1	1080	c.103G>C	c.(103-105)GAG>CAG	p.E35Q	KIAA0494_uc010omh.1_Missense_Mutation_p.E35Q|KIAA0494_uc001cql.1_Missense_Mutation_p.E35Q	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	35							calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TCGGGAGGCTCAGTGCGAAGC	0.542000													20	49					0	0	0	0
GBP7	388646	broad.mit.edu	37	1	89616257	89616257	+	Silent	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:89616257G>A	uc001dna.2	-	6	766	c.627C>T	c.(625-627)GGC>GGT	p.G209G	GBP2_uc001dmy.1_RNA	NM_207398	NP_997281	Q8N8V2	GBP7_HUMAN	guanylate binding protein 4-like	209						integral to membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GGGGATTCTTGCCTGCAGAAT	0.403000													11	67					0	0	0	0
CELSR2	1952	broad.mit.edu	37	1	109810498	109810498	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:109810498C>G	uc001dxa.3	+	17	6195	c.6134C>G	c.(6133-6135)TCA>TGA	p.S2045*		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2045	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CGGAATGAGTCAGGCCTAGAC	0.632000													3	31					0	0	0	0
SORT1	6272	broad.mit.edu	37	1	109897086	109897086	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:109897086G>A	uc001dxm.1	-	5	660	c.611C>T	c.(610-612)GCG>GTG	p.A204V	SORT1_uc010ovi.1_Missense_Mutation_p.A68V|SORT1_uc009wfb.2_Missense_Mutation_p.A68V	NM_002959	NP_002950	Q99523	SORT_HUMAN	sortilin 1 preproprotein	204	Extracellular (Potential).|BNR 2.				endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			ovary(1)	1		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		AAAATTCTTCGCAAAATCTGA	0.418000													30	77					0	0	0	0
ATP8B2	57198	broad.mit.edu	37	1	154306629	154306629	+	Silent	SNP	C	T	T	rs142408071	by1000genomes	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:154306629C>T	uc001fey.1	+	9	882	c.693C>T	c.(691-693)AGC>AGT	p.S231S	ATP8B2_uc001few.2_Silent_p.S212S|ATP8B2_uc001fex.2_Silent_p.S245S	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	231	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ACAAATTCAGCGGAACCCTCT	0.517000													104	167					0	0	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204413526	204413526	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:204413526A>T	uc001haw.2	-	18	3184	c.2705T>A	c.(2704-2706)ATG>AAG	p.M902K	PIK3C2B_uc010pqv.1_Missense_Mutation_p.M874K	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	902					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CTGCACAGCCATACGACGCAC	0.587000													4	15					0	0	0	0
NLRP3	114548	broad.mit.edu	37	1	247587937	247587937	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:247587937C>G	uc001icr.2	+	5	1330	c.1192C>G	c.(1192-1194)CTG>GTG	p.L398V	NLRP3_uc001ics.2_Missense_Mutation_p.L398V|NLRP3_uc001icu.2_Missense_Mutation_p.L398V|NLRP3_uc001icw.2_Missense_Mutation_p.L398V|NLRP3_uc001icv.2_Missense_Mutation_p.L398V|NLRP3_uc010pyw.1_Missense_Mutation_p.L396V|NLRP3_uc001ict.1_Missense_Mutation_p.L396V	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	398	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGCCTTCAGTCTGATTCAGGA	0.537000													23	42					0	0	0	0
CUBN	8029	broad.mit.edu	37	10	16873286	16873286	+	Missense_Mutation	SNP	C	T	T	rs143300012	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:16873286C>T	uc001ioo.2	-	65	10545	c.10493G>A	c.(10492-10494)CGT>CAT	p.R3498H		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3498	CUB 26.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TTCATATCCACGATCAGAAGT	0.393000													20	24					0	0	0	0
ARMC4	55130	broad.mit.edu	37	10	28272787	28272787	+	Silent	SNP	T	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:28272787T>A	uc009xky.2	-	6	902	c.804A>T	c.(802-804)GGA>GGT	p.G268G	ARMC4_uc010qds.1_5'Flank|ARMC4_uc010qdt.1_5'Flank|ARMC4_uc001itz.2_Silent_p.G268G|ARMC4_uc010qdu.1_5'Flank	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	268							binding			ovary(4)|skin(2)	6						TTAAAAATACTCCTCCTGCAC	0.433000													12	26					0	0	0	0
OR13A1	79290	broad.mit.edu	37	10	45799323	45799323	+	Missense_Mutation	SNP	C	G	G	rs116633831	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:45799323C>G	uc001jcc.1	-	4	857	c.548G>C	c.(547-549)CGC>CCC	p.R183P	OR13A1_uc001jcd.1_Missense_Mutation_p.R179P	NM_001004297	NP_001004297	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A,	183	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GAAATCCAAGCGCAGCATCAG	0.592000													20	48					0	0	0	0
MYPN	84665	broad.mit.edu	37	10	69881386	69881386	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:69881386C>T	uc001jnm.3	+	3	376	c.191C>T	c.(190-192)TCA>TTA	p.S64L	MYPN_uc001jnl.1_Missense_Mutation_p.S64L|MYPN_uc001jnn.3_Intron|MYPN_uc001jno.3_Missense_Mutation_p.S64L|MYPN_uc001jnp.1_Missense_Mutation_p.S64L|MYPN_uc009xps.2_Missense_Mutation_p.S64L|MYPN_uc009xpt.2_Missense_Mutation_p.S64L|MYPN_uc010qit.1_5'UTR|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	64	Interaction with CARP.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CCAGATCTTTCAGCCTTTCTG	0.527000													19	53					0	0	0	0
CALHM2	51063	broad.mit.edu	37	10	105207026	105207026	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr10:105207026G>C	uc001kwz.2	-	3	1241	c.855C>G	c.(853-855)TAC>TAG	p.Y285*	CALHM2_uc001kxa.2_Nonsense_Mutation_p.Y285*|CALHM2_uc001kxc.2_3'UTR|CALHM2_uc001kxb.2_Nonsense_Mutation_p.Y285*	NM_015916	NP_057000	Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	285						integral to membrane				skin(1)	1						CACGGTACAAGTAGACGCCGG	0.617000													19	43					0	0	0	0
FXC1	26515	broad.mit.edu	37	11	6503307	6503307	+	Silent	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:6503307G>C	uc001mdn.3	+	3	238	c.168G>C	c.(166-168)CTG>CTC	p.L56L	ARFIP2_uc001mdk.2_5'Flank|ARFIP2_uc001mdl.2_5'Flank|ARFIP2_uc010ral.1_5'Flank|ARFIP2_uc010ram.1_5'Flank|ARFIP2_uc010ran.1_5'Flank|ARFIP2_uc001mdm.2_5'Flank|ARFIP2_uc009yfe.1_5'Flank|FXC1_uc001mdo.3_RNA	NM_012192	NP_036324	Q9Y5J6	TIM9B_HUMAN	mitochondrial import inner membrane translocase	56					cell-matrix adhesion|protein import into mitochondrial inner membrane|transmembrane transport	mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex	metal ion binding				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;3.26e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTGGGAAGCTGATCCATTCCA	0.602000													21	58					0	0	0	0
FIBIN	387758	broad.mit.edu	37	11	27016191	27016191	+	Missense_Mutation	SNP	G	C	C	rs144159497		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:27016191G>C	uc001mrd.2	+	1	564	c.118G>C	c.(118-120)GAT>CAT	p.D40H		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	40						extracellular region|Golgi apparatus					0						CTTCGTGCCCGATGGGGACTA	0.592000													18	17					0	0	0	0
PDHX	8050	broad.mit.edu	37	11	34978997	34978997	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:34978997G>C	uc001mvt.2	+	4	935	c.409G>C	c.(409-411)GAT>CAT	p.D137H	PDHX_uc010rep.1_Missense_Mutation_p.D122H|PDHX_uc010req.1_Intron	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	137					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			AGAAGGAGAAGATTGGAAACA	0.403000													20	55					0	0	0	0
RAG1	5896	broad.mit.edu	37	11	36595094	36595094	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:36595094G>C	uc001mwu.3	+	2	364	c.240G>C	c.(238-240)TTG>TTC	p.L80F	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	80	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				CTCAGCCATTGTTAAAAGCCC	0.488000									Familial_Hemophagocytic_Lymphohistiocytosis				17	108					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62291028	62291028	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62291028C>T	uc001ntl.2	-	5	11161	c.10861G>A	c.(10861-10863)GAA>AAA	p.E3621K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3621					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				ACATCGACTTCAGGGCCTTCT	0.483000													78	81					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62291184	62291184	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62291184C>T	uc001ntl.2	-	5	11005	c.10705G>A	c.(10705-10707)GAA>AAA	p.E3569K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3569					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AGATCCCCTTCAAGTTTGGGA	0.458000													83	55					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62292529	62292529	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62292529C>T	uc001ntl.2	-	5	9660	c.9360G>A	c.(9358-9360)ATG>ATA	p.M3120I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3120					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CAGGAACTTTCATGTCACCTT	0.468000													92	99					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62292958	62292958	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62292958C>T	uc001ntl.2	-	5	9231	c.8931G>A	c.(8929-8931)GTG>GTA	p.V2977V	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2977					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CATCGCCCTTCACCTTGGGAC	0.507000													66	67					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62294979	62294979	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62294979C>G	uc001ntl.2	-	5	7210	c.6910G>C	c.(6910-6912)GAG>CAG	p.E2304Q	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2304					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AAGTGCATCTCAGGCATCTTA	0.478000													80	87					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62295736	62295736	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62295736C>A	uc001ntl.2	-	5	6453	c.6153G>T	c.(6151-6153)ATG>ATT	p.M2051I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2051					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGCATTTTCATCTTGGGCA	0.512000													137	127					7.45053e-56	8.66469e-56	1	0
AHNAK	79026	broad.mit.edu	37	11	62296638	62296638	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62296638C>T	uc001ntl.2	-	5	5551	c.5251G>A	c.(5251-5253)GAT>AAT	p.D1751N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1751					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAGGAGCATCAGTGTCCACA	0.483000													76	62					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92523229	92523229	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:92523229G>C	uc001pdj.3	+	7	4473	c.4456G>C	c.(4456-4458)GAT>CAT	p.D1486H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1486	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAAGCCACAGATAGAGATGA	0.468000										TCGA Ovarian(4;0.039)			41	44					0	0	0	0
SLC6A13	6540	broad.mit.edu	37	12	332337	332337	+	Missense_Mutation	SNP	C	A	A	rs145396701	by1000genomes	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:332337C>A	uc001qic.1	-	12	1428	c.1375G>T	c.(1375-1377)GTG>TTG	p.V459L	SLC6A13_uc009zdj.1_Missense_Mutation_p.V449L|SLC6A13_uc010sdl.1_Missense_Mutation_p.V367L	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	459	Helical; Name=10; (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			AAGATGGCCACGAACAGGAGG	0.522000													7	22					7.48243e-07	8.27283e-07	1	0
NINJ2	4815	broad.mit.edu	37	12	675268	675268	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:675268A>G	uc001qil.2	-	2	339	c.248T>C	c.(247-249)ATG>ACG	p.M83T	NINJ2_uc010sdr.1_Missense_Mutation_p.M1T|NINJ2_uc010sds.1_Missense_Mutation_p.M83T	NM_016533	NP_057617	Q9NZG7	NINJ2_HUMAN	ninjurin 2	37	Extracellular (Potential).				nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				ovary(2)	2	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			CACGTCCAGCATGCTCTCCGC	0.602000													11	34					0	0	0	0
LALBA	3906	broad.mit.edu	37	12	48962875	48962875	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:48962875G>C	uc001rrt.2	-	2	308	c.282C>G	c.(280-282)ATC>ATG	p.I94M		NM_002289	NP_002280	P00709	LALBA_HUMAN	lactalbumin, alpha- precursor	94					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity				0						TGTCACAGGAGATGTCACAGA	0.468000													19	76					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49443703	49443703	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:49443703G>C	uc001rta.3	-	11	3668	c.3668C>G	c.(3667-3669)TCA>TGA	p.S1223*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1223					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GAGGGGCTCTGAGCCAGGAAA	0.612000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			29	42					0	0	0	0
OAS2	4939	broad.mit.edu	37	12	113442855	113442855	+	Silent	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:113442855C>A	uc001tuj.2	+	7	1436	c.1296C>A	c.(1294-1296)GTC>GTA	p.V432V	OAS2_uc001tui.1_Silent_p.V432V	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	432	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						ACAAAATCGTCAAGGAAATCC	0.507000													4	27					0.00024832	0.000261653	1	0
BRCA2	675	broad.mit.edu	37	13	32903578	32903578	+	Splice_Site	SNP	A	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:32903578A>C	uc001uub.1	+	8	859	c.632_splice	c.e8-2	p.V211_splice	BRCA2_uc001uua.1_Splice_Site_p.V88_splice	NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset						cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding	p.?(1)		ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		TTTATCTTACAGTCAGAAATG	0.284000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			5	2					0	0	0	0
C13orf23	80209	broad.mit.edu	37	13	39587551	39587551	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:39587551C>A	uc001uwy.2	-	11	2711	c.1838G>T	c.(1837-1839)AGT>ATT	p.S613I	C13orf23_uc001uwz.2_Missense_Mutation_p.S591I	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	613	Ser-rich.									ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GGGAGTAGGACTTGTGGGCTC	0.502000													37	50					1.30998e-17	1.51226e-17	1	0
PCDH8	5100	broad.mit.edu	37	13	53419750	53419750	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:53419750C>T	uc001vhi.2	-	2	2852	c.2649G>A	c.(2647-2649)CCG>CCA	p.P883P	PCDH8_uc001vhj.2_Silent_p.P786P	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	883	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TTCCAAAACCCGGGGAGGCAC	0.557000													4	32					0	0	0	0
GPC5	2262	broad.mit.edu	37	13	92051386	92051386	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:92051386C>T	uc010tif.1	+	1	452	c.86C>T	c.(85-87)ACC>ATC	p.T29I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	29						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GGCGTGCAGACCTGCGAAGAA	0.672000													14	5					0	0	0	0
ADAM6	8755	broad.mit.edu	37	14	106780691	106780691	+	RNA	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr14:106780691C>T	uc010tyt.1	-	413		c.15171G>A								Parts of antibodies, mostly variable regions.												0						TGGGGGCTGCCGGATCCAGCC	0.577000													45	24					0	0	0	0
SPG11	80208	broad.mit.edu	37	15	44862786	44862786	+	Silent	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:44862786G>A	uc001ztx.2	-	34	6445	c.6414C>T	c.(6412-6414)GTC>GTT	p.V2138V	SPG11_uc010bdw.2_Silent_p.V268V|SPG11_uc010ueh.1_Silent_p.V2025V|SPG11_uc010uei.1_Silent_p.V2138V	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	2138	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CGGCCTGTAGGACTCGGATGA	0.592000													4	20					0	0	0	0
SEMA6D	80031	broad.mit.edu	37	15	48060877	48060877	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:48060877G>A	uc010bek.2	+	18	2225	c.1865G>A	c.(1864-1866)CGG>CAG	p.R622Q	SEMA6D_uc001zvw.2_Intron|SEMA6D_uc001zvy.2_Missense_Mutation_p.R622Q|SEMA6D_uc001zvz.2_Intron|SEMA6D_uc001zwa.2_Intron|SEMA6D_uc001zwb.2_Intron|SEMA6D_uc001zwc.2_Intron	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	622	Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		ACAAGCTCTCGGAAATTTGTA	0.428000													13	60					0	0	0	0
TEX9	374618	broad.mit.edu	37	15	56719843	56719843	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:56719843A>T	uc002adp.2	+	11	1009	c.1004A>T	c.(1003-1005)AAA>ATA	p.K335I	TEX9_uc010ugl.1_Missense_Mutation_p.K260I	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	335	Potential.										0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		GAAGTGTTAAAATCAGAAAAC	0.279000													10	42					0	0	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58306120	58306120	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:58306120G>C	uc002aex.2	-	3	357	c.299C>G	c.(298-300)TCA>TGA	p.S100*	ALDH1A2_uc002aey.2_Nonsense_Mutation_p.S100*|ALDH1A2_uc010ugv.1_Nonsense_Mutation_p.S79*|ALDH1A2_uc010ugw.1_Nonsense_Mutation_p.S71*|ALDH1A2_uc002aew.2_Nonsense_Mutation_p.S4*	NM_003888	NP_003879	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1A2 isoform 1	100					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TCCCCTTTCTGAAGCATCCAT	0.488000													47	149					0	0	0	0
CSNK1G1	53944	broad.mit.edu	37	15	64495283	64495283	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:64495283G>C	uc002anf.2	-	10	1585	c.1105C>G	c.(1105-1107)CAG>GAG	p.Q369E	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Missense_Mutation_p.Q369E|CSNK1G1_uc002anh.1_Missense_Mutation_p.Q369E|CSNK1G1_uc002anj.2_Missense_Mutation_p.Q351E	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	369					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						ACACATACCTGATTTCGAAGA	0.443000													6	10					0	0	0	0
AEN	64782	broad.mit.edu	37	15	89169569	89169569	+	Silent	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:89169569G>A	uc002bmt.2	+	2	280	c.129G>A	c.(127-129)CGG>CGA	p.R43R	AEN_uc010bnl.2_Silent_p.R43R|AEN_uc010bnm.1_Silent_p.R43R	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	43					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						TCATGGCCCGGAAGGCCTTGC	0.627000													22	5					0	0	0	0
SEMA4B	10509	broad.mit.edu	37	15	90771754	90771754	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr15:90771754G>C	uc002boy.2	+	15	2676	c.2393G>C	c.(2392-2394)CGA>CCA	p.R798P	SEMA4B_uc002boz.2_Missense_Mutation_p.R798P|SEMA4B_uc010uqd.1_Missense_Mutation_p.R636P|SEMA4B_uc002bpa.2_Missense_Mutation_p.R636P|SEMA4B_uc010bnv.1_Intron	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			CCGGGGTCCCGAGTCTTCACT	0.677000													10	12					0	0	0	0
ABCA3	21	broad.mit.edu	37	16	2333284	2333284	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:2333284G>C	uc002cpy.1	-	26	4650	c.3938C>G	c.(3937-3939)TCA>TGA	p.S1313*	ABCA3_uc010bsk.1_Nonsense_Mutation_p.S1255*	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1313	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GGCGCACCCTGAGGCGGCCAT	0.647000													12	27					0	0	0	0
ACSM1	116285	broad.mit.edu	37	16	20673130	20673130	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:20673130C>T	uc002dhm.1	-	6	1046	c.978G>A	c.(976-978)CAG>CAA	p.Q326Q	ACSM1_uc002dhn.1_RNA|ACSM1_uc010bwg.1_Silent_p.Q326Q	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	326					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						TGAAATCCTGCTGCAGAATCA	0.368000													18	26					0	0	0	0
ITGAX	3687	broad.mit.edu	37	16	31374532	31374532	+	Missense_Mutation	SNP	A	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:31374532A>T	uc002ebu.1	+	14	1614	c.1547A>T	c.(1546-1548)CAC>CTC	p.H516L	ITGAX_uc002ebt.2_Missense_Mutation_p.H516L|ITGAX_uc010vfk.1_Missense_Mutation_p.H166L	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	516	Extracellular (Potential).|FG-GAP 6.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GAGCAGGGCCACCCCTGGGGT	0.632000													19	80					0	0	0	0
ZNF319	57567	broad.mit.edu	37	16	58031375	58031375	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:58031375C>A	uc002emx.1	-	2	1418	c.795G>T	c.(793-795)AAG>AAT	p.K265N		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	265	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCTTGAAGGTCTTCTCGCAGA	0.612000													9	37					3.09899e-07	3.45064e-07	1	0
HYDIN	54768	broad.mit.edu	37	16	70843707	70843707	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:70843707C>G	uc002ezr.2	-	85	14987	c.14859G>C	c.(14857-14859)CAG>CAC	p.Q4953H	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4954										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				ATTCTGTCCTCTGCCGTGTGT	0.517000													58	94					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577124	7577124	+	Missense_Mutation	SNP	C	T	T	rs121912657		TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:7577124C>T	uc002gim.2	-	8	1008	c.814G>A	c.(814-816)GTG>ATG	p.V272M	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.V272M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.V140M|TP53_uc010cng.1_Missense_Mutation_p.V140M|TP53_uc002gii.1_Missense_Mutation_p.V140M|TP53_uc010cnh.1_Missense_Mutation_p.V272M|TP53_uc010cni.1_Missense_Mutation_p.V272M|TP53_uc002gij.2_Missense_Mutation_p.V272M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	272	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		V -> M (in sporadic cancers; somatic mutation).|V -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> A (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V272M(67)|p.V272L(24)|p.V272E(8)|p.0?(7)|p.V272A(7)|p.V272G(4)|p.V272fs*73(4)|p.V272V(3)|p.?(2)|p.F270fs*72(1)|p.E271fs*73(1)|p.V272fs*34(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.G266_E271delGRNSFE(1)|p.V272fs*74(1)|p.F270_D281del12(1)|p.E271_R273delEVR(1)|p.V272_K292del21(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAAACACGCACCTCAAAGCTG	0.527000		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	8					0	0	0	0
ALOXE3	59344	broad.mit.edu	37	17	8017844	8017844	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:8017844G>C	uc010cnr.2	-	6	1008	c.638C>G	c.(637-639)TCA>TGA	p.S213*	ALOXE3_uc002gka.2_Nonsense_Mutation_p.S369*|ALOXE3_uc010vuo.1_Nonsense_Mutation_p.S345*|ALOXE3_uc010vup.1_RNA	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	213	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						CTTGGTGGCTGAGTATCGAAC	0.502000													21	44					0	0	0	0
MYOCD	93649	broad.mit.edu	37	17	12655998	12655998	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:12655998C>T	uc002gnn.2	+	10	1692	c.1393C>T	c.(1393-1395)CTG>TTG	p.L465L	MYOCD_uc002gno.2_Silent_p.L465L|MYOCD_uc002gnp.1_Silent_p.L369L|MYOCD_uc002gnq.2_Silent_p.L184L	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	465	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CTCCTCTGACCTGTCAGTCGC	0.612000													18	79					0	0	0	0
ULK2	9706	broad.mit.edu	37	17	19698941	19698941	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:19698941C>G	uc002gwm.3	-	20	2604	c.2095G>C	c.(2095-2097)GAT>CAT	p.D699H	ULK2_uc002gwn.2_Missense_Mutation_p.D699H	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	699					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					TTACCTATATCCATTGGTCGT	0.294000													43	65					0	0	0	0
ULK2	9706	broad.mit.edu	37	17	19699443	19699443	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:19699443C>T	uc002gwm.3	-	19	2471	c.1962G>A	c.(1960-1962)CAG>CAA	p.Q654Q	ULK2_uc002gwn.2_Silent_p.Q654Q	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	654					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GCTCGGCCCGCTGCCTCTCAC	0.473000													37	47					0	0	0	0
DHRS13	147015	broad.mit.edu	37	17	27228113	27228113	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:27228113C>A	uc002hde.3	-	4	704	c.577G>T	c.(577-579)GAG>TAG	p.E193*	DHRS13_uc002hdd.3_Nonsense_Mutation_p.E143*|DHRS13_uc010wba.1_Nonsense_Mutation_p.E112*	NM_144683	NP_653284	Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	193						extracellular region	binding|oxidoreductase activity				0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			GCCCGCAGCTCCTGCCGCCAG	0.632000													18	39					4.35082e-09	4.98597e-09	1	0
MMP28	79148	broad.mit.edu	37	17	34093598	34093598	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:34093598G>C	uc002hjy.1	-	10	1743	c.1484C>G	c.(1483-1485)GCA>GGA	p.A495G	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	495	Hemopexin-like 4.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		CGAGGTGGTTGCCTGCAGTTT	0.662000													3	12					0	0	0	0
DDX52	11056	broad.mit.edu	37	17	35986901	35986901	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:35986901G>C	uc002hoi.1	-	7	903	c.865C>G	c.(865-867)CTT>GTT	p.L289V	DDX52_uc002hoh.1_Missense_Mutation_p.L181V	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a	289	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				GTAGTCACAAGAATATCTATA	0.358000													9	34					0	0	0	0
ZPBP2	124626	broad.mit.edu	37	17	38032946	38032946	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:38032946C>G	uc002hte.2	+	8	1054	c.901C>G	c.(901-903)CCT>GCT	p.P301A	ZPBP2_uc002htf.2_Missense_Mutation_p.P279A	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	301					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGTTTGTAGTCCTGCGACTTT	0.373000													24	89					0	0	0	0
KRT10	3858	broad.mit.edu	37	17	38976763	38976763	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:38976763C>G	uc002hvi.2	-	3	893	c.867G>C	c.(865-867)GAG>GAC	p.E289D	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	289	Coil 1B.|Rod.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				TTTGTGTCACCTCCTCGTGGT	0.468000													9	67					0	0	0	0
Unknown	0	broad.mit.edu	37	17	39296282	39296282	+	RNA	SNP	G	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:39296282G>T	uc010cxk.1	-	1		c.422C>A								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		ttcacagcaagaggggcggca	0.323000													3	23					0.00024832	0.000261653	1	0
FZD2	2535	broad.mit.edu	37	17	42636331	42636331	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:42636331C>G	uc002igx.1	+	1	1407	c.1275C>G	c.(1273-1275)TTC>TTG	p.F425L		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	425	Helical; Name=5; (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGTACCTGTTCATCGGCACGT	0.637000													12	51					0	0	0	0
INTS2	57508	broad.mit.edu	37	17	59962319	59962319	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:59962319G>C	uc002izn.2	-	16	2132	c.2056C>G	c.(2056-2058)CAG>GAG	p.Q686E	INTS2_uc002izm.2_Missense_Mutation_p.Q678E	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	686					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						ATAGGAATCTGATCCATTAAA	0.333000													7	7					0	0	0	0
SGSH	6448	broad.mit.edu	37	17	78184560	78184560	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr17:78184560C>T	uc002jxz.3	-	8	1287	c.1200G>A	c.(1198-1200)CAG>CAA	p.Q400Q	SGSH_uc002jya.3_Silent_p.Q197Q|SGSH_uc002jxy.2_3'UTR	NM_000199	NP_000190	P51688	SPHM_HUMAN	N-sulfoglucosamine sulfohydrolase precursor	400					proteoglycan metabolic process	lysosome	metal ion binding|N-sulfoglucosamine sulfohydrolase activity|sulfuric ester hydrolase activity			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CGTAGAAGTCCTGGTCGATGG	0.602000													25	46					0	0	0	0
FBN3	84467	broad.mit.edu	37	19	8154783	8154783	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:8154783C>A	uc002mjf.2	-	49	6266	c.6245G>T	c.(6244-6246)CGA>CTA	p.R2082L	FBN3_uc002mje.2_5'UTR	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2082						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CTCACCTTCTCGGGAGTCATC	0.647000													5	3					1.23904e-05	1.3509e-05	1	0
CACNA1A	773	broad.mit.edu	37	19	13409899	13409899	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:13409899C>T	uc010dze.2	-	19	2787	c.2551G>A	c.(2551-2553)GGC>AGC	p.G851S	CACNA1A_uc010dzc.2_Missense_Mutation_p.G376S|CACNA1A_uc002mwy.3_Missense_Mutation_p.G850S|CACNA1A_uc010xne.1_Missense_Mutation_p.G379S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	851	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGCTGCTGGCCGAGGCGCTGG	0.721000													10	10					0	0	0	0
BRD4	23476	broad.mit.edu	37	19	15355574	15355574	+	Splice_Site	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:15355574C>T	uc002nar.2	-	12	2381	c.2159_splice	c.e12-1	p.E720_splice		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long						interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GGAGCCATCTCTGCAGAGGAA	0.547000			T	NUT|C15orf55	lethal midline carcinoma of young people								37	75					0	0	0	0
ZNF382	84911	broad.mit.edu	37	19	37117054	37117054	+	Silent	SNP	T	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:37117054T>C	uc002oek.2	+	5	368	c.255T>C	c.(253-255)GAT>GAC	p.D85D	ZNF382_uc010efa.2_Silent_p.D36D|ZNF382_uc010efb.2_Silent_p.D84D|ZNF382_uc002oel.2_Silent_p.D84D	NM_032825	NP_116214	Q96SR6	ZN382_HUMAN	zinc finger protein 382	85	Mediates interaction with TRIM28 (By similarity).|Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AAACTGAAGATGTCTTAGTGA	0.343000													16	36					0	0	0	0
EPN1	29924	broad.mit.edu	37	19	56203256	56203256	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:56203256C>T	uc002qlw.2	+	7	1241	c.899C>T	c.(898-900)CCT>CTT	p.P300L	EPN1_uc002qlv.2_Missense_Mutation_p.P275L|EPN1_uc010etd.2_Missense_Mutation_p.P300L|EPN1_uc002qlx.2_Missense_Mutation_p.P386L	NM_001130072	NP_001123544	Q9Y6I3	EPN1_HUMAN	epsin 1 isoform b	300	Ala/Gly/Pro-rich.|8 X 3 AA repeats of [ED]-P-W.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding				0		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		GGCGGCCCCCCTGTCCCTCCA	0.751000													12	37					0	0	0	0
ZNF324B	388569	broad.mit.edu	37	19	58965127	58965127	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr19:58965127C>G	uc002qsv.1	+	2	166	c.59C>G	c.(58-60)ACA>AGA	p.T20R	ZNF324B_uc002qsu.1_5'UTR|ZNF324B_uc010euq.1_Missense_Mutation_p.T20R	NM_207395	NP_997278	Q6AW86	Z324B_HUMAN	zinc finger protein 324B	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CTCCTGGACACAGCGCAGAGG	0.572000													21	49					0	0	0	0
ADAM17	6868	broad.mit.edu	37	2	9642395	9642395	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:9642395T>A	uc002qzu.2	-	13	1738	c.1555A>T	c.(1555-1557)AGT>TGT	p.S519C	ADAM17_uc010ewy.2_Missense_Mutation_p.S519C|ADAM17_uc010ewz.2_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	519	Disintegrin.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		CAGCAAGGACTGTTCCTGTCA	0.468000													43	40					0	0	0	0
YWHAQ	10971	broad.mit.edu	37	2	9728378	9728378	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:9728378G>C	uc002qzw.2	-	3	662	c.498C>G	c.(496-498)ATC>ATG	p.I166M	YWHAQ_uc002qzx.2_Missense_Mutation_p.I166M	NM_006826	NP_006817	P27348	1433T_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	166					negative regulation of transcription, DNA-dependent	centrosome|nucleus	protein N-terminus binding			breast(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.241)		GCCCCAGGCGGATTGGGTGTG	0.428000													26	21					0	0	0	0
C2orf16	84226	broad.mit.edu	37	2	27803934	27803934	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:27803934G>C	uc002rkz.3	+	1	4546	c.4495G>C	c.(4495-4497)GAG>CAG	p.E1499Q	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1499										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					CTCCAGCCAGGAGTCTAAGAA	0.478000													34	71					0	0	0	0
ALK	238	broad.mit.edu	37	2	30143411	30143411	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:30143411G>A	uc002rmy.2	-	1	1022	c.115C>T	c.(115-117)CAG>TAG	p.Q39*		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	39	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TCCCGGGGCTGCAGCGGCGGC	0.706000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				4	12					0	0	0	0
HEATR5B	54497	broad.mit.edu	37	2	37310507	37310507	+	Silent	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:37310507G>A	uc002rpp.1	-	2	147	c.51C>T	c.(49-51)ATC>ATT	p.I17I	CCDC75_uc010ezz.2_5'Flank|CCDC75_uc002rpr.3_5'Flank	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	17							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				TTGCTTCGGTGATTTGAGCCA	0.363000													14	38					0	0	0	0
GPR39	2863	broad.mit.edu	37	2	133402786	133402786	+	Missense_Mutation	SNP	G	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:133402786G>T	uc002ttl.2	+	2	1438	c.969G>T	c.(967-969)ATG>ATT	p.M323I	LYPD1_uc002ttm.3_3'UTR|LYPD1_uc002ttn.2_3'UTR|LYPD1_uc002tto.2_3'UTR	NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	323	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						GGGCGTACATGATCCTCCTCC	0.587000													21	45					1.9806e-07	2.2211e-07	1	0
SCRN3	79634	broad.mit.edu	37	2	175263019	175263019	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:175263019C>A	uc002uiq.2	+	2	96	c.8C>A	c.(7-9)CCT>CAT	p.P3H	CIR1_uc002uim.2_5'Flank|CIR1_uc002uin.2_5'Flank|CIR1_uc002uio.2_5'Flank|CIR1_uc002uip.2_5'Flank|SCRN3_uc010zen.1_Intron|SCRN3_uc010zeo.1_5'UTR|SCRN3_uc002uir.1_RNA	NM_024583	NP_078859	Q0VDG4	SCRN3_HUMAN	secernin 3	3					proteolysis		dipeptidase activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.229)			AAAATGGAACCTTTTTCCTGT	0.289000													6	55					0.00116845	0.00121487	1	0
GPR155	151556	broad.mit.edu	37	2	175330545	175330545	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:175330545T>C	uc002uit.2	-	8	1743	c.1352A>G	c.(1351-1353)TAC>TGC	p.Y451C	GPR155_uc002uiu.2_Missense_Mutation_p.Y451C|GPR155_uc002uiv.2_Missense_Mutation_p.Y451C|GPR155_uc010fqs.2_Missense_Mutation_p.Y423C	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	451	Helical; (Potential).				intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						GAGGGAGCTGTACAATAGAAC	0.388000													5	15					0	0	0	0
MSTN	2660	broad.mit.edu	37	2	190927237	190927237	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:190927237T>C	uc002urp.2	-	1	219	c.86A>G	c.(85-87)CAA>CGA	p.Q29R		NM_005259	NP_005250	O14793	GDF8_HUMAN	myostatin precursor	29					muscle organ development|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			lung(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000742)|Epithelial(96;0.0121)|all cancers(119;0.0395)			ATTTTCTTTTTGCTCACTGTT	0.348000													35	74					0	0	0	0
CLK1	1195	broad.mit.edu	37	2	201726085	201726085	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:201726085C>G	uc002uwe.2	-	3	447	c.266G>C	c.(265-267)CGC>CCC	p.R89P	CLK1_uc010zhi.1_Missense_Mutation_p.R131P|CLK1_uc002uwf.2_5'UTR|CLK1_uc002uwg.2_5'UTR|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	89					cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						GTCTCTTTGGCGATGTCCAGG	0.403000													50	101					0	0	0	0
USP37	57695	broad.mit.edu	37	2	219362475	219362475	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:219362475G>C	uc002vie.2	-	13	1716	c.1263C>G	c.(1261-1263)TTC>TTG	p.F421L	USP37_uc010fvs.1_Missense_Mutation_p.F421L|USP37_uc010zkf.1_Missense_Mutation_p.F421L|USP37_uc002vif.2_Missense_Mutation_p.F421L|USP37_uc002vig.2_Missense_Mutation_p.F349L	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	421					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TATAACCAGAGAATCTCTCTG	0.244000													21	38					0	0	0	0
C2orf83	56918	broad.mit.edu	37	2	228476316	228476316	+	Missense_Mutation	SNP	C	T	T	rs111332429	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:228476316C>T	uc002vph.2	-	3	482	c.247G>A	c.(247-249)GTA>ATA	p.V83I	C2orf83_uc010zlu.1_3'UTR	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	83						membrane	folic acid binding|reduced folate carrier activity				0						CATGTCTGTACGGTAAGTTTC	0.468000													22	38					0	0	0	0
DNER	92737	broad.mit.edu	37	2	230272008	230272008	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:230272008C>G	uc002vpv.2	-	10	1810	c.1663G>C	c.(1663-1665)GGA>CGA	p.G555R		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	555	Extracellular (Potential).|Follistatin-like.|EGF-like 9.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CAGGTGGCTCCGTTCAGACAG	0.512000													18	79					0	0	0	0
STK25	10494	broad.mit.edu	37	2	242441064	242441064	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:242441064C>T	uc002wbm.2	-	2	361	c.90G>A	c.(88-90)TCG>TCA	p.S30S	STK25_uc002wbk.2_5'Flank|STK25_uc002wbl.2_5'Flank|STK25_uc002wbn.2_Silent_p.S30S|STK25_uc002wbo.2_Intron|STK25_uc010zos.1_5'UTR|STK25_uc010zot.1_5'UTR|STK25_uc002wbp.2_Silent_p.S30S|STK25_uc010fzo.2_Intron|STK25_uc010zou.1_5'UTR|STK25_uc010zov.1_5'UTR|STK25_uc010zow.1_Silent_p.S30S	NM_006374	NP_006365	O00506	STK25_HUMAN	serine/threonine kinase 25	30	ATP (By similarity).|Protein kinase.				response to oxidative stress|signal transduction	Golgi apparatus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;8.24e-34)|all cancers(36;3.46e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.6e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.1e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0839)		CCTCCCCAAACGAGCCCTTGC	0.612000													5	73					0	0	0	0
C20orf117	140710	broad.mit.edu	37	20	35444329	35444329	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr20:35444329C>G	uc002xgd.1	-	5	1129	c.802G>C	c.(802-804)GGG>CGG	p.G268R	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	268											0		Myeloproliferative disorder(115;0.00874)				AAGCTCTCCCCGCACTCTCCG	0.662000													4	5					0	0	0	0
PRDM15	63977	broad.mit.edu	37	21	43258051	43258051	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr21:43258051C>T	uc002yzq.1	-	15	2202	c.2091G>A	c.(2089-2091)TCG>TCA	p.S697S	PRDM15_uc002yzo.2_Silent_p.S368S|PRDM15_uc002yzp.2_Silent_p.S368S|PRDM15_uc002yzr.1_Silent_p.S368S	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	697					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACTTTGGAACCGAGCTGGTGT	0.627000													23	52					0	0	0	0
POTEH	23784	broad.mit.edu	37	22	16279217	16279217	+	Missense_Mutation	SNP	T	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:16279217T>A	uc010gqp.2	-	4	1058	c.1006A>T	c.(1006-1008)AAT>TAT	p.N336Y	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.N55Y|POTEH_uc002zlj.1_Missense_Mutation_p.N171Y	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	336	ANK 5.									skin(1)	1						TCCAGTGCATTTAAATTTGCT	0.313000													29	221					0	0	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130547	20130547	+	Missense_Mutation	SNP	T	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:20130547T>C	uc002zrq.2	+	10	1500	c.1394T>C	c.(1393-1395)TTT>TCT	p.F465S	ZDHHC8_uc002zrr.1_Missense_Mutation_p.F465S|ZDHHC8_uc010gsa.2_Missense_Mutation_p.F271S	NM_013373	NP_037505	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC domain containing 8	465	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Colorectal(54;0.0993)					CGTAGCATTTTTGCCCCCCAT	0.701000													6	62					0	0	0	0
LIF	3976	broad.mit.edu	37	22	30639706	30639706	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:30639706C>G	uc003agz.2	-	3	655	c.543G>C	c.(541-543)AAG>AAC	p.K181N	LIF_uc011aks.1_3'UTR|uc003aha.2_5'Flank	NM_002309	NP_002300	P15018	LIF_HUMAN	leukemia inhibitory factor (cholinergic	181					immune response|leukemia inhibitory factor signaling pathway|negative regulation of hormone secretion|positive regulation of cell proliferation|positive regulation of macrophage differentiation|positive regulation of MAPKKK cascade|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of metanephric nephron tubule epithelial cell differentiation		cytokine activity|growth factor activity|leukemia inhibitory factor receptor binding				0			Epithelial(10;0.171)			AGCCCAGCTTCTTCTTCTGGA	0.572000													30	87					0	0	0	0
GGA1	26088	broad.mit.edu	37	22	38016337	38016337	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:38016337C>G	uc003atc.2	+	5	761	c.396C>G	c.(394-396)ATC>ATG	p.I132M	GGA1_uc003atd.2_Missense_Mutation_p.I132M|GGA1_uc003ate.2_Missense_Mutation_p.I132M|GGA1_uc003atf.2_Missense_Mutation_p.I59M	NM_013365	NP_037497	Q9UJY5	GGA1_HUMAN	golgi associated, gamma adaptin ear containing,	132	Interaction with ARF3.|VHS.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|Golgi apparatus part	protein binding			breast(2)|ovary(1)	3	Melanoma(58;0.0574)					AGGTGAAAATCGCAGAGGCCT	0.612000													24	84					0	0	0	0
CSNK1E	1454	broad.mit.edu	37	22	38694865	38694865	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr22:38694865G>C	uc003avj.2	-	7	1072	c.811C>G	c.(811-813)CAG>GAG	p.Q271E	CSNK1E_uc003avk.2_Missense_Mutation_p.Q271E|CSNK1E_uc003avl.1_RNA|CSNK1E_uc003avm.1_Missense_Mutation_p.Q271E|CSNK1E_uc003avo.2_Missense_Mutation_p.Q271E|CSNK1E_uc003avp.1_Missense_Mutation_p.Q271E|CSNK1E_uc003avq.1_Missense_Mutation_p.Q271E	NM_152221	NP_689407	P49674	KC1E_HUMAN	casein kinase 1 epsilon	271	Protein kinase.				DNA repair|G2/M transition of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|signal transduction	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Melanoma(58;0.045)					CGGAAGAGCTGACGTAGGTAA	0.547000											OREG0026559	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	122					0	0	0	0
TTC14	151613	broad.mit.edu	37	3	180328289	180328289	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:180328289G>A	uc003fkk.2	+	12	2404	c.2272G>A	c.(2272-2274)GCT>ACT	p.A758T	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	758							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TAATCAGATAGCTGAATTTGA	0.313000													8	86					0	0	0	0
MCF2L2	23101	broad.mit.edu	37	3	183006931	183006931	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:183006931C>T	uc003fli.1	-	14	1843	c.1753G>A	c.(1753-1755)GAT>AAT	p.D585N	MCF2L2_uc003flj.1_Missense_Mutation_p.D585N|MCF2L2_uc011bqr.1_RNA|uc003fln.1_Intron	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	585					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TTAGTCTCATCATCTTCCTTT	0.403000													21	33					0	0	0	0
MIR1248	100302143	broad.mit.edu	37	3	186504469	186504469	+	RNA	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:186504469C>T	hsa-mir-1248|MI0006383	+			c.9C>T			EIF4A2_uc003fqs.2_Intron|EIF4A2_uc003fqt.2_Intron|EIF4A2_uc003fqu.2_Intron|EIF4A2_uc003fqv.2_Intron|EIF4A2_uc003fqw.2_Intron|EIF4A2_uc011bsb.1_Intron|SNORA81_uc010hyv.1_RNA|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank																	0						ATTTTACCTTCTTGTATAAGC	0.358000													50	82					0	0	0	0
MUC4	4585	broad.mit.edu	37	3	195516484	195516484	+	Missense_Mutation	SNP	G	C	C	rs3749330	by1000genomes	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:195516484G>C	uc011bto.1	-	2	2427	c.1967C>G	c.(1966-1968)TCC>TGC	p.S656C	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.S538C	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	661					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGTCATGGGGGAGACGGACCT	0.562000													12	172					0	0	0	0
FAM193A	8603	broad.mit.edu	37	4	2717749	2717749	+	Splice_Site	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:2717749G>C	uc010icl.2	+	19	3974	c.3623_splice	c.e19-1	p.D1208_splice	FAM193A_uc010ick.2_Splice_Site_p.D1367_splice|FAM193A_uc003gfd.2_Splice_Site_p.D1167_splice|FAM193A_uc011bvm.1_Splice_Site_p.D1189_splice|FAM193A_uc011bvn.1_Splice_Site_p.D1167_splice|FAM193A_uc011bvo.1_Splice_Site|FAM193A_uc010icm.2_Splice_Site	NM_003704	NP_003695	P78312	F193A_HUMAN	hypothetical protein LOC8603											ovary(3)	3						TTGTTTTACAGATGATGTCTT	0.378000													28	52					0	0	0	0
RBPJ	3516	broad.mit.edu	37	4	26432465	26432465	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:26432465G>C	uc003grx.1	+	12	1575	c.1339G>C	c.(1339-1341)GAA>CAA	p.E447Q	RBPJ_uc003gry.1_Missense_Mutation_p.E432Q|RBPJ_uc003grz.1_Missense_Mutation_p.E447Q|RBPJ_uc003gsa.1_Missense_Mutation_p.E433Q|RBPJ_uc003gsb.1_Missense_Mutation_p.E434Q|RBPJ_uc003gsc.1_3'UTR|uc003gsd.2_5'Flank	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	447					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				CTACACACCAGAACCAGGGCC	0.527000													17	41					0	0	0	0
LPHN3	23284	broad.mit.edu	37	4	62849282	62849282	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:62849282C>T	uc010ihh.2	+	16	3166	c.2993C>T	c.(2992-2994)TCA>TTA	p.S998L	LPHN3_uc003hcq.3_Missense_Mutation_p.S998L|LPHN3_uc003hct.2_Missense_Mutation_p.S391L	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	985	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GTGGCTGTGTCAGCTGCAGTA	0.383000													36	90					0	0	0	0
UGT2B4	7363	broad.mit.edu	37	4	70360953	70360953	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:70360953C>T	uc003hek.3	-	1	674	c.627G>A	c.(625-627)GAG>GAA	p.E209E	UGT2B4_uc011cap.1_Silent_p.E73E|UGT2B4_uc003hel.3_Silent_p.E209E	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	209					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TTTTTACCCTCTCTATGAAAG	0.378000													11	29					0	0	0	0
ENAM	10117	broad.mit.edu	37	4	71509483	71509483	+	Silent	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:71509483G>A	uc011caw.1	+	9	2621	c.2340G>A	c.(2338-2340)CCG>CCA	p.P780P		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	780					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			AAAGAAGGCCGTATTTTAACA	0.473000													20	35					0	0	0	0
Unknown	0	broad.mit.edu	37	4	88813216	88813216	+	Silent	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:88813216C>T	uc010iko.1	+	1	222	c.222C>T	c.(220-222)GAC>GAT	p.D74D						SubName: Full=Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a; SubName: Full=cDNA, FLJ92550, Homo sapiens heat shock 90kDa protein 1, beta (HSPCB), mRNA;																		TGAAAATTGACATCATCCCCA	0.453000													9	35					0	0	0	0
FBXW7	55294	broad.mit.edu	37	4	153247255	153247255	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr4:153247255C>T	uc003ims.2	-	10	1696	c.1547G>A	c.(1546-1548)AGT>AAT	p.S516N	FBXW7_uc011cii.1_Missense_Mutation_p.S516N|FBXW7_uc003imt.2_Missense_Mutation_p.S516N|FBXW7_uc011cih.1_Missense_Mutation_p.S340N|FBXW7_uc003imq.2_Missense_Mutation_p.S436N|FBXW7_uc003imr.2_Missense_Mutation_p.S398N	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	516	WD 4.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATATGCTCCACTAACAACCCT	0.443000			Mis|N|D|F		colorectal|endometrial|T-ALL								22	122					0	0	0	0
HSPA4	3308	broad.mit.edu	37	5	132427046	132427046	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr5:132427046C>T	uc003kyj.2	+	12	1821	c.1540C>T	c.(1540-1542)CAG>TAG	p.Q514*		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	514					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGAAACAGATCAGAATGCAAA	0.438000													11	13					0	0	0	0
HIST1H1D	3007	broad.mit.edu	37	6	26234945	26234945	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:26234945C>T	uc003nhd.2	-	1	272	c.217G>A	c.(217-219)GAT>AAT	p.D73N		NM_005320	NP_005311	P16402	H13_HUMAN	histone cluster 1, H1d	73	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			skin(1)	1		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				TTTTCTACATCGTAGCCAGCA	0.542000													34	80					0	0	0	0
SH3BGRL2	83699	broad.mit.edu	37	6	80383466	80383466	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:80383466C>G	uc003piz.1	+	2	360	c.181C>G	c.(181-183)CAG>GAG	p.Q61E		NM_031469	NP_113657	Q9UJC5	SH3L2_HUMAN	SH3 domain binding glutamic acid-rich protein	61	SH3-binding (Potential).					nucleus	SH3 domain binding				0		all_cancers(76;0.00188)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.174)		BRCA - Breast invasive adenocarcinoma(397;0.0278)		GAAACCCACTCAGGGCAACCC	0.458000													27	60					0	0	0	0
MAP3K7	6885	broad.mit.edu	37	6	91246083	91246083	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:91246083C>G	uc003pnz.1	-	13	1491	c.1329G>C	c.(1327-1329)TTG>TTC	p.L443F	MAP3K7_uc003pny.1_5'UTR|MAP3K7_uc003poa.1_Missense_Mutation_p.L443F|MAP3K7_uc003pob.1_Missense_Mutation_p.L416F|MAP3K7_uc003poc.1_Missense_Mutation_p.L416F	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	443					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		CAGTTACAGTCAAGTCTTGGA	0.343000													13	28					0	0	0	0
REV3L	5980	broad.mit.edu	37	6	111680071	111680071	+	Silent	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:111680071G>A	uc003puy.3	-	17	7349	c.7026C>T	c.(7024-7026)CTC>CTT	p.L2342L	REV3L_uc003pux.3_Silent_p.L2264L|REV3L_uc003puz.3_Silent_p.L2264L|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2342					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TTACACCTGTGAGTTCTGTTT	0.398000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					26	58					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117708099	117708099	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:117708099C>T	uc003pxp.1	-	14	2277	c.2078G>A	c.(2077-2079)AGC>AAC	p.S693N	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	693	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGGGCCAAAGCTATTTAATGG	0.383000			T	GOPC|ROS1	glioblastoma|NSCLC								29	50					0	0	0	0
SNX9	51429	broad.mit.edu	37	6	158330947	158330947	+	Missense_Mutation	SNP	A	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:158330947A>G	uc003qqv.1	+	9	1012	c.839A>G	c.(838-840)AAT>AGT	p.N280S		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	280	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		TAGAACACTAATCGATCTGTA	0.393000													32	56					0	0	0	0
WTAP	9589	broad.mit.edu	37	6	160176488	160176488	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:160176488G>A	uc003qsl.2	+	8	1258	c.1036G>A	c.(1036-1038)GAA>AAA	p.E346K	WTAP_uc003qso.2_Missense_Mutation_p.E227K	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	346					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		CACGGGCAGTGAAAACTCTCT	0.507000													24	41					0	0	0	0
MSRA	4482	broad.mit.edu	37	8	10285683	10285683	+	Missense_Mutation	SNP	C	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:10285683C>T	uc003wsx.2	+	6	766	c.569C>T	c.(568-570)CCC>CTC	p.P190L	MSRA_uc011kwx.1_Missense_Mutation_p.P150L|MSRA_uc003wsz.2_Missense_Mutation_p.P147L|MSRA_uc003wsy.2_Missense_Mutation_p.P124L	NM_012331	NP_036463	Q9UJ68	MSRA_HUMAN	methionine sulfoxide reductase A isoform a	190					methionine metabolic process|protein modification process|response to oxidative stress	mitochondrion|nucleus	peptide-methionine-(S)-S-oxide reductase activity				0		Myeloproliferative disorder(644;0.178)			L-Methionine(DB00134)	GGCTTCGGCCCCATCACTACC	0.597000													14	26					0	0	0	0
FAM160B2	64760	broad.mit.edu	37	8	21958395	21958395	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:21958395G>A	uc011kyx.1	+	12	1579	c.1528G>A	c.(1528-1530)GAT>AAT	p.D510N	FAM160B2_uc011kyy.1_RNA	NM_022749	NP_073586	Q86V87	F16B2_HUMAN	retinoic acid induced 16	510											0						CAGCTTCCTGGATTCCGGCTT	0.572000													34	78					0	0	0	0
ADAM7	8756	broad.mit.edu	37	8	24326281	24326281	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:24326281G>A	uc003xeb.2	+	7	694	c.581G>A	c.(580-582)GGC>GAC	p.G194D		NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	194	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ACTTTACAGGGCATCCATGAT	0.308000													3	41					0	0	0	0
IKBKB	3551	broad.mit.edu	37	8	42176820	42176820	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:42176820C>G	uc003xow.1	+	14	1574	c.1397C>G	c.(1396-1398)TCC>TGC	p.S466C	IKBKB_uc010lxh.1_Missense_Mutation_p.S361C|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Missense_Mutation_p.S243C|IKBKB_uc003xox.1_Missense_Mutation_p.S187C|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Missense_Mutation_p.S464C|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Missense_Mutation_p.S407C	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	466	Leucine-zipper.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	AGCTGCCTCTCCAAAATGAAG	0.473000											OREG0018747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	93					0	0	0	0
PAG1	55824	broad.mit.edu	37	8	81897257	81897257	+	Silent	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:81897257C>G	uc003ybz.2	-	7	1341	c.630G>C	c.(628-630)TCG>TCC	p.S210S		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	210	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GGAGCTCTTTCGAGGCAGAAG	0.488000													23	49					0	0	0	0
UBR5	51366	broad.mit.edu	37	8	103301699	103301699	+	Silent	SNP	A	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:103301699A>T	uc003ykr.1	-	35	4728	c.4695T>A	c.(4693-4695)GTT>GTA	p.V1565V	UBR5_uc003yks.1_Silent_p.V1565V	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1565					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CATCTGCTGAAACAATATCAT	0.403000													16	61					0	0	0	0
EIF3E	3646	broad.mit.edu	37	8	109254111	109254111	+	Missense_Mutation	SNP	T	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:109254111T>G	uc003ymu.2	-	2	150	c.122A>C	c.(121-123)AAA>ACA	p.K41T	EIF3E_uc003ymt.2_5'UTR|EIF3E_uc003ymv.2_Intron|EIF3E_uc010mci.1_Missense_Mutation_p.K41T|EIF3E_uc010mcj.1_Missense_Mutation_p.K41T	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	41	Sufficient for interaction with TRIM27.|Sufficient for interaction with EPAS1.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			AAGGTCCAATTTACCTTGTAA	0.284000													10	41					0	0	0	0
OPLAH	26873	broad.mit.edu	37	8	145107094	145107094	+	Missense_Mutation	SNP	C	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr8:145107094C>A	uc003zar.3	-	24	3521	c.3439G>T	c.(3439-3441)GAC>TAC	p.D1147Y		NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	1147							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	ATCTCAGGGTCGGTGATGCGT	0.622000													6	6					3.59834e-05	3.86944e-05	1	0
ABCA2	20	broad.mit.edu	37	9	139907546	139907546	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr9:139907546G>C	uc011mem.1	-	29	4920	c.4772C>G	c.(4771-4773)CCC>CGC	p.P1591R	ABCA2_uc011mel.1_Missense_Mutation_p.P1592R|ABCA2_uc004ckl.1_Missense_Mutation_p.P1522R|ABCA2_uc004ckm.1_Missense_Mutation_p.P1622R|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1591					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGAGGGTGGGGGTGGCACGAA	0.677000													13	1					0	0	0	0
FAM123B	139285	broad.mit.edu	37	X	63412439	63412439	+	Missense_Mutation	SNP	G	A	A			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:63412439G>A	uc004dvo.2	-	2	1001	c.728C>T	c.(727-729)CCA>CTA	p.P243L		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	243					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						AGAAGGTTCTGGTGTTGGAGA	0.542000													47	30					0	0	0	0
MED12	9968	broad.mit.edu	37	X	70338616	70338616	+	Missense_Mutation	SNP	C	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:70338616C>G	uc004dyy.2	+	1	211	c.12C>G	c.(10-12)TTC>TTG	p.F4L	MED12_uc011mpq.1_Missense_Mutation_p.F4L|MED12_uc004dyz.2_Missense_Mutation_p.F4L|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	4					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGGCGGCCTTCGGGATCTTGA	0.672000													8	4					0	0	0	0
MID2	11043	broad.mit.edu	37	X	107084609	107084609	+	Silent	SNP	A	G	G			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:107084609A>G	uc004enl.2	+	2	1287	c.714A>G	c.(712-714)AAA>AAG	p.K238K	MID2_uc004enk.2_Silent_p.K238K	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	238	Potential.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						GATTTGAGAAACTCAAGGTAA	0.433000													13	14					0	0	0	0
FRMD7	90167	broad.mit.edu	37	X	131212868	131212868	+	Missense_Mutation	SNP	G	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chrX:131212868G>C	uc004ewn.2	-	12	1355	c.1177C>G	c.(1177-1179)CTG>GTG	p.L393V	FRMD7_uc011muy.1_Missense_Mutation_p.L378V	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	393					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GAatgctccagctcagttgca	0.284000													71	38					0	0	0	0
Unknown	0	broad.mit.edu	37	1	160640798	160640798	+	IGR	DEL	T	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr1:160640798delT								SLAMF1 (23717 upstream) : CD48 (7740 downstream)																							TTCTGAACAATTTTTTTTTTA	0.264													---	---	---							
AHNAK	79026	broad.mit.edu	37	11	62299831	62299831	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr11:62299831delC	uc001ntl.2	-	5	2358	c.2058delG	c.(2056-2058)AAGfs	p.K686fs	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	686					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TATCAGGCAGCTTAACATCGG	0.473													---	---	---							
METTL1	4234	broad.mit.edu	37	12	58162860	58162879	+	Frame_Shift_Del	DEL	CTTCCCTCCATTACGTAGAA	-	-	rs140194153	byFrequency	TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:58162860_58162879delCTTCCCTCCATTACGTAGAA	uc010ssd.1	-	6	779_798	c.731_750delTTCTACGTAATGGAGGGAAG	c.(730-750)GTTCTACGTAATGGAGGGAAGfs	p.V244fs	CYP27B1_uc001spz.1_5'Flank|CYP27B1_uc001sqa.1_5'Flank|METTL1_uc009zqc.2_3'UTR	NM_005371	NP_005362	Q9UBP6	TRMB_HUMAN	methyltransferase-like protein 1 isoform a	244_250						cytoplasm|nucleus	protein binding|tRNA (guanine-N7-)-methyltransferase activity|tRNA binding				0	all_cancers(7;6.73e-81)|Lung NSC(6;1.07e-25)|all_lung(6;8.25e-24)|all_epithelial(6;4.6e-17)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.211)			CTGGGAAATTCTTCCCTCCATTACGTAGAACTTTCTTCCC	0.527													---	---	---							
NOS1	4842	broad.mit.edu	37	12	117703229	117703230	+	Frame_Shift_Ins	INS	-	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr12:117703229_117703230insC	uc001twm.1	-	12	2713_2714	c.2027_2028insG	c.(2026-2028)GGCfs	p.G676fs		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	676					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CGGCAGGGCAGCCCCCCCGGCA	0.604													---	---	---							
UTP14C	9724	broad.mit.edu	37	13	52603224	52603229	+	In_Frame_Del	DEL	CTTCAT	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr13:52603224_52603229delCTTCAT	uc001vgb.2	+	2	819_824	c.284_289delCTTCAT	c.(283-291)ACTTCATCT>ACT	p.SS96del	UTP14C_uc001vga.2_3'UTR|UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	96_97					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		CCCGTTAAAACTTCATCTTCTTTGGC	0.427													---	---	---							
SLC22A17	51310	broad.mit.edu	37	14	23821365	23821365	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr14:23821365delA	uc001wjl.2	-	1	115	c.59delT	c.(58-60)TTCfs	p.F20fs	SLC22A17_uc010akk.2_5'UTR|SLC22A17_uc001wjn.2_RNA|SLC22A17_uc001wjm.2_Frame_Shift_Del_p.F20fs|SLC22A17_uc010akl.1_Frame_Shift_Del_p.F20fs	NM_020372	NP_065105	Q8WUG5	S22AH_HUMAN	solute carrier family 22, member 17 isoform a	20					siderophore transport	integral to organelle membrane|integral to plasma membrane|vacuolar membrane	transmembrane receptor activity|transmembrane transporter activity				0	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00643)		ATTAGGGGGGAAGGCCCCGTA	0.711													---	---	---							
DNAH3	55567	broad.mit.edu	37	16	21086866	21086878	+	Frame_Shift_Del	DEL	CACCAATGGGCTC	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:21086866_21086878delCACCAATGGGCTC	uc010vbe.1	-	21	2974_2986	c.2974_2986delGAGCCCATTGGTG	c.(2974-2988)GAGCCCATTGGTGCAfs	p.E992fs		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	992_996	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTGGCAGCTGCACCAATGGGCTCCAATCTAAAG	0.399													---	---	---							
Unknown	0	broad.mit.edu	37	16	33396129	33396130	+	IGR	INS	-	C	C			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:33396129_33396130insC								SLC6A10P (499666 upstream) : MIR1826 (569378 downstream)																							GCACCAGGTGACCCCCCCACTG	0.554													---	---	---							
TERF2	7014	broad.mit.edu	37	16	69400835	69400843	+	In_Frame_Del	DEL	GACCAATCT	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr16:69400835_69400843delGACCAATCT	uc002exd.2	-	7	1206_1214	c.1081_1089delAGATTGGTC	c.(1081-1089)AGATTGGTCdel	p.RLV361del		NM_005652	NP_005643	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	361_363					age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			lung(1)	1		Ovarian(137;0.101)				CCTCCTCCAAGACCAATCTGCTTATTGTC	0.569													---	---	---							
Unknown	0	broad.mit.edu	37	2	64603271	64603272	+	IGR	INS	-	ACC	ACC			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr2:64603271_64603272insACC								PELI1 (231666 upstream) : HSPC159 (78055 downstream)																							accataccactaccaccaccac	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	20	25900165	25900167	+	IGR	DEL	CAA	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr20:25900165_25900167delCAA								FAM182B (51379 upstream) : LOC100134868 (90268 downstream)																							CAGCAACCGCCAACAACTGTCCT	0.379													---	---	---							
HTR3D	200909	broad.mit.edu	37	3	183756319	183756329	+	Frame_Shift_Del	DEL	CTGCTGCTGCA	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:183756319_183756329delCTGCTGCTGCA	uc011bqv.1	+	7	1042_1052	c.1042_1052delCTGCTGCTGCA	c.(1042-1053)CTGCTGCTGCACfs	p.L348fs	HTR3D_uc003fmj.2_Frame_Shift_Del_p.L173fs|HTR3D_uc011bqu.1_Frame_Shift_Del_p.L298fs|HTR3D_uc010hxp.2_Frame_Shift_Del_p.L127fs	NM_001163646	NP_001157118	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine receptor 3 subunit D isoform	348_351	Cytoplasmic (Potential).					integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity				0	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCTCCACTCCCTGCTGCTGCACTGCACCGGC	0.649													---	---	---							
EHHADH	1962	broad.mit.edu	37	3	184910480	184910493	+	Frame_Shift_Del	DEL	CCTAATTCACAGAG	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr3:184910480_184910493delCCTAATTCACAGAG	uc003fpf.2	-	7	1720_1733	c.1693_1706delCTCTGTGAATTAGG	c.(1693-1707)CTCTGTGAATTAGGAfs	p.L565fs	EHHADH_uc011brs.1_Frame_Shift_Del_p.L469fs	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	565_569	3-hydroxyacyl-CoA dehydrogenase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	GCCAAATCGTCCTAATTCACAGAGCACATCAGGA	0.472													---	---	---							
FBXL7	23194	broad.mit.edu	37	5	15937151	15937151	+	Frame_Shift_Del	DEL	G	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr5:15937151delG	uc003jfn.1	+	4	1813	c.1332delG	c.(1330-1332)CAGfs	p.Q444fs		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	444	LRR 11.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						TCACCGGCCAGGGCTTGCAGA	0.612													---	---	---							
RAB32	10981	broad.mit.edu	37	6	146865145	146865145	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr6:146865145delC	uc003qln.1	+	1	318	c.138delC	c.(136-138)GTCfs	p.V46fs		NM_006834	NP_006825	Q13637	RAB32_HUMAN	RAB32, member RAS oncogene family	46					protein transport|small GTPase mediated signal transduction	mitochondrion	GTP binding				0		Ovarian(120;0.142)		OV - Ovarian serous cystadenocarcinoma(155;2.68e-09)|GBM - Glioblastoma multiforme(68;0.00608)		AGCGCTACGTCCACCAGCTCT	0.562													---	---	---							
ZNF735	730291	broad.mit.edu	37	7	63667602	63667603	+	Frame_Shift_Ins	INS	-	T	T			TCGA-CQ-6221-01A-11D-2078-08	TCGA-CQ-6221-10A-01D-2078-08									Somatic	Phase_I	Capture				Illumina GAIIx	d6166f0d-c0b5-44a3-814d-0c94c5bc41b0	393a336d-6a29-4e53-9285-3af63623db50	g.chr7:63667602_63667603insT	uc011kdn.1	+	1	22_23	c.22_23insT	c.(22-24)CCTfs	p.P8fs		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCGGGACCCCCTGGAAGCCGA	0.564													---	---	---							
