Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P9	11223	broad.mit.edu	37	1	17083787	17083787	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:17083787G>A	uc010ock.1	-	15	2010	c.2010C>T	c.(2008-2010)GCC>GCT	p.A670A	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Silent_p.A270A	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						GCGTGAAGACGGCTGGCCAGC	0.552000													5	33					0	0	3.86212e-05	0	0
GRIK3	2899	broad.mit.edu	37	1	37267467	37267467	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:37267467G>A	uc001caz.2	-	16	2880	c.2745C>T	c.(2743-2745)GCC>GCT	p.A915A		NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	915	Cytoplasmic (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GGAACACAGGGGCTAAGGATG	0.612000													39	13					0	0	0.000437636	0	0
STIL	6491	broad.mit.edu	37	1	47746773	47746773	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:47746773G>A	uc001crc.1	-	12	1512	c.1357C>T	c.(1357-1359)CCT>TCT	p.P453S	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.P406S|STIL_uc010omo.1_Missense_Mutation_p.P453S|STIL_uc001crd.1_Missense_Mutation_p.P453S|STIL_uc001cre.1_Missense_Mutation_p.P453S|STIL_uc001crf.1_Missense_Mutation_p.P66S|STIL_uc001crg.1_Missense_Mutation_p.P406S	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	453					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				ATCAAAGGAGGATTTTCATTA	0.428000													49	68					0	0	0.000147903	0	0
CLCA1	1179	broad.mit.edu	37	1	86959145	86959145	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:86959145G>T	uc001dlt.2	+	10	1672	c.1543G>T	c.(1543-1545)GAC>TAC	p.D515Y	CLCA1_uc001dls.1_Missense_Mutation_p.D454Y	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	chloride channel accessory 1 precursor	515					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			ovary(1)	1		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CGTGGGAAAGGACACTTTGTT	0.483000													49	9					7.06795e-37	1.61832e-35	0.000147903	1	0
FLG	2312	broad.mit.edu	37	1	152277128	152277128	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:152277128C>T	uc001ezu.1	-	3	10270	c.10234G>A	c.(10234-10236)GGA>AGA	p.G3412R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3412	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGTGGGATCCTTGTCTTCGT	0.592000									Ichthyosis				7	24					0	0	0.00010058	0	0
MUC1	4582	broad.mit.edu	37	1	155160286	155160286	+	Silent	SNP	G	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:155160286G>T	uc010pfj.1	-	4	1024	c.618C>A	c.(616-618)ACC>ACA	p.T206T	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_Silent_p.T36T|MUC1_uc001fhz.2_Silent_p.T36T|MUC1_uc010pfb.1_Silent_p.T36T|MUC1_uc010pfc.1_RNA|MUC1_uc009wph.2_Silent_p.T36T|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_RNA|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Silent_p.T36T|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Silent_p.T182T|MUC1_uc010pfi.1_Silent_p.T182T|MUC1_uc010pfk.1_RNA|MUC1_uc010pfl.1_RNA|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Silent_p.T58T|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Silent_p.T67T|MUC1_uc009wpo.2_Silent_p.T73T|MUC1_uc009wps.2_Silent_p.T94T|MUC1_uc009wpt.2_Silent_p.T97T|MUC1_uc001fic.2_Silent_p.T85T|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Silent_p.T99T|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Silent_p.T95T|MUC1_uc001fid.2_Silent_p.T86T|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Silent_p.T120T|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Silent_p.T36T|MUC1_uc001fiq.2_Silent_p.T36T|MUC1_uc009wpz.2_Silent_p.T138T|MUC1_uc010pfn.1_Silent_p.T111T|MUC1_uc009wqa.2_Silent_p.T194T|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Silent_p.T111T|MUC1_uc009wqc.2_Silent_p.T108T|MUC1_uc009wqd.2_Silent_p.T132T|MUC1_uc009wqb.2_Silent_p.T36T|MUC1_uc010pfq.1_Silent_p.T108T|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Silent_p.T36T|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Silent_p.T129T|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_RNA|MUC1_uc001fik.2_Silent_p.T129T|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Silent_p.T120T|MUC1_uc001fis.1_Intron			P15941	MUC1_HUMAN	SubName: Full=Mucin 1, cell surface associated;	1111	Extracellular (Potential).|SEA.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGACATTGATGGTACCTTCTC	0.537000			T	IGH@	B-NHL								29	5					2.12542e-12	4.76782e-11	0.000147802	1	0
TMEM79	84283	broad.mit.edu	37	1	156261374	156261374	+	Silent	SNP	C	G	G			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:156261374C>G	uc010phi.1	+	4	1366	c.1170C>G	c.(1168-1170)CCC>CCG	p.P390P	TMEM79_uc001fod.2_Silent_p.P231P|TMEM79_uc009wrw.2_Silent_p.P390P|C1orf85_uc001fof.3_Intron|C1orf85_uc001fog.1_Intron	NM_032323	NP_115699	Q9BSE2	TMM79_HUMAN	transmembrane protein 79	390						integral to membrane				central_nervous_system(1)	1	Hepatocellular(266;0.158)					ACTACAGGCCCCGCCCCTGGG	0.672000													3	52					0	0	0.00024832	0	0
NHLH1	4807	broad.mit.edu	37	1	160340839	160340839	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:160340839C>T	uc001fwa.2	+	2	760	c.318C>T	c.(316-318)CCC>CCT	p.P106P		NM_005598	NP_005589	Q02575	HEN1_HUMAN	nescient helix loop helix 1	106	Helix-loop-helix motif.				cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_cancers(52;7.11e-19)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTACGCTGCCCCCCGACAAGA	0.617000													26	27					0	0	0.000117367	0	0
RABGAP1L	9910	broad.mit.edu	37	1	174200433	174200433	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:174200433C>T	uc001gjx.2	+	4	677	c.482C>T	c.(481-483)TCC>TTC	p.S161F	RABGAP1L_uc009wwq.1_Missense_Mutation_p.S161F|RABGAP1L_uc001gjw.2_Missense_Mutation_p.S124F	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	161	PID.				regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						ATGAAATCTTCCAGTCAATAC	0.383000													109	38					0	0	0.000147903	0	0
CR2	1380	broad.mit.edu	37	1	207644140	207644140	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:207644140C>T	uc001hfw.2	+	7	1375	c.1281C>T	c.(1279-1281)GTC>GTT	p.V427V	CR2_uc001hfv.2_Silent_p.V427V|CR2_uc009xch.2_Silent_p.V427V|CR2_uc009xci.1_5'Flank	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	427	Sushi 7.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						GACACATGGTCCGCTTTGACC	0.443000													51	13					0	0	0.000147903	0	0
PCNXL2	80003	broad.mit.edu	37	1	233136157	233136157	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:233136157G>A	uc001hvl.2	-	30	5457	c.5222C>T	c.(5221-5223)TCC>TTC	p.S1741F	PCNXL2_uc001hvk.1_Missense_Mutation_p.S393F|PCNXL2_uc001hvm.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1741						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				TTCCTTGTTGGACAGCACTGC	0.607000													50	22					0	0	0.000147903	0	0
OR2T3	343173	broad.mit.edu	37	1	248637452	248637452	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:248637452G>A	uc001iel.1	+	1	801	c.801G>A	c.(799-801)CCG>CCA	p.P267P		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACATGCTCCCGAGTTCCTACC	0.547000													128	169					0	0	0.000147903	0	0
RGR	5995	broad.mit.edu	37	10	86018377	86018377	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr10:86018377G>T	uc001kdc.1	+	7	896	c.858G>T	c.(856-858)GAG>GAT	p.E286D	RGR_uc001kdd.1_Missense_Mutation_p.E290D|RGR_uc001kde.1_Missense_Mutation_p.E248D	NM_001012720	NP_001012738	P47804	RGR_HUMAN	retinal G-protein coupled receptor isoform 2	286	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity|protein binding			ovary(1)	1						AGAAGAGGGAGAAGGACCGAA	0.602000													15	6					6.31663e-08	1.38882e-06	0.000308642	1	0
MYOF	26509	broad.mit.edu	37	10	95161230	95161231	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr10:95161230_95161231GG>AA	uc001kin.2	-	12	1184_1185	c.1061_1062CC>TT	c.(1060-1062)GCC>GTT	p.A354V	MYOF_uc001kio.2_Missense_Mutation_p.A354V|MYOF_uc001kip.3_Missense_Mutation_p.A354V|MYOF_uc009xuf.2_Missense_Mutation_p.A336V	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	354	Cytoplasmic (Potential).|C2 3.				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						CCCACCGGAGGGCAATGCCAGC	0.446000													30	14					0	0	6.4e-05	0	0
DEAF1	10522	broad.mit.edu	37	11	654046	654046	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:654046G>A	uc001lqq.1	-	11	2202	c.1509C>T	c.(1507-1509)TCC>TCT	p.S503S	DEAF1_uc009ycf.1_RNA	NM_021008	NP_066288	O75398	DEAF1_HUMAN	deformed epidermal autoregulatory factor 1	503					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding				0		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		AGTTAACGCAGGACTGCTGCA	0.622000													12	14					0	0	6.40141e-05	0	0
OR51V1	283111	broad.mit.edu	37	11	5221880	5221880	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:5221880C>T	uc010qyz.1	-	1	51	c.51G>A	c.(49-51)ACG>ACA	p.T17T		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGAAGAATTCGTGCTGGTGC	0.428000													17	63					0	0	0.000422831	0	0
SLC22A10	387775	broad.mit.edu	37	11	63072194	63072194	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:63072194G>A	uc009yor.2	+	9	1639	c.1431G>A	c.(1429-1431)AGG>AGA	p.R477R	SLC22A10_uc010rmo.1_Intron|SLC22A10_uc001nwu.3_RNA|SLC22A10_uc010rmp.1_3'UTR	NM_001039752	NP_001034841	Q63ZE4	S22AA_HUMAN	solute carrier family 22, member 10	477	Helical; (Potential).					integral to membrane	transmembrane transporter activity			ovary(2)	2						CGGCTAGTAGGATTGGAGCAG	0.383000													41	67					0	0	0.000147903	0	0
SLC22A9	114571	broad.mit.edu	37	11	63138704	63138704	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:63138704C>T	uc001nww.2	+	2	768	c.500C>T	c.(499-501)TCA>TTA	p.S167L	SLC22A9_uc001nwx.2_RNA	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion/cation	167	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				breast(2)|large_intestine(1)	3						GGTCATTTATCAGACAGGTGA	0.393000													15	33					0	0	5.01169e-05	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349567	65349567	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:65349567C>T	uc001oeo.3	+	9	1689	c.1424C>T	c.(1423-1425)CCC>CTC	p.P475L	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	475										central_nervous_system(1)	1						GATGAGGCTCCCTCAGGCCTG	0.687000													15	15					0	0	0.000308642	0	0
ARAP1	116985	broad.mit.edu	37	11	72412700	72412700	+	Silent	SNP	G	T	T	rs145351119	byFrequency	TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:72412700G>T	uc001osu.2	-	16	2485	c.2296C>A	c.(2296-2298)CGG>AGG	p.R766R	ARAP1_uc001osv.2_Silent_p.R766R|ARAP1_uc001osr.2_Silent_p.R526R|ARAP1_uc001oss.2_Silent_p.R521R|ARAP1_uc009yth.2_Silent_p.R460R|ARAP1_uc010rre.1_Silent_p.R521R|ARAP1_uc001osw.1_Silent_p.R54R	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	766	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CCACCTTCCCGGGCCCGGCGG	0.637000													8	266					0.000274275	0.00576325	0.000274275	1	0
C2CD3	26005	broad.mit.edu	37	11	73748584	73748584	+	Silent	SNP	C	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:73748584C>A	uc001ouu.2	-	30	6047	c.5820G>T	c.(5818-5820)GGG>GGT	p.G1940G	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1940						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TACACTGGCTCCCAGGGTCTA	0.527000													66	103					7.75977e-34	1.76455e-32	0.000147903	1	0
P4HA3	283208	broad.mit.edu	37	11	74015355	74015355	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:74015355C>T	uc001ouz.2	-	2	346	c.303G>A	c.(301-303)AGG>AGA	p.R101R	P4HA3_uc001ouy.3_RNA|P4HA3_uc010rrj.1_Silent_p.R101R	NM_182904	NP_878907	Q7Z4N8	P4HA3_HUMAN	prolyl 4-hydroxylase, alpha III subunit	101						endoplasmic reticulum lumen	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			skin(1)	1	Breast(11;2.31e-05)					GTACCACATTCCTCCAGTCAG	0.493000													110	164					0	0	0.000147903	0	0
ODZ4	26011	broad.mit.edu	37	11	78372617	78372617	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:78372617G>A	uc001ozl.3	-	33	7891	c.7428C>T	c.(7426-7428)CTC>CTT	p.L2476L	ODZ4_uc001ozk.3_Silent_p.L701L|ODZ4_uc009yvb.1_Intron	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2476	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						ATCCAAAGGTGAGCAGCCAGC	0.507000													10	16					0	0	0.000151284	0	0
ODZ4	26011	broad.mit.edu	37	11	78380792	78380792	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:78380792C>T	uc001ozl.3	-	32	7061	c.6598G>A	c.(6598-6600)GGC>AGC	p.G2200S	ODZ4_uc001ozk.3_Missense_Mutation_p.G425S|ODZ4_uc009yvb.1_Missense_Mutation_p.G784S	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2200	Extracellular (Potential).|YD 18.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TGCAGCTGGCCGTCAGCATCA	0.542000													21	37					0	0	0.000132079	0	0
GRIA4	2893	broad.mit.edu	37	11	105774667	105774667	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:105774667C>T	uc001pix.2	+	8	1459	c.1013C>T	c.(1012-1014)CCA>CTA	p.P338L	GRIA4_uc001piu.1_Missense_Mutation_p.P338L|GRIA4_uc001piw.2_Missense_Mutation_p.P338L|GRIA4_uc009yxk.1_Missense_Mutation_p.P338L	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	338	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CCTGCTGCTCCATGGGGCCAG	0.423000													43	74					0	0	0.000106405	0	0
KDM5A	5927	broad.mit.edu	37	12	402015	402016	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:402015_402016GG>AA	uc001qif.1	-	27	5138_5139	c.4775_4776CC>TT	c.(4774-4776)CCC>CTT	p.P1592L	KDM5A_uc001qie.1_Missense_Mutation_p.P1597L	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1592					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						CATACTTTGAGGGGATGTCCAG	0.480000			T 	NUP98	AML								39	86					0	0	6.4e-05	0	0
FGF23	8074	broad.mit.edu	37	12	4488628	4488629	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:4488628_4488629GG>AA	uc001qmq.1	-	1	266_267	c.120_121CC>TT	c.(118-123)ATCCAC>ATTTAC	p.H41Y		NM_020638	NP_065689	Q9GZV9	FGF23_HUMAN	fibroblast growth factor 23 precursor	41					cell differentiation|insulin receptor signaling pathway|negative regulation of bone mineralization|negative regulation of hormone secretion|negative regulation of osteoblast differentiation|positive regulation of vitamin D 24-hydroxylase activity|regulation of phosphate transport|vitamin D catabolic process	extracellular space	growth factor activity			ovary(2)|breast(1)|skin(1)	4			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)|STAD - Stomach adenocarcinoma(119;0.206)			GTGTACAGGTGGATCAGGCCAC	0.604000													24	42					0	0	6.4e-05	0	0
MLF2	8079	broad.mit.edu	37	12	6859170	6859171	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:6859170_6859171GG>AA	uc010sfi.1	-	7	465_466	c.402_403CC>TT	c.(400-405)ATCCGG>ATTTGG	p.R135W	MLF2_uc001qqp.2_Missense_Mutation_p.R135W|MLF2_uc009zey.1_Missense_Mutation_p.R135W	NM_005439	NP_005430	Q15773	MLF2_HUMAN	myeloid leukemia factor 2	135					defense response	cytoplasm|nucleus	protein binding			large_intestine(1)	1						CGTGTCTCCCGGATCTGGGATG	0.579000													11	21					0	0	6.4e-05	0	0
CD163	9332	broad.mit.edu	37	12	7639175	7639175	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:7639175G>A	uc001qsz.3	-	10	2506	c.2378C>T	c.(2377-2379)TCC>TTC	p.S793F	CD163_uc001qta.3_Missense_Mutation_p.S793F|CD163_uc009zfw.2_Missense_Mutation_p.S826F	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	793	SRCR 7.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						CCAAATGCGGGATTCTTTTCC	0.512000													78	102					0	0	0.000147903	0	0
DENND5B	160518	broad.mit.edu	37	12	31577540	31577541	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:31577540_31577541CC>TT	uc001rki.1	-	10	2505_2506	c.2319_2320GG>AA	c.(2317-2322)GAGGAG>GAAAAG	p.E774K	DENND5B_uc001rkh.1_Missense_Mutation_p.E809K|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	774	RUN 1.					integral to membrane				ovary(1)|central_nervous_system(1)	2						AAGGTGTTCTCCTCCAGGCCGG	0.515000													61	88					0	0	6.4e-05	0	0
KIF21A	55605	broad.mit.edu	37	12	39760859	39760859	+	Silent	SNP	T	C	C			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:39760859T>C	uc001rly.2	-	5	854	c.708A>G	c.(706-708)CAA>CAG	p.Q236Q	KIF21A_uc001rlx.2_Silent_p.Q236Q|KIF21A_uc001rlz.2_Silent_p.Q236Q|KIF21A_uc010skl.1_Silent_p.Q236Q|KIF21A_uc001rma.1_Silent_p.Q244Q	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	236	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				ACACTCTGGTTTGACACACAT	0.383000													27	38					0	0	0.000339439	0	0
WNT1	7471	broad.mit.edu	37	12	49375301	49375301	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:49375301G>A	uc001rsu.2	+	4	1189	c.991G>A	c.(991-993)GGC>AGC	p.G331S		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	331					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		GCTCTGCTGCGGCAGGGGCCA	0.711000													2	0					0	0	6.4e-05	0	0
INHBC	3626	broad.mit.edu	37	12	57843480	57843480	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:57843480G>A	uc001snv.1	+	2	861	c.734G>A	c.(733-735)AGG>AAG	p.R245K		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	245					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						GGAGGGTCCAGGATGTGCTGT	0.577000													21	20					0	0	0.000175454	0	0
NAV3	89795	broad.mit.edu	37	12	78225316	78225316	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:78225316G>A	uc001syp.2	+	1	248	c.75G>A	c.(73-75)CCG>CCA	p.P25P	NAV3_uc001syo.2_Silent_p.P25P	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	25						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CTGCTCTTCCGATACCAAATC	0.463000										HNSCC(70;0.22)			52	104					0	0	0.000147903	0	0
USP44	84101	broad.mit.edu	37	12	95914926	95914926	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr12:95914926C>T	uc001teg.2	-	5	1930	c.1786G>A	c.(1786-1788)GAA>AAA	p.E596K	USP44_uc001teh.2_Missense_Mutation_p.E596K|USP44_uc009zte.2_Missense_Mutation_p.E593K	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	596					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						TTTAAGATTTCCTCAAAGCCA	0.443000													54	65					0	0	0.000147903	0	0
FAM48A	55578	broad.mit.edu	37	13	37614723	37614723	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr13:37614723G>C	uc001uwg.2	-	8	751	c.503C>G	c.(502-504)CCA>CGA	p.P168R	FAM48A_uc010abt.2_Missense_Mutation_p.P169R|FAM48A_uc001uwh.2_Missense_Mutation_p.P169R|FAM48A_uc001uwi.2_Missense_Mutation_p.P168R|FAM48A_uc001uwj.2_Missense_Mutation_p.P169R|FAM48A_uc001uwk.2_Missense_Mutation_p.P168R|FAM48A_uc010tes.1_Missense_Mutation_p.P156R|FAM48A_uc001uwl.1_Missense_Mutation_p.P168R	NM_001014286	NP_001014308	Q8NEM7	FA48A_HUMAN	family with sequence similarity 48, member A	168					autophagy|gastrulation	SAGA-type complex	protein binding				0		Lung NSC(96;2.09e-06)|Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.0959)		all cancers(112;6.06e-07)|Epithelial(112;1.87e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00794)|BRCA - Breast invasive adenocarcinoma(63;0.0128)|GBM - Glioblastoma multiforme(144;0.0477)		CTGCATTGTTGGACGTAAGAG	0.343000													3	60					0	0	6.4e-05	0	0
TDRD3	81550	broad.mit.edu	37	13	61102738	61102738	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr13:61102738C>T	uc001via.2	+	11	1888	c.1100C>T	c.(1099-1101)TCT>TTT	p.S367F	TDRD3_uc010aef.2_Missense_Mutation_p.S192F|TDRD3_uc001vhz.3_Missense_Mutation_p.S367F|TDRD3_uc010aeg.2_Missense_Mutation_p.S460F|TDRD3_uc001vib.3_Missense_Mutation_p.S366F	NM_030794	NP_110421	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3 isoform 2	367					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			upper_aerodigestive_tract(1)|skin(1)	2		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		TCTTCAGTATCTGAAGTATGG	0.373000													25	42					0	0	9.22233e-05	0	0
NPAS3	64067	broad.mit.edu	37	14	34269592	34269592	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr14:34269592C>T	uc001wru.2	+	12	2143	c.2079C>T	c.(2077-2079)TCC>TCT	p.S693S	NPAS3_uc001wrs.2_Silent_p.S680S|NPAS3_uc001wrt.2_Silent_p.S661S|NPAS3_uc001wrv.2_Silent_p.S663S	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	693					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		ACTTCCCGTCCCCGCAGGGCG	0.582000													22	26					0	0	0.000295444	0	0
SSTR1	6751	broad.mit.edu	37	14	38678811	38678811	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr14:38678811C>T	uc001wul.1	+	3	834	c.217C>T	c.(217-219)CTG>TTG	p.L73L	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	73	Helical; Name=1; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CCTGGTGGGGCTGTGTGGGAA	0.567000													18	36					0	0	7.07596e-05	0	0
SPTB	6710	broad.mit.edu	37	14	65260293	65260293	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr14:65260293G>A	uc001xht.2	-	13	2142	c.2088C>T	c.(2086-2088)ATC>ATT	p.I696I	SPTB_uc001xhr.2_Silent_p.I696I|SPTB_uc001xhs.2_Silent_p.I696I|SPTB_uc001xhu.2_Silent_p.I696I	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	696	Spectrin 4.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCTCCTGGAAGATCTGCTCCA	0.587000													15	13					0	0	0.000422831	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633363	70633363	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr14:70633363C>T	uc001xly.2	-	2	2531	c.1777G>A	c.(1777-1779)GAA>AAA	p.E593K	SLC8A3_uc001xlw.2_Missense_Mutation_p.E593K|SLC8A3_uc001xlx.2_Missense_Mutation_p.E593K|SLC8A3_uc001xlz.2_Missense_Mutation_p.E593K|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	593	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		TACACAGTTTCATCATTCTTG	0.468000													12	45					0	0	6.40141e-05	0	0
ADSSL1	122622	broad.mit.edu	37	14	105201410	105201410	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr14:105201410C>T	uc001ypd.2	+	2	320	c.246C>T	c.(244-246)TTC>TTT	p.F82F	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Silent_p.F125F|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	82					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	AGTACGACTTCCACCTGCTGC	0.612000													8	10					0	0	0.000274275	0	0
WDR90	197335	broad.mit.edu	37	16	705369	705369	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr16:705369C>T	uc002cii.1	+	15	1673	c.1619C>T	c.(1618-1620)TCC>TTC	p.S540F	WDR90_uc002cig.1_Missense_Mutation_p.S540F|WDR90_uc002cih.1_Missense_Mutation_p.S541F|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Missense_Mutation_p.S67F|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	540	WD 3.									ovary(1)	1		Hepatocellular(780;0.0218)				GTGCTGCGTTCCTGCCCCGTG	0.701000													14	15					0	0	0.000308642	0	0
UMOD	7369	broad.mit.edu	37	16	20360463	20360463	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr16:20360463C>T	uc002dgz.2	-	3	289	c.160G>A	c.(160-162)GAG>AAG	p.E54K	UMOD_uc002dha.2_Missense_Mutation_p.E54K|UMOD_uc002dhb.2_Missense_Mutation_p.E87K	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	54	EGF-like 1.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						GTGAAGCCCTCCTGACAGGTG	0.602000													10	8					0	0	6.40141e-05	0	0
TEKT3	64518	broad.mit.edu	37	17	15234335	15234335	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr17:15234335C>T	uc002gon.2	-	3	755	c.568G>A	c.(568-570)GCC>ACC	p.A190T		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	190					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		TGAAGAGGGGCTTCAGTCTCC	0.368000													15	9					0	0	5.01169e-05	0	0
FLCN	201163	broad.mit.edu	37	17	17122455	17122455	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr17:17122455G>A	uc002gra.3	-	9	1444	c.940C>T	c.(940-942)CCA>TCA	p.P314S	PLD6_uc010cpn.2_Intron	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	314					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						GTACTCTCTGGCAACACAGGG	0.562000									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				71	58					0	0	0.000147903	0	0
ACE	1636	broad.mit.edu	37	17	61568584	61568584	+	Silent	SNP	G	A	A	rs145809210	byFrequency	TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr17:61568584G>A	uc002jau.1	+	19	2776	c.2754G>A	c.(2752-2754)AGG>AGA	p.R918R	ACE_uc002jav.1_Silent_p.R344R|ACE_uc010ddv.1_Silent_p.R145R|ACE_uc010wpj.1_Silent_p.R344R|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Silent_p.R164R	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	918	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGACGCCCAGGAGGATGTTTA	0.617000													7	8					0	0	0.000157383	0	0
ZNF397OS	100101467	broad.mit.edu	37	18	32834207	32834207	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr18:32834207C>T	uc002kym.2	-	4	920	c.692G>A	c.(691-693)GGT>GAT	p.G231D	ZNF397_uc010dmq.2_Missense_Mutation_p.P190S|ZNF397_uc010dmr.2_RNA|ZNF397_uc002kyj.2_Missense_Mutation_p.P220S|ZNF397OS_uc002kyl.2_5'Flank|ZNF397OS_uc010xce.1_Missense_Mutation_p.G231D	NM_001112734	NP_001106205	Q86W11	ZSC30_HUMAN	zinc finger protein 397 opposite strand	231					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GTTGTCCAGACCTCCCAAAGC	0.463000													47	86					0	0	0.000147903	0	0
DCC	1630	broad.mit.edu	37	18	51025778	51025778	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr18:51025778C>T	uc002lfe.1	+	27	4596	c.4009C>T	c.(4009-4011)CGA>TGA	p.R1337*	DCC_uc010dpf.1_Nonsense_Mutation_p.R970*	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1337	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGCTTGTGTTCGACCAACTCA	0.532000													31	55					0	0	0.000409698	0	0
ALPK2	115701	broad.mit.edu	37	18	56204264	56204264	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr18:56204264G>A	uc002lhj.3	-	5	3369	c.3155C>T	c.(3154-3156)CCT>CTT	p.P1052L	ALPK2_uc002lhk.1_Missense_Mutation_p.P383L	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1052							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CACTTGGGAAGGAAATTGGGA	0.493000													27	55					0	0	0.000147802	0	0
CDH20	28316	broad.mit.edu	37	18	59212366	59212367	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr18:59212366_59212367GG>AA	uc010dps.1	+	9	1649_1650	c.1637_1638GG>AA	c.(1636-1638)AGG>AAA	p.R546K	CDH20_uc002lif.2_Missense_Mutation_p.R540K	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	546	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TTTACCATAAGGGACAACCAAG	0.490000													32	73					0	0	6.4e-05	0	0
SERPINB13	5275	broad.mit.edu	37	18	61262349	61262349	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr18:61262349G>A	uc002ljc.2	+	7	870	c.702G>A	c.(700-702)GGG>GGA	p.G234G	SERPINB13_uc002ljd.2_Silent_p.G98G|SERPINB13_uc010xep.1_Silent_p.G243G|SERPINB13_uc010xeq.1_Silent_p.G55G|SERPINB13_uc010xer.1_Silent_p.G55G	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	234					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						AAATTCTAGGGATTCCATATA	0.423000													39	63					0	0	0.000270559	0	0
C19orf6	91304	broad.mit.edu	37	19	1013313	1013313	+	Silent	SNP	C	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:1013313C>A	uc002lqr.1	-	3	680	c.534G>T	c.(532-534)GTG>GTT	p.V178V	C19orf6_uc002lqq.1_5'Flank|C19orf6_uc002lqs.1_Silent_p.V178V	NM_001033026	NP_001028198	Q4ZIN3	MBRL_HUMAN	membralin isoform 1	178						cytoplasm|integral to membrane				pancreas(2)|breast(1)	3		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.0252)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGCTTGAACACCTTGGGCT	0.637000													21	36					4.4004e-07	9.6114e-06	0.00047179	1	0
ZNF557	79230	broad.mit.edu	37	19	7083402	7083402	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:7083402C>T	uc002mgb.2	+	8	1404	c.919C>T	c.(919-921)CAT>TAT	p.H307Y	ZNF557_uc002mga.2_Missense_Mutation_p.H314Y|ZNF557_uc002mgc.2_Missense_Mutation_p.H314Y	NM_001044388	NP_001037853	Q8N988	ZN557_HUMAN	zinc finger protein 557 isoform b	307	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2				Lung(535;0.179)		CTATAGCATTCATACAGGGGA	0.473000													47	90					0	0	0.000147903	0	0
COL5A3	50509	broad.mit.edu	37	19	10079359	10079359	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:10079359C>T	uc002mmq.1	-	58	4284	c.4198G>A	c.(4198-4200)GGG>AGG	p.G1400R		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1400	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			ACCTTTTCCCCCTTGGGGCCA	0.577000													8	15					0	0	0.000442599	0	0
PDE4A	5141	broad.mit.edu	37	19	10574557	10574558	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:10574557_10574558CC>TT	uc002moj.2	+	14	1940_1941	c.1832_1833CC>TT	c.(1831-1833)GCC>GTT	p.A611V	PDE4A_uc002mok.2_Missense_Mutation_p.A585V|PDE4A_uc002mol.2_Missense_Mutation_p.A550V|PDE4A_uc002mom.2_Missense_Mutation_p.A372V|PDE4A_uc002mon.2_Missense_Mutation_p.A66V|PDE4A_uc002moo.2_Missense_Mutation_p.A277V	NM_001111307	NP_001104777	P27815	PDE4A_HUMAN	phosphodiesterase 4A isoform 1	611	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CGCATCATGGCCGAGTTCTTCC	0.614000													21	32					0	0	6.4e-05	0	0
DNM2	1785	broad.mit.edu	37	19	10940994	10940994	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:10940994C>T	uc002mps.1	+	20	2647	c.2483C>T	c.(2482-2484)CCG>CTG	p.P828L	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.P828L|DNM2_uc002mpv.1_Missense_Mutation_p.P824L|DNM2_uc002mpu.1_Missense_Mutation_p.P824L|DNM2_uc010dxl.1_Missense_Mutation_p.P828L|DNM2_uc002mpw.2_Missense_Mutation_p.P557L|DNM2_uc002mpx.1_Missense_Mutation_p.P184L	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	828	Pro-rich.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			TTCCCAGCCCCGCCTCAGATC	0.677000													30	27					0	0	0.000279167	0	0
DNM2	1785	broad.mit.edu	37	19	10941011	10941011	+	Silent	SNP	C	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:10941011C>A	uc002mps.1	+	20	2664	c.2500C>A	c.(2500-2502)CGG>AGG	p.R834R	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Silent_p.R834R|DNM2_uc002mpv.1_Silent_p.R830R|DNM2_uc002mpu.1_Silent_p.R830R|DNM2_uc010dxl.1_Silent_p.R834R|DNM2_uc002mpw.2_Silent_p.R563R|DNM2_uc002mpx.1_Silent_p.R190R	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	834	Pro-rich.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GATCCCATCTCGGCCAGTTCG	0.672000													23	21					1.96895e-08	4.35794e-07	0.000375601	1	0
NFIX	4784	broad.mit.edu	37	19	13184813	13184814	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:13184813_13184814GG>AA	uc010xmx.1	+	5	868_869	c.815_816GG>AA	c.(814-816)CGG>CAA	p.R272Q	NFIX_uc002mwd.2_Missense_Mutation_p.R264Q|NFIX_uc002mwe.2_Missense_Mutation_p.R256Q|NFIX_uc002mwf.2_Missense_Mutation_p.R267Q|NFIX_uc002mwg.1_Missense_Mutation_p.R263Q			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	264					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			CTGGGGCGGCGGTCCATCACCT	0.624000													23	46					0	0	6.4e-05	0	0
NACC1	112939	broad.mit.edu	37	19	13247126	13247126	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:13247126C>T	uc002mwm.2	+	3	1195	c.1027C>T	c.(1027-1029)CTC>TTC	p.L343F		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	343					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						CCTGGCGTCTCTCCCGGCTGA	0.647000													17	45					0	0	9.7654e-05	0	0
ZNF681	148213	broad.mit.edu	37	19	23927190	23927190	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:23927190G>A	uc002nrk.3	-	4	1304	c.1162C>T	c.(1162-1164)CAT>TAT	p.H388Y	ZNF681_uc002nrl.3_Missense_Mutation_p.H319Y|ZNF681_uc002nrj.3_Missense_Mutation_p.H319Y	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	388	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TCTCCAGTATGAATTATCTTA	0.398000													15	27					0	0	0.000308642	0	0
FFAR3	2865	broad.mit.edu	37	19	35850670	35850670	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:35850670G>A	uc002nzd.2	+	2	953	c.878G>A	c.(877-879)AGG>AAG	p.R293K	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	293	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			CTGCTGAGGAGGTTGTGTGGG	0.592000													6	37					0	0	0.000279167	0	0
IRGC	56269	broad.mit.edu	37	19	44223374	44223374	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:44223374C>T	uc002oxh.2	+	2	811	c.664C>T	c.(664-666)CGC>TGC	p.R222C		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	222						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CTCGCCGGCCCGCTACGACTT	0.701000													13	15					0	0	0.000151284	0	0
RAB1A	5861	broad.mit.edu	37	2	65315800	65315800	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:65315800G>A	uc002sdm.2	-	6	831	c.445C>T	c.(445-447)CCG>TCG	p.P149S	RAB1A_uc002sdn.2_Missense_Mutation_p.P73S|RAB1A_uc010yqe.1_Missense_Mutation_p.P117S|RAB1A_uc002sdo.2_Missense_Mutation_p.P85S	NM_004161	NP_004152	P62820	RAB1A_HUMAN	RAB1A, member RAS oncogene family isoform 1	149					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum|Golgi apparatus	GTP binding|GTPase activity				0						TCCAAAAACGGAATTCCAAGG	0.393000													5	10					0	0	1.23904e-05	0	0
NPAS2	4862	broad.mit.edu	37	2	101598697	101598697	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:101598697C>T	uc002tap.1	+	16	1773	c.1487C>T	c.(1486-1488)TCG>TTG	p.S496L	NPAS2_uc010yvt.1_Missense_Mutation_p.S561L|NPAS2_uc010fit.1_Missense_Mutation_p.S74L	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	496					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						TTGAAGTTTTCGGCACAGTTC	0.507000													8	10					0	0	0.000274275	0	0
CFC1B	653275	broad.mit.edu	37	2	131356273	131356273	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:131356273C>T	uc002tro.1	-	3	580	c.189G>A	c.(187-189)GGG>GGA	p.G63G		NM_001079530	NP_001072998	P0CG36	CFC1B_HUMAN	cripto, FRL-1, cryptic family 1B	63					gastrulation	extracellular region					0	Colorectal(110;0.1)					CCTCGGCGCTCCCAGTCACCT	0.617000													13	55					0	0	7.07596e-05	0	0
ARL5A	26225	broad.mit.edu	37	2	152670746	152670746	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:152670746C>G	uc002txx.1	-	3	511	c.192G>C	c.(190-192)ATG>ATC	p.M64I	ARL5A_uc010zcc.1_RNA|ARL5A_uc002txv.1_Missense_Mutation_p.M27I|ARL5A_uc002txw.1_Missense_Mutation_p.M27I	NM_012097	NP_036229	Q9Y689	ARL5A_HUMAN	ADP-ribosylation factor-like 5A isoform 1	64					small GTPase mediated signal transduction	intracellular	GTP binding				0				BRCA - Breast invasive adenocarcinoma(221;0.153)		CAATATCCCACATTAGGAAAC	0.328000													9	148					0	0	0.000274275	0	0
SCN2A	6326	broad.mit.edu	37	2	166231233	166231233	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:166231233C>T	uc002udc.2	+	22	4301	c.4011C>T	c.(4009-4011)ATC>ATT	p.I1337I	SCN2A_uc002udd.2_Silent_p.I1337I|SCN2A_uc002ude.2_Silent_p.I1337I	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1337	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TTCCATCTATCATGAATGTAC	0.343000													31	73					0	0	0.000409698	0	0
TTN	7273	broad.mit.edu	37	2	179632581	179632581	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:179632581T>C	uc010zfg.1	-	40	9600	c.9376A>G	c.(9376-9378)AAG>GAG	p.K3126E	TTN_uc010zfh.1_Missense_Mutation_p.K3080E|TTN_uc010zfi.1_Missense_Mutation_p.K3080E|TTN_uc010zfj.1_Missense_Mutation_p.K3080E|TTN_uc002unb.2_Missense_Mutation_p.K3126E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3126							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTGTGTACTTCCCAGCATCA	0.448000													27	42					0	0	9.22233e-05	0	0
ZNF385B	151126	broad.mit.edu	37	2	180348096	180348096	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:180348096C>T	uc002unn.3	-	6	1177	c.573G>A	c.(571-573)ACG>ACA	p.T191T	ZNF385B_uc002unj.2_Silent_p.T89T|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.T88T|ZNF385B_uc002unm.2_Silent_p.T115T	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	191						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			GTTTATTTTTCGTTGCGTCTA	0.468000													19	30					0	0	0.000132079	0	0
STAT4	6775	broad.mit.edu	37	2	191894583	191894583	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:191894583G>A	uc002usm.1	-	24	2484	c.2230C>T	c.(2230-2232)CCT>TCT	p.P744S	STAT4_uc002usn.1_Missense_Mutation_p.P744S	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	744					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GCAGAATAAGGAGACTTCATC	0.323000													52	127					0	0	0.000147903	0	0
STAT4	6775	broad.mit.edu	37	2	191903927	191903927	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:191903927G>T	uc002usm.1	-	16	1686	c.1432C>A	c.(1432-1434)CAG>AAG	p.Q478K	STAT4_uc002usn.1_Missense_Mutation_p.Q478K|STAT4_uc010zgk.1_Missense_Mutation_p.Q323K|STAT4_uc002uso.2_Missense_Mutation_p.Q478K	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	478					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GAGTCTACCTGGGAATCGTTG	0.433000													7	79					0.000157383	0.00334944	0.000157383	1	0
PRKAG3	53632	broad.mit.edu	37	2	219694899	219694899	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:219694899C>T	uc002vjb.1	-	4	454	c.435G>A	c.(433-435)TGG>TGA	p.W145*	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Nonsense_Mutation_p.W145*|PRKAG3_uc010zko.1_Nonsense_Mutation_p.W141*	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	145					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTCACACTCCCAGGCCTCTG	0.637000													14	21					0	0	0.000151284	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882591	228882591	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:228882591C>T	uc002vpq.2	-	7	3026	c.2979G>A	c.(2977-2979)AGG>AGA	p.R993R	SPHKAP_uc002vpp.2_Silent_p.R993R|SPHKAP_uc010zlx.1_Silent_p.R993R	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	993						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTTGTGTTTCCTCACAGCGG	0.537000													24	46					0	0	9.22233e-05	0	0
DIS3L2	129563	broad.mit.edu	37	2	233194675	233194676	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:233194675_233194676CC>TT	uc010fxz.2	+	15	2168_2169	c.1892_1893CC>TT	c.(1891-1893)CCC>CTT	p.P631L	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	631							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		ATGGGGCTGCCCGTGGACTTCA	0.653000													24	34					0	0	6.4e-05	0	0
HJURP	55355	broad.mit.edu	37	2	234749971	234749971	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr2:234749971C>T	uc002vvg.2	-	8	1521	c.1455G>A	c.(1453-1455)CTG>CTA	p.L485L	HJURP_uc010znd.1_Silent_p.L424L|HJURP_uc010zne.1_Silent_p.L393L	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	485					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		AAGGTAAACTCAGCCTGCGGG	0.547000													26	41					0	0	0.000117367	0	0
ATRN	8455	broad.mit.edu	37	20	3578567	3578567	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr20:3578567G>A	uc002wim.2	+	22	3574	c.3484G>A	c.(3484-3486)GAC>AAC	p.D1162N	ATRN_uc002wil.2_Missense_Mutation_p.D1162N	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	1162	Extracellular (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TCTTCTTATTGACTATCAGTT	0.333000													74	111					0	0	0.000147903	0	0
C21orf99	149992	broad.mit.edu	37	21	14414855	14414855	+	RNA	SNP	A	G	G	rs141732548	by1000genomes	TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr21:14414855A>G	uc002yiy.3	+	2		c.292A>G			C21orf99_uc002yja.3_RNA					Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						GCCAATGGCCATGCAGAAGTA	0.448000													4	51					0	0	3.59834e-05	0	0
C21orf99	149992	broad.mit.edu	37	21	14439174	14439174	+	RNA	SNP	T	C	C			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr21:14439174T>C	uc002yja.3	+	10		c.2692T>C				NR_026916				Homo sapiens C21orf99 protein (C21orf99) mRNA, complete cds.												0						TAATGGCAGATTGACTTTAAA	0.269000													26	47					0	0	0.000227799	0	0
C21orf63	59271	broad.mit.edu	37	21	33887456	33887456	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr21:33887456G>T	uc002ypr.1	+	8	1692	c.1282G>T	c.(1282-1284)GGT>TGT	p.G428C	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.G425C|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.G333C|C21orf63_uc011adq.1_3'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	428	Cytoplasmic (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						GATGAACAGTGGTTTGGACAC	0.458000													7	123					7.48243e-07	1.62364e-05	0.000442599	1	0
KCNJ6	3763	broad.mit.edu	37	21	39212975	39212975	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr21:39212975G>A	uc011aej.1	-	2	63	c.10C>T	c.(10-12)CTG>TTG	p.L4L	KCNJ6_uc002ywo.2_Silent_p.L4L	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	4	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	GATTCTGTCAGCTTGGCCATT	0.338000													193	325					0	0	0.000147903	0	0
DSCR10	259234	broad.mit.edu	37	21	39580475	39580475	+	RNA	SNP	C	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr21:39580475C>A	uc010gnt.1	+	3		c.597C>A				NR_027695				Homo sapiens DSCR10 mRNA, complete cds.												0						AGCCATGCTCCCGTGTCACTG	0.522000													14	275					0.000151284	0.00326146	0.000151284	1	0
AIFM3	150209	broad.mit.edu	37	22	21331325	21331325	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr22:21331325A>T	uc002ztj.2	+	14	1441	c.1223A>T	c.(1222-1224)AAG>ATG	p.K408M	AIFM3_uc002ztk.2_Missense_Mutation_p.K408M|AIFM3_uc002ztl.2_Missense_Mutation_p.K414M|AIFM3_uc011ahx.1_Missense_Mutation_p.K396M|AIFM3_uc002ztm.1_Missense_Mutation_p.K220M|LZTR1_uc002ztn.2_5'Flank	NM_144704	NP_653305	Q96NN9	AIFM3_HUMAN	apoptosis-inducing factor,	408					activation of caspase activity by cytochrome c|cell redox homeostasis|electron transport chain|induction of apoptosis|mitochondrial depolarization|transport	endoplasmic reticulum|mitochondrial inner membrane	2 iron, 2 sulfur cluster binding|caspase activator activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity|protein binding			ovary(2)|lung(2)	4	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CCACAGCTGAAGGAGGTTGTG	0.617000													22	27					0	0	0.00047179	0	0
SEC14L4	284904	broad.mit.edu	37	22	30886142	30886142	+	Silent	SNP	C	T	T	rs146895070	byFrequency	TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr22:30886142C>T	uc003aid.2	-	12	1273	c.1173G>A	c.(1171-1173)GAG>GAA	p.E391E	SEC14L4_uc011akz.1_Intron|SEC14L4_uc003aie.2_Silent_p.E376E|SEC14L4_uc003aif.2_Missense_Mutation_p.R352K	NM_174977	NP_777637	Q9UDX3	S14L4_HUMAN	SEC14p-like protein TAP3 isoform a	391						integral to membrane|intracellular	lipid binding|transporter activity			skin(1)	1					Vitamin E(DB00163)	GCAGCGTCTCCTCAGAGGCCT	0.592000													16	34					0	0	9.7654e-05	0	0
OSBPL10	114884	broad.mit.edu	37	3	31710306	31710306	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:31710306C>T	uc003cev.2	-	11	2305	c.1924G>A	c.(1924-1926)GAA>AAA	p.E642K	OSBPL10_uc003ceu.1_Missense_Mutation_p.E399K|OSBPL10_uc011axf.1_Missense_Mutation_p.E578K	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	642					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		TGCTTCACTTCTGCGGTAACC	0.378000													6	113					0	0	8.12818e-05	0	0
SCN5A	6331	broad.mit.edu	37	3	38645368	38645368	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:38645368C>T	uc003cio.2	-	12	1919	c.1725G>A	c.(1723-1725)CAG>CAA	p.Q575Q	SCN5A_uc003cin.2_Silent_p.Q575Q|SCN5A_uc003cil.3_Silent_p.Q575Q|SCN5A_uc010hhi.2_Silent_p.Q575Q|SCN5A_uc010hhk.2_Silent_p.Q575Q|SCN5A_uc011ayr.1_Silent_p.Q575Q|SCN5A_uc010hhj.1_Silent_p.Q186Q	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	575					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CGGGACTGGGCTGTCCCTGGG	0.627000													33	74					0	0	0.000228196	0	0
STAB1	23166	broad.mit.edu	37	3	52551984	52551984	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:52551984G>A	uc003dej.2	+	45	4800	c.4726G>A	c.(4726-4728)GGG>AGG	p.G1576R	STAB1_uc003dek.1_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1576	Extracellular (Potential).|EGF-like 13.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCACACCGTGGGGGACGGCCT	0.617000													25	22					0	0	0.000227799	0	0
CLRN1	7401	broad.mit.edu	37	3	150659495	150659495	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:150659495G>A	uc003eyk.1	-	2	598	c.307C>T	c.(307-309)CTC>TTC	p.L103F	CLRN1OS_uc011bny.1_Intron|CLRN1_uc003eyj.2_Missense_Mutation_p.L27F|CLRN1_uc010hvj.1_RNA	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	103	Helical; (Potential).				equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GCAGAGAAGAGAATGACATTG	0.418000													16	9					0	0	0.000422831	0	0
HRG	3273	broad.mit.edu	37	3	186390628	186390628	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:186390628C>T	uc003fqq.2	+	5	634	c.611C>T	c.(610-612)CCC>CTC	p.P204L		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	204	Cystatin 2.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CGGAACTGCCCCAGACACCAT	0.393000													30	20					0	0	0.000491102	0	0
TP63	8626	broad.mit.edu	37	3	189526072	189526072	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:189526072G>A	uc003fry.2	+	4	425	c.336G>A	c.(334-336)ACG>ACA	p.T112T	TP63_uc003frx.2_Silent_p.T112T|TP63_uc003frz.2_Silent_p.T112T|TP63_uc010hzc.1_Silent_p.T112T|TP63_uc003fsa.2_Silent_p.T18T|TP63_uc003fsb.2_Silent_p.T18T|TP63_uc003fsc.2_Silent_p.T18T|TP63_uc003fsd.2_Silent_p.T18T|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_5'UTR	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	112					anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CACAGTACACGAACCTGGGGC	0.547000									Hay-Wells_syndrome	HNSCC(45;0.13)			22	14					0	0	9.22233e-05	0	0
HRASLS	57110	broad.mit.edu	37	3	192980846	192980846	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:192980846G>A	uc003fta.2	+	3	632	c.227G>A	c.(226-228)GGA>GAA	p.G76E		NM_020386	NP_065119	Q9HDD0	HRSL1_HUMAN	HRAS-like suppressor	76											0	all_cancers(143;9.1e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000159)		GATGTTGTGGGAAATGACACA	0.433000													56	33					0	0	0.000147903	0	0
SEL1L3	23231	broad.mit.edu	37	4	25835070	25835070	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr4:25835070C>T	uc003gru.3	-	4	1134	c.982G>A	c.(982-984)GGC>AGC	p.G328S		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	328						integral to membrane	binding				0						TTATACTCACCCTCTTCCGTA	0.373000													10	34					0	0	0.00010058	0	0
PROL1	58503	broad.mit.edu	37	4	71275483	71275483	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr4:71275483C>T	uc003hfi.2	+	3	612	c.438C>T	c.(436-438)ATC>ATT	p.I146I		NM_021225	NP_067048	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	146					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			large_intestine(1)	1		all_hematologic(202;0.196)				AAATAAACATCACCACCGCAG	0.448000													17	42					0	0	5.01169e-05	0	0
PCDH10	57575	broad.mit.edu	37	4	134072765	134072765	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr4:134072765G>A	uc003iha.2	+	1	2296	c.1470G>A	c.(1468-1470)CGG>CGA	p.R490R	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.R490R	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	490	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CCACCGACCGGGATGAGGGCG	0.592000													25	44					0	0	0.00047179	0	0
WWC2	80014	broad.mit.edu	37	4	184210777	184210777	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr4:184210777G>A	uc010irx.2	+	21	3555	c.3373G>A	c.(3373-3375)GCT>ACT	p.A1125T	WWC2_uc003ivk.3_Missense_Mutation_p.A920T|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.A807T|WWC2_uc003ivn.3_Missense_Mutation_p.A640T|WWC2_uc010irz.2_Missense_Mutation_p.A466T|WWC2_uc003ivo.3_Missense_Mutation_p.A253T	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1125	Potential.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TCTGAAGCAAGCTGAGAAGCA	0.527000													17	43					0	0	0.000175454	0	0
DNAH5	1767	broad.mit.edu	37	5	13716799	13716799	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr5:13716799C>T	uc003jfd.2	-	74	12748	c.12706G>A	c.(12706-12708)GGT>AGT	p.G4236S	DNAH5_uc003jfc.2_Missense_Mutation_p.G404S	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4236					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAGGAGACACCCTGGGAAATT	0.398000									Kartagener_syndrome				22	17					0	0	7.16444e-05	0	0
SPEF2	79925	broad.mit.edu	37	5	35793345	35793345	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr5:35793345C>T	uc003jjo.2	+	32	4750	c.4639C>T	c.(4639-4641)CCC>TCC	p.P1547S	SPEF2_uc003jjp.1_Missense_Mutation_p.P1033S|SPEF2_uc003jjr.2_Missense_Mutation_p.P602S	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1547					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AATGCCTTGGCCCATTCCCTT	0.468000													30	59					0	0	0.000279167	0	0
CARTPT	9607	broad.mit.edu	37	5	71016376	71016376	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr5:71016376G>A	uc003kbv.1	+	3	412	c.285G>A	c.(283-285)AGG>AGA	p.R95R		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	95					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	AAGGGGCAAGGATCGGGAAGC	0.532000													6	18					0	0	3.59834e-05	0	0
FBN2	2201	broad.mit.edu	37	5	127666379	127666379	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr5:127666379C>T	uc003kuu.2	-	33	4670	c.4231G>A	c.(4231-4233)GAA>AAA	p.E1411K	FBN2_uc003kuv.2_Missense_Mutation_p.E1378K	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1411	EGF-like 23; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTAGAACATTCGTCCAGATCT	0.428000													13	21					0	0	0.000308642	0	0
LMAN2	10960	broad.mit.edu	37	5	176759165	176759165	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr5:176759165G>A	uc003mge.2	-	8	1230	c.993C>T	c.(991-993)CTC>CTT	p.L331L	LMAN2_uc003mgd.2_3'UTR	NM_006816	NP_006807	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2 precursor	331	Helical; (Potential).				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding				0	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGATGCCCAGGAGAGCGCACA	0.687000													16	16					0	0	9.7654e-05	0	0
FAM193B	54540	broad.mit.edu	37	5	176951979	176951979	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr5:176951979G>A	uc003mhs.3	-	8	2993	c.1404C>T	c.(1402-1404)GGC>GGT	p.G468G	FAM193B_uc003mhr.2_Silent_p.G5G|FAM193B_uc003mht.2_Silent_p.G127G|FAM193B_uc003mhu.2_Silent_p.G180G|FAM193B_uc003mhv.2_Silent_p.G127G|FAM193B_uc003mhw.2_RNA	NM_019057	NP_061930	E9PET5	E9PET5_HUMAN	hypothetical protein LOC54540	501											0						CCTTAGAGAAGCCATTGCTGT	0.557000													16	29					0	0	5.01169e-05	0	0
EHMT2	10919	broad.mit.edu	37	6	31848861	31848862	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:31848861_31848862CC>AA	uc003nxz.1	-	26	3215_3216	c.3205_3206GG>TT	c.(3205-3207)GGG>TTG	p.G1069L	EHMT2_uc003nxv.1_Missense_Mutation_p.G108L|EHMT2_uc003nxw.1_Missense_Mutation_p.G108L|EHMT2_uc003nxx.1_Missense_Mutation_p.G267L|EHMT2_uc003nxy.1_Missense_Mutation_p.G867L|EHMT2_uc011don.1_Missense_Mutation_p.G1092L|EHMT2_uc003nya.1_Missense_Mutation_p.G1035L|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1069	SET.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GATCAGCTCCCCGACATACCTG	0.535000													9	246					0	0	6.4e-05	0	0
PPT2	9374	broad.mit.edu	37	6	32122816	32122816	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:32122816G>T	uc003nzx.2	+	3	761	c.193G>T	c.(193-195)GGG>TGG	p.G65W	PRRT1_uc003nzu.2_5'Flank|uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Missense_Mutation_p.G71W|PPT2_uc011dpi.1_Intron|PPT2_uc003nzy.1_RNA|PPT2_uc003nzz.2_Missense_Mutation_p.G65W|PPT2_uc003oaa.2_Missense_Mutation_p.G65W|PPT2_uc010jtu.1_Missense_Mutation_p.G65W	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a	65					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						GACACACCCCGGGACTGTGGT	0.622000													8	177					0.000157383	0.00334944	0.000157383	1	0
FGD2	221472	broad.mit.edu	37	6	36995237	36995237	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:36995237G>A	uc010jwp.1	+	15	1809	c.1638G>A	c.(1636-1638)CTG>CTA	p.L546L	FGD2_uc003ong.2_Silent_p.L268L|FGD2_uc011dtv.1_Silent_p.L174L|FGD2_uc003onj.1_Silent_p.L123L	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	546	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						ACCAGAGCCTGATGTGCAGCT	0.547000													47	75					0	0	0.000147903	0	0
SLC22A7	10864	broad.mit.edu	37	6	43270055	43270055	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:43270055C>T	uc003out.2	+	8	1278	c.1179C>T	c.(1177-1179)GTC>GTT	p.V393V	SLC22A7_uc010jyl.1_Silent_p.V394V|SLC22A7_uc003ous.2_Silent_p.V391V	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	393	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			AGCTGCTGGTCTACTTGTCGG	0.632000													8	10					0	0	0.000274275	0	0
COL19A1	1310	broad.mit.edu	37	6	70894614	70894614	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:70894614G>A	uc003pfc.1	+	45	2912	c.2795G>A	c.(2794-2796)GGA>GAA	p.G932E		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	932	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GGAAAAGATGGAATACCAGGT	0.313000													35	58					0	0	0.000109025	0	0
C6orf165	154313	broad.mit.edu	37	6	88173915	88173915	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:88173915G>A	uc003plv.2	+	13	1908	c.1816G>A	c.(1816-1818)GAA>AAA	p.E606K	SLC35A1_uc003plx.2_RNA|C6orf165_uc003plw.2_Missense_Mutation_p.E418K|C6orf165_uc010kbv.1_RNA	NM_001031743	NP_001026913	Q8IYR0	CF165_HUMAN	hypothetical protein LOC154313 isoform 1	606										central_nervous_system(1)	1		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGGAAAGAGCGAAATCACCGA	0.458000													17	19					0	0	5.01169e-05	0	0
BACH2	60468	broad.mit.edu	37	6	90642327	90642327	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:90642327G>A	uc011eab.1	-	9	3135	c.2326C>T	c.(2326-2328)CCC>TCC	p.P776S	BACH2_uc003pnw.2_Missense_Mutation_p.P776S	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	776						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GGTCCGGGGGGAGCCGCGCCT	0.632000													25	36					0	0	7.16444e-05	0	0
RFX6	222546	broad.mit.edu	37	6	117198636	117198636	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:117198636G>A	uc003pxm.2	+	1	261	c.198G>A	c.(196-198)CCG>CCA	p.P66P		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	66					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GCGAAGACCCGGAGCTGCCGG	0.617000													4	5					0	0	0.00024832	0	0
LAMA2	3908	broad.mit.edu	37	6	129609164	129609164	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:129609164G>A	uc003qbn.2	+	19	2815	c.2710G>A	c.(2710-2712)GGA>AGA	p.G904R	LAMA2_uc003qbo.2_Missense_Mutation_p.G904R	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	904	Laminin EGF-like 8.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGTGCTGATGGATATTTTGG	0.478000													66	96					0	0	0.000147903	0	0
EPB41L2	2037	broad.mit.edu	37	6	131201339	131201339	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:131201339G>A	uc003qch.2	-	13	2023	c.1841C>T	c.(1840-1842)TCC>TTC	p.S614F	EPB41L2_uc003qce.1_Intron|EPB41L2_uc003qcf.1_RNA|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Intron|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Intron|EPB41L2_uc003qcj.1_5'Flank	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	614	Spectrin--actin-binding.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TACTCTCAAGGAATTTTTCTG	0.383000													5	17					0	0	1.23904e-05	0	0
IPCEF1	26034	broad.mit.edu	37	6	154544362	154544362	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:154544362C>T	uc003qpx.2	-	6	415	c.259G>A	c.(259-261)GGA>AGA	p.G87R	OPRM1_uc003qpt.1_Intron|IPCEF1_uc003qpw.2_Missense_Mutation_p.G88R|IPCEF1_uc010kjh.2_Missense_Mutation_p.G88R	NM_015553	NP_056368	Q8WWN9	ICEF1_HUMAN	phosphoinositide-binding protein PIP3-E isoform	87	PH.				response to oxidative stress	cytoplasm|plasma membrane	oxygen transporter activity|peroxidase activity				0						TTGACAAATCCATCAGCTTTC	0.398000													5	27					0	0	8.12818e-05	0	0
TIAM2	26230	broad.mit.edu	37	6	155469378	155469378	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:155469378G>A	uc003qqb.2	+	9	3211	c.1938G>A	c.(1936-1938)AAG>AAA	p.K646K	TIAM2_uc003qqe.2_Silent_p.K646K|TIAM2_uc010kjj.2_Silent_p.K179K|TIAM2_uc003qqf.2_5'UTR|TIAM2_uc011efl.1_5'Flank|TIAM2_uc003qqg.2_5'Flank	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	646	Potential.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		TGCTTCAGAAGATAGACATGG	0.502000													19	25					0	0	0.000132079	0	0
OSTCL	202459	broad.mit.edu	37	6	159262893	159262893	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:159262893G>A	uc003qrw.2	-	3	451	c.220C>T	c.(220-222)CTG>TTG	p.L74L		NM_145303	NP_660346			oligosaccharyltransferase complex subunit-like												0						CATCGGTCCAGGAATATGAAA	0.393000													34	64					0	0	0.000109025	0	0
THBS2	7058	broad.mit.edu	37	6	169637839	169637839	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr6:169637839G>A	uc003qwt.2	-	9	1429	c.1181C>T	c.(1180-1182)TCC>TTC	p.S394F		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	394	TSP type-1 1.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		ACACGTCACGGAGCACTGGGT	0.652000													13	16					0	0	0.000308642	0	0
CCDC129	223075	broad.mit.edu	37	7	31682949	31682949	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:31682949C>G	uc003tcj.1	+	11	2958	c.1965C>G	c.(1963-1965)GAC>GAG	p.D655E	CCDC129_uc011kad.1_Missense_Mutation_p.D665E|CCDC129_uc003tci.1_Missense_Mutation_p.D506E|CCDC129_uc011kae.1_Missense_Mutation_p.D681E|CCDC129_uc003tck.1_Missense_Mutation_p.D563E	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	655											0						ATGCAACTGACCTTGCTCAAA	0.488000													40	40					0	0	0.000125731	0	0
SEMA3E	9723	broad.mit.edu	37	7	83032082	83032082	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:83032082G>A	uc003uhy.1	-	10	1475	c.1009C>T	c.(1009-1011)CGA>TGA	p.R337*		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	337	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				GCATGCCCTCGAAAAATATTA	0.403000													24	27					0	0	0.000375601	0	0
LAMB4	22798	broad.mit.edu	37	7	107738881	107738881	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:107738881C>T	uc010ljo.1	-	11	1411	c.1327G>A	c.(1327-1329)GGA>AGA	p.G443R	LAMB4_uc003vey.2_Missense_Mutation_p.G443R	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	443	Laminin EGF-like 3.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						GCGCTTAGTCCGTAGTGGTTG	0.577000													27	54					0	0	0.000491102	0	0
SPAM1	6677	broad.mit.edu	37	7	123594215	123594215	+	Silent	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:123594215G>A	uc003vld.2	+	4	993	c.591G>A	c.(589-591)AAG>AAA	p.K197K	SPAM1_uc003vle.2_Silent_p.K197K|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Silent_p.K197K|SPAM1_uc010lku.2_Silent_p.K197K	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	197					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AGGCAGGGAAGGATTTCCTGG	0.373000													26	73					0	0	0.000147802	0	0
TNPO3	23534	broad.mit.edu	37	7	128615931	128615931	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:128615931A>C	uc003vol.1	-	17	2494	c.2120T>G	c.(2119-2121)CTT>CGT	p.L707R	TNPO3_uc010llx.1_Missense_Mutation_p.L118R|TNPO3_uc003vom.1_Missense_Mutation_p.L641R|TNPO3_uc010lly.1_Missense_Mutation_p.L741R|TNPO3_uc010llz.1_Missense_Mutation_p.L643R	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	707					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TTCATCCACAAGGATACTGCC	0.478000													22	26					0	0	0.000229342	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				45	48					0	0	0.000147903	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881273	142881273	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:142881273G>A	uc011ksw.1	+	1	762	c.762G>A	c.(760-762)ATG>ATA	p.M254I		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	254	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					ACCCCAGCATGGAGGCTCACA	0.488000													31	113					0	0	0.000191422	0	0
CLCN1	1180	broad.mit.edu	37	7	143047514	143047514	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:143047514C>T	uc003wcr.1	+	21	2540	c.2453C>T	c.(2452-2454)TCC>TTC	p.S818F	CLCN1_uc011ktc.1_Missense_Mutation_p.S430F	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	818	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TGTTTTGATTCCTGCTGTATT	0.557000													24	18					0	0	0.000147802	0	0
OR2A12	346525	broad.mit.edu	37	7	143793006	143793006	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr7:143793006G>A	uc011kty.1	+	1	806	c.806G>A	c.(805-807)CGG>CAG	p.R269Q		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TCTCAAGAACGGAGGAAGATC	0.527000													94	218					0	0	0.000147903	0	0
SLC18A1	6570	broad.mit.edu	37	8	20004873	20004873	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr8:20004873C>T	uc011kyq.1	-	16	1831	c.1360G>A	c.(1360-1362)GCC>ACC	p.A454T	SLC18A1_uc003wzl.2_Missense_Mutation_p.A241T|SLC18A1_uc003wzm.2_Missense_Mutation_p.A454T|SLC18A1_uc011kyr.1_Intron|SLC18A1_uc003wzn.2_Missense_Mutation_p.A422T|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Missense_Mutation_p.A422T	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	454	Helical; (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		AAACCGATGGCCTTTACAATG	0.537000													18	12					0	0	0.000229342	0	0
ADCY8	114	broad.mit.edu	37	8	131859680	131859680	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr8:131859680G>A	uc003ytd.3	-	11	2748	c.2492C>T	c.(2491-2493)TCC>TTC	p.S831F	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	831	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTCTGGGTAGGAGCAGATATC	0.413000										HNSCC(32;0.087)			26	50					0	0	0.000147802	0	0
SPAG8	26206	broad.mit.edu	37	9	35811380	35811380	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr9:35811380C>T	uc003zye.2	-	2	778	c.663G>A	c.(661-663)GTG>GTA	p.V221V	SPAG8_uc003zyf.2_Silent_p.V138V|SPAG8_uc003zyg.2_Silent_p.V221V	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	221						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			CCCGATCTGCCACCAGGTTTC	0.547000													88	32					0	0	0.000147903	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962602	41962602	+	RNA	SNP	G	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr9:41962602G>T	uc004aca.3	-	3		c.907C>A				NR_003670				Homo sapiens cDNA FLJ76381 complete cds.												0						TTCTTTCTTTGTTTTTTTTCC	0.373000													14	29					2.35188e-11	5.24043e-10	7.07596e-05	1	0
PHF2	5253	broad.mit.edu	37	9	96418822	96418822	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr9:96418822C>T	uc004aub.2	+	9	1239	c.1092C>T	c.(1090-1092)CCC>CCT	p.P364P	PHF2_uc011lug.1_Silent_p.P247P	NM_005392	NP_005383	O75151	PHF2_HUMAN	PHD finger protein 2	364					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		CTCAGTTTCCCAACTTTGAAA	0.537000													178	42					0	0	0.000147903	0	0
C9orf21	195827	broad.mit.edu	37	9	99408252	99408252	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr9:99408252C>T	uc004awm.2	-	5	512	c.476G>A	c.(475-477)TGG>TAG	p.W159*		NM_153698	NP_714542	Q7RTV5	CI021_HUMAN	hypothetical protein LOC195827	159							antioxidant activity|oxidoreductase activity			large_intestine(1)	1		Acute lymphoblastic leukemia(62;0.0559)				CACTGCCCGCCACAGGCTCTG	0.453000													46	67					0	0	0.000437636	0	0
ZNF322B	387328	broad.mit.edu	37	9	99961415	99961415	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr9:99961415A>G	uc004axd.1	-	1	496	c.379T>C	c.(379-381)TAT>CAT	p.Y127H	uc004axb.2_5'Flank|ZNF322B_uc004axc.1_5'Flank|uc010msl.1_Intron	NM_199005	NP_945356			zinc finger protein 322B												0		Acute lymphoblastic leukemia(62;0.158)				TCACATGTATAGAATTTTTTA	0.403000													124	36					0	0	0.000147903	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111976086	111976086	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr9:111976086C>T	uc004bdz.1	-	17	1941	c.1646G>A	c.(1645-1647)GGA>GAA	p.G549E		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	549						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						GGCAGGTGTTCCTGGACTCAG	0.502000													45	10					0	0	0.000147903	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112778263	112778263	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr9:112778263G>A	uc004bei.2	+	8	1414	c.1222G>A	c.(1222-1224)GAA>AAA	p.E408K	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.E176K|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.E176K|PALM2-AKAP2_uc004bel.1_5'UTR	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	Error:Variant_position_missing_in_Q9Y2D5_after_alignment							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GCTGCTAAAGGAAGGTGAGTC	0.453000													24	24					0	0	0.000117367	0	0
FAM47B	170062	broad.mit.edu	37	X	34962607	34962607	+	Silent	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrX:34962607C>T	uc004ddi.1	+	1	1677	c.1659C>T	c.(1657-1659)TTC>TTT	p.F553F		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	553										ovary(3)|breast(1)	4						CATGGTACTTCGAGCCTAAGT	0.488000													53	35					0	0	0.000147903	0	0
KIAA2022	340533	broad.mit.edu	37	X	73963454	73963454	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrX:73963454C>T	uc004eby.2	-	3	1555	c.938G>A	c.(937-939)CGA>CAA	p.R313Q		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	313					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						GGATTCATATCGAATTTTCAG	0.423000													34	131					0	0	0.000191422	0	0
NXF3	56000	broad.mit.edu	37	X	102339391	102339391	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrX:102339391T>C	uc004eju.2	-	3	301	c.230A>G	c.(229-231)AAA>AGA	p.K77R	NXF3_uc010noi.1_5'Flank|NXF3_uc011mrw.1_Missense_Mutation_p.K77R|NXF3_uc011mrx.1_5'UTR	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	77						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						AAAACTGCCTTTCCGATTATA	0.433000													50	122					0	0	0.000147903	0	0
TMEM164	84187	broad.mit.edu	37	X	109247307	109247307	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrX:109247307C>A	uc004eom.2	+	2	624	c.305C>A	c.(304-306)ACC>AAC	p.T102N	TMEM164_uc004eol.2_Intron|TMEM164_uc010npq.2_Missense_Mutation_p.T102N	NM_032227	NP_115603	Q5U3C3	TM164_HUMAN	transmembrane protein 164 isoform b	102	Helical; (Potential).					integral to membrane				large_intestine(1)|lung(1)|skin(1)	3						CTGTGCCTGACCTTCGGGGTG	0.587000													50	41					1.61863e-15	3.65567e-14	0.000147903	1	0
ZNF280C	55609	broad.mit.edu	37	X	129370208	129370208	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrX:129370208G>A	uc004evm.2	-	8	905	c.751C>T	c.(751-753)CCT>TCT	p.P251S	ZNF280C_uc010nrf.1_Missense_Mutation_p.P251S	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						TATTTCAAAGGATCCAAAAGA	0.299000													30	101					0	0	8.91981e-05	0	0
IRAK1	3654	broad.mit.edu	37	X	153284759	153284759	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrX:153284759G>A	uc004fjs.1	-	3	404	c.325C>T	c.(325-327)CCG>TCG	p.P109S	IRAK1_uc004fjr.1_Missense_Mutation_p.P109S|IRAK1_uc004fjt.1_Missense_Mutation_p.P109S|IRAK1_uc010nur.2_Missense_Mutation_p.P109S|IRAK1_uc004fju.2_Missense_Mutation_p.P135S	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	109					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGGGACGGAAGCGGGGCG	0.741000													7	15					0	0	0.000442599	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16952495	16952495	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrY:16952495G>A	uc004ftg.2	+	6	2056	c.1804G>A	c.(1804-1806)GAG>AAG	p.E602K	NLGN4Y_uc004fte.2_Missense_Mutation_p.E434K|NLGN4Y_uc011nas.1_Missense_Mutation_p.E622K|NLGN4Y_uc004ftf.2_Missense_Mutation_p.E295K|NLGN4Y_uc004fth.2_Missense_Mutation_p.E602K	NM_014893	NP_055708	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked isoform 1	602	Extracellular (Potential).				brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity				0						CAACTTGAACGAGATATTCCA	0.478000													47	12					0	0	0.000147903	0	0
DNASE2B	58511	broad.mit.edu	37	1	84864322	84864322	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:84864322delG	uc001djt.1	+	1	108	c.75delG	c.(73-75)CTGfs	p.L25fs	UOX_uc009wcg.2_5'Flank	NM_021233	NP_067056	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta isoform 1 precursor	25					DNA metabolic process	lysosome	deoxyribonuclease II activity				0				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		TTGGGGTGCTGGGGGCAGCAA	0.463								Direct_reversal_of_damage					7	3537	---	---	---	---					
WDR63	126820	broad.mit.edu	37	1	85547084	85547084	+	Frame_Shift_Del	DEL	A	-	-			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr1:85547084delA	uc001dkt.2	+	4	462	c.271delA	c.(271-273)AAAfs	p.K91fs	WDR63_uc009wcl.2_Frame_Shift_Del_p.K91fs	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	91										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CCACCCAGTCAAAAAAATTGT	0.383													11	1385	---	---	---	---					
NOX4	50507	broad.mit.edu	37	11	89106662	89106663	+	Splice_Site	INS	-	A	A	rs56022003		TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr11:89106662_89106663insA	uc001pct.2	-	12	1314	c.1075_splice	c.e12-1	p.C359_splice	NOX4_uc009yvr.2_Splice_Site_p.C334_splice|NOX4_uc001pcu.2_Splice_Site_p.C285_splice|NOX4_uc001pcw.2_Splice_Site_p.C52_splice|NOX4_uc001pcx.2_Splice_Site_p.C52_splice|NOX4_uc001pcv.2_Splice_Site_p.C359_splice|NOX4_uc009yvo.2_Splice_Site|NOX4_uc010rtu.1_Splice_Site_p.C193_splice|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Splice_Site_p.C335_splice|NOX4_uc009yvq.2_Splice_Site_p.C335_splice	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AGTTGGACACTAAAAAAAAATA	0.292													8	201	---	---	---	---					
ZNF668	79759	broad.mit.edu	37	16	31073072	31073072	+	Frame_Shift_Del	DEL	G	-	-			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr16:31073072delG	uc010caf.2	-	3	1534	c.1177delC	c.(1177-1179)CACfs	p.H393fs	ZNF668_uc002eao.2_Frame_Shift_Del_p.H393fs	NM_024706	NP_078982	Q96K58	ZN668_HUMAN	zinc finger protein 668	393	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)	4						GCGTTACAGTGGAAGGGGCGC	0.667													61	136	---	---	---	---					
MYPOP	339344	broad.mit.edu	37	19	46404647	46404647	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr19:46404647delC	uc002pdt.2	-	2	472	c.385delG	c.(385-387)GCAfs	p.A129fs		NM_001012643	NP_001012661	Q86VE0	MYPOP_HUMAN	Myb protein P42POP	129						nucleus	DNA binding				0						CCAGCACCTGCCCCCGGCGCC	0.736													2	4	---	---	---	---					
VPS8	23355	broad.mit.edu	37	3	184573590	184573593	+	Frame_Shift_Del	DEL	TTGT	-	-			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chr3:184573590_184573593delTTGT	uc003fpb.1	+	13	1292_1295	c.1121_1124delTTGT	c.(1120-1125)GTTGTTfs	p.V374fs	VPS8_uc010hyd.1_Frame_Shift_Del_p.V374fs	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	376_377							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			AGAGGAGATGTTGTTCATTTTCTA	0.387													60	65	---	---	---	---					
Unknown	0	broad.mit.edu	37	M	15081	15081	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A2JG-06A-11D-A196-08	TCGA-D3-A2JG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9162ca00-4a41-4aa7-b09d-ee52dc6519ea	25855d9c-e92f-4ffd-a399-3c716fdf7b3c	g.chrM:15081delC	uc004coy.2	+	1	321	c.246delC	c.(244-246)AACfs	p.N82fs	uc004coz.1_5'Flank					Homo sapiens clone 35w unknown mRNA; mitochondrial.																		CTACTCAGAAACCTGAAACAT	0.488											OREG0007583	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	2	4	---	---	---	---					
