Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIB2	142678	broad.mit.edu	37	1	1565078	1565078	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:1565078C>T	uc001agg.2	+	19	2924	c.2797C>T	c.(2797-2799)CGC>TGC	p.R933C	MIB2_uc001agh.2_Missense_Mutation_p.R919C|MIB2_uc001agi.2_Missense_Mutation_p.R929C|MIB2_uc001agj.2_Missense_Mutation_p.R774C|MIB2_uc001agk.2_Missense_Mutation_p.R868C|MIB2_uc001agm.2_Missense_Mutation_p.A749V|MIB2_uc010nyq.1_Missense_Mutation_p.R889C|MIB2_uc009vkh.2_Missense_Mutation_p.R739C|MIB2_uc001agn.2_Missense_Mutation_p.R565C|MIB2_uc001ago.2_Missense_Mutation_p.R16C|MMP23B_uc001agp.2_5'Flank|MMP23B_uc001agq.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	933					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CAAGAAACTGCGCCCAGGTGG	0.682													6	8					0	0	0.000157383	0	0
PRDM16	63976	broad.mit.edu	37	1	3334427	3334427	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:3334427G>C	uc001akf.2	+	11	2807	c.2727G>C	c.(2725-2727)GAG>GAC	p.E909D	PRDM16_uc001akc.2_Missense_Mutation_p.E908D|PRDM16_uc001akd.2_Missense_Mutation_p.E908D|PRDM16_uc001ake.2_Missense_Mutation_p.E909D|PRDM16_uc009vlh.2_Missense_Mutation_p.E609D	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	909	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		AGAAGCTGGAGAGCTTTGCAG	0.607			T	EVI1	MDS|AML								51	78					0	0	0.000781405	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3397060	3397060	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:3397060C>T	uc001akg.3	+	15	2287	c.2039C>T	c.(2038-2040)CCC>CTC	p.P680L	ARHGEF16_uc001aki.2_Missense_Mutation_p.P392L|ARHGEF16_uc001akj.2_Missense_Mutation_p.P392L|ARHGEF16_uc010nzh.1_Missense_Mutation_p.P384L	NM_014448	NP_055263	Q5VV41	ARHGG_HUMAN	Rho guanine exchange factor 16	680	SH3.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			ovary(1)	1	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GGATGGTTCCCCGAGGACTTT	0.677													11	27					0	0	0.00185496	0	0
MEGF6	1953	broad.mit.edu	37	1	3412483	3412483	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:3412483G>A	uc001akl.2	-	30	4069	c.3842C>T	c.(3841-3843)CCG>CTG	p.P1281L	MEGF6_uc001akk.2_Missense_Mutation_p.P1046L	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	1281	EGF-like 23.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GGCTCTCCCCGGGGGGCAGAG	0.687													4	12					0	0	0.00024832	0	0
NPHP4	261734	broad.mit.edu	37	1	5964795	5964795	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:5964795G>A	uc001alq.1	-	16	2291	c.2025C>T	c.(2023-2025)TTC>TTT	p.F675F	NPHP4_uc001als.1_RNA|NPHP4_uc009vlt.1_RNA|NPHP4_uc001alt.1_RNA|NPHP4_uc009vlu.1_RNA	NM_015102	NP_055917	O75161	NPHP4_HUMAN	nephroretinin	675					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			pancreas(1)	1	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		TTGCGGGTGGGAAGCGGTAGA	0.597													30	52					0	0	0.000953801	0	0
GPR153	387509	broad.mit.edu	37	1	6314056	6314057	+	Silent	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:6314056_6314057GG>AA	uc001amp.1	-	3	767_768	c.507_508CC>TT	c.(505-510)GGCCTG>GGTTTG	p.169_170GL>GL		NM_207370	NP_997253	Q6NV75	GP153_HUMAN	G protein-coupled receptor 153	169_170	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0	Ovarian(185;0.0634)	all_cancers(23;8.07e-33)|all_epithelial(116;4.45e-18)|all_lung(118;1.09e-06)|all_neural(13;3.68e-06)|Lung NSC(185;1.52e-05)|all_hematologic(16;2.39e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00475)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;1.91e-37)|GBM - Glioblastoma multiforme(13;4.87e-29)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;1.33e-07)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.246)		CCAAAGCCCAGGCCGATCTCAG	0.658													5	13					0	0	6.4e-05	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724103	7724103	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:7724103G>A	uc001aoi.2	+	9	1703	c.1496G>A	c.(1495-1497)GGG>GAG	p.G499E		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	499	Poly-Gly.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CAGACGTACGGGGGTGGAGGC	0.592													25	52					0	0	0.00178596	0	0
RERE	473	broad.mit.edu	37	1	8716118	8716118	+	Missense_Mutation	SNP	G	A	A	rs139888880	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:8716118G>A	uc001ape.2	-	3	1049	c.239C>T	c.(238-240)CCG>CTG	p.P80L	RERE_uc001apf.2_Missense_Mutation_p.P80L|RERE_uc001aph.1_Missense_Mutation_p.P80L	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	80					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTTTTTTTTCGGTGGTTTCTT	0.443													90	162					0	0	0.000781405	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12836088	12836088	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:12836088G>A	uc001aui.2	+	2	717	c.690G>A	c.(688-690)AGG>AGA	p.R230R		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	230										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCCAGATGAGGAATCTCCGCA	0.522													36	51					0	0	0.00148497	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921097	12921097	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:12921097G>A	uc001aum.1	+	4	975	c.888G>A	c.(886-888)GAG>GAA	p.E296E		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	296											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACCCCTTGGAGAACTTGGAAT	0.463													54	74					0	0	0.000781405	0	0
LOC440563	440563	broad.mit.edu	37	1	13183577	13183577	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:13183577C>T	uc010obg.1	-	1	391	c.296G>A	c.(295-297)CGA>CAA	p.R99Q		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	99						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CGCTGCGGATCGTTTCACACC	0.502													11	40					0	0	0.00136819	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16060315	16060315	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:16060315C>T	uc010obo.1	+	20	3173	c.2946C>T	c.(2944-2946)ATC>ATT	p.I982I	SLC25A34_uc001axb.1_5'Flank	NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	982					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ACACGGCGATCCAGGAAGCCT	0.642													21	57					0	0	0.000375601	0	0
SPEN	23013	broad.mit.edu	37	1	16256478	16256478	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:16256478C>T	uc001axk.1	+	11	3947	c.3743C>T	c.(3742-3744)TCA>TTA	p.S1248L	SPEN_uc010obp.1_Missense_Mutation_p.S1207L	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1248					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TACAGAAGTTCACGCCAAATC	0.473													35	42					0	0	0.000692331	0	0
CLCNKA	1187	broad.mit.edu	37	1	16350333	16350333	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:16350333G>A	uc001axu.2	+	3	219	c.139G>A	c.(139-141)GGA>AGA	p.G47R	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Missense_Mutation_p.G47R|CLCNKA_uc010obw.1_Missense_Mutation_p.G47R|CLCNKB_uc001axw.3_Intron	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	47					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	GTTCCGCCTGGGAGAAGACTG	0.597													21	30					0	0	0.000375601	0	0
MST1P2	11209	broad.mit.edu	37	1	16976657	16976657	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:16976657C>T	uc010och.1	+	14		c.2378C>T			MST1P2_uc001azl.3_RNA|MST1P2_uc009vox.2_RNA|MST1P2_uc001azm.3_RNA	NR_027504				Homo sapiens cDNA FLJ43241 fis, clone HEART1000010, weakly  similar to Hepatocyte growth factor-like protein precursor.												0						TGCGCAAGGTCGCGCTGGCCA	0.572													7	76					0	0	0.00198382	0	0
KIF17	57576	broad.mit.edu	37	1	20996944	20996944	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:20996944G>A	uc001bdr.3	-	13	2881	c.2763C>T	c.(2761-2763)ACC>ACT	p.T921T	KIF17_uc001bdp.3_Silent_p.T198T|KIF17_uc001bdq.3_Silent_p.T199T|KIF17_uc009vpx.2_Silent_p.T291T|KIF17_uc001bds.3_Silent_p.T920T	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	921					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		CTGCTGCAGAGGTTTTGCGGG	0.597													23	55					0	0	0.00106085	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447335	24447335	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:24447335A>T	uc001biq.1	-	7	1724	c.1685T>A	c.(1684-1686)CTT>CAT	p.L562H	IL22RA1_uc010oeg.1_Missense_Mutation_p.L494H|IL22RA1_uc009vrb.1_Missense_Mutation_p.L426H|IL22RA1_uc010oeh.1_3'UTR	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	562	Cytoplasmic (Potential).					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GCCTCTGAAAAGAGAATCCAG	0.602													21	36					0	0	0.00106085	0	0
SLC9A1	6548	broad.mit.edu	37	1	27434230	27434230	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:27434230G>A	uc001bnm.2	-	4	1817	c.1191C>T	c.(1189-1191)TTC>TTT	p.F397F	SLC9A1_uc010ofk.1_Silent_p.F58F|SLC9A1_uc001bnn.2_Silent_p.F397F	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	397					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	AGACGCCGAGGAAGATGAAGA	0.607													6	9					0	0	0.000157383	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28271830	28271830	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:28271830C>T	uc001bpg.2	+	2	340	c.149C>T	c.(148-150)TCC>TTC	p.S50F	SMPDL3B_uc001bpf.2_Missense_Mutation_p.S50F|SMPDL3B_uc010ofq.1_5'UTR|SMPDL3B_uc010ofr.1_Missense_Mutation_p.S50F	NM_014474	NP_055289	Q92485	ASM3B_HUMAN	acid sphingomyelinase-like phosphodiesterase 3B	50					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			ovary(3)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		TCAGCTGGATCCCAGCCAGTG	0.577													12	26					0	0	0.000978159	0	0
SDC3	9672	broad.mit.edu	37	1	31347418	31347418	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:31347418G>A	uc001bse.2	-	4	935	c.888C>T	c.(886-888)ACC>ACT	p.T296T	SDC3_uc001bsd.2_Silent_p.T238T	NM_014654	NP_055469	O75056	SDC3_HUMAN	syndecan 3	296	Extracellular (Potential).|Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTCAGGAAGGTCTCTGGAG	0.582													16	54					0	0	0.000422831	0	0
ZCCHC17	51538	broad.mit.edu	37	1	31811831	31811831	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:31811831C>T	uc001bsp.1	+	5	389	c.253C>T	c.(253-255)CTC>TTC	p.L85F	ZCCHC17_uc001bsq.1_Missense_Mutation_p.L77F|ZCCHC17_uc010ogf.1_Missense_Mutation_p.L61F|ZCCHC17_uc009vtu.1_Missense_Mutation_p.L61F|ZCCHC17_uc001bsr.1_Missense_Mutation_p.L85F|ZCCHC17_uc009vtv.1_Missense_Mutation_p.L61F	NM_016505	NP_057589	Q9NP64	NO40_HUMAN	zinc finger, CCHC domain containing 17	85	S1 motif.					nucleolus	RNA binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|all_neural(195;0.146)|Medulloblastoma(700;0.151)|Breast(348;0.222)		STAD - Stomach adenocarcinoma(196;0.0215)|READ - Rectum adenocarcinoma(331;0.168)		AAAAGTATCCCTCTCCATGAA	0.343													17	36					0	0	0.00121646	0	0
CSMD2	114784	broad.mit.edu	37	1	34033298	34033298	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:34033298C>T	uc001bxn.1	-	54	8235	c.8206G>A	c.(8206-8208)GGC>AGC	p.G2736S	CSMD2_uc001bxm.1_Missense_Mutation_p.G2759S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2736	Sushi 18.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACCACACTGCCCCGGTAGCTG	0.567													5	20					0	0	0.000602214	0	0
CLSPN	63967	broad.mit.edu	37	1	36225975	36225975	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:36225975G>A	uc001bzi.2	-	8	1627	c.1547C>T	c.(1546-1548)TCC>TTC	p.S516F	CLSPN_uc009vux.2_Missense_Mutation_p.S516F	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	516					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TATCACAAAGGAATCTTCATC	0.438													13	29					0	0	0.000422831	0	0
EIF2C1	26523	broad.mit.edu	37	1	36359681	36359681	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:36359681C>T	uc001bzl.2	+	6	906	c.693C>T	c.(691-693)TTC>TTT	p.F231F	EIF2C1_uc001bzk.2_Silent_p.F156F|EIF2C1_uc009vuy.2_5'Flank	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	231	PAZ.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TGATTGAGTTCATGTGTGAGG	0.527													29	44					0	0	0.0024448	0	0
MAP7D1	55700	broad.mit.edu	37	1	36644056	36644057	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:36644056_36644057CC>TT	uc001bzz.2	+	10	1961_1962	c.1745_1746CC>TT	c.(1744-1746)CCC>CTT	p.P582L	MAP7D1_uc001caa.2_Missense_Mutation_p.P550L|MAP7D1_uc001cab.2_Missense_Mutation_p.P545L|MAP7D1_uc001cac.2_Missense_Mutation_p.P282L|MAP7D1_uc001cad.2_Missense_Mutation_p.P119L	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	582	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				GCCCCTGCTCCCCCGGTGACCC	0.683													5	6					0	0	6.4e-05	0	0
HEYL	26508	broad.mit.edu	37	1	40092735	40092735	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:40092735G>A	uc001cdp.2	-	5	482	c.431C>T	c.(430-432)CCC>CTC	p.P144L	HEYL_uc010oiw.1_Missense_Mutation_p.P116L	NM_014571	NP_055386	Q9NQ87	HEYL_HUMAN	hairy/enhancer-of-split related with YRPW	144	Orange.				multicellular organismal development|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.1e-18)|Epithelial(16;2.77e-17)|all cancers(16;5.64e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			AATCCGGACGGGGTCTGCACG	0.647													21	24					0	0	0.00188189	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045916	42045916	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:42045916G>A	uc001cgz.3	-	4	5766	c.4553C>T	c.(4552-4554)CCT>CTT	p.P1518L	HIVEP3_uc001cha.3_Missense_Mutation_p.P1518L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1518					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGACAATGCAGGGTGAGGGAG	0.567													24	37					0	0	0.000375601	0	0
WDR65	149465	broad.mit.edu	37	1	43663223	43663223	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:43663223G>A	uc001cip.1	+	7	1244	c.1123_splice	c.e7-1	p.G375_splice	EBNA1BP2_uc001cio.2_Intron|WDR65_uc010ojz.1_Splice_Site_p.G364_splice|WDR65_uc001ciq.1_Splice_Site_p.G375_splice	NM_152498	NP_689711	Q96MR6	WDR65_HUMAN	WD repeat domain 65											skin(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATTTCTCTAGGGGGAGCCTG	0.483													56	76					0	0	0.000781405	0	0
TIE1	7075	broad.mit.edu	37	1	43773242	43773242	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:43773242A>C	uc001ciu.2	+	6	991	c.912A>C	c.(910-912)GAA>GAC	p.E304D	TIE1_uc010okd.1_Missense_Mutation_p.E304D|TIE1_uc010oke.1_Missense_Mutation_p.E259D|TIE1_uc009vwq.2_Missense_Mutation_p.E260D|TIE1_uc010okf.1_5'UTR|TIE1_uc010okg.1_5'UTR|TIE1_uc010okc.1_Missense_Mutation_p.E304D	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	304	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGTGCCAAGAAGGTATGCCTA	0.612													17	34					0	0	0.00152264	0	0
PTPRF	5792	broad.mit.edu	37	1	44083415	44083416	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:44083415_44083416GG>AA	uc001cjr.2	+	25	4544_4545	c.4204_4205GG>AA	c.(4204-4206)GGG>AAG	p.G1402K	PTPRF_uc001cjs.2_Missense_Mutation_p.G1393K|PTPRF_uc001cju.2_Missense_Mutation_p.G791K|PTPRF_uc009vwt.2_Missense_Mutation_p.G962K|PTPRF_uc001cjv.2_Missense_Mutation_p.G873K|PTPRF_uc001cjw.2_Missense_Mutation_p.G628K	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1402	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGGCGTCCCCGGGAGTGACTAC	0.594													10	20					0	0	6.4e-05	0	0
MUTYH	4595	broad.mit.edu	37	1	45797397	45797397	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:45797397G>A	uc001cnm.2	-	12	1329	c.1113C>T	c.(1111-1113)ACC>ACT	p.T371T	MUTYH_uc009vxn.2_Silent_p.T196T|MUTYH_uc001cnf.2_Silent_p.T346T|MUTYH_uc009vxo.2_Silent_p.T346T|MUTYH_uc001cng.2_Silent_p.T357T|MUTYH_uc001cnj.2_Silent_p.T254T|MUTYH_uc001cni.2_Silent_p.T346T|MUTYH_uc001cnh.2_Silent_p.T347T|MUTYH_uc001cno.2_Silent_p.T254T|MUTYH_uc001cnk.2_Silent_p.T231T|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Silent_p.T360T|MUTYH_uc009vxp.2_Silent_p.T374T|MUTYH_uc001cnn.2_Silent_p.T361T	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	371	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					CCAGAACACAGGTGGCAGAGC	0.647			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				11	20					0	0	0.000978159	0	0
CYP4B1	1580	broad.mit.edu	37	1	47276530	47276530	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:47276530C>T	uc001cqm.3	+	2	315	c.231C>T	c.(229-231)TTC>TTT	p.F77F	CYP4B1_uc009vyl.1_5'UTR|CYP4B1_uc001cqn.3_Silent_p.F77F|CYP4B1_uc009vym.2_Silent_p.F77F|CYP4B1_uc010omk.1_Intron|CYP4B1_uc010oml.1_5'Flank	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	77					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCCACCAGTTCCCGTATGCCC	0.552													15	27					0	0	0.000308642	0	0
PARS2	25973	broad.mit.edu	37	1	55223545	55223545	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:55223545G>A	uc001cxy.2	-	2	1373	c.1290C>T	c.(1288-1290)TAC>TAT	p.Y430Y		NM_152268	NP_689481	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase (mitochondrial)(putative)	430					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			ovary(2)	2					L-Proline(DB00172)	TCACAAAGGGGTAGCCAAACT	0.547													31	68					0	0	0.00178596	0	0
BSND	7809	broad.mit.edu	37	1	55474242	55474242	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:55474242G>A	uc001cye.2	+	4	1147	c.904G>A	c.(904-906)GGA>AGA	p.G302R		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	302	Cytoplasmic (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)|skin(1)	2						GCTGCCAGATGGAGCCGGGGA	0.582													20	48					0	0	0.00188189	0	0
C1orf168	199920	broad.mit.edu	37	1	57258437	57258437	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:57258437G>A	uc001cym.3	-	2	455	c.49C>T	c.(49-51)CAA>TAA	p.Q17*	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Nonsense_Mutation_p.Q17*	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	17										ovary(3)|skin(2)	5						TCAAGATTTTGAAATTTGGCT	0.348													84	174					0	0	0.000781405	0	0
C8B	732	broad.mit.edu	37	1	57399055	57399055	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:57399055G>A	uc001cyp.2	-	10	1572	c.1505C>T	c.(1504-1506)TCC>TTC	p.S502F	C8B_uc010oon.1_Missense_Mutation_p.S440F|C8B_uc010ooo.1_Missense_Mutation_p.S450F	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	502	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						ACAGTGGCAGGAACTAACTTC	0.522													29	39					0	0	0.00106085	0	0
C1orf87	127795	broad.mit.edu	37	1	60463316	60463316	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:60463316T>C	uc001czs.1	-	11	1537	c.1445A>G	c.(1444-1446)GAA>GGA	p.E482G	C1orf87_uc001czr.1_Missense_Mutation_p.E74G	NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	482							calcium ion binding			ovary(1)|breast(1)	2						GAGGGCATTTTCCAGCTTCCT	0.463													28	47					0	0	0.00209593	0	0
INADL	10207	broad.mit.edu	37	1	62545209	62545209	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:62545209C>A	uc001dab.2	+	32	4327	c.4213C>A	c.(4213-4215)CAT>AAT	p.H1405N	INADL_uc009waf.1_Missense_Mutation_p.H1405N|INADL_uc001daa.2_Missense_Mutation_p.H1405N|INADL_uc001dad.3_Missense_Mutation_p.H1102N|INADL_uc001dac.2_RNA|INADL_uc010oot.1_Missense_Mutation_p.H189N|INADL_uc009wag.2_Missense_Mutation_p.H189N|INADL_uc010oou.1_Missense_Mutation_p.H78N|hsa-mir-3116-2|MI0014129_5'Flank	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1405					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						TTCATCATACCATTCAACAGA	0.413													7	115					0.000157383	0.000649982	0.000157383	1	0
PGM1	5236	broad.mit.edu	37	1	64095113	64095113	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:64095113C>T	uc001dbh.2	+	2	477	c.264C>T	c.(262-264)ATC>ATT	p.I88I	PGM1_uc010ooy.1_5'UTR|PGM1_uc010ooz.1_Silent_p.I106I	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	88					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GCTTGGTTATCGGACAGAATG	0.473													46	72					0	0	0.000781405	0	0
CACHD1	57685	broad.mit.edu	37	1	65143967	65143967	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:65143967C>T	uc001dbo.1	+	23	3170	c.3065C>T	c.(3064-3066)CCC>CTC	p.P1022L	CACHD1_uc001dbp.1_Missense_Mutation_p.P777L|CACHD1_uc001dbq.1_Missense_Mutation_p.P777L|CACHD1_uc010opa.1_Missense_Mutation_p.P266L	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1073	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						GCCAAAAGTCCCTACGTTGAT	0.458													19	14					0	0	0.00152264	0	0
LPHN2	23266	broad.mit.edu	37	1	82408771	82408771	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:82408771C>T	uc001dit.3	+	6	697	c.516C>T	c.(514-516)TTC>TTT	p.F172F	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.F172F|LPHN2_uc001div.2_Silent_p.F172F|LPHN2_uc009wcd.2_Silent_p.F172F	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	172	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AAATTTATTTCATGCCCTGGA	0.398													25	34					0	0	0.000375601	0	0
TTLL7	79739	broad.mit.edu	37	1	84408234	84408234	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:84408234G>A	uc001djc.2	-	7	1031	c.635C>T	c.(634-636)TCG>TTG	p.S212L	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_Intron|TTLL7_uc001djf.2_Intron|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	212	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		TGGATCACACGATGTAACCAG	0.373													22	39					0	0	0.000375601	0	0
GBP4	115361	broad.mit.edu	37	1	89652711	89652711	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:89652711G>A	uc001dnb.2	-	9	1601	c.1485C>T	c.(1483-1485)GCC>GCT	p.A495A		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	495						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		CAGCAGTGAGGGCTTTGTCTG	0.527													33	57					0	0	0.000692331	0	0
HFM1	164045	broad.mit.edu	37	1	91859874	91859874	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:91859874G>A	uc001doa.3	-	4	370	c.270C>T	c.(268-270)TTC>TTT	p.F90F	HFM1_uc010osu.1_Intron|HFM1_uc010osv.1_Intron|HFM1_uc001doc.1_Silent_p.F90F	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	90							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		AGGCAAACTGGAATTTTTGTG	0.308													21	19					0	0	0.00121646	0	0
RPL5	6125	broad.mit.edu	37	1	93298949	93298949	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:93298949T>C	uc001doz.2	+	2	85	c.7T>C	c.(7-9)TTT>CTT	p.F3L	FAM69A_uc001dpc.2_Intron|RPL5_uc001dpa.2_RNA|RPL5_uc001dpb.2_5'UTR|RPL5_uc001dpd.2_5'Flank	NM_000969	NP_000960	P46777	RL5_HUMAN	ribosomal protein L5	3					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome				0		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		CTTTAAGGGGTTTGTTAAAGT	0.299													16	30					0	0	0.000422831	0	0
DPYD	1806	broad.mit.edu	37	1	98060686	98060687	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:98060686_98060687CC>TT	uc001drv.2	-	9	1023_1024	c.886_887GG>AA	c.(886-888)GGC>AAC	p.G296N		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	296					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CTGCGTCAGGCCTTGGAAGATG	0.371													32	75					0	0	6.4e-05	0	0
CCDC76	54482	broad.mit.edu	37	1	100613780	100613780	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:100613780C>T	uc001dsv.2	+	10	1167	c.1148C>T	c.(1147-1149)TCA>TTA	p.S383L	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Intron	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	383					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		TTGGAAACCTCAAATAGTACC	0.433													33	43					0	0	0.000491102	0	0
COL11A1	1301	broad.mit.edu	37	1	103343611	103343611	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:103343611G>A	uc001dul.2	-	67	5703	c.5385C>T	c.(5383-5385)TTC>TTT	p.F1795F	COL11A1_uc001duk.2_Silent_p.F991F|COL11A1_uc001dum.2_Silent_p.F1807F|COL11A1_uc001dun.2_Silent_p.F1756F|COL11A1_uc009weh.2_Silent_p.F1679F	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1795	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTCAAATCCGAACTTCTGAT	0.348													23	44					0	0	0.00106085	0	0
COL11A1	1301	broad.mit.edu	37	1	103449719	103449719	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:103449719C>T	uc001dul.2	-	31	2849	c.2531G>A	c.(2530-2532)GGA>GAA	p.G844E	COL11A1_uc001duk.2_Missense_Mutation_p.D35N|COL11A1_uc001dum.2_Missense_Mutation_p.G856E|COL11A1_uc001dun.2_Missense_Mutation_p.G805E|COL11A1_uc009weh.2_Missense_Mutation_p.G728E	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	844	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCCTGGATATCCTGGTAATCC	0.224													15	25					0	0	0.000958276	0	0
CELSR2	1952	broad.mit.edu	37	1	109807531	109807531	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:109807531C>T	uc001dxa.3	+	12	5567	c.5506C>T	c.(5506-5508)CCG>TCG	p.P1836S		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	1836	Extracellular (Potential).|EGF-like 6; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TGACCTGAACCCGTGTGAGCA	0.567													157	278					0	0	0.000781405	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110029688	110029688	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:110029688C>T	uc001dxr.2	+	4	373	c.358C>T	c.(358-360)CCT>TCT	p.P120S	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2	120										ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		ACCTCCAGCCCCTGCCAGCTC	0.592													83	151					0	0	0.000781405	0	0
HBXIP	10542	broad.mit.edu	37	1	110950356	110950356	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:110950356G>A	uc001dzr.2	-	1	191	c.133C>T	c.(133-135)CCT>TCT	p.P45S		NM_006402	NP_006393	O43504	HBXIP_HUMAN	hepatitis B virus x-interacting protein	Error:Variant_position_missing_in_O43504_after_alignment					anti-apoptosis|negative regulation of caspase activity|response to virus|viral genome replication	cytosol	protein binding			large_intestine(1)|ovary(1)|pancreas(1)	3		all_cancers(81;4.08e-06)|all_epithelial(167;4.38e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0237)|all cancers(265;0.0675)|Epithelial(280;0.0732)|Colorectal(144;0.102)|LUSC - Lung squamous cell carcinoma(189;0.134)		GCCTCCAAAGGGACAAAATTG	0.627													8	27					0	0	0.000673444	0	0
CD53	963	broad.mit.edu	37	1	111437015	111437015	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:111437015G>A	uc001dzw.2	+	5	490	c.319G>A	c.(319-321)GAA>AAA	p.E107K	CD53_uc001dzx.2_Missense_Mutation_p.E107K|CD53_uc010owa.1_Missense_Mutation_p.E107K|CD53_uc001dzy.2_Missense_Mutation_p.E107K	NM_001040033	NP_001035122	P19397	CD53_HUMAN	CD53 antigen	107	Extracellular (Potential).				signal transduction	integral to membrane|plasma membrane					0		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		CTTTGTATATGAACAGAAGGT	0.408													22	59					0	0	0.00047179	0	0
SPAG17	200162	broad.mit.edu	37	1	118644447	118644447	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:118644447C>T	uc001ehk.2	-	5	618	c.550G>A	c.(550-552)GAT>AAT	p.D184N		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	184	Lys-rich.					cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TCAGGCTGATCCTTTCCCTTT	0.463													50	83					0	0	0.000781405	0	0
NOTCH2	4853	broad.mit.edu	37	1	120469126	120469126	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:120469126G>A	uc001eik.2	-	24	4257	c.4001C>T	c.(4000-4002)CCC>CTC	p.P1334L		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1334	EGF-like 34.|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTTACCGGGGGACAACGGCA	0.488			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				55	118					0	0	0.000781405	0	0
NOTCH2NL	388677	broad.mit.edu	37	1	145281446	145281446	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:145281446C>A	uc001emn.3	+	4	746	c.376C>A	c.(376-378)CAG>AAG	p.Q126K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Missense_Mutation_p.Q126K|NOTCH2NL_uc001emo.2_Missense_Mutation_p.Q126K|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	126	EGF-like 4.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						TGTGGCCAACCAGTTCTCCTG	0.517													15	870					0.000958276	0.00394845	0.000958276	1	0
GJA8	2703	broad.mit.edu	37	1	147380300	147380300	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:147380300C>T	uc001epu.1	+	2	281	c.218C>T	c.(217-219)TCC>TTC	p.S73F		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	73	Extracellular (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					TTTCCCATCTCCCACATTCGC	0.622													15	34					0	0	0.000422831	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783859	149783859	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:149783859G>A	uc001esr.2	-	1	70	c.20C>T	c.(19-21)TCC>TTC	p.S7F	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.S7F|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.S7F	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	7					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					AGCAGGAGCGGATTTCGCTGG	0.502													38	72					0	0	0.000781405	0	0
MCL1	4170	broad.mit.edu	37	1	150551359	150551360	+	Missense_Mutation	DNP	AA	GC	GC			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:150551359_150551360AA>GC	uc001euz.2	-	1	777_778	c.647_648TT>GC	c.(646-648)GTT>GGC	p.V216G	MCL1_uc010pch.1_Missense_Mutation_p.V106G|MCL1_uc001eva.2_Missense_Mutation_p.V216G	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	216	BH3.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CGCCATCCCCAACCCGTCGTAA	0.619													13	35					0	0	6.4e-05	0	0
VPS72	6944	broad.mit.edu	37	1	151149261	151149261	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:151149261G>A	uc001exe.1	-	6	997	c.954C>T	c.(952-954)ATC>ATT	p.I318I	TMOD4_uc001exd.2_5'Flank|TMOD4_uc001exc.3_5'Flank|TMOD4_uc010pct.1_5'Flank	NM_005997	NP_005988	Q15906	VPS72_HUMAN	transcription factor-like 1	318			I -> V (in a breast cancer sample; somatic mutation).		chromatin modification|negative regulation of transcription from RNA polymerase II promoter	nucleus|protein complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.I318V(1)		breast(1)|pancreas(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCTCACGAATGATCTTGAAGG	0.602													32	60					0	0	0.000491102	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059653	152059653	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:152059653G>A	uc001ezo.1	-	3	570	c.505C>T	c.(505-507)CCA>TCA	p.P169S		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	169							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GCTTCTCCTGGAAAGTTGTGA	0.438													33	58					0	0	0.000814825	0	0
RPTN	126638	broad.mit.edu	37	1	152129412	152129412	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:152129412C>T	uc001ezs.1	-	3	228	c.163G>A	c.(163-165)GAA>AAA	p.E55K		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	55	S-100-like (By similarity).|EF-hand 2.					proteinaceous extracellular matrix	calcium ion binding				0						AAGATGGTTTCCACAGTCTCT	0.418													16	57					0	0	0.000958276	0	0
SPRR3	6707	broad.mit.edu	37	1	152975642	152975642	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:152975642G>A	uc001fax.3	+	3	296	c.146G>A	c.(145-147)GGA>GAA	p.G49E	SPRR3_uc001faz.3_Missense_Mutation_p.G49E|SPRR3_uc001fay.2_Missense_Mutation_p.G49E	NM_005416	NP_005407	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	49	1.|14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			skin(1)	1	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCACAACCTGGAAACACAAAG	0.547													10	12					0	0	0.000673444	0	0
S100A7L2	645922	broad.mit.edu	37	1	153409599	153409599	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:153409599C>T	uc010pdx.1	-	3	352	c.274G>A	c.(274-276)GAT>AAT	p.D92N		NM_001045479	NP_001038944			S100 calcium binding protein A7-like 2											ovary(1)	1	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATGGTTATATCCCCCAGCAAG	0.473													57	72					0	0	0.000781405	0	0
CREB3L4	148327	broad.mit.edu	37	1	153946380	153946380	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:153946380G>A	uc001fdn.3	+	10	1293	c.1027G>A	c.(1027-1029)GTA>ATA	p.V343I	CREB3L4_uc010pef.1_Missense_Mutation_p.V196I|CREB3L4_uc001fdo.3_Missense_Mutation_p.V323I|CREB3L4_uc001fdm.1_Missense_Mutation_p.V343I|CREB3L4_uc001fdp.1_Missense_Mutation_p.V323I|CREB3L4_uc001fdr.2_Missense_Mutation_p.V343I|CREB3L4_uc001fdq.2_Missense_Mutation_p.V323I	NM_130898	NP_570968	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like	343	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCACAAGGACGTAACAGAAAA	0.532													11	13					0	0	0.00136819	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317908	154317908	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:154317908G>T	uc001fex.2	+	23	2680	c.2680G>T	c.(2680-2682)GGG>TGG	p.G894W		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	880	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCTGGTGCATGGGCGCTGGTC	0.527											OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	304					3.86212e-05	0.000159626	0.000673444	1	0
CLK2	1196	broad.mit.edu	37	1	155236605	155236605	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:155236605G>A	uc001fjy.2	-	7	1043	c.753C>T	c.(751-753)TTC>TTT	p.F251F	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Silent_p.F250F|CLK2_uc001fjx.2_Silent_p.F23F|CLK2_uc009wqm.2_Silent_p.F251F	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	251	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGAGGAAATCGAAGGTGCTAA	0.547								Other_conserved_DNA_damage_response_genes					10	22					0	0	0.000673444	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155920998	155920998	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:155920998C>T	uc001fmt.2	-	20	2443	c.2325G>A	c.(2323-2325)GAG>GAA	p.E775E	ARHGEF2_uc001fmq.2_Silent_p.E13E|ARHGEF2_uc001fmr.2_Silent_p.E747E|ARHGEF2_uc001fms.2_Silent_p.E774E|ARHGEF2_uc001fmu.2_Silent_p.E819E	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2	775					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGCACAGCTTCTCCCGCCGCT	0.642													7	17					0	0	0.00198382	0	0
FCRL3	115352	broad.mit.edu	37	1	157667645	157667645	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:157667645C>T	uc001frb.2	-	5	655	c.363G>A	c.(361-363)CAG>CAA	p.Q121Q	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.Q121Q|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Silent_p.Q121Q	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	121	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					TGTCTTTCCCCTGACATCTCA	0.418													34	57					0	0	0.000491102	0	0
CD1C	911	broad.mit.edu	37	1	158262012	158262012	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:158262012G>A	uc001fru.2	+	3	759	c.467G>A	c.(466-468)GGA>GAA	p.G156E	CD1C_uc001frv.2_5'UTR	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	156	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					CCAGGCTGTGGAAGTTTGGCC	0.448													66	121					0	0	0.000781405	0	0
CD1E	913	broad.mit.edu	37	1	158325209	158325209	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:158325209C>T	uc001fse.2	+	3	714	c.475C>T	c.(475-477)CCA>TCA	p.P159S	CD1E_uc010pid.1_Missense_Mutation_p.P157S|CD1E_uc010pie.1_Missense_Mutation_p.P60S|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.P159S|CD1E_uc001fsk.2_Intron|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.P159S|CD1E_uc001fry.2_Missense_Mutation_p.P159S|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.P159S|CD1E_uc009wsv.2_Missense_Mutation_p.P60S|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	159					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GGAGCCATCTCCAGGAGCAGG	0.468													27	55					0	0	0.00127121	0	0
OR10X1	128367	broad.mit.edu	37	1	158549411	158549411	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:158549411G>A	uc010pin.1	-	1	279	c.279C>T	c.(277-279)ATC>ATT	p.I93I		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCTTGGGGACGATGGTCAGCG	0.502													15	33					0	0	0.000308642	0	0
SPTA1	6708	broad.mit.edu	37	1	158622276	158622276	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:158622276T>A	uc001fst.1	-	23	3555	c.3356A>T	c.(3355-3357)AAG>ATG	p.K1119M		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1119	Spectrin 11.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTCATCAAACTTTTTCTGCAG	0.398													32	56					0	0	0.00111076	0	0
CADM3	57863	broad.mit.edu	37	1	159166699	159166699	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:159166699G>A	uc001ftl.2	+	7	943	c.801G>A	c.(799-801)TGG>TGA	p.W267*	CADM3_uc009wsy.1_Nonsense_Mutation_p.W221*|CADM3_uc001ftk.2_Nonsense_Mutation_p.W301*|uc001ftm.1_RNA	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	267	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					AGTACCTATGGGAGAAGGAGG	0.537													19	48					0	0	0.000958276	0	0
IGSF9	57549	broad.mit.edu	37	1	159897632	159897632	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:159897632G>A	uc001fur.2	-	20	3474	c.3276C>T	c.(3274-3276)TTC>TTT	p.F1092F	IGSF9_uc001fuq.2_Silent_p.F1076F|CCDC19_uc001ful.2_5'Flank|TAGLN2_uc001fun.1_5'Flank|TAGLN2_uc001fuo.1_5'Flank|TAGLN2_uc010piy.1_5'Flank|IGSF9_uc001fup.2_Silent_p.F238F	NM_001135050	NP_001128522	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9 isoform a	1092	Cytoplasmic (Potential).					cell junction|integral to membrane|synapse				ovary(2)|central_nervous_system(2)|large_intestine(1)	5	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTCCCCAGGGAATTCTGAGT	0.522													9	28					0	0	0.000673444	0	0
VANGL2	57216	broad.mit.edu	37	1	160389128	160389128	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:160389128C>T	uc001fwb.1	+	5	828	c.529C>T	c.(529-531)CGC>TGC	p.R177C	VANGL2_uc001fwc.1_Missense_Mutation_p.R177C	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	177	Cytoplasmic (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTCGCTGCCCCGCGTCTTTGT	0.627													46	53					0	0	0.000781405	0	0
OLFML2B	25903	broad.mit.edu	37	1	161953983	161953983	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:161953983G>A	uc001gbu.2	-	8	2159	c.1735C>T	c.(1735-1737)CGC>TGC	p.R579C	OLFML2B_uc001gbt.2_Missense_Mutation_p.R62C|OLFML2B_uc010pkq.1_Missense_Mutation_p.R580C	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	579	Olfactomedin-like.									skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			GTGAAGGCGCGATTGTAGTAG	0.597													16	37					0	0	0.000422831	0	0
LMX1A	4009	broad.mit.edu	37	1	165175136	165175136	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:165175136G>A	uc001gcy.1	-	7	1174	c.953C>T	c.(952-954)CCA>CTA	p.P318L	LMX1A_uc001gcz.1_Missense_Mutation_p.P318L|LMX1A_uc001gcw.1_Missense_Mutation_p.P36L|LMX1A_uc001gcx.1_Missense_Mutation_p.P69L	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	318						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CATCTGGGGTGGGGTGAGACC	0.572													28	34					0	0	0.00209593	0	0
MAEL	84944	broad.mit.edu	37	1	166990344	166990344	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:166990344G>A	uc001gdy.1	+	11	1135	c.1064G>A	c.(1063-1065)GGA>GAA	p.G355E	MAEL_uc001gdz.1_Missense_Mutation_p.G324E|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	355					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						GGGAGTTCAGGATTCTCTCAT	0.358													27	34					0	0	0.00178596	0	0
F5	2153	broad.mit.edu	37	1	169511239	169511239	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:169511239C>T	uc001ggg.1	-	13	3234	c.3089G>A	c.(3088-3090)CGA>CAA	p.R1030Q		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1030	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTTCTTTTTTCGTGTCTTAAT	0.408													57	116					0	0	0.000781405	0	0
SELP	6403	broad.mit.edu	37	1	169580879	169580879	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:169580879C>T	uc001ggi.3	-	7	1063	c.998G>A	c.(997-999)GGA>GAA	p.G333E	SELP_uc001ggh.2_Missense_Mutation_p.G168E|SELP_uc009wvr.2_Missense_Mutation_p.G333E	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	333	Sushi 3.|Extracellular (Potential).				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GTCCATGGTTCCTTCACTGGG	0.517													25	64					0	0	0.00127121	0	0
DNM3	26052	broad.mit.edu	37	1	172007556	172007556	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:172007556A>T	uc001gie.2	+	7	1123	c.947A>T	c.(946-948)AAT>ATT	p.N316I	DNM3_uc001gid.3_Missense_Mutation_p.N316I|DNM3_uc009wwb.2_Missense_Mutation_p.N316I|DNM3_uc001gif.2_Missense_Mutation_p.N316I	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	316					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						GCCTACAAAAATTTCAAACCA	0.413													44	70					0	0	0.000781405	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668404	176668404	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:176668404C>T	uc001gkz.2	+	8	4079	c.2915C>T	c.(2914-2916)TCC>TTC	p.S972F	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	972					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGGGTCACTTCCTTCTTCATG	0.557													44	101					0	0	0.000509022	0	0
ASTN1	460	broad.mit.edu	37	1	176927571	176927571	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:176927571C>T	uc001glc.2	-	10	1858	c.1646G>A	c.(1645-1647)AGC>AAC	p.S549N	ASTN1_uc001glb.1_Missense_Mutation_p.S549N|ASTN1_uc001gld.1_Missense_Mutation_p.S549N|ASTN1_uc009wwx.1_Missense_Mutation_p.S549N	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	557					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						AATCACAAAGCTCTTGCTGAG	0.562													6	15					0	0	0.00116845	0	0
TDRD5	163589	broad.mit.edu	37	1	179631290	179631290	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:179631290G>A	uc001gnf.1	+	14	2462	c.2212G>A	c.(2212-2214)GAT>AAT	p.D738N	TDRD5_uc010pnp.1_Missense_Mutation_p.D792N|TDRD5_uc001gnh.1_Missense_Mutation_p.D293N	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	738					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CATAGGTGATGATATTTGGGA	0.423													31	43					0	0	0.00058488	0	0
CACNA1E	777	broad.mit.edu	37	1	181727957	181727957	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:181727957G>A	uc001gow.2	+	32	4723	c.4558G>A	c.(4558-4560)GTG>ATG	p.V1520M	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1408M|CACNA1E_uc001gox.1_Missense_Mutation_p.V746M|CACNA1E_uc009wxt.2_Missense_Mutation_p.V746M	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1520	Helical; Name=S2 of repeat IV.|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CTTCACCATGGTGTTTTCCCT	0.473													36	49					0	0	0.000680045	0	0
GLUL	2752	broad.mit.edu	37	1	182354631	182354631	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:182354631G>C	uc001gpa.1	-	6	876	c.664C>G	c.(664-666)CGT>GGT	p.R222G	GLUL_uc010pnt.1_Missense_Mutation_p.R9G|GLUL_uc001gpb.1_Missense_Mutation_p.R222G|GLUL_uc001gpc.1_Missense_Mutation_p.R222G|GLUL_uc001gpd.1_Missense_Mutation_p.R222G	NM_001033056	NP_001028228	P15104	GLNA_HUMAN	glutamine synthetase	222					cell proliferation|glutamine biosynthetic process|neurotransmitter uptake	cytosol|Golgi apparatus|mitochondrion	ATP binding|glutamate decarboxylase activity|glutamate-ammonia ligase activity|identical protein binding				0					Asparaginase(DB00023)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)|L-Methionine(DB00134)	AAGATGAAACGGGCCACCCAG	0.473													3	55					0	0	0.00024832	0	0
DHX9	1660	broad.mit.edu	37	1	182812436	182812436	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:182812436T>G	uc001gpr.2	+	3	282	c.119T>G	c.(118-120)GTG>GGG	p.V40G	DHX9_uc001gps.2_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	40	DRBM 1.|Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AAGGTTCAGGTGGAAGGTTAT	0.333													6	28					0	0	0.00136819	0	0
SMG7	9887	broad.mit.edu	37	1	183515287	183515287	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:183515287C>T	uc001gqg.2	+	17	2679	c.2557C>T	c.(2557-2559)CCC>TCC	p.P853S	SMG7_uc010pob.1_Missense_Mutation_p.P836S|SMG7_uc001gqf.2_Missense_Mutation_p.P807S|SMG7_uc001gqh.2_Missense_Mutation_p.P807S|SMG7_uc001gqi.2_Missense_Mutation_p.P765S|SMG7_uc010poc.1_Missense_Mutation_p.P811S	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	853					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GAAGCCTTTTCCCATGGAGCC	0.448													29	38					0	0	0.00127121	0	0
HMCN1	83872	broad.mit.edu	37	1	186043883	186043883	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:186043883C>T	uc001grq.1	+	53	8379	c.8150C>T	c.(8149-8151)TCC>TTC	p.S2717F		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2717	Ig-like C2-type 25.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CCCCTTAAATCCGATGATCAT	0.353													15	29					0	0	0.00074312	0	0
PRG4	10216	broad.mit.edu	37	1	186276363	186276363	+	Silent	SNP	G	A	A	rs113621509		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:186276363G>A	uc001gru.3	+	7	1563	c.1512G>A	c.(1510-1512)AAG>AAA	p.K504K	PRG4_uc001grt.3_Silent_p.K463K|PRG4_uc009wyl.2_Silent_p.K411K|PRG4_uc009wym.2_Silent_p.K370K|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	504	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|21.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCACTCCCAAGGAGCCTGCAC	0.647													13	30					0	0	0.00185496	0	0
TPR	7175	broad.mit.edu	37	1	186313130	186313130	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:186313130G>A	uc001grv.2	-	26	3807	c.3510C>T	c.(3508-3510)GTC>GTT	p.V1170V		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1170	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		CAGAGGCAACGACCTTGTCAC	0.388			T	NTRK1	papillary thyroid								19	40					0	0	0.00074312	0	0
CFHR1	3078	broad.mit.edu	37	1	196799639	196799639	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:196799639G>A	uc001gtn.2	+	5	731	c.617G>A	c.(616-618)GGA>GAA	p.G206E	CFHR1_uc001gtm.2_Missense_Mutation_p.G110E	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	206	Sushi 4.				complement activation	extracellular space					0						GATTCTACGGGAAAATGTGGG	0.383													46	48					0	0	0.000781405	0	0
CFHR4	10877	broad.mit.edu	37	1	196884113	196884114	+	Missense_Mutation	DNP	CA	TC	TC			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:196884113_196884114CA>TC	uc001gto.2	+	5	713_714	c.644_645CA>TC	c.(643-645)CCA>CTC	p.P215L	CFHR4_uc009wyy.2_Missense_Mutation_p.P461L|CFHR4_uc001gtp.2_Missense_Mutation_p.P462L	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	215	Sushi 4.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GGGCCTCCTCCACCTATTAGCA	0.371													22	55					0	0	6.4e-05	0	0
CFHR2	3080	broad.mit.edu	37	1	196928157	196928157	+	Nonsense_Mutation	SNP	C	T	T	rs41313888		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:196928157C>T	uc001gtq.1	+	5	837	c.760C>T	c.(760-762)CGA>TGA	p.R254*	CFHR2_uc001gtr.1_Nonsense_Mutation_p.R130*	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	254	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						TCATTCATTTCGAGCAATGTG	0.323													26	56					0	0	0.000878237	0	0
CRB1	23418	broad.mit.edu	37	1	197390429	197390429	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:197390429G>A	uc001gtz.2	+	6	1606	c.1471G>A	c.(1471-1473)GAT>AAT	p.D491N	CRB1_uc010poz.1_Missense_Mutation_p.D422N|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.D379N|CRB1_uc010ppb.1_Missense_Mutation_p.D491N|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Missense_Mutation_p.D140N	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	491	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ATTTGAGGGCGATGGCTTCCT	0.517													21	40					0	0	0.00121646	0	0
NEK7	140609	broad.mit.edu	37	1	198247118	198247118	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:198247118C>T	uc001gun.3	+	6	727	c.400C>T	c.(400-402)CCT>TCT	p.P134S		NM_133494	NP_598001	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	134	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|lung(1)|ovary(1)	4						GAGGCTAATTCCTGAAAGAAC	0.318													37	94					0	0	0.000953801	0	0
PTPN7	5778	broad.mit.edu	37	1	202121710	202121710	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:202121710C>T	uc001gxm.1	-	8	966	c.835G>A	c.(835-837)GAG>AAG	p.E279K	PTPN7_uc001gxl.1_Missense_Mutation_p.E318K|PTPN7_uc001gxn.1_Missense_Mutation_p.E279K|PTPN7_uc010ppv.1_Missense_Mutation_p.E98K|PTPN7_uc010ppw.1_Missense_Mutation_p.E227K|PTPN7_uc010ppx.1_Missense_Mutation_p.E353K|PTPN7_uc010ppy.1_RNA|PTPN7_uc001gxo.1_Missense_Mutation_p.E231K	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type	279	Tyrosine-protein phosphatase.					cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1						GCGGCTGTCTCCGGGCTCTCC	0.657													8	16					0	0	0.000274275	0	0
SYT2	127833	broad.mit.edu	37	1	202566040	202566040	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:202566040C>T	uc001gye.2	-	9	1298	c.1105G>A	c.(1105-1107)GAA>AAA	p.E369K	SYT2_uc010pqb.1_Missense_Mutation_p.E369K|SYT2_uc009xaf.2_Missense_Mutation_p.E199K	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	369	Phospholipid binding (By similarity).|C2 2.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	CCTATGGCTTCGTTCTTGCCC	0.607													19	47					0	0	0.00152264	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204197962	204197962	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:204197962G>A	uc001hau.2	-	20	3096	c.2779C>T	c.(2779-2781)CCT>TCT	p.P927S		NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	927										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TACCGTTCAGGGATGAGGACT	0.567													13	43					0	0	0.00185496	0	0
NFASC	23114	broad.mit.edu	37	1	204945813	204945813	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:204945813A>T	uc001hbj.2	+	16	2049	c.1721A>T	c.(1720-1722)GAC>GTC	p.D574V	NFASC_uc001hbh.2_Missense_Mutation_p.D574V|NFASC_uc010pqz.1_Missense_Mutation_p.D568V|NFASC_uc010pra.1_Missense_Mutation_p.D585V|NFASC_uc001hbi.2_Missense_Mutation_p.D585V|NFASC_uc010prb.1_Missense_Mutation_p.D585V|NFASC_uc010prc.1_Missense_Mutation_p.D141V|NFASC_uc001hbk.1_Missense_Mutation_p.D395V	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	574	Extracellular (Potential).|Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAGAAGGAAGACGACTCCCTG	0.602													41	119					0	0	0.00170553	0	0
PM20D1	148811	broad.mit.edu	37	1	205811876	205811876	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:205811876C>T	uc001hdj.2	-	7	876	c.831G>A	c.(829-831)TTG>TTA	p.L277L	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	277						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GTGTCTGCTCCAATCTGGAAG	0.473													26	66					0	0	0.00047179	0	0
SLC26A9	115019	broad.mit.edu	37	1	205899142	205899142	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:205899142G>A	uc001hdq.2	-	6	709	c.595C>T	c.(595-597)CTC>TTC	p.L199F	SLC26A9_uc001hdo.2_5'Flank|SLC26A9_uc001hdp.2_Missense_Mutation_p.L199F	NM_052934	NP_443166	Q7LBE3	S26A9_HUMAN	solute carrier family 26, member 9 isoform a	199	Helical; (Potential).					integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			ovary(1)|skin(1)	2	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GACTCGGAGAGGTAGATGGCC	0.562													8	30					0	0	0.000274275	0	0
SRGAP2	23380	broad.mit.edu	37	1	206628240	206628240	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:206628240G>A	uc001hdy.2	+	18	2449	c.2116G>A	c.(2116-2118)GAG>AAG	p.E706K	SRGAP2_uc001hdx.2_Missense_Mutation_p.E706K|SRGAP2_uc010pru.1_Missense_Mutation_p.E629K	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	793					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					CGGTGTCGTGGAGAGGTCCAG	0.587													14	44					0	0	0.000308642	0	0
CENPF	1063	broad.mit.edu	37	1	214819674	214819674	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:214819674C>T	uc001hkm.2	+	13	6935	c.6761C>T	c.(6760-6762)TCT>TTT	p.S2254F		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2350	Potential.|2-1.|2 X 177 AA tandem repeats.|Interaction with NDE1 and NDEL1.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAAGAAGAATCTAAAACTGCA	0.398													35	127					0	0	0.00111076	0	0
USH2A	7399	broad.mit.edu	37	1	216496976	216496976	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:216496976G>A	uc001hku.1	-	8	1777	c.1390C>T	c.(1390-1392)CGT>TGT	p.R464C	USH2A_uc001hkv.2_Missense_Mutation_p.R464C	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	464	Laminin N-terminal.|Extracellular (Potential).		R -> C (in USH2A; uncertain pathogenicity).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TATCCAGGACGATAATTTGGT	0.373										HNSCC(13;0.011)			40	95					0	0	0.000509022	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220340851	220340852	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:220340851_220340852GG>AA	uc010puk.1	-	25	3136_3137	c.2972_2973CC>TT	c.(2971-2973)GCC>GTT	p.A991V	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.A571V|RAB3GAP2_uc001hmh.2_5'Flank	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	991					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CACCTGGTATGGCTCCTAAGTC	0.381													48	115					0	0	6.4e-05	0	0
DISP1	84976	broad.mit.edu	37	1	223176933	223176934	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:223176933_223176934GG>TT	uc001hnu.1	+	8	2341_2342	c.2194_2195GG>TT	c.(2194-2196)GGG>TTG	p.G732L		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	732	Helical; (Potential).				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AACTGTAGGTGGGGCCTACATT	0.426													13	672					0	0	6.4e-05	0	0
EPHX1	2052	broad.mit.edu	37	1	226019641	226019641	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:226019641C>T	uc001hpk.2	+	3	425	c.345C>T	c.(343-345)CAC>CAT	p.H115H	EPHX1_uc001hpl.2_Silent_p.H115H	NM_001136018	NP_001129490	P07099	HYEP_HUMAN	epoxide hydrolase 1	115					aromatic compound catabolic process|response to toxin	endoplasmic reticulum membrane|integral to membrane|microsome	cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity			ovary(3)|lung(1)	4	Breast(184;0.197)					GATACCCTCACTTCAAGACTA	0.438													17	49					0	0	0.00152264	0	0
KIAA1383	54627	broad.mit.edu	37	1	232942697	232942697	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:232942697A>G	uc001hvh.2	+	1	2060	c.1928A>G	c.(1927-1929)AAT>AGT	p.N643S		NM_019090	NP_061963	Q9P2G4	K1383_HUMAN	hypothetical protein LOC54627	501										ovary(1)	1		all_cancers(173;0.00528)|Prostate(94;0.122)|all_epithelial(177;0.169)				GGCTTAACAAATACACTAAGA	0.343													16	32					0	0	0.000566183	0	0
KIAA1804	84451	broad.mit.edu	37	1	233512253	233512253	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:233512253C>T	uc001hvt.3	+	8	2165	c.1904C>T	c.(1903-1905)TCA>TTA	p.S635L	KIAA1804_uc001hvu.3_Missense_Mutation_p.S81L	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	635					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				CCCTTGGCTTCATTGTTTGTG	0.413													11	34					0	0	0.00185496	0	0
KIAA1804	84451	broad.mit.edu	37	1	233515355	233515355	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:233515355C>T	uc001hvt.3	+	9	2864	c.2603C>T	c.(2602-2604)TCC>TTC	p.S868F	KIAA1804_uc001hvu.3_Missense_Mutation_p.S314F	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	868					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				TTGCCGTCTTCCTTCCTACAG	0.498													19	40					0	0	0.000958276	0	0
KCNK1	3775	broad.mit.edu	37	1	233802528	233802528	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:233802528C>T	uc010pxo.1	+	2	711	c.543C>T	c.(541-543)ATC>ATT	p.I181I	KCNK1_uc001hvw.2_RNA|KCNK1_uc001hvx.2_RNA	NM_002245	NP_002236	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	181	Helical; (Potential).					voltage-gated potassium channel complex	inward rectifier potassium channel activity			central_nervous_system(1)	1		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	TGGTGGCCATCGTCCATGCCG	0.602													22	58					0	0	0.00188189	0	0
MTR	4548	broad.mit.edu	37	1	236979789	236979789	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:236979789C>T	uc001hyi.3	+	8	1133	c.710C>T	c.(709-711)TCC>TTC	p.S237F	MTR_uc010pxv.1_RNA|MTR_uc010pxw.1_5'UTR|MTR_uc010pxx.1_Missense_Mutation_p.S237F|MTR_uc010pxy.1_Missense_Mutation_p.S237F|MTR_uc009xgj.1_Missense_Mutation_p.P68S	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	237	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CGGACTCTTTCCGGACAGACA	0.408													126	116					0	0	0.000781405	0	0
ZP4	57829	broad.mit.edu	37	1	238050115	238050115	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:238050115C>T	uc001hym.2	-	6	795	c.795G>A	c.(793-795)GTG>GTA	p.V265V	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	265	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCCCATTTTTCACATCCCTAG	0.468													34	97					0	0	0.000814825	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090420	238090420	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:238090420C>T	uc010pyc.1	+	12		c.1926C>T				NR_027247				Homo sapiens mRNA; cDNA DKFZp434B2115 (from clone DKFZp434B2115).												0						TGTGCGTGGCCCTGGAGGAGC	0.567													8	25					0	0	0.000274275	0	0
FMN2	56776	broad.mit.edu	37	1	240351539	240351539	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:240351539A>T	uc010pyd.1	+	4	2188	c.1963A>T	c.(1963-1965)AAA>TAA	p.K655*	FMN2_uc010pye.1_Nonsense_Mutation_p.K659*	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	655					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AACTCCCCAAAAACGCTCAGA	0.373													17	71					0	0	0.000958276	0	0
KIF26B	55083	broad.mit.edu	37	1	245775268	245775268	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:245775268G>A	uc001ibf.1	+	9	2528	c.2088G>A	c.(2086-2088)GGG>GGA	p.G696G	KIF26B_uc010pyq.1_Silent_p.G696G|KIF26B_uc001ibg.1_Silent_p.G314G	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	696	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGAAGAGCGGGAAAGGGGGAA	0.557													11	39					0	0	0.00185496	0	0
C1orf150	148823	broad.mit.edu	37	1	247737496	247737496	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:247737496C>T	uc001idf.2	+	5	265	c.220C>T	c.(220-222)CAC>TAC	p.H74Y	C1orf150_uc009xgw.2_RNA|C1orf150_uc001ida.3_RNA|C1orf150_uc001idb.3_RNA|C1orf150_uc009xgx.2_RNA	NM_145278	NP_660321	Q5JQS6	CA150_HUMAN	hypothetical protein LOC148823	74											0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TGTCATTAATCACATCCCCCA	0.443													32	96					0	0	0.00178596	0	0
OR2G2	81470	broad.mit.edu	37	1	247752385	247752385	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:247752385G>A	uc010pyy.1	+	1	724	c.724G>A	c.(724-726)GGG>AGG	p.G242R		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GAAAGCATTCGGGACCTGCTT	0.403													32	52					0	0	0.00178596	0	0
OR2G2	81470	broad.mit.edu	37	1	247752599	247752599	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:247752599G>A	uc010pyy.1	+	1	938	c.938G>A	c.(937-939)GGA>GAA	p.G313E		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AAGGCTCTGGGAGtaaatatt	0.313													27	87					0	0	0.000878237	0	0
OR2L1P	26247	broad.mit.edu	37	1	248154185	248154185	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:248154185C>T	uc001idv.1	+	1	617	c.373C>T	c.(373-375)CTT>TTT	p.L125F	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						CACCATTTTTCTTGTGTTTCC	0.468													18	59					0	0	0.00074312	0	0
OR2M2	391194	broad.mit.edu	37	1	248343365	248343365	+	Silent	SNP	C	T	T	rs149789397		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:248343365C>T	uc010pzf.1	+	1	78	c.78C>T	c.(76-78)TTC>TTT	p.F26F		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F26F(1)		ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CACACACGTTCCTCTTCTTTC	0.493													69	181					0	0	0.000781405	0	0
OR2M3	127062	broad.mit.edu	37	1	248366832	248366832	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:248366832G>A	uc010pzg.1	+	1	463	c.463G>A	c.(463-465)GAT>AAT	p.D155N		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGGCTCTACGGATGGAATTAT	0.473													57	154					0	0	0.000781405	0	0
OR2T4	127074	broad.mit.edu	37	1	248525185	248525185	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:248525185G>A	uc001ieh.1	+	1	303	c.303G>A	c.(301-303)ATG>ATA	p.M101I		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	101	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTCTCTCATGGACATGGCGT	0.502													63	216					0	0	0.000781405	0	0
OR2T4	127074	broad.mit.edu	37	1	248525707	248525707	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:248525707C>T	uc001ieh.1	+	1	825	c.825C>T	c.(823-825)TCC>TCT	p.S275S		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	275	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTCCTCCCACCTGACTG	0.537													41	116					0	0	0.000509022	0	0
OR2T3	343173	broad.mit.edu	37	1	248637593	248637593	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:248637593G>A	uc001iel.1	+	1	942	c.942G>A	c.(940-942)ATG>ATA	p.M314I		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	314	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGTCAAGAATGAACCAAGAAA	0.488													37	304					0	0	0.00170553	0	0
ITIH2	3698	broad.mit.edu	37	10	7751130	7751130	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:7751130G>A	uc001ijs.2	+	4	500	c.338G>A	c.(337-339)GGA>GAA	p.G113E		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	113	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						ATCCCCAAAGGAGCATTCATT	0.393													19	21					0	0	0.000375601	0	0
KIN	22944	broad.mit.edu	37	10	7817756	7817756	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:7817756G>A	uc001ijt.2	-	6	613	c.565C>T	c.(565-567)CCT>TCT	p.P189S	KIN_uc010qaz.1_RNA|KIN_uc009xip.2_Missense_Mutation_p.P189S|KIN_uc010qba.1_Missense_Mutation_p.P83S	NM_012311	NP_036443	O60870	KIN17_HUMAN	HsKin17 protein	189					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GTAAAAGTAGGGACCTCCTAA	0.308													12	7					0	0	0.000978159	0	0
PHYH	5264	broad.mit.edu	37	10	13323103	13323103	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:13323103G>A	uc001imf.2	-	8	924	c.836C>T	c.(835-837)TCC>TTC	p.S279F	PHYH_uc001ime.2_Missense_Mutation_p.S179F|PHYH_uc001img.2_Missense_Mutation_p.S262F	NM_006214	NP_006205	O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase isoform a precursor	279					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding				0		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	GAAATGGCAGGAAATTGCCTG	0.403													21	11					0	0	0.00121646	0	0
BEND7	222389	broad.mit.edu	37	10	13522979	13522979	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:13522979G>A	uc001imm.2	-	6	1124	c.827C>T	c.(826-828)TCC>TTC	p.S276F	BEND7_uc001imn.2_Missense_Mutation_p.S37F|BEND7_uc001imo.3_Missense_Mutation_p.S289F	NM_152751	NP_689964	Q8N7W2	BEND7_HUMAN	BEN domain containing 7 isoform 1	328	BEN.						protein binding			ovary(1)|breast(1)	2						ATTGGGTAAGGAGTTAGCCAA	0.423													44	20					0	0	0.000680045	0	0
PLXDC2	84898	broad.mit.edu	37	10	20436730	20436730	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:20436730C>T	uc001iqg.1	+	6	1319	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	PLXDC2_uc001iqh.1_Nonsense_Mutation_p.Q179*|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	228	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						ACTTGTGGTCCAGTGGGACCA	0.408													25	11					0	0	0.000586117	0	0
KIAA1217	56243	broad.mit.edu	37	10	24762301	24762301	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:24762301C>T	uc001iru.3	+	6	1394	c.991C>T	c.(991-993)CCT>TCT	p.P331S	KIAA1217_uc001irs.2_Missense_Mutation_p.P251S|KIAA1217_uc001irt.3_Missense_Mutation_p.P331S|KIAA1217_uc010qcy.1_Missense_Mutation_p.P331S|KIAA1217_uc010qcz.1_Missense_Mutation_p.P331S|KIAA1217_uc001irv.1_Missense_Mutation_p.P181S|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.P49S|KIAA1217_uc001irz.2_Missense_Mutation_p.P49S|KIAA1217_uc001irx.2_Missense_Mutation_p.P49S|KIAA1217_uc001iry.2_Missense_Mutation_p.P49S	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	331	Pro-rich.				embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GTCCAGAATTCCTTATGGGGG	0.612													16	8					0	0	0.000308642	0	0
ARMC4	55130	broad.mit.edu	37	10	28224181	28224181	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:28224181C>T	uc009xky.2	-	16	2351	c.2253G>A	c.(2251-2253)AAG>AAA	p.K751K	ARMC4_uc010qds.1_Silent_p.K276K|ARMC4_uc010qdt.1_Silent_p.K443K|ARMC4_uc001itz.2_Silent_p.K751K	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	751	ARM 5.						binding			ovary(4)|skin(2)	6						ATTCCCGAAACCTAAGTTCAT	0.333													25	15					0	0	0.000586117	0	0
KIAA1462	57608	broad.mit.edu	37	10	30336727	30336727	+	Missense_Mutation	SNP	T	A	A	rs112079947	by1000genomes	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:30336727T>A	uc001iux.2	-	1	74	c.15A>T	c.(13-15)GAA>GAT	p.E5D	KIAA1462_uc001iuy.2_Missense_Mutation_p.E5D|KIAA1462_uc001iuz.2_Translation_Start_Site|KIAA1462_uc009xle.1_Missense_Mutation_p.E5D	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	5										ovary(4)	4						TCAGGAGGTCTTCTACACTGT	0.567													28	16					0	0	0.001512	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453													3	55					0	0	6.4e-05	0	0
ASAH2	56624	broad.mit.edu	37	10	51974589	51974589	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:51974589C>T	uc001jjd.2	-	8	1054	c.1054G>A	c.(1054-1056)GAT>AAT	p.D352N	ASAH2_uc009xos.2_Missense_Mutation_p.D352N	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	352	Lumenal (Potential).			D->A: Abolishes enzyme activity.	apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						GGGGACACATCTCCTAGGTTT	0.448													18	26					0	0	0.00121646	0	0
ANK3	288	broad.mit.edu	37	10	61832232	61832232	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:61832232C>T	uc001jky.2	-	37	8599	c.8407G>A	c.(8407-8409)GAT>AAT	p.D2803N	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2803					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GAGCCAGAATCATTTACAACA	0.388													25	21					0	0	0.000586117	0	0
TMEM26	219623	broad.mit.edu	37	10	63170154	63170154	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:63170154C>T	uc001jlo.2	-	6	1402	c.1033G>A	c.(1033-1035)GAG>AAG	p.E345K	TMEM26_uc010qij.1_RNA|TMEM26_uc001jlp.1_RNA	NM_178505	NP_848600	Q6ZUK4	TMM26_HUMAN	transmembrane protein 26	345						integral to membrane					0	Prostate(12;0.0112)					TCCTTAGACTCGTTCTGCCAG	0.587													16	13					0	0	0.000422831	0	0
CCAR1	55749	broad.mit.edu	37	10	70514543	70514543	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:70514543G>A	uc001joo.2	+	12	1536	c.1417G>A	c.(1417-1419)GAA>AAA	p.E473K	CCAR1_uc001jol.1_RNA|CCAR1_uc001jom.1_Missense_Mutation_p.E278K|CCAR1_uc009xpx.1_Missense_Mutation_p.E447K|CCAR1_uc001jon.1_Missense_Mutation_p.E419K|CCAR1_uc010qiz.1_Missense_Mutation_p.E458K|CCAR1_uc010qja.1_Missense_Mutation_p.E458K|CCAR1_uc010qjb.1_RNA|SNORD98_uc001jop.1_5'Flank	NM_018237	NP_060707	Q8IX12	CCAR1_HUMAN	cell-cycle and apoptosis regulatory protein 1	473					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			ovary(6)|large_intestine(1)	7						GGACCCACAAGAACTTCGAGA	0.368													38	14					0	0	0.00195071	0	0
CDH23	64072	broad.mit.edu	37	10	73462447	73462447	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:73462447A>T	uc001jrx.3	+	23	3106	c.2729A>T	c.(2728-2730)TAC>TTC	p.Y910F	CDH23_uc001jry.2_Missense_Mutation_p.Y526F|CDH23_uc001jrz.2_Missense_Mutation_p.Y526F	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	910	Cadherin 9.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GTCTCCATCTACCAAGTGAGT	0.562													24	11					0	0	0.000586117	0	0
CCDC109A	90550	broad.mit.edu	37	10	74619034	74619034	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:74619034C>T	uc001jtc.2	+	3	341	c.320C>T	c.(319-321)TCT>TTT	p.S107F	CCDC109A_uc009xqp.1_RNA|CCDC109A_uc009xqq.1_RNA|CCDC109A_uc010qjy.1_RNA|CCDC109A_uc009xqr.2_Missense_Mutation_p.S107F|CCDC109A_uc001jtd.2_Missense_Mutation_p.S58F	NM_138357	NP_612366	Q8NE86	MCU_HUMAN	coiled-coil domain containing 109A	107	Mitochondrial matrix (Potential).			S -> P (in Ref. 1; BAG37900).	elevation of mitochondrial calcium ion concentration|mitochondrial calcium ion transport|protein complex oligomerization	integral to membrane|mitochondrial inner membrane	protein binding				0	Prostate(51;0.0198)					ATCTCTGACTCTGTTGGTGTA	0.428													27	25					0	0	0.00127121	0	0
SEC24C	9632	broad.mit.edu	37	10	75527676	75527676	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:75527676C>T	uc001juw.2	+	16	2271	c.2092C>T	c.(2092-2094)CTC>TTC	p.L698F	SEC24C_uc009xrj.1_Missense_Mutation_p.L556F|SEC24C_uc001jux.2_Missense_Mutation_p.L698F|SEC24C_uc010qko.1_Missense_Mutation_p.L579F|SEC24C_uc010qkp.1_Intron|SEC24C_uc010qkq.1_Intron	NM_004922	NP_004913	P53992	SC24C_HUMAN	SEC24-related protein C	698					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			skin(2)|central_nervous_system(1)	3	Prostate(51;0.0112)					AGATCTCTTTCTCTTCCCTAA	0.522													23	9					0	0	0.00229938	0	0
SFTPD	6441	broad.mit.edu	37	10	81701826	81701826	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:81701826C>T	uc001kbh.2	-	5	477	c.434G>A	c.(433-435)GGA>GAA	p.G145E	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	145	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			ACCTACTTCTCCTGAAGAAGG	0.577													22	17					0	0	0.000586117	0	0
SH2D4B	387694	broad.mit.edu	37	10	82331323	82331323	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:82331323G>A	uc001kck.1	+	3	914	c.484G>A	c.(484-486)GAG>AAG	p.E162K	SH2D4B_uc001kcl.1_Missense_Mutation_p.E113K	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	161	Glu-rich.										0			Colorectal(32;0.229)			ACGCATCCACGAGGAATTCAA	0.592													10	10					0	0	0.00185496	0	0
LIPF	8513	broad.mit.edu	37	10	90438385	90438385	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:90438385C>T	uc001kfg.1	+	10	1310	c.1144C>T	c.(1144-1146)CCT>TCT	p.P382S	LIPF_uc001kfh.1_Missense_Mutation_p.P359S|LIPF_uc010qmt.1_Missense_Mutation_p.P392S|LIPF_uc010qmu.1_Missense_Mutation_p.P349S	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	382					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		AATGGATGCCCCTCAAGAAGT	0.343													32	19					0	0	0.00209593	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90733018	90733018	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:90733018G>A	uc010qmx.1	+	11	1757	c.1334G>A	c.(1333-1335)GGA>GAA	p.G445E	ACTA2_uc001kfq.2_Intron|FAS_uc010qna.1_RNA	NM_020799	NP_065850	Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	Error:Variant_position_missing_in_Q96FJ0_after_alignment							metal ion binding|metallopeptidase activity|protein binding			ovary(1)	1		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		GGACCAAATGGATTCCCACTC	0.433													26	18					0	0	0.000586117	0	0
PPP1R3C	5507	broad.mit.edu	37	10	93389689	93389689	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:93389689G>A	uc001kho.2	-	2	1081	c.949C>T	c.(949-951)CGA>TGA	p.R317*		NM_005398	NP_005389	Q9UQK1	PPR3C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	317							protein serine/threonine phosphatase activity			breast(1)	1		Colorectal(252;0.235)				TTAATTCATCGATAAGAGGCC	0.473													33	14					0	0	0.00058488	0	0
EXOC6	54536	broad.mit.edu	37	10	94594495	94594495	+	Silent	SNP	G	A	A	rs77134517	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:94594495G>A	uc010qnr.1	+	2	206	c.63G>A	c.(61-63)GCG>GCA	p.A21A	EXOC6_uc001kie.2_5'UTR	NM_001013848	NP_001013870	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform b	Error:Variant_position_missing_in_Q8TAG9_after_alignment					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				CCTGTCGAGCGATGTTGGAAG	0.383													104	50					0	0	0.000781405	0	0
PDE6C	5146	broad.mit.edu	37	10	95372779	95372779	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:95372779C>T	uc001kiu.3	+	1	435	c.297C>T	c.(295-297)TTC>TTT	p.F99F		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	99	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				GCAGCATGTTCCTGTGCCGGT	0.652													17	12					0	0	0.000566183	0	0
CYP2C18	1562	broad.mit.edu	37	10	96480239	96480239	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:96480239G>A	uc001kjv.3	+	6	1232	c.906G>A	c.(904-906)ACG>ACA	p.T302T	CYP2C18_uc001kjw.3_Silent_p.T243T|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	302					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		CAGAGACAACGAGCACCACTC	0.423													25	19					0	0	0.00106085	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97388165	97388166	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:97388165_97388166CC>TT	uc001kkz.2	-	8	1134_1135	c.892_893GG>AA	c.(892-894)GGA>AAA	p.G298K	ALDH18A1_uc001kky.2_Missense_Mutation_p.G296K|ALDH18A1_uc010qog.1_Missense_Mutation_p.G187K|ALDH18A1_uc010qoh.1_Missense_Mutation_p.G86K	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	298	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	AGACTTGGTTCCAAATGTCACA	0.416													50	48					0	0	6.4e-05	0	0
ENTPD1	953	broad.mit.edu	37	10	97607239	97607239	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:97607239C>T	uc001klh.3	+	7	1174	c.850C>T	c.(850-852)CAT>TAT	p.H284Y	ENTPD1_uc001kli.3_Missense_Mutation_p.H291Y|uc001klg.1_RNA|ENTPD1_uc010qoj.1_Missense_Mutation_p.H296Y|ENTPD1_uc010qok.1_Missense_Mutation_p.H176Y|ENTPD1_uc010qol.1_Missense_Mutation_p.H176Y|ENTPD1_uc010qom.1_Intron|ENTPD1_uc010qon.1_Missense_Mutation_p.H146Y|ENTPD1_uc009xva.2_Missense_Mutation_p.H146Y|ENTPD1_uc009xuz.2_Intron	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	284	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		CCCATGCTTTCATCCTGGATA	0.418													37	20					0	0	0.000509022	0	0
TACC2	10579	broad.mit.edu	37	10	123844662	123844662	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:123844662G>A	uc001lfv.2	+	4	3007	c.2647G>A	c.(2647-2649)GAA>AAA	p.E883K	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.E883K|TACC2_uc010qtv.1_Missense_Mutation_p.E883K	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	883						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGAACCTCAGGAAGATAACAA	0.502													15	14					0	0	0.000308642	0	0
CYP2E1	1571	broad.mit.edu	37	10	135350654	135350654	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr10:135350654C>T	uc001lnj.1	+	7	1088	c.1055C>T	c.(1054-1056)GCT>GTT	p.A352V	CYP2E1_uc001lnk.1_Missense_Mutation_p.A215V|CYP2E1_uc009ybl.1_Missense_Mutation_p.A153V|CYP2E1_uc009ybm.1_Missense_Mutation_p.A6V|CYP2E1_uc001lnl.1_Missense_Mutation_p.A153V	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	352					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	TACATGGATGCTGTGGTGCAT	0.527									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				19	24					0	0	0.000958276	0	0
NUP98	4928	broad.mit.edu	37	11	3723693	3723693	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:3723693G>T	uc001lyh.2	-	23	3803	c.3512C>A	c.(3511-3513)CCC>CAC	p.P1171H	NUP98_uc001lyi.2_Missense_Mutation_p.P1171H|NUP98_uc001lyg.2_Intron	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1188					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TGTGACTCACGGTTTAACAGC	0.403			T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								5	63					0.00198382	0.00813015	0.00198382	1	0
OR51S1	119692	broad.mit.edu	37	11	4869718	4869718	+	Missense_Mutation	SNP	G	A	A	rs115882083	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:4869718G>A	uc010qyo.1	-	1	721	c.721C>T	c.(721-723)CGC>TGC	p.R241C		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	241	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCTTCCAGCGATCCTCTCTG	0.522													17	9					0	0	0.000566183	0	0
OR51A2	401667	broad.mit.edu	37	11	4976637	4976637	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:4976637C>T	uc010qyt.1	-	1	307	c.307G>A	c.(307-309)GAA>AAA	p.E103K		NM_001004748	NP_001004748	Q8NGJ7	O51A2_HUMAN	olfactory receptor, family 51, subfamily A,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGAAGAATTCCTGGGCAAAG	0.448													56	26					0	0	0.000781405	0	0
OR51L1	119682	broad.mit.edu	37	11	5021068	5021068	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:5021068C>T	uc010qyu.1	+	1	856	c.856C>T	c.(856-858)CCC>TCC	p.P286S		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P286P(1)		skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTTCTTCTTCCCCCAGTCCT	0.458													28	10					0	0	0.00209593	0	0
OR52E4	390081	broad.mit.edu	37	11	5906158	5906158	+	Silent	SNP	G	A	A	rs145588560		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:5906158G>A	uc010qzs.1	+	1	636	c.636G>A	c.(634-636)GTG>GTA	p.V212V	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGTGGATGTGATCTTAATTG	0.453													26	19					0	0	0.00148497	0	0
OR52B2	255725	broad.mit.edu	37	11	6191292	6191292	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:6191292G>A	uc010qzy.1	-	1	265	c.265C>T	c.(265-267)CTT>TTT	p.L89F		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGCTTGAAGCCAAAAGATG	0.493													49	41					0	0	0.000781405	0	0
OR5P2	120065	broad.mit.edu	37	11	7818388	7818388	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:7818388G>A	uc001mfp.1	-	1	102	c.102C>T	c.(100-102)ATC>ATT	p.I34I		NM_153444	NP_703145	Q8WZ92	OR5P2_HUMAN	olfactory receptor, family 5, subfamily P,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TACCAGATAGGATGATCATGA	0.433													22	7					0	0	0.00188189	0	0
SOX6	55553	broad.mit.edu	37	11	16340070	16340070	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:16340070G>A	uc001mme.2	-	3	439	c.406C>T	c.(406-408)CGC>TGC	p.R136C	SOX6_uc001mmd.2_Missense_Mutation_p.R126C|SOX6_uc001mmf.2_Missense_Mutation_p.R123C|SOX6_uc001mmg.2_Missense_Mutation_p.R123C|SOX6_uc001mmh.1_RNA|SOX6_uc009ygs.2_RNA|SOX6_uc001mmi.3_Missense_Mutation_p.R123C|SOX6_uc001mmj.2_Missense_Mutation_p.R123C	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	123					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						CTCCCTTTGCGGCGCTCTGGG	0.498													67	35					0	0	0.000781405	0	0
NAV2	89797	broad.mit.edu	37	11	19955420	19955420	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:19955420C>T	uc010rdm.1	+	8	2060	c.1699C>T	c.(1699-1701)CCC>TCC	p.P567S	NAV2_uc001mpp.2_Missense_Mutation_p.P480S|NAV2_uc001mpr.3_Missense_Mutation_p.P544S	NM_145117	NP_660093	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 2	567						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CAGCTTCATCCCCAAAGGGGG	0.562													25	8					0	0	0.00127121	0	0
QSER1	79832	broad.mit.edu	37	11	32995058	32995058	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:32995058C>T	uc001mty.2	+	11	5201	c.4934C>T	c.(4933-4935)ACT>ATT	p.T1645I	QSER1_uc001mtz.1_Missense_Mutation_p.T1406I|QSER1_uc001mua.2_Missense_Mutation_p.T1150I	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1645										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					AATAAGAAAACTCTAAGGACT	0.303													28	35					0	0	0.0024448	0	0
AGBL2	79841	broad.mit.edu	37	11	47736196	47736196	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:47736196G>T	uc001ngg.2	-	1	107	c.7C>A	c.(7-9)CCA>ACA	p.P3T	AGBL2_uc010rhq.1_Missense_Mutation_p.P3T|AGBL2_uc001ngh.1_Missense_Mutation_p.P3T	NM_024783	NP_079059	Q5U5Z8	CBPC2_HUMAN	carboxypeptidase 2, cytosolic	3					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2						TCCAAAGCTGGGAACATGTTA	0.463													66	50					5.61366e-43	2.35113e-42	0.000781405	1	0
OR9I1	219954	broad.mit.edu	37	11	57886273	57886273	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:57886273A>G	uc001nml.1	-	1	644	c.644T>C	c.(643-645)CTG>CCG	p.L215P	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				ATAGGAAATCAGGATGACGGA	0.478													8	9					0	0	0.000157383	0	0
OR5B12	390191	broad.mit.edu	37	11	58207395	58207395	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:58207395G>A	uc010rkh.1	-	1	230	c.230C>T	c.(229-231)CCC>CTC	p.P77L		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	77	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CATCACCTTGGGAGTGACAGC	0.438													13	5					0	0	0.000219431	0	0
GLYATL2	219970	broad.mit.edu	37	11	58604849	58604849	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:58604849G>A	uc001nnd.3	-	4	339	c.208C>T	c.(208-210)CAT>TAT	p.H70Y	GLYATL2_uc009ymq.2_Missense_Mutation_p.H70Y	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	70						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TTGGTATAATGATCCTGGTCA	0.373													28	17					0	0	0.001512	0	0
CD6	923	broad.mit.edu	37	11	60785429	60785429	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:60785429C>T	uc001nqq.2	+	11	2004	c.1781C>T	c.(1780-1782)TCC>TTC	p.S594F	CD6_uc001nqp.2_Missense_Mutation_p.S594F|CD6_uc001nqr.2_Missense_Mutation_p.S562F|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.S553F	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	594	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						GAGAGGAGTTCCTTCCTGGAG	0.577													20	13					0	0	0.00188189	0	0
AHNAK	79026	broad.mit.edu	37	11	62300683	62300683	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:62300683G>A	uc001ntl.2	-	5	1506	c.1206C>T	c.(1204-1206)CCC>CCT	p.P402P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	402					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCCCAATTTGGGGAGCAGAGG	0.577													15	6					0	0	0.000308642	0	0
WDR74	54663	broad.mit.edu	37	11	62603256	62603256	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:62603256G>A	uc001nvm.1	-	6	595	c.427C>T	c.(427-429)CCC>TCC	p.P143S	WDR74_uc001nvk.1_Missense_Mutation_p.P86S|WDR74_uc001nvl.1_Missense_Mutation_p.P143S|WDR74_uc001nvn.1_Missense_Mutation_p.P195S|WDR74_uc009yoi.1_Missense_Mutation_p.P143S|WDR74_uc010rmk.1_Missense_Mutation_p.P143S	NM_018093	NP_060563	Q6RFH5	WDR74_HUMAN	WD repeat domain 74	143	WD 3.					nucleolus				ovary(1)	1						ACCACATGGGGGTGTGCTGGG	0.532													12	3					0	0	0.00185496	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64607732	64607732	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:64607732C>T	uc001obs.3	-	5	441	c.441G>A	c.(439-441)GTG>GTA	p.V147V		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	147	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						AGTAGTCCATCACAAGGTACT	0.652													8	7					0	0	0.000157383	0	0
SYVN1	84447	broad.mit.edu	37	11	64900952	64900952	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:64900952G>A	uc001odb.2	-	2	215	c.121C>T	c.(121-123)CCC>TCC	p.P41S	SYVN1_uc001odc.2_Missense_Mutation_p.P41S|SYVN1_uc009yqc.2_Missense_Mutation_p.P41S	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	41	Lumenal (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						GCCATGCTGGGGCTGGACTTG	0.637													19	13					0	0	0.00229938	0	0
PAAF1	80227	broad.mit.edu	37	11	73602227	73602227	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:73602227C>T	uc001ouk.1	+	4	297	c.263C>T	c.(262-264)TCC>TTC	p.S88F	PAAF1_uc001oul.1_Missense_Mutation_p.S71F|PAAF1_uc009ytx.1_RNA|PAAF1_uc001oum.1_Missense_Mutation_p.S71F	NM_025155	NP_079431	Q9BRP4	PAAF1_HUMAN	proteasomal ATPase-associated factor 1	88					interspecies interaction between organisms	proteasome complex	protein binding			ovary(1)|skin(1)	2	Breast(11;7.42e-05)					ACTACTTTTTCCAGAATTCAT	0.284													21	14					0	0	0.00188189	0	0
DCUN1D5	84259	broad.mit.edu	37	11	102937231	102937231	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:102937231G>A	uc001phm.2	-	5	675	c.407C>T	c.(406-408)TCG>TTG	p.S136L	DCUN1D5_uc010ruw.1_Missense_Mutation_p.S67L	NM_032299	NP_115675	Q9BTE7	DCNL5_HUMAN	DCN1, defective in cullin neddylation 1, domain	136	DCUN1.										0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.00032)|Epithelial(105;0.0689)|all cancers(92;0.186)		CTTAAATGACGAAATATCATT	0.303													18	14					0	0	0.00188189	0	0
DDI1	414301	broad.mit.edu	37	11	103908174	103908174	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:103908174G>A	uc001phr.2	+	1	867	c.624G>A	c.(622-624)CGG>CGA	p.R208R	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	208					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CACTGGATCGGGAAGCTCAGG	0.498													42	24					0	0	0.00148497	0	0
HTR3B	9177	broad.mit.edu	37	11	113780017	113780017	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:113780017G>A	uc001pok.2	+	2	120	c.53G>A	c.(52-54)GGA>GAA	p.G18E	HTR3B_uc001pol.2_Missense_Mutation_p.G7E	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	18					synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TATTTTCCAGGAATTCTAGCC	0.388													32	15					0	0	0.0024448	0	0
DSCAML1	57453	broad.mit.edu	37	11	117302311	117302311	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:117302311G>A	uc001prh.1	-	31	5495	c.5493C>T	c.(5491-5493)TCC>TCT	p.S1831S		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1771	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACCATGCTGGGAGCCCACGG	0.647													25	16					0	0	0.000375601	0	0
DSCAML1	57453	broad.mit.edu	37	11	117651308	117651308	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:117651308G>A	uc001prh.1	-	2	446	c.444C>T	c.(442-444)TCC>TCT	p.S148S	DSCAML1_uc001pri.1_5'UTR	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	88	Extracellular (Potential).|Ig-like C2-type 1.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AGGCGGAGGGGGAGAAGGGGT	0.622													54	51					0	0	0.000781405	0	0
MLL	4297	broad.mit.edu	37	11	118373178	118373178	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:118373178C>T	uc001pta.2	+	27	6585	c.6562C>T	c.(6562-6564)CGA>TGA	p.R2188*	MLL_uc001ptb.2_Nonsense_Mutation_p.R2191*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2188					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CTCTGGACTTCGAAGCATTGG	0.448			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								18	15					0	0	0.00121646	0	0
MLL	4297	broad.mit.edu	37	11	118375900	118375900	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:118375900C>T	uc001pta.2	+	27	9307	c.9284C>T	c.(9283-9285)CCA>CTA	p.P3095L	MLL_uc001ptb.2_Missense_Mutation_p.P3098L	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	3095					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAAACTCTTCCAAATGGAGTG	0.473			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								45	23					0	0	0.000781405	0	0
OR4D5	219875	broad.mit.edu	37	11	123810973	123810973	+	Missense_Mutation	SNP	C	T	T	rs138187932		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:123810973C>T	uc001pzk.1	+	1	650	c.650C>T	c.(649-651)TCG>TTG	p.S217L		NM_001001965	NP_001001965	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTTCTGGGATCGTACACAGCA	0.517													67	45					0	0	0.000781405	0	0
OR6T1	219874	broad.mit.edu	37	11	123814360	123814360	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:123814360G>A	uc010sab.1	-	1	186	c.186C>T	c.(184-186)TTC>TTT	p.F62F		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	62	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AATTCCGCAGGAAGAAGTACA	0.488													42	21					0	0	0.000509022	0	0
OR8B2	26595	broad.mit.edu	37	11	124253229	124253229	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr11:124253229C>T	uc010sai.1	-	1	11	c.11G>A	c.(10-12)AGA>AAA	p.R4K	OR8B2_uc001qab.3_RNA	NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	4	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GGAGTTGTTTCTAGCCAGCAT	0.368													19	16					0	0	0.00074312	0	0
LRTM2	654429	broad.mit.edu	37	12	1940342	1940342	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:1940342C>T	uc001qjt.2	+	4	1115	c.309C>T	c.(307-309)TTC>TTT	p.F103F	CACNA2D4_uc001qjp.2_Intron|CACNA2D4_uc009zds.1_Intron|CACNA2D4_uc009zdt.1_Intron|CACNA2D4_uc009zdr.1_Intron|LRTM2_uc001qju.2_Silent_p.F103F|LRTM2_uc010sdx.1_Silent_p.F103F|LRTM2_uc001qjv.2_Intron	NM_001039029	NP_001034118	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	103	LRR 2.|Extracellular (Potential).					integral to membrane				large_intestine(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			CCAACAACTTCCTGGACCGGC	0.592													18	40					0	0	0.00074312	0	0
CACNA1C	775	broad.mit.edu	37	12	2706657	2706657	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:2706657C>T	uc009zdu.1	+	22	3221	c.2908C>T	c.(2908-2910)CTT>TTT	p.L970F	CACNA1C_uc009zdv.1_Intron|CACNA1C_uc001qkb.2_Missense_Mutation_p.L950F|CACNA1C_uc001qkc.2_Missense_Mutation_p.L950F|CACNA1C_uc001qke.2_Missense_Mutation_p.L950F|CACNA1C_uc001qkf.2_Missense_Mutation_p.L950F|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Missense_Mutation_p.L970F|CACNA1C_uc001qkn.2_Missense_Mutation_p.L950F|CACNA1C_uc001qko.2_Missense_Mutation_p.L970F|CACNA1C_uc001qkp.2_Missense_Mutation_p.L950F|CACNA1C_uc001qkr.2_Missense_Mutation_p.L950F|CACNA1C_uc001qku.2_Missense_Mutation_p.L950F|CACNA1C_uc001qkq.2_Intron|CACNA1C_uc001qks.2_Intron|CACNA1C_uc001qkt.2_Intron|CACNA1C_uc001qka.1_Missense_Mutation_p.L485F|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	970	III.|Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGAAATTATCCTTAAGGTAAT	0.403													12	18					0	0	0.000219431	0	0
ITFG2	55846	broad.mit.edu	37	12	2927308	2927308	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:2927308C>T	uc001qlb.1	+	4	335	c.271C>T	c.(271-273)CAT>TAT	p.H91Y	ITFG2_uc001qla.1_Missense_Mutation_p.H91Y|ITFG2_uc010seb.1_Intron|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	91											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			AGGCTGGTTTCATTTGTTTGA	0.517													28	44					0	0	0.00127121	0	0
ANO2	57101	broad.mit.edu	37	12	5915239	5915239	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:5915239C>T	uc001qnm.2	-	9	1029	c.957G>A	c.(955-957)GAG>GAA	p.E319E		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	324	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						TCATATCGTCCTCTGGACTAT	0.473													18	31					0	0	0.00188189	0	0
SCNN1A	6337	broad.mit.edu	37	12	6463605	6463605	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:6463605C>T	uc001qnx.2	-	8	1648	c.1359G>A	c.(1357-1359)TGG>TGA	p.W453*	SCNN1A_uc001qnv.2_Nonsense_Mutation_p.W153*|SCNN1A_uc001qnw.2_Nonsense_Mutation_p.W512*|SCNN1A_uc010sfb.1_Nonsense_Mutation_p.W476*	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	453	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	GAGTCTCACCCCAGGAACTGT	0.572													40	57					0	0	0.000509022	0	0
SCNN1A	6337	broad.mit.edu	37	12	6464564	6464564	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:6464564G>A	uc001qnx.2	-	6	1306	c.1017C>T	c.(1015-1017)TTC>TTT	p.F339F	SCNN1A_uc001qnv.2_Silent_p.F39F|SCNN1A_uc001qnw.2_Silent_p.F398F|SCNN1A_uc010sfb.1_Silent_p.F362F	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	339	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	GCAGGGGAATGAAGTCATTCT	0.572													6	13					0	0	0.00198382	0	0
ATN1	1822	broad.mit.edu	37	12	7043347	7043347	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:7043347G>T	uc001qrw.1	+	3	273	c.36G>T	c.(34-36)ATG>ATT	p.M12I	ATN1_uc001qrx.1_Missense_Mutation_p.M12I|ATN1_uc001qry.1_Missense_Mutation_p.M12I	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	12					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						AGATGTCAATGAGGAGTGGAC	0.537													11	28					4.68919e-08	1.95322e-07	0.000673444	1	0
PTPN6	5777	broad.mit.edu	37	12	7069157	7069157	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:7069157G>A	uc001qsb.2	+	12	1671	c.1429G>A	c.(1429-1431)GGC>AGC	p.G477S	PTPN6_uc001qsa.1_Missense_Mutation_p.G479S|PTPN6_uc010sfr.1_Missense_Mutation_p.G438S|PTPN6_uc009zfl.1_Missense_Mutation_p.G477S|PTPN6_uc010sfs.1_Missense_Mutation_p.G465S	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	477	Tyrosine-protein phosphatase.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						CTCCACCAAGGGTGAGGGGCA	0.657													27	51					0	0	0.00127121	0	0
CLEC4D	338339	broad.mit.edu	37	12	8673834	8673834	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:8673834G>A	uc001qun.2	+	6	808	c.615G>A	c.(613-615)AGG>AGA	p.R205R		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	205	C-type lectin.|Extracellular (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					AAGCAAGTAGGATTTGTAAAA	0.368													34	66					0	0	0.00058488	0	0
CLEC4E	26253	broad.mit.edu	37	12	8687260	8687260	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:8687260G>A	uc001quo.1	-	6	799	c.634C>T	c.(634-636)CCT>TCT	p.P212S		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	212	Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					TTGTTCAAAGGATTTATTCCT	0.418													17	29					0	0	0.000958276	0	0
MFAP5	8076	broad.mit.edu	37	12	8808044	8808044	+	Splice_Site	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:8808044C>A	uc001qut.1	-	5	353	c.140_splice	c.e5-1	p.N47_splice	MFAP5_uc001qus.2_Splice_Site_p.N47_splice|MFAP5_uc009zge.1_Splice_Site_p.N47_splice	NM_003480	NP_003471	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5 precursor							microfibril	extracellular matrix structural constituent			breast(1)	1	Lung SC(5;0.184)					TTCACCAGATCTGCAAAGACA	0.378													12	30					6.31663e-08	2.62906e-07	0.000308642	1	0
A2ML1	144568	broad.mit.edu	37	12	8982357	8982357	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:8982357C>T	uc001quz.3	+	4	542	c.444C>T	c.(442-444)TTC>TTT	p.F148F		NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	Error:Variant_position_missing_in_B3KVV6_after_alignment						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						ATAGCAACTTCGTTCCAGTGA	0.458													43	71					0	0	0.000680045	0	0
A2M	2	broad.mit.edu	37	12	9266120	9266120	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:9266120G>A	uc001qvk.1	-	2	219	c.106C>T	c.(106-108)CCC>TCC	p.P36S	A2M_uc009zgk.1_5'UTR	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	36					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	AGCAGGGAGGGGACCAGAACC	0.493													28	48					0	0	0.000491102	0	0
KLRC3	3823	broad.mit.edu	37	12	10569321	10569321	+	Missense_Mutation	SNP	G	A	A	rs138941727		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:10569321G>A	uc001qyf.2	-	5	577	c.532C>T	c.(532-534)CGT>TGT	p.R178C	KLRC3_uc001qyh.2_Missense_Mutation_p.R178C|KLRC3_uc001qyi.1_Missense_Mutation_p.R178C	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	178	C-type lectin.|Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity	p.R178C(1)		ovary(2)|skin(1)	3						CTGCTGTTACGAAACACACCA	0.294													19	30					0	0	0.00209593	0	0
KLRC1	3821	broad.mit.edu	37	12	10599208	10599208	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:10599208C>T	uc001qyl.2	-	7	808	c.644G>A	c.(643-645)CGA>CAA	p.R215Q	KLRC1_uc009zhm.1_Missense_Mutation_p.R215Q|KLRC1_uc001qym.2_Missense_Mutation_p.R197Q|KLRC1_uc001qyn.2_Missense_Mutation_p.R215Q|KLRC1_uc001qyo.2_Missense_Mutation_p.R197Q	NM_002259	NP_002250	P26715	NKG2A_HUMAN	killer cell lectin-like receptor subfamily C,	215	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						TGATTTAAGTCGATTTACTTG	0.333													31	83					0	0	0.00128727	0	0
TAS2R8	50836	broad.mit.edu	37	12	10959048	10959048	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:10959048G>A	uc010shh.1	-	1	532	c.532C>T	c.(532-534)CCA>TCA	p.P178S		NM_023918	NP_076407	Q9NYW2	TA2R8_HUMAN	taste receptor, type 2, member 8	178	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			ovary(2)	2						TCAAAGTATGGTATTTTACTC	0.338													20	32					0	0	0.00152264	0	0
C12orf69	440087	broad.mit.edu	37	12	14958949	14958949	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:14958949G>A	uc001rck.1	-	2	739	c.666C>T	c.(664-666)CAC>CAT	p.H222H	WBP11_uc001rci.2_5'Flank|C12orf60_uc001rcj.3_Intron	NM_001013698	NP_001013720	A2RU48	CL069_HUMAN	hypothetical protein LOC440087	222						integral to membrane					0						ATTTCATTTGGTGTTTCACTG	0.368													31	57					0	0	0.00178596	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19418703	19418704	+	Silent	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:19418703_19418704CC>TT	uc001reb.2	+	8	716_717	c.630_631CC>TT	c.(628-633)ATCCTG>ATTTTG	p.210_211IL>IL	PLEKHA5_uc010sie.1_Silent_p.210_211IL>IL|PLEKHA5_uc001rea.2_Silent_p.210_211IL>IL|PLEKHA5_uc009zin.2_5'UTR|PLEKHA5_uc010sif.1_Silent_p.102_103IL>IL|PLEKHA5_uc010sig.1_Silent_p.102_103IL>IL|PLEKHA5_uc010sih.1_Silent_p.102_103IL>IL	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	210_211	PH.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					AAGAGGGTATCCTGGGAAGCAT	0.317													36	88					0	0	6.4e-05	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20854341	20854341	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:20854341G>A	uc001rej.3	+	4	574	c.219G>A	c.(217-219)AGG>AGA	p.R73R	SLCO1C1_uc010sii.1_Silent_p.R73R|SLCO1C1_uc010sij.1_Silent_p.R73R|SLCO1C1_uc009zip.2_Intron|SLCO1C1_uc001rei.2_Silent_p.R73R|SLCO1C1_uc010sik.1_Intron	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	73	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TAGAGAGAAGGTTTGATATCC	0.393													32	52					0	0	0.00058488	0	0
CASC1	55259	broad.mit.edu	37	12	25267737	25267737	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:25267737G>A	uc001rgl.2	-	12	1528	c.1446C>T	c.(1444-1446)TTC>TTT	p.F482F	CASC1_uc001rgk.2_Silent_p.F488F|CASC1_uc001rgm.3_Silent_p.F546F|CASC1_uc001rgj.2_Silent_p.F442F|CASC1_uc010sje.1_Silent_p.F423F|CASC1_uc010sjf.1_Silent_p.F370F|CASC1_uc010sjg.1_3'UTR	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	482										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			TGTCCAGGCTGAATGTTACAA	0.383													21	46					0	0	0.00229938	0	0
ITPR2	3709	broad.mit.edu	37	12	26714877	26714877	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:26714877G>A	uc001rhg.2	-	35	5056	c.4639C>T	c.(4639-4641)CGT>TGT	p.R1547C		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1547	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					GCAATTCCACGATTTTTTGCT	0.323													13	26					0	0	0.000308642	0	0
TMTC1	83857	broad.mit.edu	37	12	29786178	29786178	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:29786178G>A	uc001rjb.2	-	6	1180	c.706C>T	c.(706-708)CCT>TCT	p.P236S	TMTC1_uc001riz.2_5'UTR|TMTC1_uc001rja.2_Missense_Mutation_p.P80S|TMTC1_uc001rjc.1_Missense_Mutation_p.P298S	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	344						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TCTACCAGAGGAATACTGCCG	0.507													34	50					0	0	0.000491102	0	0
BICD1	636	broad.mit.edu	37	12	32481244	32481244	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:32481244C>T	uc001rku.2	+	5	1936	c.1855C>T	c.(1855-1857)CGC>TGC	p.R619C	BICD1_uc001rkv.2_Missense_Mutation_p.R619C|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	619					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AAGTGACATCCGCAAAGAGCC	0.483													54	77					0	0	0.000781405	0	0
KIF21A	55605	broad.mit.edu	37	12	39731002	39731002	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:39731002G>A	uc001rly.2	-	17	2460	c.2314C>T	c.(2314-2316)CGC>TGC	p.R772C	KIF21A_uc001rlw.2_Missense_Mutation_p.R89C|KIF21A_uc001rlx.2_Missense_Mutation_p.R759C|KIF21A_uc001rlz.2_Missense_Mutation_p.R759C|KIF21A_uc010skl.1_Missense_Mutation_p.R759C	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	772					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TTCATTAGGCGAACCTAACCA	0.338													20	33					0	0	0.00121646	0	0
C12orf40	283461	broad.mit.edu	37	12	40114841	40114841	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:40114841G>A	uc001rmc.2	+	13	1914	c.1747G>A	c.(1747-1749)GAT>AAT	p.D583N	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	583										ovary(6)	6						CAAAACCAATGATAACTGCGT	0.398													23	39					0	0	0.00229938	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967587	41967587	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:41967587A>T	uc010skn.1	+	10	2477	c.2409A>T	c.(2407-2409)AAA>AAT	p.K803N	PDZRN4_uc001rmq.3_Missense_Mutation_p.K744N|PDZRN4_uc009zjz.2_Missense_Mutation_p.K742N|PDZRN4_uc001rmr.2_Missense_Mutation_p.K629N	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	1002							ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAACAAGAAAATTTTGGACA	0.463													13	31					0	0	0.00185496	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43862502	43862502	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:43862502G>A	uc010skx.1	-	8	1124	c.1124C>T	c.(1123-1125)TCA>TTA	p.S375L		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	375	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		ACCTAAATATGATAAACCTGA	0.308													29	34					0	0	0.001512	0	0
DBX2	440097	broad.mit.edu	37	12	45429804	45429804	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:45429804G>A	uc001rok.1	-	2	669	c.497C>T	c.(496-498)CCA>CTA	p.P166L		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	166						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		aaacttacttggaaaagcagt	0.154													9	18					0	0	0.000978159	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48141519	48141519	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:48141519G>A	uc009zkp.2	-	13	1763	c.1323C>T	c.(1321-1323)GAC>GAT	p.D441D	RAPGEF3_uc001rpx.2_5'Flank|RAPGEF3_uc010sln.1_Silent_p.D5D|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Silent_p.D441D|RAPGEF3_uc001rpz.3_Silent_p.D483D|RAPGEF3_uc001rqa.2_Silent_p.D5D	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	441					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TGGCCACAGGGTCAGTGTGGA	0.637													12	27					0	0	0.000219431	0	0
ZNF641	121274	broad.mit.edu	37	12	48737346	48737346	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:48737346G>A	uc001rrn.1	-	6	892	c.727C>T	c.(727-729)CTT>TTT	p.L243F	ZNF641_uc001rro.1_Missense_Mutation_p.L229F|ZNF641_uc010sls.1_Missense_Mutation_p.L220F	NM_152320	NP_689533	Q96N77	ZN641_HUMAN	zinc finger protein 641	243	Transactivation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TCTTCCTGAAGAAAAGGGGGC	0.532													10	30					0	0	0.00136819	0	0
MCRS1	10445	broad.mit.edu	37	12	49952686	49952686	+	Silent	SNP	G	A	A	rs144884321		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:49952686G>A	uc001ruk.1	-	14	1433	c.1242C>T	c.(1240-1242)ATC>ATT	p.I414I	MCRS1_uc001rui.1_Silent_p.I427I|MCRS1_uc001ruj.1_Silent_p.I401I|MCRS1_uc001rul.1_Silent_p.I414I|MCRS1_uc009zlj.1_Silent_p.I223I|MCRS1_uc001rum.1_Silent_p.I401I	NM_006337	NP_006328	Q96EZ8	MCRS1_HUMAN	microspherule protein 1 isoform 1	414	FHA.				DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			large_intestine(1)	1						GCCGTCCATCGATGTAGATGG	0.552													24	37					0	0	0.000586117	0	0
TMPRSS12	283471	broad.mit.edu	37	12	51281090	51281090	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:51281090A>G	uc001rwx.3	+	5	888	c.841A>G	c.(841-843)AGA>GGA	p.R281G	TMPRSS12_uc001rwy.2_3'UTR	NM_182559	NP_872365	Q86WS5	TMPSC_HUMAN	transmembrane protease, serine 12 precursor	281	Peptidase S1.|Extracellular (Potential).				proteolysis	integral to membrane	serine-type endopeptidase activity				0						AGAATATAAAAGATTTTTTGT	0.408													17	33					0	0	0.000422831	0	0
SLC4A8	9498	broad.mit.edu	37	12	51851149	51851149	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:51851149C>T	uc001rys.1	+	6	767	c.589C>T	c.(589-591)CAG>TAG	p.Q197*	SLC4A8_uc010sni.1_Nonsense_Mutation_p.Q144*|SLC4A8_uc001rym.2_Nonsense_Mutation_p.Q144*|SLC4A8_uc001ryn.2_Nonsense_Mutation_p.Q144*|SLC4A8_uc001ryo.2_Nonsense_Mutation_p.Q144*|SLC4A8_uc001ryp.1_Nonsense_Mutation_p.Q144*|SLC4A8_uc010snj.1_Nonsense_Mutation_p.Q224*|SLC4A8_uc001ryq.3_Nonsense_Mutation_p.Q197*|SLC4A8_uc001ryr.2_Nonsense_Mutation_p.Q197*|SLC4A8_uc010snk.1_Nonsense_Mutation_p.Q144*	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	197	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		GATCCTGGATCAGCAAGAACT	0.473													25	30					0	0	0.00106085	0	0
KRT85	3891	broad.mit.edu	37	12	52760976	52760977	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:52760976_52760977GG>AA	uc001sag.2	-	1	333_334	c.213_214CC>TT	c.(211-216)TTCCGA>TTTTGA	p.R72*		NM_002283	NP_002274	P78386	KRT85_HUMAN	keratin 85	72	Head.				epidermis development	keratin filament	protein binding|structural molecule activity			ovary(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GAGCCGGCTCGGAAGCCACCTA	0.698													13	21					0	0	6.4e-05	0	0
KRT76	51350	broad.mit.edu	37	12	53166662	53166662	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:53166662C>T	uc001sax.2	-	4	931	c.877G>A	c.(877-879)GAT>AAT	p.D293N		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	293	Coil 1B.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						GCATCCACATCCTGCAGAGGA	0.552													24	39					0	0	0.000375601	0	0
SP7	121340	broad.mit.edu	37	12	53722232	53722232	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:53722232C>T	uc001sct.2	-	2	1101	c.994G>A	c.(994-996)GGC>AGC	p.G332S	SP7_uc001scu.2_Missense_Mutation_p.G314S|SP7_uc001scv.2_Missense_Mutation_p.G332S	NM_152860	NP_690599	Q8TDD2	SP7_HUMAN	osterix	332	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AACCTCTTGCCGCAGAAGAGC	0.617													12	32					0	0	0.00185496	0	0
AMHR2	269	broad.mit.edu	37	12	53819505	53819505	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:53819505G>A	uc001scx.1	+	6	732	c.654G>A	c.(652-654)TGG>TGA	p.W218*	AMHR2_uc009zmy.1_Nonsense_Mutation_p.W218*	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	218	Cytoplasmic (Potential).|Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	CAGTGGTTTGGGCCGGGCAGC	0.582									Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				7	14					0	0	0.000274275	0	0
PDE1B	5153	broad.mit.edu	37	12	54966942	54966942	+	Missense_Mutation	SNP	C	T	T	rs137936270		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:54966942C>T	uc001sgd.1	+	8	912	c.746C>T	c.(745-747)TCG>TTG	p.S249L	PDE1B_uc010soz.1_Missense_Mutation_p.S112L|PDE1B_uc010spa.1_Missense_Mutation_p.S208L|PDE1B_uc001sgf.2_Missense_Mutation_p.S112L|PDE1B_uc001sge.2_Missense_Mutation_p.S229L|PDE1B_uc009znq.2_Missense_Mutation_p.S45L	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	249	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CACTGCCTGTCGGAGATTGAG	0.542													30	51					0	0	0.00058488	0	0
OR6C68	403284	broad.mit.edu	37	12	55886239	55886239	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:55886239C>T	uc010spo.1	+	1	93	c.93C>T	c.(91-93)TTC>TTT	p.F31F		NM_001005519	NP_001005519	A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTCTGCTTTTCATGTTTCTAT	0.413													47	62					0	0	0.000781405	0	0
OR10P1	121130	broad.mit.edu	37	12	56031458	56031459	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:56031458_56031459CC>TT	uc010spq.1	+	1	783_784	c.783_784CC>TT	c.(781-786)ATCCGG>ATTTGG	p.R262W		NM_206899	NP_996782	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						TCACCTACATCCGGCCGCAGGC	0.579													27	55					0	0	6.4e-05	0	0
SMARCC2	6601	broad.mit.edu	37	12	56566415	56566415	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:56566415A>G	uc001skb.2	-	18	1830	c.1724T>C	c.(1723-1725)TTT>TCT	p.F575S	SMARCC2_uc001skd.2_Missense_Mutation_p.F606S|SMARCC2_uc001ska.2_Missense_Mutation_p.F606S|SMARCC2_uc001skc.2_Missense_Mutation_p.F605S|SMARCC2_uc010sqf.1_Missense_Mutation_p.F495S	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	575					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GCGCAGCCCAAAGTTTTGCAT	0.488													32	51					0	0	0.00209593	0	0
PAN2	9924	broad.mit.edu	37	12	56715907	56715907	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:56715907G>A	uc001skx.2	-	20	3128	c.2755C>T	c.(2755-2757)CTT>TTT	p.L919F	PAN2_uc001skw.2_Missense_Mutation_p.L67F|PAN2_uc001skz.2_Missense_Mutation_p.L918F|PAN2_uc001sky.2_Missense_Mutation_p.L915F	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	919					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						ACATAATAAAGGATTGCAGGT	0.403													48	77					0	0	0.000781405	0	0
INHBC	3626	broad.mit.edu	37	12	57843541	57843541	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:57843541C>T	uc001snv.1	+	2	922	c.795C>T	c.(793-795)ATC>ATT	p.I265I		NM_005538	NP_005529	P55103	INHBC_HUMAN	inhibin beta C chain preproprotein	265					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding				0						ACGACTGGATCATCCAGCCTG	0.552													8	36					0	0	0.000442599	0	0
BEST3	144453	broad.mit.edu	37	12	70070720	70070720	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:70070720G>A	uc001svg.2	-	7	1070	c.843C>T	c.(841-843)TTC>TTT	p.F281F	BEST3_uc001svd.1_Silent_p.F281F|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Intron|BEST3_uc010stm.1_Silent_p.F175F|BEST3_uc001svh.2_Intron	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	281	Helical; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CATAGAAGAAGAATTGTAGGA	0.478													43	82					0	0	0.000680045	0	0
PTPRB	5787	broad.mit.edu	37	12	70988397	70988397	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:70988397C>T	uc001swb.3	-	4	742	c.712G>A	c.(712-714)GAT>AAT	p.D238N	PTPRB_uc010sto.1_Missense_Mutation_p.D238N|PTPRB_uc010stp.1_Missense_Mutation_p.D238N|PTPRB_uc001swc.3_Missense_Mutation_p.D456N|PTPRB_uc001swa.3_Missense_Mutation_p.D456N|PTPRB_uc001swd.3_Missense_Mutation_p.D455N|PTPRB_uc009zrr.1_Missense_Mutation_p.D335N|PTPRB_uc001swe.2_Missense_Mutation_p.D456N	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	238	Fibronectin type-III 3.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATCCCTTTATCCATTAGCATC	0.468													17	42					0	0	0.00121646	0	0
NAV3	89795	broad.mit.edu	37	12	78400636	78400636	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:78400636C>T	uc001syp.2	+	8	1491	c.1318C>T	c.(1318-1320)CCC>TCC	p.P440S	NAV3_uc001syo.2_Missense_Mutation_p.P440S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	440						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAATAGCAGTCCCAAAGTGTC	0.423										HNSCC(70;0.22)			36	64					0	0	0.000814825	0	0
NAV3	89795	broad.mit.edu	37	12	78562585	78562585	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:78562585G>T	uc001syp.2	+	24	5093	c.4920G>T	c.(4918-4920)CAG>CAT	p.Q1640H	NAV3_uc001syo.2_Missense_Mutation_p.Q1640H|NAV3_uc010sub.1_Missense_Mutation_p.Q1126H|NAV3_uc009zsf.2_Missense_Mutation_p.Q471H	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1640	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TGAAGGCTCAGAATTCTGCTG	0.393										HNSCC(70;0.22)			39	78					2.13384e-23	8.92302e-23	0.000781405	1	0
MGAT4C	25834	broad.mit.edu	37	12	86373853	86373853	+	Silent	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:86373853T>A	uc001tai.3	-	8	1901	c.651A>T	c.(649-651)TCA>TCT	p.S217S	MGAT4C_uc001tal.3_Silent_p.S217S|MGAT4C_uc001taj.3_Silent_p.S217S|MGAT4C_uc001tak.3_Silent_p.S217S|MGAT4C_uc010sum.1_Silent_p.S241S|MGAT4C_uc001tah.3_Silent_p.S217S	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	217	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						CATAATAGTCTGAAGTATTGG	0.333													21	33					0	0	0.00152264	0	0
Unknown	0	broad.mit.edu	37	12	95228349	95228349	+	RNA	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:95228349A>T	uc001tdk.2	+	1		c.176A>T								Homo sapiens mRNA for keratin 19, partial cds, isolate:K19-141.																		CCTGGCCAGGACTGATCTGGA	0.522													9	7					0	0	0.000442599	0	0
AMDHD1	144193	broad.mit.edu	37	12	96350710	96350710	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:96350710C>T	uc001tel.1	+	4	663	c.557C>T	c.(556-558)GCT>GTT	p.A186V	AMDHD1_uc009zth.1_Missense_Mutation_p.A77V	NM_152435	NP_689648	Q96NU7	HUTI_HUMAN	amidohydrolase domain containing 1	186					histidine catabolic process to glutamate and formamide	cytosol	imidazolonepropionase activity|metal ion binding			central_nervous_system(1)	1						GGCATCTCGGCTACCTACTGC	0.612													37	83					0	0	0.000589545	0	0
C12orf42	374470	broad.mit.edu	37	12	103700002	103700002	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:103700002G>A	uc001tjt.2	-	5	469	c.381C>T	c.(379-381)TTC>TTT	p.F127F	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Silent_p.F127F|C12orf42_uc001tju.2_Silent_p.F32F	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	127										ovary(1)|central_nervous_system(1)	2						GAGAGGAACGGAATTCTTCAT	0.463													15	25					0	0	0.00074312	0	0
STAB2	55576	broad.mit.edu	37	12	104092977	104092977	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:104092977T>A	uc001tjw.2	+	34	3872	c.3686T>A	c.(3685-3687)TTC>TAC	p.F1229Y		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1229	Extracellular (Potential).|FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TTCTCCTATTTCCTTAGCTTC	0.478													12	15					0	0	0.00185496	0	0
TDG	6996	broad.mit.edu	37	12	104376924	104376924	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:104376924C>T	uc001tkg.2	+	6	848	c.625C>T	c.(625-627)CGT>TGT	p.R209C	TDG_uc009zuk.2_Missense_Mutation_p.R205C|TDG_uc010swi.1_Missense_Mutation_p.R66C|TDG_uc010swj.1_Intron	NM_003211	NP_003202	Q13569	TDG_HUMAN	thymine-DNA glycosylase	209					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			ovary(3)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(302;0.00114)		TAAAGAATTTCGTGAAGGAGG	0.249								BER_DNA_glycosylases					80	126					0	0	0.000781405	0	0
RFX4	5992	broad.mit.edu	37	12	107126816	107126816	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:107126816C>T	uc001tlr.2	+	15	1652	c.1586C>T	c.(1585-1587)TCC>TTC	p.S529F	RFX4_uc001tls.2_Missense_Mutation_p.S538F|RFX4_uc001tlt.2_Missense_Mutation_p.S538F|RFX4_uc001tlv.2_Missense_Mutation_p.S435F	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	529					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						CCTCCCTCTTCCCCTGTTAGC	0.498													41	63					0	0	0.000680045	0	0
BTBD11	121551	broad.mit.edu	37	12	108029125	108029125	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:108029125C>T	uc001tmk.1	+	12	3216	c.2695C>T	c.(2695-2697)CCC>TCC	p.P899S	BTBD11_uc009zut.1_Missense_Mutation_p.P780S|BTBD11_uc001tmj.2_Missense_Mutation_p.P899S|BTBD11_uc001tml.1_Missense_Mutation_p.P436S|BTBD11_uc001tmm.1_5'UTR	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	899						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CTACCCCATCCCCAAGCTCAC	0.547													30	44					0	0	0.00209593	0	0
CMKLR1	1240	broad.mit.edu	37	12	108685854	108685854	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:108685854G>A	uc009zuw.2	-	3	1077	c.886C>T	c.(886-888)CTG>TTG	p.L296L	CMKLR1_uc001tmw.2_Silent_p.L296L|CMKLR1_uc001tmv.2_Silent_p.L294L|CMKLR1_uc009zuv.2_Silent_p.L296L	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	296	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						GGCAAACCCAGGCTGAAGACA	0.542													16	28					0	0	0.000422831	0	0
ACACB	32	broad.mit.edu	37	12	109698356	109698356	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:109698356C>T	uc001tob.2	+	48	6687	c.6568C>T	c.(6568-6570)CTG>TTG	p.L2190L	ACACB_uc001toc.2_Silent_p.L2190L|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.L856L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2190	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	ACAGCCCATCCTGATCTATAT	0.522													53	101					0	0	0.000781405	0	0
BRAP	8315	broad.mit.edu	37	12	112121036	112121037	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:112121036_112121037GG>AA	uc001tsn.3	-	2	351_352	c.157_158CC>TT	c.(157-159)CCA>TTA	p.P53L	BRAP_uc010syh.1_5'Flank|BRAP_uc009zvv.2_Missense_Mutation_p.P23L|ACAD10_uc009zvw.2_5'Flank|ACAD10_uc001tso.3_5'Flank|ACAD10_uc001tsp.2_5'Flank|ACAD10_uc009zvx.2_5'Flank|ACAD10_uc001tsq.2_5'Flank	NM_006768	NP_006759	Q7Z569	BRAP_HUMAN	BRCA1 associated protein	53					MAPKKK cascade|negative regulation of signal transduction|Ras protein signal transduction	cytoplasm|ubiquitin ligase complex	identical protein binding|nuclear localization sequence binding|nucleotide binding|ubiquitin-protein ligase activity|zinc ion binding			lung(1)	1						TTTCTCTCCTGGTGACTTGCCT	0.441													56	97					0	0	6.4e-05	0	0
NAA25	80018	broad.mit.edu	37	12	112498129	112498129	+	Silent	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:112498129A>T	uc001ttm.2	-	13	1412	c.1392T>A	c.(1390-1392)TCT>TCA	p.S464S	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Silent_p.S436S|NAA25_uc009zwa.1_Silent_p.S464S	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	464						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						AGTAATAGTCAGAAAATTGCA	0.348													19	48					0	0	0.000586117	0	0
RPH3A	22895	broad.mit.edu	37	12	113328703	113328703	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:113328703C>T	uc010syl.1	+	19	2032	c.1670C>T	c.(1669-1671)TCC>TTC	p.S557F	RPH3A_uc001ttz.2_Missense_Mutation_p.S557F|RPH3A_uc001tty.2_Missense_Mutation_p.S553F|RPH3A_uc009zwe.1_Missense_Mutation_p.S552F|RPH3A_uc010sym.1_Missense_Mutation_p.S508F|RPH3A_uc001tua.2_Missense_Mutation_p.S317F	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	557	C2 2.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ATCCTGGTCTCCCTCATGTAC	0.602													7	12					0	0	0.000157383	0	0
IQCD	115811	broad.mit.edu	37	12	113645327	113645327	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:113645327G>A	uc001tuv.1	-	2	1067	c.645C>T	c.(643-645)ATC>ATT	p.I215I	IQCD_uc001tuu.2_Silent_p.I215I	NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	215										ovary(1)	1						TCTGTCTACTGATATCCTGTA	0.398													25	53					0	0	0.000586117	0	0
NOS1	4842	broad.mit.edu	37	12	117726024	117726024	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:117726024C>T	uc001twm.1	-	5	1668	c.982G>A	c.(982-984)GAA>AAA	p.E328K		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	328					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CATCCCGTTTCCTGGAAGATC	0.507													26	45					0	0	0.001512	0	0
KSR2	283455	broad.mit.edu	37	12	117968819	117968819	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:117968819C>T	uc001two.2	-	12	1698	c.1643_splice	c.e12-1	p.D548_splice		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2						intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGCACCACATCTGAAAACCAG	0.547													44	92					0	0	0.000781405	0	0
TAOK3	51347	broad.mit.edu	37	12	118693341	118693341	+	Missense_Mutation	SNP	A	G	G	rs61945215		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:118693341A>G	uc001twx.2	-	3	327	c.32T>C	c.(31-33)ATT>ACT	p.I11T	TAOK3_uc001twy.3_Missense_Mutation_p.I11T	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	11					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TAGATCGGCAATCTCTGGGTC	0.378													51	103					0	0	0.000781405	0	0
OASL	8638	broad.mit.edu	37	12	121469308	121469308	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:121469308G>A	uc001tzj.1	-	3	600	c.594C>T	c.(592-594)TTC>TTT	p.F198F	OASL_uc001tzk.1_Silent_p.F198F	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	198					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GATGTTTCACGAAATTTCTCT	0.587													107	199					0	0	0.000781405	0	0
KDM2B	84678	broad.mit.edu	37	12	121986882	121986882	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:121986882G>A	uc001uat.2	-	6	687	c.583C>T	c.(583-585)CTG>TTG	p.L195L	KDM2B_uc001uas.2_Silent_p.L164L|KDM2B_uc001uau.2_Silent_p.L78L|KDM2B_uc001uav.3_Silent_p.L195L	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	195	JmjC.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CAGTCCACCAGGTCTACCTGA	0.562													17	24					0	0	0.000958276	0	0
LRRC43	254050	broad.mit.edu	37	12	122669150	122669150	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:122669150G>A	uc009zxm.2	+	2	260	c.235G>A	c.(235-237)GAG>AAG	p.E79K	LRRC43_uc001ubw.3_5'UTR|LRRC43_uc009zxl.1_RNA	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	79											0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		CCCCGGAGAGGAGACGGTGGA	0.597													9	16					0	0	0.000274275	0	0
EIF2B1	1967	broad.mit.edu	37	12	124114980	124114980	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:124114980G>A	uc001ufm.2	-	3	359	c.216C>T	c.(214-216)TTC>TTT	p.F72F	EIF2B1_uc001ufn.2_Silent_p.F72F|EIF2B1_uc010tat.1_Silent_p.F72F	NM_001414	NP_001405	Q14232	EI2BA_HUMAN	eukaryotic translation initiation factor 2B,	72					cellular response to stimulus|oligodendrocyte development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex|membrane fraction|plasma membrane	protein binding|translation initiation factor activity				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.67e-05)|Epithelial(86;0.000353)|all cancers(50;0.00489)		TGAAGCGGAGGAAGAGCTCCC	0.552													15	21					0	0	0.000308642	0	0
ZNF664	144348	broad.mit.edu	37	12	124497283	124497284	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:124497283_124497284CC>TT	uc001ufz.2	+	6	2422_2423	c.592_593CC>TT	c.(592-594)CCC>TTC	p.P198F	ZNF664_uc001uga.2_Missense_Mutation_p.P198F|ZNF664_uc001ugb.2_Missense_Mutation_p.P198F	NM_152437	NP_689650	Q8N3J9	ZN664_HUMAN	zinc finger protein 664	198				P -> H (in Ref. 4; AAH51696).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)		TGGAGAGAAACCCTATAGATGT	0.5													24	35					0	0	6.4e-05	0	0
TMEM132D	121256	broad.mit.edu	37	12	130185047	130185047	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:130185047G>A	uc009zyl.1	-	2	604	c.276C>T	c.(274-276)GTC>GTT	p.V92V		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	92	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGGCATTGAGGACAGGCAGCC	0.502													21	32					0	0	0.00229938	0	0
POLE	5426	broad.mit.edu	37	12	133249242	133249242	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr12:133249242G>A	uc001uks.1	-	15	1701	c.1657C>T	c.(1657-1659)CGC>TGC	p.R553C	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R526C	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	553					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		ATATCGCTGCGGAAAACCCCA	0.587								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					27	40					0	0	0.00178596	0	0
IFT88	8100	broad.mit.edu	37	13	21217703	21217703	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:21217703C>T	uc001unh.2	+	21	2215	c.1819C>T	c.(1819-1821)CGT>TGT	p.R607C	IFT88_uc001uni.2_Missense_Mutation_p.R598C|IFT88_uc001unj.2_Missense_Mutation_p.R597C|IFT88_uc010tcq.1_Missense_Mutation_p.R578C	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	607	TPR 10.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		ATTATATGATCGTGAAGGAGA	0.338													23	48					0	0	0.000720815	0	0
SACS	26278	broad.mit.edu	37	13	23907016	23907016	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:23907016G>A	uc001uon.2	-	10	11588	c.10999C>T	c.(10999-11001)CAT>TAT	p.H3667Y	SACS_uc001uoo.2_Missense_Mutation_p.H3520Y|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3667					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TATTGAGGATGAAATCTAATG	0.383													22	40					0	0	0.00229938	0	0
FLT1	2321	broad.mit.edu	37	13	29012394	29012394	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:29012394C>T	uc001usb.3	-	4	762	c.477G>A	c.(475-477)CGG>CGA	p.R159R	FLT1_uc010aar.1_Silent_p.R159R|FLT1_uc001usc.3_Silent_p.R159R|FLT1_uc010tdp.1_Silent_p.R159R	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	159	Ig-like C2-type 2.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity	p.R159R(1)		lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GTGACGTAACCCGGCAGGGAA	0.398													18	28					0	0	0.000566183	0	0
MTUS2	23281	broad.mit.edu	37	13	30066811	30066811	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:30066811G>A	uc001usl.3	+	10	3622	c.3564G>A	c.(3562-3564)AAG>AAA	p.K1188K	MTUS2_uc001usm.3_Silent_p.K157K|MTUS2_uc010aau.2_Silent_p.K67K	NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	1178	Potential.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AGCTTGAAAAGAAAGAATTGG	0.343													23	36					0	0	0.000720815	0	0
B3GALTL	145173	broad.mit.edu	37	13	31903644	31903644	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:31903644C>T	uc010aaz.2	+	15	1446	c.1336C>T	c.(1336-1338)CCG>TCG	p.P446S	B3GALTL_uc001utn.3_RNA|B3GALTL_uc001uto.3_Missense_Mutation_p.P51S	NM_194318	NP_919299	Q6Y288	B3GLT_HUMAN	beta 1,3-galactosyltransferase-like	446	Lumenal (Potential).				fucose metabolic process	endoplasmic reticulum membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2		Lung SC(185;0.0257)		all cancers(112;0.00436)|Epithelial(112;0.0285)|OV - Ovarian serous cystadenocarcinoma(117;0.0512)|GBM - Glioblastoma multiforme(144;0.184)		GCAGGCTCGGCCGGTGGATTA	0.418													40	57					0	0	0.000589545	0	0
RXFP2	122042	broad.mit.edu	37	13	32366933	32366933	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:32366933G>A	uc001utt.2	+	16	1565	c.1494G>A	c.(1492-1494)ATG>ATA	p.M498I	RXFP2_uc010aba.2_Missense_Mutation_p.M457I	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	498	Helical; Name=3; (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		GCCGCCTCATGGGGTTCCTGG	0.483													22	27					0	0	0.00047179	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33016551	33016551	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:33016551A>C	uc010abe.1	-	7	2145	c.2123T>G	c.(2122-2124)CTT>CGT	p.L708R	N4BP2L2_uc001uug.2_Missense_Mutation_p.L591R|N4BP2L2_uc010abd.1_Missense_Mutation_p.L621R|N4BP2L2_uc001uuh.2_Missense_Mutation_p.L539R|N4BP2L2_uc001uuj.2_Missense_Mutation_p.L127R|N4BP2L2_uc010tdz.1_Missense_Mutation_p.L693R	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		AGATCCAAAAAGCTTTACTAA	0.398													10	10					0	0	0.000673444	0	0
SMAD9	4093	broad.mit.edu	37	13	37453563	37453563	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:37453563G>A	uc001uvw.2	-	2	607	c.264C>T	c.(262-264)CCC>CCT	p.P88P	SMAD9_uc001uvx.2_Silent_p.P88P|SMAD9_uc010tep.1_5'UTR	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	88	MH1.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		AAATCACATGGGGCAGGCCCT	0.652													11	17					0	0	0.00136819	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37678626	37678626	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:37678626G>A	uc001uwm.1	-	1	1176	c.768C>T	c.(766-768)TTC>TTT	p.F256F		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	256	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		AGTACATGGCGAATTCTGCAG	0.433													43	48					0	0	0.00222228	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679361	37679361	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:37679361G>A	uc001uwm.1	-	1	441	c.33C>T	c.(31-33)CTC>CTT	p.L11L		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	11					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		CTCCCACAACGAGTTCGGCTT	0.592													38	46					0	0	0.000781405	0	0
POSTN	10631	broad.mit.edu	37	13	38144728	38144728	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:38144728C>T	uc001uwo.3	-	19	2376	c.2258G>A	c.(2257-2259)CGA>CAA	p.R753Q	POSTN_uc010tet.1_Missense_Mutation_p.R254Q|POSTN_uc001uwp.3_Missense_Mutation_p.R696Q|POSTN_uc001uwr.2_Missense_Mutation_p.R726Q|POSTN_uc001uwq.2_Missense_Mutation_p.R696Q|POSTN_uc010teu.1_Missense_Mutation_p.R726Q|POSTN_uc010tev.1_Intron|POSTN_uc010tew.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	753					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TGTAATGATTCGTTCTTCTCG	0.318													23	40					0	0	0.000720815	0	0
KBTBD6	89890	broad.mit.edu	37	13	41705314	41705314	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:41705314G>A	uc001uxu.1	-	1	1623	c.1334C>T	c.(1333-1335)CCT>CTT	p.P445L	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.P379L|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	445	Kelch 2.						protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		TCCAGTAATAGGGTCTCGCCC	0.468													34	50					0	0	0.000814825	0	0
AKAP11	11215	broad.mit.edu	37	13	42875532	42875532	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:42875532G>T	uc001uys.1	+	8	2825	c.2650G>T	c.(2650-2652)GTA>TTA	p.V884L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	884					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GCATACGATAGTAAATGAAAC	0.338													5	28					1.23904e-05	5.13303e-05	0.000602214	1	0
UTP14C	9724	broad.mit.edu	37	13	52604978	52604978	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:52604978C>T	uc001vgb.2	+	2	2573	c.2038C>T	c.(2038-2040)CAG>TAG	p.Q680*	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	680					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		AGCAGCTCATCAGGTACAAGT	0.473													68	103					0	0	0.000781405	0	0
DIAPH3	81624	broad.mit.edu	37	13	60453373	60453373	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:60453373G>A	uc001vht.2	-	21	2816	c.2597C>T	c.(2596-2598)TCT>TTT	p.S866F	DIAPH3_uc001vhu.2_Missense_Mutation_p.S603F|DIAPH3_uc001vhv.2_Missense_Mutation_p.S444F	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	866	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TTTACAGAGAGAGCTAAGGTT	0.353													13	26					0	0	0.000219431	0	0
IPO5	3843	broad.mit.edu	37	13	98664589	98664589	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:98664589C>T	uc001vnf.1	+	18	2210	c.2145C>T	c.(2143-2145)TTC>TTT	p.F715F	IPO5_uc001vne.2_Silent_p.F733F|IPO5_uc010tik.1_Silent_p.F590F|IPO5_uc010til.1_Silent_p.F655F|IPO5_uc001vng.1_Silent_p.F336F	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	715					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						AATTTTATTTCCACGATGATA	0.368													21	51					0	0	0.00121646	0	0
SLC15A1	6564	broad.mit.edu	37	13	99356685	99356685	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:99356685T>A	uc001vno.2	-	17	1351	c.1274A>T	c.(1273-1275)AAT>ATT	p.N425I		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	425	Extracellular (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CATAAATGCATTTGTCTATAG	0.418													26	46					0	0	0.00106085	0	0
MCF2L	23263	broad.mit.edu	37	13	113714954	113714954	+	Silent	SNP	G	A	A	rs141848502		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr13:113714954G>A	uc001vsu.2	+	5	610	c.588G>A	c.(586-588)ACG>ACA	p.T196T	MCF2L_uc001vsq.2_Silent_p.T196T|MCF2L_uc010tjr.1_Silent_p.T139T|MCF2L_uc001vsr.2_Silent_p.T143T|MCF2L_uc001vss.3_Silent_p.T137T|MCF2L_uc010tjs.1_Silent_p.T137T|MCF2L_uc001vst.1_Silent_p.T101T	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	169	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TTCGCCCGACGGGTTTTTTCC	0.572													18	9					0	0	0.000958276	0	0
Unknown	0	broad.mit.edu	37	14	19856931	19856931	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:19856931C>T	uc001vvq.1	-	5		c.599G>A								Homo sapiens cDNA FLJ12852 fis, clone NT2RP2003445.																		AACACTTTTTCATAGAATGGC	0.408													7	38					0	0	0.000157383	0	0
TEP1	7011	broad.mit.edu	37	14	20856088	20856088	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:20856088G>A	uc001vxe.2	-	18	2700	c.2660C>T	c.(2659-2661)CCC>CTC	p.P887L	TEP1_uc010ahk.2_Missense_Mutation_p.P237L|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.P779L	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	887					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGGAGCCAAGGGGCTTGGAGT	0.532													23	48					0	0	0.000878237	0	0
OR5AU1	390445	broad.mit.edu	37	14	21623432	21623432	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:21623432G>A	uc010tlp.1	-	1	753	c.753C>T	c.(751-753)TTC>TTT	p.F251F		NM_001004731	NP_001004731	Q8NGC0	O5AU1_HUMAN	olfactory receptor, family 5, subfamily AU,	251	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(95;0.00238)		Epithelial(56;6.88e-07)|all cancers(55;6.02e-06)	GBM - Glioblastoma multiforme(265;0.0192)		CAGCAAAAATGAAGAGCAGGA	0.488													21	28					0	0	0.00229938	0	0
PSMB11	122706	broad.mit.edu	37	14	23512187	23512187	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:23512187C>T	uc010ake.1	+	1	812	c.753C>T	c.(751-753)CTC>CTT	p.L251L		NM_001099780	NP_001093250	A5LHX3	PSB11_HUMAN	proteasome beta 11 subunit precursor	251					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		TACAGAAGCTCCTGGAGCCGG	0.602													7	15					0	0	0.00198382	0	0
CDH24	64403	broad.mit.edu	37	14	23518845	23518846	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:23518845_23518846CC>TT	uc001wil.2	-	11	1961_1962	c.1701_1702GG>AA	c.(1699-1704)CAGGAC>CAAAAC	p.D568N	CDH24_uc001wik.3_RNA|CDH24_uc010akf.2_Missense_Mutation_p.D530N	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	cadherin-like 24 isoform 1	568	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			central_nervous_system(1)	1	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCTCGGTTGTCCTGGACAGTAA	0.594													14	19					0	0	6.4e-05	0	0
SLC7A8	23428	broad.mit.edu	37	14	23600687	23600687	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:23600687G>A	uc001wiz.2	-	8	1822	c.1096C>T	c.(1096-1098)CCA>TCA	p.P366S	SLC7A8_uc001wiw.2_5'Flank|SLC7A8_uc001wix.2_Missense_Mutation_p.P163S|SLC7A8_uc010tnk.1_Missense_Mutation_p.P142S|SLC7A8_uc010tnl.1_Missense_Mutation_p.P261S|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_Intron	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	366	Helical; (Potential).				blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	AGCAGGGCTGGGATTGGGGTG	0.567													15	40					0	0	0.00074312	0	0
SLC7A8	23428	broad.mit.edu	37	14	23635597	23635597	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:23635597T>C	uc001wiz.2	-	2	1030	c.304A>G	c.(304-306)AAA>GAA	p.K102E	SLC7A8_uc010akj.2_Missense_Mutation_p.K102E	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	102					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	CCTCCAGATTTGGGGATGGTG	0.542													41	85					0	0	0.000589545	0	0
MYH6	4624	broad.mit.edu	37	14	23865960	23865960	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:23865960C>T	uc001wjv.2	-	19	2302	c.2235G>A	c.(2233-2235)GAG>GAA	p.E745E		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	745	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TGAGCAGCTTCTCTGTCCCCT	0.562													23	35					0	0	0.000720815	0	0
TINF2	26277	broad.mit.edu	37	14	24710294	24710294	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:24710294G>A	uc001woa.3	-	5	878	c.536C>T	c.(535-537)CCT>CTT	p.P179L	TINF2_uc010alm.2_Missense_Mutation_p.P3L|TINF2_uc001wob.3_Missense_Mutation_p.P179L|TINF2_uc010tof.1_Missense_Mutation_p.P144L|TINF2_uc001woc.3_Intron	NM_001099274	NP_001092744	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	179					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|protein binding|telomeric DNA binding				0				GBM - Glioblastoma multiforme(265;0.0185)		AGAGACTCCAGGCTGCATCCA	0.517									Ataxia_Pancytopenia_syndrome|Congenital_Dyskeratosis				51	90					0	0	0.000781405	0	0
FOXA1	3169	broad.mit.edu	37	14	38061585	38061585	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:38061585T>C	uc001wuf.2	-	2	716	c.404A>G	c.(403-405)AAC>AGC	p.N135S	FOXA1_uc010tpz.1_Missense_Mutation_p.N102S	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	135					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		CATGCACGGGTTCATGGCGGC	0.597													8	10					0	0	0.000157383	0	0
SEC23A	10484	broad.mit.edu	37	14	39536465	39536465	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:39536465G>A	uc001wup.1	-	10	1362	c.1139C>T	c.(1138-1140)TCC>TTC	p.S380F	SEC23A_uc010tqa.1_Missense_Mutation_p.S242F|SEC23A_uc010tqb.1_Missense_Mutation_p.S351F|SEC23A_uc010tqc.1_Missense_Mutation_p.S242F	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	380					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		TTTGAATAAGGAAGTATTGAA	0.358													22	60					0	0	0.00229938	0	0
MIA2	117153	broad.mit.edu	37	14	39717188	39717188	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:39717188C>T	uc001wux.2	+	4	1604	c.1410C>T	c.(1408-1410)TTC>TTT	p.F470F	MIA2_uc010amy.1_Silent_p.F401F	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	470						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		CTTGGAACTTCCAGAACATTC	0.318													43	65					0	0	0.000781405	0	0
GCH1	2643	broad.mit.edu	37	14	55310756	55310756	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:55310756G>A	uc001xbh.1	-	6	893	c.732C>T	c.(730-732)TTC>TTT	p.F244F	GCH1_uc001xbi.1_Silent_p.F244F|GCH1_uc001xbj.1_Intron|GCH1_uc001xbk.1_Intron|GCH1_uc010aol.1_Intron	NM_001024024	NP_001019195	P30793	GCH1_HUMAN	GTP cyclohydrolase 1 isoform 1	244					dopamine biosynthetic process|GTP catabolic process|neuromuscular process controlling posture|nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|protein homooligomerization|response to interferon-gamma|response to lipopolysaccharide|response to pain|response to tumor necrosis factor|tetrahydrobiopterin biosynthetic process|tetrahydrofolate biosynthetic process	cytoplasmic vesicle|cytosol|nuclear membrane|protein complex	GTP binding|GTP cyclohydrolase I activity|protein homodimerization activity|zinc ion binding			skin(1)	1						TGAGAGTCAGGAACTCTTCCC	0.483													20	48					0	0	0.00188189	0	0
HIF1A	3091	broad.mit.edu	37	14	62205038	62205038	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:62205038C>A	uc001xfq.2	+	10	1887	c.1483C>A	c.(1483-1485)CAG>AAG	p.Q495K	HIF1A_uc001xfr.2_Missense_Mutation_p.Q495K|HIF1A_uc001xfs.2_Missense_Mutation_p.Q496K	NM_001530	NP_001521	Q16665	HIF1A_HUMAN	hypoxia-inducible factor 1, alpha subunit	495	ODD.				cellular response to hypoxia|collagen metabolic process|connective tissue replacement involved in inflammatory response wound healing|elastin metabolic process|epithelial to mesenchymal transition|oxygen homeostasis|positive regulation of chemokine production|positive regulation of epithelial cell migration|positive regulation of hormone biosynthetic process|positive regulation of nitric-oxide synthase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of transforming growth factor-beta2 production	cytoplasm|nucleolus|transcription factor complex	histone acetyltransferase binding|Hsp90 protein binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			kidney(3)|lung(1)	4				OV - Ovarian serous cystadenocarcinoma(108;1.62e-09)|BRCA - Breast invasive adenocarcinoma(234;0.189)		GCCCCAGATTCAGGATCAGAC	0.418													89	155					2.18907e-53	9.17554e-53	0.000781405	1	0
SYT16	83851	broad.mit.edu	37	14	62462942	62462942	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:62462942G>A	uc001xfu.1	+	1	402	c.205G>A	c.(205-207)GAT>AAT	p.D69N	SYT16_uc010tsd.1_Missense_Mutation_p.D69N	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	69										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GTACTTTGAAGATGAAGAACA	0.368													61	108					0	0	0.000781405	0	0
SPTB	6710	broad.mit.edu	37	14	65259726	65259726	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:65259726G>A	uc001xht.2	-	13	2709	c.2655C>T	c.(2653-2655)GTC>GTT	p.V885V	SPTB_uc001xhr.2_Silent_p.V885V|SPTB_uc001xhs.2_Silent_p.V885V|SPTB_uc001xhu.2_Silent_p.V885V	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	885	Spectrin 6.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGTGCTGCACGACCTCCAGGT	0.572													11	27					0	0	0.00185496	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68251080	68251080	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:68251080G>A	uc001xka.2	-	20	3736	c.3597C>T	c.(3595-3597)CTC>CTT	p.L1199L	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.L1199L	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1199					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCTCAAACAGGAGATGTGACA	0.488													71	133					0	0	0.000781405	0	0
DCAF5	8816	broad.mit.edu	37	14	69522018	69522018	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:69522018G>A	uc001xkp.2	-	9	1604	c.1385C>T	c.(1384-1386)TCG>TTG	p.S462L	DCAF5_uc001xkq.2_Missense_Mutation_p.S461L	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	462						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						CAATGAGGCCGAAGACTCTGA	0.612													15	22					0	0	0.000308642	0	0
PAPLN	89932	broad.mit.edu	37	14	73720524	73720524	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:73720524C>T	uc010ttx.1	+	11	1320	c.1157C>T	c.(1156-1158)TCC>TTC	p.S386F	PAPLN_uc001xnw.3_Missense_Mutation_p.S359F|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.S386F	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	386	TSP type-1 3.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CAGTCCCGCTCCGTGTACTGC	0.682													21	41					0	0	0.000375601	0	0
C14orf145	145508	broad.mit.edu	37	14	81371267	81371267	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:81371267G>A	uc001xux.2	-	5	541	c.370C>T	c.(370-372)CAT>TAT	p.H124Y	C14orf145_uc001xuz.2_Missense_Mutation_p.H124Y|C14orf145_uc001xva.1_Missense_Mutation_p.H124Y|C14orf145_uc001xuy.1_5'UTR	NM_152446	NP_689659	Q6ZU80	CE128_HUMAN	hypothetical protein LOC145508	124						centriole|spindle pole					0				BRCA - Breast invasive adenocarcinoma(234;0.0586)		GGTGGAAAATGATGGAGCTCT	0.408													33	49					0	0	0.000692331	0	0
STON2	85439	broad.mit.edu	37	14	81837403	81837403	+	Missense_Mutation	SNP	G	A	A	rs146988761	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:81837403G>A	uc010tvu.1	-	3	701	c.500C>T	c.(499-501)TCG>TTG	p.S167L	STON2_uc001xvk.1_Missense_Mutation_p.S167L	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	167					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		ATCTGTATACGAACATCCAAA	0.542													46	64					0	0	0.000781405	0	0
EML5	161436	broad.mit.edu	37	14	89206850	89206850	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:89206850G>A	uc001xxg.2	-	6	778	c.592C>T	c.(592-594)CAG>TAG	p.Q198*		NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	198	WD 4.					cytoplasm|microtubule				ovary(3)	3						AGTATTGTCTGAAGGTCACCC	0.393													52	94					0	0	0.000781405	0	0
FOXN3	1112	broad.mit.edu	37	14	89878430	89878430	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:89878430G>A	uc001xxo.3	-	2	528	c.391C>T	c.(391-393)CCA>TCA	p.P131S	FOXN3_uc001xxn.3_Missense_Mutation_p.P131S|FOXN3_uc010atk.2_Missense_Mutation_p.P131S|FOXN3_uc001xxp.2_Missense_Mutation_p.P131S	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1	131	Fork-head.				DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						CGCTTGGTTGGAGAGTCCTCG	0.512													31	78					0	0	0.00178596	0	0
TDP1	55775	broad.mit.edu	37	14	90509426	90509426	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:90509426T>G	uc001xxy.2	+	17	2065	c.1766T>G	c.(1765-1767)ATA>AGA	p.I589R	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.I589R|TDP1_uc010atn.2_3'UTR|TDP1_uc001xya.2_Missense_Mutation_p.I350R|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Missense_Mutation_p.Y553D	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	589					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		CGGCCATGGATATGGAACATT	0.413								Repair_of_DNA-protein_crosslinks					36	54					0	0	0.00111076	0	0
CATSPERB	79820	broad.mit.edu	37	14	92053616	92053616	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:92053616G>A	uc001xzs.1	-	26	3202	c.3062C>T	c.(3061-3063)TCT>TTT	p.S1021F	CATSPERB_uc010aub.1_Missense_Mutation_p.S543F	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	1021					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				GAAAAGTTCAGAGCCCTGTGG	0.398													24	24					0	0	0.00209593	0	0
TC2N	123036	broad.mit.edu	37	14	92251698	92251698	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:92251698G>A	uc001xzu.3	-	11	1361	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F	TC2N_uc001xzt.3_Silent_p.F390F|TC2N_uc010auc.2_Silent_p.F326F|TC2N_uc001xzv.3_Silent_p.F390F	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	390	C2.					nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		CCACCTTCACGAAAAAACCTA	0.323													81	91					0	0	0.000781405	0	0
SLC24A4	123041	broad.mit.edu	37	14	92958550	92958550	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:92958550C>T	uc001yak.2	+	16	1655	c.1631C>T	c.(1630-1632)TCC>TTC	p.S544F	SLC24A4_uc001yai.2_Missense_Mutation_p.S497F|SLC24A4_uc010twm.1_Missense_Mutation_p.S542F|SLC24A4_uc001yaj.2_Missense_Mutation_p.S525F|SLC24A4_uc010auj.2_Missense_Mutation_p.S433F|SLC24A4_uc010twn.1_Missense_Mutation_p.S317F|SLC24A4_uc001yan.2_Missense_Mutation_p.S255F	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	561	Helical; (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CTGGTCTATTCCGTGGTCCTG	0.512													39	97					0	0	0.000509022	0	0
DDX24	57062	broad.mit.edu	37	14	94526450	94526450	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:94526450A>G	uc001ycj.2	-	5	2006	c.1907T>C	c.(1906-1908)CTG>CCG	p.L636P	DDX24_uc010twq.1_Missense_Mutation_p.L593P|DDX24_uc010twr.1_Missense_Mutation_p.L386P	NM_020414	NP_065147	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	636	Helicase C-terminal.				RNA metabolic process	cytoplasm|nucleolus|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|skin(1)	4		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		TTACTCTTCCAGACGGGCAAA	0.517													29	44					0	0	0.00209593	0	0
SERPINA12	145264	broad.mit.edu	37	14	94964174	94964174	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:94964174C>T	uc001ydj.2	-	3	1357	c.561G>A	c.(559-561)GGG>GGA	p.G187G		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	187					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		TGTTAATTTTCCCATGGGTTT	0.363													31	82					0	0	0.00178596	0	0
SERPINA5	5104	broad.mit.edu	37	14	95053711	95053711	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:95053711C>T	uc001ydm.2	+	3	222	c.12C>T	c.(10-12)TTC>TTT	p.F4F	SERPINA5_uc010ave.2_Silent_p.F4F|SERPINA5_uc001ydn.1_Silent_p.F4F	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	4					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	TGCAGCTCTTCCTCCTCTTGT	0.587													29	64					0	0	0.00058488	0	0
C14orf49	161176	broad.mit.edu	37	14	95903214	95903214	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:95903214G>A	uc001yei.3	-	14	2496	c.2481C>T	c.(2479-2481)ATC>ATT	p.I827I	C14orf49_uc010avi.2_Silent_p.I822I	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	827	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TCATTGCGATGATTCTAACCA	0.493													37	73					0	0	0.00170553	0	0
MIR381	494330	broad.mit.edu	37	14	101512287	101512287	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:101512287C>T	hsa-mir-381|MI0000789	+			c.31C>T			uc010awd.2_RNA|MIR487B_hsa-mir-487b|MI0003530_5'Flank|MIR539_hsa-mir-539|MI0003514_5'Flank|MIR889_hsa-mir-889|MI0005540_5'Flank|MIR544_hsa-mir-544|MI0003515_5'Flank																	0						TTTGTATATTCGGTTTATTGA	0.507													4	12					0	0	0.000602214	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102516782	102516782	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:102516782C>A	uc001yks.2	+	78	13987	c.13823C>A	c.(13822-13824)CCT>CAT	p.P4608H		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4608					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GTAACCTTACCTGTCTACCTG	0.542													8	210					1.12685e-05	4.67551e-05	0.000274275	1	0
RCOR1	23186	broad.mit.edu	37	14	103173840	103173840	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:103173840C>T	uc001ymb.2	+	5	642	c.642C>T	c.(640-642)ATC>ATT	p.I214I		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	214	Interaction with HDAC1.|SANT 1.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						TTCATAGAATCCAACAAATGG	0.368													28	64					0	0	0.00127121	0	0
RCOR1	23186	broad.mit.edu	37	14	103187353	103187353	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:103187353A>G	uc001ymb.2	+	9	1054	c.1054A>G	c.(1054-1056)ATT>GTT	p.I352V		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	REST corepressor 1	352	Potential.|Interaction with KDM1A.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription regulatory region DNA binding			ovary(1)	1						GATCCAGAATATTAAACAGAC	0.284													96	115					0	0	0.000781405	0	0
ASPG	374569	broad.mit.edu	37	14	104571006	104571006	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:104571006G>A	uc001yoq.1	+	9	1044	c.984G>A	c.(982-984)GAG>GAA	p.E328E	ASPG_uc001yoo.1_Silent_p.E356E|ASPG_uc001yop.1_Silent_p.E328E|ASPG_uc001yor.1_Silent_p.E328E	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	328	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						TGACATCGGAGGCCGCCCTGG	0.692													15	27					0	0	0.000219431	0	0
INF2	64423	broad.mit.edu	37	14	105179883	105179883	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:105179883G>A	uc001ypb.2	+	20	3123	c.2980G>A	c.(2980-2982)GGG>AGG	p.G994R	INF2_uc010tyi.1_Missense_Mutation_p.G994R|INF2_uc001ypc.2_Missense_Mutation_p.G994R|INF2_uc010awz.1_RNA	NM_022489	NP_071934	Q27J81	INF2_HUMAN	inverted formin 2 isoform 1	994					actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding				0		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		CCGGGGCCGCGGGGACACCGA	0.667													3	6					0	0	0.00024832	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412741	105412741	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:105412741G>A	uc010axc.1	-	7	9167	c.9047C>T	c.(9046-9048)TCC>TTC	p.S3016F	AHNAK2_uc001ypx.2_Missense_Mutation_p.S2916F	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3016						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCTGCATGGAGGGGAGGCT	0.632													60	109					0	0	0.000781405	0	0
BRF1	2972	broad.mit.edu	37	14	105718852	105718853	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:105718852_105718853GG>AA	uc001yqp.2	-	5	898_899	c.535_536CC>TT	c.(535-537)CCG>TTG	p.P179L	BRF1_uc010tyo.1_Missense_Mutation_p.P64L|BRF1_uc010typ.1_Missense_Mutation_p.P64L|BRF1_uc010axg.1_Missense_Mutation_p.P152L	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	179					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		ACCTATGGCCGGCGCATTGATG	0.53													13	18					0	0	6.4e-05	0	0
ADAM6	8755	broad.mit.edu	37	14	106329413	106329413	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:106329413G>A	uc010tyt.1	-	3592		c.54496C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Missense_Mutation_p.S13F|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysj.2_Missense_Mutation_p.S13F|uc001ysk.1_Missense_Mutation_p.S13F|uc001ysl.1_Missense_Mutation_p.S13F|uc001ysm.1_Intron|uc001ysn.1_Intron|uc001yso.1_Intron					Parts of antibodies, mostly variable regions.												0						CTTACCTGAGGAGACGGTGAC	0.542													8	19					0	0	0.00136819	0	0
ADAM6	8755	broad.mit.edu	37	14	106848862	106848862	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr14:106848862G>A	uc010tyt.1	-	293		c.11987C>T								Parts of antibodies, mostly variable regions.												0						GAGCCTGATGGACCCAGCTCA	0.493													4	7					0	0	0.00024832	0	0
CXADRP2	646243	broad.mit.edu	37	15	22016322	22016322	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:22016322T>G	uc010tzk.1	-	1	557	c.395A>C	c.(394-396)AAA>ACA	p.K132T		NR_024387				RecName: Full=Coxsackievirus and adenovirus receptor; AltName: Full=Coxsackievirus B-adenovirus receptor; AltName: Full=HCVADR;          Short=hCAR; AltName: Full=CVB3-binding protein; Flags: Precursor;												0						ACATTTTAATTTAAAGTCACT	0.388													4	23					0	0	0.00198382	0	0
OR4N3P	390539	broad.mit.edu	37	15	22413843	22413843	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:22413843C>T	uc001yuf.2	+	1	142	c.142C>T	c.(142-144)CTG>TTG	p.L48L		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						CACCATCTGCCTGCCTCTGCA	0.507													24	85					0	0	0.000586117	0	0
Unknown	0	broad.mit.edu	37	15	22440658	22440658	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:22440658C>T	uc001yug.2	-	1	208	c.189G>A	c.(187-189)AGG>AGA	p.R63R						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).																		AGGAGAAATTCCTCACGTCCA	0.537													5	16					0	0	0.000602214	0	0
GABRA5	2558	broad.mit.edu	37	15	27159995	27159995	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:27159995G>A	uc001zbd.1	+	8	882	c.543G>A	c.(541-543)CCG>CCA	p.P181P	GABRB3_uc001zbb.2_Intron	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	181	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGGACTTCCCGATGGATGCGC	0.443													13	31					0	0	0.000422831	0	0
RYR3	6263	broad.mit.edu	37	15	33840366	33840366	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:33840366G>A	uc001zhi.2	+	9	846	c.776G>A	c.(775-777)CGA>CAA	p.R259Q	RYR3_uc010bar.2_Missense_Mutation_p.R259Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	259	MIR 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTGGGACTCGAGCCAGGTCT	0.512													7	23					0	0	0.000157383	0	0
RYR3	6263	broad.mit.edu	37	15	33855110	33855110	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:33855110G>A	uc001zhi.2	+	11	1115	c.1045G>A	c.(1045-1047)GGA>AGA	p.G349R	RYR3_uc010bar.2_Missense_Mutation_p.G349R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	349	Cytoplasmic (By similarity).|MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AATCAAGTATGGAGATTCTGT	0.438													25	45					0	0	0.000720815	0	0
AVEN	57099	broad.mit.edu	37	15	34295320	34295320	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:34295320G>A	uc001zhj.2	-	2	414	c.358C>T	c.(358-360)CGA>TGA	p.R120*	CHRM5_uc001zhk.1_Intron	NM_020371	NP_065104	Q9NQS1	AVEN_HUMAN	cell death regulator aven	120					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			kidney(1)	1		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		TCTTGATATCGATCCCAGTTA	0.403													27	46					0	0	0.000720815	0	0
GPR176	11245	broad.mit.edu	37	15	40099246	40099246	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:40099246G>A	uc001zkj.1	-	2	1252	c.386C>T	c.(385-387)TCT>TTT	p.S129F	GPR176_uc010uck.1_Missense_Mutation_p.S69F	NM_007223	NP_009154	Q14439	GP176_HUMAN	G protein-coupled receptor 176	129	Helical; Name=3; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		all_cancers(109;4.05e-15)|all_epithelial(112;2.96e-13)|Lung NSC(122;8.53e-11)|all_lung(180;2.71e-09)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;4.4e-06)|BRCA - Breast invasive adenocarcinoma(123;0.123)		GATGGTCACAGAGCAGAATAC	0.433													65	101					0	0	0.000781405	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40300312	40300312	+	Silent	SNP	C	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:40300312C>G	uc001zkm.1	+	25	3542	c.3492C>G	c.(3490-3492)GTC>GTG	p.V1164V	EIF2AK4_uc010bbj.1_Silent_p.V865V|EIF2AK4_uc001zkn.1_Silent_p.V264V|EIF2AK4_uc001zko.1_Silent_p.V102V|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1164	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		TTGATATTGTCACTTCTACCA	0.428													59	106					0	0	0.000781405	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40300332	40300332	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:40300332T>C	uc001zkm.1	+	25	3562	c.3512T>C	c.(3511-3513)TTT>TCT	p.F1171S	EIF2AK4_uc010bbj.1_Missense_Mutation_p.F872S|EIF2AK4_uc001zkn.1_Missense_Mutation_p.F271S|EIF2AK4_uc001zko.1_Missense_Mutation_p.F109S|EIF2AK4_uc010bbk.1_RNA	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	1171	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		ACCAACAGCTTTCTGCCCACT	0.418													63	118					0	0	0.000781405	0	0
DISP2	85455	broad.mit.edu	37	15	40657471	40657471	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:40657471C>T	uc001zlk.1	+	6	932	c.843C>T	c.(841-843)CCC>CCT	p.P281P		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	281					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		TCTGTGGCCCCCCTGGTAAGC	0.607													8	22					0	0	0.000157383	0	0
TYRO3	7301	broad.mit.edu	37	15	41854889	41854889	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:41854889C>T	uc001zof.1	+	4	777	c.553C>T	c.(553-555)CCC>TCC	p.P185S		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	185	Ig-like C2-type 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGGACCCGCTCCCTCTCCATC	0.567													5	10					0	0	0.000602214	0	0
SPTBN5	51332	broad.mit.edu	37	15	42171653	42171653	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:42171653A>G	uc001zos.2	-	16	3215	c.2882T>C	c.(2881-2883)CTG>CCG	p.L961P		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	996	Spectrin 7.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		ACTGTGTGCCAGCTGCACGGC	0.637													4	1					0	0	0.00024832	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42298225	42298225	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:42298225C>T	uc001zow.1	-	3	401	c.401G>A	c.(400-402)CGA>CAA	p.R134Q		NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	145					phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GGTTTTCTTTCGGAAACAGAG	0.507													14	39					0	0	0.00185496	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42363686	42363686	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:42363686C>T	uc001zox.2	-	16	1732	c.1637G>A	c.(1636-1638)GGG>GAG	p.G546E		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	546	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CCAGGACTCCCCAGAACTGGT	0.557													13	22					0	0	0.000308642	0	0
CATSPER2	117155	broad.mit.edu	37	15	43940220	43940221	+	Silent	DNP	GG	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:43940220_43940221GG>TT	uc001zsh.2	-	2	254_255	c.39_40CC>AA	c.(37-42)CCCCGA>CCAAGA	p.13_14PR>PR	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.13_14PR>PR|CATSPER2_uc001zsj.2_Silent_p.13_14PR>PR|CATSPER2_uc001zsk.2_Silent_p.13_14PR>PR|CATSPER2_uc001zsl.1_Intron	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	13_14	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		GCATCAGCTCGGGGAAGCTGCA	0.485													7	317					0	0	6.4e-05	0	0
CATSPER2	117155	broad.mit.edu	37	15	43940225	43940225	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:43940225A>G	uc001zsh.2	-	2	250	c.35T>C	c.(34-36)CTT>CCT	p.L12P	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Missense_Mutation_p.L12P|CATSPER2_uc001zsj.2_Missense_Mutation_p.L12P|CATSPER2_uc001zsk.2_Missense_Mutation_p.L12P|CATSPER2_uc001zsl.1_Intron	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	12	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		AGCTCGGGGAAGCTGCATCTG	0.488													109	217					0	0	0.000781405	0	0
PDIA3	2923	broad.mit.edu	37	15	44062493	44062493	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:44062493G>A	uc001zsu.2	+	11	1460	c.1312G>A	c.(1312-1314)GCC>ACC	p.A438T	PDIA3_uc010bdp.2_Missense_Mutation_p.A418T|PDIA3_uc010ued.1_Missense_Mutation_p.A212T	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	438	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		GGATGCCACAGCCAATGATGT	0.398													14	33					0	0	0.000566183	0	0
SHC4	399694	broad.mit.edu	37	15	49176514	49176514	+	Silent	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:49176514A>G	uc001zxb.1	-	4	1200	c.771T>C	c.(769-771)TTT>TTC	p.F257F		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	257	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TCATTCCTGAAAACTGAAGAT	0.323													29	52					0	0	0.00209593	0	0
TRPM7	54822	broad.mit.edu	37	15	50897179	50897179	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:50897179A>G	uc001zyt.3	-	21	3136	c.2872T>C	c.(2872-2874)TTT>CTT	p.F958L	TRPM7_uc010bew.1_Missense_Mutation_p.F958L|TRPM7_uc001zyu.2_Missense_Mutation_p.F516L	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	958	Extracellular (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		CCAGCCACAAAAACATGATTA	0.328													27	56					0	0	0.000878237	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350308	51350308	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:51350308A>T	uc001zyy.2	-	3	749	c.649T>A	c.(649-651)TTC>ATC	p.F217I		NM_207381	NP_997264	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein	217											0				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		TTCCTATCGAAGGTGTATTCC	0.547													18	40					0	0	0.000566183	0	0
GLDN	342035	broad.mit.edu	37	15	51696536	51696536	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:51696536G>A	uc002aba.2	+	10	1410	c.1241G>A	c.(1240-1242)CGA>CAA	p.R414Q	GLDN_uc002abb.2_Missense_Mutation_p.R290Q	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	414	Extracellular (Potential).|Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		TATTTTGATCGAAAATACCTT	0.373													62	88					0	0	0.000781405	0	0
GCOM1	145781	broad.mit.edu	37	15	57910263	57910263	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:57910263G>A	uc002aei.2	+	3	314	c.195G>A	c.(193-195)AGG>AGA	p.R65R	GCOM1_uc002aej.2_Silent_p.R65R|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Silent_p.R65R|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Silent_p.R65R|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	65					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AACCTACCAGGAAACTTCCTC	0.413													18	35					0	0	0.00229938	0	0
VPS13C	54832	broad.mit.edu	37	15	62205598	62205598	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:62205598G>A	uc002agz.2	-	62	8536	c.8462C>T	c.(8461-8463)TCA>TTA	p.S2821L	VPS13C_uc002aha.2_Missense_Mutation_p.S2778L|VPS13C_uc002ahb.1_Missense_Mutation_p.S2821L|VPS13C_uc002ahc.1_Missense_Mutation_p.S2778L|VPS13C_uc002ahd.1_Missense_Mutation_p.S198L	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2821					protein localization					ovary(2)	2						GGCACTGGTTGAAATTTTTAA	0.378													32	66					0	0	0.00058488	0	0
VPS13C	54832	broad.mit.edu	37	15	62214859	62214859	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:62214859G>A	uc002agz.2	-	54	6786	c.6712C>T	c.(6712-6714)CTT>TTT	p.L2238F	VPS13C_uc002aha.2_Missense_Mutation_p.L2195F|VPS13C_uc002ahb.1_Missense_Mutation_p.L2238F|VPS13C_uc002ahc.1_Missense_Mutation_p.L2195F	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2238					protein localization					ovary(2)	2						ATACCCCAAAGATTTTCCATT	0.363													36	78					0	0	0.00148497	0	0
TLN2	83660	broad.mit.edu	37	15	63058542	63058542	+	Missense_Mutation	SNP	C	T	T	rs142261304		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:63058542C>T	uc002alb.3	+	38	5117	c.5117C>T	c.(5116-5118)TCG>TTG	p.S1706L	TLN2_uc002alc.3_Missense_Mutation_p.S99L|TLN2_uc002ald.2_Missense_Mutation_p.S99L	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1706					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						CAGCTGACTTCGGTGGTCCAG	0.557													21	36					0	0	0.00229938	0	0
CYP11A1	1583	broad.mit.edu	37	15	74636166	74636166	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:74636166C>T	uc002axt.2	-	4	948	c.793G>A	c.(793-795)GAC>AAC	p.D265N	CYP11A1_uc002axs.2_Missense_Mutation_p.D107N|CYP11A1_uc010bjm.1_Missense_Mutation_p.D107N|CYP11A1_uc010bjn.1_Intron|CYP11A1_uc010bjo.1_Missense_Mutation_p.D265N|CYP11A1_uc010bjp.1_RNA|CYP11A1_uc010ulj.1_Missense_Mutation_p.D45N	NM_000781	NP_000772	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A,	265					C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			ovary(2)	2					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GCCACATGGTCCTTCCAGGTC	0.577													72	107					0	0	0.000781405	0	0
CYP1A2	1544	broad.mit.edu	37	15	75047291	75047291	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:75047291C>T	uc002ayr.1	+	7	1477	c.1413C>T	c.(1411-1413)TTC>TTT	p.F471F		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	471					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	TCTTCCTCTTCCTGGCCATCC	0.592													23	37					0	0	0.000586117	0	0
SGK269	79834	broad.mit.edu	37	15	77474242	77474242	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:77474242T>C	uc002bcm.2	-	3	335	c.27A>G	c.(25-27)GAA>GAG	p.E9E	SGK269_uc002bcn.2_Silent_p.E9E	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	9					cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TCCAAACATGTTCAGTAAAGG	0.398													34	43					0	0	0.00058488	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921508	78921508	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:78921508G>A	uc002bed.1	-	5	1251	c.1139C>T	c.(1138-1140)TCC>TTC	p.S380F	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.S198F	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	380	Cytoplasmic (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						ATAGAAGTTGGAGGGGCTGGT	0.642													21	23					0	0	0.00188189	0	0
KIAA1024	23251	broad.mit.edu	37	15	79755596	79755596	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:79755596C>T	uc002bew.1	+	3	2561	c.2486C>T	c.(2485-2487)TCT>TTT	p.S829F	KIAA1024_uc010unk.1_Missense_Mutation_p.S829F	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	829						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						GGCCAACCTTCTTGGACCATT	0.627													38	43					0	0	0.00148497	0	0
TMC3	342125	broad.mit.edu	37	15	81650587	81650587	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:81650587C>T	uc002bgo.1	-	7	646	c.646G>A	c.(646-648)GAG>AAG	p.E216K	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Missense_Mutation_p.E216K	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	216	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						ATCTTCCTCTCCCTGCCGTAA	0.493													31	47					0	0	0.000953801	0	0
EFTUD1	79631	broad.mit.edu	37	15	82456243	82456243	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:82456243G>A	uc002bgt.1	-	16	2002	c.1833C>T	c.(1831-1833)AAC>AAT	p.N611N	EFTUD1_uc002bgu.1_Silent_p.N560N	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	611					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TGGCTTCGAAGTTGAGTGGTA	0.388													12	32					0	0	0.000219431	0	0
BTBD1	53339	broad.mit.edu	37	15	83725214	83725214	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:83725214G>A	uc002bjn.2	-	2	688	c.485C>T	c.(484-486)GCC>GTC	p.A162V	BTBD1_uc002bjo.2_Missense_Mutation_p.A162V	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	162						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		TGCTTCCAAGGCTGGGACTGC	0.378													23	30					0	0	0.00229938	0	0
SEMA4B	10509	broad.mit.edu	37	15	90764258	90764258	+	Silent	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:90764258C>A	uc002boy.2	+	6	811	c.528C>A	c.(526-528)GTC>GTA	p.V176V	SEMA4B_uc002boz.2_Silent_p.V176V|SEMA4B_uc010uqd.1_Silent_p.V14V|SEMA4B_uc002bpa.2_Silent_p.V14V|SEMA4B_uc010bnv.1_5'Flank	NM_020210	NP_064595			semaphorin 4B precursor											ovary(1)|breast(1)|kidney(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0125)|all_lung(78;0.0272)		BRCA - Breast invasive adenocarcinoma(143;0.0107)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.217)			AGGGGAATGTCCTCCTGGAAG	0.582													5	2					4.096e-09	1.70747e-08	0.00116845	1	0
IQGAP1	8826	broad.mit.edu	37	15	90984750	90984750	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:90984750T>C	uc002bpl.1	+	8	763	c.662T>C	c.(661-663)GTT>GCT	p.V221A		NM_003870	NP_003861	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	221					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			ovary(2)|lung(2)|central_nervous_system(2)|pancreas(1)|skin(1)	8	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CATGCTGCTGTTATTGCTATT	0.348													29	34					0	0	0.00178596	0	0
BLM	641	broad.mit.edu	37	15	91333908	91333909	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:91333908_91333909GG>TT	uc002bpr.2	+	15	2950_2951	c.2853_2854GG>TT	c.(2851-2856)ATGGGG>ATTTGG	p.951_952MG>IW	BLM_uc010uqh.1_Missense_Mutation_p.951_952MG>IW|BLM_uc010uqi.1_Missense_Mutation_p.576_577MG>IW|BLM_uc010bnx.2_Missense_Mutation_p.951_952MG>IW|BLM_uc002bps.1_Missense_Mutation_p.513_514MG>IW	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	951_952	Helicase C-terminal.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			CATTTGGAATGGGGATTGACAA	0.411			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				10	428					0	0	6.4e-05	0	0
SV2B	9899	broad.mit.edu	37	15	91810814	91810815	+	Missense_Mutation	DNP	GG	TT	TT	rs146252262	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:91810814_91810815GG>TT	uc002bqv.2	+	7	1540_1541	c.1149_1150GG>TT	c.(1147-1152)ATGGGG>ATTTGG	p.383_384MG>IW	SV2B_uc002bqt.2_Missense_Mutation_p.383_384MG>IW|SV2B_uc010uqv.1_Missense_Mutation_p.232_233MG>IW|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	383_384	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			ACTGTGTGATGGGGCCCTACAG	0.45													14	448					0	0	6.4e-05	0	0
MCTP2	55784	broad.mit.edu	37	15	94983482	94983482	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:94983482C>T	uc002btj.2	+	17	2228	c.2163C>T	c.(2161-2163)TTC>TTT	p.F721F	MCTP2_uc010boj.2_Silent_p.F450F|MCTP2_uc010bok.2_Intron|MCTP2_uc002btl.2_Silent_p.F309F	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	721					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TCTACAATTTCATCAGACCTG	0.403													53	83					0	0	0.000781405	0	0
LRRC28	123355	broad.mit.edu	37	15	99892588	99892588	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:99892588C>T	uc002bva.1	+	7	762	c.607C>T	c.(607-609)CGA>TGA	p.R203*	LRRC28_uc010urs.1_RNA|LRRC28_uc002bvb.1_Nonsense_Mutation_p.R49*|LRRC28_uc010urt.1_Nonsense_Mutation_p.R17*|LRRC28_uc002bvc.1_Nonsense_Mutation_p.R203*|LRRC28_uc010uru.1_Nonsense_Mutation_p.R134*|LRRC28_uc002bvd.1_Intron	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	203											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			AGGTCGATCTCGAGAACTACA	0.353													62	78					0	0	0.000781405	0	0
OR4F15	390649	broad.mit.edu	37	15	102358668	102358668	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:102358668C>T	uc010uts.1	+	1	279	c.279C>T	c.(277-279)TCC>TCT	p.S93S		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			AGGCCATCTCCTTTCGGGGAT	0.443													38	64					0	0	0.000953801	0	0
MSLN	10232	broad.mit.edu	37	16	815762	815762	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:815762C>T	uc002cjw.1	+	10	918	c.867C>T	c.(865-867)CTC>CTT	p.L289L	MSLN_uc002cjt.1_Silent_p.L289L|MSLN_uc002cju.1_Silent_p.L289L|MSLN_uc010brd.1_Silent_p.L288L|MSLN_uc002cjv.1_Silent_p.L289L|MSLN_uc002cjx.1_Silent_p.L289L|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	289					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GGACCATCCTCCGGCCGCGGT	0.701													10	15					0	0	0.000673444	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291284	1291284	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:1291284C>T	uc002ckz.2	+	3	244	c.192C>T	c.(190-192)ATC>ATT	p.I64I	TPSAB1_uc010uux.1_Silent_p.I9I	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	64	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GCTCCCTCATCCACCCCCAGT	0.701													12	31					0	0	0.000219431	0	0
ABCA3	21	broad.mit.edu	37	16	2345602	2345602	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:2345602C>T	uc002cpy.1	-	18	3115	c.2403G>A	c.(2401-2403)GAG>GAA	p.E801E	ABCA3_uc010bsk.1_Silent_p.E743E|ABCA3_uc010bsl.1_Silent_p.E801E	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	801			E -> D (in a breast cancer sample; somatic mutation).		response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.E801D(1)		breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TGTGCGTGCTCTCTCTGGGAA	0.627													50	84					0	0	0.000781405	0	0
SRRM2	23524	broad.mit.edu	37	16	2812815	2812815	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:2812815C>T	uc002crk.2	+	11	2835	c.2286C>T	c.(2284-2286)CTC>CTT	p.L762L	SRRM2_uc002crj.1_Silent_p.L666L|SRRM2_uc002crl.1_Silent_p.L762L|SRRM2_uc010bsu.1_Silent_p.L666L	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	762	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCAGGTCTCTCTCTTCACCAC	0.488													49	96					0	0	0.000781405	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857332	9857332	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:9857332G>A	uc002czo.3	-	13	4617	c.4069C>T	c.(4069-4071)CTC>TTC	p.L1357F	GRIN2A_uc010uym.1_Missense_Mutation_p.L1357F|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1357	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTGGCAAGAGAGACTTGCTC	0.532													18	41					0	0	0.000566183	0	0
GRIN2A	2903	broad.mit.edu	37	16	10032408	10032408	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:10032408C>T	uc002czo.3	-	3	963	c.415G>A	c.(415-417)GAT>AAT	p.D139N	GRIN2A_uc010uym.1_Missense_Mutation_p.D139N|GRIN2A_uc010uyn.1_5'UTR|GRIN2A_uc002czr.3_Missense_Mutation_p.D139N	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	139	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GACGTCGGATCCTGCCAGTGA	0.463													18	25					0	0	0.00074312	0	0
CLEC16A	23274	broad.mit.edu	37	16	11219974	11219974	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:11219974C>T	uc002dao.2	+	22	2842	c.2612C>T	c.(2611-2613)TCC>TTC	p.S871F	CLEC16A_uc002dan.3_Missense_Mutation_p.S853F|CLEC16A_uc002dap.2_5'UTR	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	871										ovary(1)|central_nervous_system(1)	2						GTGCAGCGCTCCGTGTTTGCA	0.652													13	25					0	0	0.00185496	0	0
KIAA0430	9665	broad.mit.edu	37	16	15724341	15724341	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:15724341C>T	uc002ddr.2	-	7	1565	c.1372G>A	c.(1372-1374)GAA>AAA	p.E458K	KIAA0430_uc002ddq.2_Missense_Mutation_p.E457K|KIAA0430_uc010uzv.1_Missense_Mutation_p.E454K|KIAA0430_uc010uzw.1_Missense_Mutation_p.E457K	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	457						peroxisome	nucleotide binding|RNA binding				0						TCACTAAGTTCCAATGCAAAA	0.438													25	23					0	0	0.000878237	0	0
ABCC6	368	broad.mit.edu	37	16	16284138	16284138	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:16284138C>T	uc002den.3	-	12	1555	c.1518G>A	c.(1516-1518)TGG>TGA	p.W506*	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Nonsense_Mutation_p.W518*	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	506	ABC transmembrane type-1 1.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.W506*(1)		skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		AGGCTCCCTCCCAGCCATGGA	0.622													23	32					0	0	0.00047179	0	0
C16orf88	400506	broad.mit.edu	37	16	19726093	19726093	+	Missense_Mutation	SNP	G	A	A	rs146629491	by1000genomes	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:19726093G>A	uc002dgq.2	-	2	280	c.265C>T	c.(265-267)CCT>TCT	p.P89S	IQCK_uc002dgr.2_5'Flank|IQCK_uc002dgs.2_5'Flank|IQCK_uc010vat.1_5'Flank|IQCK_uc010bwc.2_5'Flank|IQCK_uc010vau.1_5'Flank	NM_001012991	NP_001013009	Q1ED39	CP088_HUMAN	hypothetical protein LOC400506	89	Lys-rich.					nucleolus					0						CGTCTAGCAGGCAGCGTGGTC	0.478													22	44					0	0	0.00047179	0	0
DNAH3	55567	broad.mit.edu	37	16	20952789	20952789	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:20952789A>T	uc010vbe.1	-	59	11588	c.11588T>A	c.(11587-11589)TTG>TAG	p.L3863*	DNAH3_uc010vbd.1_Nonsense_Mutation_p.L1298*	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3863					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CACGGGGTACAACTTCATGAC	0.488													71	95					0	0	0.000781405	0	0
DCTN5	84516	broad.mit.edu	37	16	23672571	23672571	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:23672571C>T	uc002dly.1	+	4	374	c.317C>T	c.(316-318)TCC>TTC	p.S106F		NM_032486	NP_115875	Q9BTE1	DCTN5_HUMAN	dynactin 5	106						centrosome	transferase activity			upper_aerodigestive_tract(1)	1				GBM - Glioblastoma multiforme(48;0.0156)		CAGATTGGTTCCTATGTTCAT	0.443													26	38					0	0	0.0024448	0	0
ERN2	10595	broad.mit.edu	37	16	23718180	23718180	+	Missense_Mutation	SNP	G	A	A	rs148177655	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:23718180G>A	uc002dma.3	-	6	695	c.526C>T	c.(526-528)CGG>TGG	p.R176W	ERN2_uc010bxp.2_Missense_Mutation_p.R176W|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	128	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TCCTGCTTCCGGCCTGTGGAG	0.592													21	21					0	0	0.00121646	0	0
PRKCB	5579	broad.mit.edu	37	16	24185843	24185843	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:24185843T>C	uc002dmd.2	+	12	1533	c.1336T>C	c.(1336-1338)TAC>CAC	p.Y446H	PRKCB_uc002dme.2_Missense_Mutation_p.Y446H	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	446	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TTTCAGATTTTACGCTGCAGA	0.388													13	25					0	0	0.000219431	0	0
HS3ST4	9951	broad.mit.edu	37	16	26147380	26147380	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:26147380C>T	uc002dof.2	+	2	1574	c.1182C>T	c.(1180-1182)TTC>TTT	p.F394F		NM_006040	NP_006031	Q9Y661	HS3S4_HUMAN	heparan sulfate D-glucosaminyl	394	Lumenal (Potential).				heparan sulfate proteoglycan metabolic process	extracellular region|Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			large_intestine(1)|breast(1)	2				GBM - Glioblastoma multiforme(48;0.0988)		CCAAGGGGTTCCCTTGCCTAA	0.512													14	11					0	0	0.000219431	0	0
XPO6	23214	broad.mit.edu	37	16	28146632	28146632	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:28146632G>A	uc002dpa.1	-	10	1849	c.1348C>T	c.(1348-1350)CTG>TTG	p.L450L	XPO6_uc002dpb.1_Silent_p.L436L|XPO6_uc010vcp.1_Silent_p.L450L	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	450					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						AGGAGCACCAGGGCATCTTCG	0.463													35	70					0	0	0.00111076	0	0
APOB48R	55911	broad.mit.edu	37	16	28509438	28509439	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:28509438_28509439CC>TT	uc002dqb.1	+	4	2975_2976	c.2965_2966CC>TT	c.(2965-2967)CCA>TTA	p.P989L	uc010vct.1_Intron|APOB48R_uc010byg.1_Missense_Mutation_p.P527L	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	989					cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						CGTCTCTGTCCCAAGGAGTCGC	0.688													6	18					0	0	6.4e-05	0	0
SEPT1	1731	broad.mit.edu	37	16	30392719	30392719	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:30392719C>G	uc002dxy.2	-	6	568	c.381G>C	c.(379-381)AAG>AAC	p.K127N	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_5'UTR|SEPT1_uc010veq.1_Missense_Mutation_p.K174N	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	127					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			CCTGGATGTTCTTCCGGTTCA	0.597													25	41					0	0	0.000878237	0	0
SRCAP	10847	broad.mit.edu	37	16	30750282	30750282	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:30750282C>T	uc002dze.1	+	34	9306	c.8921C>T	c.(8920-8922)CCC>CTC	p.P2974L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.P2769L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2974	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CACCCATCACCCCTAACCCCA	0.577													15	11					0	0	0.000566183	0	0
RNF40	9810	broad.mit.edu	37	16	30777523	30777523	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:30777523C>T	uc002dzq.2	+	9	1156	c.1033C>T	c.(1033-1035)CTG>TTG	p.L345L	RNF40_uc010caa.2_Silent_p.L345L|RNF40_uc010cab.2_Intron|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Silent_p.L345L|RNF40_uc010vfb.1_Intron|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	345	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			AAACCAGGAACTGGCCAACAG	0.602													26	59					0	0	0.000586117	0	0
FBXL19	54620	broad.mit.edu	37	16	30939897	30939897	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:30939897C>T	uc002eab.2	+	6	955	c.797C>T	c.(796-798)CCG>CTG	p.P266L	FBXL19_uc002dzz.1_5'UTR|FBXL19_uc002eaa.1_Intron	NM_001099784	NP_001093254	Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	266	Pro-rich.						DNA binding|zinc ion binding			ovary(2)|lung(1)|breast(1)	4						GTTCTGAATCCGAGCCAGGCT	0.692													4	7					0	0	0.00116845	0	0
FUS	2521	broad.mit.edu	37	16	31202393	31202393	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:31202393G>A	uc002ebf.2	+	14	1586	c.1503G>A	c.(1501-1503)GGG>GGA	p.G501G	FUS_uc002ebh.2_Silent_p.G500G|FUS_uc002ebg.2_Silent_p.G296G|FUS_uc002ebi.2_Silent_p.G502G|FUS_uc002ebj.2_Silent_p.G297G	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	501	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		GGGGTGGTGGGGACAGAGGTG	0.592			T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								13	32					0	0	0.00185496	0	0
ITGAD	3681	broad.mit.edu	37	16	31424248	31424248	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:31424248G>A	uc002ebv.1	+	15	1846	c.1797G>A	c.(1795-1797)ATG>ATA	p.M599I	ITGAD_uc010cap.1_Missense_Mutation_p.M600I	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	599	Potential.|Extracellular (Potential).|FG-GAP 7.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						ATGGACTGATGGACCTGGCCG	0.667													26	29					0	0	0.00106085	0	0
Unknown	0	broad.mit.edu	37	16	33784746	33784746	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:33784746C>T	uc010vgb.1	+	2	155	c.135C>T	c.(133-135)GCC>GCT	p.A45A						RecName: Full=Transporter;																		TGGGCTGGGCCTTCGTGCTGT	0.617													10	26					0	0	0.00136819	0	0
MYLK3	91807	broad.mit.edu	37	16	46774025	46774025	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:46774025G>A	uc002eei.3	-	2	628	c.512C>T	c.(511-513)CCA>CTA	p.P171L	MYLK3_uc010vge.1_5'UTR|MYLK3_uc002eej.1_5'Flank	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	171					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CACATGCTTTGGTTTTCCTCC	0.448													50	63					0	0	0.000781405	0	0
NETO2	81831	broad.mit.edu	37	16	47162260	47162260	+	Nonsense_Mutation	SNP	G	A	A	rs144229750	by1000genomes	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:47162260G>A	uc002eer.1	-	4	842	c.457C>T	c.(457-459)CGA>TGA	p.R153*	NETO2_uc010vgf.1_Nonsense_Mutation_p.R17*|NETO2_uc002ees.1_Nonsense_Mutation_p.R153*	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	153	Extracellular (Potential).|CUB 1.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				TATTTTGCTCGAAATCCCAGT	0.363										HNSCC(25;0.065)			32	48					0	0	0.00209593	0	0
ABCC12	94160	broad.mit.edu	37	16	48142409	48142409	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:48142409G>A	uc002efc.1	-	17	2659	c.2313C>T	c.(2311-2313)TCC>TCT	p.S771S	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	771						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CTTCCTGGGGGGATTCAGTCT	0.502													43	50					0	0	0.000781405	0	0
HEATR3	55027	broad.mit.edu	37	16	50136199	50136199	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:50136199C>T	uc002efw.2	+	14	1935	c.1773C>T	c.(1771-1773)ACC>ACT	p.T591T	HEATR3_uc002efx.2_Silent_p.T505T	NM_182922	NP_891552	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	591							binding			ovary(1)|skin(1)	2						TTGAAGTTACCACCAAAGATC	0.418													29	67					0	0	0.00178596	0	0
SALL1	6299	broad.mit.edu	37	16	51175771	51175771	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:51175771C>T	uc010vgs.1	-	2	393	c.362G>A	c.(361-363)AGG>AAG	p.R121K	SALL1_uc010vgr.1_Missense_Mutation_p.R24K|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	121					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGACTCTTCCCTGTCAAGTCC	0.502													23	68					0	0	0.000878237	0	0
LPCAT2	54947	broad.mit.edu	37	16	55584910	55584910	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:55584910G>T	uc002eie.3	+	11	1292	c.1111G>T	c.(1111-1113)GCG>TCG	p.A371S	LPCAT2_uc002eic.2_Missense_Mutation_p.A101S	NM_017839	NP_060309	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	371	Lumenal (Potential).				cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding				0						TGCATCTATTGCGAGTTCCTC	0.348													37	60					6.53348e-20	2.72995e-19	0.000692331	1	0
NUP93	9688	broad.mit.edu	37	16	56866247	56866247	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:56866247C>T	uc002eka.2	+	12	1413	c.1292C>T	c.(1291-1293)CCA>CTA	p.P431L	NUP93_uc002ekb.2_Missense_Mutation_p.P308L|NUP93_uc010vhi.1_Missense_Mutation_p.P308L	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	431					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						ACCAGCTCCCCACAAGACAGG	0.473													21	51					0	0	0.000720815	0	0
PLLP	51090	broad.mit.edu	37	16	57295862	57295862	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:57295862G>A	uc002elg.1	-	2	384	c.256C>T	c.(256-258)CTC>TTC	p.L86F		NM_015993	NP_057077	Q9Y342	PLLP_HUMAN	plasmolipin	86	Helical; (Potential).|MARVEL.					integral to membrane	ion channel activity				0						AACAGGTAGAGGTTGAAGAGG	0.567													22	32					0	0	0.000375601	0	0
CCDC102A	92922	broad.mit.edu	37	16	57562890	57562891	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:57562890_57562891CC>TT	uc002elw.2	-	2	412_413	c.199_200GG>AA	c.(199-201)GGC>AAC	p.G67N		NM_033212	NP_149989	Q96A19	C102A_HUMAN	coiled-coil domain containing 102A	67										ovary(1)	1						CTCCCAGTCGCCGTCGGCCAGC	0.47													6	4					0	0	6.4e-05	0	0
PRSS54	221191	broad.mit.edu	37	16	58319856	58319856	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:58319856C>T	uc002enf.2	-	5	902	c.507G>A	c.(505-507)TGG>TGA	p.W169*	PRSS54_uc002eng.2_Nonsense_Mutation_p.W169*|PRSS54_uc010vie.1_Nonsense_Mutation_p.W70*	NM_001080492	NP_001073961	Q6PEW0	PRS54_HUMAN	plasma kallikrein-like protein 4 precursor	169	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ATGTGGGATTCCATCCTGACA	0.537													23	33					0	0	0.000586117	0	0
NDRG4	65009	broad.mit.edu	37	16	58538325	58538325	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:58538325G>A	uc002eno.2	+	4	417	c.311G>A	c.(310-312)GGG>GAG	p.G104E	NDRG4_uc002enk.2_Missense_Mutation_p.G136E|NDRG4_uc002enm.2_Missense_Mutation_p.G156E|NDRG4_uc010vif.1_Missense_Mutation_p.G136E|NDRG4_uc010cdk.2_Missense_Mutation_p.G122E|NDRG4_uc010vig.1_Missense_Mutation_p.G134E|NDRG4_uc010vih.1_Missense_Mutation_p.G49E|NDRG4_uc010vii.1_Missense_Mutation_p.G122E|NDRG4_uc002enp.2_Missense_Mutation_p.G104E|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	104					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						CAGCATTTCGGGTGAGTCCCC	0.682													24	33					0	0	0.001512	0	0
CNOT1	23019	broad.mit.edu	37	16	58557398	58557398	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:58557398G>A	uc002env.2	-	47	7086	c.6793C>T	c.(6793-6795)CTC>TTC	p.L2265F	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.L2260F|CNOT1_uc002ent.2_Missense_Mutation_p.L203F|CNOT1_uc010vik.1_Missense_Mutation_p.L1222F	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2265					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTCAAAAAGAGATAGCGACCT	0.443													30	43					0	0	0.00209593	0	0
CDH16	1014	broad.mit.edu	37	16	66948290	66948290	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:66948290C>T	uc002eql.2	-	7	682	c.609G>A	c.(607-609)CTG>CTA	p.L203L	CDH16_uc010cdy.2_Silent_p.L203L|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	203	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		AGGTCCTCTCCAGGGCGTGGT	0.607													10	19					0	0	0.000673444	0	0
FAM65A	79567	broad.mit.edu	37	16	67576106	67576106	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:67576106C>T	uc010vjp.1	+	13	1573	c.1477C>T	c.(1477-1479)CTA>TTA	p.L493L	FAM65A_uc010cei.1_Silent_p.L315L|FAM65A_uc002eth.2_Silent_p.L473L|FAM65A_uc010cej.2_Silent_p.L476L|FAM65A_uc002eti.1_Silent_p.L436L|FAM65A_uc010vjq.1_Silent_p.L487L|FAM65A_uc002etj.1_Silent_p.L472L|FAM65A_uc002etk.2_Silent_p.L472L	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567	477						cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CCCAGAAAGCCTAGCCTGGGG	0.622													20	37					0	0	0.000958276	0	0
WWP2	11060	broad.mit.edu	37	16	69951744	69951744	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:69951744C>T	uc002exu.1	+	11	1226	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	WWP2_uc002exv.1_Silent_p.L379L|WWP2_uc010vlm.1_Silent_p.L263L|WWP2_uc010vln.1_5'UTR	NM_007014	NP_008945	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase	379					entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			lung(3)|ovary(1)|breast(1)|skin(1)	6						GGAATCAGCTCCAGGGGGCCA	0.617													6	20					0	0	0.000157383	0	0
ZNF19	7567	broad.mit.edu	37	16	71509231	71509231	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:71509231G>A	uc010cgc.1	-	6	1725	c.1219C>T	c.(1219-1221)CAT>TAT	p.H407Y	ZNF23_uc002fai.2_Intron|ZNF19_uc002fak.1_Missense_Mutation_p.H395Y|ZNF19_uc002fal.1_Missense_Mutation_p.H395Y|ZNF19_uc002fam.1_Missense_Mutation_p.H407Y	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	407	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		TCTCCAGTATGGATTCTTTGA	0.443													26	44					0	0	0.00047179	0	0
ZFHX3	463	broad.mit.edu	37	16	72827786	72827786	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:72827786C>T	uc002fck.2	-	9	9468	c.8795G>A	c.(8794-8796)GGA>GAA	p.G2932E	ZFHX3_uc002fcl.2_Missense_Mutation_p.G2018E	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2932					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GCCTGCAGATCCACTCGCACC	0.512													29	41					0	0	0.00111076	0	0
NUDT7	283927	broad.mit.edu	37	16	77775602	77775602	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:77775602C>T	uc010chd.2	+	4	541	c.472C>T	c.(472-474)CAT>TAT	p.H158Y	NUDT7_uc010vnj.1_Missense_Mutation_p.H105Y	NM_001105663	NP_001099133	P0C024	NUDT7_HUMAN	nudix motif 7	158	Nudix hydrolase.				nucleoside diphosphate metabolic process	peroxisome	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|magnesium ion binding|manganese ion binding			ovary(1)|kidney(1)	2						TCCACAGGTCCATGACCAGCA	0.468													36	60					0	0	0.00195071	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033683	82033683	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:82033683T>C	uc002fgu.2	-	3	343	c.215A>G	c.(214-216)GAC>GGC	p.D72G		NM_145168	NP_660151	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E,	72					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding				0						ACAAGTGACGTCTGCATCCTG	0.493													52	57					0	0	0.000781405	0	0
ZNF276	92822	broad.mit.edu	37	16	89789072	89789072	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr16:89789072C>T	uc002fos.3	+	2	436	c.339C>T	c.(337-339)CTC>CTT	p.L113L	C16orf7_uc002fol.1_5'Flank|C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Silent_p.L38L|ZNF276_uc002foq.3_Silent_p.L38L|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	113	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		AGCGCGTGCTCGTACGGGACT	0.647													17	36					0	0	0.00121646	0	0
RPH3AL	9501	broad.mit.edu	37	17	97003	97003	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:97003C>T	uc002frd.1	-	5	556	c.512G>A	c.(511-513)CGA>CAA	p.R171Q	RPH3AL_uc010vpy.1_Missense_Mutation_p.R171Q|RPH3AL_uc002fre.1_Missense_Mutation_p.R171Q|RPH3AL_uc002frf.1_Missense_Mutation_p.R142Q|RPH3AL_uc010cjl.1_Missense_Mutation_p.R142Q	NM_006987	NP_008918	Q9UNE2	RPH3L_HUMAN	rabphilin 3A-like (without C2 domains)	171					exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)		GTCATCAGCTCGGCCAGGGGT	0.622													12	25					0	0	0.00136819	0	0
ABR	29	broad.mit.edu	37	17	914039	914039	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:914039C>T	uc002fsd.2	-	20	2276	c.2166G>A	c.(2164-2166)AAG>AAA	p.K722K	ABR_uc002fse.2_Silent_p.K676K|ABR_uc010vqf.1_Silent_p.K173K|ABR_uc010vqg.1_Silent_p.K504K|ABR_uc002fsg.2_Silent_p.K685K|ABR_uc002fsh.1_Silent_p.K330K|ABR_uc002fsf.2_Silent_p.K259K	NM_021962	NP_068781	Q12979	ABR_HUMAN	active breakpoint cluster region-related	722	Rho-GAP.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0228)		GGAAGTACAGCTTGAGCGTCC	0.627													25	45					0	0	0.000375601	0	0
OR1G1	8390	broad.mit.edu	37	17	3030567	3030567	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:3030567G>A	uc002fvc.1	-	1	279	c.279C>T	c.(277-279)TCC>TCT	p.S93S		NM_003555	NP_003546	P47890	OR1G1_HUMAN	olfactory receptor, family 1, subfamily G,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCCTGAGTAGGAGATGGCCT	0.483													21	37					0	0	0.00188189	0	0
ARRB2	409	broad.mit.edu	37	17	4621234	4621234	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:4621234C>T	uc002fyj.2	+	8	765	c.537C>T	c.(535-537)CCC>CCT	p.P179P	ARRB2_uc002fyk.2_Silent_p.P164P|ARRB2_uc002fyl.2_Silent_p.P179P|ARRB2_uc010vsg.1_Silent_p.P200P|ARRB2_uc002fym.2_Silent_p.P164P|ARRB2_uc002fyn.2_5'UTR|ARRB2_uc010ckq.2_5'UTR|ARRB2_uc002fyo.2_5'UTR	NM_004313	NP_004304	P32121	ARRB2_HUMAN	arrestin, beta 2 isoform 1	179					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding				0						CGGAGAAACCCGGCCCCCAGC	0.637													7	18					0	0	0.00198382	0	0
RABEP1	9135	broad.mit.edu	37	17	5212019	5212019	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:5212019A>T	uc002gbm.3	+	2	289	c.65A>T	c.(64-66)GAA>GTA	p.E22V	RABEP1_uc010clc.1_Missense_Mutation_p.E22V|RABEP1_uc010cld.1_Intron|RABEP1_uc010vsw.1_Intron|RABEP1_uc002gbl.3_Missense_Mutation_p.E22V|RABEP1_uc002gbj.2_Missense_Mutation_p.E22V|RABEP1_uc002gbk.2_Missense_Mutation_p.E22V	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	22	Potential.				apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						GCAGAATTGGAAAAAATTAAT	0.303													15	22					0	0	0.000308642	0	0
WSCD1	23302	broad.mit.edu	37	17	5998538	5998538	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:5998538C>T	uc010cli.2	+	5	1223	c.844C>T	c.(844-846)CAG>TAG	p.Q282*	WSCD1_uc002gcn.2_Nonsense_Mutation_p.Q282*|WSCD1_uc002gco.2_Nonsense_Mutation_p.Q282*|WSCD1_uc010clj.2_5'UTR	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1	282	WSC 2.					integral to membrane	sulfotransferase activity				0						CTTTTGTTCCCAGAAAGTAAG	0.562													9	15					0	0	0.000274275	0	0
C17orf74	201243	broad.mit.edu	37	17	7330098	7330098	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:7330098C>T	uc002ggw.2	+	3	861	c.788C>T	c.(787-789)TCC>TTC	p.S263F	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	263						integral to membrane					0		Prostate(122;0.157)				CGCCACGGTTCCCAATCCCGA	0.662													15	16					0	0	0.000422831	0	0
DNAH2	146754	broad.mit.edu	37	17	7668873	7668873	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:7668873C>T	uc002giu.1	+	20	3515	c.3501C>T	c.(3499-3501)TTC>TTT	p.F1167F		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	1167	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				TGGAAGATTTCGAATTCAAAG	0.483													21	41					0	0	0.00047179	0	0
KCNAB3	9196	broad.mit.edu	37	17	7827774	7827774	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:7827774G>A	uc002gjm.1	-	9	670	c.670C>T	c.(670-672)CTA>TTA	p.L224L	KCNAB3_uc010vul.1_RNA	NM_004732	NP_004723	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related	224						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(1)	1		Prostate(122;0.157)				CCCCAGTATAGGGCCAGGCCC	0.557													16	28					0	0	0.00074312	0	0
ALOX12B	242	broad.mit.edu	37	17	7979013	7979013	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:7979013G>A	uc002gjy.1	-	12	1815	c.1554C>T	c.(1552-1554)ACC>ACT	p.T518T		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	518	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						GGTAATAATAGGTGATGATCT	0.587										Multiple Myeloma(8;0.094)			51	94					0	0	0.000781405	0	0
ALOX12B	242	broad.mit.edu	37	17	7989457	7989457	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:7989457A>T	uc002gjy.1	-	2	490	c.229T>A	c.(229-231)TTC>ATC	p.F77I	hsa-mir-4314|MI0015846_5'Flank	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	77	PLAT.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						TCCTTGGGGAAGAAGGCGTAC	0.592										Multiple Myeloma(8;0.094)			12	27					0	0	0.000978159	0	0
PFAS	5198	broad.mit.edu	37	17	8159960	8159960	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:8159960C>T	uc002gkr.2	+	8	1081	c.940C>T	c.(940-942)CCC>TCC	p.P314S	PFAS_uc010vuv.1_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	314					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCACAACTTTCCCACAGGTGA	0.562													22	23					0	0	0.000586117	0	0
PFAS	5198	broad.mit.edu	37	17	8167625	8167625	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:8167625C>T	uc002gkr.2	+	16	2028	c.1887C>T	c.(1885-1887)CTC>CTT	p.L629L	PFAS_uc010vuv.1_Silent_p.L205L|PFAS_uc010cnw.1_Silent_p.L129L|PFAS_uc002gks.2_5'Flank	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	629					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	ACCTGGAGCTCGAATGGGTGC	0.587													11	14					0	0	0.000978159	0	0
PFAS	5198	broad.mit.edu	37	17	8169316	8169316	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:8169316C>T	uc002gkr.2	+	21	2823	c.2682C>T	c.(2680-2682)ATC>ATT	p.I894I	PFAS_uc010vuv.1_Silent_p.I470I|PFAS_uc002gks.2_5'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	894					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCTTCAGCATCACTCAGGGGC	0.627													18	22					0	0	0.00074312	0	0
CCDC42	146849	broad.mit.edu	37	17	8644940	8644940	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:8644940C>T	uc002gln.2	-	4	571	c.344G>A	c.(343-345)CGA>CAA	p.R115Q	CCDC42_uc002glo.2_Missense_Mutation_p.R115Q	NM_144681	NP_653282	Q96M95	CCD42_HUMAN	coiled-coil domain containing 42 isoform 1	115	Potential.									ovary(1)	1						CTTGAGTTCTCGCTCCTTGTT	0.652													15	21					0	0	0.000422831	0	0
GLP2R	9340	broad.mit.edu	37	17	9737139	9737139	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:9737139C>T	uc002gmd.1	+	2	205	c.205C>T	c.(205-207)CTT>TTT	p.L69F	GLP2R_uc010cog.1_RNA	NM_004246	NP_004237	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor precursor	69	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				lung(2)|ovary(1)	3					Glucagon recombinant(DB00040)	AGGATCCCTCCTTGAGGAAAC	0.443													12	20					0	0	0.000308642	0	0
MYH1	4619	broad.mit.edu	37	17	10399579	10399579	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:10399579C>T	uc002gmo.2	-	34	5038	c.4944G>A	c.(4942-4944)AGG>AGA	p.R1648R	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1648	Potential.			R -> Q (in Ref. 4; CAA27380).		muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CTTGGGTGTTCCTATAGTTCC	0.498													29	63					0	0	0.000491102	0	0
DNAH9	1770	broad.mit.edu	37	17	11666769	11666769	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:11666769C>T	uc002gne.2	+	36	7076	c.7008C>T	c.(7006-7008)ATC>ATT	p.I2336I	DNAH9_uc010coo.2_Silent_p.I1630I	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2336					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTAAGAAGATCATTCCCATCC	0.498													45	81					0	0	0.000781405	0	0
ZSWIM7	125150	broad.mit.edu	37	17	15884382	15884382	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:15884382G>A	uc002gpe.2	-	4	376	c.278C>T	c.(277-279)TCA>TTA	p.S93L	ZSWIM7_uc002gpf.2_Missense_Mutation_p.S93L|ZSWIM7_uc002gpg.2_RNA	NM_001042698	NP_001036163	Q19AV6	ZSWM7_HUMAN	zinc finger, SWIM-type containing 7	93	SWIM-type.				DNA recombination|DNA repair	nucleus	zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0827)		CCGTAGCACTGAGAATGCAAA	0.428													10	12					0	0	0.000978159	0	0
MYO15A	51168	broad.mit.edu	37	17	18022910	18022911	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:18022910_18022911CC>TT	uc010vxh.1	+	2	1134_1135	c.796_797CC>TT	c.(796-798)CCC>TTC	p.P266F		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	266	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GGGCCTCGGCCCCTACAGCCCG	0.644													10	22					0	0	6.4e-05	0	0
CCDC144C	348254	broad.mit.edu	37	17	20224893	20224893	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:20224893C>T	uc010cqy.1	+	1		c.407C>T				NR_023380				Homo sapiens cDNA FLJ59693 complete cds, moderately similar to Ankyrin repeat domain-containing protein 26.												0						ACAGAGCTGCCCGGTCGGGCG	0.622													56	123					0	0	0.000781405	0	0
LGALS9B	284194	broad.mit.edu	37	17	20363713	20363713	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:20363713C>T	uc002gxa.1	-	2	148	c.83G>A	c.(82-84)GGA>GAA	p.G28E	LGALS9B_uc002gwz.1_Missense_Mutation_p.G28E|LGALS9B_uc010vzh.1_Intron	NM_001042685	NP_001036150	Q3B8N2	LEG9B_HUMAN	galectin-9 like	28	Galectin 1.						sugar binding			skin(1)	1						GATCTGAAATCCGTCCTGGAG	0.567													29	69					0	0	0.00128727	0	0
FOXN1	8456	broad.mit.edu	37	17	26861982	26861983	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:26861982_26861983CC>TT	uc010crm.2	+	8	1591_1592	c.1393_1394CC>TT	c.(1393-1395)CCT>TTT	p.P465F	FOXN1_uc002hbj.2_Missense_Mutation_p.P465F	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	465					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CCTGGCCCCTCCTGGACCCCCG	0.668													5	13					0	0	6.4e-05	0	0
SUPT6H	6830	broad.mit.edu	37	17	27011697	27011697	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:27011697C>T	uc002hby.2	+	18	2413	c.2323C>T	c.(2323-2325)CAA>TAA	p.Q775*	SUPT6H_uc010crt.2_Nonsense_Mutation_p.Q775*	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	775					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					GGACGAGAACCAAGGGAAGGG	0.507													25	43					0	0	0.000720815	0	0
ATAD5	79915	broad.mit.edu	37	17	29220499	29220499	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:29220499G>A	uc002hfs.1	+	21	4974	c.4628G>A	c.(4627-4629)AGT>AAT	p.S1543N		NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	1543					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				GCAACAAAAAGTATGAATTGT	0.353													36	56					0	0	0.00058488	0	0
NF1	4763	broad.mit.edu	37	17	29665142	29665142	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:29665142C>T	uc002hgg.2	+	45	7137	c.6804C>T	c.(6802-6804)ATC>ATT	p.I2268I	NF1_uc002hgh.2_Silent_p.I2247I|NF1_uc010cso.2_Silent_p.I456I|NF1_uc010wbt.1_Intron|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2268					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AGCAGATAATCCGTATTCTTA	0.388			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			47	79					0	0	0.000781405	0	0
MYO1D	4642	broad.mit.edu	37	17	31039087	31039087	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:31039087G>A	uc002hho.1	-	16	2052	c.2040C>T	c.(2038-2040)TTC>TTT	p.F680F	MYO1D_uc002hhp.1_Silent_p.F680F	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	680	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			GTGTTCGAATGAAAATTTTGG	0.403													78	85					0	0	0.000781405	0	0
HNF1B	6928	broad.mit.edu	37	17	36099441	36099441	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:36099441C>T	uc002hok.3	-	2	755	c.534G>A	c.(532-534)GAG>GAA	p.E178E	HNF1B_uc010wdi.1_Silent_p.E178E	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	178					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GTCGGAGGATCTCTCGTTGCT	0.542									Hereditary_Prostate_Cancer				125	170					0	0	0.000781405	0	0
KRT15	3866	broad.mit.edu	37	17	39672221	39672221	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:39672221C>T	uc002hwy.2	-	5	1133	c.942G>A	c.(940-942)ATG>ATA	p.M314I	KRT15_uc002hwz.2_Missense_Mutation_p.M216I|KRT15_uc002hxa.2_Missense_Mutation_p.M149I|KRT15_uc002hxb.1_Missense_Mutation_p.M149I	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	314	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TGGTCTGGATCATTTCTGTGT	0.592													46	110					0	0	0.000781405	0	0
EZH1	2145	broad.mit.edu	37	17	40865335	40865335	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:40865335G>A	uc002iaz.2	-	11	1241	c.1096C>T	c.(1096-1098)CAC>TAC	p.H366Y	EZH1_uc002iba.2_Missense_Mutation_p.H357Y|EZH1_uc010wgt.1_Missense_Mutation_p.H296Y|EZH1_uc010wgu.1_Missense_Mutation_p.H372Y|EZH1_uc010wgv.1_Missense_Mutation_p.H326Y|EZH1_uc010wgw.1_Missense_Mutation_p.H227Y|EZH1_uc010cyp.2_Missense_Mutation_p.H267Y|EZH1_uc010cyq.2_Missense_Mutation_p.H283Y|EZH1_uc010cys.2_Missense_Mutation_p.H317Y|EZH1_uc010cyo.1_Missense_Mutation_p.H29Y|EZH1_uc010cyr.1_Missense_Mutation_p.H18Y	NM_001991	NP_001982	Q92800	EZH1_HUMAN	enhancer of zeste homolog 1	366					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			ovary(3)	3		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		CTGACTATGTGGTGCCTTCTC	0.562													28	53					0	0	0.000878237	0	0
DUSP3	1845	broad.mit.edu	37	17	41847063	41847063	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:41847063G>A	uc002ied.3	-	3	548	c.472C>T	c.(472-474)CGT>TGT	p.R158C	DUSP3_uc002iee.3_3'UTR|DUSP3_uc002ief.1_Missense_Mutation_p.R115C	NM_004090	NP_004081	P51452	DUS3_HUMAN	dual specificity phosphatase 3	158	Tyrosine-protein phosphatase.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of JNK cascade|negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|immunological synapse|nucleoplasm	MAP kinase phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		Breast(137;0.00725)		BRCA - Breast invasive adenocarcinoma(366;0.116)		CCGATCTCACGGTTCTGCCTC	0.592													11	33					0	0	0.00136819	0	0
EFTUD2	9343	broad.mit.edu	37	17	42934475	42934475	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:42934475G>A	uc002ihn.2	-	20	2274	c.2013C>T	c.(2011-2013)TCC>TCT	p.S671S	EFTUD2_uc010wje.1_Silent_p.S636S|EFTUD2_uc010wjf.1_Silent_p.S661S	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	671						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				AGCACTTGAGGGAGGATGTTT	0.488													36	44					0	0	0.00222228	0	0
EFTUD2	9343	broad.mit.edu	37	17	42936451	42936451	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:42936451G>A	uc002ihn.2	-	19	2220	c.1959C>T	c.(1957-1959)ATC>ATT	p.I653I	EFTUD2_uc010wje.1_Silent_p.I618I|EFTUD2_uc010wjf.1_Silent_p.I643I	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	653						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				GCTGTACCTTGATGTCTATCT	0.522													22	40					0	0	0.000375601	0	0
KPNB1	3837	broad.mit.edu	37	17	45750523	45750523	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:45750523C>T	uc002ilt.1	+	13	2023	c.1687C>T	c.(1687-1689)CAG>TAG	p.Q563*	KPNB1_uc010wkw.1_Nonsense_Mutation_p.Q418*|KPNB1_uc010wkx.1_Nonsense_Mutation_p.Q347*	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	563					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						ACAGGTTCTTCAGATGGAGGT	0.443													38	55					0	0	0.00148497	0	0
OSBPL7	114881	broad.mit.edu	37	17	45885931	45885931	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:45885931T>C	uc002ilx.1	-	22	2596	c.2393A>G	c.(2392-2394)AAC>AGC	p.N798S	OSBPL7_uc002ilw.1_Missense_Mutation_p.N360S	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	798					lipid transport		lipid binding				0						GTGTACGATGTTGTTTTCCTC	0.627													73	104					0	0	0.000781405	0	0
HOXB1	3211	broad.mit.edu	37	17	46607022	46607022	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:46607022C>T	uc002ink.1	-	2	799	c.793G>A	c.(793-795)GAA>AAA	p.E265K		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	265						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACCCGACCTTCCTCTCGCTCG	0.622													36	62					0	0	0.00128727	0	0
HOXB8	3218	broad.mit.edu	37	17	46691682	46691682	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:46691682G>A	uc002inw.2	-	1	620	c.385C>T	c.(385-387)CCG>TCG	p.P129S		NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	129						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GTGGGCGACGGGCTCTGCTCG	0.711													4	10					0	0	0.00024832	0	0
CACNA1G	8913	broad.mit.edu	37	17	48696108	48696108	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:48696108C>T	uc002irk.1	+	33	5892	c.5520C>T	c.(5518-5520)TTC>TTT	p.F1840F	CACNA1G_uc002irj.1_Silent_p.F1806F|CACNA1G_uc002irl.1_Silent_p.F1817F|CACNA1G_uc002irm.1_Silent_p.F1806F|CACNA1G_uc002irn.1_Silent_p.F1799F|CACNA1G_uc002iro.1_Silent_p.F1806F|CACNA1G_uc002irp.1_Silent_p.F1840F|CACNA1G_uc002irq.1_Silent_p.F1817F|CACNA1G_uc002irr.1_Silent_p.F1840F|CACNA1G_uc002irs.1_Silent_p.F1829F|CACNA1G_uc002irt.1_Silent_p.F1822F|CACNA1G_uc002irv.1_Silent_p.F1829F|CACNA1G_uc002irw.1_Silent_p.F1817F|CACNA1G_uc002iru.1_Silent_p.F1806F|CACNA1G_uc002irx.1_Silent_p.F1753F|CACNA1G_uc002iry.1_Silent_p.F1742F|CACNA1G_uc002irz.1_Silent_p.F1746F|CACNA1G_uc002isa.1_Silent_p.F1719F|CACNA1G_uc002isb.1_Silent_p.F1760F|CACNA1G_uc002isc.1_Silent_p.F1742F|CACNA1G_uc002isd.1_Silent_p.F1728F|CACNA1G_uc002ise.1_Silent_p.F1708F|CACNA1G_uc002isf.1_Silent_p.F1735F|CACNA1G_uc002isg.1_Silent_p.F1701F|CACNA1G_uc002ish.1_Silent_p.F1708F|CACNA1G_uc002isi.1_Silent_p.F1696F	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1840	IV.|Helical; Name=S6 of repeat IV; (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CGGCCCAGTTCGTGCTAGTCA	0.602													16	30					0	0	0.000566183	0	0
CACNA1G	8913	broad.mit.edu	37	17	48701370	48701370	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:48701370C>T	uc002irk.1	+	36	6535	c.6163C>T	c.(6163-6165)CGG>TGG	p.R2055W	CACNA1G_uc002irj.1_Missense_Mutation_p.R1928W|CACNA1G_uc002irl.1_Missense_Mutation_p.R1939W|CACNA1G_uc002irm.1_Missense_Mutation_p.R1976W|CACNA1G_uc002irn.1_Missense_Mutation_p.R1921W|CACNA1G_uc002iro.1_Missense_Mutation_p.R1928W|CACNA1G_uc002irp.1_Missense_Mutation_p.R2010W|CACNA1G_uc002irq.1_Missense_Mutation_p.R2032W|CACNA1G_uc002irr.1_Missense_Mutation_p.R1962W|CACNA1G_uc002irs.1_Missense_Mutation_p.R1999W|CACNA1G_uc002irt.1_Missense_Mutation_p.R1944W|CACNA1G_uc002irv.1_Missense_Mutation_p.R1951W|CACNA1G_uc002irw.1_Missense_Mutation_p.R1984W|CACNA1G_uc002iru.1_Missense_Mutation_p.R2021W|CACNA1G_uc002irx.1_Missense_Mutation_p.R1875W|CACNA1G_uc002iry.1_Missense_Mutation_p.R1864W|CACNA1G_uc002irz.1_Missense_Mutation_p.R1868W|CACNA1G_uc002isa.1_Missense_Mutation_p.R1841W|CACNA1G_uc002isb.1_Missense_Mutation_p.R1882W|CACNA1G_uc002isc.1_Missense_Mutation_p.R1957W|CACNA1G_uc002isd.1_Missense_Mutation_p.R1850W|CACNA1G_uc002ise.1_Missense_Mutation_p.R1878W|CACNA1G_uc002isf.1_Missense_Mutation_p.R1905W|CACNA1G_uc002isg.1_Missense_Mutation_p.R1823W|CACNA1G_uc002ish.1_Missense_Mutation_p.R1830W|CACNA1G_uc002isi.1_Missense_Mutation_p.R1818W	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	2055	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CTACATGTGTCGGCATGGGAG	0.637													20	30					0	0	0.00121646	0	0
KIF2B	84643	broad.mit.edu	37	17	51900733	51900733	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:51900733G>A	uc002iua.2	+	1	495	c.339G>A	c.(337-339)ACG>ACA	p.T113T	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	113					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						GTACCGCCACGAAATGGGTTG	0.592													30	54					0	0	0.00106085	0	0
TMEM100	55273	broad.mit.edu	37	17	53798413	53798413	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:53798413T>C	uc002iuj.3	-	2	330	c.19A>G	c.(19-21)AAG>GAG	p.K7E	TMEM100_uc002iuk.3_Missense_Mutation_p.K7E	NM_018286	NP_060756	Q9NV29	TM100_HUMAN	transmembrane protein 100	7						integral to membrane					0						AGGATCTCCTTGATGGGCTCT	0.502													38	58					0	0	0.00170553	0	0
ANKFN1	162282	broad.mit.edu	37	17	54428267	54428267	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:54428267C>T	uc002iun.1	+	4	373	c.338C>T	c.(337-339)TCC>TTC	p.S113F		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	113										large_intestine(1)|ovary(1)	2						AGCCACTCTTCCTTCGATGAG	0.453													30	42					0	0	0.001512	0	0
TEX14	56155	broad.mit.edu	37	17	56664997	56664997	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:56664997G>A	uc010dcz.1	-	17	2869	c.2751C>T	c.(2749-2751)ATC>ATT	p.I917I	TEX14_uc002iwr.1_Silent_p.I911I|TEX14_uc002iws.1_Silent_p.I911I|TEX14_uc010dda.1_Silent_p.I691I	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	917						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGCATTATAGATTTCAGAAG	0.383											OREG0024616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	35					0	0	0.000375601	0	0
TEX14	56155	broad.mit.edu	37	17	56692624	56692624	+	Missense_Mutation	SNP	C	T	T	rs140185813	by1000genomes	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:56692624C>T	uc010dcz.1	-	8	986	c.868G>A	c.(868-870)GAC>AAC	p.D290N	TEX14_uc002iwr.1_Missense_Mutation_p.D284N|TEX14_uc002iws.1_Missense_Mutation_p.D284N|TEX14_uc010dda.1_Missense_Mutation_p.D64N	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	290	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATTAACAAGTCGGCCAGCCGC	0.557													40	54					0	0	0.000781405	0	0
APPBP2	10513	broad.mit.edu	37	17	58524995	58524995	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:58524995C>A	uc002iys.1	-	13	1993	c.1705G>T	c.(1705-1707)GAA>TAA	p.E569*	APPBP2_uc010ddl.1_Nonsense_Mutation_p.E498*	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	569					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			TGCACCACTTCTTCAGTGGAC	0.498													57	95					2.01871e-26	8.44822e-26	0.000781405	1	0
MAP3K3	4215	broad.mit.edu	37	17	61768530	61768530	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:61768530C>T	uc002jbg.2	+	13	1600	c.1281C>T	c.(1279-1281)TAC>TAT	p.Y427Y	MAP3K3_uc002jbe.2_Silent_p.Y458Y|MAP3K3_uc002jbf.2_Silent_p.Y458Y|MAP3K3_uc002jbh.2_Silent_p.Y454Y|MAP3K3_uc010wpo.1_Silent_p.Y342Y|MAP3K3_uc010wpp.1_Silent_p.Y423Y	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	427	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						TCGTGCAGTACTATGGCTGTC	0.562													17	31					0	0	0.000958276	0	0
ERN1	2081	broad.mit.edu	37	17	62137861	62137861	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:62137861G>A	uc002jdz.2	-	11	1287	c.1174C>T	c.(1174-1176)CCT>TCT	p.P392S		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	392	Lumenal (Potential).				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						GAATCAGCAGGAATCACATTT	0.398													31	59					0	0	0.000814825	0	0
CACNG4	27092	broad.mit.edu	37	17	65026931	65026931	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:65026931C>T	uc002jft.1	+	4	810	c.795C>T	c.(793-795)ATC>ATT	p.I265I		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	265	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GCCTGAAGATCACAGGGGCCA	0.677													16	21					0	0	0.000308642	0	0
FAM20A	54757	broad.mit.edu	37	17	66533797	66533797	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:66533797C>T	uc002jho.2	-	11	1735	c.1447G>A	c.(1447-1449)GAA>AAA	p.E483K	FAM20A_uc010wqp.1_Missense_Mutation_p.E345K|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Missense_Mutation_p.E194K	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	483						extracellular region					0	Breast(10;1.64e-13)					AGCTGGTCTTCCAGCAGTGAT	0.527													9	10					0	0	0.000274275	0	0
DNAI2	64446	broad.mit.edu	37	17	72305515	72305515	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:72305515C>T	uc002jkf.2	+	10	1434	c.1335C>T	c.(1333-1335)ACC>ACT	p.T445T	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA|uc002jkh.1_Missense_Mutation_p.G74S|DNAI2_uc002jki.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	445	WD 5.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						GCGATCCCACCCTCAGCTTGA	0.612									Kartagener_syndrome				11	24					0	0	0.000219431	0	0
TMEM104	54868	broad.mit.edu	37	17	72832536	72832537	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:72832536_72832537CC>TT	uc002jls.3	+	10	1363_1364	c.1201_1202CC>TT	c.(1201-1203)CCC>TTC	p.P401F	TMEM104_uc010wrf.1_Intron|TMEM104_uc010wrg.1_Intron|TMEM104_uc010dfx.2_Missense_Mutation_p.P401F	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	401	Helical; (Potential).					integral to membrane					0	all_lung(278;0.23)					CGTCGTGTTTCCCACCATCACC	0.658													17	26					0	0	6.4e-05	0	0
FOXJ1	2302	broad.mit.edu	37	17	74136356	74136356	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:74136356C>T	uc002jqw.2	-	1	211	c.121G>A	c.(121-123)GAA>AAA	p.E41K	FOXJ1_uc002jqx.2_Missense_Mutation_p.E41K|uc002jqy.1_5'Flank	NM_001454	NP_001445	Q92949	FOXJ1_HUMAN	forkhead box J1	41					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			pancreas(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			ATGGAGAATTCCTGCAGCCAC	0.751													8	14					0	0	0.000442599	0	0
MGAT5B	146664	broad.mit.edu	37	17	74942495	74942495	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:74942495G>A	uc002jti.2	+	14	2016	c.1913G>A	c.(1912-1914)GGG>GAG	p.G638E	MGAT5B_uc002jth.2_Missense_Mutation_p.G627E|MGAT5B_uc002jtj.2_Missense_Mutation_p.G34E	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	629	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						ACCTGCGAGGGGATGCTGGAG	0.662													7	21					0	0	0.000442599	0	0
DNAH17	8632	broad.mit.edu	37	17	76449483	76449483	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:76449483C>T	uc010dhp.1	-	10	1693	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCACGGTTTCGCCGATGTTC	0.562													7	14					0	0	0.00198382	0	0
Unknown	0	broad.mit.edu	37	17	78268774	78268774	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:78268774G>T	uc002jyf.2	+	9	1870	c.1727G>T	c.(1726-1728)TGG>TTG	p.W576L	uc002jyg.1_Missense_Mutation_p.W307L	NM_020954	NP_066005			hypothetical protein LOC57714																		GCACAGCTGTGGACCGATTTG	0.542													15	45					3.52763e-06	1.46596e-05	0.000566183	1	0
ARHGDIA	396	broad.mit.edu	37	17	79827439	79827439	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:79827439G>A	uc002kbp.2	-	2	292	c.253C>T	c.(253-255)CCC>TCC	p.P85S	ARHGDIA_uc002kjk.1_5'UTR|ARHGDIA_uc002kbq.2_Missense_Mutation_p.P85S|ARHGDIA_uc002kbr.2_Missense_Mutation_p.P85S|ARHGDIA_uc002kbs.1_Intron|ARHGDIA_uc002kbt.1_Missense_Mutation_p.P85S|ARHGDIA_uc010dig.1_RNA	NM_004309	NP_004300	P52565	GDIR1_HUMAN	Rho GDP dissociation inhibitor (GDI) alpha	85					anti-apoptosis|cellular component movement|negative regulation of axonogenesis|negative regulation of cell adhesion|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytoskeleton|cytosol	GTPase activator activity|identical protein binding|Rho GDP-dissociation inhibitor activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			AGCTCCAGGGGGCCCGGGGCC	0.746													4	7					0	0	0.00024832	0	0
HEXDC	284004	broad.mit.edu	37	17	80382276	80382276	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:80382276C>T	uc002kew.2	+	2	142	c.91C>T	c.(91-93)CCT>TCT	p.P31S	HEXDC_uc002kev.3_Missense_Mutation_p.P31S|HEXDC_uc010diq.2_Missense_Mutation_p.P31S			Q8WVB3	HEXDC_HUMAN	SubName: Full=Hexosaminidase (Glycosyl hydrolase family 20, catalytic domain) containing, isoform CRA_c; SubName: Full=Hexosaminidase D;	31					carbohydrate metabolic process	cytoplasm|nucleus	beta-N-acetylhexosaminidase activity|cation binding			ovary(1)|skin(1)	2	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CCAGATTTTTCCTCTGTTCCG	0.567													25	41					0	0	0.00127121	0	0
ZNF750	79755	broad.mit.edu	37	17	80790255	80790255	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:80790255T>C	uc002kga.2	-	2	387	c.76A>G	c.(76-78)AAA>GAA	p.K26E	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	26						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGGAAACATTTATACTTGAAG	0.408													31	65					0	0	0.00058488	0	0
B3GNTL1	146712	broad.mit.edu	37	17	80963044	80963044	+	Missense_Mutation	SNP	C	T	T	rs151094014	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:80963044C>T	uc002kgg.1	-	6	465	c.451G>A	c.(451-453)GAA>AAA	p.E151K	B3GNTL1_uc002kgf.1_Missense_Mutation_p.E40K|B3GNTL1_uc002kge.1_RNA	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	151							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			GTGTATCGTTCGGTGGAGTTA	0.562													33	74					0	0	0.00170553	0	0
ANKRD12	23253	broad.mit.edu	37	18	9255150	9255150	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:9255150C>T	uc002knv.2	+	9	2142	c.1885C>T	c.(1885-1887)CAT>TAT	p.H629Y	ANKRD12_uc002knw.2_Missense_Mutation_p.H606Y|ANKRD12_uc002knx.2_Missense_Mutation_p.H606Y|ANKRD12_uc010dkx.1_Missense_Mutation_p.H336Y	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	629						nucleus				ovary(2)|central_nervous_system(1)	3						GGATGAAGATCATAGTCCAAC	0.174													33	15					0	0	0.0024448	0	0
CEP76	79959	broad.mit.edu	37	18	12699056	12699056	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:12699056G>A	uc002kri.2	-	4	598	c.442C>T	c.(442-444)CGT>TGT	p.R148C	PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_5'UTR|CEP76_uc010wzz.1_Intron|CEP76_uc010xaa.1_5'UTR|CEP76_uc010xab.1_3'UTR	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	148					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						GGTTTAGAACGAAAACGTTGG	0.373													27	13					0	0	0.00106085	0	0
ZNF519	162655	broad.mit.edu	37	18	14124377	14124377	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:14124377C>T	uc002kst.1	-	2	255	c.102G>A	c.(100-102)TTG>TTA	p.L34L	ZNF519_uc002ksq.1_RNA|ZNF519_uc002ksr.1_Intron|ZNF519_uc010dlm.1_RNA	NM_145287	NP_660330	Q8TB69	ZN519_HUMAN	zinc finger protein 519	34	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTAGTTCTCCAACATCACAT	0.403													5	42					0	0	0.000602214	0	0
LAMA3	3909	broad.mit.edu	37	18	21501454	21501454	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:21501454G>A	uc002kuq.2	+	62	8168	c.8082G>A	c.(8080-8082)TGG>TGA	p.W2694*	LAMA3_uc002kur.2_Nonsense_Mutation_p.W2638*|LAMA3_uc002kus.3_Nonsense_Mutation_p.W1085*|LAMA3_uc002kut.3_Nonsense_Mutation_p.W1029*	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2694	Laminin G-like 2.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCGTATGTGGATAAATGTGG	0.368													25	52					0	0	0.000720815	0	0
CHST9	83539	broad.mit.edu	37	18	24496402	24496402	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:24496402C>T	uc002kwd.2	-	5	1351	c.1153G>A	c.(1153-1155)GGT>AGT	p.G385S	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Missense_Mutation_p.G300S|CHST9_uc002kwe.2_Missense_Mutation_p.G385S	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	385	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					TTTGGAGCACCGATCATCTGT	0.398													43	68					0	0	0.00170553	0	0
DSC1	1823	broad.mit.edu	37	18	28728530	28728530	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:28728530C>T	uc002kwn.2	-	6	965	c.703G>A	c.(703-705)GAT>AAT	p.D235N	DSC1_uc002kwm.2_Missense_Mutation_p.D235N	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	235	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTATCATTATCATCTTCAATT	0.383													38	50					0	0	0.000814825	0	0
DSG3	1830	broad.mit.edu	37	18	29039874	29039874	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:29039874C>T	uc002kws.2	+	6	693	c.584C>T	c.(583-585)GCC>GTC	p.A195V		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	195	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TCTAAAATTGCCTTCAAAATT	0.418													23	39					0	0	0.000586117	0	0
DSG2	1829	broad.mit.edu	37	18	29126475	29126475	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:29126475G>A	uc002kwu.3	+	15	3314	c.3126G>A	c.(3124-3126)CAG>CAA	p.Q1042Q	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	1042	Desmoglein repeat 6.|Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			CAGTAGGACAGAATGTGACAG	0.498													30	44					0	0	0.00127121	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093079	30093079	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:30093079C>T	uc010dmc.2	+	1		c.1454C>T				NR_003558				Homo sapiens cDNA clone IMAGE:5265376, partial cds.												0						GGAGCTCCTCCTGAGACCACC	0.572													3	6					0	0	6.4e-05	0	0
KIAA1328	57536	broad.mit.edu	37	18	34647216	34647216	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:34647216C>T	uc002kzz.2	+	7	962	c.940C>T	c.(940-942)CGT>TGT	p.R314C	KIAA1328_uc002lab.2_Missense_Mutation_p.R30C|KIAA1328_uc002lac.1_Missense_Mutation_p.R137C|KIAA1328_uc010dnc.1_RNA|KIAA1328_uc002lad.2_Missense_Mutation_p.R30C	NM_020776	NP_065827	Q86T90	K1328_HUMAN	hypothetical protein LOC57536	314										central_nervous_system(1)	1				COAD - Colon adenocarcinoma(74;0.195)		TGCTGCAGATCGTGTTCATGA	0.458													21	39					0	0	0.000375601	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560836	44560836	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:44560836G>A	uc002lcr.1	-	1	1153	c.800C>T	c.(799-801)TCC>TTC	p.S267F	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	267					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						ACTTGCCCAGGAGGGCATCCT	0.607													33	59					0	0	0.00058488	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561311	44561311	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:44561311C>T	uc002lcr.1	-	1	678	c.325G>A	c.(325-327)GCC>ACC	p.A109T	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	109					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						AAGCCCCAGGCCTTTTCCTGG	0.662													26	47					0	0	0.001512	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024677	55024677	+	Missense_Mutation	SNP	G	A	A	rs145545626		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:55024677G>A	uc002lgn.2	+	3	1193	c.836G>A	c.(835-837)GGA>GAA	p.G279E		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	279	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	p.G279E(1)		breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		GCTTGGCCGGGAAATATAATG	0.408													44	59					0	0	0.000781405	0	0
CPLX4	339302	broad.mit.edu	37	18	56985680	56985680	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:56985680C>T	uc002lhy.2	-	1	202	c.15G>A	c.(13-15)ATG>ATA	p.M5I		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	5					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				TCATACTTTTCATAAGGAAAG	0.368													15	28					0	0	0.000219431	0	0
CDH20	28316	broad.mit.edu	37	18	59170282	59170282	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:59170282G>A	uc010dps.1	+	4	770	c.758G>A	c.(757-759)GGA>GAA	p.G253E	CDH20_uc002lif.2_Missense_Mutation_p.G247E	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	253	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CAGCTTGGAGGATTAGCTGGG	0.502											OREG0025026	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	64					0	0	0.000720815	0	0
KIAA1468	57614	broad.mit.edu	37	18	59895551	59895551	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:59895551C>T	uc002lil.2	+	8	1383	c.1168C>T	c.(1168-1170)CTC>TTC	p.L390F	KIAA1468_uc002lik.1_Missense_Mutation_p.L390F|KIAA1468_uc010xel.1_Missense_Mutation_p.L390F|KIAA1468_uc002lim.2_Missense_Mutation_p.L34F	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	390	Potential.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				AATGGACTTCCTCAAAAATGA	0.403													32	67					0	0	0.00058488	0	0
SALL3	27164	broad.mit.edu	37	18	76754644	76754644	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr18:76754644G>A	uc002lmt.2	+	2	2653	c.2653G>A	c.(2653-2655)GAC>AAC	p.D885N	SALL3_uc010dra.2_Missense_Mutation_p.D492N	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	885					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGCCGTGGGCGACCTGGAGAG	0.701													16	21					0	0	0.00074312	0	0
PPAP2C	8612	broad.mit.edu	37	19	287583	287583	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:287583G>A	uc002loi.2	-	3	472	c.373C>T	c.(373-375)CCC>TCC	p.P125S	PPAP2C_uc002loh.2_Missense_Mutation_p.P146S|PPAP2C_uc002loj.2_Missense_Mutation_p.P69S	NM_003712	NP_003703	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C isoform 1	125					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)	1		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGAAGTTGGGCCTCAGACGC	0.602													29	54					0	0	0.00178596	0	0
HCN2	610	broad.mit.edu	37	19	614009	614009	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:614009C>T	uc002lpe.2	+	7	2036	c.1983C>T	c.(1981-1983)GAC>GAT	p.D661D		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	661	cAMP.|Cytoplasmic (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCGCCTGGACCGCATCGGTG	0.706													5	14					0	0	0.000602214	0	0
ZNF555	148254	broad.mit.edu	37	19	2853171	2853171	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:2853171T>G	uc002lwo.2	+	4	1197	c.1108T>G	c.(1108-1110)TGC>GGC	p.C370G	ZNF555_uc002lwn.3_Missense_Mutation_p.C369G	NM_152791	NP_690004	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	370	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCCTACGAATGCAAACAGTG	0.448													6	9					0	0	0.00116845	0	0
ATCAY	85300	broad.mit.edu	37	19	3905499	3905499	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:3905499C>T	uc002lyy.3	+	4	634	c.204C>T	c.(202-204)ATC>ATT	p.I68I	ATCAY_uc010xhz.1_Silent_p.I74I	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	68					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		CCCCAGAGATCAACATTTCTC	0.507													10	7					0	0	0.000442599	0	0
SHD	56961	broad.mit.edu	37	19	4288268	4288268	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:4288268G>A	uc002lzw.2	+	5	2208	c.745G>A	c.(745-747)GAT>AAT	p.D249N	SHD_uc010dtu.2_Intron	NM_020209	NP_064594	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming	249	SH2.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		GAACAGGGCGGATGCAGAGAG	0.537													12	23					0	0	0.000219431	0	0
FEM1A	55527	broad.mit.edu	37	19	4792820	4792820	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:4792820C>T	uc002mbf.2	+	1	1093	c.954C>T	c.(952-954)GCC>GCT	p.A318A	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	318	TPR 1.				regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TGCTTGGGGCCCTTAAACACT	0.597													12	20					0	0	0.00136819	0	0
VAV1	7409	broad.mit.edu	37	19	6822340	6822341	+	Splice_Site	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:6822340_6822341GG>AA	uc002mfu.1	+	5	655	c.558_splice	c.e5+1	p.P186_splice	VAV1_uc010xjh.1_Splice_Site_p.P186_splice|VAV1_uc010dva.1_Splice_Site_p.P186_splice|VAV1_uc002mfv.1_Splice_Site_p.P131_splice	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						TGTCCATGCCGGTGCGTGACGT	0.673													4	6					0	0	6.4e-05	0	0
EMR1	2015	broad.mit.edu	37	19	6908704	6908704	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:6908704C>T	uc002mfw.2	+	10	1081	c.1043C>T	c.(1042-1044)TCC>TTC	p.S348F	EMR1_uc010dvc.2_Missense_Mutation_p.S348F|EMR1_uc010dvb.2_Missense_Mutation_p.S296F|EMR1_uc010xji.1_Missense_Mutation_p.S207F|EMR1_uc010xjj.1_Missense_Mutation_p.S171F	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	348	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					ACGCAGGTCTCCTTTTGTGCA	0.383													24	48					0	0	0.000720815	0	0
XAB2	56949	broad.mit.edu	37	19	7692252	7692252	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:7692252G>A	uc002mgx.2	-	4	425	c.399C>T	c.(397-399)TTC>TTT	p.F133F	uc010dvi.1_5'Flank	NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	133	HAT 4.				transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						GGGCACGGTCGAAGGTGCGGC	0.647								Direct_reversal_of_damage|NER					10	9					0	0	0.000673444	0	0
CD209	30835	broad.mit.edu	37	19	7810954	7810954	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:7810954G>A	uc002mht.2	-	4	265	c.198C>T	c.(196-198)TCC>TCT	p.S66S	CD209_uc010xju.1_Silent_p.S66S|CD209_uc010dvp.2_Silent_p.S42S|CD209_uc002mhr.2_Silent_p.S42S|CD209_uc002mhs.2_Silent_p.S42S|CD209_uc002mhu.2_Silent_p.S66S|CD209_uc010dvq.2_Silent_p.S66S|CD209_uc002mhq.2_Silent_p.S66S|CD209_uc002mhv.2_Silent_p.S42S|CD209_uc002mhx.2_Silent_p.S22S|CD209_uc002mhw.2_Silent_p.S22S|CD209_uc010dvr.2_Silent_p.S66S	NM_021155	NP_066978	Q9NNX6	CD209_HUMAN	CD209 molecule isoform 1	66	Extracellular (Probable).				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			skin(1)	1						CCTGACTTATGGAGCTGGGGA	0.378													39	92					0	0	0.000509022	0	0
MUC16	94025	broad.mit.edu	37	19	9027568	9027568	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9027568G>A	uc002mkp.2	-	12	36780	c.36576C>T	c.(36574-36576)ACC>ACT	p.T12192T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12194	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCTTCGATGGGTGAAACCTG	0.537													25	25					0	0	0.000878237	0	0
MUC16	94025	broad.mit.edu	37	19	9045944	9045944	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9045944G>A	uc002mkp.2	-	5	35891	c.35687C>T	c.(35686-35688)TCC>TTC	p.S11896F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11898	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACAGCAGGGGAAACAGTCAG	0.488													34	69					0	0	0.00058488	0	0
MUC16	94025	broad.mit.edu	37	19	9046062	9046062	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9046062C>T	uc002mkp.2	-	5	35773	c.35569G>A	c.(35569-35571)GAA>AAA	p.E11857K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11859	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGCTGGTTTCTGTCCCTGGA	0.493													33	56					0	0	0.00058488	0	0
MUC16	94025	broad.mit.edu	37	19	9046254	9046254	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9046254G>A	uc002mkp.2	-	5	35581	c.35377C>T	c.(35377-35379)CCT>TCT	p.P11793S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11795	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GATACTTGAGGAAACACAGTT	0.478													17	16					0	0	0.000566183	0	0
MUC16	94025	broad.mit.edu	37	19	9048845	9048845	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9048845C>T	uc002mkp.2	-	5	32990	c.32786G>A	c.(32785-32787)GGG>GAG	p.G10929E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10931	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCTGGTACCCCAGGTGAAAC	0.493													26	46					0	0	0.000586117	0	0
MUC16	94025	broad.mit.edu	37	19	9056878	9056878	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9056878G>A	uc002mkp.2	-	3	30772	c.30568C>T	c.(30568-30570)CCT>TCT	p.P10190S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10192	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGACCCAGGAGAAGAAGGT	0.453													32	36					0	0	0.000491102	0	0
MUC16	94025	broad.mit.edu	37	19	9059483	9059483	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9059483G>A	uc002mkp.2	-	3	28167	c.27963C>T	c.(27961-27963)TCC>TCT	p.S9321S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9323	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTTCTGTCCTGGAGACCTCAG	0.498													31	60					0	0	0.000491102	0	0
MUC16	94025	broad.mit.edu	37	19	9063850	9063850	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9063850C>T	uc002mkp.2	-	3	23800	c.23596G>A	c.(23596-23598)GAA>AAA	p.E7866K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7868	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGACGTCTTCCTTGGAGATC	0.537													17	36					0	0	0.000422831	0	0
MUC16	94025	broad.mit.edu	37	19	9072702	9072702	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9072702A>G	uc002mkp.2	-	3	14948	c.14744T>C	c.(14743-14745)GTT>GCT	p.V4915A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4917	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTGTAAGGAACAGTGCTTGT	0.522													34	91					0	0	0.00058488	0	0
MUC16	94025	broad.mit.edu	37	19	9077469	9077469	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9077469C>T	uc002mkp.2	-	3	10181	c.9977G>A	c.(9976-9978)GGG>GAG	p.G3326E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3327	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGACCAGTCCCTGTGATGCT	0.517													35	56					0	0	0.00058488	0	0
MUC16	94025	broad.mit.edu	37	19	9083027	9083027	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9083027A>T	uc002mkp.2	-	1	8992	c.8788T>A	c.(8788-8790)TCC>ACC	p.S2930T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2931	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAGACTTGGACAGTGAGGAA	0.468													24	50					0	0	0.000878237	0	0
MUC16	94025	broad.mit.edu	37	19	9086190	9086190	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9086190C>T	uc002mkp.2	-	1	5829	c.5625G>A	c.(5623-5625)TTG>TTA	p.L1875L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1875	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGCCGTTTTCCAATCTGGAGG	0.493													9	19					0	0	0.000274275	0	0
OR7G3	390883	broad.mit.edu	37	19	9236949	9236949	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9236949C>T	uc010xkl.1	-	1	678	c.678G>A	c.(676-678)ATG>ATA	p.M226I		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGGAATTTTCATGACAGAGG	0.423													54	104					0	0	0.000781405	0	0
ZNF317	57693	broad.mit.edu	37	19	9269503	9269503	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9269503T>G	uc002mku.2	+	6	662	c.387T>G	c.(385-387)GAT>GAG	p.D129E	ZNF317_uc002mkv.2_5'UTR|ZNF317_uc002mkw.2_Missense_Mutation_p.D97E|ZNF317_uc002mkx.2_Missense_Mutation_p.D44E|ZNF317_uc002mky.2_Missense_Mutation_p.D12E	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGTTTCAGATTGGGAGACTC	0.413													16	28					0	0	0.000958276	0	0
ZNF317	57693	broad.mit.edu	37	19	9270855	9270855	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9270855C>T	uc002mku.2	+	7	809	c.534C>T	c.(532-534)GAC>GAT	p.D178D	ZNF317_uc002mkv.2_Silent_p.D37D|ZNF317_uc002mkw.2_Silent_p.D146D|ZNF317_uc002mkx.2_Silent_p.D93D|ZNF317_uc002mky.2_Silent_p.D61D	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGGCATGGACCCTCATCTCA	0.552													13	22					0	0	0.00185496	0	0
OR7D4	125958	broad.mit.edu	37	19	9325046	9325046	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:9325046G>A	uc002mla.1	-	1	468	c.468C>T	c.(466-468)TCC>TCT	p.S156S		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TATGAACCAGGGAGAACCAGA	0.527													14	45					0	0	0.000219431	0	0
MRPL4	51073	broad.mit.edu	37	19	10363306	10363306	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:10363306C>T	uc002mnm.2	+	4	358	c.204C>T	c.(202-204)TCC>TCT	p.S68S	MRPL4_uc002mnn.2_Silent_p.S68S|MRPL4_uc002mno.2_Silent_p.S68S	NM_146387	NP_666499	Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4 isoform a	68					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		GGGTCGAGTCCTTGCGGGGCT	0.677													24	31					0	0	0.000586117	0	0
CACNA1A	773	broad.mit.edu	37	19	13423587	13423587	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:13423587C>T	uc010dze.2	-	12	1803	c.1567G>A	c.(1567-1569)GAA>AAA	p.E523K	CACNA1A_uc010dzc.2_Missense_Mutation_p.E48K|CACNA1A_uc002mwy.3_Missense_Mutation_p.E522K|CACNA1A_uc010xne.1_Missense_Mutation_p.E48K	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	523	Helical; Name=S2 of repeat II; (Potential).|II.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	AAAATGAATTCTGCATAGTCT	0.438													9	38					0	0	0.000274275	0	0
C19orf57	79173	broad.mit.edu	37	19	14006280	14006280	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:14006280C>T	uc002mxl.1	-	3	170	c.111G>A	c.(109-111)TTG>TTA	p.L37L	C19orf57_uc002mxk.1_5'Flank|C19orf57_uc002mxm.1_Silent_p.L37L	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	37					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GTAAACAGCCCAACATGGAAC	0.552													53	93					0	0	0.000781405	0	0
EMR3	84658	broad.mit.edu	37	19	14752279	14752279	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:14752279G>A	uc002mzi.3	-	10	1348	c.1200C>T	c.(1198-1200)TTC>TTT	p.F400F	EMR3_uc010dzp.2_Silent_p.F348F|EMR3_uc010xnv.1_Silent_p.F274F	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	400	Helical; Name=2; (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						GGTGGGCCAGGAAGAGGCAGA	0.577													18	43					0	0	0.00121646	0	0
OR1I1	126370	broad.mit.edu	37	19	15198637	15198637	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:15198637C>G	uc010xoe.1	+	1	761	c.761C>G	c.(760-762)ACC>AGC	p.T254S		NM_001004713	NP_001004713	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3						TCCTATGGGACCATCTTTGCT	0.542													3	15					0	0	6.4e-05	0	0
CYP4F8	11283	broad.mit.edu	37	19	15739586	15739586	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:15739586C>T	uc002nbi.2	+	14	1394	c.1330C>T	c.(1330-1332)CGC>TGC	p.R444C	CYP4F8_uc010xoj.1_Missense_Mutation_p.R256C	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	444					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGACCCCTTCCGCTTCGACCC	0.597													11	27					0	0	0.000673444	0	0
OR10H2	26538	broad.mit.edu	37	19	15839424	15839424	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:15839424A>T	uc002nbm.2	+	1	591	c.571A>T	c.(571-573)AAT>TAT	p.N191Y		NM_013939	NP_039227	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GGCCTGTGGAAATAATGTACC	0.517													30	53					0	0	0.0024448	0	0
OR10H3	26532	broad.mit.edu	37	19	15852274	15852274	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:15852274C>T	uc010xoq.1	+	1	72	c.72C>T	c.(70-72)CTC>CTT	p.L24L		NM_013938	NP_039226	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H,	24	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCAGCAGCTCCTGCCTGTCT	0.483													51	114					0	0	0.000781405	0	0
AP1M1	8907	broad.mit.edu	37	19	16338374	16338374	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:16338374C>T	uc002ndu.2	+	7	862	c.689C>T	c.(688-690)TCC>TTC	p.S230F	AP1M1_uc002ndv.2_Missense_Mutation_p.S242F|AP1M1_uc010xpd.1_Missense_Mutation_p.S230F	NM_032493	NP_115882	Q9BXS5	AP1M1_HUMAN	adaptor-related protein complex 1, mu 1 subunit	230	MHD.				cellular membrane organization|endosome to melanosome transport|interspecies interaction between organisms|intracellular protein transport|melanosome organization|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(3)|breast(1)	4						AAAAGCAAATCCGTGGAGCTG	0.602													26	47					0	0	0.001512	0	0
NR2F6	2063	broad.mit.edu	37	19	17351572	17351572	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:17351572G>A	uc002nfq.2	-	2	403	c.281C>T	c.(280-282)TCC>TTC	p.S94F		NM_005234	NP_005225	P10588	NR2F6_HUMAN	nuclear receptor subfamily 2, group F, member 6	94	Nuclear receptor.|NR C4-type.				negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding				0						GTCACGGTTGGACCTGGGGGC	0.612													15	46					0	0	0.00074312	0	0
MAST3	23031	broad.mit.edu	37	19	18233516	18233517	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:18233516_18233517CC>TA	uc002nhz.3	+	5	267_268	c.267_268CC>TA	c.(265-270)CTCCCA>CTTACA	p.P90T		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	90							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						TCGCGTCTCTCCCATCTTCCGG	0.609													4	7					0	0	6.4e-05	0	0
SF4	57794	broad.mit.edu	37	19	19427238	19427238	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:19427238G>A	uc002nmh.2	-	2	201	c.199C>T	c.(199-201)CCT>TCT	p.P67S	SF4_uc002nmi.2_5'UTR|SF4_uc002nmj.2_5'UTR|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	67					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						TACTCGCCAGGATGTGGGGGC	0.567													14	23					0	0	0.000422831	0	0
GMIP	51291	broad.mit.edu	37	19	19744700	19744700	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:19744700G>A	uc002nnd.2	-	19	2501	c.2384C>T	c.(2383-2385)TCC>TTC	p.S795F	GMIP_uc010xrb.1_Missense_Mutation_p.S769F|GMIP_uc010xrc.1_Missense_Mutation_p.S766F	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	795	Pro-rich.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						tgggggctgggagtctgggtc	0.219													5	9					0	0	0.000602214	0	0
ZNF90	7643	broad.mit.edu	37	19	20229372	20229372	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:20229372G>A	uc002nor.2	+	4	1148	c.1009G>A	c.(1009-1011)GGA>AGA	p.G337R	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	337						Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AATCCATACTGGAGAGAAACC	0.413													4	10					0	0	0.00024832	0	0
ZNF708	7562	broad.mit.edu	37	19	21476864	21476864	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:21476864G>A	uc002npq.1	-	4	1102	c.904C>T	c.(904-906)CAT>TAT	p.H302Y	ZNF708_uc002npr.1_Missense_Mutation_p.H238Y|ZNF708_uc010ecs.1_Missense_Mutation_p.H238Y	NM_021269	NP_067092	P17019	ZN708_HUMAN	zinc finger protein 708	302	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(4)|skin(2)	6						TCTCCAGTATGAATTTTCTTG	0.378													12	20					0	0	0.000978159	0	0
ZNF429	353088	broad.mit.edu	37	19	21720483	21720483	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:21720483G>C	uc002nqd.1	+	4	1765	c.1628G>C	c.(1627-1629)GGC>GCC	p.G543A	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	543	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GAAGAATGTGGCAAAGCTTTT	0.363													3	25					0	0	6.4e-05	0	0
ZNF429	353088	broad.mit.edu	37	19	21720495	21720495	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:21720495A>C	uc002nqd.1	+	4	1777	c.1640A>C	c.(1639-1641)AAC>ACC	p.N547T	ZNF429_uc010ecu.1_Intron	NM_001001415	NP_001001415	Q86V71	ZN429_HUMAN	zinc finger protein 429	547	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AAAGCTTTTAACCGGTCCTCA	0.373													3	27					0	0	6.4e-05	0	0
ZNF676	163223	broad.mit.edu	37	19	22364141	22364141	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:22364141T>C	uc002nqs.1	-	3	696	c.378A>G	c.(376-378)TCA>TCG	p.S126S		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TGTTTGAATTTGAACATTTAT	0.328													54	74					0	0	0.000781405	0	0
ZNF99	7652	broad.mit.edu	37	19	22939118	22939118	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:22939118T>A	uc010xrh.1	-	8	3000	c.3000A>T	c.(2998-3000)AAA>AAT	p.K1000N		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATGAATTGTTTTATGTTGAG	0.368													15	5					0	0	0.000422831	0	0
ZNF99	7652	broad.mit.edu	37	19	22940851	22940851	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:22940851G>A	uc010xrh.1	-	5	1587	c.1587C>T	c.(1585-1587)CCC>CCT	p.P529P		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CACATTTGTAGGGTTTCTTTC	0.383													8	17					0	0	0.000673444	0	0
ZNF99	7652	broad.mit.edu	37	19	22941413	22941413	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:22941413G>A	uc010xrh.1	-	5	1025	c.1025C>T	c.(1024-1026)GCT>GTT	p.A342V		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACGCTTAAAAGCTTTGCCACA	0.363													18	32					0	0	0.00188189	0	0
ZNF254	9534	broad.mit.edu	37	19	24310482	24310482	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:24310482C>T	uc002nru.2	+	4	1814	c.1680C>T	c.(1678-1680)ATC>ATT	p.I560I	ZNF254_uc010xrk.1_Silent_p.I475I	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	560	C2H2-type 13.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AGTCTTCAATCCTTACTAACC	0.343													10	20					0	0	0.000673444	0	0
KIAA0355	9710	broad.mit.edu	37	19	34843722	34843722	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:34843722C>T	uc002nvd.3	+	14	3934	c.3075C>T	c.(3073-3075)GAC>GAT	p.D1025D		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	1025										ovary(1)	1	Esophageal squamous(110;0.162)					CAACCAACGACTGCAGTGCCG	0.652													4	5					0	0	0.00024832	0	0
FFAR3	2865	broad.mit.edu	37	19	35850524	35850524	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:35850524C>T	uc002nzd.2	+	2	807	c.732C>T	c.(730-732)TCC>TCT	p.S244S	FFAR3_uc010xsu.1_Intron	NM_005304	NP_005295	O14843	FFAR3_HUMAN	free fatty acid receptor 3	244	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity|lipid binding				0	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			ACAACGTGTCCCATGTCGTGG	0.622													32	87					0	0	0.000953801	0	0
DMKN	93099	broad.mit.edu	37	19	36004094	36004094	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:36004094A>G	uc002nzm.3	-	1	467	c.284T>C	c.(283-285)TTG>TCG	p.L95S	DMKN_uc002nzj.2_5'Flank|DMKN_uc002nzk.3_5'Flank|DMKN_uc002nzl.3_5'Flank|DMKN_uc002nzo.3_Missense_Mutation_p.L95S|DMKN_uc002nzn.3_Missense_Mutation_p.L95S|DMKN_uc002nzw.2_5'Flank|DMKN_uc002nzr.2_5'Flank|DMKN_uc002nzp.2_5'Flank|DMKN_uc002nzq.2_5'Flank|DMKN_uc002nzt.2_5'Flank|DMKN_uc002nzs.2_5'Flank|DMKN_uc002nzu.2_5'Flank|DMKN_uc002nzv.2_5'Flank|DMKN_uc010xsv.1_5'Flank|DMKN_uc010xsw.1_5'Flank|DMKN_uc002nzx.3_5'Flank|DMKN_uc002nzy.3_5'Flank|DMKN_uc002nzz.2_5'Flank|DMKN_uc002oac.3_Missense_Mutation_p.L95S|DMKN_uc010eeb.2_Missense_Mutation_p.L95S|DMKN_uc002oaa.3_Missense_Mutation_p.L95S|DMKN_uc002oab.3_Missense_Mutation_p.L95S	NM_033317	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine isoform 2 precursor	95	Gly-rich.					extracellular region				large_intestine(1)|ovary(1)|skin(1)	3	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCTGTTGCCCAAAGCATCTGC	0.582													11	34					0	0	0.000673444	0	0
RBM42	79171	broad.mit.edu	37	19	36123881	36123881	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:36123881C>T	uc002oan.2	+	5	562	c.486C>T	c.(484-486)GTC>GTT	p.V162V	RBM42_uc010eef.2_Intron|RBM42_uc002oao.2_Intron|RBM42_uc002oap.2_Intron|RBM42_uc002oaq.2_Intron|RBM42_uc010eeg.2_Intron	NM_024321	NP_077297	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	162						cytoplasm|nucleus	nucleotide binding|RNA binding				0	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAGCCTTCGTCCCCCACGTGC	0.632													22	30					0	0	0.000586117	0	0
ZNF565	147929	broad.mit.edu	37	19	36673547	36673547	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:36673547G>A	uc002odn.2	-	5	1429	c.1321C>T	c.(1321-1323)CAC>TAC	p.H441Y	ZNF565_uc010ees.2_Missense_Mutation_p.H376Y|ZNF565_uc002odo.2_Missense_Mutation_p.H441Y	NM_152477	NP_689690	Q8N9K5	ZN565_HUMAN	zinc finger protein 565	441	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.206)			TCACAAGTGTGAATTCGCTGA	0.418													15	20					0	0	0.000566183	0	0
ZNF146	7705	broad.mit.edu	37	19	36728168	36728168	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:36728168G>A	uc002odq.3	+	4	2349	c.826G>A	c.(826-828)GCT>ACT	p.A276T	ZNF146_uc010eet.2_Missense_Mutation_p.A276T|ZNF146_uc010eeu.2_Missense_Mutation_p.A276T	NM_007145	NP_009076	Q15072	OZF_HUMAN	zinc finger protein 146	276	C2H2-type 10.|Interaction with TERF2IP.				regulation of transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|heparin binding|zinc ion binding				0	Esophageal squamous(110;0.162)					ATGTGGGAAAGCTTTCAGCCA	0.403													15	33					0	0	0.000219431	0	0
ZNF793	390927	broad.mit.edu	37	19	38027988	38027988	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:38027988G>A	uc010efm.2	+	8	870	c.428G>A	c.(427-429)GGA>GAA	p.G143E	ZNF793_uc010xts.1_Missense_Mutation_p.G143E|ZNF793_uc010efo.2_Intron	NM_001013659	NP_001013681	Q6ZN11	ZN793_HUMAN	zinc finger protein 793	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AACCCTTGTGGAAAGAATTTG	0.353													8	24					0	0	0.000274275	0	0
ZNF573	126231	broad.mit.edu	37	19	38229711	38229711	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:38229711C>T	uc002ohe.2	-	4	1702	c.1680G>A	c.(1678-1680)GGG>GGA	p.G560G	ZNF573_uc010efs.2_Silent_p.G473G|ZNF573_uc002ohd.2_Silent_p.G558G|ZNF573_uc002ohf.2_Silent_p.G502G|ZNF573_uc002ohg.2_Silent_p.G472G	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	540	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TAAAGGTCTTCCCACATTCCT	0.338													30	32					0	0	0.0024448	0	0
C19orf33	64073	broad.mit.edu	37	19	38795267	38795267	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:38795267G>A	uc002ohu.1	+	3	240	c.142G>A	c.(142-144)GGA>AGA	p.G48R	YIF1B_uc002ohw.2_3'UTR|YIF1B_uc002ohx.2_3'UTR|YIF1B_uc010xtx.1_3'UTR|YIF1B_uc010xty.1_3'UTR|YIF1B_uc002oia.2_3'UTR|YIF1B_uc002ohy.2_3'UTR|YIF1B_uc002ohz.2_3'UTR|C19orf33_uc002ohv.1_Silent_p.K67K	NM_033520	NP_277055	Q9GZP8	IMUP_HUMAN	HAI-2 related small protein	48						nucleus					0	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CATCCAGCAAGGACACCACAG	0.657													16	19					0	0	0.00074312	0	0
RYR1	6261	broad.mit.edu	37	19	38966067	38966067	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:38966067G>A	uc002oit.2	+	29	4400	c.4270G>A	c.(4270-4272)GAG>AAG	p.E1424K	RYR1_uc002oiu.2_Missense_Mutation_p.E1424K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1424	Cytoplasmic.|B30.2/SPRY 3.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGATGACCCCGAGATCATCCT	0.597													8	18					0	0	0.000157383	0	0
CAPN12	147968	broad.mit.edu	37	19	39232476	39232476	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:39232476G>A	uc002ojd.1	-	4	810	c.501C>T	c.(499-501)TTC>TTT	p.F167F		NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	167	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CCGAGCGCACGAACATCAGCT	0.632													10	19					0	0	0.000673444	0	0
RINL	126432	broad.mit.edu	37	19	39362287	39362287	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:39362287C>T	uc002ojq.2	-	6	497	c.109G>A	c.(109-111)GAT>AAT	p.D37N	RINL_uc002ojr.1_5'Flank|RINL_uc010xuo.1_Missense_Mutation_p.D151N	NM_198445	NP_940847	Q6ZS11	RINL_HUMAN	Ras and Rab interactor-like	37							GTPase activator activity			pancreas(1)	1						CGTGCCTCACCTGTGTGTTCA	0.562													15	57					0	0	0.000422831	0	0
RPS16	6217	broad.mit.edu	37	19	39924197	39924197	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:39924197G>A	uc002olk.2	-	4	343	c.260C>T	c.(259-261)TCC>TTC	p.S87F	RPS16_uc002oll.2_Missense_Mutation_p.S70F|RPS16_uc002olm.2_Missense_Mutation_p.P119S	NM_001020	NP_001011	P62249	RS16_HUMAN	ribosomal protein S16	87					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome			skin(1)	1	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;4.14e-26)|all cancers(26;2.68e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TTTGGAGATGGACTGACGGAT	0.547													47	63					0	0	0.000781405	0	0
CYP2S1	29785	broad.mit.edu	37	19	41703762	41703762	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:41703762G>A	uc002opw.2	+	3	477	c.422G>A	c.(421-423)GGG>GAG	p.G141E	CYP2F1_uc010xvw.1_Intron|CYP2S1_uc010xvx.1_Intron	NM_030622	NP_085125	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S,	141					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			skin(1)	1						CTGGGCATGGGGAAGCGAGAA	0.622													26	26					0	0	0.00127121	0	0
PSG11	5680	broad.mit.edu	37	19	43522979	43522979	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:43522979C>T	uc002ovm.1	-	3	759	c.652G>A	c.(652-654)GAA>AAA	p.E218K	PSG11_uc002ouw.2_Missense_Mutation_p.E224K|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.E224K|PSG11_uc002ovn.1_Missense_Mutation_p.E224K|PSG11_uc002ovo.1_Missense_Mutation_p.E96K|PSG11_uc002ovp.1_Missense_Mutation_p.E96K	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	218	Ig-like C2-type 1.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TTCCATATTTCACATTCATAG	0.507													89	181					0	0	0.000781405	0	0
ZNF224	7767	broad.mit.edu	37	19	44610559	44610560	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:44610559_44610560CC>TA	uc002oyh.1	+	6	548_549	c.246_247CC>TA	c.(244-249)ATCCAA>ATTAAA	p.Q83K	uc002oyi.2_RNA	NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	83					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				GAGACAAGATCCAAACTGAGAT	0.411													7	22					0	0	6.4e-05	0	0
CEACAM16	388551	broad.mit.edu	37	19	45211244	45211244	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:45211244A>T	uc010xxd.1	+	6	1258	c.1052A>T	c.(1051-1053)TAC>TTC	p.Y351F	CEACAM16_uc002ozq.2_Missense_Mutation_p.Y410F	NM_001039213	NP_001034302	A7LI12	A7LI12_HUMAN	carcinoembryonic antigen-related cell adhesion	351										ovary(1)	1	Lung NSC(12;0.000698)|all_lung(12;0.002)	Prostate(69;0.0376)|Ovarian(192;0.231)				TACGCCTGGTACCGCGGGCCT	0.692													16	63					0	0	0.000958276	0	0
APOC4	346	broad.mit.edu	37	19	45448482	45448482	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:45448482C>T	uc002pag.1	+	3	344	c.304C>T	c.(304-306)CTC>TTC	p.L102F	APOC2_uc002pah.2_5'Flank	NM_001646	NP_001637	P55056	APOC4_HUMAN	apolipoprotein C-IV precursor	102					lipid metabolic process|positive regulation of sequestering of triglyceride|triglyceride homeostasis	high-density lipoprotein particle|very-low-density lipoprotein particle	lipid transporter activity			breast(1)	1	Lung NSC(12;0.00858)|all_lung(12;0.0197)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00334)|Epithelial(262;0.178)		GGCCTGGTTCCTCGAATCCAA	0.542													142	208					0	0	0.000781405	0	0
RELB	5971	broad.mit.edu	37	19	45515487	45515487	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:45515487C>T	uc002paj.1	+	5	583	c.457C>T	c.(457-459)CTT>TTT	p.L153F		NM_006509	NP_006500	Q01201	RELB_HUMAN	reticuloendotheliosis viral oncogene homolog B	153	RHD.					nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00986)		CGGCAGCATCCTTGGGGAGAG	0.756													17	33					0	0	0.00152264	0	0
PTGIR	5739	broad.mit.edu	37	19	47124806	47124806	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:47124806C>T	uc002pex.2	-	3	1005	c.892G>A	c.(892-894)GCT>ACT	p.A298T		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	298	Cytoplasmic (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	TGGAAGACAGCCTTGCGGAAA	0.637													30	35					0	0	0.00178596	0	0
C5AR1	728	broad.mit.edu	37	19	47823574	47823574	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:47823574G>C	uc002pgj.1	+	2	589	c.540G>C	c.(538-540)GAG>GAC	p.E180D		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	180	Extracellular (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		TCCGGGAGGAGTACTTTCCAC	0.647													46	79					0	0	0.000781405	0	0
EHD2	30846	broad.mit.edu	37	19	48244619	48244619	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:48244619G>A	uc002phj.3	+	6	1812	c.1562G>A	c.(1561-1563)GGG>GAG	p.G521E	EHD2_uc010xyu.1_Missense_Mutation_p.G385E|EHD2_uc010xyv.1_Missense_Mutation_p.G204E	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	521	EH.				blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		GAAGGCCACGGGCTGCCCGCC	0.697													5	10					0	0	0.000602214	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48523119	48523119	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:48523119T>A	uc002pht.2	+	5	654	c.499T>A	c.(499-501)TTC>ATC	p.F167I		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor	167	Fibronectin type-II 3.				single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		AAAGTGGAGTTTCTGTGCCGA	0.398													15	26					0	0	0.000422831	0	0
TRPM4	54795	broad.mit.edu	37	19	49671865	49671865	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:49671865T>G	uc002pmw.2	+	6	740	c.668T>G	c.(667-669)TTT>TGT	p.F223C	TRPM4_uc010emu.2_Missense_Mutation_p.F223C|TRPM4_uc010yak.1_5'UTR|TRPM4_uc002pmx.2_Missense_Mutation_p.F49C|TRPM4_uc010emv.2_Missense_Mutation_p.F108C|TRPM4_uc010yal.1_5'UTR	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	223	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGGGTCCAGTTTCCCCTGGAC	0.592													9	23					0	0	0.000673444	0	0
ZNF473	25888	broad.mit.edu	37	19	50550097	50550097	+	Silent	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:50550097A>G	uc002prn.2	+	5	2634	c.2397A>G	c.(2395-2397)GCA>GCG	p.A799A	ZNF473_uc002prm.2_Silent_p.A799A|ZNF473_uc010ybo.1_Silent_p.A787A	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	799	C2H2-type 18.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		CCCAGAAAGCAAATCTAACAC	0.507											OREG0025632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	32					0	0	0.00185496	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022446	51022446	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:51022446G>A	uc002pss.2	-	3	661	c.524C>T	c.(523-525)TCC>TTC	p.S175F		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	175	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GAAGGCGTAGGAGGGGATGCT	0.657													14	22					0	0	0.000308642	0	0
GPR32	2854	broad.mit.edu	37	19	51274719	51274719	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:51274719G>A	uc010ycf.1	+	1	862	c.862G>A	c.(862-864)GAA>AAA	p.E288K		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	288	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GATGCTCAAGGAAATCTACCA	0.567													17	41					0	0	0.000566183	0	0
KLK3	354	broad.mit.edu	37	19	51358246	51358246	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:51358246T>G	uc002pts.1	+	1	76	c.35T>G	c.(34-36)GTG>GGG	p.V12G	KLK3_uc002ptp.1_Missense_Mutation_p.V12G|KLK3_uc010ycj.1_Missense_Mutation_p.V12G|KLK3_uc002ptr.1_Missense_Mutation_p.V12G|KLK3_uc010eof.1_RNA	NM_001030047	NP_001025218	P07288	KLK3_HUMAN	prostate specific antigen isoform 3	12					negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		ACCCTGTCCGTGACGTGGATT	0.647													10	26					0	0	0.000978159	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51918465	51918465	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:51918465G>A	uc002pwo.2	-	7	1916	c.1300C>T	c.(1300-1302)CAG>TAG	p.Q434*	SIGLEC10_uc002pwp.2_Nonsense_Mutation_p.Q376*|SIGLEC10_uc002pwq.2_Nonsense_Mutation_p.Q376*|SIGLEC10_uc002pwr.2_Nonsense_Mutation_p.Q434*|SIGLEC10_uc010ycy.1_Nonsense_Mutation_p.Q344*|SIGLEC10_uc010ycz.1_Nonsense_Mutation_p.Q386*|SIGLEC10_uc010eow.2_Nonsense_Mutation_p.Q246*|SIGLEC10_uc002pws.1_Nonsense_Mutation_p.Q270*	NM_033130	NP_149121	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10 precursor	434	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GAGACGTGCTGGGAGCCCAGT	0.672													25	23					0	0	0.00127121	0	0
ZNF614	80110	broad.mit.edu	37	19	52519474	52519474	+	Silent	SNP	T	C	C	rs73934727		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:52519474T>C	uc002pyj.2	-	5	1779	c.1377A>G	c.(1375-1377)GAA>GAG	p.E459E	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_Silent_p.E162E	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	459	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CTTTACCACATTCATTGCATT	0.403													34	62					0	0	0.00058488	0	0
ZNF610	162963	broad.mit.edu	37	19	52869701	52869701	+	Missense_Mutation	SNP	C	T	T	rs148016576	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:52869701C>T	uc002pyx.3	+	6	1476	c.1070C>T	c.(1069-1071)TCA>TTA	p.S357L	ZNF610_uc002pyy.3_Missense_Mutation_p.S357L|ZNF610_uc002pyz.3_Missense_Mutation_p.S314L|ZNF610_uc002pza.2_Missense_Mutation_p.S357L	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	357	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		AGTCTGCTTTCATACCTTGCA	0.423													21	49					0	0	0.00047179	0	0
ZNF610	162963	broad.mit.edu	37	19	52869803	52869803	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:52869803T>A	uc002pyx.3	+	6	1578	c.1172T>A	c.(1171-1173)CTT>CAT	p.L391H	ZNF610_uc002pyy.3_Missense_Mutation_p.L391H|ZNF610_uc002pyz.3_Missense_Mutation_p.L348H|ZNF610_uc002pza.2_Missense_Mutation_p.L391H	NM_001161426	NP_001154898	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610 isoform a	391	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		ATGGCCCATCTTCTAATCCAT	0.413													17	35					0	0	0.00074312	0	0
ZNF578	147660	broad.mit.edu	37	19	53015010	53015010	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:53015010A>T	uc002pzp.3	+	6	1620	c.1376A>T	c.(1375-1377)GAA>GTA	p.E459V		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	234	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		AAATGTGAAGAATGTGACAGA	0.383													27	35					0	0	0.00106085	0	0
ZNF816A	125893	broad.mit.edu	37	19	53454809	53454809	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:53454809G>A	uc002qal.1	-	5	520	c.219C>T	c.(217-219)TTC>TTT	p.F73F	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Silent_p.F57F	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	73	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TGGTTGATGAGAACTCCATCA	0.353													36	52					0	0	0.00128727	0	0
ZNF415	55786	broad.mit.edu	37	19	53612696	53612696	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:53612696G>A	uc002qax.2	-	7	1095	c.746C>T	c.(745-747)TCA>TTA	p.S249L	ZNF415_uc002qat.2_Missense_Mutation_p.S213L|ZNF415_uc002qaw.2_Missense_Mutation_p.S201L|ZNF415_uc010yds.1_Missense_Mutation_p.S201L|ZNF415_uc010ydt.1_Missense_Mutation_p.S201L|ZNF415_uc002qau.2_Missense_Mutation_p.S188L|ZNF415_uc002qav.2_Missense_Mutation_p.S213L|ZNF415_uc002qba.2_5'UTR|ZNF415_uc002qay.2_Missense_Mutation_p.S188L|ZNF415_uc002qaz.2_Missense_Mutation_p.S249L	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	249					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		TGTGAGTAATGAAGAACAGAT	0.383													25	54					0	0	0.000375601	0	0
ZNF813	126017	broad.mit.edu	37	19	53994194	53994194	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:53994194C>T	uc002qbu.2	+	4	836	c.708C>T	c.(706-708)ATC>ATT	p.I236I	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	236	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ATCAAATAATCCATTTAGGAG	0.388													31	57					0	0	0.001512	0	0
ZNF813	126017	broad.mit.edu	37	19	53994690	53994690	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:53994690C>T	uc002qbu.2	+	4	1332	c.1204C>T	c.(1204-1206)CGT>TGT	p.R402C	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	402	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TAAATGCCATCGTAGACTTCA	0.408													24	27					0	0	0.00047179	0	0
ZNF813	126017	broad.mit.edu	37	19	53995275	53995275	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:53995275C>T	uc002qbu.2	+	4	1917	c.1789C>T	c.(1789-1791)CAT>TAT	p.H597Y	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	597	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CCTTGCACGTCATCATAGACT	0.378													11	11					0	0	0.000978159	0	0
MIR1283-1	100302265	broad.mit.edu	37	19	54191781	54191781	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:54191781G>A	hsa-mir-1283-1|MI0003832	+			c.47G>A			MIR520A_hsa-mir-520a|MI0003149_5'Flank																	0						TTGTCAGAAAGAAGAGAAAGC	0.423													20	40					0	0	0.00229938	0	0
MIR516B2	574485	broad.mit.edu	37	19	54228779	54228779	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:54228779G>A	hsa-mir-516b-2|MI0003167	+			c.84G>A			MIR526A2_hsa-mir-526a-2|MI0003168_5'Flank																	0						TACTCTTTGAGAAAAGCAGCA	0.378													9	15					0	0	0.000274275	0	0
NLRP12	91662	broad.mit.edu	37	19	54313043	54313043	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:54313043C>T	uc002qch.3	-	3	2090	c.1870G>A	c.(1870-1872)GAG>AAG	p.E624K	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.E624K|NLRP12_uc002qcj.3_Missense_Mutation_p.E624K|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.E624K	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	624					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TGGATAAACTCCTCCTCCTGG	0.567													22	42					0	0	0.00229938	0	0
PRKCG	5582	broad.mit.edu	37	19	54395856	54395856	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:54395856C>T	uc002qcq.1	+	7	1062	c.780C>T	c.(778-780)TCC>TCT	p.S260S	PRKCG_uc010eqz.1_Silent_p.S260S|PRKCG_uc010yef.1_Silent_p.S260S|PRKCG_uc010yeg.1_Silent_p.S260S|PRKCG_uc010yeh.1_Silent_p.S147S	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	260	C2.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		GGGCCATGTCCTTTGGCGTCT	0.647													12	24					0	0	0.00185496	0	0
LILRA3	11026	broad.mit.edu	37	19	54802162	54802162	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:54802162C>T	uc002qfd.2	-	6	1091	c.1026G>A	c.(1024-1026)GTG>GTA	p.V342V	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.V278V	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	342	Ig-like C2-type 4.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACAGCAGGGTCACGTTCTCTC	0.607													10	31					0	0	0.000673444	0	0
LILRA1	11024	broad.mit.edu	37	19	55107840	55107840	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:55107840T>G	uc002qgh.1	+	7	1327	c.1145T>G	c.(1144-1146)TTC>TGC	p.F382C	LILRA2_uc010yfg.1_Missense_Mutation_p.F380C|LILRA1_uc010yfh.1_Missense_Mutation_p.F382C	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	382	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CAGGCTGAATTCCCTATGAGT	0.582													28	79					0	0	0.001512	0	0
LILRB1	10859	broad.mit.edu	37	19	55143065	55143065	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:55143065G>A	uc002qgj.2	+	5	525	c.185G>A	c.(184-186)AGA>AAA	p.R62K	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.R62K|LILRB1_uc002qgk.2_Missense_Mutation_p.R62K|LILRB1_uc002qgm.2_Missense_Mutation_p.R62K|LILRB1_uc010erq.2_Missense_Mutation_p.R62K|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	62	Ig-like C2-type 1.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CGTCTATATAGAGAAAAGAAA	0.582										HNSCC(37;0.09)			36	51					0	0	0.000692331	0	0
LILRB1	10859	broad.mit.edu	37	19	55143137	55143137	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:55143137C>T	uc002qgj.2	+	5	597	c.257C>T	c.(256-258)CCA>CTA	p.P86L	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Missense_Mutation_p.P86L|LILRB1_uc002qgk.2_Missense_Mutation_p.P86L|LILRB1_uc002qgm.2_Missense_Mutation_p.P86L|LILRB1_uc010erq.2_Missense_Mutation_p.P86L|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	86	Ig-like C2-type 1.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		TTCCCCATCCCATCCATCACC	0.552										HNSCC(37;0.09)			25	41					0	0	0.000720815	0	0
NLRP9	338321	broad.mit.edu	37	19	56249473	56249473	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:56249473C>T	uc002qly.2	-	1	296	c.268G>A	c.(268-270)GAA>AAA	p.E90K		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	90	DAPIN.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CTCATCTCTTCCTGAGCCTTT	0.498													191	313					0	0	0.000781405	0	0
NLRP13	126204	broad.mit.edu	37	19	56419288	56419288	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:56419288C>T	uc010ygg.1	-	7	2342	c.2317G>A	c.(2317-2319)GAC>AAC	p.D773N		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	773							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ATAATGAGGTCCTGCAGAACC	0.512													33	61					0	0	0.000953801	0	0
NLRP8	126205	broad.mit.edu	37	19	56466093	56466093	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:56466093G>A	uc002qmh.2	+	3	740	c.669G>A	c.(667-669)GTG>GTA	p.V223V	NLRP8_uc010etg.2_Silent_p.V223V	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	223	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CCAAAAAGGTGATGTTTGAGT	0.532													15	28					0	0	0.000219431	0	0
ZNF470	388566	broad.mit.edu	37	19	57085765	57085765	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:57085765T>C	uc002qnl.3	+	4	739	c.63T>C	c.(61-63)GGT>GGC	p.G21G	ZNF470_uc010etn.2_RNA	NM_001001668	NP_001001668	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		CATTTTAGGGTTCAGTGACTT	0.403													15	42					0	0	0.00074312	0	0
ZNF835	90485	broad.mit.edu	37	19	57175912	57175912	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:57175912C>T	uc010ygo.1	-	2	721	c.721G>A	c.(721-723)GAG>AAG	p.E241K	ZNF835_uc010ygn.1_Missense_Mutation_p.E219K	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						TAGGGCCGCTCGCCCGTGTGC	0.711													8	2					0	0	0.000274275	0	0
PEG3	5178	broad.mit.edu	37	19	57328369	57328369	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:57328369C>T	uc002qnu.2	-	7	1792	c.1441G>A	c.(1441-1443)GAG>AAG	p.E481K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E452K|PEG3_uc002qnv.2_Missense_Mutation_p.E481K|PEG3_uc002qnw.2_Missense_Mutation_p.E357K|PEG3_uc002qnx.2_Missense_Mutation_p.E355K|PEG3_uc010etr.2_Missense_Mutation_p.E481K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	481					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCACCATACTCATAGAGGTTC	0.453													38	78					0	0	0.000692331	0	0
USP29	57663	broad.mit.edu	37	19	57640096	57640096	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:57640096G>A	uc002qny.2	+	4	409	c.53G>A	c.(52-54)GGG>GAG	p.G18E		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	18					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAGAAGACTGGGATGACTAAG	0.343													22	31					0	0	0.000375601	0	0
ZIM3	114026	broad.mit.edu	37	19	57648328	57648328	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:57648328T>A	uc002qnz.1	-	4	540	c.154A>T	c.(154-156)ACC>TCC	p.T52S		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGTTTGGTGGTTTCCCCTTGT	0.378													17	43					0	0	0.00121646	0	0
ZNF17	7565	broad.mit.edu	37	19	57931998	57931998	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:57931998C>T	uc002qoo.1	+	3	1369	c.1138C>T	c.(1138-1140)CAT>TAT	p.H380Y	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Missense_Mutation_p.H382Y	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	380	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		CCAGAGAGTTCATACTGGAGA	0.398													39	56					0	0	0.00195071	0	0
ZNF749	388567	broad.mit.edu	37	19	57955450	57955450	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:57955450C>T	uc002qoq.2	+	3	1188	c.934C>T	c.(934-936)CAT>TAT	p.H312Y	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	312	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TACACAGGCTCATCTGGTTGG	0.438													20	36					0	0	0.00188189	0	0
ZNF549	256051	broad.mit.edu	37	19	58046568	58046568	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:58046568C>T	uc002qpb.1	+	3	378	c.129C>T	c.(127-129)CTC>CTT	p.L43L	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Silent_p.L43L|ZNF549_uc002qpa.1_Silent_p.L30L	NM_153263	NP_694995	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	43	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGTGGGGCCTCCTTGATGAAG	0.493													31	58					0	0	0.001512	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58549234	58549234	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:58549234C>T	uc002qrc.1	+	3	277	c.30C>T	c.(28-30)TCC>TCT	p.S10S	ZSCAN1_uc002qra.1_Silent_p.S10S|ZSCAN1_uc002qrb.1_Silent_p.S10S	NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	10					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCCCTGCCTCCCCCAGACGCC	0.677													5	1					0	0	0.000602214	0	0
ZNF135	7694	broad.mit.edu	37	19	58578608	58578608	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:58578608G>A	uc010yhq.1	+	5	888	c.792G>A	c.(790-792)CGG>CGA	p.R264R	ZNF135_uc002qre.2_Silent_p.R252R|ZNF135_uc002qrd.1_Silent_p.R210R|ZNF135_uc002qrf.2_Silent_p.R210R|ZNF135_uc002qrg.2_Silent_p.R222R|ZNF135_uc010yhr.1_Silent_p.R73R	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	264					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AAGGCTTCCGGAACAGCTCGG	0.507													43	68					0	0	0.000589545	0	0
ZNF544	27300	broad.mit.edu	37	19	58772667	58772667	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:58772667G>A	uc010euo.2	+	7	1169	c.695G>A	c.(694-696)GGA>GAA	p.G232E	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.G204E|ZNF544_uc010yhy.1_Missense_Mutation_p.G204E|ZNF544_uc002qrt.3_Missense_Mutation_p.G90E|ZNF544_uc002qru.3_Missense_Mutation_p.G90E|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AGTAAACTTGGAAACGTTGAA	0.383													36	50					0	0	0.000692331	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010865	59010865	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr19:59010865G>A	uc002qtc.2	-	7	1771	c.1661C>T	c.(1660-1662)ACC>ATC	p.T554I	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	554	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GGACCGGAAGGTGTCCCCGAG	0.657													19	25					0	0	0.000375601	0	0
NT5C1B	93034	broad.mit.edu	37	2	18757621	18757621	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:18757621C>T	uc002rcz.2	-	9	1442	c.1338G>A	c.(1336-1338)GCG>GCA	p.A446A	NT5C1B_uc002rcy.2_Silent_p.A446A|NT5C1B_uc010exr.2_Silent_p.A388A|NT5C1B_uc010yju.1_Silent_p.A386A|NT5C1B_uc002rda.2_Silent_p.A386A|NT5C1B_uc010yjv.1_Silent_p.A463A|NT5C1B_uc010yjw.1_Silent_p.A429A|NT5C1B_uc010exs.2_Silent_p.A448A	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	446					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CAAACATTGTCGCAGAGGCAA	0.363													9	35					0	0	0.000274275	0	0
MATN3	4148	broad.mit.edu	37	2	20202958	20202958	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:20202958C>T	uc002rdl.2	-	3	943	c.880G>A	c.(880-882)GGA>AGA	p.G294R	MATN3_uc010exu.1_Intron	NM_002381	NP_002372	O15232	MATN3_HUMAN	matrilin 3 precursor	294	EGF-like 1.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGGTGTATCCTTGGCTACAC	0.542													19	29					0	0	0.00074312	0	0
PUM2	23369	broad.mit.edu	37	2	20455081	20455081	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:20455081G>A	uc002rds.1	-	17	2667	c.2644C>T	c.(2644-2646)CCT>TCT	p.P882S	PUM2_uc002rdq.1_Missense_Mutation_p.P261S|PUM2_uc002rdt.1_Missense_Mutation_p.P882S|PUM2_uc002rdr.2_Missense_Mutation_p.P742S|PUM2_uc010yjy.1_Missense_Mutation_p.P803S|PUM2_uc002rdu.1_Missense_Mutation_p.P882S|PUM2_uc010yjz.1_Missense_Mutation_p.P821S	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	884	Pumilio 5.|PUM-HD.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCCATAAGGATGAGTTGAA	0.388													23	28					0	0	0.000586117	0	0
RHOB	388	broad.mit.edu	37	2	20647414	20647414	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:20647414A>C	uc002rdv.2	+	1	580	c.188A>C	c.(187-189)CAG>CCG	p.Q63P		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	63	GTP (By similarity).				angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		ACGGCGGGCCAGGAGGACTAC	0.647													17	37					0	0	0.000566183	0	0
APOB	338	broad.mit.edu	37	2	21231795	21231795	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:21231795C>T	uc002red.2	-	26	8073	c.7945G>A	c.(7945-7947)GAA>AAA	p.E2649K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2649					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATGGTAAATTCTGGTGTGGAA	0.353													188	313					0	0	0.000781405	0	0
TRIM54	57159	broad.mit.edu	37	2	27521592	27521592	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:27521592A>G	uc002rjo.2	+	2	326	c.326A>G	c.(325-327)AAG>AGG	p.K109R	TRIM54_uc002rjn.2_Missense_Mutation_p.K109R	NM_187841	NP_912730	Q9BYV2	TRI54_HUMAN	ring finger protein 30 isoform 2	109					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACATTTACAAGCAGGAGTCA	0.547													12	18					0	0	0.000308642	0	0
MPV17	4358	broad.mit.edu	37	2	27535421	27535421	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:27535421G>A	uc002rjr.2	-	4	362	c.315C>T	c.(313-315)CTC>CTT	p.L105L	MPV17_uc002rjq.2_Silent_p.L105L|MPV17_uc002rjs.2_Silent_p.L105L|MPV17_uc002rjt.2_RNA	NM_002437	NP_002428	P39210	MPV17_HUMAN	Mpv17 protein	105	Helical; (Potential).				cellular response to reactive oxygen species|glomerular basement membrane development|homeostatic process|inner ear development|mitochondrial genome maintenance|regulation of reactive oxygen species metabolic process	integral to peroxisomal membrane|mitochondrial inner membrane					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTACCAGTGGGAGAAAGCAGC	0.567													25	51					0	0	0.000878237	0	0
ALK	238	broad.mit.edu	37	2	29917784	29917784	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:29917784G>A	uc002rmy.2	-	3	1791	c.884C>T	c.(883-885)TCC>TTC	p.S295F		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	295	MAM 1.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GGCCTCCTCGGAGGGGATGCG	0.617			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				31	67					0	0	0.000692331	0	0
HEATR5B	54497	broad.mit.edu	37	2	37234374	37234374	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:37234374G>A	uc002rpp.1	-	29	4692	c.4596C>T	c.(4594-4596)CTC>CTT	p.L1532L	HEATR5B_uc010ezy.1_Silent_p.L116L	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1532							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				CCACCGCATGGAGAATTGGGG	0.408													31	63					0	0	0.000692331	0	0
QPCT	25797	broad.mit.edu	37	2	37586815	37586815	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:37586815C>T	uc002rqg.2	+	3	482	c.360C>T	c.(358-360)TTC>TTT	p.F120F	QPCT_uc002rqh.2_Silent_p.F71F	NM_012413	NP_036545	Q16769	QPCT_HUMAN	glutaminyl-peptide cyclotransferase precursor	120					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	extracellular region	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|zinc ion binding			central_nervous_system(1)	1		Ovarian(717;0.051)|all_hematologic(82;0.21)				ACCGGTCTTTCTCAAATATCA	0.478													19	26					0	0	0.00074312	0	0
THADA	63892	broad.mit.edu	37	2	43520056	43520057	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:43520056_43520057CC>AA	uc002rsw.3	-	32	5086_5087	c.4734_4735GG>TT	c.(4732-4737)AAGGGC>AATTGC	p.1578_1579KG>NC	THADA_uc010far.2_Missense_Mutation_p.773_774KG>NC|THADA_uc002rsx.3_Missense_Mutation_p.1578_1579KG>NC|THADA_uc002rsy.3_RNA	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1578_1579							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GGTGGCACGCCCTTCTCTCCAA	0.495													12	395					0	0	6.4e-05	0	0
DYNC2LI1	51626	broad.mit.edu	37	2	44016840	44016840	+	Silent	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:44016840C>A	uc002rtk.2	+	5	396	c.300C>A	c.(298-300)CCC>CCA	p.P100P	DYNC2LI1_uc002rth.2_Silent_p.P100P|DYNC2LI1_uc002rti.2_Silent_p.P100P|DYNC2LI1_uc002rtj.2_Silent_p.P100P|DYNC2LI1_uc002rtl.2_Silent_p.P100P|DYNC2LI1_uc010ynz.1_5'UTR	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	100						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCAGCATACCCATCACAGGTG	0.423													9	354					0.000978159	0.00402107	0.000978159	1	0
SEMA4F	10505	broad.mit.edu	37	2	74902382	74902382	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:74902382G>A	uc002sna.1	+	10	1354	c.1243G>A	c.(1243-1245)GAC>AAC	p.D415N	SEMA4F_uc010ffq.1_Missense_Mutation_p.D382N|SEMA4F_uc010ffr.1_Missense_Mutation_p.D27N|SEMA4F_uc002snb.1_Missense_Mutation_p.D27N|SEMA4F_uc002snc.1_Missense_Mutation_p.D260N	NM_004263	NP_004254	O95754	SEM4F_HUMAN	semaphorin W precursor	415	Sema.|Extracellular (Potential).				cell-cell signaling	endoplasmic reticulum|integral to plasma membrane	receptor activity			ovary(2)|pancreas(1)|skin(1)	4						CCCACTCATGGACAGGCCAGT	0.582											OREG0014721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	25					0	0	0.000958276	0	0
DNAH6	1768	broad.mit.edu	37	2	84780120	84780120	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:84780120C>T	uc010fgb.2	+	10	1701	c.1564C>T	c.(1564-1566)CAG>TAG	p.Q522*	DNAH6_uc002soo.2_Nonsense_Mutation_p.Q101*|DNAH6_uc002sop.2_Nonsense_Mutation_p.Q101*	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	522	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						GTTGACAGTCCAGTCACTGCT	0.408													46	73					0	0	0.000781405	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554604	85554604	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:85554604G>A	uc010fgd.1	-	2	540	c.251C>T	c.(250-252)TCG>TTG	p.S84L	TGOLN2_uc002soz.2_Missense_Mutation_p.S84L|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Missense_Mutation_p.S84L|TGOLN2_uc002spc.1_Missense_Mutation_p.S84L	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	84	Extracellular (Potential).|14 X 14 AA tandem repeats.|3.					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						CTCCGCACCCGACTTGTTGGG	0.602													86	155					0	0	0.000781405	0	0
SMYD1	150572	broad.mit.edu	37	2	88393054	88393054	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:88393054C>T	uc002ssr.2	+	5	680	c.678C>T	c.(676-678)TCC>TCT	p.S226S	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_Intron	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	226	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						CAGTGAAATCCATGTTTCATA	0.493													20	60					0	0	0.00188189	0	0
Unknown	0	broad.mit.edu	37	2	89399622	89399622	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:89399622G>A	uc010ytr.1	-	46		c.4823C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		ATGGAGACTGGGTCATCTGGA	0.438													43	69					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	2	91679133	91679133	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:91679133G>A	uc010yua.1	+	1		c.47G>A								Homo sapiens clone CIC 03 anticardiolipin immunoglobulin light chain mRNA, partial cds.																		GCATCTGTAGGAGACAGAGTC	0.438													18	223					0	0	0.00209593	0	0
Unknown	0	broad.mit.edu	37	2	95552769	95552769	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:95552769C>T	uc002stv.1	-	7		c.821G>A								Homo sapiens cDNA FLJ44118 fis, clone TESTI4047069.																		TCAATTCCTCCTTTGTCATAA	0.393													6	10					0	0	0.00116845	0	0
KIAA1310	55683	broad.mit.edu	37	2	97278298	97278298	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:97278298G>A	uc002swn.3	-	8	1061	c.915C>T	c.(913-915)GTC>GTT	p.V305V	KIAA1310_uc002swh.3_Silent_p.V193V|KIAA1310_uc002swi.3_Silent_p.V206V|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Silent_p.V218V|KIAA1310_uc010fhz.2_Silent_p.V99V|KIAA1310_uc002swl.3_Silent_p.V206V|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Silent_p.V99V|KIAA1310_uc002swp.1_Silent_p.V206V|KIAA1310_uc002swq.1_Silent_p.V77V|KIAA1310_uc010fhy.1_Silent_p.V206V	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	305											0						CTACAGGGATGACCTGAAGGA	0.473													28	46					0	0	0.00127121	0	0
KIAA1310	55683	broad.mit.edu	37	2	97279279	97279279	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:97279279G>A	uc002swn.3	-	6	887	c.741C>T	c.(739-741)CTC>CTT	p.L247L	KIAA1310_uc002swh.3_Silent_p.L135L|KIAA1310_uc002swi.3_Silent_p.L148L|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Silent_p.L160L|KIAA1310_uc010fhz.2_Silent_p.L41L|KIAA1310_uc002swl.3_Silent_p.L148L|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Silent_p.L41L|KIAA1310_uc002swp.1_Silent_p.L148L|KIAA1310_uc002swq.1_Silent_p.L19L|KIAA1310_uc010fhy.1_Silent_p.L148L	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	247											0						TCTTCAGTAGGAGAGACAAGG	0.468													31	58					0	0	0.00058488	0	0
SEMA4C	54910	broad.mit.edu	37	2	97530946	97530946	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:97530946A>G	uc002sxh.3	-	7	789	c.629T>C	c.(628-630)CTC>CCC	p.L210P	SEMA4C_uc002sxf.3_5'Flank|SEMA4C_uc002sxe.2_5'Flank|SEMA4C_uc002sxg.3_Missense_Mutation_p.L263P	NM_017789	NP_060259	Q9C0C4	SEM4C_HUMAN	semaphorin 4C precursor	210	Extracellular (Potential).|Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			skin(2)	2						CTCACCGTTGAGCCAAAAGGC	0.637													8	13					0	0	0.000157383	0	0
MRPL30	51263	broad.mit.edu	37	2	99812098	99812098	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:99812098T>A	uc002szu.2	+	6	578	c.416T>A	c.(415-417)CTC>CAC	p.L139H	MRPL30_uc002szl.1_RNA|MRPL30_uc002szt.1_RNA|MRPL30_uc002szv.2_Missense_Mutation_p.L139H	NM_145213	NP_660214	Q8TCC3	RM30_HUMAN	RecName: Full=39S ribosomal protein L30, mitochondrial;          Short=L30mt; AltName: Full=MRP-L30; AltName: Full=MRP-L28; Flags: Precursor;	139					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1						AACACGTGCCTCAAAAGCACT	0.448													41	75					0	0	0.00195071	0	0
EIF5B	9669	broad.mit.edu	37	2	99977974	99977974	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:99977974C>T	uc002tab.2	+	4	794	c.610C>T	c.(610-612)CAG>TAG	p.Q204*		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	204					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						GAAAAAAAATCAGAAAAACAA	0.358													10	26					0	0	0.000978159	0	0
MRPS9	64965	broad.mit.edu	37	2	105713766	105713766	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:105713766C>T	uc002tcn.3	+	10	1151	c.1083C>T	c.(1081-1083)GTC>GTT	p.V361V		NM_182640	NP_872578	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9 precursor	361					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						AGGACGAGGTCGAGTGGATGA	0.557													7	26					0	0	0.00198382	0	0
EDAR	10913	broad.mit.edu	37	2	109546615	109546615	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:109546615C>T	uc002teq.3	-	3	566	c.135G>A	c.(133-135)CAG>CAA	p.Q45Q	EDAR_uc010fjn.2_Silent_p.Q45Q|EDAR_uc010yws.1_Silent_p.Q45Q	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	45	TNFR-Cys 1.|Extracellular (Potential).				apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						GGGGGCACTCCTGGCACAGCC	0.637													6	16					0	0	0.000157383	0	0
TMEM37	140738	broad.mit.edu	37	2	120194596	120194596	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:120194596C>T	uc002tly.2	+	2	187	c.153C>T	c.(151-153)CTC>CTT	p.L51L		NM_183240	NP_899063	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	51						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)	1						GGCACTGGCTCCTGGCTGAGG	0.622													40	64					0	0	0.00170553	0	0
MYO7B	4648	broad.mit.edu	37	2	128367259	128367259	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:128367259T>C	uc002top.2	+	23	3046	c.2993T>C	c.(2992-2994)TTG>TCG	p.L998S		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	998	MyTH4 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGATACCCGTTGCTTTACCAC	0.587													29	61					0	0	0.00148497	0	0
MYO7B	4648	broad.mit.edu	37	2	128390866	128390866	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:128390866G>A	uc002top.2	+	39	5414	c.5361G>A	c.(5359-5361)GTG>GTA	p.V1787V	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1787	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGCACCAGGTGGAGGTGGAGG	0.672													7	18					0	0	0.000274275	0	0
POTEF	728378	broad.mit.edu	37	2	130878044	130878044	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:130878044C>T	uc010fmh.2	-	3	445	c.45G>A	c.(43-45)AAG>AAA	p.K15K		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	15						cell cortex	ATP binding			skin(3)|ovary(2)	5						CAAATGGCTTCTTCACAGAAG	0.562													32	50					0	0	0.000781405	0	0
FAM123C	205147	broad.mit.edu	37	2	131519914	131519914	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:131519914G>A	uc002trw.2	+	2	459	c.269G>A	c.(268-270)CGA>CAA	p.R90Q	FAM123C_uc010fmv.2_Missense_Mutation_p.R90Q|FAM123C_uc010fms.1_Missense_Mutation_p.R90Q|FAM123C_uc010fmt.1_Missense_Mutation_p.R90Q|FAM123C_uc010fmu.1_Missense_Mutation_p.R90Q	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	90										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AAACCGGTGCGAAAGTGCAAG	0.662													5	13					0	0	0.000602214	0	0
LYPD1	116372	broad.mit.edu	37	2	133403686	133403686	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:133403686C>T	uc002ttn.2	-	3	1334	c.358G>A	c.(358-360)GCC>ACC	p.A120T	GPR39_uc002ttl.2_3'UTR|LYPD1_uc002ttm.3_Missense_Mutation_p.A136T|LYPD1_uc002tto.2_Missense_Mutation_p.A68T	NM_144586	NP_653187	Q8N2G4	LYPD1_HUMAN	LY6/PLAUR domain containing 1 isoform a	120						anchored to membrane|plasma membrane					0						GGCCTGAGGGCCGAGGCAGAA	0.577													12	37					0	0	0.000219431	0	0
YSK4	80122	broad.mit.edu	37	2	135743570	135743570	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:135743570C>T	uc002tue.1	-	7	2903	c.2872G>A	c.(2872-2874)GAC>AAC	p.D958N	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.D845N|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.D686N|YSK4_uc002tui.3_Missense_Mutation_p.D975N	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	958							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTTACAGAGTCCATAATTTCT	0.308													14	31					0	0	0.00185496	0	0
YSK4	80122	broad.mit.edu	37	2	135744273	135744273	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:135744273C>T	uc002tue.1	-	7	2200	c.2169G>A	c.(2167-2169)ATG>ATA	p.M723I	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.M610I|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.M451I|YSK4_uc002tui.3_Missense_Mutation_p.M740I	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	723							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTGGGCATTTCATATGTGTTT	0.388													54	79					0	0	0.000781405	0	0
YSK4	80122	broad.mit.edu	37	2	135779399	135779399	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:135779399T>G	uc002tue.1	-	2	55	c.24A>C	c.(22-24)GAA>GAC	p.E8D	YSK4_uc010fne.1_5'UTR|YSK4_uc002tuf.1_Missense_Mutation_p.E8D|YSK4_uc010fnc.1_Missense_Mutation_p.E8D|YSK4_uc010fnd.1_Missense_Mutation_p.E8D|YSK4_uc010zbg.1_Missense_Mutation_p.E8D|YSK4_uc002tui.3_Missense_Mutation_p.E25D	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	8							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CAGCATGTCTTTCTATCAAAA	0.328													22	49					0	0	0.00188189	0	0
THSD7B	80731	broad.mit.edu	37	2	138400065	138400065	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:138400065G>A	uc002tva.1	+	20	3720	c.3720G>A	c.(3718-3720)ATG>ATA	p.M1240I	THSD7B_uc010zbj.1_Intron	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TAGGTCGAATGAGCCGGACTC	0.483													36	83					0	0	0.00111076	0	0
FMNL2	114793	broad.mit.edu	37	2	153405583	153405583	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:153405583G>A	uc002tye.2	+	4	698	c.331G>A	c.(331-333)GAA>AAA	p.E111K		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	111	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						AAGAGAACTGGAAATTTCTTT	0.343													9	19					0	0	0.000673444	0	0
FMNL2	114793	broad.mit.edu	37	2	153475610	153475610	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:153475610C>T	uc002tye.2	+	14	1932	c.1565C>T	c.(1564-1566)TCC>TTC	p.S522F	FMNL2_uc010fob.2_5'Flank|FMNL2_uc002tyf.2_5'Flank	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	522					actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						GGGGCCGCTTCCTCAGGACCC	0.572													10	19					0	0	0.000673444	0	0
PKP4	8502	broad.mit.edu	37	2	159522971	159522971	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:159522971C>T	uc002tzv.2	+	16	2884	c.2624C>T	c.(2623-2625)CCC>CTC	p.P875L	PKP4_uc002tzu.2_Missense_Mutation_p.P875L|PKP4_uc002tzw.2_Missense_Mutation_p.P875L|PKP4_uc002tzx.2_Missense_Mutation_p.P532L|PKP4_uc002uaa.2_Missense_Mutation_p.P727L|uc002uab.1_Intron|PKP4_uc002uac.2_Missense_Mutation_p.P56L|PKP4_uc002uad.2_RNA|PKP4_uc002uae.1_5'Flank	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	875	ARM 8.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						AAGGGGCTCCCCATCCTTGTG	0.463										HNSCC(62;0.18)			36	86					0	0	0.00111076	0	0
KCNH7	90134	broad.mit.edu	37	2	163393558	163393558	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:163393558G>A	uc002uch.1	-	3	552	c.340C>T	c.(340-342)CCA>TCA	p.P114S	KCNH7_uc002uci.2_Missense_Mutation_p.P114S	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	114	Cytoplasmic (Potential).|PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTTTTCACTGGAATTATGTGA	0.353													33	55					0	0	0.000814825	0	0
SCN1A	6323	broad.mit.edu	37	2	166859089	166859089	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:166859089G>A	uc010zcz.1	-	21	4162	c.4144C>T	c.(4144-4146)CAT>TAT	p.H1382Y	SCN1A_uc002udo.3_Missense_Mutation_p.H1262Y|SCN1A_uc010fpk.2_Missense_Mutation_p.H1234Y	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1393	III.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CAATCAGTATGATTATTCACG	0.363													24	39					0	0	0.000586117	0	0
SCN9A	6335	broad.mit.edu	37	2	167129157	167129157	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:167129157C>T	uc010fpl.2	-	17	3411	c.3070G>A	c.(3070-3072)GAA>AAA	p.E1024K	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1035						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	ATATAGTTTTCCTTCTTAGTA	0.353													18	34					0	0	0.00074312	0	0
SCN9A	6335	broad.mit.edu	37	2	167162390	167162390	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:167162390T>A	uc010fpl.2	-	5	849	c.508A>T	c.(508-510)AAA>TAA	p.K170*	SCN9A_uc002udr.1_Nonsense_Mutation_p.K41*|SCN9A_uc002uds.1_Nonsense_Mutation_p.K41*|SCN9A_uc002udt.1_Nonsense_Mutation_p.K41*	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	170	I.|Helical; Name=S2 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GCAAGGATTTTTACAAGTGAT	0.373													28	35					0	0	0.000720815	0	0
XIRP2	129446	broad.mit.edu	37	2	167759998	167759998	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:167759998C>T	uc002udx.2	+	1	24	c.6C>T	c.(4-6)TTC>TTT	p.F2F	XIRP2_uc010fpn.2_Silent_p.F2F|XIRP2_uc010fpo.2_Silent_p.F2F|XIRP2_uc010fpp.2_Silent_p.F2F	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CATCCATGTTCCCAATGCAGA	0.448													20	35					0	0	0.00047179	0	0
XIRP2	129446	broad.mit.edu	37	2	167760381	167760381	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:167760381C>T	uc002udx.2	+	1	407	c.389C>T	c.(388-390)CCA>CTA	p.P130L	XIRP2_uc010fpn.2_Missense_Mutation_p.P130L|XIRP2_uc010fpo.2_Missense_Mutation_p.P130L|XIRP2_uc010fpp.2_Missense_Mutation_p.P130L	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GGAAACAAACCAGCTGAGTAC	0.458													22	58					0	0	0.00047179	0	0
XIRP2	129446	broad.mit.edu	37	2	168099978	168099978	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:168099978G>A	uc002udx.2	+	8	2094	c.2076G>A	c.(2074-2076)GTG>GTA	p.V692V	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.V517V|XIRP2_uc010fpq.2_Silent_p.V470V|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	517	Xin 5.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCAAGACTGTGAGATACATGT	0.398													22	35					0	0	0.00188189	0	0
XIRP2	129446	broad.mit.edu	37	2	168108204	168108204	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:168108204G>A	uc002udx.2	+	8	10320	c.10302G>A	c.(10300-10302)ATG>ATA	p.M3434I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.M3259I|XIRP2_uc010fpq.2_Missense_Mutation_p.M3212I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3259				M -> V (in Ref. 8; CAD91139).	actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGTCGAAGATGAAAACCTCTT	0.448													34	29					0	0	0.000692331	0	0
CDCA7	83879	broad.mit.edu	37	2	174229542	174229542	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:174229542G>A	uc002uid.1	+	5	613	c.482G>A	c.(481-483)AGG>AAG	p.R161K	CDCA7_uc002uic.1_Missense_Mutation_p.R240K|CDCA7_uc010zej.1_Missense_Mutation_p.R196K|CDCA7_uc010zek.1_Missense_Mutation_p.R119K	NM_145810	NP_665809	Q9BWT1	CDCA7_HUMAN	cell division cycle associated 7 isoform 2	161	Arg-rich.				regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.116)			AGACCGCGAAGGCGTACATTC	0.488													24	56					0	0	0.00178596	0	0
CIR1	9541	broad.mit.edu	37	2	175243705	175243705	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:175243705G>A	uc002uim.2	-	7	523	c.430C>T	c.(430-432)CCT>TCT	p.P144S	CIR1_uc002uin.2_Silent_p.V8V|CIR1_uc002uio.2_5'UTR|CIR1_uc002uip.2_Missense_Mutation_p.P33S	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	144					mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						CCAAACAAAGGACATTCTCGA	0.403													27	53					0	0	0.000720815	0	0
TTN	7273	broad.mit.edu	37	2	179396101	179396101	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:179396101C>T	uc010zfg.1	-	307	97761	c.97537G>A	c.(97537-97539)GAA>AAA	p.E32513K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E26208K|TTN_uc010zfi.1_Missense_Mutation_p.E26141K|TTN_uc010zfj.1_Missense_Mutation_p.E26016K|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33440							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATTTCACTTCCCTGACAGAA	0.438													43	61					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179449470	179449471	+	Missense_Mutation	DNP	CG	AT	AT	rs141965360	by1000genomes	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:179449470_179449471CG>AT	uc010zfg.1	-	259	57417_57418	c.57193_57194CG>AT	c.(57193-57195)CGG>ATG	p.R19065M	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R12760M|TTN_uc010zfi.1_Missense_Mutation_p.R12693M|TTN_uc010zfj.1_Missense_Mutation_p.R12568M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19992							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCACGGACCCGGAAGATGTAC	0.49													6	231					0	0	6.4e-05	0	0
TTN	7273	broad.mit.edu	37	2	179580319	179580319	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:179580319C>T	uc010zfg.1	-	86	22314	c.22090G>A	c.(22090-22092)GAA>AAA	p.E7364K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E4025K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8291							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTGCATTTCCAGCACAGCC	0.458													15	35					0	0	0.000308642	0	0
TTN	7273	broad.mit.edu	37	2	179613668	179613668	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:179613668G>A	uc002unb.2	-	46	13683	c.13459C>T	c.(13459-13461)CAA>TAA	p.Q4487*	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCTTCTTTTGAGGAGGATTA	0.318													32	44					0	0	0.00178596	0	0
TTN	7273	broad.mit.edu	37	2	179634502	179634502	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:179634502G>A	uc010zfg.1	-	37	9030	c.8806C>T	c.(8806-8808)CAT>TAT	p.H2936Y	TTN_uc010zfh.1_Missense_Mutation_p.H2890Y|TTN_uc010zfi.1_Missense_Mutation_p.H2890Y|TTN_uc010zfj.1_Missense_Mutation_p.H2890Y|TTN_uc002unb.2_Missense_Mutation_p.H2936Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2936							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAGCTGATGGAGTTTTCCC	0.478													69	142					0	0	0.000781405	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802724	185802724	+	Silent	SNP	G	A	A	rs112021606	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:185802724G>A	uc002uph.2	+	4	3195	c.2601G>A	c.(2599-2601)AGG>AGA	p.R867R		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	867						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AAATCGAAAGGAACTCAGAAC	0.358													28	48					0	0	0.000878237	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187702078	187702078	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:187702078G>A	uc002upu.1	-	5	738	c.698C>T	c.(697-699)CCC>CTC	p.P233L		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	233	ZZ-type.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			GTTATTACAGGGAATCCCAAG	0.353													19	43					0	0	0.00121646	0	0
COL3A1	1281	broad.mit.edu	37	2	189862072	189862072	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:189862072G>A	uc002uqj.1	+	26	1943	c.1826G>A	c.(1825-1827)GGA>GAA	p.G609E		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	609	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTCCTCCTGGAAAGAATGGT	0.443													23	30					0	0	0.000586117	0	0
COL5A2	1290	broad.mit.edu	37	2	189904289	189904289	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:189904289C>T	uc002uqk.2	-	51	3909	c.3634G>A	c.(3634-3636)GGC>AGC	p.G1212S	COL5A2_uc010frx.2_Missense_Mutation_p.G788S	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1212					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAGGAGGGCCCTAATTAAAA	0.483													13	33					0	0	0.00185496	0	0
COL5A2	1290	broad.mit.edu	37	2	189943830	189943830	+	Missense_Mutation	SNP	C	T	T	rs142312726		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:189943830C>T	uc002uqk.2	-	15	1239	c.964G>A	c.(964-966)GAA>AAA	p.E322K	COL5A2_uc010frx.2_Missense_Mutation_p.E75K	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	322					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGGCCAGCTTCACCCTAAAAA	0.378													26	34					0	0	0.00178596	0	0
DNAH7	56171	broad.mit.edu	37	2	196682525	196682525	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:196682525G>A	uc002utj.3	-	50	9421	c.9320C>T	c.(9319-9321)CCT>CTT	p.P3107L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3107	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CATTCCCTCAGGGGTTATCAT	0.343													13	21					0	0	0.00185496	0	0
HECW2	57520	broad.mit.edu	37	2	197208412	197208412	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:197208412C>T	uc002utm.1	-	3	552	c.369G>A	c.(367-369)TGG>TGA	p.W123*	HECW2_uc002utl.1_5'UTR	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	123					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GCTCAATTCTCCATACAATTT	0.373													89	134					0	0	0.000781405	0	0
PLCL1	5334	broad.mit.edu	37	2	198949555	198949555	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:198949555C>T	uc010fsp.2	+	2	1605	c.1314C>T	c.(1312-1314)GGC>GGT	p.G438G	PLCL1_uc002uuv.3_Silent_p.G359G	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	438	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TGAAAATGGGCTGTCGAAGCG	0.413													28	47					0	0	0.00106085	0	0
ALS2CR12	130540	broad.mit.edu	37	2	202215474	202215474	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:202215474G>A	uc010ftg.2	-	3	589	c.145C>T	c.(145-147)CAC>TAC	p.H49Y	ALS2CR12_uc002uya.3_Missense_Mutation_p.H49Y|ALS2CR12_uc010fth.2_RNA	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	49					regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						AGGTAATTGTGATTTTTTGGA	0.274													15	23					0	0	0.00121646	0	0
SUMO1	7341	broad.mit.edu	37	2	203075522	203075522	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:203075522G>A	uc002uyz.1	-	4	321	c.173C>T	c.(172-174)CCA>CTA	p.P58L	SUMO1_uc002uza.1_Missense_Mutation_p.P33L	NM_001005781	NP_001005781	P63165	SUMO1_HUMAN	SMT3 suppressor of mif two 3 homolog 1 isoform a	58	Ubiquitin-like.				DNA repair|interferon-gamma-mediated signaling pathway|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|palate development|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein complex assembly|protein sumoylation|regulation of interferon-gamma-mediated signaling pathway|regulation of protein localization	cytoplasm|nuclear membrane|nuclear pore|nuclear speck	ubiquitin protein ligase binding				0						TGAATTCATTGGAACACCCTA	0.318													20	42					0	0	0.00152264	0	0
CPS1	1373	broad.mit.edu	37	2	211455618	211455619	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:211455618_211455619CC>TA	uc002vee.3	+	9	1067_1068	c.935_936CC>TA	c.(934-936)TCC>TTA	p.S312L	CPS1_uc010fur.2_Missense_Mutation_p.S318L|CPS1_uc010fus.2_5'Flank	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	312	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TACAAGATGTCCATGGCCAACA	0.406													34	70					0	0	6.4e-05	0	0
BCS1L	617	broad.mit.edu	37	2	219525811	219525811	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:219525811A>G	uc002vio.2	+	2	519	c.101A>G	c.(100-102)AAG>AGG	p.K34R	ZNF142_uc002vin.2_5'Flank|ZNF142_uc010fvt.2_5'Flank|ZNF142_uc002vim.2_5'Flank|BCS1L_uc002vip.2_Missense_Mutation_p.K34R|BCS1L_uc002viq.2_Missense_Mutation_p.K34R|BCS1L_uc010fvu.2_Missense_Mutation_p.K34R|BCS1L_uc010fvv.2_Missense_Mutation_p.K34R|BCS1L_uc002vir.2_Missense_Mutation_p.K34R|BCS1L_uc002vis.2_Missense_Mutation_p.K34R	NM_004328	NP_004319	Q9Y276	BCS1_HUMAN	BCS1-like	34	Mitochondrial matrix (Potential).				mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex III assembly|mitochondrial respiratory chain complex IV assembly	integral to membrane|mitochondrial respiratory chain complex III	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Renal(207;0.0474)		Epithelial(149;7.12e-07)|all cancers(144;0.000131)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGGCCCGGAAGGGTGTCCAA	0.582													26	59					0	0	0.00106085	0	0
CDK5R2	8941	broad.mit.edu	37	2	219825368	219825368	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:219825368G>A	uc002vjf.2	+	1	971	c.826G>A	c.(826-828)GAG>AAG	p.E276K		NM_003936	NP_003927	Q13319	CD5R2_HUMAN	cyclin-dependent kinase 5, regulatory subunit 2	276					regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase 5 holoenzyme complex	cyclin-dependent protein kinase 5 activator activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CATGGGCAACGAGATCTCCTA	0.677													41	68					0	0	0.00148497	0	0
SPEG	10290	broad.mit.edu	37	2	220348848	220348848	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:220348848A>C	uc010fwg.2	+	30	6663	c.6663A>C	c.(6661-6663)GAA>GAC	p.E2221D		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2221	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCAGGCCAGAACCAGTCCGAG	0.642													12	19					0	0	0.00185496	0	0
OBSL1	23363	broad.mit.edu	37	2	220431639	220431639	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:220431639G>A	uc010fwk.2	-	5	2104	c.2047C>T	c.(2047-2049)CTG>TTG	p.L683L	OBSL1_uc010fwl.1_Silent_p.L158L|OBSL1_uc002vmi.2_Silent_p.L683L|OBSL1_uc002vmj.2_Silent_p.L270L	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	683					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		ACGGCATGCAGGATGAGTCTG	0.622													19	26					0	0	0.00188189	0	0
COL4A3	1285	broad.mit.edu	37	2	228104886	228104886	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:228104886G>A	uc002vom.1	+	3	334	c.172G>A	c.(172-174)GGT>AGT	p.G58S	COL4A3_uc002von.1_Missense_Mutation_p.G58S|COL4A3_uc002voo.1_Missense_Mutation_p.G58S|COL4A3_uc002vop.1_Missense_Mutation_p.G58S|uc002voq.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	58	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		TGGACCCCCCGGTTCTCCTGG	0.522													6	13					0	0	0.000274275	0	0
COL4A3	1285	broad.mit.edu	37	2	228155586	228155586	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:228155586G>A	uc002vom.1	+	37	3356	c.3194G>A	c.(3193-3195)GGA>GAA	p.G1065E	COL4A3_uc002von.1_Missense_Mutation_p.G1065E|COL4A3_uc002voo.1_Missense_Mutation_p.G1065E|COL4A3_uc002vop.1_Missense_Mutation_p.G1065E|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1065	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		ACAAGGCCAGGACCACCGGGA	0.498													7	11					0	0	0.00198382	0	0
PID1	55022	broad.mit.edu	37	2	229890376	229890376	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:229890376G>A	uc002vpr.3	-	3	763	c.725C>T	c.(724-726)TCC>TTC	p.S242F	PID1_uc002vps.3_Missense_Mutation_p.S240F|PID1_uc002vpt.3_Missense_Mutation_p.S209F|PID1_uc002vpu.3_Missense_Mutation_p.S160F	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	242	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		CAATTCCTGGGAAACCTCTTC	0.512													22	57					0	0	0.000375601	0	0
PID1	55022	broad.mit.edu	37	2	229890452	229890452	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:229890452C>T	uc002vpr.3	-	3	687	c.649G>A	c.(649-651)GAG>AAG	p.E217K	PID1_uc002vps.3_Missense_Mutation_p.E215K|PID1_uc002vpt.3_Missense_Mutation_p.E184K|PID1_uc002vpu.3_Missense_Mutation_p.E135K	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	217	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		CTGAAGGCCTCCATCATGGCG	0.562													32	50					0	0	0.000491102	0	0
DNER	92737	broad.mit.edu	37	2	230411738	230411738	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:230411738G>A	uc002vpv.2	-	5	1065	c.918C>T	c.(916-918)ACC>ACT	p.T306T	DNER_uc010zly.1_Silent_p.T34T	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	306	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		CCGGCACACAGGTGCTGACCT	0.468													33	55					0	0	0.00209593	0	0
SLC16A14	151473	broad.mit.edu	37	2	230910666	230910666	+	Silent	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:230910666A>T	uc002vqd.1	-	4	1539	c.1176T>A	c.(1174-1176)CTT>CTA	p.L392L	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Silent_p.L392L|SLC16A14_uc002vqf.2_Silent_p.L392L	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	392	Helical; (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TACTGAGGACAAGGGTGAAGT	0.478													13	31					0	0	0.00185496	0	0
ALPP	250	broad.mit.edu	37	2	233244608	233244608	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:233244608G>A	uc002vsq.2	+	5	784	c.619G>A	c.(619-621)GAC>AAC	p.D207N	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	207						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GGGGTGCCAGGACATCGCTAC	0.682													13	39					0	0	0.00185496	0	0
EIF4E2	9470	broad.mit.edu	37	2	233422643	233422643	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:233422643T>A	uc002vta.2	+	3	263	c.185T>A	c.(184-186)TTT>TAT	p.F62Y	EIF4E2_uc002vtb.1_Missense_Mutation_p.F62Y|EIF4E2_uc002vsz.2_Missense_Mutation_p.F62Y|EIF4E2_uc010zmi.1_Intron	NM_004846	NP_004837	O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E	62					regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AACTACACTTTTTGGTACTCC	0.522													40	49					0	0	0.00170553	0	0
CXCR7	57007	broad.mit.edu	37	2	237489792	237489792	+	Silent	SNP	C	T	T	rs143420114		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:237489792C>T	uc010fyq.2	+	3	914	c.684C>T	c.(682-684)ATC>ATT	p.I228I	CXCR7_uc002vwd.2_Silent_p.I228I	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	228	Helical; Name=5; (Potential).			I -> V (in Ref. 8; AAH36661).	interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		TCTCCATTATCGCTGTCTTCT	0.577													28	40					0	0	0.00106085	0	0
RBM44	375316	broad.mit.edu	37	2	238726978	238726978	+	Silent	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:238726978T>G	uc002vxi.3	+	3	1551	c.1419T>G	c.(1417-1419)ACT>ACG	p.T473T		NM_001080504	NP_001073973	Q6ZP01	RBM44_HUMAN	RNA binding motif protein 44	472							nucleotide binding|RNA binding			ovary(4)	4		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;3.74e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.3e-11)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000118)|Lung(119;0.0112)|LUSC - Lung squamous cell carcinoma(224;0.0266)		ACGTTAGCACTGATTTTAGGG	0.378													25	50					0	0	0.000720815	0	0
ESPNL	339768	broad.mit.edu	37	2	239010659	239010659	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:239010659C>T	uc002vxq.3	+	2	482	c.372C>T	c.(370-372)CTC>CTT	p.L124L		NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	124	ANK 4.									pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		AGTGGCTGCTCCACGAGGGCC	0.692													4	10					0	0	0.00024832	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239234471	239234471	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:239234471T>A	uc002vye.2	+	3	333	c.214T>A	c.(214-216)TTC>ATC	p.F72I	TRAF3IP1_uc002vyf.2_Missense_Mutation_p.F72I	NM_015650	NP_056465	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting	72	Abolishes microtubules-binding when missing.					cytoplasm|cytoskeleton	protein binding			ovary(1)	1		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		AAAAATTAGCTTCCTACAAAA	0.418													10	28					0	0	0.000978159	0	0
CAPN10	11132	broad.mit.edu	37	2	241533346	241533346	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:241533346C>T	uc002vzk.1	+	5	896	c.712C>T	c.(712-714)CAT>TAT	p.H238Y	CAPN10_uc010zoh.1_Missense_Mutation_p.H238Y|CAPN10_uc002vzl.1_Missense_Mutation_p.H238Y|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Missense_Mutation_p.H110Y|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	238	Calpain catalytic.	By similarity.			actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		GGGGGAGTTCCATGCCTTCAT	0.657													55	102					0	0	0.000781405	0	0
PASK	23178	broad.mit.edu	37	2	242075323	242075323	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:242075323G>A	uc002wao.1	-	8	1361	c.1269C>T	c.(1267-1269)GAC>GAT	p.D423D	PASK_uc010zol.1_Silent_p.D237D|PASK_uc010zom.1_Silent_p.D388D|PASK_uc010fzl.1_Silent_p.D423D|PASK_uc010zon.1_Silent_p.D204D|PASK_uc002wap.2_5'Flank|PASK_uc002waq.2_Silent_p.D423D	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	423					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CCTGCCACGGGTCCAAGGTTC	0.627													38	52					0	0	0.00111076	0	0
C2orf85	285093	broad.mit.edu	37	2	242814229	242814229	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr2:242814229G>A	uc010fzu.1	+	2	545	c.522G>A	c.(520-522)ACG>ACA	p.T174T		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	174						integral to membrane				ovary(1)	1						TCCCCGCCACGGCCTGGGGTG	0.677													8	7					0	0	0.000978159	0	0
SIRPB2	284759	broad.mit.edu	37	20	1471926	1471926	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:1471926G>A	uc002wfg.2	-	1	308	c.80C>T	c.(79-81)CCC>CTC	p.P27L	SIRPB2_uc002wfh.3_Missense_Mutation_p.P27L|SIRPB2_uc010zpr.1_5'UTR	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	27						integral to membrane					0						CTTACCTGAGGGGACAAGGAC	0.617													12	20					0	0	0.00185496	0	0
FERMT1	55612	broad.mit.edu	37	20	6088199	6088199	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:6088199A>T	uc002wmr.2	-	6	1618	c.829T>A	c.(829-831)TTC>ATC	p.F277I	FERMT1_uc010gbt.2_Missense_Mutation_p.F20I|FERMT1_uc002wms.2_Missense_Mutation_p.F277I|FERMT1_uc002wmt.2_Missense_Mutation_p.F20I	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	277	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						AAGTCGAAGAAAGAATAATAT	0.368													11	20					0	0	0.000219431	0	0
HAO1	54363	broad.mit.edu	37	20	7866479	7866479	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:7866479C>T	uc002wmw.1	-	6	870	c.846G>A	c.(844-846)GTG>GTA	p.V282V	HAO1_uc010gbu.2_Silent_p.V282V	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	282	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						CCTTCCCTTCCACAGCCTCCA	0.483													41	64					0	0	0.000589545	0	0
SNAP25	6616	broad.mit.edu	37	20	10273890	10273890	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:10273890G>A	uc002wnq.1	+	5	457	c.245G>A	c.(244-246)GGA>GAA	p.G82E	SNAP25_uc002wnr.1_Intron|SNAP25_uc002wns.1_Missense_Mutation_p.G19E|SNAP25_uc010gca.1_Intron|SNAP25_uc010gcb.1_Missense_Mutation_p.G19E|SNAP25_uc010gcc.1_Intron	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	82					energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	ACGGACCTAGGAAAATTCTGC	0.458													31	51					0	0	0.001512	0	0
C20orf79	140856	broad.mit.edu	37	20	18794514	18794514	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:18794514G>A	uc002wrk.2	+	1	145	c.55G>A	c.(55-57)GTG>ATG	p.V19M	uc002wrj.1_Intron	NM_178483	NP_848578	Q9UJQ7	CT079_HUMAN	hypothetical protein LOC140856	19							sterol binding			skin(3)	3						TGGACCTCTGGTGGGCCAGTT	0.517													15	29					0	0	0.000422831	0	0
SLC24A3	57419	broad.mit.edu	37	20	19664827	19664827	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:19664827C>T	uc002wrl.2	+	11	1106	c.909C>T	c.(907-909)TTC>TTT	p.F303F		NM_020689	NP_065740	Q9HC58	NCKX3_HUMAN	solute carrier family 24	303	Cytoplasmic (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(1)	1						TAGCAAATTTCCACCGCAAAG	0.468													27	57					0	0	0.00178596	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20484026	20484026	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:20484026G>A	uc002wrz.2	-	35	5320	c.5177C>T	c.(5176-5178)CCG>CTG	p.P1726L	RALGAPA2_uc010gcx.2_Missense_Mutation_p.P1430L|RALGAPA2_uc010zsg.1_Missense_Mutation_p.P1174L|RALGAPA2_uc002wsa.1_Missense_Mutation_p.P498L	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1726	Rap-GAP.				activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGAGTCTGACGGCATTCGAGT	0.537													20	45					0	0	0.00229938	0	0
C20orf3	57136	broad.mit.edu	37	20	24959505	24959506	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:24959505_24959506GG>AA	uc002wty.2	-	3	326_327	c.225_226CC>TT	c.(223-228)CCCCCG>CCTTCG	p.P76S	C20orf3_uc002wtz.2_Missense_Mutation_p.P76S|C20orf3_uc010zsw.1_Missense_Mutation_p.P76S	NM_020531	NP_065392	Q9HDC9	APMAP_HUMAN	chromosome 20 open reading frame 3	76	Extracellular (Potential).				biosynthetic process	cell surface|integral to membrane	arylesterase activity|strictosidine synthase activity			ovary(1)	1						AGCAAGAGCGGGGGTTCTTTGA	0.436													25	33					0	0	6.4e-05	0	0
ACSS1	84532	broad.mit.edu	37	20	25000673	25000673	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:25000673G>A	uc002wub.2	-	7	2097	c.1219C>T	c.(1219-1221)CGC>TGC	p.R407C	ACSS1_uc002wuc.2_Missense_Mutation_p.R407C|ACSS1_uc010gdc.2_Intron|ACSS1_uc002wud.1_RNA|ACSS1_uc002wua.2_Missense_Mutation_p.R324C	NM_032501	NP_115890	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	407					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			ovary(1)|skin(1)	2					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGGGAGGAGCGATCATACTTC	0.587													29	52					0	0	0.001512	0	0
DEFB118	117285	broad.mit.edu	37	20	29960918	29960918	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:29960918C>T	uc002wvr.2	+	2	343	c.317C>T	c.(316-318)TCT>TTT	p.S106F		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	106					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GTTGAAGAGTCTGAGGCGGGA	0.438													16	34					0	0	0.00074312	0	0
RBL1	5933	broad.mit.edu	37	20	35668583	35668583	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:35668583G>A	uc002xgi.2	-	14	1955	c.1876C>T	c.(1876-1878)CGA>TGA	p.R626*	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Nonsense_Mutation_p.R626*	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	626	Pocket; binds T and E1A.|Spacer.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				CTGTCAGTTCGAACTTCCTTG	0.413													39	65					0	0	0.000509022	0	0
SLC32A1	140679	broad.mit.edu	37	20	37356590	37356590	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:37356590A>G	uc002xjc.2	+	2	1149	c.886A>G	c.(886-888)AAG>GAG	p.K296E		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	296	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GGCCTGGGAGAAGGTCAAGTT	0.547													23	35					0	0	0.00047179	0	0
PTPRT	11122	broad.mit.edu	37	20	40790000	40790000	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:40790000C>T	uc002xkg.2	-	17	2858	c.2674G>A	c.(2674-2676)GAA>AAA	p.E892K	PTPRT_uc010ggj.2_Missense_Mutation_p.E911K|PTPRT_uc010ggi.2_Missense_Mutation_p.E95K	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	892	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ACCTCGTATTCCTCCTTGAAC	0.478													21	37					0	0	0.00229938	0	0
SERINC3	10955	broad.mit.edu	37	20	43129877	43129877	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:43129877G>A	uc002xme.2	-	9	1254	c.1120C>T	c.(1120-1122)CTT>TTT	p.L374F	SERINC3_uc002xmf.1_Missense_Mutation_p.L374F|SERINC3_uc010ggs.1_Missense_Mutation_p.L367F|SERINC3_uc010zwp.1_Missense_Mutation_p.L319F	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	374	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			GTATCACCAAGGATGACGCTG	0.512													31	49					0	0	0.00058488	0	0
SLC35C2	51006	broad.mit.edu	37	20	44987131	44987131	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:44987131G>A	uc002xro.2	-	2	556	c.15C>T	c.(13-15)GCC>GCT	p.A5A	SLC35C2_uc002xrp.2_Silent_p.A5A|SLC35C2_uc002xrq.2_Silent_p.A5A|SLC35C2_uc002xrr.2_Silent_p.A5A|SLC35C2_uc010zxn.1_5'UTR|SLC35C2_uc010zxo.1_5'UTR|SLC35C2_uc010zxp.1_Silent_p.A34A	NM_173179	NP_775271	Q9NQQ7	S35C2_HUMAN	solute carrier family 35, member C2 isoform a	5					transport	integral to membrane				ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCACATCGAGGGCCCACCTCC	0.597													12	29					0	0	0.00185496	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887289	47887289	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:47887289G>A	uc002xui.2	-	3	1307	c.1060C>T	c.(1060-1062)CGC>TGC	p.R354C		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	354							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			ATATTGGGGCGAAGGAAGGGC	0.502													46	97					0	0	0.000781405	0	0
ATP9A	10079	broad.mit.edu	37	20	50230311	50230311	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:50230311G>A	uc002xwg.1	-	23	2476	c.2476C>T	c.(2476-2478)CGG>TGG	p.R826W	ATP9A_uc010gih.1_Missense_Mutation_p.R690W|ATP9A_uc002xwf.1_5'UTR	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	826	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						ATAAGCAACCGGCCAAGATGC	0.502													75	113					0	0	0.000781405	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871554	51871554	+	Silent	SNP	T	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:51871554T>G	uc002xwo.2	+	2	2513	c.1557T>G	c.(1555-1557)TCT>TCG	p.S519S		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	519					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TTTTGAAATCTTTGGAAAATA	0.493													24	38					0	0	0.000586117	0	0
CASS4	57091	broad.mit.edu	37	20	55026928	55026928	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:55026928C>T	uc002xxp.2	+	6	921	c.696C>T	c.(694-696)AGC>AGT	p.S232S	CASS4_uc002xxq.3_Silent_p.S232S|CASS4_uc002xxr.2_Silent_p.S232S|CASS4_uc010zze.1_Silent_p.S178S|CASS4_uc010gio.2_Intron	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	232					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						GCGGTTACAGCACATTACCAA	0.502													15	27					0	0	0.000219431	0	0
GNAS	2778	broad.mit.edu	37	20	57428697	57428697	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:57428697G>A	uc002xzw.2	+	1	662	c.377G>A	c.(376-378)GGG>GAG	p.G126E	GNASAS_uc002xzs.1_5'Flank|GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TTCCCCAGTGGGGTCCATGCA	0.632			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			9	28					0	0	0.000673444	0	0
TUBB1	81027	broad.mit.edu	37	20	57599799	57599799	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:57599799G>A	uc002yak.2	+	4	1586	c.1317G>A	c.(1315-1317)ACG>ACA	p.T439T		NM_030773	NP_110400	Q9H4B7	TBB1_HUMAN	beta tubulin 1, class VI	439					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity			ovary(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)		Colchicine(DB01394)|Docetaxel(DB01248)|Paclitaxel(DB01229)|Vindesine(DB00309)	AAGAGGTCACGGAGGAGGCAG	0.443													6	31					0	0	0.00198382	0	0
ZNF831	128611	broad.mit.edu	37	20	57829535	57829535	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:57829535C>T	uc002yan.2	+	5	4771	c.4771C>T	c.(4771-4773)CCT>TCT	p.P1591S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1591						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GACGTTTTTTCCTTCCAGAGG	0.478													38	45					0	0	0.00111076	0	0
SYCP2	10388	broad.mit.edu	37	20	58475306	58475306	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr20:58475306C>T	uc002yaz.2	-	17	1430	c.1291G>A	c.(1291-1293)GGA>AGA	p.G431R	SYCP2_uc010gju.1_Missense_Mutation_p.G332R	NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	431					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AGCTCTTCTCCGACTGGTGAG	0.333													13	22					0	0	0.000219431	0	0
TPTE	7179	broad.mit.edu	37	21	10914373	10914373	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:10914373C>T	uc002yip.1	-	21	1714	c.1346G>A	c.(1345-1347)GGA>GAA	p.G449E	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.G431E|TPTE_uc002yir.1_Missense_Mutation_p.G411E|TPTE_uc010gkv.1_Missense_Mutation_p.G311E	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	449	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CGAACATTTTCCTAATGAAAT	0.318													8	68					0	0	0.000673444	0	0
TPTE	7179	broad.mit.edu	37	21	10914379	10914379	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:10914379G>A	uc002yip.1	-	21	1708	c.1340C>T	c.(1339-1341)TCA>TTA	p.S447L	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.S429L|TPTE_uc002yir.1_Missense_Mutation_p.S409L|TPTE_uc010gkv.1_Missense_Mutation_p.S309L	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	447	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTTCCTAATGAAATAGTGGA	0.328													10	65					0	0	0.00185496	0	0
TPTE	7179	broad.mit.edu	37	21	10973727	10973727	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:10973727C>T	uc002yip.1	-	4	375	c.7G>A	c.(7-9)GAA>AAA	p.E3K	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.E3K|TPTE_uc002yir.1_Missense_Mutation_p.E3K|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	3					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTCACCTTTCATTCATACGT	0.348													20	77					0	0	0.00152264	0	0
C21orf81	391267	broad.mit.edu	37	21	15352093	15352093	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:15352093C>T	uc002yji.2	-	1		c.673G>A			C21orf81_uc002yjj.3_RNA	NR_027270				Homo sapiens C21orf81 protein (C21orf81) mRNA, complete cds.												0						TCCGCGGCGTCGCCCTTGACA	0.667													14	15					0	0	0.000422831	0	0
LIPI	149998	broad.mit.edu	37	21	15561499	15561499	+	Silent	SNP	G	A	A	rs148528170	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:15561499G>A	uc002yjm.2	-	2	361	c.351C>T	c.(349-351)TTC>TTT	p.F117F	LIPI_uc010gkw.1_Silent_p.F50F	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	96					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		AAATCCTTACGAAGTTCTGAA	0.368													26	50					0	0	0.00127121	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28338411	28338411	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:28338411C>T	uc002ymg.2	-	1	1029	c.300G>A	c.(298-300)TTG>TTA	p.L100L		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	100					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GCTCCAGGTCCAAGAGGAACC	0.682													16	32					0	0	0.00074312	0	0
USP16	10600	broad.mit.edu	37	21	30419289	30419289	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:30419289C>T	uc002ymy.2	+	14	1860	c.1658C>T	c.(1657-1659)CCC>CTC	p.P553L	USP16_uc002ymx.2_Missense_Mutation_p.P552L|USP16_uc002ymw.2_Missense_Mutation_p.P553L|USP16_uc011acm.1_Missense_Mutation_p.P538L|USP16_uc011acn.1_Missense_Mutation_p.P219L|USP16_uc011aco.1_Missense_Mutation_p.P243L	NM_006447	NP_006438	Q9Y5T5	UBP16_HUMAN	ubiquitin specific protease 16 isoform a	553					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4						ACATCTTCTCCCACTAGGAAT	0.363													22	30					0	0	0.00188189	0	0
GRIK1	2897	broad.mit.edu	37	21	30949456	30949456	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:30949456C>T	uc002yno.1	-	14	2422	c.1958G>A	c.(1957-1959)GGG>GAG	p.G653E	GRIK1_uc002ynn.2_Missense_Mutation_p.G638E|GRIK1_uc011acs.1_Missense_Mutation_p.G653E|GRIK1_uc011act.1_Missense_Mutation_p.G514E	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	653	Cytoplasmic (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCACCATATCCCTCCAACTAT	0.463													23	64					0	0	0.00047179	0	0
RCAN1	1827	broad.mit.edu	37	21	35893825	35893825	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:35893825G>A	uc002yue.2	-	3	630	c.558C>T	c.(556-558)CTC>CTT	p.L186L	RCAN1_uc002yuc.2_Silent_p.L105L|RCAN1_uc002yud.2_Silent_p.L51L|RCAN1_uc002yub.2_Silent_p.L131L|RCAN1_uc011adx.1_Silent_p.L131L	NM_004414	NP_004405	P53805	RCAN1_HUMAN	calcipressin 1 isoform a	186					blood circulation|calcium-mediated signaling|central nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						TGGCATATAAGAGATCATAGT	0.597													159	228					0	0	0.000781405	0	0
TTC3	7267	broad.mit.edu	37	21	38538400	38538400	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:38538400C>T	uc002yvz.2	+	33	3989	c.3884C>T	c.(3883-3885)TCC>TTC	p.S1295F	TTC3_uc011aee.1_Missense_Mutation_p.S985F|TTC3_uc002ywa.2_Missense_Mutation_p.S1295F|TTC3_uc002ywb.2_Missense_Mutation_p.S1295F|TTC3_uc010gnf.2_Missense_Mutation_p.S1060F|TTC3_uc002ywc.2_Missense_Mutation_p.S985F|TTC3_uc002ywd.1_Missense_Mutation_p.S359F	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1295					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TCCTGTAATTCCCCCAAACCG	0.448													36	66					0	0	0.000953801	0	0
DSCAM	1826	broad.mit.edu	37	21	41719788	41719788	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:41719788G>A	uc002yyq.1	-	6	1471	c.1019C>T	c.(1018-1020)ACT>ATT	p.T340I	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	340	Extracellular (Potential).|Ig-like C2-type 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTGGTCCTCAGTTCCTGTCAC	0.488													33	55					0	0	0.00178596	0	0
DSCAM	1826	broad.mit.edu	37	21	42080671	42080671	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:42080671G>A	uc002yyq.1	-	2	522	c.70C>T	c.(70-72)CTC>TTC	p.L24F	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	24	Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ACAAAGTAGAGGCTGGAGTGT	0.517													33	65					0	0	0.000692331	0	0
FAM3B	54097	broad.mit.edu	37	21	42710382	42710382	+	Missense_Mutation	SNP	G	A	A	rs146229700		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:42710382G>A	uc002yzb.1	+	3	387	c.241G>A	c.(241-243)GGA>AGA	p.G81R	FAM3B_uc002yza.2_RNA|FAM3B_uc002yzc.1_Missense_Mutation_p.G33R|FAM3B_uc002yzd.1_Missense_Mutation_p.G104R|FAM3B_uc011aeq.1_Missense_Mutation_p.G95R	NM_058186	NP_478066	P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	81					apoptosis|insulin secretion	extracellular space	cytokine activity				0		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				GTTACTCAGCGGAGGTGGCAG	0.458													19	49					0	0	0.000958276	0	0
C21orf29	54084	broad.mit.edu	37	21	45929219	45929219	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:45929219G>A	uc002zfe.1	-	10	1683	c.1617C>T	c.(1615-1617)TTC>TTT	p.F539F	C21orf29_uc010gpv.1_Silent_p.F471F	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	539	EAR 5.				cell adhesion	extracellular region	structural molecule activity				0						CCACAGCGAGGAAGATCCTCT	0.507													4	9					0	0	0.00024832	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047570	46047570	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr21:46047570C>T	uc002zfp.3	+	1	531	c.482C>T	c.(481-483)TCA>TTA	p.S161L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198690	NP_941963	P60411	KR109_HUMAN	keratin associated protein 10-9	161	25 X 5 AA repeats of C-C-X(3).					keratin filament					0						GATTCCTATTCATGCTGCCAA	0.418													46	112					0	0	0.000781405	0	0
CECR2	27443	broad.mit.edu	37	22	18028326	18028326	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:18028326C>T	uc010gqw.1	+	16	3409	c.3283C>T	c.(3283-3285)CCC>TCC	p.P1095S	CECR2_uc010gqv.1_Missense_Mutation_p.P953S|CECR2_uc002zml.2_Missense_Mutation_p.P954S|CECR2_uc002zmo.2_RNA	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1137					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GAGCCAGTTTCCCCCGCTGTA	0.607													10	2					0	0	0.000673444	0	0
ADRBK2	157	broad.mit.edu	37	22	26118328	26118328	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:26118328C>T	uc003abx.3	+	21	2125	c.1978C>T	c.(1978-1980)CGT>TGT	p.R660C	ADRBK2_uc003aby.3_RNA	NM_005160	NP_005151	P35626	ARBK2_HUMAN	beta-adrenergic receptor kinase 2	660							ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			lung(3)|ovary(2)|stomach(1)|central_nervous_system(1)	7					Adenosine triphosphate(DB00171)	GCTATTGCGTCGTGCCCCGAA	0.542													57	10					0	0	0.000781405	0	0
RFPL2	10739	broad.mit.edu	37	22	32589013	32589013	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:32589013C>T	uc003amg.3	-	4	1368	c.432G>A	c.(430-432)ATG>ATA	p.M144I	RFPL2_uc003ame.3_Missense_Mutation_p.M83I|RFPL2_uc003amf.3_Missense_Mutation_p.M54I|RFPL2_uc003amh.3_Missense_Mutation_p.M54I	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	144							zinc ion binding			skin(1)	1						TCCGAGAGACCATGGAAGAGC	0.527													13	50					0	0	0.000958276	0	0
HMGXB4	10042	broad.mit.edu	37	22	35660647	35660647	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:35660647C>T	uc003anl.2	+	5	440	c.266C>T	c.(265-267)TCG>TTG	p.S89L	HMGXB4_uc011amh.1_5'UTR|HMGXB4_uc003ank.2_5'UTR	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1	89					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						CTAGATATTTCGTCTTTGGAA	0.403													113	32					0	0	0.000781405	0	0
SGSM3	27352	broad.mit.edu	37	22	40803434	40803434	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:40803434T>A	uc003ayu.1	+	13	1595	c.1386T>A	c.(1384-1386)TAT>TAA	p.Y462*	SGSM3_uc011aos.1_Nonsense_Mutation_p.Y395*|SGSM3_uc011aot.1_Nonsense_Mutation_p.Y399*|SGSM3_uc010gyd.1_Nonsense_Mutation_p.Y533*	NM_015705	NP_056520	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	462					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			ovary(2)	2						CTCCAGACTATAGCATGGAGA	0.642													15	11					0	0	0.000308642	0	0
A4GALT	53947	broad.mit.edu	37	22	43089095	43089095	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:43089095G>A	uc003bdb.2	-	3	1124	c.863C>T	c.(862-864)CCC>CTC	p.P288L	A4GALT_uc010gzd.2_Missense_Mutation_p.P288L	NM_017436	NP_059132	Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	288	Lumenal (Potential).				glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			central_nervous_system(2)	2						GTCCTGCCAGGGGATGGGGTA	0.637													8	5					0	0	0.000673444	0	0
EFCAB6	64800	broad.mit.edu	37	22	43933267	43933268	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:43933267_43933268GG>AA	uc003bdy.1	-	29	4252_4253	c.4037_4038CC>TT	c.(4036-4038)TCC>TTT	p.S1346F	EFCAB6_uc003bdz.1_Missense_Mutation_p.S1194F|EFCAB6_uc010gzi.1_Missense_Mutation_p.S1194F	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1346	Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				CCAGGAAATCGGAGGCGTTGAT	0.569													75	29					0	0	6.4e-05	0	0
KIAA1644	85352	broad.mit.edu	37	22	44692610	44692610	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:44692610C>T	uc003bet.2	-	3	356	c.223G>A	c.(223-225)GAG>AAG	p.E75K		NM_001099294	NP_001092764	Q3SXP7	K1644_HUMAN	hypothetical protein LOC85352 precursor	75	Extracellular (Potential).					integral to membrane				ovary(1)	1		all_neural(38;0.0762)|Ovarian(80;0.105)|Glioma(61;0.222)				GCCTGGAACTCCGTCTCGTTG	0.592													134	34					0	0	0.000781405	0	0
WNT7B	7477	broad.mit.edu	37	22	46327142	46327142	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr22:46327142C>T	uc003bgo.2	-	3	780	c.406G>A	c.(406-408)GAG>AAG	p.E136K	WNT7B_uc010haa.2_Missense_Mutation_p.E140K	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	136					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		CCCTGCTTCTCGCGGTCGCAG	0.682													38	12					0	0	0.00195071	0	0
C3orf31	132001	broad.mit.edu	37	3	11885596	11885596	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:11885596G>A	uc003bwh.2	-	2	467	c.225C>T	c.(223-225)TTC>TTT	p.F75F	C3orf31_uc003bwj.2_Silent_p.F75F|C3orf31_uc003bwi.2_RNA|C3orf31_uc011auo.1_Silent_p.F75F|C3orf31_uc011aup.1_RNA|C3orf31_uc010hdy.1_RNA	NM_138807	NP_620162	Q96BW9	MMP37_HUMAN	MMP37-like protein, mitochondrial precursor	75					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane					0						AAACTTTTAGGAAAGAGTAGT	0.418													15	9					0	0	0.000566183	0	0
Unknown	0	broad.mit.edu	37	3	12299480	12299480	+	RNA	SNP	G	A	A	rs3211205	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:12299480G>A	uc003bwp.1	-	1		c.473C>T				NR_003112				NR_003112																		CATAGGCAAGGAAATCCACAT	0.483													7	5					0	0	0.00198382	0	0
GRIP2	80852	broad.mit.edu	37	3	14547163	14547163	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:14547163G>A	uc011avi.1	-	21	2827	c.2827C>T	c.(2827-2829)CCA>TCA	p.P943S	GRIP2_uc010heh.2_RNA|GRIP2_uc011avh.1_Missense_Mutation_p.P474S	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	845					synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						TCCTCCTCTGGAAAGCTCTCG	0.677													3	0					0	0	0.00024832	0	0
RFTN1	23180	broad.mit.edu	37	3	16411787	16411787	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:16411787C>T	uc003cay.2	-	6	1109	c.827_splice	c.e6-1	p.K276_splice	RFTN1_uc010hes.2_Splice_Site_p.K240_splice	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein							plasma membrane				ovary(3)|central_nervous_system(1)	4						ATCTCCATTTCTGTTGGGATT	0.448													73	45					0	0	0.000781405	0	0
NGLY1	55768	broad.mit.edu	37	3	25781072	25781072	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:25781072G>A	uc003cdl.2	-	5	985	c.877C>T	c.(877-879)CCA>TCA	p.P293S	NGLY1_uc010hfg.2_Missense_Mutation_p.P293S|NGLY1_uc003cdm.2_Missense_Mutation_p.P293S|NGLY1_uc011awo.1_Missense_Mutation_p.P251S|NGLY1_uc003cdk.2_Intron	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	293					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						ACCCACCTTGGGAATCGATTG	0.378													26	52					0	0	0.000586117	0	0
NEK10	152110	broad.mit.edu	37	3	27387625	27387625	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:27387625C>G	uc003cdt.1	-	5	489	c.215G>C	c.(214-216)CGG>CCG	p.R72P		NM_199347	NP_955379	Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10 isoform 3	72							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						CCACTGACCCCGAGCTCTGTG	0.468													3	78					0	0	0.00024832	0	0
TRANK1	9881	broad.mit.edu	37	3	36872412	36872412	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:36872412C>T	uc003cgj.2	-	12	7182	c.6880G>A	c.(6880-6882)GTT>ATT	p.V2294I		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2844					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						ATATCCGAAACCCTCTTGATG	0.602													34	48					0	0	0.00209593	0	0
TRANK1	9881	broad.mit.edu	37	3	36899226	36899226	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:36899226G>A	uc003cgj.2	-	3	507	c.205C>T	c.(205-207)CAC>TAC	p.H69Y		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	619					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TTCCCCAGGTGGGCAGCAGAG	0.567													39	75					0	0	0.00128727	0	0
SCN10A	6336	broad.mit.edu	37	3	38793755	38793755	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:38793755T>C	uc003ciq.2	-	11	1710	c.1710A>G	c.(1708-1710)CAA>CAG	p.Q570Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	570					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGGGCGGCGGTTGGTGTTCAT	0.597													36	70					0	0	0.00148497	0	0
XIRP1	165904	broad.mit.edu	37	3	39225664	39225664	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:39225664C>T	uc003cjk.1	-	2	5494	c.5273G>A	c.(5272-5274)AGC>AAC	p.S1758N	XIRP1_uc003cji.2_3'UTR|XIRP1_uc003cjj.2_Missense_Mutation_p.S441N	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1758	Interaction with FLNC.						actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTGTTGTGAGCTCCCTGGCCC	0.577													62	79					0	0	0.000781405	0	0
ZNF662	389114	broad.mit.edu	37	3	42956297	42956297	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:42956297G>A	uc003cmi.2	+	5	1084	c.732G>A	c.(730-732)GGG>GGA	p.G244G	ZNF662_uc003cmk.2_Silent_p.G270G|ZNF662_uc003cmj.2_Silent_p.G136G	NM_207404	NP_997287	Q6ZS27	ZN662_HUMAN	zinc finger protein 662 isoform 1	244					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TTCACAGTGGGGTGAAACCCT	0.413													28	31					0	0	0.00106085	0	0
ZNF502	91392	broad.mit.edu	37	3	44763909	44763909	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:44763909C>T	uc011baa.1	+	4	1855	c.1600C>T	c.(1600-1602)CTT>TTT	p.L534F	ZNF502_uc003cns.2_Missense_Mutation_p.L534F|ZNF502_uc011bab.1_Missense_Mutation_p.L534F|ZNF502_uc003cnt.2_Missense_Mutation_p.L534F	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	534	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TAGTTCAGTCCTTTTCAGACA	0.428													24	46					0	0	0.000878237	0	0
SACM1L	22908	broad.mit.edu	37	3	45748372	45748372	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:45748372G>A	uc003cos.2	+	4	510	c.306G>A	c.(304-306)AAG>AAA	p.K102K	SACM1L_uc011bag.1_5'UTR|SACM1L_uc011bah.1_Intron	NM_014016	NP_054735	Q9NTJ5	SAC1_HUMAN	suppressor of actin 1	102						Golgi apparatus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0102)|KIRC - Kidney renal clear cell carcinoma(197;0.0234)|Kidney(197;0.0277)		CTTATAAGAAGACAATGTTGC	0.378													27	24					0	0	0.000720815	0	0
CCR3	1232	broad.mit.edu	37	3	46307148	46307149	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:46307148_46307149CC>TT	uc003cpg.1	+	4	1042_1043	c.499_500CC>TT	c.(499-501)CCT>TTT	p.P167F	CCR3_uc003cpi.1_Missense_Mutation_p.P167F|CCR3_uc003cpj.1_Missense_Mutation_p.P167F|CCR3_uc003cpk.1_Missense_Mutation_p.P188F|CCR3_uc010hjb.1_Missense_Mutation_p.P185F|CCR3_uc003cpl.1_Missense_Mutation_p.P200F	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	167	Helical; Name=4; (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		AGCAGCTCTTCCTGAATTTATC	0.495													29	45					0	0	6.4e-05	0	0
CCR2	729230	broad.mit.edu	37	3	46399601	46399601	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:46399601C>T	uc003cpn.3	+	2	1068	c.583C>T	c.(583-585)CCA>TCA	p.P195S	CCR2_uc003cpm.3_Missense_Mutation_p.P195S	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	195	Extracellular (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		CCCTTATTTTCCACGAGGATG	0.453													134	211					0	0	0.000781405	0	0
COL7A1	1294	broad.mit.edu	37	3	48624701	48624701	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:48624701C>T	uc003ctz.2	-	23	3062	c.3061G>A	c.(3061-3063)GGC>AGC	p.G1021S		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1021	Nonhelical region (NC1).|Fibronectin type-III 9.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TAAGAGACGCCAGGCTCTAGC	0.577													11	10					0	0	0.000673444	0	0
CELSR3	1951	broad.mit.edu	37	3	48691417	48691417	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:48691417G>A	uc003cul.2	-	8	5453	c.5172C>T	c.(5170-5172)CAC>CAT	p.H1724H	CELSR3_uc003cuf.1_Silent_p.H1794H|CELSR3_uc010hkg.2_5'Flank	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	1724	Extracellular (Potential).|EGF-like 4; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGTCACAAAAGTGTAGCTTGG	0.597													14	22					0	0	0.00185496	0	0
WDR6	11180	broad.mit.edu	37	3	49051357	49051357	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:49051357G>A	uc003cvj.2	+	2	2618	c.2480G>A	c.(2479-2481)GGC>GAC	p.G827D	WDR6_uc011bbx.1_3'UTR|WDR6_uc011bby.1_Missense_Mutation_p.G275D|WDR6_uc010hkn.2_Missense_Mutation_p.G771D|WDR6_uc011bbz.1_Missense_Mutation_p.G746D	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	797					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CCTCAGCCAGGCCTGACTGCC	0.642											OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	25					0	0	0.000219431	0	0
SEMA3F	6405	broad.mit.edu	37	3	50223737	50223737	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:50223737G>A	uc003cyj.2	+	17	1967	c.1769G>A	c.(1768-1770)CGG>CAG	p.R590Q	SEMA3F_uc003cyk.2_Missense_Mutation_p.R559Q	NM_004186	NP_004177	Q13275	SEM3F_HUMAN	semaphorin 3F precursor	590					axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			lung(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		CAGGACGTCCGGCACGGAAAC	0.637													15	17					0	0	0.00121646	0	0
GNAI2	2771	broad.mit.edu	37	3	50294242	50294242	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:50294242C>T	uc003cyq.1	+	6	802	c.681C>T	c.(679-681)GCC>GCT	p.A227A	GNAI2_uc003cyo.1_Silent_p.A211A|GNAI2_uc003cyp.1_Silent_p.A211A|GNAI2_uc010hlg.1_Silent_p.A146A|GNAI2_uc011bdn.1_Silent_p.A190A|GNAI2_uc003cyr.1_Silent_p.A146A	NM_002070	NP_002061	P04899	GNAI2_HUMAN	guanine nucleotide binding protein (G protein),	227					adenosine receptor signaling pathway|cell cycle|cell division|gamma-aminobutyric acid signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|platelet activation|response to nutrient|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000288)|KIRC - Kidney renal clear cell carcinoma(197;0.00571)|Kidney(197;0.00651)		TCTGCGTAGCCTTGAGCGCCT	0.572													30	32					0	0	0.001512	0	0
CACNA2D2	9254	broad.mit.edu	37	3	50416522	50416522	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:50416522C>T	uc003daq.2	-	12	1298	c.1260_splice	c.e12+1	p.T420_splice	CACNA2D2_uc003dap.2_Splice_Site_p.T420_splice	NM_006030	NP_006021	Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha						energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	TTGAGCCTCACCGTCCGGTTT	0.592													13	16					0	0	0.000219431	0	0
DOCK3	1795	broad.mit.edu	37	3	51297745	51297745	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:51297745C>T	uc011bds.1	+	23	2366	c.2343C>T	c.(2341-2343)CTC>CTT	p.L781L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	781						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGAAACACTCCTTTTTACTC	0.468													7	17					0	0	0.000442599	0	0
DOCK3	1795	broad.mit.edu	37	3	51370667	51370667	+	Silent	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:51370667A>G	uc011bds.1	+	35	3617	c.3594A>G	c.(3592-3594)GAA>GAG	p.E1198E		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1198	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCCTCATGGAACGTCTTCTTG	0.542													25	63					0	0	0.00209593	0	0
ALAS1	211	broad.mit.edu	37	3	52248117	52248117	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:52248117C>T	uc003dcy.1	+	12	2181	c.1844C>T	c.(1843-1845)CCA>CTA	p.P615L	ALAS1_uc003dcz.1_Missense_Mutation_p.P615L|ALAS1_uc011bec.1_Missense_Mutation_p.P632L	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	615					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGCAGGAGGCCACTGCATTTT	0.468													29	53					0	0	0.001512	0	0
TLR9	54106	broad.mit.edu	37	3	52255454	52255454	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:52255454C>T	uc003dda.1	-	2	3512	c.2878G>A	c.(2878-2880)GAG>AAG	p.E960K	TLR9_uc003ddb.2_Missense_Mutation_p.E1057K	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	960	TIR.|Cytoplasmic (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	TTGCGGTCCTCCAGCAGGCGC	0.692													13	20					0	0	0.00136819	0	0
DNAH1	25981	broad.mit.edu	37	3	52426985	52426985	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:52426985C>T	uc011bef.1	+	65	10679	c.10418C>T	c.(10417-10419)TCC>TTC	p.S3473F	DNAH1_uc003ddv.2_Missense_Mutation_p.S331F	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3538					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TACCAGTACTCCCTTGAGTGG	0.582													40	66					0	0	0.000680045	0	0
PHF7	51533	broad.mit.edu	37	3	52457136	52457136	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:52457136C>T	uc003ddy.2	+	11	1755	c.949C>T	c.(949-951)CCT>TCT	p.P317S	PHF7_uc003ddz.2_Missense_Mutation_p.P278S	NM_016483	NP_057567	Q9BWX1	PHF7_HUMAN	PHD finger protein 7 isoform 1	317						nucleus	zinc ion binding			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		AGGGGACATCCCTTGCTGCAG	0.527													26	60					0	0	0.00106085	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54676196	54676196	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:54676196C>T	uc003dhf.2	+	11	1143	c.1095C>T	c.(1093-1095)ATC>ATT	p.I365I	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Silent_p.I271I|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Silent_p.I99I|HESRG_uc003dhj.2_5'Flank	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	365	Extracellular (Potential).|VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GTCAGGCCATCATGCTCATAA	0.428													16	8					0	0	0.00121646	0	0
SLMAP	7871	broad.mit.edu	37	3	57843838	57843838	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:57843838C>T	uc003dje.1	+	7	844	c.639C>T	c.(637-639)CTC>CTT	p.L213L	SLMAP_uc003djc.1_Silent_p.L213L|SLMAP_uc003djd.1_Silent_p.L213L|SLMAP_uc003djf.1_Silent_p.L213L	NM_007159	NP_009090	Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	213	Cytoplasmic (Potential).				muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding				0				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		AAGATAGACTCTTATCACGGT	0.303													64	36					0	0	0.000781405	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64587690	64587690	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:64587690G>A	uc003dmg.2	-	26	3979	c.3947C>T	c.(3946-3948)CCC>CTC	p.P1316L	ADAMTS9_uc011bfo.1_Missense_Mutation_p.P1288L|ADAMTS9_uc003dmh.1_Missense_Mutation_p.P1145L|ADAMTS9_uc011bfp.1_Missense_Mutation_p.P227L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1316					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GGCGCTCCGGGGACGATAGTC	0.577													96	65					0	0	0.000781405	0	0
GBE1	2632	broad.mit.edu	37	3	81698054	81698054	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:81698054G>A	uc003dqg.2	-	6	927	c.644C>T	c.(643-645)TCT>TTT	p.S215F	GBE1_uc011bgm.1_Missense_Mutation_p.S174F	NM_000158	NP_000149	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	215					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(3)	3		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		ATGTTTATAAGAAGCTACTTT	0.328									Glycogen_Storage_Disease_type_IV				7	26					0	0	0.00198382	0	0
CADM2	253559	broad.mit.edu	37	3	86115815	86115815	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:86115815G>A	uc003dqj.2	+	10	1816	c.1190G>A	c.(1189-1191)GGA>GAA	p.G397E	CADM2_uc003dqk.2_Missense_Mutation_p.G366E|CADM2_uc003dql.2_Missense_Mutation_p.G399E|uc003dqm.1_5'Flank	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	397	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ATATATGCAGGAACGTATTTA	0.373													22	32					0	0	0.000375601	0	0
EPHA3	2042	broad.mit.edu	37	3	89521711	89521711	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:89521711G>A	uc003dqy.2	+	16	3013	c.2788G>A	c.(2788-2790)GAA>AAA	p.E930K	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	930	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		ACACTGCAAGGAAATCTTCAC	0.423										TSP Lung(6;0.00050)			27	47					0	0	0.000878237	0	0
EPHA6	285220	broad.mit.edu	37	3	96706601	96706601	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:96706601C>T	uc010how.1	+	3	921	c.878C>T	c.(877-879)TCA>TTA	p.S293L	EPHA6_uc003drp.1_Missense_Mutation_p.S293L	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	198	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GCCCTGGTTTCAGTCCGTGTT	0.448													97	138					0	0	0.000781405	0	0
OR5H14	403273	broad.mit.edu	37	3	97868711	97868711	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:97868711G>A	uc003dsg.1	+	1	482	c.482G>A	c.(481-483)GGA>GAA	p.G161E		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATCCATGAAGGATTTTTATTC	0.348													39	79					0	0	0.000953801	0	0
ABI3BP	25890	broad.mit.edu	37	3	100645200	100645200	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:100645200G>A	uc003dun.2	-	2	311	c.226C>T	c.(226-228)CCA>TCA	p.P76S	ABI3BP_uc003duo.2_Missense_Mutation_p.P69S|ABI3BP_uc003dup.3_Missense_Mutation_p.P69S	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	76						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						TACTGGTTTGGTGATACATTG	0.468													18	45					0	0	0.000958276	0	0
PCNP	57092	broad.mit.edu	37	3	101311501	101311501	+	Silent	SNP	C	T	T	rs17851951		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:101311501C>T	uc003dva.2	+	5	459	c.441C>T	c.(439-441)TCC>TCT	p.S147S	PCNP_uc003dvb.2_RNA|PCNP_uc003dvc.2_RNA|PCNP_uc003dvd.2_Missense_Mutation_p.L129F	NM_020357	NP_065090	Q8WW12	PCNP_HUMAN	PEST proteolytic signal containing nuclear	147					cell cycle|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	nucleus	protein binding				0						GACCAAACTCCTTCAATAAAG	0.333													28	51					0	0	0.00058488	0	0
NFKBIZ	64332	broad.mit.edu	37	3	101572119	101572119	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:101572119C>T	uc003dvp.2	+	5	864	c.749C>T	c.(748-750)CCC>CTC	p.P250L	NFKBIZ_uc003dvo.2_Missense_Mutation_p.P150L|NFKBIZ_uc010hpo.2_Missense_Mutation_p.P150L|NFKBIZ_uc003dvq.2_Intron	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						CAGAGCTCCCCCGCAGAGCAG	0.517													25	40					0	0	0.00047179	0	0
RETNLB	84666	broad.mit.edu	37	3	108476003	108476003	+	Silent	SNP	G	A	A	rs79104027		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:108476003G>A	uc003dxh.2	-	1	128	c.30C>T	c.(28-30)ATC>ATT	p.I10I		NM_032579	NP_115968	Q9BQ08	RETNB_HUMAN	resistin like beta precursor	10					cell proliferation	extracellular region	hormone activity			skin(1)	1						GGGGGATTAGGATGAGAAGGA	0.512													7	19					0	0	0.000157383	0	0
CD96	10225	broad.mit.edu	37	3	111263901	111263901	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:111263901G>A	uc003dxw.2	+	2	240	c.70G>A	c.(70-72)GAA>AAA	p.E24K	CD96_uc003dxv.2_Missense_Mutation_p.E24K|CD96_uc003dxx.2_Missense_Mutation_p.E24K|CD96_uc010hpy.1_Missense_Mutation_p.E24K	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	24	Extracellular (Potential).				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						AGGAGTTTGGGAAAAAACAGT	0.403									Opitz_Trigonocephaly_syndrome				29	63					0	0	0.001512	0	0
SLC9A10	285335	broad.mit.edu	37	3	111927084	111927084	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:111927084C>T	uc003dyu.2	-	16	2149	c.1927G>A	c.(1927-1929)GAA>AAA	p.E643K	SLC9A10_uc011bhu.1_Intron|SLC9A10_uc010hqc.2_Missense_Mutation_p.E595K	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	643	Ion transport-like.				cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						TGTTTTAATTCGCTGTGGTAG	0.303													81	116					0	0	0.000781405	0	0
SIDT1	54847	broad.mit.edu	37	3	113342554	113342554	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:113342554T>A	uc003eak.2	+	23	2932	c.2281T>A	c.(2281-2283)TTC>ATC	p.F761I	SIDT1_uc011big.1_Missense_Mutation_p.F514I|SIDT1_uc011bii.1_Missense_Mutation_p.F214I	NM_017699	NP_060169	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1 precursor	761	Helical; (Potential).					integral to membrane				ovary(3)|pancreas(1)|skin(1)	5						CCTATATTTTTTCTTCCAGAA	0.532													38	51					0	0	0.00195071	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070718	114070718	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:114070718G>A	uc003ebi.2	-	4	387	c.207C>T	c.(205-207)ATC>ATT	p.I69I	ZBTB20_uc003ebj.2_5'UTR|ZBTB20_uc010hqp.2_5'UTR|ZBTB20_uc003ebk.2_5'UTR|ZBTB20_uc003ebl.2_5'UTR|ZBTB20_uc003ebm.2_5'UTR|ZBTB20_uc003ebn.2_5'UTR|uc003ebo.1_RNA	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	69					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CCTTGCAACTGATGTCACCTG	0.522													30	41					0	0	0.000814825	0	0
POPDC2	64091	broad.mit.edu	37	3	119367478	119367478	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:119367478G>A	uc003ecx.1	-	3	772	c.638C>T	c.(637-639)TCC>TTC	p.S213F	POPDC2_uc010hqw.1_Missense_Mutation_p.S213F|POPDC2_uc003ecy.1_Missense_Mutation_p.S31F	NM_022135	NP_071418	Q9HBU9	POPD2_HUMAN	popeye protein 2	213						integral to membrane				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.242)		CCGGGGCCAGGAAATGTAGCT	0.473													29	44					0	0	0.00111076	0	0
C3orf15	89876	broad.mit.edu	37	3	119462887	119462887	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:119462887C>T	uc003ede.3	+	14	1823	c.1746C>T	c.(1744-1746)TTC>TTT	p.F582F	C3orf15_uc010hqz.2_Silent_p.F520F|C3orf15_uc011bjd.1_Silent_p.F456F|C3orf15_uc011bje.1_Silent_p.F562F	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	418	Potential.					mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		TGTTTGACTTCCTGTCCAAAG	0.507													19	42					0	0	0.00121646	0	0
ARGFX	503582	broad.mit.edu	37	3	121304901	121304901	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:121304901G>A	uc003eef.2	+	5	497	c.402G>A	c.(400-402)AAG>AAA	p.K134K		NM_001012659	NP_001012677	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	134	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.K134N(1)		skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(114;0.152)		TCAAATTGAAGAAGCAGCAGC	0.517													14	31					0	0	0.000566183	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647371	121647371	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:121647371C>T	uc003eep.2	+	15	1463	c.1310C>T	c.(1309-1311)TCT>TTT	p.S437F	SLC15A2_uc011bjn.1_Missense_Mutation_p.S406F	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	437					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GAAAACAATTCTCTGTTGATA	0.413													44	77					0	0	0.000680045	0	0
SLC15A2	6565	broad.mit.edu	37	3	121649724	121649724	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:121649724C>T	uc003eep.2	+	18	1744	c.1591C>T	c.(1591-1593)CTG>TTG	p.L531L	SLC15A2_uc011bjn.1_Silent_p.L500L	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	531					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CAACATCTCCCTGAGTACAGA	0.373													27	28					0	0	0.0024448	0	0
ILDR1	286676	broad.mit.edu	37	3	121712403	121712403	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:121712403G>A	uc003ees.2	-	7	1299	c.1193C>T	c.(1192-1194)TCG>TTG	p.S398L	ILDR1_uc003eeq.2_Missense_Mutation_p.S366L|ILDR1_uc003eer.2_Missense_Mutation_p.S354L|ILDR1_uc010hrg.2_Missense_Mutation_p.S309L	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	398	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		TCCACTCCACGATGGGTCCAA	0.587													17	26					0	0	0.000422831	0	0
CASR	846	broad.mit.edu	37	3	121976192	121976192	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:121976192C>T	uc003eev.3	+	3	822	c.450C>T	c.(448-450)TCC>TCT	p.S150S	CASR_uc003eew.3_Silent_p.S150S	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	150	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAGGCGTCTCCACGGCAGTGG	0.532													25	36					0	0	0.00106085	0	0
MYLK	4638	broad.mit.edu	37	3	123401111	123401111	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:123401111C>T	uc003ego.2	-	20	3894	c.3612G>A	c.(3610-3612)CGG>CGA	p.R1204R	MYLK_uc011bjv.1_Silent_p.R4R|MYLK_uc011bjw.1_Silent_p.R1204R|MYLK_uc003egp.2_Silent_p.R1135R|MYLK_uc003egq.2_Silent_p.R1204R|MYLK_uc003egr.2_Silent_p.R1135R|MYLK_uc003egs.2_Silent_p.R1028R|MYLK_uc003egt.2_Silent_p.R395R	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1204	Actin-binding (calcium/calmodulin- insensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TCTTGGGCCTCCGGGATTTCA	0.562													7	8					0	0	0.000442599	0	0
SLC12A8	84561	broad.mit.edu	37	3	124810994	124810994	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:124810994G>A	uc003ehv.3	-	11	1865	c.1754C>T	c.(1753-1755)TCC>TTC	p.S585F	SLC12A8_uc003ehw.3_Missense_Mutation_p.S614F|SLC12A8_uc003eht.3_Missense_Mutation_p.S386F|SLC12A8_uc003ehu.3_Missense_Mutation_p.S338F|SLC12A8_uc010hry.2_Intron	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	585					potassium ion transport	integral to membrane	symporter activity				0						GAAAGAAGTGGATCTTCTCCA	0.453													31	55					0	0	0.00058488	0	0
MCM2	4171	broad.mit.edu	37	3	127336175	127336175	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:127336175C>T	uc003ejp.2	+	11	1884	c.1827C>T	c.(1825-1827)ATC>ATT	p.I609I	MCM2_uc011bkm.1_Silent_p.I479I|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Silent_p.I562I	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	609	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						AACAGAGCATCTCCATCTCGA	0.582													14	20					0	0	0.000958276	0	0
TMEM108	66000	broad.mit.edu	37	3	133099320	133099320	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:133099320G>A	uc003eph.2	+	4	1039	c.765G>A	c.(763-765)GCG>GCA	p.A255A	TMEM108_uc003epi.2_Silent_p.A255A|TMEM108_uc003epj.1_Silent_p.A255A|TMEM108_uc003epk.2_Intron|TMEM108_uc003epm.2_Silent_p.A206A	NM_023943	NP_076432	Q6UXF1	TM108_HUMAN	transmembrane protein 108 precursor	255	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)	4						CAGTGGCTGCGACCACAGTGC	0.647													9	23					0	0	0.000442599	0	0
CEP70	80321	broad.mit.edu	37	3	138219316	138219317	+	Silent	DNP	GG	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:138219316_138219317GG>TT	uc003esl.2	-	15	1659_1660	c.1461_1462CC>AA	c.(1459-1464)CCCCGA>CCAAGA	p.487_488PR>PR	CEP70_uc011bmk.1_Silent_p.467_468PR>PR|CEP70_uc011bml.1_Silent_p.469_470PR>PR|CEP70_uc011bmm.1_Silent_p.335_336PR>PR|CEP70_uc003esm.2_Silent_p.487_488PR>PR	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	487_488	TPR.				G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						TCATTCATTCGGGGATAGACTC	0.376													9	531					0	0	6.4e-05	0	0
NMNAT3	349565	broad.mit.edu	37	3	139297856	139297856	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:139297856C>T	uc003etj.2	-	2	191	c.151G>A	c.(151-153)GAC>AAC	p.D51N	NMNAT3_uc003etk.2_Missense_Mutation_p.D14N|NMNAT3_uc003etl.2_RNA|NMNAT3_uc010hul.2_Intron	NM_178177	NP_835471	Q96T66	NMNA3_HUMAN	nicotinamide mononucleotide adenylyltransferase	51					water-soluble vitamin metabolic process	cytosol|mitochondrion	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity				0						CCATAGGTGTCGTTGACAGGA	0.572													14	22					0	0	0.000219431	0	0
SLC9A9	285195	broad.mit.edu	37	3	142985627	142985627	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:142985627C>T	uc003evn.2	-	16	2037	c.1855G>A	c.(1855-1857)GAA>AAA	p.E619K		NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	619					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						TAAATGTTTTCCTTGCCTGGC	0.502													39	49					0	0	0.00170553	0	0
AGTR1	185	broad.mit.edu	37	3	148459572	148459572	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:148459572C>T	uc003ewg.2	+	4	1196	c.750C>T	c.(748-750)TTC>TTT	p.F250F	AGTR1_uc003ewh.2_Silent_p.F250F|AGTR1_uc003ewi.2_Silent_p.F250F|AGTR1_uc003ewj.2_Silent_p.F250F|AGTR1_uc003ewk.2_Silent_p.F250F	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	250	Helical; Name=6; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TTTTCTTTTTCTTTTCCTGGA	0.353													32	37					0	0	0.0024448	0	0
FAM194A	131831	broad.mit.edu	37	3	150404140	150404140	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:150404140C>T	uc003eyg.2	-	4	612	c.555G>A	c.(553-555)AGG>AGA	p.R185R	FAM194A_uc003eyh.2_Silent_p.R39R	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	185										skin(2)|ovary(1)	3						AGGCTTTCTTCCCTGTGAAAA	0.363													27	39					0	0	0.001512	0	0
MED12L	116931	broad.mit.edu	37	3	150911442	150911442	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:150911442C>T	uc003eyp.2	+	14	2172	c.2134C>T	c.(2134-2136)CCT>TCT	p.P712S	MED12L_uc011bnz.1_Missense_Mutation_p.P572S|MED12L_uc003eyn.2_Missense_Mutation_p.P747S|MED12L_uc003eyo.2_Missense_Mutation_p.P712S	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	712					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AACACATTTTCCTATACCTCT	0.338													37	49					0	0	0.00195071	0	0
P2RY14	9934	broad.mit.edu	37	3	150931715	150931715	+	Silent	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:150931715A>T	uc003eyr.1	-	3	868	c.390T>A	c.(388-390)TCT>TCA	p.S130S	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Silent_p.S130S	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	130	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTGGATGAAAGAAGTCCAAA	0.423													7	41					0	0	0.000157383	0	0
AADACL2	344752	broad.mit.edu	37	3	151463442	151463442	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:151463442A>G	uc003ezc.2	+	4	697	c.577A>G	c.(577-579)AAT>GAT	p.N193D	AADACL2_uc010hvn.2_5'UTR	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	193						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TTCTGGGGGCAATTTAGCAAC	0.308													24	44					0	0	0.000720815	0	0
SGEF	26084	broad.mit.edu	37	3	153905608	153905608	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:153905608G>A	uc011bog.1	+	7	1833	c.1622G>A	c.(1621-1623)CGA>CAA	p.R541Q	SGEF_uc011boh.1_Missense_Mutation_p.R541Q	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	541	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TACCAACAACGAACACTACAA	0.323													6	22					0	0	0.000157383	0	0
GPR149	344758	broad.mit.edu	37	3	154138962	154138962	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:154138962C>T	uc003faa.2	-	3	1589	c.1489G>A	c.(1489-1491)GGA>AGA	p.G497R		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	497	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			ATATCACCTCCTGTTTTGTCA	0.403													65	66					0	0	0.000781405	0	0
MME	4311	broad.mit.edu	37	3	154898211	154898211	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:154898211C>T	uc010hvr.1	+	23	2427	c.2216C>T	c.(2215-2217)TCA>TTA	p.S739L	MME_uc003fab.1_Missense_Mutation_p.S739L|MME_uc003fac.1_Missense_Mutation_p.S739L|MME_uc003fad.1_Missense_Mutation_p.S739L|MME_uc003fae.1_Missense_Mutation_p.S739L	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	739	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	CGCAAGAATTCATACATGAAT	0.428													53	111					0	0	0.000781405	0	0
PLCH1	23007	broad.mit.edu	37	3	155215185	155215185	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:155215185G>A	uc011bok.1	-	14	2059	c.1782C>T	c.(1780-1782)ACC>ACT	p.T594T	PLCH1_uc011boj.1_Silent_p.T594T|PLCH1_uc011bol.1_Silent_p.T576T	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	594					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AGAGCTTCATGGTTTTCCTTC	0.468													28	59					0	0	0.00178596	0	0
PLD1	5337	broad.mit.edu	37	3	171330184	171330184	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:171330184G>A	uc003fhs.2	-	25	2883	c.2767C>T	c.(2767-2769)CGT>TGT	p.R923C	PLD1_uc003fht.2_Missense_Mutation_p.R885C|PLD1_uc003fhu.3_Missense_Mutation_p.R217C	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	923	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TCACTGTCACGCTTTCCCAGC	0.438													25	37					0	0	0.000878237	0	0
NLGN1	22871	broad.mit.edu	37	3	173998905	173998905	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:173998905T>A	uc003fio.1	+	7	2707	c.2284T>A	c.(2284-2286)TAC>AAC	p.Y762N	NLGN1_uc003fip.1_Missense_Mutation_p.Y762N	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	779	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TCCCCCAGATTACACACTAGC	0.468													17	37					0	0	0.000958276	0	0
DGKG	1608	broad.mit.edu	37	3	185969597	185969597	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:185969597C>T	uc003fqa.2	-	19	2249	c.1712G>A	c.(1711-1713)GGG>GAG	p.G571E	DGKG_uc003fqb.2_Missense_Mutation_p.G532E|DGKG_uc003fqc.2_Missense_Mutation_p.G546E|DGKG_uc011brx.1_Missense_Mutation_p.G512E	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	571					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	GACCTGGTCCCCGTTTTCCAC	0.507													44	64					0	0	0.000509022	0	0
TP63	8626	broad.mit.edu	37	3	189612028	189612028	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:189612028C>T	uc003fry.2	+	14	1869	c.1780C>T	c.(1780-1782)CGA>TGA	p.R594*	TP63_uc003frz.2_3'UTR|TP63_uc010hzc.1_3'UTR|TP63_uc003fsc.2_Nonsense_Mutation_p.R500*|TP63_uc003fsd.2_3'UTR|TP63_uc010hzd.1_Nonsense_Mutation_p.R415*	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	594	SAM.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGAGCAATTTCGACATGCGAT	0.532									Hay-Wells_syndrome	HNSCC(45;0.13)			26	37					0	0	0.00127121	0	0
CLDN16	10686	broad.mit.edu	37	3	190106098	190106098	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:190106098C>T	uc003fsi.2	+	1	258	c.190C>T	c.(190-192)CCT>TCT	p.P64S	CLDN16_uc010hze.2_Missense_Mutation_p.P64S	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	64	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		ATGTTGCCATCCTGATGGGCT	0.498													13	36					0	0	0.00136819	0	0
RNF168	165918	broad.mit.edu	37	3	196215511	196215511	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:196215511T>C	uc003fwq.2	-	2	883	c.345A>G	c.(343-345)GAA>GAG	p.E115E	RNF168_uc010iah.2_Intron	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	115	Glu-rich.				double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		CTCTTCTCAGTTCCCCAGGTT	0.318													22	42					0	0	0.000878237	0	0
KIAA0226	9711	broad.mit.edu	37	3	197403774	197403774	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr3:197403774G>A	uc003fyc.2	-	18	2811	c.2628C>T	c.(2626-2628)ACC>ACT	p.T876T	KIAA0226_uc003fyd.3_Silent_p.T831T|MIR922_hsa-mir-922|MI0005714_5'Flank|KIAA0226_uc003fye.1_Silent_p.T608T	NM_014687	NP_055502	Q92622	RUBIC_HUMAN	hypothetical protein LOC9711 isoform 2.	876					autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding				0	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TCTCCACATGGGTAGCCCCTG	0.597													15	33					0	0	0.00121646	0	0
ZNF721	170960	broad.mit.edu	37	4	438156	438156	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:438156G>A	uc003gag.2	-	3	791	c.100C>T	c.(100-102)CTT>TTT	p.L34F	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Missense_Mutation_p.L66F|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.L66F|ZNF721_uc010ibe.2_Missense_Mutation_p.L22F	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	34						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CTCAGTATAAGTTTGTGGAAT	0.348													43	33					0	0	0.00170553	0	0
FAM53A	152877	broad.mit.edu	37	4	1656818	1656818	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:1656818G>A	uc011bve.1	-	4	967	c.769C>T	c.(769-771)CGG>TGG	p.R257W	FAM53A_uc010ibw.2_Missense_Mutation_p.R257W	NM_001013622	NP_001013644	Q6NSI3	FA53A_HUMAN	dorsal neural-tube nuclear protein	257						nucleus					0		all_epithelial(65;0.206)|Breast(71;0.212)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)			GAGCGGCACCGGAGCAGCCCA	0.716													13	10					0	0	0.00136819	0	0
TACC3	10460	broad.mit.edu	37	4	1729447	1729447	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:1729447C>T	uc003gdo.2	+	4	426	c.318C>T	c.(316-318)ATC>ATT	p.I106I	TACC3_uc010ibz.2_Silent_p.I106I|TACC3_uc003gdp.2_Intron	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	106						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			AACAGCTCATCAAGGAAGTGG	0.423													128	320					0	0	0.000781405	0	0
FGFR3	2261	broad.mit.edu	37	4	1801058	1801058	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:1801058C>T	uc003gdr.3	+	3	443	c.187C>T	c.(187-189)CCG>TCG	p.P63S	FGFR3_uc003gdu.2_Missense_Mutation_p.P63S|FGFR3_uc003gds.3_Missense_Mutation_p.P63S|FGFR3_uc003gdq.3_Missense_Mutation_p.P63S|FGFR3_uc010icb.1_5'Flank|FGFR3_uc003gdt.1_5'Flank	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	63	Ig-like C2-type 1.|Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GAGCTGTCCCCCGCCCGGGGG	0.697		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				56	34					0	0	0.000781405	0	0
HTT	3064	broad.mit.edu	37	4	3129175	3129175	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:3129175C>T	uc011bvq.1	+	13	1738	c.1593C>T	c.(1591-1593)ATC>ATT	p.I531I		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	529		Cleavage; by apopain (Potential).			establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		AGGAGGATATCTTGAGCCACA	0.612													14	35					0	0	0.000219431	0	0
CPEB2	132864	broad.mit.edu	37	4	15005680	15005680	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:15005680C>T	uc003gni.1	+	1	159	c.72C>T	c.(70-72)TTC>TTT	p.F24F	uc003gng.3_5'Flank|uc003gnh.1_5'Flank|CPEB2_uc003gnj.1_Silent_p.F24F|CPEB2_uc003gnk.1_Silent_p.F24F|CPEB2_uc003gnl.1_Silent_p.F24F|CPEB2_uc003gnm.1_Silent_p.F24F|CPEB2_uc003gnn.1_Silent_p.F24F	NM_182485	NP_872291	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding	24	Pro-rich.				regulation of translation	cytoplasm	nucleotide binding|RNA binding			skin(1)	1						ACCCGGCCTTCTTCCCTAGCT	0.607													11	22					0	0	0.00136819	0	0
DCAF16	54876	broad.mit.edu	37	4	17805353	17805353	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:17805353G>A	uc003gpn.2	-	3	1473	c.412C>T	c.(412-414)CAT>TAT	p.H138Y	DCAF16_uc003gpo.2_RNA	NM_017741	NP_060211	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	138						CUL4 RING ubiquitin ligase complex				ovary(1)	1						AGAGTGGCATGATCTCTAGAG	0.498													69	177					0	0	0.000781405	0	0
SLIT2	9353	broad.mit.edu	37	4	20598053	20598053	+	Missense_Mutation	SNP	G	C	C	rs151150739	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:20598053G>C	uc003gpr.1	+	32	3540	c.3336G>C	c.(3334-3336)GAG>GAC	p.E1112D	SLIT2_uc003gps.1_Missense_Mutation_p.E1104D	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1112	EGF-like 5; calcium-binding (Potential).				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						TGTTCTGTGAGTTTTCTCCAC	0.378													27	69					0	0	0.000692331	0	0
SLIT2	9353	broad.mit.edu	37	4	20611774	20611774	+	Silent	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:20611774T>A	uc003gpr.1	+	34	4035	c.3831T>A	c.(3829-3831)TCT>TCA	p.S1277S	SLIT2_uc003gps.1_Silent_p.S1269S	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1277	Laminin G-like.		S -> F.		apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATTTTGACTCTCCACTCTATG	0.428													28	22					0	0	0.000878237	0	0
ANAPC4	29945	broad.mit.edu	37	4	25379079	25379079	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:25379079C>T	uc003gro.2	+	2	159	c.30C>T	c.(28-30)TCC>TCT	p.S10S		NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	10					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				GTTTCCCATCCTTCCGGGTGG	0.632													11	36					0	0	0.00136819	0	0
N4BP2	55728	broad.mit.edu	37	4	40108641	40108641	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:40108641C>T	uc003guy.3	+	5	1833	c.1495C>T	c.(1495-1497)CGT>TGT	p.R499C	N4BP2_uc010ifq.2_Missense_Mutation_p.R419C|N4BP2_uc010ifr.2_Missense_Mutation_p.R419C	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	499						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GAACCAGAATCGTGGTAAGAA	0.294													23	40					0	0	0.000586117	0	0
TEC	7006	broad.mit.edu	37	4	48147256	48147256	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:48147256G>A	uc003gxz.2	-	14	1401	c.1310C>T	c.(1309-1311)CCA>CTA	p.P437L		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	437	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						AATGTATATTGGTTTCTGCTG	0.433													28	45					0	0	0.00209593	0	0
GRSF1	2926	broad.mit.edu	37	4	71691860	71691860	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:71691860T>C	uc010iia.1	-	7	1321	c.1238A>G	c.(1237-1239)AAT>AGT	p.N413S	GRSF1_uc011caz.1_Missense_Mutation_p.N295S|GRSF1_uc003hfs.2_Missense_Mutation_p.N251S	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	413	RRM 3.				mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			GTCTTGGGCATTGGCTTGGAA	0.398													19	10					0	0	0.000375601	0	0
ART3	419	broad.mit.edu	37	4	77003118	77003118	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:77003118G>A	uc003hjo.2	+	3	330	c.211G>A	c.(211-213)GAA>AAA	p.E71K	ART3_uc003hji.2_Missense_Mutation_p.E71K|ART3_uc003hjj.2_Missense_Mutation_p.E71K|ART3_uc003hjk.2_Missense_Mutation_p.E71K|ART3_uc010ija.1_Missense_Mutation_p.E71K|ART3_uc003hjn.2_Missense_Mutation_p.E71K|ART3_uc003hjp.2_Intron|ART3_uc010ijb.2_Intron|ART3_uc003hjq.2_Intron|ART3_uc003hjr.2_Missense_Mutation_p.E41K|ART3_uc010ijc.2_Missense_Mutation_p.E41K|ART3_uc010ijd.2_Missense_Mutation_p.E41K	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	71					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TACTGTGTGGGAAAATGCAAA	0.413													26	8					0	0	0.000586117	0	0
NAA11	84779	broad.mit.edu	37	4	80246535	80246535	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:80246535T>C	uc003hlt.3	-	1	637	c.497A>G	c.(496-498)AAG>AGG	p.K166R		NM_032693	NP_116082	Q9BSU3	NAA11_HUMAN	alpha-N-acetyltransferase 1B	166						cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2						ATACCCGCCCTTCTTCAGGTC	0.537													10	5					0	0	0.000442599	0	0
PRKG2	5593	broad.mit.edu	37	4	82125774	82125774	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:82125774G>A	uc003hmh.2	-	1	442	c.428C>T	c.(427-429)TCC>TTC	p.S143F	PRKG2_uc011cch.1_Missense_Mutation_p.S143F	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	143					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						TTTCTCAAAGGAAAATTCAGG	0.453													117	92					0	0	0.000781405	0	0
WDFY3	23001	broad.mit.edu	37	4	85731479	85731479	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:85731479G>A	uc003hpd.2	-	14	2314	c.1906C>T	c.(1906-1908)CGA>TGA	p.R636*	WDFY3_uc003hpf.2_Nonsense_Mutation_p.R636*	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	636						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGGCTTTCTCGAAGGACCGAC	0.383													13	9					0	0	0.00185496	0	0
PTPN13	5783	broad.mit.edu	37	4	87724993	87724993	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:87724993C>T	uc003hpz.2	+	43	7117	c.6637C>T	c.(6637-6639)CCT>TCT	p.P2213S	PTPN13_uc003hpy.2_Missense_Mutation_p.P2218S|PTPN13_uc003hqa.2_Missense_Mutation_p.P2194S|PTPN13_uc003hqb.2_Missense_Mutation_p.P2022S|PTPN13_uc003hqc.1_Missense_Mutation_p.P579S	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2213	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCAAGGAATTCCTTCTAAGGA	0.443													44	21					0	0	0.000781405	0	0
DSPP	1834	broad.mit.edu	37	4	88534101	88534101	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:88534101G>A	uc003hqu.2	+	4	883	c.763G>A	c.(763-765)GAA>AAA	p.E255K		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	255					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AGATGAGGATGAAGACGAGGG	0.502													21	13					0	0	0.000586117	0	0
PPP3CA	5530	broad.mit.edu	37	4	102117259	102117259	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:102117259G>A	uc011cen.1	-	2	748	c.73C>T	c.(73-75)CCA>TCA	p.P25S	PPP3CA_uc003hvu.2_Missense_Mutation_p.P25S|PPP3CA_uc010ilj.2_Missense_Mutation_p.P25S|PPP3CA_uc003hvt.2_Missense_Mutation_p.P12S|PPP3CA_uc003hvs.2_Intron|PPP3CA_uc010ilk.2_Missense_Mutation_p.P25S	NM_000944	NP_000935	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha	25	Catalytic.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		CGGTGACTTGGAGGAAATGGA	0.393													12	11					0	0	0.00136819	0	0
GAR1	54433	broad.mit.edu	37	4	110745127	110745127	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:110745127T>A	uc003hzt.2	+	6	885	c.578T>A	c.(577-579)TTT>TAT	p.F193Y	GAR1_uc003hzu.2_Missense_Mutation_p.F193Y|GAR1_uc010imi.2_Intron	NM_018983	NP_061856	Q9NY12	GAR1_HUMAN	nucleolar protein family A, member 1	193	RGG-box 2.				rRNA processing|snRNA pseudouridine synthesis	box H/ACA snoRNP complex|Cajal body	cation channel activity|pseudouridine synthase activity|snoRNA binding				0						TTAGGTGGTTTTAGAGGTGGA	0.313													71	31					0	0	0.000781405	0	0
SLC25A31	83447	broad.mit.edu	37	4	128685492	128685492	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:128685492G>A	uc003ifl.2	+	3	601	c.455G>A	c.(454-456)CGA>CAA	p.R152Q		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	152	Solcar 2.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						GCCCGAACCCGATTAGGTGTC	0.398													34	24					0	0	0.000491102	0	0
CLGN	1047	broad.mit.edu	37	4	141320054	141320054	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:141320054C>T	uc011chi.1	-	9	1053	c.835G>A	c.(835-837)GAT>AAT	p.D279N	CLGN_uc003iii.2_Missense_Mutation_p.D279N	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	279	Lumenal (Potential).|1-1.				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					GCTCTTTCATCCCATTCCTCA	0.363													47	43					0	0	0.000781405	0	0
ZNF827	152485	broad.mit.edu	37	4	146823846	146823846	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:146823846A>T	uc003ikn.2	-	2	613	c.565T>A	c.(565-567)TTT>ATT	p.F189I	ZNF827_uc003ikm.2_Missense_Mutation_p.F189I|ZNF827_uc010iox.2_Intron	NM_178835	NP_849157	Q17R98	ZN827_HUMAN	zinc finger protein 827	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_hematologic(180;0.151)					TTCCATATAAAACGGTTACTT	0.517													26	16					0	0	0.000586117	0	0
TLR2	7097	broad.mit.edu	37	4	154626372	154626372	+	Silent	SNP	G	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:154626372G>C	uc003inq.2	+	3	2532	c.2313G>C	c.(2311-2313)CGG>CGC	p.R771R	TLR2_uc003inr.2_Silent_p.R771R|TLR2_uc003ins.2_Silent_p.R771R	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	771	TIR.|Cytoplasmic (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				AGGCTCAGCGGGAAGGATTTT	0.473													27	16					0	0	0.00127121	0	0
DCHS2	54798	broad.mit.edu	37	4	155219727	155219727	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:155219727C>T	uc003inw.2	-	18	4374	c.4374G>A	c.(4372-4374)AGG>AGA	p.R1458R		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1458	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTACAGAGCTCCTAGGTGGAT	0.473													37	20					0	0	0.00111076	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156638326	156638326	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:156638326G>A	uc003iov.2	+	9	2124	c.1588G>A	c.(1588-1590)GAT>AAT	p.D530N	GUCY1A3_uc010iqc.2_Missense_Mutation_p.D530N|GUCY1A3_uc003iow.2_Missense_Mutation_p.D530N|GUCY1A3_uc010iqd.2_Missense_Mutation_p.D529N|GUCY1A3_uc003iox.2_Missense_Mutation_p.D530N|GUCY1A3_uc003ioz.2_Missense_Mutation_p.D295N|GUCY1A3_uc003ioy.2_Missense_Mutation_p.D530N|GUCY1A3_uc010iqe.2_Missense_Mutation_p.D295N|GUCY1A3_uc003ipa.2_RNA|GUCY1A3_uc003ipb.2_Missense_Mutation_p.D530N	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	530	Guanylate cyclase.			GDAYCVA -> AMPIVWL (in Ref. 1; CAA47145).	blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		GACCATTGGCGATGCCTATTG	0.408													23	14					0	0	0.00127121	0	0
NPY1R	4886	broad.mit.edu	37	4	164247360	164247360	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:164247360T>A	uc003iqm.1	-	2	613	c.347A>T	c.(346-348)AAT>ATT	p.N116I	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	116	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CACAAAAGGATTCAACTTACA	0.448													10	7					0	0	0.000673444	0	0
NPY1R	4886	broad.mit.edu	37	4	164247362	164247362	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr4:164247362C>A	uc003iqm.1	-	2	611	c.345G>T	c.(343-345)TTG>TTT	p.L115F	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	115	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CAAAAGGATTCAACTTACACA	0.443													10	9					1.58986e-06	6.61205e-06	0.000673444	1	0
PAPD7	11044	broad.mit.edu	37	5	6751215	6751215	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:6751215C>T	uc003jdx.1	+	11	1303	c.1174C>T	c.(1174-1176)CCT>TCT	p.P392S	PAPD7_uc011cmn.1_Missense_Mutation_p.P383S|PAPD7_uc010itl.1_Missense_Mutation_p.P212S	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	392					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						AGCGCCAGCTCCTCTCATGGC	0.537													22	59					0	0	0.00047179	0	0
C5orf49	134121	broad.mit.edu	37	5	7835598	7835598	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:7835598G>A	uc003jea.3	-	2	291	c.161C>T	c.(160-162)TCC>TTC	p.S54F		NM_001089584	NP_001083053	A4QMS7	CE049_HUMAN	hypothetical protein LOC134121	54											0						ATCATAGAGGGAAATAATTCC	0.428													23	35					0	0	0.000586117	0	0
DNAH5	1767	broad.mit.edu	37	5	13780988	13780988	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:13780988C>T	uc003jfd.2	-	53	8943	c.8901G>A	c.(8899-8901)AGG>AGA	p.R2967R		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2967	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATGAAGCCAACCTCGTCAGGC	0.468									Kartagener_syndrome				18	21					0	0	0.000958276	0	0
DNAH5	1767	broad.mit.edu	37	5	13841889	13841889	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:13841889G>A	uc003jfd.2	-	33	5438	c.5396C>T	c.(5395-5397)TCA>TTA	p.S1799L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1799	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AAGATGCAATGAGGACTGAGA	0.438									Kartagener_syndrome				27	39					0	0	0.001512	0	0
DNAH5	1767	broad.mit.edu	37	5	13891132	13891132	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:13891132G>A	uc003jfd.2	-	17	2572	c.2530C>T	c.(2530-2532)CCC>TCC	p.P844S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	844	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCCTCCTGGGGAAGCTGACAA	0.423									Kartagener_syndrome				71	107					0	0	0.000781405	0	0
ANKH	56172	broad.mit.edu	37	5	14769104	14769104	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:14769104G>A	uc003jfm.3	-	2	624	c.293C>T	c.(292-294)GCC>GTC	p.A98V		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	98	Helical; (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						GTGAAAGACGGCAGCGATGGC	0.483													29	40					0	0	0.0024448	0	0
CDH6	1004	broad.mit.edu	37	5	31305377	31305377	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:31305377G>A	uc003jhe.1	+	7	1422	c.1096G>A	c.(1096-1098)GAT>AAT	p.D366N	CDH6_uc003jhd.1_Missense_Mutation_p.D366N	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	366	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						GCCTTTCAAAGATTCAGCCAC	0.428													26	36					0	0	0.000720815	0	0
CDH6	1004	broad.mit.edu	37	5	31313484	31313484	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:31313484G>A	uc003jhe.1	+	8	1639	c.1313G>A	c.(1312-1314)GGT>GAT	p.G438D	CDH6_uc003jhd.1_Missense_Mutation_p.G438D	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	438	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TCTGGAAATGGTTCGATTTTT	0.388													53	55					0	0	0.000781405	0	0
PDZD2	23037	broad.mit.edu	37	5	32058184	32058184	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:32058184C>T	uc003jhl.2	+	12	2563	c.2175C>T	c.(2173-2175)ATC>ATT	p.I725I	PDZD2_uc003jhm.2_Silent_p.I725I|PDZD2_uc011cnx.1_Silent_p.I551I	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	725					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGGACAGGATCGTCATGGAAG	0.483													16	22					0	0	0.00152264	0	0
PRLR	5618	broad.mit.edu	37	5	35065712	35065712	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:35065712G>A	uc003jjm.2	-	10	1878	c.1348C>T	c.(1348-1350)CTG>TTG	p.L450L	PRLR_uc003jjg.1_Intron|PRLR_uc003jjh.1_Intron|PRLR_uc003jji.1_Intron|PRLR_uc003jjj.1_Intron|PRLR_uc003jjk.1_Intron|PRLR_uc003jjl.3_Silent_p.L349L	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	450	Cytoplasmic (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TCATTCAACAGAGTGGCCGGT	0.512													40	88					0	0	0.000781405	0	0
EGFLAM	133584	broad.mit.edu	37	5	38406929	38406929	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:38406929G>A	uc003jlc.1	+	8	1153	c.829_splice	c.e8-1	p.V277_splice	EGFLAM_uc003jlb.1_Splice_Site_p.V277_splice|EGFLAM_uc003jle.1_Splice_Site_p.V43_splice|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G							cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					TCTGGCTTTAGGTTAAACCAC	0.398													15	16					0	0	0.000308642	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41019062	41019062	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:41019062G>A	uc003jmj.3	-	25	2990	c.2500C>T	c.(2500-2502)CGG>TGG	p.R834W	HEATR7B2_uc003jmi.3_Missense_Mutation_p.R389W	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	834							binding			ovary(6)|central_nervous_system(2)	8						AGCAGCCTCCGAATATTCTCC	0.463													10	35					0	0	0.000673444	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41038872	41038872	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:41038872G>A	uc003jmj.3	-	21	2670	c.2180C>T	c.(2179-2181)TCC>TTC	p.S727F	HEATR7B2_uc003jmi.3_Missense_Mutation_p.S282F	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	727							binding			ovary(6)|central_nervous_system(2)	8						CAGGACTTGGGATATGATATC	0.507													12	26					0	0	0.00136819	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41061769	41061770	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:41061769_41061770GG>AA	uc003jmj.3	-	6	1007_1008	c.517_518CC>TT	c.(517-519)CCC>TTC	p.P173F		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	173							binding			ovary(6)|central_nervous_system(2)	8						TCTGGGGTAGGGAAAATCTCTC	0.45													30	65					0	0	6.4e-05	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41065470	41065470	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:41065470G>A	uc003jmj.3	-	4	814	c.324C>T	c.(322-324)TTC>TTT	p.F108F		NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	108							binding			ovary(6)|central_nervous_system(2)	8						CAAGCACAACGAATTCATCTG	0.418													11	24					0	0	0.000673444	0	0
C6	729	broad.mit.edu	37	5	41150037	41150037	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:41150037C>T	uc003jmk.2	-	16	2591	c.2381G>A	c.(2380-2382)AGC>AAC	p.S794N	C6_uc003jml.1_Missense_Mutation_p.S794N	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	794	C5b-binding domain.|Complement control factor I module 1.|Kazal-like 1.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TATCTCTTACCTACAGTCTTC	0.294													17	30					0	0	0.000958276	0	0
ESM1	11082	broad.mit.edu	37	5	54281074	54281074	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:54281074G>A	uc003jpk.2	-	1	341	c.272C>T	c.(271-273)CCT>CTT	p.P91L	ESM1_uc010ivt.2_Missense_Mutation_p.P91L	NM_007036	NP_008967	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1 isoform a	91	IGFBP N-terminal.				angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			TTCACCAAAAGGATCCTCCCC	0.572													43	66					0	0	0.000589545	0	0
DDX4	54514	broad.mit.edu	37	5	55110939	55110939	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:55110939C>T	uc003jqg.3	+	20	2000	c.1926C>T	c.(1924-1926)TCC>TCT	p.S642S	DDX4_uc010ivz.2_Silent_p.S622S|DDX4_uc003jqh.3_Silent_p.S608S|DDX4_uc003jqj.2_Silent_p.S493S	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	642	Helicase C-terminal.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				GAGCAATTTCCTTTTTTGATC	0.358													52	88					0	0	0.000781405	0	0
GAPT	202309	broad.mit.edu	37	5	57790678	57790678	+	Silent	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:57790678A>T	uc003jro.1	+	3	709	c.315A>T	c.(313-315)GGA>GGT	p.G105G		NM_152687	NP_689900	Q8N292	GAPT_HUMAN	GRB2-binding adaptor protein, transmembrane	105					B cell activation	integral to membrane|plasma membrane					0						AAGCTAAAGGAAAAACCGATA	0.403													39	46					0	0	0.00128727	0	0
IPO11	51194	broad.mit.edu	37	5	61832575	61832575	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:61832575T>C	uc003jtc.2	+	23	2326	c.2136T>C	c.(2134-2136)GGT>GGC	p.G712G	IPO11_uc011cqr.1_Silent_p.G752G|IPO11_uc003jtd.1_RNA|IPO11_uc010iwr.2_Intron	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	712	HEAT 10.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TCATCAATGGTTATATCTTTT	0.229													19	24					0	0	0.00121646	0	0
RNF180	285671	broad.mit.edu	37	5	63496695	63496695	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:63496695C>T	uc003jti.2	+	2	171	c.61C>T	c.(61-63)CGT>TGT	p.R21C	RNF180_uc003jth.3_Missense_Mutation_p.R21C|RNF180_uc010iws.2_Missense_Mutation_p.R21C	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	21	Cytoplasmic (Potential).			SILRC -> GETVFSL (in Ref. 2; CAD89939).		integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		AAGTATTCTTCGTTGTTGGAA	0.333													20	43					0	0	0.00121646	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64569260	64569260	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:64569260C>T	uc003jtp.2	-	12	2341	c.1527G>A	c.(1525-1527)GAG>GAA	p.E509E	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA|ADAMTS6_uc003jtr.1_Silent_p.E130E	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	509	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GACACCAGAGCTCTCTACACA	0.433													47	73					0	0	0.000781405	0	0
BDP1	55814	broad.mit.edu	37	5	70855835	70855835	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:70855835T>A	uc003kbp.1	+	37	7530	c.7267T>A	c.(7267-7269)TTT>ATT	p.F2423I	BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2423					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		ACAAGATATTTTTCTTACCTC	0.408													23	35					0	0	0.000720815	0	0
HEXB	3074	broad.mit.edu	37	5	73989524	73989524	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:73989524T>A	uc003kdf.3	+	3	623	c.506T>A	c.(505-507)TTA>TAA	p.L169*	HEXB_uc003kdd.2_5'UTR|HEXB_uc003kde.2_Nonsense_Mutation_p.L169*|HEXB_uc010izh.2_RNA	NM_000521	NP_000512	P07686	HEXB_HUMAN	hexosaminidase B preproprotein	169					cell death	lysosome	cation binding|protein heterodimerization activity|protein homodimerization activity			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.72e-57)		TGGGGAGCATTACGAGGTAAG	0.383													29	35					0	0	0.00058488	0	0
IQGAP2	10788	broad.mit.edu	37	5	75997022	75997022	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:75997022G>A	uc003kek.2	+	34	4711	c.4489G>A	c.(4489-4491)GAT>AAT	p.D1497N	IQGAP2_uc011csv.1_Missense_Mutation_p.D993N|IQGAP2_uc003kel.2_Missense_Mutation_p.D993N	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	1497					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		AGATATAGATGATCTTCAAAC	0.463													29	38					0	0	0.000692331	0	0
F2RL1	2150	broad.mit.edu	37	5	76129487	76129488	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:76129487_76129488GG>TT	uc003keo.2	+	2	1230_1231	c.1055_1056GG>TT	c.(1054-1056)AGG>ATT	p.R352I		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	352	Cytoplasmic (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		CATGATTTCAGGGATCATGCAA	0.475													16	516					0	0	6.4e-05	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79747353	79747353	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:79747353C>T	uc003kgr.3	+	11	3734	c.3432C>T	c.(3430-3432)CTC>CTT	p.L1144L	ZFYVE16_uc003kgp.2_Silent_p.L1144L|ZFYVE16_uc003kgq.3_Silent_p.L1144L|ZFYVE16_uc003kgs.3_Silent_p.L1144L|ZFYVE16_uc003kgt.3_Silent_p.L232L|ZFYVE16_uc003kgu.3_5'Flank	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1144					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AGAGTTTTCTCAGTAGCAAGG	0.303													24	35					0	0	0.000720815	0	0
GPR98	84059	broad.mit.edu	37	5	89949088	89949088	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:89949088C>T	uc003kju.2	+	20	3793	c.3697C>T	c.(3697-3699)CCA>TCA	p.P1233S	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	1233	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGTAATGGTTCCATTCAATGA	0.423													12	28					0	0	0.000978159	0	0
GPR98	84059	broad.mit.edu	37	5	89990185	89990185	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:89990185T>A	uc003kju.2	+	33	7708	c.7612T>A	c.(7612-7614)TTT>ATT	p.F2538I	GPR98_uc003kjt.2_Missense_Mutation_p.F244I|GPR98_uc003kjv.2_Missense_Mutation_p.F138I	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2538	Extracellular (Potential).|Calx-beta 17.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GGATGAGAGTTTTCTAATTTC	0.418													24	50					0	0	0.00047179	0	0
GPR98	84059	broad.mit.edu	37	5	90020993	90020993	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:90020993G>A	uc003kju.2	+	47	10093	c.9997G>A	c.(9997-9999)GAA>AAA	p.E3333K	GPR98_uc003kjt.2_Missense_Mutation_p.E1039K|GPR98_uc003kjv.2_Missense_Mutation_p.E933K	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3333	Extracellular (Potential).|EAR 2.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGAAATGAAGAAAAGCCTTC	0.274													8	30					0	0	0.000274275	0	0
PCSK1	5122	broad.mit.edu	37	5	95728987	95728987	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:95728987C>T	uc003kls.1	-	14	2186	c.1980G>A	c.(1978-1980)GAG>GAA	p.E660E	PCSK1_uc010jbi.1_Silent_p.E350E	NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	660					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AAGGGGCTCCCTCCTCCAACT	0.562													21	47					0	0	0.00121646	0	0
PCSK1	5122	broad.mit.edu	37	5	95761620	95761620	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:95761620T>C	uc003kls.1	-	3	506	c.300A>G	c.(298-300)GAA>GAG	p.E100E		NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	100					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CATACTGTTGTTCAGCCCATA	0.378													17	23					0	0	0.00188189	0	0
FER	2241	broad.mit.edu	37	5	108523217	108523217	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:108523217C>T	uc003kop.1	+	20	2794	c.2410C>T	c.(2410-2412)CGC>TGC	p.R804C	FER_uc011cvg.1_Missense_Mutation_p.R629C	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	804	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ACCTGAAAATCGCCCTAAGTT	0.453													33	35					0	0	0.0024448	0	0
YTHDC2	64848	broad.mit.edu	37	5	112896808	112896808	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:112896808C>T	uc003kqn.2	+	18	2431	c.2248C>T	c.(2248-2250)CGT>TGT	p.R750C	YTHDC2_uc010jcf.1_Missense_Mutation_p.R450C	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	750	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AATTTGTTTTCGTCTGTTCAG	0.338													9	33					0	0	0.000673444	0	0
AQPEP	206338	broad.mit.edu	37	5	115336900	115336900	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:115336900T>C	uc003kro.2	+	10	1948	c.1784T>C	c.(1783-1785)CTT>CCT	p.L595P	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	595	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						CCATTTTATCTTGAAAACATT	0.413													38	79					0	0	0.000509022	0	0
MYOT	9499	broad.mit.edu	37	5	137223019	137223019	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:137223019G>A	uc011cye.1	+	10	1459	c.1442G>A	c.(1441-1443)GGA>GAA	p.G481E	PKD2L2_uc010jep.1_5'Flank|PKD2L2_uc003lbw.1_5'Flank|PKD2L2_uc003lbx.2_5'Flank|PKD2L2_uc003lby.2_5'Flank|MYOT_uc003lbv.2_Missense_Mutation_p.G481E|MYOT_uc011cyg.1_Missense_Mutation_p.G297E|MYOT_uc011cyh.1_Missense_Mutation_p.G366E	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	myotilin isoform b	481	Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AACCCAGAAGGAGAATTTCAG	0.383													27	36					0	0	0.000720815	0	0
HARS2	23438	broad.mit.edu	37	5	140075147	140075147	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140075147C>T	uc003lgx.2	+	5	670	c.454C>T	c.(454-456)CAT>TAT	p.H152Y	HARS2_uc010jfv.1_Missense_Mutation_p.H82Y|HARS2_uc011czr.1_Missense_Mutation_p.H127Y|HARS2_uc011czs.1_Intron|HARS2_uc011czt.1_Intron|HARS2_uc011czu.1_Missense_Mutation_p.H11Y	NM_012208	NP_036340	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2 precursor	152					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAACGTTATCATGTTGGAAA	0.473													39	77					0	0	0.00148497	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209499	140209499	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140209499C>T	uc003lho.2	+	1	1850	c.1823C>T	c.(1822-1824)TCG>TTG	p.S608L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.S608L	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	608	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGCTTTCGTATGAGCTG	0.662													10	30					0	0	0.000442599	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222071	140222071	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140222071C>T	uc003lhs.2	+	1	1165	c.1165C>T	c.(1165-1167)CTG>TTG	p.L389L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.L389L	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	389	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCTGCTCCCTGATGCCCCA	0.557													65	91					0	0	0.000781405	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236204	140236204	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140236204C>T	uc003lhx.2	+	1	571	c.571C>T	c.(571-573)CCA>TCA	p.P191S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.P191S|PCDHA10_uc011dad.1_Missense_Mutation_p.P191S	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	191	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACAAATTCCCAGTGCTTGT	0.403													37	45					0	0	0.000814825	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236476	140236476	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140236476C>T	uc003lhx.2	+	1	843	c.843C>T	c.(841-843)AGC>AGT	p.S281S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Silent_p.S281S|PCDHA10_uc011dad.1_Silent_p.S281S	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	281	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCATTTAGCTCTTTGGTCC	0.358													22	39					0	0	0.000375601	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432091	140432091	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140432091G>A	uc003lik.1	+	1	1113	c.1036G>A	c.(1036-1038)GAA>AAA	p.E346K		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	346	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATCCTCCCGAAGTGATGGT	0.517													23	41					0	0	0.00229938	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502954	140502954	+	Silent	SNP	C	T	T	rs148427211		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140502954C>T	uc003lip.1	+	1	1374	c.1374C>T	c.(1372-1374)TTC>TTT	p.F458F		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	458	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.627													21	53					0	0	0.0024448	0	0
PCDHB5	26167	broad.mit.edu	37	5	140517259	140517259	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140517259A>T	uc003liq.2	+	1	2460	c.2243A>T	c.(2242-2244)TAC>TTC	p.Y748F		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	748	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCAGAGCTACCACTACGAG	0.632													53	95					0	0	0.000781405	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552862	140552862	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140552862G>A	uc003lit.2	+	1	620	c.446G>A	c.(445-447)GGG>GAG	p.G149E		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	149	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCACTCCAGGGGCGGCATTT	0.438													24	47					0	0	0.000375601	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553921	140553921	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140553921C>T	uc003lit.2	+	1	1679	c.1505C>T	c.(1504-1506)TCC>TTC	p.S502F		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	502	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCTCGCCTCCCTGGTCTCC	0.672													33	44					0	0	0.00128727	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140718655	140718655	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140718655C>T	uc003ljk.1	+	1	302	c.117C>T	c.(115-117)ATC>ATT	p.I39I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Silent_p.I39I	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	39	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGAAGAGATCGACAGAGGCT	0.607											OREG0016854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	36					0	0	0.000566183	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750199	140750199	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140750199G>A	uc003ljw.1	+	1	238	c.238G>A	c.(238-240)GAA>AAA	p.E80K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.E80K	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	80	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGAGCCCCGAAAATGGGAA	0.502													80	152					0	0	0.000781405	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769813	140769813	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140769813C>T	uc003lkc.1	+	1	2362	c.2362C>T	c.(2362-2364)CCA>TCA	p.P788S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.P788S	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	788	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCTTATTTCCACTTTGTAA	0.383													46	118					0	0	0.000680045	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774627	140774627	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140774627C>T	uc003lkd.1	+	1	3145	c.2247C>T	c.(2245-2247)TTC>TTT	p.F749F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.F749F	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	749	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACAGGCTTTCCTGCAGACCT	0.582													34	23					0	0	0.00209593	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140803134	140803134	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140803134C>T	uc003lkq.1	+	1	2598	c.2340C>T	c.(2338-2340)CTC>CTT	p.L780L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Silent_p.L780L|PCDHGA11_uc003lkp.1_Intron|PCDHGB8P_uc011daz.1_5'Flank	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	780	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGACACGCTCATCAGCCAGG	0.502													15	31					0	0	0.000308642	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811671	140811671	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:140811671C>T	uc003lkt.1	+	1	1514	c.1345C>T	c.(1345-1347)CCG>TCG	p.P449S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.P449S	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	449	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACGACAACCCGCCGGTCTT	0.582													8	39					0	0	0.000673444	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147019205	147019205	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:147019205C>T	uc003loq.1	-	10	1902	c.1520G>A	c.(1519-1521)CGA>CAA	p.R507Q	JAKMIP2_uc011dbx.1_Missense_Mutation_p.R465Q|JAKMIP2_uc003lor.1_Missense_Mutation_p.R507Q|uc003lop.1_Intron|JAKMIP2_uc010jgo.1_Missense_Mutation_p.R507Q	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	507	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTGGCTTCTCGTTCAGCGTC	0.448													131	237					0	0	0.000781405	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040616	147040616	+	Silent	SNP	G	A	A	rs149958309		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:147040616G>A	uc003loq.1	-	3	904	c.522C>T	c.(520-522)ATC>ATT	p.I174I	JAKMIP2_uc011dbx.1_Silent_p.I132I|JAKMIP2_uc003lor.1_Silent_p.I174I|uc003lop.1_3'UTR|JAKMIP2_uc010jgo.1_Silent_p.I174I	NM_014790	NP_055605	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein	174	Potential.					Golgi apparatus				large_intestine(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATCTGCTTGGATCATATTGC	0.522													73	112					0	0	0.000781405	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148685890	148685890	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:148685890C>T	uc003lqh.2	+	6	589	c.458C>T	c.(457-459)TCG>TTG	p.S153L	AFAP1L1_uc003lqg.3_Missense_Mutation_p.S153L|AFAP1L1_uc010jgy.2_Missense_Mutation_p.S153L	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	153							protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTCACACTCGATTGTGGAT	0.582													5	11					0	0	0.000602214	0	0
RBM22	55696	broad.mit.edu	37	5	150071404	150071404	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:150071404G>A	uc003lst.2	-	11	1294	c.1172C>T	c.(1171-1173)CCT>CTT	p.P391L		NM_018047	NP_060517	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	391	Pro-rich.				protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding				0		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CATGAAAGGAGGGGGTGGTCC	0.522													22	43					0	0	0.000586117	0	0
FAT2	2196	broad.mit.edu	37	5	150885259	150885259	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:150885259C>T	uc003lue.3	-	23	12930	c.12917G>A	c.(12916-12918)GGG>GAG	p.G4306E	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.G913E	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	4306	Cytoplasmic (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATAAGAGGGCCCAGCTCGGCT	0.672													9	23					0	0	0.000442599	0	0
HAND1	9421	broad.mit.edu	37	5	153855395	153855395	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:153855395G>A	uc003lvn.2	-	2	875	c.619C>T	c.(619-621)CAA>TAA	p.Q207*		NM_004821	NP_004812	O96004	HAND1_HUMAN	basic helix-loop-helix transcription factor	207					angiogenesis|cardiac left ventricle formation|cardiac right ventricle formation|cardiac septum morphogenesis|heart looping|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trophectodermal cell differentiation|ventricular cardiac muscle tissue morphogenesis	cytoplasm|nucleolus|nucleoplasm	bHLH transcription factor binding|DNA binding|protein homodimerization activity|transcription coactivator activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GCCCAGACTTGCTGCGGCCAG	0.637													14	26					0	0	0.000566183	0	0
LARP1	23367	broad.mit.edu	37	5	154190829	154190829	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:154190829C>T	uc003lvp.2	+	17	3295	c.2866C>T	c.(2866-2868)CGA>TGA	p.R956*	LARP1_uc003lvo.2_Nonsense_Mutation_p.R879*	NM_033551	NP_291029	Q6PKG0	LARP1_HUMAN	la related protein isoform 2	956							protein binding|RNA binding			ovary(2)|pancreas(1)|skin(1)	4	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTGCCTTTTTCGATACTACAG	0.338													19	34					0	0	0.00121646	0	0
ITK	3702	broad.mit.edu	37	5	156641224	156641224	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:156641224G>T	uc003lwo.1	+	4	430	c.348G>T	c.(346-348)TTG>TTT	p.L116F		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	116	Btk-type.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATAACAGTTTGGTGCCTAAAT	0.443			T	SYK	peripheral T-cell lymphoma								10	327					0.000978159	0.00402107	0.000978159	1	0
C5orf54	63920	broad.mit.edu	37	5	159822450	159822450	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:159822450G>A	uc003lye.1	-	2	512	c.48C>T	c.(46-48)TTC>TTT	p.F16F	C5orf54_uc003lyf.1_Silent_p.F16F	NM_022090	NP_071373	Q8IZ13	CE054_HUMAN	transposon-derived Buster3 transposase-like	16										pancreas(1)	1						ttgtacaggtgaaccagtagc	0													29	79					0	0	0.001512	0	0
GABRB2	2561	broad.mit.edu	37	5	160721128	160721128	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:160721128G>A	uc003lys.1	-	11	1717	c.1499C>T	c.(1498-1500)TCC>TTC	p.S500F	GABRB2_uc011deh.1_Missense_Mutation_p.S301F|GABRB2_uc003lyr.1_Missense_Mutation_p.S462F|GABRB2_uc003lyt.1_Missense_Mutation_p.S462F|GABRB2_uc010jiu.1_Missense_Mutation_p.S399F	NM_021911	NP_068711	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	500	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity				0	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	GTTGAAGAAGGAAAAAACCAC	0.473													20	22					0	0	0.00188189	0	0
GABRG2	2566	broad.mit.edu	37	5	161569269	161569269	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:161569269C>T	uc003lyz.3	+	7	1227	c.869C>T	c.(868-870)TCC>TTC	p.S290F	GABRG2_uc010jjc.2_Missense_Mutation_p.S330F|GABRG2_uc003lyy.3_Missense_Mutation_p.S290F|GABRG2_uc011dej.1_Missense_Mutation_p.S195F	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	290	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GTCGTCCTATCCTGGGTGTCT	0.428													31	38					0	0	0.001512	0	0
GABRG2	2566	broad.mit.edu	37	5	161580099	161580099	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:161580099G>A	uc003lyz.3	+	9	1487	c.1129G>A	c.(1129-1131)GCC>ACC	p.A377T	GABRG2_uc010jjc.2_Missense_Mutation_p.A425T|GABRG2_uc003lyy.3_Missense_Mutation_p.A385T|GABRG2_uc011dej.1_Missense_Mutation_p.A282T	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	377	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CTCGTCCCAGGCCCCTACCAT	0.458													18	38					0	0	0.000958276	0	0
FOXI1	2299	broad.mit.edu	37	5	169535126	169535126	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:169535126G>A	uc003mai.3	+	2	693	c.648G>A	c.(646-648)AGG>AGA	p.R216R	FOXI1_uc003maj.3_Intron	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	216	Fork-head.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCAGGAAAAGGAAGAGAAAAT	0.498									Pendred_syndrome				26	44					0	0	0.000878237	0	0
GABRP	2568	broad.mit.edu	37	5	170239061	170239061	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:170239061C>T	uc003mau.2	+	10	1320	c.1122C>T	c.(1120-1122)TCC>TCT	p.S374S	GABRP_uc011dev.1_3'UTR	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	374	Cytoplasmic (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTGAAATTTCCAGCGACAACG	0.403													21	44					0	0	0.00121646	0	0
RANBP17	64901	broad.mit.edu	37	5	170667979	170667979	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr5:170667979C>T	uc003mba.2	+	23	2486	c.2470C>T	c.(2470-2472)CCA>TCA	p.P824S	RANBP17_uc003mbb.2_Missense_Mutation_p.P149S|RANBP17_uc003mbd.2_Missense_Mutation_p.P187S|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	824					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCAGATTTATCCAATGAAACT	0.418			T	TRD@	ALL								59	93					0	0	0.000781405	0	0
HIVEP1	3096	broad.mit.edu	37	6	12123591	12123591	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:12123591G>A	uc003nac.2	+	4	3742	c.3563G>A	c.(3562-3564)CGG>CAG	p.R1188Q	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1188					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CACCCTTCTCGGGACGGGTCT	0.507													18	27					0	0	0.00152264	0	0
TDP2	51567	broad.mit.edu	37	6	24653351	24653351	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:24653351T>C	uc003nej.2	-	6	692	c.667A>G	c.(667-669)ATG>GTG	p.M223V	TDP2_uc003nei.2_Missense_Mutation_p.M111V|TDP2_uc010jpu.1_Missense_Mutation_p.M223V	NM_016614	NP_057698	O95551	TYDP2_HUMAN	TRAF and TNF receptor-associated protein	223					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			ovary(1)|lung(1)	2						TGGGATGTCATAAGGCAAAGC	0.408								Direct_reversal_of_damage|Editing_and_processing_nucleases					108	164					0	0	0.000781405	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26108317	26108317	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:26108317G>A	uc003ngj.2	-	1	48	c.5C>T	c.(4-6)TCT>TTT	p.S2F		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	2					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CACGGTTTCAGACATAACAAC	0.542													11	26					0	0	0.00136819	0	0
OR2B3	442184	broad.mit.edu	37	6	29054546	29054546	+	Silent	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:29054546A>T	uc003nlx.2	-	1	545	c.480T>A	c.(478-480)TCT>TCA	p.S160S		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						GAGTCAAGGAAGACTGCAGCA	0.498													14	30					0	0	0.00185496	0	0
GABBR1	2550	broad.mit.edu	37	6	29581119	29581119	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:29581119G>A	uc003nmt.3	-	12	1803	c.1467C>T	c.(1465-1467)GGC>GGT	p.G489G	GABBR1_uc003nmp.3_Silent_p.G372G|GABBR1_uc003nms.3_Silent_p.G372G|GABBR1_uc003nmu.3_Silent_p.G427G|GABBR1_uc011dlr.1_Silent_p.G312G|GABBR1_uc011dls.1_Silent_p.G489G	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	489	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	CACCAGAACGGCCGCCTCCTC	0.577													37	60					0	0	0.000953801	0	0
ZFP57	346171	broad.mit.edu	37	6	29640508	29640508	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:29640508C>T	uc011dlw.1	-	4	1531	c.1380G>A	c.(1378-1380)AGG>AGA	p.R460R	ZFP57_uc003nnl.3_Silent_p.R440R	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	376	C2H2-type 7; degenerate.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CTTTATAGCCCCTCCAGTGAT	0.557													21	47					0	0	0.00152264	0	0
DDR1	780	broad.mit.edu	37	6	30860301	30860301	+	Missense_Mutation	SNP	G	A	A	rs147485952		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:30860301G>A	uc003nrr.2	+	9	1340	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K	DDR1_uc010jse.2_Missense_Mutation_p.E361K|DDR1_uc003nrq.2_Missense_Mutation_p.E361K|DDR1_uc003nrs.2_Missense_Mutation_p.E361K|DDR1_uc003nrt.2_Missense_Mutation_p.E361K|DDR1_uc011dms.1_Missense_Mutation_p.E379K|DDR1_uc003nru.2_Missense_Mutation_p.E361K|DDR1_uc003nrv.2_Missense_Mutation_p.E361K|DDR1_uc003nrw.1_Missense_Mutation_p.E160K|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	361	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	ACTCTTCAGCGAAATCTCCTT	0.567													20	50					0	0	0.00229938	0	0
MCCD1	401250	broad.mit.edu	37	6	31496962	31496962	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:31496962G>A	uc003ntp.1	+	1	224	c.171G>A	c.(169-171)AGG>AGA	p.R57R		NM_001011700	NP_001011700	P59942	MCCD1_HUMAN	mitochondrial coiled-coil domain 1 precursor	57						mitochondrion					0						CCCCTCCCAGGGTAAGTGGCA	0.567													11	29					0	0	0.000978159	0	0
NEU1	4758	broad.mit.edu	37	6	31829067	31829067	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:31829067C>A	uc003nxq.3	-	3	669	c.513G>T	c.(511-513)TTG>TTT	p.L171F	NEU1_uc010jtg.2_RNA|NEU1_uc003nxr.3_RNA|NEU1_uc010jth.2_Missense_Mutation_p.L2F|NEU1_uc003nxs.3_Missense_Mutation_p.L171F	NM_000434	NP_000425	Q99519	NEUR1_HUMAN	neuraminidase precursor	171						cytoplasmic membrane-bounded vesicle|lysosomal lumen|lysosomal membrane|plasma membrane	exo-alpha-sialidase activity|protein binding			ovary(1)	1					Oseltamivir(DB00198)|Zanamivir(DB00558)	TGCTCCATACCAACATGGTAG	0.537													9	299					3.86212e-05	0.000159626	0.000673444	1	0
EHMT2	10919	broad.mit.edu	37	6	31848861	31848862	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:31848861_31848862CC>AA	uc003nxz.1	-	26	3215_3216	c.3205_3206GG>TT	c.(3205-3207)GGG>TTG	p.G1069L	EHMT2_uc003nxv.1_Missense_Mutation_p.G108L|EHMT2_uc003nxw.1_Missense_Mutation_p.G108L|EHMT2_uc003nxx.1_Missense_Mutation_p.G267L|EHMT2_uc003nxy.1_Missense_Mutation_p.G867L|EHMT2_uc011don.1_Missense_Mutation_p.G1092L|EHMT2_uc003nya.1_Missense_Mutation_p.G1035L|SLC44A4_uc010jti.2_5'Flank|SLC44A4_uc011dom.1_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	1069	SET.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			ovary(1)	1						GATCAGCTCCCCGACATACCTG	0.535													8	202					0	0	6.4e-05	0	0
TNXB	7148	broad.mit.edu	37	6	32017250	32017250	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:32017250G>A	uc003nzl.2	-	28	9750	c.9548C>T	c.(9547-9549)TCC>TTC	p.S3183F	TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3230	Fibronectin type-III 24.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GACGGTCCAGGAGAGGCTCAG	0.682													125	194					0	0	0.000781405	0	0
TNXB	7148	broad.mit.edu	37	6	32038104	32038104	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:32038104G>A	uc003nzl.2	-	14	5280	c.5078C>T	c.(5077-5079)TCC>TTC	p.S1693F		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1775	Fibronectin type-III 10.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AACCGTCCAGGAGAGGCGCAG	0.657													58	113					0	0	0.000781405	0	0
TNXB	7148	broad.mit.edu	37	6	32063453	32063453	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:32063453C>T	uc003nzl.2	-	3	2379	c.2177G>A	c.(2176-2178)CGA>CAA	p.R726Q		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	726	EGF-like 19.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						ACACTCTCCTCGGCCACGGCA	0.637													83	135					0	0	0.000781405	0	0
PACSIN1	29993	broad.mit.edu	37	6	34499429	34499429	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:34499429G>A	uc003ojo.2	+	9	1296	c.1090G>A	c.(1090-1092)GAG>AAG	p.E364K	PACSIN1_uc003ojp.2_Missense_Mutation_p.E364K	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	364					endocytosis		protein kinase activity				0						GTCAGACGACGAGAGTGGGAA	0.622													41	85					0	0	0.000781405	0	0
SCUBE3	222663	broad.mit.edu	37	6	35208186	35208186	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:35208186C>T	uc003okf.1	+	9	994	c.988C>T	c.(988-990)CAC>TAC	p.H330Y	SCUBE3_uc003okg.1_Missense_Mutation_p.H329Y|SCUBE3_uc003okh.1_Missense_Mutation_p.H217Y	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	330	EGF-like 8; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AACCTGTGACCACATATGTGT	0.488													14	31					0	0	0.000566183	0	0
C6orf127	340204	broad.mit.edu	37	6	35754864	35754864	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:35754864G>A	uc003old.3	+	2	246	c.189G>A	c.(187-189)GAG>GAA	p.E63E		NM_001010886	NP_001010886	A2RUU4	CF127_HUMAN	hypothetical protein LOC340204 precursor	63					digestion|lipid catabolic process	extracellular region	enzyme activator activity			skin(1)	1						ACTGCGCGGAGAAGGGGTCCG	0.662													8	47					0	0	0.000442599	0	0
DNAH8	1769	broad.mit.edu	37	6	38843575	38843576	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:38843575_38843576CC>TT	uc003ooe.1	+	51	7778_7779	c.7178_7179CC>TT	c.(7177-7179)ACC>ATT	p.T2393I		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TCAAATCAAACCATGTATGAGT	0.356													15	35					0	0	6.4e-05	0	0
DNAH8	1769	broad.mit.edu	37	6	38885135	38885135	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:38885135G>A	uc003ooe.1	+	67	10210	c.9610G>A	c.(9610-9612)GAT>AAT	p.D3204N	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGTTACTATGGATCCAGAAAA	0.398													27	44					0	0	0.000878237	0	0
GLP1R	2740	broad.mit.edu	37	6	39040774	39040774	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:39040774G>A	uc003ooj.3	+	6	706	c.646G>A	c.(646-648)GGG>AGG	p.G216R	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	216	Extracellular (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	CCAGTGGGATGGGCTCCTCTC	0.617													14	35					0	0	0.00074312	0	0
LRFN2	57497	broad.mit.edu	37	6	40400449	40400449	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:40400449T>A	uc003oph.1	-	2	869	c.404A>T	c.(403-405)CAG>CTG	p.Q135L		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	135	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCCGCCCAGCTGGTTGTTGTT	0.597													16	20					0	0	0.000422831	0	0
TTBK1	84630	broad.mit.edu	37	6	43227423	43227423	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:43227423G>A	uc003ouq.1	+	12	1682	c.1403G>A	c.(1402-1404)CGA>CAA	p.R468Q		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	468						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GCGGACGGGCGAGTGGAGCTA	0.657													4	4					0	0	0.00116845	0	0
SLC22A7	10864	broad.mit.edu	37	6	43267668	43267668	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:43267668G>A	uc003out.2	+	5	790	c.691G>A	c.(691-693)GTG>ATG	p.V231M	SLC22A7_uc010jyl.1_Missense_Mutation_p.V232M|SLC22A7_uc003ous.2_Missense_Mutation_p.V229M	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	231						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GCACCGCACCGTGGCTGGAGT	0.607													27	43					0	0	0.00127121	0	0
TMEM63B	55362	broad.mit.edu	37	6	44120422	44120422	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:44120422C>T	uc003owr.2	+	20	1993	c.1929C>T	c.(1927-1929)ATC>ATT	p.I643I	TMEM63B_uc003ows.2_Silent_p.I546I|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	643	Helical; (Potential).					integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CCTGCCCCATCATCGTGCCCT	0.647											OREG0017465	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	21					0	0	0.00121646	0	0
TCTE1	202500	broad.mit.edu	37	6	44253959	44253959	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:44253959G>A	uc003oxi.2	-	3	744	c.588C>T	c.(586-588)TTC>TTT	p.F196F	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	196										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCGGCGGAAGGAACTGATCGA	0.647													18	30					0	0	0.00121646	0	0
GPR116	221395	broad.mit.edu	37	6	46874485	46874485	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:46874485C>T	uc003oyo.3	-	2	304	c.15G>A	c.(13-15)AGG>AGA	p.R5R	GPR116_uc003oyp.3_Silent_p.R5R|GPR116_uc003oyq.3_Silent_p.R5R|GPR116_uc003oyr.2_Silent_p.R5R|uc003oys.2_Intron	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	5					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			AAGTGGTTCTCCTTGGGGATT	0.358													32	44					0	0	0.00058488	0	0
OPN5	221391	broad.mit.edu	37	6	47754326	47754326	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:47754326A>C	uc003ozc.2	+	2	211	c.206A>C	c.(205-207)GAA>GCA	p.E69A	OPN5_uc003ozd.2_5'Flank	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	69	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						AGACCCGCTGAAATAATGACT	0.383													17	47					0	0	0.000566183	0	0
GCM1	8521	broad.mit.edu	37	6	52993715	52993716	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:52993715_52993716CC>TT	uc003pbp.2	-	6	808_809	c.599_600GG>AA	c.(598-600)GGG>GAA	p.G200E		NM_003643	NP_003634	Q9NP62	GCM1_HUMAN	glial cells missing homolog a	200						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)	1	Lung NSC(77;0.0755)					AAGGTAAACTCCCCTGACTTTG	0.431													26	62					0	0	6.4e-05	0	0
FAM83B	222584	broad.mit.edu	37	6	54804969	54804969	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:54804969C>T	uc003pck.2	+	5	1316	c.1200C>T	c.(1198-1200)CTC>CTT	p.L400L		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	400										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TGCCATACCTCCTGCTTAATA	0.443													35	51					0	0	0.00128727	0	0
FAM83B	222584	broad.mit.edu	37	6	54806277	54806277	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:54806277G>A	uc003pck.2	+	5	2624	c.2508G>A	c.(2506-2508)TCG>TCA	p.S836S		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	836	Poly-Ser.									ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CTTCCTCATCGAATTCTCAAG	0.388													8	20					0	0	0.000157383	0	0
GFRAL	389400	broad.mit.edu	37	6	55216368	55216368	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:55216368G>A	uc003pcm.1	+	5	774	c.688G>A	c.(688-690)GAT>AAT	p.D230N		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	230	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGCCAAAATGATGAATTATG	0.423													11	36					0	0	0.000978159	0	0
GFRAL	389400	broad.mit.edu	37	6	55223744	55223744	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:55223744G>A	uc003pcm.1	+	6	846	c.760G>A	c.(760-762)GAA>AAA	p.E254K		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	254	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAAGTGCCATGAAGATGAGAA	0.408													25	70					0	0	0.00106085	0	0
KIAA1586	57691	broad.mit.edu	37	6	56919312	56919312	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:56919312G>A	uc003pdj.2	+	4	2185	c.2015G>A	c.(2014-2016)CGG>CAG	p.R672Q	KIAA1586_uc011dxm.1_Missense_Mutation_p.R645Q	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	672							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AATGATTTTCGGGAATTTGTA	0.269													9	27					0	0	0.000274275	0	0
PRIM2	5558	broad.mit.edu	37	6	57512661	57512661	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:57512661G>A	uc003pdx.2	+	15	1576	c.1489G>A	c.(1489-1491)GAT>AAT	p.D497N		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	497					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TCTGGAAATGGATATGGAAGG	0.403													67	446					0	0	0.000781405	0	0
MCART3P	442229	broad.mit.edu	37	6	66499092	66499092	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:66499092G>A	uc011dxw.1	+	1		c.1321G>A				NR_026540				Homo sapiens mitochondrial carrier triple repeat 3 pseudogene, mRNA (cDNA clone IMAGE:4821649).												0						GAACGGGACAGAAAACTGATA	0.368													11	19					0	0	0.000978159	0	0
BAI3	577	broad.mit.edu	37	6	70070771	70070771	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:70070771G>A	uc003pev.3	+	29	4054	c.3606G>A	c.(3604-3606)AAG>AAA	p.K1202K	BAI3_uc010kak.2_Silent_p.K1202K|BAI3_uc011dxx.1_Silent_p.K408K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1202	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TTCTTCATAAGGATATTGGTC	0.353													17	42					0	0	0.000958276	0	0
COL19A1	1310	broad.mit.edu	37	6	70672762	70672762	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:70672762G>A	uc003pfc.1	+	11	1143	c.1026G>A	c.(1024-1026)AAG>AAA	p.K342K	COL19A1_uc010kam.1_Silent_p.K238K	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	342	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						CTGGTGAAAAGGTAAATATCT	0.303													18	28					0	0	0.00152264	0	0
COL9A1	1297	broad.mit.edu	37	6	71004230	71004230	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:71004230G>A	uc003pfg.3	-	5	495	c.336C>T	c.(334-336)TCC>TCT	p.S112S		NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	112	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						TCGTCAAGAAGGAGTATTCTT	0.393													42	84					0	0	0.000781405	0	0
C6orf150	115004	broad.mit.edu	37	6	74155359	74155359	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:74155359G>A	uc003pgx.1	-	2	908	c.769C>T	c.(769-771)CCG>TCG	p.P257S		NM_138441	NP_612450	Q8N884	M21D1_HUMAN	hypothetical protein LOC115004	257											0						TTTTCTTTCGGATTTCTTTTA	0.313													32	39					0	0	0.00209593	0	0
NT5E	4907	broad.mit.edu	37	6	86197192	86197192	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:86197192G>A	uc003pko.3	+	5	1645	c.1089G>A	c.(1087-1089)CTG>CTA	p.L363L	NT5E_uc010kbr.2_Silent_p.L363L	NM_002526	NP_002517	P21589	5NTD_HUMAN	5' nucleotidase, ecto precursor	363					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			ovary(3)|central_nervous_system(1)	4		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	TGGGCAACCTGATTTGTGATG	0.343													57	88					0	0	0.000781405	0	0
ZNF292	23036	broad.mit.edu	37	6	87964629	87964629	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:87964629T>C	uc003plm.3	+	8	1323	c.1282T>C	c.(1282-1284)TTA>CTA	p.L428L		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACCAAATTCTTTACGCTGTGA	0.383													20	30					0	0	0.00152264	0	0
MDN1	23195	broad.mit.edu	37	6	90380733	90380733	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:90380733C>T	uc003pnn.1	-	83	13977	c.13861G>A	c.(13861-13863)GTC>ATC	p.V4621I		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4621					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AAGAAGAGGACGAGGTCTGAG	0.522													21	52					0	0	0.00121646	0	0
MDN1	23195	broad.mit.edu	37	6	90385895	90385895	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:90385895C>T	uc003pnn.1	-	77	12687	c.12571G>A	c.(12571-12573)GGA>AGA	p.G4191R		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4191					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTCTGGCATCCATCCCATGAA	0.448													27	51					0	0	0.001512	0	0
FIG4	9896	broad.mit.edu	37	6	110110840	110110840	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:110110840A>C	uc003ptt.2	+	19	2355	c.2140A>C	c.(2140-2142)ACT>CCT	p.T714P	FIG4_uc011eau.1_Missense_Mutation_p.T437P	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	714					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		AAGTCCATTTACTGTGCGTAA	0.338													24	54					0	0	0.00178596	0	0
DDO	8528	broad.mit.edu	37	6	110734509	110734509	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:110734509G>A	uc003puc.2	-	2	245	c.241C>T	c.(241-243)CCT>TCT	p.P81S	C6orf186_uc003pub.2_5'Flank|DDO_uc003pud.2_Missense_Mutation_p.P81S	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	53					aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		TAAGTGTGAGGAATAAGCATT	0.443													32	40					0	0	0.00058488	0	0
CDK19	23097	broad.mit.edu	37	6	110988704	110988704	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:110988704G>A	uc003puh.1	-	4	462	c.389C>T	c.(388-390)TCC>TTC	p.S130F	CDK19_uc003pui.1_Missense_Mutation_p.S70F	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	130	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GTAAAGTAAGGATTTAACCAT	0.303													33	43					0	0	0.000953801	0	0
TSPYL4	23270	broad.mit.edu	37	6	116574216	116574216	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:116574216G>A	uc003pwn.2	-	1	1046	c.956C>T	c.(955-957)TCC>TTC	p.S319F	DSE_uc011ebf.1_5'Flank|TSPYL4_uc011ebe.1_Missense_Mutation_p.S147F|uc003pwo.1_5'Flank	NM_021648	NP_067680	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	319					nucleosome assembly	nucleus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		CCGGCCAGAGGATCTGCGTTC	0.542													14	32					0	0	0.000958276	0	0
GPRC6A	222545	broad.mit.edu	37	6	117114369	117114369	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:117114369G>A	uc003pxj.1	-	6	1739	c.1717C>T	c.(1717-1719)CCT>TCT	p.P573S	GPRC6A_uc003pxk.1_Missense_Mutation_p.P398S|GPRC6A_uc003pxl.1_Missense_Mutation_p.P502S	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	573	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CTCCTAACAGGGGCCCAGTGA	0.438													9	12					0	0	0.000442599	0	0
GPRC6A	222545	broad.mit.edu	37	6	117116901	117116901	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:117116901G>A	uc003pxj.1	-	5	1668	c.1646C>T	c.(1645-1647)CCT>CTT	p.P549L	GPRC6A_uc003pxk.1_Missense_Mutation_p.P374L|GPRC6A_uc003pxl.1_Missense_Mutation_p.P478L	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	549	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATGATTTTCAGGACAGTTCTG	0.358													24	47					0	0	0.000720815	0	0
MAN1A1	4121	broad.mit.edu	37	6	119569520	119569520	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:119569520C>T	uc003pym.1	-	6	1340	c.898_splice	c.e6-1	p.I300_splice	MAN1A1_uc010kei.1_Splice_Site_p.I323_splice	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1						post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TTCGAAAAATCTGAAAAGTCA	0.338													15	18					0	0	0.000422831	0	0
HEY2	23493	broad.mit.edu	37	6	126080650	126080650	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:126080650G>A	uc003qad.2	+	5	907	c.716G>A	c.(715-717)CGA>CAA	p.R239Q	HEY2_uc011ebr.1_Missense_Mutation_p.R193Q	NM_012259	NP_036391	Q9UBP5	HEY2_HUMAN	hairy/enhancer-of-split related with YRPW motif	239					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		TCAGCCCTCCGAATGCCATCC	0.657													55	105					0	0	0.000781405	0	0
PTPRK	5796	broad.mit.edu	37	6	128400043	128400043	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:128400043C>T	uc003qbk.2	-	11	2165	c.1798G>A	c.(1798-1800)GAA>AAA	p.E600K	PTPRK_uc003qbj.2_Missense_Mutation_p.E600K|PTPRK_uc010kfc.2_Missense_Mutation_p.E600K|PTPRK_uc011ebu.1_Missense_Mutation_p.E600K|PTPRK_uc003qbl.1_Missense_Mutation_p.E470K|PTPRK_uc011ebv.1_Missense_Mutation_p.E600K	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	600	Extracellular (Potential).|Fibronectin type-III 4.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCAACTCCTTCATAGTCAGGT	0.383													45	67					0	0	0.000781405	0	0
LAMA2	3908	broad.mit.edu	37	6	129635813	129635813	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:129635813G>A	uc003qbn.2	+	24	3530	c.3425G>A	c.(3424-3426)GGC>GAC	p.G1142D	LAMA2_uc003qbo.2_Missense_Mutation_p.G1142D	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1142	Laminin EGF-like 13.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AATGTGGAAGGCATCCACTGT	0.512													12	28					0	0	0.00185496	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762228	130762228	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:130762228C>T	uc003qca.2	+	3	1532	c.661C>T	c.(661-663)CGA>TGA	p.R221*	TMEM200A_uc010kfh.2_Nonsense_Mutation_p.R221*|TMEM200A_uc010kfi.2_Nonsense_Mutation_p.R221*|TMEM200A_uc003qcb.2_Nonsense_Mutation_p.R221*	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	221	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GAGCAGTTTTCGAATGGACAG	0.478													16	33					0	0	0.000422831	0	0
EPB41L2	2037	broad.mit.edu	37	6	131277475	131277475	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:131277475G>A	uc003qch.2	-	2	333	c.151C>T	c.(151-153)CCT>TCT	p.P51S	EPB41L2_uc003qcg.1_Missense_Mutation_p.P51S|EPB41L2_uc011eby.1_Missense_Mutation_p.P51S|EPB41L2_uc003qci.2_Missense_Mutation_p.P51S|EPB41L2_uc010kfk.2_Missense_Mutation_p.P51S|EPB41L2_uc010kfl.1_Missense_Mutation_p.P51S	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	51					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TCAGCTGCAGGAGGTGGCTGG	0.453													40	59					0	0	0.00128727	0	0
EYA4	2070	broad.mit.edu	37	6	133834096	133834096	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:133834096G>A	uc003qec.3	+	16	1879	c.1421G>A	c.(1420-1422)GGG>GAG	p.G474E	EYA4_uc011ecq.1_Missense_Mutation_p.G420E|EYA4_uc011ecr.1_Missense_Mutation_p.G426E|EYA4_uc003qed.3_Missense_Mutation_p.G474E|EYA4_uc003qee.3_Missense_Mutation_p.G451E|EYA4_uc011ecs.1_Missense_Mutation_p.G480E|uc003qeg.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	474					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GTAAGAGGAGGGGTTGACTGG	0.413													20	31					0	0	0.00152264	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597503	136597503	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:136597503T>C	uc003qgx.1	-	5	1413	c.1160A>G	c.(1159-1161)AAA>AGA	p.K387R	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Missense_Mutation_p.K385R|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.K385R	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	387					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCCAGACTCTTTATCACTGAA	0.438													49	237					0	0	0.000781405	0	0
HECA	51696	broad.mit.edu	37	6	139498230	139498230	+	Silent	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:139498230C>A	uc003qin.2	+	4	1905	c.1620C>A	c.(1618-1620)CTC>CTA	p.L540L		NM_016217	NP_057301	Q9UBI9	HDC_HUMAN	headcase	540					respiratory tube development						0				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		TCAAAGTTCTCGAAGCTTATT	0.368													6	15					3.59834e-05	0.000148954	0.00116845	1	0
NMBR	4829	broad.mit.edu	37	6	142409714	142409714	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:142409714C>T	uc003qiu.2	-	1	223	c.82G>A	c.(82-84)GAT>AAT	p.D28N		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	28	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GGCAGGAAATCCCTTTCCCAC	0.607													13	23					0	0	0.000219431	0	0
PHACTR2	9749	broad.mit.edu	37	6	144070141	144070141	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:144070141C>T	uc003qjq.3	+	3	331	c.201C>T	c.(199-201)TCC>TCT	p.S67S	PHACTR2_uc010khh.2_Silent_p.S67S|PHACTR2_uc010khi.2_Silent_p.S78S|PHACTR2_uc003qjr.3_Silent_p.S78S	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	67	RPEL 1.						actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		GGAAGATATCCACACGACAAA	0.333													10	20					0	0	0.000673444	0	0
NUP43	348995	broad.mit.edu	37	6	150059891	150059891	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:150059891G>A	uc003qmz.2	-	5	583	c.526C>T	c.(526-528)CAT>TAT	p.H176Y	NUP43_uc003qmx.3_5'Flank|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Intron	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	176	WD 4.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		GTTACAGCATGGAGTGTACTA	0.343													38	74					0	0	0.00195071	0	0
PNLDC1	154197	broad.mit.edu	37	6	160239996	160239996	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:160239996T>A	uc003qsx.1	+	17	1414	c.1243T>A	c.(1243-1245)TAT>AAT	p.Y415N	PNLDC1_uc003qsy.1_Missense_Mutation_p.Y426N	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	415	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TGGTCCAGATTATCCCAGTAT	0.443													30	54					0	0	0.000692331	0	0
PLG	5340	broad.mit.edu	37	6	161139332	161139332	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:161139332C>T	uc003qtm.3	+	8	857	c.794C>T	c.(793-795)CCT>CTT	p.P265L		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	265					extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CAAGCAACACCTCCACCATCT	0.343													29	52					0	0	0.00178596	0	0
QKI	9444	broad.mit.edu	37	6	163984665	163984665	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:163984665T>A	uc003qui.2	+	6	1399	c.848T>A	c.(847-849)TTA>TAA	p.L283*	QKI_uc003que.2_Nonsense_Mutation_p.L283*|QKI_uc003quf.2_Nonsense_Mutation_p.L283*|QKI_uc003qug.2_Nonsense_Mutation_p.L283*|QKI_uc003quh.2_Nonsense_Mutation_p.L275*|QKI_uc003quj.2_Nonsense_Mutation_p.L275*	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	283					mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		GAAGCTGGTTTAATCTATACA	0.463													31	34					0	0	0.001512	0	0
TTLL2	83887	broad.mit.edu	37	6	167755067	167755067	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:167755067T>A	uc003qvs.1	+	3	1767	c.1679T>A	c.(1678-1680)TTT>TAT	p.F560Y	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	560					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GTTCTTGTTTTTCCTTTCAAT	0.458													18	39					0	0	0.000566183	0	0
SUN1	23353	broad.mit.edu	37	7	872193	872193	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:872193C>T	uc011jvp.1	+	2	111	c.32C>T	c.(31-33)CCT>CTT	p.P11L	SUN1_uc010ksa.1_Missense_Mutation_p.P32L|SUN1_uc003sje.1_Missense_Mutation_p.P11L|SUN1_uc003sjf.2_Intron|SUN1_uc011jvq.1_Missense_Mutation_p.P11L	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	11	Nuclear.|LMNA-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						ATGTACAGTCCTCCCCAGTGT	0.552													9	8					0	0	0.000442599	0	0
SDK1	221935	broad.mit.edu	37	7	4050701	4050701	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:4050701G>A	uc003smx.2	+	15	2374	c.2235G>A	c.(2233-2235)GCG>GCA	p.A745A	SDK1_uc010kso.2_Silent_p.A21A	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	745	Fibronectin type-III 1.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGGTGTGCGCGGTGAATGAAG	0.622													9	24					0	0	0.000274275	0	0
KIAA0415	9907	broad.mit.edu	37	7	4830963	4830963	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:4830963C>T	uc003sne.2	+	17	2454	c.2371C>T	c.(2371-2373)CTG>TTG	p.L791L	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Silent_p.L268L	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	791					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		GCCCCTGGCCCTGCGCACGGT	0.672													5	7					0	0	0.00116845	0	0
RBAK	57786	broad.mit.edu	37	7	5103441	5103441	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:5103441T>C	uc010kss.1	+	6	678	c.354T>C	c.(352-354)TTT>TTC	p.F118F	LOC389458_uc003snr.2_Intron|RBAK_uc003sns.1_Silent_p.F118F	NM_021163	NP_066986	Q9NYW8	RBAK_HUMAN	RB-associated KRAB repressor	118					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(3)|kidney(1)|skin(1)	5		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		AGAATACATTTAGTCAAATTT	0.343													35	40					0	0	0.000953801	0	0
GLCCI1	113263	broad.mit.edu	37	7	8125850	8125850	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:8125850C>T	uc003srk.2	+	8	1885	c.1326C>T	c.(1324-1326)CTC>CTT	p.L442L		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	442											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CGGCCCCTCTCTTTTCATGTC	0.393													64	222					0	0	0.000781405	0	0
PRPS1L1	221823	broad.mit.edu	37	7	18066477	18066477	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:18066477G>A	uc003stz.2	-	1	1010	c.929C>T	c.(928-930)TCC>TTC	p.S310F		NM_175886	NP_787082	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like	310					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			ovary(1)	1	Lung NSC(10;0.0385)|all_lung(11;0.0736)					GAACAGGTAGGAAACAGATTC	0.328													182	161					0	0	0.000781405	0	0
HDAC9	9734	broad.mit.edu	37	7	18669046	18669046	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:18669046C>T	uc003suh.2	+	6	770	c.729C>T	c.(727-729)CTC>CTT	p.L243L	HDAC9_uc003sue.2_Silent_p.L243L|HDAC9_uc011jyd.1_Silent_p.L243L|HDAC9_uc003sui.2_Silent_p.L246L|HDAC9_uc003suj.2_Intron|HDAC9_uc011jya.1_Intron|HDAC9_uc003sua.1_Intron|HDAC9_uc011jyb.1_Intron|HDAC9_uc003sud.1_Silent_p.L243L|HDAC9_uc011jyc.1_Intron|HDAC9_uc003suf.1_Silent_p.L274L|HDAC9_uc010kud.1_Silent_p.L246L|HDAC9_uc011jye.1_Silent_p.L215L|HDAC9_uc011jyf.1_Intron|HDAC9_uc010kue.1_5'UTR	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	243	Interaction with MAPK10 (By similarity).|Interaction with ETV6.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GCCCCTTACTCAGGCGGAAGG	0.473													29	24					0	0	0.00127121	0	0
HDAC9	9734	broad.mit.edu	37	7	18705909	18705909	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:18705909G>A	uc003suh.2	+	11	1573	c.1532G>A	c.(1531-1533)GGG>GAG	p.G511E	HDAC9_uc003sue.2_Missense_Mutation_p.G511E|HDAC9_uc011jyd.1_Missense_Mutation_p.G511E|HDAC9_uc003sui.2_Missense_Mutation_p.G514E|HDAC9_uc003suj.2_Missense_Mutation_p.G470E|HDAC9_uc011jya.1_Missense_Mutation_p.G508E|HDAC9_uc003sua.1_Missense_Mutation_p.G489E|HDAC9_uc011jyb.1_Missense_Mutation_p.G467E|HDAC9_uc003sud.1_Missense_Mutation_p.G511E|HDAC9_uc011jyc.1_Missense_Mutation_p.G470E|HDAC9_uc003suf.1_Missense_Mutation_p.G542E|HDAC9_uc010kud.1_Missense_Mutation_p.G514E|HDAC9_uc011jye.1_Missense_Mutation_p.G483E|HDAC9_uc011jyf.1_Missense_Mutation_p.G434E|HDAC9_uc010kue.1_Intron	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	511					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	GAGCTTCAGGGGGACCAGGCG	0.532											OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	100					0	0	0.0024448	0	0
DNAH11	8701	broad.mit.edu	37	7	21628202	21628203	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:21628202_21628203GT>AA	uc003svc.2	+	11	1952_1953	c.1921_1922GT>AA	c.(1921-1923)GTT>AAT	p.V641N		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	641	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGCCCAGCAGGTTCTCCAACGA	0.406									Kartagener_syndrome				110	73					0	0	6.4e-05	0	0
DNAH11	8701	broad.mit.edu	37	7	21630843	21630843	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:21630843A>T	uc003svc.2	+	14	2346	c.2315A>T	c.(2314-2316)AAA>ATA	p.K772I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	772	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GGGTATAATAAACTCAAACAG	0.433									Kartagener_syndrome				44	28					0	0	0.00222228	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23391174	23391174	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:23391174C>G	uc003swg.2	-	6	699	c.433G>C	c.(433-435)GAG>CAG	p.E145Q		NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	145	RRM 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						GTGAAATTCTCTAACTGAAAT	0.502													33	39					0	0	0.00058488	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23391184	23391184	+	Silent	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:23391184T>A	uc003swg.2	-	6	689	c.423A>T	c.(421-423)GGA>GGT	p.G141G		NM_006547	NP_006538	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding	141	RRM 2.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			ovary(2)	2						CTAACTGAAATCCATTCAGTT	0.493													30	42					0	0	0.00209593	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27788280	27788280	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:27788280C>A	uc003szl.2	+	2	295	c.137C>A	c.(136-138)CCA>CAA	p.P46Q	TAX1BP1_uc011jzo.1_Missense_Mutation_p.P46Q|TAX1BP1_uc003szk.2_Missense_Mutation_p.P46Q|TAX1BP1_uc011jzp.1_5'UTR	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	46					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			CATCCACATCCAAAAGATTGG	0.343													13	629					0.00185496	0.00761374	0.00185496	1	0
FAM188B	84182	broad.mit.edu	37	7	30921964	30921964	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:30921964C>T	uc003tbt.2	+	16	2217	c.2140C>T	c.(2140-2142)CGG>TGG	p.R714W	FAM188B_uc010kwe.2_Missense_Mutation_p.R685W|AQP1_uc011kac.1_Missense_Mutation_p.R60W|FAM188B_uc003tbu.2_Missense_Mutation_p.R234W	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	714											0						GGAGCAGATCCGGCTGACCAT	0.627													6	19					0	0	0.00116845	0	0
NPSR1	387129	broad.mit.edu	37	7	34851447	34851447	+	Silent	SNP	C	T	T	rs116733850	byFrequency	TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:34851447C>T	uc003teg.1	+	4	578	c.450C>T	c.(448-450)ATC>ATT	p.I150I	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Silent_p.I150I|NPSR1_uc010kwt.1_5'UTR|NPSR1_uc010kwu.1_Intron|NPSR1_uc010kwv.1_Intron|NPSR1_uc003tei.1_Silent_p.I150I|NPSR1_uc010kww.1_Silent_p.I139I|NPSR1_uc011kar.1_Intron|AAA1_uc010kwy.2_Intron|AAA1_uc003tek.3_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	150	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	ACCATGCCATCGTCTACCCCA	0.468													82	75					0	0	0.000781405	0	0
TBX20	57057	broad.mit.edu	37	7	35244129	35244129	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:35244129C>T	uc011kas.1	-	7	967	c.956G>A	c.(955-957)GGA>GAA	p.G319E		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	319						nucleus	DNA binding			central_nervous_system(1)	1						ATCTTCTTCTCCTCCGTAGGT	0.483													14	35					0	0	0.000566183	0	0
GCK	2645	broad.mit.edu	37	7	44191959	44191960	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:44191959_44191960CC>AA	uc003tkl.2	-	3	743_744	c.273_274GG>TT	c.(271-276)GTGGGA>GTTTGA	p.G92*	GCK_uc003tkj.1_Nonsense_Mutation_p.G91*|GCK_uc003tkk.1_Nonsense_Mutation_p.G93*	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	92					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						TCACCTTCTCCCACCTTCACCA	0.589													15	501					0	0	6.4e-05	0	0
MYO1G	64005	broad.mit.edu	37	7	45005329	45005329	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:45005329C>T	uc003tmh.2	-	17	2432	c.2288G>A	c.(2287-2289)AGG>AAG	p.R763K	MYO1G_uc003tmf.2_Missense_Mutation_p.R206K|MYO1G_uc003tmg.2_Missense_Mutation_p.R525K|MYO1G_uc010kym.2_Missense_Mutation_p.R648K	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	763						myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						TGGCGGCTGCCTTGCAGCCTG	0.647													13	25					0	0	0.00136819	0	0
C7orf65	401335	broad.mit.edu	37	7	47694908	47694908	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:47694908G>A	uc010kyp.1	+	1	67	c.32G>A	c.(31-33)GGA>GAA	p.G11E		NM_001123065	NP_001116537	Q6ZTY9	CG065_HUMAN	hypothetical protein LOC401335	11											0						TCAACAGAAGGAAGACGGCTC	0.428													8	29					0	0	0.000442599	0	0
PKD1L1	168507	broad.mit.edu	37	7	47882569	47882569	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:47882569C>T	uc003tny.1	-	34	5436	c.5436G>A	c.(5434-5436)TTG>TTA	p.L1812L		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1812	PLAT.|Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						CCTTTGAGGTCAACCTGGCCG	0.517													20	59					0	0	0.00188189	0	0
PKD1L1	168507	broad.mit.edu	37	7	47894550	47894550	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:47894550C>T	uc003tny.1	-	30	4789	c.4789G>A	c.(4789-4791)GAA>AAA	p.E1597K		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1597	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TGTAGAGATTCCTGGGGGTTT	0.393													34	77					0	0	0.00058488	0	0
ABCA13	154664	broad.mit.edu	37	7	48308582	48308582	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:48308582C>T	uc003toq.2	+	16	2036	c.2011C>T	c.(2011-2013)CCT>TCT	p.P671S	ABCA13_uc010kyr.2_Missense_Mutation_p.P174S	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	671					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTTAGCTTTTCCTGAGGAATC	0.289													24	16					0	0	0.00047179	0	0
ZPBP	11055	broad.mit.edu	37	7	50070802	50070802	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:50070802A>T	uc003tou.2	-	5	662	c.592T>A	c.(592-594)TTA>ATA	p.L198I	ZPBP_uc011kci.1_Missense_Mutation_p.L124I|ZPBP_uc010kyw.2_Missense_Mutation_p.L197I	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	198					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					AGTTTGCTTAAAATCTGAAGA	0.353													47	96					0	0	0.000781405	0	0
LOC442308	442308	broad.mit.edu	37	7	55714363	55714363	+	RNA	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:55714363A>C	uc010kzj.2	+	1		c.1052A>C				NR_003598				Homo sapiens similar to tubulin, beta 5 (LOC442308), non-coding RNA.												0						ACATCAAGACAGCTGTCTGTG	0.502													13	24					0	0	0.000566183	0	0
ZNF479	90827	broad.mit.edu	37	7	57188644	57188644	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:57188644G>A	uc010kzo.2	-	5	749	c.478C>T	c.(478-480)CAT>TAT	p.H160Y		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	160					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ACATATTTATGAGTCTGAAAT	0.303													36	43					0	0	0.00111076	0	0
ZNF679	168417	broad.mit.edu	37	7	63726795	63726795	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:63726795C>T	uc003tsx.2	+	5	1053	c.784C>T	c.(784-786)CAT>TAT	p.H262Y		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	262	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TAGGAGAATTCATACTGGAGA	0.418													8	14					0	0	0.000157383	0	0
RABGEF1	27342	broad.mit.edu	37	7	66273942	66273942	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:66273942C>A	uc011kee.1	+	9	1353	c.1189C>A	c.(1189-1191)CGC>AGC	p.R397S	RABGEF1_uc003tvf.2_Missense_Mutation_p.R256S|RABGEF1_uc003tvg.2_Missense_Mutation_p.R191S|RABGEF1_uc010lag.2_Missense_Mutation_p.R383S|RABGEF1_uc003tvh.2_Missense_Mutation_p.R383S|RABGEF1_uc003tvi.2_Missense_Mutation_p.R217S	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	600					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						GGATTTTGATCGCTACATGTC	0.458													28	52					1.75199e-13	7.31478e-13	0.00127121	1	0
POM121	9883	broad.mit.edu	37	7	72413513	72413513	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:72413513C>T	uc003twk.2	+	11	2981	c.2981C>T	c.(2980-2982)TCT>TTT	p.S994F	POM121_uc003twj.2_Missense_Mutation_p.S729F|POM121_uc010lam.1_Missense_Mutation_p.S729F	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	994	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				TTTGGCAGCTCTTTCACTTTT	0.657													25	99					0	0	0.00106085	0	0
POM121	9883	broad.mit.edu	37	7	72413539	72413539	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:72413539C>T	uc003twk.2	+	11	3007	c.3007C>T	c.(3007-3009)CCG>TCG	p.P1003S	POM121_uc003twj.2_Missense_Mutation_p.P738S|POM121_uc010lam.1_Missense_Mutation_p.P738S	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	1003	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				CTCTGCAGCCCCGGCTGCTGC	0.657													31	110					0	0	0.000953801	0	0
MLXIPL	51085	broad.mit.edu	37	7	73012022	73012022	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:73012022G>A	uc003tyn.1	-	9	1141	c.1093C>T	c.(1093-1095)CCC>TCC	p.P365S	MLXIPL_uc003tyj.1_5'UTR|MLXIPL_uc003tyk.1_Missense_Mutation_p.P365S|MLXIPL_uc003tyl.1_Missense_Mutation_p.P365S|MLXIPL_uc003tym.1_Missense_Mutation_p.P365S|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.P272S|MLXIPL_uc003tyq.1_Missense_Mutation_p.P107S	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	365					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				GAGTCCAAGGGGCCAGGGCAG	0.647													21	23					0	0	0.000586117	0	0
CLDN3	1365	broad.mit.edu	37	7	73184200	73184200	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:73184200C>T	uc003tzg.3	-	1	401	c.180G>A	c.(178-180)CAG>CAA	p.Q60Q	RFC2_uc011kfa.1_Intron	NM_001306	NP_001297	O15551	CLD3_HUMAN	claudin 3	60	Extracellular (Potential).				response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				TGCACTGCATCTGGCCGGTGC	0.652													13	31					0	0	0.00185496	0	0
ELN	2006	broad.mit.edu	37	7	73474215	73474215	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:73474215G>T	uc003tzw.2	+	23	1523	c.1432G>T	c.(1432-1434)GGG>TGG	p.G478W	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Splice_Site_p.G472_splice|ELN_uc003tzz.2_Splice_Site_p.G391_splice|ELN_uc003tzo.2_Splice_Site_p.G439_splice|ELN_uc003tzp.2_Splice_Site_p.G383_splice|ELN_uc003tzq.2_Splice_Site_p.G336_splice|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Splice_Site_p.G453_splice|ELN_uc003tzt.2_Splice_Site_p.G477_splice|ELN_uc003tzu.2_Splice_Site_p.G458_splice|ELN_uc003tzv.2_Splice_Site_p.G443_splice|ELN_uc003tzx.2_Splice_Site_p.G462_splice|ELN_uc011kff.1_Splice_Site_p.G472_splice|ELN_uc003tzy.2_Splice_Site_p.G448_splice	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	501	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CAATCTTGCAGGGTTAGTTCC	0.398			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						9	319					0.000442599	0.00182508	0.000442599	1	0
SRCRB4D	136853	broad.mit.edu	37	7	76026865	76026865	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:76026865G>A	uc003ufb.2	-	6	1186	c.838C>T	c.(838-840)CAC>TAC	p.H280Y	ZP3_uc003ufc.3_5'UTR	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	280	SRCR 2.					extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						TCCTCGTGGTGGCCGCAGTTG	0.736													5	4					0	0	0.000602214	0	0
CCDC146	57639	broad.mit.edu	37	7	76908140	76908140	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:76908140A>T	uc003uga.2	+	12	1639	c.1512A>T	c.(1510-1512)AAA>AAT	p.K504N	CCDC146_uc010ldp.2_Missense_Mutation_p.K218N	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	504	Poly-Lys.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				AGAAGAAAAAATGTGAAATTT	0.299													24	44					0	0	0.000375601	0	0
MAGI2	9863	broad.mit.edu	37	7	77708295	77708295	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:77708295G>A	uc003ugx.2	-	21	3929	c.3675C>T	c.(3673-3675)CTC>CTT	p.L1225L	MAGI2_uc003ugy.2_Silent_p.L1211L|MAGI2_uc010ldx.1_Silent_p.L818L	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	1225	PDZ 6.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGCCTCTCTTGAGCAGCAGCC	0.433													67	116					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82475907	82475907	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:82475907C>T	uc003uhx.2	-	12	14096	c.13807G>A	c.(13807-13809)GAA>AAA	p.E4603K	PCLO_uc003uhv.2_Missense_Mutation_p.E4603K|PCLO_uc003uht.1_Missense_Mutation_p.E54K|PCLO_uc003uhu.1_Missense_Mutation_p.E33K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4491					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCATGAAGTTCCAGATGCTGG	0.338													19	48					0	0	0.000586117	0	0
PCLO	27445	broad.mit.edu	37	7	82544905	82544905	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:82544905G>A	uc003uhx.2	-	7	12686	c.12397C>T	c.(12397-12399)CGT>TGT	p.R4133C	PCLO_uc003uhv.2_Missense_Mutation_p.R4133C|PCLO_uc010lec.2_Missense_Mutation_p.R1098C	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4064					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCCCTCTACGAAATTCCTGT	0.408													60	47					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82584970	82584970	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:82584970A>C	uc003uhx.2	-	5	5588	c.5299T>G	c.(5299-5301)TTG>GTG	p.L1767V	PCLO_uc003uhv.2_Missense_Mutation_p.L1767V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1698					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATAGTAGGCAAAAGAGGGCCA	0.433													48	167					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82585451	82585451	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:82585451C>T	uc003uhx.2	-	5	5107	c.4818G>A	c.(4816-4818)GGG>GGA	p.G1606G	PCLO_uc003uhv.2_Silent_p.G1606G	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1537					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCTGTGTTTCCCTGCTGTTA	0.418													87	259					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82785303	82785303	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:82785303C>T	uc003uhx.2	-	2	943	c.654G>A	c.(652-654)CCG>CCA	p.P218P	PCLO_uc003uhv.2_Silent_p.P218P	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	218	Gln-rich.|Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCTTAGGAATCGGCTTGGGTG	0.448													26	15					0	0	0.00106085	0	0
ABCB1	5243	broad.mit.edu	37	7	87175237	87175237	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:87175237C>T	uc003uiz.1	-	16	2247	c.1829G>A	c.(1828-1830)GGA>GAA	p.G610E	ABCB1_uc011khc.1_Missense_Mutation_p.G546E	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	610	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATCATGATTTCCTTTCTCCAC	0.398													23	73					0	0	0.000375601	0	0
AKAP9	10142	broad.mit.edu	37	7	91641942	91641942	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:91641942A>G	uc003ulg.2	+	9	3743	c.3518A>G	c.(3517-3519)AAA>AGA	p.K1173R	AKAP9_uc003ule.2_Missense_Mutation_p.K1185R|AKAP9_uc003ulf.2_Missense_Mutation_p.K1173R|AKAP9_uc003uli.2_Missense_Mutation_p.K798R	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1185	Potential.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGACTATGAAAACACAAGAA	0.338			T	BRAF	papillary thyroid								48	35					0	0	0.000781405	0	0
ZNF498	221785	broad.mit.edu	37	7	99221679	99221679	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:99221679G>A	uc003url.1	+	7	1009	c.682_splice	c.e7-1	p.G228_splice	ZNF498_uc003urm.1_Splice_Site_p.G64_splice|ZNF498_uc010lge.1_Splice_Site_p.G64_splice|ZNF498_uc003urn.2_Splice_Site|ZNF498_uc010lgf.1_Intron|ZNF498_uc003uro.1_Splice_Site_p.G12_splice	NM_145115	NP_660090	Q6NSZ9	ZN498_HUMAN	zinc finger and SCAN domain containing 25						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_epithelial(64;1.95e-08)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					TATTGTTGCAGGGGTTGGGGC	0.512													44	96					0	0	0.000781405	0	0
ARMC10	83787	broad.mit.edu	37	7	102738832	102738832	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:102738832G>A	uc003vaw.1	+	7	1256	c.864G>A	c.(862-864)AAG>AAA	p.K288K	ARMC10_uc003vay.1_Silent_p.K229K|ARMC10_uc003vax.1_Silent_p.K253K|ARMC10_uc003vbb.1_Silent_p.K194K|ARMC10_uc011kli.1_Silent_p.K229K|ARMC10_uc010lis.1_Silent_p.K170K|ARMC10_uc003vba.1_RNA|ARMC10_uc003vaz.1_Silent_p.K166K	NM_031905	NP_114111	Q8N2F6	ARM10_HUMAN	SVH protein isoform a	288					regulation of growth	endoplasmic reticulum membrane|integral to membrane	binding			ovary(1)	1						AGAATATAAAGAACTGCCTCA	0.388													23	137					0	0	0.000720815	0	0
RELN	5649	broad.mit.edu	37	7	103276823	103276823	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:103276823G>A	uc003vca.2	-	18	2322	c.2162C>T	c.(2161-2163)TCC>TTC	p.S721F	RELN_uc010liz.2_Missense_Mutation_p.S721F	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	721					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATGGTAAGAGGAGAGCCTGGA	0.488													32	32					0	0	0.000491102	0	0
SLC26A3	1811	broad.mit.edu	37	7	107434305	107434305	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:107434305C>T	uc003ver.2	-	3	364	c.153G>A	c.(151-153)AAG>AAA	p.K51K	SLC26A3_uc003ves.2_Intron	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	51					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						GGACAATTCTCTTGGCCTTTT	0.423													37	33					0	0	0.00111076	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113517931	113517931	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:113517931G>A	uc010ljy.1	-	4	3247	c.3216C>T	c.(3214-3216)ACC>ACT	p.T1072T		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	1072					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						TTTTAGAGTTGGTATATTTTG	0.348													78	64					0	0	0.000781405	0	0
C7orf58	79974	broad.mit.edu	37	7	120911459	120911459	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:120911459G>A	uc003vjq.3	+	22	3290	c.2843G>A	c.(2842-2844)GGG>GAG	p.G948E		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	948						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTTCTACAGGGGAAGTGTGGA	0.323													89	72					0	0	0.000781405	0	0
LMOD2	442721	broad.mit.edu	37	7	123302262	123302262	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:123302262A>T	uc003vky.2	+	2	779	c.622A>T	c.(622-624)AGC>TGC	p.S208C		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	208						cytoskeleton	actin binding|tropomyosin binding				0						CAAGATTAAAAGCAATGACCC	0.473													10	37					0	0	0.000673444	0	0
RBM28	55131	broad.mit.edu	37	7	127958082	127958082	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:127958082G>A	uc003vmp.2	-	15	1756	c.1641C>T	c.(1639-1641)TTC>TTT	p.F547F	RBM28_uc003vmo.2_Intron|RBM28_uc011koj.1_Silent_p.F406F	NM_018077	NP_060547	Q9NW13	RBM28_HUMAN	RNA binding motif protein 28	547	RRM 4.				mRNA processing|RNA splicing	Golgi apparatus|nucleolus|spliceosomal complex	nucleotide binding|RNA binding			ovary(2)	2						CGTGCTCTTGGAACTCCGCAA	0.512													10	38					0	0	0.000442599	0	0
COPG2	26958	broad.mit.edu	37	7	130295824	130295825	+	Splice_Site	DNP	CC	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:130295824_130295825CC>AA	uc003vqh.1	-	10	2236	c.2146_splice	c.e10+1	p.A716_splice		NM_012133	NP_036265	Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2						intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity				0	Melanoma(18;0.0435)					AGACACTTACCCATCCTCAGTT	0.371													11	456					0	0	6.4e-05	0	0
LRGUK	136332	broad.mit.edu	37	7	133943058	133943058	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:133943058C>T	uc003vrm.1	+	19	2264	c.2248C>T	c.(2248-2250)CCG>TCG	p.P750S		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	750							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						TCGGTTCTGTCCGTGGTCAAA	0.458													66	59					0	0	0.000781405	0	0
TRIM24	8805	broad.mit.edu	37	7	138262304	138262304	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:138262304G>A	uc003vuc.2	+	14	2442	c.2227G>A	c.(2227-2229)GAA>AAA	p.E743K	TRIM24_uc003vub.2_Missense_Mutation_p.E709K	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	743					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						AGTGAAGCAAGAATCAGATGA	0.393													16	90					0	0	0.000958276	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				68	53					0	0	0.000781405	0	0
MGAM	8972	broad.mit.edu	37	7	141758041	141758042	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:141758041_141758042GG>TT	uc003vwy.2	+	31	3786_3787	c.3732_3733GG>TT	c.(3730-3735)TTGGGG>TTTTGG	p.1244_1245LG>FW		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1244_1245	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACTGGTCTTTGGGGTTCCAGCT	0.465													12	588					0	0	6.4e-05	0	0
PRSS1	5644	broad.mit.edu	37	7	142459672	142459672	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:142459672G>A	uc003wak.2	+	3	265	c.248G>A	c.(247-249)GGG>GAG	p.G83E	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.G23E	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	83	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GTCCTGGAGGGGAATGAGCAG	0.542									Hereditary_Pancreatitis				50	166					0	0	0.000781405	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175718	143175718	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:143175718C>T	uc003wdc.1	+	1	753	c.753C>T	c.(751-753)ATC>ATT	p.I251I	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	251	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					TGTCCCTGATCATTGATGCCG	0.502													54	75					0	0	0.000781405	0	0
TPK1	27010	broad.mit.edu	37	7	144150682	144150682	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:144150682C>T	uc003weq.2	-	9	791	c.688G>A	c.(688-690)GAA>AAA	p.E230K	TPK1_uc003weo.2_Missense_Mutation_p.E176K|TPK1_uc003wep.2_RNA|TPK1_uc003wer.2_Missense_Mutation_p.E181K|TPK1_uc003wes.2_RNA	NM_022445	NP_071890	Q9H3S4	TPK1_HUMAN	thiamin pyrophosphokinase 1 isoform a	230					thiamine diphosphate biosynthetic process	cytosol	ATP binding|kinase activity|thiamine diphosphokinase activity			ovary(2)	2					Thiamine(DB00152)	TGGTCAGTTTCCACAGTCACA	0.443													105	62					0	0	0.000781405	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146805346	146805346	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:146805346G>A	uc003weu.1	+	5	1174	c.658G>A	c.(658-660)GAA>AAA	p.E220K		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	220	Laminin G-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TAAGACGTCTGAAAGTGAAGG	0.388										HNSCC(39;0.1)			21	64					0	0	0.000375601	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147914545	147914545	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:147914545A>C	uc003weu.1	+	19	3692	c.3176A>C	c.(3175-3177)AAG>ACG	p.K1059T		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1059	Laminin G-like 4.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AGCACCACCAAGGCGCCCTGC	0.587										HNSCC(39;0.1)			52	55					0	0	0.000781405	0	0
ZNF767	79970	broad.mit.edu	37	7	149317098	149317098	+	RNA	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:149317098G>A	uc003wfy.3	-	4		c.707C>T			ZNF767_uc003wfx.2_RNA|ZNF767_uc011kuq.1_RNA	NR_027789				Homo sapiens cDNA FLJ12700 fis, clone NT2RP1000721.											central_nervous_system(1)	1	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00434)			TTCAATCTGGGAGAGGACCTC	0.557													14	30					0	0	0.000566183	0	0
SSPO	23145	broad.mit.edu	37	7	149486750	149486750	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:149486750C>T	uc010lpk.2	+	31	4524	c.4524C>T	c.(4522-4524)ATC>ATT	p.I1508I		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1508	LDL-receptor class A 4.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGGGGCCATCCAGCTGTGTG	0.652													6	5					0	0	0.00116845	0	0
ABP1	26	broad.mit.edu	37	7	150558262	150558263	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:150558262_150558263CC>TT	uc003why.1	+	6	6439_6440	c.2221_2222CC>TT	c.(2221-2223)CCT>TTT	p.P741F	ABP1_uc003whz.1_Missense_Mutation_p.P741F|ABP1_uc003wia.1_Missense_Mutation_p.P760F	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	741					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	GATGCCTCCCCCTTTTAGCTAC	0.51													10	26					0	0	6.4e-05	0	0
NOS3	4846	broad.mit.edu	37	7	150696062	150696062	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:150696062G>A	uc003wif.2	+	8	1141	c.845G>A	c.(844-846)GGA>GAA	p.G282E	NOS3_uc011kuy.1_Missense_Mutation_p.G76E|NOS3_uc011kuz.1_Missense_Mutation_p.G282E|NOS3_uc011kva.1_Missense_Mutation_p.G282E|NOS3_uc011kvb.1_Missense_Mutation_p.G282E	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	282	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TGGACCCCAGGAAACGGTCGC	0.662													22	44					0	0	0.00188189	0	0
HTR5A	3361	broad.mit.edu	37	7	154876080	154876080	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:154876080G>A	uc003wlu.1	+	2	1021	c.957G>A	c.(955-957)TGG>TGA	p.W319*		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	319	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CCGCCATCTGGAAAAGCATCT	0.522													92	73					0	0	0.000781405	0	0
PTPRN2	5799	broad.mit.edu	37	7	157985162	157985162	+	Missense_Mutation	SNP	C	T	T	rs146516476		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr7:157985162C>T	uc003wno.2	-	5	527	c.406G>A	c.(406-408)GAG>AAG	p.E136K	PTPRN2_uc003wnp.2_Missense_Mutation_p.E119K|PTPRN2_uc003wnq.2_Missense_Mutation_p.E136K|PTPRN2_uc003wnr.2_Missense_Mutation_p.E98K|PTPRN2_uc011kwa.1_Missense_Mutation_p.E159K	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	136	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TACCTCCTCTCGCTGCCAACG	0.632													60	41					0	0	0.000781405	0	0
DLGAP2	9228	broad.mit.edu	37	8	1624744	1624744	+	Nonsense_Mutation	SNP	G	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:1624744G>T	uc003wpl.2	+	8	2105	c.2008G>T	c.(2008-2010)GAA>TAA	p.E670*	DLGAP2_uc003wpm.2_Nonsense_Mutation_p.E656*	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	749					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CGGTCTGCGGGAATACCACTC	0.562													6	3					5.18039e-06	2.15111e-05	0.000157383	1	0
TNKS	8658	broad.mit.edu	37	8	9588486	9588486	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:9588486C>T	uc003wss.2	+	14	2093	c.2088C>T	c.(2086-2088)CGC>CGT	p.R696R	TNKS_uc011kww.1_Silent_p.R459R|TNKS_uc010lrs.1_RNA	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	696	ANK 10.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		GCTACAACCGCGTGTCTGTTG	0.507													22	14					0	0	0.00047179	0	0
RP1L1	94137	broad.mit.edu	37	8	10469042	10469042	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:10469042G>A	uc003wtc.2	-	4	2795	c.2566C>T	c.(2566-2568)CCG>TCG	p.P856S		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	856					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCCCTGGGCGGGGTGGGACAG	0.726													5	2					0	0	0.00116845	0	0
BLK	640	broad.mit.edu	37	8	11415549	11415549	+	Splice_Site	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:11415549T>C	uc003wty.2	+	10	1610	c.1029_splice	c.e10+2	p.Q343_splice	BLK_uc003wtz.2_Splice_Site_p.Q272_splice|BLK_uc003wua.2_5'Flank	NM_001715	NP_001706	P51451	BLK_HUMAN	B lymphoid tyrosine kinase						intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			large_intestine(1)|stomach(1)|ovary(1)	3			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		TCGGCGCAGGTTGGTGAAGTA	0.323													19	11					0	0	0.00121646	0	0
LONRF1	91694	broad.mit.edu	37	8	12594427	12594427	+	Nonsense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:12594427T>A	uc003wwd.1	-	5	1399	c.1336A>T	c.(1336-1338)AAG>TAG	p.K446*	LONRF1_uc011kxv.1_Nonsense_Mutation_p.K46*|LONRF1_uc010lsp.1_Nonsense_Mutation_p.K46*	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	446					proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		TTTTTCAGCTTATTTCTTCCA	0.308													8	7					0	0	0.000157383	0	0
HR	55806	broad.mit.edu	37	8	21986204	21986204	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:21986204G>A	uc003xas.2	-	2	1145	c.480C>T	c.(478-480)CCC>CCT	p.P160P	HR_uc003xat.2_Silent_p.P160P|HR_uc010lts.2_Silent_p.P160P	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	160							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GCAAGCAGGTGGGCACCCAGA	0.652													4	7					0	0	0.000602214	0	0
HR	55806	broad.mit.edu	37	8	21986541	21986542	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:21986541_21986542GG>AA	uc003xas.2	-	2	807_808	c.142_143CC>TT	c.(142-144)CCC>TTC	p.P48F	HR_uc003xat.2_Missense_Mutation_p.P48F|HR_uc010lts.2_Missense_Mutation_p.P48F	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	48							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CCTCCAAAAGGGAGCAGGCTCT	0.688													12	25					0	0	6.4e-05	0	0
CHRNA2	1135	broad.mit.edu	37	8	27327415	27327415	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:27327415C>T	uc010lur.2	-	3	766	c.157G>A	c.(157-159)GGC>AGC	p.G53S	CHRNA2_uc011lal.1_Missense_Mutation_p.G53S|CHRNA2_uc010lus.2_5'UTR	NM_000742	NP_000733	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha	53	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)	1		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine(DB01336)|Metocurine Iodide(DB00416)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GTATGCGAGCCTCCCTGCGGC	0.622													22	36					0	0	0.000375601	0	0
KIF13B	23303	broad.mit.edu	37	8	29023289	29023289	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:29023289C>T	uc003xhh.3	-	12	1218	c.1159G>A	c.(1159-1161)GCA>ACA	p.A387T	KIF13B_uc003xhj.2_Missense_Mutation_p.A284T|KIF13B_uc010lvf.1_Missense_Mutation_p.A323T	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	387	Potential.				microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		GATTTCATTGCCTACAAGCAA	0.428													15	42					0	0	0.000422831	0	0
GTF2E2	2961	broad.mit.edu	37	8	30511065	30511065	+	Silent	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:30511065A>T	uc003xig.2	-	2	304	c.51T>A	c.(49-51)CTT>CTA	p.L17L		NM_002095	NP_002086	P29084	T2EB_HUMAN	general transcription factor IIE, polypeptide 2,	17					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription factor TFIIE complex	DNA binding|protein binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.113)|Kidney(114;0.135)		CAGGAGTAGAAAGAGCTCGTT	0.383													25	39					0	0	0.000375601	0	0
KCNU1	157855	broad.mit.edu	37	8	36793288	36793288	+	Silent	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:36793288T>A	uc010lvw.2	+	27	3387	c.3300T>A	c.(3298-3300)TCT>TCA	p.S1100S		NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1100	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACTCCCTCTCTTTTCCTAAGC	0.373													58	119					0	0	0.000781405	0	0
ADAM2	2515	broad.mit.edu	37	8	39604026	39604026	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:39604026C>T	uc003xnj.2	-	19	2214	c.2139G>A	c.(2137-2139)AGG>AGA	p.R713R	ADAM2_uc003xnk.2_Silent_p.R694R|ADAM2_uc011lck.1_Silent_p.R650R|ADAM2_uc003xnl.2_Silent_p.R557R	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	713	Cytoplasmic (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TCCATTTTTTCCTTTGGAAAT	0.284													51	76					0	0	0.000781405	0	0
MYST3	7994	broad.mit.edu	37	8	41791374	41791374	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:41791374G>A	uc010lxb.2	-	18	4908	c.4364C>T	c.(4363-4365)ACC>ATC	p.T1455I	MYST3_uc010lxc.2_Missense_Mutation_p.T1455I|MYST3_uc003xon.3_Missense_Mutation_p.T1455I	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1455					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			ACTCTGCAGGGTCTGACACGC	0.527													29	64					0	0	0.0024448	0	0
IKBKB	3551	broad.mit.edu	37	8	42175288	42175288	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:42175288C>T	uc003xow.1	+	12	1416	c.1239C>T	c.(1237-1239)ATC>ATT	p.I413I	IKBKB_uc010lxh.1_Silent_p.I308I|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Silent_p.I190I|IKBKB_uc003xox.1_Silent_p.I134I|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Silent_p.I411I|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Silent_p.I354I	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	413					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	TCAGCTGTATCCGTAAGAATT	0.428													19	43					0	0	0.000958276	0	0
CPA6	57094	broad.mit.edu	37	8	68419059	68419059	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:68419059C>T	uc003xxq.3	-	6	855	c.599G>A	c.(598-600)TGG>TAG	p.W200*	CPA6_uc003xxr.3_Nonsense_Mutation_p.W52*|CPA6_uc003xxs.2_Nonsense_Mutation_p.W200*	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	200					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AGGACCAATCCATTCTCTTGC	0.423													26	41					0	0	0.00058488	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767758	77767758	+	Silent	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:77767758T>A	uc003yav.2	+	10	8853	c.8466T>A	c.(8464-8466)TCT>TCA	p.S2822S	ZFHX4_uc003yau.1_Silent_p.S2867S|ZFHX4_uc003yaw.1_Silent_p.S2822S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2822						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCTCTTTTCTCTCACAAGCC	0.493										HNSCC(33;0.089)			13	27					0	0	0.000308642	0	0
CDH17	1015	broad.mit.edu	37	8	95183151	95183151	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:95183151G>A	uc003ygh.2	-	8	971	c.846C>T	c.(844-846)TTC>TTT	p.F282F	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Silent_p.F282F	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	282	Extracellular (Potential).|Cadherin 3.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TTGAAAATGGGAATCTTGGCA	0.463													48	82					0	0	0.000781405	0	0
CDH17	1015	broad.mit.edu	37	8	95186178	95186178	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:95186178C>T	uc003ygh.2	-	7	755	c.630G>A	c.(628-630)GTG>GTA	p.V210V	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Silent_p.V210V	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	210	Extracellular (Potential).|Cadherin 2.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCACTGAGATCACCAGATTAT	0.443													20	27					0	0	0.00152264	0	0
ESRP1	54845	broad.mit.edu	37	8	95653669	95653669	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:95653669C>T	uc003ygq.3	+	1	306	c.123C>T	c.(121-123)GCC>GCT	p.A41A	ESRP1_uc003ygr.3_Silent_p.A41A|ESRP1_uc003ygs.3_Silent_p.A41A|ESRP1_uc003ygt.3_Silent_p.A41A|ESRP1_uc003ygu.3_Silent_p.A41A	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	41					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						TGGATCTGGCCAACAAGAAGG	0.527													119	169					0	0	0.000781405	0	0
C8orf47	203111	broad.mit.edu	37	8	99102037	99102037	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:99102037G>A	uc003yih.1	+	2	940	c.792G>A	c.(790-792)GAG>GAA	p.E264E		NM_173549	NP_775820	Q6P6B1	CH047_HUMAN	hypothetical protein LOC203111	264	Glu-rich.										0	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			TTCCCAAAGAGAATGTAACAC	0.448													15	13					0	0	0.000422831	0	0
FBXO43	286151	broad.mit.edu	37	8	101146071	101146071	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:101146071G>A	uc003yjd.2	-	5	2799	c.2086C>T	c.(2086-2088)CCA>TCA	p.P696S	FBXO43_uc003yje.2_Missense_Mutation_p.P662S	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	696					meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			GCACTTCCTGGGAGAGCATCT	0.403													41	43					0	0	0.00148497	0	0
DPYS	1807	broad.mit.edu	37	8	105405064	105405064	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:105405064G>A	uc003yly.3	-	8	1520	c.1391C>T	c.(1390-1392)CCT>CTT	p.P464L	DPYS_uc010mcf.1_Missense_Mutation_p.P34L	NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	464					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGGTTTTCGAGGAATAAACTT	0.493													45	106					0	0	0.000589545	0	0
DPYS	1807	broad.mit.edu	37	8	105440221	105440221	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:105440221C>A	uc003yly.3	-	6	1208	c.1079G>T	c.(1078-1080)TGG>TTG	p.W360L		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	360			W -> R (in DHPD).		protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCCTTTTTCCCATATTACGGA	0.483													7	146					0.00198382	0.00813015	0.00198382	1	0
ABRA	137735	broad.mit.edu	37	8	107773671	107773671	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:107773671C>T	uc003ymm.3	-	2	794	c.740G>A	c.(739-741)GGG>GAG	p.G247E		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	247	Interaction with actin (By similarity).				positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CTGCCATCTCCCTTTCAAGTT	0.468													34	57					0	0	0.00058488	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110451187	110451187	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:110451187G>A	uc003yne.2	+	32	3926	c.3822G>A	c.(3820-3822)GCG>GCA	p.A1274A		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1274	Extracellular (Potential).|IPT/TIG 6.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAAACATGGCGGTGTATGTTG	0.338										HNSCC(38;0.096)			30	35					0	0	0.00106085	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110464981	110464981	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:110464981C>T	uc003yne.2	+	43	6646	c.6542C>T	c.(6541-6543)TCC>TTC	p.S2181F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2181	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GATGCCTGGTCCTCCAATTTC	0.388										HNSCC(38;0.096)			7	9					0	0	0.000274275	0	0
CSMD3	114788	broad.mit.edu	37	8	113348946	113348946	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:113348946C>T	uc003ynu.2	-	44	7113	c.6954G>A	c.(6952-6954)GGG>GGA	p.G2318G	CSMD3_uc003yns.2_Silent_p.G1520G|CSMD3_uc003ynt.2_Silent_p.G2278G|CSMD3_uc011lhx.1_Silent_p.G2214G|CSMD3_uc003ynw.1_Silent_p.G29G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2318	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGATGCCATTCCCAGGGGGTA	0.348										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			52	69					0	0	0.000781405	0	0
TRPS1	7227	broad.mit.edu	37	8	116616459	116616459	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:116616459G>A	uc003ynz.2	-	3	2157	c.1698C>T	c.(1696-1698)TTC>TTT	p.F566F	TRPS1_uc011lhy.1_Silent_p.F570F|TRPS1_uc003yny.2_Silent_p.F579F|TRPS1_uc010mcy.2_Silent_p.F566F	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	566					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTCTGGGACAGAATGGACAGT	0.443									Langer-Giedion_syndrome				19	25					0	0	0.000958276	0	0
KLHL38	340359	broad.mit.edu	37	8	124658105	124658106	+	Missense_Mutation	DNP	GG	TA	TA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:124658105_124658106GG>TA	uc003yqs.1	-	3	1643_1644	c.1619_1620CC>TA	c.(1618-1620)TCC>TTA	p.S540L		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	540	Kelch 6.										0						CGAAGGAGGCGGAGTCCTCAAT	0.604													5	62					0	0	6.4e-05	0	0
FAM91A1	157769	broad.mit.edu	37	8	124790922	124790922	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:124790922C>T	uc003yqv.2	+	6	520	c.459C>T	c.(457-459)GCC>GCT	p.A153A	FAM91A1_uc011lik.1_Silent_p.A153A|FAM91A1_uc011lil.1_5'UTR	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	153										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			GGAAAACAGCCCGTGATCTTC	0.393													24	34					0	0	0.000878237	0	0
WISP1	8840	broad.mit.edu	37	8	134232969	134232969	+	Silent	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:134232969C>A	uc003yub.2	+	3	571	c.495C>A	c.(493-495)CTC>CTA	p.L165L	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	165	VWFC.				cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CCCCGCGTCTCTGGTGCCCCC	0.672													20	27					0.000295444	0.00121922	0.00229938	1	0
FAM135B	51059	broad.mit.edu	37	8	139165229	139165229	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:139165229C>T	uc003yuy.2	-	13	1660	c.1489G>A	c.(1489-1491)GAA>AAA	p.E497K	FAM135B_uc003yux.2_Missense_Mutation_p.E398K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E59K|FAM135B_uc003yvb.2_Missense_Mutation_p.E59K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	497										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCTGAGATTCAGAGCACATG	0.418										HNSCC(54;0.14)			42	57					0	0	0.00128727	0	0
FAM135B	51059	broad.mit.edu	37	8	139263157	139263157	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:139263157C>T	uc003yuy.2	-	6	640	c.469G>A	c.(469-471)GAC>AAC	p.D157N	FAM135B_uc003yux.2_Missense_Mutation_p.D58N|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	157										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGGAAATAGTCGAACATGACC	0.592										HNSCC(54;0.14)			53	58					0	0	0.000781405	0	0
BAI1	575	broad.mit.edu	37	8	143570778	143570778	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:143570778C>T	uc003ywm.2	+	15	2793	c.2610C>T	c.(2608-2610)ATC>ATT	p.I870I		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	870	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCTTGGAGATCGAGTTTGCCC	0.567													34	42					0	0	0.00148497	0	0
ZFP41	286128	broad.mit.edu	37	8	144332163	144332163	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:144332163C>T	uc003yxw.2	+	2	508	c.150C>T	c.(148-150)CCC>CCT	p.P50P	ZFP41_uc003yxv.2_RNA	NM_173832	NP_776193	Q8N8Y5	ZFP41_HUMAN	zinc finger protein 41 homolog	50					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.6e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCACAGAGCCCTGCCTGAGTC	0.562													10	11					0	0	0.000673444	0	0
FAM83H	286077	broad.mit.edu	37	8	144810890	144810890	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:144810890G>A	uc003yzk.2	-	5	810	c.741C>T	c.(739-741)TTC>TTT	p.F247F	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	247					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGGACCACATGAAGCTGTGGG	0.652													10	21					0	0	0.000978159	0	0
EPPK1	83481	broad.mit.edu	37	8	144941698	144941698	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:144941698C>T	uc003zaa.1	-	1	5737	c.5724G>A	c.(5722-5724)AGG>AGA	p.R1908R		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1908	Plectin 31.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCATGACCTCCCTGGTGGAGG	0.657													10	10					0	0	0.000673444	0	0
PLEC	5339	broad.mit.edu	37	8	145001455	145001455	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr8:145001455G>A	uc003zaf.1	-	28	4386	c.4216C>T	c.(4216-4218)CAG>TAG	p.Q1406*	PLEC_uc003zab.1_Nonsense_Mutation_p.Q1269*|PLEC_uc003zac.1_Nonsense_Mutation_p.Q1273*|PLEC_uc003zad.2_Nonsense_Mutation_p.Q1269*|PLEC_uc003zae.1_Nonsense_Mutation_p.Q1237*|PLEC_uc003zag.1_Nonsense_Mutation_p.Q1247*|PLEC_uc003zah.2_Nonsense_Mutation_p.Q1255*|PLEC_uc003zaj.2_Nonsense_Mutation_p.Q1296*	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1406	Spectrin 4.|Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCAAACCTCTGGCACTCCTCG	0.667													35	78					0	0	0.00148497	0	0
DMRT2	10655	broad.mit.edu	37	9	1051680	1051680	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:1051680G>A	uc003zha.2	+	2	267	c.67G>A	c.(67-69)GAA>AAA	p.E23K	DMRT2_uc003zgx.3_5'UTR|DMRT2_uc010mgz.2_5'UTR|DMRT2_uc003zgy.3_Intron|DMRT2_uc003zhb.3_Missense_Mutation_p.E23K|DMRT2_uc011llt.1_Missense_Mutation_p.E23K|DMRT2_uc011llu.1_Missense_Mutation_p.E23K|DMRT2_uc011llv.1_Missense_Mutation_p.E23K	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	23					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		CCTGGAGCTGGAAGAGGACGT	0.403													7	0					0	0	0.00198382	0	0
FREM1	158326	broad.mit.edu	37	9	14857659	14857659	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:14857659G>A	uc003zlm.2	-	5	1310	c.720C>T	c.(718-720)TTC>TTT	p.F240F	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	240					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CCATCAGCAGGAACTCCTCAC	0.468													21	18					0	0	0.00188189	0	0
IFNA8	3445	broad.mit.edu	37	9	21409388	21409388	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:21409388C>T	uc003zpc.1	+	1	243	c.213C>T	c.(211-213)TTC>TTT	p.F71F		NM_002170	NP_002161	P32881	IFNA8_HUMAN	interferon, alpha 8 precursor	71					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		ATAAACAGTTCCAGAAGGCTC	0.483													35	22					0	0	0.000491102	0	0
TAF1L	138474	broad.mit.edu	37	9	32632764	32632764	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:32632764G>A	uc003zrg.1	-	1	2904	c.2814C>T	c.(2812-2814)TTC>TTT	p.F938F	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	938					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCTTCATCTGGAAATCTTCCT	0.468													31	15					0	0	0.0024448	0	0
PIGO	84720	broad.mit.edu	37	9	35091524	35091524	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:35091524G>A	uc003zwd.2	-	7	2756	c.2360C>T	c.(2359-2361)CCC>CTC	p.P787L	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Missense_Mutation_p.P350L	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	787					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TTGAGAAGTGGGGGGGCCTGA	0.607													22	13					0	0	0.00047179	0	0
CCIN	881	broad.mit.edu	37	9	36170052	36170052	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:36170052C>T	uc003zzb.3	+	1	664	c.553C>T	c.(553-555)CGT>TGT	p.R185C		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	185	BACK.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			CCGCCTGCTCCGTGATGAAAA	0.532													24	12					0	0	0.00047179	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39171442	39171442	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:39171442G>A	uc004abi.2	-	8	1496	c.1257C>T	c.(1255-1257)TTC>TTT	p.F419F	CNTNAP3_uc004abj.2_Silent_p.F419F|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Silent_p.F419F|CNTNAP3_uc011lqs.1_Silent_p.F419F|CNTNAP3_uc004abl.1_Silent_p.F331F	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	419	Extracellular (Potential).|Laminin G-like 2.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAAGAGGACGAAACTCCCTG	0.483													35	17					0	0	0.000692331	0	0
C9orf135	138255	broad.mit.edu	37	9	72471531	72471531	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:72471531G>A	uc004ahl.2	+	3	387	c.322G>A	c.(322-324)GAA>AAA	p.E108K	C9orf135_uc011lrw.1_5'UTR|C9orf135_uc010moq.2_5'UTR|C9orf135_uc011lrx.1_RNA|C9orf135_uc010mop.2_Missense_Mutation_p.E108K	NM_001010940	NP_001010940	Q5VTT2	CI135_HUMAN	hypothetical protein LOC138255	108	Extracellular (Potential).					integral to membrane				ovary(1)	1						AGAATGGGTTGAAATGAAGAG	0.338													19	13					0	0	0.00152264	0	0
TRPM6	140803	broad.mit.edu	37	9	77343228	77343228	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:77343228C>A	uc004ajl.1	-	38	6100	c.5862G>T	c.(5860-5862)TTG>TTT	p.L1954F	TRPM6_uc004ajk.1_Missense_Mutation_p.L1949F|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.L905F|TRPM6_uc010mpd.1_Missense_Mutation_p.L787F|TRPM6_uc010mpe.1_Missense_Mutation_p.L501F|TRPM6_uc004ajj.1_Missense_Mutation_p.L910F	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1954	ATP (By similarity).|Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CATCTTCCCCCAAATTGGCCG	0.423													12	13					0.000978159	0.00402107	0.000978159	1	0
PRUNE2	158471	broad.mit.edu	37	9	79323953	79323953	+	Nonsense_Mutation	SNP	G	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:79323953G>C	uc010mpk.2	-	8	3361	c.3237C>G	c.(3235-3237)TAC>TAG	p.Y1079*		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	1079					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TGGGGTCGTCGTAACTGGACT	0.517													37	29					0	0	0.000509022	0	0
RASEF	158158	broad.mit.edu	37	9	85640753	85640753	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:85640753T>C	uc004amo.1	-	2	776	c.515A>G	c.(514-516)AAC>AGC	p.N172S		NM_152573	NP_689786	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	172					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding			upper_aerodigestive_tract(1)|lung(1)|breast(1)	3						ACGGATGAAGTTCTTTATAAC	0.393													57	37					0	0	0.000781405	0	0
ROR2	4920	broad.mit.edu	37	9	94488852	94488852	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:94488852C>T	uc004arj.1	-	8	1556	c.1357G>A	c.(1357-1359)GAA>AAA	p.E453K	ROR2_uc004ari.1_Missense_Mutation_p.E313K|ROR2_uc004ark.2_3'UTR	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	453	Cytoplasmic (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						AGGGGCATTTCCATGTCTTGG	0.537													17	16					0	0	0.00188189	0	0
PTCH1	5727	broad.mit.edu	37	9	98231211	98231211	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:98231211G>A	uc004avk.3	-	14	2260	c.2072C>T	c.(2071-2073)ACC>ATC	p.T691I	PTCH1_uc010mro.2_Missense_Mutation_p.T540I|PTCH1_uc010mrp.2_Missense_Mutation_p.T540I|PTCH1_uc010mrq.2_Missense_Mutation_p.T540I|PTCH1_uc004avl.3_Missense_Mutation_p.T540I|PTCH1_uc010mrr.2_Missense_Mutation_p.T625I|PTCH1_uc004avm.3_Missense_Mutation_p.T690I|PTCH1_uc010mrs.1_Missense_Mutation_p.T359I	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	691	Cytoplasmic (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.T691I(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CTGTGTCACGGTGACGGGCTG	0.642									Basal_Cell_Nevus_syndrome				17	11					0	0	0.000566183	0	0
OR13C2	392376	broad.mit.edu	37	9	107367211	107367211	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:107367211C>T	uc011lvq.1	-	1	698	c.698G>A	c.(697-699)GGG>GAG	p.G233E		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTTGCTTCTCCCCTCGGAAGA	0.413													35	10					0	0	0.000814825	0	0
SVEP1	79987	broad.mit.edu	37	9	113192603	113192603	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:113192603G>A	uc010mtz.2	-	33	5818	c.5481C>T	c.(5479-5481)ATC>ATT	p.I1827I	SVEP1_uc010mty.2_5'Flank	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1827	Sushi 7.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						CCAAACATGTGATTTTGGTTA	0.398													10	6					0	0	0.000978159	0	0
C9orf84	158401	broad.mit.edu	37	9	114508622	114508622	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:114508622C>T	uc004bfr.2	-	8	914	c.779G>A	c.(778-780)GGA>GAA	p.G260E	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfs.1_Missense_Mutation_p.G324E|C9orf84_uc004bfq.2_Missense_Mutation_p.G221E|C9orf84_uc010mug.2_Missense_Mutation_p.G206E	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	260										ovary(2)	2						TTCTAACTCTCCTGGAATATA	0.239													21	12					0	0	0.00121646	0	0
DEC1	50514	broad.mit.edu	37	9	118162656	118162656	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:118162656G>A	uc004bjk.1	+	6	551	c.32G>A	c.(31-33)TGG>TAG	p.W11*	DEC1_uc004bjl.1_Intron	NM_017418	NP_059114	Q9P2X7	DEC1_HUMAN	deleted in esophageal cancer 1	11					negative regulation of cell proliferation					ovary(1)	1						gctgggaagtggaagagcatt	0.025													20	16					0	0	0.00152264	0	0
DEC1	50514	broad.mit.edu	37	9	118163567	118163567	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:118163567G>A	uc004bjk.1	+	7	702	c.183G>A	c.(181-183)AGG>AGA	p.R61R	DEC1_uc004bjl.1_RNA	NM_017418	NP_059114	Q9P2X7	DEC1_HUMAN	deleted in esophageal cancer 1	61					negative regulation of cell proliferation					ovary(1)	1						CTCTTGCCAGGCCCAAGGCTG	0.353													27	11					0	0	0.00209593	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123215998	123215998	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:123215998G>A	uc004bkf.2	-	21	2710	c.2529C>T	c.(2527-2529)TCC>TCT	p.S843S	CDK5RAP2_uc004bke.2_Silent_p.S128S|CDK5RAP2_uc004bkg.2_Silent_p.S843S|CDK5RAP2_uc011lxw.1_Silent_p.S108S|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Silent_p.S108S|CDK5RAP2_uc011lya.1_Silent_p.S108S|CDK5RAP2_uc004bkh.1_Intron|CDK5RAP2_uc004bki.2_Silent_p.S610S	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	843					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						CATGTGGCTTGGAAAATGAGT	0.463													39	29					0	0	0.00222228	0	0
CERCAM	51148	broad.mit.edu	37	9	131198100	131198100	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:131198100C>T	uc004buz.3	+	12	2102	c.1704C>T	c.(1702-1704)TCC>TCT	p.S568S	CERCAM_uc004buy.1_Silent_p.S490S|CERCAM_uc010mxz.2_Silent_p.S490S	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	568					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						GGAGCGGCTCCCAAAAGACCC	0.677													7	4					0	0	0.000157383	0	0
C9orf98	158067	broad.mit.edu	37	9	135750555	135750555	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:135750555G>A	uc004cbu.1	-	2	672	c.116C>T	c.(115-117)CCC>CTC	p.P39L	C9orf98_uc010mzx.1_RNA|C9orf98_uc004cbv.1_Intron	NM_152572	NP_689785	Q96MA6	KAD8_HUMAN	putative adenylate kinase-like protein C9orf98	39						cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity				0				OV - Ovarian serous cystadenocarcinoma(145;4.89e-06)|Epithelial(140;0.00016)		GGGATCTTCGGGCTGGTGGAT	0.488													10	17					0	0	0.000978159	0	0
GTF3C5	9328	broad.mit.edu	37	9	135919250	135919250	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:135919250C>T	uc004cci.3	+	3	846	c.509C>T	c.(508-510)CCA>CTA	p.P170L	GTF3C5_uc010mzz.2_Missense_Mutation_p.P45L|GTF3C5_uc004ccj.3_Missense_Mutation_p.P170L	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5	170						transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		TACATCCCCCCACCCATCTTC	0.617													11	15					0	0	0.000978159	0	0
C9orf96	169436	broad.mit.edu	37	9	136259421	136259421	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:136259421C>T	uc004cdk.2	+	8	648	c.587C>T	c.(586-588)CCC>CTC	p.P196L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	196	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CCAACAGACCCCTTTCGTAAG	0.567													31	27					0	0	0.00178596	0	0
TRAF2	7186	broad.mit.edu	37	9	139815663	139815663	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:139815663C>T	uc010nbu.2	+	10	1307	c.1134C>T	c.(1132-1134)TCC>TCT	p.S378S	TRAF2_uc004cjv.2_Silent_p.S378S|TRAF2_uc011mek.1_Silent_p.S367S|TRAF2_uc010nbw.2_Silent_p.S353S	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	TNF receptor-associated factor 2	378	MATH.				activation of caspase activity|activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|protein autoubiquitination|protein homotrimerization|protein K63-linked ubiquitination|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)|skin(1)	4	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CCATCTTCTCCCCAGGTGTGG	0.602													12	6					0	0	0.000219431	0	0
SLC34A3	142680	broad.mit.edu	37	9	140126205	140126206	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:140126205_140126206GG>AA	uc004cmf.1	+	2	237_238	c.51_52GG>AA	c.(49-54)GCGGTT>GCAATT	p.V18I	SLC34A3_uc004cmc.1_5'UTR|SLC34A3_uc004cmd.1_Missense_Mutation_p.V18I|SLC34A3_uc011met.1_Missense_Mutation_p.V18I	NM_080877	NP_543153	Q8N130	NPT2C_HUMAN	solute carrier family 34 (sodium phosphate),	18	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CTCTGGACGCGGTTGACCTAGT	0.644													31	20					0	0	6.4e-05	0	0
CACNA1B	774	broad.mit.edu	37	9	140991008	140991008	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr9:140991008C>T	uc004cog.2	+	36	5312	c.5167C>T	c.(5167-5169)CCT>TCT	p.P1723S	CACNA1B_uc004coi.2_Missense_Mutation_p.P935S|CACNA1B_uc004cok.1_RNA|CACNA1B_uc010ncp.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1723	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CATCCTAGGTCCTCACCACTT	0.557													27	9					0	0	0.001512	0	0
IL3RA	3563	broad.mit.edu	37	X	1471298	1471298	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:1471298G>A	uc004cps.2	+	6	864	c.515G>A	c.(514-516)CGA>CAA	p.R172Q	IL3RA_uc011mhd.1_Missense_Mutation_p.R94Q	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	172	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GACATCTCTCGACTCTCCAGC	0.532													46	86					0	0	0.000781405	0	0
MXRA5	25878	broad.mit.edu	37	X	3228042	3228042	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:3228042C>T	uc004crg.3	-	7	8359	c.8202G>A	c.(8200-8202)CGG>CGA	p.R2734R		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2734	Ig-like C2-type 12.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CGCTGGTGATCCGGGGAGGAT	0.597													15	28					0	0	0.00074312	0	0
MXRA5	25878	broad.mit.edu	37	X	3238523	3238523	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:3238523T>A	uc004crg.3	-	5	5360	c.5203A>T	c.(5203-5205)AAC>TAC	p.N1735Y		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1735						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AGAGTCTTGTTGGTAAAGAAA	0.463													12	24					0	0	0.000978159	0	0
MXRA5	25878	broad.mit.edu	37	X	3241849	3241849	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:3241849G>A	uc004crg.3	-	5	2034	c.1877C>T	c.(1876-1878)TCA>TTA	p.S626L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	626	Ig-like C2-type 2.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTATACATGTGATGTGTTAGC	0.453													22	31					0	0	0.00188189	0	0
MXRA5	25878	broad.mit.edu	37	X	3248289	3248289	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:3248289C>T	uc004crg.3	-	4	636	c.479G>A	c.(478-480)GGA>GAA	p.G160E		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	160	LRR 5.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GAGGAGATTTCCTTCCAAATG	0.468													13	24					0	0	0.000308642	0	0
FAM9B	171483	broad.mit.edu	37	X	8997363	8997363	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:8997363T>A	uc011mhu.1	-	5	467	c.378A>T	c.(376-378)GAA>GAT	p.E126D	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Missense_Mutation_p.E166D	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	126						nucleus					0		Hepatocellular(5;0.219)				Gttcttcctcttctccctctt	0.308													13	9					0	0	0.00136819	0	0
SHROOM2	357	broad.mit.edu	37	X	9900704	9900704	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:9900704G>A	uc004csu.1	+	6	3471	c.3381G>A	c.(3379-3381)CCG>CCA	p.P1127P	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1127					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				AGGACACCCCGAAGGCCACTG	0.657													10	19					0	0	0.000442599	0	0
SHROOM2	357	broad.mit.edu	37	X	9900726	9900726	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:9900726G>A	uc004csu.1	+	6	3493	c.3403G>A	c.(3403-3405)GGA>AGA	p.G1135R	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1135					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CTGTGAGCGTGGAAGCCAGCA	0.652													10	22					0	0	0.000442599	0	0
WWC3	55841	broad.mit.edu	37	X	10096186	10096186	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:10096186C>T	uc004csx.3	+	16	2463	c.2265C>T	c.(2263-2265)TCC>TCT	p.S755S	WWC3_uc010nds.2_Silent_p.S419S|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	755										ovary(4)	4						ACACCATCTCCATCTCCGGCA	0.587													19	35					0	0	0.00229938	0	0
ARHGAP6	395	broad.mit.edu	37	X	11160413	11160413	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:11160413C>T	uc004cup.1	-	12	3070	c.2197G>A	c.(2197-2199)GAT>AAT	p.D733N	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cum.1_Missense_Mutation_p.D530N|ARHGAP6_uc004cun.1_Missense_Mutation_p.D553N	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	733					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						CCCCAGATATCGAAAGGCTCC	0.313													40	85					0	0	0.000781405	0	0
TXLNG	55787	broad.mit.edu	37	X	16836894	16836894	+	Nonsense_Mutation	SNP	C	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:16836894C>G	uc004cxq.1	+	2	351	c.300C>G	c.(298-300)TAC>TAG	p.Y100*	TXLNG_uc010ney.1_Intron	NM_018360	NP_060830	Q9NUQ3	TXLNG_HUMAN	gamma-taxilin	100					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane				lung(1)	1						GCCCAGCATACTGCACGCAAG	0.458													3	115					0	0	6.4e-05	0	0
NHS	4810	broad.mit.edu	37	X	17743841	17743841	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:17743841G>A	uc004cxx.2	+	6	1890	c.1552G>A	c.(1552-1554)GAA>AAA	p.E518K	NHS_uc011mix.1_Missense_Mutation_p.E539K|NHS_uc004cxy.2_Missense_Mutation_p.E362K|NHS_uc004cxz.2_Missense_Mutation_p.E341K|NHS_uc004cya.2_Missense_Mutation_p.E241K	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	518						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					GGGTGACCATGAAAGAACCCC	0.557													22	43					0	0	0.000720815	0	0
GPR64	10149	broad.mit.edu	37	X	19042051	19042051	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:19042051G>A	uc004cyx.2	-	12	650	c.486C>T	c.(484-486)AAC>AAT	p.N162N	GPR64_uc004cyy.2_Silent_p.N159N|GPR64_uc004cyz.2_Silent_p.N148N|GPR64_uc004czb.2_Silent_p.N162N|GPR64_uc004czc.2_Silent_p.N146N|GPR64_uc004czd.2_Silent_p.N138N|GPR64_uc004cze.2_Silent_p.N132N|GPR64_uc004czf.2_Silent_p.N124N|GPR64_uc004cza.2_Silent_p.N140N|GPR64_uc004cyw.2_Silent_p.N146N|GPR64_uc010nfj.2_Silent_p.N132N	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	162	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					GCAGGGTTTTGTTGAGCTCTG	0.358													22	37					0	0	0.000878237	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212306	26212306	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:26212306C>T	uc004dbr.2	+	2	492	c.343C>T	c.(343-345)CCT>TCT	p.P115S	MAGEB6_uc010ngc.1_Intron	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	115	Ser-rich.									ovary(3)	3						CACTGGCTCTCCTGATGCAGG	0.542													30	58					0	0	0.000491102	0	0
FTHL17	53940	broad.mit.edu	37	X	31089734	31089734	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:31089734G>A	uc004dcl.1	-	1	440	c.337C>T	c.(337-339)CAG>TAG	p.Q113*		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	113	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						AGCAGGCTCTGGTTGACGTTC	0.607													24	36					0	0	0.000878237	0	0
FAM47A	158724	broad.mit.edu	37	X	34148503	34148503	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:34148503A>T	uc004ddg.2	-	1	1926	c.1893T>A	c.(1891-1893)TTT>TTA	p.F631L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	631										ovary(4)|central_nervous_system(1)	5						ACTTGGGGGTAAAGTCAAACA	0.438													30	43					0	0	0.001512	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820931	35820931	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:35820931G>A	uc010ngt.1	+	2	897	c.618G>A	c.(616-618)CTG>CTA	p.L206L		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	206	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						CTGGCCTCCTGATAATTGTCC	0.522													18	35					0	0	0.000375601	0	0
RPGR	6103	broad.mit.edu	37	X	38128894	38128894	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:38128894G>A	uc004deb.2	-	19	2601	c.2433C>T	c.(2431-2433)TCC>TCT	p.S811S	RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_000328	NP_000319	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform A	1016					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GTATTGTACAGGATTTTGATC	0.294													31	73					0	0	0.000692331	0	0
USP9X	8239	broad.mit.edu	37	X	41088904	41088904	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:41088904C>T	uc004dfb.2	+	43	7936	c.7303C>T	c.(7303-7305)CCT>TCT	p.P2435S	USP9X_uc004dfc.2_Missense_Mutation_p.P2435S	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	2435					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TACTGGCAATCCTCAGTACAC	0.428													25	42					0	0	0.000586117	0	0
MAOB	4129	broad.mit.edu	37	X	43661466	43661466	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:43661466C>T	uc004dfz.3	-	5	605	c.429G>A	c.(427-429)TGG>TGA	p.W143*	MAOB_uc011mkx.1_Nonsense_Mutation_p.W127*|MAOB_uc011mky.1_Nonsense_Mutation_p.W127*	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	143	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	TCATGTTGTCCCACTCTTCTG	0.438													7	14					0	0	0.000274275	0	0
SLC9A7	84679	broad.mit.edu	37	X	46521567	46521567	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:46521567C>T	uc004dgu.1	-	7	933	c.925G>A	c.(925-927)GGA>AGA	p.G309R	SLC9A7_uc004dgv.1_Missense_Mutation_p.G309R	NM_032591	NP_115980	Q96T83	SL9A7_HUMAN	solute carrier family 9, member 7	309					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			ovary(2)	2						GTGTTCAGTCCCGCTGGCTGG	0.408													6	20					0	0	0.000157383	0	0
PHF16	9767	broad.mit.edu	37	X	46913781	46913781	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:46913781G>A	uc004dgx.2	+	9	1245	c.1194G>A	c.(1192-1194)CAG>CAA	p.Q398Q	PHF16_uc004dgy.2_Silent_p.Q398Q	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	398					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						TGCGGGCACAGAAGCTTCGGG	0.537													17	31					0	0	0.000422831	0	0
ARAF	369	broad.mit.edu	37	X	47426163	47426163	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:47426163A>T	uc011mlq.1	+	7	816	c.683A>T	c.(682-684)GAC>GTC	p.D228V	ARAF_uc011mln.1_Intron|ARAF_uc011mlo.1_Missense_Mutation_p.D94V|ARAF_uc011mlp.1_Missense_Mutation_p.D228V|ARAF_uc004dic.1_Missense_Mutation_p.D9V	NM_001654	NP_001645	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene	228					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity			large_intestine(3)|lung(2)|ovary(1)|skin(1)	7					Adenosine triphosphate(DB00171)	GCCCCCATGGACTCCAACCTC	0.627													19	28					0	0	0.00229938	0	0
ELK1	2002	broad.mit.edu	37	X	47500833	47500833	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:47500833G>A	uc004dik.3	-	3	330	c.8C>T	c.(7-9)CCA>CTA	p.P3L	ELK1_uc010nhv.2_Missense_Mutation_p.P3L|ELK1_uc010nhw.2_5'UTR|ELK1_uc004dil.3_RNA	NM_001114123	NP_001107595	P19419	ELK1_HUMAN	ELK1 protein	3					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						CGTCACAGATGGGTCCATCGC	0.587													3	8					0	0	6.4e-05	0	0
WAS	7454	broad.mit.edu	37	X	48542280	48542280	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:48542280G>A	uc004dkm.3	+	1	95	c.38G>A	c.(37-39)CGA>CAA	p.R13Q		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	13					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				CCCGGGGGCCGAGGAGCACCA	0.597			Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				14	30					0	0	0.000308642	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49034474	49034474	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:49034474G>A	uc004dmy.1	-	7	849	c.823C>T	c.(823-825)CAC>TAC	p.H275Y	PRICKLE3_uc011mmv.1_Missense_Mutation_p.H207Y|PRICKLE3_uc011mmw.1_Missense_Mutation_p.H194Y|PRICKLE3_uc011mmx.1_Missense_Mutation_p.H237Y|PRICKLE3_uc011mmy.1_Missense_Mutation_p.H262Y	NM_006150	NP_006141	O43900	PRIC3_HUMAN	LIM domain only 6	275	LIM zinc-binding 2.						protein binding|zinc ion binding			breast(1)	1						CAGCAGAAGTGATCCATGTGC	0.632													6	14					0	0	0.00116845	0	0
CACNA1F	778	broad.mit.edu	37	X	49081431	49081431	+	Silent	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:49081431A>G	uc004dnb.2	-	14	1764	c.1702T>C	c.(1702-1704)TTG>CTG	p.L568L	CACNA1F_uc010nip.2_Silent_p.L557L	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	568	II.|Helical; Name=S2 of repeat II; (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	AGACAGAGCAACACTTTGTTG	0.537													4	6					0	0	0.000602214	0	0
CCDC22	28952	broad.mit.edu	37	X	49099887	49099887	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:49099887G>A	uc004dnd.1	+	6	829	c.673G>A	c.(673-675)GAT>AAT	p.D225N	CCDC22_uc011mna.1_Missense_Mutation_p.D225N|CCDC22_uc004dnc.1_RNA	NM_014008	NP_054727	O60826	CCD22_HUMAN	coiled-coil domain containing 22	225										central_nervous_system(1)	1						CCGGCCAGGGGATGAGGACTG	0.677													3	4					0	0	6.4e-05	0	0
AKAP4	8852	broad.mit.edu	37	X	49955652	49955652	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:49955652C>T	uc004dow.1	-	6	2640	c.2516G>A	c.(2515-2517)GGA>GAA	p.G839E	AKAP4_uc004dov.1_Missense_Mutation_p.G456E|AKAP4_uc010njp.1_Missense_Mutation_p.G661E|AKAP4_uc004dou.1_Missense_Mutation_p.G830E	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	839					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					GGCCACCTTTCCCACAGCTTC	0.527													18	57					0	0	0.00074312	0	0
AKAP4	8852	broad.mit.edu	37	X	49958744	49958744	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:49958744G>A	uc004dow.1	-	5	744	c.620C>T	c.(619-621)TCC>TTC	p.S207F	AKAP4_uc004dov.1_Intron|AKAP4_uc010njp.1_Missense_Mutation_p.S29F|AKAP4_uc004dou.1_Missense_Mutation_p.S198F	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	207					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					TCCATCAGGGGAAATGACTGC	0.443													89	140					0	0	0.000781405	0	0
SHROOM4	57477	broad.mit.edu	37	X	50376200	50376200	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:50376200T>A	uc004dpe.2	-	4	2899	c.2873A>T	c.(2872-2874)AAA>ATA	p.K958I	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.K842I	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	958					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CTTCCTGGGTTTCCAAGTGTT	0.483													5	11					0	0	0.00198382	0	0
SHROOM4	57477	broad.mit.edu	37	X	50376392	50376392	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:50376392C>T	uc004dpe.2	-	4	2707	c.2681G>A	c.(2680-2682)GGA>GAA	p.G894E	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.G778E	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	894	Cys-rich.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					GACTAGAGCTCCTTGAACACT	0.448													17	28					0	0	0.000422831	0	0
GSPT2	23708	broad.mit.edu	37	X	51487254	51487254	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:51487254G>A	uc004dpl.2	+	1	758	c.532G>A	c.(532-534)GAA>AAA	p.E178K		NM_018094	NP_060564	Q8IYD1	ERF3B_HUMAN	peptide chain release factor 3	178					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)	1	Ovarian(276;0.236)					AAGTGGCCAGGAAATGATGGA	0.478													4	19					0	0	0.000602214	0	0
HUWE1	10075	broad.mit.edu	37	X	53575230	53575230	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:53575230A>T	uc004dsp.2	-	68	10442	c.10040T>A	c.(10039-10041)TTT>TAT	p.F3347Y	HUWE1_uc004dsn.2_Missense_Mutation_p.F2155Y	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3347					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GTGGCTGGGAAATACCTGCCG	0.532													7	13					0	0	0.00198382	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62875602	62875602	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:62875602C>T	uc004dvl.2	-	8	1911	c.1072G>A	c.(1072-1074)GAC>AAC	p.D358N	ARHGEF9_uc004dvj.1_Missense_Mutation_p.D247N|ARHGEF9_uc004dvk.1_Missense_Mutation_p.D176N|ARHGEF9_uc011mos.1_Missense_Mutation_p.D337N|ARHGEF9_uc004dvm.1_Missense_Mutation_p.D337N|ARHGEF9_uc011mot.1_Missense_Mutation_p.D305N|ARHGEF9_uc004dvn.2_Missense_Mutation_p.D365N	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	358	PH.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						TACAGGATGTCTCTCCGGATT	0.468													60	108					0	0	0.000781405	0	0
SLC7A3	84889	broad.mit.edu	37	X	70148084	70148084	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:70148084C>T	uc004dyn.2	-	5	889	c.731G>A	c.(730-732)GGA>GAA	p.G244E	SLC7A3_uc004dyo.2_Missense_Mutation_p.G244E	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	244	Helical; Name=6; (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AGGCACAAATCCTCCAGAGCC	0.493													6	15					0	0	0.000157383	0	0
MED12	9968	broad.mit.edu	37	X	70338619	70338619	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:70338619G>A	uc004dyy.2	+	1	214	c.15G>A	c.(13-15)GGG>GGA	p.G5G	MED12_uc011mpq.1_Silent_p.G5G|MED12_uc004dyz.2_Silent_p.G5G|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	5					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					CGGCCTTCGGGATCTTGAGCT	0.667													9	5					0	0	0.000673444	0	0
OGT	8473	broad.mit.edu	37	X	70779460	70779460	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:70779460C>T	uc004eaa.1	+	14	2001	c.1784C>T	c.(1783-1785)CCA>CTA	p.P595L	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.P585L|OGT_uc004eac.2_Missense_Mutation_p.P456L|OGT_uc004ead.2_Missense_Mutation_p.P214L	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	595					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					GCCCTGAGCCCAGACGATGGC	0.403													9	28					0	0	0.000978159	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427528	71427528	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:71427528C>T	uc004eaq.1	-	2	1186	c.1089G>A	c.(1087-1089)AGG>AGA	p.R363R	PIN4_uc004eao.1_Intron|ERCC6L_uc004eap.1_Silent_p.R240R	NM_017669	NP_060139	Q2NKX8	ERC6L_HUMAN	excision repair protein ERCC6-like	363					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			ovary(3)	3	Renal(35;0.156)					AATCATTTTTCCTGGAAAGGG	0.363													51	106					0	0	0.000781405	0	0
RLIM	51132	broad.mit.edu	37	X	73812727	73812727	+	Silent	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:73812727T>A	uc004ebu.2	-	5	713	c.423A>T	c.(421-423)ATA>ATT	p.I141I	RLIM_uc004ebw.2_Silent_p.I141I	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	141					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GGTTAACATTTATCTCTAAAC	0.408													67	112					0	0	0.000781405	0	0
UPRT	139596	broad.mit.edu	37	X	74494208	74494208	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:74494208G>A	uc004ecb.1	+	1	248	c.119G>A	c.(118-120)GGG>GAG	p.G40E	UPRT_uc010nlu.1_Missense_Mutation_p.G40E|UPRT_uc004ecc.1_RNA|UPRT_uc004ecd.1_Missense_Mutation_p.G40E|UPRT_uc004ece.1_5'Flank	NM_145052	NP_659489	Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog	40					nucleoside metabolic process	cytoplasm|nucleus					0						GACCACGCAGGGGGAAACAGA	0.642													7	23					0	0	0.00198382	0	0
CXorf26	51260	broad.mit.edu	37	X	75397606	75397606	+	Missense_Mutation	SNP	A	G	G			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:75397606A>G	uc004ecl.1	+	6	768	c.565A>G	c.(565-567)AAT>GAT	p.N189D		NM_016500	NP_057584	Q9BVG4	CX026_HUMAN	hypothetical protein LOC51260	189											0						gaacaccaagaatggaggaga	0.055													7	11					0	0	0.00198382	0	0
TAF9B	51616	broad.mit.edu	37	X	77393565	77393565	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:77393565T>A	uc004eda.2	-	3	235	c.164A>T	c.(163-165)AAA>ATA	p.K55I		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	55					negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						CGAATAAATTTTTGCATCATC	0.368													63	101					0	0	0.000781405	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913641	77913641	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:77913641C>T	uc004edc.1	-	2	573	c.277G>A	c.(277-279)GAT>AAT	p.D93N		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	93	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						GGTAGAAGATCCTGTGGCTCT	0.647													7	15					0	0	0.000157383	0	0
LPAR4	2846	broad.mit.edu	37	X	78011169	78011169	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:78011169T>C	uc010nme.2	+	2	1208	c.803T>C	c.(802-804)GTC>GCC	p.V268A		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	268	Helical; Name=6; (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TACAACTCTGTCCTCTTCTTG	0.413													17	25					0	0	0.000422831	0	0
BRWD3	254065	broad.mit.edu	37	X	79937548	79937548	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:79937548G>A	uc004edt.2	-	39	4706	c.4443C>T	c.(4441-4443)GAC>GAT	p.D1481D	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Silent_p.D1077D|BRWD3_uc004edp.2_Silent_p.D1310D|BRWD3_uc004edq.2_Silent_p.D1077D|BRWD3_uc010nmj.1_Silent_p.D1077D|BRWD3_uc004edr.2_Silent_p.D1151D|BRWD3_uc004eds.2_Silent_p.D1077D|BRWD3_uc004edu.2_Silent_p.D1151D|BRWD3_uc004edv.2_Silent_p.D1077D|BRWD3_uc004edw.2_Silent_p.D1077D|BRWD3_uc004edx.2_Silent_p.D1077D|BRWD3_uc004edy.2_Silent_p.D1077D|BRWD3_uc004edz.2_Silent_p.D1151D|BRWD3_uc004eea.2_Silent_p.D1151D|BRWD3_uc004eeb.2_Silent_p.D1077D	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1481										ovary(4)	4						AGGTATTCTGGTCATTTTTAG	0.363													30	60					0	0	0.00111076	0	0
SH3BGRL	6451	broad.mit.edu	37	X	80532515	80532515	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:80532515C>T	uc004eef.2	+	2	475	c.78C>T	c.(76-78)TTC>TTT	p.F26F	SH3BGRL_uc011mqs.1_RNA|SH3BGRL_uc010nml.2_RNA|SH3BGRL_uc010nmm.2_Silent_p.F63F|SH3BGRL_uc010nmn.2_Silent_p.F63F	NM_003022	NP_003013	O75368	SH3L1_HUMAN	SH3 domain binding glutamic acid-rich protein	26						cytoplasm|nucleus	SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		all_lung(315;5.94e-05)				TGCTTGGTTTCCTAGAAGCCA	0.378													13	39					0	0	0.000422831	0	0
SATL1	340562	broad.mit.edu	37	X	84349220	84349220	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:84349220C>T	uc011mqx.1	-	4	1790	c.1790G>A	c.(1789-1791)GGA>GAA	p.G597E	SATL1_uc004een.2_Missense_Mutation_p.G597E	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	410	N-acetyltransferase.						N-acetyltransferase activity			breast(2)	2						CATGGCAAATCCAACAGTCAG	0.403													30	60					0	0	0.000491102	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090558	91090558	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:91090558T>C	uc004efk.1	+	1	900	c.55T>C	c.(55-57)TTC>CTC	p.F19L	PCDH11X_uc004efl.1_Missense_Mutation_p.F19L|PCDH11X_uc004efo.1_Missense_Mutation_p.F19L|PCDH11X_uc010nmv.1_Missense_Mutation_p.F19L|PCDH11X_uc004efm.1_Missense_Mutation_p.F19L|PCDH11X_uc004efn.1_Missense_Mutation_p.F19L|PCDH11X_uc004efh.1_Missense_Mutation_p.F19L|PCDH11X_uc004efj.1_Missense_Mutation_p.F19L	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	19					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						ATGCGTGGTGTTCCACTCTGG	0.483													23	36					0	0	0.00047179	0	0
TMEM35	59353	broad.mit.edu	37	X	100349697	100349697	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:100349697C>T	uc004egw.2	+	2	412	c.256C>T	c.(256-258)CCC>TCC	p.P86S		NM_021637	NP_067650	Q53FP2	TMM35_HUMAN	transmembrane protein 35	86						cytoplasmic membrane-bounded vesicle|integral to membrane|peroxisomal membrane					0						GCCTGGGCGTCCCAAAGATGT	0.532													53	99					0	0	0.000781405	0	0
TMEM35	59353	broad.mit.edu	37	X	100349720	100349720	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:100349720C>T	uc004egw.2	+	2	435	c.279C>T	c.(277-279)TTC>TTT	p.F93F		NM_021637	NP_067650	Q53FP2	TMM35_HUMAN	transmembrane protein 35	93	Helical; (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|peroxisomal membrane					0						CCAACTTCTTCCTACTGTTGC	0.537													54	94					0	0	0.000781405	0	0
CENPI	2491	broad.mit.edu	37	X	100387404	100387404	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:100387404C>T	uc004egx.2	+	14	1699	c.1429C>T	c.(1429-1431)CAT>TAT	p.H477Y	CENPI_uc011mrg.1_Missense_Mutation_p.H477Y|CENPI_uc004egy.2_Missense_Mutation_p.H477Y	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	477					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						TCTTTTTGACCATCTAGCGCA	0.318													27	91					0	0	0.00127121	0	0
DRP2	1821	broad.mit.edu	37	X	100490968	100490968	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:100490968G>A	uc004egz.2	+	4	606	c.237G>A	c.(235-237)ATG>ATA	p.M79I	DRP2_uc011mrh.1_Missense_Mutation_p.M1I	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	79					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						CACCAGCCATGAATCTGTGTT	0.517													47	117					0	0	0.000781405	0	0
GPRASP1	9737	broad.mit.edu	37	X	101909676	101909676	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:101909676C>T	uc004ejj.3	+	5	1636	c.835C>T	c.(835-837)CCC>TCC	p.P279S	GPRASP1_uc004eji.3_Missense_Mutation_p.P279S|GPRASP1_uc010nod.2_Missense_Mutation_p.P279S	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	279						cytoplasm	protein binding			ovary(1)|lung(1)	2						CAGGGAAGATCCCAATAGCAG	0.473													57	86					0	0	0.000781405	0	0
TCEAL3	85012	broad.mit.edu	37	X	102864578	102864578	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:102864578G>A	uc004ekq.2	+	3	848	c.586G>A	c.(586-588)GAT>AAT	p.D196N	TCEAL3_uc004ekr.2_Missense_Mutation_p.D196N	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GGGCTTACACGATATCCCATA	0.527													26	53					0	0	0.00127121	0	0
NRK	203447	broad.mit.edu	37	X	105150462	105150462	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:105150462C>T	uc004emd.2	+	11	1204	c.901C>T	c.(901-903)CGT>TGT	p.R301C	NRK_uc010npc.1_5'UTR	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	301	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						TTTCCTGTTTCGTCCTACTTC	0.363										HNSCC(51;0.14)			8	12					0	0	0.000157383	0	0
MORC4	79710	broad.mit.edu	37	X	106186394	106186394	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:106186394C>T	uc004emu.3	-	15	1970	c.1727G>A	c.(1726-1728)CGA>CAA	p.R576Q	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.R576Q|MORC4_uc004emw.3_Missense_Mutation_p.R324Q	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	576							ATP binding|zinc ion binding			ovary(1)	1						GAGCCTTCTTCGTTTCTCCAC	0.438													46	82					0	0	0.000781405	0	0
TSC22D3	1831	broad.mit.edu	37	X	106957890	106957890	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:106957890G>A	uc004eng.2	-	3	514	c.264C>T	c.(262-264)TCC>TCT	p.S88S	TSC22D3_uc004enf.2_Silent_p.S31S|TSC22D3_uc004enh.2_Silent_p.S154S|TSC22D3_uc004eni.2_Silent_p.S154S|TSC22D3_uc004enj.2_Silent_p.S154S	NM_004089	NP_004080	Q99576	T22D3_HUMAN	TSC22 domain family, member 3 isoform 2	88	Leucine-zipper.						sequence-specific DNA binding transcription factor activity				0						GCTCTAGCTGGGAGTTCTTCT	0.547													58	113					0	0	0.000781405	0	0
ATG4A	115201	broad.mit.edu	37	X	107393483	107393484	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:107393483_107393484CC>AA	uc004enr.2	+	10	1039_1040	c.916_917CC>AA	c.(916-918)CCA>AAA	p.P306K	ATG4A_uc004ent.2_Missense_Mutation_p.P244K|ATG4A_uc004ens.2_Missense_Mutation_p.P222K|ATG4A_uc011msl.1_Missense_Mutation_p.P160K|ATG4A_uc010npi.2_RNA|ATG4A_uc004enu.2_Missense_Mutation_p.P222K|COL4A6_uc011msm.1_Intron	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	306					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						CCTGCAGTCCCCACAGCGAATG	0.49													8	171					0	0	6.4e-05	0	0
ALG13	79868	broad.mit.edu	37	X	110951410	110951410	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:110951410C>T	uc011msy.1	+	4	573	c.539C>T	c.(538-540)CCT>CTT	p.P180L	ALG13_uc011msw.1_Missense_Mutation_p.P102L|ALG13_uc011msx.1_Missense_Mutation_p.P76L|ALG13_uc011msz.1_Missense_Mutation_p.P102L|ALG13_uc011mta.1_Missense_Mutation_p.P76L|ALG13_uc011mtb.1_Missense_Mutation_p.P76L			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	180					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						GCTACCCATCCTACCTGCACC	0.498													11	37					0	0	0.00136819	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698523	111698523	+	Silent	SNP	T	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:111698523T>C	uc004epo.1	+	3	1008	c.567T>C	c.(565-567)GCT>GCC	p.A189A		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	189							nucleic acid binding|zinc ion binding			ovary(1)	1						AGGCACTAGCTGATCCCAACC	0.468													34	62					0	0	0.0024448	0	0
IL13RA2	3598	broad.mit.edu	37	X	114242621	114242621	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:114242621C>T	uc004epx.2	-	8	996	c.871G>A	c.(871-873)GAA>AAA	p.E291K	IL13RA2_uc010nqd.1_Missense_Mutation_p.E291K	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	291	Extracellular (Potential).|Fibronectin type-III 3.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						GTGTATGTTTCATTTTCAACT	0.363													32	55					0	0	0.0024448	0	0
LRCH2	57631	broad.mit.edu	37	X	114422878	114422878	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:114422878G>A	uc010nqe.2	-	2	436	c.405C>T	c.(403-405)CCC>CCT	p.P135P	LRCH2_uc004epz.2_Silent_p.P135P|RBMXL3_uc011mte.1_5'Flank	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	135	LRR 3.									ovary(1)	1						ATGTTTCAAGGGGTGCAAATA	0.308													15	17					0	0	0.000566183	0	0
SEPT6	23157	broad.mit.edu	37	X	118763465	118763465	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:118763465C>T	uc004erv.2	-	9	1361	c.1096G>A	c.(1096-1098)GAG>AAG	p.E366K	SEPT6_uc010nqk.2_RNA|SEPT6_uc004ers.2_Missense_Mutation_p.E366K|SEPT6_uc004ert.2_Missense_Mutation_p.E366K|SEPT6_uc004eru.2_Missense_Mutation_p.E366K|SEPT6_uc004erw.2_Missense_Mutation_p.E308K|SEPT6_uc011mtv.1_Missense_Mutation_p.E308K|SEPT6_uc011mtw.1_Missense_Mutation_p.E396K	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	366	Potential.				cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding	p.E366E(1)		lung(1)|ovary(1)|prostate(1)|kidney(1)	4						TCAAACTTCTCGTGCAGCTGG	0.537													26	38					0	0	0.00106085	0	0
UPF3B	65109	broad.mit.edu	37	X	118977163	118977163	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:118977163C>T	uc004erz.1	-	5	648	c.571G>A	c.(571-573)GAA>AAA	p.E191K	UPF3B_uc004esa.1_Missense_Mutation_p.E191K	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	191	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						CCTATTAATTCTCTATTTTTT	0.294													43	85					0	0	0.00222228	0	0
STAG2	10735	broad.mit.edu	37	X	123195717	123195717	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:123195717G>A	uc004etz.3	+	16	1970	c.1631G>A	c.(1630-1632)GGA>GAA	p.G544E	STAG2_uc004eua.2_Missense_Mutation_p.G544E|STAG2_uc004eub.2_Missense_Mutation_p.G544E|STAG2_uc004euc.2_Missense_Mutation_p.G544E|STAG2_uc004eud.2_Missense_Mutation_p.G544E|STAG2_uc004eue.2_Missense_Mutation_p.G544E	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	544					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						AGAGGGACAGGAAAAAGGGTA	0.368													32	60					0	0	0.0024448	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128946754	128946754	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:128946754G>A	uc004euv.2	-	7	1086	c.717C>T	c.(715-717)GTC>GTT	p.V239V	ZDHHC9_uc004euw.2_Silent_p.V239V	NM_001008222	NP_001008223	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC domain containing 9	239	Helical; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1						TCAGTCCCACGACGGACCAGA	0.458													62	82					0	0	0.000781405	0	0
IGSF1	3547	broad.mit.edu	37	X	130419413	130419413	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:130419413A>T	uc004ewd.2	-	5	645	c.407T>A	c.(406-408)ATT>AAT	p.I136N	IGSF1_uc004ewe.3_Missense_Mutation_p.I125N|IGSF1_uc004ewf.2_Missense_Mutation_p.I116N|IGSF1_uc004ewg.2_Missense_Mutation_p.I136N	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	136	Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						CTCAGCCTGAATCCAGAAGAT	0.498													33	52					0	0	0.000491102	0	0
SLC9A6	10479	broad.mit.edu	37	X	135104756	135104756	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:135104756C>T	uc004ezj.2	+	11	1342	c.1266C>T	c.(1264-1266)TTC>TTT	p.F422F	SLC9A6_uc004ezk.2_Silent_p.F454F	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	422	Helical; (Potential).				regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TTGCTATTTTCTTGGGAAGAG	0.313													24	49					0	0	0.00106085	0	0
FHL1	2273	broad.mit.edu	37	X	135288748	135288748	+	Splice_Site	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:135288748G>A	uc004ezo.2	+	2	256	c.156_splice	c.e2+1	p.K52_splice	FHL1_uc010nrz.2_Splice_Site_p.K52_splice|FHL1_uc004ezm.2_Intron|FHL1_uc004ezl.2_Splice_Site_p.K52_splice|FHL1_uc004ezq.2_Splice_Site_p.K52_splice|FHL1_uc011mvy.1_Splice_Site_p.K52_splice|FHL1_uc011mvz.1_Splice_Site_p.K52_splice|FHL1_uc004ezn.2_Splice_Site_p.K52_splice|FHL1_uc011mwa.1_Splice_Site_p.K81_splice|FHL1_uc011mwb.1_Splice_Site|FHL1_uc004ezp.2_Splice_Site_p.K68_splice|FHL1_uc004ezr.2_5'Flank	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1						cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					GGACTCCAAGGTAACGGGCAT	0.557													40	71					0	0	0.000589545	0	0
GPR112	139378	broad.mit.edu	37	X	135430106	135430106	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:135430106C>T	uc004ezu.1	+	6	4532	c.4241C>T	c.(4240-4242)TCA>TTA	p.S1414L	GPR112_uc010nsb.1_Missense_Mutation_p.S1209L|GPR112_uc010nsc.1_Missense_Mutation_p.S1181L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1414	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CAGGATACTTCATTTGTAGAT	0.428													38	81					0	0	0.000814825	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135862953	135862953	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:135862953A>C	uc004fab.2	-	1	551	c.89T>G	c.(88-90)TTT>TGT	p.F30C		NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	30	CH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					GGACTTTAAAAACTCCTCCGG	0.433													56	104					0	0	0.000781405	0	0
MCF2	4168	broad.mit.edu	37	X	138669893	138669893	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:138669893G>A	uc004fau.2	-	22	2798	c.2504C>T	c.(2503-2505)TCT>TTT	p.S835F	MCF2_uc004fav.2_Missense_Mutation_p.S851F|MCF2_uc011mwl.1_Missense_Mutation_p.S812F|MCF2_uc010nsh.1_Missense_Mutation_p.S835F|MCF2_uc011mwm.1_Missense_Mutation_p.S796F|MCF2_uc011mwn.1_Missense_Mutation_p.S980F|MCF2_uc004faw.2_Missense_Mutation_p.S895F|MCF2_uc011mwo.1_Missense_Mutation_p.S911F	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	835					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					CTGCTGAAGAGAAATCTGAAA	0.303													48	80					0	0	0.000781405	0	0
SPANXN1	494118	broad.mit.edu	37	X	144337235	144337235	+	Silent	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:144337235G>A	uc004fcb.2	+	2	120	c.120G>A	c.(118-120)TTG>TTA	p.L40L		NM_001009614	NP_001009614	Q5VSR9	SPXN1_HUMAN	SPANX-N1 protein	40											0	Acute lymphoblastic leukemia(192;6.56e-05)					AACCGAGTTTGAAAAAGATGA	0.408													26	45					0	0	0.000586117	0	0
IDS	3423	broad.mit.edu	37	X	148584859	148584859	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:148584859C>T	uc011mxe.1	-	3	599	c.401G>A	c.(400-402)GGA>GAA	p.G134E	IDS_uc011mxf.1_Missense_Mutation_p.G44E|IDS_uc011mxg.1_5'UTR|IDS_uc010nsu.1_Intron|IDS_uc004fcw.3_Intron|IDS_uc011mxh.1_Missense_Mutation_p.G134E|IDS_uc011mxi.1_RNA|IDS_uc011mxj.1_Missense_Mutation_p.G134E	NM_000202	NP_000193	P22304	IDS_HUMAN	iduronate-2-sulfatase isoform a precursor	134			G -> R (in MPS2; severe form).			lysosome	iduronate-2-sulfatase activity|metal ion binding				0	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					AAAGACTTTTCCCACCGACAT	0.537													9	21					0	0	0.000978159	0	0
MIR452	574412	broad.mit.edu	37	X	151128157	151128157	+	RNA	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:151128157C>T	hsa-mir-452|MI0001733	-			c.28C>T			GABRE_uc004ffi.2_Intron|GABRE_uc011myd.1_Intron|GABRE_uc011mye.1_Intron|MIR224_hsa-mir-224|MI0000301_5'Flank																	0						GTCTCAGTTTCCTCTGCAAAC	0.423													45	74					0	0	0.00195071	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303812	151303812	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:151303812G>A	uc004ffk.2	-	5	689	c.281C>T	c.(280-282)CCC>CTC	p.P94L	MAGEA10_uc004ffl.2_Missense_Mutation_p.P94L	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	94											0	Acute lymphoblastic leukemia(192;6.56e-05)					AACGACCGAGGGGGAGGAGCA	0.527													70	177					0	0	0.000781405	0	0
IRAK1	3654	broad.mit.edu	37	X	153278809	153278809	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:153278809G>A	uc004fjs.1	-	12	1694	c.1615C>T	c.(1615-1617)CCC>TCC	p.P539S	IRAK1_uc004fjr.1_Intron|IRAK1_uc004fjt.1_Missense_Mutation_p.P460S|IRAK1_uc010nur.2_Intron	NM_001569	NP_001560	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	539					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			lung(5)|ovary(2)|breast(1)|central_nervous_system(1)	9	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGGAAGGGGGGATGCAGCTG	0.662													22	21					0	0	0.00229938	0	0
PLXNA3	55558	broad.mit.edu	37	X	153694496	153694496	+	Silent	SNP	C	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:153694496C>T	uc004flm.2	+	15	2855	c.2682C>T	c.(2680-2682)ATC>ATT	p.I894I		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	894	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCTAGGATCGTGTGTGAGA	0.677													22	26					0	0	0.00229938	0	0
GAB3	139716	broad.mit.edu	37	X	153908454	153908454	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:153908454A>T	uc004fmj.1	-	9	1647	c.1599T>A	c.(1597-1599)TAT>TAA	p.Y533*	GAB3_uc004fmk.1_Nonsense_Mutation_p.Y534*|GAB3_uc010nve.1_Intron|GAB3_uc004fml.1_Nonsense_Mutation_p.Y153*	NM_080612	NP_542179	Q8WWW8	GAB3_HUMAN	Gab3 protein isoform 2	533										ovary(1)	1	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCAGGGCCAAATAATCTAGGC	0.512													72	139					0	0	0.000781405	0	0
VBP1	7411	broad.mit.edu	37	X	154456711	154456711	+	Silent	SNP	C	T	T	rs11501		TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chrX:154456711C>T	uc004fnc.2	+	4	390	c.331C>T	c.(331-333)CTG>TTG	p.L111L	VBP1_uc004fnd.2_Silent_p.L74L	NM_003372	NP_003363	P61758	PFD3_HUMAN	von Hippel-Lindau binding protein 1	111					'de novo' posttranslational protein folding	nucleus|prefoldin complex	unfolded protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGCAGATAACCTGTATTGCAA	0.398													55	127					0	0	0.000781405	0	0
GNAI3	2773	broad.mit.edu	37	1	110116536	110116537	+	Frame_Shift_Ins	INS	-	TA	TA			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr1:110116536_110116537insTA	uc001dxz.2	+	3	337_338	c.180_181insTA	c.(178-183)GGCTATfs	p.G60fs		NM_006496	NP_006487	P08754	GNAI3_HUMAN	guanine nucleotide binding protein (G protein),	60_61					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			ovary(1)	1		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.046)|Colorectal(144;0.119)|Epithelial(280;0.139)|all cancers(265;0.147)|LUSC - Lung squamous cell carcinoma(189;0.237)		ATGAGGATGGCTATTCAGAGGA	0.342													14	42	---	---	---	---					
ARIH1	25820	broad.mit.edu	37	15	72837239	72837241	+	In_Frame_Del	DEL	GAT	-	-			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:72837239_72837241delGAT	uc002aut.3	+	3	836_838	c.522_524delGAT	c.(520-525)CAGATG>CAG	p.M175del		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	ariadne ubiquitin-conjugating enzyme E2 binding	175					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding				0						GAACACGCCAGATGAATACAAGG	0.414													19	62	---	---	---	---					
SYNM	23336	broad.mit.edu	37	15	99645432	99645432	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr15:99645432delC	uc002bup.2	+	1	147	c.27delC	c.(25-27)GGCfs	p.G9fs	SYNM_uc002buo.2_Frame_Shift_Del_p.G9fs|SYNM_uc002buq.2_RNA	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	9	Head.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TGCAGACGGGCCCCGAGAAGG	0.687													2	4	---	---	---	---					
MINK1	50488	broad.mit.edu	37	17	4790980	4790982	+	In_Frame_Del	DEL	GCA	-	-			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr17:4790980_4790982delGCA	uc010vsl.1	+	12	1321_1323	c.1125_1127delGCA	c.(1123-1128)CTGCAG>CTG	p.Q380del	MINK1_uc010vsk.1_In_Frame_Del_p.Q380del|MINK1_uc010vsm.1_In_Frame_Del_p.Q380del|MINK1_uc010vsn.1_In_Frame_Del_p.Q380del|MINK1_uc010vso.1_In_Frame_Del_p.Q325del|MINK1_uc010vsp.1_5'UTR	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	380					JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						agcagcagctgcagcagcagcag	0.502													2	4	---	---	---	---					
NDUFAF4	29078	broad.mit.edu	37	6	97339122	97339122	+	Frame_Shift_Del	DEL	A	-	-			TCGA-D3-A3C7-06A-11D-A196-08	TCGA-D3-A3C7-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	de7f226f-27a0-4e47-a39d-78b143ba64c5	0769ed5d-994a-4e62-a677-28c028d051f1	g.chr6:97339122delA	uc003pow.2	-	3	476	c.386delT	c.(385-387)TTCfs	p.F129fs	NDUFAF4_uc003pov.2_RNA	NM_014165	NP_054884	Q9P032	NDUF4_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	129					mitochondrial respiratory chain complex I assembly	mitochondrial membrane	calmodulin binding			ovary(1)	1						GGTTTCTGGGAAAAGCTTATG	0.333													24	60	---	---	---	---					
