Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLCNKA	1187	broad.mit.edu	37	1	16356500	16356500	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:16356500C>T	uc001axu.2	+	14	1418	c.1338C>T	c.(1336-1338)GTC>GTT	p.V446V	CLCNKA_uc001axt.2_RNA|CLCNKA_uc001axv.2_Silent_p.V446V|CLCNKA_uc010obw.1_Silent_p.V403V|CLCNKB_uc001axw.3_Intron|CLCNKA_uc010obx.1_Silent_p.V93V|CLCNKA_uc010oby.1_Silent_p.V182V	NM_004070	NP_004061	P51800	CLCKA_HUMAN	chloride channel Ka isoform 1	446					excretion	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.04e-08)|COAD - Colon adenocarcinoma(227;5.46e-06)|BRCA - Breast invasive adenocarcinoma(304;9.02e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00655)|READ - Rectum adenocarcinoma(331;0.0649)	Niflumic Acid(DB04552)	CTCTTGCCGTCGCCTTCCCTG	0.672000													16	13					0	0	0.00188189	0	0
EPHB2	2048	broad.mit.edu	37	1	23235526	23235526	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:23235526C>T	uc009vqj.1	+	13	2509	c.2364C>T	c.(2362-2364)ATC>ATT	p.I788I	EPHB2_uc001bge.2_Silent_p.I789I|EPHB2_uc001bgf.2_Silent_p.I788I|EPHB2_uc010odu.1_Silent_p.I730I	NM_017449	NP_059145	P29323	EPHB2_HUMAN	ephrin receptor EphB2 isoform 1 precursor	788	Cytoplasmic (Potential).|Protein kinase.			I -> F (in Ref. 5; AAA74244).	axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			ovary(3)|lung(1)|pancreas(1)	5		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GCGGAAAGATCCCCATCCGCT	0.458000									Hereditary_Prostate_Cancer				9	14					0	0	0.000274275	0	0
HPCA	3208	broad.mit.edu	37	1	33354742	33354742	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:33354742C>T	uc001bwh.2	+	2	283	c.243C>T	c.(241-243)GAC>GAT	p.D81D		NM_002143	NP_002134	P84074	HPCA_HUMAN	hippocalcin	81	EF-hand 2.|1 (Potential).						actin binding|calcium ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				GCACCATAGACTTTCGGGAGT	0.567000													29	46					0	0	0.000491102	0	0
CSMD2	114784	broad.mit.edu	37	1	34191090	34191090	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:34191090C>T	uc001bxn.1	-	17	2464	c.2435G>A	c.(2434-2436)CGG>CAG	p.R812Q	CSMD2_uc001bxm.1_Missense_Mutation_p.R852Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	812	CUB 5.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGAGTAAGTCCGCCCATCGCG	0.502000													16	23					0	0	0.00074312	0	0
MACF1	23499	broad.mit.edu	37	1	39788666	39788666	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:39788666C>T	uc010ois.1	+	34	4442	c.4237C>T	c.(4237-4239)CTG>TTG	p.L1413L	MACF1_uc001cda.1_Silent_p.L1321L|MACF1_uc001cdc.1_Silent_p.L500L|MACF1_uc009vvq.1_Silent_p.L470L|MACF1_uc001cdb.1_Silent_p.L500L	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1413					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACTCCGGCGTCTGGAGGAGGA	0.393000													27	53					0	0	0.000878237	0	0
AKR1A1	10327	broad.mit.edu	37	1	46034238	46034238	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:46034238C>T	uc001cod.2	+	7	1098	c.634C>T	c.(634-636)CCT>TCT	p.P212S	AKR1A1_uc001coe.2_Missense_Mutation_p.P212S|AKR1A1_uc001cof.2_Intron|AKR1A1_uc001cog.2_RNA	NM_006066	NP_006057	P14550	AK1A1_HUMAN	aldo-keto reductase family 1, member A1	212	NADP (By similarity).				glucose metabolic process		alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					TGCTTATAGCCCTTTGGGCTC	0.537000													12	18					0	0	0.00136819	0	0
LEPR	3953	broad.mit.edu	37	1	66064414	66064414	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:66064414G>A	uc001dci.2	+	8	1123	c.921G>A	c.(919-921)CAG>CAA	p.Q307Q	LEPR_uc001dcg.2_Silent_p.Q307Q|LEPR_uc001dch.2_Silent_p.Q307Q|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Silent_p.Q307Q|LEPR_uc001dck.2_Silent_p.Q307Q	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	307	Extracellular (Potential).|Fibronectin type-III 1.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATGAGGTTCAGGTGAGGGGCA	0.443000													15	34					0	0	0.000308642	0	0
LRRC7	57554	broad.mit.edu	37	1	70503805	70503805	+	Silent	SNP	A	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:70503805A>T	uc001dep.2	+	19	2214	c.2184A>T	c.(2182-2184)CCA>CCT	p.P728P	LRRC7_uc009wbg.2_Silent_p.P12P|LRRC7_uc001deq.2_5'UTR	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	728						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GGATTGCACCATCTTTCCCAC	0.512000													31	71					0	0	0.000409698	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342622	94342622	+	Missense_Mutation	SNP	T	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:94342622T>G	uc001dqf.2	-	2	907	c.869A>C	c.(868-870)AAA>ACA	p.K290T	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Missense_Mutation_p.K85T	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		TTTTGTTTCTTTAAGAGATTC	0.333000													11	28					0	0	0.000673444	0	0
CELSR2	1952	broad.mit.edu	37	1	109812152	109812152	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:109812152C>T	uc001dxa.3	+	21	6980	c.6919C>T	c.(6919-6921)CGC>TGC	p.R2307C		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2307	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GGTGCAGTTCCGCCTGCTGGA	0.612000													93	185					0	0	0.000781405	0	0
GPR61	83873	broad.mit.edu	37	1	110085718	110085718	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:110085718C>T	uc001dxy.2	+	2	757	c.74C>T	c.(73-75)CCC>CTC	p.P25L		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	25	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		ACCCCAGGTCCCTCTACTGCC	0.612000													14	16					0	0	0.000308642	0	0
AP4B1	10717	broad.mit.edu	37	1	114442652	114442652	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:114442652G>A	uc001eeb.2	-	5	1131	c.988C>T	c.(988-990)CTA>TTA	p.L330L	uc001edv.1_RNA|AP4B1_uc001eec.2_Silent_p.L162L|AP4B1_uc001eed.2_Silent_p.L330L|AP4B1_uc010owp.1_Silent_p.L231L|AP4B1_uc001eea.1_Silent_p.L124L|AP4B1_uc001eee.1_5'Flank|AP4B1_uc010owq.1_Silent_p.L237L	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	330					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTTTCTGTAGTTTGATGTAG	0.483000													83	144					0	0	0.000781405	0	0
SPAG17	200162	broad.mit.edu	37	1	118584660	118584660	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:118584660C>T	uc001ehk.2	-	21	2888	c.2820G>A	c.(2818-2820)TGG>TGA	p.W940*		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	940	Potential.					cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCTCTTCTTTCCATGCCTGTA	0.338000													36	56					0	0	0.000692331	0	0
BCL9	607	broad.mit.edu	37	1	147094242	147094242	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:147094242T>A	uc001epq.2	+	9	3813	c.3073T>A	c.(3073-3075)TAC>AAC	p.Y1025N	BCL9_uc010ozr.1_Missense_Mutation_p.Y951N	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1025	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CACCCCGTTATACCATGATGC	0.483000			T	IGH@|IGL@	B-ALL								27	64					0	0	0.000720815	0	0
FLG2	388698	broad.mit.edu	37	1	152327138	152327138	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:152327138C>T	uc001ezw.3	-	3	3197	c.3124G>A	c.(3124-3126)GGA>AGA	p.G1042R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1042	Filaggrin 3.|Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCTGATCCATGTTGTCCA	0.488000													61	126					0	0	0.000781405	0	0
KIFAP3	22920	broad.mit.edu	37	1	170003567	170003567	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:170003567C>G	uc001ggv.2	-	7	959	c.688G>C	c.(688-690)GAG>CAG	p.E230Q	KIFAP3_uc010ply.1_Missense_Mutation_p.E152Q|KIFAP3_uc001ggw.1_Missense_Mutation_p.E186Q	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	230					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTTTTAACTCATGATCAATA	0.308000													3	48					0	0	6.4e-05	0	0
DNM3	26052	broad.mit.edu	37	1	172100389	172100389	+	Silent	SNP	C	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:172100389C>G	uc001gie.2	+	14	1796	c.1620C>G	c.(1618-1620)GTC>GTG	p.V540V	DNM3_uc001gid.3_Silent_p.V540V|DNM3_uc009wwb.2_Silent_p.V540V|DNM3_uc001gif.2_Silent_p.V540V	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	550	PH.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						ACTGGTTCGTCCTTACTGCGG	0.423000													9	24					0	0	0.000673444	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204438517	204438517	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:204438517G>A	uc001haw.2	-	3	893	c.414C>T	c.(412-414)GTC>GTT	p.V138V	PIK3C2B_uc010pqv.1_Silent_p.V138V|PIK3C2B_uc001hax.1_Silent_p.V138V|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	138	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGGACGAAGAGACTCCCCCAT	0.577000													10	18					0	0	0.000442599	0	0
CR2	1380	broad.mit.edu	37	1	207640158	207640158	+	Missense_Mutation	SNP	T	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:207640158T>G	uc001hfw.2	+	2	440	c.346T>G	c.(346-348)TTT>GTT	p.F116V	CR2_uc001hfv.2_Missense_Mutation_p.F116V|CR2_uc009xch.2_Missense_Mutation_p.F116V	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	116	Sushi 2.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TTCTGTGACATTTGCCTGTAA	0.428000													8	28					0	0	0.000274275	0	0
USH2A	7399	broad.mit.edu	37	1	215848794	215848794	+	Silent	SNP	G	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:215848794G>T	uc001hku.1	-	63	12846	c.12459C>A	c.(12457-12459)GCC>GCA	p.A4153A		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4153	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGTCTGGAGGGGCTTCATCTG	0.557000										HNSCC(13;0.011)			12	27					3.07112e-06	2.40106e-05	0.000978159	1	0
DISC1	27185	broad.mit.edu	37	1	231830537	231830537	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:231830537C>T	uc001huz.2	+	2	1086	c.1033C>T	c.(1033-1035)CGG>TGG	p.R345W	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.R300W|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.R300W|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.R334W|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.R300W|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.R300W|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.R334W|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.R334W|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.R345W|DISC1_uc010pwp.1_Missense_Mutation_p.R345W|DISC1_uc010pwq.1_Missense_Mutation_p.R345W|DISC1_uc010pwr.1_Missense_Mutation_p.R345W|DISC1_uc010pws.1_Missense_Mutation_p.R345W|DISC1_uc010pwt.1_Missense_Mutation_p.R345W|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.R345W|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.R345W|DISC1_uc010pxb.1_Missense_Mutation_p.R345W|DISC1_uc010pxc.1_Missense_Mutation_p.R345W|DISC1_uc010pxd.1_Missense_Mutation_p.P13L|DISC1_uc010pxe.1_Missense_Mutation_p.R345W|DISC1_uc009xfr.2_Missense_Mutation_p.R300W|DISC1_uc010pxf.1_Missense_Mutation_p.R345W|DISC1_uc010pxg.1_Missense_Mutation_p.R345W|DISC1_uc010pxh.1_Missense_Mutation_p.R345W|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_Missense_Mutation_p.P13L|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.R345W|DISC1_uc010pxn.1_Missense_Mutation_p.P13L|DISC1_uc001hva.2_Missense_Mutation_p.R345W|DISC1_uc010pwm.1_Missense_Mutation_p.R345W|DISC1_uc001hux.1_Missense_Mutation_p.R345W|DISC1_uc001hvc.3_Missense_Mutation_p.R345W|DISC1_uc010pwn.1_Missense_Mutation_p.R345W	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	345	Interaction with TRAF3IP1.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GCTGAGAAACCGGAGGCAGAT	0.612000													5	13					0	0	0.000602214	0	0
RYR2	6262	broad.mit.edu	37	1	237868530	237868530	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:237868530G>A	uc001hyl.1	+	67	9587	c.9467G>A	c.(9466-9468)GGA>GAA	p.G3156E	RYR2_uc010pxz.1_Missense_Mutation_p.G111E	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3156	Helical; Name=M''; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCTGCATTAGGAGAATGTCTA	0.348000													4	23					0	0	0.000602214	0	0
NLRP3	114548	broad.mit.edu	37	1	247587438	247587438	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:247587438G>A	uc001icr.2	+	5	831	c.693G>A	c.(691-693)GGG>GGA	p.G231G	NLRP3_uc001ics.2_Silent_p.G231G|NLRP3_uc001icu.2_Silent_p.G231G|NLRP3_uc001icw.2_Silent_p.G231G|NLRP3_uc001icv.2_Silent_p.G231G|NLRP3_uc010pyw.1_Silent_p.G229G|NLRP3_uc001ict.1_Silent_p.G229G	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	231	ATP (Potential).|NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CAGGGATTGGGAAAACAATCC	0.542000													9	20					0	0	0.000274275	0	0
OR14A16	284532	broad.mit.edu	37	1	247978742	247978742	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:247978742G>A	uc001idm.1	-	1	290	c.290C>T	c.(289-291)TCC>TTC	p.S97F		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	97	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAGACCTGGGAAACACAGCC	0.453000													10	28					0	0	0.000673444	0	0
OR2M3	127062	broad.mit.edu	37	1	248366886	248366886	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:248366886G>A	uc010pzg.1	+	1	517	c.517G>A	c.(517-519)GAA>AAA	p.E173K		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGGTCTCGGGAAATAGCCCA	0.418000													51	88					0	0	0.000781405	0	0
ITIH2	3698	broad.mit.edu	37	10	7745421	7745421	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:7745421C>T	uc001ijs.2	+	1	186	c.24C>T	c.(22-24)TTC>TTT	p.F8F		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	8					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						CGTGCTTTTTCATCTGCTTCT	0.428000													15	59					0	0	0.000566183	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24874255	24874255	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:24874255G>A	uc001isb.2	-	26	5450	c.4963C>T	c.(4963-4965)CGA>TGA	p.R1655*	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1654	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						AGTTTTCCTCGGAAAAGCCTC	0.502000													4	37					0	0	0.000157383	0	0
MPP7	143098	broad.mit.edu	37	10	28420578	28420578	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:28420578C>T	uc001iua.1	-	8	762	c.358G>A	c.(358-360)GAC>AAC	p.D120N	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Missense_Mutation_p.D120N|MPP7_uc009xla.2_Missense_Mutation_p.D120N|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	120	L27 2.				establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						AACACTGGGTCGTAATTCTTC	0.338000													33	24					0	0	0.000953801	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37433940	37433940	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:37433940G>A	uc001iza.1	+	8	1342	c.1243G>A	c.(1243-1245)GAA>AAA	p.E415K		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	471						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						GTTCCCATCAGAATCCAAACA	0.254000													11	58					0	0	0.000219431	0	0
PCDH15	65217	broad.mit.edu	37	10	55591154	55591154	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:55591154C>T	uc001jju.1	-	30	4518	c.4123G>A	c.(4123-4125)GGG>AGG	p.G1375R	PCDH15_uc010qhq.1_Missense_Mutation_p.G1380R|PCDH15_uc010qhr.1_Missense_Mutation_p.G1375R|PCDH15_uc010qhs.1_Missense_Mutation_p.G1387R|PCDH15_uc010qht.1_Missense_Mutation_p.G1382R|PCDH15_uc010qhu.1_Missense_Mutation_p.G1375R|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.G1375R|PCDH15_uc010qhw.1_Missense_Mutation_p.G1338R|PCDH15_uc010qhx.1_Missense_Mutation_p.G1304R|PCDH15_uc010qhy.1_Missense_Mutation_p.G1380R|PCDH15_uc010qhz.1_Missense_Mutation_p.G1375R|PCDH15_uc010qia.1_Missense_Mutation_p.G1353R|PCDH15_uc010qib.1_Missense_Mutation_p.G1353R	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1375	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AACAAGGCCCCTTCTGTGTAT	0.493000										HNSCC(58;0.16)			8	42					0	0	0.000442599	0	0
PCDH15	65217	broad.mit.edu	37	10	55973787	55973787	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:55973787C>T	uc001jju.1	-	10	1402	c.1007G>A	c.(1006-1008)CGA>CAA	p.R336Q	PCDH15_uc010qhq.1_Missense_Mutation_p.R341Q|PCDH15_uc010qhr.1_Missense_Mutation_p.R336Q|PCDH15_uc010qhs.1_Missense_Mutation_p.R341Q|PCDH15_uc010qht.1_Missense_Mutation_p.R336Q|PCDH15_uc010qhu.1_Missense_Mutation_p.R336Q|PCDH15_uc001jjv.1_Missense_Mutation_p.R314Q|PCDH15_uc010qhv.1_Missense_Mutation_p.R336Q|PCDH15_uc010qhw.1_Missense_Mutation_p.R299Q|PCDH15_uc010qhx.1_Missense_Mutation_p.R336Q|PCDH15_uc010qhy.1_Missense_Mutation_p.R341Q|PCDH15_uc010qhz.1_Missense_Mutation_p.R336Q|PCDH15_uc010qia.1_Missense_Mutation_p.R314Q|PCDH15_uc010qib.1_Missense_Mutation_p.R314Q|PCDH15_uc001jjw.2_Missense_Mutation_p.R336Q	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	336	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATGGAAAAATCGTGGGTAATC	0.368000										HNSCC(58;0.16)			14	26					0	0	0.000219431	0	0
ECD	11319	broad.mit.edu	37	10	74916361	74916361	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:74916361G>A	uc001jtn.2	-	4	619	c.376C>T	c.(376-378)CCT>TCT	p.P126S	ECD_uc009xqx.2_Missense_Mutation_p.P126S|ECD_uc009xqy.2_Missense_Mutation_p.P126S|ECD_uc001jto.2_5'UTR	NM_007265	NP_009196	O95905	SGT1_HUMAN	suppressor of S. cerevisiae gcr2 isoform 1	126					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			pancreas(1)	1	Prostate(51;0.0119)					AGCCATTTAGGGAGAAAGTCA	0.338000													35	65					0	0	0.000509022	0	0
PAPSS2	9060	broad.mit.edu	37	10	89472847	89472847	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:89472847G>A	uc001kex.2	+	3	424	c.161G>A	c.(160-162)GGA>GAA	p.G54E	PAPSS2_uc001kew.2_Missense_Mutation_p.G54E|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	54	Adenylyl-sulfate kinase.|ATP (Potential).				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		TCTGGTGCTGGAAAAACAACG	0.428000													40	55					0	0	0.000781405	0	0
LIPA	3988	broad.mit.edu	37	10	90986655	90986655	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:90986655T>A	uc001kga.3	-	5	703	c.535A>T	c.(535-537)ATA>TTA	p.I179L	LIPA_uc001kgb.3_Missense_Mutation_p.I123L|LIPA_uc001kgc.3_Missense_Mutation_p.I181L|LIPA_uc010qnf.1_5'Flank|LIPA_uc009xtq.2_Missense_Mutation_p.I179L	NM_000235	NP_000226	P38571	LICH_HUMAN	lipase A precursor	179					lipid catabolic process	lysosome	lipase activity|sterol esterase activity				0		Colorectal(252;0.0162)		GBM - Glioblastoma multiforme(2;0.00406)		TACATACCTATAGTGGTGCCT	0.313000													18	22					0	0	0.000958276	0	0
IDE	3416	broad.mit.edu	37	10	94220977	94220977	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:94220977T>A	uc001kia.2	-	22	2870	c.2794A>T	c.(2794-2796)ACC>TCC	p.T932S	IDE_uc010qnp.1_Missense_Mutation_p.T377S|IDE_uc001khz.2_Missense_Mutation_p.T377S	NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	932					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTTCCTTGGTAAGTGTCTTT	0.254000													46	207					0	0	0.000781405	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602710	96602710	+	Missense_Mutation	SNP	G	A	A	rs144036596	byFrequency	TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:96602710G>A	uc010qnz.1	+	7	1078	c.1078G>A	c.(1078-1080)GAC>AAC	p.D360N	CYP2C19_uc010qny.1_Missense_Mutation_p.D338N	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	360					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GAGATACATCGACCTCATCCC	0.537000													24	32					0	0	0.000586117	0	0
CYP2C8	1558	broad.mit.edu	37	10	96798747	96798747	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:96798747C>T	uc001kkb.2	-	8	1293	c.1198G>A	c.(1198-1200)GAA>AAA	p.E400K	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.E330K|CYP2C8_uc010qob.1_Missense_Mutation_p.E314K|CYP2C8_uc010qoc.1_Missense_Mutation_p.E298K|CYP2C8_uc010qod.1_3'UTR	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	400					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TTAGGAAATTCTTTGTCATCA	0.383000													19	22					0	0	0.00121646	0	0
CCDC147	159686	broad.mit.edu	37	10	106152112	106152112	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:106152112C>T	uc001kyh.2	+	10	1621	c.1487C>T	c.(1486-1488)TCA>TTA	p.S496L		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	496	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		GCTGTGAGATCAGACAGAAAT	0.299000													20	30					0	0	0.000295444	0	0
ADAM12	8038	broad.mit.edu	37	10	127760116	127760116	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr10:127760116G>A	uc001ljk.2	-	12	1675	c.1262C>T	c.(1261-1263)TCT>TTT	p.S421F	ADAM12_uc010qul.1_Missense_Mutation_p.S372F|ADAM12_uc001ljm.2_Missense_Mutation_p.S421F|ADAM12_uc001ljn.2_Missense_Mutation_p.S418F|ADAM12_uc001ljl.3_Missense_Mutation_p.S418F	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	421	Extracellular (Potential).				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GCCCCCGAAAGACTCCCTGAC	0.532000													33	46					0	0	0.000491102	0	0
PKP3	11187	broad.mit.edu	37	11	397006	397006	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:397006G>A	uc001lpc.2	+	3	581	c.505G>A	c.(505-507)GGG>AGG	p.G169R		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	169					cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGAGCGCGGTGGGGTTGGGAG	0.721000													4	17					0	0	0.000602214	0	0
MUC2	4583	broad.mit.edu	37	11	1094763	1094764	+	Nonsense_Mutation	DNP	CC	TA	TA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:1094763_1094764CC>TA	uc001lsx.1	+	34	12964_12965	c.12937_12938CC>TA	c.(12937-12939)CCA>TAA	p.P4313*		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4313						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	AACGCCGACCCCACTCTCCACA	0.634000													39	50					0	0	6.4e-05	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606317	1606317	+	Missense_Mutation	SNP	G	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:1606317G>C	uc001ltu.1	-	1	197	c.163C>G	c.(163-165)CGT>GGT	p.R55G	LOC338651_uc009ycx.1_Intron|LOC338651_uc001ltt.1_Intron	NM_001005922	NP_001005922	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	55	8 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GTTGGCACACGGCAGCACACG	0.682000													3	86					0	0	0.00024832	0	0
OR51I1	390063	broad.mit.edu	37	11	5462628	5462628	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:5462628G>A	uc010qze.1	-	1	117	c.117C>T	c.(115-117)ATC>ATT	p.I39I	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001005288	NP_001005288	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTACAATGGAGATCATGTAGA	0.522000													10	37					0	0	0.000673444	0	0
DENND5A	23258	broad.mit.edu	37	11	9225804	9225804	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:9225804G>A	uc001mhl.2	-	4	607	c.352C>T	c.(352-354)CAT>TAT	p.H118Y	DENND5A_uc010rbw.1_Missense_Mutation_p.H118Y|DENND5A_uc010rbx.1_RNA	NM_015213	NP_056028	Q6IQ26	DEN5A_HUMAN	RAB6 interacting protein 1	118	UDENN.									liver(1)	1						ATAAAGGCATGGAATTGGGGC	0.493000													11	29					0	0	0.000978159	0	0
E2F8	79733	broad.mit.edu	37	11	19247016	19247016	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:19247016G>A	uc001mpm.2	-	12	2695	c.2173C>T	c.(2173-2175)CCC>TCC	p.P725S	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.P725S	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	725					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TTCTGGATGGGAACAGGGTGG	0.552000													10	35					0	0	0.000673444	0	0
OR4X2	119764	broad.mit.edu	37	11	48267238	48267238	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:48267238G>A	uc001ngs.1	+	1	583	c.583G>A	c.(583-585)GGA>AGA	p.G195R		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	195	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGTTGCCAATGGAGGCACCCT	0.498000													42	75					0	0	0.000437636	0	0
SERPING1	710	broad.mit.edu	37	11	57369545	57369545	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:57369545C>G	uc001nkp.1	+	4	779	c.588C>G	c.(586-588)ATC>ATG	p.I196M	SERPING1_uc001nkq.1_Missense_Mutation_p.I196M|SERPING1_uc010rju.1_Missense_Mutation_p.I144M|SERPING1_uc010rjv.1_Missense_Mutation_p.I201M|SERPING1_uc001nkr.1_Missense_Mutation_p.I196M|SERPING1_uc009ymi.1_Missense_Mutation_p.I196M|SERPING1_uc009ymj.1_Missense_Mutation_p.I196M|SERPING1_uc001nks.1_Translation_Start_Site	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	196					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						TGGAGAGCATCCTCTCTTACC	0.552000									Hereditary_Angioedema				7	18					0	0	0.000157383	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995730	57995730	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:57995730G>A	uc010rkd.1	-	1	618	c.618C>T	c.(616-618)GTC>GTT	p.V206V		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				GGATGCTCACGACATAGAGGA	0.627000													6	25					0	0	0.00116845	0	0
DAK	26007	broad.mit.edu	37	11	61113373	61113373	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:61113373G>A	uc001nre.2	+	17	1787	c.1530G>A	c.(1528-1530)AAG>AAA	p.K510K	DAK_uc009ynm.1_Silent_p.K440K	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	510	DhaL.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						AAGCCTGGAAGAGCCCAGGAG	0.537000													17	27					0	0	0.000958276	0	0
AHNAK	79026	broad.mit.edu	37	11	62284753	62284753	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:62284753G>A	uc001ntl.2	-	5	17436	c.17136C>T	c.(17134-17136)ATC>ATT	p.I5712I	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5712	Nuclear localization signal (Potential).				nervous system development	nucleus	protein binding	p.I5712T(1)		ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGGGCATTTTGATCTTGGACT	0.473000													32	51					0	0	0.000692331	0	0
AHNAK	79026	broad.mit.edu	37	11	62291166	62291166	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:62291166G>A	uc001ntl.2	-	5	11023	c.10723C>T	c.(10723-10725)CCA>TCA	p.P3575S	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3575					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAACCTCTGGCCCTTTCAGA	0.468000													56	101					0	0	0.000781405	0	0
AHNAK	79026	broad.mit.edu	37	11	62294090	62294090	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:62294090G>A	uc001ntl.2	-	5	8099	c.7799C>T	c.(7798-7800)TCT>TTT	p.S2600F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2600					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTTGGGCAGAGAAACATCCAC	0.507000													36	92					0	0	0.00111076	0	0
INTS5	80789	broad.mit.edu	37	11	62416686	62416686	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:62416686G>A	uc001nud.2	-	2	919	c.866C>T	c.(865-867)CCC>CTC	p.P289L	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	289					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						GGCAATCTTGGGCACCCGTTT	0.597000													13	15					0	0	0.000219431	0	0
CABP4	57010	broad.mit.edu	37	11	67223182	67223182	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:67223182C>T	uc001olo.2	+	1	365	c.288C>T	c.(286-288)TCC>TCT	p.S96S	GPR152_uc001olm.2_5'Flank|CABP4_uc001oln.2_5'UTR	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	96					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CTCGCCAGTCCCACCGACATC	0.682000													3	11					0	0	0.00024832	0	0
ANKRD42	338699	broad.mit.edu	37	11	82922398	82922398	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:82922398G>A	uc001ozz.1	+	5	850	c.428G>A	c.(427-429)CGG>CAG	p.R143Q	ANKRD42_uc009yvi.1_Missense_Mutation_p.R171Q|ANKRD42_uc010rsv.1_Missense_Mutation_p.R171Q|ANKRD42_uc001paa.2_Missense_Mutation_p.R171Q|ANKRD42_uc001pab.1_Missense_Mutation_p.R170Q	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	143	ANK 4.									skin(1)	1						TTTCATGGGCGGCTTGGCTGC	0.408000													30	40					0	0	0.00178596	0	0
FAT3	120114	broad.mit.edu	37	11	92087287	92087287	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:92087287C>T	uc001pdj.3	+	1	2026	c.2009C>T	c.(2008-2010)TCA>TTA	p.S670L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	670	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTAACATTTCAGTCCTACAT	0.403000										TCGA Ovarian(4;0.039)			134	263					0	0	0.000781405	0	0
CNTN5	53942	broad.mit.edu	37	11	99941237	99941237	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:99941237G>A	uc001pga.2	+	11	1583	c.1244G>A	c.(1243-1245)GGA>GAA	p.G415E	CNTN5_uc009ywv.1_Missense_Mutation_p.G415E|CNTN5_uc001pfz.2_Missense_Mutation_p.G415E|CNTN5_uc001pgb.2_Missense_Mutation_p.G341E	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	415	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AAGGCTACTGGAAAACCCAGA	0.473000													8	14					0	0	0.000274275	0	0
DRD2	1813	broad.mit.edu	37	11	113283545	113283545	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:113283545C>T	uc001pnz.2	-	6	1192	c.871G>A	c.(871-873)GAG>AAG	p.E291K	DRD2_uc010rwv.1_Missense_Mutation_p.E290K|DRD2_uc001poa.3_Missense_Mutation_p.E291K|DRD2_uc001pob.3_Missense_Mutation_p.E262K	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	291	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CGGGTCCTCTCGGGTGGGCTG	0.677000													9	38					0	0	0.000673444	0	0
VPS11	55823	broad.mit.edu	37	11	118951915	118951916	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:118951915_118951916CG>AT	uc010ryx.1	+	16	2594_2595	c.2552_2553CG>AT	c.(2551-2553)TCG>TAT	p.S851Y	VPS11_uc010ryy.1_Missense_Mutation_p.S697Y	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	851	RING-type.				protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GAGAGTTACTCGGAAAGTGATG	0.525000													5	137					0	0	6.4e-05	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123476185	123476185	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:123476185C>T	uc001pyx.2	+	9	1222	c.893C>T	c.(892-894)TCG>TTG	p.S298L	GRAMD1B_uc001pyw.2_Missense_Mutation_p.S305L|GRAMD1B_uc010rzw.1_Missense_Mutation_p.S258L|GRAMD1B_uc010rzx.1_Missense_Mutation_p.S258L|GRAMD1B_uc009zbe.1_Missense_Mutation_p.S294L|GRAMD1B_uc001pyy.2_5'Flank	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	298						integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		GCCCCCGTCTCGGTATGGGCA	0.562000													13	48					0	0	0.000422831	0	0
OR8B4	283162	broad.mit.edu	37	11	124294282	124294282	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr11:124294282C>G	uc010sak.1	-	1	486	c.486G>C	c.(484-486)ATG>ATC	p.M162I		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TCAGTCGCAGCATGCTTCCAG	0.542000													5	3					0	0	8.12818e-05	0	0
PTPN6	5777	broad.mit.edu	37	12	7063977	7063977	+	Silent	SNP	T	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:7063977T>C	uc001qsb.2	+	4	578	c.336T>C	c.(334-336)CAT>CAC	p.H112H	PTPN6_uc001qsa.1_Silent_p.H114H|PTPN6_uc010sfr.1_Silent_p.H73H|PTPN6_uc009zfl.1_Silent_p.H112H|PTPN6_uc010sfs.1_Silent_p.H100H	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	112	SH2 2.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						GGTGGTACCATGGCCACATGT	0.607000													12	19					0	0	0.00185496	0	0
ACSM4	341392	broad.mit.edu	37	12	7479638	7479638	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:7479638G>A	uc001qsx.1	+	12	1603	c.1603G>A	c.(1603-1605)GAA>AAA	p.E535K		NM_001080454	NP_001073923	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	535					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding				0						ATTAACTCTTGAACTTCAGGA	0.378000													7	13					0	0	0.000157383	0	0
CSDA	8531	broad.mit.edu	37	12	10865878	10865878	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:10865878G>A	uc001qyt.2	-	5	748	c.505C>T	c.(505-507)CGT>TGT	p.R169C	CSDA_uc001qyu.2_Missense_Mutation_p.R169C	NM_003651	NP_003642	P16989	DBPA_HUMAN	cold shock domain protein A isoform a	169					negative regulation of transcription from RNA polymerase II promoter|response to cold	cytoplasm|nucleus	double-stranded DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|lung(1)|large_intestine(1)	4	Glioma(1;0.155)					GCAGCGTAACGACTCCCTTCC	0.502000													17	64					0	0	0.000422831	0	0
LRP6	4040	broad.mit.edu	37	12	12356312	12356313	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:12356312_12356313CC>AA	uc001rah.3	-	3	613_614	c.471_472GG>TT	c.(469-474)TGGGGA>TGTTGA	p.157_158WG>C*	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Nonsense_Mutation_p.157_158WG>C*	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	157_158	Extracellular (Potential).|LDL-receptor class B 3.|Beta-propeller 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GGCACTTCTCCCCAGTCTGTCC	0.342000													11	413					0	0	6.4e-05	0	0
MLL2	8085	broad.mit.edu	37	12	49445809	49445809	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:49445809G>A	uc001rta.3	-	10	1657	c.1657C>T	c.(1657-1659)CCT>TCT	p.P553S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	553	15 X 5 AA repeats of S/P-P-P-E/P-E/A.|Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGGGACAAAGGAGATTCTTCA	0.597000			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			26	46					0	0	0.001512	0	0
SUOX	6821	broad.mit.edu	37	12	56397658	56397658	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:56397658C>T	uc001six.2	+	6	811	c.485C>T	c.(484-486)CCT>CTT	p.P162L	SUOX_uc001siy.2_Missense_Mutation_p.P162L|SUOX_uc001siz.2_Missense_Mutation_p.P162L|SUOX_uc001sja.2_Missense_Mutation_p.P162L	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	162						mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GAGCTGAATCCTGAAGACAAG	0.567000													16	28					0	0	0.000958276	0	0
R3HDM2	22864	broad.mit.edu	37	12	57660609	57660609	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:57660609G>A	uc009zpm.1	-	17	2029	c.1994C>T	c.(1993-1995)TCT>TTT	p.S665F	R3HDM2_uc010srn.1_RNA|R3HDM2_uc001snu.2_Missense_Mutation_p.S360F|R3HDM2_uc001snr.2_Missense_Mutation_p.S392F|R3HDM2_uc001sns.2_Missense_Mutation_p.S665F|R3HDM2_uc001snt.2_Missense_Mutation_p.S679F|R3HDM2_uc009zpn.1_Intron	NM_014925	NP_055740	Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	665	Gln-rich.					nucleus	nucleic acid binding			ovary(2)	2						AAACCCTACAGAAGGGCTGGG	0.567000													6	7					0	0	8.12818e-05	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85518179	85518179	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:85518179C>T	uc001tac.2	+	17	4000	c.3889C>T	c.(3889-3891)CAG>TAG	p.Q1297*	LRRIQ1_uc001tab.1_Nonsense_Mutation_p.Q1297*	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1297										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATTAGTATGTCAGAAGAGAGA	0.408000													51	115					0	0	0.000781405	0	0
C12orf63	374467	broad.mit.edu	37	12	97043713	97043713	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:97043713G>A	uc001tet.1	+	2	88	c.10G>A	c.(10-12)GAA>AAA	p.E4K		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	4										skin(6)|ovary(1)	7						AATGAGTGATGAAAATATGTC	0.318000													16	31					0	0	0.00121646	0	0
CCDC63	160762	broad.mit.edu	37	12	111311717	111311717	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:111311717C>T	uc001trv.1	+	5	636	c.441C>T	c.(439-441)CCC>CCT	p.P147P	CCDC63_uc009zvt.1_Silent_p.P62P|CCDC63_uc010sye.1_Silent_p.P107P|CCDC63_uc001trw.1_Silent_p.P62P	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	147	Potential.									skin(6)|ovary(1)|pancreas(1)	8						CCAATAACCCCCGGAAACTGC	0.418000													48	76					0	0	0.000781405	0	0
NAA25	80018	broad.mit.edu	37	12	112481497	112481497	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:112481497G>A	uc001ttm.2	-	18	2202	c.2182C>T	c.(2182-2184)CGT>TGT	p.R728C	NAA25_uc001ttn.3_RNA|NAA25_uc009zvz.1_Missense_Mutation_p.R700C|NAA25_uc009zwa.1_Missense_Mutation_p.R728C	NM_024953	NP_079229	Q14CX7	NAA25_HUMAN	mitochondrial distribution and morphology 20	728						cytoplasm	protein binding			ovary(1)|breast(1)|pancreas(1)	3						AGGAGCAAACGAAGAATATCA	0.468000													14	61					0	0	0.000219431	0	0
OAS3	4940	broad.mit.edu	37	12	113386841	113386841	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:113386841C>T	uc001tug.2	+	6	1292	c.1205C>T	c.(1204-1206)CCG>CTG	p.P402L		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	402	Linker.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						CCCTCTGTGCCGGGAATGGCC	0.622000													4	18					0	0	0.00116845	0	0
TAOK3	51347	broad.mit.edu	37	12	118650786	118650786	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:118650786C>T	uc001twx.2	-	11	1047	c.752G>A	c.(751-753)AGG>AAG	p.R251K	TAOK3_uc001tww.2_Missense_Mutation_p.R81K|TAOK3_uc001twy.3_Missense_Mutation_p.R251K	NM_016281	NP_057365	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	251	Protein kinase.				MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AACAAATCTCCTAAAGGAGTC	0.363000													10	22					0	0	0.000673444	0	0
GCN1L1	10985	broad.mit.edu	37	12	120595818	120595818	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr12:120595818G>A	uc001txo.2	-	26	2935	c.2922C>T	c.(2920-2922)TCC>TCT	p.S974S		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	974					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGCTGGCGCGGACAAGGGCG	0.582000													16	32					0	0	0.000422831	0	0
IPO5	3843	broad.mit.edu	37	13	98658579	98658579	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr13:98658579G>A	uc001vnf.1	+	14	1758	c.1693G>A	c.(1693-1695)GGT>AGT	p.G565S	IPO5_uc001vne.2_Missense_Mutation_p.G583S|IPO5_uc010tik.1_Missense_Mutation_p.G440S|IPO5_uc010til.1_Missense_Mutation_p.G505S|IPO5_uc001vng.1_Missense_Mutation_p.G186S	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	565					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						TAGCCTCATTGGTCTGGCTGT	0.254000													5	7					0	0	0.000602214	0	0
GRTP1	79774	broad.mit.edu	37	13	113999219	113999219	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr13:113999219G>T	uc001vtn.2	-	5	618	c.521C>A	c.(520-522)TCT>TAT	p.S174Y	GRTP1_uc010tkb.1_Missense_Mutation_p.S96Y|GRTP1_uc010tkc.1_Missense_Mutation_p.S174Y	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	174	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CAGCCAAAAAGATTCTTCTTC	0.353000													24	21					7.01153e-11	5.56608e-10	0.00127121	1	0
CHD8	57680	broad.mit.edu	37	14	21861911	21861911	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:21861911G>A	uc001was.1	-	32	5300	c.5206C>T	c.(5206-5208)CAG>TAG	p.Q1736*	CHD8_uc001war.1_Nonsense_Mutation_p.Q1632*|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2015					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CTGGGGACCTGGGTAGCTGTC	0.582000													7	6					0	0	0.000157383	0	0
MMP14	4323	broad.mit.edu	37	14	23311622	23311622	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:23311622C>T	uc001whc.2	+	4	618	c.384C>T	c.(382-384)ATC>ATT	p.I128I		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	128	Extracellular (Potential).					extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		ACCTCAGCATCCAGAATTACA	0.612000													6	5					0	0	0.00116845	0	0
MYH7	4625	broad.mit.edu	37	14	23893208	23893208	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:23893208C>T	uc001wjx.2	-	23	2936	c.2830G>A	c.(2830-2832)GAA>AAA	p.E944K		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	944	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CACTCATCTTCCAGCTTGCGC	0.517000													22	45					0	0	0.000295444	0	0
RPL36AL	6166	broad.mit.edu	37	14	50085802	50085802	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:50085802G>A	uc001wwq.1	-	2	127	c.21C>T	c.(19-21)ACC>ACT	p.T7T	SDCCAG1_uc010anj.1_Intron|MGAT2_uc001wwr.2_5'Flank	NM_001001	NP_000992	Q969Q0	RL36L_HUMAN	ribosomal protein L36a-like protein	7					translation	ribosome	structural constituent of ribosome				0	all_epithelial(31;0.0021)|Breast(41;0.0124)					AGGTTCTTCGGGTTTTAGGTA	0.413000													10	53					0	0	0.000673444	0	0
ERO1L	30001	broad.mit.edu	37	14	53150624	53150624	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:53150624A>G	uc001wzv.2	-	2	342	c.116T>C	c.(115-117)GTT>GCT	p.V39A	ERO1L_uc001wzw.2_RNA|ERO1L_uc010aof.2_RNA	NM_014584	NP_055399	Q96HE7	ERO1A_HUMAN	ERO1-like precursor	39					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor				0	Breast(41;0.226)					GTAACCACTAACCTGTTACAA	0.358000													6	39					0	0	0.00116845	0	0
PRKCH	5583	broad.mit.edu	37	14	61789030	61789030	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:61789030G>A	uc001xfn.2	+	1	516	c.211G>A	c.(211-213)GAG>AAG	p.E71K	PRKCH_uc010tsa.1_Intron|uc001xfm.2_Intron	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	71	C2.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		GTACAACGAGGAGTTTTGCGC	0.632000													10	13					0	0	0.00136819	0	0
SPTB	6710	broad.mit.edu	37	14	65252634	65252635	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:65252634_65252635GG>AA	uc001xht.2	-	16	3650_3651	c.3596_3597CC>TT	c.(3595-3597)TCC>TTT	p.S1199F	SPTB_uc001xhr.2_Missense_Mutation_p.S1199F|SPTB_uc001xhs.2_Missense_Mutation_p.S1199F|SPTB_uc001xhu.2_Missense_Mutation_p.S1199F	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1199	Spectrin 9.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton	p.S1199C(1)		ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CAGCTTCCAGGGAGTCTGGGGG	0.530000													10	62					0	0	6.4e-05	0	0
KIAA1737	85457	broad.mit.edu	37	14	77579932	77579932	+	Silent	SNP	G	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:77579932G>T	uc001xtd.2	+	4	650	c.471G>T	c.(469-471)CTG>CTT	p.L157L	KIAA1737_uc001xtc.1_Silent_p.L59L	NM_033426	NP_219494	Q9C0C6	K1737_HUMAN	KIAA1737 protein	157											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		TGCCCATTCTGAATTCTTACA	0.478000													16	27					2.94398e-08	2.31569e-07	0.000958276	1	0
MIR342	442909	broad.mit.edu	37	14	100576066	100576066	+	RNA	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:100576066C>T	hsa-mir-342|MI0000805	+			c.75C>T			EVL_uc001ygt.2_Intron|EVL_uc001ygv.2_Intron|EVL_uc001ygu.2_Intron|EVL_uc010avu.2_Intron																	0						acacagaaatcgcacccgtca	0.294000													11	3					0	0	0.00185496	0	0
BRF1	2972	broad.mit.edu	37	14	105693012	105693013	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr14:105693012_105693013GG>AA	uc001yqp.2	-	8	1236_1237	c.873_874CC>TT	c.(871-876)CCCCCC>CCTTCC	p.P292S	BRF1_uc010tyo.1_Missense_Mutation_p.P177S|BRF1_uc010typ.1_Missense_Mutation_p.P177S|BRF1_uc001yql.2_Missense_Mutation_p.P88S|BRF1_uc001yqo.2_Missense_Mutation_p.P54S|BRF1_uc010axg.1_Missense_Mutation_p.P265S|BRF1_uc001yqn.2_RNA|BRF1_uc010axh.1_RNA|BRF1_uc010axj.1_RNA	NM_001519	NP_001510	Q92994	TF3B_HUMAN	transcription initiation factor IIIB isoform 1	292					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		GTGTACGAGGGGGGGTCGCACT	0.579000													10	23					0	0	6.4e-05	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22866942	22866942	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:22866942T>A	uc001yur.3	+	18	2589	c.2459T>A	c.(2458-2460)ATT>AAT	p.I820N	TUBGCP5_uc001yuq.2_Missense_Mutation_p.I820N	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	820					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		TGTCAAAAAATTTATAATCAA	0.303000													10	82					0	0	0.000673444	0	0
HERC2	8924	broad.mit.edu	37	15	28386959	28386959	+	Missense_Mutation	SNP	T	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:28386959T>G	uc001zbj.2	-	77	11840	c.11734A>C	c.(11734-11736)AGC>CGC	p.S3912R		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3912					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATGTTTTCGCTGTCTGCCATT	0.328000													45	248					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	15	28900554	28900554	+	RNA	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:28900554C>T	uc010uan.1	+	3		c.485C>T			uc010azc.2_RNA|uc010uao.1_RNA					Homo sapiens cDNA FLJ55955 complete cds, highly similar to HECT domain and RCC1-like domain-containing protein 2.																		CTCTGACGTGCCGTTACTCAG	0.572000													6	25					0	0	0.00116845	0	0
RYR3	6263	broad.mit.edu	37	15	34153323	34153323	+	Silent	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:34153323A>G	uc001zhi.2	+	102	14479	c.14409A>G	c.(14407-14409)ACA>ACG	p.T4803T	RYR3_uc010bar.2_Silent_p.T4798T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4803					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACTTTGACACAACCCCTCATG	0.383000													13	10					0	0	0.000219431	0	0
INO80	54617	broad.mit.edu	37	15	41371979	41371979	+	Nonsense_Mutation	SNP	C	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:41371979C>A	uc001zni.2	-	9	1264	c.1051G>T	c.(1051-1053)GAG>TAG	p.E351*	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	351	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.|DBINO.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TCTACTTTCTCATATTTCTTC	0.532000													11	454					0.000673444	0.00521767	0.000673444	1	0
CYP19A1	1588	broad.mit.edu	37	15	51519994	51519994	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:51519994G>A	uc001zyz.3	-	5	684	c.433C>T	c.(433-435)CGA>TGA	p.R145*	CYP19A1_uc001zza.3_Nonsense_Mutation_p.R145*|CYP19A1_uc001zzb.2_Nonsense_Mutation_p.R145*|CYP19A1_uc001zzd.2_Nonsense_Mutation_p.R145*|CYP19A1_uc010bey.1_Nonsense_Mutation_p.R145*	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	145					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	AAGAAGGGTCGAGTTGTTTTC	0.363000													68	34					0	0	0.000781405	0	0
MEGF11	84465	broad.mit.edu	37	15	66263027	66263027	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:66263027C>T	uc002apm.2	-	8	904	c.763G>A	c.(763-765)GGA>AGA	p.G255R	MEGF11_uc002apl.2_Missense_Mutation_p.G180R|MEGF11_uc002apn.1_Missense_Mutation_p.G255R	NM_032445	NP_115821	A6BM72	MEG11_HUMAN	multiple EGF-like-domains 11 precursor	255	EGF-like 4.					basolateral plasma membrane|integral to membrane				pancreas(1)	1						CACACTGCTCCCTAAAAGAAA	0.582000													14	7					0	0	0.000566183	0	0
MAP2K1	5604	broad.mit.edu	37	15	66727455	66727455	+	Missense_Mutation	SNP	G	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:66727455G>T	uc010bhq.2	+	2	646	c.171G>T	c.(169-171)AAG>AAT	p.K57N	MAP2K1_uc010ujp.1_Missense_Mutation_p.K35N	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	57					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TTACCCAGAAGCAGAAGGTGG	0.542000									Cardiofaciocutaneous_syndrome				129	81					2.27795e-59	1.81954e-58	0.000781405	1	0
SCAMP5	192683	broad.mit.edu	37	15	75310803	75310803	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:75310803C>T	uc002azk.1	+	6	602	c.440C>T	c.(439-441)TCG>TTG	p.S147L	SCAMP5_uc002azl.1_Missense_Mutation_p.S147L|SCAMP5_uc002azm.1_Missense_Mutation_p.S147L|SCAMP5_uc002azn.1_Missense_Mutation_p.S155L|SCAMP5_uc010uly.1_Missense_Mutation_p.S76L	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	147	Extracellular (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						AACATTGGCTCGGCGGTGGTG	0.582000													51	219					0	0	0.000781405	0	0
CHRNA3	1136	broad.mit.edu	37	15	78889060	78889060	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:78889060C>T	uc002bec.2	-	6	1590	c.1404G>A	c.(1402-1404)TGG>TGA	p.W468*	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_Intron|CHRNA3_uc010blg.1_RNA	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	468	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						CAACATACTTCCAATCATCTT	0.388000													63	28					0	0	0.000781405	0	0
TMC3	342125	broad.mit.edu	37	15	81625167	81625167	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:81625167G>A	uc002bgo.1	-	22	2896	c.2896C>T	c.(2896-2898)CTC>TTC	p.L966F	TMC3_uc010blr.1_RNA	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	966	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						GCCCGACGGAGGTCTATCAGG	0.587000													4	22					0	0	0.000602214	0	0
AKAP13	11214	broad.mit.edu	37	15	86283477	86283477	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:86283477C>T	uc002blv.1	+	34	7752	c.7582C>T	c.(7582-7584)CTC>TTC	p.L2528F	AKAP13_uc002blu.1_Missense_Mutation_p.L2532F|AKAP13_uc002blw.1_Missense_Mutation_p.L993F|AKAP13_uc002blx.1_Missense_Mutation_p.L773F	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	2528	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CGTTGTTCATCTCTACGAGCT	0.473000													72	30					0	0	0.000781405	0	0
AGBL1	123624	broad.mit.edu	37	15	87089299	87089299	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:87089299G>A	uc002blz.1	+	19	2694	c.2614G>A	c.(2614-2616)GAA>AAA	p.E872K		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	872					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TAGCATCAAGGAAACCTTGTG	0.468000													11	62					0	0	0.00136819	0	0
C15orf42	90381	broad.mit.edu	37	15	90138635	90138635	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:90138635C>T	uc002boe.2	+	7	1693	c.1693C>T	c.(1693-1695)CGT>TGT	p.R565C		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	565					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			AGGGGTCCCTCGTACTCCAGT	0.438000													10	80					0	0	0.00136819	0	0
MAN2A2	4122	broad.mit.edu	37	15	91453440	91453441	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:91453440_91453441CG>AT	uc010bnz.2	+	10	1610_1611	c.1495_1496CG>AT	c.(1495-1497)CGG>ATG	p.R499M	MAN2A2_uc010boa.2_Missense_Mutation_p.R541M|MAN2A2_uc002bqc.2_Missense_Mutation_p.R499M|MAN2A2_uc010uql.1_Intron|MAN2A2_uc010uqm.1_Intron|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	499	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CTATGCGGACCGGGAGGATCAT	0.589000													8	609					0	0	6.4e-05	0	0
MAN2A2	4122	broad.mit.edu	37	15	91454684	91454685	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:91454684_91454685CC>AA	uc010bnz.2	+	14	2128_2129	c.2013_2014CC>AA	c.(2011-2016)CCCCGC>CCAAGC	p.R672S	MAN2A2_uc002bqc.2_Missense_Mutation_p.R672S|MAN2A2_uc010uql.1_Missense_Mutation_p.R334S|MAN2A2_uc010uqm.1_Missense_Mutation_p.R251S|MAN2A2_uc010uqn.1_5'Flank	NM_006122	NP_006113	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	672	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			large_intestine(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			TCAACTCTCCCCGCGTGCGTGT	0.624000													13	655					0	0	6.4e-05	0	0
UNC45A	55898	broad.mit.edu	37	15	91486150	91486151	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:91486150_91486151CG>AT	uc002bqg.2	+	8	1205_1206	c.865_866CG>AT	c.(865-867)CGG>ATG	p.R289M	UNC45A_uc002bqd.2_Missense_Mutation_p.R274M	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	289					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGATCCTGCCCGGGAGCTGAAG	0.559000													11	458					0	0	6.4e-05	0	0
TMC5	79838	broad.mit.edu	37	16	19485576	19485576	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr16:19485576G>A	uc002dgc.3	+	12	2817	c.2068G>A	c.(2068-2070)GAA>AAA	p.E690K	TMC5_uc010vaq.1_Missense_Mutation_p.E638K|TMC5_uc002dgb.3_Missense_Mutation_p.E690K|TMC5_uc010var.1_Missense_Mutation_p.E690K|TMC5_uc002dgd.1_Missense_Mutation_p.E444K|TMC5_uc002dge.3_Missense_Mutation_p.E444K|TMC5_uc002dgf.3_Missense_Mutation_p.E373K|TMC5_uc002dgg.3_Missense_Mutation_p.E331K	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	690	Cytoplasmic (Potential).					integral to membrane				skin(1)	1						GCCACGGCACGAAGTCTACGT	0.527000													24	47					0	0	0.000375601	0	0
DNAH3	55567	broad.mit.edu	37	16	20946803	20946803	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr16:20946803C>T	uc010vbe.1	-	61	11864	c.11864G>A	c.(11863-11865)TGG>TAG	p.W3955*	DNAH3_uc010vbd.1_Nonsense_Mutation_p.W1390*	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3955					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTTGTCAATCCATTCCTGGAG	0.378000													6	20					0	0	0.00116845	0	0
TNRC6A	27327	broad.mit.edu	37	16	24817563	24817563	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr16:24817563A>G	uc002dmm.2	+	16	4402	c.4288A>G	c.(4288-4290)AGA>GGA	p.R1430G	TNRC6A_uc010bxs.2_Missense_Mutation_p.R1177G|TNRC6A_uc002dmn.2_Missense_Mutation_p.R1128G|TNRC6A_uc002dmo.2_Missense_Mutation_p.R1069G|TNRC6A_uc002dmp.2_Missense_Mutation_p.R31G|TNRC6A_uc002dmq.2_Missense_Mutation_p.R97G	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1430					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GCAGAGTCAGAGAAGCGTGCC	0.502000													11	28					0	0	0.00136819	0	0
SH2B1	25970	broad.mit.edu	37	16	28878039	28878039	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr16:28878039C>T	uc002dri.2	+	4	1063	c.624C>T	c.(622-624)ACC>ACT	p.T208T	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Silent_p.T208T|SH2B1_uc002drk.2_Silent_p.T208T|SH2B1_uc002drl.2_Silent_p.T208T|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Silent_p.T208T|SH2B1_uc002drm.2_Silent_p.T208T	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	208	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Required for NGF signaling (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GGGCTGGGACCGTTGGTAGGG	0.637000													9	16					0	0	0.000274275	0	0
ITGAD	3681	broad.mit.edu	37	16	31425822	31425822	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr16:31425822C>T	uc002ebv.1	+	17	2096	c.2047C>T	c.(2047-2049)CTG>TTG	p.L683L	ITGAD_uc010cap.1_Silent_p.L684L	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	683	Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						CCCAGGTCGTCTGACTTCTCG	0.473000													69	142					0	0	0.000781405	0	0
CDH8	1006	broad.mit.edu	37	16	61858917	61858917	+	Silent	SNP	C	T	T	rs148693252	byFrequency	TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr16:61858917C>T	uc002eog.1	-	5	1086	c.834G>A	c.(832-834)CAG>CAA	p.Q278Q	CDH8_uc002eoh.2_Silent_p.Q47Q	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	278	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TTAACTTACTCTGTGCAAATT	0.353000													8	16					0	0	0.000673444	0	0
NLRP1	22861	broad.mit.edu	37	17	5461774	5461774	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:5461774C>T	uc002gci.2	-	4	2797	c.2242G>A	c.(2242-2244)GAC>AAC	p.D748N	NLRP1_uc002gcg.1_Missense_Mutation_p.D748N|NLRP1_uc002gck.2_Missense_Mutation_p.D748N|NLRP1_uc002gcj.2_Missense_Mutation_p.D748N|NLRP1_uc002gcl.2_Missense_Mutation_p.D748N|NLRP1_uc002gch.3_Missense_Mutation_p.D748N|NLRP1_uc010clh.2_Missense_Mutation_p.D748N	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	748					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				AGCTCCATGTCTGTTTCTACA	0.502000													25	55					0	0	0.00178596	0	0
C17orf81	23587	broad.mit.edu	37	17	7156241	7156241	+	Nonsense_Mutation	SNP	G	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:7156241G>T	uc002gfg.1	+	4	267	c.160G>T	c.(160-162)GAG>TAG	p.E54*	DULLARD_uc002gfd.2_5'Flank|DULLARD_uc002gfe.2_5'Flank|DULLARD_uc002gff.2_5'Flank|DULLARD_uc002gfc.2_5'Flank|C17orf81_uc002gfj.2_Nonsense_Mutation_p.E54*|C17orf81_uc010cmb.2_Nonsense_Mutation_p.E54*|C17orf81_uc002gfh.1_Nonsense_Mutation_p.E54*|C17orf81_uc002gfi.1_Nonsense_Mutation_p.E54*|C17orf81_uc002gfk.1_Nonsense_Mutation_p.E54*|C17orf81_uc002gfl.1_Nonsense_Mutation_p.E54*	NM_203415	NP_981960	Q8TE02	DERP6_HUMAN	S-phase 2 protein isoform 4	54					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding				0						CCTTAGTGGGGAGCAAGTGCA	0.507000													6	83					0.000274275	0.00213142	0.000274275	1	0
FXR2	9513	broad.mit.edu	37	17	7496150	7496151	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:7496150_7496151CC>TT	uc002gia.1	-	14	1817_1818	c.1590_1591GG>AA	c.(1588-1593)CCGGTT>CCAATT	p.V531I	SOX15_uc002ghy.1_5'Flank|SOX15_uc002ghz.1_5'Flank	NM_004860	NP_004851	P51116	FXR2_HUMAN	fragile X mental retardation syndrome related	531						cytosolic large ribosomal subunit	protein binding|RNA binding				0				READ - Rectum adenocarcinoma(115;0.17)		TCTGAATCAACCGGGGGCTCTG	0.614000													18	30					0	0	6.4e-05	0	0
LYZL6	57151	broad.mit.edu	37	17	34263770	34263770	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:34263770C>T	uc002hkj.1	-	3	516	c.366G>A	c.(364-366)GGG>GGA	p.G122G	LYZL6_uc002hkk.1_Silent_p.G122G	NM_020426	NP_065159	O75951	LYZL6_HUMAN	lysozyme-like 6 precursor	122					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTTGTTCATCCCCCGTGCTC	0.572000													28	47					0	0	0.000491102	0	0
NSF	4905	broad.mit.edu	37	17	44803964	44803964	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:44803964A>G	uc002iku.2	+	16	1915	c.1811A>G	c.(1810-1812)GAC>GGC	p.D604G	NSF_uc010wke.1_Missense_Mutation_p.D510G|NSF_uc010wkf.1_Missense_Mutation_p.D510G|NSF_uc010wkg.1_Missense_Mutation_p.D599G	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	604					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		GTTGTGGATGACATTGAGAGA	0.373000													3	117					0	0	6.4e-05	0	0
KIF2B	84643	broad.mit.edu	37	17	51900848	51900848	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:51900848G>A	uc002iua.2	+	1	610	c.454G>A	c.(454-456)GAA>AAA	p.E152K	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	152	Potential.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						CTGCCTCTGGGAAATCCAGAA	0.562000													24	39					0	0	0.000586117	0	0
USP32	84669	broad.mit.edu	37	17	58329766	58329766	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:58329766G>A	uc002iyo.1	-	11	1398	c.1112C>T	c.(1111-1113)CCG>CTG	p.P371L	USP32_uc002iyn.1_Missense_Mutation_p.P41L|USP32_uc010wov.1_Missense_Mutation_p.P371L	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	371	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			TTCTTCTTCCGGAGTAGCTGG	0.323000													13	18					0	0	0.000308642	0	0
CSHL1	1444	broad.mit.edu	37	17	61987583	61987583	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:61987583G>A	uc002jda.1	-	4	472	c.410C>T	c.(409-411)TCG>TTG	p.S137L	CSHL1_uc002jcz.1_Missense_Mutation_p.S114L|CSHL1_uc002jdb.1_Missense_Mutation_p.S43L|CSHL1_uc002jdc.1_Missense_Mutation_p.S54L|CSHL1_uc002jdd.1_Missense_Mutation_p.S75L|CSHL1_uc002jde.2_3'UTR|CSHL1_uc002jdf.2_Missense_Mutation_p.S54L|CSHL1_uc002jdg.2_3'UTR|CSHL1_uc002jdh.2_Missense_Mutation_p.S43L	NM_022579	NP_072101	Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	137						extracellular region	hormone activity|metal ion binding				0						ATCGCTGTCCGAGGTGTCATA	0.582000													14	20					0	0	0.000958276	0	0
ABCA8	10351	broad.mit.edu	37	17	66917522	66917522	+	Splice_Site	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:66917522C>T	uc002jhp.2	-	12	1791	c.1612_splice	c.e12+1	p.G538_splice	ABCA8_uc002jhq.2_Splice_Site_p.G538_splice|ABCA8_uc010wqq.1_Splice_Site_p.G538_splice|ABCA8_uc010wqr.1_Splice_Site_p.G477_splice|ABCA8_uc002jhr.2_Splice_Site_p.G538_splice	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8							integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					CTAGTTTGTACCTTTGGTGGG	0.254000													15	28					0	0	0.000219431	0	0
TSEN54	283989	broad.mit.edu	37	17	73517849	73517849	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr17:73517849C>T	uc002jof.1	+	8	720	c.687C>T	c.(685-687)TCC>TCT	p.S229S	TSEN54_uc002joe.1_3'UTR	NM_207346	NP_997229	Q7Z6J9	SEN54_HUMAN	tRNA splicing endonuclease 54 homolog	229					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	nucleolus				ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGGCAGCCTCCAGCCCACCTC	0.622000													5	9					0	0	8.12818e-05	0	0
LRRC30	339291	broad.mit.edu	37	18	7231222	7231222	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr18:7231222C>A	uc010wzk.1	+	1	86	c.86C>A	c.(85-87)CCG>CAG	p.P29Q		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	29										ovary(1)|liver(1)	2						AAGTTTTCTCCGTGGGACGAT	0.612000													20	20					8.34094e-07	6.54092e-06	0.00121646	1	0
C18orf1	753	broad.mit.edu	37	18	13645128	13645128	+	Silent	SNP	C	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr18:13645128C>A	uc002ksa.2	+	7	1061	c.393C>A	c.(391-393)ATC>ATA	p.I131I	C18orf1_uc002ksb.2_Silent_p.I113I|C18orf1_uc002kse.2_Silent_p.I94I|C18orf1_uc002ksf.2_Silent_p.I76I|C18orf1_uc002ksg.1_Silent_p.I54I|C18orf1_uc002ksh.1_Silent_p.I73I|C18orf1_uc002ksi.1_Silent_p.I55I	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	131	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		CCTTCCAGATCATGCATGCCC	0.537000													11	48					7.03913e-09	5.57084e-08	0.00136819	1	0
C18orf34	374864	broad.mit.edu	37	18	30950152	30950152	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr18:30950152C>T	uc002kxn.2	-	5	352	c.210G>A	c.(208-210)GGG>GGA	p.G70G	C18orf34_uc010xbr.1_Silent_p.G70G|C18orf34_uc010dmf.1_Silent_p.G70G|C18orf34_uc002kxo.2_Silent_p.G70G|C18orf34_uc002kxp.2_Silent_p.G70G	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	70										ovary(1)	1						CTTTATTCACCCCTAAAGAGA	0.343000													7	9					0	0	8.12818e-05	0	0
NEDD4L	23327	broad.mit.edu	37	18	55996240	55996240	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr18:55996240G>A	uc002lgy.2	+	10	968	c.694G>A	c.(694-696)GAG>AAG	p.E232K	NEDD4L_uc002lgz.2_Missense_Mutation_p.E232K|NEDD4L_uc002lgx.2_Missense_Mutation_p.E232K|NEDD4L_uc010xee.1_Missense_Mutation_p.E111K|NEDD4L_uc002lhc.2_Missense_Mutation_p.E224K|NEDD4L_uc002lhd.2_Missense_Mutation_p.E111K|NEDD4L_uc002lhb.2_Missense_Mutation_p.E111K|NEDD4L_uc002lhe.2_Missense_Mutation_p.E224K|NEDD4L_uc002lhf.2_Missense_Mutation_p.E111K|NEDD4L_uc002lhg.2_Missense_Mutation_p.E111K|NEDD4L_uc002lhh.2_Missense_Mutation_p.E111K|NEDD4L_uc010dpm.1_Missense_Mutation_p.E83K	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	232					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						CGTGTCCTCGGAGTCGGACAA	0.587000													8	16					0	0	0.000442599	0	0
MALT1	10892	broad.mit.edu	37	18	56376661	56376661	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr18:56376661C>T	uc002lhm.1	+	5	959	c.701C>T	c.(700-702)ACT>ATT	p.T234I	MALT1_uc002lhn.1_Missense_Mutation_p.T234I	NM_006785	NP_006776	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma	234	Ig-like C2-type 2.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			ovary(2)|lung(1)|central_nervous_system(1)	4						GTTGAACCAACTTCCCAAAAG	0.358000			T	BIRC3	MALT								18	38					0	0	0.00188189	0	0
CPLX4	339302	broad.mit.edu	37	18	56985686	56985686	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr18:56985686G>A	uc002lhy.2	-	1	196	c.9C>T	c.(7-9)TTC>TTT	p.F3F		NM_181654	NP_857637	Q7Z7G2	CPLX4_HUMAN	complexin 4 precursor	3					exocytosis|neurotransmitter transport	cell junction|synapse	syntaxin binding			ovary(1)	1		Colorectal(73;0.175)				TTTTCATAAGGAAAGCCATTT	0.363000													17	20					0	0	0.000422831	0	0
MIER2	54531	broad.mit.edu	37	19	326549	326549	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:326549G>A	uc002lok.1	-	6	552	c.543C>T	c.(541-543)TCC>TCT	p.S181S		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGGTGTCGGAGGAGGCAG	0.592000													24	43					0	0	0.000878237	0	0
SBNO2	22904	broad.mit.edu	37	19	1119085	1119085	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:1119085G>A	uc002lrk.3	-	14	1690	c.1452C>T	c.(1450-1452)TCC>TCT	p.S484S	SBNO2_uc002lrj.3_Silent_p.S427S|SBNO2_uc010dse.2_Silent_p.S477S|SBNO2_uc010xgj.1_Intron|SBNO2_uc010dsf.2_Silent_p.S427S	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	484					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGACGCCGGAGAAGCTGA	0.682000													3	4					0	0	0.00024832	0	0
BTBD2	55643	broad.mit.edu	37	19	1997393	1997393	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:1997393C>T	uc002lup.1	-	2	477	c.477G>A	c.(475-477)ACG>ACA	p.T159T		NM_017797	NP_060267	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	159	BTB.					cytoplasmic mRNA processing body	protein binding			ovary(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCAATCTCCGTGGATGTTG	0.622000													29	48					0	0	0.00127121	0	0
TBXA2R	6915	broad.mit.edu	37	19	3600066	3600066	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:3600066G>A	uc002lyg.1	-	2	781	c.567C>T	c.(565-567)GCC>GCT	p.A189A	TBXA2R_uc002lye.1_Intron	NM_001060	NP_001051	P21731	TA2R_HUMAN	thromboxane A2 receptor isoform alpha	189	Extracellular (Potential).				platelet activation	integral to plasma membrane	guanyl-nucleotide exchange factor activity|protein binding|thromboxane A2 receptor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)	Ridogrel(DB01207)	CCCCGGACTCGGCGCCCAGCG	0.711000													5	16					0	0	0.000274275	0	0
TJP3	27134	broad.mit.edu	37	19	3746033	3746033	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:3746033C>T	uc010xhv.1	+	15	2063	c.2063C>T	c.(2062-2064)CCC>CTC	p.P688L	TJP3_uc010xhs.1_Missense_Mutation_p.P655L|TJP3_uc010xht.1_Missense_Mutation_p.P619L|TJP3_uc010xhu.1_Missense_Mutation_p.P664L|TJP3_uc010xhw.1_Missense_Mutation_p.P674L	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	669	Guanylate kinase-like.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCGACAGCCCCTCCAAGATC	0.592000													4	5					0	0	0.000602214	0	0
PLIN4	729359	broad.mit.edu	37	19	4513645	4513645	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:4513645C>T	uc002mar.1	-	3	285	c.285G>A	c.(283-285)GGG>GGA	p.G95G	PLIN4_uc010dub.1_5'Flank	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	95	1.|27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane					0						CGCTGGCCACCCCGGAGGACA	0.627000													3	3					0	0	6.4e-05	0	0
LRRC8E	80131	broad.mit.edu	37	19	7964028	7964028	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:7964028G>A	uc002mir.2	+	3	722	c.621G>A	c.(619-621)CTG>CTA	p.L207L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	207						integral to membrane				lung(1)|pancreas(1)	2						AGAAAGTGCTGGCGGAACCGG	0.622000													4	24					0	0	0.00024832	0	0
OR1M1	125963	broad.mit.edu	37	19	9204819	9204819	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:9204819C>T	uc010xkj.1	+	1	899	c.899C>T	c.(898-900)GCT>GTT	p.A300V		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						CTGAAAGGGGCTCTCAGGAAG	0.512000													6	22					0	0	8.12818e-05	0	0
ZNF560	147741	broad.mit.edu	37	19	9578233	9578233	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:9578233C>T	uc002mlp.1	-	10	1600	c.1390G>A	c.(1390-1392)GAA>AAA	p.E464K	ZNF560_uc010dwr.1_Missense_Mutation_p.E358K	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						TTCCCATATTCCTTATGCTCA	0.403000													46	192					0	0	0.000781405	0	0
ZNF563	147837	broad.mit.edu	37	19	12429881	12429881	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:12429881G>A	uc002mtp.2	-	4	1196	c.958C>T	c.(958-960)CAT>TAT	p.H320Y		NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	320	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCCAAGATGATGAAATGTT	0.438000													19	54					0	0	0.000958276	0	0
NFIX	4784	broad.mit.edu	37	19	13136080	13136080	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:13136080C>T	uc010xmx.1	+	2	350	c.297C>T	c.(295-297)TTC>TTT	p.F99F	NFIX_uc002mwd.2_Silent_p.F91F|NFIX_uc002mwe.2_Silent_p.F83F|NFIX_uc002mwf.2_Silent_p.F94F|NFIX_uc002mwg.1_Silent_p.F90F			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	91	CTF/NF-I.			F -> Y (in Ref. 1; AAA53422).	DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			GCGAGGACTTCGTGCTGACCA	0.652000													11	19					0	0	0.000978159	0	0
CACNA1A	773	broad.mit.edu	37	19	13397745	13397745	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:13397745G>A	uc010dze.2	-	20	3364	c.3128C>T	c.(3127-3129)CCC>CTC	p.P1043L	CACNA1A_uc010dzc.2_Missense_Mutation_p.P568L|CACNA1A_uc002mwy.3_Missense_Mutation_p.P1042L|CACNA1A_uc010xne.1_Missense_Mutation_p.P571L	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1043	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGACAGGTTGGGGCCCGACAC	0.552000													14	20					0	0	0.000422831	0	0
SLC1A6	6511	broad.mit.edu	37	19	15073094	15073094	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:15073094C>T	uc002naa.1	-	5	663	c.655G>A	c.(655-657)GAG>AAG	p.E219K	SLC1A6_uc010dzu.1_Missense_Mutation_p.E219K|SLC1A6_uc010xod.1_Missense_Mutation_p.E155K|SLC1A6_uc002nab.2_Missense_Mutation_p.E219K|SLC1A6_uc002nac.2_Missense_Mutation_p.E219K	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	219	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	GCACCCGGCTCAGACCCGTTC	0.537000													27	69					0	0	0.000339439	0	0
OR1I1	126370	broad.mit.edu	37	19	15198755	15198755	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:15198755G>A	uc010xoe.1	+	1	879	c.879G>A	c.(877-879)CGG>CGA	p.R293R		NM_001004713	NP_001004713	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3						ACAGCATACGGAACAAGGATA	0.488000													14	34					0	0	0.000422831	0	0
CPAMD8	27151	broad.mit.edu	37	19	17119350	17119350	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:17119350A>C	uc002nfb.2	-	7	697	c.665T>G	c.(664-666)ATG>AGG	p.M222R		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	175						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCACTCTATCATCCGAGAGCC	0.527000													8	17					0	0	0.000978159	0	0
PLVAP	83483	broad.mit.edu	37	19	17476311	17476311	+	Silent	SNP	C	T	T	rs150210307		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:17476311C>T	uc002ngk.1	-	3	1013	c.963G>A	c.(961-963)GCG>GCA	p.A321A		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	321	Potential.|Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						CCTTCTGTTTCGCCTCCTGAC	0.667000													15	18					0	0	0.000219431	0	0
ZNF99	7652	broad.mit.edu	37	19	22940373	22940373	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:22940373T>C	uc010xrh.1	-	5	2065	c.2065A>G	c.(2065-2067)AAG>GAG	p.K689E		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TGAATTATCTTATGTTTTCTA	0.343000													4	44					0	0	0.00024832	0	0
RYR1	6261	broad.mit.edu	37	19	39023320	39023320	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:39023320C>T	uc002oit.2	+	78	11333	c.11203C>T	c.(11203-11205)CTG>TTG	p.L3735L	RYR1_uc002oiu.2_Silent_p.L3730L|RYR1_uc002oiv.1_Silent_p.L650L|RYR1_uc010xuf.1_Silent_p.L655L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3735					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GAGCTGCCACCTGGAGGAGGG	0.617000													9	29					0	0	0.000978159	0	0
ERCC1	2067	broad.mit.edu	37	19	45924637	45924637	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:45924637G>A	uc002pbs.1	-	3	266	c.120C>T	c.(118-120)TTC>TTT	p.F40F	ERCC1_uc002pbt.1_Silent_p.F40F|ERCC1_uc002pbu.1_Intron|ERCC1_uc002pbv.2_Silent_p.F40F	NM_001983	NP_001974	P07992	ERCC1_HUMAN	excision repair cross-complementing 1 isofrom 2	40					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			ovary(2)	2		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		GTGTAGATCGGAATAAGGGCT	0.597000								NER					18	19					0	0	0.000566183	0	0
NLRP13	126204	broad.mit.edu	37	19	56423937	56423937	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:56423937C>T	uc010ygg.1	-	5	1271	c.1246G>A	c.(1246-1248)GAA>AAA	p.E416K		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	416	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		AAGAGAGTTTCGTTTTTTCTT	0.463000													6	20					0	0	0.00116845	0	0
FAM110C	642273	broad.mit.edu	37	2	41615	41615	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:41615G>A	uc010yim.1	-	2	959	c.959C>T	c.(958-960)TCC>TTC	p.S320F		NM_001077710	NP_001071178	Q1W6H9	F110C_HUMAN	hypothetical protein LOC642273	320						microtubule|microtubule organizing center|spindle pole					0	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		TCATCATCGGGAAGGTTTGCT	0.408000													19	32					0	0	0.00121646	0	0
C2orf53	339779	broad.mit.edu	37	2	27360866	27360866	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:27360866G>A	uc002rjb.2	-	3	912	c.332C>T	c.(331-333)TCC>TTC	p.S111F		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	111	Pro-rich.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ggagggagaggatgcacgtgg	0.164000													4	3					0	0	0.00024832	0	0
ALK	238	broad.mit.edu	37	2	29432682	29432682	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:29432682C>T	uc002rmy.2	-	25	4713	c.3806G>A	c.(3805-3807)GGA>GAA	p.G1269E	ALK_uc010ymo.1_Missense_Mutation_p.G201E	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1269	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CCCGAAGTCTCCAATCTTGGC	0.542000			T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				24	34					0	0	0.00127121	0	0
HEATR5B	54497	broad.mit.edu	37	2	37283665	37283665	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:37283665G>A	uc002rpp.1	-	16	2413	c.2317C>T	c.(2317-2319)CCC>TCC	p.P773S		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	773							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				AGAGGGAGGGGACCAGGTACT	0.478000													12	40					0	0	0.00185496	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43968180	43968180	+	Silent	SNP	C	T	T	rs113125573		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:43968180C>T	uc010yny.1	+	21	3302	c.3219C>T	c.(3217-3219)TCC>TCT	p.S1073S	PLEKHH2_uc002rtf.3_Silent_p.S1072S	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1073	MyTH4.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				ATGCAGATTCCAGGTGTGCAG	0.488000													20	52					0	0	0.00188189	0	0
USP34	9736	broad.mit.edu	37	2	61512070	61512070	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:61512070C>T	uc002sbe.2	-	35	4794	c.4772G>A	c.(4771-4773)GGA>GAA	p.G1591E		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1591					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CAAACTGGTTCCTTGGACAAG	0.308000													4	21					0	0	0.000602214	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69009419	69009419	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:69009419G>A	uc002seu.2	+	3	680	c.316G>A	c.(316-318)GAA>AAA	p.E106K	ARHGAP25_uc010yqk.1_Missense_Mutation_p.E80K|ARHGAP25_uc010fdg.2_Missense_Mutation_p.E106K|ARHGAP25_uc010yql.1_Missense_Mutation_p.E106K|ARHGAP25_uc002sev.2_Missense_Mutation_p.E99K|ARHGAP25_uc002sew.2_Missense_Mutation_p.E99K|ARHGAP25_uc002sex.2_Missense_Mutation_p.E99K|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	106	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						AAACCCAGAAGAAGCTGGGAA	0.443000													19	57					0	0	0.000295444	0	0
AUP1	550	broad.mit.edu	37	2	74754932	74754932	+	Translation_Start_Site	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:74754932G>A	uc002sme.2	-	1	368	c.-29C>T	c.(-31--27)CACGG>CATGG		DQX1_uc010yrw.1_5'Flank|AUP1_uc002smf.2_Missense_Mutation_p.R258W|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.R167W|AUP1_uc010yrx.1_Missense_Mutation_p.R315W|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	Homo sapiens AUP1 homolog mRNA, complete cds.							endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						GGAGTGAGCCGTGTCCCTGTC	0.532000													38	61					0	0	0.00148497	0	0
MGAT4A	11320	broad.mit.edu	37	2	99251692	99251692	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:99251692G>A	uc002sze.2	-	14	1775	c.1461C>T	c.(1459-1461)TTC>TTT	p.F487F	C2orf64_uc002sza.2_Intron|MGAT4A_uc010yvm.1_Silent_p.F359F|MGAT4A_uc010fil.2_Silent_p.F241F	NM_012214	NP_036346	Q9UM21	MGT4A_HUMAN	alpha-1,3-mannosyl-glycoprotein	487	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1						TACCTATTCTGAAATAGCCAT	0.289000													7	19					0	0	8.12818e-05	0	0
C2orf40	84417	broad.mit.edu	37	2	106694260	106694260	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:106694260C>T	uc010fjf.2	+	4	433	c.325C>T	c.(325-327)CGA>TGA	p.R109*		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	109						extracellular region|transport vesicle					0						TAACAGAGATCGAAATGGACA	0.453000													22	29					0	0	0.000878237	0	0
RGPD4	285190	broad.mit.edu	37	2	108487716	108487716	+	Nonsense_Mutation	SNP	A	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:108487716A>T	uc010ywk.1	+	20	3338	c.3256A>T	c.(3256-3258)AAA>TAA	p.K1086*	RGPD4_uc002tdu.2_Nonsense_Mutation_p.K273*|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1086	RanBD1 1.				intracellular transport		binding			skin(2)	2						GGGGAACTTAAAAATTCTCAA	0.393000													69	207					0	0	0.000781405	0	0
MAP3K2	10746	broad.mit.edu	37	2	128081558	128081558	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:128081558G>A	uc002toj.1	-	10	823	c.758C>T	c.(757-759)CCT>CTT	p.P253L	MAP3K2_uc010flz.1_Missense_Mutation_p.P253L	NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	253					activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		CTCAAAGATAGGGTTATCATA	0.254000													7	11					0	0	8.12818e-05	0	0
CCDC74B	91409	broad.mit.edu	37	2	130897892	130897892	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:130897892G>A	uc002tqm.1	-	5	798	c.736C>T	c.(736-738)CAG>TAG	p.Q246*	CCDC74B_uc010yzw.1_Nonsense_Mutation_p.Q348*|CCDC74B_uc002tqn.1_Nonsense_Mutation_p.Q180*	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	246											0	Colorectal(110;0.1)					CCCTGGTGCTGGCTGTTCCCC	0.612000													28	45					0	0	0.000409698	0	0
ZEB2	9839	broad.mit.edu	37	2	145147101	145147101	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:145147101G>A	uc002tvu.2	-	10	4042	c.3562C>T	c.(3562-3564)CAC>TAC	p.H1188Y	ZEB2_uc002tvv.2_Missense_Mutation_p.H1182Y|ZEB2_uc010zbm.1_Missense_Mutation_p.H1159Y|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1188	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TCCATGGAGTGATCTCCAGTC	0.438000													71	90					0	0	0.000781405	0	0
FMNL2	114793	broad.mit.edu	37	2	153399257	153399257	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:153399257G>A	uc002tye.2	+	3	573	c.206G>A	c.(205-207)CGA>CAA	p.R69Q		NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	formin-like 2	69	GBD/FH3.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|ovary(1)	3						CTGCAGGAACGATTCCAGGTG	0.418000													10	34					0	0	0.000978159	0	0
SLC4A10	57282	broad.mit.edu	37	2	162719562	162719562	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:162719562G>A	uc002ubx.3	+	6	940	c.756G>A	c.(754-756)ATG>ATA	p.M252I	SLC4A10_uc010fpa.1_Missense_Mutation_p.M264I|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.M252I|SLC4A10_uc010zcs.1_Missense_Mutation_p.M263I	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	252	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CAAATTCCATGGACAAAAATG	0.338000													4	18					0	0	0.00024832	0	0
SCN7A	6332	broad.mit.edu	37	2	167262185	167262185	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:167262185G>A	uc002udu.1	-	25	5081	c.4954C>T	c.(4954-4956)CAT>TAT	p.H1652Y		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1652					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TCTATCATATGAATATCTGAT	0.363000													62	100					0	0	0.000781405	0	0
XIRP2	129446	broad.mit.edu	37	2	168103996	168103996	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:168103996C>T	uc002udx.2	+	8	6112	c.6094C>T	c.(6094-6096)CGT>TGT	p.R2032C	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R1857C|XIRP2_uc010fpq.2_Missense_Mutation_p.R1810C|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1857					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGTCATAGATCGTGAACAAAA	0.388000													7	23					0	0	8.12818e-05	0	0
TTN	7273	broad.mit.edu	37	2	179597846	179597846	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:179597846G>A	uc010zfg.1	-	52	12549	c.12325C>T	c.(12325-12327)CGA>TGA	p.R4109*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.R770*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5036							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAATGTCTCGATCTGTGTGT	0.443000													9	10					0	0	0.000274275	0	0
NCKAP1	10787	broad.mit.edu	37	2	183800042	183800042	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:183800042C>G	uc002upc.2	-	25	3159	c.2757G>C	c.(2755-2757)TTG>TTC	p.L919F	NCKAP1_uc002upb.2_Missense_Mutation_p.L925F	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	919					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CTTCTTGTGCCAATGATCGGA	0.328000													3	41					0	0	0.00024832	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800682	185800682	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:185800682C>T	uc002uph.2	+	4	1153	c.559C>T	c.(559-561)CCA>TCA	p.P187S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	187						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGCTGAAGATCCAGAAAGTGC	0.363000													6	22					0	0	8.12818e-05	0	0
COL3A1	1281	broad.mit.edu	37	2	189868749	189868749	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:189868749G>A	uc002uqj.1	+	39	2820	c.2703G>A	c.(2701-2703)AAG>AAA	p.K901K		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	901	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTCCAGGCAAGGATGGGCCCC	0.502000													12	2					0	0	0.000978159	0	0
DNAH7	56171	broad.mit.edu	37	2	196619217	196619217	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:196619217G>A	uc002utj.3	-	63	11709	c.11608C>T	c.(11608-11610)CCT>TCT	p.P3870S	DNAH7_uc002uti.3_Missense_Mutation_p.P353S	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3870					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AAGACTGGAGGAGGACCAACC	0.403000													9	11					0	0	0.000978159	0	0
NBEAL1	65065	broad.mit.edu	37	2	203906494	203906494	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:203906494C>T	uc002uzt.3	+	3	391	c.58C>T	c.(58-60)CCA>TCA	p.P20S	NBEAL1_uc002uzq.3_Missense_Mutation_p.P20S|NBEAL1_uc010zid.1_5'UTR|NBEAL1_uc010zie.1_RNA	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	20							binding			ovary(1)|skin(1)	2						TCAGAAAGATCCAGATTACCT	0.338000													51	255					0	0	0.000781405	0	0
ZDBF2	57683	broad.mit.edu	37	2	207146584	207146584	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:207146584G>A	uc002vbp.2	+	3	261	c.11G>A	c.(10-12)AGA>AAA	p.R4K		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	4	DBF4-type.						nucleic acid binding|zinc ion binding			ovary(3)	3						ATGCAGAAAAGACAAGGATAT	0.338000													12	29					0	0	0.000566183	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174275	207174275	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:207174275C>T	uc002vbp.2	+	5	5273	c.5023C>T	c.(5023-5025)CGA>TGA	p.R1675*		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1675							nucleic acid binding|zinc ion binding			ovary(3)	3						CACTTCTCATCGAACGACTCA	0.408000													25	22					0	0	0.000878237	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	A	A	rs121913500		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:209113112C>A	uc002vcs.2	-	4	641	c.395G>T	c.(394-396)CGT>CTT	p.R132L	IDH1_uc002vct.2_Missense_Mutation_p.R132L|IDH1_uc002vcu.2_Missense_Mutation_p.R132L	NM_005896	NP_005887	O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132		Substrate.	R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2023)|p.R132C(344)|p.R132?(210)|p.R132G(117)|p.R132S(79)|p.R132L(58)|p.R132V(1)|p.G131_R132>VL(1)		central_nervous_system(2156)|haematopoietic_and_lymphoid_tissue(606)|bone(74)|thyroid(22)|large_intestine(4)|skin(2)|prostate(2)|autonomic_ganglia(1)|soft_tissue(1)	2868				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma 								16	22					9.16793e-09	7.23341e-08	0.000566183	1	0
DES	1674	broad.mit.edu	37	2	220286118	220286118	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:220286118C>T	uc002vll.2	+	6	1166	c.1080C>T	c.(1078-1080)GCC>GCT	p.A360A		NM_001927	NP_001918	P17661	DESM_HUMAN	desmin	360	Rod.|Coil 2B.		Missing (in MFM1).|A -> P (in MFM1; heterozygous with Ile- 391 gives a severe childhood-onset; unable to form a filamentous network; abolishes binding to MTM1).		cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			central_nervous_system(2)	2		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		CCAGTGAGGCCAGTGGCTACC	0.597000													12	22					0	0	0.000978159	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883978	228883978	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:228883978C>T	uc002vpq.2	-	7	1639	c.1592G>A	c.(1591-1593)GGG>GAG	p.G531E	SPHKAP_uc002vpp.2_Missense_Mutation_p.G531E|SPHKAP_uc010zlx.1_Missense_Mutation_p.G531E	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	531						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACCACTGCTCCCTGGGGGAAA	0.512000													9	27					0	0	0.000274275	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884573	228884573	+	Missense_Mutation	SNP	C	T	T	rs148914025		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:228884573C>T	uc002vpq.2	-	7	1044	c.997G>A	c.(997-999)GAA>AAA	p.E333K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E333K|SPHKAP_uc010zlx.1_Missense_Mutation_p.E333K	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	333						cytoplasm	protein binding	p.E333K(1)		skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGTGATTTTTCCATTTGACCT	0.428000													16	47					0	0	0.000308642	0	0
ANKMY1	51281	broad.mit.edu	37	2	241452226	241452226	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr2:241452226G>A	uc002vyz.1	-	9	2100	c.1871C>T	c.(1870-1872)CCC>CTC	p.P624L	ANKMY1_uc002vza.1_Missense_Mutation_p.P483L|ANKMY1_uc010fzd.1_Missense_Mutation_p.P713L|ANKMY1_uc002vzb.1_Missense_Mutation_p.P385L|ANKMY1_uc002vzc.1_Missense_Mutation_p.P483L|ANKMY1_uc002vzd.1_Missense_Mutation_p.P483L	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	624							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CACCTTGCCGGGCTTGTAAGT	0.612000													4	6					0	0	0.000157383	0	0
ANGPT4	51378	broad.mit.edu	37	20	858863	858863	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:858863G>A	uc002wei.2	-	7	1264	c.1161C>T	c.(1159-1161)GGC>GGT	p.G387G	ANGPT4_uc010zpn.1_Silent_p.G381G	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	387	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						AGGCCTCGTGGCCTTCCCAGT	0.622000													7	15					0	0	8.12818e-05	0	0
HSPA12B	116835	broad.mit.edu	37	20	3728871	3728871	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:3728871T>C	uc002wjd.2	+	8	786	c.683T>C	c.(682-684)CTA>CCA	p.L228P	HSPA12B_uc010zqi.1_Missense_Mutation_p.L227P|HSPA12B_uc002wje.2_Missense_Mutation_p.L141P|HSPA12B_uc010zqj.1_Missense_Mutation_p.L62P	NM_052970	NP_443202	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	228							ATP binding				0						CAGGCTGGACTAGTGTCCCGA	0.657000													13	33					0	0	0.000422831	0	0
BFSP1	631	broad.mit.edu	37	20	17495447	17495447	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:17495447G>A	uc002wpo.2	-	3	492	c.453C>T	c.(451-453)GCC>GCT	p.A151A	BFSP1_uc002wpp.2_Silent_p.A26A|BFSP1_uc010zrn.1_Silent_p.A12A|BFSP1_uc010zro.1_Silent_p.A12A	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	151	Rod.|Coil 1B.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						TATGCAGCAAGGCTTCATCAG	0.473000													15	60					0	0	0.000422831	0	0
CEP250	11190	broad.mit.edu	37	20	34091513	34091513	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:34091513C>T	uc002xcm.2	+	31	5987	c.5316C>T	c.(5314-5316)CTC>CTT	p.L1772L	CEP250_uc010zve.1_Silent_p.L1140L	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1772	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CCAGCCTCCTCCTGTCCCAGC	0.572000													19	36					0	0	0.00074312	0	0
SGK2	10110	broad.mit.edu	37	20	42196349	42196349	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:42196349G>A	uc002xkv.2	+	3	530	c.311G>A	c.(310-312)GGG>GAG	p.G104E	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.G44E|SGK2_uc010ggm.2_Missense_Mutation_p.G44E|SGK2_uc002xks.2_Missense_Mutation_p.G44E|SGK2_uc002xku.2_Missense_Mutation_p.G44E|SGK2_uc002xkq.1_Missense_Mutation_p.G44E	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	104	ATP (By similarity).|Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ATCGGCAAAGGGAACTACGGG	0.552000													15	27					0	0	0.000566183	0	0
C20orf200	253868	broad.mit.edu	37	20	61143446	61143447	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:61143446_61143447CC>TT	uc002ycz.1	-	3	892_893	c.401_402GG>AA	c.(400-402)AGG>AAA	p.R134K	C20orf200_uc002ycy.2_RNA	NM_152757	NP_689970			hypothetical protein LOC253868												0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;7.17e-06)			GGGACCCTCACCTTGACTGTGT	0.658000													14	23					0	0	6.4e-05	0	0
NTSR1	4923	broad.mit.edu	37	20	61386080	61386080	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:61386080C>T	uc002ydf.2	+	2	1129	c.758C>T	c.(757-759)TCG>TTG	p.S253L		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	253	Helical; Name=5; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			GTGGTCATCTCGGTCCTGAAC	0.607000													23	73					0	0	0.000375601	0	0
DIDO1	11083	broad.mit.edu	37	20	61512461	61512461	+	Missense_Mutation	SNP	G	A	A	rs140993487	by1000genomes	TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:61512461G>A	uc002ydr.1	-	16	5111	c.4847C>T	c.(4846-4848)TCT>TTT	p.S1616F	DIDO1_uc002yds.1_Missense_Mutation_p.S1616F	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1616					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCAGGGGGAAGAGGCTGGCTC	0.711000													6	9					0	0	8.12818e-05	0	0
DIDO1	11083	broad.mit.edu	37	20	61542327	61542327	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:61542327A>G	uc002ydr.1	-	3	902	c.638T>C	c.(637-639)CTG>CCG	p.L213P	DIDO1_uc002yds.1_Missense_Mutation_p.L213P|DIDO1_uc002ydt.1_Missense_Mutation_p.L213P|DIDO1_uc002ydu.1_Missense_Mutation_p.L213P|DIDO1_uc002ydv.1_Missense_Mutation_p.L213P|DIDO1_uc002ydw.1_Missense_Mutation_p.L213P|DIDO1_uc002ydx.1_Missense_Mutation_p.L213P|DIDO1_uc011aao.1_Missense_Mutation_p.L213P	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	213					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTACTGGGCAGGACGCCCTC	0.632000													12	29					0	0	0.00185496	0	0
EEF1A2	1917	broad.mit.edu	37	20	62121960	62121960	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:62121960C>T	uc002yfd.1	-	5	1002	c.901G>A	c.(901-903)GAA>AAA	p.E301K	EEF1A2_uc002yfe.1_Missense_Mutation_p.E301K|EEF1A2_uc010gkg.1_Missense_Mutation_p.E301K	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	301						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			GGCAGAGCTTCGCTCAGAGCC	0.622000													22	28					0	0	0.000375601	0	0
RTEL1	51750	broad.mit.edu	37	20	62326551	62326551	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr20:62326551T>C	uc002yfu.1	+	33	3819	c.3476T>C	c.(3475-3477)CTT>CCT	p.L1159P	RTEL1_uc002yft.1_Missense_Mutation_p.L1159P|RTEL1_uc011abd.1_Missense_Mutation_p.L1183P|RTEL1_uc011abe.1_Missense_Mutation_p.L936P|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.L404P|TNFRSF6B_uc002yfy.2_5'UTR|TNFRSF6B_uc002yfz.2_5'Flank	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	1159					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CCTCCTGTGCTTACCCACAGG	0.697000													5	14					0	0	0.000602214	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28296553	28296553	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr21:28296553C>T	uc002ymg.2	-	8	3341	c.2612G>A	c.(2611-2613)GGA>GAA	p.G871E		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	871	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AGTGTGTGATCCCACTTTATT	0.522000													25	45					0	0	0.000878237	0	0
SLC5A3	6526	broad.mit.edu	37	21	35468588	35468589	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr21:35468588_35468589GG>TT	uc002yto.2	+	2	1603_1604	c.1091_1092GG>TT	c.(1090-1092)CGG>CTT	p.R364L	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	364	Helical; (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						GTGGGCCTTCGGGGTTTAATGA	0.485000													11	422					0	0	6.4e-05	0	0
LRRC3	81543	broad.mit.edu	37	21	45877008	45877008	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr21:45877008A>G	uc002zfa.2	+	2	774	c.481A>G	c.(481-483)AAG>GAG	p.K161E		NM_030891	NP_112153	Q9BY71	LRRC3_HUMAN	leucine-rich repeat-containing 3 precursor	161						integral to membrane	protein binding				0		Breast(209;0.00908)		COAD - Colon adenocarcinoma(84;0.148)|Lung(125;0.195)		GTGGGAGCTGAAGCTGGACCC	0.647000													7	18					0	0	8.12818e-05	0	0
PI4KA	5297	broad.mit.edu	37	22	21159290	21159290	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr22:21159290G>A	uc002zsz.3	-	11	1389	c.1158C>T	c.(1156-1158)CTC>CTT	p.L386L	PI4KA_uc010gsq.1_Silent_p.L444L	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	386					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			CCCACACCATGAGGTCCACAC	0.577000													20	29					0	0	0.000878237	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226868	24226868	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr22:24226868C>T	uc002zyn.3	+	12	1422	c.1323C>T	c.(1321-1323)TTC>TTT	p.F441F	SLC2A11_uc002zym.3_Silent_p.F448F|SLC2A11_uc002zyo.3_RNA|SLC2A11_uc011ajc.1_Missense_Mutation_p.S448F|SLC2A11_uc002zyp.3_Silent_p.F444F	NM_001024938	NP_001020109	Q9BYW1	GTR11_HUMAN	glucose transporter protein 10 isoform c	441	Helical; Name=12; (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity			ovary(1)	1						ATGTCCCTTTCCTTGGTGTCT	0.512000													35	60					0	0	0.000692331	0	0
MOV10L1	54456	broad.mit.edu	37	22	50582642	50582642	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr22:50582642C>T	uc003bjj.2	+	18	2558	c.2475C>T	c.(2473-2475)GTC>GTT	p.V825V	MOV10L1_uc003bjk.3_Silent_p.V825V|MOV10L1_uc011arp.1_Silent_p.V805V|MOV10L1_uc003bjl.2_5'Flank	NM_018995	NP_061868	Q9BXT6	M10L1_HUMAN	MOV10-like 1 isoform 1	825					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			ovary(2)|skin(1)	3		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CCACCATGGTCCGGGTGAACG	0.617000													12	23					0	0	0.000978159	0	0
GRM7	2917	broad.mit.edu	37	3	7188320	7188320	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:7188320G>A	uc003bqm.2	+	2	975	c.701G>A	c.(700-702)GGT>GAT	p.G234D	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.G234D|GRM7_uc003bql.2_Missense_Mutation_p.G234D	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	234	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GGAGAGAAAGGTGTGGAGTCC	0.498000													11	32					0	0	0.00185496	0	0
PPARG	5468	broad.mit.edu	37	3	12393094	12393094	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:12393094G>A	uc003bwx.2	+	1	94	c.3G>A	c.(1-3)ATG>ATA	p.M1I	PPARG_uc003bwr.2_Intron|PPARG_uc003bws.2_Intron|PPARG_uc003bwu.2_Intron|PPARG_uc003bwv.2_Intron|PPARG_uc003bwq.1_Intron|PPARG_uc010hdz.1_Intron|PPARG_uc003bwt.1_Intron|PPARG_uc003bww.1_Missense_Mutation_p.M1I	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	1					activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	ATGCTGTTATGGGTGAAACTC	0.393000			T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						92	199					0	0	0.000781405	0	0
TBC1D5	9779	broad.mit.edu	37	3	17202654	17202654	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:17202654G>A	uc003cbf.2	-	22	3854	c.2189C>T	c.(2188-2190)TCC>TTC	p.S730F	TBC1D5_uc010heu.2_Missense_Mutation_p.S317F|TBC1D5_uc010hev.2_Missense_Mutation_p.S752F|TBC1D5_uc003cbe.2_Missense_Mutation_p.S730F	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	730						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GCCGGAGAAGGAGCCCCTGGC	0.572000													10	22					0	0	0.000442599	0	0
SCN10A	6336	broad.mit.edu	37	3	38748782	38748782	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:38748782G>A	uc003ciq.2	-	25	4374	c.4374C>T	c.(4372-4374)ATC>ATT	p.I1458I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1458					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGGGCCGTGGGATGGGCTTCT	0.557000													30	70					0	0	0.000814825	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266125	41266125	+	Missense_Mutation	SNP	C	T	T	rs121913413		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:41266125C>T	uc010hia.1	+	4	278	c.122C>T	c.(121-123)ACC>ATC	p.T41I	CTNNB1_uc003ckp.2_Missense_Mutation_p.T41I|CTNNB1_uc003ckq.2_Missense_Mutation_p.T41I|CTNNB1_uc003ckr.2_Missense_Mutation_p.T41I|CTNNB1_uc011azf.1_Missense_Mutation_p.T34I|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	41			T -> I (in PTR, hepatocellular carcinoma and ovarian cancer).|T -> A (in hepatoblastoma and hepatocellular carcinoma; also in a desmoid tumor; strongly reduces phosphorylation and degradation; abolishes phosphorylation on Ser-33 and Ser-37 and enhances transactivation of target genes).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.T41A(466)|p.T41I(66)|p.A5_A80del(63)|p.H24_S47del(9)|p.A5_Q143del(7)|p.A5_A80>D(7)|p.Q28_H134del(5)|p.T41S(5)|p.T41N(4)|p.T41P(4)|p.W25_I140del(4)|p.V22_L139>V(2)|p.T3_A126del(2)|p.A5fs*7(2)|p.D32_S47del(2)|p.T41T(2)|p.M5_N141>D(2)|p.?(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A5_Q72del(1)|p.A20_Q143del(1)|p.A5_Q143>E(1)|p.A20_Q72del(1)|p.A13_R151del(1)|p.H36_E53>L(1)|p.M14_S45del(1)|p.T40_L46del(1)|p.A5_G80>(1)|p.A20_N141del(1)|p.M8_G50del(1)|p.M1_A87del(1)|p.D11_Y142>H(1)|p.D6_A43del(1)|p.A5_T42del(1)|p.V22_G80>NNNNN(1)|p.I35_T41del(1)|p.I35_K170del(1)|p.Y30_A97del(1)|p.V22_T102del(1)|p.A20_A80del(1)|p.V22_S71>A(1)|p.D6_K133del(1)|p.Q28_A43del(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.A5_R90del(1)|p.W25_A80del(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.A5_D144>D(1)|p.A20_R151del(1)|p.L7_I140del(1)|p.G38_S45del(1)|p.M8_A80del(1)|p.E9_A80del(1)|p.K19_Y142>V(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.V22_A80del(1)|p.A21_A80del(1)|p.E9_I140del(1)|p.P16_K133del(1)|p.V22_Y64del(1)|p.M1_T42del(1)|p.D6_I140del(1)|p.Q28_Q61del(1)|p.A20_L148del(1)|p.A39_T42del(1)|p.Q28_I140del(1)|p.S23_I140del(1)|p.A20_S111del(1)|p.E9_S47del(1)|p.Y30_A80del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GGTGCCACTACCACAGCTCCT	0.507000		15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				12	25					0	0	0.00136819	0	0
C3orf39	84892	broad.mit.edu	37	3	43122216	43122216	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:43122216G>A	uc003cmq.1	-	2	849	c.708C>T	c.(706-708)CTC>CTT	p.L236L	C3orf39_uc003cmr.1_Silent_p.L236L	NM_032806	NP_116195	Q8NAT1	AGO61_HUMAN	glycosyltransferase precursor	236						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)|skin(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0571)|Kidney(284;0.0718)		TGATCTTGGAGAGGCCCACAA	0.602000													22	33					0	0	0.000375601	0	0
TDGF1	6997	broad.mit.edu	37	3	46620758	46620758	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:46620758G>A	uc003cpv.2	+	3	405	c.125G>A	c.(124-126)GGA>GAA	p.G42E	LRRC2_uc003cpu.3_Intron	NM_003212	NP_003203	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	42					activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CCATCTCGGGGATACCTGGCC	0.517000													15	31					0	0	0.000308642	0	0
RAD54L2	23132	broad.mit.edu	37	3	51679118	51679118	+	Missense_Mutation	SNP	T	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:51679118T>G	uc011bdt.1	+	16	2654	c.2529T>G	c.(2527-2529)GAT>GAG	p.D843E	RAD54L2_uc003dbh.2_Missense_Mutation_p.D432E|RAD54L2_uc011bdu.1_Missense_Mutation_p.D537E|RAD54L2_uc003dbj.2_Missense_Mutation_p.D169E	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	843	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CTTGCCATGATGCCCAGGCAG	0.483000													15	48					0	0	0.000566183	0	0
ITIH1	3697	broad.mit.edu	37	3	52812490	52812491	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:52812490_52812491CC>TT	uc003dfs.2	+	3	297_298	c.273_274CC>TT	c.(271-276)ATCCCC>ATTTCC	p.P92S	ITIH1_uc010hmn.1_RNA	NM_002215	NP_002206	P19827	ITIH1_HUMAN	inter-alpha (globulin) inhibitor H1	92	VIT.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		ACCTGGAAATCCCCAAGACAGC	0.550000													16	36					0	0	6.4e-05	0	0
CACNA1D	776	broad.mit.edu	37	3	53694300	53694301	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:53694300_53694301CC>TT	uc003dgv.3	+	5	927_928	c.764_765CC>TT	c.(763-765)CCC>CTT	p.P255L	CACNA1D_uc003dgu.3_Missense_Mutation_p.P255L|CACNA1D_uc003dgy.3_Missense_Mutation_p.P255L	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	255	Cytoplasmic (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TCAGGAGTGCCCAGTAAGCACT	0.515000													11	21					0	0	6.4e-05	0	0
CCDC66	285331	broad.mit.edu	37	3	56605266	56605266	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:56605266C>T	uc003dhz.2	+	7	959	c.872C>T	c.(871-873)CCT>CTT	p.P291L	CCDC66_uc003dhy.2_5'UTR|CCDC66_uc003dhu.2_Missense_Mutation_p.P257L|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	291										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TGGAATGATCCTTGGAAAAAA	0.264000													26	51					0	0	0.000878237	0	0
FRMD4B	23150	broad.mit.edu	37	3	69245538	69245538	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:69245538G>A	uc003dnv.2	-	14	1392	c.1102C>T	c.(1102-1104)CCT>TCT	p.P368S	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_Missense_Mutation_p.P20S|FRMD4B_uc011bga.1_Missense_Mutation_p.P212S	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	368						cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		CTGGCTGAAGGAATTTTTGCC	0.363000													28	43					0	0	0.00127121	0	0
CADM2	253559	broad.mit.edu	37	3	86010738	86010738	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:86010738G>A	uc003dqj.2	+	7	1510	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	CADM2_uc003dqk.2_Missense_Mutation_p.R304Q|CADM2_uc003dql.2_Missense_Mutation_p.R297Q	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	295	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GGTACATATCGATGTGAAGCC	0.413000													19	52					0	0	0.000958276	0	0
MORC1	27136	broad.mit.edu	37	3	108677833	108677833	+	Missense_Mutation	SNP	A	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:108677833A>C	uc003dxl.2	-	28	3021	c.2934T>G	c.(2932-2934)AAT>AAG	p.N978K	MORC1_uc011bhn.1_Missense_Mutation_p.N957K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	978					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						aagtcttttcatttttttcta	0.184000													9	13					0	0	0.000274275	0	0
PLXND1	23129	broad.mit.edu	37	3	129302425	129302425	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:129302425G>A	uc003emx.2	-	8	2326	c.2226C>T	c.(2224-2226)GCC>GCT	p.A742A		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	742	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						GGTTTGGTGAGGCCTCGCACC	0.542000													4	17					0	0	0.000602214	0	0
EPHB1	2047	broad.mit.edu	37	3	134670598	134670598	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:134670598G>A	uc003eqt.2	+	3	729	c.509G>A	c.(508-510)CGG>CAG	p.R170Q	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Intron	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	170	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CCTCTTACTCGGAATGGTTTT	0.463000													56	107					0	0	0.000781405	0	0
STAG1	10274	broad.mit.edu	37	3	136196211	136196211	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:136196211C>T	uc003era.1	-	10	1238	c.946G>A	c.(946-948)GGA>AGA	p.G316R	STAG1_uc003erb.1_Missense_Mutation_p.G316R|STAG1_uc003erc.1_Missense_Mutation_p.G90R|STAG1_uc010hua.1_Missense_Mutation_p.G179R	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	316	SCD.				cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						ATCCATACTCCAATTTCTTCA	0.343000													21	40					0	0	0.00188189	0	0
IGSF10	285313	broad.mit.edu	37	3	151163919	151163919	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:151163919G>A	uc011bod.1	-	4	3850	c.3850C>T	c.(3850-3852)CCA>TCA	p.P1284S		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1284					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTCTTTGTTGGAAGACTTCCA	0.428000													31	54					0	0	0.000409698	0	0
WDR49	151790	broad.mit.edu	37	3	167245717	167245717	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:167245717G>A	uc003fev.1	-	11	1745	c.1439C>T	c.(1438-1440)TCC>TTC	p.S480F	WDR49_uc003feu.1_Missense_Mutation_p.S305F|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	480	WD 8.									large_intestine(1)|ovary(1)|skin(1)	3						CATCTCTAAGGAACTTATTCG	0.448000													19	34					0	0	0.00074312	0	0
WDR49	151790	broad.mit.edu	37	3	167246922	167246922	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:167246922G>A	uc003fev.1	-	10	1574	c.1268C>T	c.(1267-1269)TCG>TTG	p.S423L	WDR49_uc003feu.1_Missense_Mutation_p.S248L|WDR49_uc011bpd.1_Missense_Mutation_p.S487L|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	423	WD 7.									large_intestine(1)|ovary(1)|skin(1)	3						CATAATAATCGATCCAACTCC	0.363000													23	26					0	0	0.000586117	0	0
SLC7A14	57709	broad.mit.edu	37	3	170218993	170218993	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:170218993G>A	uc003fgz.2	-	3	762	c.446C>T	c.(445-447)GCC>GTC	p.A149V	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	149						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			ACTGGCTCCGGCCGCAGTGCC	0.557000													12	13					0	0	0.000978159	0	0
PEX5L	51555	broad.mit.edu	37	3	179605528	179605529	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:179605528_179605529GG>AA	uc003fki.1	-	4	372_373	c.242_243CC>TT	c.(241-243)TCC>TTT	p.S81F	PEX5L_uc011bqd.1_Missense_Mutation_p.S38F|PEX5L_uc011bqe.1_5'UTR|PEX5L_uc011bqf.1_Missense_Mutation_p.S38F|PEX5L_uc003fkj.1_Missense_Mutation_p.S46F|PEX5L_uc010hxd.1_Missense_Mutation_p.S79F|PEX5L_uc011bqg.1_Missense_Mutation_p.S57F|PEX5L_uc011bqh.1_Missense_Mutation_p.S22F	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	81					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			AGTCATCGATGGAGGGACTCAG	0.441000													46	117					0	0	6.4e-05	0	0
ATP11B	23200	broad.mit.edu	37	3	182631701	182631702	+	Missense_Mutation	DNP	CG	AT	AT	rs138385809		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:182631701_182631702CG>AT	uc003flb.2	+	29	3628_3629	c.3371_3372CG>AT	c.(3370-3372)CCG>CAT	p.P1124H	ATP11B_uc003flc.2_Missense_Mutation_p.P708H|ATP11B_uc010hxg.2_RNA|ATP11B_uc010hxh.1_3'UTR	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	1124	Cytoplasmic (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TGCTGTTTCCCGGAAGGAGAAG	0.450000													6	169					0	0	6.4e-05	0	0
MUC4	4585	broad.mit.edu	37	3	195481174	195481174	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:195481174C>T	uc011bto.1	-	20	15314	c.14854G>A	c.(14854-14856)GAG>AAG	p.E4952K	MUC4_uc010hzq.2_5'Flank|MUC4_uc003fuz.2_Missense_Mutation_p.E678K|MUC4_uc003fva.2_Missense_Mutation_p.E560K|MUC4_uc003fvb.2_Missense_Mutation_p.E596K|MUC4_uc003fvc.2_Intron|MUC4_uc003fvd.2_Intron|MUC4_uc003fve.2_Missense_Mutation_p.E596K|MUC4_uc010hzr.2_Intron|MUC4_uc011btf.1_Missense_Mutation_p.E560K|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Missense_Mutation_p.E644K|MUC4_uc011bti.1_Missense_Mutation_p.E644K|MUC4_uc011btj.1_Missense_Mutation_p.E821K|MUC4_uc011btk.1_Missense_Mutation_p.E560K|MUC4_uc011btl.1_Missense_Mutation_p.E589K|MUC4_uc011btm.1_Missense_Mutation_p.E769K|MUC4_uc011btn.1_Missense_Mutation_p.E560K|MUC4_uc003fvo.2_Missense_Mutation_p.E844K|MUC4_uc003fvp.2_Missense_Mutation_p.E793K	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1837					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AAGCACGGCTCCTCACAGGCA	0.692000													11	29					0	0	0.000978159	0	0
ZDHHC19	131540	broad.mit.edu	37	3	195936284	195936284	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr3:195936284C>T	uc003fwc.2	-	3	485	c.371G>A	c.(370-372)CGG>CAG	p.R124Q	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_RNA	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	124	DHHC-type.					integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		GTGGTAAGTCCGGGGCGGGCG	0.657000													3	2					0	0	6.4e-05	0	0
LETM1	3954	broad.mit.edu	37	4	1843299	1843299	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr4:1843299G>A	uc003gdv.2	-	3	666	c.369C>T	c.(367-369)TCC>TCT	p.S123S	LETM1_uc010icc.2_5'Flank|LETM1_uc011bvg.1_Silent_p.S123S	NM_012318	NP_036450	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane	123	Potential.|Mitochondrial intermembrane (Potential).				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			central_nervous_system(1)	1			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			AGGACTTGAGGGACTTCTCTA	0.612000													8	24					0	0	0.000157383	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095234	69095234	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr4:69095234C>T	uc003hdw.3	-	8	823	c.687G>A	c.(685-687)AAG>AAA	p.K229K		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	229	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AATTATTTTTCCTAGAGGACA	0.323000													7	19					0	0	8.12818e-05	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660429	77660429	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr4:77660429C>T	uc011cbx.1	+	5	2056	c.1103C>T	c.(1102-1104)TCC>TTC	p.S368F	SHROOM3_uc011cbz.1_Missense_Mutation_p.S192F|SHROOM3_uc003hkf.1_Missense_Mutation_p.S243F|SHROOM3_uc003hkg.2_Missense_Mutation_p.S146F	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	368					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TGCCCCAGTTCCTTGGAGACT	0.607000													14	23					0	0	0.000566183	0	0
MRPL1	65008	broad.mit.edu	37	4	78808385	78808386	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr4:78808385_78808386GG>AA	uc003hku.2	+	5	696_697	c.498_499GG>AA	c.(496-501)GAGGTC>GAAATC	p.V167I	MRPL1_uc010iji.1_Missense_Mutation_p.V90I	NM_020236	NP_064621	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1 precursor	167							RNA binding				0						ATGCATCAGAGGTCAAAATAGC	0.327000													7	18					0	0	6.4e-05	0	0
AFF1	4299	broad.mit.edu	37	4	88052237	88052237	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr4:88052237G>A	uc003hqj.3	+	16	3353	c.2946G>A	c.(2944-2946)ACG>ACA	p.T982T	AFF1_uc011ccz.1_Silent_p.T989T|AFF1_uc003hqk.3_Silent_p.T982T|AFF1_uc011cda.1_Silent_p.T620T	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	982						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCCTGCAGACGGACAGGGTTG	0.458000													25	29					0	0	0.001512	0	0
ACSL1	2180	broad.mit.edu	37	4	185698108	185698108	+	Silent	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr4:185698108A>G	uc003iww.2	-	6	801	c.507T>C	c.(505-507)GCT>GCC	p.A169A	ACSL1_uc011ckm.1_5'UTR|ACSL1_uc003iwt.1_Silent_p.A169A|ACSL1_uc003iwu.1_Silent_p.A169A|ACSL1_uc011ckn.1_Silent_p.A135A|ACSL1_uc003iwv.1_Silent_p.A169A	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	169	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCATCGAATAAGCAAAGCATC	0.393000													11	17					0	0	0.00185496	0	0
ZDHHC11	79844	broad.mit.edu	37	5	837498	837498	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:837498C>T	uc011cma.1	-	6	1266	c.882G>A	c.(880-882)ATG>ATA	p.M294I	ZDHHC11_uc003jbj.2_RNA|ZDHHC11_uc010itd.1_RNA	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	294						integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			CTCCTTTGTCCATTTGCACGT	0.483000													31	56					0	0	0.000409698	0	0
PAPD7	11044	broad.mit.edu	37	5	6748698	6748698	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:6748698C>T	uc003jdx.1	+	8	960	c.831C>T	c.(829-831)GCC>GCT	p.A277A	PAPD7_uc011cmn.1_Silent_p.A268A|PAPD7_uc010itl.1_Silent_p.A97A	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	277					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						ACAGAGACGCCGAAAGGTAAT	0.522000													33	82					0	0	0.000953801	0	0
PRLR	5618	broad.mit.edu	37	5	35084616	35084616	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:35084616C>T	uc003jjm.2	-	5	859	c.329G>A	c.(328-330)GGA>GAA	p.G110E	PRLR_uc003jjg.1_Missense_Mutation_p.G110E|PRLR_uc003jjh.1_Missense_Mutation_p.G110E|PRLR_uc003jji.1_Missense_Mutation_p.G39E|PRLR_uc003jjj.1_Missense_Mutation_p.G110E|PRLR_uc003jjk.1_Missense_Mutation_p.G39E|PRLR_uc003jjl.3_Intron|PRLR_uc010iuw.1_Missense_Mutation_p.G39E	NM_000949	NP_000940	P16471	PRLR_HUMAN	prolactin receptor precursor	110	Fibronectin type-III 1.|Extracellular (Potential).				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			ovary(2)|skin(1)	3	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GAAACTGCTTCCCATCTGGTT	0.468000													41	79					0	0	0.000781405	0	0
BDP1	55814	broad.mit.edu	37	5	70805913	70805913	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:70805913C>T	uc003kbp.1	+	17	3257	c.2994C>T	c.(2992-2994)GGC>GGT	p.G998G	BDP1_uc003kbn.1_Silent_p.G998G|BDP1_uc003kbo.2_Silent_p.G998G	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	998	4.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GGGAAAATGGCCCAGAGGAGG	0.463000													17	32					0	0	0.000958276	0	0
SPZ1	84654	broad.mit.edu	37	5	79616184	79616184	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:79616184C>T	uc003kgn.2	+	1	395	c.150C>T	c.(148-150)CTC>CTT	p.L50L	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		GGGGCTCTCTCCCTTTCCTAA	0.388000													36	73					0	0	0.00128727	0	0
SPZ1	84654	broad.mit.edu	37	5	79616605	79616605	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:79616605C>G	uc003kgn.2	+	1	816	c.571C>G	c.(571-573)CAG>GAG	p.Q191E	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	191	Basic motif (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAAGAAACAGCAGATGATAAT	0.353000													3	40					0	0	6.4e-05	0	0
GPR98	84059	broad.mit.edu	37	5	90074263	90074263	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:90074263C>T	uc003kju.2	+	63	12782	c.12686C>T	c.(12685-12687)CCC>CTC	p.P4229L	GPR98_uc003kjt.2_Missense_Mutation_p.P1935L|GPR98_uc003kjw.2_5'Flank	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4229	Extracellular (Potential).|Calx-beta 28.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GATGACATTCCCGAGGAAAAA	0.438000													4	10					0	0	0.000602214	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480554	140480554	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:140480554G>A	uc003lio.2	+	1	321	c.321G>A	c.(319-321)CAG>CAA	p.Q107Q	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	107	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TACATTTTCAGATATTACTGC	0.418000													32	40					0	0	0.00178596	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515317	140515317	+	Missense_Mutation	SNP	C	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:140515317C>G	uc003liq.2	+	1	518	c.301C>G	c.(301-303)CCC>GCC	p.P101A		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	101	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGACAGAACCCTGTATATT	0.433000													8	55					0	0	0.000274275	0	0
PCDHB12	56124	broad.mit.edu	37	5	140588661	140588661	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:140588661C>T	uc003liz.2	+	1	371	c.182C>T	c.(181-183)TCG>TTG	p.S61L	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	61	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCTGTCTTCGCGGGGGGCT	0.507000													28	69					0	0	0.000409698	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769433	140769433	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:140769433T>C	uc003lkc.1	+	1	1982	c.1982T>C	c.(1981-1983)GTC>GCC	p.V661A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc011dav.1_Missense_Mutation_p.V661A	NM_003736	NP_003727	Q9UN71	PCDGG_HUMAN	protocadherin gamma subfamily B, 4 isoform 1	661	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGCACCTGGTCTTCGCCGAC	0.657000													8	46					0	0	0.000274275	0	0
SPINK13	153218	broad.mit.edu	37	5	147653930	147653930	+	Missense_Mutation	SNP	T	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:147653930T>A	uc003lpc.2	+	3	153	c.91T>A	c.(91-93)TTC>ATC	p.F31I	uc003lpb.1_Intron|SPINK13_uc010jgt.2_RNA	NM_001040129	NP_001035218	Q1W4C9	ISK13_HUMAN	serine PI Kazal type 5-like 3 precursor	31						extracellular region	serine-type endopeptidase inhibitor activity				0						TAAACGTGACTTCACTAGGTG	0.338000													45	96					0	0	0.000781405	0	0
ERGIC1	57222	broad.mit.edu	37	5	172362241	172362241	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:172362241C>T	uc003mbw.3	+	9	887	c.693C>T	c.(691-693)TTC>TTT	p.F231F	ERGIC1_uc003mby.3_Silent_p.F139F|ERGIC1_uc011dfa.1_Silent_p.F176F|ERGIC1_uc003mca.3_RNA	NM_001031711	NP_001026881	Q969X5	ERGI1_HUMAN	endoplasmic reticulum-golgi intermediate	231	Lumenal (Potential).				ER to Golgi vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00344)|all_lung(126;0.00594)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CAATCTGGTTCCGCTACGACC	0.582000													9	28					0	0	0.000673444	0	0
FGFR4	2264	broad.mit.edu	37	5	176517623	176517623	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:176517623C>T	uc003mfl.2	+	3	491	c.324C>T	c.(322-324)ATC>ATT	p.I108I	FGFR4_uc003mfm.2_Silent_p.I108I|FGFR4_uc011dfu.1_Silent_p.I108I|FGFR4_uc011dfv.1_RNA|FGFR4_uc003mfn.1_Silent_p.I108I|FGFR4_uc011dfw.1_Silent_p.I108I|FGFR4_uc003mfo.2_Silent_p.I108I	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	108	Ig-like C2-type 1.|Extracellular (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GCTCCATGATCGTCCTGCAGA	0.597000										TSP Lung(9;0.080)			7	16					0	0	8.12818e-05	0	0
BTNL8	79908	broad.mit.edu	37	5	180377475	180377476	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:180377475_180377476CC>TT	uc003mmp.2	+	8	1668_1669	c.1434_1435CC>TT	c.(1432-1437)ATCCCA>ATTTCA	p.P479S	BTNL8_uc003mmq.2_3'UTR|BTNL8_uc011dhg.1_Missense_Mutation_p.P354S|BTNL8_uc010jll.2_3'UTR|BTNL8_uc010jlm.2_Missense_Mutation_p.P363S|BTNL8_uc011dhh.1_Missense_Mutation_p.P295S	NM_001040462	NP_001035552	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8 isoform 2 precursor	479	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|skin(1)	2	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCTGCAATCCCAGAGACAAG	0.510000													30	14					0	0	6.4e-05	0	0
GMDS	2762	broad.mit.edu	37	6	1961196	1961196	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:1961196G>A	uc003mtq.2	-	5	540	c.350C>T	c.(349-351)TCC>TTC	p.S117F		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	117					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		GAGGTCAAAGGAAATCTGGAA	0.468000													23	8					0	0	0.00188189	0	0
TRIM27	5987	broad.mit.edu	37	6	28872083	28872083	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:28872083C>A	uc003nlr.2	-	8	1665	c.1306G>T	c.(1306-1308)GTG>TTG	p.V436L	TRIM27_uc003nls.2_Intron|TRIM27_uc003nlt.1_3'UTR	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	436	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						AAAATCCCCACCCGCTGGAGC	0.532000			T	RET	papillary thyroid								97	27					7.41621e-29	5.9055e-28	0.000781405	1	0
BAT2	7916	broad.mit.edu	37	6	31604379	31604379	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:31604379C>T	uc003nvb.3	+	27	6177	c.5928C>T	c.(5926-5928)GCC>GCT	p.A1976A	BAT2_uc003nvc.3_Silent_p.A1976A	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1976	3 X 50 AA type C repeats.					cytoplasm|nucleus	protein binding				0						GGGCTCCTGCCCAGCAGGTAT	0.522000													22	111					0	0	0.00188189	0	0
CLIC1	1192	broad.mit.edu	37	6	31698697	31698698	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:31698697_31698698CC>AA	uc003nwr.2	-	6	911_912	c.647_648GG>TT	c.(646-648)CGG>CTT	p.R216L	DDAH2_uc003nwp.2_5'Flank|DDAH2_uc003nwq.2_5'Flank|CLIC1_uc003rje.2_Missense_Mutation_p.R216L	NM_001288	NP_001279	O00299	CLIC1_HUMAN	chloride intracellular channel 1	216	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			ovary(1)|central_nervous_system(1)	2						CGAATTCTTCCCGGGCGTAGGC	0.574000													13	547					0	0	6.4e-05	0	0
DOM3Z	1797	broad.mit.edu	37	6	31937781	31937781	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:31937781C>A	uc003nyo.1	-	6	1598	c.1064G>T	c.(1063-1065)TGG>TTG	p.W355L	DOM3Z_uc003nyp.1_Missense_Mutation_p.W355L|DOM3Z_uc003nyq.1_Missense_Mutation_p.W96L|DOM3Z_uc003nyr.1_Missense_Mutation_p.W355L|DOM3Z_uc003nys.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	355							identical protein binding|metal ion binding|nucleotide binding				0						GCCAGGCTCCCAAGAGAAGAG	0.587000													9	501					0.000274275	0.00213142	0.000274275	1	0
DOM3Z	1797	broad.mit.edu	37	6	31938769	31938770	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:31938769_31938770CG>AT	uc003nyo.1	-	2	1045_1046	c.511_512CG>AT	c.(511-513)CGG>ATG	p.R171M	DOM3Z_uc003nyp.1_Missense_Mutation_p.R171M|DOM3Z_uc003nyq.1_Translation_Start_Site|DOM3Z_uc003nyr.1_Missense_Mutation_p.R171M|DOM3Z_uc003nys.1_Missense_Mutation_p.R171M|DOM3Z_uc010jtl.1_3'UTR|STK19_uc003nyt.2_5'Flank|STK19_uc011dow.1_5'Flank|STK19_uc011dox.1_5'Flank|STK19_uc003nyv.2_5'Flank|STK19_uc003nyw.2_5'Flank|STK19_uc010jtn.1_5'Flank	NM_005510	NP_005501	O77932	DOM3Z_HUMAN	DOM-3 homolog Z	171							identical protein binding|metal ion binding|nucleotide binding				0						CCTCTGGGCCCGAGCGTTCGGT	0.589000													18	795					0	0	6.4e-05	0	0
FKBPL	63943	broad.mit.edu	37	6	32097439	32097440	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:32097439_32097440CG>AT	uc003nzr.2	-	2	388_389	c.118_119CG>AT	c.(118-120)CGA>ATA	p.R40I	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	40					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						AGGAGGGTCTCGGGGCTGCTGC	0.485000													9	711					0	0	6.4e-05	0	0
PPT2	9374	broad.mit.edu	37	6	32122815	32122816	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:32122815_32122816CG>AT	uc003nzx.2	+	3	760_761	c.192_193CG>AT	c.(190-195)CCCGGG>CCATGG	p.G65W	PRRT1_uc003nzu.2_5'Flank|uc003nzv.3_5'Flank|PPT2_uc003nzw.2_Missense_Mutation_p.G71W|PPT2_uc011dpi.1_Intron|PPT2_uc003nzy.1_RNA|PPT2_uc003nzz.2_Missense_Mutation_p.G65W|PPT2_uc003oaa.2_Missense_Mutation_p.G65W|PPT2_uc010jtu.1_Missense_Mutation_p.G65W	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a	65					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						AGACACACCCCGGGACTGTGGT	0.619000													9	270					0	0	6.4e-05	0	0
NOTCH4	4855	broad.mit.edu	37	6	32168976	32168976	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:32168976C>T	uc003obb.2	-	22	4196	c.4057G>A	c.(4057-4059)GGA>AGA	p.G1353R	NOTCH4_uc003oba.2_Missense_Mutation_p.G16R|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1353	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TCCCGAGTTCCTCCTAGCTTT	0.602000													22	316					0	0	0.000295444	0	0
BRPF3	27154	broad.mit.edu	37	6	36169209	36169209	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:36169209C>T	uc003olv.3	+	2	1334	c.1110C>T	c.(1108-1110)CTC>CTT	p.L370L	BRPF3_uc010jwb.2_Silent_p.L370L|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.L370L	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	370					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						AAACCAGCCTCAATGGCACCA	0.572000													33	10					0	0	0.000692331	0	0
DNAH8	1769	broad.mit.edu	37	6	38834641	38834641	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:38834641C>T	uc003ooe.1	+	45	6631	c.6031C>T	c.(6031-6033)CTT>TTT	p.L2011F		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGAAGAGCAACTTACTAAACA	0.323000													37	7					0	0	0.000814825	0	0
C6orf153	88745	broad.mit.edu	37	6	42996894	42996894	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:42996894G>A	uc003otp.1	+	7	716	c.708G>A	c.(706-708)GAG>GAA	p.E236E		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	236					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			AGAAATTGGAGAACTTCTTGA	0.478000													181	50					0	0	0.000781405	0	0
CUL9	23113	broad.mit.edu	37	6	43181465	43181465	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:43181465C>T	uc003ouk.2	+	29	5578	c.5503C>T	c.(5503-5505)CAT>TAT	p.H1835Y	CUL9_uc003oul.2_Intron|CUL9_uc010jyk.2_Missense_Mutation_p.H987Y|CUL9_uc003oun.2_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	1835				Missing (in Ref. 3; CAH18696).	ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						GCTGCGGCTTCATGAGCCTGG	0.612000													13	90					0	0	0.000308642	0	0
DST	667	broad.mit.edu	37	6	56391321	56391321	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:56391321G>A	uc003pdf.2	-	63	11638	c.11610C>T	c.(11608-11610)TCC>TCT	p.S3870S	DST_uc003pcz.3_Silent_p.S3692S|DST_uc011dxj.1_Silent_p.S3721S|DST_uc011dxk.1_Silent_p.S3732S|DST_uc003pcy.3_Silent_p.S3366S	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5778					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTTCATTAAGGGAGTCCAGTA	0.418000													31	243					0	0	0.00111076	0	0
FAM135A	57579	broad.mit.edu	37	6	71235824	71235824	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:71235824C>T	uc003pfj.2	+	13	3170	c.3037C>T	c.(3037-3039)CCT>TCT	p.P1013S	FAM135A_uc003pfi.2_Missense_Mutation_p.P817S|FAM135A_uc003pfh.2_Missense_Mutation_p.P800S|FAM135A_uc003pfl.2_Missense_Mutation_p.P680S|FAM135A_uc003pfn.2_Missense_Mutation_p.P219S|FAM135A_uc003pfo.1_Missense_Mutation_p.P384S|FAM135A_uc010kan.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	1013										central_nervous_system(1)	1						TTCAGAAATCCCTACAGTTGA	0.338000													59	22					0	0	0.000781405	0	0
DDX43	55510	broad.mit.edu	37	6	74111671	74111671	+	Missense_Mutation	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:74111671A>G	uc003pgw.2	+	4	870	c.526A>G	c.(526-528)ATT>GTT	p.I176V	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	176						intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TTGGGATCAAATTAGAGAGGA	0.373000													95	39					0	0	0.000781405	0	0
CD109	135228	broad.mit.edu	37	6	74472164	74472164	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:74472164C>T	uc003php.2	+	8	1241	c.816C>T	c.(814-816)TCC>TCT	p.S272S	CD109_uc010kaz.2_Silent_p.S272S|CD109_uc003phq.2_Silent_p.S272S|CD109_uc010kba.2_Silent_p.S195S	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	272						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TACCTTTATCCTTTTGGGGAA	0.289000													5	70					0	0	0.00116845	0	0
GPR6	2830	broad.mit.edu	37	6	110300536	110300536	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:110300536C>T	uc011eaw.1	+	2	401	c.221C>T	c.(220-222)CCG>CTG	p.P74L	GPR6_uc011eav.1_Missense_Mutation_p.P89L|GPR6_uc003ptu.2_Missense_Mutation_p.P74L	NM_005284	NP_005275	P46095	GPR6_HUMAN	G protein-coupled receptor 6	74	Extracellular (Potential).					integral to plasma membrane					0		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		GCGGTGAATCCGTGGGACGTG	0.692000													11	31					0	0	0.00185496	0	0
RFX6	222546	broad.mit.edu	37	6	117203570	117203570	+	Missense_Mutation	SNP	T	C	C			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr6:117203570T>C	uc003pxm.2	+	4	608	c.545T>C	c.(544-546)CTT>CCT	p.L182P		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	182	RFX-type winged-helix.				glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ACAAGGCGGCTTGGAACAAGA	0.393000													5	7					0	0	8.12818e-05	0	0
ABCB5	340273	broad.mit.edu	37	7	20721180	20721180	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:20721180G>A	uc003suw.3	+	6	971	c.425G>A	c.(424-426)CGA>CAA	p.R142Q	ABCB5_uc010kuh.2_Missense_Mutation_p.R587Q	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	142	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TCTACTATTCGAAGTGCAGAT	0.403000													9	24					0	0	0.000442599	0	0
HGF	3082	broad.mit.edu	37	7	81381436	81381436	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:81381436C>T	uc003uhl.2	-	5	790	c.625G>A	c.(625-627)GTT>ATT	p.V209I	HGF_uc003uhm.2_Missense_Mutation_p.V204I|HGF_uc003uhn.1_Missense_Mutation_p.V209I|HGF_uc003uho.1_Missense_Mutation_p.V204I|HGF_uc003uhp.2_Missense_Mutation_p.G209S	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	209					epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GTTTATTTACCTTCTGAACAC	0.443000													6	36					0	0	0.000157383	0	0
HGF	3082	broad.mit.edu	37	7	81388076	81388076	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:81388076G>A	uc003uhl.2	-	3	464	c.299C>T	c.(298-300)CCC>CTC	p.P100L	HGF_uc003uhm.2_Missense_Mutation_p.P100L|HGF_uc003uhn.1_Missense_Mutation_p.P100L|HGF_uc003uho.1_Missense_Mutation_p.P100L|HGF_uc003uhp.2_Missense_Mutation_p.P100L	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	100	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						GCTATTGAAGGGGAACCAGAG	0.318000													40	61					0	0	0.000509022	0	0
MGC26647	219557	broad.mit.edu	37	7	88423705	88423705	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:88423705G>A	uc003ujv.2	-	2	734	c.552C>T	c.(550-552)TAC>TAT	p.Y184Y	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	184											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			TCTGGCAAAGGTAGAGTGACA	0.423000													32	85					0	0	0.000339439	0	0
TRRAP	8295	broad.mit.edu	37	7	98581893	98581893	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:98581893C>T	uc003upp.2	+	60	9421	c.9212C>T	c.(9211-9213)CCT>CTT	p.P3071L	TRRAP_uc011kis.1_Missense_Mutation_p.P3042L|TRRAP_uc003upr.2_Missense_Mutation_p.P2759L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3071	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCAACTGTTCCTATCGTGGAT	0.478000													28	63					0	0	0.00127121	0	0
LRCH4	4034	broad.mit.edu	37	7	100179429	100179429	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:100179429C>T	uc003uvj.2	-	4	622	c.569G>A	c.(568-570)CGG>CAG	p.R190Q	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	190	LRR 7.				nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTGGTTCCTCCGGACATTGAG	0.488000													11	33					0	0	0.00185496	0	0
Unknown	0	broad.mit.edu	37	7	100551777	100551777	+	RNA	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:100551777C>T	uc003uxk.1	+	1		c.1028C>T			uc003uxl.1_Silent_p.I76I					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		TGAGCACGATCGTGTCAACAT	0.473000													90	286					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	7	100551902	100551903	+	RNA	DNP	GG	TT	TT			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:100551902_100551903GG>TT	uc003uxk.1	+	1		c.1153_1154GG>TT			uc003uxl.1_Missense_Mutation_p.R118I					Homo sapiens MUC3B mRNA for intestinal mucin, partial cds.																		TCTTTCACTAGGGGAAGTACGT	0.436000													10	483					0	0	6.4e-05	0	0
LAMB4	22798	broad.mit.edu	37	7	107708485	107708485	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:107708485C>T	uc010ljo.1	-	19	2506	c.2422G>A	c.(2422-2424)GAT>AAT	p.D808N	LAMB4_uc003vey.2_Missense_Mutation_p.D808N	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	808	Laminin EGF-like 6.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGCCCCAAATCATAGCTTCCA	0.552000													49	154					0	0	0.000781405	0	0
CFTR	1080	broad.mit.edu	37	7	117227832	117227832	+	Missense_Mutation	SNP	G	A	A	rs113993959	byFrequency	TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:117227832G>A	uc003vjd.2	+	12	1756	c.1624G>A	c.(1624-1626)GGA>AGA	p.G542R	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	542	Cytoplasmic (Potential).|ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TATAGTTCTTGGAGAAGGTGG	0.358000									Cystic_Fibrosis				17	23					0	0	0.000958276	0	0
C7orf58	79974	broad.mit.edu	37	7	120780953	120780953	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:120780953C>T	uc003vjq.3	+	15	2219	c.1772C>T	c.(1771-1773)CCA>CTA	p.P591L	C7orf58_uc003vjs.3_Missense_Mutation_p.P591L|C7orf58_uc003vjt.3_Missense_Mutation_p.P371L	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	591						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GACTTTCATCCAAAGATCAAA	0.378000													12	35					0	0	0.000978159	0	0
C7orf58	79974	broad.mit.edu	37	7	120935554	120935554	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:120935554C>T	uc003vjq.3	+	23	3376	c.2929C>T	c.(2929-2931)CAT>TAT	p.H977Y		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	977						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ATCAAGAAATCATATCATGGG	0.328000													11	29					0	0	0.000673444	0	0
EPHA1	2041	broad.mit.edu	37	7	143092274	143092274	+	Silent	SNP	T	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:143092274T>A	uc003wcz.2	-	13	2172	c.2085A>T	c.(2083-2085)CGA>CGT	p.R695R		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	695	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				TGATCGGCTTTCCTGAGACAC	0.557000													38	45					0	0	0.00111076	0	0
PTPRN2	5799	broad.mit.edu	37	7	157931072	157931072	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr7:157931072C>T	uc003wno.2	-	7	1167	c.1046G>A	c.(1045-1047)CGA>CAA	p.R349Q	PTPRN2_uc003wnp.2_Missense_Mutation_p.R332Q|PTPRN2_uc003wnq.2_Missense_Mutation_p.R349Q|PTPRN2_uc003wnr.2_Missense_Mutation_p.R311Q|PTPRN2_uc011kwa.1_Missense_Mutation_p.R372Q	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	349	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGGGCTGCCTCGAGCTACTCC	0.672000													11	33					0	0	0.000673444	0	0
CSMD1	64478	broad.mit.edu	37	8	3000081	3000081	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:3000081G>A	uc011kwk.1	-	41	6540	c.6150C>T	c.(6148-6150)CTC>CTT	p.L2050L	CSMD1_uc011kwj.1_Silent_p.L1442L|CSMD1_uc010lrg.2_Silent_p.L118L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2050	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGGCCGCGGGGAGATCCGTGC	0.463000													34	46					0	0	0.00058488	0	0
XPO7	23039	broad.mit.edu	37	8	21861515	21861515	+	Silent	SNP	A	G	G			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:21861515A>G	uc003xaa.3	+	27	3246	c.3144A>G	c.(3142-3144)CGA>CGG	p.R1048R	XPO7_uc010lti.2_Silent_p.R1057R|XPO7_uc010ltk.2_Silent_p.R1049R	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	1048					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		GCATCGAGCGAAATCTTCTTA	0.438000													7	18					0	0	0.000157383	0	0
EPB49	2039	broad.mit.edu	37	8	21938900	21938900	+	Missense_Mutation	SNP	A	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:21938900A>T	uc011kyt.1	+	15	1373	c.1144A>T	c.(1144-1146)ATG>TTG	p.M382L	EPB49_uc010ltl.2_Missense_Mutation_p.M360L|EPB49_uc010ltn.2_Missense_Mutation_p.M335L|EPB49_uc011kyu.1_Missense_Mutation_p.M382L|EPB49_uc011kyv.1_Missense_Mutation_p.M382L|EPB49_uc010ltq.2_Missense_Mutation_p.M360L	NM_001114136	NP_001107608	Q08495	DEMA_HUMAN	erythrocyte membrane protein band 4.9 isoform 1	382	HP.				actin filament bundle assembly|actin filament capping	actin cytoskeleton|nucleus	actin binding			central_nervous_system(1)	1				Colorectal(74;9.05e-05)|READ - Rectum adenocarcinoma(5;0.0276)|COAD - Colon adenocarcinoma(73;0.0631)		GGTATTTGCCATGTCCCCTGA	0.602000													29	41					0	0	0.000491102	0	0
ANK1	286	broad.mit.edu	37	8	41543692	41543692	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:41543692G>A	uc003xok.2	-	36	4452	c.4368C>T	c.(4366-4368)ATC>ATT	p.I1456I	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Silent_p.I772I|ANK1_uc003xoi.2_Silent_p.I1456I|ANK1_uc003xoj.2_Silent_p.I1456I|ANK1_uc003xol.2_Silent_p.I1456I|ANK1_uc003xom.2_Silent_p.I1497I	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1456	55 kDa regulatory domain.|Death.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGCCTTCACGGATGACCCAGA	0.527000													20	22					0	0	0.000295444	0	0
HNF4G	3174	broad.mit.edu	37	8	76476236	76476236	+	Missense_Mutation	SNP	C	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:76476236C>A	uc003yaq.2	+	11	1402	c.1132C>A	c.(1132-1134)CCA>ACA	p.P378T	HNF4G_uc003yar.2_Missense_Mutation_p.P415T	NM_004133	NP_004124	Q14541	HNF4G_HUMAN	hepatocyte nuclear factor 4, gamma	378					endocrine pancreas development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1	Breast(64;0.0448)		BRCA - Breast invasive adenocarcinoma(89;0.161)			ACTCCCTTCCCCACCACAAGG	0.448000													6	92					0.00116845	0.00902572	0.00116845	1	0
STMN2	11075	broad.mit.edu	37	8	80553689	80553689	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:80553689C>T	uc003ybj.2	+	3	243	c.192C>T	c.(190-192)ATC>ATT	p.I64I	STMN2_uc010lzp.2_RNA|STMN2_uc011lfn.1_Silent_p.I64I	NM_007029	NP_008960	Q93045	STMN2_HUMAN	superiorcervical ganglia, neural specific 10	64	Regulatory/phosphorylation domain (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			CATCTCCTATCTCAGAAGCCC	0.458000													15	32					0	0	0.000308642	0	0
STMN2	11075	broad.mit.edu	37	8	80553691	80553691	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:80553691C>T	uc003ybj.2	+	3	245	c.194C>T	c.(193-195)TCA>TTA	p.S65L	STMN2_uc010lzp.2_RNA|STMN2_uc011lfn.1_Missense_Mutation_p.S65L	NM_007029	NP_008960	Q93045	STMN2_HUMAN	superiorcervical ganglia, neural specific 10	65	Regulatory/phosphorylation domain (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			TCTCCTATCTCAGAAGCCCCA	0.458000													17	31					0	0	0.000566183	0	0
KCNV1	27012	broad.mit.edu	37	8	110980770	110980770	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:110980770G>A	uc003ynr.3	-	3	1392	c.1050C>T	c.(1048-1050)CTC>CTT	p.L350L	KCNV1_uc010mcw.2_Silent_p.L350L	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	350	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATAGAAATAGGAGCAGTAGGC	0.433000													12	24					0	0	0.00185496	0	0
FER1L6	654463	broad.mit.edu	37	8	125076649	125076649	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:125076649C>T	uc003yqw.2	+	26	3596	c.3390C>T	c.(3388-3390)CCC>CCT	p.P1130P	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1130	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CCCAGGATCCCCCAGCAGATC	0.572000													41	75					0	0	0.000781405	0	0
GLI4	2738	broad.mit.edu	37	8	144351607	144351607	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:144351607C>T	uc003yxx.2	+	2	126	c.41C>T	c.(40-42)CCG>CTG	p.P14L	ZFP41_uc003yxv.2_Intron	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	14						nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			CCTTCTGTCCCGTCCCCTGTC	0.592000													22	46					0	0	0.000295444	0	0
GRINA	2907	broad.mit.edu	37	8	145065397	145065397	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr8:145065397C>T	uc003zan.1	+	2	172	c.6C>T	c.(4-6)TCC>TCT	p.S2S	GRINA_uc003zao.1_Silent_p.S2S|GRINA_uc003zap.1_Silent_p.S2S	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	2						integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGCCATGTCCCATGAAAAGA	0.617000													15	34					0	0	0.00074312	0	0
Unknown	0	broad.mit.edu	37	9	69067873	69067873	+	RNA	SNP	A	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr9:69067873A>T	uc004afe.1	+	3		c.689A>T			uc010mnq.1_RNA					Homo sapiens cDNA, FLJ18209.																		aagaagaaaaagagcaaagat	0.214000													7	5					0	0	0.000157383	0	0
Unknown	0	broad.mit.edu	37	9	69067929	69067929	+	Splice_Site	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr9:69067929G>A	uc004afe.1	+	3		c.744_splice	c.e3+1		uc010mnq.1_Splice_Site					Homo sapiens cDNA, FLJ18209.																		TGATATGTTGGTGAGTCAGTT	0.209000													14	8					0	0	0.000958276	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71549904	71549904	+	Missense_Mutation	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr9:71549904G>A	uc004agu.2	+	13	1605	c.1300G>A	c.(1300-1302)GAT>AAT	p.D434N	PIP5K1B_uc011lrq.1_Missense_Mutation_p.D434N|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	434						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		GGAATGGAAGGATGAGAAGCG	0.428000													5	19					0	0	0.000602214	0	0
TRAF1	7185	broad.mit.edu	37	9	123673690	123673690	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr9:123673690G>A	uc004bku.1	-	6	1379	c.807C>T	c.(805-807)TTC>TTT	p.F269F	TRAF1_uc011lyg.1_Silent_p.F147F|TRAF1_uc010mvl.1_Silent_p.F269F	NM_005658	NP_005649	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	269	MATH.				apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			skin(2)|ovary(1)	3						TCTTCCACAGGAAAGTGCCAT	0.622000													8	6					0	0	0.000157383	0	0
COL5A1	1289	broad.mit.edu	37	9	137717717	137717717	+	Silent	SNP	G	A	A	rs148006741		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr9:137717717G>A	uc004cfe.2	+	63	5416	c.5034G>A	c.(5032-5034)TCG>TCA	p.S1678S	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1678	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCGGGGGGTCGACATGCGTCT	0.592000													7	20					0	0	0.000274275	0	0
GYG2	8908	broad.mit.edu	37	X	2772069	2772069	+	Silent	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chrX:2772069C>T	uc004cqs.1	+	5	573	c.291C>T	c.(289-291)ATC>ATT	p.I97I	GYG2_uc004cqt.1_Silent_p.I66I|GYG2_uc004cqu.1_Silent_p.I66I|GYG2_uc004cqv.1_5'UTR|GYG2_uc004cqw.1_Silent_p.I57I|GYG2_uc004cqx.1_Silent_p.I66I|GYG2_uc010ndc.1_5'Flank	NM_003918	NP_003909	O15488	GLYG2_HUMAN	glycogenin 2 isoform b	97					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|soluble fraction	glycogenin glucosyltransferase activity			ovary(1)|kidney(1)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGAATCTAATCGATAGTGCCG	0.502000													18	15					0	0	0.00152264	0	0
ZMYM3	9203	broad.mit.edu	37	X	70469396	70469396	+	Missense_Mutation	SNP	G	A	A	rs138633030		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chrX:70469396G>A	uc004dzh.1	-	7	1472	c.1385C>T	c.(1384-1386)ACC>ATC	p.T462I	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.T462I|ZMYM3_uc004dzj.1_Missense_Mutation_p.T462I|ZMYM3_uc011mpu.1_Missense_Mutation_p.T193I|ZMYM3_uc004dzk.3_Missense_Mutation_p.T462I|ZMYM3_uc004dzl.3_Missense_Mutation_p.T462I|ZMYM3_uc004dzm.3_Missense_Mutation_p.T462I	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	462	MYM-type 3.				multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					AGGACTCCCGGTCTTGGTGTA	0.577000													4	4					0	0	0.00024832	0	0
BTK	695	broad.mit.edu	37	X	100615596	100615596	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chrX:100615596C>T	uc004ehg.2	-	8	929	c.736G>A	c.(736-738)GAA>AAA	p.E246K	BTK_uc004ehf.2_5'Flank|BTK_uc010nnh.2_5'Flank|BTK_uc010nni.2_5'Flank|BTK_uc004ehe.2_5'Flank|BTK_uc010nnj.2_5'Flank|BTK_uc010nnk.2_5'Flank|BTK_uc010nnl.2_5'Flank|BTK_uc010nnm.2_5'Flank|BTK_uc010nnn.2_Missense_Mutation_p.E246K|BTK_uc010nno.2_Missense_Mutation_p.E280K|BTK_uc004ehh.1_5'Flank|BTK_uc004ehi.2_Missense_Mutation_p.E246K	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	246	SH3.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						AAGTTGCTTTCCTCCAAGATA	0.473000									Agammaglobulinemia_X-linked				34	23					0	0	0.00058488	0	0
COL4A5	1287	broad.mit.edu	37	X	107783035	107783035	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chrX:107783035G>A	uc004enz.1	+	2	343	c.141G>A	c.(139-141)AAG>AAA	p.K47K	COL4A5_uc011mso.1_Silent_p.K47K	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	47	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						AAGGGGAAAAGGTGAGGTCTT	0.333000									Alport_syndrome_with_Diffuse_Leiomyomatosis				23	27					0	0	0.000878237	0	0
KLHL13	90293	broad.mit.edu	37	X	117043528	117043528	+	Missense_Mutation	SNP	C	T	T			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chrX:117043528C>T	uc004eql.2	-	5	1164	c.1102G>A	c.(1102-1104)GAG>AAG	p.E368K	KLHL13_uc004eqk.2_Missense_Mutation_p.E317K|KLHL13_uc011mtn.1_Missense_Mutation_p.E208K|KLHL13_uc011mto.1_Missense_Mutation_p.E362K|KLHL13_uc011mtp.1_Missense_Mutation_p.E370K|KLHL13_uc004eqm.2_Missense_Mutation_p.E317K|KLHL13_uc011mtq.1_Missense_Mutation_p.E352K	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	368	Kelch 1.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GATTTCCACTCATGGGCCTTT	0.493000													19	19					0	0	0.00188189	0	0
GLUD2	2747	broad.mit.edu	37	X	120182576	120182576	+	Silent	SNP	G	A	A			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chrX:120182576G>A	uc004eto.2	+	1	1115	c.1038G>A	c.(1036-1038)AAG>AAA	p.K346K		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	346					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TTGACCCAAAGGAACTGGAAG	0.448000													20	65					0	0	0.00188189	0	0
RUSC1	23623	broad.mit.edu	37	1	155295247	155295247	+	Frame_Shift_Del	DEL	C	-	-			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr1:155295247delC	uc001fkj.2	+	5	1903	c.1674delC	c.(1672-1674)AGCfs	p.S558fs	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Frame_Shift_Del_p.S558fs|RUSC1_uc009wqn.1_Intron|RUSC1_uc009wqo.1_Frame_Shift_Del_p.S89fs|RUSC1_uc001fkl.2_Frame_Shift_Del_p.S148fs|RUSC1_uc001fkp.2_Frame_Shift_Del_p.S89fs|RUSC1_uc001fkq.2_Frame_Shift_Del_p.S89fs|RUSC1_uc010pgb.1_Frame_Shift_Del_p.S56fs|RUSC1_uc009wqp.1_Frame_Shift_Del_p.S83fs|RUSC1_uc001fkn.2_5'UTR|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Frame_Shift_Del_p.S89fs|RUSC1_uc001fks.2_5'Flank	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	558	RUN.					cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GCAGGAGCAGCCCCTGGAGCG	0.721											OREG0013860	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
FMN1	342184	broad.mit.edu	37	15	33359256	33359256	+	Frame_Shift_Del	DEL	A	-	-	rs34563484		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr15:33359256delA	uc001zhf.3	-	1	830	c.830delT	c.(829-831)TTCfs	p.F277fs	FMN1_uc001zhg.2_Frame_Shift_Del_p.F277fs	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		AAGCCCACTGAAAAAAGCTGG	0.468													58	44	---	---	---	---					
SNRNP70	6625	broad.mit.edu	37	19	49611383	49611384	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr19:49611383_49611384delGG	uc002pmk.2	+	10	1436_1437	c.997_998delGG	c.(997-999)GGGfs	p.G333fs	SNRNP70_uc002pmh.1_RNA|SNRNP70_uc002pmi.1_Frame_Shift_Del_p.G324fs|SNRNP70_uc002pml.2_Frame_Shift_Del_p.Q119fs|SNRNP70_uc002pmm.2_RNA	NM_003089	NP_003080	P08621	RU17_HUMAN	U1 small nuclear ribonucleoprotein 70 kDa	333					nuclear mRNA splicing, via spliceosome|regulation of RNA splicing	nucleoplasm|spliceosomal complex	nucleotide binding|protein binding|RNA binding				0						TGGGCCTCCAGGGGAGCTCGGG	0.515													2	4	---	---	---	---					
MSH3	4437	broad.mit.edu	37	5	79950742	79950750	+	In_Frame_Del	DEL	CCCCCAGCT	-	-	rs3045983		TCGA-D9-A149-06A-11D-A196-08	TCGA-D9-A149-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	9fa448bd-3234-4b4d-918f-0c157c847512	334de3b8-4b3a-4e80-8d9f-4d81b1143139	g.chr5:79950742_79950750delCCCCCAGCT	uc003kgz.2	+	1	449_457	c.196_204delCCCCCAGCT	c.(196-204)CCCCCAGCTdel	p.PPA66del	DHFR_uc011ctl.1_5'Flank|DHFR_uc011ctm.1_5'Flank|DHFR_uc010jap.1_5'Flank|DHFR_uc003kgx.1_In_Frame_Del_p.11_14GAGG>G|DHFR_uc003kgy.1_5'UTR	NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	66_68					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		gCCCCCAGCGCCCCCAGCTCCCGCCTTCC	0.598								MMR					3	3	---	---	---	---					
