Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	979020	979020	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:979020C>T	uc001ack.1	+	9	1756	c.1706C>T	c.(1705-1707)TCC>TTC	p.S569F		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	569	Kazal-like 6.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GTGTGTGGCTCCGACGGGCAC	0.682000													17	114					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1558797	1558797	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:1558797C>T	uc001agg.2	+	3	266	c.139C>T	c.(139-141)CCC>TCC	p.P47S	MIB2_uc001agh.2_Intron|MIB2_uc001agi.2_Missense_Mutation_p.P47S|MIB2_uc001agj.2_5'UTR|MIB2_uc001agk.2_Missense_Mutation_p.P47S|MIB2_uc001agl.1_Missense_Mutation_p.P3S|MIB2_uc001agm.2_Intron|MIB2_uc010nyq.1_Missense_Mutation_p.P3S|MIB2_uc009vkh.2_5'Flank|MIB2_uc001agn.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	47					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACCATGGACCCCTCTGCCCA	0.706000													3	16					0	0	1	0	0
TMEM52	339456	broad.mit.edu	37	1	1849476	1849476	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:1849476C>T	uc001aij.2	-	5	511	c.475G>A	c.(475-477)GAA>AAA	p.E159K	TMEM52_uc001aii.2_Missense_Mutation_p.E144K	NM_178545	NP_848640	Q8NDY8	TMM52_HUMAN	transmembrane protein 52 precursor	159						integral to membrane					0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TTGACAGCTTCATCGTAGGAG	0.642000													25	162					0	0	1	0	0
PLCH2	9651	broad.mit.edu	37	1	2430618	2430619	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:2430618_2430619GG>AA	uc001aji.1	+	19	2804_2805	c.2530_2531GG>AA	c.(2530-2532)GGG>AAG	p.G844K	PLCH2_uc010nyz.1_Missense_Mutation_p.G632K|PLCH2_uc009vle.1_Missense_Mutation_p.G596K|PLCH2_uc001ajj.1_Missense_Mutation_p.G632K|PLCH2_uc001ajk.1_Missense_Mutation_p.G632K|PLCH2_uc001ajl.1_5'UTR	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	844	C2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CGATCCCATCGGGCGTGACTTC	0.658000													7	49					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2537756	2537756	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:2537756G>A	uc001ajy.2	-	8	895	c.681C>T	c.(679-681)TTC>TTT	p.F227F	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	227	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CGCGCCTGTTGAACTGTGAGT	0.662000													11	45					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3319387	3319387	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:3319387G>A	uc001akf.2	+	6	789	c.709G>A	c.(709-711)GAA>AAA	p.E237K	PRDM16_uc001akc.2_Missense_Mutation_p.E237K|PRDM16_uc001akd.2_Missense_Mutation_p.E237K|PRDM16_uc001ake.2_Missense_Mutation_p.E237K|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	237	C2H2-type 1; atypical.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CGAGTGTGACGAACTCTTCCA	0.617000			T	EVI1	MDS|AML								13	70					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3329112	3329112	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:3329112C>T	uc001akf.2	+	9	2431	c.2351C>T	c.(2350-2352)CCC>CTC	p.P784L	PRDM16_uc001akc.2_Missense_Mutation_p.P784L|PRDM16_uc001akd.2_Missense_Mutation_p.P784L|PRDM16_uc001ake.2_Missense_Mutation_p.P784L|PRDM16_uc009vlh.2_Missense_Mutation_p.P485L	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	784	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GACGTGAAGCCCATCCTGCCC	0.697000			T	EVI1	MDS|AML								6	52					0	0	1	0	0
C1orf174	339448	broad.mit.edu	37	1	3807488	3807488	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:3807488G>A	uc001alf.2	-	3	370	c.263C>T	c.(262-264)CCT>CTT	p.P88L	C1orf174_uc009vls.2_RNA	NM_207356	NP_997239	Q8IYL3	CA174_HUMAN	hypothetical protein LOC339448	88											0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;5.09e-25)|all_epithelial(116;9.35e-17)|all_lung(118;1.09e-06)|Lung NSC(185;0.000139)|all_neural(13;0.00287)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0219)|all_hematologic(16;0.027)|Colorectal(325;0.0276)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;1.55e-39)|OV - Ovarian serous cystadenocarcinoma(86;5.99e-23)|GBM - Glioblastoma multiforme(42;2.22e-17)|Colorectal(212;1.08e-05)|COAD - Colon adenocarcinoma(227;5.49e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000365)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.19)		AGGGGTCTCAGGTGTCACTTT	0.498000													11	54					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6184141	6184141	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:6184141C>T	uc001amb.1	-	31	4666	c.4566G>A	c.(4564-4566)GGG>GGA	p.G1522G	CHD5_uc001alz.1_Silent_p.G379G|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1522					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGCTGTACTTCCCGTTGACAT	0.502000													6	29					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7725052	7725052	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:7725052C>T	uc001aoi.2	+	9	2652	c.2445C>T	c.(2443-2445)ACC>ACT	p.T815T		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	815					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CCCCCTTCACCCAGGCAGAGA	0.697000													17	115					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12854125	12854125	+	Missense_Mutation	SNP	C	T	T	rs141554509		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:12854125C>T	uc001auj.1	+	3	452	c.349C>T	c.(349-351)CCT>TCT	p.P117S		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	117											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCAGATGGCCTGGAGCCTG	0.537000													53	307					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16455930	16455930	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:16455930C>T	uc001aya.1	-	16	2961	c.2824G>A	c.(2824-2826)GAC>AAC	p.D942N		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	942	SAM.|Cytoplasmic (Potential).|Negatively regulates interaction with ARHGEF16.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTGACTTACTCGTTGGTCATC	0.637000													23	123					0	0	1	0	0
PQLC2	54896	broad.mit.edu	37	1	19653818	19653818	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:19653818C>T	uc001bby.2	+	8	1068	c.716C>T	c.(715-717)CCC>CTC	p.P239L	PQLC2_uc001bbz.2_Missense_Mutation_p.P174L|PQLC2_uc001bca.2_Missense_Mutation_p.P239L|PQLC2_uc001bcb.2_Missense_Mutation_p.P128L|PQLC2_uc001bcc.2_Missense_Mutation_p.P128L	NM_017765	NP_060235	Q6ZP29	PQLC2_HUMAN	PQ loop repeat containing 2 isoform 1	239	PQ-loop 2.|Extracellular (Potential).					integral to membrane					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;1.89e-05)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CTCAAAAACCCCGAGGAGGGC	0.632000													18	90					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22159011	22159011	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:22159011G>A	uc001bfj.2	-	81	11224	c.11184C>T	c.(11182-11184)CTC>CTT	p.L3728L	HSPG2_uc001bfi.2_5'Flank|HSPG2_uc009vqd.2_Silent_p.L3729L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	3728	Laminin G-like 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TTCCCCCCACGAGGCCGAAGG	0.662000													23	97					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22204953	22204953	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:22204953G>A	uc001bfj.2	-	20	2630	c.2590C>T	c.(2590-2592)CAG>TAG	p.Q864*	HSPG2_uc009vqd.2_Nonsense_Mutation_p.Q865*	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	864	Laminin EGF-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCGCCGGGCTGGATGGGGTTG	0.687000													4	21					0	0	1	0	0
HNRNPR	10236	broad.mit.edu	37	1	23650088	23650088	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:23650088G>A	uc001bgr.3	-	6	795	c.636C>T	c.(634-636)ACC>ACT	p.T212T	HNRNPR_uc001bgp.3_Silent_p.T212T|HNRNPR_uc009vqk.2_Silent_p.T111T|HNRNPR_uc001bgs.3_Silent_p.T111T|HNRNPR_uc010odw.1_Silent_p.T174T|HNRNPR_uc010odx.1_Intron|HNRNPR_uc009vql.2_Silent_p.T73T	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	212	RRM 1.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		TTCCACAGAAGGTGATAAATG	0.433000													22	112					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27736635	27736636	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:27736635_27736636GG>AA	uc001bof.1	-	8	1105_1106	c.889_890CC>TT	c.(889-891)CCA>TTA	p.P297L	WASF2_uc010ofl.1_Intron	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	297					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		TGGATGGCTTGGGCTGACCACA	0.559000													9	67					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29649925	29649926	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:29649925_29649926GG>AA	uc001bru.2	+	28	4011_4012	c.3901_3902GG>AA	c.(3901-3903)GGC>AAC	p.G1301N	PTPRU_uc001brv.2_Missense_Mutation_p.G1297N|PTPRU_uc001brw.2_Missense_Mutation_p.G1291N|PTPRU_uc009vtq.2_Missense_Mutation_p.G1297N|PTPRU_uc009vtr.2_Missense_Mutation_p.G1288N|PTPRU_uc001brx.2_Missense_Mutation_p.G27N	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1301	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GCAGCAATATGGCCTCATGGAG	0.614000													4	16					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	33990614	33990614	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:33990614G>A	uc001bxn.1	-	65	9861	c.9832C>T	c.(9832-9834)CTG>TTG	p.L3278L	CSMD2_uc001bxm.1_Silent_p.L3422L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3278	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCTTTCCACAGGGAATTCTTG	0.498000													20	175					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34006750	34006750	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:34006750C>T	uc001bxn.1	-	58	9034	c.9005G>A	c.(9004-9006)GGA>GAA	p.G3002E	CSMD2_uc001bxm.1_Missense_Mutation_p.G3146E	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3002	Extracellular (Potential).|Sushi 22.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGGCTTGGTTCCATTCCATGT	0.488000													31	142					0	0	1	0	0
MEAF6	64769	broad.mit.edu	37	1	37980287	37980288	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:37980287_37980288CC>TT	uc001cbg.1	-	1	77_78	c.60_61GG>AA	c.(58-63)GCGGAG>GCAAAG	p.E21K	MEAF6_uc001cbd.1_5'Flank|MEAF6_uc001cbe.1_Missense_Mutation_p.E21K|MEAF6_uc009vvd.1_RNA|MEAF6_uc001cbf.1_RNA|MEAF6_uc001cbh.1_Missense_Mutation_p.E21K	NM_022756	NP_073593	Q9HAF1	EAF6_HUMAN	MYST/Esa1-associated factor 6	21	Potential.				histone H2A acetylation|histone H3-K14 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|NuA4 histone acetyltransferase complex|nucleolus	protein binding				0						TTCACGAGCTCCGCCAGCTCCC	0.757000													3	19					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39816481	39816481	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:39816481C>T	uc010oiu.1	+	7	6441	c.6310C>T	c.(6310-6312)CGT>TGT	p.R2104C	MACF1_uc010ois.1_Missense_Mutation_p.R1602C|MACF1_uc001cda.1_Missense_Mutation_p.R1510C|MACF1_uc001cdc.1_Missense_Mutation_p.R689C|MACF1_uc001cdb.1_Missense_Mutation_p.R689C	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3669	LRR 11.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CATTCAGAATCGTGCCACCTC	0.443000													6	53					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42046504	42046504	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:42046504C>T	uc001cgz.3	-	4	5178	c.3965G>A	c.(3964-3966)CGT>CAT	p.R1322H	HIVEP3_uc001cha.3_Missense_Mutation_p.R1322H|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1322					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGTCTGAACACGGACAGGCAC	0.597000													23	108					0	0	1	0	0
FOXJ3	22887	broad.mit.edu	37	1	42657234	42657234	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:42657234G>A	uc001che.2	-	11	1403	c.1091C>T	c.(1090-1092)TCG>TTG	p.S364L	FOXJ3_uc001chf.2_Missense_Mutation_p.S364L|FOXJ3_uc001chg.2_Missense_Mutation_p.S364L|FOXJ3_uc001chh.1_Missense_Mutation_p.S330L	NM_014947	NP_055762	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	364					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)	2	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CTGTGCAACCGAATTACTGCC	0.577000													44	261					0	0	1	0	0
CCDC30	728621	broad.mit.edu	37	1	43102988	43102988	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:43102988G>A	uc009vwk.1	+	11	1687	c.1577G>A	c.(1576-1578)CGA>CAA	p.R526Q	CCDC30_uc001chm.2_Missense_Mutation_p.R224Q|CCDC30_uc001chn.2_Missense_Mutation_p.R315Q	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30	526											0						GTAGAACTACGAGATAAGAGA	0.303000													7	36					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44035274	44035274	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:44035274C>T	uc001cjr.2	+	6	733	c.393C>T	c.(391-393)CCC>CCT	p.P131P	PTPRF_uc001cjq.3_Silent_p.P131P|PTPRF_uc001cjs.2_Silent_p.P131P|PTPRF_uc001cjt.3_Silent_p.P131P	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	131	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AACAGCTGCCCCCTGGGTTCC	0.602000													16	86					0	0	1	0	0
TMEM53	79639	broad.mit.edu	37	1	45120617	45120617	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:45120617T>C	uc001cmc.2	-	3	484	c.448A>G	c.(448-450)AAC>GAC	p.N150D	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_Missense_Mutation_p.N77D|TMEM53_uc009vxh.1_Missense_Mutation_p.N33D|TMEM53_uc010ola.1_Missense_Mutation_p.N33D	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	150						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					CCTACCAGGTTGCTGTCACCA	0.672000													6	26					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46295125	46295125	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:46295125C>T	uc001cov.2	+	3	623	c.340C>T	c.(340-342)CCT>TCT	p.P114S	MAST2_uc001cow.2_Missense_Mutation_p.P114S	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	114					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GCAGCTGCTCCCTTTGTCCAG	0.398000													11	48					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46489570	46489570	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:46489570C>T	uc001cov.2	+	15	1981	c.1698C>T	c.(1696-1698)TTC>TTT	p.F566F	MAST2_uc001cow.2_Silent_p.F566F|MAST2_uc001coy.1_Silent_p.F240F|MAST2_uc001coz.1_Silent_p.F451F|MAST2_uc009vya.2_Silent_p.F488F|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	566	Protein kinase.				regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					TACTGACTTTCGCTGAGAACC	0.532000													10	64					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47351161	47351161	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:47351161G>A	uc001cqo.1	-	4		c.500C>T			CYP4Z2P_uc009vyn.1_RNA	NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0						ACATCATGGTGATGAATATTT	0.483000													4	34					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47400826	47400826	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:47400826C>T	uc001cqp.3	-	6	687	c.636G>A	c.(634-636)AGG>AGA	p.R212R	CYP4A11_uc001cqq.2_Silent_p.R212R|CYP4A11_uc010omm.1_Intron	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	212					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	ACTGAGAATTCCTGAGGGAGA	0.517000													10	89					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47406926	47406926	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:47406926G>A	uc001cqp.3	-	1	231	c.180C>T	c.(178-180)TTC>TTT	p.F60F	CYP4A11_uc001cqq.2_Silent_p.F60F|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	60					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GGATGTGCCCGAAGAGCCAGT	0.592000													12	66					0	0	1	0	0
ELAVL4	1996	broad.mit.edu	37	1	50666738	50666738	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:50666738C>T	uc001csb.2	+	7	1299	c.1031C>T	c.(1030-1032)ACC>ATC	p.T344I	ELAVL4_uc001cry.3_Missense_Mutation_p.T333I|ELAVL4_uc001crz.3_Missense_Mutation_p.T330I|ELAVL4_uc001csa.3_Missense_Mutation_p.T347I|ELAVL4_uc001csc.3_Missense_Mutation_p.T330I|ELAVL4_uc010omz.1_Missense_Mutation_p.T335I	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	344	RRM 3.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						GGCTTTGTCACCATGACCAAC	0.522000													17	86					0	0	1	0	0
MAGOH	4116	broad.mit.edu	37	1	53699256	53699256	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:53699256C>T	uc001cvf.1	-	3	304	c.216G>A	c.(214-216)GAG>GAA	p.E72E	MAGOH_uc010ont.1_Intron	NM_002370	NP_002361	P61326	MGN_HUMAN	mago-nashi homolog	72				ED->RK: Fully active.|E->R: Abolishes interaction with WIBG/PYM leading to increase EJC association with splices mRNAs; when associated with R-68; K-73 and R-117.	mRNA 3'-end processing|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|exon-exon junction complex|nuclear speck	protein binding|RNA binding				0						ATGCATCATCCTCTTTGGTAA	0.418000													30	190					0	0	1	0	0
LRP8	7804	broad.mit.edu	37	1	53741397	53741397	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:53741397G>A	uc001cvi.1	-	6	1054	c.912C>T	c.(910-912)TTC>TTT	p.F304F	LRP8_uc001cvh.1_5'UTR|LRP8_uc001cvk.1_Intron|LRP8_uc001cvj.1_Silent_p.F304F|LRP8_uc001cvl.1_Silent_p.F175F	NM_004631	NP_004622	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein	304	LDL-receptor class A 7.|Extracellular (Potential).				cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity				0						CCCCACACTGGAACTCGTCCC	0.592000													8	46					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57209928	57209928	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:57209928C>T	uc001cym.3	-	10	1805	c.1399G>A	c.(1399-1401)GAG>AAG	p.E467K	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	467										ovary(3)|skin(2)	5						TCCAAAACCTCCAGATGCCCA	0.453000													3	10					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57347158	57347158	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:57347158G>A	uc001cyo.2	+	5	637	c.505G>A	c.(505-507)GAT>AAT	p.D169N		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	169	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GAGTGTGTACGATGCCAGTTA	0.393000													12	64					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57480751	57480751	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:57480751C>T	uc001cys.1	-	14	1923	c.1249G>A	c.(1249-1251)GAT>AAT	p.D417N	DAB1_uc001cyt.1_Missense_Mutation_p.D415N|DAB1_uc001cyq.1_Missense_Mutation_p.D415N|DAB1_uc001cyr.1_Missense_Mutation_p.D331N|DAB1_uc009vzw.1_Missense_Mutation_p.D399N|DAB1_uc009vzx.1_Missense_Mutation_p.D417N	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	450					cell differentiation|nervous system development					skin(2)|ovary(1)	3						ATCTGGAAATCCTTAAACGTT	0.592000													8	67					0	0	1	0	0
ATG4C	84938	broad.mit.edu	37	1	63307111	63307112	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:63307111_63307112CC>TT	uc001dat.2	+	10	1264_1265	c.1102_1103CC>TT	c.(1102-1104)CCT>TTT	p.P368F	ATG4C_uc001dau.2_Missense_Mutation_p.P368F	NM_178221	NP_835739	Q96DT6	ATG4C_HUMAN	APG4 autophagy 4 homolog C isoform 8	368					autophagic vacuole assembly|protein targeting to membrane|proteolysis	cytosol|extracellular region	cysteine-type endopeptidase activity			ovary(1)	1						ATTCCACTGCCCTTCTCCCAAA	0.302000													6	26					0	0	1	0	0
DNAJC6	9829	broad.mit.edu	37	1	65852574	65852574	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:65852574C>T	uc001dcd.1	+	8	1068	c.904C>T	c.(904-906)CAC>TAC	p.H302Y	DNAJC6_uc001dcc.1_Missense_Mutation_p.H333Y|DNAJC6_uc010opc.1_Missense_Mutation_p.H289Y|DNAJC6_uc001dce.1_Missense_Mutation_p.H359Y	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	302	C2 tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						TTCCATGTATCACTTGAGGTC	0.413000													14	60					0	0	1	0	0
WLS	79971	broad.mit.edu	37	1	68591929	68591930	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:68591929_68591930GG>AA	uc001def.1	-	12	1876_1877	c.1605_1606CC>TT	c.(1603-1608)ACCCGC>ACTTGC	p.R536C	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Intron|WLS_uc001deg.1_Missense_Mutation_p.R445C|WLS_uc009wbf.1_3'UTR	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	536	Cytoplasmic (Potential).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						GCCTCCTTGCGGGTCAACTTGT	0.599000													5	54					0	0	1	0	0
RPE65	6121	broad.mit.edu	37	1	68905282	68905282	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:68905282G>A	uc001dei.1	-	7	741	c.687C>T	c.(685-687)TTC>TTT	p.F229F		NM_000329	NP_000320	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein	229					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			ovary(1)	1						CACTGCAGGGGAATTGTACAA	0.373000													8	60					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70505037	70505037	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:70505037C>T	uc001dep.2	+	19	3446	c.3416C>T	c.(3415-3417)CCA>CTA	p.P1139L	LRRC7_uc009wbg.2_Missense_Mutation_p.P423L|LRRC7_uc001deq.2_Missense_Mutation_p.P380L	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1139						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GAGCTGCCCCCAACTGATAGG	0.577000													16	96					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75602798	75602798	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:75602798G>A	uc001dgo.2	+	4	783	c.119G>A	c.(118-120)GGA>GAA	p.G40E	LHX8_uc001dgq.2_5'UTR	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	40						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AGCCCCGAGGGAGCGGGGGAC	0.726000													11	58					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75608843	75608843	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:75608843C>T	uc001dgo.2	+	6	1094	c.430C>T	c.(430-432)CAT>TAT	p.H144Y	LHX8_uc001dgq.2_Missense_Mutation_p.H83Y	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	144	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						GAGACACATCCATTCTACTGA	0.458000													19	97					0	0	1	0	0
ASB17	127247	broad.mit.edu	37	1	76384833	76384833	+	Missense_Mutation	SNP	C	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:76384833C>A	uc001dhe.1	-	3	832	c.692G>T	c.(691-693)AGT>ATT	p.S231I	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	231					intracellular signal transduction					ovary(1)	1						TCTTCCTAAACTCAGCTGTGT	0.264000													4	19					0.00909568	0.00911219	1	1	0
SH3GLB1	51100	broad.mit.edu	37	1	87208012	87208012	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:87208012C>T	uc001dlw.2	+	8	1209	c.883C>T	c.(883-885)CCT>TCT	p.P295S	SH3GLB1_uc001dlx.2_Missense_Mutation_p.P316S|SH3GLB1_uc001dly.2_Missense_Mutation_p.P324S|SH3GLB1_uc001dlz.2_Missense_Mutation_p.P195S	NM_016009	NP_057093	Q9Y371	SHLB1_HUMAN	SH3-containing protein SH3GLB1	295					anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding				0		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		AATCACCTCTCCTTCCAACCT	0.448000													8	47					0	0	1	0	0
GBP5	115362	broad.mit.edu	37	1	89730439	89730439	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:89730439C>T	uc001dnc.2	-	8	1616	c.1079G>A	c.(1078-1080)AGG>AAG	p.R360K	GBP5_uc001dnd.2_Missense_Mutation_p.R360K|GBP5_uc001dne.1_Missense_Mutation_p.R360K	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	360						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		AATGGCCTCCCTCTCACTGGT	0.478000													11	70					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91740286	91740286	+	Splice_Site	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:91740286C>T	uc001doa.3	-	33	3768	c.3668_splice	c.e33+1	p.R1223_splice	HFM1_uc009wdb.2_Splice_Site|HFM1_uc010osu.1_Splice_Site_p.R902_splice|HFM1_uc001dob.3_Splice_Site_p.R411_splice|HFM1_uc010osv.1_Splice_Site_p.R907_splice	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein								ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TATATTTGTACCTTGATATAC	0.323000													5	27					0	0	1	0	0
HSP90B3P	343477	broad.mit.edu	37	1	92109137	92109137	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:92109137G>A	uc010osx.1	+	3	1164	c.1164G>A	c.(1162-1164)AAG>AAA	p.K388K		NR_003130				SubName: Full=cDNA FLJ58812, highly similar to Endoplasmin (Heat shock protein 90kDa beta member 1);												0						AAATTGAGAAGGCTGTGGTGT	0.458000													6	17					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94473802	94473802	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:94473802G>A	uc001dqh.2	-	42	5991	c.5887C>T	c.(5887-5889)CGC>TGC	p.R1963C	ABCA4_uc001dqi.1_Missense_Mutation_p.R82C	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1963	ABC transporter 2.|Cytoplasmic.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TCTCCAGGGCGAACTCCGACA	0.522000													8	63					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94669541	94669541	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:94669541G>A	uc001dqj.3	-	8	1076	c.707C>T	c.(706-708)TCC>TTC	p.S236F	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.S236F	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	236					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity	p.S236S(1)		breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATTTCTAGTGGACTCCAATTC	0.348000													5	31					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94674859	94674859	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:94674859G>A	uc001dqj.3	-	4	757	c.388C>T	c.(388-390)CAG>TAG	p.Q130*	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Nonsense_Mutation_p.Q130*	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	130					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		AACACTTCCTGGAAGAGATCG	0.328000													10	23					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97658765	97658765	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:97658765C>T	uc001drv.2	-	20	2619	c.2482G>A	c.(2482-2484)GAA>AAA	p.E828K		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	828					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CAGTAGTCTTCGATCACAGTG	0.438000													5	24					0	0	1	0	0
SASS6	163786	broad.mit.edu	37	1	100587028	100587028	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:100587028G>A	uc001dsu.2	-	5	530	c.389C>T	c.(388-390)CCT>CTT	p.P130L	SASS6_uc009wdz.2_5'UTR	NM_194292	NP_919268	Q6UVJ0	SAS6_HUMAN	spindle assembly abnormal protein 6	130					centriole replication	centriole				upper_aerodigestive_tract(1)|ovary(1)	2		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		ATGCTTAAAAGGATTTGTCTC	0.348000													9	57					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101196829	101196829	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:101196829T>C	uc001dti.2	+	6	1400	c.1280T>C	c.(1279-1281)GTT>GCT	p.V427A	VCAM1_uc001dtj.2_Missense_Mutation_p.V335A|VCAM1_uc010ouj.1_Missense_Mutation_p.V365A	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	427	Ig-like C2-type 5.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGCTGCAAGGTTCCTAGCGTG	0.463000													8	45					0	0	1	0	0
S1PR1	1901	broad.mit.edu	37	1	101705685	101705685	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:101705685C>T	uc001dud.2	+	2	1659	c.1145C>T	c.(1144-1146)TCC>TTC	p.S382F	S1PR1_uc009weg.2_Missense_Mutation_p.S382F	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	382	Cytoplasmic (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						AACTCTTCTTCCTAGAACTGG	0.532000													6	38					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103427792	103427792	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:103427792C>T	uc001dul.2	-	40	3372	c.3054G>A	c.(3052-3054)GGG>GGA	p.G1018G	COL11A1_uc001duk.2_Silent_p.G214G|COL11A1_uc001dum.2_Silent_p.G1030G|COL11A1_uc001dun.2_Silent_p.G979G|COL11A1_uc009weh.2_Silent_p.G902G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1018	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GTCCATCTTTCCCTGAGATAC	0.383000													9	66					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108247175	108247175	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:108247175C>T	uc001dvk.1	-	17	1756	c.1702G>A	c.(1702-1704)GGT>AGT	p.G568S	VAV3_uc010ouw.1_Missense_Mutation_p.G568S|VAV3_uc001dvl.1_Missense_Mutation_p.G392S|VAV3_uc010oux.1_Missense_Mutation_p.G568S	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	568					angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GACTTACCACCAGAATTAACT	0.338000													10	47					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109268482	109268482	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:109268482G>A	uc001dvx.2	+	6	967	c.967G>A	c.(967-969)GAT>AAT	p.D323N	FNDC7_uc010ova.1_Missense_Mutation_p.D90N	NM_001144937	NP_001138409	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	324	Fibronectin type-III 4.					extracellular region				ovary(1)|skin(1)	2		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		TGTGAAGAGTGATGATGGCTT	0.453000													23	134					0	0	1	0	0
OVGP1	5016	broad.mit.edu	37	1	111966312	111966312	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:111966312G>A	uc001eba.2	-	5	392	c.336C>T	c.(334-336)TCC>TCT	p.S112S	OVGP1_uc001eaz.2_Silent_p.S74S|OVGP1_uc010owb.1_5'UTR|OVGP1_uc010owc.1_Silent_p.S102S	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	112					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TGGCAAATGTGGACAACATAG	0.443000													12	84					0	0	1	0	0
ADORA3	140	broad.mit.edu	37	1	112042717	112042717	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:112042717G>A	uc001ebh.3	-	2	1579	c.812C>T	c.(811-813)TCC>TTC	p.S271F	ADORA3_uc001ebg.3_Intron|ADORA3_uc001ebf.2_Intron	NM_000677	NP_000668	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 2	271	Helical; Name=7; (By similarity).				activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GTTGGCATGGGACAGCAGGAT	0.438000													5	32					0	0	1	0	0
AP4B1	10717	broad.mit.edu	37	1	114437951	114437951	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:114437951G>A	uc001eeb.2	-	10	2099	c.1956C>T	c.(1954-1956)TTC>TTT	p.F652F	uc001edv.1_Intron|AP4B1_uc001eec.2_Silent_p.F484F|AP4B1_uc001eed.2_Silent_p.F652F|AP4B1_uc010owp.1_Silent_p.F553F|AP4B1_uc001eea.1_3'UTR|AP4B1_uc001eee.1_3'UTR	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	652					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTCAGGATGGAATTCTCCCC	0.502000													10	84					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115828985	115828985	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:115828985C>T	uc001efu.1	-	3	601	c.432G>A	c.(430-432)GGG>GGA	p.G144G		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	144					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	TGGTCTTATCCCCAACCCACA	0.517000													18	115					0	0	1	0	0
VANGL1	81839	broad.mit.edu	37	1	116206470	116206470	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:116206470C>T	uc001efv.1	+	4	664	c.393C>T	c.(391-393)ATC>ATT	p.I131I	VANGL1_uc009wgy.1_Silent_p.I129I|VANGL1_uc001efw.1_Silent_p.I131I	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	131	Helical; Name=1; (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTGCCTTCATCCTTTTACCTC	0.522000													15	54					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427525	119427525	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:119427525G>A	uc001ehl.1	-	8	1636	c.1321C>T	c.(1321-1323)CCT>TCT	p.P441S	TBX15_uc009whj.1_Missense_Mutation_p.P265S	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	547						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CCGTTGGAAGGAGAAGAACAG	0.522000													13	32					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427740	119427740	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:119427740G>A	uc001ehl.1	-	8	1421	c.1106C>T	c.(1105-1107)TCC>TTC	p.S369F	TBX15_uc009whj.1_Missense_Mutation_p.S193F	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	475						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CTGAAACTGGGAAGTGGGAAA	0.572000													12	32					0	0	1	0	0
NBPF9	400818	broad.mit.edu	37	1	144618109	144618109	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:144618109G>A	uc009wig.1	+	6	382	c.306G>A	c.(304-306)CAG>CAA	p.Q102Q	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Silent_p.Q33Q|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Silent_p.Q33Q|NBPF9_uc010oyg.1_Silent_p.Q67Q|NBPF9_uc009wii.1_5'UTR	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	102	Potential.					cytoplasm					0						TTCACTCTCAGGAACGAGAGC	0.468000													34	460					0	0	1	0	0
TXNIP	10628	broad.mit.edu	37	1	145438936	145438936	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:145438936G>A	uc001enn.3	+	1	475	c.134G>A	c.(133-135)AGG>AAG	p.R45K	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_5'Flank	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	45					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAAGCCGTTAGGATCCTGGCT	0.542000													11	57					0	0	1	0	0
NBPF16	728936	broad.mit.edu	37	1	148741790	148741790	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:148741790C>T	uc010pba.1	+	3	467	c.276C>T	c.(274-276)CTC>CTT	p.L92L	NBPF16_uc009wkt.1_5'UTR	NM_001102663	NP_001096133			hypothetical protein LOC728936												0	all_hematologic(923;0.032)					CTGAGGAGCTCAGGTGAGGGG	0.527000													21	88					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150443549	150443549	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:150443549C>T	uc009wlr.2	+	11	2326	c.2125C>T	c.(2125-2127)CAG>TAG	p.Q709*	RPRD2_uc010pcc.1_Nonsense_Mutation_p.Q683*|RPRD2_uc001eup.3_Nonsense_Mutation_p.Q683*	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	709	Ser-rich.						protein binding			ovary(1)	1						CTCAGACTTCCAGCGTGGCCC	0.527000													10	53					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150445225	150445225	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:150445225C>T	uc009wlr.2	+	11	4002	c.3801C>T	c.(3799-3801)TTC>TTT	p.F1267F	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Silent_p.F1241F	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1267	Pro-rich.						protein binding			ovary(1)	1						GAATTCCTTTCCCTACCCCAC	0.612000													20	122					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187698	152187698	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:152187698T>G	uc001ezt.1	-	3	6483	c.6407A>C	c.(6406-6408)CAC>CCC	p.H2136P		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2136					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTAGAGCCGTGTTGTCCGTA	0.562000													17	618					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152188442	152188442	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:152188442C>T	uc001ezt.1	-	3	5739	c.5663G>A	c.(5662-5664)GGA>GAA	p.G1888E		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1888	20.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGCCAGATCCATGCTGAGT	0.537000													27	749					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276826	152276826	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:152276826C>T	uc001ezu.1	-	3	10572	c.10536G>A	c.(10534-10536)CAG>CAA	p.Q3512Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3512	Ser-rich.|Filaggrin 21.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGTCCGCCTGAGTGGAAG	0.562000									Ichthyosis				48	300					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281004	152281004	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:152281004C>T	uc001ezu.1	-	3	6394	c.6358G>A	c.(6358-6360)GAT>AAT	p.D2120N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2120	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGCCTGATCATAATGGGAT	0.572000									Ichthyosis				50	309					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152285639	152285639	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:152285639C>T	uc001ezu.1	-	3	1759	c.1723G>A	c.(1723-1725)GAA>AAA	p.E575K	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	575	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGATTGTTCCTCATTTCGT	0.557000									Ichthyosis				75	430					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154573527	154573527	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:154573527G>A	uc001ffh.2	-	2	1791	c.1591C>T	c.(1591-1593)CAT>TAT	p.H531Y	ADAR_uc001ffj.2_Missense_Mutation_p.H531Y|ADAR_uc001ffi.2_Missense_Mutation_p.H531Y|ADAR_uc001ffk.2_Missense_Mutation_p.H236Y|ADAR_uc001ffl.1_Missense_Mutation_p.H236Y	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	531	DRBM 1.				adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		CGAGGTTCATGGGGTGGTCCA	0.527000													18	154					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155658732	155658732	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:155658732C>T	uc001fln.2	-	1	60	c.36G>A	c.(34-36)ACG>ACA	p.T12T	YY1AP1_uc010pgi.1_5'Flank|YY1AP1_uc001flh.2_5'Flank|YY1AP1_uc009wqt.2_5'Flank|YY1AP1_uc001flk.2_5'Flank|YY1AP1_uc001fll.2_5'Flank|YY1AP1_uc009wqv.2_5'Flank|YY1AP1_uc001flm.2_5'Flank|YY1AP1_uc001fli.2_5'Flank|YY1AP1_uc009wqu.2_5'Flank|YY1AP1_uc001flj.2_5'Flank|YY1AP1_uc009wqw.2_5'Flank|YY1AP1_uc001flo.2_5'UTR|YY1AP1_uc001flp.2_5'UTR|YY1AP1_uc010pgj.1_Silent_p.T12T|YY1AP1_uc009wqx.2_5'Flank|YY1AP1_uc010pgk.1_5'Flank|DAP3_uc001flq.2_5'Flank|DAP3_uc001flr.2_5'Flank|DAP3_uc001fls.2_5'Flank|DAP3_uc010pgl.1_5'Flank|DAP3_uc001flt.2_5'Flank|DAP3_uc001flu.2_5'Flank|DAP3_uc010pgm.1_5'Flank	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	12					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TCCCTGGGTTCGTCGCCGCGG	0.706000													7	13					0	0	1	0	0
C1orf85	112770	broad.mit.edu	37	1	156263937	156263937	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:156263937C>T	uc001foh.2	-	4	683	c.670G>A	c.(670-672)GGA>AGA	p.G224R	C1orf85_uc001fof.3_5'Flank|C1orf85_uc001fog.1_Intron|C1orf85_uc001foi.2_Missense_Mutation_p.G224R|C1orf85_uc009wrx.2_Missense_Mutation_p.G157R|C1orf85_uc001foj.2_Missense_Mutation_p.G138R	NM_144580	NP_653181	Q8WWB7	NCUG1_HUMAN	kidney predominant protein NCU-G1 precursor	224	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)	2	Hepatocellular(266;0.158)					GGAGAGGCTCCAATCAGGGCC	0.632000													18	70					0	0	1	0	0
FCRL3	115352	broad.mit.edu	37	1	157665297	157665297	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:157665297G>A	uc001frb.2	-	8	1525	c.1233C>T	c.(1231-1233)CCC>CCT	p.P411P	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.P411P|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.P137P|FCRL3_uc001frc.1_Silent_p.P411P	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	411	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					ACAGGATCGGGGGAGAGCCTC	0.597000													13	70					0	0	1	0	0
CD1C	911	broad.mit.edu	37	1	158259858	158259858	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158259858C>T	uc001fru.2	+	1	296	c.4C>T	c.(4-6)CTG>TTG	p.L2L	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	2					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					AAATGACATGCTGTTTCTGCA	0.438000													18	73					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158300834	158300834	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158300834G>A	uc001frx.2	-	2	188	c.80C>T	c.(79-81)TCC>TTC	p.S27F	CD1B_uc001frw.2_5'UTR|CD1B_uc010pic.1_Missense_Mutation_p.S27F	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	27	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					AACATGAAAGGAGGTCGGCCC	0.463000													31	212					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158326534	158326534	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158326534C>T	uc001fse.2	+	6	1254	c.1015C>T	c.(1015-1017)CTT>TTT	p.L339F	CD1E_uc001fsd.2_3'UTR|CD1E_uc001fsk.2_Missense_Mutation_p.L249F|CD1E_uc001fsj.2_Intron|CD1E_uc001fsc.2_Missense_Mutation_p.L150F|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Missense_Mutation_p.L95F|CD1E_uc001fsf.2_Intron|CD1E_uc001fry.2_Intron|CD1E_uc001fsg.2_3'UTR|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Intron|CD1E_uc009wsv.2_Missense_Mutation_p.L240F|CD1E_uc001frz.2_Intron|CD1E_uc009wsw.2_Intron	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	339					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					TAAGAACATTCTTTCTCCCCA	0.328000													17	90					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158369106	158369106	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158369106G>A	uc010pih.1	-	1	151	c.151C>T	c.(151-153)CGC>TGC	p.R51C		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					CAGCTGAAGCGAATAACGGCC	0.483000													4	23					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158549611	158549611	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158549611C>T	uc010pin.1	-	1	79	c.79G>A	c.(79-81)GAA>AAA	p.E27K		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	27	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGAATGAATTCCTTCAGGATT	0.363000													10	75					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158597465	158597465	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158597465C>T	uc001fst.1	-	40	5813	c.5614G>A	c.(5614-5616)GAG>AAG	p.E1872K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1872	Spectrin 18.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ACTCGGGTCTCATGGACAGCA	0.408000													15	93					0	0	1	0	0
OR6K6	128371	broad.mit.edu	37	1	158725074	158725074	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158725074C>T	uc001fsw.1	+	1	469	c.469C>T	c.(469-471)CCA>TCA	p.P157S		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	157	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					TATCTGCAATCCACTCCGTTA	0.478000													17	78					0	0	1	0	0
MNDA	4332	broad.mit.edu	37	1	158815404	158815404	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158815404G>A	uc001fsz.1	+	5	798	c.598G>A	c.(598-600)GTG>ATG	p.V200M		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	200	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					CCAACGGCAGGTGGATGCAAG	0.403000													6	45					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158911970	158911970	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:158911970G>A	uc001ftb.2	+	5	1028	c.783G>A	c.(781-783)AGG>AGA	p.R261R	PYHIN1_uc001ftc.2_Silent_p.R252R|PYHIN1_uc001ftd.2_Silent_p.R261R|PYHIN1_uc001fte.2_Silent_p.R252R	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	261	HIN-200.				cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					ACTTGAAGAGGAAATTCATTA	0.363000													7	25					0	0	1	0	0
CADM3	57863	broad.mit.edu	37	1	159161803	159161803	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:159161803G>A	uc001ftl.2	+	2	308	c.166G>A	c.(166-168)GAG>AAG	p.E56K	CADM3_uc009wsx.1_Missense_Mutation_p.E90K|CADM3_uc009wsy.1_Missense_Mutation_p.E56K|CADM3_uc001ftk.2_Missense_Mutation_p.E90K	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	56	Ig-like V-type.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					GAAAGATCACGAGGACTCATC	0.507000													8	46					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159283697	159283697	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:159283697G>A	uc010piu.1	-	1	753	c.753C>T	c.(751-753)ATC>ATT	p.I251I		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					AGCCATAGTGGATGATGACCA	0.527000													10	35					0	0	1	0	0
APCS	325	broad.mit.edu	37	1	159558188	159558188	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:159558188C>T	uc001ftv.2	+	2	458	c.362C>T	c.(361-363)TCA>TTA	p.S121L		NM_001639	NP_001630	P02743	SAMP_HUMAN	serum amyloid P component precursor	121	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			ovary(1)|breast(1)	2	all_hematologic(112;0.0429)					GAGTCCTCATCAGGTATTGCT	0.468000													4	40					0	0	1	0	0
USF1	7391	broad.mit.edu	37	1	161010423	161010423	+	Silent	SNP	G	A	A	rs138288820		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:161010423G>A	uc001fxi.2	-	9	852	c.657C>T	c.(655-657)ATC>ATT	p.I219I	F11R_uc010pjw.1_5'Flank|F11R_uc001fxf.3_5'Flank|TSTD1_uc010pjx.1_5'Flank|TSTD1_uc009wtw.2_5'Flank|TSTD1_uc001fxh.3_5'Flank|USF1_uc001fxj.2_Silent_p.I160I	NM_007122	NP_009053	P22415	USF1_HUMAN	upstream stimulatory factor 1 isoform 1	219	Helix-loop-helix motif.				cellular response to insulin stimulus|glucose homeostasis|late viral mRNA transcription|lipid homeostasis|positive regulation of transcription from RNA polymerase II promoter by glucose|response to hypoxia|response to UV	transcription factor complex	bHLH transcription factor binding|histone deacetylase binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(52;6.73e-18)|Breast(13;0.012)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			AGAGCTGCACGATCCAGTTGT	0.542000													6	57					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161024188	161024188	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:161024188G>A	uc001fxl.2	-	5	850	c.504C>T	c.(502-504)AAC>AAT	p.N168N	ARHGAP30_uc001fxk.2_Silent_p.N168N|ARHGAP30_uc001fxm.2_Silent_p.N14N|ARHGAP30_uc009wtx.2_5'UTR|ARHGAP30_uc001fxn.1_Silent_p.N14N	NM_001025598	NP_001020769	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30 isoform 1	168	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|upper_aerodigestive_tract(1)	3	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CGATGGCCAGGTTGCGAGCAT	0.597000													5	29					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165173164	165173164	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:165173164G>A	uc001gcy.1	-	8	1323	c.1102C>T	c.(1102-1104)CCC>TCC	p.P368S	LMX1A_uc001gcz.1_Missense_Mutation_p.P368S|LMX1A_uc001gcw.1_Missense_Mutation_p.P86S|LMX1A_uc001gcx.1_Missense_Mutation_p.P119S	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	368						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					TGGTCAATGGGGTTTCCCACT	0.488000													10	76					0	0	1	0	0
LMX1A	4009	broad.mit.edu	37	1	165183001	165183001	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:165183001C>T	uc001gcy.1	-	4	767	c.546G>A	c.(544-546)GGG>GGA	p.G182G	LMX1A_uc001gcz.1_Silent_p.G182G|LMX1A_uc001gcw.1_5'Flank|LMX1A_uc001gcx.1_5'Flank	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	182						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					CAGTTCCTTTCCCTGCCCCAT	0.493000													16	113					0	0	1	0	0
KIFAP3	22920	broad.mit.edu	37	1	170001039	170001039	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:170001039G>T	uc001ggv.2	-	8	1100	c.829C>A	c.(829-831)CAG>AAG	p.Q277K		NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	277					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CGTAATAGCTGTTCCTGTTTT	0.348000													13	105					2.32078e-09	2.34057e-09	1	1	0
FMO1	2326	broad.mit.edu	37	1	171244519	171244519	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:171244519C>T	uc009wvz.2	+	4	492	c.356C>T	c.(355-357)TCT>TTT	p.S119F	FMO1_uc010pme.1_Missense_Mutation_p.S56F|FMO1_uc001ghl.2_Missense_Mutation_p.S119F|FMO1_uc001ghm.2_Missense_Mutation_p.S119F|FMO1_uc001ghn.2_Missense_Mutation_p.S119F	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	119					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGCTCAGATTCTGCTGTCTCT	0.428000													12	60					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171621175	171621175	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:171621175G>A	uc001ghu.2	-	1	599	c.577C>T	c.(577-579)CGG>TGG	p.R193W	MYOC_uc010pmk.1_Missense_Mutation_p.R135W	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	193					anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GGCACAGCCCGAGCAGTGTCT	0.582000													48	261					0	0	1	0	0
SLC9A11	284525	broad.mit.edu	37	1	173556818	173556818	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:173556818G>A	uc001giz.2	-	5	932	c.509C>T	c.(508-510)TCA>TTA	p.S170L	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	170					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						AGTTTTTAGTGAATTCACAGA	0.299000													11	40					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175375845	175375845	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:175375845C>T	uc001gkp.1	-	1	87	c.6G>A	c.(4-6)GGG>GGA	p.G2G	TNR_uc009wwu.1_Silent_p.G2G|TNR_uc010pmz.1_Silent_p.G2G	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	2					axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CCCCATCTGCCCCCATCCTCT	0.532000													14	139					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563735	176563735	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:176563735G>A	uc001gkz.2	+	3	2159	c.995G>A	c.(994-996)GGA>GAA	p.G332E	PAPPA2_uc001gky.1_Missense_Mutation_p.G332E|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	332					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AAGGACAAGGGAAAGCGGGAT	0.562000													10	49					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176760588	176760588	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:176760588G>A	uc001gkz.2	+	19	6154	c.4990G>A	c.(4990-4992)GAG>AAG	p.E1664K	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1664	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAATTCTGTGGAGTACAAATG	0.423000													13	50					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	177001592	177001592	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:177001592C>T	uc001glc.2	-	3	1077	c.865G>A	c.(865-867)GGA>AGA	p.G289R	ASTN1_uc001glb.1_Missense_Mutation_p.G289R|ASTN1_uc001gld.1_Missense_Mutation_p.G289R|ASTN1_uc009wwx.1_Missense_Mutation_p.G289R|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	289					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						CCATCCCCACCTGGTGTGAGG	0.587000													25	153					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181702859	181702859	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:181702859C>T	uc001gow.2	+	21	3400	c.3235C>T	c.(3235-3237)CCC>TCC	p.P1079S	CACNA1E_uc009wxs.2_Missense_Mutation_p.P967S|CACNA1E_uc001gox.1_Missense_Mutation_p.P305S|CACNA1E_uc009wxt.2_Missense_Mutation_p.P305S	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1079	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CGACGTGGACCCCTTGGTGGA	0.627000													7	27					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276033	186276033	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:186276033G>A	uc001gru.3	+	7	1233	c.1182G>A	c.(1180-1182)AAG>AAA	p.K394K	PRG4_uc001grt.3_Silent_p.K353K|PRG4_uc009wyl.2_Silent_p.K301K|PRG4_uc009wym.2_Silent_p.K260K|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	394	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|7.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCACTCCCAAGGAGCCTGCAC	0.642000													17	83					0	0	1	0	0
FAM5C	339479	broad.mit.edu	37	1	190067966	190067966	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:190067966G>A	uc001gse.1	-	8	1715	c.1483C>T	c.(1483-1485)CTC>TTC	p.L495F	FAM5C_uc010pot.1_Missense_Mutation_p.L393F	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	495						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TTCATCTCGAGATCTTGCAGG	0.498000													37	181					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192544995	192544995	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:192544995G>A	uc001gsi.1	+	1	139	c.73G>A	c.(73-75)GAA>AAA	p.E25K	RGS1_uc010pou.1_Missense_Mutation_p.E25K	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	25					immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				TAACCCAAAGGAATTGAAAGG	0.418000													7	33					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197446814	197446814	+	Silent	SNP	C	T	T	rs142057392		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:197446814C>T	uc001gtz.2	+	12	4161	c.4026C>T	c.(4024-4026)TCC>TCT	p.S1342S	CRB1_uc010poz.1_Silent_p.S1318S|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.S1230S|CRB1_uc010ppb.1_Silent_p.S806S|CRB1_uc010ppd.1_Silent_p.S823S	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	1342	Extracellular (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ACTTGATCTCCGACATTTTCA	0.433000													7	37					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198721378	198721378	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:198721378G>A	uc001gur.1	+	30	3382	c.3202G>A	c.(3202-3204)GAA>AAA	p.E1068K	PTPRC_uc001gus.1_Missense_Mutation_p.E1020K|PTPRC_uc001gut.1_Missense_Mutation_p.E907K	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1068	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						TTTTATCTAGGAAATCTGTGC	0.383000													6	25					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201031145	201031145	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:201031145C>T	uc001gvv.2	-	24	3207	c.2980G>A	c.(2980-2982)GAC>AAC	p.D994N		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	994	III.|Extracellular (Potential).|Dihydropyridine binding (By similarity).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AAGTGGAAGTCGCTGTGTACC	0.602000													13	47					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201294249	201294249	+	Missense_Mutation	SNP	G	A	A	rs139909774		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:201294249G>A	uc001gwd.2	+	12	2329	c.2078G>A	c.(2077-2079)CGA>CAA	p.R693Q	PKP1_uc001gwe.2_Missense_Mutation_p.R672Q|PKP1_uc009wzm.2_Missense_Mutation_p.R280Q	NM_000299	NP_000290	Q13835	PKP1_HUMAN	plakophilin 1 isoform 1b	693	ARM 9.				cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			ovary(2)	2						AACCTGTGCCGAAGCAGGTGG	0.612000													42	166					0	0	1	0	0
MYBPH	4608	broad.mit.edu	37	1	203140547	203140547	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:203140547G>A	uc001gzh.1	-	5	816	c.757C>T	c.(757-759)CTG>TTG	p.L253L	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	253	Ig-like C2-type 1.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		TTGGCCTCCAGGTCTTCCACG	0.627000													12	51					0	0	1	0	0
REN	5972	broad.mit.edu	37	1	204129756	204129756	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:204129756C>T	uc001haq.2	-	4	468	c.424G>A	c.(424-426)GGA>AGA	p.G142R		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	142					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AGTTCTGTTCCATTGTGCTTG	0.562000													14	102					0	0	1	0	0
PM20D1	148811	broad.mit.edu	37	1	205813319	205813319	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:205813319G>A	uc001hdj.2	-	5	648	c.603C>T	c.(601-603)ATC>ATT	p.I201I	PM20D1_uc009xbr.2_RNA	NM_152491	NP_689704	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1 precursor	201						extracellular region	metal ion binding|peptidase activity			skin(1)	1	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			GCAGGGCTGAGATCCTCTGAG	0.527000													18	135					0	0	1	0	0
FCAMR	83953	broad.mit.edu	37	1	207131962	207131962	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:207131962G>A	uc001hfa.3	-	8	2133	c.1633C>T	c.(1633-1635)CAA>TAA	p.Q545*	FCAMR_uc001hfb.2_3'UTR|FCAMR_uc009xca.1_3'UTR|FCAMR_uc001hfc.2_Nonsense_Mutation_p.Q520*	NM_001122980	NP_001116452	Q8WWV6	FCAMR_HUMAN	Fc receptor, IgA, IgM, high affinity isoform 2	500	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						TGGTCTGCTTGGGGGTTCACT	0.547000													24	112					0	0	1	0	0
ANGEL2	90806	broad.mit.edu	37	1	213186685	213186685	+	Silent	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:213186685A>G	uc001hjz.2	-	2	290	c.135T>C	c.(133-135)TGT>TGC	p.C45C	ANGEL2_uc010pto.1_Intron|ANGEL2_uc010ptp.1_Intron|ANGEL2_uc001hka.2_Intron|ANGEL2_uc010ptq.1_Intron|ANGEL2_uc001hkb.2_Silent_p.C23C	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	45											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		TGTTCCAGCAACACCTTTGCA	0.448000													31	143					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214813533	214813533	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:214813533C>T	uc001hkm.2	+	12	2026	c.1852C>T	c.(1852-1854)CTG>TTG	p.L618L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	618	Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGAGAAAACTCTGTTTTCTTG	0.318000													4	27					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216138719	216138719	+	Missense_Mutation	SNP	G	A	A	rs111033508	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:216138719G>A	uc001hku.1	-	37	7447	c.7060C>T	c.(7060-7062)CGC>TGC	p.R2354C		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2354	Extracellular (Potential).|Fibronectin type-III 10.		R -> H (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCATTAGGGCGAAAAGGTGCT	0.408000										HNSCC(13;0.011)			12	92					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216497030	216497030	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:216497030G>A	uc001hku.1	-	8	1723	c.1336C>T	c.(1336-1338)CCA>TCA	p.P446S	USH2A_uc001hkv.2_Missense_Mutation_p.P446S	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	446	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CGGGAATATGGAGTAAAACTG	0.343000										HNSCC(13;0.011)			7	66					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220170408	220170408	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:220170408T>G	uc001hly.1	-	18	2728	c.2458A>C	c.(2458-2460)ATT>CTT	p.I820L	EPRS_uc010puf.1_Missense_Mutation_p.I571L|EPRS_uc001hlz.1_Missense_Mutation_p.I827L	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	820	3 X 57 AA approximate repeats.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	CTTTCCAGAATACTTGCTGAG	0.393000													12	69					0	0	1	0	0
PSEN2	5664	broad.mit.edu	37	1	227076736	227076736	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:227076736C>T	uc009xeo.1	+	8	1200	c.773C>T	c.(772-774)GCC>GTC	p.A258V	PSEN2_uc009xep.1_Missense_Mutation_p.A258V|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	258	Helical; (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				ATCCTGGGCGCCATCTCTGTG	0.622000													7	28					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228520913	228520913	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:228520913G>A	uc009xez.1	+	58	15789	c.15745G>A	c.(15745-15747)GGA>AGA	p.G5249R	OBSCN_uc001hsn.2_Missense_Mutation_p.G5249R|OBSCN_uc001hsr.1_5'Flank	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5249					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGAGCAGGAGGGAACAGAGTC	0.652000													3	11					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229771476	229771476	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:229771476C>T	uc001hts.1	+	4	1252	c.1116C>T	c.(1114-1116)ATC>ATT	p.I372I	URB2_uc009xfd.1_Silent_p.I372I	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	372						nucleolus				central_nervous_system(2)|ovary(1)	3						ACAACAATATCTACAACATCG	0.517000													6	48					0	0	1	0	0
DISC1	27185	broad.mit.edu	37	1	231830283	231830283	+	Missense_Mutation	SNP	G	A	A	rs149702548		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:231830283G>A	uc001huz.2	+	2	832	c.779G>A	c.(778-780)CGA>CAA	p.R260Q	TSNAX-DISC1_uc010pwe.1_Missense_Mutation_p.R215Q|TSNAX-DISC1_uc010pwf.1_Missense_Mutation_p.R215Q|TSNAX-DISC1_uc010pwg.1_Missense_Mutation_p.R249Q|TSNAX-DISC1_uc010pwh.1_Missense_Mutation_p.R215Q|TSNAX-DISC1_uc010pwi.1_Missense_Mutation_p.R215Q|TSNAX-DISC1_uc010pwj.1_Missense_Mutation_p.R249Q|TSNAX-DISC1_uc010pwk.1_Missense_Mutation_p.R249Q|TSNAX-DISC1_uc010pwl.1_RNA|DISC1_uc010pwo.1_Missense_Mutation_p.R260Q|DISC1_uc010pwp.1_Missense_Mutation_p.R260Q|DISC1_uc010pwq.1_Missense_Mutation_p.R260Q|DISC1_uc010pwr.1_Missense_Mutation_p.R260Q|DISC1_uc010pws.1_Missense_Mutation_p.R260Q|DISC1_uc010pwt.1_Missense_Mutation_p.R260Q|DISC1_uc010pwu.1_Intron|DISC1_uc010pwv.1_RNA|DISC1_uc010pww.1_Missense_Mutation_p.R260Q|DISC1_uc010pwx.1_RNA|DISC1_uc010pwy.1_RNA|DISC1_uc010pwz.1_RNA|DISC1_uc010pxa.1_RNA|DISC1_uc001huy.2_Missense_Mutation_p.R260Q|DISC1_uc010pxb.1_Missense_Mutation_p.R260Q|DISC1_uc010pxc.1_Missense_Mutation_p.R260Q|DISC1_uc010pxd.1_5'UTR|DISC1_uc010pxe.1_Missense_Mutation_p.R260Q|DISC1_uc009xfr.2_Missense_Mutation_p.R215Q|DISC1_uc010pxf.1_Missense_Mutation_p.R260Q|DISC1_uc010pxg.1_Missense_Mutation_p.R260Q|DISC1_uc010pxh.1_Missense_Mutation_p.R260Q|DISC1_uc010pxi.1_RNA|DISC1_uc010pxj.1_5'UTR|DISC1_uc010pxk.1_RNA|DISC1_uc010pxl.1_RNA|DISC1_uc010pxm.1_Missense_Mutation_p.R260Q|DISC1_uc010pxn.1_5'UTR|DISC1_uc001hva.2_Missense_Mutation_p.R260Q|DISC1_uc010pwm.1_Missense_Mutation_p.R260Q|DISC1_uc001hux.1_Missense_Mutation_p.R260Q|DISC1_uc001hvc.3_Missense_Mutation_p.R260Q|DISC1_uc010pwn.1_Missense_Mutation_p.R260Q	NM_018662	NP_061132	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1 isoform L	260	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			skin(1)	1		all_cancers(173;0.0208)|Prostate(94;0.0975)				GAGGACCCGCGATGTCTCTCT	0.627000													3	36					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233275475	233275475	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:233275475C>T	uc001hvl.2	-	20	3879	c.3644G>A	c.(3643-3645)CGG>CAG	p.R1215Q	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_RNA|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1215						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				ACCAAGTCTCCGGTGATTGCT	0.358000													3	8					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235336015	235336015	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:235336015G>A	uc001hwq.2	-	23	4227	c.3729C>T	c.(3727-3729)ATC>ATT	p.I1243I	ARID4B_uc001hwr.2_Silent_p.I1157I|ARID4B_uc001hwp.2_RNA	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	1243	Potential.			IR -> NQ (in Ref. 3; AAF23433 and 10; AAD41239).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			AATGTTTTCTGATTTCTTGAA	0.318000													4	20					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236890999	236890999	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:236890999C>T	uc001hyf.2	+	6	762	c.558C>T	c.(556-558)CTC>CTT	p.L186L	ACTN2_uc001hyg.2_5'UTR|ACTN2_uc009xgi.1_Silent_p.L186L	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	186	CH 2.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GCCTTGGACTCTGTGCCCTCA	0.542000													19	83					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237806680	237806680	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:237806680C>T	uc001hyl.1	+	48	7395	c.7275C>T	c.(7273-7275)TCC>TCT	p.S2425S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2425	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTTGAGATCCCTCATTCCCC	0.423000													12	109					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237843765	237843765	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:237843765C>T	uc001hyl.1	+	62	9025	c.8905C>T	c.(8905-8907)CCT>TCT	p.P2969S	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2969	Modulator (Potential).|Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTCGTTCTTCCTTTAATTGA	0.423000													3	13					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247150613	247150613	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:247150613G>A	uc009xgu.2	-	4	1349	c.1204C>T	c.(1204-1206)CAT>TAT	p.H402Y	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron|ZNF695_uc009xgt.1_Intron|ZNF695_uc001ibx.2_Intron|ZNF695_uc001iby.2_Intron	NM_020394	NP_065127	Q8IW36	ZN695_HUMAN	zinc finger protein SBZF3	402	C2H2-type 9.				regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TGCCCAGTATGAATTCTCTTA	0.388000													13	38					0	0	1	0	0
OR2B11	127623	broad.mit.edu	37	1	247614919	247614919	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:247614919C>T	uc010pyx.1	-	1	366	c.366G>A	c.(364-366)ATG>ATA	p.M122I		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	122	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGTCCAGGGCCATGGCGGCCA	0.612000													16	74					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769009	247769009	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:247769009G>A	uc010pyz.1	+	1	122	c.122G>A	c.(121-123)GGA>GAA	p.G41E		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ACCCTTGTGGGAAACTTCACC	0.448000													11	125					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875181	247875181	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:247875181G>A	uc001idj.1	-	1	877	c.877C>T	c.(877-879)CGT>TGT	p.R293C		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TCCTTATTACGAAGCGTATAG	0.438000													15	118					0	0	1	0	0
OR2L2	26246	broad.mit.edu	37	1	248202484	248202484	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:248202484G>A	uc001idw.2	+	1	1011	c.915G>A	c.(913-915)CAG>CAA	p.Q305Q	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AAGTGATTCAGAAAATCTTCT	0.433000													20	82					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263268	248263268	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:248263268G>A	uc001ids.2	+	3	928	c.591G>A	c.(589-591)ATG>ATA	p.M197I		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	197	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATGAATATATGGTTTTTGTAA	0.438000													17	65					0	0	1	0	0
OR2M1P	388762	broad.mit.edu	37	1	248285968	248285968	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:248285968C>T	uc001idy.1	+	1	531	c.531C>T	c.(529-531)CTC>CTT	p.L177L		NR_002141				RecName: Full=Olfactory receptor 2M5;												0						CCTCTCACCTCATGGTGGTGG	0.493000													24	159					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402361	248402361	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:248402361C>T	uc010pzh.1	+	1	131	c.131C>T	c.(130-132)TCC>TTC	p.S44F		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GAAAATATTTCCATGGTTCTC	0.478000													19	84					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402548	248402548	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:248402548C>T	uc010pzh.1	+	1	318	c.318C>T	c.(316-318)TCC>TCT	p.S106S		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCTATGTGTCCCTGCTTGGAG	0.458000													6	36					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248845151	248845151	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:248845151G>A	uc001ieu.1	-	1	455	c.455C>T	c.(454-456)TCC>TTC	p.S152F		NM_001004734	NP_001004734	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCTGCGTAGGAAAAGCAGCT	0.552000													8	44					0	0	1	0	0
MCM10	55388	broad.mit.edu	37	10	13217513	13217513	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:13217513C>T	uc001ima.2	+	6	700	c.599C>T	c.(598-600)CCC>CTC	p.P200L	MCM10_uc001imb.2_Missense_Mutation_p.P199L|MCM10_uc001imc.2_Missense_Mutation_p.P199L	NM_182751	NP_877428	Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	200					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TTTCTAGATCCCAAAAGCTCA	0.373000													18	61					0	0	1	0	0
PRPF18	8559	broad.mit.edu	37	10	13658471	13658471	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:13658471A>G	uc001imp.2	+	9	1014	c.866A>G	c.(865-867)CAT>CGT	p.H289R	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	289					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						GTTGGTATCCATGCCAGAACT	0.423000													8	72					0	0	1	0	0
FAM107B	83641	broad.mit.edu	37	10	14816561	14816561	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:14816561C>T	uc001ina.1	-	1	336	c.102G>A	c.(100-102)ACG>ACA	p.T34T	FAM107B_uc010qbu.1_RNA	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	Error:Variant_position_missing_in_Q9H098_after_alignment										breast(4)	4						CACTCTCCCTCGTATTCCCAA	0.542000													20	71					0	0	1	0	0
FAM23A	653567	broad.mit.edu	37	10	18060348	18060348	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:18060348C>T	uc009xjy.2	+	2	358	c.314C>T	c.(313-315)TCC>TTC	p.S105F	FAM23A_uc010qci.1_Missense_Mutation_p.S31F	NM_001098844	NP_001092314	Q5W0B7	TM236_HUMAN	hypothetical protein LOC653567	105	Helical; (Potential).					integral to membrane					0						CTCACCTTTTCCATAGCAGTG	0.403000													13	17					0	0	1	0	0
PLXDC2	84898	broad.mit.edu	37	10	20432305	20432305	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:20432305C>T	uc001iqg.1	+	5	1260	c.623C>T	c.(622-624)CCC>CTC	p.P208L	PLXDC2_uc001iqh.1_Missense_Mutation_p.P159L|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	208	Extracellular (Potential).					integral to membrane		p.P208L(1)		ovary(2)|central_nervous_system(1)|skin(1)	4						AATTTCGATCCCAGTGTATCC	0.358000													12	86					0	0	1	0	0
C10orf113	387638	broad.mit.edu	37	10	21414945	21414945	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:21414945C>T	uc001iqm.2	-	2	265	c.245G>A	c.(244-246)CGG>CAG	p.R82Q	NEBL_uc001iqk.2_Intron	NM_001010896	NP_001010896	Q5VZT2	CJ113_HUMAN	hypothetical protein LOC387638	92										ovary(3)|pancreas(1)	4						GCTGACTCTCCGCAGCCACCT	0.617000													18	69					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24832141	24832141	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:24832141G>A	uc001iru.3	+	19	4345	c.3942G>A	c.(3940-3942)ACG>ACA	p.T1314T	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Silent_p.T997T|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Silent_p.T150T	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1314					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AGCAAAATACGGATAAGTGTC	0.418000													22	66					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25464519	25464519	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:25464519C>T	uc001isj.2	+	1	230	c.170C>T	c.(169-171)TCC>TTC	p.S57F	LOC100128811_uc010qde.1_Intron	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	57	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GCCTCGGACTCCTCGGCTCCC	0.697000													7	32					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25839976	25839976	+	Silent	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:25839976T>C	uc001isj.2	+	6	1536	c.1476T>C	c.(1474-1476)TTT>TTC	p.F492F		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	492	Helical; Name=3; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TTCTCGGTTTTGCTACTGTTT	0.398000													23	93					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27687850	27687850	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:27687850C>T	uc001itu.2	-	4	1795	c.1677G>A	c.(1675-1677)TGG>TGA	p.W559*		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	559					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TAAATGAGGGCCATTTTGGGT	0.383000													11	56					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702693	27702693	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:27702693C>T	uc001itu.2	-	1	605	c.487G>A	c.(487-489)GAA>AAA	p.E163K		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	163					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TCTTCCTCTTCGTCCTTGGGT	0.662000													41	182					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30318367	30318367	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:30318367G>A	uc001iux.2	-	2	769	c.710C>T	c.(709-711)TCC>TTC	p.S237F	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.S99F|KIAA1462_uc009xle.1_Missense_Mutation_p.S237F	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	237										ovary(4)	4						GCTCTCGGGGGAAAGAACTCT	0.463000													25	136					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810433	31810433	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:31810433G>A	uc001ivs.3	+	7	2233	c.2170G>A	c.(2170-2172)GAG>AAG	p.E724K	ZEB1_uc001ivr.3_Missense_Mutation_p.E506K|ZEB1_uc010qee.1_Missense_Mutation_p.E506K|ZEB1_uc010qef.1_Missense_Mutation_p.E506K|ZEB1_uc009xlj.1_Missense_Mutation_p.E650K|ZEB1_uc010qeg.1_Missense_Mutation_p.E583K|ZEB1_uc009xlk.1_Missense_Mutation_p.E506K|ZEB1_uc001ivt.3_Missense_Mutation_p.E506K|ZEB1_uc001ivu.3_Missense_Mutation_p.E725K|ZEB1_uc001ivv.3_Missense_Mutation_p.E704K|ZEB1_uc010qeh.1_Missense_Mutation_p.E657K|ZEB1_uc009xlo.1_Missense_Mutation_p.E707K|ZEB1_uc009xlp.2_Missense_Mutation_p.E708K	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	724					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				GTACACAGCTGAGGGTGCACA	0.438000													5	58					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	32983862	32983862	+	Silent	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:32983862A>G	uc001iwn.3	+	6	794	c.321A>G	c.(319-321)TCA>TCG	p.S107S	C10orf68_uc001iwl.1_Silent_p.S115S|C10orf68_uc001iwm.1_Intron|C10orf68_uc010qei.1_Silent_p.S34S	NM_024688	NP_078964	Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	107										skin(2)|ovary(1)	3						ATTCAGTGTCAAAACTGGAAA	0.299000													8	40					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50121550	50121550	+	Silent	SNP	G	A	A	rs150055684		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:50121550G>A	uc001jhd.2	-	1	731	c.651C>T	c.(649-651)GCC>GCT	p.A217A	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Silent_p.A217A	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	217						cytoplasm				ovary(1)|pancreas(1)	2						GGTTGTCCCGGGCGTTTTGGC	0.493000													25	69					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531857	50531857	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:50531857G>A	uc010qgp.1	+	3	1606	c.1267G>A	c.(1267-1269)GAA>AAA	p.E423K		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	423											0						ACAGTTTTCAGAAAACAATGC	0.458000													17	67					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61432545	61432545	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:61432545G>A	uc010qig.1	-	3	772	c.323C>T	c.(322-324)TCC>TTC	p.S108F		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	108	Helical; (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3						AATGCCATAGGAAAAAAACAG	0.428000													9	34					0	0	1	0	0
SLC16A9	220963	broad.mit.edu	37	10	61444018	61444018	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:61444018C>T	uc010qig.1	-	2	481	c.32G>A	c.(31-33)TGG>TAG	p.W11*		NM_194298	NP_919274	Q7RTY1	MOT9_HUMAN	solute carrier family 16 (monocarboxylic acid	11	Extracellular (Potential).				urate metabolic process	integral to membrane|plasma membrane	symporter activity			skin(2)|ovary(1)	3						CACCCAGCCCCATCCACCGTC	0.438000													13	67					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61941146	61941146	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:61941146G>A	uc001jky.2	-	18	2317	c.2125C>T	c.(2125-2127)CGA>TGA	p.R709*	ANK3_uc010qih.1_Nonsense_Mutation_p.R692*|ANK3_uc001jkz.3_Nonsense_Mutation_p.R703*|ANK3_uc001jlb.1_Nonsense_Mutation_p.R238*|ANK3_uc001jlc.1_Nonsense_Mutation_p.R370*	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	709	ANK 20.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ACATTCACTCGATCTTCTTGA	0.522000													29	96					0	0	1	0	0
ANXA2P3	305	broad.mit.edu	37	10	66585799	66585799	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:66585799G>A	uc009xpm.1	+	1		c.515G>A				NR_001446				Human lipocortin (LIP) 2 pseudogene mRNA, complete cds-like region.												0						TCTGGAGAAGGACATTATTTC	0.443000													3	15					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940120	68940120	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:68940120G>A	uc009xpn.1	-	7	1125	c.1002C>T	c.(1000-1002)GCC>GCT	p.A334A	CTNNA3_uc001jmw.2_Silent_p.A334A|CTNNA3_uc001jmx.3_Silent_p.A334A|CTNNA3_uc009xpo.1_Silent_p.A194A|CTNNA3_uc001jna.2_Silent_p.A346A	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	334	Potential.				cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CCTGGCGAATGGCGTTGCATT	0.512000													13	37					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73046571	73046571	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:73046571G>A	uc001jro.2	+	5	1123	c.678G>A	c.(676-678)GTG>GTA	p.V226V	UNC5B_uc001jrp.2_Silent_p.V226V	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	226	Ig-like C2-type.|Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						ATACCTGCGTGGCCAAGAACA	0.632000													51	234					0	0	1	0	0
NUDT13	25961	broad.mit.edu	37	10	74884003	74884003	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:74884003G>A	uc001jtj.2	+	5	515	c.390G>A	c.(388-390)GAG>GAA	p.E130E	NUDT13_uc010qkc.1_Silent_p.E4E|NUDT13_uc010qkd.1_Intron|NUDT13_uc009xqw.2_RNA|NUDT13_uc001jtk.2_Silent_p.E130E|NUDT13_uc010qke.1_Intron|NUDT13_uc001jtl.2_Silent_p.E130E	NM_015901	NP_056985	Q86X67	NUD13_HUMAN	nudix-type motif 13	130							hydrolase activity|metal ion binding				0	Prostate(51;0.0119)					TGGAGACAGAGCTCAAGGGGT	0.423000													7	58					0	0	1	0	0
MYST4	23522	broad.mit.edu	37	10	76781945	76781945	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:76781945C>T	uc001jwn.1	+	16	3821	c.3328C>T	c.(3328-3330)CCC>TCC	p.P1110S	MYST4_uc001jwm.1_Missense_Mutation_p.P818S|MYST4_uc001jwo.1_Missense_Mutation_p.P818S|MYST4_uc001jwp.1_Missense_Mutation_p.P927S	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1110					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					TCAAAGCTCTCCCCCAAGATT	0.224000			T	CREBBP	AML						OREG0020273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	67					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96447648	96447648	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:96447648G>A	uc001kjv.3	+	2	616	c.290G>A	c.(289-291)AGA>AAA	p.R97K	CYP2C18_uc001kjw.3_Missense_Mutation_p.R97K|CYP2C19_uc009xus.1_5'Flank|CYP2C19_uc010qny.1_5'Flank	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	97					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TTTTCTGGAAGAGGAAGTTTT	0.443000													14	80					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96818161	96818161	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:96818161T>G	uc001kkb.2	-	5	845	c.750A>C	c.(748-750)GAA>GAC	p.E250D	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.E180D|CYP2C8_uc010qob.1_Missense_Mutation_p.E164D|CYP2C8_uc010qoc.1_Missense_Mutation_p.E148D|CYP2C8_uc010qod.1_Missense_Mutation_p.E164D	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	250					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	ATGCTTGGTGTTCTTTTACTT	0.373000													10	23					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96829157	96829157	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:96829157C>T	uc001kkb.2	-	1	98	c.3G>A	c.(1-3)ATG>ATA	p.M1I	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_5'UTR|CYP2C8_uc010qob.1_5'UTR|CYP2C8_uc010qoc.1_5'UTR|CYP2C8_uc010qod.1_5'UTR	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	1					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CAAAAGGTTCCATTGAAGCCT	0.448000													3	33					0	0	1	0	0
HPS1	3257	broad.mit.edu	37	10	100195400	100195400	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:100195400G>A	uc010qpf.1	-	4	493	c.247C>T	c.(247-249)CTT>TTT	p.L83F	HPS1_uc001kpi.1_Missense_Mutation_p.L83F|HPS1_uc001kpj.1_Missense_Mutation_p.L23F|HPS1_uc001kpk.1_Missense_Mutation_p.L83F|HPS1_uc009xwb.2_RNA|HPS1_uc010qph.1_Missense_Mutation_p.L83F|HPS1_uc001kpl.2_Missense_Mutation_p.L83F	NM_000195	NP_000186	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1 protein isoform a	83					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			skin(1)	1		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		ACCAGGTGAAGGACATACAGG	0.527000									Hermansky-Pudlak_syndrome				19	99					0	0	1	0	0
ENTPD7	57089	broad.mit.edu	37	10	101462315	101462315	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:101462315G>A	uc001kqa.3	+	12	1646	c.1468G>A	c.(1468-1470)GGA>AGA	p.G490R	ENTPD7_uc009xwl.2_Missense_Mutation_p.G492R	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	490	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		CTTACATGAAGGATTCCACTT	0.393000													9	8					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101569906	101569906	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:101569906G>A	uc001kqf.2	+	14	1970	c.1831G>A	c.(1831-1833)GAG>AAG	p.E611K		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	611	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TGTTTCCACAGAGCGGCTAGA	0.433000													11	46					0	0	1	0	0
HABP2	3026	broad.mit.edu	37	10	115338440	115338440	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:115338440G>A	uc001lai.3	+	7	726	c.623G>A	c.(622-624)AGG>AAG	p.R208K	HABP2_uc010qrz.1_RNA|HABP2_uc010qry.1_3'UTR	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	208	Kringle.				cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		AAAATGAATAGGACAGTCAAC	0.493000													19	85					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123892183	123892183	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:123892183C>T	uc001lfv.2	+	6	5993	c.5633C>T	c.(5632-5634)ACC>ATC	p.T1878I	TACC2_uc001lfw.2_Missense_Mutation_p.T69I|TACC2_uc009xzx.2_Missense_Mutation_p.T1878I|TACC2_uc010qtv.1_Missense_Mutation_p.T1927I|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1878						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GAAAGCCCAACCTTAGCTGCC	0.557000													27	102					0	0	1	0	0
BTBD16	118663	broad.mit.edu	37	10	124097543	124097543	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr10:124097543C>T	uc001lgc.1	+	16	1715	c.1464C>T	c.(1462-1464)ATC>ATT	p.I488I	BTBD16_uc001lgd.1_Silent_p.I487I	NM_144587	NP_653188	Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	488										skin(1)	1		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CCTTGAAAATCCAAACTGTGG	0.418000													10	18					0	0	1	0	0
PKP3	11187	broad.mit.edu	37	11	399129	399129	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:399129G>A	uc001lpc.2	+	5	1282	c.1206G>A	c.(1204-1206)GAG>GAA	p.E402E		NM_007183	NP_009114	Q9Y446	PKP3_HUMAN	plakophilin 3	402	ARM 3.				cell adhesion	desmosome|nucleus	binding			skin(1)	1		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGTGGAGGAGAACGGGATCT	0.517000													3	37					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1262886	1262886	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:1262886G>A	uc009ycr.1	+	47	6981	c.6855G>A	c.(6853-6855)AGG>AGA	p.R2285R	MUC5B_uc001ltb.2_Silent_p.R1595R	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1592	7 X Cys-rich subdomain repeats.|Cys-rich subdomain 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACAACTACAGGATCCGGGTCC	0.637000													5	19					0	0	1	0	0
TSSC4	10078	broad.mit.edu	37	11	2424761	2424761	+	Nonsense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:2424761G>T	uc001lwj.2	+	4	1259	c.898G>T	c.(898-900)GAA>TAA	p.E300*	TSSC4_uc001lwi.2_Nonsense_Mutation_p.E236*|TSSC4_uc001lwk.2_Nonsense_Mutation_p.E300*|TSSC4_uc001lwl.2_Nonsense_Mutation_p.E300*	NM_005706	NP_005697	Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	300											0		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCGCCGGTGGAAACTGTTGG	0.637000													5	44					5.18039e-06	5.21186e-06	1	1	0
OR52B4	143496	broad.mit.edu	37	11	4389043	4389043	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:4389043G>A	uc010qye.1	-	1	483	c.483C>T	c.(481-483)ATC>ATT	p.I161I		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	161	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAAGAAATATGATAGGGAAAA	0.358000													8	21					0	0	1	0	0
OR51D1	390038	broad.mit.edu	37	11	4661698	4661698	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:4661698C>T	uc010qyk.1	+	1	678	c.678C>T	c.(676-678)TTC>TTT	p.F226F		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	226	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACTCTCTCTTCATTGGCTTCT	0.498000													13	62					0	0	1	0	0
OR51F1	256892	broad.mit.edu	37	11	4790821	4790821	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:4790821G>A	uc010qyl.1	-	1	327	c.327C>T	c.(325-327)TTC>TTT	p.F109F		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	109						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCATAAAAGTGAATCCATGAA	0.428000													7	36					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4843021	4843021	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:4843021C>T	uc010qyn.1	+	1	406	c.406C>T	c.(406-408)CGT>TGT	p.R136C		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGCCTTTGATCGTTTTGTGGC	0.463000													26	107					0	0	1	0	0
MMP26	56547	broad.mit.edu	37	11	5009503	5009503	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5009503C>T	uc001lzv.2	+	1	80	c.62C>T	c.(61-63)CCC>CTC	p.P21L		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	21					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTTCCAGTGCCCCCTGCTGCA	0.488000													23	136					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153029	5153029	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5153029G>A	uc010qyx.1	-	1	844	c.844C>T	c.(844-846)CTT>TTT	p.L282F		NM_001005160	NP_001005160	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|lung(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		AACAGGTAAAGATTTGACAAG	0.383000													16	64					0	0	1	0	0
HBG1	3047	broad.mit.edu	37	11	5270642	5270642	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5270642C>T	uc001mah.1	-	2	324	c.271G>A	c.(271-273)GAA>AAA	p.E91K	HBG2_uc001mai.1_Intron	NM_000559	NP_000550	P69891	HBG1_HUMAN	A-gamma globin	91					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity|protein binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTGCAGTTCACTCAGCTGG	0.517000													9	57					0	0	1	0	0
HBG2	3048	broad.mit.edu	37	11	5275566	5275566	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5275566C>T	uc001mai.1	-	2	708	c.271G>A	c.(271-273)GAA>AAA	p.E91K	HBG2_uc001mak.1_RNA|HBG2_uc001maj.1_Missense_Mutation_p.E91K	NM_000559	NP_000550	P69892	HBG2_HUMAN	A-gamma globin	91					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGTGCAGTTCACTCAGCTGG	0.507000													8	139					0	0	1	0	0
OR51B4	79339	broad.mit.edu	37	11	5322369	5322369	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5322369G>A	uc010qza.1	-	1	808	c.808C>T	c.(808-810)CCC>TCC	p.P270S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGTAATGGGGACCACATGA	0.423000													5	56					0	0	1	0	0
OR51B2	79345	broad.mit.edu	37	11	5345040	5345040	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5345040G>A	uc001mao.1	-	1	543	c.488C>T	c.(487-489)TCA>TTA	p.S163L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	163	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATATGAAAATGAAAAAAGACG	0.398000													8	45					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364072	5364072	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5364072G>A	uc001map.1	-	1	683	c.683C>T	c.(682-684)TCC>TTC	p.S228F	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	228	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCCTCTCTGGAGGCAATGCT	0.443000													14	95					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566169	5566169	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5566169G>A	uc010qzh.1	-	1	585	c.585C>T	c.(583-585)CTC>CTT	p.L195L	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGCACAGGCGAGCTGGGCAA	0.488000													15	66					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566262	5566262	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5566262G>A	uc010qzh.1	-	1	492	c.492C>T	c.(490-492)ATC>ATT	p.I164I	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	164	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CATCTGGCAGGATGATGCAGA	0.493000													5	50					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566399	5566399	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5566399C>T	uc010qzh.1	-	1	355	c.355G>A	c.(355-357)GAT>AAT	p.D119N	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGCTGAATCCAGGACAAAG	0.448000													16	78					0	0	1	0	0
OR52N4	390072	broad.mit.edu	37	11	5776340	5776340	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5776340C>T	uc001mbu.2	+	1	418	c.370C>T	c.(370-372)CGC>TGC	p.R124C	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		GGCCCTGGATCGCTATGTGGC	0.493000													15	75					0	0	1	0	0
OR52E6	390078	broad.mit.edu	37	11	5862783	5862783	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:5862783G>A	uc010qzq.1	-	1	345	c.345C>T	c.(343-345)ATC>ATT	p.I115I	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCACCAATACGATGCTCTCCA	0.448000													19	151					0	0	1	0	0
OR56A4	120793	broad.mit.edu	37	11	6024114	6024114	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:6024114G>A	uc010qzv.1	-	1	265	c.265C>T	c.(265-267)CTC>TTC	p.L89F		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGAGGAAGAGAAGGCTGAGG	0.592000													9	44					0	0	1	0	0
OR52B2	255725	broad.mit.edu	37	11	6190872	6190872	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:6190872G>A	uc010qzy.1	-	1	685	c.685C>T	c.(685-687)CGT>TGT	p.R229C		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGGCAAACGAAACACTGCT	0.478000													6	32					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6261005	6261005	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:6261005G>A	uc001mco.2	+	3	363	c.256G>A	c.(256-258)GTG>ATG	p.V86M	CNGA4_uc010raa.1_Missense_Mutation_p.V46M|CNGA4_uc001mcn.2_Missense_Mutation_p.V46M	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	86	Helical; Name=H2; (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGACATGGTGGTGCGCTTCCA	0.542000													4	31					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6261526	6261526	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:6261526C>T	uc001mco.2	+	4	609	c.502C>T	c.(502-504)CGC>TGC	p.R168C	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.R128C	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	168	Extracellular (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAATGCCTTTCGCATTGCCAA	0.582000													23	94					0	0	1	0	0
OR2AG2	338755	broad.mit.edu	37	11	6790141	6790141	+	Silent	SNP	C	T	T	rs150134059		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:6790141C>T	uc001meq.1	-	1	48	c.48G>A	c.(46-48)GGG>GGA	p.G16G		NM_001004490	NP_001004490	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CATTCAGAATCCCCACCAAGA	0.463000													10	47					0	0	1	0	0
OR10A4	283297	broad.mit.edu	37	11	6897881	6897881	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:6897881G>A	uc010rat.1	+	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCAGAAGAATGATGTGGGAAA	0.408000													25	92					0	0	1	0	0
C11orf17	56672	broad.mit.edu	37	11	8933051	8933051	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:8933051C>T	uc001mgx.2	+	2	131	c.55C>T	c.(55-57)CAG>TAG	p.Q19*	ST5_uc001mgv.2_5'Flank|C11orf17_uc001mgz.2_Nonsense_Mutation_p.Q19*|C11orf17_uc001mgy.2_Nonsense_Mutation_p.Q19*|C11orf17_uc010rbr.1_Nonsense_Mutation_p.Q19*|C11orf17_uc010rbs.1_Nonsense_Mutation_p.Q19*|C11orf17_uc001mha.2_Nonsense_Mutation_p.Q19*	NM_020642	NP_065693	Q9NQ31	AKIP1_HUMAN	chromosome 11 open reading frame 17	19						nucleus	protein binding				0				Epithelial(150;5.08e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0243)		ACGTTCCCTGCAGCGTTCAGC	0.642000													8	22					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	10015506	10015506	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:10015506G>A	uc001mib.2	-	10	1153	c.1015C>T	c.(1015-1017)CCT>TCT	p.P339S	SBF2_uc001mif.3_Missense_Mutation_p.P95S	NM_030962	NP_112224	Q86WG5	MTMRD_HUMAN	SET binding factor 2	339					myelination	cytoplasm|membrane	phosphatase activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		CGTGGAGGAGGAAAAGCATGA	0.294000													5	47					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10515084	10515084	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:10515084C>T	uc001mio.1	+	7	1463	c.1128C>T	c.(1126-1128)GTC>GTT	p.V376V	AMPD3_uc010rbz.1_Silent_p.V217V|AMPD3_uc001min.1_Silent_p.V385V|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Silent_p.V383V|AMPD3_uc009yfy.2_Silent_p.V376V	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	376					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CACTGGATGTCCACGCGGTGA	0.637000													11	45					0	0	1	0	0
GALNTL4	374378	broad.mit.edu	37	11	11348663	11348663	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:11348663G>A	uc001mjo.2	-	9	1903	c.1482C>T	c.(1480-1482)ATC>ATT	p.I494I		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	494	Lumenal (Potential).|Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		AGATGTACATGATGGGGACAT	0.512000													20	86					0	0	1	0	0
GALNTL4	374378	broad.mit.edu	37	11	11400710	11400711	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:11400710_11400711GG>AA	uc001mjo.2	-	4	1117_1118	c.696_697CC>TT	c.(694-699)ATCCGC>ATTTGC	p.R233C		NM_198516	NP_940918	Q6P9A2	GLTL4_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	233	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0				all cancers(16;3.67e-05)|Epithelial(150;0.000184)		ACCCTGGAGCGGATGAGGCCTT	0.584000													4	46					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11976597	11976597	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:11976597C>T	uc001mjs.2	+	27	4542	c.3779C>T	c.(3778-3780)CCC>CTC	p.P1260L	USP47_uc001mjr.2_Missense_Mutation_p.P1192L|USP47_uc009ygi.2_Missense_Mutation_p.P62L	NM_017944	NP_060414	Q96K76	UBP47_HUMAN	ubiquitin specific protease 47	1280					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			ovary(1)|skin(1)	2				Epithelial(150;0.000339)		GGAACATTTCCCTGTGATATT	0.388000													11	54					0	0	1	0	0
DKK3	27122	broad.mit.edu	37	11	12029959	12029959	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:12029959C>T	uc001mju.2	-	1	228	c.171G>A	c.(169-171)CTG>CTA	p.L57L	DKK3_uc010rcf.1_Silent_p.L57L|DKK3_uc001mjv.2_Silent_p.L57L|DKK3_uc001mjw.2_Silent_p.L57L|DKK3_uc010rcg.1_Silent_p.L57L|DKK3_uc001mjx.2_Silent_p.L57L	NM_001018057	NP_001018067	Q9UBP4	DKK3_HUMAN	dickkopf homolog 3 precursor	57	Potential.				adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space				breast(1)	1				Epithelial(150;0.000502)		TGTCCTCCATCAGTTCCTCAA	0.672000													7	28					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15197503	15197503	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:15197503C>T	uc001mly.2	+	3	460	c.414C>T	c.(412-414)ATC>ATT	p.I138I	INSC_uc001mlz.2_Silent_p.I91I|INSC_uc001mma.2_Silent_p.I91I|INSC_uc010rcs.1_Silent_p.I91I|INSC_uc001mmb.2_Silent_p.I91I|INSC_uc001mmc.2_Silent_p.I91I	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	138					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						TGCGCAGGATCGGGCAGAAGC	0.652000													6	38					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16847920	16847920	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:16847920G>A	uc001mmo.2	-	10	1105	c.1090C>T	c.(1090-1092)CCG>TCG	p.P364S	PLEKHA7_uc010rcu.1_Missense_Mutation_p.P364S|PLEKHA7_uc001mmn.2_Missense_Mutation_p.P72S	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	364					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						GGCGAGTACGGAGACCTGGCC	0.602000													7	66					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16848076	16848076	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:16848076C>T	uc001mmo.2	-	10	949	c.934G>A	c.(934-936)GAA>AAA	p.E312K	PLEKHA7_uc010rcu.1_Missense_Mutation_p.E312K|PLEKHA7_uc001mmn.2_Missense_Mutation_p.E20K	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	312					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						CGGCCACATTCGTGACAGGAC	0.522000													23	149					0	0	1	0	0
C11orf46	120534	broad.mit.edu	37	11	30352784	30352784	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:30352784G>A	uc001mso.1	+	2	453	c.289G>A	c.(289-291)GAT>AAT	p.D97N		NM_152316	NP_689529	Q8N8R7	CK046_HUMAN	hypothetical protein LOC120534	97											0						TGACTTAGATGATGCCACTTT	0.358000													19	86					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137701	40137701	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:40137701G>A	uc001mxa.1	-	2	2106	c.142C>T	c.(142-144)CCT>TCT	p.P48S	LRRC4C_uc001mxc.1_Missense_Mutation_p.P44S|LRRC4C_uc001mxd.1_Missense_Mutation_p.P44S|LRRC4C_uc001mxb.1_Missense_Mutation_p.P44S	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	48	LRRNT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				CACACAGAAGGGCAGGTCTGA	0.562000													4	19					0	0	1	0	0
PRDM11	56981	broad.mit.edu	37	11	45204596	45204596	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:45204596C>T	uc001myo.2	+	5	759	c.510C>T	c.(508-510)ATC>ATT	p.I170I		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	170	SET.									upper_aerodigestive_tract(1)	1						ACGAGGTCATCCCCAAGGGCC	0.602000											OREG0020926	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	42					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46726695	46726695	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:46726695C>T	uc001nde.1	+	5	1675	c.1445C>T	c.(1444-1446)TCC>TTC	p.S482F	ZNF408_uc010rgw.1_Missense_Mutation_p.S474F	NM_024741	NP_079017	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	482	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding				0						AACCAGGGCTCCCTGCGGAAC	0.672000													24	91					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46765767	46765767	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:46765767G>A	uc001ndi.1	-	44	6015	c.5905C>T	c.(5905-5907)CCT>TCT	p.P1969S	CKAP5_uc009ylg.1_Missense_Mutation_p.P1862S|CKAP5_uc001ndj.1_Missense_Mutation_p.P1909S|CKAP5_uc001ndh.1_Missense_Mutation_p.P898S	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1969					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						GCGACAGTAGGAACTGCTGGT	0.517000													23	66					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48267003	48267003	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:48267003G>A	uc001ngs.1	+	1	348	c.348G>A	c.(346-348)GTG>GTA	p.V116V		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	116	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCACTATGTGGCCATCTGCA	0.507000													12	66					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347056	48347056	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:48347056C>T	uc010rhv.1	+	1	564	c.564C>T	c.(562-564)GTC>GTT	p.V188V		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCCTCCTGGTCCTTTGGTTGC	0.517000													17	72					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135500	55135500	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:55135500G>A	uc010rif.1	+	1	141	c.141G>A	c.(139-141)CAG>CAA	p.Q47Q		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	47	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGCTCACACAGAACCCTGAGG	0.428000													6	21					0	0	1	0	0
OR5L2	26338	broad.mit.edu	37	11	55595228	55595228	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:55595228C>T	uc001nhy.1	+	1	534	c.534C>T	c.(532-534)TTC>TTT	p.F178F		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				ACCACTTCTTCTGTGATCTAC	0.463000										HNSCC(27;0.073)			37	177					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681515	55681515	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:55681515G>A	uc010rir.1	-	1	544	c.544C>T	c.(544-546)CCT>TCT	p.P182S		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAGAGAGGAGGGATATCACAG	0.403000													18	99					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872796	55872796	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:55872796C>T	uc010riy.1	+	1	278	c.278C>T	c.(277-279)TCC>TTC	p.S93F		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					AACTATATTTCCTTTACGGGC	0.428000										HNSCC(53;0.14)			51	364					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873194	55873194	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:55873194C>T	uc010riy.1	+	1	676	c.676C>T	c.(676-678)CTG>TTG	p.L226L		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CTTTACCATCCTGAAAATTAA	0.383000										HNSCC(53;0.14)			15	77					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237223	56237223	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:56237223C>T	uc010rjk.1	-	1	751	c.751G>A	c.(751-753)GGT>AGT	p.G251S		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATCAGAGTACCATAGAATATA	0.488000													3	29					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409485	56409485	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:56409485C>T	uc001njb.1	-	1	431	c.431G>A	c.(430-432)GGG>GAG	p.G144E		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						GCAAATTCTCCCAGACACGAG	0.493000													13	73					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510337	56510337	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:56510337C>T	uc010rjo.1	-	1	951	c.951G>A	c.(949-951)AGG>AGA	p.R317R		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	317	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GTGTTGCTTTCCTGAAGGCCT	0.393000													10	71					0	0	1	0	0
OR9G4	283189	broad.mit.edu	37	11	56510965	56510965	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:56510965G>A	uc010rjo.1	-	1	323	c.323C>T	c.(322-324)TCC>TTC	p.S108F		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	108	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						TCCAGCCAAGGAAATGCGCTT	0.458000													24	110					0	0	1	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799099	57799099	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:57799099C>T	uc010rjz.1	+	1	675	c.675C>T	c.(673-675)ATC>ATT	p.I225I	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				ATGGCAACATCGTCTGGACAC	0.557000													19	63					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57971194	57971194	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:57971194C>G	uc010rkb.1	-	1	460	c.460G>C	c.(460-462)GGC>CGC	p.G154R		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				AGCAAAGTGCCGAACCTGGCC	0.483000													20	127					0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57983187	57983187	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:57983187C>T	uc010rkc.1	+	1	971	c.971C>T	c.(970-972)TCC>TTC	p.S324F		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	324	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				AAAATTTCTTCCCTTTGATGC	0.413000													16	113					0	0	1	0	0
OR10W1	81341	broad.mit.edu	37	11	58035226	58035226	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:58035226G>A	uc001nmq.1	-	1	507	c.105C>T	c.(103-105)CTC>CTT	p.L35L		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				ACACCACAATGAGAATGTTCC	0.473000													14	62					0	0	1	0	0
MS4A8B	83661	broad.mit.edu	37	11	60482845	60482845	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:60482845C>T	uc001npv.2	+	7	914	c.711C>T	c.(709-711)ACC>ACT	p.T237T		NM_031457	NP_113645	Q9BY19	M4A8B_HUMAN	membrane-spanning 4-domains, subfamily A, member	237	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						AACCGGTGACCTCACCACCAA	0.483000													6	47					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60635114	60635114	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:60635114G>A	uc001nqd.2	+	1	100	c.80G>A	c.(79-81)TGG>TAG	p.W27*	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	27	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						CTGGGTAGGTGGCTCCAGCCC	0.667000													7	41					0	0	1	0	0
DAGLA	747	broad.mit.edu	37	11	61504698	61504698	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:61504698C>T	uc001nsa.2	+	14	1527	c.1416C>T	c.(1414-1416)TCC>TCT	p.S472S		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	472	Cytoplasmic (Potential).	Charge relay system (By similarity).			cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		TGGGCCACTCCCTGGGCGCGG	0.652000													43	236					0	0	1	0	0
SLC3A2	6520	broad.mit.edu	37	11	62650391	62650391	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:62650391A>C	uc001nwd.2	+	6	1137	c.913A>C	c.(913-915)ATT>CTT	p.I305L	SLC3A2_uc001nwb.2_Missense_Mutation_p.I336L|SLC3A2_uc001nwc.2_Missense_Mutation_p.I306L|SLC3A2_uc001nwe.2_Missense_Mutation_p.I274L|SLC3A2_uc001nwf.2_Missense_Mutation_p.I243L|SLC3A2_uc001nwg.2_Missense_Mutation_p.I204L|SLC3A2_uc010rml.1_RNA	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	305	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						CATCCGTGTCATTCTGGACCT	0.483000													22	106					0	0	1	0	0
SLC22A24	283238	broad.mit.edu	37	11	62911041	62911041	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:62911041C>T	uc009yop.2	-	1	653	c.211G>A	c.(211-213)GAC>AAC	p.D71N		NM_001136506	NP_001129978			solute carrier family 22, member 24												0						CTCAGGAGGTCATCCTTGCTG	0.557000													4	26					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62951237	62951237	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:62951237C>T	uc001nwr.1	-	5	883	c.883G>A	c.(883-885)GGC>AGC	p.G295S	SLC22A10_uc010rmo.1_Intron|SLC22A25_uc009yoq.1_RNA|SLC22A25_uc001nws.1_RNA|SLC22A25_uc001nwt.1_Missense_Mutation_p.G295S	NM_199352	NP_955384	Q6T423	S22AP_HUMAN	putative UST1-like organic anion transporter	295	Cytoplasmic (Potential).				transmembrane transport	integral to membrane				ovary(3)|skin(1)	4						TCCTTTAAGCCCTCTTCTGGT	0.478000													19	88					0	0	1	0	0
FLRT1	23769	broad.mit.edu	37	11	63884924	63884924	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:63884924G>A	uc001nyi.1	+	2	1526	c.1185G>A	c.(1183-1185)ACG>ACA	p.T395T	MACROD1_uc001nyh.2_Intron	NM_013280	NP_037412	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein	367	Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity				0						CCAAGACCACGGCCAGCAACC	0.642000													6	32					0	0	1	0	0
NUDT22	84304	broad.mit.edu	37	11	63996739	63996739	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:63996739C>T	uc001nyp.3	+	4	780	c.600C>T	c.(598-600)ACC>ACT	p.T200T	NUDT22_uc009ype.2_Silent_p.T200T|NUDT22_uc001nyq.3_Silent_p.T167T|NUDT22_uc010rng.1_RNA|uc001nyr.1_3'UTR|DNAJC4_uc001nys.2_5'Flank|DNAJC4_uc001nyt.2_5'Flank|DNAJC4_uc001nyu.2_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety	200	Nudix hydrolase.						hydrolase activity				0						CGCTGCTCACCCTGAGCCAGC	0.617000													3	14					0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	66000511	66000511	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:66000511C>T	uc001oha.1	+	15	1946	c.1812C>T	c.(1810-1812)TCC>TCT	p.S604S	PACS1_uc010rou.1_Silent_p.S140S	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	604					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						CCGTGCTGTCCGCCCTGCTCA	0.617000													33	149					0	0	1	0	0
KLC2	64837	broad.mit.edu	37	11	66031185	66031185	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:66031185C>T	uc010rov.1	+	6	1050	c.807C>T	c.(805-807)ATC>ATT	p.I269I	KLC2_uc010row.1_Silent_p.I269I|KLC2_uc009yra.2_Intron|KLC2_uc001ohb.2_Silent_p.I269I|KLC2_uc010rox.1_Silent_p.I192I|KLC2_uc001ohc.2_Silent_p.I269I|KLC2_uc001ohd.2_Silent_p.I192I|KLC2_uc001ohe.1_Silent_p.I130I	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	269	TPR 2.				blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						CTCTGGCCATCCGGGAGAAAA	0.627000													13	77					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66192534	66192534	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:66192534G>A	uc001ohx.1	+	7	2349	c.2173G>A	c.(2173-2175)GAA>AAA	p.E725K	NPAS4_uc010rpc.1_Missense_Mutation_p.E515K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	725					transcription, DNA-dependent		DNA binding|signal transducer activity				0						TCCCAGTGAGGAATGGGGCTC	0.602000													10	86					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66359062	66359062	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:66359062G>A	uc001oiq.3	-	1	1493	c.1425C>T	c.(1423-1425)CCC>CCT	p.P475P	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	475										ovary(1)|skin(1)	2						CAATGGCTTTGGGATCCAGTT	0.478000													24	145					0	0	1	0	0
SSH3	54961	broad.mit.edu	37	11	67076895	67076896	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:67076895_67076896GG>AA	uc001okj.2	+	11	1267_1268	c.1089_1090GG>AA	c.(1087-1092)CGGGAG>CGAAAG	p.E364K	SSH3_uc001okk.2_RNA|SSH3_uc001okl.2_Missense_Mutation_p.E218K	NM_017857	NP_060327	Q8TE77	SSH3_HUMAN	slingshot homolog 3	364	Tyrosine-protein phosphatase.				regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			ACATGGCCCGGGAGATTGACAA	0.629000													20	111					0	0	1	0	0
UCP2	7351	broad.mit.edu	37	11	73688040	73688040	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:73688040G>A	uc001oup.1	-	5	740	c.360C>T	c.(358-360)CTC>CTT	p.L120L	UCP2_uc001ouq.1_Silent_p.L120L	NM_003355	NP_003346	P55851	UCP2_HUMAN	uncoupling protein 2	120	Solcar 2.|Helical; Name=3; (Potential).				proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding				0	Breast(11;0.000112)					TGCCTGCTAGGAGGCGGCTCC	0.632000													27	82					0	0	1	0	0
MAP6	4135	broad.mit.edu	37	11	75298635	75298635	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:75298635C>T	uc001owu.2	-	4	1976	c.1911G>A	c.(1909-1911)AAG>AAA	p.K637K		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	637	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					GATCTTGATCCTTGATAGGTG	0.522000													23	115					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75501281	75501281	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:75501281G>T	uc001oxa.2	+	3	558	c.299G>T	c.(298-300)TGG>TTG	p.W100L	DGAT2_uc001oxb.2_Missense_Mutation_p.W57L	NM_032564	NP_115953	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	100	Helical; (Potential).				glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	Ovarian(111;0.103)					ACTGATTGCTGGCTCATCGCT	0.557000													34	191					6.29468e-14	6.35997e-14	1	1	0
MYO7A	4647	broad.mit.edu	37	11	76912662	76912662	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:76912662C>T	uc001oyb.2	+	36	5294	c.5022C>T	c.(5020-5022)ACC>ACT	p.T1674T	MYO7A_uc010rsm.1_Silent_p.T1625T|MYO7A_uc001oyc.2_Silent_p.T1636T|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Silent_p.T846T|MYO7A_uc001oye.2_5'Flank	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1674					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCACTGTCACCATGCCACCGC	0.592000													18	63					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76980007	76980007	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:76980007G>A	uc001oyf.2	-	8	837	c.586C>T	c.(586-588)CCC>TCC	p.P196S		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	196	Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						GTTGGCTTGGGCCCCAAATTC	0.458000													18	92					0	0	1	0	0
ODZ4	26011	broad.mit.edu	37	11	78443363	78443363	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:78443363G>A	uc001ozl.3	-	21	3599	c.3136C>T	c.(3136-3138)CAG>TAG	p.Q1046*		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1046	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CTGGGTACCTGAATTTCCGGC	0.517000													7	47					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82880097	82880097	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:82880097C>T	uc001ozx.3	+	8	3065	c.2720C>T	c.(2719-2721)CCC>CTC	p.P907L	PCF11_uc010rsu.1_Missense_Mutation_p.P1038L	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	907	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						TTTGATAATCCCCGAGGTCAG	0.547000													5	48					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534138	92534138	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:92534138C>T	uc001pdj.3	+	9	7976	c.7959C>T	c.(7957-7959)ATC>ATT	p.I2653I		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2653	Cadherin 24.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCCTGGAAATCGATCCTGACA	0.463000										TCGA Ovarian(4;0.039)			6	11					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93127673	93127673	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:93127673G>A	uc001pdq.2	+	10	1190	c.1090G>A	c.(1090-1092)GAA>AAA	p.E364K	CCDC67_uc001pdo.1_Missense_Mutation_p.E364K|CCDC67_uc001pdp.2_Missense_Mutation_p.E364K	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	364	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				CTCTGAGCAGGAAAGAATGAG	0.393000													5	8					0	0	1	0	0
CCDC67	159989	broad.mit.edu	37	11	93127724	93127724	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:93127724G>A	uc001pdq.2	+	10	1241	c.1141G>A	c.(1141-1143)GAG>AAG	p.E381K	CCDC67_uc001pdo.1_Missense_Mutation_p.E381K|CCDC67_uc001pdp.2_Missense_Mutation_p.E381K	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	381	Potential.									ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TCATCAGAAGGAGATCACTAT	0.373000													4	18					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93837869	93837869	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:93837869G>A	uc001pep.2	+	16	3015	c.2858G>A	c.(2857-2859)CGA>CAA	p.R953Q	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	953	Extracellular (Potential).|Plastocyanin-like 6.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AAAGATCCACGAGATTTTAAG	0.343000													18	104					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103070080	103070080	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:103070080G>A	uc001pho.2	+	49	8107	c.7963G>A	c.(7963-7965)GGA>AGA	p.G2655R	DYNC2H1_uc001phn.1_Missense_Mutation_p.G2655R|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2655	AAA 4 (By similarity).|ATP (Potential).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCTATTAGCAGGACGCAGTGG	0.433000													10	26					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103128461	103128461	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:103128461G>A	uc001pho.2	+	69	10730	c.10586G>A	c.(10585-10587)CGA>CAA	p.R3529Q	DYNC2H1_uc001phn.1_Missense_Mutation_p.R3536Q|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3529					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTTTTCCAACGAGCTCTACAA	0.363000													3	12					0	0	1	0	0
CASP5	838	broad.mit.edu	37	11	104877954	104877954	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:104877954C>T	uc010rva.1	-	3	321	c.289G>A	c.(289-291)GAA>AAA	p.E97K	CASP5_uc010ruz.1_Missense_Mutation_p.E110K|CASP5_uc010rvb.1_Missense_Mutation_p.E39K|CASP5_uc010rvc.1_Intron|CASP5_uc009yxh.2_5'UTR|CASP5_uc010rvd.1_Intron	NM_004347	NP_004338	P51878	CASP5_HUMAN	caspase 5 isoform a precursor	97	CARD.				apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			ovary(2)|lung(1)	3		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		TTTTCCTCTTCCTTCAATGTC	0.358000													15	36					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106849448	106849448	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:106849448C>T	uc001pjg.1	-	3	774	c.384G>A	c.(382-384)AAG>AAA	p.K128K	GUCY1A2_uc010rvo.1_Silent_p.K128K|GUCY1A2_uc009yxn.1_Silent_p.K128K	NM_000855	NP_000846	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	128					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			large_intestine(3)|lung(2)|pancreas(2)|ovary(1)	8		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		TGTGGAAATTCTTTTCTGCAT	0.368000													10	33					0	0	1	0	0
NPAT	4863	broad.mit.edu	37	11	108031659	108031659	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:108031659G>A	uc001pjz.3	-	17	4256	c.4154C>T	c.(4153-4155)TCT>TTT	p.S1385F	NPAT_uc010rvv.1_Missense_Mutation_p.S441F	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	1385					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		ATTTTTACTAGAAGGACGAGA	0.338000													3	24					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108409790	108409790	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:108409790C>T	uc001pkk.2	-	3	515	c.404G>A	c.(403-405)GGA>GAA	p.G135E	EXPH5_uc010rvy.1_5'Flank|EXPH5_uc010rvz.1_5'Flank|EXPH5_uc010rwa.1_Missense_Mutation_p.G59E	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	135					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		AGTCTCCTTTCCAGATTTCCT	0.438000													20	71					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108562653	108562653	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:108562653C>T	uc001pkm.2	+	8	1091	c.1026C>T	c.(1024-1026)ATC>ATT	p.I342I	DDX10_uc001pkl.1_Silent_p.I342I	NM_004398	NP_004389	Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	342	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|lung(1)|prostate(1)	4		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		GTGTTTCTATCCTTGCACTCC	0.458000			T	NUP98	AML*								27	81					0	0	1	0	0
ARHGAP20	57569	broad.mit.edu	37	11	110451785	110451785	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:110451785C>T	uc001pkz.1	-	16	2170	c.1885G>A	c.(1885-1887)GAG>AAG	p.E629K	ARHGAP20_uc001pky.1_Missense_Mutation_p.E606K|ARHGAP20_uc009yyb.1_Missense_Mutation_p.E593K|ARHGAP20_uc001pla.1_Missense_Mutation_p.E593K|ARHGAP20_uc001plb.2_Missense_Mutation_p.E172K	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	629					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		CCTTCCACCTCGGGCTGGTCA	0.478000													14	77					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113283333	113283333	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:113283333C>T	uc001pnz.2	-	6	1404	c.1083G>A	c.(1081-1083)AGG>AGA	p.R361R	DRD2_uc010rwv.1_Silent_p.R360R|DRD2_uc001poa.3_Silent_p.R361R|DRD2_uc001pob.3_Silent_p.R332R	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	361	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGGAGAGCTTCCTACGGCTCA	0.567000													22	84					0	0	1	0	0
HTR3B	9177	broad.mit.edu	37	11	113816737	113816737	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:113816737G>A	uc001pok.2	+	9	1271	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K	HTR3B_uc001pol.2_Missense_Mutation_p.E391K	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	402	Cytoplasmic (Potential).|HA-stretch.				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		AGACCAACAGGAGGCAGAGTG	0.557000													14	52					0	0	1	0	0
FAM55D	54827	broad.mit.edu	37	11	114453639	114453639	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:114453639C>T	uc001ppc.2	-	3	382	c.201G>A	c.(199-201)GAG>GAA	p.E67E	FAM55D_uc001ppd.2_5'UTR	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	67						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		TGAGTTCAGTCTCTGTTAGTG	0.448000													40	158					0	0	1	0	0
MLL	4297	broad.mit.edu	37	11	118373727	118373727	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:118373727C>T	uc001pta.2	+	27	7134	c.7111C>T	c.(7111-7113)CAT>TAT	p.H2371Y	MLL_uc001ptb.2_Missense_Mutation_p.H2374Y	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2371					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CCCACACCTCCATTTGAGAGG	0.448000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								10	46					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118951815	118951815	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:118951815C>T	uc010ryx.1	+	16	2494	c.2452C>T	c.(2452-2454)CAA>TAA	p.Q818*	VPS11_uc010ryy.1_Nonsense_Mutation_p.Q664*	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	818					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		TAAGATTTTCCAAAAGACCAA	0.502000													63	261					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120702667	120702667	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:120702667G>A	uc001pxn.2	+	7	905	c.618G>A	c.(616-618)GAG>GAA	p.E206E	GRIK4_uc009zav.1_Silent_p.E206E|GRIK4_uc009zaw.1_Silent_p.E206E|GRIK4_uc009zax.1_Silent_p.E206E	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	206	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TCCTCAAGGAGATCCGGGACG	0.617000													34	156					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774920	122774920	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:122774920C>T	uc001pym.2	+	3	929	c.632C>T	c.(631-633)TCA>TTA	p.S211L	C11orf63_uc001pyl.1_Missense_Mutation_p.S211L	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	211										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AAGCCGTTTTCAGAGCTGAGC	0.517000													15	79					0	0	1	0	0
HSPA8	3312	broad.mit.edu	37	11	122931850	122931850	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:122931850C>T	uc001pyo.2	-	2	261	c.183G>A	c.(181-183)ATG>ATA	p.M61I	HSPA8_uc009zbc.2_5'Flank|HSPA8_uc001pyp.2_Missense_Mutation_p.M61I|HSPA8_uc010rzu.1_Missense_Mutation_p.M61I|HSPA8_uc009zbd.1_Missense_Mutation_p.M61I|HSPA8_uc010rzv.1_Missense_Mutation_p.M61I	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	61					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGTGGGGTTCATTGCAACTT	0.433000													11	43					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123813765	123813765	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:123813765G>A	uc010sab.1	-	1	781	c.781C>T	c.(781-783)CGT>TGT	p.R261C		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TCTGACATACGAATGTAGAGA	0.517000													17	91					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886639	123886639	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:123886639G>A	uc010sac.1	+	1	358	c.358G>A	c.(358-360)GAT>AAT	p.D120N		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	120	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CATGTCCTATGATCGCTACTT	0.567000													8	160					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294222	124294222	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:124294222G>A	uc010sak.1	-	1	546	c.546C>T	c.(544-546)CCC>CCT	p.P182P		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GCTGCAAGAGGGGGAGAACGT	0.507000													7	15					0	0	1	0	0
OR8B8	26493	broad.mit.edu	37	11	124310050	124310050	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:124310050G>A	uc010sal.1	-	1	932	c.932C>T	c.(931-933)TCC>TTC	p.S311F		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		CTTTTCTCAGGAGAATGCATT	0.388000													11	50					0	0	1	0	0
OR8B8	26493	broad.mit.edu	37	11	124310841	124310841	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:124310841G>A	uc010sal.1	-	1	141	c.141C>T	c.(139-141)ACC>ACT	p.T47T		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	47	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GCCTTATCAGGGTTATCAAGC	0.483000													18	77					0	0	1	0	0
OR8B12	219858	broad.mit.edu	37	11	124413467	124413467	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:124413467G>A	uc010sam.1	-	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		CCAGAAACAGGAAGAAGAGGG	0.532000													9	76					0	0	1	0	0
OR8A1	390275	broad.mit.edu	37	11	124440102	124440102	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:124440102C>T	uc010san.1	+	1	138	c.138C>T	c.(136-138)CTC>CTT	p.L46L		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		CCCTCTTTCTCCTCTTCCTCG	0.512000													12	57					0	0	1	0	0
BARX2	8538	broad.mit.edu	37	11	129306729	129306729	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:129306729C>T	uc001qfc.3	+	2	321	c.271C>T	c.(271-273)CCG>TCG	p.P91S		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	BarH-like homeobox 2	91											0	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		CCCTGCCACCCCGGGAATCGC	0.677000													38	174					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130332501	130332501	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:130332501C>T	uc010scd.1	+	4	1368	c.1368C>T	c.(1366-1368)TCC>TCT	p.S456S		NM_139055	NP_620686	Q8TE58	ATS15_HUMAN	a disintegrin-like and metalloprotease	456	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|pancreas(1)|lung(1)|skin(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GCGTGGGCTCCAAGCCCTGTC	0.647000													27	101					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	1005395	1005395	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:1005395C>T	uc001qio.3	+	24	6249	c.5742C>T	c.(5740-5742)ATC>ATT	p.I1914I	WNK1_uc001qip.3_Silent_p.I1666I|WNK1_uc001qir.3_Silent_p.I1087I	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1914					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GCATAACCATCCCTGGTATCT	0.498000													11	52					0	0	1	0	0
ERC1	23085	broad.mit.edu	37	12	1289817	1289817	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:1289817A>G	uc001qjb.2	+	9	2090	c.1849A>G	c.(1849-1851)ACT>GCT	p.T617A	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.T589A|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.T617A|ERC1_uc010sdv.1_Missense_Mutation_p.T365A|ERC1_uc009zdp.2_Missense_Mutation_p.T257A	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	617	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			TGCCTTGACAACTTTGGAGGA	0.473000													30	122					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2614051	2614051	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:2614051T>C	uc009zdu.1	+	8	1470	c.1157T>C	c.(1156-1158)GTT>GCT	p.V386A	CACNA1C_uc009zdv.1_Missense_Mutation_p.V383A|CACNA1C_uc001qkb.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkc.2_Missense_Mutation_p.V386A|CACNA1C_uc001qke.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkf.2_Missense_Mutation_p.V386A|CACNA1C_uc001qjz.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkd.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkg.2_Missense_Mutation_p.V386A|CACNA1C_uc009zdw.1_Missense_Mutation_p.V386A|CACNA1C_uc001qkh.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkl.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkp.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkr.2_Missense_Mutation_p.V386A|CACNA1C_uc001qku.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkq.2_Missense_Mutation_p.V386A|CACNA1C_uc001qks.2_Missense_Mutation_p.V386A|CACNA1C_uc001qkt.2_Missense_Mutation_p.V386A|CACNA1C_uc001qka.1_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Intron|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron|CACNA1C_uc009zdy.1_Intron|CACNA1C_uc001qkv.1_5'UTR	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	386	I.|Helical; Name=S6 of repeat I; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ATCTATTTTGTTACACTAATC	0.458000													7	36					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2690858	2690858	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:2690858C>T	uc009zdu.1	+	14	2311	c.1998C>T	c.(1996-1998)TCC>TCT	p.S666S	CACNA1C_uc009zdv.1_Silent_p.S663S|CACNA1C_uc001qkb.2_Silent_p.S666S|CACNA1C_uc001qkc.2_Silent_p.S666S|CACNA1C_uc001qke.2_Silent_p.S666S|CACNA1C_uc001qkf.2_Silent_p.S666S|CACNA1C_uc001qjz.2_Silent_p.S666S|CACNA1C_uc001qkd.2_Silent_p.S666S|CACNA1C_uc001qkg.2_Silent_p.S666S|CACNA1C_uc009zdw.1_Silent_p.S666S|CACNA1C_uc001qkh.2_Silent_p.S666S|CACNA1C_uc001qkl.2_Silent_p.S666S|CACNA1C_uc001qkn.2_Silent_p.S666S|CACNA1C_uc001qko.2_Silent_p.S666S|CACNA1C_uc001qkp.2_Silent_p.S666S|CACNA1C_uc001qkr.2_Silent_p.S666S|CACNA1C_uc001qku.2_Silent_p.S666S|CACNA1C_uc001qkq.2_Silent_p.S666S|CACNA1C_uc001qks.2_Silent_p.S666S|CACNA1C_uc001qkt.2_Silent_p.S666S|CACNA1C_uc001qka.1_Silent_p.S201S|CACNA1C_uc001qki.1_Silent_p.S402S|CACNA1C_uc001qkj.1_Silent_p.S402S|CACNA1C_uc001qkk.1_Silent_p.S402S|CACNA1C_uc001qkm.1_Silent_p.S402S|CACNA1C_uc001qkw.2_5'Flank	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	666	II.|Helical; Name=S5 of repeat II; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	tcatcttctccctcctGGGGA	0.423000													6	28					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154998	5154998	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:5154998C>T	uc001qni.2	+	1	1914	c.1685C>T	c.(1684-1686)TCC>TTC	p.S562F		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	562						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						AGCAGGGGATCCTTCTGCAAG	0.642000													5	33					0	0	1	0	0
PLEKHG6	55200	broad.mit.edu	37	12	6437012	6437012	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:6437012G>A	uc001qnr.2	+	15	2411	c.2263G>A	c.(2263-2265)GAG>AAG	p.E755K	PLEKHG6_uc010sew.1_Missense_Mutation_p.E755K|PLEKHG6_uc010sex.1_Missense_Mutation_p.E723K	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	755					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						TGAGGGGGCCGAGGAGCCCCG	0.657000													4	21					0	0	1	0	0
LOC642846	642846	broad.mit.edu	37	12	9453800	9453800	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:9453800C>T	uc010sgp.1	+	10		c.1439C>T			LOC642846_uc001qvp.2_RNA	NR_024374				Homo sapiens cDNA FLJ60280 complete cds, highly similar to Probable ATP-dependent RNA helicase DDX11 (EC 3.6.1.-).												0						ACCTGATCGACACCATCACGG	0.667000													12	105					0	0	1	0	0
KLRC4	8302	broad.mit.edu	37	12	10562066	10562066	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:10562066C>T	uc001qye.2	-	1	291	c.109G>A	c.(109-111)GAA>AAA	p.E37K	KLRK1_uc001qyc.2_5'Flank|KLRK1_uc009zhk.2_5'UTR|KLRK1_uc001qyd.2_Intron	NM_013431	NP_038459	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C,	37	Cytoplasmic (Potential).				cellular defense response	integral to membrane	binding|receptor activity				0						TGGAATATTTCCTGTTTGGTT	0.393000													20	124					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10774549	10774549	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:10774549G>A	uc001qys.2	-	10	1511	c.990C>T	c.(988-990)GTC>GTT	p.V330V		NM_018423	NP_060893	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	330	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(3)|ovary(2)|lung(2)|breast(1)	8						TGGTAGGAGGGACTTCAGGAT	0.423000										HNSCC(73;0.22)			20	82					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978119	10978119	+	Silent	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:10978119A>G	uc001qyy.1	-	1	750	c.750T>C	c.(748-750)TTT>TTC	p.F250F		NM_023921	NP_076410	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	250	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity				0						CTCGCACAGTAAAACATGATA	0.383000													14	56					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461723	11461723	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:11461723C>T	uc001qzf.1	-	3	228	c.194G>A	c.(193-195)GGA>GAA	p.G65E	PRB4_uc001qzt.2_Missense_Mutation_p.G65E	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	65	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|2.					extracellular region				ovary(1)	1						GGACTGGTTTCCTCCTTGTGG	0.622000										HNSCC(22;0.051)			88	452					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14813983	14813983	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:14813983C>T	uc001rcd.2	-	11	1433	c.1296G>A	c.(1294-1296)CTG>CTA	p.L432L		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	432	Helical; (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						CTGCAATCATCAGGATCTGAG	0.512000													16	81					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435579	18435579	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:18435579G>A	uc001rdt.2	+	2	680	c.564G>A	c.(562-564)CCG>CCA	p.P188P	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Silent_p.P188P|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	188					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				ACTTCATGCCGAAAGAAGAGA	0.378000													22	86					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435666	18435666	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:18435666G>A	uc001rdt.2	+	2	767	c.651G>A	c.(649-651)TGG>TGA	p.W217*	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Nonsense_Mutation_p.W217*|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	217					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CCGGAATGTGGGAAAGTACAT	0.358000													27	115					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18691178	18691178	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:18691178G>A	uc001rdt.2	+	24	3405	c.3289G>A	c.(3289-3291)GAA>AAA	p.E1097K	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.E1138K|PIK3C2G_uc010sic.1_Missense_Mutation_p.E916K	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1097	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				AGATTTTGTGGAACTTTGCTG	0.383000													3	23					0	0	1	0	0
LST-3TM12	338821	broad.mit.edu	37	12	21172182	21172182	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:21172182G>A	uc010sin.1	+	2	86	c.86G>A	c.(85-87)GGA>GAA	p.G29E	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	29						membrane	transporter activity				0						CTCTTTCTAGGAAATTTGTTT	0.333000													4	15					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21643307	21643307	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:21643307G>A	uc001rex.2	-	5	568	c.220C>T	c.(220-222)CCA>TCA	p.P74S	RECQL_uc001rey.2_Missense_Mutation_p.P74S	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	74					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						CCAGACCATGGAAAATCTAGG	0.303000								Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					4	21					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22086769	22086769	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:22086769G>A	uc001rfi.1	-	2	251	c.231C>T	c.(229-231)TTC>TTT	p.F77F	ABCC9_uc001rfh.2_Silent_p.F77F|ABCC9_uc001rfj.1_Silent_p.F77F|ABCC9_uc001rfk.2_Silent_p.F77F|ABCC9_uc001rfl.1_Silent_p.F77F	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	77	Helical; Name=2; (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACAGGAGAGCGAATGTAAGAA	0.428000													9	68					0	0	1	0	0
ARNTL2	56938	broad.mit.edu	37	12	27521277	27521277	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:27521277G>A	uc001rht.1	+	2	132	c.114G>A	c.(112-114)ATG>ATA	p.M38I	ARNTL2_uc001rhw.2_Missense_Mutation_p.M49I|ARNTL2_uc010sjp.1_Missense_Mutation_p.M49I|ARNTL2_uc001rhu.1_Missense_Mutation_p.M38I|ARNTL2_uc009zji.1_Missense_Mutation_p.M38I|ARNTL2_uc001rhv.1_Missense_Mutation_p.M38I	NM_020183	NP_064568	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear	38					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|skin(1)	2	Colorectal(261;0.0847)|Lung SC(9;0.184)					CAACAGCTATGGGGTCTTTCA	0.502000													9	68					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33559843	33559843	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:33559843C>T	uc001rll.1	-	3	1255	c.958G>A	c.(958-960)GAT>AAT	p.D320N	SYT10_uc009zju.1_Missense_Mutation_p.D130N	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	320	Cytoplasmic (Potential).|C2 1.	Calcium 2 (By similarity).|Calcium 1 (By similarity).				cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					CTGTCAAAATCATACACACTG	0.363000													11	42					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33579246	33579246	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:33579246C>T	uc001rll.1	-	2	633	c.336G>A	c.(334-336)GAG>GAA	p.E112E	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	112	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTTCTTTTTTCTCTTCAGTCT	0.428000													8	48					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33579405	33579405	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:33579405G>A	uc001rll.1	-	2	474	c.177C>T	c.(175-177)GTC>GTT	p.V59V	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	59	Helical; (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					AGCTGACAACGACAGCTAACA	0.363000													5	24					0	0	1	0	0
PUS7L	83448	broad.mit.edu	37	12	44125510	44125510	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:44125510G>A	uc001rnq.3	-	8	2266	c.1777C>T	c.(1777-1779)CAG>TAG	p.Q593*	PUS7L_uc001rnr.3_Nonsense_Mutation_p.Q593*|PUS7L_uc001rns.3_Nonsense_Mutation_p.Q593*|PUS7L_uc009zkb.2_Nonsense_Mutation_p.Q280*	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	593	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		AAATTTACCTGATGTATTGCA	0.313000													8	17					0	0	1	0	0
AMIGO2	347902	broad.mit.edu	37	12	47472017	47472017	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:47472017C>T	uc001rpm.2	-	3	1424	c.769G>A	c.(769-771)GAT>AAT	p.D257N	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Missense_Mutation_p.D257N|AMIGO2_uc001rpl.2_Missense_Mutation_p.D257N	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	257	Extracellular (Potential).|LRRCT.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					CAGGTGTAATCGTTCTTAAAA	0.473000													13	52					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49169833	49169834	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:49169833_49169834CC>TT	uc001rsh.3	-	8	2378_2379	c.1718_1719GG>AA	c.(1717-1719)CGG>CAA	p.R573Q	ADCY6_uc001rsj.3_Missense_Mutation_p.R573Q|ADCY6_uc001rsi.3_Missense_Mutation_p.R573Q|ADCY6_uc010slw.1_5'Flank	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	573	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						TGGAGTTGGCCCGAGTCCGCTG	0.649000													4	22					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50284881	50284881	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:50284881T>C	uc001rvj.1	-	6	596	c.451A>G	c.(451-453)ACC>GCC	p.T151A	FAIM2_uc001rvi.1_Missense_Mutation_p.T105A|FAIM2_uc001rvk.1_RNA	NM_012306	NP_036438	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	151	Helical; (Potential).				anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|ovary(1)|skin(1)	3						GTCAGGTAGGTTGCAAAGAAC	0.542000													16	101					0	0	1	0	0
AQP5	362	broad.mit.edu	37	12	50358795	50358795	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:50358795C>T	uc001rvo.2	+	4	1155	c.633C>T	c.(631-633)ATC>ATT	p.I211I	AQP6_uc001rvp.1_5'Flank|AQP6_uc001rvq.1_5'Flank	NM_001651	NP_001642	P55064	AQP5_HUMAN	aquaporin 5	211	Helical; (Potential).				carbon dioxide transport|excretion|odontogenesis|pancreatic juice secretion	apical plasma membrane|integral to plasma membrane	protein binding|water channel activity				0						TAGGGCCCATCGTGGGGGCGG	0.612000													16	146					0	0	1	0	0
TFCP2	7024	broad.mit.edu	37	12	51497944	51497944	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:51497944G>A	uc001rxw.2	-	9	1419	c.960C>T	c.(958-960)GTC>GTT	p.V320V	TFCP2_uc001rxv.1_Silent_p.V320V|TFCP2_uc009zlx.1_Silent_p.V269V|TFCP2_uc001rxx.2_Intron|TFCP2_uc009zly.1_Silent_p.V222V	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	320	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTACATCTGTGACTGGAGGGG	0.408000													13	114					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51773463	51773463	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:51773463C>T	uc001ryk.2	-	2	328	c.103G>A	c.(103-105)GAG>AAG	p.E35K	GALNT6_uc009zma.1_RNA|GALNT6_uc001ryl.1_Missense_Mutation_p.E35K|GALNT6_uc010snh.1_Missense_Mutation_p.E35K	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	polypeptide N-acetylgalactosaminyltransferase 6	35	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2						GTGGCCTCCTCTCTGCTGCTC	0.602000													13	62					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52788966	52788966	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:52788966G>A	uc001sai.1	-	9	1450	c.1335C>T	c.(1333-1335)TCC>TCT	p.S445S		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	445	Tail.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		AGGCGCCTTTGGAGCTGCTCA	0.627000													9	34					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53169378	53169378	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:53169378G>A	uc001sax.2	-	2	663	c.609C>T	c.(607-609)TTC>TTT	p.F203F		NM_015848	NP_056932	Q01546	K22O_HUMAN	keratin 76	203	Coil 1A.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|skin(1)	2						GCTGTTCCAGGAACCGCACCT	0.567000													20	78					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53217744	53217744	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:53217744G>A	uc001sbb.2	-	6	1106	c.1073C>T	c.(1072-1074)ACC>ATC	p.T358I	KRT79_uc001sba.2_Missense_Mutation_p.T129I	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	358	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CTCGTTCTTGGTGTCCCGCAG	0.607000													21	55					0	0	1	0	0
ITGB7	3695	broad.mit.edu	37	12	53594030	53594030	+	Silent	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:53594030T>C	uc009zmv.2	-	2	269	c.198A>G	c.(196-198)CAA>CAG	p.Q66Q	ITGB7_uc001scc.2_Silent_p.Q66Q|ITGB7_uc010snz.1_RNA|ITGB7_uc010soa.1_Silent_p.Q66Q	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	66	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						TCTTTACCAGTTGCTTGCACC	0.468000													6	47					0	0	1	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54115879	54115879	+	Missense_Mutation	SNP	C	T	T	rs150332172		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:54115879C>T	uc001sef.2	-	5	683	c.539G>A	c.(538-540)CGA>CAA	p.R180Q	CALCOCO1_uc010som.1_Missense_Mutation_p.R147Q|CALCOCO1_uc010son.1_Missense_Mutation_p.R57Q|CALCOCO1_uc001seh.2_Missense_Mutation_p.R180Q|CALCOCO1_uc009znd.2_Missense_Mutation_p.R180Q|CALCOCO1_uc001seg.2_Missense_Mutation_p.R57Q|CALCOCO1_uc010soo.1_Missense_Mutation_p.R173Q	NM_020898	NP_065949	Q9P1Z2	CACO1_HUMAN	coiled-coil transcriptional coactivator isoform	180	Potential.|N-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			ovary(1)	1						CTCCTGCACTCGGCTCCTCAG	0.607000													26	106					0	0	1	0	0
HOXC13	3229	broad.mit.edu	37	12	54338879	54338879	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:54338879G>A	uc001sei.2	+	2	947	c.832G>A	c.(832-834)GAA>AAA	p.E278K	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	278	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GCTAGAGAAGGAATACGCGGC	0.612000			T	NUP98	AML								27	112					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54963026	54963026	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:54963026G>A	uc001sgd.1	+	4	452	c.286G>A	c.(286-288)GAG>AAG	p.E96K	PDE1B_uc010soz.1_5'UTR|PDE1B_uc010spa.1_Missense_Mutation_p.E55K|PDE1B_uc001sgf.2_Intron|PDE1B_uc001sge.2_Missense_Mutation_p.E76K|PDE1B_uc009znq.2_Intron	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	96					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CGTGCCTTCGGAGGTGCGGGA	0.632000													29	121					0	0	1	0	0
OR9K2	441639	broad.mit.edu	37	12	55524480	55524480	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:55524480C>T	uc010spe.1	+	1	928	c.928C>T	c.(928-930)CCT>TCT	p.P310S		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						CATGTTGAATCCTTTGATTTA	0.358000													23	66					0	0	1	0	0
ERBB3	2065	broad.mit.edu	37	12	56480404	56480404	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:56480404G>A	uc001sjh.2	+	4	704	c.511G>A	c.(511-513)GAT>AAT	p.D171N	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.D112N|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	171	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GAGGGACCGAGATGCTGAGAT	0.498000													29	160					0	0	1	0	0
MARS	4141	broad.mit.edu	37	12	57883328	57883328	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:57883328C>T	uc001sog.2	+	4	424	c.401C>T	c.(400-402)CCT>CTT	p.P134L	ARHGAP9_uc001sod.2_5'Flank|ARHGAP9_uc001soe.1_5'Flank|MARS_uc001sof.1_RNA|MARS_uc010srp.1_Intron|MARS_uc010srq.1_5'UTR	NM_004990	NP_004981	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	134	GST C-terminal.				methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			ovary(3)|central_nervous_system(1)|pancreas(1)	5			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	CAGAACTGTCCTTTCCTGGCT	0.393000													13	58					0	0	1	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57987836	57987836	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:57987836C>T	uc001sou.2	+	2	334	c.203C>T	c.(202-204)CCG>CTG	p.P68L	PIP4K2C_uc001sot.2_Missense_Mutation_p.P68L|PIP4K2C_uc010srs.1_Missense_Mutation_p.P68L|PIP4K2C_uc010srt.1_Missense_Mutation_p.P68L	NM_001146258	NP_001139730	Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type	68	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			central_nervous_system(2)|lung(1)	3	Melanoma(17;0.122)					GTGCCTCCCCCGGTGATGCTG	0.502000													17	64					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62929322	62929322	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:62929322C>T	uc001sre.2	+	14	2124	c.1733C>T	c.(1732-1734)ACT>ATT	p.T578I	MON2_uc009zqj.2_Missense_Mutation_p.T578I|MON2_uc010ssl.1_Missense_Mutation_p.T506I|MON2_uc010ssm.1_Missense_Mutation_p.T578I|MON2_uc010ssn.1_Missense_Mutation_p.T578I|MON2_uc001srf.2_Missense_Mutation_p.T341I	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	578					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		GAAGCTGCCACTGAGAATATT	0.338000													14	60					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62979270	62979270	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:62979270C>T	uc001sre.2	+	33	5287	c.4896C>T	c.(4894-4896)TGC>TGT	p.C1632C	MON2_uc009zqj.2_Silent_p.C1632C|MON2_uc010ssl.1_Silent_p.C1560C|MON2_uc010ssm.1_Silent_p.C1603C|MON2_uc010ssn.1_Silent_p.C1626C|MON2_uc001srf.2_Silent_p.C1395C|MON2_uc001srg.2_Silent_p.C501C	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1633					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		GTGGTAAATGCCCTCTTCCAA	0.333000													6	23					0	0	1	0	0
SRGAP1	57522	broad.mit.edu	37	12	64521469	64521469	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:64521469C>T	uc010ssp.1	+	20	2561	c.2505C>T	c.(2503-2505)TCC>TCT	p.S835S	SRGAP1_uc001srv.2_Silent_p.S772S	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	835					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		ACATGAACTCCCCGACAGACC	0.572000													7	48					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70070743	70070743	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:70070743G>A	uc001svg.2	-	7	1047	c.820C>T	c.(820-822)CCC>TCC	p.P274S	BEST3_uc001svd.1_Missense_Mutation_p.P274S|BEST3_uc001sve.1_Intron|BEST3_uc001svf.2_Intron|BEST3_uc010stm.1_Missense_Mutation_p.P168S|BEST3_uc001svh.2_Intron	NM_032735	NP_116124	Q8N1M1	BEST3_HUMAN	vitelliform macular dystrophy 2-like 3 isoform	274	Helical; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GTGAAGATGGGAATGTAAAGA	0.483000													21	95					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72680484	72680484	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:72680484C>T	uc001sxa.2	+	2	833	c.803C>T	c.(802-804)TCG>TTG	p.S268L		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	268	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						ACTCAGTTTTCGCCTACACAT	0.363000													9	52					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373294	86373294	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:86373294C>T	uc001tai.3	-	8	2460	c.1210G>A	c.(1210-1212)GAT>AAT	p.D404N	MGAT4C_uc001tal.3_Missense_Mutation_p.D404N|MGAT4C_uc001taj.3_Missense_Mutation_p.D404N|MGAT4C_uc001tak.3_Missense_Mutation_p.D404N|MGAT4C_uc010sum.1_Missense_Mutation_p.D428N|MGAT4C_uc001tah.3_Missense_Mutation_p.D404N	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	404	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TGCAAAATATCATTTTGCCGA	0.328000													5	34					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502721	91502721	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:91502721C>T	uc001tbm.2	-	2	425	c.36G>A	c.(34-36)TTG>TTA	p.L12L	LUM_uc001tbn.2_Intron	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	12					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						TACCACCAATCAATGCCAGGA	0.343000													9	36					0	0	1	0	0
HAL	3034	broad.mit.edu	37	12	96388721	96388721	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:96388721C>T	uc001tem.1	-	3	595	c.298G>A	c.(298-300)GGA>AGA	p.G100R	HAL_uc009zti.1_RNA|HAL_uc010suw.1_5'UTR|HAL_uc010sux.1_Missense_Mutation_p.G100R	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	100					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	AGATAAACTCCTTCTGGTTGA	0.493000													28	75					0	0	1	0	0
C12orf63	374467	broad.mit.edu	37	12	97057618	97057618	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:97057618G>A	uc001tet.1	+	6	824	c.746G>A	c.(745-747)CGA>CAA	p.R249Q		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	249										skin(6)|ovary(1)	7						ATAACTTGCCGAAATTTCATT	0.308000													6	37					0	0	1	0	0
NR1H4	9971	broad.mit.edu	37	12	100904661	100904661	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:100904661C>T	uc001tht.1	+	2	243	c.215C>T	c.(214-216)TCC>TTC	p.S72F	NR1H4_uc001thp.1_Missense_Mutation_p.S62F|NR1H4_uc001thq.1_Missense_Mutation_p.S62F|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.S62F|NR1H4_uc010svk.1_Missense_Mutation_p.S62F|NR1H4_uc001ths.1_Missense_Mutation_p.S72F	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	72					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CCACAGATTTCCTCGTCATCC	0.483000													11	71					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101584379	101584379	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:101584379G>A	uc001thz.3	-	6	1090	c.700C>T	c.(700-702)CCT>TCT	p.P234S		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	234	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						AAAGGGTTAGGATTAAAACTA	0.378000													4	27					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101603315	101603315	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:101603315G>A	uc001thz.3	-	1	702	c.312C>T	c.(310-312)CTC>CTT	p.L104L		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	104	Helical; (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						AGAACACCGGGAGGAAGACCT	0.592000													5	20					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101703550	101703550	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:101703550C>T	uc001tia.1	+	19	2320	c.2164C>T	c.(2164-2166)CGT>TGT	p.R722C		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	722					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GGTGCCGCTTCGTTATTTGTT	0.358000													19	110					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101777418	101777419	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:101777418_101777419GG>AA	uc001tia.1	+	60	8183_8184	c.8027_8028GG>AA	c.(8026-8028)CGG>CAA	p.R2676Q		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2676					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						CCTTTGTTTCGGGAACTCAACA	0.465000													23	124					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102811603	102811603	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:102811603C>T	uc001tjp.3	-	4	800	c.581G>A	c.(580-582)GGA>GAA	p.G194E	IGF1_uc001tjn.2_Intron|IGF1_uc001tjm.2_Intron|IGF1_uc001tjo.2_Intron	NM_001111285	NP_001104755	P05019	IGF1_HUMAN	insulin-like growth factor 1 isoform 3	194					anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|pancreas(1)	2						CCTTCATTTTCCTTTTTTGCC	0.438000													55	221					0	0	1	0	0
SVOP	55530	broad.mit.edu	37	12	109328001	109328001	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:109328001C>T	uc010sxh.1	-	10	1190	c.1018G>A	c.(1018-1020)GAA>AAA	p.E340K		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	340	Vesicular (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						TGGAAGAGTTCTGTGGTGAGT	0.488000													4	12					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111772375	111772375	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:111772375C>T	uc001tsa.1	+	19	3210	c.3057C>T	c.(3055-3057)TCC>TCT	p.S1019S		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	1019						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						AGGGCCGCTCCAGCTCCTCGT	0.657000													15	48					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113307579	113307579	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:113307579G>A	uc010syl.1	+	9	988	c.626G>A	c.(625-627)AGG>AAG	p.R209K	RPH3A_uc001ttz.2_Missense_Mutation_p.R209K|RPH3A_uc001tty.2_Missense_Mutation_p.R205K|RPH3A_uc009zwe.1_Missense_Mutation_p.R205K|RPH3A_uc010sym.1_Missense_Mutation_p.R160K|RPH3A_uc001tua.2_5'UTR	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	209	Pro-rich.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		AGTGAAGATAGGAGGGGCCCG	0.463000													27	114					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113405379	113405379	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:113405379T>G	uc001tug.2	+	13	2933	c.2846T>G	c.(2845-2847)GTG>GGG	p.V949G		NM_006187	NP_006178	Q9Y6K5	OAS3_HUMAN	2'-5'oligoadenylate synthetase 3	949	OAS domain 3.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			central_nervous_system(1)	1						ATCCGGCTGGTGAAGCACTGG	0.582000													6	25					0	0	1	0	0
RASAL1	8437	broad.mit.edu	37	12	113553474	113553474	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:113553474C>T	uc001tum.1	-	11	1262	c.969G>A	c.(967-969)CTG>CTA	p.L323L	RASAL1_uc010syp.1_Silent_p.L323L|RASAL1_uc001tul.2_Silent_p.L323L|RASAL1_uc001tun.1_Silent_p.L323L|RASAL1_uc010syq.1_Silent_p.L323L|RASAL1_uc001tuo.3_Silent_p.L323L|RASAL1_uc010syr.1_Silent_p.L323L	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	323	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						TGAGATAGTCCAGAAAGCGCC	0.637000													9	27					0	0	1	0	0
C12orf49	79794	broad.mit.edu	37	12	117158139	117158139	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:117158139A>T	uc001tvz.1	-	3	520	c.382T>A	c.(382-384)TAT>AAT	p.Y128N	C12orf49_uc009zwm.1_Missense_Mutation_p.Y98N	NM_024738	NP_079014	Q9H741	CL049_HUMAN	hypothetical protein LOC79794 precursor	128	Cys-rich.					extracellular region				ovary(1)	1	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0281)		CAGTACTCATAGGCGCTGCAG	0.532000													19	62					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117680496	117680496	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:117680496G>A	uc001twm.1	-	20	3663	c.2977C>T	c.(2977-2979)CAC>TAC	p.H993Y		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	993					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CGCTTTTTGTGGACATTGGAT	0.448000													9	67					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117922329	117922329	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:117922329C>T	uc001two.2	-	16	2310	c.2255G>A	c.(2254-2256)GGA>GAA	p.G752E		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	781	Protein kinase.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTGTAGGATTCCCTTGGCGTG	0.512000													5	30					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120608117	120608117	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:120608117G>A	uc001txo.2	-	15	1388	c.1375C>T	c.(1375-1377)CTG>TTG	p.L459L		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	459					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCCTGCAACAGCGTGTCACCT	0.532000													13	104					0	0	1	0	0
VPS37B	79720	broad.mit.edu	37	12	123351786	123351786	+	Silent	SNP	G	A	A	rs138310143	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:123351786G>A	uc001udl.2	-	4	838	c.735C>T	c.(733-735)CCC>CCT	p.P245P		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	245	Pro-rich.				cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		GGCCCACGCGGGGGGGCAGGG	0.687000													18	66					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124274641	124274641	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:124274641G>A	uc001uft.3	+	11	1630	c.1605G>A	c.(1603-1605)GTG>GTA	p.V535V	DNAH10_uc010tav.1_Silent_p.V20V|DNAH10_uc010taw.1_Silent_p.V20V	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	535	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGAAATATGTGATGGATGAAT	0.458000													43	161					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124399056	124399056	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:124399056C>T	uc001uft.3	+	60	10204	c.10179C>T	c.(10177-10179)TTC>TTT	p.F3393F		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3393					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCCAGCCTTTCCGGCTGGAAA	0.592000													9	42					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124824854	124824854	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:124824854G>A	uc010tba.1	-	36	5615	c.5498C>T	c.(5497-5499)CCC>CTC	p.P1833L	NCOR2_uc010tay.1_Missense_Mutation_p.P1832L|NCOR2_uc010taz.1_Missense_Mutation_p.P1816L|NCOR2_uc010tbb.1_Missense_Mutation_p.P1825L|NCOR2_uc010tbc.1_Missense_Mutation_p.P1815L|NCOR2_uc010tax.1_5'Flank	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1833					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCTCCAGATGGGTGCGTGCTC	0.677000													10	23					0	0	1	0	0
AACS	65985	broad.mit.edu	37	12	125558421	125558421	+	Splice_Site	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:125558421G>A	uc001uhc.2	+	2	340	c.134_splice	c.e2-1	p.E45_splice	AACS_uc009zyg.2_Splice_Site|AACS_uc001uhd.2_Splice_Site_p.E45_splice|AACS_uc009zyh.2_5'Flank	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase						fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		TTCATTTTTAGAGAGTTATGA	0.418000													15	49					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128661	126128661	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:126128661G>A	uc001uhe.1	+	6	1470	c.1462G>A	c.(1462-1464)GAA>AAA	p.E488K	TMEM132B_uc001uhf.1_5'UTR	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	488	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAATGGGAAGGAAATGAAGAG	0.483000													12	81					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138866	126138866	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:126138866G>A	uc001uhe.1	+	9	2855	c.2847G>A	c.(2845-2847)GGG>GGA	p.G949G	TMEM132B_uc001uhf.1_Silent_p.G461G	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	949	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCTGGCTTGGGAATGAAGTGG	0.517000													16	65					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126139082	126139082	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:126139082G>A	uc001uhe.1	+	9	3071	c.3063G>A	c.(3061-3063)AGG>AGA	p.R1021R	TMEM132B_uc001uhf.1_Silent_p.R533R	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	1021	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GCCCAAAGAGGAAGAGAGTCA	0.458000													12	51					0	0	1	0	0
TMEM132C	92293	broad.mit.edu	37	12	128899597	128899597	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:128899597C>T	uc001uhs.3	+	1	307	c.70C>T	c.(70-72)CTG>TTG	p.L24L		NM_001136103	NP_001129575	Q8N3T6	T132C_HUMAN	transmembrane protein 132C	136	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						AGCCCACATCCTGCGGGACAA	0.498000													5	7					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129559536	129559536	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:129559536C>T	uc009zyl.1	-	9	2512	c.2184G>A	c.(2182-2184)GGG>GGA	p.G728G	TMEM132D_uc001uia.2_Silent_p.G266G	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	728	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AGAAGTCTTTCCCATCGTAAA	0.458000													21	74					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	A	A	rs12366766		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:132547087G>A	uc001ujn.2	+	46	8210	c.8175G>A	c.(8173-8175)CAG>CAA	p.Q2725Q	EP400_uc001ujl.2_Silent_p.Q2724Q|EP400_uc001ujm.2_Silent_p.Q2644Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.289000													12	43					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751395	19751395	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:19751395C>T	uc009zzj.2	-	4	777	c.728G>A	c.(727-729)CGA>CAA	p.R243Q		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	243					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCCGTCAAATCGCAGGGAGGC	0.597000													41	201					0	0	1	0	0
ATP12A	479	broad.mit.edu	37	13	25275005	25275005	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:25275005C>T	uc001upp.2	+	13	2013	c.1826C>T	c.(1825-1827)CCC>CTC	p.P609L	ATP12A_uc010aaa.2_Missense_Mutation_p.P615L	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	609	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATGATCGATCCCCCTCGGTCC	0.488000													17	74					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28895678	28895678	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:28895678C>T	uc001usb.3	-	23	3381	c.3096G>A	c.(3094-3096)GAG>GAA	p.E1032E	FLT1_uc010aap.2_Silent_p.E37E|FLT1_uc010aaq.2_Silent_p.E157E|FLT1_uc001usa.3_Silent_p.E250E	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1032	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CCACGTTGTTCTCAGATAAAA	0.373000													7	64					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29608172	29608172	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:29608172C>T	uc001usl.3	+	2	2444	c.2386C>T	c.(2386-2388)CTG>TTG	p.L796L		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	786	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						GAGCAGGATTCTGATTGCAAG	0.517000													14	36					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29608252	29608252	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:29608252C>T	uc001usl.3	+	2	2524	c.2466C>T	c.(2464-2466)TCC>TCT	p.S822S		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	812	Sufficient for interaction with KIF2C.|Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TCTACAGTTCCGATCCTTCAG	0.463000													26	41					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32915326	32915326	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:32915326C>T	uc001uub.1	+	11	7061	c.6834C>T	c.(6832-6834)ATC>ATT	p.I2278I		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	2278					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AGCCCCTTATCTTAGTGGGTA	0.353000			D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			20	87					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33681071	33681071	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:33681071C>T	uc001uuw.2	-	13	3174	c.3048G>A	c.(3046-3048)AGG>AGA	p.R1016R	STARD13_uc001uuu.2_Silent_p.R1008R|STARD13_uc001uuv.2_Silent_p.R898R|STARD13_uc001uux.2_Silent_p.R981R|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	1016	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		TTTTCCAGGTCCTGTAGCAAA	0.507000													12	74					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33700320	33700320	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:33700320G>A	uc001uuw.2	-	7	2106	c.1980C>T	c.(1978-1980)GTC>GTT	p.V660V	STARD13_uc001uuu.2_Silent_p.V652V|STARD13_uc001uuv.2_Silent_p.V542V|STARD13_uc001uux.2_Silent_p.V625V|STARD13_uc010tec.1_RNA	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	660					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GAACGCCAAAGACAGCCTTGT	0.493000													36	167					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38153409	38153409	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:38153409T>C	uc001uwo.3	-	13	1866	c.1748A>G	c.(1747-1749)AAC>AGC	p.N583S	POSTN_uc010tet.1_Missense_Mutation_p.N111S|POSTN_uc001uwp.3_Missense_Mutation_p.N583S|POSTN_uc001uwr.2_Missense_Mutation_p.N583S|POSTN_uc001uwq.2_Missense_Mutation_p.N583S|POSTN_uc010teu.1_Missense_Mutation_p.N583S|POSTN_uc010tev.1_Missense_Mutation_p.N583S|POSTN_uc010tew.1_Missense_Mutation_p.N583S|POSTN_uc010tex.1_Missense_Mutation_p.N498S	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	583	FAS1 4.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CTTTAAAATGTTAGTAACACC	0.333000													13	30					0	0	1	0	0
TNFSF11	8600	broad.mit.edu	37	13	43180672	43180672	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:43180672G>A	uc001uyu.2	+	5	721	c.572G>A	c.(571-573)CGG>CAG	p.R191Q	TNFSF11_uc001uyt.2_Missense_Mutation_p.R118Q	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	191	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TACCATGATCGGGGTTGGGCC	0.418000													18	71					0	0	1	0	0
CAB39L	81617	broad.mit.edu	37	13	49951177	49951177	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:49951177G>A	uc001vcw.2	-	3	700	c.202C>T	c.(202-204)CAG>TAG	p.Q68*	CAB39L_uc001vcx.2_Nonsense_Mutation_p.Q68*|CAB39L_uc010adf.2_Nonsense_Mutation_p.Q65*	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	68					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		TGTGCTAGCTGAGCCACTGCT	0.468000													11	77					0	0	1	0	0
LOC220429	220429	broad.mit.edu	37	13	50466962	50466962	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:50466962C>T	uc001vdk.2	+	1	2418	c.2236C>T	c.(2236-2238)CCA>TCA	p.P746S		NR_003268				Homo sapiens CTAGE family, member 5 pseudogene, mRNA (cDNA clone IMAGE:5270026).												0						ACCACGTGCTCCATTTGCAAT	0.527000													12	68					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52549278	52549278	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:52549278G>A	uc001vfw.2	-	2	235	c.78C>T	c.(76-78)ACC>ACT	p.T26T	ATP7B_uc010adv.2_Silent_p.T26T|ATP7B_uc001vfx.2_Silent_p.T26T|ATP7B_uc001vfy.2_Silent_p.T26T|ATP7B_uc010tgt.1_Silent_p.T26T|ATP7B_uc010tgu.1_Silent_p.T26T|ATP7B_uc010tgv.1_Silent_p.T26T|ATP7B_uc010tgw.1_5'UTR	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	26	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CCCAGGCACGGGTAGGCAAAG	0.428000									Wilson_disease				9	47					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52646152	52646152	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:52646152C>T	uc001vge.2	-	21	1992	c.1852G>A	c.(1852-1854)GAA>AAA	p.E618K		NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	618							ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		CATTCATATTCCTTAAACTTC	0.343000													5	18					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53422092	53422092	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:53422092C>T	uc001vhi.2	-	1	683	c.480G>A	c.(478-480)GTG>GTA	p.V160V	PCDH8_uc001vhj.2_Silent_p.V160V	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	160	Extracellular (Potential).|Cadherin 2.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGTCCTCGTCCACCGGCACCT	0.721000													6	22					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299045	58299045	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:58299045C>T	uc001vhq.1	+	4	3989	c.3097C>T	c.(3097-3099)CCC>TCC	p.P1033S	PCDH17_uc010aec.1_Missense_Mutation_p.P1032S|PCDH17_uc001vhr.1_Missense_Mutation_p.P122S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	1033	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCAAGAGGTCCCCTCAGCATC	0.517000													9	68					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61987205	61987205	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:61987205G>A	uc001vid.3	-	2	1391	c.1027C>T	c.(1027-1029)CAG>TAG	p.Q343*	PCDH20_uc010thj.1_Nonsense_Mutation_p.Q343*	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	316	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TCCACAGCCTGGACAGCTGCA	0.423000													18	101					0	0	1	0	0
CLN5	1203	broad.mit.edu	37	13	77575078	77575078	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:77575078A>G	uc001vkc.2	+	4	1226	c.1198A>G	c.(1198-1200)AGA>GGA	p.R400G		NM_006493	NP_006484	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	351					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		TTTACCTATCAGAAACAAAAC	0.303000													4	28					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77807327	77807327	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:77807327G>A	uc001vkf.2	-	19	2678	c.2587C>T	c.(2587-2589)CCA>TCA	p.P863S	MYCBP2_uc010aev.2_Missense_Mutation_p.P267S	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	863					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGCTGTGCTGGATGGGATCTG	0.433000													29	123					0	0	1	0	0
EDNRB	1910	broad.mit.edu	37	13	78492579	78492579	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:78492579C>T	uc001vko.2	-	1	388	c.130G>A	c.(130-132)GAG>AAG	p.E44K	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Missense_Mutation_p.E44K|EDNRB_uc010aez.1_Missense_Mutation_p.E44K|EDNRB_uc001vkp.1_Missense_Mutation_p.E127K|EDNRB_uc010afa.1_Missense_Mutation_p.E44K	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	44	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GTCATTATCTCTGCGGTTTGC	0.627000													13	71					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369299	86369299	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:86369299C>T	uc001vll.1	-	2	1804	c.1345G>A	c.(1345-1347)GAA>AAA	p.E449K	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	449	Extracellular (Potential).|LRR 9.					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GGCAGTATTTCCTTAATGGCA	0.353000													13	26					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96230192	96230192	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:96230192G>A	uc001vmh.2	+	5	672	c.611G>A	c.(610-612)CGG>CAG	p.R204Q	CLDN10_uc001vmg.2_Missense_Mutation_p.R202Q|CLDN10_uc010tii.1_Missense_Mutation_p.R183Q|DZIP1_uc010afn.2_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	204	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			ATGTCTTCTCGGACAAAGTAT	0.388000													10	43					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99520598	99520598	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:99520598G>A	uc001vnt.2	-	28	3035	c.2980C>T	c.(2980-2982)CAT>TAT	p.H994Y	DOCK9_uc001vnw.2_Missense_Mutation_p.H993Y|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Missense_Mutation_p.H994Y|DOCK9_uc010tis.1_Missense_Mutation_p.H993Y|DOCK9_uc010tit.1_Missense_Mutation_p.H994Y|DOCK9_uc010tiq.1_5'Flank|DOCK9_uc010afu.1_Missense_Mutation_p.H840Y	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	994					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					ACTGCATGATGATAGGATGCA	0.383000													5	15					0	0	1	0	0
NALCN	259232	broad.mit.edu	37	13	101997760	101997760	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:101997760C>T	uc001vox.1	-	7	845	c.656G>A	c.(655-657)TGG>TAG	p.W219*	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Nonsense_Mutation_p.W219*|NALCN_uc001vpa.2_Nonsense_Mutation_p.W219*	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	219	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TAAACTATTCCAGGTTACATT	0.378000													9	37					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102344974	102344974	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:102344974G>A	uc001vpb.2	+	8	1274	c.1055G>A	c.(1054-1056)GGA>GAA	p.G352E	ITGBL1_uc010agb.2_Missense_Mutation_p.G303E|ITGBL1_uc001vpc.3_Missense_Mutation_p.G211E	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	352	VII.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TATCCTCCAGGAGATCGCCGG	0.483000													18	77					0	0	1	0	0
EFNB2	1948	broad.mit.edu	37	13	107145727	107145727	+	Silent	SNP	G	A	A	rs144052492	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:107145727G>A	uc001vqi.2	-	5	688	c.663C>T	c.(661-663)CTC>CTT	p.L221L		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	221	Extracellular (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					CTTCGGAACCGAGGATGTTGT	0.483000													26	121					0	0	1	0	0
PROZ	8858	broad.mit.edu	37	13	113826188	113826188	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:113826188G>A	uc001vta.1	+	8	979	c.972G>A	c.(970-972)GGG>GGA	p.G324G	PROZ_uc010agr.1_Silent_p.G346G	NM_003891	NP_003882	P22891	PROZ_HUMAN	protein Z, vitamin K-dependent plasma	324	Peptidase S1.				blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|serine-type endopeptidase activity				0	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.216)	all cancers(43;0.104)		Menadione(DB00170)	TTGTGGAGGGGGAGGAGTGCG	0.632000													13	51					0	0	1	0	0
FAM70B	348013	broad.mit.edu	37	13	114498175	114498175	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr13:114498175G>A	uc001vuh.2	+	4	334	c.307G>A	c.(307-309)GCC>ACC	p.A103T		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	103	Helical; (Potential).					integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			CTTCTGCTGCGCCATCGTGGA	0.547000													9	51					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20295729	20295729	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:20295729G>A	uc010tkv.1	+	1	122	c.122G>A	c.(121-123)GGA>GAA	p.G41E		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCCTCCCTGGAAATTTTCTC	0.448000													33	163					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389398	20389398	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:20389398C>T	uc010tkw.1	+	1	633	c.633C>T	c.(631-633)TTC>TTT	p.F211F		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TAAGCACTTTCTCTCTCTTGG	0.423000													21	91					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20483196	20483196	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:20483196G>A	uc010tky.1	-	1	157	c.157C>T	c.(157-159)CCC>TCC	p.P53S		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TGCAGGCAGGGATCAGAAATT	0.448000													4	18					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692342	20692342	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:20692342C>T	uc010tlc.1	+	1	474	c.474C>T	c.(472-474)TTC>TTT	p.F158F		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		CTGGGAAGTTCTGTATAATTC	0.463000													10	63					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21794020	21794020	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:21794020G>A	uc001wag.2	+	16	2398	c.2398G>A	c.(2398-2400)GAG>AAG	p.E800K	RPGRIP1_uc001wah.2_Missense_Mutation_p.E442K|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001wak.2_Missense_Mutation_p.E275K|RPGRIP1_uc010aim.2_Missense_Mutation_p.E183K|RPGRIP1_uc001wal.2_Missense_Mutation_p.E159K|RPGRIP1_uc001wam.2_Missense_Mutation_p.E117K	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	800					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		ACCTCAGAACGAGCTGTGGAT	0.502000													9	36					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22134093	22134093	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:22134093C>T	uc010tmd.1	+	1	797	c.797C>T	c.(796-798)TCC>TTC	p.S266F		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		ACCAGCTTCTCCATTGACAAG	0.507000													7	29					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23531415	23531415	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:23531415G>A	uc001wit.3	-	16	3563	c.3235C>T	c.(3235-3237)CCC>TCC	p.P1079S	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.P321S|ACIN1_uc001wiq.3_Missense_Mutation_p.P321S|ACIN1_uc001wir.3_Missense_Mutation_p.P352S|ACIN1_uc001wis.3_Missense_Mutation_p.P760S|ACIN1_uc010akg.2_Missense_Mutation_p.P1066S	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1079					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		AGGAATTTGGGATTGGACTGG	0.532000													35	163					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23874032	23874032	+	Splice_Site	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:23874032C>T	uc001wjv.2	-	7	598	c.531_splice	c.e7-1	p.T177_splice	MYH6_uc010akp.1_Splice_Site_p.T177_splice	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6						adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGATTCTCCCCTGGGGGCCAC	0.567000													21	74					0	0	1	0	0
DHRS2	10202	broad.mit.edu	37	14	24109021	24109021	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:24109021G>A	uc001wkt.3	+	4	784	c.337G>A	c.(337-339)GGC>AGC	p.G113S	DHRS2_uc010aku.1_Missense_Mutation_p.G113S|DHRS2_uc001wku.3_Missense_Mutation_p.G113S|DHRS2_uc010akv.2_RNA|DHRS2_uc001wkv.3_Missense_Mutation_p.G113S	NM_182908	NP_878912	Q13268	DHRS2_HUMAN	dehydrogenase/reductase member 2 isoform 1	91					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00659)		GCACTGTGGGGGCGTCGACTT	0.632000													10	61					0	0	1	0	0
TGM1	7051	broad.mit.edu	37	14	24730925	24730925	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:24730925G>A	uc001wod.2	-	3	608	c.484C>T	c.(484-486)CGC>TGC	p.R162C	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	162					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	AGGGTGATGCGATCAGAGGAT	0.572000													29	137					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25044523	25044523	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:25044523C>T	uc001wpq.2	-	2	188	c.151G>A	c.(151-153)GGG>AGG	p.G51R		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	51	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		ACCAGGAACCCTCCACATCTG	0.607000													28	136					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32562058	32562058	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:32562058C>T	uc001wrl.2	+	2	2422	c.2183C>T	c.(2182-2184)CCT>CTT	p.P728L	ARHGAP5_uc001wrm.2_Missense_Mutation_p.P728L|ARHGAP5_uc001wrn.2_Missense_Mutation_p.P728L|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	728					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTGCAATGTCCTTTTGTAGAT	0.383000													17	65					0	0	1	0	0
NFKBIA	4792	broad.mit.edu	37	14	35871823	35871823	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:35871823T>C	uc001wtf.3	-	5	793	c.683A>G	c.(682-684)CAA>CGA	p.Q228R	NFKBIA_uc001wte.3_Missense_Mutation_p.Q138R|NFKBIA_uc001wtg.3_Intron|NFKBIA_uc010amo.2_RNA	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	228	ANK 5.				anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		GTCAGGATTTTGCAGGTCCAC	0.532000													26	83					0	0	1	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724651	38724651	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:38724651G>A	uc001wum.1	-	1	924	c.577C>T	c.(577-579)CGC>TGC	p.R193C		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	193	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		AAGGGCGCGCGATAGCTCAAG	0.542000													19	70					0	0	1	0	0
MIA2	117153	broad.mit.edu	37	14	39716206	39716206	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:39716206C>T	uc001wux.2	+	4	622	c.428C>T	c.(427-429)CCT>CTT	p.P143L	MIA2_uc010amy.1_Missense_Mutation_p.P74L	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	143						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		AATATATATCCTTATGAAGAA	0.294000													4	29					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44976126	44976126	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:44976126G>A	uc001wvn.2	-	1	374	c.65C>T	c.(64-66)TCA>TTA	p.S22L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	22						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		GGGGCTAGATGATTTTGGTAT	0.418000													48	150					0	0	1	0	0
RPL10L	140801	broad.mit.edu	37	14	47120418	47120418	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:47120418C>T	uc001wwg.2	-	1	611	c.522G>A	c.(520-522)ACG>ACA	p.T174T		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	174					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						CATTAAACTTCGTGAAGCCCC	0.507000													25	119					0	0	1	0	0
GNG2	54331	broad.mit.edu	37	14	52433367	52433367	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:52433367C>T	uc001wzi.2	+	4	707	c.178C>T	c.(178-180)CCG>TCG	p.P60S	GNG2_uc001wzh.2_RNA|GNG2_uc010aoc.1_RNA|GNG2_uc001wzj.2_RNA|GNG2_uc001wzk.2_Missense_Mutation_p.P60S	NM_053064	NP_444292	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein),	60					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity				0	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	TTCAGAAAACCCGTTTAGGGA	0.522000													21	84					0	0	1	0	0
PTGDR	5729	broad.mit.edu	37	14	52735319	52735319	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:52735319C>T	uc001wzq.2	+	1	889	c.787C>T	c.(787-789)CAC>TAC	p.H263Y		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	263	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	GGAGCTGGATCACCTCCTGCT	0.687000													51	200					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57938121	57938121	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:57938121G>A	uc001xcy.2	-	6	986	c.843C>T	c.(841-843)ACC>ACT	p.T281T	C14orf105_uc010trl.1_Silent_p.T321T|C14orf105_uc010trm.1_Silent_p.T192T|C14orf105_uc010trn.1_Silent_p.T192T|C14orf105_uc001xcz.2_Silent_p.T280T	NM_018168	NP_060638	Q9NVL8	CN105_HUMAN	hypothetical protein LOC55195	281											0						TCTCTGTCCTGGTCCTCACCA	0.448000													15	53					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58060680	58060680	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:58060680C>T	uc001xdb.1	-	2	374	c.374G>A	c.(373-375)AGA>AAA	p.R125K	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TCTCTCAACTCTGTGTCCACA	0.453000													3	38					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58832826	58832826	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:58832826C>T	uc001xdp.2	+	22	3655	c.3401C>T	c.(3400-3402)CCA>CTA	p.P1134L	ARID4A_uc001xdo.2_Intron|ARID4A_uc001xdq.2_Intron	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	1134					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						GTATCTAAGCCACAGAAACTT	0.383000													62	233					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58937421	58937421	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:58937421C>T	uc001xdv.3	+	16	2578	c.2305C>T	c.(2305-2307)CCT>TCT	p.P769S	KIAA0586_uc010trr.1_Missense_Mutation_p.P886S|KIAA0586_uc001xdt.3_Missense_Mutation_p.P801S|KIAA0586_uc001xdu.3_Missense_Mutation_p.P830S|KIAA0586_uc010trs.1_Missense_Mutation_p.P760S|KIAA0586_uc010trt.1_Missense_Mutation_p.P705S|KIAA0586_uc010tru.1_Missense_Mutation_p.P705S	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein	769										ovary(1)	1						ATCTCTTCCTCCTGTGCAAAC	0.343000													6	22					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62463026	62463026	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:62463026G>A	uc001xfu.1	+	1	486	c.289G>A	c.(289-291)GAT>AAT	p.D97N	SYT16_uc010tsd.1_Missense_Mutation_p.D97N	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	97										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTGTAATAGTGATTTGCAGGA	0.433000													12	69					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63468140	63468140	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:63468140T>C	uc001xfx.2	-	4	393	c.342A>G	c.(340-342)ATA>ATG	p.I114M	KCNH5_uc001xfy.2_Missense_Mutation_p.I114M|KCNH5_uc001xfz.1_Missense_Mutation_p.I56M|KCNH5_uc001xga.2_Missense_Mutation_p.I56M	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	114	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GTTCATTTCTTATTGGTGCAA	0.403000													5	37					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65208940	65208940	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:65208940C>T	uc001xho.1	+	16	2974	c.2705C>T	c.(2704-2706)CCA>CTA	p.P902L	PLEKHG3_uc001xhn.1_Missense_Mutation_p.P846L|PLEKHG3_uc001xhp.2_Missense_Mutation_p.P1023L|PLEKHG3_uc010aqh.1_Missense_Mutation_p.P444L|PLEKHG3_uc001xhq.1_Missense_Mutation_p.P407L	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	902					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CTGGTGGCCCCACTGCACCCC	0.667000													9	48					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65240022	65240022	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:65240022C>T	uc001xht.2	-	24	5148	c.5094G>A	c.(5092-5094)GAG>GAA	p.E1698E	SPTB_uc001xhr.2_Silent_p.E1698E|SPTB_uc001xhs.2_Silent_p.E1698E|SPTB_uc001xhu.2_Silent_p.E1698E|SPTB_uc010aqi.2_Silent_p.E359E	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1698	Spectrin 14.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GGTCGTCGGTCTCCCGCTTGA	0.572000													14	76					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65262322	65262322	+	Silent	SNP	G	A	A	rs146670683		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:65262322G>A	uc001xht.2	-	11	1431	c.1377C>T	c.(1375-1377)GCC>GCT	p.A459A	SPTB_uc001xhr.2_Silent_p.A459A|SPTB_uc001xhs.2_Silent_p.A459A|SPTB_uc001xhu.2_Silent_p.A459A	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	459	Spectrin 2.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TCTTCTTGGCGGCCTCCACAG	0.602000													14	72					0	0	1	0	0
FUT8	2530	broad.mit.edu	37	14	66082996	66082996	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:66082996C>T	uc001xin.2	+	5	1584	c.387C>T	c.(385-387)TTC>TTT	p.F129F	FUT8_uc001xio.2_Silent_p.F129F|FUT8_uc010tsp.1_5'UTR|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Silent_p.F129F|FUT8_uc001xiq.2_5'UTR	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	129	Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TCTGGTTTTTCCTACAGAGTG	0.378000													16	44					0	0	1	0	0
DCAF5	8816	broad.mit.edu	37	14	69521190	69521190	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:69521190G>A	uc001xkp.2	-	9	2432	c.2213C>T	c.(2212-2214)CCT>CTT	p.P738L	DCAF5_uc001xkq.2_Missense_Mutation_p.P737L	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	738						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						GGGAGTTCTAGGAGTCTCTTC	0.547000													16	97					0	0	1	0	0
GALNTL1	57452	broad.mit.edu	37	14	69795192	69795192	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:69795192G>A	uc010aqu.1	+	6	687	c.594G>A	c.(592-594)GGG>GGA	p.G198G	GALNTL1_uc001xla.1_Silent_p.G198G|GALNTL1_uc001xlb.1_Silent_p.G198G	NM_020692	NP_065743	Q8N428	GLTL1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	198	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(1)|central_nervous_system(1)	2				all cancers(60;0.00793)|BRCA - Breast invasive adenocarcinoma(234;0.0174)|OV - Ovarian serous cystadenocarcinoma(108;0.0656)		GAGTGCGTGGGGCGGACGTGG	0.627000													38	192					0	0	1	0	0
SLC10A1	6554	broad.mit.edu	37	14	70263654	70263654	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:70263654G>A	uc001xlr.2	-	1	353	c.219C>T	c.(217-219)CCC>CCT	p.P73P		NM_003049	NP_003040	Q14973	NTCP_HUMAN	solute carrier family 10, member 1	73	Helical; (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(1)	1				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		AGGCCGTGAGGGGCATGATGC	0.577000													13	53					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70712832	70712832	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:70712832C>T	uc010ttg.1	-	1	1687	c.1036G>A	c.(1036-1038)GAG>AAG	p.E346K		NR_003951				SubName: Full=ADAM21-like protein;												0						CCAAAAATCTCCCTGCAATGC	0.423000													4	65					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713546	70713546	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:70713546C>T	uc010ttg.1	-	1	973	c.322G>A	c.(322-324)GAT>AAT	p.D108N		NR_003951				SubName: Full=ADAM21-like protein;												0						TGAGAGAAATCATTTAGGATC	0.358000													7	41					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924332	70924332	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:70924332C>T	uc001xmd.2	+	1	116	c.116C>T	c.(115-117)TCC>TTC	p.S39F		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	39					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		CATTTCACTTCCCCGGAAGTG	0.552000													21	109					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70925762	70925762	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:70925762G>A	uc001xmd.2	+	1	1546	c.1546G>A	c.(1546-1548)GAG>AAG	p.E516K		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	516	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCATTGCAGGGAGATTTTTGG	0.423000													11	80					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72202026	72202026	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:72202026G>A	uc001xms.2	+	20	5452	c.5104G>A	c.(5104-5106)GAA>AAA	p.E1702K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.E1681K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.E1681K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.E1702K|SIPA1L1_uc010ttm.1_Missense_Mutation_p.E1156K|SIPA1L1_uc001xmw.2_Missense_Mutation_p.E467K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1702					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TGCTAGTGATGAAAACCATCG	0.498000													28	184					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73989524	73989524	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:73989524G>A	uc010tub.1	-	3	655	c.333C>T	c.(331-333)GCC>GCT	p.A111A	HEATR4_uc010tua.1_Silent_p.A64A	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TCTGAGGCCGGGCCTTCCTGA	0.532000													13	55					0	0	1	0	0
HEATR4	399671	broad.mit.edu	37	14	73989833	73989833	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:73989833C>T	uc010tub.1	-	3	346	c.24G>A	c.(22-24)AAG>AAA	p.K8K	HEATR4_uc010tua.1_5'UTR	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		GGAGAAAGGTCTTTCCCTTCT	0.532000													3	9					0	0	1	0	0
ZNF410	57862	broad.mit.edu	37	14	74360528	74360528	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:74360528C>T	uc001xoz.1	+	3	244	c.62C>T	c.(61-63)TCC>TTC	p.S21F	ZNF410_uc001xoy.1_RNA|ZNF410_uc010ary.1_RNA|ZNF410_uc010tuf.1_RNA|ZNF410_uc010tug.1_5'UTR|ZNF410_uc010tuh.1_Missense_Mutation_p.S21F|ZNF410_uc010tui.1_RNA|ZNF410_uc010arz.1_Missense_Mutation_p.S21F|ZNF410_uc001xpa.1_5'UTR|ZNF410_uc001xpb.1_Missense_Mutation_p.S21F|ZNF410_uc001xpc.1_5'UTR	NM_021188	NP_067011	Q86VK4	ZN410_HUMAN	zinc finger protein 410	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00369)		CAGAATACGTCCATCCCATTG	0.438000													20	71					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75276419	75276419	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:75276419C>T	uc001xqj.3	+	7	4982	c.4858C>T	c.(4858-4860)CCT>TCT	p.P1620S	YLPM1_uc001xql.3_RNA|YLPM1_uc001xqm.1_Missense_Mutation_p.P103S	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CATTCCCCCTCCTGGCCCAGT	0.493000													15	44					0	0	1	0	0
ANGEL1	23357	broad.mit.edu	37	14	77272972	77272972	+	Silent	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:77272972T>C	uc001xsv.2	-	5	1280	c.1167A>G	c.(1165-1167)GCA>GCG	p.A389A	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	389										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		TATGGGTATTTGCCACACACA	0.567000													19	69					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86088433	86088433	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:86088433T>A	uc001xvr.2	+	2	1342	c.575T>A	c.(574-576)ATT>AAT	p.I192N	FLRT2_uc010atd.2_Missense_Mutation_p.I192N	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	192	Extracellular (Potential).|LRR 6.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GAAAATCGAATTGCTGTCATA	0.498000													27	68					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88707124	88707124	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:88707124C>T	uc001xwo.2	-	3	885	c.428G>A	c.(427-429)GGA>GAA	p.G143E	KCNK10_uc001xwm.2_Missense_Mutation_p.G148E|KCNK10_uc001xwn.2_Missense_Mutation_p.G148E	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	143					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GGAAGAGTTTCCTATTGGACT	0.418000													11	58					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88938715	88938716	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:88938715_88938716GT>AA	uc001xwv.3	-	15	3074_3075	c.2743_2744AC>TT	c.(2743-2745)ACA>TTA	p.T915L	PTPN21_uc010twc.1_Missense_Mutation_p.T711L	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	915	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						GAGTCGTGCTGTTGAGCACTCC	0.381000													6	53					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88970769	88970769	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:88970769C>T	uc001xwv.3	-	6	918	c.587G>A	c.(586-588)AGA>AAA	p.R196K	PTPN21_uc010twc.1_5'UTR|PTPN21_uc010atf.1_Missense_Mutation_p.R196K	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	196	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TTAGAGTTACCTGTATTTCTG	0.289000													17	65					0	0	1	0	0
C14orf159	80017	broad.mit.edu	37	14	91639693	91639693	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:91639693C>T	uc001xzb.2	+	8	1270	c.502C>T	c.(502-504)CCC>TCC	p.P168S	C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Missense_Mutation_p.P173S|C14orf159_uc001xyx.2_Missense_Mutation_p.P168S|C14orf159_uc001xyw.2_Missense_Mutation_p.P173S|C14orf159_uc001xzc.2_Missense_Mutation_p.P168S|C14orf159_uc001xza.2_Missense_Mutation_p.P173S|C14orf159_uc001xyv.2_Missense_Mutation_p.P173S|C14orf159_uc001xyz.2_Missense_Mutation_p.P44S|C14orf159_uc001xze.2_Missense_Mutation_p.P168S	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	168						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		CACGATGAGGCCCATTCCCAA	0.532000											OREG0022869	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	58					0	0	1	0	0
FBLN5	10516	broad.mit.edu	37	14	92349320	92349320	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:92349320C>T	uc001xzx.3	-	8	1313	c.840G>A	c.(838-840)CTG>CTA	p.L280L	FBLN5_uc010aud.2_Silent_p.L285L|FBLN5_uc010aue.2_Silent_p.L321L	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	280	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				GGTTGTCATCCAGCAGGATGT	0.572000													8	67					0	0	1	0	0
TCL1B	9623	broad.mit.edu	37	14	96157189	96157189	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:96157189G>A	uc001yez.2	+	2	321	c.279G>A	c.(277-279)GGG>GGA	p.G93G	TCL1B_uc001yew.2_RNA|TCL1B_uc001yex.2_RNA|TCL1B_uc010avj.2_RNA|TCL1B_uc001yfa.2_Silent_p.G93G	NM_004918	NP_004909	O95988	TCL1B_HUMAN	T-cell leukemia/lymphoma 1B	93										ovary(1)	1		all_cancers(154;0.103)		COAD - Colon adenocarcinoma(157;0.205)|Epithelial(152;0.248)		TCTACCCCGGGAGGAAGTACC	0.612000													18	89					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99641066	99641066	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:99641066G>A	uc001yga.2	-	4	2374	c.2107C>T	c.(2107-2109)CCG>TCG	p.P703S	BCL11B_uc001ygb.2_Missense_Mutation_p.P632S	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	703						nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TTCTCGGACGGGATGAGCGCG	0.706000			T	TLX3	T-ALL								7	30					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100118902	100118902	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:100118902G>A	uc010avs.2	+	2	662	c.597G>A	c.(595-597)ATG>ATA	p.M199I	HHIPL1_uc001ygl.1_Missense_Mutation_p.M199I	NM_001127258	NP_001120730	Q96JK4	HIPL1_HUMAN	HHIP-like protein 1 isoform a	199					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			skin(2)	2		Melanoma(154;0.128)				CCGTGGCCATGGTCCATGCCA	0.677000													17	35					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105208283	105208283	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:105208283G>A	uc001ypd.2	+	9	966	c.892G>A	c.(892-894)GTG>ATG	p.V298M	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.V341M|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	298					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	GTATGGCGTGGTGAAAGCCTA	0.642000													66	199					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106237046	106237046	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:106237046G>A	uc010tyt.1	-	3612		c.57445C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysh.1_RNA|uc001ysi.1_RNA					Parts of antibodies, mostly variable regions.												0						CACCAAGTGGGGTTTTGAGCT	0.572000													28	160					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106573536	106573536	+	RNA	SNP	A	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:106573536A>C	uc010tyt.1	-	1362		c.28989T>G								Parts of antibodies, mostly variable regions.												0						GACACTGGACACCTGCAAACA	0.517000													34	156					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106641921	106641921	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:106641921C>T	uc010tyt.1	-	1021		c.24080G>A								Parts of antibodies, mostly variable regions.												0						CCTGGTTTCTCTCTCAGCCCT	0.582000													10	44					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106725137	106725137	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:106725137C>T	uc010tyt.1	-	589		c.18377G>A								Parts of antibodies, mostly variable regions.												0						CCGCTGATTTCCCCCCCATCG	0.587000													11	120					0	0	1	0	0
ADAM6	8755	broad.mit.edu	37	14	106805666	106805666	+	Splice_Site	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr14:106805666G>A	uc010tyt.1	-	359		c.13625_splice	c.e359-1		uc001ysw.1_5'Flank					Parts of antibodies, mostly variable regions.												0						GGAGGTCCAGGACTCTCAGAA	0.498000													5	59					0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21936638	21936638	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:21936638G>A	uc010tzj.1	-	1		c.4102C>T				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						CTAGTTTCAGGAAAAGATGCT	0.403000													14	242					0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21936679	21936679	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:21936679C>T	uc010tzj.1	-	1		c.4061G>A				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						CCCCTTTTTTCCACATCTGTT	0.403000													13	178					0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21937762	21937762	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:21937762G>A	uc010tzj.1	-	1		c.2978C>T				NR_027053				Homo sapiens mRNA for p21-activated kinase 2 variant protein.												0						ATCCAGCACAGCCTGAGGATT	0.463000													5	99					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22368968	22368968	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:22368968C>T	uc010tzu.1	+	1	393	c.393C>T	c.(391-393)CAC>CAT	p.H131H	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GACCCCTCCACTATGCTACCA	0.507000													10	152					0	0	1	0	0
Unknown	0	broad.mit.edu	37	15	22440582	22440582	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:22440582C>T	uc001yug.2	-	1	284	c.265G>A	c.(265-267)GAG>AAG	p.E89K						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).																		CGAACCAGCTCGTTATTAGAT	0.517000													10	72					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24921643	24921643	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:24921643G>A	uc001ywo.2	+	1	1103	c.629G>A	c.(628-630)GGA>GAA	p.G210E		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	210					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTCTGGAGGGAAATGTCTAC	0.612000													8	24					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24923805	24923805	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:24923805C>T	uc001ywo.2	+	1	3265	c.2791C>T	c.(2791-2793)CCT>TCT	p.P931S		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	931					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CTTAACATCTCCTTCAGTCCA	0.488000													14	97					0	0	1	0	0
C15orf2	23742	broad.mit.edu	37	15	24924404	24924404	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:24924404G>A	uc001ywo.2	+	1	3864	c.3390G>A	c.(3388-3390)GAG>GAA	p.E1130E		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	1130					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CATGGACAGAGAGAAAATTCT	0.473000													29	128					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28259931	28259931	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:28259931G>A	uc001zbh.3	-	9	1145	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	OCA2_uc010ayv.2_Silent_p.I345I	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	345	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CCTCAAATATGATCAGCGCGT	0.577000									Oculocutaneous_Albinism				9	32					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33858887	33858887	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:33858887C>T	uc001zhi.2	+	12	1225	c.1155C>T	c.(1153-1155)CTC>CTT	p.L385L	RYR3_uc010bar.2_Silent_p.L385L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	385	Cytoplasmic (By similarity).|MIR 5.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGTCATACTCCATCAGGAAG	0.517000													33	92					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33895503	33895503	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:33895503G>A	uc001zhi.2	+	18	2172	c.2102G>A	c.(2101-2103)GGA>GAA	p.G701E	RYR3_uc010bar.2_Missense_Mutation_p.G701E	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	701	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAAGGATGGGGAGGCAATGGT	0.547000													41	172					0	0	1	0	0
MEIS2	4212	broad.mit.edu	37	15	37184528	37184528	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:37184528G>A	uc001zjr.2	-	12	2317	c.1280C>T	c.(1279-1281)TCA>TTA	p.S427L	MEIS2_uc001zjl.2_3'UTR|MEIS2_uc010ucj.1_Missense_Mutation_p.S407L|MEIS2_uc001zjm.2_3'UTR|MEIS2_uc001zjn.2_3'UTR|MEIS2_uc001zjo.2_3'UTR|MEIS2_uc001zjp.2_3'UTR|MEIS2_uc001zjs.2_Missense_Mutation_p.S420L|MEIS2_uc001zju.2_3'UTR|MEIS2_uc001zjt.2_Missense_Mutation_p.S420L|MEIS2_uc001zjj.2_Missense_Mutation_p.S123L|MEIS2_uc001zjk.2_Missense_Mutation_p.S116L	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	427					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TGGCAAATATGAATGCATTGG	0.537000													63	316					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42041469	42041469	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:42041469C>T	uc010ucy.1	+	17	5845	c.5664C>T	c.(5662-5664)TCC>TCT	p.S1888S	MGA_uc010ucz.1_Silent_p.S1679S|MGA_uc010uda.1_Silent_p.S504S|MGA_uc001zoi.2_Silent_p.S102S	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1849						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CATTGCTTTCCTCTGGAGCTA	0.453000													9	32					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43363110	43363110	+	Missense_Mutation	SNP	G	A	A	rs145854171		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:43363110G>A	uc001zqq.2	-	5	608	c.542C>T	c.(541-543)CCG>CTG	p.P181L	UBR1_uc010udk.1_Missense_Mutation_p.P181L	NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	181					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		TTCATTCAACGGACAGCGTGA	0.328000													18	59					0	0	1	0	0
TGM5	9333	broad.mit.edu	37	15	43527773	43527773	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:43527773G>A	uc001zrd.1	-	10	1616	c.1608C>T	c.(1606-1608)TTC>TTT	p.F536F	TGM5_uc001zrc.1_Silent_p.F193F|TGM5_uc001zre.1_Silent_p.F454F	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	536					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TGAGGTCCTTGAACTGGGAGG	0.557000													15	71					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45436415	45436415	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:45436415C>T	uc001zus.1	+	18	2464	c.2118C>T	c.(2116-2118)ATC>ATT	p.I706I	DUOX1_uc001zut.1_Silent_p.I706I|DUOX1_uc010bee.1_Silent_p.I86I	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	706	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TGCTCAAGATCCCCAAGGAGT	0.622000													11	73					0	0	1	0	0
FGF7	2252	broad.mit.edu	37	15	49775435	49775435	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:49775435G>A	uc001zxn.2	+	3	903	c.374G>A	c.(373-375)GGA>GAA	p.G125E	C15orf33_uc001zxl.2_Intron|C15orf33_uc001zxm.2_Intron	NM_002009	NP_002000	P21781	FGF7_HUMAN	fibroblast growth factor 7 precursor	125					actin cytoskeleton reorganization|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|protein localization at cell surface|secretion by lung epithelial cell involved in lung growth		chemoattractant activity|growth factor activity				0		all_lung(180;0.00391)		all cancers(107;3.61e-08)|GBM - Glioblastoma multiforme(94;4.06e-05)	Palifermin(DB00039)	AACAAGGAAGGAAAACTCTAT	0.343000													17	52					0	0	1	0	0
SLC27A2	11001	broad.mit.edu	37	15	50497527	50497527	+	Silent	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:50497527T>G	uc001zxw.2	+	4	1171	c.939T>G	c.(937-939)GGT>GGG	p.G313G	SLC27A2_uc010bes.2_Silent_p.G260G|SLC27A2_uc001zxx.2_Silent_p.G78G	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	313	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		AGTATATCGGTGAACTGCTTC	0.428000													16	104					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50534519	50534519	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:50534519G>A	uc001zxz.2	-	12	2033	c.1927C>T	c.(1927-1929)CCT>TCT	p.P643S	HDC_uc001zxy.2_Missense_Mutation_p.P386S|HDC_uc010uff.1_Missense_Mutation_p.P610S	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	643					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	CTGCATTCAGGAAAGCTGGGG	0.398000													16	79					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55916539	55916539	+	Splice_Site	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:55916539C>T	uc002adg.2	-	18	3141	c.3093_splice	c.e18+1	p.K1031_splice		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor						multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		CAGCTCAGTACCTTTGCATCA	0.418000													20	90					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57910263	57910263	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:57910263G>A	uc002aei.2	+	3	314	c.195G>A	c.(193-195)AGG>AGA	p.R65R	GCOM1_uc002aej.2_Silent_p.R65R|GCOM1_uc002aek.2_RNA|GCOM1_uc002ael.2_RNA|GCOM1_uc002aem.2_Silent_p.R65R|GCOM1_uc002aeq.2_RNA|GCOM1_uc002aen.2_RNA|GCOM1_uc010bfy.2_RNA|GCOM1_uc002aeo.2_Silent_p.R65R|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_RNA	NM_001018100	NP_001018110	P0CAP1	GCOM1_HUMAN	GRINL1A upstream protein isoform 7	65					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				ovary(1)	1						AACCTACCAGGAAACTTCCTC	0.413000													10	50					0	0	1	0	0
BNIP2	663	broad.mit.edu	37	15	59964837	59964837	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:59964837T>C	uc010uhc.1	-	6	940	c.937A>G	c.(937-939)AAA>GAA	p.K313E	BNIP2_uc010uhb.1_Missense_Mutation_p.K254E	NM_004330	NP_004321	Q12982	BNIP2_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 2	192	CRAL-TRIO.				anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			ovary(1)	1						TATACTTACTTAAAAAGATTG	0.294000													14	58					0	0	1	0	0
NARG2	79664	broad.mit.edu	37	15	60720806	60720806	+	Missense_Mutation	SNP	A	G	G	rs148318569		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:60720806A>G	uc002agp.2	-	15	2877	c.2642T>C	c.(2641-2643)GTT>GCT	p.V881A	NARG2_uc002ago.2_Missense_Mutation_p.V744A	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	881						nucleus				ovary(1)|lung(1)	2						TGTCCTAGTAACTTTTCCATC	0.438000													9	39					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62256091	62256091	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:62256091C>T	uc002agz.2	-	32	3348	c.3274G>A	c.(3274-3276)GCT>ACT	p.A1092T	VPS13C_uc002aha.2_Missense_Mutation_p.A1049T|VPS13C_uc002ahb.1_Missense_Mutation_p.A1092T|VPS13C_uc002ahc.1_Missense_Mutation_p.A1049T	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	1092					protein localization					ovary(2)	2						ACACAGAAAGCATTCAACTTG	0.358000													14	38					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63102156	63102157	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:63102156_63102157GG>AA	uc002alb.3	+	49	6696_6697	c.6696_6697GG>AA	c.(6694-6699)GAGGTG>GAAATG	p.V2233M	TLN2_uc002alc.3_Missense_Mutation_p.V626M	NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	2233					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TCAGTGACGAGGTGAGAACCAG	0.550000													9	58					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65772707	65772707	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:65772707C>T	uc002aov.2	-	10	2775	c.1197G>A	c.(1195-1197)CAG>CAA	p.Q399Q	DPP8_uc002aow.2_Silent_p.Q399Q|DPP8_uc010uiv.1_RNA|DPP8_uc002aox.2_Silent_p.Q383Q|DPP8_uc002aoy.2_Silent_p.Q399Q|DPP8_uc002aoz.2_Silent_p.Q383Q|DPP8_uc010bhj.2_Silent_p.Q399Q|DPP8_uc002apa.2_Silent_p.Q296Q|DPP8_uc010bhk.1_Intron	NM_130434	NP_569118	Q6V1X1	DPP8_HUMAN	dipeptidyl peptidase 8 isoform 1	399					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity			ovary(1)	1						GTAGGCGAGTCTGGGAGCGAT	0.383000													7	43					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68617562	68617562	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:68617562C>T	uc002ari.2	-	18	2316	c.2229G>A	c.(2227-2229)GTG>GTA	p.V743V	ITGA11_uc010bib.2_Silent_p.V743V	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	743	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	TCACTGGCTTCACGTAGTCAG	0.582000													18	69					0	0	1	0	0
GLCE	26035	broad.mit.edu	37	15	69561363	69561363	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:69561363T>C	uc002ary.1	+	5	1862	c.1634T>C	c.(1633-1635)CTT>CCT	p.L545P		NM_015554	NP_056369	O94923	GLCE_HUMAN	D-glucuronyl C5-epimerase	545	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process|heparin biosynthetic process	Golgi membrane|integral to membrane	UDP-glucuronate 5'-epimerase activity			ovary(2)	2						ATGGAATCTCTTAAAGCCATG	0.463000													19	80					0	0	1	0	0
SH2D7	646892	broad.mit.edu	37	15	78390807	78390807	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:78390807G>A	uc010blb.1	+	4	514	c.514G>A	c.(514-516)GCA>ACA	p.A172T		NM_001101404	NP_001094874	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	172											0						ACCTGCCACGGCATTCCTCAC	0.607000													9	57					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79382667	79382667	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:79382667C>T	uc002beq.2	-	1	549	c.174G>A	c.(172-174)TCG>TCA	p.S58S	RASGRF1_uc002bep.2_Silent_p.S58S|RASGRF1_uc002ber.3_Silent_p.S58S	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	58	PH 1.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GCCGCGAGCTCGAGTCGCTCT	0.637000													14	64					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79382829	79382829	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:79382829C>T	uc002beq.2	-	1	387	c.12G>A	c.(10-12)GGG>GGA	p.G4G	RASGRF1_uc002bep.2_Silent_p.G4G|RASGRF1_uc002ber.3_Silent_p.G4G	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	4					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TCAGCCGGATCCCCTTCTGCA	0.662000													50	259					0	0	1	0	0
EFTUD1	79631	broad.mit.edu	37	15	82450160	82450161	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:82450160_82450161GG>AA	uc002bgt.1	-	17	2092_2093	c.1923_1924CC>TT	c.(1921-1926)AACCAG>AATTAG	p.Q642*	EFTUD1_uc002bgs.1_Nonsense_Mutation_p.Q13*|EFTUD1_uc002bgu.1_Nonsense_Mutation_p.Q591*	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	642					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						GGATCAGCCTGGTTTAACAGTT	0.396000													14	53					0	0	1	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85147260	85147260	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:85147260C>T	uc002bkr.2	+	2	328	c.102C>T	c.(100-102)ATC>ATT	p.I34I	ZSCAN2_uc002bkp.2_Silent_p.I34I|ZSCAN2_uc002bkq.2_Silent_p.I34I|ZSCAN2_uc010bmz.1_Silent_p.I33I|ZSCAN2_uc010bna.2_Intron|ZSCAN2_uc010uox.1_Silent_p.I33I|ZSCAN2_uc010uoy.1_Silent_p.I33I|ZSCAN2_uc010uoz.1_Silent_p.I33I	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	34					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CCACCATGATCCTGGAGGATG	0.612000													14	78					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86124839	86124839	+	Missense_Mutation	SNP	C	G	G	rs145657332		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:86124839C>G	uc002blv.1	+	7	3710	c.3540C>G	c.(3538-3540)GAC>GAG	p.D1180E	AKAP13_uc002blt.1_Missense_Mutation_p.D1180E|AKAP13_uc002blu.1_Missense_Mutation_p.D1180E|AKAP13_uc010bne.1_5'Flank	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	1180					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CCCAAATAGACGATGAAGCAC	0.567000													11	39					0	0	1	0	0
AGBL1	123624	broad.mit.edu	37	15	87097661	87097661	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:87097661A>G	uc002blz.1	+	20	2829	c.2749A>G	c.(2749-2751)AAA>GAA	p.K917E		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	917					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TCTCGTGGAGAAATCTCGAGC	0.507000													2	4					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88420258	88420258	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:88420258C>T	uc002bme.1	-	19	2590	c.2428G>A	c.(2428-2430)GAA>AAA	p.E810K	NTRK3_uc002bmh.2_Missense_Mutation_p.E788K|NTRK3_uc002bmf.1_Missense_Mutation_p.E796K	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	810	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGCTGTGGTTCCCTCTGCCAG	0.542000			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			20	81					0	0	1	0	0
HAPLN3	145864	broad.mit.edu	37	15	89424760	89424760	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:89424760C>T	uc002bnc.2	-	3	449	c.321G>A	c.(319-321)CTG>CTA	p.L107L	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Silent_p.L169L	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	107	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					AGCGGTGCCTCAGCCCGATGG	0.657000													19	97					0	0	1	0	0
TTLL13	440307	broad.mit.edu	37	15	90799107	90799107	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:90799107C>T	uc002bpd.1	+	5	826	c.538C>T	c.(538-540)CTC>TTC	p.L180F	TTLL13_uc002bpe.1_Intron	NM_001029964	NP_001025135	A6NNM8	TTL13_HUMAN	tubulin tyrosine ligase-like family, member 13	180	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			CACCTGGTGCCTCCCCGCAGA	0.552000													78	449					0	0	1	0	0
SV2B	9899	broad.mit.edu	37	15	91769536	91769536	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:91769536C>T	uc002bqv.2	+	1	434	c.43C>T	c.(43-45)CCC>TCC	p.P15S	SV2B_uc002bqt.2_Missense_Mutation_p.P15S|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	15	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGGCTATGCTCCCAGTGATGG	0.517000													22	57					0	0	1	0	0
CHD2	1106	broad.mit.edu	37	15	93557990	93557990	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:93557990C>T	uc002bsp.2	+	37	5332	c.4757C>T	c.(4756-4758)TCC>TTC	p.S1586F	CHD2_uc002bso.1_Missense_Mutation_p.S1586F	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1586					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GCCTCAGGCTCCAGCCGGGAC	0.512000													25	113					0	0	1	0	0
SYNM	23336	broad.mit.edu	37	15	99672051	99672051	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:99672051G>A	uc002bup.2	+	6	3606	c.3486G>A	c.(3484-3486)GCG>GCA	p.A1162A	SYNM_uc002buo.2_Intron|SYNM_uc002buq.2_Intron	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1162	Tail.|Interaction with TLN1 and VCL.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						GTCAGGCAGCGAGCCCGACCG	0.607000													20	49					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99768777	99768777	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr15:99768777G>A	uc002bur.2	-	4	672	c.141C>T	c.(139-141)CTC>CTT	p.L47L	TTC23_uc002bus.2_Silent_p.L47L|TTC23_uc002but.2_Silent_p.L47L|TTC23_uc002buu.2_Silent_p.L47L|TTC23_uc002buv.2_Silent_p.L47L|TTC23_uc002bux.2_Silent_p.L47L|TTC23_uc002buw.2_Silent_p.L47L|TTC23_uc010boq.2_RNA|TTC23_uc002buy.2_Silent_p.L47L|TTC23_uc010bor.2_Silent_p.L47L|TTC23_uc002buz.2_Silent_p.L47L	NM_022905	NP_075056	Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	47	TPR 1.						binding				0	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			TCTCTTCACAGAGGTGGAGTT	0.408000													11	20					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	396885	396885	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:396885C>T	uc002cgp.1	-	2	318	c.141G>A	c.(139-141)GGG>GGA	p.G47G	AXIN1_uc002cgq.1_Silent_p.G47G	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	47					activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CAACACCTTTCCCGGAGCAGA	0.627000											OREG0003698	type=REGULATORY REGION|Gene=AXIN1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	11	51					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	716717	716717	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:716717G>A	uc002cii.1	+	39	4983	c.4929G>A	c.(4927-4929)TGG>TGA	p.W1643*	WDR90_uc002cij.1_Intron|WDR90_uc002cil.1_RNA|WDR90_uc002cin.1_Nonsense_Mutation_p.W258*|WDR90_uc010uul.1_Nonsense_Mutation_p.W194*|WDR90_uc002cio.1_Nonsense_Mutation_p.W242*|WDR90_uc010bqx.1_Nonsense_Mutation_p.W194*|RHOT2_uc010uum.1_5'Flank|RHOT2_uc002cip.2_5'Flank|RHOT2_uc002ciq.2_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1643										ovary(1)	1		Hepatocellular(780;0.0218)				TCTGCCCTTGGGATGGGGCGC	0.642000													13	67					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1261718	1261718	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:1261718C>T	uc002cks.2	+	24	4727	c.4479C>T	c.(4477-4479)GCC>GCT	p.A1493A	CACNA1H_uc002ckt.2_Silent_p.A1493A|CACNA1H_uc002cku.2_Silent_p.A199A|CACNA1H_uc010brj.2_Silent_p.A199A|CACNA1H_uc002ckv.2_Silent_p.A199A	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1493	Extracellular (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCCCTCAGGCCCTGATGTCGC	0.672000													9	74					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1616260	1616260	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:1616260G>A	uc002cmb.2	-	16	2165	c.1803C>T	c.(1801-1803)TTC>TTT	p.F601F	IFT140_uc002clz.2_Silent_p.F252F	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	601										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				CAACATCGTAGAAGCAGATTT	0.488000													32	110					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2367371	2367371	+	Missense_Mutation	SNP	C	T	T	rs148726153		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:2367371C>T	uc002cpy.1	-	10	1736	c.1024G>A	c.(1024-1026)GAC>AAC	p.D342N	ABCA3_uc010bsk.1_Missense_Mutation_p.D342N|ABCA3_uc010bsl.1_Missense_Mutation_p.D342N	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	342					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				AGGGAGGGGTCGCTGCGGGAC	0.622000													28	125					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2367652	2367652	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:2367652G>A	uc002cpy.1	-	9	1699	c.987C>T	c.(985-987)GTC>GTT	p.V329V	ABCA3_uc010bsk.1_Silent_p.V329V|ABCA3_uc010bsl.1_Silent_p.V329V	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	329					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TGCTCACCTTGACACAGAAGA	0.607000													12	73					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3254267	3254267	+	Silent	SNP	G	A	A	rs144582974		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:3254267G>A	uc010uwu.1	+	1	21	c.21G>A	c.(19-21)TCG>TCA	p.S7S		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAAACCAGTCGAGTGTCTCCG	0.557000													4	38					0	0	1	0	0
OR1F1	4992	broad.mit.edu	37	16	3254364	3254364	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:3254364C>T	uc010uwu.1	+	1	118	c.118C>T	c.(118-120)CTG>TTG	p.L40L		NM_012360	NP_036492	O43749	OR1F1_HUMAN	olfactory receptor, family 1, subfamily F,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCCACTGTCCTGGGGAACCT	0.557000													10	97					0	0	1	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266305	3266305	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:3266305G>A	uc010uwv.1	+	1	744	c.596G>A	c.(595-597)GGA>GAA	p.G199E		NR_002169				RecName: Full=Olfactory receptor 1F2; AltName: Full=OLFmf2;												0						TCCACAAAGGGAAGATGGAAA	0.527000													11	69					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4949351	4949351	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:4949351G>A	uc002cyd.1	-	7	731	c.641C>T	c.(640-642)TCG>TTG	p.S214L		NM_002705	NP_002696	O60437	PEPL_HUMAN	periplakin	214	Potential.				keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(4)|central_nervous_system(1)|skin(1)	6						GTCCTGCAGCGAACTCAGGTG	0.647000													6	49					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858184	9858184	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:9858184C>T	uc002czo.3	-	13	3765	c.3217G>A	c.(3217-3219)GAA>AAA	p.E1073K	GRIN2A_uc010uym.1_Missense_Mutation_p.E1073K|GRIN2A_uc010uyn.1_Missense_Mutation_p.E916K|GRIN2A_uc002czr.3_Missense_Mutation_p.E1073K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1073	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.E1073K(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGTCAGGTTCCCTGTGGCAC	0.502000													16	73					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10031959	10031959	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:10031959C>T	uc002czo.3	-	3	1412	c.864G>A	c.(862-864)CTG>CTA	p.L288L	GRIN2A_uc010uym.1_Silent_p.L288L|GRIN2A_uc010uyn.1_Silent_p.L131L|GRIN2A_uc002czr.3_Silent_p.L288L	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	288	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTCTCGCCTCCAGGCTGTAGT	0.562000													5	35					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16138472	16138472	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:16138472C>T	uc010bvi.2	+	8	1150	c.975C>T	c.(973-975)TTC>TTT	p.F325F	ABCC1_uc010bvj.2_Silent_p.F325F|ABCC1_uc010bvk.2_Silent_p.F325F|ABCC1_uc010bvl.2_Silent_p.F325F|ABCC1_uc010bvm.2_Silent_p.F325F|ABCC1_uc002del.3_Silent_p.F209F|ABCC1_uc010bvn.2_Silent_p.F188F	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	325	ABC transmembrane type-1 1.|Helical; Name=6.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGCCCTACTTCCTCATGAGCT	0.512000													13	80					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19451450	19451450	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:19451450G>A	uc002dgc.3	+	3	839	c.90G>A	c.(88-90)TTG>TTA	p.L30L	TMC5_uc010vaq.1_Silent_p.L30L|TMC5_uc002dgb.3_Silent_p.L30L|TMC5_uc010var.1_Silent_p.L30L	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	30	Extracellular (Potential).					integral to membrane				skin(1)	1						AGGGGTATTTGAAAACTCAAG	0.498000													18	67					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476961	20476961	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:20476961C>T	uc010bwe.2	+	4	539	c.300C>T	c.(298-300)GCC>GCT	p.A100A	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Silent_p.A21A|ACSM2A_uc002dhf.3_Silent_p.A100A|ACSM2A_uc002dhg.3_Silent_p.A100A|ACSM2A_uc010vay.1_Silent_p.A21A	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	100					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TCTCGGGAGCCTGTGGCCTGC	0.587000													5	113					0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482880	20482880	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:20482880G>A	uc010bwe.2	+	7	1002	c.763G>A	c.(763-765)GAT>AAT	p.D255N	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.D176N|ACSM2A_uc002dhf.3_Missense_Mutation_p.D255N|ACSM2A_uc002dhg.3_Missense_Mutation_p.D255N|ACSM2A_uc010vay.1_Missense_Mutation_p.D176N	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	255					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GCAAGCCTCTGATATAATGTG	0.458000													32	110					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990798	20990798	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:20990798G>A	uc010vbe.1	-	50	7930	c.7930C>T	c.(7930-7932)CGA>TGA	p.R2644*	DNAH3_uc010vbd.1_Nonsense_Mutation_p.R79*	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2644	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTGTGTCTTCGAAGTTTGTTG	0.478000													15	80					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21014449	21014449	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:21014449C>T	uc010vbe.1	-	42	6103	c.6103G>A	c.(6103-6105)GAA>AAA	p.E2035K		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2035					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGAACTTTTTCCTCCTCTTTG	0.383000													15	91					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21014453	21014453	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:21014453C>T	uc010vbe.1	-	42	6099	c.6099G>A	c.(6097-6099)GAG>GAA	p.E2033E		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2033					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		CTTTTTCCTCCTCTTTGGTGA	0.388000													18	90					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21049142	21049142	+	Missense_Mutation	SNP	G	A	A	rs140821281	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:21049142G>A	uc010vbe.1	-	34	4891	c.4891C>T	c.(4891-4893)CGG>TGG	p.R1631W		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1631					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGCAATGCCCGGAGCAGCAGG	0.522000													9	32					0	0	1	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261887	21261887	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:21261887G>A	uc010bwp.1	+	2	1043	c.1000G>A	c.(1000-1002)GAT>AAT	p.D334N	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	334										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		GTGGGATGACGATGAAGTGGA	0.517000													18	52					0	0	1	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826334	22826334	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:22826334C>T	uc002dli.2	+	1	475	c.403C>T	c.(403-405)CGA>TGA	p.R135*	HS3ST2_uc002dlj.2_RNA	NM_006043	NP_006034	Q9Y278	HS3S2_HUMAN	heparan sulfate D-glucosaminyl	135	Lumenal (Potential).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(48;0.0299)		GGAGTTTATCCGAGTACACCC	0.637000													10	38					0	0	1	0	0
USP31	57478	broad.mit.edu	37	16	23080856	23080856	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:23080856G>A	uc002dll.2	-	16	2570	c.2570C>T	c.(2569-2571)GCC>GTC	p.A857V	USP31_uc002dlk.2_Missense_Mutation_p.A129V|USP31_uc010vca.1_Missense_Mutation_p.A160V|USP31_uc010bxm.2_Missense_Mutation_p.A145V	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	857	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		TTCATTGACGGCCAAGGGGCT	0.488000													10	30					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23721867	23721867	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:23721867G>A	uc002dma.3	-	3	516	c.347C>T	c.(346-348)CCC>CTC	p.P116L	ERN2_uc010bxp.2_Missense_Mutation_p.P116L|ERN2_uc010bxq.1_5'UTR	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	68	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TTCGATGACGGGATCTGCAGG	0.423000													53	211					0	0	1	0	0
AQP8	343	broad.mit.edu	37	16	25235772	25235772	+	Silent	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:25235772G>T	uc002doc.2	+	4	559	c.477G>T	c.(475-477)GTG>GTT	p.V159V		NM_001169	NP_001160	O94778	AQP8_HUMAN	aquaporin 8	159	Helical; (Potential).				cellular response to cAMP	integral to plasma membrane	water channel activity			upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(48;0.044)		GGGCGTTGGTGGCAGAGATCA	0.612000													9	71					2.17888e-05	2.18813e-05	1	1	0
SULT1A2	6799	broad.mit.edu	37	16	28603669	28603669	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:28603669C>T	uc002dqg.1	-	7	1041	c.690G>A	c.(688-690)AAG>AAA	p.K230K	uc010vct.1_Intron|SULT1A2_uc002dqh.1_Silent_p.K230K	NM_177528	NP_803564	P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A,	230					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						TCTTCATCTCCTTGAACGACG	0.557000													34	135					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28883292	28883292	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:28883292G>A	uc002dri.2	+	8	1940	c.1501G>A	c.(1501-1503)GAA>AAA	p.E501K	uc010vct.1_Intron|SH2B1_uc010vdc.1_Missense_Mutation_p.E191K|SH2B1_uc002drj.2_Missense_Mutation_p.E501K|SH2B1_uc002drk.2_Missense_Mutation_p.E501K|SH2B1_uc002drl.2_Missense_Mutation_p.E501K|SH2B1_uc010vdd.1_Missense_Mutation_p.E165K|SH2B1_uc010vde.1_Missense_Mutation_p.E501K|SH2B1_uc002drm.2_Missense_Mutation_p.E501K	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	501	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GGACACTCCGGAAACAGCCAC	0.642000													23	70					0	0	1	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29908156	29908156	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:29908156C>T	uc002duq.3	-	3	738	c.498G>A	c.(496-498)ACG>ACA	p.T166T	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.T96T|SEZ6L2_uc002dur.3_Silent_p.T96T|SEZ6L2_uc002dus.3_Silent_p.T166T|SEZ6L2_uc010vec.1_Silent_p.T166T|SEZ6L2_uc010ved.1_Silent_p.T122T	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	166	Thr-rich.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GGCTGGTCACCGTAGTGGTAA	0.657000													38	127					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29997607	29997607	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:29997607C>T	uc002dva.1	+	16	2797	c.2014C>T	c.(2014-2016)CAG>TAG	p.Q672*	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Nonsense_Mutation_p.Q672*|TAOK2_uc002dvc.1_Nonsense_Mutation_p.Q672*|TAOK2_uc010bzm.1_Nonsense_Mutation_p.Q679*|TAOK2_uc002dvd.1_Nonsense_Mutation_p.Q499*	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	672					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GAAGCAGACCCAGAAGGACTT	0.647000													31	194					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175194	51175194	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:51175194C>T	uc010vgs.1	-	2	970	c.939G>A	c.(937-939)GTG>GTA	p.V313V	SALL1_uc010vgr.1_Silent_p.V216V|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	313					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GTAGCTGTTTCACACCACTAA	0.537000													30	122					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64981857	64981857	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:64981857G>A	uc002eoi.2	-	13	2474	c.2040C>T	c.(2038-2040)ACC>ACT	p.T680T	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Silent_p.T554T	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	680	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GATTCTGGAGGGTGGCAATAT	0.483000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			27	91					0	0	1	0	0
KCTD19	146212	broad.mit.edu	37	16	67327544	67327544	+	Silent	SNP	C	T	T	rs143567769		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:67327544C>T	uc002esu.2	-	12	2172	c.2121G>A	c.(2119-2121)GCG>GCA	p.A707A	KCTD19_uc002est.2_Silent_p.A479A|KCTD19_uc010vjj.1_Silent_p.A450A	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	707						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.A707A(1)		skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCTTGTCTTTCGCTCCAGCTC	0.602000													21	76					0	0	1	0	0
SMPD3	55512	broad.mit.edu	37	16	68395565	68395565	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:68395565C>T	uc002ewa.2	-	8	2229	c.1807G>A	c.(1807-1809)GGC>AGC	p.G603S	SMPD3_uc010cfe.2_Missense_Mutation_p.G586S|SMPD3_uc010vlh.1_Missense_Mutation_p.G595S	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	603	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	ATGCGCCGGCCGTTGCCCTTC	0.657000													19	62					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	71163659	71163659	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:71163659C>T	uc002ezr.2	-	9	1239	c.1111G>A	c.(1111-1113)GAT>AAT	p.D371N	HYDIN_uc010cfz.1_Missense_Mutation_p.D116N|HYDIN_uc002ezv.2_Missense_Mutation_p.D371N|HYDIN_uc010vmc.1_Missense_Mutation_p.D388N|HYDIN_uc010vmd.1_Missense_Mutation_p.D398N|HYDIN_uc002ezw.3_Missense_Mutation_p.D388N	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	371										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGTAAAGGATCAGTAATGCAC	0.443000													4	22					0	0	1	0	0
CHST4	10164	broad.mit.edu	37	16	71570920	71570920	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:71570920G>A	uc002fan.2	+	2	521	c.340G>A	c.(340-342)GAA>AAA	p.E114K	CHST4_uc002fao.2_Missense_Mutation_p.E114K	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	114	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						TGCCTACATGGAACCTGGTCC	0.567000													22	90					0	0	1	0	0
HPR	3250	broad.mit.edu	37	16	72108278	72108278	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:72108278G>A	uc002fby.2	+	3	217	c.187G>A	c.(187-189)GGA>AGA	p.G63R	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	63	Sushi.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				GCGCACAGAAGGAGATGGTAA	0.502000													17	39					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72137629	72137629	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:72137629C>T	uc002fcb.2	+	13	2121	c.1766C>T	c.(1765-1767)GCT>GTT	p.A589V	DHX38_uc010vmp.1_Intron	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	589	Helicase ATP-binding.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				CGGCGTGTAGCTGCCATGTCA	0.572000													11	32					0	0	1	0	0
GAN	8139	broad.mit.edu	37	16	81411177	81411177	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:81411177C>T	uc002fgo.2	+	11	1918	c.1770C>T	c.(1768-1770)TTC>TTT	p.F590F		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	590					cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				AAGGCTTATTCCGTATTCGTG	0.527000													33	129					0	0	1	0	0
RNMTL1	55178	broad.mit.edu	37	17	694832	694832	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:694832G>A	uc002frw.2	+	4	892	c.786G>A	c.(784-786)CGG>CGA	p.R262R		NM_018146	NP_060616	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	262					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		CACATTTCCGGATGCCCATTA	0.512000													15	77					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119138	3119138	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:3119138C>T	uc010vrc.1	+	1	224	c.224C>T	c.(223-225)TCG>TTG	p.S75L		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTCTTCTCATCGGTAACCATC	0.483000													28	162					0	0	1	0	0
SPNS2	124976	broad.mit.edu	37	17	4428422	4428422	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:4428422G>A	uc002fxx.2	+	3	721	c.507G>A	c.(505-507)GTG>GTA	p.V169V		NM_001124758	NP_001118230	Q8IVW8	SPNS2_HUMAN	spinster homolog 2	169	Helical; (Potential).				lipid transport|transmembrane transport	integral to membrane					0						ACAGGAAGGTGATTCTCAGCT	0.617000													41	150					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5073951	5073951	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:5073951G>A	uc002gau.1	+	36	5925	c.3695G>A	c.(3694-3696)GGG>GAG	p.G1232E	USP6_uc002gav.1_Missense_Mutation_p.G1232E|USP6_uc010ckz.1_Missense_Mutation_p.G915E	NM_004505	NP_004496	P35125	UBP6_HUMAN	ubiquitin specific protease 6	1232					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)	5						AAAGAGAATGGGGCTGGGCAG	0.577000			T	COL1A1|CDH11|ZNF9|OMD	aneurysmal bone cysts								6	34					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5456732	5456732	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:5456732G>A	uc002gci.2	-	5	3057	c.2502C>T	c.(2500-2502)CGC>CGT	p.R834R	NLRP1_uc002gcg.1_Silent_p.R834R|NLRP1_uc002gck.2_Silent_p.R834R|NLRP1_uc002gcj.2_Silent_p.R834R|NLRP1_uc002gcl.2_Silent_p.R834R|NLRP1_uc002gch.3_Silent_p.R834R|NLRP1_uc010clh.2_Silent_p.R834R	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	834					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GGCAGCGAGGGCGTCTCAGGG	0.572000													14	43					0	0	1	0	0
SLC13A5	284111	broad.mit.edu	37	17	6594132	6594132	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:6594132G>A	uc002gdj.2	-	10	1491	c.1403C>T	c.(1402-1404)ACC>ATC	p.T468I	SLC13A5_uc010vtf.1_Missense_Mutation_p.T468I|SLC13A5_uc010clq.2_Missense_Mutation_p.T425I|SLC13A5_uc002gdk.2_Missense_Mutation_p.T451I	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	468						integral to membrane	citrate transmembrane transporter activity				0						CAAGGTGGTGGTGGCCACGTT	0.562000													49	197					0	0	1	0	0
CLEC10A	10462	broad.mit.edu	37	17	6980104	6980104	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:6980104C>T	uc002gek.2	-	5	603	c.300G>A	c.(298-300)ACG>ACA	p.T100T	CLEC10A_uc002gej.2_Silent_p.T100T|CLEC10A_uc002gel.2_Silent_p.T100T|CLEC10A_uc010clv.1_Silent_p.T100T	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	100	Extracellular (Potential).|Potential.				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						GAGATGCTATCGTTTCTTCCA	0.607000													65	277					0	0	1	0	0
GPS2	2874	broad.mit.edu	37	17	7217805	7217805	+	Splice_Site	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:7217805A>G	uc002gfv.1	-	2	467	c.204_splice	c.e2+1	p.Q68_splice	GPS2_uc002gfw.1_Splice_Site_p.Q30_splice|GPS2_uc002gfx.1_Splice_Site_p.Q68_splice|NEURL4_uc002gfy.1_Splice_Site|GPS2_uc002gfz.1_Splice_Site_p.Q68_splice	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2						cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				GGGACTGCTTACTTGTTCCTT	0.299000													3	43					0	0	1	0	0
NLGN2	57555	broad.mit.edu	37	17	7318297	7318297	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:7318297C>T	uc002ggt.1	+	5	940	c.867C>T	c.(865-867)GCC>GCT	p.A289A		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor	289	Extracellular (Potential).				cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				AGGCCATCGCCCAGAGTGGCA	0.647000													10	56					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7722319	7722319	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:7722319G>A	uc002giu.1	+	70	10767	c.10753G>A	c.(10753-10755)GAG>AAG	p.E3585K	DNAH2_uc010cnm.1_Missense_Mutation_p.E523K	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3585	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CACAGCCACAGAGGTGACTGA	0.622000													12	25					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7724654	7724654	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:7724654G>A	uc002giu.1	+	72	11123	c.11109G>A	c.(11107-11109)ATG>ATA	p.M3703I	DNAH2_uc010cnm.1_Missense_Mutation_p.M641I	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3703					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AGCTCAACATGGATGAATACA	0.498000													8	41					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7752204	7752204	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:7752204C>T	uc002giw.1	+	11	2974	c.2598C>T	c.(2596-2598)TCC>TCT	p.S866S	KDM6B_uc002gix.2_Silent_p.S168S	NM_001080424	NP_001073893	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	866	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|pancreas(1)	2						CCTCTGCTTCCTCGTCATCTC	0.721000													11	46					0	0	1	0	0
GUCY2D	3000	broad.mit.edu	37	17	7910813	7910813	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:7910813C>T	uc002gjt.2	+	6	1607	c.1533C>T	c.(1531-1533)ACC>ACT	p.T511T		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	511	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				ACGACATCACCTTTCTCCACC	0.572000													24	152					0	0	1	0	0
AURKB	9212	broad.mit.edu	37	17	8108642	8108642	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:8108642A>C	uc002gkm.2	-	8	814	c.753T>G	c.(751-753)AAT>AAG	p.N251K	AURKB_uc010cnu.2_Missense_Mutation_p.N71K|AURKB_uc002gkn.2_Missense_Mutation_p.N252K|AURKB_uc010vuu.1_Missense_Mutation_p.N210K|AURKB_uc002gko.2_RNA	NM_004217	NP_004208	Q96GD4	AURKB_HUMAN	aurora kinase B	251	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(1)|central_nervous_system(1)	4						CCACCTTCTCATTGTGCATGC	0.577000													26	114					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8215940	8215940	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:8215940C>T	uc002glc.2	+	2	704	c.583C>T	c.(583-585)CAG>TAG	p.Q195*	ARHGEF15_uc002glb.1_Nonsense_Mutation_p.Q195*|ARHGEF15_uc002gld.2_Nonsense_Mutation_p.Q195*|ARHGEF15_uc010vuw.1_Nonsense_Mutation_p.Q195*	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	195					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GAGTGGGTCCCAGGAGAACGG	0.617000													7	44					0	0	1	0	0
KRBA2	124751	broad.mit.edu	37	17	8272852	8272852	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:8272852G>A	uc002glf.1	-	2	1085	c.1079C>T	c.(1078-1080)TCC>TTC	p.S360F	KRBA2_uc002glg.1_Missense_Mutation_p.S277F	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	360	Integrase catalytic.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						TCCTTCCAGGGAGCCCTGGCT	0.502000													19	85					0	0	1	0	0
MYH10	4628	broad.mit.edu	37	17	8452049	8452049	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:8452049G>A	uc002gll.2	-	9	1042	c.946C>T	c.(946-948)CCT>TCT	p.P316S	MYH10_uc002glm.2_Missense_Mutation_p.P326S|MYH10_uc010cnx.2_Missense_Mutation_p.P325S|MYH10_uc010cny.1_RNA	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	316	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CCCGGAATAGGAATATAGCCA	0.363000													16	116					0	0	1	0	0
SPDYE4	388333	broad.mit.edu	37	17	8658914	8658914	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:8658914C>T	uc010cnz.1	-	4	586	c.409G>A	c.(409-411)GCT>ACT	p.A137T		NM_001128076	NP_001121548	A6NLX3	SPDE4_HUMAN	speedy homolog E4	137											0						ATGACCATAGCCAGGAGATAC	0.522000													49	211					0	0	1	0	0
USP43	124739	broad.mit.edu	37	17	9590140	9590140	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:9590140G>A	uc010cod.2	+	8	1267	c.1267G>A	c.(1267-1269)GAA>AAA	p.E423K	USP43_uc002gma.3_Missense_Mutation_p.E112K|USP43_uc010vva.1_Missense_Mutation_p.E423K|USP43_uc010coe.2_Missense_Mutation_p.E220K	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	423					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CCTGATAAGGGAAGACAGAGC	0.502000													6	31					0	0	1	0	0
USP43	124739	broad.mit.edu	37	17	9631945	9631945	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:9631945C>T	uc010cod.2	+	15	3010	c.3010C>T	c.(3010-3012)CGG>TGG	p.R1004W	USP43_uc002gma.3_Missense_Mutation_p.R693W|USP43_uc010vva.1_Missense_Mutation_p.R999W|USP43_uc010coe.2_Missense_Mutation_p.R801W|USP43_uc002gmc.3_Missense_Mutation_p.R516W	NM_153210	NP_694942	Q70EL4	UBP43_HUMAN	ubiquitin specific protease 43	1004					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GTCCGTGTTTCGGAAGAAGGA	0.602000													7	40					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10243522	10243522	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:10243522C>T	uc002gmk.1	-	18	2091	c.2001G>A	c.(1999-2001)AGG>AGA	p.R667R		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	667	Myosin head-like.|Actin-binding (By similarity).				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GGTGGGTGCTCCTTAAGTTAG	0.418000													7	33					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10307884	10307884	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:10307884G>A	uc002gmm.2	-	22	2546	c.2451C>T	c.(2449-2451)ATC>ATT	p.I817I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	817					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CATTATACTGGATGCAGAAAA	0.423000									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				9	45					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10359019	10359019	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:10359019G>A	uc002gmn.2	-	19	2197	c.2086C>T	c.(2086-2088)CAG>TAG	p.Q696*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	696	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CACCTCAGCTGATGCAGGACA	0.498000													7	48					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10363552	10363552	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:10363552C>T	uc002gmn.2	-	13	1345	c.1234G>A	c.(1234-1236)GAG>AAG	p.E412K	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	412	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						GTTACGAACTCATTGCCGACC	0.448000													23	102					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10435088	10435088	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:10435088C>T	uc010coi.2	-	22	2687	c.2559G>A	c.(2557-2559)AAG>AAA	p.K853K	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.K853K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	853	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TGGCCATCTCCTTCTCAGTTT	0.433000													17	71					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10535036	10535036	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:10535036G>A	uc002gmq.1	-	35	5255	c.5178C>T	c.(5176-5178)CAC>CAT	p.H1726H		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1726	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TCTTCTTGGTGTGGATGAGGC	0.572000											OREG0024180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	51					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10543080	10543080	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:10543080G>A	uc002gmq.1	-	22	2799	c.2722C>T	c.(2722-2724)CAG>TAG	p.Q908*		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	908	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTGATCAGCTGATCGCATCTT	0.418000													33	81					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11672468	11672468	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:11672468C>T	uc002gne.2	+	38	7442	c.7374C>T	c.(7372-7374)ATC>ATT	p.I2458I	DNAH9_uc010coo.2_Silent_p.I1752I	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2458	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTGAGACCATCCGTGTGTGCT	0.617000													23	128					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11687793	11687793	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:11687793C>T	uc002gne.2	+	41	8066	c.7998C>T	c.(7996-7998)TTC>TTT	p.F2666F	DNAH9_uc010coo.2_Silent_p.F1960F	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	2666	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTACCACCTTCCTACCCACAG	0.522000													34	126					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11774915	11774915	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:11774915G>A	uc002gne.2	+	52	10122	c.10054G>A	c.(10054-10056)GTT>ATT	p.V3352I	DNAH9_uc010coo.2_Missense_Mutation_p.V2646I	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3352					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GAAATGGTAGGTTGGAGGACT	0.512000													26	93					0	0	1	0	0
RICH2	9912	broad.mit.edu	37	17	12860056	12860056	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:12860056C>T	uc002gnr.3	+	15	1662	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	RICH2_uc010vvk.1_Silent_p.F445F|RICH2_uc010vvl.1_Silent_p.F445F|RICH2_uc002gns.3_Silent_p.F245F|RICH2_uc010vvm.1_Silent_p.F445F|RICH2_uc010vvn.1_RNA|RICH2_uc002gnt.1_Silent_p.F168F	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	445	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						ACTGGTTCTTCCCTGGGGGTA	0.522000													7	51					0	0	1	0	0
EVPLL	645027	broad.mit.edu	37	17	18286823	18286823	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:18286823G>A	uc002gte.2	+	9	1053	c.798G>A	c.(796-798)CTG>CTA	p.L266L		NM_001145127	NP_001138599	A8MZ36	EVPLL_HUMAN	envoplakin-like	266											0						AGGAGGCCCTGAAGATGGAGT	0.473000													4	10					0	0	1	0	0
KCNJ12	3768	broad.mit.edu	37	17	21318825	21318825	+	Silent	SNP	C	T	T	rs148773260		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:21318825C>T	uc002gyv.1	+	3	876	c.171C>T	c.(169-171)TTC>TTT	p.F57F		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	57	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	ACATTGAGTTCGCCAACATGG	0.602000										Prostate(3;0.18)			6	86					0	0	1	0	0
PIGS	94005	broad.mit.edu	37	17	26881986	26881986	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:26881986C>T	uc002hbo.2	-	11	1648	c.1275G>A	c.(1273-1275)CGG>CGA	p.R425R	UNC119_uc002hbk.2_5'Flank|UNC119_uc002hbm.2_5'Flank|PIGS_uc002hbn.2_Silent_p.R417R|PIGS_uc010wap.1_Silent_p.R364R	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	425	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					CCCAGAGCAGCCGGTCTAGCT	0.582000													10	52					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28544283	28544283	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:28544283C>T	uc002hey.3	-	6	1282	c.738G>A	c.(736-738)CAG>CAA	p.Q246Q		NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	246	Extracellular (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	CCCCCAGGTCCTGGAGCCCCT	0.587000													23	98					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29557326	29557326	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:29557326G>A	uc002hgg.2	+	23	3372	c.3039G>A	c.(3037-3039)ACG>ACA	p.T1013T	NF1_uc002hgh.2_Silent_p.T1013T|NF1_uc010csn.1_Silent_p.T873T|NF1_uc002hgi.1_Silent_p.T46T	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1013					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAATAAAAACGAAACTGTGTC	0.338000			D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			11	34					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33504139	33504139	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:33504139C>T	uc002hja.2	+	16	2232	c.2135C>T	c.(2134-2136)CCT>CTT	p.P712L	UNC45B_uc002hjb.2_Missense_Mutation_p.P710L|UNC45B_uc002hjc.2_Missense_Mutation_p.P710L|UNC45B_uc010cto.2_Missense_Mutation_p.P631L	NM_173167	NP_775259	Q8IWX7	UN45B_HUMAN	cardiomyopathy associated 4 isoform 1	712					cell differentiation|muscle organ development	cytosol	binding			ovary(3)|central_nervous_system(2)|breast(1)	6		Ovarian(249;0.17)				ATTGCTTTTCCTGGGGAGCGG	0.577000													17	67					0	0	1	0	0
SLFN12	55106	broad.mit.edu	37	17	33747315	33747315	+	Silent	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:33747315T>C	uc002hji.3	-	3	1502	c.1125A>G	c.(1123-1125)CAA>CAG	p.Q375Q	SLFN12_uc002hjj.3_Silent_p.Q375Q|SLFN12_uc010cts.2_Silent_p.Q375Q	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	375							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTCTCTGCCGTTGCCATTCCA	0.403000													12	53					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072975	34072975	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:34072975G>T	uc002hjv.1	-	6	1569	c.1541C>A	c.(1540-1542)ACA>AAA	p.T514K		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	514					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCTTCCTGGTGTTGGGGGGCG	0.612000													13	63					1.49906e-05	1.50634e-05	1	1	0
MMP28	79148	broad.mit.edu	37	17	34094838	34094838	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:34094838G>A	uc002hjy.1	-	9	1360	c.1101C>T	c.(1099-1101)GTC>GTT	p.V367V	MMP28_uc002hjw.1_RNA|MMP28_uc002hjz.1_RNA	NM_024302	NP_077278	Q9H239	MMP28_HUMAN	matrix metalloproteinase 28 isoform 1	367	Hemopexin-like 1.				proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		GGGGCAGCCCGACCCATCTTT	0.488000													6	26					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38133112	38133112	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:38133112G>A	uc002htl.1	+	12	1257	c.1139G>A	c.(1138-1140)GGT>GAT	p.G380D	GSDMA_uc002htm.1_Missense_Mutation_p.G380D	NM_178171	NP_835465	Q96QA5	GSDMA_HUMAN	gasdermin 1	380					apoptosis|induction of apoptosis	perinuclear region of cytoplasm					0						GATAAAGAGGGTGTTTTCCCC	0.547000													26	123					0	0	1	0	0
KRT25	147183	broad.mit.edu	37	17	38910144	38910144	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:38910144C>T	uc002hve.2	-	3	698	c.637G>A	c.(637-639)GAG>AAG	p.E213K		NM_181534	NP_853512	Q7Z3Z0	K1C25_HUMAN	keratin 25	213	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity			ovary(2)	2		Breast(137;0.00526)				TAAGTCATCTCCTCACTCAGG	0.448000													27	126					0	0	1	0	0
KRT10	3858	broad.mit.edu	37	17	38977341	38977341	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:38977341T>C	uc002hvi.2	-	2	682	c.656A>G	c.(655-657)AAC>AGC	p.N219S	KRT10_uc010cxd.2_5'Flank|TMEM99_uc002hvj.1_Intron	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	219	Coil 1B.|Rod.|Gly-rich.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				AAGCAGGATGTTGGCATTATC	0.428000													14	67					0	0	1	0	0
KRT23	25984	broad.mit.edu	37	17	39084802	39084802	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:39084802C>T	uc002hvm.1	-	5	1283	c.694G>A	c.(694-696)GGT>AGT	p.G232S	KRT23_uc010wfl.1_Missense_Mutation_p.G95S|KRT23_uc010cxf.1_Missense_Mutation_p.G19S|KRT23_uc010cxg.2_Missense_Mutation_p.G232S|KRT23_uc002hvn.1_Missense_Mutation_p.G232S	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	232	Rod.|Linker 12.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				TCCCTGGGACCTGTATCCACC	0.398000													33	138					0	0	1	0	0
Unknown	0	broad.mit.edu	37	17	39296158	39296158	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:39296158G>A	uc010cxk.1	-	1		c.546C>T								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		AGGGACGGGGGCAGGTGGAAA	0.498000													4	18					0	0	1	0	0
KRT38	8687	broad.mit.edu	37	17	39595490	39595490	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:39595490C>T	uc002hwq.1	-	3	1120	c.697G>A	c.(697-699)GAG>AAG	p.E233K		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	233	Rod.|Coil 1B.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				AGCTGCTCCTCCTTCAGGGAC	0.667000													12	43					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	41001332	41001332	+	Silent	SNP	C	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:41001332C>A	uc002ibu.2	+	2	1853	c.1818C>A	c.(1816-1818)CCC>CCA	p.P606P	AOC2_uc002ibt.2_Intron|AOC3_uc002ibv.2_5'Flank	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	606					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		TCCACAGCCCCCTTGGCATAC	0.627000													53	236					4.60343e-24	4.65686e-24	1	1	0
BRCA1	672	broad.mit.edu	37	17	41246734	41246734	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:41246734C>T	uc002icq.2	-	10	1046	c.814G>A	c.(814-816)GAG>AAG	p.E272K	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.E201K|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.E225K|BRCA1_uc002ict.2_Missense_Mutation_p.E272K|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.E272K|BRCA1_uc002ide.1_Missense_Mutation_p.E103K|BRCA1_uc010cyy.1_Missense_Mutation_p.E272K|BRCA1_uc010whs.1_Missense_Mutation_p.E272K|BRCA1_uc010cyz.2_Missense_Mutation_p.E225K|BRCA1_uc010cza.2_Missense_Mutation_p.E246K|BRCA1_uc010wht.1_5'UTR	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	272					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCACATGGCTCCACATGCAAG	0.418000			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			12	62					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46627846	46627846	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:46627846C>T	uc002inn.2	-	2	1546	c.1146G>A	c.(1144-1146)GGG>GGA	p.G382G	HOXB3_uc010wlm.1_Silent_p.G309G|HOXB3_uc010dbf.2_Silent_p.G382G|HOXB3_uc010dbg.2_Silent_p.G382G|HOXB3_uc002ino.2_Silent_p.G382G|HOXB3_uc010wlk.1_Silent_p.G250G|HOXB3_uc010wll.1_Silent_p.G309G	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	382					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGTCCAGGTTCCCGGAAGGGT	0.701000											OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	65					0	0	1	0	0
PHB	5245	broad.mit.edu	37	17	47489156	47489156	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:47489156A>C	uc002iox.1	-	3	207	c.134T>G	c.(133-135)GTG>GGG	p.V45G		NM_002634	NP_002625	P35232	PHB_HUMAN	prohibitin	45					cellular response to interleukin-6|DNA replication|glucocorticoid receptor signaling pathway|histone deacetylation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|progesterone receptor signaling pathway|regulation of apoptosis	integral to plasma membrane|mitochondrial inner membrane|nucleoplasm	histone deacetylase binding|transcription regulatory region DNA binding				0	all_cancers(4;2.62e-14)|Breast(4;4.21e-29)|all_epithelial(4;6.9e-18)		Epithelial(5;8.1e-06)|all cancers(6;7.71e-05)			AATGTCCTGCACTCCACGGAA	0.463000													5	35					0	0	1	0	0
SGCA	6442	broad.mit.edu	37	17	48244987	48244987	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:48244987G>A	uc002iqi.2	+	3	238	c.202G>A	c.(202-204)GGA>AGA	p.G68R	SGCA_uc010wmh.1_Intron|SGCA_uc002iqj.2_Missense_Mutation_p.G68R|SGCA_uc010wmi.1_RNA	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	68	Extracellular (Potential).		G -> E (in LGMD2D).		muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						CCACCTCCAGGGACACCCAGA	0.672000													22	91					0	0	1	0	0
MYCBPAP	84073	broad.mit.edu	37	17	48602351	48602351	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:48602351C>T	uc010wmr.1	+	13	2040	c.1878C>T	c.(1876-1878)ACC>ACT	p.T626T	MYCBPAP_uc002iqz.2_RNA	NM_032133	NP_115509	Q8TBZ2	MYBPP_HUMAN	Myc-binding protein-associated protein	589					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			urinary_tract(2)|skin(2)|ovary(1)|pancreas(1)	6	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CCTATCTCACCGAGGAAGACT	0.627000													19	145					0	0	1	0	0
SPATA20	64847	broad.mit.edu	37	17	48625796	48625796	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:48625796C>T	uc002irf.2	+	2	371	c.230C>T	c.(229-231)GCC>GTC	p.A77V	SPATA20_uc002irc.2_5'UTR|SPATA20_uc002ire.2_Missense_Mutation_p.A33V|SPATA20_uc002ird.2_Missense_Mutation_p.A93V|SPATA20_uc010wmv.1_Missense_Mutation_p.A77V|SPATA20_uc002irg.2_RNA	NM_022827	NP_073738	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	77					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding				0	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			CTACAACATGCCTACAATCCT	0.617000													5	47					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917212	48917212	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:48917212C>T	uc002isv.3	+	2	1257	c.563C>T	c.(562-564)CCA>CTA	p.P188L	WFIKKN2_uc010dbu.2_Missense_Mutation_p.P95L	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	188						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			AGCCCCCCACCACCTGAGACC	0.637000													19	56					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54526461	54526461	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:54526461G>A	uc002iun.1	+	10	1165	c.1130G>A	c.(1129-1131)AGA>AAA	p.R377K		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	377										large_intestine(1)|ovary(1)	2						TATGACGACAGAGAGCCCAGA	0.478000													16	50					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57058075	57058075	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:57058075G>A	uc002iwx.2	+	7	2078	c.1951G>A	c.(1951-1953)GGG>AGG	p.G651R	PPM1E_uc010ddd.2_Missense_Mutation_p.G414R	NM_014906	NP_055721	Q8WY54	PPM1E_HUMAN	protein phosphatase 1E	660					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(3)|lung(1)|skin(1)	5	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			TGTCTGTTCAGGGTTGGAAAA	0.458000													39	202					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61623250	61623250	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:61623250G>A	uc002jay.2	+	14	3052	c.2972G>A	c.(2971-2973)AGT>AAT	p.S991N	KCNH6_uc010wpl.1_Missense_Mutation_p.S832N|KCNH6_uc010wpm.1_Missense_Mutation_p.S955N|KCNH6_uc002jaz.1_Missense_Mutation_p.S902N	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	991	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	TTTGCAGGGAGTTGGGGCCAC	0.498000													11	54					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61949951	61949951	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:61949951G>A	uc002jch.2	-	4	557	c.442C>T	c.(442-444)CAA>TAA	p.Q148*	CSH2_uc002jcg.2_Intron|CSH2_uc002jci.2_Nonsense_Mutation_p.Q148*|GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Nonsense_Mutation_p.Q148*	NM_020991	NP_066271	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2 isoform 1	148					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding				0						ATCAGCGTTTGGATGCCTTCC	0.587000													16	86					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62130146	62130146	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:62130146C>T	uc002jdz.2	-	17	2360	c.2247G>A	c.(2245-2247)GAG>GAA	p.E749E		NM_001433	NP_001424	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signalling 1	749	Cytoplasmic (Potential).|Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|lung(2)|stomach(1)|ovary(1)|kidney(1)	9						TCACAGGGTTCTCCTTACAGT	0.527000													6	36					0	0	1	0	0
DDX5	1655	broad.mit.edu	37	17	62499389	62499389	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:62499389T>C	uc002jek.2	-	7	974	c.727A>G	c.(727-729)ACC>GCC	p.T243A	DDX5_uc010deh.2_Missense_Mutation_p.T243A|DDX5_uc002jej.2_Missense_Mutation_p.T138A|DDX5_uc010wqa.1_Missense_Mutation_p.T164A|DDX5_uc002jel.1_5'UTR	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	243	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			ACAAGGTAGGTTGTTCTTCTC	0.368000			T	ETV4	prostate								23	96					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62750150	62750150	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:62750150G>A	uc010wqc.1	-	10		c.2208C>T				NR_026899				Homo sapiens cDNA FLJ30780 fis, clone FEBRA2000856.												0						TGGCATCCAGGATAACCAGAA	0.378000													70	284					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64222231	64222231	+	Missense_Mutation	SNP	G	A	A	rs55645281		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:64222231G>A	uc002jfn.3	-	3	312	c.253C>T	c.(253-255)CCT>TCT	p.P85S		NM_000042	NP_000033	P02749	APOH_HUMAN	apolipoprotein H precursor	85	Sushi 2.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding				0			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			CCAGCAAAAGGACATACTCTG	0.318000													12	52					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64876678	64876678	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:64876678G>A	uc010wqi.1	+	4	525	c.288G>A	c.(286-288)ATG>ATA	p.M96I	CACNG5_uc002jfr.2_Missense_Mutation_p.M96I|CACNG5_uc010wqj.1_Missense_Mutation_p.M96I	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	96					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			AATTAGAGATGATCCGCTCAG	0.522000													14	58					0	0	1	0	0
CACNG1	786	broad.mit.edu	37	17	65040921	65040921	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:65040921G>A	uc002jfu.2	+	1	216	c.145G>A	c.(145-147)GCC>ACC	p.A49T		NM_000727	NP_000718	Q06432	CCG1_HUMAN	voltage-dependent calcium channel gamma-1	49					muscle contraction	voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(12;1.04e-10)|Breast(2;1.45e-16)|all_epithelial(3;4.81e-12)				Amlodipine(DB00381)|Diltiazem(DB00343)|Ibutilide(DB00308)|Lercanidipine(DB00528)|Magnesium Sulfate(DB00653)|Nimodipine(DB00393)|Nitrendipine(DB01054)|Verapamil(DB00661)	CTGCGAGGCGGCCCACTTCGG	0.647000													12	84					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65185812	65185812	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:65185812G>A	uc010wqk.1	-	11	944	c.757C>T	c.(757-759)CTT>TTT	p.L253F	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.L253F	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CATTCACTAAGCTGAAAACAG	0.378000													13	59					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67178857	67178857	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:67178857G>A	uc010dfa.1	-	22	3469	c.2590C>T	c.(2590-2592)CCC>TCC	p.P864S	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.P465S	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	864					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TTGTAGGAGGGATCATCTGAG	0.353000													30	83					0	0	1	0	0
CD300C	10871	broad.mit.edu	37	17	72539102	72539102	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:72539102G>A	uc002jky.1	-	3	786	c.425C>T	c.(424-426)CCC>CTC	p.P142L		NM_006678	NP_006669	Q08708	CLM6_HUMAN	CD300C antigen precursor	142	Pro-rich.|Extracellular (Potential).				cellular defense response	integral to plasma membrane	transmembrane receptor activity				0						GGAGCTCTGGGGGCTGGAGGC	0.612000													12	98					0	0	1	0	0
CD300C	10871	broad.mit.edu	37	17	72541035	72541035	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:72541035G>A	uc002jky.1	-	2	474	c.113C>T	c.(112-114)TCC>TTC	p.S38F		NM_006678	NP_006669	Q08708	CLM6_HUMAN	CD300C antigen precursor	38	Extracellular (Potential).|Ig-like V-type.				cellular defense response	integral to plasma membrane	transmembrane receptor activity				0						CACACTCAGGGATCCCCCCAC	0.547000													15	76					0	0	1	0	0
CD300LD	100131439	broad.mit.edu	37	17	72584938	72584939	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:72584938_72584939CC>TT	uc002jkz.2	-	2	119_120	c.90_91GG>AA	c.(88-93)TCGGAG>TCAAAG	p.E31K	C17orf77_uc002jla.1_Intron	NM_001115152	NP_001108624	Q6UXZ3	CLM4_HUMAN	CD300 molecule-like family member d precursor	31	Extracellular (Potential).|Ig-like V-type.					integral to membrane|plasma membrane	receptor activity				0						GAGCCCTGCTCCGAGCCATTCA	0.525000													18	112					0	0	1	0	0
C17orf77	146723	broad.mit.edu	37	17	72588657	72588657	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:72588657G>A	uc002jla.1	+	3	834	c.472G>A	c.(472-474)GGA>AGA	p.G158R	CD300LD_uc002jkz.2_5'Flank	NM_152460	NP_689673	Q96MU5	CQ077_HUMAN	hypothetical protein LOC146723	158						extracellular region					0						GGAGGAGCCAGGAGGAACCCA	0.577000													9	43					0	0	1	0	0
C17orf28	283987	broad.mit.edu	37	17	72954806	72954806	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:72954806G>A	uc002jmj.3	-	10	1351	c.1202C>T	c.(1201-1203)CCC>CTC	p.P401L	C17orf28_uc010wrs.1_Missense_Mutation_p.P200L	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	401	Helical; (Potential).					integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					GAAGAGGATGGGGACAAGGAT	0.622000											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	63					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73949623	73949623	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:73949623G>A	uc002jqf.2	-	7	1143	c.853C>T	c.(853-855)CTT>TTT	p.L285F	ACOX1_uc010wsq.1_Missense_Mutation_p.L247F|ACOX1_uc002jqe.2_Missense_Mutation_p.L285F|ACOX1_uc010wsr.1_Missense_Mutation_p.L217F	NM_007292	NP_009223	Q15067	ACOX1_HUMAN	acyl-Coenzyme A oxidase 1 isoform b	285					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			ovary(1)	1						TCTCCCACAAGGAAGGACCTG	0.532000													16	57					0	0	1	0	0
CDK3	1018	broad.mit.edu	37	17	73998612	73998612	+	Silent	SNP	C	G	G	rs61747000	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:73998612C>G	uc010dgt.2	+	6	583	c.507C>G	c.(505-507)CGC>CGG	p.R169R	CDK3_uc002jqg.3_Silent_p.R197R	NM_001258	NP_001249	Q00526	CDK3_HUMAN	cyclin-dependent kinase 3	169	Protein kinase.				cell division|cell proliferation|mitosis		ATP binding|cyclin-dependent protein kinase activity			central_nervous_system(1)	1						TGTGGTATCGCGCCCCCGAGA	0.542000													13	58					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74944083	74944083	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:74944083G>A	uc002jti.2	+	15	2225	c.2122G>A	c.(2122-2124)GCC>ACC	p.A708T	MGAT5B_uc002jth.2_Missense_Mutation_p.A697T|MGAT5B_uc002jtj.2_Missense_Mutation_p.A104T	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	699	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GCCTGGGAGGGCCTGCACCGA	0.682000													6	27					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78321567	78321567	+	Silent	SNP	C	T	T	rs150377982		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:78321567C>T	uc002jyh.1	+	4	3874	c.3651C>T	c.(3649-3651)CCC>CCT	p.P1217P		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GGGTTCACCCCAACTTCCGCC	0.547000													14	58					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79418857	79418857	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:79418857C>T	uc002kaf.2	+	10	4140	c.4140C>T	c.(4138-4140)ATC>ATT	p.I1380I	BAHCC1_uc002kae.2_Silent_p.I610I|hsa-mir-3186|MI0014229_5'Flank	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	1380							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			GCATGCAGATCCTGCAGCGCA	0.711000													5	14					0	0	1	0	0
FOXK2	3607	broad.mit.edu	37	17	80559180	80559181	+	Missense_Mutation	DNP	CG	TT	TT	rs61737961		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:80559180_80559181CG>TT	uc002kfn.2	+	9	1959_1960	c.1788_1789CG>TT	c.(1786-1791)GCCGCG>GCTTCG	p.A597S	FOXK2_uc010diu.2_Missense_Mutation_p.P304L|FOXK2_uc002kfo.2_RNA|FOXK2_uc002kfp.2_RNA	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	597					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			TCATTTCAGCCGCGGCGAGTCC	0.629000													14	63					0	0	1	0	0
B3GNTL1	146712	broad.mit.edu	37	17	81006361	81006361	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:81006361G>A	uc002kgg.1	-	3	277	c.263C>T	c.(262-264)CCC>CTC	p.P88L	B3GNTL1_uc002kgf.1_5'UTR	NM_001009905	NP_001009905	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal	88							transferase activity, transferring glycosyl groups			ovary(1)|pancreas(1)	2	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TCTAGGAGAGGGAGAATCGTG	0.418000													8	81					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886878	9886878	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:9886878C>T	uc002koi.3	+	2	851	c.402C>T	c.(400-402)CTC>CTT	p.L134L	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Silent_p.L67L	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	134	2.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						AGGAGGACCTCCCCAAGTCCT	0.542000													21	127					0	0	1	0	0
HRH4	59340	broad.mit.edu	37	18	22057305	22057305	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:22057305C>T	uc002kvi.2	+	3	1052	c.952C>T	c.(952-954)CCA>TCA	p.P318S	HRH4_uc010xbd.1_3'UTR|HRH4_uc010dlx.2_Missense_Mutation_p.P230S	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	318	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TTGCTGGGCTCCATATTCTCT	0.423000													41	169					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28581686	28581686	+	Silent	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28581686T>C	uc002kwj.3	-	14	2288	c.2133A>G	c.(2131-2133)GTA>GTG	p.V711V	DSC3_uc002kwi.3_Silent_p.V711V	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	711	Helical; (Potential).				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			AAACTCCACATACTAAAGTTA	0.299000													11	44					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28598661	28598661	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28598661C>T	uc002kwj.3	-	8	1203	c.1048G>A	c.(1048-1050)GAT>AAT	p.D350N	DSC3_uc002kwi.3_Missense_Mutation_p.D350N	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	350	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GGTGCATTATCATTTGAATCT	0.308000													4	55					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28598670	28598670	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28598670C>T	uc002kwj.3	-	8	1194	c.1039G>A	c.(1039-1041)GAT>AAT	p.D347N	DSC3_uc002kwi.3_Missense_Mutation_p.D347N	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	347	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TCATTTGAATCTGTTACTGTT	0.333000													5	55					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28710546	28710546	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28710546C>T	uc002kwn.2	-	16	2878	c.2616G>A	c.(2614-2616)GAG>GAA	p.E872E	DSC1_uc002kwm.2_3'UTR|uc002kwo.1_5'Flank	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	872	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ACTCCAGTCCCTCTTCTTCCT	0.423000													18	89					0	0	1	0	0
DSC1	1823	broad.mit.edu	37	18	28720199	28720199	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28720199G>A	uc002kwn.2	-	10	1588	c.1326C>T	c.(1324-1326)TTC>TTT	p.F442F	DSC1_uc002kwm.2_Silent_p.F442F	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	442	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			CTGCTTTAGAGAATTGTGCCT	0.398000													17	80					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28918418	28918418	+	Splice_Site	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28918418G>A	uc002kwp.2	+	10	1617	c.1405_splice	c.e10+1	p.D469_splice		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein						calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TCTATAGATGGTAAGAAATTA	0.308000													8	50					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28926106	28926106	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28926106G>A	uc002kwp.2	+	14	2257	c.2045G>A	c.(2044-2046)AGG>AAG	p.R682K	DSG1_uc010xbp.1_Missense_Mutation_p.R41K	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	682	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AATTCTATGAGGGAATGTAGA	0.423000													11	69					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28965102	28965102	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28965102G>A	uc002kwq.2	+	2	187	c.52G>A	c.(52-54)GTG>ATG	p.V18M	DSG4_uc002kwr.2_Missense_Mutation_p.V18M	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	18					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AAAACAGGTGGTGATGGAAGT	0.199000													19	72					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28979385	28979385	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:28979385C>T	uc002kwq.2	+	9	1291	c.1156C>T	c.(1156-1158)CAT>TAT	p.H386Y	DSG4_uc002kwr.2_Missense_Mutation_p.H386Y	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	386	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACCTGCATTTCATCCAAGTAC	0.418000													20	64					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093406	30093406	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:30093406C>T	uc010dmc.2	+	1		c.1781C>T				NR_003558				Homo sapiens cDNA clone IMAGE:5265376, partial cds.												0						CCCACCAGCTCCCTTGCTGAA	0.517000													9	50					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31322974	31322974	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:31322974C>T	uc010dmg.1	+	12	3217	c.3162C>T	c.(3160-3162)CTC>CTT	p.L1054L	ASXL3_uc002kxq.2_Silent_p.L761L	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1054	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CCAGGACCCTCGCAGATATCA	0.592000													4	31					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325478	31325478	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:31325478T>C	uc010dmg.1	+	12	5721	c.5666T>C	c.(5665-5667)GTT>GCT	p.V1889A	ASXL3_uc002kxq.2_Missense_Mutation_p.V1596A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1889					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AACAGAATTGTTCACAGCCCT	0.512000													55	215					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561226	44561226	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:44561226G>A	uc002lcr.1	-	1	763	c.410C>T	c.(409-411)CCG>CTG	p.P137L	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	137					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CTGTTGCCCCGGAGGTGTTCT	0.642000													30	123					0	0	1	0	0
KIAA0427	9811	broad.mit.edu	37	18	46237999	46237999	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:46237999C>T	uc002ldc.2	+	7	802	c.517C>T	c.(517-519)CCG>TCG	p.P173S	KIAA0427_uc002ldd.2_Missense_Mutation_p.P173S	NM_014772	NP_055587	O43310	CTIF_HUMAN	hypothetical protein LOC9811 isoform 1	173	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding				0						GGGCTACCACCCGATGCCCCA	0.522000											OREG0024973	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	296					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47432958	47432958	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:47432958G>A	uc002leb.2	-	19	2533	c.2245C>T	c.(2245-2247)CGA>TGA	p.R749*		NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	749	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		TGGCCTGCTCGAAAGAAGATC	0.557000													23	68					0	0	1	0	0
CXXC1	30827	broad.mit.edu	37	18	47812290	47812290	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:47812290C>G	uc002leq.3	-	5	1201	c.468G>C	c.(466-468)CAG>CAC	p.Q156H	CXXC1_uc002lep.3_Missense_Mutation_p.Q13H|CXXC1_uc002ler.3_Missense_Mutation_p.Q156H|CXXC1_uc010doy.2_Missense_Mutation_p.Q156H|CXXC1_uc002les.2_Missense_Mutation_p.Q156H	NM_014593	NP_055408	Q9P0U4	CXXC1_HUMAN	CXXC finger 1 (PHD domain) isoform 2	156					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						gctgctgctgctggtgatgct	0.468000													3	43					0	0	1	0	0
MAPK4	5596	broad.mit.edu	37	18	48248376	48248376	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:48248376G>A	uc002lev.2	+	4	1760	c.760G>A	c.(760-762)GAC>AAC	p.D254N	MAPK4_uc010xdm.1_Missense_Mutation_p.D43N|MAPK4_uc010doz.2_Intron	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	254	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		GGAAGACAAGGACGAGCTGCT	0.577000													14	45					0	0	1	0	0
CCBE1	147372	broad.mit.edu	37	18	57103370	57103370	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:57103370G>A	uc002lib.2	-	11	1061	c.991C>T	c.(991-993)CCC>TCC	p.P331S	CCBE1_uc010dpq.2_Missense_Mutation_p.P60S|CCBE1_uc002lia.2_Missense_Mutation_p.P184S	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	331	Collagen-like 2.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				GAACCAGGGGGTCCCTGTGTA	0.532000													17	66					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59157987	59157987	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:59157987C>T	uc010dps.1	+	1	213	c.201C>T	c.(199-201)TTC>TTT	p.F67F	CDH20_uc002lif.2_Silent_p.F61F	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	67	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				ACCAGTTTTTCGTTCTGGAAG	0.478000													30	109					0	0	1	0	0
RNF152	220441	broad.mit.edu	37	18	59483147	59483147	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:59483147C>T	uc002lih.1	-	2	962	c.550G>A	c.(550-552)GGC>AGC	p.G184S		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	184	Helical; (Potential).				apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				AGCACGATGCCGAGGAGGAAG	0.567000													24	123					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305285	61305285	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:61305285C>T	uc002ljf.2	-	8	927	c.841G>A	c.(841-843)GAT>AAT	p.D281N	SERPINB4_uc002lje.2_Missense_Mutation_p.D260N|SERPINB4_uc002ljg.2_Missense_Mutation_p.D281N	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	281					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						AAGTGTAAATCGACACATGTC	0.403000													7	40					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61460488	61460488	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:61460488G>A	uc002ljl.2	+	4	409	c.313G>A	c.(313-315)GAA>AAA	p.E105K	SERPINB7_uc002ljm.2_Missense_Mutation_p.E105K|SERPINB7_uc010xet.1_Missense_Mutation_p.E88K|SERPINB7_uc010dqg.2_Missense_Mutation_p.E105K	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	105					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				GCTTTTTGCTGAAAAAGTGTA	0.373000													11	43					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66504344	66504344	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:66504344G>A	uc002lkk.2	+	4	567	c.344G>A	c.(343-345)AGT>AAT	p.S115N	CCDC102B_uc002lki.2_Missense_Mutation_p.S115N|CCDC102B_uc002lkj.1_Missense_Mutation_p.S115N	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	115	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GAAAGGAACAGTGCCAGGGAG	0.473000													10	59					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754495	76754495	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:76754495C>T	uc002lmt.2	+	2	2504	c.2504C>T	c.(2503-2505)TCG>TTG	p.S835L	SALL3_uc010dra.2_Missense_Mutation_p.S442L	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	835					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TCCCCGCCCTCGGTCATCTCC	0.657000													12	60					0	0	1	0	0
ADNP2	22850	broad.mit.edu	37	18	77895182	77895182	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr18:77895182G>A	uc002lnw.2	+	4	2341	c.1886G>A	c.(1885-1887)GGA>GAA	p.G629E		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	629					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GTTCCCCCTGGAGGCCTTGCG	0.622000													24	89					0	0	1	0	0
SHC2	25759	broad.mit.edu	37	19	434845	434845	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:434845G>A	uc002loq.3	-	8	974	c.974C>T	c.(973-975)TCG>TTG	p.S325L	SHC2_uc002lop.3_Missense_Mutation_p.S66L	NM_012435	NP_036567	P98077	SHC2_HUMAN	SHC (Src homology 2 domain containing)	325	PID.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol					0		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCCAGGCCGACTCCTCCGG	0.647000													21	71					0	0	1	0	0
CDC34	997	broad.mit.edu	37	19	535890	535890	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:535890C>T	uc002lov.2	+	2	430	c.231C>T	c.(229-231)TTC>TTT	p.F77F		NM_004359	NP_004350	P49427	UB2R1_HUMAN	ubiquitin-conjugating enzyme Cdc34	77					DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|negative regulation of cAMP-mediated signaling|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination	cytoplasm|nucleus	ATP binding|protein binding|ubiquitin-protein ligase activity				0		all_cancers(10;1.94e-35)|all_epithelial(18;5.94e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTTTCGGTTCCTGACCAAGA	0.642000													83	463					0	0	1	0	0
MED16	10025	broad.mit.edu	37	19	875447	875447	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:875447G>A	uc002lqd.1	-	10	1719	c.1568C>T	c.(1567-1569)TCC>TTC	p.S523F	MED16_uc010drw.1_Missense_Mutation_p.S348F|MED16_uc002lqe.2_Missense_Mutation_p.S512F|MED16_uc002lqf.2_Missense_Mutation_p.S512F|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Missense_Mutation_p.S443F|MED16_uc010xfx.1_Missense_Mutation_p.S368F|MED16_uc010xfy.1_Intron|MED16_uc010xfz.1_5'Flank	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	523					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GATCCGGGTGGAGAGGACCTG	0.652000													3	14					0	0	1	0	0
SBNO2	22904	broad.mit.edu	37	19	1123971	1123971	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:1123971G>A	uc002lrk.3	-	6	730	c.492C>T	c.(490-492)TCC>TCT	p.S164S	SBNO2_uc002lrj.3_Silent_p.S107S|SBNO2_uc010dse.2_Silent_p.S157S|SBNO2_uc010xgj.1_Silent_p.S107S|SBNO2_uc010dsf.2_Silent_p.S107S	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	164					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTGCTGTGGGAGGGCAGAA	0.652000													18	29					0	0	1	0	0
PLEKHJ1	55111	broad.mit.edu	37	19	2234021	2234021	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:2234021G>T	uc002lvf.1	-	5	441	c.360C>A	c.(358-360)AAC>AAA	p.N120K	SF3A2_uc002lvg.2_5'Flank	NM_018049	NP_060519	Q9NW61	PKHJ1_HUMAN	pleckstrin homology domain containing, family J	120							protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGGATTTCGTTCCTGTAGA	0.637000													49	257					6.4308e-24	6.50147e-24	1	1	0
LMNB2	84823	broad.mit.edu	37	19	2431606	2431606	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:2431606C>T	uc002lvy.2	-	11	1788	c.1701G>A	c.(1699-1701)GAG>GAA	p.E567E	LMNB2_uc010dtc.1_5'Flank|LMNB2_uc002lwa.1_Silent_p.E587E	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	567	Tail.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCCCATTCTCATTCTCAC	0.622000													39	225					0	0	1	0	0
DIRAS1	148252	broad.mit.edu	37	19	2717260	2717260	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:2717260G>A	uc002lwf.3	-	2	703	c.545C>T	c.(544-546)TCC>TTC	p.S182F		NM_145173	NP_660156	O95057	DIRA1_HUMAN	DIRAS family, GTP-binding RAS-like 1	182					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTTCCCGGAGCGCTTGCC	0.647000													33	184					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3907802	3907802	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:3907802G>A	uc002lyy.3	+	5	859	c.429G>A	c.(427-429)ACG>ACA	p.T143T	ATCAY_uc010xhz.1_Silent_p.T149T|ATCAY_uc010dts.2_5'Flank	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	143					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		ACGGCACGACGGAGGACGGCA	0.637000													16	84					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6772975	6772975	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:6772975C>T	uc002mfu.1	+	1	254	c.157C>T	c.(157-159)CAT>TAT	p.H53Y	VAV1_uc010xjh.1_Missense_Mutation_p.H53Y|VAV1_uc010dva.1_Missense_Mutation_p.H53Y	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	53	Leu-rich.|CH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						CCTGCTACCCCATGCCATCAA	0.657000													36	200					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6921782	6921782	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:6921782G>A	uc002mfw.2	+	14	1717	c.1679G>A	c.(1678-1680)GGA>GAA	p.G560E	EMR1_uc010dvc.2_Missense_Mutation_p.G560E|EMR1_uc010dvb.2_Missense_Mutation_p.G508E|EMR1_uc010xji.1_Missense_Mutation_p.G419E|EMR1_uc010xjj.1_Missense_Mutation_p.G383E	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	560	GPS.|Extracellular (Potential).|Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					GTGAAGGGTGGAAGATGGACA	0.423000													14	49					0	0	1	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7534917	7534917	+	Splice_Site	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:7534917T>C	uc002mgi.2	+	18	3602	c.3349_splice	c.e18+2	p.D1117_splice	ARHGEF18_uc010xjm.1_Splice_Site_p.D959_splice|ARHGEF18_uc002mgh.2_Splice_Site_p.D959_splice|ARHGEF18_uc002mgj.1_Splice_Site_p.D754_splice	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18						actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				CCCCACCAGGTGAGCCCCCAC	0.662000													30	99					0	0	1	0	0
KIAA1543	57662	broad.mit.edu	37	19	7671229	7671229	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:7671229C>T	uc002mgv.3	+	3	576	c.475C>T	c.(475-477)CCC>TCC	p.P159S	KIAA1543_uc002mgu.3_Missense_Mutation_p.P159S	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	159					epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						CCTGCCAGGTCCCTTGGCCCT	0.622000													20	118					0	0	1	0	0
EVI5L	115704	broad.mit.edu	37	19	7916578	7916578	+	Silent	SNP	C	T	T	rs146356394		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:7916578C>T	uc002min.2	+	8	1063	c.909C>T	c.(907-909)ATC>ATT	p.I303I	EVI5L_uc010xjz.1_Silent_p.I303I|EVI5L_uc002mio.1_Silent_p.I34I	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	303						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GGCTGGAGATCGTGTTCCGAG	0.677000													11	59					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8130905	8130905	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:8130905C>T	uc002mjf.2	-	63	8349	c.8328G>A	c.(8326-8328)GAG>GAA	p.E2776E	FBN3_uc002mje.2_Silent_p.E572E	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2776						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGCTCACCACCTCCAGCCGGT	0.667000													15	62					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8539104	8539104	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:8539104G>A	uc010dwe.2	+	12	1176	c.1096G>A	c.(1096-1098)GGG>AGG	p.G366R	HNRNPM_uc010dwc.1_Missense_Mutation_p.G351R|HNRNPM_uc010xke.1_Missense_Mutation_p.G312R|HNRNPM_uc010dwd.2_Missense_Mutation_p.G327R|HNRNPM_uc002mka.2_Missense_Mutation_p.G231R	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	366					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						ATTTGGATCTGGGATGAACAT	0.493000													32	154					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8995651	8995651	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:8995651C>T	uc002mkp.2	-	63	41541	c.41337G>A	c.(41335-41337)TCG>TCA	p.S13779S	MUC16_uc010dwi.2_Intron|MUC16_uc010dwj.2_Silent_p.S596S|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13781	Extracellular (Potential).|ANK 1.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCCAAATATCGAGGCTGGAG	0.463000													6	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8999056	8999056	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:8999056G>A	uc002mkp.2	-	57	40992	c.40788C>T	c.(40786-40788)TTC>TTT	p.F13596F	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Silent_p.F413F|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13598	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCGCTGTGTGAAACCTGCAT	0.537000													11	40					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8999545	8999545	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:8999545C>T	uc002mkp.2	-	56	40834	c.40630G>A	c.(40630-40632)GCC>ACC	p.A13544T	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.A361T|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13546	SEA 10.|Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACTTTGGTGGCTGCCCCATCC	0.592000													18	68					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059785	9059785	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9059785C>T	uc002mkp.2	-	3	27865	c.27661G>A	c.(27661-27663)GAG>AAG	p.E9221K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9223	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCCAGTTTCTCTGTATCTGTA	0.468000													7	79					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064403	9064403	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9064403C>T	uc002mkp.2	-	3	23247	c.23043G>A	c.(23041-23043)GTG>GTA	p.V7681V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7683	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTTTCTTTCACAAAGGGAG	0.547000													14	47					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068247	9068247	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9068247C>T	uc002mkp.2	-	3	19403	c.19199G>A	c.(19198-19200)AGA>AAA	p.R6400K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6402	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGTTCTGTTCTGGAGACCTC	0.498000													12	50					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9075392	9075392	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9075392C>T	uc002mkp.2	-	3	12258	c.12054G>A	c.(12052-12054)AGG>AGA	p.R4018R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4020	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCTGACGTCCCTCAGTTCAA	0.473000													10	50					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077118	9077118	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9077118G>A	uc002mkp.2	-	3	10532	c.10328C>T	c.(10327-10329)TCT>TTT	p.S3443F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3444	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACATCAGGAGATGCACCAAG	0.478000													13	52					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089119	9089119	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9089119G>A	uc002mkp.2	-	1	2900	c.2696C>T	c.(2695-2697)CCC>CTC	p.P899L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	899	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCCATGGTGGGGAATACTGG	0.512000													6	13					0	0	1	0	0
OR7G1	125962	broad.mit.edu	37	19	9225965	9225965	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9225965G>A	uc002mks.1	-	1	475	c.475C>T	c.(475-477)CAG>TAG	p.Q159*		NM_001005192	NP_001005192	Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						ATCAGACTCTGAACCAGGGCA	0.478000													17	78					0	0	1	0	0
ZNF266	10781	broad.mit.edu	37	19	9525116	9525116	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9525116C>T	uc002mll.2	-	4	751	c.485G>A	c.(484-486)GGG>GAG	p.G162E	ZNF266_uc002mlm.2_Missense_Mutation_p.G162E|ZNF266_uc002mln.2_Missense_Mutation_p.G162E|ZNF266_uc002mlo.2_Missense_Mutation_p.G162E|ZNF266_uc010dwp.2_Missense_Mutation_p.G162E|ZNF266_uc010dwq.2_Missense_Mutation_p.G162E	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	162	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAAGGATTTCCCAGAGTCACT	0.433000													25	89					0	0	1	0	0
FBXL12	54850	broad.mit.edu	37	19	9921728	9921728	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:9921728G>A	uc002mme.2	-	3	1067	c.825C>T	c.(823-825)CTC>CTT	p.L275L	FBXL12_uc002mmd.2_Silent_p.L222L|FBXL12_uc002mmf.2_Silent_p.L222L|FBXL12_uc002mmg.2_Silent_p.L222L|FBXL12_uc002mmh.2_Silent_p.L222L	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	275	LRR 8.						protein binding			lung(1)|kidney(1)	2						GGCAGGAGGAGAGGATTTCAG	0.652000													6	27					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10089286	10089286	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:10089286C>T	uc002mmq.1	-	41	3068	c.2982G>A	c.(2980-2982)AAG>AAA	p.K994K		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	994	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCTTATCACCCTTTAAGCCAG	0.577000													4	45					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11169017	11169017	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:11169017C>T	uc002mqf.3	+	31	4795	c.4511C>T	c.(4510-4512)CCC>CTC	p.P1504L	SMARCA4_uc010dxp.2_Missense_Mutation_p.P1504L|SMARCA4_uc010dxo.2_Missense_Mutation_p.P1536L|SMARCA4_uc010dxq.2_Missense_Mutation_p.P1471L|SMARCA4_uc010dxr.2_Missense_Mutation_p.P1470L|SMARCA4_uc002mqj.3_Missense_Mutation_p.P1474L|SMARCA4_uc010dxs.2_Missense_Mutation_p.P1473L|SMARCA4_uc002mqh.3_Missense_Mutation_p.P594L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1504	Bromo.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ATCCGCAAGCCCGTGGACTTC	0.612000			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				9	58					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11224014	11224014	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:11224014G>A	uc002mqk.3	+	9	1415	c.1247G>A	c.(1246-1248)CGG>CAG	p.R416Q	LDLR_uc010xlk.1_Missense_Mutation_p.R416Q|LDLR_uc010xll.1_Missense_Mutation_p.R375Q|LDLR_uc010xlm.1_Missense_Mutation_p.R269Q|LDLR_uc010xln.1_Missense_Mutation_p.R289Q|LDLR_uc010xlo.1_Missense_Mutation_p.R248Q	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	416	LDL-receptor class B 1.|Extracellular (Potential).		R -> Q (in FH; German patient).|R -> W (in FH).		cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	ACGCTGGACCGGAGCGAGTAC	0.622000													18	68					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397441	13397441	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:13397441G>A	uc010dze.2	-	20	3668	c.3432C>T	c.(3430-3432)AGC>AGT	p.S1144S	CACNA1A_uc010dzc.2_Silent_p.S669S|CACNA1A_uc002mwy.3_Silent_p.S1143S|CACNA1A_uc010xne.1_Silent_p.S672S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1144	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TGACGATAAGGCTATTCTCGG	0.662000													10	37					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14705449	14705449	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:14705449G>A	uc010dzn.1	+	6	393	c.316G>A	c.(316-318)GAA>AAA	p.E106K	CLEC17A_uc002mzh.1_Missense_Mutation_p.E89K|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Missense_Mutation_p.E106K|CLEC17A_uc010dzo.1_Missense_Mutation_p.E106K			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	106	Cytoplasmic (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						CTCAGCAAAGGAAACAGAGAA	0.582000													7	45					0	0	1	0	0
CLEC17A	388512	broad.mit.edu	37	19	14705470	14705470	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:14705470C>T	uc010dzn.1	+	6	414	c.337C>T	c.(337-339)CCT>TCT	p.P113S	CLEC17A_uc002mzh.1_Missense_Mutation_p.P96S|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Missense_Mutation_p.P113S|CLEC17A_uc010dzo.1_Missense_Mutation_p.P113S			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	113	Cytoplasmic (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						ACCCCCACTTCCTTGCAAGCC	0.557000													11	42					0	0	1	0	0
EMR3	84658	broad.mit.edu	37	19	14765819	14765819	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:14765819G>A	uc002mzi.3	-	6	700	c.552C>T	c.(550-552)GTC>GTT	p.V184V	EMR3_uc010dzp.2_Silent_p.V132V|EMR3_uc010xnv.1_Intron	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	184	Extracellular (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						GGATTTTCAGGACTTTTTGTT	0.433000													17	87					0	0	1	0	0
ZNF333	84449	broad.mit.edu	37	19	14826998	14826998	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:14826998G>A	uc002mzn.2	+	9	809	c.675G>A	c.(673-675)AGG>AGA	p.R225R	ZNF333_uc002mzk.3_Silent_p.R116R|ZNF333_uc010dzr.1_RNA	NM_032433	NP_115809	Q96JL9	ZN333_HUMAN	zinc finger protein 333	225	KRAB 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTACTCAGAGGAGCCTGTATA	0.433000													27	111					0	0	1	0	0
OR7C2	26658	broad.mit.edu	37	19	15052838	15052838	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:15052838G>A	uc010xoc.1	+	1	538	c.538G>A	c.(538-540)GAT>AAT	p.D180N		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					CTTTTTTTGTGATCCTTCCGA	0.468000													28	132					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15072869	15072869	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:15072869C>T	uc002naa.1	-	5	888	c.880G>A	c.(880-882)GAC>AAC	p.D294N	SLC1A6_uc010dzu.1_Missense_Mutation_p.D294N|SLC1A6_uc010xod.1_Missense_Mutation_p.D230N|SLC1A6_uc002nab.2_Missense_Mutation_p.D294N|SLC1A6_uc002nac.2_Missense_Mutation_p.D294N	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	294					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	TCGAAGAAGTCCCTGAGGACT	0.582000													18	79					0	0	1	0	0
CASP14	23581	broad.mit.edu	37	19	15166261	15166261	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:15166261G>A	uc010dzv.1	+	6	849	c.541G>A	c.(541-543)GAT>AAT	p.D181N	CASP14_uc002naf.2_Missense_Mutation_p.D181N	NM_012114	NP_036246	P31944	CASPE_HUMAN	caspase 14 precursor	181					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity			skin(2)|ovary(1)|lung(1)	4						CTACCGACATGATCAGAAAGG	0.527000													14	88					0	0	1	0	0
CYP4F8	11283	broad.mit.edu	37	19	15740024	15740024	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:15740024C>T	uc002nbi.2	+	15	1483	c.1419C>T	c.(1417-1419)TTC>TTT	p.F473F	CYP4F8_uc010xoj.1_Silent_p.F285F	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	473					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						GGCAGAAGTTCGCGATGGCAG	0.657000													3	19					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15791299	15791299	+	Silent	SNP	G	A	A	rs141478890		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:15791299G>A	uc002nbl.2	+	5	556	c.495G>A	c.(493-495)ACG>ACA	p.T165T	CYP4F12_uc010xoo.1_Silent_p.T165T|CYP4F12_uc010xop.1_3'UTR	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,									p.T165T(1)		skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CCTATATAACGATCTTCAACA	0.493000													11	49					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16024612	16024612	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:16024612G>A	uc002nbu.2	-	13	1541	c.1505C>T	c.(1504-1506)CCC>CTC	p.P502L	CYP4F11_uc010eab.1_3'UTR|CYP4F11_uc002nbt.2_Missense_Mutation_p.P502L	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	502					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						TATCAGCTCGGGTTTCCTGCG	0.632000													15	52					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16040396	16040396	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:16040396C>T	uc002nbu.2	-	3	250	c.214G>A	c.(214-216)GAG>AAG	p.E72K	CYP4F11_uc010eab.1_Missense_Mutation_p.E72K|CYP4F11_uc002nbt.2_Missense_Mutation_p.E72K	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	72					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						TTCATGCCCTCTTCCGTGGGA	0.403000													30	121					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16918508	16918508	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:16918508C>T	uc002neu.3	+	18	4270	c.3848C>T	c.(3847-3849)CCC>CTC	p.P1283L	NWD1_uc002net.3_Missense_Mutation_p.P1148L|NWD1_uc002nev.3_Missense_Mutation_p.P1077L			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1283	WD 11.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CTTGTGTTCCCCCTGAATTCC	0.597000													15	58					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17837489	17837489	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:17837489C>T	uc002nhe.1	+	5	1305	c.1296C>T	c.(1294-1296)TTC>TTT	p.F432F	MAP1S_uc010eaz.1_RNA|MAP1S_uc010eba.1_Silent_p.F432F|MAP1S_uc002nhf.1_Intron|MAP1S_uc010xpv.1_Silent_p.F406F	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	BPY2 interacting protein 1	432	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			central_nervous_system(1)	1						GCGTGCTGTTCCCCGGTTGCA	0.751000													3	8					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18377400	18377400	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:18377400G>A	uc002nin.2	-	3	1166	c.950C>T	c.(949-951)CCT>CTT	p.P317L	KIAA1683_uc010ebn.2_Missense_Mutation_p.P317L|KIAA1683_uc010xqe.1_Missense_Mutation_p.P271L	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	317						mitochondrion				ovary(2)	2						TGCTTTCACAGGGCCCTGGGT	0.572000													11	96					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19654548	19654548	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:19654548G>A	uc002nmv.3	+	8	1279	c.1194G>A	c.(1192-1194)GAG>GAA	p.E398E	CILP2_uc002nmw.3_Silent_p.E404E	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	398						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						AGCTCCCTGAGGACTGTGGTC	0.687000													77	280					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19655067	19655067	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:19655067C>T	uc002nmv.3	+	8	1798	c.1713C>T	c.(1711-1713)CCC>CCT	p.P571P	CILP2_uc002nmw.3_Silent_p.P577P	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	571						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						ACACGATCCCCCTGGGCGAGC	0.632000													23	155					0	0	1	0	0
ZNF682	91120	broad.mit.edu	37	19	20117876	20117876	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:20117876G>A	uc002noq.2	-	4	558	c.435C>T	c.(433-435)TTC>TTT	p.F145F	ZNF682_uc002noo.2_Silent_p.F113F|ZNF682_uc002nop.2_Silent_p.F113F|ZNF682_uc010eck.2_Silent_p.F69F	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	145					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TATTATATGGGAAAATTTTGC	0.308000													11	45					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727979	20727979	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:20727979C>T	uc002npa.2	-	4	1210	c.1030G>A	c.(1030-1032)GAA>AAA	p.E344K		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	344					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CCACATTCTTCACATTTGTAG	0.403000													10	38					0	0	1	0	0
ZNF431	170959	broad.mit.edu	37	19	21366594	21366594	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:21366594C>T	uc002npp.2	+	5	1635	c.1488C>T	c.(1486-1488)TCC>TCT	p.S496S	ZNF431_uc010ecq.2_Silent_p.S405S|ZNF431_uc010ecr.2_Silent_p.S497S	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	496	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						TTAACCGATCCTCAAATCTTA	0.353000													11	49					0	0	1	0	0
ZNF493	284443	broad.mit.edu	37	19	21605873	21605873	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:21605873G>A	uc002npx.2	+	2	308	c.28G>A	c.(28-30)GGT>AGT	p.G10S	ZNF493_uc002npw.2_Missense_Mutation_p.G138S|ZNF493_uc002npy.2_Missense_Mutation_p.G10S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCACAAAGAAGGTTATAATGA	0.284000													16	79					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22170085	22170085	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:22170085G>A	uc002nqp.2	-	3	308	c.159C>T	c.(157-159)ATC>ATT	p.I53I	ZNF208_uc002nqo.1_Silent_p.I53I|ZNF208_uc002nqq.2_RNA	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCAGAAAAATGATCAGGTCTG	0.403000													9	59					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22271732	22271732	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:22271732C>T	uc010ecx.2	+	4	1349	c.1180C>T	c.(1180-1182)CAT>TAT	p.H394Y	ZNF257_uc010ecy.2_Missense_Mutation_p.H362Y	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	394	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAAGAGAATTCATACTAGAGA	0.363000													6	15					0	0	1	0	0
ZNF675	171392	broad.mit.edu	37	19	23837302	23837302	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:23837302G>A	uc002nri.2	-	4	615	c.433C>T	c.(433-435)CAA>TAA	p.Q145*		NM_138330	NP_612203	Q8TD23	ZN675_HUMAN	zinc finger protein 675	145	C2H2-type 1; degenerate.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|kidney(1)	2		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTATCACATTGAAACATTTTG	0.303000													10	28					0	0	1	0	0
Unknown	0	broad.mit.edu	37	19	24102881	24102881	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:24102881C>T	uc002nrp.1	-	3		c.587G>A			uc010eda.1_RNA					Homo sapiens cDNA FLJ43698 fis, clone TCERX2000998.																		GGATGAACCCCCAGGTAGGTG	0.448000													11	47					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039473	31039473	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:31039473G>A	uc002nsu.1	+	4	3085	c.2947G>A	c.(2947-2949)GAT>AAT	p.D983N	ZNF536_uc010edd.1_Missense_Mutation_p.D983N	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	983					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGTGCGGCCAGATGCCGCCTC	0.577000													28	139					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32847604	32847604	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:32847604C>T	uc002nte.2	+	4	2482	c.2210C>T	c.(2209-2211)TCC>TTC	p.S737F	ZNF507_uc002ntc.2_Missense_Mutation_p.S737F|ZNF507_uc010xrn.1_Missense_Mutation_p.S737F|ZNF507_uc002ntd.2_Missense_Mutation_p.S737F	NM_001136156	NP_001129628	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|kidney(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(110;0.162)					CCAAGAATTTCCAGTGATACA	0.403000													15	56					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33098694	33098694	+	Silent	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:33098694G>T	uc002ntn.1	-	23	2376	c.2220C>A	c.(2218-2220)ACC>ACA	p.T740T		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	740					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					CGTCCTGGCTGGTCACGTTCA	0.632000													4	20					1	1	1	1	0
LSR	51599	broad.mit.edu	37	19	35757365	35757365	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:35757365G>A	uc002nyl.2	+	6	1249	c.1026G>A	c.(1024-1026)ATG>ATA	p.M342I	LSR_uc002nym.2_Missense_Mutation_p.M323I|LSR_uc002nyn.2_Missense_Mutation_p.M274I|LSR_uc002nyo.2_Missense_Mutation_p.M323I|LSR_uc010xsr.1_Missense_Mutation_p.M234I|LSR_uc002nyp.2_Missense_Mutation_p.M305I|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	342	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CACCAGCTATGATTCCCATGG	0.622000													20	106					0	0	1	0	0
WDR62	284403	broad.mit.edu	37	19	36587934	36587934	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:36587934C>T	uc002odc.2	+	21	2564	c.2473C>T	c.(2473-2475)CGT>TGT	p.R825C	WDR62_uc002odd.2_Missense_Mutation_p.R825C	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	825	WD 13.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCCAGATCCTCGTTGCCTGCT	0.353000													7	30					0	0	1	0	0
ZNF829	374899	broad.mit.edu	37	19	37405908	37405908	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:37405908C>T	uc002ofa.1	-	3	417	c.55G>A	c.(55-57)GAG>AAG	p.E19K	ZNF568_uc010efg.2_5'Flank|ZNF568_uc010xtn.1_5'Flank|ZNF829_uc002ofb.2_Missense_Mutation_p.E19K|ZNF568_uc002ofc.2_5'Flank|ZNF568_uc002ofd.2_5'Flank|ZNF568_uc010efe.2_5'Flank|ZNF568_uc010eff.1_5'Flank	NM_001037232	NP_001032309	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	19	Poly-Glu.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATTCTTTCCTCCTCTTCTGGG	0.408000													11	40					0	0	1	0	0
ZNF527	84503	broad.mit.edu	37	19	37880080	37880080	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:37880080C>T	uc010efk.1	+	5	1240	c.1129C>T	c.(1129-1131)CAG>TAG	p.Q377*	ZNF527_uc002ogf.3_Nonsense_Mutation_p.Q345*|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	377	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGTTGAACATCAGAGAATTCA	0.438000													7	45					0	0	1	0	0
CATSPERG	57828	broad.mit.edu	37	19	38860892	38860892	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:38860892C>T	uc002oih.3	+	28	3294	c.3207C>T	c.(3205-3207)ATC>ATT	p.I1069I	CATSPERG_uc002oig.3_Silent_p.I1029I|CATSPERG_uc002oif.3_Silent_p.I709I|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	1069	Helical; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CCCTTTTCATCATCATGGTGA	0.577000													8	46					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38949939	38949939	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:38949939G>A	uc002oit.2	+	19	2451	c.2321G>A	c.(2320-2322)GGG>GAG	p.G774E	RYR1_uc002oiu.2_Missense_Mutation_p.G774E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	774	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AACCTGGACGGGCTCTTCTTC	0.602000													10	53					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38954406	38954406	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:38954406G>A	uc002oit.2	+	22	2832	c.2702G>A	c.(2701-2703)AGG>AAG	p.R901K	RYR1_uc002oiu.2_Missense_Mutation_p.R901K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	901	1.|Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GACAACAAGAGGCTGCACCCG	0.582000													39	150					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38980751	38980751	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:38980751G>A	uc002oit.2	+	36	5980	c.5850G>A	c.(5848-5850)GAG>GAA	p.E1950E	RYR1_uc002oiu.2_Silent_p.E1950E	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1950	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTGACCAAGAGCTGCAGCACC	0.572000													15	85					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38997005	38997006	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:38997005_38997006CC>TT	uc002oit.2	+	55	8734_8735	c.8604_8605CC>TT	c.(8602-8607)TCCCGG>TCTTGG	p.R2869W	RYR1_uc002oiu.2_Missense_Mutation_p.R2869W|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2869	6 X approximate repeats.|Cytoplasmic.|6.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTACCCTGTCCCGGGAGCTGCA	0.589000													15	93					0	0	1	0	0
ECH1	1891	broad.mit.edu	37	19	39306638	39306638	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:39306638G>A	uc002oji.2	-	9	826	c.741C>T	c.(739-741)TTC>TTT	p.F247F	LGALS4_uc002ojg.2_5'Flank|LGALS4_uc010xuj.1_5'Flank|ECH1_uc002ojh.2_Silent_p.F127F	NM_001398	NP_001389	Q13011	ECH1_HUMAN	peroxisomal enoyl-coenzyme A hydratase-like	247					fatty acid beta-oxidation|generation of precursor metabolites and energy	mitochondrion|peroxisome	enoyl-CoA hydratase activity|isomerase activity|protein binding			ovary(1)	1	all_cancers(60;9.36e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			CTTTGTCTGGGAACACCCGGC	0.612000													8	54					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39962101	39962101	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:39962101C>T	uc002olo.3	+	19	1961	c.1782C>T	c.(1780-1782)ATC>ATT	p.I594I	SUPT5H_uc002olp.3_Silent_p.I594I|SUPT5H_uc002olq.3_Silent_p.I590I|SUPT5H_uc002oln.3_Silent_p.I594I|SUPT5H_uc002olr.3_Silent_p.I594I|SUPT5H_uc002ols.1_Silent_p.I217I|SUPT5H_uc010egp.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	594	KOW 4.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			AGAACAACATCCATGTGAAAG	0.502000													24	87					0	0	1	0	0
Unknown	0	broad.mit.edu	37	19	40151153	40151153	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:40151153G>A	uc010xvd.1	+	4	490	c.422G>A	c.(421-423)CGG>CAG	p.R141Q						SubName: Full=Galectin-16;																		AACAATGGACGGAGATGATCA	0.473000													4	6					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40316606	40316606	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:40316606G>A	uc002omj.2	-	11	1919	c.1639C>T	c.(1639-1641)CGA>TGA	p.R547*	DYRK1B_uc002omi.2_Nonsense_Mutation_p.R519*|DYRK1B_uc002omk.2_Nonsense_Mutation_p.R507*	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	547					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CCAAGGTATCGGGGCTGGGGG	0.687000													23	85					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40363221	40363221	+	Missense_Mutation	SNP	C	T	T	rs140298192		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:40363221C>T	uc002omp.3	-	32	14857	c.14849G>A	c.(14848-14850)CGA>CAA	p.R4950Q		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4950	VWFD 12.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AACCATGTTTCGGCCCTCGGC	0.667000													5	21					0	0	1	0	0
ZNF780A	284323	broad.mit.edu	37	19	40589045	40589045	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:40589045C>T	uc002omy.2	-	4	334	c.109G>A	c.(109-111)GAG>AAG	p.E37K	ZNF780A_uc002omw.3_Missense_Mutation_p.E53K|ZNF780A_uc002omz.2_Missense_Mutation_p.E37K|ZNF780A_uc010xvh.1_Missense_Mutation_p.E37K	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTGTAGTTCTCCAACATCACA	0.478000													21	148					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719928	40719929	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:40719928_40719929CC>TT	uc002ona.2	+	9	2630_2631	c.2342_2343CC>TT	c.(2341-2343)CCC>CTT	p.P781L	MAP3K10_uc002onb.2_Missense_Mutation_p.P170L	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	781					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						ccctccccgcccgcgcccacac	0.490000													3	10					0	0	1	0	0
CYP2F1	1572	broad.mit.edu	37	19	41622176	41622176	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:41622176G>A	uc002opu.1	+	2	139	c.83G>A	c.(82-84)GGA>GAA	p.G28E	CYP2F1_uc010xvw.1_Intron|CYP2F1_uc010xvv.1_Missense_Mutation_p.G28E|CYP2F1_uc002opv.1_RNA	NM_000774	NP_000765	P24903	CP2F1_HUMAN	cytochrome P450, family 2, subfamily F,	28					naphthalene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0						AGAGATAAGGGAAAGCTGCCT	0.562000													35	283					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42794832	42794832	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:42794832G>A	uc002otf.1	+	10	1952	c.1912G>A	c.(1912-1914)GAG>AAG	p.E638K		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	638	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CCCAAACAAGGAGGAGCAAGA	0.692000			T	DUX4	soft tissue sarcoma								9	43					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42848175	42848175	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:42848175T>G	uc002otl.3	+	10	2373	c.1738T>G	c.(1738-1740)TGC>GGC	p.C580G	MEGF8_uc002otm.3_Missense_Mutation_p.C121G	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	580	Extracellular (Potential).|PSI 1.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				ATGCAGTTGGTGCCAAGGAGC	0.632000													17	79					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43244515	43244515	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:43244515G>A	uc002oue.2	-	1	154	c.22C>T	c.(22-24)CCC>TCC	p.P8S	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Missense_Mutation_p.P30S	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	8					defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TGTGTGCAGGGAGGGGCTGAG	0.607000													39	203					0	0	1	0	0
PSG1	5669	broad.mit.edu	37	19	43343528	43343528	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:43343528G>A	uc002our.1	-	6	1384	c.1246C>T	c.(1246-1248)CCT>TCT	p.P416S	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Missense_Mutation_p.P329S|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Missense_Mutation_p.P142S|PSG10_uc002ouv.1_Intron|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron|PSG10_uc010eip.2_RNA|PSG1_uc010eio.1_Intron	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	Error:Variant_position_missing_in_P11464_after_alignment					female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				ATTCCTGGAGGAGCTGTCATG	0.423000													12	44					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43411865	43411865	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:43411865G>A	uc002ovj.1	-	4	900	c.848C>T	c.(847-849)CCG>CTG	p.P283L	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.P290L|PSG6_uc002ovi.2_Missense_Mutation_p.P284L|PSG6_uc010xwk.1_Missense_Mutation_p.P123L|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_Missense_Mutation_p.P73L|PSG6_uc002ovf.1_Intron|PSG6_uc002ovg.1_Missense_Mutation_p.P283L	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	283	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				CTTTACCCTCGGACTGACCGG	0.488000													65	285					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43762487	43762487	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:43762487C>T	uc002owd.3	-	5	1209	c.1110G>A	c.(1108-1110)GGG>GGA	p.G370G	PSG9_uc002owe.3_Silent_p.G277G|PSG9_uc010xwm.1_Silent_p.G277G|PSG9_uc002owf.3_Silent_p.G184G|PSG9_uc002owg.2_Silent_p.G277G|PSG9_uc002owh.2_Silent_p.G184G	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	370	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GCTGAAACTTCCCATTAATTG	0.443000													41	266					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43864489	43864489	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:43864489C>T	uc002owi.2	+	6	734	c.692C>T	c.(691-693)ACC>ATC	p.T231I	CD177_uc010eis.2_RNA|CD177_uc002owj.2_RNA	NM_020406	NP_065139	Q8N6Q3	CD177_HUMAN	CD177 molecule precursor	231					blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)	1		Prostate(69;0.00682)				ACTGATTGGACCACATCGAAT	0.542000													8	13					0	0	1	0	0
CADM4	199731	broad.mit.edu	37	19	44127496	44127496	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:44127496C>T	uc002oxc.1	-	9	1202	c.1153G>A	c.(1153-1155)GAA>AAA	p.E385K		NM_145296	NP_660339	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4 precursor	385	Cytoplasmic (Potential).				cell adhesion	integral to membrane					0		Prostate(69;0.0199)				ATGAAGAATTCCTCTTTCCTC	0.577000													30	139					0	0	1	0	0
IRGC	56269	broad.mit.edu	37	19	44223004	44223004	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:44223004C>T	uc002oxh.2	+	2	441	c.294C>T	c.(292-294)CCC>CCT	p.P98P		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	98						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				AACCGTCGCCCTATCCACACC	0.647000													14	53					0	0	1	0	0
CEACAM20	125931	broad.mit.edu	37	19	45028187	45028187	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:45028187C>T	uc010ejn.1	-	3	320	c.304G>A	c.(304-306)GTT>ATT	p.V102I	CEACAM20_uc010ejo.1_Missense_Mutation_p.V102I|CEACAM20_uc010ejp.1_Missense_Mutation_p.V102I|CEACAM20_uc010ejq.1_Missense_Mutation_p.V102I	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	102	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				TTGTTGGAAACCCAGTGGATG	0.537000													8	32					0	0	1	0	0
GEMIN7	79760	broad.mit.edu	37	19	45593548	45593548	+	Missense_Mutation	SNP	G	A	A	rs147899933		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:45593548G>A	uc002pap.1	+	3	327	c.176G>A	c.(175-177)CGA>CAA	p.R59Q	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Missense_Mutation_p.R59Q|GEMIN7_uc002par.1_Missense_Mutation_p.R59Q	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	59					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		CAGCGGGCACGAGCCGCCCTT	0.632000													12	36					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47278996	47278996	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:47278996G>A	uc002pfs.2	-	8	2017	c.1397C>T	c.(1396-1398)TCC>TTC	p.S466F	SLC1A5_uc010xyh.1_Missense_Mutation_p.S264F|SLC1A5_uc002pfq.2_Missense_Mutation_p.S290F|SLC1A5_uc002pfr.2_Missense_Mutation_p.S238F	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	466					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	GACGGTACAGGACCGGTCGCT	0.567000													4	54					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47285791	47285791	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:47285791C>T	uc002pfs.2	-	4	1293	c.673G>A	c.(673-675)GAG>AAG	p.E225K	SLC1A5_uc010xyh.1_Missense_Mutation_p.E23K|SLC1A5_uc002pfq.2_Missense_Mutation_p.E49K|SLC1A5_uc002pfr.2_5'UTR	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	225	Helical; (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	CCCTCCACCTCCTGCCCCACG	0.522000													23	109					0	0	1	0	0
GPR77	27202	broad.mit.edu	37	19	47844800	47844800	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:47844800C>T	uc010ela.1	+	2	962	c.744C>T	c.(742-744)CCC>CCT	p.P248P	GPR77_uc002pgk.1_Silent_p.P248P	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	248	Helical; Name=6; (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GCTGGGCACCCTACCACCTGC	0.701000													15	58					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47969382	47969382	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:47969382G>A	uc002pgx.2	-	2	557	c.279C>T	c.(277-279)TTC>TTT	p.F93F	SLC8A2_uc010xyq.1_Intron|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Silent_p.F93F	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	93	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		TGGCCGCCATGAAACGGTCGG	0.582000													20	103					0	0	1	0	0
SEC1	653677	broad.mit.edu	37	19	49183689	49183689	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:49183689C>T	uc010xzv.1	+	5	836	c.709C>T	c.(709-711)CCG>TCG	p.P237S	SEC1_uc002pka.2_Missense_Mutation_p.P197S|SEC1_uc010xzw.1_Missense_Mutation_p.P154S|SEC1_uc010ema.2_Missense_Mutation_p.P143S	NR_004401				SubName: Full=cDNA FLJ58287, highly similar to Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69);												0						CCGCCACATCCCGGGGCGCTG	0.652000													13	67					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49657579	49657579	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:49657579C>T	uc002pmv.2	-	1	1103	c.916G>A	c.(916-918)GAT>AAT	p.D306N		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	306	4 X tandem repeats, acidic.|1-3.|6 X approximate tandem repeats.				muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TCATCATCATCATTGTCATCT	0.532000													14	60					0	0	1	0	0
CD37	951	broad.mit.edu	37	19	49841189	49841189	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:49841189G>A	uc002pnd.2	+	5	471	c.350G>A	c.(349-351)CGA>CAA	p.R117Q	uc002pnb.1_Intron|CD37_uc002pnc.2_RNA|CD37_uc010yam.1_Missense_Mutation_p.R117Q|CD37_uc010yan.1_Missense_Mutation_p.R49Q|CD37_uc002pnf.3_Missense_Mutation_p.R89Q|CD37_uc002pne.2_Missense_Mutation_p.R49Q	NM_001774	NP_001765	P11049	CD37_HUMAN	CD37 antigen isoform A	117	Extracellular (Potential).					integral to membrane					0		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		CAGCTGGAGCGAAGCTTGCGG	0.637000													16	63					0	0	1	0	0
BCL2L12	83596	broad.mit.edu	37	19	50169131	50169131	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:50169131C>T	uc002ppa.2	+	1	733	c.51C>T	c.(49-51)TTC>TTT	p.F17F	IRF3_uc002pot.1_5'Flank|IRF3_uc010end.1_5'Flank|IRF3_uc002pox.1_5'Flank|IRF3_uc002poy.1_5'Flank|IRF3_uc002pou.2_5'UTR|IRF3_uc002pov.2_5'UTR|IRF3_uc002pow.2_5'UTR|IRF3_uc002poz.1_5'Flank|IRF3_uc010ene.1_5'Flank|BCL2L12_uc002ppb.2_Silent_p.F17F	NM_138639	NP_619580	Q9HB09	B2L12_HUMAN	BCL2-like 12 isoform 1	17					apoptosis					central_nervous_system(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.000681)|GBM - Glioblastoma multiforme(134;0.0214)		TTTTGGGTTTCCGGCCAGAGG	0.572000													15	45					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50760612	50760612	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:50760612G>A	uc002prr.1	+	16	2025	c.1978G>A	c.(1978-1980)GGC>AGC	p.G660S	MYH14_uc010enu.1_Missense_Mutation_p.G701S|MYH14_uc002prq.1_Missense_Mutation_p.G668S	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	660	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CCCACCAGGTGGCCGCCCCCG	0.627000													4	15					0	0	1	0	0
KCNC3	3748	broad.mit.edu	37	19	50826886	50826886	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:50826886G>A	uc002pru.1	-	2	1619	c.1324C>T	c.(1324-1326)CGC>TGC	p.R442C	KCNC3_uc002prt.1_Missense_Mutation_p.R78C	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	442	Cytoplasmic (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GTGCTGGCGCGGAGCGTGTGT	0.642000													17	67					0	0	1	0	0
FAM71E1	112703	broad.mit.edu	37	19	50978600	50978600	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:50978600C>T	uc002psh.2	-	3	879	c.521G>A	c.(520-522)GGA>GAA	p.G174E	FAM71E1_uc002psg.2_Missense_Mutation_p.G158E|FAM71E1_uc002psi.2_RNA|C19orf63_uc002psj.2_5'Flank|C19orf63_uc002psk.2_5'Flank|C19orf63_uc002psl.2_5'Flank	NM_138411	NP_612420	Q6IPT2	F71E1_HUMAN	hypothetical protein LOC112703	174										breast(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		TTGCAGGTGTCCGTTCTCCTT	0.652000													11	33					0	0	1	0	0
LRRC4B	94030	broad.mit.edu	37	19	51021747	51021747	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:51021747G>A	uc002pss.2	-	3	1360	c.1223C>T	c.(1222-1224)TCC>TTC	p.S408F		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	408	Extracellular (Potential).|Ig-like C2-type.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		CACGCGGTAGGAGCCGTGGGT	0.632000													8	40					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51503514	51503514	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:51503514C>T	uc002pur.1	-	4	410	c.231G>A	c.(229-231)CCG>CCA	p.P77P	KLK8_uc002puq.1_Silent_p.P122P|KLK8_uc002pus.1_Intron|KLK8_uc002put.1_Intron|KLK8_uc002puu.1_Silent_p.P77P|KLK9_uc002puv.1_Intron	NM_007196	NP_009127	O60259	KLK8_HUMAN	kallikrein 8 isoform 1 preproprotein	77	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		CTGTGTATTTCCTGTAATGGT	0.368000													40	142					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51738480	51738480	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:51738480G>A	uc002pwa.2	+	5	854	c.814G>A	c.(814-816)GCT>ACT	p.A272T	CD33_uc010eos.1_Missense_Mutation_p.A272T|CD33_uc010eot.1_Missense_Mutation_p.A145T|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	272	Helical; (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	AGCCCTGCTCGCTCTTTGTCT	0.522000													16	46					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52001304	52001304	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:52001304G>A	uc002pwx.1	-	5	1429	c.1373C>T	c.(1372-1374)TCC>TTC	p.S458F	SIGLEC12_uc002pww.1_Missense_Mutation_p.S340F|SIGLEC12_uc010eoy.1_Missense_Mutation_p.S185F	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	458	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GAGGCTCAGGGAAATGTGCTG	0.592000													11	69					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52004611	52004611	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:52004611C>T	uc002pwx.1	-	1	433	c.377G>A	c.(376-378)GGA>GAA	p.G126E	SIGLEC12_uc002pww.1_5'Flank|SIGLEC12_uc010eoy.1_5'UTR	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	126	Ig-like V-type 1.|Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TTTCATATTTCCTCTCTCTAC	0.473000													13	96					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034741	52034741	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:52034741C>T	uc002pwy.2	-	2	262	c.100G>A	c.(100-102)GAG>AAG	p.E34K	SIGLEC6_uc002pwz.2_Missense_Mutation_p.E34K|SIGLEC6_uc002pxa.2_Missense_Mutation_p.E34K|SIGLEC6_uc010ydb.1_Intron|SIGLEC6_uc010ydc.1_Missense_Mutation_p.E23K|SIGLEC6_uc010eoz.1_Missense_Mutation_p.E23K|SIGLEC6_uc010epb.1_Intron|SIGLEC6_uc010epa.1_Missense_Mutation_p.E23K	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	34	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TCTGGCCCCTCCAGCTGGAAT	0.642000													13	56					0	0	1	0	0
FPR2	2358	broad.mit.edu	37	19	52271984	52271984	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:52271984C>T	uc002pxr.2	+	2	118	c.73C>T	c.(73-75)CTG>TTG	p.L25L	FPR2_uc002pxs.3_Silent_p.L25L|FPR2_uc010epf.2_Silent_p.L25L	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	25	Extracellular (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						CTACACTGTTCTGCGGATCCT	0.532000													17	99					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52520153	52520153	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:52520153C>T	uc002pyj.2	-	5	1100	c.698G>A	c.(697-699)GGA>GAA	p.G233E	ZNF614_uc002pyi.3_Intron|ZNF614_uc010epj.2_5'UTR	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TTGACCACTTCCAGGATTCTC	0.363000													18	53					0	0	1	0	0
ZNF614	80110	broad.mit.edu	37	19	52521264	52521264	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:52521264G>A	uc002pyj.2	-	4	637	c.235C>T	c.(235-237)CCA>TCA	p.P79S	ZNF614_uc002pyi.3_Missense_Mutation_p.P79S|ZNF614_uc010epj.2_5'UTR	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	79	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CACTTACCTGGACAATTTTTA	0.403000													4	22					0	0	1	0	0
ZNF766	90321	broad.mit.edu	37	19	52793753	52793753	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:52793753C>T	uc002pyr.1	+	4	752	c.709C>T	c.(709-711)CGT>TGT	p.R237C	ZNF766_uc002pys.1_3'UTR|ZNF766_uc002pyt.1_Missense_Mutation_p.R252C	NM_001010851	NP_001010851	Q5HY98	ZN766_HUMAN	zinc finger protein 766	237	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		TTGGAGAATTCGTACAGGAGA	0.438000													16	26					0	0	1	0	0
ZNF331	55422	broad.mit.edu	37	19	54081049	54081049	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:54081049G>T	uc002qbx.1	+	7	2669	c.1235G>T	c.(1234-1236)GGG>GTG	p.G412V	ZNF331_uc002qby.1_Missense_Mutation_p.G412V|ZNF331_uc002qbz.1_Missense_Mutation_p.G412V|ZNF331_uc002qca.1_Missense_Mutation_p.G412V|ZNF331_uc010eqr.1_Missense_Mutation_p.G412V|ZNF331_uc002qcb.1_Missense_Mutation_p.G412V|ZNF331_uc002qcc.1_Missense_Mutation_p.G412V|ZNF331_uc002qcd.1_Missense_Mutation_p.G412V	NM_018555	NP_061025	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	412	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)	6				GBM - Glioblastoma multiforme(134;0.00555)		AAACCCTATGGGTGTACAGAA	0.488000			T	?	follicular thyroid adenoma								7	40					5.18039e-06	5.21186e-06	1	1	0
NLRP12	91662	broad.mit.edu	37	19	54307284	54307284	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:54307284C>T	uc002qch.3	-	6	2727	c.2507G>A	c.(2506-2508)GGA>GAA	p.G836E	NLRP12_uc010eqw.2_Missense_Mutation_p.G119E|NLRP12_uc002qci.3_Missense_Mutation_p.G836E|NLRP12_uc002qcj.3_Missense_Mutation_p.G837E|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.G837E	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	836	LRR 1.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAGTGCATTTCCTGTCAGGTC	0.562000													6	62					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55107696	55107696	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:55107696C>T	uc002qgh.1	+	7	1183	c.1001C>T	c.(1000-1002)CCC>CTC	p.P334L	LILRA2_uc010yfg.1_Missense_Mutation_p.P332L|LILRA1_uc010yfh.1_Missense_Mutation_p.P334L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	334	Ig-like C2-type 4.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CATCCGGGCCCCACGGTGGCC	0.627000													16	70					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55331325	55331325	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:55331325C>T	uc002qhk.3	+	4	576	c.513C>T	c.(511-513)ATC>ATT	p.I171I	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Silent_p.I113I|KIR3DL1_uc010esf.2_Silent_p.I76I|KIR3DL1_uc010yfo.1_Silent_p.I113I|KIR3DL1_uc002qhl.3_Silent_p.I171I	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	171	Extracellular (Potential).|Ig-like C2-type 2.				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		TTGGACAGATCCATGATGGGG	0.512000													44	218					0	0	1	0	0
NCR1	9437	broad.mit.edu	37	19	55417910	55417910	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:55417910G>A	uc002qib.2	+	3	138	c.100G>A	c.(100-102)GAG>AAG	p.E34K	NCR1_uc002qic.2_Missense_Mutation_p.E34K|NCR1_uc002qie.2_Missense_Mutation_p.E34K|NCR1_uc002qid.2_Intron|NCR1_uc002qif.2_Intron|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	34	Ig-like 1.|Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CATCTGGGCCGAGCCCCATTT	0.542000													27	96					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494101	55494101	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:55494101G>A	uc002qij.2	+	6	1121	c.1035G>A	c.(1033-1035)CGG>CGA	p.R345R	NLRP2_uc010yfp.1_Silent_p.R322R|NLRP2_uc010esn.2_Silent_p.R321R|NLRP2_uc010eso.2_Silent_p.R342R|NLRP2_uc010esp.2_Silent_p.R323R	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	345	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGGACCTCCGGATCCTGGCGG	0.637000													4	26					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56482009	56482009	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:56482009C>T	uc002qmh.2	+	6	2552	c.2481C>T	c.(2479-2481)TCC>TCT	p.S827S	NLRP8_uc010etg.2_Silent_p.S827S	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	827	LRR 2.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAAAAAACTCCCTGGAGAACT	0.498000													25	163					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56482034	56482034	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:56482034C>T	uc002qmh.2	+	6	2577	c.2506C>T	c.(2506-2508)CTG>TTG	p.L836L	NLRP8_uc010etg.2_Silent_p.L836L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	836	LRR 2.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GGCGTATTACCTGTCTGTGGC	0.463000													23	176					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57334199	57334199	+	Missense_Mutation	SNP	G	A	A	rs151090043		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:57334199G>A	uc002qnu.2	-	3	838	c.487C>T	c.(487-489)CGG>TGG	p.R163W	ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnr.2_Missense_Mutation_p.R38W|ZIM2_uc002qnq.2_Missense_Mutation_p.R38W|ZIM2_uc010etp.2_Missense_Mutation_p.R38W|ZIM2_uc010ygs.1_Missense_Mutation_p.R38W|PEG3_uc002qnt.2_Missense_Mutation_p.R164W|PEG3_uc002qnv.2_Missense_Mutation_p.R163W|PEG3_uc002qnw.2_Missense_Mutation_p.R38W|PEG3_uc002qnx.2_Missense_Mutation_p.R37W|PEG3_uc010etr.2_Missense_Mutation_p.R163W	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	163					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TCCCAGTCCCGGTCACCTAAG	0.532000													3	16					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640376	57640376	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:57640376G>A	uc002qny.2	+	4	689	c.333G>A	c.(331-333)ATG>ATA	p.M111I		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	111					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGCAACCCATGAAATCTGATG	0.353000													9	63					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642615	57642615	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:57642615G>A	uc002qny.2	+	4	2928	c.2572G>A	c.(2572-2574)GAT>AAT	p.D858N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	858					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACATACAACGATCTATGTGT	0.453000													8	29					0	0	1	0	0
DUXA	503835	broad.mit.edu	37	19	57666650	57666650	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:57666650G>A	uc002qoa.1	-	5	574	c.529C>T	c.(529-531)CCT>TCT	p.P177S		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	177						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		AGTCCCTCAGGAATCTTGCCC	0.488000													9	45					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57868608	57868608	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:57868608C>T	uc010ygw.1	+	3	1759	c.1371C>T	c.(1369-1371)GGC>GGT	p.G457G	ZNF304_uc010etw.2_Silent_p.G504G|ZNF304_uc010etx.2_Silent_p.G415G	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		AGGCCTTTGGCTGCAAAGACA	0.478000													33	113					0	0	1	0	0
ZNF419	79744	broad.mit.edu	37	19	58005429	58005429	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58005429C>T	uc002qov.2	+	5	1744	c.1504C>T	c.(1504-1506)CGA>TGA	p.R502*	ZNF547_uc002qpm.3_Intron|ZNF419_uc010ety.1_Nonsense_Mutation_p.R503*|ZNF419_uc010etz.1_Nonsense_Mutation_p.R490*|ZNF419_uc010eua.1_Nonsense_Mutation_p.R489*|ZNF419_uc002qow.2_Nonsense_Mutation_p.R470*|ZNF419_uc010eub.1_Nonsense_Mutation_p.R457*|ZNF419_uc010euc.1_Nonsense_Mutation_p.R456*	NM_024691	NP_078967	Q96HQ0	ZN419_HUMAN	zinc finger protein 419 isoform 2	502	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0252)|Lung(386;0.171)		TTTTAAACATCGAAGGATTCA	0.428000													16	77					0	0	1	0	0
ZNF773	374928	broad.mit.edu	37	19	58016682	58016682	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58016682C>T	uc002qox.2	+	3	316	c.176C>T	c.(175-177)TCC>TTC	p.S59F	ZNF547_uc002qpm.3_Intron|ZNF773_uc002qoy.2_Missense_Mutation_p.S58F|ZNF773_uc002qoz.2_RNA	NM_198542	NP_940944	Q6PK81	ZN773_HUMAN	zinc finger protein 773	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)		CTTGCATCTTCCAAGACCCAT	0.483000													8	54					0	0	1	0	0
ZIK1	284307	broad.mit.edu	37	19	58102480	58102480	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58102480C>T	uc002qpg.2	+	4	1398	c.1301C>T	c.(1300-1302)CCT>CTT	p.P434L	ZNF547_uc002qpm.3_Intron|ZIK1_uc002qph.2_Missense_Mutation_p.P379L|ZIK1_uc002qpi.2_Missense_Mutation_p.P421L|ZIK1_uc002qpj.2_Missense_Mutation_p.P331L	NM_001010879	NP_001010879	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGAGCAAGGCCTTATGAGTGT	0.458000													11	39					0	0	1	0	0
ZNF211	10520	broad.mit.edu	37	19	58146083	58146083	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58146083C>T	uc002qpq.2	+	2	357	c.177C>T	c.(175-177)TTC>TTT	p.F59F	ZNF211_uc010yhb.1_Silent_p.F63F|ZNF211_uc002qpp.2_Silent_p.F72F|ZNF211_uc002qpr.2_Silent_p.F71F|ZNF211_uc002qps.2_Silent_p.F72F|ZNF211_uc002qpt.2_Silent_p.F71F|ZNF211_uc010yhc.1_Silent_p.F71F|ZNF211_uc010yhd.1_5'UTR|ZNF211_uc010yhe.1_5'UTR	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	59	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACCTGTACTTCGATGTGATGC	0.512000													27	104					0	0	1	0	0
ZNF256	10172	broad.mit.edu	37	19	58452839	58452839	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58452839C>T	uc002qqu.2	-	3	1572	c.1337G>A	c.(1336-1338)AGG>AAG	p.R446K	ZNF256_uc010euj.2_Missense_Mutation_p.R293K	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	446	C2H2-type 9.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GTCAAATTTCCTGCTAAATAA	0.383000													11	64					0	0	1	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565236	58565236	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58565236G>A	uc002qrc.1	+	6	1291	c.1044G>A	c.(1042-1044)AGG>AGA	p.R348R		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	348					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGCCACCGAGGAAGAAAGCCC	0.667000													8	43					0	0	1	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58596472	58596472	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58596472C>T	uc002qri.2	-	7	1422	c.1113G>A	c.(1111-1113)AGG>AGA	p.R371R	ZSCAN18_uc002qrj.3_Silent_p.R370R|ZSCAN18_uc010yhs.1_Silent_p.R235R|ZSCAN18_uc002qrh.2_Silent_p.R371R|ZSCAN18_uc010yht.1_Silent_p.R427R|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	371					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CGGGGTGCGGCCTCTTGGTTC	0.721000													9	21					0	0	1	0	0
ZNF8	7554	broad.mit.edu	37	19	58805901	58805902	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58805901_58805902CC>TT	uc002qry.1	+	4	857_858	c.727_728CC>TT	c.(727-729)CCA>TTA	p.P243L	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		TCAGGCCATTCCAATTACGGAA	0.495000													5	51					0	0	1	0	0
ZNF584	201514	broad.mit.edu	37	19	58928611	58928611	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58928611T>A	uc002qsp.2	+	4	1178	c.726T>A	c.(724-726)TTT>TTA	p.F242L	ZNF584_uc010yia.1_RNA|ZNF584_uc002qsr.2_Missense_Mutation_p.F197L|ZNF584_uc010yib.1_3'UTR	NM_173548	NP_775819	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	242	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		TAAAACCTTTTAAGTGTAGTG	0.468000													5	42					0	0	1	0	0
ZNF132	7691	broad.mit.edu	37	19	58945164	58945164	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58945164C>T	uc002qst.3	-	3	2048	c.1647G>A	c.(1645-1647)GGG>GGA	p.G549G		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	549	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		CAAAGGCTTTCCCACACTCAC	0.468000													9	71					0	0	1	0	0
ZNF132	7691	broad.mit.edu	37	19	58945792	58945792	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:58945792A>T	uc002qst.3	-	3	1420	c.1019T>A	c.(1018-1020)ATT>AAT	p.I340N		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	340	C2H2-type 5.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TCCTGAGTGAATTCTCTGATG	0.408000													11	51					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1499897	1499897	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:1499897C>T	uc002qww.2	+	12	2234	c.2143C>T	c.(2143-2145)CCC>TCC	p.P715S	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.P658S|TPO_uc002qwr.2_Missense_Mutation_p.P715S|TPO_uc002qwx.2_Missense_Mutation_p.P658S|TPO_uc010yio.1_Missense_Mutation_p.P542S|TPO_uc010yip.1_Missense_Mutation_p.P715S|TPO_uc002qwy.1_Missense_Mutation_p.P55S|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	715	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CGGCAAATTCCCCGAAGACTT	0.562000													9	28					0	0	1	0	0
MBOAT2	129642	broad.mit.edu	37	2	9002816	9002816	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:9002816G>A	uc002qzg.1	-	11	1222	c.1089C>T	c.(1087-1089)ATC>ATT	p.I363I	MBOAT2_uc010yix.1_Silent_p.I363I	NM_138799	NP_620154	Q6ZWT7	MBOA2_HUMAN	O-acyltransferase (membrane bound) domain	363					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGAACGTCTGGATAGTTGGAC	0.453000													6	55					0	0	1	0	0
NTSR2	23620	broad.mit.edu	37	2	11802338	11802338	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:11802338G>A	uc002rbq.3	-	2	727	c.653C>T	c.(652-654)CCC>CTC	p.P218L		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	218	Helical; Name=5; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	TAGTGCCAAGGGGAGCACGAA	0.647000													43	232					0	0	1	0	0
SMC6	79677	broad.mit.edu	37	2	17913100	17913100	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:17913100G>A	uc002rco.2	-	6	685	c.389C>T	c.(388-390)GCC>GTC	p.A130V	SMC6_uc010exo.2_Missense_Mutation_p.A130V|SMC6_uc002rcn.2_Missense_Mutation_p.A130V|SMC6_uc002rcp.1_Missense_Mutation_p.A156V|SMC6_uc002rcq.2_Missense_Mutation_p.A156V|SMC6_uc002rcr.1_Missense_Mutation_p.A130V	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	130					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GGCTTTAAAGGCATCATCTCC	0.358000													21	36					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113148	18113148	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:18113148C>T	uc002rcv.2	+	3	1324	c.873C>T	c.(871-873)ATC>ATT	p.I291I	KCNS3_uc002rcw.2_Silent_p.I291I	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	291	Helical; Name=Segment S4; (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TGGTCCAGATCCTACGGCTTA	0.488000													28	91					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21227188	21227188	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:21227188C>T	uc002red.2	-	28	12168	c.12040G>A	c.(12040-12042)GAT>AAT	p.D4014N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4014					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCATCTTCATCCATATCCATG	0.532000													14	35					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25464459	25464459	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:25464459C>T	uc002rgc.2	-	17	2311	c.2054G>A	c.(2053-2055)GGG>GAG	p.G685E	DNMT3A_uc002rgd.2_Missense_Mutation_p.G685E|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.G496E	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	685					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGGACGTCCCCGACGTACAT	0.627000			Mis|F|N|S		AML								21	49					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27731112	27731112	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:27731112C>T	uc002rky.2	+	16	1482	c.1416C>T	c.(1414-1416)TTC>TTT	p.F472F	GCKR_uc010ezd.2_Silent_p.F470F|GCKR_uc010ylu.1_Silent_p.F282F	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	472	SIS 2.				carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					AAGGGAACTTCATCCAGGTAT	0.478000													16	70					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31564236	31564236	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:31564236C>T	uc002rnv.1	-	33	3623	c.3544G>A	c.(3544-3546)GAT>AAT	p.D1182N		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1182					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GAGCCAACATCCATGACAATA	0.483000													7	5					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31570422	31570422	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:31570422G>A	uc002rnv.1	-	29	3321	c.3242C>T	c.(3241-3243)TCT>TTT	p.S1081F		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	1081					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	AGCGCTGACAGAGGCAGCCGT	0.582000													36	85					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33487839	33487839	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:33487839C>T	uc002ros.2	+	14	2469	c.2469C>T	c.(2467-2469)CCC>CCT	p.P823P	LTBP1_uc002rot.2_Silent_p.P497P|LTBP1_uc002rou.2_Silent_p.P497P|LTBP1_uc002rov.2_Silent_p.P444P|LTBP1_uc010ymz.1_Silent_p.P497P|LTBP1_uc010yna.1_Silent_p.P444P	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	823					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTGGTCAACCCCAGCTGTCTC	0.383000													38	36					0	0	1	0	0
C2orf61	285051	broad.mit.edu	37	2	47378648	47378648	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:47378648G>A	uc002rvs.2	-	3	275	c.148C>T	c.(148-150)CCT>TCT	p.P50S	C2orf61_uc010fbd.2_RNA|C2orf61_uc010yog.1_Missense_Mutation_p.P50S	NM_173649	NP_775920	Q8N801	CB061_HUMAN	hypothetical protein LOC285051 isoform 2	50								p.0?(2)			0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			CCAGGTATAGGAGTATCCTGT	0.363000													9	82					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48915316	48915316	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:48915316G>A	uc002rwu.3	-	11	1690	c.1620C>T	c.(1618-1620)TTC>TTT	p.F540F	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	540	Helical; Name=5; (Potential).			F -> L (in Ref. 3; AAA70231).	male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CACAAATTATGAAGAAGGCCA	0.363000									Familial_Male-Limited_Precocious_Puberty				32	87					0	0	1	0	0
GPR75	10936	broad.mit.edu	37	2	54081075	54081075	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:54081075C>T	uc002rxo.3	-	2	1090	c.819G>A	c.(817-819)AGG>AGA	p.R273R	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	273	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AATTCTGGTTCCTATACAGAG	0.547000													28	39					0	0	1	0	0
EFEMP1	2202	broad.mit.edu	37	2	56144909	56144909	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:56144909G>A	uc002rzh.2	-	4	738	c.408C>T	c.(406-408)AAC>AAT	p.N136N	EFEMP1_uc002rzi.2_Silent_p.N136N|EFEMP1_uc002rzj.2_Silent_p.N136N|EFEMP1_uc010ypc.1_Silent_p.N78N	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	136					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGATGACAAAGTTATTTCGGC	0.592000													65	85					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	68962352	68962352	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:68962352G>A	uc002seu.2	+	1	385	c.21G>A	c.(19-21)AGG>AGA	p.R7R	ARHGAP25_uc010yqk.1_Intron|ARHGAP25_uc010fdg.2_Silent_p.R7R|ARHGAP25_uc010yql.1_Silent_p.R7R	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	7					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						AATTGCCAAGGAACTGGGATT	0.443000													19	122					0	0	1	0	0
ADD2	119	broad.mit.edu	37	2	70890763	70890763	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:70890763C>T	uc002sgz.2	-	16	2440	c.1975G>A	c.(1975-1977)GAG>AAG	p.E659K	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_3'UTR|ADD2_uc002sha.2_Missense_Mutation_p.E353K|ADD2_uc002sgx.2_3'UTR	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	659					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						AGGATTTCCTCTGCCGTCTGC	0.572000													27	141					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71762423	71762423	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:71762423G>A	uc002sie.2	+	15	1755	c.1379G>A	c.(1378-1380)AGG>AAG	p.R460K	DYSF_uc010feg.2_Missense_Mutation_p.R491K|DYSF_uc010feh.2_Missense_Mutation_p.R460K|DYSF_uc002sig.3_Missense_Mutation_p.R460K|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R460K|DYSF_uc010fef.2_Missense_Mutation_p.R491K|DYSF_uc010fei.2_Missense_Mutation_p.R491K|DYSF_uc010fek.2_Missense_Mutation_p.R492K|DYSF_uc010fej.2_Missense_Mutation_p.R461K|DYSF_uc010fel.2_Missense_Mutation_p.R461K|DYSF_uc010feo.2_Missense_Mutation_p.R492K|DYSF_uc010fem.2_Missense_Mutation_p.R461K|DYSF_uc010fen.2_Missense_Mutation_p.R492K|DYSF_uc002sif.2_Missense_Mutation_p.R461K	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	460	Cytoplasmic (Potential).|C2 3.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GAAAAAATGAGGATTCGTATC	0.527000													44	103					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71909780	71909780	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:71909780C>T	uc002sie.2	+	54	6553	c.6177C>T	c.(6175-6177)TTC>TTT	p.F2059F	DYSF_uc010feg.2_Silent_p.F2090F|DYSF_uc010feh.2_Silent_p.F2066F|DYSF_uc002sig.3_Silent_p.F2045F|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.F2080F|DYSF_uc010fef.2_Silent_p.F2097F|DYSF_uc010fei.2_Silent_p.F2076F|DYSF_uc010fek.2_Silent_p.F2077F|DYSF_uc010fej.2_Silent_p.F2067F|DYSF_uc010fel.2_Silent_p.F2046F|DYSF_uc010feo.2_Silent_p.F2091F|DYSF_uc010fem.2_Silent_p.F2081F|DYSF_uc010fen.2_Silent_p.F2098F|DYSF_uc002sif.2_Silent_p.F2060F|DYSF_uc010yqy.1_Silent_p.F940F|DYSF_uc010yqz.1_Silent_p.F820F	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	2059	Helical; (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TGCTGCTGTTCCTGGCCATCT	0.483000													10	36					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74462303	74462303	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:74462303G>A	uc002sko.1	-	17	2360	c.2358C>T	c.(2356-2358)TCC>TCT	p.S786S	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Silent_p.S786S|SLC4A5_uc010ffc.1_Silent_p.S786S|SLC4A5_uc002skp.1_Intron|SLC4A5_uc002sks.1_Intron	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	786	Helical; (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						ACATCAGGATGGAGAAAACAA	0.537000													24	61					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74597837	74597837	+	Missense_Mutation	SNP	G	A	A	rs149526947		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:74597837G>A	uc002skx.2	-	10	1270	c.959C>T	c.(958-960)TCC>TTC	p.S320F	DCTN1_uc002skv.2_Missense_Mutation_p.S186F|DCTN1_uc002sku.2_Missense_Mutation_p.S186F|DCTN1_uc002skw.1_Missense_Mutation_p.S296F|DCTN1_uc010ffd.2_Missense_Mutation_p.S300F|DCTN1_uc002sky.2_Missense_Mutation_p.S283F	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	320	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding	p.S320F(1)		ovary(3)|skin(2)	5						CTGCTGCAGGGACTCAGCCCG	0.557000													64	162					0	0	1	0	0
REEP1	65055	broad.mit.edu	37	2	86459843	86459843	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:86459843G>A	uc002srh.3	-	6	644	c.500C>T	c.(499-501)CCC>CTC	p.P167L	REEP1_uc010ytg.1_Missense_Mutation_p.P146L|REEP1_uc010yth.1_Missense_Mutation_p.P140L|REEP1_uc010yti.1_Missense_Mutation_p.P89S	NM_022912	NP_075063	Q9H902	REEP1_HUMAN	receptor accessory protein 1 isoform 2	167					cell death|protein insertion into membrane	integral to membrane|mitochondrial membrane	olfactory receptor binding				0						GGGGCCCGAGGGAGCAGGGGC	0.652000													44	35					0	0	1	0	0
CD8A	925	broad.mit.edu	37	2	87017736	87017736	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:87017736C>T	uc002srt.2	-	2	1007	c.118G>A	c.(118-120)GAG>AAG	p.E40K	RMND5A_uc002srs.3_Intron|CD8A_uc002srv.2_Missense_Mutation_p.E40K|CD8A_uc010ytn.1_Missense_Mutation_p.E81K|CD8A_uc002sru.2_Missense_Mutation_p.E40K	NM_001768	NP_001759	P01732	CD8A_HUMAN	CD8 antigen alpha polypeptide isoform 1	40	Ig-like V-type.|Extracellular (Potential).				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			ovary(1)	1						CACTTCAGCTCCACTGTCTCG	0.701000													33	49					0	0	1	0	0
Unknown	0	broad.mit.edu	37	2	89476119	89476119	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:89476119G>A	uc010ytr.1	-	28		c.3362C>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		ATCCCCACTGGATCCTGAAAT	0.418000													27	57					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98750402	98750402	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:98750402G>A	uc002syo.2	+	7	1252	c.988G>A	c.(988-990)GGA>AGA	p.G330R	VWA3B_uc010yvh.1_Missense_Mutation_p.G180R|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_Intron|VWA3B_uc002sym.2_Missense_Mutation_p.G330R|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	330										ovary(3)|large_intestine(2)|skin(1)	6						ACTCCCTCCAGGTACCTGGAA	0.458000													15	57					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102804374	102804374	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:102804374C>T	uc002tbs.2	+	2	173	c.47C>T	c.(46-48)TCT>TTT	p.S16F	IL1RL2_uc002tbt.2_Silent_p.L43L	NM_003854	NP_003845	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2 precursor	16					cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			ovary(2)	2						CTTCCACTGTCTGTCACAGCA	0.642000													16	129					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103121890	103121890	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:103121890C>T	uc002tbz.3	+	4	1615	c.1158C>T	c.(1156-1158)ATC>ATT	p.I386I		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	386	Helical; Name=K/M9; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GGGCCTTCATCTGCTTCACCC	0.527000													12	96					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108475848	108475848	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:108475848G>A	uc010ywk.1	+	11	1554	c.1472G>A	c.(1471-1473)GGA>GAA	p.G491E	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	491					intracellular transport		binding			skin(2)	2						TTTCTCCTTGGAGTAGTATAT	0.318000													38	45					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108614302	108614302	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:108614302A>T	uc002tdv.2	+	5	733	c.457A>T	c.(457-459)ATC>TTC	p.I153F	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.I153F|SLC5A7_uc010ywn.1_Missense_Mutation_p.I40F	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	153	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	AGGAGCCACCATCAGCGTGAT	0.453000													118	198					0	0	1	0	0
SULT1C3	442038	broad.mit.edu	37	2	108881765	108881765	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:108881765G>A	uc010ywo.1	+	7	873	c.873G>A	c.(871-873)AAG>AAA	p.K291K		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	291						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						ACTACCAGAAGAAGATGGCAG	0.453000													10	66					0	0	1	0	0
IL1F8	27177	broad.mit.edu	37	2	113786542	113786542	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:113786542G>A	uc002tiq.1	-	4	339	c.235C>T	c.(235-237)CAG>TAG	p.Q79*	IL1F8_uc002tir.1_Nonsense_Mutation_p.Q79*	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	79					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						GGCTTGCCCTGAATTTCTGCA	0.398000													41	62					0	0	1	0	0
TFCP2L1	29842	broad.mit.edu	37	2	122005828	122005828	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:122005828C>T	uc002tmx.2	-	5	509	c.416G>A	c.(415-417)GGT>GAT	p.G139D	TFCP2L1_uc010flr.2_Missense_Mutation_p.G139D	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	139					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GTCCAAGATACCAACAGACAG	0.488000													18	43					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125521373	125521373	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:125521373G>A	uc002tno.2	+	15	2720	c.2356G>A	c.(2356-2358)GAC>AAC	p.D786N	CNTNAP5_uc010flu.2_Missense_Mutation_p.D787N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	786	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TTGCTATGGTGACCGTGAGTA	0.458000													8	8					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125671812	125671812	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:125671812G>A	uc002tno.2	+	24	4232	c.3868G>A	c.(3868-3870)GAA>AAA	p.E1290K	CNTNAP5_uc010flu.2_Missense_Mutation_p.E1291K	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1290	Cytoplasmic (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CTTCAGAAATGAAATTGACTT	0.418000													5	25					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128327434	128327434	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:128327434C>T	uc002top.2	+	6	594	c.541C>T	c.(541-543)CAG>TAG	p.Q181*		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	181	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CATCAGTGGCCAGCATTCGTG	0.627000													22	20					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814118	137814118	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:137814118G>A	uc002tva.1	+	2	175	c.175G>A	c.(175-177)GAA>AAA	p.E59K	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_5'UTR	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GCCTCCAAAGGAAAGAAGTTG	0.537000													13	30					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	137814349	137814349	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:137814349C>T	uc002tva.1	+	2	406	c.406C>T	c.(406-408)CCT>TCT	p.P136S	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.P26S	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTTCAGCCTCCTACAGAACA	0.507000													86	124					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141072507	141072507	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:141072507G>A	uc002tvj.1	-	83	13774	c.12802C>T	c.(12802-12804)CTA>TTA	p.L4268L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4268	Extracellular (Potential).|EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TATTTACCTAGAACTGATGGT	0.353000										TSP Lung(27;0.18)			10	25					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141083389	141083389	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:141083389G>A	uc002tvj.1	-	80	13254	c.12282C>T	c.(12280-12282)ATC>ATT	p.I4094I		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4094	Extracellular (Potential).|LDL-receptor class B 36.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACTGCCAATGATGGAGAGCT	0.383000										TSP Lung(27;0.18)			13	28					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141660651	141660651	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:141660651C>T	uc002tvj.1	-	23	4576	c.3604G>A	c.(3604-3606)GGA>AGA	p.G1202R	LRP1B_uc010fnl.1_Missense_Mutation_p.G384R	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1202	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTTGAAGTCCTTCAGGGCAG	0.428000										TSP Lung(27;0.18)			22	27					0	0	1	0	0
KCNJ3	3760	broad.mit.edu	37	2	155566141	155566141	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:155566141C>T	uc002tyv.1	+	2	924	c.729C>T	c.(727-729)TTC>TTT	p.F243F	KCNJ3_uc010zce.1_Intron	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	243	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AGGGTGAGTTCCTTCCCCTTG	0.458000													26	36					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158287454	158287454	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:158287454C>T	uc002tzj.1	-	4	372	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q	CYTIP_uc010zcl.1_5'UTR	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	100	PDZ.				regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						AGCAGGCATTCTGATTCTGGG	0.373000													16	24					0	0	1	0	0
TANC1	85461	broad.mit.edu	37	2	160027078	160027078	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:160027078C>T	uc002uag.2	+	10	1387	c.1113C>T	c.(1111-1113)CCC>CCT	p.P371P	TANC1_uc010fol.1_Silent_p.P265P|TANC1_uc010zcm.1_Silent_p.P363P|TANC1_uc010fom.1_Silent_p.P177P	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	371						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TGTTGAAACCCTTGTTGTTTG	0.353000													10	108					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163241233	163241233	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:163241233C>T	uc002uch.1	-	13	3139	c.2927G>A	c.(2926-2928)AGA>AAA	p.R976K		NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	976	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TATGTGCATTCTTCCTGAGGT	0.428000													21	51					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166243485	166243485	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:166243485G>A	uc002udc.2	+	26	5071	c.4781G>A	c.(4780-4782)TGG>TAG	p.W1594*	SCN2A_uc002udd.2_Nonsense_Mutation_p.W1594*|SCN2A_uc002ude.2_Nonsense_Mutation_p.W1594*	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1594	Helical; Name=S3 of repeat IV; (Potential).|IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ACTATTGGATGGAATATTTTT	0.333000													20	55					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167162417	167162417	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:167162417C>T	uc010fpl.2	-	5	822	c.481G>A	c.(481-483)GGA>AGA	p.G161R	SCN9A_uc002udr.1_Missense_Mutation_p.G32R|SCN9A_uc002uds.1_Missense_Mutation_p.G32R|SCN9A_uc002udt.1_Missense_Mutation_p.G32R	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	161	I.|Helical; Name=S2 of repeat I; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GTATATATTCCAGTAAAAGTG	0.348000													11	26					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100393	168100393	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:168100393G>A	uc002udx.2	+	8	2509	c.2491G>A	c.(2491-2493)GAA>AAA	p.E831K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.E656K|XIRP2_uc010fpq.2_Missense_Mutation_p.E609K|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	656					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CATTGAAAAGGAAAAAATAAT	0.388000													43	52					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169791714	169791714	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:169791714G>A	uc002ueo.1	-	23	3162	c.3036C>T	c.(3034-3036)CTC>CTT	p.L1012L	ABCB11_uc010zda.1_Silent_p.L454L|ABCB11_uc010zdb.1_Silent_p.L488L	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1012	Helical; (Potential).|ABC transmembrane type-1 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	AGCTGAAATGGAGCCCCTCAT	0.393000													46	113					0	0	1	0	0
OSBPL6	114880	broad.mit.edu	37	2	179226427	179226427	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179226427C>T	uc002ulx.2	+	13	1550	c.1172C>T	c.(1171-1173)TCT>TTT	p.S391F	OSBPL6_uc002ulw.2_Missense_Mutation_p.S360F|OSBPL6_uc002uly.2_Missense_Mutation_p.S416F|OSBPL6_uc010zfe.1_Missense_Mutation_p.S360F|OSBPL6_uc002ulz.2_Missense_Mutation_p.S391F|OSBPL6_uc002uma.2_Missense_Mutation_p.S395F	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	391					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CTTTTGAAGTCTGCATTTAAT	0.433000													27	77					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179423233	179423233	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179423233C>T	uc010zfg.1	-	276	79473	c.79249G>A	c.(79249-79251)GGA>AGA	p.G26417R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G20112R|TTN_uc010zfi.1_Missense_Mutation_p.G20045R|TTN_uc010zfj.1_Missense_Mutation_p.G19920R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27344							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTCTGTCCTTTTTCTAGT	0.433000													10	20					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179444921	179444921	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179444921C>T	uc010zfg.1	-	267	59613	c.59389G>A	c.(59389-59391)GAA>AAA	p.E19797K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E13492K|TTN_uc010zfi.1_Missense_Mutation_p.E13425K|TTN_uc010zfj.1_Missense_Mutation_p.E13300K|uc002umv.1_3'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20724							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGGATATTTCCTTAACAGTC	0.373000													12	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179570033	179570033	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179570033C>T	uc010zfg.1	-	100	25964	c.25740G>A	c.(25738-25740)ATG>ATA	p.M8580I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.M5241I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9507							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGAAGTTCCATGATATCAA	0.343000													5	10					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179583614	179583614	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179583614G>T	uc010zfg.1	-	81	20805	c.20581C>A	c.(20581-20583)CCT>ACT	p.P6861T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P3522T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7788							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGAAAGGAGGGGTGCCTCTG	0.473000													8	18					1.76689e-08	1.78087e-08	1	1	0
TTN	7273	broad.mit.edu	37	2	179585804	179585804	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179585804C>T	uc010zfg.1	-	76	19434	c.19210G>A	c.(19210-19212)GAA>AAA	p.E6404K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E3065K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7331							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATGAAGTTCGCTGTCATTT	0.403000													13	56					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587872	179587872	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179587872C>T	uc010zfg.1	-	72	18354	c.18130G>A	c.(18130-18132)GAA>AAA	p.E6044K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E2705K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6971							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGAATTTCCAGGATACAA	0.393000													7	18					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179597238	179597238	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179597238G>A	uc010zfg.1	-	53	13042	c.12818C>T	c.(12817-12819)TCG>TTG	p.S4273L	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S934L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5200							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTACGTGCCCGAATCAGAGGT	0.418000													17	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613716	179613716	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179613716C>T	uc002unb.2	-	46	13635	c.13411G>A	c.(13411-13413)GGA>AGA	p.G4471R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTAGAACTCCTTTTTCTACA	0.348000													5	15					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179710428	179710428	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:179710428G>A	uc002unf.1	-	12	1731	c.1674C>T	c.(1672-1674)TTC>TTT	p.F558F	CCDC141_uc002une.1_Silent_p.F8F	NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	558							protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			AATCATAATGGAAGTCTTCCA	0.373000													11	16					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182374525	182374525	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:182374525G>A	uc002unu.2	+	16	2599	c.1836G>A	c.(1834-1836)ATG>ATA	p.M612I	ITGA4_uc010frj.1_Missense_Mutation_p.M94I	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	612	SG1.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AAGACATAATGAAAAAAACAG	0.328000													8	29					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185798364	185798364	+	Missense_Mutation	SNP	G	A	A	rs145158210		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:185798364G>A	uc002uph.2	+	3	884	c.290G>A	c.(289-291)CGA>CAA	p.R97Q		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	97						intracellular	zinc ion binding	p.R97Q(1)		ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAATTTGCTCGAAATGTAGCA	0.368000													8	34					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802855	185802855	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:185802855C>T	uc002uph.2	+	4	3326	c.2732C>T	c.(2731-2733)TCC>TTC	p.S911F		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	911						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TCAGATGTTTCCAATGATCCC	0.403000													37	42					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187693001	187693001	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:187693001G>A	uc002upu.1	-	9	1652	c.1612C>T	c.(1612-1614)CAC>TAC	p.H538Y		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	538					apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			AGACTAGTGTGAAATTTTCCA	0.398000													14	28					0	0	1	0	0
HECW2	57520	broad.mit.edu	37	2	197184479	197184479	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:197184479C>T	uc002utm.1	-	9	1318	c.1135G>A	c.(1135-1137)GAT>AAT	p.D379N	HECW2_uc002utl.1_Missense_Mutation_p.D23N	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	379					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGGGTTCCATCGGCAGCACTG	0.542000													10	110					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198267484	198267484	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:198267484G>A	uc002uue.2	-	14	1921	c.1873C>T	c.(1873-1875)CGT>TGT	p.R625C		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	625	HEAT 3.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			GTTGTGTTACGGACATACTCA	0.433000													11	45					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201434420	201434420	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:201434420G>A	uc002uvw.2	+	6	621	c.508G>A	c.(508-510)GAT>AAT	p.D170N	SGOL2_uc002uvv.3_Missense_Mutation_p.D170N|SGOL2_uc010zhd.1_Missense_Mutation_p.D170N|SGOL2_uc010zhe.1_Missense_Mutation_p.D170N	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	170					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						TGAAGATGAAGATAAAGAGAA	0.328000													21	27					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207175137	207175137	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:207175137G>A	uc002vbp.2	+	5	6135	c.5885G>A	c.(5884-5886)AGA>AAA	p.R1962K		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1962							nucleic acid binding|zinc ion binding			ovary(3)	3						AAAATAATTAGACAAGAGGAA	0.398000													16	28					0	0	1	0	0
IKZF2	22807	broad.mit.edu	37	2	213872264	213872264	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:213872264C>T	uc002vem.2	-	8	1570	c.1401G>A	c.(1399-1401)CAG>CAA	p.Q467Q	IKZF2_uc010fuu.2_Silent_p.Q322Q|IKZF2_uc002vej.2_Silent_p.Q414Q|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Silent_p.Q393Q|IKZF2_uc002vel.2_Silent_p.Q388Q|IKZF2_uc010fuw.2_Silent_p.Q241Q|IKZF2_uc010fux.2_Silent_p.Q241Q|IKZF2_uc010fuy.2_Silent_p.Q395Q|IKZF2_uc002ven.2_Silent_p.Q441Q|IKZF2_uc002vei.2_Silent_p.Q245Q	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	467					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		AGGCCCTAATCTGTTCTCCTT	0.493000													22	92					0	0	1	0	0
VWC2L	402117	broad.mit.edu	37	2	215278963	215278963	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:215278963C>T	uc002vet.2	+	2	176	c.46C>T	c.(46-48)CCT>TCT	p.P16S	VWC2L_uc010zjl.1_Missense_Mutation_p.P16S	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	16						extracellular region					0						GTTGGTCATCCCTGGATTGGT	0.433000													14	43					0	0	1	0	0
CYP27A1	1593	broad.mit.edu	37	2	219677362	219677362	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:219677362G>A	uc002viz.3	+	4	1168	c.734G>A	c.(733-735)GGG>GAG	p.G245E		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	245					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	AGATCCATCGGGTTAATGTTC	0.547000													254	378					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219903680	219903680	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:219903680G>A	uc002vjl.1	-	3	175	c.91C>T	c.(91-93)CCT>TCT	p.P31S	CCDC108_uc010zkp.1_Intron|CCDC108_uc010zkq.1_Intron|CCDC108_uc002vjn.2_Intron	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	31						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGAGAAGAGGAATAAGGGGG	0.443000													33	90					0	0	1	0	0
C2orf24	27013	broad.mit.edu	37	2	220037365	220037365	+	Silent	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:220037365A>G	uc002vju.3	-	8	1328	c.1176T>C	c.(1174-1176)TGT>TGC	p.C392C	NHEJ1_uc002vjq.3_5'Flank|SLC23A3_uc010zkr.1_5'Flank|SLC23A3_uc010zks.1_5'Flank|SLC23A3_uc010fwb.2_5'Flank|C2orf24_uc002vjv.2_Silent_p.C392C	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	392					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGAAAAGGGAACATTGCTGAG	0.572000													25	116					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222347181	222347181	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:222347181G>A	uc002vmq.2	-	5	1251	c.1209C>T	c.(1207-1209)CTC>CTT	p.L403L	EPHA4_uc002vmr.2_Silent_p.L403L|EPHA4_uc010zlm.1_Silent_p.L344L|EPHA4_uc010zln.1_Silent_p.L403L	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	403	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TATGAGCTAGGAGGTCAGTGA	0.512000													97	241					0	0	1	0	0
MOGAT1	116255	broad.mit.edu	37	2	223559157	223559157	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:223559157C>T	uc010fws.1	+	4	603	c.555C>T	c.(553-555)GTC>GTT	p.V185V	MOGAT1_uc010fwt.1_Silent_p.V145V	NM_058165	NP_477513	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	185					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		CTGTCATTGTCCTTGGGGGTG	0.438000													5	40					0	0	1	0	0
KIAA1486	57624	broad.mit.edu	37	2	226447249	226447249	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:226447249G>A	uc002voe.2	+	4	1291	c.1116G>A	c.(1114-1116)ATG>ATA	p.M372I	KIAA1486_uc010fxa.1_Intron|KIAA1486_uc002vof.1_Missense_Mutation_p.M142I	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	372	Pro-rich.									ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		TGTCTTACATGAAACAGCCAG	0.667000													14	20					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227924301	227924301	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:227924301C>T	uc010zlt.1	-	28	2857	c.2203G>A	c.(2203-2205)GAA>AAA	p.E735K		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	735	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GACCCCTTTTCACCTCCAAAA	0.483000													39	68					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882663	228882663	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:228882663C>T	uc002vpq.2	-	7	2954	c.2907G>A	c.(2905-2907)CTG>CTA	p.L969L	SPHKAP_uc002vpp.2_Silent_p.L969L|SPHKAP_uc010zlx.1_Silent_p.L969L	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	969						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGGGTGTCATCAGAAACTCAC	0.537000													36	66					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884687	228884687	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:228884687C>T	uc002vpq.2	-	7	930	c.883G>A	c.(883-885)GCC>ACC	p.A295T	SPHKAP_uc002vpp.2_Missense_Mutation_p.A295T|SPHKAP_uc010zlx.1_Missense_Mutation_p.A295T	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	295						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCTGCAAGGCTGTGTTCTTT	0.418000													38	217					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890376	229890376	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:229890376G>A	uc002vpr.3	-	3	763	c.725C>T	c.(724-726)TCC>TTC	p.S242F	PID1_uc002vps.3_Missense_Mutation_p.S240F|PID1_uc002vpt.3_Missense_Mutation_p.S209F|PID1_uc002vpu.3_Missense_Mutation_p.S160F	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	242	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		CAATTCCTGGGAAACCTCTTC	0.512000													34	83					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231101813	231101813	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:231101813C>T	uc002vql.2	+	2	190	c.75C>T	c.(73-75)ATC>ATT	p.I25I	SP140_uc010zma.1_RNA|SP140_uc002vqj.2_Silent_p.I25I|SP140_uc002vqk.2_Silent_p.I25I|SP140_uc002vqn.2_Silent_p.I25I|SP140_uc002vqm.2_Silent_p.I25I|SP140_uc010fxl.2_Silent_p.I25I	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	25	HSR.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCGCAGAGATCCAGAACGTAG	0.408000													8	24					0	0	1	0	0
CAB39	51719	broad.mit.edu	37	2	231663609	231663609	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:231663609C>T	uc002vqx.2	+	5	996	c.564C>T	c.(562-564)TTC>TTT	p.F188F	CAB39_uc010fxr.2_Silent_p.F188F|CAB39_uc010fxq.2_Silent_p.F188F	NM_016289	NP_057373	Q9Y376	CAB39_HUMAN	calcium binding protein 39	188					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	kinase binding			central_nervous_system(1)	1		all_lung(227;4.63e-07)|all_hematologic(139;1.83e-06)|Lung NSC(271;2.11e-05)|Acute lymphoblastic leukemia(138;5.51e-05)|Hepatocellular(293;0.0207)|Lung SC(224;0.187)		all cancers(144;1.64e-12)|Epithelial(121;5.29e-11)|LUSC - Lung squamous cell carcinoma(224;0.0154)|Lung(119;0.0177)|COAD - Colon adenocarcinoma(134;0.226)		TTGCCACATTCAAGGTAACAA	0.378000													4	13					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238245121	238245121	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:238245121C>T	uc002vwl.2	-	40	8907	c.8622G>A	c.(8620-8622)ACG>ACA	p.T2874T	COL6A3_uc002vwo.2_Silent_p.T2668T|COL6A3_uc010znj.1_Silent_p.T2267T|COL6A3_uc002vwj.2_Silent_p.T255T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2874	Nonhelical region.|Thr-rich.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TCACCGGCTTCGTTGTCGTCA	0.433000													84	131					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239039092	239039092	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:239039092C>T	uc002vxq.3	+	9	1847	c.1737C>T	c.(1735-1737)GCC>GCT	p.A579A	ESPNL_uc010fyw.2_Silent_p.A275A	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	579										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CTGCGGAGGCCTCAGAGGTGG	0.697000													9	10					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241976319	241976319	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr2:241976319G>A	uc002wah.1	+	5	918	c.918G>A	c.(916-918)CGG>CGA	p.R306R		NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	306	EGF-like 1.				cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		TCACGGGGCGGAGGTGCCACC	0.716000													3	13					0	0	1	0	0
PDYN	5173	broad.mit.edu	37	20	1961379	1961379	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:1961379C>T	uc010gaj.2	-	3	597	c.355G>A	c.(355-357)GAG>AAG	p.E119K	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.E119K|PDYN_uc010zpt.1_Intron	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	119					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						AGAGTGTTCTCCTTTGTTGAG	0.552000													18	84					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2378579	2378579	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:2378579C>T	uc002wfy.1	+	5	620	c.559C>T	c.(559-561)CTG>TTG	p.L187L	TGM6_uc010gal.1_Silent_p.L187L	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	187					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GGAGGACATCCTGAACATCTG	0.602000													24	69					0	0	1	0	0
C20orf141	128653	broad.mit.edu	37	20	2795836	2795836	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:2795836C>T	uc010gat.2	+	2	89	c.6C>T	c.(4-6)ACC>ACT	p.T2T	C20orf141_uc002wgv.1_Silent_p.T2T|C20orf141_uc002wgw.2_Silent_p.T2T|uc002wgx.1_5'Flank|uc002wgy.1_5'Flank	NM_080739	NP_542777	Q9NUB4	CT141_HUMAN	hypothetical protein LOC128653	2						integral to membrane					0						TCTCCATGACCCGGCTCTGCT	0.612000													32	158					0	0	1	0	0
ATRN	8455	broad.mit.edu	37	20	3520922	3520922	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:3520922G>A	uc002wim.2	+	3	638	c.548G>A	c.(547-549)TGG>TAG	p.W183*	ATRN_uc002wil.2_Nonsense_Mutation_p.W183*	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	183	Extracellular (Potential).|CUB.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						GAGTGTAGTTGGGACCATTTA	0.328000													58	210					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4228549	4228549	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:4228549G>A	uc002wkr.2	-	1	1111	c.1056C>T	c.(1054-1056)ATC>ATT	p.I352I		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	352	Helical; Name=6; (By similarity).				cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	CACCCACGACGATGGCCAGAG	0.637000													4	16					0	0	1	0	0
ANKRD5	63926	broad.mit.edu	37	20	10030780	10030780	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:10030780G>A	uc002wno.2	+	7	1956	c.1563G>A	c.(1561-1563)AAG>AAA	p.K521K	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Silent_p.K521K|ANKRD5_uc010gbz.2_Silent_p.K332K	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	521							calcium ion binding			ovary(1)|breast(1)	2						TGGATATGAAGGATAATTATT	0.413000													8	32					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20232362	20232362	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:20232362C>T	uc002wru.2	+	20	2359	c.2283C>T	c.(2281-2283)ATC>ATT	p.I761I	C20orf26_uc010zse.1_Silent_p.I741I|C20orf26_uc002wrw.2_RNA|C20orf26_uc002wrv.2_Silent_p.I117I	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	761										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CGGACGAGATCGTGCCCTACG	0.597000													25	104					0	0	1	0	0
CST9L	128821	broad.mit.edu	37	20	23545595	23545595	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:23545595C>T	uc002wtk.3	-	3	733	c.434G>A	c.(433-435)GGA>GAA	p.G145E		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	145						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					TCAGTGGAATCCCTCCAAGCA	0.537000													30	103					0	0	1	0	0
BPIL1	80341	broad.mit.edu	37	20	31607401	31607401	+	Missense_Mutation	SNP	C	T	T	rs150536106		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:31607401C>T	uc002wyj.2	+	11	1119	c.925C>T	c.(925-927)CCC>TCC	p.P309S		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	309						extracellular region	lipid binding	p.P309S(1)		skin(2)|large_intestine(1)|ovary(1)	4						CCGCCAGTTTCCCGAGCCCAT	0.667000													7	36					0	0	1	0	0
C20orf185	359710	broad.mit.edu	37	20	31652477	31652477	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:31652477C>T	uc002wym.1	+	8	750	c.750C>T	c.(748-750)ATC>ATT	p.I250I		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	250					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						TGCAGCCTATCGTGAAGAGTG	0.607000													9	79					0	0	1	0	0
PLUNC	51297	broad.mit.edu	37	20	31828181	31828181	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:31828181C>T	uc002wyv.2	+	5	641	c.571C>T	c.(571-573)CTG>TTG	p.L191L	PLUNC_uc002wyt.3_Silent_p.L191L|PLUNC_uc002wyu.3_Silent_p.L191L	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	191					innate immune response	extracellular region	lipid binding				0						GCAAATTTCTCTGCTTGATGG	0.517000													39	183					0	0	1	0	0
CBFA2T2	9139	broad.mit.edu	37	20	32217568	32217568	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:32217568C>T	uc002wzg.1	+	9	1640	c.1103C>T	c.(1102-1104)TCT>TTT	p.S368F	CBFA2T2_uc010zug.1_Missense_Mutation_p.S142F|CBFA2T2_uc002wze.1_Missense_Mutation_p.S359F|CBFA2T2_uc002wzf.1_RNA|CBFA2T2_uc002wzh.1_Missense_Mutation_p.S339F|CBFA2T2_uc002wzi.1_RNA|CBFA2T2_uc002wzj.1_RNA	NM_005093	NP_005084	O43439	MTG8R_HUMAN	core-binding factor, runt domain, alpha subunit	368						nucleus	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)|skin(1)	2						ACAAGGCGCTCTATGGCAGTT	0.483000													29	104					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33329490	33329491	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:33329490_33329491CC>TT	uc002xav.2	-	12	7140_7141	c.4569_4570GG>AA	c.(4567-4572)GAGGAC>GAAAAC	p.D1524N	NCOA6_uc002xaw.2_Missense_Mutation_p.D1524N	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1524					brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TTTTTGAGGTCCTCCCCAGAAA	0.446000													9	56					0	0	1	0	0
PHF20	51230	broad.mit.edu	37	20	34430609	34430609	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:34430609C>T	uc002xek.1	+	3	309	c.198C>T	c.(196-198)CGC>CGT	p.R66R	PHF20_uc002xei.1_Silent_p.R66R|PHF20_uc010gfo.1_Silent_p.R66R|PHF20_uc002xej.1_5'UTR|PHF20_uc002xel.1_5'UTR	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	66					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CTTATTTACGCCCTTTAGAGA	0.438000													8	49					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34783264	34783264	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:34783264C>T	uc002xfb.2	+	13	1634	c.1463C>T	c.(1462-1464)ACC>ATC	p.T488I	EPB41L1_uc002xeu.2_Intron|EPB41L1_uc010zvo.1_Missense_Mutation_p.T488I|EPB41L1_uc002xev.2_Missense_Mutation_p.T488I|EPB41L1_uc002xew.2_Intron|EPB41L1_uc002xex.2_Intron|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Intron|EPB41L1_uc010gfq.2_5'Flank	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	488	Spectrin--actin-binding.				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					GAGCAGGAAACCACGCCGAGA	0.567000													14	76					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35075257	35075257	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:35075257C>T	uc002xff.2	+	7	2000	c.1565C>T	c.(1564-1566)TCG>TTG	p.S522L	DLGAP4_uc010zvp.1_Missense_Mutation_p.S522L	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	522					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GCAGGCTGCTCGCAGGAGGAG	0.637000													6	25					0	0	1	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36386000	36386000	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:36386000C>G	uc010zvw.1	+	6	597	c.506C>G	c.(505-507)ACA>AGA	p.T169R	CTNNBL1_uc002xhh.2_Intron|CTNNBL1_uc002xhi.2_RNA	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	169					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				CAGGAATTAACAGATATAGAC	0.418000													8	50					0	0	1	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37547025	37547025	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:37547025G>A	uc002xje.2	+	11	1609	c.1420G>A	c.(1420-1422)GAA>AAA	p.E474K	PPP1R16B_uc010ggc.2_Missense_Mutation_p.E432K	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	474					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CAGCTACAAGGAACAGAGCCC	0.642000													13	87					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37631466	37631466	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:37631466C>T	uc002xjh.2	+	10	818	c.807C>T	c.(805-807)CAC>CAT	p.H269H	DHX35_uc010zwa.1_Silent_p.H114H|DHX35_uc010zwb.1_Silent_p.H114H|DHX35_uc010zwc.1_Silent_p.H238H	NM_021931	NP_068750	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	269	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			lung(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TGAAAATTCACCAGACAGAGG	0.388000													17	84					0	0	1	0	0
PLCG1	5335	broad.mit.edu	37	20	39801100	39801100	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:39801100C>T	uc002xjp.1	+	26	3066	c.2945C>T	c.(2944-2946)TCC>TTC	p.S982F	PLCG1_uc002xjo.1_Missense_Mutation_p.S982F|PLCG1_uc010zwe.1_Missense_Mutation_p.S608F	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	982	PI-PLC Y-box.				activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GACATGTCATCCTTCCCGGAA	0.547000													16	46					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40747137	40747137	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:40747137G>A	uc002xkg.2	-	21	3072	c.2888C>T	c.(2887-2889)CCG>CTG	p.P963L	PTPRT_uc010ggj.2_Missense_Mutation_p.P982L|PTPRT_uc010ggi.2_Missense_Mutation_p.P166L	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	963	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTCCTGCATCGGACCTGCCAA	0.532000													19	72					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40827881	40827881	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:40827881G>A	uc002xkg.2	-	16	2674	c.2490C>T	c.(2488-2490)TTC>TTT	p.F830F	PTPRT_uc010ggj.2_Silent_p.F849F|PTPRT_uc010ggi.2_Silent_p.F33F	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	830	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCTACTTACTGAATCCGTTGA	0.562000													120	570					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41076902	41076902	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:41076902C>T	uc002xkg.2	-	9	1702	c.1518G>A	c.(1516-1518)TGG>TGA	p.W506*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.W506*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	506	Extracellular (Potential).|Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGGAGGTTTCCACTGGATGT	0.483000													34	130					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41419882	41419882	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:41419882C>T	uc002xkg.2	-	3	623	c.439G>A	c.(439-441)GTG>ATG	p.V147M	PTPRT_uc010ggj.2_Missense_Mutation_p.V147M	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	147	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCTGCCTTCACCCAGCCCTCA	0.498000													22	145					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41419972	41419972	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:41419972G>A	uc002xkg.2	-	3	533	c.349C>T	c.(349-351)CCA>TCA	p.P117S	PTPRT_uc010ggj.2_Missense_Mutation_p.P117S	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	117	Extracellular (Potential).|MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AAGGCCCCTGGGCTGGACCTG	0.592000													17	68					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42694565	42694565	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:42694565C>T	uc002xlf.3	+	6	1137	c.1120C>T	c.(1120-1122)CCG>TCG	p.P374S	TOX2_uc010ggo.2_Missense_Mutation_p.P392S|TOX2_uc002xle.3_Missense_Mutation_p.P350S|TOX2_uc010ggp.2_Missense_Mutation_p.P350S|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Missense_Mutation_p.P270S	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	374	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GTCCCCGCCGCCGCCACCCTC	0.716000													12	56					0	0	1	0	0
CTSA	5476	broad.mit.edu	37	20	44521930	44521931	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:44521930_44521931CC>TT	uc002xqj.3	+	7	1146_1147	c.672_673CC>TT	c.(670-675)TACCAT>TATTAT	p.H225Y	NEURL2_uc002xqg.1_5'Flank|CTSA_uc002xqh.2_Missense_Mutation_p.H243Y|CTSA_uc002xqi.2_RNA|CTSA_uc010zxi.1_Missense_Mutation_p.H226Y|CTSA_uc002xqk.3_Missense_Mutation_p.H225Y	NM_001127695	NP_001121167	P10619	PPGB_HUMAN	cathepsin A isoform b precursor	225					intracellular protein transport|proteolysis	endoplasmic reticulum|lysosome|nucleus	enzyme activator activity|protein binding|serine-type carboxypeptidase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TTGCCTACTACCATGGCCTTCT	0.550000													11	98					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49218838	49218838	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:49218838C>T	uc002xvm.2	-	13	1736	c.1418G>A	c.(1417-1419)GGA>GAA	p.G473E	FAM65C_uc010zyt.1_Missense_Mutation_p.G477E|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.G473E	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	473										ovary(2)	2						GCTCTCCCCTCCTAAGTTCCT	0.677000													4	37					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872321	51872321	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:51872321C>T	uc002xwo.2	+	2	3280	c.2324C>T	c.(2323-2325)GCC>GTC	p.A775V		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	775					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			AGCAAGAAAGCCGAGTCCTCG	0.557000													25	103					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645041	52645041	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:52645041C>T	uc002xws.2	-	4	951	c.613G>A	c.(613-615)GAA>AAA	p.E205K	BCAS1_uc010zzb.1_Missense_Mutation_p.E108K|BCAS1_uc010gim.2_Missense_Mutation_p.E108K|BCAS1_uc002xwt.2_Missense_Mutation_p.E205K|BCAS1_uc010gil.1_Missense_Mutation_p.E205K|BCAS1_uc010zzc.1_Missense_Mutation_p.E108K	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	205						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			GGCACCTTTTCCTGTCCCTTG	0.552000													38	192					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60498607	60498607	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:60498607G>A	uc002ybn.1	+	10	1487	c.1473G>A	c.(1471-1473)ACG>ACA	p.T491T	CDH4_uc002ybp.1_Silent_p.T417T	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	491	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			TCCAGTCCACGGCAGGGGTGA	0.612000													11	50					0	0	1	0	0
C20orf151	140893	broad.mit.edu	37	20	60988583	60988583	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:60988583G>A	uc002ycw.1	-	11	1706	c.1549C>T	c.(1549-1551)CCA>TCA	p.P517S		NM_080833	NP_543023	Q8NC74	CT151_HUMAN	hypothetical protein LOC140893	517	Pro-rich.										0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;6.43e-06)			TGGGACCCTGGAAGTGGGCGT	0.637000													13	46					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61468540	61468540	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr20:61468540C>T	uc002ydm.2	+	30	1712	c.1709C>T	c.(1708-1710)TCC>TTC	p.S570F	COL9A3_uc002ydn.2_Missense_Mutation_p.S64F	NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	570	Triple-helical region 2 (COL2).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					CCCCCAGGCTCCATTGGTCAC	0.682000													20	96					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15745972	15745972	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:15745972G>A	uc002yjt.2	-	5	1451	c.1382C>T	c.(1381-1383)CCC>CTC	p.P461L	HSPA13_uc011abx.1_Missense_Mutation_p.P253L	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	461						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						ATGCTTATTGGGAATTTCTAA	0.413000													7	56					0	0	1	0	0
C21orf91	54149	broad.mit.edu	37	21	19169217	19169217	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:19169217G>A	uc002yko.3	-	3	437	c.346C>T	c.(346-348)CCC>TCC	p.P116S	C21orf91_uc002ykq.3_Missense_Mutation_p.P116S|C21orf91_uc002ykp.3_Missense_Mutation_p.P116S	NM_001100420	NP_001093890	Q9NYK6	EURL_HUMAN	early undifferentiated retina and lens isoform	116										ovary(1)	1				Epithelial(23;8.76e-05)|all cancers(11;0.000422)|OV - Ovarian serous cystadenocarcinoma(11;0.0107)|Lung(58;0.0129)|COAD - Colon adenocarcinoma(22;0.0303)|LUSC - Lung squamous cell carcinoma(23;0.0381)|Colorectal(24;0.0929)		TGATGCTGGGGGTTTTTAGAA	0.353000													14	61					0	0	1	0	0
RNF160	26046	broad.mit.edu	37	21	30365209	30365209	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:30365209G>A	uc002ymr.2	-	1	69	c.56C>T	c.(55-57)TCT>TTT	p.S19F		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	Error:Variant_position_missing_in_O94822_after_alignment							ligase activity|zinc ion binding				0						GGCGGCGGAAGAGGACACCCT	0.632000													6	10					0	0	1	0	0
GART	2618	broad.mit.edu	37	21	34876803	34876803	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:34876803G>A	uc002yrx.2	-	21	2892	c.2757C>T	c.(2755-2757)CTC>CTT	p.L919L	GART_uc002yrz.2_Silent_p.L919L|GART_uc010gmd.2_Silent_p.L581L|GART_uc002yry.2_Silent_p.L919L	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	919	GART.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	TAAAAGAAGGGAGCAAGGATG	0.393000													9	70					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37618856	37618856	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:37618856C>T	uc002yvg.2	+	19	4657	c.4578C>T	c.(4576-4578)TCC>TCT	p.S1526S	DOPEY2_uc011aeb.1_Silent_p.S1475S|DOPEY2_uc002yvh.2_Silent_p.S377S	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1526					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						TCACGCATTCCTTGCCCTACT	0.562000													14	64					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39817410	39817410	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:39817410G>A	uc010gnw.2	-	4	469	c.174C>T	c.(172-174)GTC>GTT	p.V58V	ERG_uc002yxa.2_Silent_p.V51V|ERG_uc011aek.1_Intron|ERG_uc010gnv.2_Intron|ERG_uc010gnx.2_Silent_p.V58V|ERG_uc011ael.1_Silent_p.V58V|ERG_uc002yxb.2_Silent_p.V58V|ERG_uc011aem.1_Silent_p.V51V|ERG_uc002yxc.3_Silent_p.V58V	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	58					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CCTGCTGAGGGACGCGTGGGC	0.562000													9	64					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45833815	45833815	+	Missense_Mutation	SNP	G	A	A	rs148308750		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:45833815G>A	uc002zet.1	+	21	3217	c.3004G>A	c.(3004-3006)GAC>AAC	p.D1002N	TRPM2_uc002zeu.1_Missense_Mutation_p.D1002N|TRPM2_uc002zew.1_Missense_Mutation_p.D1002N|TRPM2_uc010gpt.1_Missense_Mutation_p.D1002N|TRPM2_uc002zex.1_Missense_Mutation_p.D788N|TRPM2_uc002zey.1_Missense_Mutation_p.D515N	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1002	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CAATGGCACCGACCCCTACAA	0.607000													79	305					0	0	1	0	0
POTEH	23784	broad.mit.edu	37	22	16266996	16266996	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:16266996G>A	uc010gqp.2	-	9	1505	c.1453C>T	c.(1453-1455)CCA>TCA	p.P485S	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Missense_Mutation_p.P204S|POTEH_uc002zlj.1_Missense_Mutation_p.P320S	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	485										skin(1)	1						TTCCTTGGTGGAATTAATCCA	0.438000													14	266					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072928	17072928	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:17072928G>A	uc002zlp.1	-	1	773	c.513C>T	c.(511-513)ACC>ACT	p.T171T		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	171					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ACAGGGTGTGGGTATTCATCA	0.612000													21	82					0	0	1	0	0
USP18	11274	broad.mit.edu	37	22	18643005	18643005	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:18643005T>A	uc002zny.2	+	3	562	c.224T>A	c.(223-225)ATG>AAG	p.M75K		NM_017414	NP_059110	Q9UMW8	UBP18_HUMAN	ubiquitin specific protease 18	75					regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway|ubiquitin-dependent protein catabolic process	cytosol|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)	1						GTGTTCGTAATGAATGTGGAC	0.353000													27	115					0	0	1	0	0
TSSK2	23617	broad.mit.edu	37	22	19119651	19119651	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:19119651G>A	uc002zow.2	+	1	1331	c.739G>A	c.(739-741)GAC>AAC	p.D247N	DGCR14_uc002zot.2_3'UTR|DGCR14_uc002zou.2_3'UTR|DGCR14_uc002zov.2_RNA	NM_053006	NP_443732	Q96PF2	TSSK2_HUMAN	testis-specific serine kinase 2	247	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1	Colorectal(54;0.0993)					CGAGTGCAAGGACCTCATCTA	0.612000													31	96					0	0	1	0	0
LZTR1	8216	broad.mit.edu	37	22	21350394	21350394	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:21350394G>A	uc002zto.2	+	18	2315	c.2212G>A	c.(2212-2214)GAC>AAC	p.D738N	LZTR1_uc002ztn.2_Missense_Mutation_p.D697N|LZTR1_uc011ahy.1_Missense_Mutation_p.D719N|LZTR1_uc002ztp.2_Missense_Mutation_p.D44N	NM_006767	NP_006758	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	738					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			ovary(2)|lung(2)	4	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			GCCGCCCGAGGACTCGCTGCA	0.642000													16	86					0	0	1	0	0
OSM	5008	broad.mit.edu	37	22	30659890	30659890	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:30659890C>T	uc003ahb.2	-	3	793	c.741G>A	c.(739-741)AGG>AGA	p.R247R		NM_020530	NP_065391	P13725	ONCM_HUMAN	oncostatin M precursor	247					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			skin(1)	1			Epithelial(10;0.206)			GCAGCTGTCCCCTGGTCATGA	0.657000													40	203					0	0	1	0	0
SEC14L3	266629	broad.mit.edu	37	22	30864540	30864540	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:30864540C>T	uc003ahy.2	-	5	467	c.378G>A	c.(376-378)AGG>AGA	p.R126R	SEC14L3_uc003ahz.2_Silent_p.R49R|SEC14L3_uc003aia.2_Silent_p.R67R|SEC14L3_uc003aib.2_Silent_p.R67R	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	126	CRAL-TRIO.					integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	GCTCACAGTCCCTCATCTTGG	0.612000													26	122					0	0	1	0	0
MORC2	22880	broad.mit.edu	37	22	31338098	31338098	+	Splice_Site	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:31338098C>T	uc003aje.1	-	8	1764	c.400_splice	c.e8+1	p.G134_splice		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2								ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						AGCCTACTTACCGCTGTCCCC	0.502000													16	78					0	0	1	0	0
C22orf30	253143	broad.mit.edu	37	22	32108221	32108221	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:32108221G>A	uc003alp.3	-	4	5797	c.5604C>T	c.(5602-5604)TCC>TCT	p.S1868S	C22orf30_uc003alo.1_Silent_p.S1667S|C22orf30_uc010gwj.1_Silent_p.S1667S	NM_173566	NP_775837	Q5THK1	PR14L_HUMAN	hypothetical protein LOC253143	1868											0						TGTCTGCTATGGAGGCTGGAG	0.527000													24	121					0	0	1	0	0
ISX	91464	broad.mit.edu	37	22	35478514	35478514	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:35478514G>A	uc003anj.2	+	2	1184	c.233G>A	c.(232-234)GGA>GAA	p.G78E	ISX_uc011amg.1_Missense_Mutation_p.G66E	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	78						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						CATGCAGAAGGAAGGAAGAGC	0.547000													22	91					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823276	38823276	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:38823276C>T	uc003avs.1	-	2	959	c.862G>A	c.(862-864)GTC>ATC	p.V288I	KCNJ4_uc003avt.1_Missense_Mutation_p.V288I	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	288	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					TCCAGGATGACCACGATCTCA	0.627000													9	52					0	0	1	0	0
A4GALT	53947	broad.mit.edu	37	22	43088980	43088980	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:43088980G>A	uc003bdb.2	-	3	1239	c.978C>T	c.(976-978)TTC>TTT	p.F326F	A4GALT_uc010gzd.2_Silent_p.F326F	NM_017436	NP_059132	Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	326	Lumenal (Potential).				glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			central_nervous_system(2)	2						ACGTGGCCTCGAACCGCGTGC	0.627000													13	41					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50728628	50728628	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:50728628G>A	uc003bkv.3	-	3	492	c.386C>T	c.(385-387)TCC>TTC	p.S129F		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	129	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGGCGGAGGGAGATGTTGCT	0.652000													8	36					0	0	1	0	0
SHANK3	85358	broad.mit.edu	37	22	51159460	51159460	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr22:51159460G>A	uc003bne.1	+	22	3247	c.3247G>A	c.(3247-3249)GAC>AAC	p.D1083N	SHANK3_uc003bnf.1_Missense_Mutation_p.D530N|SHANK3_uc010hbg.1_Missense_Mutation_p.D265N	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1083										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CGCCGGCCGCGACCTGCTGCT	0.736000													9	22					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4854888	4854888	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:4854888G>A	uc003bqa.2	+	54	7735	c.7387G>A	c.(7387-7389)GAG>AAG	p.E2463K	ITPR1_uc010hca.1_Missense_Mutation_p.E2448K|ITPR1_uc011asu.1_Missense_Mutation_p.E474K|ITPR1_uc003bqc.2_Missense_Mutation_p.E1433K|ITPR1_uc010hcc.1_Missense_Mutation_p.E231K|ITPR1_uc011asv.1_Missense_Mutation_p.E187K	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2511	Lumenal (Potential).|Interaction with ERP44 (By similarity).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGAGAGTGGGGAGAACTGCTC	0.512000													26	164					0	0	1	0	0
BHLHE40	8553	broad.mit.edu	37	3	5023178	5023179	+	Silent	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:5023178_5023179CC>TT	uc003bqf.2	+	4	667_668	c.360_361CC>TT	c.(358-363)GCCCTG>GCTTTG	p.120_121AL>AL	uc003bqe.1_5'Flank|uc010hce.1_5'Flank|BHLHE40_uc011asw.1_5'UTR	NM_003670	NP_003661	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	120_121						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAATCATTGCCCTGCAGAGTGG	0.441000													69	441					0	0	1	0	0
ARL8B	55207	broad.mit.edu	37	3	5214354	5214354	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:5214354C>T	uc003bqg.2	+	4	522	c.301C>T	c.(301-303)CGT>TGT	p.R101C	ARL8B_uc011asx.1_Missense_Mutation_p.R92C|ARL8B_uc011asy.1_Missense_Mutation_p.R101C	NM_018184	NP_060654	Q9NVJ2	ARL8B_HUMAN	ADP-ribosylation factor-like 10C	101					cell cycle|cell division|chromosome segregation|small GTPase mediated signal transduction	late endosome membrane|lysosomal membrane|midbody|spindle midzone	alpha-tubulin binding|beta-tubulin binding|GDP binding|GTP binding|GTPase activity				0				OV - Ovarian serous cystadenocarcinoma(96;0.0717)|Epithelial(13;0.0777)		TGCTGCAGATCGTGAAAAGAT	0.318000													14	93					0	0	1	0	0
C3orf32	51066	broad.mit.edu	37	3	8667946	8667946	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:8667946G>A	uc003bqu.2	-	9	916	c.670C>T	c.(670-672)CTG>TTG	p.L224L	C3orf32_uc003bqz.2_Silent_p.L224L|C3orf32_uc003bqt.2_Silent_p.L173L|C3orf32_uc011atg.1_Silent_p.L246L|C3orf32_uc003bqv.2_Silent_p.L173L|C3orf32_uc003bqw.2_RNA|C3orf32_uc003bqx.2_RNA|C3orf32_uc003bqy.2_Silent_p.L224L	NM_015931	NP_057015	Q9Y2M2	CC032_HUMAN	hypothetical protein LOC51066	224										skin(1)	1						AAGTGCAACAGCTTCTTCTCC	0.567000													101	235					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9057395	9057395	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:9057395C>T	uc003brf.1	-	15	2375	c.1699G>A	c.(1699-1701)GAT>AAT	p.D567N	SRGAP3_uc003brg.1_Missense_Mutation_p.D543N|SRGAP3_uc003bri.1_RNA	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	567	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCATTTTGATCGTCCACAAGG	0.443000			T	RAF1	pilocytic astrocytoma								17	63					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9166573	9166573	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:9166573G>A	uc003brf.1	-	2	772	c.96C>T	c.(94-96)TTC>TTT	p.F32F	SRGAP3_uc003brg.1_Silent_p.F32F|SRGAP3_uc003bri.1_RNA|SRGAP3_uc003brk.2_Silent_p.F32F	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	32	FCH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCAGACATTTGAACTGCTCCA	0.607000			T	RAF1	pilocytic astrocytoma								18	64					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10089677	10089677	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:10089677C>T	uc003buw.2	+	16	1433	c.1355C>T	c.(1354-1356)TCA>TTA	p.S452L	FANCD2_uc003bux.1_Missense_Mutation_p.S452L|FANCD2_uc003buy.1_Missense_Mutation_p.S452L|FANCD2_uc010hcw.1_5'Flank	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	452					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		AGTATAATTTCATTTGGCAGT	0.403000			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				11	161					0	0	1	0	0
SLC6A11	6538	broad.mit.edu	37	3	10970962	10970962	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:10970962G>A	uc003bvz.2	+	10	1342	c.1308G>A	c.(1306-1308)CGG>CGA	p.R436R		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	436					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GTTACCGGCGGGAGCTGCTCA	0.562000													49	250					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11064035	11064035	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:11064035C>T	uc010hdq.2	+	7	1006	c.595C>T	c.(595-597)CAG>TAG	p.Q199*		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	199	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	CAACATGCATCAGATGACGGA	0.592000													10	71					0	0	1	0	0
HRH1	3269	broad.mit.edu	37	3	11301793	11301793	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:11301793C>T	uc010hdr.2	+	2	1412	c.1070C>T	c.(1069-1071)TCC>TTC	p.S357F	HRH1_uc010hds.2_Missense_Mutation_p.S357F|HRH1_uc010hdt.2_Missense_Mutation_p.S357F|HRH1_uc003bwb.3_Missense_Mutation_p.S357F	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	357	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GATAGCCAATCCTTCTCTCGA	0.517000													25	84					0	0	1	0	0
CHCHD4	131474	broad.mit.edu	37	3	14154632	14154632	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:14154632C>T	uc003byj.3	-	3	379	c.184G>A	c.(184-186)GGT>AGT	p.G62S	CHCHD4_uc003byi.3_Missense_Mutation_p.G75S	NM_001098502	NP_001091972	Q8N4Q1	MIA40_HUMAN	coiled-coil-helix-coiled-coil-helix domain	62	CHCH.				protein transport|transmembrane transport	mitochondrial intermembrane space					0						CCACAGGGACCGCTGGCCATT	0.493000													17	86					0	0	1	0	0
LSM3	27258	broad.mit.edu	37	3	14223144	14223144	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:14223144G>A	uc003byn.2	+	2	135	c.106G>A	c.(106-108)GAC>AAC	p.D36N	XPC_uc011ave.1_5'Flank|XPC_uc011avf.1_5'Flank|XPC_uc011avg.1_5'Flank	NM_014463	NP_055278	P62310	LSM3_HUMAN	Lsm3 protein	36					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	catalytic step 2 spliceosome|cytosol	protein binding|RNA binding			ovary(1)	1						AATGAGAAATGACCGAGAGCT	0.363000													28	107					0	0	1	0	0
GALNTL2	117248	broad.mit.edu	37	3	16252648	16252648	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:16252648G>A	uc003car.3	+	5	1572	c.1097G>A	c.(1096-1098)GGA>GAA	p.G366E	GALNTL2_uc003caq.3_Missense_Mutation_p.G99E	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	366	Lumenal (Potential).|Catalytic subdomain B.					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GTGGTGCCCGGAGAGGTGGTG	0.577000													13	85					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17051447	17051447	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:17051447C>T	uc011awc.1	+	5	690	c.585C>T	c.(583-585)TTC>TTT	p.F195F	PLCL2_uc010het.1_Silent_p.F77F|PLCL2_uc011awd.1_Silent_p.F77F	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	203	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CAGACATATTCCGCAGCAATG	0.428000													25	120					0	0	1	0	0
RBMS3	27303	broad.mit.edu	37	3	29925699	29925699	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:29925699G>A	uc003cel.2	+	8	1021	c.791G>A	c.(790-792)GGA>GAA	p.G264E	RBMS3_uc003cek.2_Missense_Mutation_p.G264E|RBMS3_uc010hfq.2_Missense_Mutation_p.G277E|RBMS3_uc003cem.2_Missense_Mutation_p.G263E|RBMS3_uc010hfr.2_Missense_Mutation_p.G264E	NM_001003793	NP_001003793	Q6XE24	RBMS3_HUMAN	RNA binding motif, single stranded interacting	264						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)	1		Ovarian(412;0.0956)				ATACAGAATGGGTAAGTAGAT	0.343000													7	49					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35729321	35729321	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:35729321G>A	uc003cgb.2	+	6	616	c.352G>A	c.(352-354)GAT>AAT	p.D118N	ARPP21_uc003cga.2_Missense_Mutation_p.D118N|ARPP21_uc011axy.1_Missense_Mutation_p.D118N|ARPP21_uc003cgf.2_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	118						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AAAAGAAAAGGATAAAAACAA	0.353000													15	41					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35770838	35770839	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:35770838_35770839CC>TT	uc003cgb.2	+	15	1533_1534	c.1269_1270CC>TT	c.(1267-1272)TCCCGC>TCTTGC	p.R424C	ARPP21_uc003cga.2_Missense_Mutation_p.R370C|ARPP21_uc011axy.1_Missense_Mutation_p.R390C|ARPP21_uc003cgf.2_Missense_Mutation_p.R225C|ARPP21_uc003cgg.2_5'UTR	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	424						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GATCGCTGTCCCGCACCCATCC	0.554000													13	72					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36897417	36897417	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:36897417C>T	uc003cgj.2	-	3	2316	c.2014G>A	c.(2014-2016)GAA>AAA	p.E672K		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1222					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CTTCCATCTTCGTTTCTCAGA	0.483000													29	59					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898287	36898287	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:36898287C>T	uc003cgj.2	-	3	1446	c.1144G>A	c.(1144-1146)GGT>AGT	p.G382S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	932					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TTATTGATACCTTTCAGCTTC	0.502000													18	79					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38035943	38035943	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:38035943C>T	uc003chj.2	+	4	613	c.327C>T	c.(325-327)TTC>TTT	p.F109F	VILL_uc003chk.1_Silent_p.F109F|VILL_uc003chl.2_Silent_p.F109F|VILL_uc010hgu.2_5'UTR	NM_015873	NP_056957	O15195	VILL_HUMAN	villin-like protein	109					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton				0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GCAGCTACTTCCGCCCGGGAA	0.697000													12	50					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38627269	38627269	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:38627269G>A	uc003cio.2	-	16	2894	c.2700C>T	c.(2698-2700)ATC>ATT	p.I900I	SCN5A_uc003cin.2_Silent_p.I900I|SCN5A_uc003cil.3_Silent_p.I900I|SCN5A_uc010hhi.2_Silent_p.I900I|SCN5A_uc010hhk.2_Silent_p.I900I|SCN5A_uc011ayr.1_Silent_p.I900I|SCN5A_uc010hhj.1_Silent_p.I511I	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	900					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	ACATGGTCTCGATCCACTCTC	0.542000													52	118					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739534	38739534	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:38739534T>A	uc003ciq.2	-	27	5177	c.5177A>T	c.(5176-5178)AAT>ATT	p.N1726I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1726					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CGTGGCCACATTGAAGTTCTC	0.502000													34	81					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38927694	38927694	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:38927694C>T	uc011ays.1	-	16	3070	c.2871G>A	c.(2869-2871)ACG>ACA	p.T957T	SCN11A_uc010hhn.1_Intron	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	957					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CTCTCTGGCTCGTGGGCTTCT	0.443000													9	50					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38936092	38936092	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:38936092C>T	uc011ays.1	-	15	2966	c.2767G>A	c.(2767-2769)GAA>AAA	p.E923K	SCN11A_uc010hhn.1_Missense_Mutation_p.E39K	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	923					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ACGTCATCTTCCTCCTCCGCA	0.498000													41	104					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39228702	39228702	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:39228702G>A	uc003cjk.1	-	2	2456	c.2235C>T	c.(2233-2235)ATC>ATT	p.I745I	XIRP1_uc003cji.2_Silent_p.I745I|XIRP1_uc003cjj.2_Intron	NM_194293	NP_919269	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	745							actin binding			ovary(4)|breast(2)|central_nervous_system(1)|pancreas(1)	8				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TGCCCCCTTGGATGCTCTCAG	0.612000													17	36					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42787503	42787503	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:42787503A>G	uc003cly.3	-	7	821	c.737T>C	c.(736-738)GTT>GCT	p.V246A		NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	246	Potential.									ovary(1)	1						GTCTTCCCCAACCTCTCTGGC	0.512000													16	95					0	0	1	0	0
CCBP2	1238	broad.mit.edu	37	3	42906109	42906109	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:42906109G>A	uc003cme.2	+	3	294	c.115G>A	c.(115-117)GAT>AAT	p.D39N	CCBP2_uc003cmd.1_Missense_Mutation_p.D39N|CCBP2_uc003cmf.2_Missense_Mutation_p.D39N|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Intron	NM_001296	NP_001287	O00590	CCBP2_HUMAN	chemokine binding protein 2	39	Extracellular (Potential).				chemotaxis|immune response|multicellular organismal development	integral to plasma membrane	C-X-C chemokine receptor activity			lung(4)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CTGCAGGAAGGATGCAGTGGT	0.512000													23	111					0	0	1	0	0
FYCO1	79443	broad.mit.edu	37	3	46014621	46014621	+	Silent	SNP	C	T	T	rs149291592	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:46014621C>T	uc003cpb.3	-	6	704	c.498G>A	c.(496-498)TCG>TCA	p.S166S	FYCO1_uc011bal.1_Silent_p.S166S	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	166	RUN.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CAAAGCCCCTCGACGCCAGGT	0.483000													13	87					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46307675	46307675	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:46307675C>T	uc003cpg.1	+	4	1569	c.1026C>T	c.(1024-1026)GTC>GTT	p.V342V	CCR3_uc003cpi.1_Silent_p.V342V|CCR3_uc003cpj.1_Silent_p.V342V|CCR3_uc003cpk.1_Silent_p.V363V|CCR3_uc010hjb.1_Silent_p.V360V|CCR3_uc003cpl.1_Silent_p.V375V	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	342	Cytoplasmic (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CCAGCTCTGTCTCTCCATCCA	0.488000													10	45					0	0	1	0	0
CCR2	729230	broad.mit.edu	37	3	46399786	46399786	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:46399786G>A	uc003cpn.3	+	2	1253	c.768G>A	c.(766-768)TGG>TGA	p.W256*	CCR2_uc003cpm.3_Nonsense_Mutation_p.W256*	NM_001123041	NP_001116513	P41597	CCR2_HUMAN	chemokine (C-C motif) receptor 2 isoform A	256	Helical; Name=6; (Potential).				astrocyte cell migration|blood vessel remodeling|cellular defense response|chemokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response|interspecies interaction between organisms|JAK-STAT cascade|monocyte extravasation|negative regulation of adenylate cyclase activity|negative regulation of angiogenesis|negative regulation of eosinophil degranulation|negative regulation of type 2 immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of immune complex clearance by monocytes and macrophages|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|positive regulation of T cell extravasation|positive regulation of T-helper 1 type immune response|positive regulation of tumor necrosis factor biosynthetic process|regulation of vascular endothelial growth factor production|T-helper 17 cell chemotaxis	cytosol|dendrite|integral to plasma membrane|perikaryon|perinuclear region of cytoplasm|soluble fraction	C-C chemokine receptor activity|CCR2 chemokine receptor binding|protein homodimerization activity			lung(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0174)|Kidney(197;0.0206)		TTCTCTTCTGGACTCCCTATA	0.478000													43	118					0	0	1	0	0
CDC25A	993	broad.mit.edu	37	3	48219361	48219361	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:48219361C>T	uc003csh.1	-	7	1031	c.667G>A	c.(667-669)GAT>AAT	p.D223N	CDC25A_uc003csi.1_Missense_Mutation_p.D183N	NM_001789	NP_001780	P30304	MPIP1_HUMAN	cell division cycle 25A isoform a	223					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|kidney(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TTCTCTCCATCGAGAAGGTCC	0.443000													41	209					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48698456	48698456	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:48698456C>T	uc003cul.2	-	1	1893	c.1612G>A	c.(1612-1614)GAG>AAG	p.E538K	CELSR3_uc003cuf.1_Missense_Mutation_p.E608K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	538	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TTGTCGTTCTCGTCTAGCACA	0.637000													12	59					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49690916	49690917	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:49690916_49690917CC>TT	uc003cxe.3	+	5	4041_4042	c.3927_3928CC>TT	c.(3925-3930)ACCCCT>ACTTCT	p.P1310S		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1310					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCCCCCTTACCCCTGGTACCAG	0.559000													33	143					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52406983	52406983	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:52406983C>T	uc011bef.1	+	44	7160	c.6899C>T	c.(6898-6900)GCC>GTC	p.A2300V		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2300	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AACATGCCGGCCCTGGAGACC	0.617000													13	131					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52553575	52553575	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:52553575C>T	uc003dej.2	+	50	5304	c.5230C>T	c.(5230-5232)CTG>TTG	p.L1744L	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1744	Extracellular (Potential).|FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CAGCGGCCTCCTGAAGGTACT	0.567000													9	84					0	0	1	0	0
NT5DC2	64943	broad.mit.edu	37	3	52568562	52568562	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:52568562G>A	uc003deo.2	-	1	532	c.108C>T	c.(106-108)AAC>AAT	p.N36N	NT5DC2_uc003den.2_5'Flank|NT5DC2_uc010hmi.2_5'Flank|NT5DC2_uc010hmj.2_5'UTR|LOC440957_uc003dep.2_5'Flank	NM_022908	NP_075059	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2 isoform 2	36							hydrolase activity|metal ion binding				0				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		TCAACTCCCGGTTTCCCGGCG	0.627000													42	120					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55107561	55107561	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:55107561C>T	uc003dhf.2	+	36	3125	c.3077C>T	c.(3076-3078)ACC>ATC	p.T1026I	CACNA2D3_uc003dhg.1_Missense_Mutation_p.T932I|CACNA2D3_uc003dhh.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	1026	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GCCCCCATCACCATGGCACCC	0.522000													18	57					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468790	56468790	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:56468790C>T	uc003dhr.1	-	2	502	c.246G>A	c.(244-246)CTG>CTA	p.L82L		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	82						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TAGCCCTTCCCAGAGTCATAG	0.512000													23	168					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64085072	64085072	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:64085072C>T	uc003dmf.2	-	8	2776	c.2190G>A	c.(2188-2190)CGG>CGA	p.R730R		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	730	Arg-rich.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CCTGGAAGCTCCGCTGGCGCA	0.622000													16	70					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65415300	65415301	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:65415300_65415301CC>TT	uc003dmn.2	-	12	2587_2588	c.2061_2062GG>AA	c.(2059-2064)GTGGAA>GTAAAA	p.E688K	MAGI1_uc003dmm.2_Missense_Mutation_p.E688K|MAGI1_uc003dmo.2_Missense_Mutation_p.E688K|MAGI1_uc003dmp.2_Missense_Mutation_p.E688K|MAGI1_uc010hny.2_Missense_Mutation_p.E573K	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	688	PDZ 3.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TTATTAACTTCCACTATGAGAT	0.500000													8	72					0	0	1	0	0
FRMD4B	23150	broad.mit.edu	37	3	69245538	69245538	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:69245538G>A	uc003dnv.2	-	14	1392	c.1102C>T	c.(1102-1104)CCT>TCT	p.P368S	FRMD4B_uc003dnw.2_Intron|FRMD4B_uc003dnu.2_Missense_Mutation_p.P20S|FRMD4B_uc011bga.1_Missense_Mutation_p.P212S	NM_015123	NP_055938	Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	368						cytoplasm|cytoskeleton	binding			ovary(3)|central_nervous_system(1)	4		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		CTGGCTGAAGGAATTTTTGCC	0.363000													8	60					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93598096	93598096	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:93598096C>T	uc003drb.3	-	13	1896	c.1555G>A	c.(1555-1557)GGC>AGC	p.G519S	PROS1_uc010hoo.2_Missense_Mutation_p.G388S|PROS1_uc003dqz.3_Missense_Mutation_p.G388S	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	519	Laminin G-like 2.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ACACCAGTGCCCGTGGATGGA	0.428000													22	107					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96706696	96706696	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:96706696G>A	uc010how.1	+	3	1016	c.973G>A	c.(973-975)GAA>AAA	p.E325K	EPHA6_uc003drp.1_Missense_Mutation_p.E325K	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	230	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CTCTTTGGTTGAAGTACGGGG	0.473000													32	106					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96945212	96945212	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:96945212G>A	uc010how.1	+	4	1262	c.1219G>A	c.(1219-1221)GAA>AAA	p.E407K	EPHA6_uc003drp.1_Missense_Mutation_p.E407K	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	312	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CTGTCAGTGTGAAAAGGGTTA	0.398000													44	136					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	97356782	97356782	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:97356782G>A	uc010how.1	+	14	2683	c.2640G>A	c.(2638-2640)ATG>ATA	p.M880I	EPHA6_uc011bgp.1_3'UTR|EPHA6_uc003drs.3_Missense_Mutation_p.M272I|EPHA6_uc003drr.3_Missense_Mutation_p.M272I|EPHA6_uc003drt.2_Missense_Mutation_p.M272I|EPHA6_uc010hox.1_RNA	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	785	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CATCAGGCATGAAGTATCTTT	0.418000													39	168					0	0	1	0	0
CRYBG3	131544	broad.mit.edu	37	3	97619322	97619322	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:97619322C>T	uc003drx.2	+	12	2217	c.2153C>T	c.(2152-2154)CCG>CTG	p.P718L		NM_153605	NP_705833			beta-gamma crystallin domain containing 3												0						AATGAACCTCCGCATTTGGTA	0.274000													3	11					0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806295	97806295	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:97806295G>A	uc011bgs.1	+	1	279	c.279G>A	c.(277-279)ATG>ATA	p.M93I		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGACTGCAATGATATCCCTAG	0.438000													48	194					0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806481	97806481	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:97806481C>T	uc011bgs.1	+	1	465	c.465C>T	c.(463-465)TTC>TTT	p.F155F		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TAATTGGTTTCCTGCATCCTC	0.363000													36	168					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97887907	97887907	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:97887907C>T	uc011bgu.1	+	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGCATATGATCGCTATGTAGC	0.378000													14	80					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97888463	97888463	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:97888463G>A	uc011bgu.1	+	1	920	c.920G>A	c.(919-921)AGA>AAA	p.R307K		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATGTTAAAAAGAAATGTTAAG	0.303000													4	11					0	0	1	0	0
ZBTB11	27107	broad.mit.edu	37	3	101384585	101384585	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:101384585G>T	uc003dve.3	-	4	1076	c.846C>A	c.(844-846)TTC>TTA	p.F282L		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	282	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CCATGCTACAGAAATCAAAAC	0.373000													11	37					0.00136819	0.00137234	1	1	0
NFKBIZ	64332	broad.mit.edu	37	3	101576282	101576282	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:101576282C>T	uc003dvp.2	+	11	2197	c.2082C>T	c.(2080-2082)CCC>CCT	p.P694P	NFKBIZ_uc003dvo.2_Silent_p.P594P|NFKBIZ_uc010hpo.2_Silent_p.P594P|NFKBIZ_uc003dvq.2_Silent_p.P572P	NM_031419	NP_113607	Q9BYH8	IKBZ_HUMAN	nuclear factor of kappa light polypeptide gene	694	Interaction with NFKB1/p50 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(2)	2						ATTTGGTTCCCGATGGCCCTG	0.532000													16	56					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108229378	108229378	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:108229378C>T	uc003dxa.1	-	2	117	c.60G>A	c.(58-60)AAG>AAA	p.K20K		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	20	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						ACAGATCCATCTTTATTAAAG	0.423000													15	32					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603641	111603641	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:111603641G>A	uc010hqa.2	+	2	1128	c.717G>A	c.(715-717)AGG>AGA	p.R239R	PHLDB2_uc003dyc.2_Silent_p.R266R|PHLDB2_uc003dyd.2_Silent_p.R239R|PHLDB2_uc003dyg.2_Silent_p.R239R|PHLDB2_uc003dyh.2_Silent_p.R239R|PHLDB2_uc003dye.3_Silent_p.R239R|PHLDB2_uc003dyf.3_Silent_p.R239R	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	239						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TGAGAACTAGGAAGTACTCCA	0.507000													9	74					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603908	111603908	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:111603908C>T	uc010hqa.2	+	2	1395	c.984C>T	c.(982-984)ACC>ACT	p.T328T	PHLDB2_uc003dyc.2_Silent_p.T355T|PHLDB2_uc003dyd.2_Silent_p.T328T|PHLDB2_uc003dyg.2_Silent_p.T328T|PHLDB2_uc003dyh.2_Silent_p.T328T|PHLDB2_uc003dye.3_Silent_p.T328T|PHLDB2_uc003dyf.3_Silent_p.T328T	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	328						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						TAAGTTCTACCCTCAGTGTCC	0.468000													15	49					0	0	1	0	0
CD200	4345	broad.mit.edu	37	3	112066513	112066513	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:112066513C>T	uc003dyw.2	+	5	749	c.605C>T	c.(604-606)TCA>TTA	p.S202L	CD200_uc010hqd.1_Missense_Mutation_p.S61L|CD200_uc003dyx.2_Missense_Mutation_p.S177L|CD200_uc003dyy.2_Missense_Mutation_p.S61L|CD200_uc003dyz.2_Missense_Mutation_p.S103L	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	177	Ig-like C2-type.|Extracellular (Potential).				regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				GTCCCTCGGTCAGGGATTGAA	0.498000													17	96					0	0	1	0	0
KIAA2018	205717	broad.mit.edu	37	3	113375235	113375235	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:113375235G>A	uc003eam.2	-	7	5705	c.5294C>T	c.(5293-5295)TCA>TTA	p.S1765L	KIAA2018_uc003eal.2_Missense_Mutation_p.S1709L	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1765					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						CCGCAATGATGATACAGGGTT	0.428000													37	90					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120976074	120976074	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:120976074C>T	uc003eec.3	+	17	1866	c.1726C>T	c.(1726-1728)CCG>TCG	p.P576S	STXBP5L_uc011bji.1_Missense_Mutation_p.P576S	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	576	WD 9.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		AACAAGTCCTCCGTTTCCAGA	0.388000													26	91					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121634153	121634153	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:121634153C>T	uc003eep.2	+	6	761	c.608C>T	c.(607-609)CCC>CTC	p.P203L	SLC15A2_uc011bjn.1_Missense_Mutation_p.P172L	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	203	Helical; (Potential).				protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TTTATCACACCCATGCTGAGA	0.443000													15	58					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647961	121647961	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:121647961C>T	uc003eep.2	+	16	1627	c.1474C>T	c.(1474-1476)CGT>TGT	p.R492C	SLC15A2_uc011bjn.1_Missense_Mutation_p.R461C	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	492					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	TCTTGTCATTCGTGAAGATGG	0.398000													51	202					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121712496	121712496	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:121712496C>T	uc003ees.2	-	7	1206	c.1100G>A	c.(1099-1101)GGG>GAG	p.G367E	ILDR1_uc003eeq.2_Missense_Mutation_p.G335E|ILDR1_uc003eer.2_Missense_Mutation_p.G323E|ILDR1_uc010hrg.2_Missense_Mutation_p.G278E	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	367	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		GTGGCTTCTCCCCTCCCTCAG	0.592000													15	72					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122002865	122002865	+	Silent	SNP	C	T	T	rs150869744	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:122002865C>T	uc003eev.3	+	7	2436	c.2064C>T	c.(2062-2064)TTC>TTT	p.F688F	CASR_uc003eew.3_Silent_p.F698F	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	688	Helical; Name=3; (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCATCAGCTTCGTGCTCTGCA	0.612000													29	80					0	0	1	0	0
SEMA5B	54437	broad.mit.edu	37	3	122645327	122645328	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:122645327_122645328CC>TT	uc003efz.1	-	9	1351_1352	c.1047_1048GG>AA	c.(1045-1050)CCGGGC>CCAAGC	p.G350S	SEMA5B_uc011bju.1_Missense_Mutation_p.G292S|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.G350S|SEMA5B_uc010hro.1_Missense_Mutation_p.G292S|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	350	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		GGGACCTCGCCCGGGCGGGAGC	0.604000													16	42					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124201686	124201686	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:124201686C>T	uc003ehg.2	+	28	4344	c.4217C>T	c.(4216-4218)TCC>TTC	p.S1406F	KALRN_uc010hrv.1_Missense_Mutation_p.S1397F|KALRN_uc003ehf.1_Missense_Mutation_p.S1406F|KALRN_uc011bjy.1_Missense_Mutation_p.S1397F|KALRN_uc003ehh.1_Missense_Mutation_p.S752F	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1406	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTGGCCAACTCCATCTCTTCC	0.512000													22	123					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127339643	127339643	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:127339643G>A	uc003ejp.2	+	14	2425	c.2368G>A	c.(2368-2370)GAC>AAC	p.D790N	MCM2_uc011bkm.1_Missense_Mutation_p.D660N|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Missense_Mutation_p.D743N	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	790					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding	p.D790N(1)		ovary(3)|skin(1)	4						GATCGAAGACGACGTCAACAT	0.597000													56	148					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127646797	127646797	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:127646797C>T	uc010hsr.2	+	2	1264	c.1261C>T	c.(1261-1263)CCC>TCC	p.P421S	KBTBD12_uc003ejy.3_Missense_Mutation_p.P28S|KBTBD12_uc010hsq.2_Intron|KBTBD12_uc003eka.3_Intron|KBTBD12_uc003ejz.2_Missense_Mutation_p.P421S	NM_207335	NP_997218	Q3ZCT8	KBTBC_HUMAN	kelch domain containing 6	421	Kelch 1.									ovary(1)	1						AAGGGTGTCTCCCCTTCCACT	0.378000													15	32					0	0	1	0	0
Unknown	0	broad.mit.edu	37	3	129127593	129127593	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:129127593C>T	uc003emg.2	-	6	1307	c.1144G>A	c.(1144-1146)GAG>AAG	p.E382K		NM_207307	NP_997190			hypothetical protein LOC90288																		TCAATGAGCTCCCTCATATCC	0.577000													3	16					0	0	1	0	0
COL6A6	131873	broad.mit.edu	37	3	130292941	130292941	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:130292941G>A	uc010htl.2	+	7	3150	c.3119G>A	c.(3118-3120)GGA>GAA	p.G1040E		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1040	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GTGCGAATAGGAGCGGCCCAG	0.423000													6	18					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140265383	140265383	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:140265383G>T	uc003etn.2	+	10	1724	c.1534G>T	c.(1534-1536)GCT>TCT	p.A512S	CLSTN2_uc003etm.2_Missense_Mutation_p.A512S	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	512	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						ACCACAGTTTGCTCAGTTCTT	0.527000										HNSCC(16;0.037)			16	41					1.99824e-07	2.01282e-07	1	1	0
PLS1	5357	broad.mit.edu	37	3	142405184	142405184	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:142405184G>A	uc010huv.2	+	9	1106	c.947G>A	c.(946-948)GGA>GAA	p.G316E	PLS1_uc003euz.2_Missense_Mutation_p.G316E|PLS1_uc003eva.2_Missense_Mutation_p.G316E	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	316	Actin-binding 1.|CH 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						GGGGAAGATGGACCTGCCATT	0.289000													23	136					0	0	1	0	0
CPA3	1359	broad.mit.edu	37	3	148596241	148596241	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:148596241G>A	uc003ewm.2	+	4	335	c.283G>A	c.(283-285)GAT>AAT	p.D95N		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	95					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTTGATTCATGATCTACAAGA	0.338000													18	79					0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151012039	151012039	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:151012039C>T	uc003eyt.2	-	3	1356	c.995G>A	c.(994-996)AGA>AAA	p.R332K	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	G protein-coupled receptor 87	332	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACTCCTGGTTCTGATATTTGA	0.363000													40	139					0	0	1	0	0
P2RY13	53829	broad.mit.edu	37	3	151046014	151046014	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:151046014G>A	uc003eyv.2	-	2	851	c.830C>T	c.(829-831)CCA>CTA	p.P277L	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron	NM_176894	NP_795713	Q9BPV8	P2Y13_HUMAN	purinergic receptor P2Y, G-protein coupled, 13	277	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(3)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0189)|Lung(72;0.0278)			GTGAGTATATGGAACTCTGGC	0.368000													19	36					0	0	1	0	0
IFT80	57560	broad.mit.edu	37	3	160073835	160073835	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:160073835G>A	uc011boy.1	-	8	1176	c.743C>T	c.(742-744)TCG>TTG	p.S248L	IFT80_uc003fda.2_RNA|IFT80_uc003fdb.1_Missense_Mutation_p.S111L|IFT80_uc003fdd.1_5'UTR|IFT80_uc003fde.1_Missense_Mutation_p.S111L	NM_020800	NP_065851	Q9P2H3	IFT80_HUMAN	WD repeat domain 56	248	WD 5.					cilium axoneme|microtubule basal body				ovary(1)	1			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AGTATGAAACGATCCAACAGC	0.443000													21	111					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161221265	161221265	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:161221265G>A	uc011bpb.1	+	4	969	c.969G>A	c.(967-969)GGG>GGA	p.G323G		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	323	Collagen-like 3.					collagen					0						GCCCCACTGGGAAGAAGGGCT	0.567000													6	20					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164783091	164783091	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:164783091C>T	uc003fei.2	-	7	827	c.765G>A	c.(763-765)TGG>TGA	p.W255*		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	255	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCCATGTTTTCCAGGATAAAT	0.338000										HNSCC(35;0.089)			17	48					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167245782	167245782	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:167245782C>T	uc003fev.1	-	11	1680	c.1374G>A	c.(1372-1374)AAG>AAA	p.K458K	WDR49_uc003feu.1_Silent_p.K283K|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	458										large_intestine(1)|ovary(1)|skin(1)	3						TGATTTTGTTCTTACTGGAGT	0.358000													10	41					0	0	1	0	0
SERPINI1	5274	broad.mit.edu	37	3	167508198	167508198	+	Missense_Mutation	SNP	G	A	A	rs61750375	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:167508198G>A	uc003ffa.3	+	3	487	c.289G>A	c.(289-291)GTA>ATA	p.V97I	SERPINI1_uc003ffb.3_Missense_Mutation_p.V97I	NM_001122752	NP_001116224	Q99574	NEUS_HUMAN	neuroserpin precursor	97					central nervous system development|peripheral nervous system development|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(1)	1						TTCAAACATGGTAACTGCTAA	0.338000													10	51					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168834131	168834131	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:168834131G>A	uc003ffi.3	-	7	1234	c.965C>T	c.(964-966)TCT>TTT	p.S322F	MECOM_uc010hwk.1_Missense_Mutation_p.S345F|MECOM_uc003ffj.3_Missense_Mutation_p.S387F|MECOM_uc011bpi.1_Missense_Mutation_p.S323F|MECOM_uc003ffn.3_Missense_Mutation_p.S322F|MECOM_uc003ffk.2_Missense_Mutation_p.S322F|MECOM_uc003ffl.2_Missense_Mutation_p.S482F|MECOM_uc011bpj.1_Missense_Mutation_p.S510F|MECOM_uc011bpk.1_Missense_Mutation_p.S312F|MECOM_uc010hwn.2_Missense_Mutation_p.S510F	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	322					apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TTTAACAGGAGAACTAGCAGG	0.453000													14	51					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	170893073	170893073	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:170893073C>T	uc003fhh.2	-	9	1086	c.741G>A	c.(739-741)CGG>CGA	p.R247R	TNIK_uc003fhi.2_Silent_p.R247R|TNIK_uc003fhj.2_Silent_p.R247R|TNIK_uc003fhk.2_Silent_p.R247R|TNIK_uc003fhl.2_Silent_p.R247R|TNIK_uc003fhm.2_Silent_p.R247R|TNIK_uc003fhn.2_Silent_p.R247R|TNIK_uc003fho.2_Silent_p.R247R	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	247	Protein kinase.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			GCGCTGGGTTCCGGGGGATGA	0.512000													3	18					0	0	1	0	0
TTC14	151613	broad.mit.edu	37	3	180327498	180327498	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:180327498C>T	uc003fkk.2	+	12	1613	c.1481C>T	c.(1480-1482)TCT>TTT	p.S494F	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Missense_Mutation_p.S494F	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	494	Ser-rich.|Poly-Ser.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCATCATCCTCTTCCTCTTCT	0.388000													11	37					0	0	1	0	0
MCCC1	56922	broad.mit.edu	37	3	182759359	182759359	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:182759359C>T	uc003fle.2	-	11	1400	c.1263G>A	c.(1261-1263)CGG>CGA	p.R421R	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Silent_p.R304R|MCCC1_uc003flg.2_Silent_p.R312R|MCCC1_uc011bqp.1_Silent_p.R374R	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	421	Biotin carboxylation.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	CTTTACCTTGCCGTACTCCAG	0.418000													9	76					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184100457	184100457	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:184100457C>T	uc003fov.2	+	8	1123	c.877C>T	c.(877-879)CCA>TCA	p.P293S	CHRD_uc003fow.2_5'UTR|CHRD_uc003fox.2_Missense_Mutation_p.P293S|CHRD_uc003foy.2_5'UTR|CHRD_uc010hyc.2_5'UTR|CHRD_uc011brr.1_5'UTR	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	293	CHRD 2.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGAAGGCCCCCCACAGCAGGG	0.587000													28	139					0	0	1	0	0
CHRD	8646	broad.mit.edu	37	3	184106376	184106376	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:184106376G>A	uc003fov.2	+	21	2802	c.2556G>A	c.(2554-2556)GTG>GTA	p.V852V	CHRD_uc003fow.2_Silent_p.V482V|CHRD_uc003fox.2_Silent_p.V852V|CHRD_uc003foy.2_Silent_p.V482V|CHRD_uc010hyc.2_Silent_p.V442V|CHRD_uc011brr.1_Silent_p.V394V	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	852					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTCAACAGTGGGGTCGGGGG	0.587000													53	148					0	0	1	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185390337	185390337	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:185390337G>A	uc003fpo.2	-	10	1271	c.1192C>T	c.(1192-1194)CCC>TCC	p.P398S	IGF2BP2_uc010hyi.2_Missense_Mutation_p.P341S|IGF2BP2_uc010hyj.2_Missense_Mutation_p.P335S|IGF2BP2_uc010hyk.2_Missense_Mutation_p.P262S|IGF2BP2_uc010hyl.2_Intron|IGF2BP2_uc003fpp.2_Intron|IGF2BP2_uc003fpq.2_Missense_Mutation_p.P403S	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	398					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			ACAGTGAAGGGGTGGTAGGGG	0.592000													5	34					0	0	1	0	0
IGF2BP2	10644	broad.mit.edu	37	3	185407293	185407293	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:185407293G>A	uc003fpo.2	-	6	606	c.527C>T	c.(526-528)TCC>TTC	p.S176F	IGF2BP2_uc010hyi.2_Missense_Mutation_p.S119F|IGF2BP2_uc010hyj.2_Missense_Mutation_p.S113F|IGF2BP2_uc010hyk.2_Missense_Mutation_p.S40F|IGF2BP2_uc010hyl.2_Missense_Mutation_p.S113F|IGF2BP2_uc003fpp.2_Missense_Mutation_p.S176F|IGF2BP2_uc003fpq.2_Missense_Mutation_p.S181F	NM_006548	NP_006539	Q9Y6M1	IF2B2_HUMAN	insulin-like growth factor 2 mRNA binding	176					anatomical structure morphogenesis|negative regulation of translation	cytoskeletal part|cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity				0	all_cancers(143;5.84e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTGCTCCCGGGAAGAGTGGTC	0.597000													20	133					0	0	1	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186572062	186572062	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:186572062G>A	uc003fra.2	+	3	388	c.304G>A	c.(304-306)GGA>AGA	p.G102R	ADIPOQ_uc010hyy.2_Missense_Mutation_p.G102R	NM_004797	NP_004788	Q15848	ADIPO_HUMAN	adiponectin precursor	102	Collagen-like.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			ovary(1)	1	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		AGGCAGGAAAGGAGAACCTGG	0.517000													33	90					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193032768	193032768	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:193032768C>T	uc011bsq.1	-	18	2151	c.2151G>A	c.(2149-2151)ATG>ATA	p.M717I		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	717					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TACCTGTAATCATCACAGTCC	0.423000													32	178					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193040355	193040355	+	Silent	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:193040355T>C	uc011bsq.1	-	15	1683	c.1683A>G	c.(1681-1683)GAA>GAG	p.E561E		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	561					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CAATGCAATCTTCCATTTTCT	0.294000													10	60					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193052888	193052888	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:193052888C>T	uc011bsq.1	-	10	944	c.944G>A	c.(943-945)GGA>GAA	p.G315E		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	315					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TATACTTTCTCCTAAAGAGGA	0.398000													8	70					0	0	1	0	0
ATP13A3	79572	broad.mit.edu	37	3	194151735	194151735	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr3:194151735G>A	uc003fty.3	-	23	2963	c.2561C>T	c.(2560-2562)ACC>ATC	p.T854I	ATP13A3_uc003ftz.1_Missense_Mutation_p.T560I	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	854					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		GGCAAACACGGTGCCATGCAA	0.368000													23	88					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3769559	3769559	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:3769559G>T	uc003ghm.2	+	1	1264	c.1226G>T	c.(1225-1227)CGC>CTC	p.R409L	ADRA2C_uc010icx.2_Intron	NM_000683	NP_000674	P18825	ADA2C_HUMAN	alpha-2C-adrenergic receptor	409	Extracellular (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GGCATCTGCCGCGAGGCCTGC	0.597000													3	25					0.004672	0.00468331	1	1	0
EVC	2121	broad.mit.edu	37	4	5731072	5731072	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:5731072C>T	uc003gil.1	+	3	523	c.339C>T	c.(337-339)TTC>TTT	p.F113F	EVC_uc003gim.1_RNA	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	113					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				TCACAGCATTCGCCCTGAAGG	0.483000													15	79					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6863241	6863241	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:6863241C>T	uc003gjr.3	+	7	1595	c.1132C>T	c.(1132-1134)CCT>TCT	p.P378S	KIAA0232_uc003gjq.3_Missense_Mutation_p.P378S	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	378							ATP binding			ovary(2)	2						GAGAAAAGATCCTGGGAGCAC	0.443000													14	48					0	0	1	0	0
C4orf23	152992	broad.mit.edu	37	4	8456500	8456500	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:8456500G>A	uc003glg.1	+	6	664	c.476G>A	c.(475-477)AGA>AAA	p.R159K	C4orf23_uc003glf.1_Missense_Mutation_p.R147K|C4orf23_uc003glh.1_5'UTR	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	388					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						GTCCGAAGAAGAAAAATCTGG	0.398000													7	88					0	0	1	0	0
C4orf23	152992	broad.mit.edu	37	4	8467274	8467274	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:8467274C>T	uc003glg.1	+	8	981	c.793C>T	c.(793-795)CCT>TCT	p.P265S	C4orf23_uc003glf.1_Missense_Mutation_p.P253S|C4orf23_uc003glh.1_Missense_Mutation_p.P102S	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	494					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						CCTCAGGATTCCTTCAACCAA	0.498000													10	55					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784493	9784493	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:9784493C>T	uc003gmb.3	+	1	1236	c.840C>T	c.(838-840)CCC>CCT	p.P280P		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	280	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CCTGCGCGCCCGACACCAGCC	0.637000													10	30					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784543	9784543	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:9784543C>T	uc003gmb.3	+	1	1286	c.890C>T	c.(889-891)ACC>ATC	p.T297I		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	297	Helical; Name=6; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GTTCTCAAGACCCTGTCGGTG	0.632000													9	68					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20550128	20550128	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:20550128G>A	uc003gpr.1	+	23	2567	c.2363G>A	c.(2362-2364)AGA>AAA	p.R788K	SLIT2_uc003gps.1_Missense_Mutation_p.R780K	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	788	LRR 18.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AGTAACAACAGAATAAGCACG	0.368000													3	38					0	0	1	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356150	40356150	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:40356150C>T	uc003gva.1	+	5	1069	c.1053C>T	c.(1051-1053)GTC>GTT	p.V351V		NM_017581	NP_060051	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9	351	Cytoplasmic (Potential).				elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(3)|skin(3)|central_nervous_system(1)	7					Nicotine(DB00184)	TCTTGTTTGTCTATGATGTGG	0.547000													30	265					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648255	41648255	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:41648255G>A	uc003gvu.3	+	11	1268	c.1214G>A	c.(1213-1215)CGA>CAA	p.R405Q	LIMCH1_uc003gvv.3_Missense_Mutation_p.R405Q|LIMCH1_uc003gvw.3_Missense_Mutation_p.R405Q|LIMCH1_uc003gvx.3_Missense_Mutation_p.R393Q|LIMCH1_uc003gwe.3_Missense_Mutation_p.R405Q|LIMCH1_uc003gvy.3_Missense_Mutation_p.R234Q|LIMCH1_uc003gwa.3_Missense_Mutation_p.R246Q|LIMCH1_uc003gvz.3_Missense_Mutation_p.R790Q|LIMCH1_uc011byu.1_Missense_Mutation_p.R239Q|LIMCH1_uc003gwc.3_Missense_Mutation_p.R251Q|LIMCH1_uc003gwd.3_Missense_Mutation_p.R239Q|LIMCH1_uc011byv.1_Missense_Mutation_p.R156Q	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	405	Potential.				actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						ACAAGTGAACGAAGGAAAAGC	0.348000													12	26					0	0	1	0	0
GRXCR1	389207	broad.mit.edu	37	4	42965003	42965003	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:42965003G>A	uc003gwt.2	+	2	479	c.479G>A	c.(478-480)AGA>AAA	p.R160K		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	160	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						GAACTGGTTAGAAAGATTTTC	0.413000													22	80					0	0	1	0	0
GABRG1	2565	broad.mit.edu	37	4	46066510	46066510	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:46066510C>T	uc003gxb.2	-	5	725	c.573G>A	c.(571-573)CAG>CAA	p.Q191Q		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	191	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AGTTATGAAGCTGAAGATAAC	0.289000													11	88					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46314596	46314596	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:46314596C>T	uc003gxc.3	-	4	1066	c.393G>A	c.(391-393)GGG>GGA	p.G131G	GABRA2_uc010igc.2_Silent_p.G131G|GABRA2_uc011bzc.1_Silent_p.G76G|GABRA2_uc003gxe.2_Silent_p.G131G	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	131	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGATTTTTTCCCATTGTGAA	0.348000													12	63					0	0	1	0	0
TEC	7006	broad.mit.edu	37	4	48169925	48169925	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:48169925C>T	uc003gxz.2	-	7	632	c.541G>A	c.(541-543)GAA>AAA	p.E181K		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	181	SH3.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						ACGATTTCTTCACTATTATCT	0.383000													9	46					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48592750	48592750	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:48592750G>A	uc003gyh.1	-	17	2038	c.1433C>T	c.(1432-1434)CCC>CTC	p.P478L	FRYL_uc003gyk.2_Missense_Mutation_p.P478L	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						ATTTCCTGAGGGAAGAATAAC	0.363000													9	75					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	48996664	48996664	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:48996664G>A	uc003gyv.2	+	5	722	c.540G>A	c.(538-540)AAG>AAA	p.K180K	CWH43_uc011bzl.1_Silent_p.K153K	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	180					GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						CTGAAGAAAAGAAGACTGGTG	0.438000													9	108					0	0	1	0	0
SPATA18	132671	broad.mit.edu	37	4	52942971	52942971	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:52942971C>T	uc003gzl.2	+	7	1063	c.785C>T	c.(784-786)CCT>CTT	p.P262L	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.P230L|SPATA18_uc003gzk.1_Missense_Mutation_p.P262L	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	262	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCTCCCAGCCCTGCCCCTCGC	0.532000													6	65					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181783	57181783	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:57181783C>T	uc003hbk.2	+	8	2506	c.2115C>T	c.(2113-2115)TCC>TCT	p.S705S	KIAA1211_uc010iha.2_Silent_p.S698S|KIAA1211_uc011bzz.1_Silent_p.S615S|KIAA1211_uc003hbm.1_Silent_p.S591S	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	705										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GGTGTGATTCCCGCGGGAACC	0.582000													29	106					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69097044	69097044	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:69097044C>T	uc003hdw.3	-	7	699	c.563G>A	c.(562-564)GGA>GAA	p.G188E		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	188	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						GGAGCTTTTTCCATTCACAAT	0.483000													11	44					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69100213	69100213	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:69100213C>T	uc003hdw.3	-	5	573	c.437G>A	c.(436-438)TGG>TAG	p.W146*		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	146	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AACTGCATTCCAGGATGCCAT	0.333000													9	57					0	0	1	0	0
SULT1B1	27284	broad.mit.edu	37	4	70620463	70620463	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:70620463C>T	uc003hen.2	-	3	500	c.202G>A	c.(202-204)GAA>AAA	p.E68K		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	68					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						TTACATTTTTCAATATCTCCA	0.333000													19	92					0	0	1	0	0
C4orf7	260436	broad.mit.edu	37	4	71096951	71096951	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:71096951G>A	uc003hfd.2	+	2	125	c.40G>A	c.(40-42)GTG>ATG	p.V14M		NM_152997	NP_694542	Q8NFU4	FDSCP_HUMAN	chromosome 4 open reading frame 7 precursor	14						extracellular region				central_nervous_system(1)	1						CATCTTGGCAGTGGCTGTTGG	0.264000													12	55					0	0	1	0	0
C4orf35	85438	broad.mit.edu	37	4	71200859	71200859	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:71200859C>T	uc003hff.2	+	1	189	c.103C>T	c.(103-105)CCC>TCC	p.P35S		NM_033122	NP_149113	Q96KC9	CABS1_HUMAN	testis development protein NYD-SP26	35						flagellum	calcium ion binding				0		all_hematologic(202;0.196)				CAATGCTATTCCCAAATCAGA	0.388000													10	49					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71509557	71509557	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:71509557G>A	uc011caw.1	+	9	2695	c.2414G>A	c.(2413-2415)GGT>GAT	p.G805D		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	805					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			GACCAGAAAGGTAACCAGCCC	0.453000													10	53					0	0	1	0	0
CXCL10	3627	broad.mit.edu	37	4	76943932	76943932	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:76943932T>C	uc003hjl.3	-	2	170	c.100A>G	c.(100-102)AGC>GGC	p.S34G	ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|ART3_uc003hjk.2_Intron	NM_001565	NP_001556	P02778	CXL10_HUMAN	small inducible cytokine B10 precursor	34					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity				0			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTACTAATGCTGATGCAGGTA	0.393000													17	83					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79284704	79284704	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:79284704C>T	uc003hlb.2	+	21	2900	c.2460C>T	c.(2458-2460)CTC>CTT	p.L820L	FRAS1_uc003hkw.2_Silent_p.L820L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	820	FU 9.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CAGCTGATCTCCACAACACTG	0.577000													11	21					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79300958	79300958	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:79300958C>T	uc003hlb.2	+	27	3811	c.3371C>T	c.(3370-3372)TCC>TTC	p.S1124F	FRAS1_uc003hkw.2_Missense_Mutation_p.S1124F	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1123	CSPG 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CTGGATTTTTCCCTCCTGAAT	0.448000													3	26					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80329203	80329203	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:80329203C>T	uc003hlu.2	-	1	170	c.152G>A	c.(151-153)GGA>GAA	p.G51E		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	51					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						TTCCACCCATCCTTCTTTTGG	0.413000													12	111					0	0	1	0	0
C4orf22	255119	broad.mit.edu	37	4	81283950	81283950	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:81283950G>A	uc003hmf.2	+	2	203	c.154G>A	c.(154-156)GGG>AGG	p.G52R	C4orf22_uc010ijp.2_Missense_Mutation_p.G52R	NM_152770	NP_689983	Q6V702	CD022_HUMAN	hypothetical protein LOC255119	52										skin(2)	2						AGGCTACCGAGGGACTGGAGA	0.458000													21	137					0	0	1	0	0
TMEM150C	441027	broad.mit.edu	37	4	83423930	83423930	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:83423930G>A	uc003hmy.1	-	5	263	c.185C>T	c.(184-186)CCT>CTT	p.P62L	TMEM150C_uc011ccj.1_Missense_Mutation_p.P92L	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	62						integral to membrane				ovary(1)	1						GCTTGCAGGAGGATCATCACC	0.383000													4	6					0	0	1	0	0
TMEM150C	441027	broad.mit.edu	37	4	83425749	83425749	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:83425749G>A	uc003hmy.1	-	2	140	c.62C>T	c.(61-63)TCA>TTA	p.S21L	TMEM150C_uc011ccj.1_Missense_Mutation_p.S51L	NM_001080506	NP_001073975	B9EJG8	T150C_HUMAN	transmembrane protein 150C	21	Helical; (Potential).					integral to membrane				ovary(1)	1						CAATCCAGCTGAAGTAAACAA	0.328000													4	24					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90169315	90169315	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:90169315C>T	uc003hsm.1	-	2	2466	c.1947G>A	c.(1945-1947)GTG>GTA	p.V649V		NM_198281	NP_938022	Q6ZVF9	GRIN3_HUMAN	G protein-regulated inducer of neurite outgrowth	649										ovary(3)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		CAGCTGCTGTCACATTTAACT	0.572000													27	70					0	0	1	0	0
TSPAN5	10098	broad.mit.edu	37	4	99408034	99408035	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:99408034_99408035CC>TT	uc003hub.2	-	3	483_484	c.133_134GG>AA	c.(133-135)GGA>AAA	p.G45K	TSPAN5_uc011cdz.1_5'UTR	NM_005723	NP_005714	P62079	TSN5_HUMAN	transmembrane 4 superfamily member 9	45	Extracellular (Potential).					integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(123;1.89e-07)		GGACAGAACTCCCTGGGAGCAG	0.480000													14	123					0	0	1	0	0
ADH1A	124	broad.mit.edu	37	4	100208142	100208142	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:100208142C>T	uc003hur.1	-	3	195	c.124G>A	c.(124-126)GTG>ATG	p.V42M	uc003hum.1_RNA|ADH1A_uc011ceg.1_Missense_Mutation_p.V42M|ADH1A_uc010ilf.1_5'Flank|ADH1A_uc010ilg.1_Missense_Mutation_p.V42M	NM_000667	NP_000658	P07327	ADH1A_HUMAN	class I alcohol dehydrogenase, alpha subunit	42					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CCTACAGCCACCATCTACAGA	0.453000													13	91					0	0	1	0	0
RRH	10692	broad.mit.edu	37	4	110763636	110763636	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:110763636C>T	uc003hzv.2	+	6	766	c.732C>T	c.(730-732)ATC>ATT	p.I244I		NM_006583	NP_006574	O14718	OPSX_HUMAN	peropsin	244	Helical; Name=6; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		TGTCTGTGATCATGATCTGCA	0.388000													7	115					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114824382	114824382	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:114824382C>T	uc003ibq.1	-	2	1736	c.848G>A	c.(847-849)CGA>CAA	p.R283Q	ARSJ_uc010imu.1_Missense_Mutation_p.R283Q|ARSJ_uc010imv.1_Missense_Mutation_p.R111Q	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	283						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		GATAATGGATCGGTAGTGTTC	0.413000													26	73					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115585262	115585262	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:115585262C>T	uc003ibs.2	+	3	1456	c.934C>T	c.(934-936)CTG>TTG	p.L312L	UGT8_uc003ibt.2_Silent_p.L312L|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	312					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		GGCAGGAGCTCTGGGGAGATT	0.413000													19	48					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997456	115997456	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:115997456G>A	uc003ibu.2	-	2	1416	c.737C>T	c.(736-738)TCC>TTC	p.S246F	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	246	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GCTAGACAAGGATGACAGGGA	0.428000													19	79					0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115997949	115997949	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:115997949G>A	uc003ibu.2	-	2	923	c.244C>T	c.(244-246)CTC>TTC	p.L82F	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	82	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCCACGAAGAGAAGGACAGTA	0.438000													6	68					0	0	1	0	0
SYNPO2	171024	broad.mit.edu	37	4	119810202	119810202	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:119810202G>A	uc003icm.3	+	1	207	c.11G>A	c.(10-12)GGG>GAG	p.G4E	SYNPO2_uc010ina.2_Missense_Mutation_p.G4E|SYNPO2_uc010inb.2_Missense_Mutation_p.G4E|SYNPO2_uc011cgh.1_Missense_Mutation_p.G4E	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	4						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						ATGGGCACAGGGGATTTTATC	0.547000													17	76					0	0	1	0	0
FABP2	2169	broad.mit.edu	37	4	120241838	120241838	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:120241838C>T	uc003icw.2	-	2	286	c.227G>A	c.(226-228)GGA>GAA	p.G76E		NM_000134	NP_000125	P12104	FABPI_HUMAN	intestinal fatty acid binding protein 2	76							fatty acid binding			ovary(1)	1						GAGTTCAGTTCCGTCTGCTAG	0.318000													7	37					0	0	1	0	0
IL21	59067	broad.mit.edu	37	4	123542087	123542087	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:123542087G>A	uc003ies.2	-	1	125	c.80C>T	c.(79-81)TCA>TTA	p.S27L	uc003iet.2_RNA|IL21_uc010int.2_Missense_Mutation_p.S20L	NM_021803	NP_068575	Q9HBE4	IL21_HUMAN	interleukin 21	20					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding				0						TTGGGAGCTTGATTTGTGGAC	0.418000													12	48					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126371365	126371365	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:126371365G>A	uc003ifj.3	+	9	9194	c.9194G>A	c.(9193-9195)GGA>GAA	p.G3065E	FAT4_uc011cgp.1_Missense_Mutation_p.G1363E|FAT4_uc003ifi.1_Missense_Mutation_p.G543E	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3065	Extracellular (Potential).|Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AAGGATAAGGGAAACCCTCCA	0.423000													4	26					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138442315	138442315	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:138442315G>A	uc003ihe.3	-	4	3663	c.3276C>T	c.(3274-3276)ATC>ATT	p.I1092I	PCDH18_uc003ihf.3_Silent_p.I1084I|PCDH18_uc011cgz.1_Silent_p.I303I|PCDH18_uc003ihg.3_Silent_p.I871I|PCDH18_uc011cha.1_Silent_p.I272I	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	1092	Interaction with DAB1 (By similarity).|Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AATTTTCAGGGATCTCCTCCA	0.483000													3	33					0	0	1	0	0
TTC29	83894	broad.mit.edu	37	4	147830293	147830293	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:147830293C>T	uc003ikw.3	-	5	512	c.285G>A	c.(283-285)AGG>AGA	p.R95R	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Silent_p.R121R|TTC29_uc010ipd.1_Silent_p.R95R	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	95							binding				0	all_hematologic(180;0.151)					TCGCAGCCTCCCTCAGGGCAT	0.547000													7	47					0	0	1	0	0
TTC29	83894	broad.mit.edu	37	4	147830331	147830331	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:147830331C>T	uc003ikw.3	-	5	474	c.247G>A	c.(247-249)GAG>AAG	p.E83K	TTC29_uc010ipc.2_RNA|TTC29_uc003ikx.3_Missense_Mutation_p.E109K|TTC29_uc010ipd.1_Missense_Mutation_p.E83K	NM_031956	NP_114162	Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	83							binding				0	all_hematologic(180;0.151)					GCGAAGAGCTCGGTGAAGGAC	0.517000													6	26					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154626057	154626057	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:154626057C>T	uc003inq.2	+	3	2217	c.1998C>T	c.(1996-1998)TTC>TTT	p.F666F	TLR2_uc003inr.2_Silent_p.F666F|TLR2_uc003ins.2_Silent_p.F666F	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	666	TIR.|Cytoplasmic (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				TGGAGAACTTCAATCCCCCCT	0.468000													6	61					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155157181	155157181	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:155157181C>T	uc003inw.2	-	25	7258	c.7258G>A	c.(7258-7260)GAA>AAA	p.E2420K		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2420	Cadherin 21.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGCTCAAATTCATCTATCCCT	0.428000													13	49					0	0	1	0	0
FGB	2244	broad.mit.edu	37	4	155487105	155487105	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:155487105G>A	uc003ioa.3	+	2	299	c.260G>A	c.(259-261)AGA>AAA	p.R87K	FGB_uc010ipu.1_RNA|FGB_uc003iob.3_Missense_Mutation_p.R84K|FGB_uc010ipv.2_Intron|FGB_uc010ipw.2_Missense_Mutation_p.R84K|FGB_uc003ioc.3_Intron	NM_005141	NP_005132	P02675	FIBB_HUMAN	fibrinogen, beta chain preproprotein	87			Missing (in New York-1).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen|soluble fraction	chaperone binding|eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	AAAGTAGAAAGAAAAGCCCCT	0.582000													6	29					0	0	1	0	0
NPY2R	4887	broad.mit.edu	37	4	156136186	156136186	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:156136186C>T	uc003ioq.2	+	2	1590	c.1095C>T	c.(1093-1095)GTC>GTT	p.V365V	NPY2R_uc003ior.2_Silent_p.V365V	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	365	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				ACCTGGAGGTCAGAAAGAACA	0.488000													7	49					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164393411	164393411	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:164393411C>T	uc003iqp.3	-	1	1637	c.1476G>A	c.(1474-1476)GAG>GAA	p.E492E		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	492						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CCTGGCCAATCTCAAAATTTT	0.463000													15	108					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	167012436	167012436	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:167012436C>T	uc003irh.1	+	19	3246	c.2599C>T	c.(2599-2601)CGG>TGG	p.R867W	TLL1_uc011cjn.1_Missense_Mutation_p.R890W|TLL1_uc011cjo.1_Missense_Mutation_p.R691W	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	867	CUB 4.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		AATGTTTGTTCGGTTTGTTTC	0.403000													6	36					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167675732	167675732	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:167675732G>A	uc003iri.1	-	9	1008	c.867C>T	c.(865-867)TTC>TTT	p.F289F	SPOCK3_uc011cjp.1_Silent_p.F246F|SPOCK3_uc011cjq.1_Silent_p.F298F|SPOCK3_uc011cjr.1_Silent_p.F169F|SPOCK3_uc003irj.1_Silent_p.F286F|SPOCK3_uc011cjs.1_Silent_p.F238F|SPOCK3_uc011cjt.1_Silent_p.F197F|SPOCK3_uc011cju.1_Silent_p.F182F|SPOCK3_uc011cjv.1_Silent_p.F191F|SPOCK3_uc003irk.3_Silent_p.F286F	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	289					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CACAAGAATTGAAGAATGCCT	0.398000													11	43					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169143005	169143005	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:169143005G>A	uc003irp.2	-	36	5144	c.4852C>T	c.(4852-4854)CGC>TGC	p.R1618C	DDX60_uc003iro.2_Missense_Mutation_p.R89C	NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1618							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		GCCTGAGAGCGATTGACACCG	0.363000													6	33					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169374318	169374318	+	Missense_Mutation	SNP	A	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:169374318A>T	uc003irq.3	-	8	1174	c.953T>A	c.(952-954)ATC>AAC	p.I318N	DDX60L_uc003irr.1_Missense_Mutation_p.I318N|DDX60L_uc003irs.1_Missense_Mutation_p.I45N	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	318							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		AGAGCATGTGATGACTCGAGA	0.413000													4	54					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169632963	169632963	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:169632963G>A	uc011cjx.1	+	10	2064	c.1853G>A	c.(1852-1854)GGA>GAA	p.G618E	PALLD_uc003iru.2_Missense_Mutation_p.G618E|PALLD_uc003irv.2_Missense_Mutation_p.G236E	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	618					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CCCAGCCGTGGAGTAAATGGA	0.517000									Pancreatic_Cancer_Familial_Clustering_of				7	44					0	0	1	0	0
AADAT	51166	broad.mit.edu	37	4	171008297	171008297	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:171008297G>A	uc003isr.2	-	3	681	c.339C>T	c.(337-339)GTC>GTT	p.V113V	AADAT_uc003iss.2_Silent_p.V113V|AADAT_uc003ist.2_Silent_p.V117V	NM_016228	NP_057312	Q8N5Z0	AADAT_HUMAN	kynurenine aminotransferase II	113					2-oxoglutarate metabolic process|biosynthetic process|glutamate metabolic process|lysine catabolic process	mitochondrial matrix	2-aminoadipate transaminase activity|kynurenine-oxoglutarate transaminase activity|protein homodimerization activity				0		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0355)|LUSC - Lung squamous cell carcinoma(193;0.118)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	TGCCAGATGTGACACATAGAT	0.408000													5	131					0	0	1	0	0
MORF4	10934	broad.mit.edu	37	4	174537113	174537113	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:174537113G>A	uc011cke.1	-	1	682	c.682C>T	c.(682-684)CCT>TCT	p.P228S		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TGGTACTCAGGAAGAGCCACT	0.408000													5	36					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177052800	177052800	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:177052800C>T	uc003iuj.2	+	8	1237	c.1081C>T	c.(1081-1083)CCT>TCT	p.P361S	WDR17_uc003iuk.2_Missense_Mutation_p.P337S|WDR17_uc003ium.3_Missense_Mutation_p.P337S|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	361										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ATTTTCTCTTCCTCCTGGTCA	0.403000													23	217					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184190176	184190176	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:184190176C>T	uc010irx.2	+	15	2442	c.2260C>T	c.(2260-2262)CGC>TGC	p.R754C	WWC2_uc003ivk.3_Missense_Mutation_p.R549C|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Missense_Mutation_p.R436C|WWC2_uc003ivn.3_Missense_Mutation_p.R269C|WWC2_uc010irz.2_Missense_Mutation_p.R71C	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	754	C2.									ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		CTGTCTGTTTCGCACAAAAGT	0.398000													19	183					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185038131	185038131	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:185038131C>T	uc003iwc.2	-	5	875	c.733G>A	c.(733-735)GAC>AAC	p.D245N		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	245	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		CAGAAAATGTCGGTCATTCCG	0.532000													11	42					0	0	1	0	0
ENPP6	133121	broad.mit.edu	37	4	185074732	185074732	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:185074732C>T	uc003iwc.2	-	2	538	c.396G>A	c.(394-396)AGG>AGA	p.R132R		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	132	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		TGTAGACCTTCCTTTTGGCCT	0.473000													5	64					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189060749	189060749	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr4:189060749G>A	uc003izm.1	+	1	152	c.37G>A	c.(37-39)GAA>AAA	p.E13K		NM_178556	NP_848651	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	13					multicellular organismal development		ligase activity|zinc ion binding			ovary(1)|pancreas(1)|breast(1)|skin(1)	4		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCTCAGGGAGGAACTCACCTG	0.522000													34	139					0	0	1	0	0
LRRC14B	389257	broad.mit.edu	37	5	194890	194890	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:194890T>C	uc003jal.1	+	2	995	c.967T>C	c.(967-969)TTC>CTC	p.F323L		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	323										skin(1)	1						GGACATGGCCTTCTTGGCAGA	0.627000													5	32					0	0	1	0	0
SLC6A3	6531	broad.mit.edu	37	5	1420810	1420810	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:1420810C>T	uc003jck.2	-	6	922	c.801G>A	c.(799-801)TGG>TGA	p.W267*		NM_001044	NP_001035	Q01959	SC6A3_HUMAN	solute carrier family 6 (neurotransmitter	267	Helical; Name=5; (Potential).				cell death|neurotransmitter biosynthetic process	axon|cytoplasm|integral to plasma membrane|neuronal cell body				ovary(3)|breast(2)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(19;0.00928)|all cancers(22;0.0262)		Amphetamine(DB00182)|Benztropine(DB00245)|Bupropion(DB01156)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dextroamphetamine(DB01576)|Diethylpropion(DB00937)|Duloxetine(DB00476)|Fencamfamine(DB01463)|Mazindol(DB00579)|Methylphenidate(DB00422)|Modafinil(DB00745)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Procaine(DB00721)	TGGCTGTGATCCATACCACCT	0.632000													27	69					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11111118	11111118	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:11111118G>A	uc003jfa.1	-	14	2460	c.2315C>T	c.(2314-2316)TCG>TTG	p.S772L	CTNND2_uc010itt.2_Missense_Mutation_p.S681L|CTNND2_uc011cmy.1_Missense_Mutation_p.S435L|CTNND2_uc011cmz.1_Missense_Mutation_p.S339L|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S339L	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	772	ARM 6.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CAGCCGGTACGAGAGGTTCCT	0.537000													15	92					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13735385	13735385	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:13735385G>A	uc003jfd.2	-	68	11658	c.11616C>T	c.(11614-11616)ATC>ATT	p.I3872I	DNAH5_uc003jfc.2_Silent_p.I40I	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3872					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCATGTGCTCGATGATATTAG	0.443000									Kartagener_syndrome				6	31					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13753355	13753355	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:13753355C>T	uc003jfd.2	-	63	10901	c.10859G>A	c.(10858-10860)CGA>CAA	p.R3620Q	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3620	AAA 5 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					GAGTTCATTTCGGCTTTCTTT	0.333000									Kartagener_syndrome				7	30					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13771045	13771045	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:13771045C>T	uc003jfd.2	-	56	9460	c.9418G>A	c.(9418-9420)GAA>AAA	p.E3140K	DNAH5_uc003jfc.2_5'Flank	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3140	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TTCTTGATTTCCAAACTGCAG	0.423000									Kartagener_syndrome				8	46					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13850880	13850880	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:13850880G>A	uc003jfd.2	-	31	5037	c.4995C>T	c.(4993-4995)ATC>ATT	p.I1665I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1665	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCCGAGTCATGATCTTCACCC	0.463000									Kartagener_syndrome				16	80					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13900363	13900363	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:13900363G>A	uc003jfd.2	-	15	2253	c.2211C>T	c.(2209-2211)TCC>TCT	p.S737S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	737	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCTGGAAGAGGGAAGTTGCCA	0.403000									Kartagener_syndrome				7	63					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13923485	13923485	+	Silent	SNP	G	A	A	rs145920072	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:13923485G>A	uc003jfd.2	-	4	384	c.342C>T	c.(340-342)TTC>TTT	p.F114F	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	114	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCTCGGTCACGAACACCTTAG	0.433000									Kartagener_syndrome				12	74					0	0	1	0	0
ANKH	56172	broad.mit.edu	37	5	14756009	14756009	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:14756009G>A	uc003jfm.3	-	4	808	c.477C>T	c.(475-477)TTC>TTT	p.F159F		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	159	Helical; (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						ATCCCACCAGGAAACTGTATT	0.453000													9	57					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16701236	16701236	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:16701236C>T	uc003jft.3	-	25	3736	c.3268G>A	c.(3268-3270)GAC>AAC	p.D1090N	MYO10_uc011cnc.1_5'Flank|MYO10_uc011cnd.1_Missense_Mutation_p.D447N|MYO10_uc011cne.1_Missense_Mutation_p.D447N|MYO10_uc010itx.2_Missense_Mutation_p.D713N	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1090					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TGGTCGTAGTCGTAGTCGCCG	0.632000													5	13					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19520868	19520868	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:19520868G>A	uc003jgc.2	-	9	1787	c.1410C>T	c.(1408-1410)AGC>AGT	p.S470S	CDH18_uc003jgd.2_Silent_p.S470S|CDH18_uc011cnm.1_Silent_p.S470S	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	470	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTGTGACATGGCTCAGCAAAT	0.383000													34	140					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24492984	24492984	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:24492984C>T	uc003jgr.1	-	10	1898	c.1566G>A	c.(1564-1566)CAG>CAA	p.Q522Q	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	522	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AAAAAAATTTCTGTCCACCTA	0.323000										HNSCC(23;0.051)			34	164					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31267601	31267601	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:31267601C>T	uc003jhe.1	+	2	347	c.21C>T	c.(19-21)TTC>TTT	p.F7F	CDH6_uc003jhd.1_Silent_p.F7F	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	7					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						ACCGCTACTTCTTGCTGCTCT	0.537000													17	77					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32088003	32088003	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:32088003G>A	uc003jhl.2	+	20	4837	c.4449G>A	c.(4447-4449)CCG>CCA	p.P1483P	PDZD2_uc003jhm.2_Silent_p.P1483P	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1483					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CCTCCTCCCCGAGGAGGGCCT	0.642000													5	23					0	0	1	0	0
Unknown	0	broad.mit.edu	37	5	33162465	33162465	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:33162465G>A	uc003jhx.2	+	1		c.200G>A								full-length cDNA clone CS0DI021YI22 of Placenta Cot 25-normalized of Homo sapiens (human).																		CCTGAGGTTGGACGTGGGGGA	0.522000													6	58					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576790	33576790	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:33576790G>A	uc003jia.1	-	19	3504	c.3341C>T	c.(3340-3342)ACC>ATC	p.T1114I	ADAMTS12_uc010iuq.1_Missense_Mutation_p.T1029I	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1114	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCCCTCCGAGGTAGGACCAGT	0.493000										HNSCC(64;0.19)			17	65					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049429	36049429	+	Silent	SNP	C	T	T	rs147027144		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:36049429C>T	uc003jjz.1	-	4	498	c.405G>A	c.(403-405)AAG>AAA	p.K135K	UGT3A2_uc011cos.1_Silent_p.K101K|UGT3A2_uc011cot.1_Intron	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	135	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity	p.K135K(1)		ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTTCTCATTCTTTAAGGAAT	0.363000													5	32					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39341279	39341279	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:39341279C>T	uc003jlv.3	-	4	534	c.445G>A	c.(445-447)GAG>AAG	p.E149K		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	149	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AGCTCAGACTCTTCTACCACT	0.463000													29	108					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40972562	40972562	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:40972562C>T	uc003jmh.2	+	15	2054	c.1940C>T	c.(1939-1941)CCT>CTT	p.P647L	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	647	Sushi 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CCCCAAAAACCTTTCTACACA	0.453000													7	44					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41143032	41143032	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:41143032C>T	uc003jmk.2	-	18	2910	c.2700G>A	c.(2698-2700)ATG>ATA	p.M900I	C6_uc003jml.1_Missense_Mutation_p.M900I	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	900	Complement control factor I module 2.|C5b-binding domain.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTGATGATCCCATTTTGACAC	0.443000													8	37					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181595	41181595	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:41181595C>T	uc003jmk.2	-	7	1003	c.793G>A	c.(793-795)GAA>AAA	p.E265K	C6_uc003jml.1_Missense_Mutation_p.E265K	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	265	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TGTTGATTTTCATTGTGTCCA	0.343000													3	31					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41850282	41850282	+	Splice_Site	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:41850282C>T	uc003jmn.2	-	5	746	c.415_splice	c.e5-1	p.G139_splice		NM_000436	NP_000427	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1 precursor						cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			ovary(2)|large_intestine(1)	3					Succinic acid(DB00139)	CAAGTGTGCCCTGCAAGTGAG	0.502000													3	34					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49699201	49699201	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:49699201C>T	uc003jom.2	-	6	937	c.688G>A	c.(688-690)GAA>AAA	p.E230K	EMB_uc010ivq.2_Missense_Mutation_p.E24K|EMB_uc003jol.2_Missense_Mutation_p.E161K|EMB_uc011cpy.1_Missense_Mutation_p.E180K|EMB_uc010ivr.2_Missense_Mutation_p.E176K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	230	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TCCCCATCTTCCTCCAAAAGT	0.423000													7	26					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49706744	49706744	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:49706744C>T	uc003jom.2	-	4	688	c.439G>A	c.(439-441)GAA>AAA	p.E147K	EMB_uc003jol.2_Missense_Mutation_p.E78K|EMB_uc011cpy.1_Missense_Mutation_p.E97K|EMB_uc010ivr.2_Missense_Mutation_p.E93K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	147	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TGTTCCTTTTCCTCTCGAAAG	0.308000													6	26					0	0	1	0	0
GZMK	3003	broad.mit.edu	37	5	54326371	54326371	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:54326371G>A	uc003jpl.1	+	3	366	c.322G>A	c.(322-324)GTT>ATT	p.V108I		NM_002104	NP_002095	P49863	GRAK_HUMAN	granzyme K precursor	108	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				ATTCTCAAGAGTTACATCAGA	0.398000													19	92					0	0	1	0	0
DDX4	54514	broad.mit.edu	37	5	55088501	55088501	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:55088501G>A	uc003jqg.3	+	17	1409	c.1335G>A	c.(1333-1335)TTG>TTA	p.L445L	DDX4_uc010ivz.2_Silent_p.L425L|DDX4_uc003jqh.3_Silent_p.L411L|DDX4_uc003jqj.2_Silent_p.L296L	NM_001136034	NP_001129506	Q9NQI0	DDX4_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 isoform	445	Helicase ATP-binding.				multicellular organismal development|sperm motility	perinuclear region of cytoplasm|pi-body|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|skin(1)	2		Lung NSC(810;6.93e-05)|all_neural(839;0.00409)|Prostate(74;0.0107)|Breast(144;0.0544)|Ovarian(174;0.223)				ACTTAGTTTTGGATGAAGCTG	0.343000													8	57					0	0	1	0	0
CENPK	64105	broad.mit.edu	37	5	64814402	64814402	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:64814402G>C	uc003jts.2	-	11	922	c.710C>G	c.(709-711)TCC>TGC	p.S237C	CENPK_uc003jtt.2_Missense_Mutation_p.S207C|CENPK_uc003jtu.2_Missense_Mutation_p.S237C	NM_022145	NP_071428	Q9BS16	CENPK_HUMAN	SoxLZ/Sox6 leucine zipper binding protein	237					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm					0		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00466)		TGGCCAAAAGGAATCACTAAT	0.348000													13	51					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79351631	79351631	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:79351631G>A	uc003kgh.2	+	4	639	c.316G>A	c.(316-318)GAT>AAT	p.D106N		NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	106	TSP N-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CCTGAAGAACGATGGGAAGGT	0.552000													54	310					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79617099	79617099	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:79617099G>A	uc003kgn.2	+	1	1310	c.1065G>A	c.(1063-1065)CAG>CAA	p.Q355Q	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AGCCAATTCAGATAAACTATA	0.383000													11	63					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	80057441	80057441	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:80057441C>T	uc003kgz.2	+	13	2093	c.1840C>T	c.(1840-1842)CAT>TAT	p.H614Y		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	614					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GATAGAAAATCATCTACGTAA	0.388000								MMR					15	60					0	0	1	0	0
ZCCHC9	84240	broad.mit.edu	37	5	80604378	80604378	+	Splice_Site	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:80604378A>G	uc003khj.2	+	3	518	c.385_splice	c.e3-2	p.V129_splice	RNU5E_uc011cto.1_Intron|ZCCHC9_uc003khk.3_Splice_Site_p.V129_splice|ZCCHC9_uc003khi.2_Splice_Site_p.V129_splice	NM_001131035	NP_001124507	Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9								nucleic acid binding|zinc ion binding			ovary(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		TTGTTTTCCTAGGTGTGTTTC	0.393000													20	88					0	0	1	0	0
XRCC4	7518	broad.mit.edu	37	5	82400778	82400778	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:82400778C>G	uc003kib.2	+	2	168	c.40C>G	c.(40-42)CCC>GCC	p.P14A	XRCC4_uc003kia.1_Missense_Mutation_p.P14A|XRCC4_uc003kid.2_Missense_Mutation_p.P14A|XRCC4_uc003kic.2_Missense_Mutation_p.P14A|XRCC4_uc003kie.2_Missense_Mutation_p.P14A|XRCC4_uc003kif.1_Missense_Mutation_p.P14A	NM_022406	NP_071801	Q13426	XRCC4_HUMAN	X-ray repair cross complementing protein 4	14					DNA ligation involved in DNA repair|double-strand break repair via nonhomologous end joining|initiation of viral infection|positive regulation of ligase activity|provirus integration|response to X-ray	cytosol|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|nucleoplasm	DNA binding|protein C-terminus binding			skin(3)	3		Lung NSC(167;0.00132)|all_lung(232;0.00154)|Ovarian(174;0.034)		OV - Ovarian serous cystadenocarcinoma(54;1.44e-38)|Epithelial(54;3.72e-33)|all cancers(79;9.22e-28)		TGTTTCTGAACCCAGTATAAC	0.343000								NHEJ					11	69					0	0	1	0	0
ERAP2	64167	broad.mit.edu	37	5	96232463	96232463	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:96232463G>A	uc003kmq.2	+	9	2109	c.1399G>A	c.(1399-1401)GAT>AAT	p.D467N	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.D467N|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.D416N|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	467	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TATGCTCAAGGATTTTCTGGG	0.328000													11	51					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96315306	96315306	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:96315306C>T	uc003kmv.1	+	2	998	c.484C>T	c.(484-486)CCA>TCA	p.P162S	LNPEP_uc003kmw.1_Missense_Mutation_p.P148S	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	162	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		GAAATTGTTTCCATGGGCACA	0.463000													10	60					0	0	1	0	0
LNPEP	4012	broad.mit.edu	37	5	96358092	96358092	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:96358092C>T	uc003kmv.1	+	14	2979	c.2465C>T	c.(2464-2466)GCC>GTC	p.A822V	LNPEP_uc003kmw.1_Missense_Mutation_p.A808V	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	822	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		CTTCGGTCAGCCCTGCTAGAG	0.453000													13	30					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100147705	100147705	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:100147705C>T	uc003knk.2	-	5	1254	c.926G>A	c.(925-927)GGA>GAA	p.G309E		NM_005668	NP_005659	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide	309	Lumenal (Potential).				axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			large_intestine(1)|central_nervous_system(1)	2		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		GACCGCTTTTCCATTTAAATC	0.368000													10	27					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100231369	100231369	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:100231369G>A	uc003knk.2	-	2	562	c.234C>T	c.(232-234)GTC>GTT	p.V78V	ST8SIA4_uc003knl.2_Silent_p.V78V	NM_005668	NP_005659	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide	78	Lumenal (Potential).				axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			large_intestine(1)|central_nervous_system(1)	2		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		TTATCTCTAGGACCAAAGAGG	0.378000													13	75					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110710584	110710584	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:110710584C>T	uc011cvj.1	+	4	376	c.277C>T	c.(277-279)CTT>TTT	p.L93F	CAMK4_uc003kpf.2_Missense_Mutation_p.L93F|CAMK4_uc010jbv.2_Intron	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	93	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		GATAGGAGTTCTTCTTCGCCT	0.383000													6	28					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111595675	111595675	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:111595675C>T	uc003kpv.1	-	8	918	c.644G>A	c.(643-645)GGA>GAA	p.G215E		NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	215	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		CTTGTTTTCTCCCTGCAAAAA	0.323000													11	42					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111643179	111643179	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:111643179C>T	uc003kpv.1	-	2	382	c.108G>A	c.(106-108)ACG>ACA	p.T36T	EPB41L4A_uc003kpw.1_Silent_p.T36T	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	36	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		CGGAACCTTTCGTTGACTTCT	0.383000													9	25					0	0	1	0	0
AQPEP	206338	broad.mit.edu	37	5	115335570	115335570	+	Missense_Mutation	SNP	G	A	A	rs140991083		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:115335570G>A	uc003kro.2	+	7	1650	c.1486G>A	c.(1486-1488)GAA>AAA	p.E496K	AQPEP_uc003krp.2_RNA|AQPEP_uc003krq.2_RNA|AQPEP_uc003krr.2_RNA|AQPEP_uc003krs.2_RNA	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	496	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding	p.E496K(1)			0						TGAAATACAGGAACTCTTTGA	0.358000													13	46					0	0	1	0	0
HSD17B4	3295	broad.mit.edu	37	5	118860945	118860945	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:118860945C>T	uc003ksj.2	+	18	1661	c.1538C>T	c.(1537-1539)CCC>CTC	p.P513L	HSD17B4_uc011cwg.1_Missense_Mutation_p.P489L|HSD17B4_uc011cwh.1_Missense_Mutation_p.P495L|HSD17B4_uc011cwi.1_Missense_Mutation_p.P538L|HSD17B4_uc003ksk.3_Missense_Mutation_p.P366L|HSD17B4_uc011cwj.1_Missense_Mutation_p.P366L|HSD17B4_uc010jcn.1_Missense_Mutation_p.P251L|HSD17B4_uc010jco.1_5'UTR	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	513	MaoC-like.|(3R)-3-hydroxydecanoyl-CoA binding (By similarity).|Enoyl-CoA hydratase 2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GACTGGAATCCCTTACACATT	0.328000													8	30					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127730909	127730909	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:127730909G>A	uc003kuu.2	-	9	1576	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	FBN2_uc003kuv.2_Silent_p.L346L	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	379	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTCTCCCCGGGAGCTCTTGTG	0.532000													11	40					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128862102	128862102	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:128862102C>T	uc003kvb.1	+	4	1021	c.1021C>T	c.(1021-1023)CAT>TAT	p.H341Y	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	341	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GGTTTCCTATCATGGAGCAGA	0.388000													16	68					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128984583	128984583	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:128984583G>A	uc003kvb.1	+	13	2078	c.2078G>A	c.(2077-2079)AGA>AAA	p.R693K	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	693	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCTGGATTCAGAGACTGGCAA	0.448000													27	130					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129240643	129240644	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:129240643_129240644GG>AA	uc003kvd.2	+	1	121_122	c.121_122GG>AA	c.(121-123)GGC>AAC	p.G41N		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	41	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GAAGAGACGTGGCTCCAGCCTC	0.713000													4	8					0	0	1	0	0
CHSY3	337876	broad.mit.edu	37	5	129520869	129520869	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:129520869G>A	uc003kvd.2	+	3	2034	c.2034G>A	c.(2032-2034)CAG>CAA	p.Q678Q		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	678	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		AAGGGTACCAGAACAAGTACC	0.443000													11	29					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130791677	130791677	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:130791677G>A	uc003kvn.1	-	20	3099	c.2893C>T	c.(2893-2895)CTC>TTC	p.L965F	RAPGEF6_uc003kvp.1_Missense_Mutation_p.L1015F|RAPGEF6_uc003kvo.1_Missense_Mutation_p.L970F|RAPGEF6_uc010jdi.1_Missense_Mutation_p.L965F|RAPGEF6_uc010jdj.1_Missense_Mutation_p.L965F|RAPGEF6_uc003kvq.2_Missense_Mutation_p.L682F|RAPGEF6_uc003kvr.2_Missense_Mutation_p.L965F|RAPGEF6_uc011cxe.1_RNA	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	965	Ras-GEF.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		GTTCCTCTGAGTCTTGCTACA	0.398000													7	50					0	0	1	0	0
IL3	3562	broad.mit.edu	37	5	131398014	131398014	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:131398014C>T	uc003kwe.1	+	3	267	c.214C>T	c.(214-216)CTT>TTT	p.L72F		NM_000588	NP_000579	P08700	IL3_HUMAN	interleukin 3 precursor	72					cell-cell signaling|immune response|nervous system development|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of survival gene product expression|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|growth factor activity|interleukin-3 receptor binding			ovary(2)|central_nervous_system(1)	3		all_cancers(142;7.42e-12)|Lung NSC(810;4.25e-07)|all_lung(232;1.93e-06)|Prostate(281;0.00741)|Breast(839;0.0544)|Lung SC(612;0.122)|Ovarian(839;0.223)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	GBM - Glioblastoma multiforme(465;0.0161)|Lung(113;0.105)	Amlexanox(DB01025)	GGAAAATAACCTTCGAAGGCC	0.488000													69	357					0	0	1	0	0
P4HA2	8974	broad.mit.edu	37	5	131539494	131539494	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:131539494G>A	uc003kwh.2	-	10	1762	c.1198C>T	c.(1198-1200)CGT>TGT	p.R400C	P4HA2_uc003kwg.2_Missense_Mutation_p.R400C|P4HA2_uc003kwi.2_Missense_Mutation_p.R400C|P4HA2_uc003kwk.2_Missense_Mutation_p.R400C|P4HA2_uc003kwl.2_Missense_Mutation_p.R400C|P4HA2_uc003kwj.2_Missense_Mutation_p.R400C	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	400						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	TGCATCCGACGATTTACTCGG	0.483000													4	38					0	0	1	0	0
GFRA3	2676	broad.mit.edu	37	5	137600047	137600047	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:137600047C>T	uc003lcn.2	-	2	422	c.282G>A	c.(280-282)AGG>AGA	p.R94R	GFRA3_uc003lco.2_Silent_p.R94R	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	94					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GAGAGCTGTTCCTGAGTTGCT	0.597000													19	71					0	0	1	0	0
MATR3	9782	broad.mit.edu	37	5	138651799	138651799	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:138651799C>T	uc003ldu.2	+	8	1478	c.1051C>T	c.(1051-1053)CCA>TCA	p.P351S	MATR3_uc010jfb.2_Missense_Mutation_p.P351S|MATR3_uc003ldt.2_Missense_Mutation_p.P13S|MATR3_uc003ldw.2_Missense_Mutation_p.P351S|MATR3_uc003ldx.2_Missense_Mutation_p.P351S|MATR3_uc010jfc.2_Missense_Mutation_p.P351S|MATR3_uc003ldy.2_Missense_Mutation_p.P28S|MATR3_uc011czb.1_Missense_Mutation_p.P63S|MATR3_uc003ldz.2_Missense_Mutation_p.P351S|MATR3_uc003lea.2_Missense_Mutation_p.P351S|MATR3_uc003leb.2_Missense_Mutation_p.P13S|MATR3_uc003lec.2_Missense_Mutation_p.P28S	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	351						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTCTACAAATCCAGCACCAGG	0.388000													15	114					0	0	1	0	0
IK	3550	broad.mit.edu	37	5	140038606	140038606	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140038606G>A	uc003lgq.2	+	12	1143	c.1033G>A	c.(1033-1035)GAG>AAG	p.E345K		NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	345	2.|17 X 2 AA tandem repeats of R-[ED].				cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			tcgggaacgggagcgtgatcg	0.149000													8	62					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166202	140166202	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140166202C>T	uc003lhb.2	+	1	327	c.327C>T	c.(325-327)ATC>ATT	p.I109I	PCDHA1_uc003lha.2_Silent_p.I109I|PCDHA1_uc003lgz.2_Silent_p.I109I	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	109	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGTTGATCGCCGACAGGC	0.498000													25	150					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140183128	140183128	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140183128C>T	uc003lhf.2	+	1	2346	c.2346C>T	c.(2344-2346)AGC>AGT	p.S782S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.S782S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	782	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCCAATTAGCCGGGATAGAG	0.473000													18	103					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208028	140208028	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140208028C>T	uc003lho.2	+	1	379	c.352C>T	c.(352-354)CAT>TAT	p.H118Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Missense_Mutation_p.H118Y|PCDHA6_uc011dab.1_Missense_Mutation_p.H118Y	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	118	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGGTTTTCCATGTGGACGT	0.572000													44	229					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222919	140222919	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140222919G>A	uc003lhs.2	+	1	2013	c.2013G>A	c.(2011-2013)GAG>GAA	p.E671E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.E671E	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	671	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGGTGGAGAGCGGCCAGG	0.632000													22	99					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236523	140236523	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140236523G>A	uc003lhx.2	+	1	890	c.890G>A	c.(889-891)AGG>AAG	p.R297K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.R297K|PCDHA10_uc011dad.1_Missense_Mutation_p.R297K	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	297	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAAACGAAAGGACGGGAGAA	0.368000													11	46					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250917	140250917	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140250917G>A	uc003lia.2	+	1	3087	c.2229G>A	c.(2227-2229)GCG>GCA	p.A743A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Silent_p.A743A	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	743	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCCCGCGCGGTGGGGAGCT	0.677000													14	53					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516566	140516566	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140516566C>T	uc003liq.2	+	1	1767	c.1550C>T	c.(1549-1551)TCG>TTG	p.S517L		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	517	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCTCAGGTCGCTGGACTAC	0.697000													30	162					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140529985	140529985	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140529985G>A	uc003lir.2	+	1	147	c.147G>A	c.(145-147)AAG>AAA	p.K49K	PCDHB6_uc011dah.1_Intron	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	49	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTTGACAAAGGACCTGGGAC	0.502000													18	106					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572902	140572902	+	Silent	SNP	C	T	T	rs150690310		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140572902C>T	uc003lix.2	+	1	951	c.777C>T	c.(775-777)TTC>TTT	p.F259F		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	259	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.F259F(1)		ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCATTGGGTTCCTTATTGTTA	0.463000													8	70					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626592	140626592	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140626592C>T	uc003lje.2	+	1	1446	c.1446C>T	c.(1444-1446)ACC>ACT	p.T482T		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	482	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGGGCACCAACGCCCAGG	0.657000													44	168					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140627416	140627416	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140627416G>A	uc003lje.2	+	1	2270	c.2270G>A	c.(2269-2271)GGA>GAA	p.G757E		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	757	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTCTGACGGGAGGCTCTGAA	0.517000													42	199					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711728	140711728	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140711728G>A	uc003lji.1	+	1	1477	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	PCDHGA1_uc011dan.1_Missense_Mutation_p.E493K	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	493	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCCTAATAGAGGACACTAT	0.537000													27	139					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712307	140712307	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140712307G>A	uc003lji.1	+	1	2056	c.2056G>A	c.(2056-2058)GAT>AAT	p.D686N	PCDHGA1_uc011dan.1_Missense_Mutation_p.D686N	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	686	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAACCCAACGATTCGGACCT	0.692000													58	201					0	0	1	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140790067	140790067	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140790067C>T	uc003lkj.1	+	1	2298	c.2298C>T	c.(2296-2298)TTC>TTT	p.F766F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Silent_p.F766F|PCDHGA10_uc011day.1_5'Flank|PCDHGA10_uc003lkl.1_5'Flank	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	766	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTTTAATTTCCTAAAATGCA	0.448000													14	63					0	0	1	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798931	140798931	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:140798931C>T	uc003lkn.1	+	1	1650	c.1505C>T	c.(1504-1506)TCG>TTG	p.S502L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.S502L|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	502	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAACGCTGTCGTCCTACGTG	0.657000													26	104					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143586423	143586423	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:143586423C>T	uc003lnm.1	+	3	775	c.146C>T	c.(145-147)TCC>TTC	p.S49F	KCTD16_uc003lnn.1_Missense_Mutation_p.S49F	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	49	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			ATCCCTCATTCCCTCCTGTGG	0.478000													14	54					0	0	1	0	0
GRXCR2	643226	broad.mit.edu	37	5	145239319	145239319	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:145239319G>A	uc003lns.1	-	3	724	c.724C>T	c.(724-726)CCT>TCT	p.P242S		NM_001080516	NP_001073985	A6NFK2	GRCR2_HUMAN	glutaredoxin, cysteine rich 2	242											0						ATCTGGCAAGGCTGTAGGCCA	0.517000													29	79					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145435603	145435603	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:145435603C>T	uc003lnt.2	+	8	1620	c.1382C>T	c.(1381-1383)TCC>TTC	p.S461F	SH3RF2_uc011dbl.1_Missense_Mutation_p.S461F|SH3RF2_uc011dbm.1_5'UTR|SH3RF2_uc003lnu.2_5'UTR|SH3RF2_uc011dbn.1_5'UTR	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	461							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGACGTTATCCACCTCCTCT	0.483000													46	227					0	0	1	0	0
SPINK5	11005	broad.mit.edu	37	5	147449898	147449898	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:147449898G>A	uc003lox.2	+	3	167	c.94G>A	c.(94-96)GAA>AAA	p.E32K	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Missense_Mutation_p.E4K|SPINK5_uc010jgr.2_Intron|SPINK5_uc003low.2_Missense_Mutation_p.E32K|SPINK5_uc003loy.2_Missense_Mutation_p.E32K	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	32	Kazal-like 1; atypical.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGTGCCATGAATTTCAGGC	0.274000													8	28					0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149749138	149749138	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:149749138C>T	uc003lry.2	+	6	720	c.612C>T	c.(610-612)TCC>TCT	p.S204S	TCOF1_uc003lrw.2_Silent_p.S204S|TCOF1_uc011dch.1_Silent_p.S204S|TCOF1_uc003lrz.2_Silent_p.S204S|TCOF1_uc003lrx.2_Silent_p.S204S|TCOF1_uc003lsa.2_Silent_p.S204S	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	204	Poly-Ser.				skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGGACACCTCCAGCTCCAGTG	0.622000													18	67					0	0	1	0	0
ANXA6	309	broad.mit.edu	37	5	150519721	150519721	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:150519721C>T	uc003ltl.1	-	3	254	c.102G>A	c.(100-102)AAG>AAA	p.K34K	ANXA6_uc011dcp.1_Silent_p.K2K|ANXA6_uc003ltm.1_Silent_p.K34K|ANXA6_uc003ltn.1_Silent_p.K34K|ANXA6_uc003lto.1_5'UTR	NM_001155	NP_001146	P08133	ANXA6_HUMAN	annexin VI isoform 1	34	Annexin 1.					melanosome	calcium ion binding|calcium-dependent phospholipid binding|protein binding				0		Medulloblastoma(196;0.0912)|all_hematologic(541;0.208)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CACCAAAGCCCTTCATGGCAG	0.567000													11	37					0	0	1	0	0
SLC36A1	206358	broad.mit.edu	37	5	150867796	150867796	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:150867796C>T	uc003luc.2	+	11	1629	c.1412C>T	c.(1411-1413)TCC>TTC	p.S471F	GM2A_uc011dcs.1_Intron	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	471	Extracellular (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TTCATCAATTCCACCTGTGCC	0.567000													8	47					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153149817	153149817	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:153149817G>A	uc003lva.3	+	13	2477	c.2112G>A	c.(2110-2112)ATG>ATA	p.M704I	GRIA1_uc003luy.3_Missense_Mutation_p.M704I|GRIA1_uc003luz.3_Missense_Mutation_p.M609I|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.M624I|GRIA1_uc011dcx.1_Missense_Mutation_p.M635I|GRIA1_uc011dcy.1_Missense_Mutation_p.M714I|GRIA1_uc011dcz.1_Missense_Mutation_p.M714I	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	704	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGGAGGGGATGATTCGAGTGA	0.488000													9	41					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154393562	154393562	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:154393562C>T	uc010jih.1	+	1	303	c.143C>T	c.(142-144)TCC>TTC	p.S48F		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	48	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			ACTGATAAATCCTTCACCTAC	0.488000													11	59					0	0	1	0	0
HAVCR2	84868	broad.mit.edu	37	5	156514297	156514297	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:156514297G>A	uc003lwk.1	-	7	866	c.722C>T	c.(721-723)TCT>TTT	p.S241F		NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	241	Cytoplasmic (Potential).					integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTGGCCAAAGAGATGAGGCT	0.403000													8	48					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156738751	156738751	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:156738751C>T	uc003lwq.2	+	13	1210	c.1072C>T	c.(1072-1074)CGC>TGC	p.R358C	CYFIP2_uc011ddn.1_Missense_Mutation_p.R332C|CYFIP2_uc011ddo.1_Missense_Mutation_p.R162C|CYFIP2_uc003lwr.2_Missense_Mutation_p.R358C|CYFIP2_uc003lws.2_Missense_Mutation_p.R358C|CYFIP2_uc003lwt.2_Missense_Mutation_p.R236C|CYFIP2_uc011ddp.1_Missense_Mutation_p.R92C	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	358					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGACCACATCCGCTTCATCTC	0.597000													3	15					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158250200	158250200	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:158250200G>A	uc010jip.2	-	8	1064	c.762C>T	c.(760-762)CCC>CCT	p.P254P	EBF1_uc011ddw.1_Silent_p.P121P|EBF1_uc011ddx.1_Silent_p.P254P|EBF1_uc003lxl.3_Intron	NM_024007	NP_076870	Q9UH73	COE1_HUMAN	early B-cell factor	254					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	soft_tissue(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAGATAAGAGGGCGTACCTT	0.468000			T	HMGA2	lipoma								5	35					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168244354	168244354	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:168244354C>T	uc003mab.2	-	8	1164	c.744G>A	c.(742-744)TTG>TTA	p.L248L	SLIT3_uc010jjg.2_Silent_p.L248L|SLIT3_uc010jji.2_Silent_p.L248L|SLIT3_uc003mac.1_Silent_p.L45L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	248	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGAAGCCCCTCAAATGCACAG	0.597000													24	78					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168310283	168310283	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:168310283C>T	uc003mab.2	-	5	892	c.472G>A	c.(472-474)GAT>AAT	p.D158N	SLIT3_uc010jjg.2_Missense_Mutation_p.D158N|SLIT3_uc010jji.2_Missense_Mutation_p.D158N	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	158	LRR 5.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTCTTCACATCGGTGATGCCG	0.507000													17	65					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169446040	169446040	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:169446040C>T	uc003maf.2	+	33	3389	c.3309C>T	c.(3307-3309)CTC>CTT	p.L1103L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.L595L	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1103	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGGCTGAGCTCCGGAAAGCCA	0.443000													45	178					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169494534	169494534	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:169494534G>A	uc003maf.2	+	45	4568	c.4488G>A	c.(4486-4488)GAG>GAA	p.E1496E	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.E988E|DOCK2_uc003mah.2_Silent_p.E52E	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1496	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTCCTCTGGAGAATGCCATAG	0.423000													15	69					0	0	1	0	0
KCNIP1	30820	broad.mit.edu	37	5	170147352	170147352	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:170147352G>A	uc003mas.2	+	4	776	c.247G>A	c.(247-249)GAC>AAC	p.D83N	KCNIP1_uc003map.2_Missense_Mutation_p.D81N|KCNIP1_uc003mat.2_Missense_Mutation_p.D72N|KCNIP1_uc010jjp.2_Missense_Mutation_p.D44N|KCNIP1_uc010jjq.2_Missense_Mutation_p.D72N	NM_001034837	NP_001030009	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1 isoform 1	83	EF-hand 1; degenerate.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTCAACGAAGACACATTCAA	0.557000													16	43					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170239211	170239211	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:170239211G>A	uc003mau.2	+	10	1470	c.1272G>A	c.(1270-1272)TTG>TTA	p.L424L	GABRP_uc011dev.1_3'UTR	NM_014211	NP_055026	O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	424	Helical; (Potential).					cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGTTTCCTTTGATTTTTATGC	0.348000													9	51					0	0	1	0	0
GRK6	2870	broad.mit.edu	37	5	176859235	176859236	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:176859235_176859236CC>TT	uc011dfz.1	+	4	423_424	c.263_264CC>TT	c.(262-264)GCC>GTT	p.A88V	GRK6_uc003mgp.2_Missense_Mutation_p.A88V|GRK6_uc003mgq.2_Missense_Mutation_p.A88V|GRK6_uc003mgs.1_Missense_Mutation_p.A58V	NM_002082	NP_002073	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6 isoform B	88	N-terminal.|RGS.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)|stomach(1)|breast(1)	3	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCCTGCAGGCCGAGTATGAAG	0.629000													13	102					0	0	1	0	0
AACSL	729522	broad.mit.edu	37	5	178199573	178199573	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:178199573C>T	uc011dgk.1	-	4		c.316G>A			AACSL_uc011dgl.1_RNA|AACSL_uc003mjk.2_RNA	NR_024035				Homo sapiens acetoacetyl-CoA synthetase-like, mRNA (cDNA clone IMAGE:3945810), partial cds.												0						ACCCTCTCTTCCCCGTACTTG	0.582000													5	35					0	0	1	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310557	178310557	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr5:178310557C>T	uc003mjl.2	+	5	1330	c.1104C>T	c.(1102-1104)TCC>TCT	p.S368S	ZNF354B_uc003mjm.2_Silent_p.S368S	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	368	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTAGCTCATCCCTTCGTTATC	0.413000													11	53					0	0	1	0	0
IRF4	3662	broad.mit.edu	37	6	401567	401567	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:401567G>A	uc003msz.3	+	7	1002	c.889G>A	c.(889-891)GAC>AAC	p.D297N	IRF4_uc010jne.1_Missense_Mutation_p.D297N|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.D296N|IRF4_uc003mtc.1_Missense_Mutation_p.D127N	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	297					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		CTACCCAGAGGACAATGGCCA	0.607000			T	IGH@	MM 								5	56					0	0	1	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890586	2890586	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:2890586G>A	uc003mug.2	-	7	1063	c.942C>T	c.(940-942)TTC>TTT	p.F314F	uc003mue.2_Intron|SERPINB9_uc003muf.2_Silent_p.F117F	NM_004155	NP_004146	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B, member 9	314					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.108)				TCTTGTGCACGAACTTGGACA	0.537000													27	104					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7583323	7583323	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:7583323G>A	uc003mxp.1	+	24	6107	c.5828G>A	c.(5827-5829)AGA>AAA	p.R1943K	DSP_uc003mxq.1_Missense_Mutation_p.R1344K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1943	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GATAAACTCAGACAGCGCCCA	0.527000													10	54					0	0	1	0	0
GPLD1	2822	broad.mit.edu	37	6	24448181	24448181	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:24448181G>A	uc003ned.1	-	17	1713	c.1602C>T	c.(1600-1602)TCC>TCT	p.S534S	GPLD1_uc010jpr.1_Silent_p.S371S|GPLD1_uc010jps.1_Silent_p.S534S	NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	534	FG-GAP 3.			VIGS -> MLGT (in Ref. 6; AA sequence).		extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						GTGCAAAAGGGGAGCCGATGA	0.532000													22	60					0	0	1	0	0
ZNF165	7718	broad.mit.edu	37	6	28056508	28056508	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:28056508G>A	uc003nkg.2	+	5	1802	c.718G>A	c.(718-720)GAA>AAA	p.E240K	ZNF165_uc003nkh.2_Missense_Mutation_p.E240K|ZNF165_uc003nki.3_Missense_Mutation_p.E240K|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	240					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ATGGGAAAAAGAATCAGGGGA	0.428000													24	114					0	0	1	0	0
PGBD1	84547	broad.mit.edu	37	6	28269969	28269969	+	Missense_Mutation	SNP	G	A	A	rs139051198		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:28269969G>A	uc003nky.2	+	7	2708	c.2338G>A	c.(2338-2340)GCC>ACC	p.A780T	PGBD1_uc003nkz.2_Missense_Mutation_p.A780T	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	780					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						ACTACACAGAGCCTGTAACCC	0.423000													8	37					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29055023	29055023	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:29055023C>T	uc003nlx.2	-	1	68	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						TTTCCCAATTCATGATGACTC	0.353000													8	25					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080470	29080470	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:29080470G>A	uc011dll.1	+	1	803	c.803G>A	c.(802-804)GGA>GAA	p.G268E		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	268	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCACCATCAGGAAATTCTCAA	0.428000													20	51					0	0	1	0	0
OR14J1	442191	broad.mit.edu	37	6	29274703	29274703	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:29274703C>T	uc011dln.1	+	1	237	c.237C>T	c.(235-237)TCC>TCT	p.S79S		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCCCCCAGTCCATTGCAAATT	0.463000													44	189					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408171	29408171	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:29408171G>A	uc011dlp.1	+	1	379	c.379G>A	c.(379-381)GAA>AAA	p.E127K	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGCCATCTGTGAACCCCTCCG	0.637000													10	57					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429564	29429564	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:29429564C>T	uc003nmi.2	+	3	461	c.18C>T	c.(16-18)TCC>TCT	p.S6S	OR2H1_uc003nmj.1_Silent_p.S6S|OR2H1_uc010jri.1_Intron	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACCAAAGCTCCCCCATGGGCT	0.527000													26	104					0	0	1	0	0
MOG	4340	broad.mit.edu	37	6	29627396	29627396	+	Missense_Mutation	SNP	G	A	A	rs139424758	by1000genomes	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:29627396G>A	uc003nnf.2	+	2	567	c.389G>A	c.(388-390)CGA>CAA	p.R130Q	MOG_uc003qzk.1_Missense_Mutation_p.R130Q|MOG_uc010kle.1_Intron|MOG_uc010klf.1_Intron|MOG_uc003nmy.1_Missense_Mutation_p.R130Q|MOG_uc003nmz.2_Missense_Mutation_p.R130Q|MOG_uc011dlt.1_Missense_Mutation_p.R60Q|MOG_uc003nna.2_Intron|MOG_uc011dlu.1_Intron|MOG_uc011dlv.1_Intron|MOG_uc003nnd.2_Missense_Mutation_p.R130Q|MOG_uc003nne.2_Missense_Mutation_p.R130Q|MOG_uc003nng.2_Missense_Mutation_p.R130Q|MOG_uc003nnh.2_Missense_Mutation_p.R130Q|MOG_uc003nni.2_Missense_Mutation_p.R130Q|MOG_uc003nnj.2_Missense_Mutation_p.R130Q|MOG_uc003nnk.2_Missense_Mutation_p.R130Q	NM_206809	NP_996532	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein isoform	130	Ig-like V-type.|Extracellular (Potential).				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)	1						TGCTTCTTCCGAGATCATTCT	0.448000													10	38					0	0	1	0	0
LTB	4050	broad.mit.edu	37	6	31550180	31550180	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:31550180C>T	uc003nuk.2	-	1	23	c.15G>A	c.(13-15)GGG>GGA	p.G5G	LTB_uc003nul.2_Silent_p.G5G	NM_002341	NP_002332	Q06643	TNFC_HUMAN	lymphotoxin-beta isoform a	5	Cytoplasmic (Potential).				cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding				0					Infliximab(DB00065)|Simvastatin(DB00641)	TGCCCTCCAGCCCCAGTGCCC	0.652000													13	41					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31759515	31759515	+	Splice_Site	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:31759515C>T	uc003nxe.2	-	8	1396	c.973_splice	c.e8-1	p.R325_splice	VARS_uc011doi.1_Splice_Site	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase						translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CATTAGGACGCTGATGGTGGA	0.592000													23	153					0	0	1	0	0
SLC44A4	80736	broad.mit.edu	37	6	31832678	31832678	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:31832678G>A	uc010jti.2	-	19	1907	c.1841C>T	c.(1840-1842)TCC>TTC	p.S614F	NEU1_uc003nxq.3_5'Flank|NEU1_uc010jtg.2_5'Flank|NEU1_uc003nxr.3_5'Flank|NEU1_uc010jth.2_5'Flank|NEU1_uc003nxs.3_5'Flank	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	614	Helical; (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	AAAAAAGAAGGACAGGACCCC	0.567000													3	30					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31895563	31895563	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:31895563T>C	uc011dor.1	+	1	298	c.34T>C	c.(34-36)TTC>CTC	p.F12L	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_Intron|C2_uc003nye.3_Missense_Mutation_p.F12L|C2_uc003nyf.2_Missense_Mutation_p.F12L|C2_uc010jtk.2_Missense_Mutation_p.F12L|C2_uc011doq.1_5'UTR|C2_uc003nyg.2_Missense_Mutation_p.F12L	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	Error:Variant_position_missing_in_P00751_after_alignment					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						TTGCCTGCTGTTCCTGTACCC	0.572000													73	310					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169252	32169252	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:32169252C>T	uc003obb.2	-	22	3920	c.3781G>A	c.(3781-3783)GAT>AAT	p.D1261N	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1261	LNR 3.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TGGAAGTGATCATGGCAGTAC	0.557000													14	97					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170021	32170021	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:32170021C>T	uc003obb.2	-	21	3726	c.3587G>A	c.(3586-3588)GGA>GAA	p.G1196E	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1196	LNR 1.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ATCCCAGTTTCCTCCCGGGCC	0.672000													11	62					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32170060	32170060	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:32170060C>T	uc003obb.2	-	21	3687	c.3548G>A	c.(3547-3549)GGA>GAA	p.G1183E	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1183	LNR 1.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GGCCCCATCTCCACTTCTGCC	0.677000													6	34					0	0	1	0	0
COL11A2	1302	broad.mit.edu	37	6	33138617	33138617	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:33138617G>A	uc003ocx.1	-	46	3672	c.3444C>T	c.(3442-3444)TTC>TTT	p.F1148F	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Silent_p.F1062F|COL11A2_uc003ocz.1_Silent_p.F1041F	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1148	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GGGGCCCATTGAATCCTCTTG	0.602000													7	164					0	0	1	0	0
ZBTB22	9278	broad.mit.edu	37	6	33284382	33284382	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:33284382G>A	uc003oeb.2	-	2	464	c.312C>T	c.(310-312)GCC>GCT	p.A104A	TAPBP_uc003odx.1_5'Flank|TAPBP_uc010jus.1_5'Flank|TAPBP_uc003ody.2_5'Flank|TAPBP_uc003odz.2_5'Flank|TAPBP_uc010jut.1_5'Flank|TAPBP_uc011drc.1_5'Flank|ZBTB22_uc010juu.2_Silent_p.A104A	NM_005453	NP_005444	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	104	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CAGTCTCAAAGGCGCCTGGGT	0.577000													34	150					0	0	1	0	0
DEF6	50619	broad.mit.edu	37	6	35289109	35289109	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:35289109C>T	uc003okk.2	+	11	1857	c.1818C>T	c.(1816-1818)TCC>TCT	p.S606S	DEF6_uc010jvs.2_Silent_p.S581S|DEF6_uc010jvt.2_Silent_p.S351S	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	606						cytoplasm|nucleus|plasma membrane					0						AGCAGAAGTCCCTCAATGGTG	0.592000													22	87					0	0	1	0	0
KCTD20	222658	broad.mit.edu	37	6	36438023	36438023	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:36438023C>T	uc003ome.2	+	2	540	c.149C>T	c.(148-150)CCC>CTC	p.P50L	KCTD20_uc011dtm.1_5'UTR|KCTD20_uc011dtn.1_5'UTR|KCTD20_uc010jwk.2_Missense_Mutation_p.P50L|KCTD20_uc011dto.1_Intron	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerisation domain	50						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2						CCTCTAGGTCCCAGGAATGAA	0.423000													22	95					0	0	1	0	0
STK38	11329	broad.mit.edu	37	6	36483234	36483234	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:36483234G>A	uc003omg.2	-	6	1138	c.550C>T	c.(550-552)CTG>TTG	p.L184L	STK38_uc003omh.2_Silent_p.L184L|STK38_uc003omi.2_Silent_p.L184L	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	184	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						TCTTCTGTCAGAGTGTCTTTT	0.323000													21	91					0	0	1	0	0
CPNE5	57699	broad.mit.edu	37	6	36759834	36759834	+	Silent	SNP	G	A	A	rs139245762	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:36759834G>A	uc003omr.1	-	8	571	c.504C>T	c.(502-504)TCC>TCT	p.S168S	CPNE5_uc003oms.1_Silent_p.S147S	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	168	C2 2.									skin(1)	1						GCTCCTCAGCGGACAGGATGA	0.567000													25	98					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37606323	37606323	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:37606323C>T	uc003onu.1	-	15	3836	c.2657G>A	c.(2656-2658)GGG>GAG	p.G886E	MDGA1_uc003onv.1_Missense_Mutation_p.G155E	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	MAM domain containing	886	MAM.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)	2						CTGGAAGGGCCCACTGGGGCT	0.622000													17	86					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38820524	38820524	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:38820524G>A	uc003ooe.1	+	38	5470	c.4870G>A	c.(4870-4872)GAC>AAC	p.D1624N		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TCATGCAAAAGACTATGATCG	0.368000													9	59					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38906603	38906603	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:38906603G>A	uc003ooe.1	+	77	11795	c.11195G>A	c.(11194-11196)AGA>AAA	p.R3732K	DNAH8_uc003oog.1_Missense_Mutation_p.R181K|uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCTCAAAAGAGAATTACAAAT	0.303000													6	29					0	0	1	0	0
KCNK5	8645	broad.mit.edu	37	6	39162039	39162039	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:39162039G>A	uc003oon.2	-	4	904	c.540C>T	c.(538-540)TTC>TTT	p.F180F		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	180	Helical; (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						CCATGAATACGAAGGGTGGGA	0.572000													24	109					0	0	1	0	0
KCNK16	83795	broad.mit.edu	37	6	39282876	39282876	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:39282876C>T	uc003ooq.2	-	6	846	c.832G>A	c.(832-834)GCT>ACT	p.A278T	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_3'UTR|KCNK16_uc010jwy.2_Missense_Mutation_p.A231T	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	278	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						CTGCCTGGAGCCGCCTTGGCT	0.577000													15	127					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43400951	43400951	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:43400951C>T	uc003ouy.1	+	3	1448	c.1233C>T	c.(1231-1233)ACC>ACT	p.T411T	ABCC10_uc003ouz.1_Silent_p.T368T|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	411	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TGGCCATCACCCTCTACCTGC	0.592000													9	46					0	0	1	0	0
DLK2	65989	broad.mit.edu	37	6	43418978	43418978	+	Missense_Mutation	SNP	C	T	T	rs142658388		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:43418978C>T	uc003ova.2	-	6	660	c.451G>A	c.(451-453)GAC>AAC	p.D151N	DLK2_uc003ovb.2_Missense_Mutation_p.D151N	NM_023932	NP_076421	Q6UY11	DLK2_HUMAN	EGF-like-domain, multiple 9 precursor	151	Extracellular (Potential).|EGF-like 4.					integral to membrane	calcium ion binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			AAGCCCTGGTCGTCCTGGCAC	0.542000													10	55					0	0	1	0	0
IL17A	3605	broad.mit.edu	37	6	52051236	52051236	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:52051236C>T	uc003pak.1	+	1	52	c.7C>T	c.(7-9)CCT>TCT	p.P3S		NM_002190	NP_002181	Q16552	IL17_HUMAN	interleukin 17A precursor	3					apoptosis|cell-cell signaling|fibroblast activation|immune response|inflammatory response|positive regulation of interleukin-23 production|positive regulation of osteoclast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein glycosylation	extracellular space	cytokine activity				0	Lung NSC(77;0.116)					AACGATGACTCCTGGGAAGAC	0.483000													7	37					0	0	1	0	0
EFHC1	114327	broad.mit.edu	37	6	52317558	52317558	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:52317558C>T	uc003pap.3	+	4	861	c.646C>T	c.(646-648)CGA>TGA	p.R216*	EFHC1_uc011dwv.1_Nonsense_Mutation_p.R125*|EFHC1_uc011dww.1_Nonsense_Mutation_p.R197*	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	216						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					CACTGAACTCCGAAAACAGCC	0.378000													15	119					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55939081	55939081	+	Silent	SNP	A	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:55939081A>T	uc003pcs.2	-	20	2146	c.1914T>A	c.(1912-1914)GGT>GGA	p.G638G	COL21A1_uc010jzz.2_Silent_p.G23G|COL21A1_uc011dxg.1_Silent_p.G23G|COL21A1_uc011dxh.1_Silent_p.G23G|COL21A1_uc003pcr.2_5'UTR	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	638	Collagen-like 3.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTCCCATTAAACCCTACAATT	0.323000													7	53					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56035908	56035908	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:56035908C>T	uc003pcs.2	-	4	891	c.659G>A	c.(658-660)CGA>CAA	p.R220Q	COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.R220Q|COL21A1_uc003pcu.1_Missense_Mutation_p.R220Q	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	220					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CACTGGAATTCGTGTTGGACA	0.323000													13	57					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56373515	56373515	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:56373515C>T	uc003pdf.2	-	69	12722	c.12694G>A	c.(12694-12696)GAG>AAG	p.E4232K	DST_uc003pcz.3_Missense_Mutation_p.E4054K|DST_uc011dxj.1_Missense_Mutation_p.E4083K|DST_uc011dxk.1_Missense_Mutation_p.E4094K|DST_uc003pcy.3_Missense_Mutation_p.E3728K	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6140	Spectrin 12.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGTATGTTCTCCCAAATGAAA	0.438000													4	26					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62757842	62757842	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:62757842C>T	uc003peg.2	-	3	524	c.277G>A	c.(277-279)GAA>AAA	p.E93K		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	93	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		CCTGTTTCTTCCTGTAGCCTC	0.373000													9	70					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990527	63990527	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:63990527T>A	uc003peh.2	-	4	963	c.929A>T	c.(928-930)GAT>GTT	p.D310V	LGSN_uc003pei.2_Intron	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	310					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	AATCCCTGAATCACAAAATCC	0.418000													15	42					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	64004951	64004951	+	Splice_Site	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:64004951C>T	uc003peh.2	-	2	65	c.31_splice	c.e2-1	p.D11_splice	LGSN_uc003pei.2_Splice_Site_p.D11_splice|LGSN_uc003pej.1_Splice_Site_p.D11_splice	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase						glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	TTGTTGAGTCCTGTTGATAAT	0.323000													4	33					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70070838	70070838	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:70070838G>A	uc003pev.3	+	29	4121	c.3673G>A	c.(3673-3675)GAA>AAA	p.E1225K	BAI3_uc010kak.2_Missense_Mutation_p.E1225K|BAI3_uc011dxx.1_Missense_Mutation_p.E431K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1225	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AAATGATGATGAAGAAGAAAA	0.413000													8	31					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70916638	70916638	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:70916638C>T	uc003pfc.1	+	50	3374	c.3257C>T	c.(3256-3258)CCT>CTT	p.P1086L		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1086	Triple-helical region 6 (COL6).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						AGAGGTGAACCTGGAATTGGG	0.448000													3	31					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70935696	70935696	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:70935696C>T	uc003pfg.3	-	37	2679	c.2520G>A	c.(2518-2520)AAG>AAA	p.K840K	COL9A1_uc003pfe.3_Silent_p.K389K|COL9A1_uc003pff.3_Silent_p.K597K	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	840	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CACGCTCCCCCTTTTCTCCCA	0.423000													15	66					0	0	1	0	0
EEF1A1	1915	broad.mit.edu	37	6	74229188	74229188	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:74229188C>T	uc003phi.2	-	2	233	c.196G>A	c.(196-198)GAG>AAG	p.E66K	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.E66K|EEF1A1_uc003phf.2_Missense_Mutation_p.E66K|EEF1A1_uc003phg.2_Missense_Mutation_p.E66K|EEF1A1_uc003phh.2_Intron|EEF1A1_uc003phj.2_Missense_Mutation_p.E66K|EEF1A1_uc003phk.2_Missense_Mutation_p.E66K|EEF1A1_uc003phl.2_Missense_Mutation_p.E66K|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	66						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						CGTTCACGCTCAGCTTTCAGT	0.433000											OREG0003890	type=REGULATORY REGION|Gene=LOC477388|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	22	97					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84371276	84371276	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:84371276C>T	uc011dze.1	-	5	714	c.397G>A	c.(397-399)GAA>AAA	p.E133K	SNAP91_uc003pkb.2_Missense_Mutation_p.E98K|SNAP91_uc003pkc.2_Missense_Mutation_p.E133K|SNAP91_uc003pkd.2_Missense_Mutation_p.E133K|SNAP91_uc003pka.2_Missense_Mutation_p.E133K|SNAP91_uc011dzf.1_Missense_Mutation_p.E14K	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	133	ENTH.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		AAAGCCTTTTCATTCAAATAT	0.328000													5	34					0	0	1	0	0
SPACA1	81833	broad.mit.edu	37	6	88767428	88767428	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:88767428G>A	uc003pmn.2	+	3	481	c.364G>A	c.(364-366)GGC>AGC	p.G122S		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor	122	Extracellular (Potential).					integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		AACAGATTGTGGCTGTGAGTT	0.448000													12	63					0	0	1	0	0
GPR63	81491	broad.mit.edu	37	6	97246360	97246360	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:97246360C>T	uc010kcl.2	-	3	1726	c.1248G>A	c.(1246-1248)CGG>CGA	p.R416R	GPR63_uc003pou.2_Silent_p.R416R	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	416	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		ACACCACCGTCCGATGTTCCC	0.448000													11	45					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102124506	102124506	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:102124506C>T	uc003pqp.3	+	4	799	c.550C>T	c.(550-552)CGT>TGT	p.R184C	GRIK2_uc003pqn.2_Missense_Mutation_p.R184C|GRIK2_uc003pqo.3_Missense_Mutation_p.R184C|GRIK2_uc010kcw.2_Missense_Mutation_p.R184C	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	184	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AGGTCTCATTCGTTTGCAAGA	0.313000													3	22					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106543594	106543594	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:106543594G>A	uc003prd.2	+	3	630	c.396G>A	c.(394-396)AGG>AGA	p.R132R		NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	132	SET.				negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACGCCAACAGGAAATATTTTT	0.408000			D|N|Mis|F|S		DLBCL								17	25					0	0	1	0	0
AIM1	202	broad.mit.edu	37	6	106967944	106967944	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:106967944T>C	uc003prh.2	+	2	2124	c.1637T>C	c.(1636-1638)CTC>CCC	p.L546P		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	546							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TCCAGAGTCCTCGTCCAGGTC	0.542000													11	46					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111696200	111696200	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:111696200G>A	uc003puy.3	-	13	3681	c.3358C>T	c.(3358-3360)CCC>TCC	p.P1120S	REV3L_uc003pux.3_Missense_Mutation_p.P1042S|REV3L_uc003puz.3_Missense_Mutation_p.P1042S	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1120					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GAATTTATGGGACTTGTGCTT	0.438000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					10	96					0	0	1	0	0
FAM26E	254228	broad.mit.edu	37	6	116833295	116833295	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:116833295C>T	uc003pwy.2	+	1	488	c.436C>T	c.(436-438)CCC>TCC	p.P146S	BET3L_uc003pwx.2_Intron|BET3L_uc011ebh.1_Intron	NM_153711	NP_714922	Q8N5C1	FA26E_HUMAN	hypothetical protein LOC254228	146						integral to membrane					0		all_cancers(87;0.0608)|all_epithelial(87;0.05)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0242)|all cancers(137;0.0419)|OV - Ovarian serous cystadenocarcinoma(136;0.0671)|Epithelial(106;0.212)		CAAGGGTAAGCCCAAAGAGTG	0.483000													6	42					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117130604	117130604	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:117130604C>T	uc003pxj.1	-	2	393	c.371G>A	c.(370-372)AGA>AAA	p.R124K	GPRC6A_uc003pxk.1_Missense_Mutation_p.R124K|GPRC6A_uc003pxl.1_Missense_Mutation_p.R124K	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	124	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CACAGTTTCTCTGGAGCAGTT	0.448000													4	42					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117245927	117245927	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:117245927T>G	uc003pxm.2	+	15	1714	c.1651T>G	c.(1651-1653)TTA>GTA	p.L551V		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	551					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GTTACAGAATTTATTGGACAA	0.313000													4	39					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762176	130762176	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:130762176G>A	uc003qca.2	+	3	1480	c.609G>A	c.(607-609)TCG>TCA	p.S203S	TMEM200A_uc010kfh.2_Silent_p.S203S|TMEM200A_uc010kfi.2_Silent_p.S203S|TMEM200A_uc003qcb.2_Silent_p.S203S	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	203	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		CCTGTGCCTCGAGATTGGCAG	0.463000													6	34					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131216217	131216217	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:131216217C>T	uc003qch.2	-	9	1461	c.1279G>A	c.(1279-1281)GGA>AGA	p.G427R	EPB41L2_uc003qcg.1_Missense_Mutation_p.G427R|EPB41L2_uc011eby.1_Missense_Mutation_p.G427R|EPB41L2_uc003qci.2_Missense_Mutation_p.G427R|EPB41L2_uc010kfk.2_Missense_Mutation_p.G427R|EPB41L2_uc010kfl.1_Missense_Mutation_p.G427R	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	427	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		ATGAGAAGTCCATTAGCACAC	0.403000													19	95					0	0	1	0	0
VNN1	8876	broad.mit.edu	37	6	133013597	133013597	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:133013597G>A	uc003qdo.2	-	5	973	c.953C>T	c.(952-954)TCC>TTC	p.S318F		NM_004666	NP_004657	O95497	VNN1_HUMAN	vanin 1 precursor	318	CN hydrolase.				acute inflammatory response|anti-apoptosis|cell-cell adhesion|cellular component movement|chronic inflammatory response|innate immune response|pantothenate metabolic process|positive regulation of T cell differentiation in thymus|response to oxidative stress	anchored to membrane|integral to membrane|plasma membrane	GPI anchor binding|pantetheine hydrolase activity			ovary(3)	3	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.0027)|GBM - Glioblastoma multiforme(226;0.0189)		GCTGGCATAGGAAGTCCAGTT	0.443000													5	34					0	0	1	0	0
TCF21	6943	broad.mit.edu	37	6	134210647	134210647	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:134210647A>C	uc003qei.3	+	1	388	c.112A>C	c.(112-114)ACC>CCC	p.T38P	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.T38P	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	38					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CAACGAGAGCACCGAGGAGAG	0.587000													12	72					0	0	1	0	0
PDE7B	27115	broad.mit.edu	37	6	136512841	136512841	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:136512841C>T	uc003qgp.2	+	13	1519	c.1216C>T	c.(1216-1218)CTC>TTC	p.L406F	uc003qgq.1_Intron|PDE7B_uc003qgr.2_Missense_Mutation_p.L458F	NM_018945	NP_061818	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	406	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	GCTGGGCCACCTCGCACACAA	0.622000													3	29					0	0	1	0	0
FAM54A	113115	broad.mit.edu	37	6	136562768	136562768	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:136562768G>A	uc010kgp.1	-	5	718	c.328C>T	c.(328-330)CCT>TCT	p.P110S	FAM54A_uc003qgt.1_Missense_Mutation_p.P110S|FAM54A_uc003qgu.1_Missense_Mutation_p.P67S	NM_001099286	NP_001092756	Q6P444	FA54A_HUMAN	DUF729 domain containing 1	110										skin(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00228)|OV - Ovarian serous cystadenocarcinoma(155;0.00504)		AGTCGCAAAGGATGAAAAATT	0.358000													5	49					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599467	136599467	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:136599467C>T	uc003qgx.1	-	4	805	c.552G>A	c.(550-552)CAG>CAA	p.Q184Q	BCLAF1_uc003qgw.1_Silent_p.Q184Q|BCLAF1_uc003qgy.1_Silent_p.Q182Q|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.Q182Q	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	184					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TCGGTTCCTCCTGTGATTTAC	0.428000													5	129					0	0	1	0	0
MAP7	9053	broad.mit.edu	37	6	136677832	136677832	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:136677832C>T	uc003qgz.2	-	16	2259	c.2013G>A	c.(2011-2013)GAG>GAA	p.E671E	MAP7_uc011edf.1_Silent_p.E656E|MAP7_uc011edg.1_Silent_p.E701E|MAP7_uc010kgu.2_Silent_p.E693E|MAP7_uc011edh.1_Silent_p.E656E|MAP7_uc010kgv.2_Silent_p.E693E|MAP7_uc010kgs.2_Silent_p.E525E|MAP7_uc011edi.1_Silent_p.E525E|MAP7_uc010kgq.1_Silent_p.E577E|MAP7_uc003qha.1_Silent_p.E634E	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	671					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AAACTCACCTCTCCACTGTCA	0.418000													7	39					0	0	1	0	0
MAP7	9053	broad.mit.edu	37	6	136687111	136687111	+	Silent	SNP	C	T	T	rs143331676	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:136687111C>T	uc003qgz.2	-	10	1281	c.1035G>A	c.(1033-1035)CCG>CCA	p.P345P	MAP7_uc011edf.1_Silent_p.P330P|MAP7_uc011edg.1_Silent_p.P375P|MAP7_uc010kgu.2_Silent_p.P367P|MAP7_uc011edh.1_Silent_p.P330P|MAP7_uc010kgv.2_Silent_p.P367P|MAP7_uc010kgs.2_Silent_p.P199P|MAP7_uc011edi.1_Silent_p.P199P|MAP7_uc010kgq.1_Silent_p.P251P|MAP7_uc003qha.1_Silent_p.P308P|MAP7_uc010kgr.2_Silent_p.P199P	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	345	Pro-rich.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AGGAGGATGTCGGTCTGGGTG	0.592000													16	70					0	0	1	0	0
RAET1K	646024	broad.mit.edu	37	6	150322324	150322324	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:150322324C>T	uc003qnq.2	-	2		c.553G>A				NR_024045				Homo sapiens RAET1K mRNA, partial sequence.												0						CACCCTGCTTCCTTTCCTGGC	0.507000													4	15					0	0	1	0	0
MYCT1	80177	broad.mit.edu	37	6	153043126	153043126	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:153043126C>T	uc003qpd.3	+	2	454	c.446C>T	c.(445-447)TCC>TTC	p.S149F	MYCT1_uc010kjc.1_Missense_Mutation_p.S101F|MYCT1_uc003qpc.3_Missense_Mutation_p.S149F	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	149						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		CGACAAGCTTCCCTGGAACAA	0.498000													24	87					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155451411	155451411	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:155451411C>T	uc003qqb.2	+	6	2327	c.1054C>T	c.(1054-1056)CAG>TAG	p.Q352*	TIAM2_uc003qqe.2_Nonsense_Mutation_p.Q352*	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	352					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GGACCCCATCCAGTACAGTTC	0.547000													16	70					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159692398	159692398	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:159692398G>A	uc010kjv.2	+	23	5809	c.5609G>A	c.(5608-5610)GGG>GAG	p.G1870E		NM_032532	NP_115921	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1870						extracellular region				large_intestine(4)|ovary(3)|central_nervous_system(1)	8		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		GTCAGGTTTGGGAACATCGGC	0.562000													8	19					0	0	1	0	0
SLC22A3	6581	broad.mit.edu	37	6	160829906	160829906	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:160829906C>T	uc003qti.2	+	4	837	c.810C>T	c.(808-810)ATC>ATT	p.I270I	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	270	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GGCAAGGAATCCAGTTAGCCA	0.408000													17	47					0	0	1	0	0
QKI	9444	broad.mit.edu	37	6	163876429	163876429	+	Nonsense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:163876429T>A	uc003qui.2	+	2	812	c.261T>A	c.(259-261)TAT>TAA	p.Y87*	QKI_uc003que.2_Nonsense_Mutation_p.Y87*|QKI_uc003quf.2_Nonsense_Mutation_p.Y87*|QKI_uc003qug.2_Nonsense_Mutation_p.Y87*|QKI_uc003quh.2_Nonsense_Mutation_p.Y87*|QKI_uc003quj.2_Nonsense_Mutation_p.Y87*	NM_006775	NP_006766	Q96PU8	QKI_HUMAN	quaking homolog, KH domain RNA binding isoform	87	KH.				mRNA processing|mRNA transport|regulation of translation|RNA splicing	cytoplasm|nucleus|plasma membrane	RNA binding|SH3 domain binding			large_intestine(1)|ovary(1)	2		Breast(66;5e-05)|Prostate(117;0.0235)|all_neural(5;0.0416)|Ovarian(120;0.0448)|Glioma(2;0.203)		all cancers(1;4.4e-46)|OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|GBM - Glioblastoma multiforme(1;2.94e-19)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|Kidney(3;0.000199)|KIRC - Kidney renal clear cell carcinoma(3;0.000234)		AGAAACTTTATGTGCCTGTAA	0.348000													27	107					0	0	1	0	0
FRMD1	79981	broad.mit.edu	37	6	168467485	168467485	+	Silent	SNP	G	A	A	rs140475200	by1000genomes	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:168467485G>A	uc003qwo.3	-	4	476	c.411C>T	c.(409-411)TTC>TTT	p.F137F	FRMD1_uc003qwm.3_5'Flank|FRMD1_uc011egs.1_5'UTR|FRMD1_uc011egt.1_Silent_p.F49F|FRMD1_uc003qwn.3_Silent_p.F69F	NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	137	FERM.					cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GGAAGGCCACGAAGGGGGCTC	0.547000													10	65					0	0	1	0	0
SMOC2	64094	broad.mit.edu	37	6	169008849	169008849	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr6:169008849G>A	uc003qws.1	+	9	857	c.837G>A	c.(835-837)CCG>CCA	p.P279P	SMOC2_uc003qwr.1_Silent_p.P290P	NM_022138	NP_071421	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	279	Thyroglobulin type-1 2.				signal transduction	basement membrane	calcium ion binding			ovary(1)	1		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		ACGAGCAGCCGAAATGTGACA	0.612000													7	29					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2962271	2962271	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:2962271C>T	uc003smv.2	-	17	2670	c.2266G>A	c.(2266-2268)GAA>AAA	p.E756K		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	756					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GTCTCACCTTCGTGGTTGACC	0.493000			Mis		DLBCL								21	68					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4281441	4281441	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:4281441C>T	uc003smx.2	+	43	6286	c.6147C>T	c.(6145-6147)ACC>ACT	p.T2049T	SDK1_uc010kso.2_Silent_p.T1305T|SDK1_uc003smy.2_Silent_p.T536T|SDK1_uc003smz.2_Silent_p.T109T	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	2049	Extracellular (Potential).|Cytoplasmic (Potential).				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGATCTCCACCATGGAGGAGT	0.602000													13	46					0	0	1	0	0
RSPH10B2	728194	broad.mit.edu	37	7	5967999	5967999	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:5967999G>A	uc003sph.1	-	20	2531	c.2260C>T	c.(2260-2262)CGA>TGA	p.R754*	RSPH10B2_uc003spg.1_Nonsense_Mutation_p.R601*|RSPH10B2_uc010ktd.1_Nonsense_Mutation_p.R754*|RSPH10B2_uc011jwk.1_Silent_p.I375I	NM_173565	NP_775836	B2RC85	R10B2_HUMAN	radial spoke head 10 homolog B	754										ovary(1)|pancreas(1)|skin(1)	3						TCTTCCTCTCGATCATCCTTG	0.418000													19	221					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23792410	23792410	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:23792410G>A	uc003sws.3	+	9	1159	c.1092G>A	c.(1090-1092)ATG>ATA	p.M364I	STK31_uc003swt.3_Missense_Mutation_p.M341I|STK31_uc011jze.1_Missense_Mutation_p.M364I|STK31_uc010kuq.2_Missense_Mutation_p.M341I	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	364							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						ATACCAGAATGAAAAATCTGG	0.338000													6	62					0	0	1	0	0
EVX1	2128	broad.mit.edu	37	7	27282763	27282763	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:27282763G>A	uc003szd.1	+	1	600	c.114G>A	c.(112-114)CCG>CCA	p.P38P	EVX1_uc011jzn.1_5'UTR|EVX1_uc010kuy.1_Silent_p.P38P	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	38						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TGCCGGAGCCGCCCGAGAAAA	0.672000													9	14					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28610022	28610022	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:28610022G>A	uc003szq.2	+	5	721	c.331G>A	c.(331-333)GGG>AGG	p.G111R	CREB5_uc003szo.2_Missense_Mutation_p.G78R|CREB5_uc003szr.2_Missense_Mutation_p.G104R	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	111					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						GGCCATGACGGGGCCCGGAAC	0.537000													13	106					0	0	1	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378112	31378112	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:31378112T>A	uc003tch.2	-	2	1124	c.771A>T	c.(769-771)GAA>GAT	p.E257D		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	257					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						TTAAGGGACCTTCAAACTGAG	0.408000													17	40					0	0	1	0	0
PDE1C	5137	broad.mit.edu	37	7	31918727	31918727	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:31918727G>A	uc003tcm.1	-	4	776	c.307C>T	c.(307-309)CGA>TGA	p.R103*	PDE1C_uc003tcn.1_Nonsense_Mutation_p.R103*|PDE1C_uc003tco.1_Nonsense_Mutation_p.R163*|PDE1C_uc003tcr.2_Nonsense_Mutation_p.R103*|PDE1C_uc003tcs.2_Nonsense_Mutation_p.R103*	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	103					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AGCCAGTCTCGGACCTCAGAA	0.552000													7	62					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33427661	33427661	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:33427661C>T	uc003tdn.1	+	19	2533	c.2020C>T	c.(2020-2022)CGG>TGG	p.R674W	BBS9_uc003tdo.1_Missense_Mutation_p.R639W|BBS9_uc003tdp.1_Missense_Mutation_p.R669W|BBS9_uc003tdq.1_Missense_Mutation_p.R634W|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.R198W|BBS9_uc003tds.1_Missense_Mutation_p.R97W|BBS9_uc003tdt.2_RNA	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	674					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TGTACAATTTCGGGCCATTCA	0.403000									Bardet-Biedl_syndrome				40	146					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44555703	44555703	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:44555703T>C	uc003tlb.2	-	18	3750	c.3694A>G	c.(3694-3696)ACC>GCC	p.T1232A	NPC1L1_uc003tlc.2_Missense_Mutation_p.T1205A|NPC1L1_uc011kbw.1_Missense_Mutation_p.T1159A|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1232	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	ATAGAGATGGTGGCCTCTTTG	0.627000													3	21					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44555716	44555716	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:44555716C>T	uc003tlb.2	-	18	3737	c.3681G>A	c.(3679-3681)AGG>AGA	p.R1227R	NPC1L1_uc003tlc.2_Silent_p.R1200R|NPC1L1_uc011kbw.1_Silent_p.R1154R|NPC1L1_uc003tla.2_Intron	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	1227	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	CCTCTTTGGCCCTCTCCAGCC	0.627000													7	15					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44805791	44805791	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:44805791C>T	uc003tlr.2	+	17	2394	c.2271C>T	c.(2269-2271)TTC>TTT	p.F757F	ZMIZ2_uc003tlq.2_Silent_p.F699F|ZMIZ2_uc003tls.2_Silent_p.F731F|ZMIZ2_uc003tlt.2_Silent_p.F380F|ZMIZ2_uc010kyj.2_Silent_p.F279F|ZMIZ2_uc003tlu.2_Silent_p.F38F|ZMIZ2_uc010kyk.1_5'Flank	NM_031449	NP_113637	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2 isoform 1	757	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			ovary(2)|large_intestine(2)|breast(1)	5						CTGGAACTTTCCCTGAGTCCT	0.662000													6	79					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45699774	45699774	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:45699774C>T	uc003tne.3	+	7	1459	c.1441C>T	c.(1441-1443)CGC>TGC	p.R481C	ADCY1_uc003tnd.2_Missense_Mutation_p.R256C	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	481	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCATCCCATCGCCGAAAGGT	0.488000													16	62					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48411914	48411914	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:48411914C>T	uc003toq.2	+	33	10978	c.10953C>T	c.(10951-10953)TTC>TTT	p.F3651F	ABCA13_uc010kys.1_Silent_p.F725F|ABCA13_uc003tos.1_Silent_p.F477F	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3651	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTATTGTTTTCCTCTTTCTCT	0.468000													14	158					0	0	1	0	0
IKZF1	10320	broad.mit.edu	37	7	50468045	50468045	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:50468045C>T	uc003tow.3	+	9	1448	c.1280C>T	c.(1279-1281)TCG>TTG	p.S427L	IKZF1_uc003tox.3_Missense_Mutation_p.S385L|IKZF1_uc003toy.3_Missense_Mutation_p.S385L|IKZF1_uc011kck.1_Missense_Mutation_p.S340L|IKZF1_uc003toz.3_Missense_Mutation_p.S397L|IKZF1_uc010kyx.2_Missense_Mutation_p.S167L|IKZF1_uc003tpa.3_Missense_Mutation_p.S169L	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	427					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				AACGGGCTGTCGCTCAAGGAG	0.672000			D		ALL								4	43					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63726636	63726636	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:63726636G>A	uc003tsx.2	+	5	894	c.625G>A	c.(625-627)GAG>AAG	p.E209K		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCATACTAGGGAGAATTCCTA	0.358000													5	10					0	0	1	0	0
LOC168474	168474	broad.mit.edu	37	7	64313333	64313333	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:64313333C>T	uc003ttj.1	-	1	846	c.294G>A	c.(292-294)AGG>AGA	p.R98R		NR_002789				SubName: Full=Selenophosphate synthetase 1; SubName: Full=Selenophosphate synthetase 1, isoform CRA_a;												0						TATCCATTTCCCTGTTGGTCA	0.463000													5	44					0	0	1	0	0
GUSB	2990	broad.mit.edu	37	7	65445369	65445369	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:65445369G>A	uc003tun.2	-	2	314	c.238C>T	c.(238-240)CCC>TCC	p.P80S	GUSB_uc011kdt.1_Missense_Mutation_p.P80S|GUSB_uc010kzw.1_5'UTR	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	80					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						AAGCTGGAGGGAACTGGCATG	0.502000													7	38					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	70598008	70598008	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:70598008G>A	uc003tvy.2	+	1	220	c.220G>A	c.(220-222)GTG>ATG	p.V74M		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	74	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGAGGACATCGTGTACCGGCA	0.731000													4	14					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72040539	72040539	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:72040539G>A	uc011kej.1	-	17	2110	c.1951C>T	c.(1951-1953)CCC>TCC	p.P651S	TYW1B_uc011keh.1_Intron|TYW1B_uc011kei.1_Missense_Mutation_p.P277S	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	651					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						GTGTCCTTGGGATCAAAGCTT	0.403000													16	77					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76889522	76889522	+	Silent	SNP	A	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:76889522A>C	uc003uga.2	+	8	1082	c.955A>C	c.(955-957)AGA>CGA	p.R319R	CCDC146_uc010ldp.2_Silent_p.R65R	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	319	Potential.									ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				GGAATTAGCCAGAGAGAATGA	0.308000													10	65					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77764489	77764489	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:77764489C>T	uc003ugx.2	-	17	3134	c.2880G>A	c.(2878-2880)GGG>GGA	p.G960G	MAGI2_uc003ugy.2_Silent_p.G946G|MAGI2_uc010ldx.1_Silent_p.G553G	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	960	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CTGCAGGACTCCCATCAATGA	0.483000													17	113					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77973175	77973175	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:77973175C>T	uc003ugx.2	-	9	1582	c.1328G>A	c.(1327-1329)GGA>GAA	p.G443E	MAGI2_uc003ugy.2_Missense_Mutation_p.G443E|MAGI2_uc010ldx.1_Missense_Mutation_p.G52E|MAGI2_uc010ldy.1_Missense_Mutation_p.G52E|MAGI2_uc011kgr.1_Missense_Mutation_p.G275E|MAGI2_uc011kgs.1_Missense_Mutation_p.G280E	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	443	PDZ 2.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AGGCTCGTCTCCACCAATGAT	0.483000													30	48					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82474594	82474594	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:82474594C>T	uc003uhx.2	-	13	14328	c.14039G>A	c.(14038-14040)AGC>AAC	p.S4680N	PCLO_uc003uhv.2_Missense_Mutation_p.S4680N|PCLO_uc003uht.1_Missense_Mutation_p.S131N|PCLO_uc003uhu.1_Missense_Mutation_p.S110N	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4568	C2 1.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CACCTTGCTGCTGCCGTGCTT	0.458000													3	27					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82580167	82580167	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:82580167C>T	uc003uhx.2	-	6	10026	c.9737G>A	c.(9736-9738)CGA>CAA	p.R3246Q	PCLO_uc003uhv.2_Missense_Mutation_p.R3246Q|PCLO_uc010lec.2_Missense_Mutation_p.R211Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3177	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTCTTGTTCTCGGAACCTTTG	0.473000													6	80					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584275	82584275	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:82584275C>T	uc003uhx.2	-	5	6283	c.5994G>A	c.(5992-5994)CAG>CAA	p.Q1998Q	PCLO_uc003uhv.2_Silent_p.Q1998Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1929					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTCATAAATCTGTTCTGAAA	0.373000													11	129					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82586199	82586199	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:82586199G>A	uc003uhx.2	-	5	4359	c.4070C>T	c.(4069-4071)CCC>CTC	p.P1357L	PCLO_uc003uhv.2_Missense_Mutation_p.P1357L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1288					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CAGACCTTGGGGGCTTTTAGG	0.408000													7	29					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82595376	82595376	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:82595376G>A	uc003uhx.2	-	4	4017	c.3728C>T	c.(3727-3729)CCT>CTT	p.P1243L	PCLO_uc003uhv.2_Missense_Mutation_p.P1243L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1182					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTTGTCTTCAGGGGTTGGCTT	0.378000													32	176					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	83029535	83029535	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:83029535C>T	uc003uhy.1	-	11	1641	c.1175G>A	c.(1174-1176)GGA>GAA	p.G392E		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	392	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CTTGGTGGTTCCGTATCTCCC	0.383000													7	100					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394693	86394693	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:86394693G>A	uc003uid.2	+	2	1331	c.232G>A	c.(232-234)GAA>AAA	p.E78K	GRM3_uc010lef.2_Missense_Mutation_p.E76K|GRM3_uc010leg.2_Intron|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	78	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGCTATTGATGAAATCAACAA	0.423000													16	107					0	0	1	0	0
DMTF1	9988	broad.mit.edu	37	7	86820320	86820320	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:86820320C>T	uc003uih.2	+	14	1797	c.1471C>T	c.(1471-1473)CTA>TTA	p.L491L	DMTF1_uc003uii.2_Silent_p.L225L|DMTF1_uc003uij.2_Silent_p.L225L|DMTF1_uc011khb.1_Silent_p.L403L|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Silent_p.L491L|DMTF1_uc003uin.2_Silent_p.L225L	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	491	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for transcriptional activation (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					CAGTGGAACACTACAGACATT	0.378000													4	38					0	0	1	0	0
STEAP4	79689	broad.mit.edu	37	7	87913314	87913314	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:87913314C>T	uc003ujs.2	-	2	376	c.271G>A	c.(271-273)GAA>AAA	p.E91K	STEAP4_uc010lek.2_Missense_Mutation_p.E91K|STEAP4_uc003ujt.2_Missense_Mutation_p.E91K	NM_024636	NP_078912	Q687X5	STEA4_HUMAN	tumor necrosis factor, alpha-induced protein 9	91					fat cell differentiation|ion transport|iron ion homeostasis	Golgi membrane|integral to membrane|plasma membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	Esophageal squamous(14;0.00802)					TCAGTTAATTCTGTGAGAAAA	0.393000													44	73					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963320	88963320	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:88963320G>A	uc011khi.1	+	4	1562	c.1024G>A	c.(1024-1026)GAA>AAA	p.E342K		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	342						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TACCAGCAGAGAAAAAGAAAC	0.353000										HNSCC(36;0.09)			3	19					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963433	88963433	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:88963433G>A	uc011khi.1	+	4	1675	c.1137G>A	c.(1135-1137)AGG>AGA	p.R379R		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	379						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GTGATGCCAGGATATCTGAAT	0.388000										HNSCC(36;0.09)			5	34					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88965860	88965860	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:88965860C>T	uc011khi.1	+	4	4102	c.3564C>T	c.(3562-3564)GCC>GCT	p.A1188A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1188						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GGCCTACTGCCTTCTCTCCGG	0.488000										HNSCC(36;0.09)			13	74					0	0	1	0	0
KRIT1	889	broad.mit.edu	37	7	91864912	91864912	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:91864912G>A	uc003ulq.1	-	6	705	c.534C>T	c.(532-534)TTC>TTT	p.F178F	KRIT1_uc010lev.1_5'UTR|KRIT1_uc003ulr.1_Silent_p.F178F|KRIT1_uc003uls.1_Silent_p.F178F|KRIT1_uc003ult.1_Silent_p.F178F|KRIT1_uc003ulu.1_Silent_p.F178F|KRIT1_uc003ulv.1_Silent_p.F178F	NM_194456	NP_919438	O00522	KRIT1_HUMAN	krev interaction trapped 1 isoform 1	178					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			ovary(2)|lung(1)	3	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GAGAAGGTCGGAATAAAGCTG	0.388000									Familial_Cerebral_Cavernous_Angioma				4	49					0	0	1	0	0
C7orf64	84060	broad.mit.edu	37	7	92158808	92158808	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:92158808G>A	uc003ulz.2	+	2	171	c.130G>A	c.(130-132)GAA>AAA	p.E44K	PEX1_uc003uly.2_5'Flank|PEX1_uc011khr.1_5'Flank|PEX1_uc010ley.2_5'Flank|PEX1_uc011khs.1_5'Flank|C7orf64_uc011khu.1_Missense_Mutation_p.E44K|C7orf64_uc003uma.2_Missense_Mutation_p.E44K	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	44							nucleotide binding			ovary(2)	2						AATCAATTTGGAATCTCAGTA	0.353000													12	69					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762533	92762533	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:92762533C>T	uc003umh.1	-	5	3968	c.2752G>A	c.(2752-2754)GAA>AAA	p.E918K	SAMD9L_uc003umj.1_Missense_Mutation_p.E918K|SAMD9L_uc003umi.1_Missense_Mutation_p.E918K|SAMD9L_uc010lfb.1_Missense_Mutation_p.E918K|SAMD9L_uc003umk.1_Missense_Mutation_p.E918K|SAMD9L_uc010lfc.1_Missense_Mutation_p.E918K|SAMD9L_uc010lfd.1_Missense_Mutation_p.E918K|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	918										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGTTGTGCTTCCTTGCTGTCA	0.338000													4	26					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94035563	94035563	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:94035563G>A	uc003ung.1	+	12	1013	c.542G>A	c.(541-543)GGA>GAA	p.G181E	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfh.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	181			Missing (in OI4).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TCCTTTCAGGGACACAATGGT	0.368000										HNSCC(75;0.22)			8	72					0	0	1	0	0
PON3	5446	broad.mit.edu	37	7	94993240	94993240	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:94993240C>T	uc003unt.2	-	6	655	c.630G>A	c.(628-630)AGG>AGA	p.R210R	PON1_uc011kih.1_Intron|PON3_uc011kii.1_Silent_p.R258R	NM_000940	NP_000931	Q15166	PON3_HUMAN	paraoxonase 3	210					aromatic compound catabolic process|carboxylic acid catabolic process|response to external stimulus	extracellular space	aryldialkylphosphatase activity|arylesterase activity|metal ion binding|protein homodimerization activity			ovary(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0151)			CTTTAACCTCCCTTGGGCTGT	0.438000													24	187					0	0	1	0	0
TMEM130	222865	broad.mit.edu	37	7	98445848	98445848	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:98445848G>A	uc003upo.2	-	8	1328	c.1139C>T	c.(1138-1140)TCC>TTC	p.S380F	TMEM130_uc011kiq.1_Intron|TMEM130_uc011kir.1_Intron|TMEM130_uc003upn.2_Intron	NM_001134450	NP_001127922	Q8N3G9	TM130_HUMAN	transmembrane protein 130 isoform a	380	Cytoplasmic (Potential).					Golgi membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(62;4.05e-09)|all_epithelial(64;2.62e-09)|Lung NSC(181;0.01)|all_lung(186;0.0115)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGACATGGGGGAAAAGTCAAA	0.567000													21	27					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98508852	98508852	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:98508852C>T	uc003upp.2	+	17	2174	c.1965C>T	c.(1963-1965)GTC>GTT	p.V655V	TRRAP_uc011kis.1_Silent_p.V655V|TRRAP_uc003upr.2_Silent_p.V347V	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	655					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAACTACGGTCCCTTATATGG	0.358000													10	58					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98574593	98574593	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:98574593C>T	uc003upp.2	+	55	8467	c.8258C>T	c.(8257-8259)TCC>TTC	p.S2753F	TRRAP_uc011kis.1_Missense_Mutation_p.S2735F|TRRAP_uc003upr.2_Missense_Mutation_p.S2452F	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2753	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GAGCTTTACTCCCTGTTACAA	0.483000													9	128					0	0	1	0	0
CYP3A43	64816	broad.mit.edu	37	7	99447299	99447299	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:99447299C>T	uc003urx.1	+	7	755	c.652C>T	c.(652-654)CCC>TCC	p.P218S	CYP3A43_uc003ury.1_Missense_Mutation_p.P218S|CYP3A43_uc003urz.1_Missense_Mutation_p.P218S|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Intron|CYP3A43_uc003usb.1_Missense_Mutation_p.S80F	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	218			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TTTTTTGGATCCCTTTTTACT	0.229000													4	30					0	0	1	0	0
OR2AE1	81392	broad.mit.edu	37	7	99474348	99474348	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:99474348G>A	uc003usc.1	-	1	309	c.309C>T	c.(307-309)CTC>CTT	p.L103L		NM_001005276	NP_001005276	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					GACACAAATAGAGGAAGTGCT	0.468000													12	85					0	0	1	0	0
AZGP1	563	broad.mit.edu	37	7	99565827	99565827	+	Silent	SNP	C	T	T	rs150096066	by1000genomes	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:99565827C>T	uc003ush.2	-	3	608	c.564G>A	c.(562-564)GCG>GCA	p.A188A		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	188					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TCCGCAGAGTCGCAGGGCACT	0.552000													16	128					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100187827	100187827	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:100187827A>G	uc003uvm.1	+	3	462	c.169A>G	c.(169-171)AGA>GGA	p.R57G	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Missense_Mutation_p.R57G|FBXO24_uc003uvn.1_Intron|uc011kjy.1_Intron|FBXO24_uc011kjz.1_Missense_Mutation_p.R95G|FBXO24_uc011kka.1_Missense_Mutation_p.R45G	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	57	F-box.					ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CCTCCCAGTCAGAGACCTTGT	0.602000													5	64					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100490864	100490864	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:100490864G>A	uc003uxd.2	-	1	1146	c.990C>T	c.(988-990)TTC>TTT	p.F330F	ACHE_uc003uxe.2_Silent_p.F330F|ACHE_uc003uxf.2_Silent_p.F330F|ACHE_uc003uxg.2_Silent_p.F330F|ACHE_uc003uxh.2_Silent_p.F330F|ACHE_uc003uxi.2_Silent_p.F330F|ACHE_uc003uxj.1_Silent_p.F449F	NM_000665	NP_000656	P22303	ACES_HUMAN	acetylcholinesterase isoform E4-E6 precursor	330					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			skin(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	CCACAGGCACGAAGGAGAACC	0.597000													11	56					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685682	100685682	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:100685682C>T	uc003uxp.1	+	3	11038	c.10985C>T	c.(10984-10986)ACC>ATC	p.T3662I	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3662	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|58.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTTGACACCAGCACACCT	0.502000													34	224					0	0	1	0	0
PLOD3	8985	broad.mit.edu	37	7	100855617	100855617	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:100855617C>T	uc003uyd.2	-	10	1500	c.1044G>A	c.(1042-1044)CCG>CCA	p.P348P	PLOD3_uc010lhs.2_5'UTR	NM_001084	NP_001075	O60568	PLOD3_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase	348					protein modification process	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			ovary(1)|skin(1)	2	Lung NSC(181;0.168)|all_lung(186;0.215)				Succinic acid(DB00139)|Vitamin C(DB00126)	CCTGGAGCTGCGGCCAGGAGT	0.662000													18	140					0	0	1	0	0
LRWD1	222229	broad.mit.edu	37	7	102112964	102112964	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:102112964G>A	uc003uzn.2	+	13	1736	c.1598G>A	c.(1597-1599)CGG>CAG	p.R533Q	LRWD1_uc003uzo.2_Missense_Mutation_p.R381Q	NM_152892	NP_690852	Q9UFC0	LRWD1_HUMAN	leucine-rich repeats and WD repeat domain	533	WD 3.				chromatin modification|DNA-dependent DNA replication initiation|establishment of protein localization to chromatin|G1 phase of mitotic cell cycle	centromeric heterochromatin|nuclear origin of replication recognition complex|telomeric heterochromatin	chromatin binding|methyl-CpG binding|methylated histone residue binding			skin(1)	1						TGGGGGGGCCGGGGCAGCCAG	0.701000													3	13					0	0	1	0	0
LRRC17	10234	broad.mit.edu	37	7	102574760	102574760	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:102574760C>T	uc003vau.2	+	2	789	c.400C>T	c.(400-402)CTC>TTC	p.L134F	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.L134F	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	134	LRR 3.				bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						ACTCACCACCCTCTTACTGCA	0.443000													19	37					0	0	1	0	0
SLC26A5	375611	broad.mit.edu	37	7	103029793	103029793	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:103029793T>C	uc003vbz.2	-	13	1626	c.1390A>G	c.(1390-1392)ACC>GCC	p.T464A	SLC26A5_uc003vbt.1_Missense_Mutation_p.T464A|SLC26A5_uc003vbu.1_Missense_Mutation_p.T464A|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Intron|SLC26A5_uc003vby.2_Intron|SLC26A5_uc010liy.2_Intron	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	464	Extracellular (Potential).				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						ATTTTGCTGGTTCTCCAGAAA	0.413000													16	111					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103162526	103162527	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:103162526_103162527CC>TT	uc003vca.2	-	48	7770_7771	c.7610_7611GG>AA	c.(7609-7611)GGG>GAA	p.G2537E	RELN_uc010liz.2_Missense_Mutation_p.G2537E	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2537					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TACTCAATTTCCCTCCGTTCAC	0.520000													20	157					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103230099	103230099	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:103230099C>T	uc003vca.2	-	28	4249	c.4089G>A	c.(4087-4089)GGG>GGA	p.G1363G	RELN_uc010liz.2_Silent_p.G1363G	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1363					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTTCAAAGTCCCCTGTGTGAT	0.398000													16	133					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103244878	103244878	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:103244878C>T	uc003vca.2	-	23	3221	c.3061G>A	c.(3061-3063)GAG>AAG	p.E1021K	RELN_uc010liz.2_Missense_Mutation_p.E1021K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1021					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AAAGCCCACTCGTCTTGAGCT	0.502000													11	75					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103338393	103338393	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:103338393G>A	uc003vca.2	-	10	1210	c.1050C>T	c.(1048-1050)ATC>ATT	p.I350I	RELN_uc010liz.2_Silent_p.I350I	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	350					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGAATTGATGATCAAGATGT	0.463000													14	105					0	0	1	0	0
LRRN3	54674	broad.mit.edu	37	7	110764323	110764323	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:110764323A>G	uc003vft.3	+	4	2541	c.1495A>G	c.(1495-1497)ACT>GCT	p.T499A	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.T499A|LRRN3_uc003vfs.3_Missense_Mutation_p.T499A	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	499	Extracellular (Potential).|Ig-like C2-type.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TTGTATAGCAACTAACCTAGT	0.378000													6	49					0	0	1	0	0
GPR85	54329	broad.mit.edu	37	7	112724614	112724614	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:112724614G>A	uc010ljv.2	-	2	680	c.163C>T	c.(163-165)CCT>TCT	p.P55S	GPR85_uc003vgp.1_Missense_Mutation_p.P55S|GPR85_uc003vgq.2_Missense_Mutation_p.P55S|GPR85_uc010ljw.1_Missense_Mutation_p.P55S	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	55	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						AAGTAGTAAGGTGCTCTATGC	0.428000													13	132					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116398635	116398635	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:116398635C>T	uc003vij.2	+	9	2412	c.2225C>T	c.(2224-2226)CCC>CTC	p.P742L	MET_uc010lkh.2_Missense_Mutation_p.P742L|MET_uc011kng.1_Missense_Mutation_p.P742L|MET_uc011knh.1_Missense_Mutation_p.P742L|MET_uc011kni.1_Missense_Mutation_p.P742L|MET_uc011knj.1_Missense_Mutation_p.P312L	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	742	Extracellular (Potential).|IPT/TIG 3.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CGTGAAGATCCCATTGTCTAT	0.368000			Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				6	48					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117180273	117180273	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:117180273G>A	uc003vjd.2	+	8	1121	c.989G>A	c.(988-990)GGA>GAA	p.G330E	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	330	ABC transmembrane type-1 1.|Extracellular (Potential).				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CTAATCAAAGGAATCATCCTC	0.463000									Cystic_Fibrosis				10	91					0	0	1	0	0
TAS2R16	50833	broad.mit.edu	37	7	122635653	122635653	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:122635653G>A	uc003vkl.1	-	1	102	c.36C>T	c.(34-36)ATC>ATT	p.I12I		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	12	Helical; Name=1; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						GCACATAGATGATCATGAAGA	0.458000													6	46					0	0	1	0	0
IQUB	154865	broad.mit.edu	37	7	123152189	123152189	+	Missense_Mutation	SNP	G	A	A	rs140652989		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:123152189G>A	uc003vkn.2	-	2	783	c.206C>T	c.(205-207)TCA>TTA	p.S69L	IQUB_uc003vko.2_Missense_Mutation_p.S69L|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Missense_Mutation_p.S69L|IQUB_uc003vkq.2_Missense_Mutation_p.S69L	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	69										ovary(3)|large_intestine(1)	4						TTCCAGGCTTGAAAAGCTTTG	0.413000													21	128					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123264837	123264837	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:123264837C>T	uc003vku.1	+	8	958	c.666C>T	c.(664-666)CAC>CAT	p.H222H	ASB15_uc003vkv.1_Silent_p.H222H|ASB15_uc003vkw.1_Silent_p.H222H	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	222	ANK 4.				intracellular signal transduction					skin(2)|lung(1)	3						AGTATGGTCACTGTGACGTGT	0.468000											OREG0018282	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	39					0	0	1	0	0
ASB15	142685	broad.mit.edu	37	7	123270074	123270074	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:123270074C>T	uc003vku.1	+	11	1787	c.1495C>T	c.(1495-1497)CGT>TGT	p.R499C	ASB15_uc003vkw.1_Missense_Mutation_p.R499C	NM_080928	NP_563616	Q8WXK1	ASB15_HUMAN	ankyrin repeat and SOCS box-containing 15	499					intracellular signal transduction					skin(2)|lung(1)	3						CAGAGTTACTCGTGTACTAAT	0.358000													20	192					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123593980	123593980	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:123593980C>T	uc003vld.2	+	4	758	c.356C>T	c.(355-357)TCC>TTC	p.S119F	SPAM1_uc003vle.2_Missense_Mutation_p.S119F|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.S119F|SPAM1_uc010lku.2_Missense_Mutation_p.S119F	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	119					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	CAGAAGATTTCCTTACAAGAC	0.388000													14	84					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126542709	126542709	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:126542709C>T	uc003vlr.2	-	5	1354	c.1043G>A	c.(1042-1044)CGA>CAA	p.R348Q	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.R348Q|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.R69Q	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	348	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GGCAAGAGTTCGGCTTCTAAA	0.343000										HNSCC(24;0.065)			4	60					0	0	1	0	0
LOC407835	407835	broad.mit.edu	37	7	128766635	128766635	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:128766635C>T	uc003voo.2	+	1	311	c.64C>T	c.(64-66)CCG>TCG	p.P22S		NR_002144				SubName: Full=cDNA FLJ35806 fis, clone TESTI2005987, highly similar to Dual specificity mitogen-activated protein kinase kinase 2 (EC 2.7.12.2); SubName: Full=Mitogen-activated protein kinase kinase 2, isoform CRA_d;												0						CGCCGAGGGCCCGTCCCCAAC	0.697000													6	46					0	0	1	0	0
CPA1	1357	broad.mit.edu	37	7	130021621	130021621	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:130021621G>A	uc003vpx.2	+	3	370	c.298G>A	c.(298-300)GAG>AAG	p.E100K	CPA1_uc011kpf.1_Missense_Mutation_p.E12K|CPA1_uc003vpw.2_Intron	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	100					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GCTGGACGAGGAGCAGGAGCA	0.622000											OREG0018314	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	86					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131831326	131831326	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:131831326C>T	uc003vra.3	-	28	5227	c.4998G>A	c.(4996-4998)GGG>GGA	p.G1666G	PLXNA4_uc003vqz.3_5'Flank	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1666	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TCCCCCGGTCCCCCTCCTTCT	0.577000													70	416					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131831359	131831359	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:131831359C>T	uc003vra.3	-	28	5194	c.4965G>A	c.(4963-4965)GTG>GTA	p.V1655V	PLXNA4_uc003vqz.3_5'Flank	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1655	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CGTGGTTCTTCACTAGGTGCC	0.572000													30	400					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131912288	131912289	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:131912288_131912289CC>TT	uc003vra.3	-	7	2032_2033	c.1803_1804GG>AA	c.(1801-1806)ATGGAT>ATAAAT	p.601_602MD>IN		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	601_602	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ACCAGCCCATCCATCTCTGACA	0.609000													9	108					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192811	132192811	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:132192811G>A	uc003vra.3	-	2	871	c.642C>T	c.(640-642)TTC>TTT	p.F214F	PLXNA4_uc003vrc.2_Silent_p.F214F|PLXNA4_uc003vrb.2_Silent_p.F214F	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	214	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AGACGTACGCGAACATGCCAT	0.502000													22	168					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132193002	132193002	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:132193002C>T	uc003vra.3	-	2	680	c.451G>A	c.(451-453)GAG>AAG	p.E151K	PLXNA4_uc003vrc.2_Missense_Mutation_p.E151K|PLXNA4_uc003vrb.2_Missense_Mutation_p.E151K	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	151	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGATAAGGCTCCCCCAGCTTG	0.532000													17	78					0	0	1	0	0
LRGUK	136332	broad.mit.edu	37	7	133827912	133827912	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:133827912C>T	uc003vrm.1	+	4	601	c.585C>T	c.(583-585)CTC>CTT	p.L195L		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	195	LRR 4.						ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						CCAAAAACCTCAAGGTAGACT	0.323000													7	94					0	0	1	0	0
AKR1B1	231	broad.mit.edu	37	7	134134532	134134532	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:134134532G>A	uc003vrp.1	-	4	443	c.369C>T	c.(367-369)TTC>TTT	p.F123F	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	123					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	CATCCAATGGGAAAAATTCCT	0.468000													23	262					0	0	1	0	0
SLC13A4	26266	broad.mit.edu	37	7	135378895	135378895	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:135378895C>T	uc003vta.2	-	10	1797	c.1108G>A	c.(1108-1110)GGA>AGA	p.G370R	SLC13A4_uc003vtb.2_Missense_Mutation_p.G371R	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	370						integral to plasma membrane	sodium:sulfate symporter activity				0						CTAATGTCTCCCAGTTTTTCA	0.458000													11	88					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137761356	137761356	+	Missense_Mutation	SNP	C	T	T	rs148732404		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:137761356C>T	uc003vtz.2	+	1	161	c.92C>T	c.(91-93)TCG>TTG	p.S31L	AKR1D1_uc011kqb.1_Missense_Mutation_p.S31L|AKR1D1_uc011kqc.1_Intron|AKR1D1_uc011kqd.1_Intron|AKR1D1_uc011kqe.1_Missense_Mutation_p.S31L|AKR1D1_uc011kqf.1_Missense_Mutation_p.S31L	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	31					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						GAACCTAAATCGGTAAGCTTA	0.383000													3	44					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137792289	137792289	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:137792289A>G	uc003vtz.2	+	7	887	c.818A>G	c.(817-819)AAA>AGA	p.K273R	AKR1D1_uc011kqe.1_Missense_Mutation_p.K273R|AKR1D1_uc011kqf.1_Missense_Mutation_p.K232R|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	273	NADP.				androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						GTCATTCCTAAAAGCTTTAAT	0.363000													19	105					0	0	1	0	0
ZC3HAV1L	92092	broad.mit.edu	37	7	138713577	138713577	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:138713577G>A	uc003vum.1	-	3	643	c.631C>T	c.(631-633)CAT>TAT	p.H211Y		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	211											0						ATAAGCTGATGGGACCGTTTG	0.418000													6	40					0	0	1	0	0
CLEC2L	154790	broad.mit.edu	37	7	139226793	139226793	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:139226793G>A	uc010lnd.2	+	4	459	c.459G>A	c.(457-459)AGG>AGA	p.R153R		NM_001080511	NP_001073980	P0C7M8	CLC2L_HUMAN	C-type lectin domain family 2, member L	153	C-type lectin.					integral to membrane	sugar binding				0	Melanoma(164;0.233)					TCACGCGGAGGGAGCCCTGGA	0.552000													4	35					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453137	+	Missense_Mutation	DNP	AC	TT	TT	rs121913378		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:140453136_140453137AC>TT	uc003vwc.3	-	15	1859_1860	c.1798_1799GT>AA	c.(1798-1800)GTG>AAG	p.V600K		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAGA	0.366000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)|V600M(IGR1_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				23	46					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673182	141673182	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:141673182T>C	uc003vwx.1	-	1	392	c.308A>G	c.(307-309)AAC>AGC	p.N103S		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	103	Helical; Name=3; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					GTTGGCTTGGTTTGCAATCAT	0.522000													13	129					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141731583	141731583	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:141731583G>A	uc003vwy.2	+	13	1628	c.1574G>A	c.(1573-1575)GGA>GAA	p.G525E		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	525	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GAGTTTGATGGAATCTGGATT	0.378000													9	64					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141797419	141797419	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:141797419C>T	uc003vwy.2	+	43	5085	c.5031C>T	c.(5029-5031)TTC>TTT	p.F1677F		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1677	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTGCATATTTCCCTAGAGCCC	0.299000													12	72					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141805639	141805639	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:141805639G>A	uc003vwy.2	+	48	5576	c.5522G>A	c.(5521-5523)AGA>AAA	p.R1841K		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1841	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTGACTGACAGAAACATCAGC	0.368000													7	112					0	0	1	0	0
TRY6	154754	broad.mit.edu	37	7	142478857	142478857	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142478857C>T	uc011ksq.1	+	1	101	c.18C>T	c.(16-18)ATC>ATT	p.I6I	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|uc003wan.1_Intron|TRY6_uc011kso.1_Intron|TRY6_uc011ksr.1_5'Flank	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						CACTCCTGATCCTTGCCTTTG	0.577000													16	73					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142565796	142565796	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142565796G>A	uc011kst.1	+	13	2694	c.1907G>A	c.(1906-1908)AGC>AAC	p.S636N	EPHB6_uc011ksu.1_Missense_Mutation_p.S636N|EPHB6_uc003wbs.2_Missense_Mutation_p.S344N|EPHB6_uc003wbt.2_Missense_Mutation_p.S110N|EPHB6_uc003wbu.2_Missense_Mutation_p.S344N|EPHB6_uc003wbv.2_5'UTR	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	636	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CAGCAATACAGCAGCCCAGGT	0.627000													4	21					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142575760	142575760	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142575760G>A	uc003wbx.1	-	2	364	c.148C>T	c.(148-150)CTT>TTT	p.L50F	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_5'UTR	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	50	ANK 1.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GCAGCTAGAAGGAGAGGAGAC	0.488000													14	56					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142640047	142640047	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142640047G>A	uc003wcb.2	-	17	2066	c.1856C>T	c.(1855-1857)CCA>CTA	p.P619L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	619	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GCTAGGTAATGGAAAGGCAGC	0.547000													26	150					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142723868	142723868	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142723868G>A	uc003wcc.1	-	1	352	c.352C>T	c.(352-354)CGT>TGT	p.R118C		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	118	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					GCCACATAACGGTCCACAGCC	0.448000													45	54					0	0	1	0	0
OR9A2	135924	broad.mit.edu	37	7	142724186	142724186	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142724186G>A	uc003wcc.1	-	1	34	c.34C>T	c.(34-36)CAC>TAC	p.H12Y		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					CCTAGAAGGTGGAATTCAGTG	0.423000													14	63					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750118	142750118	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142750118C>T	uc011ksv.1	+	1	681	c.681C>T	c.(679-681)CCC>CCT	p.P227P		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TGCGGATCCCCTCTGCCAGCA	0.537000													35	224					0	0	1	0	0
OR6V1	346517	broad.mit.edu	37	7	142750145	142750145	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142750145C>T	uc011ksv.1	+	1	708	c.708C>T	c.(706-708)TTC>TTT	p.F236F		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	236	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					AGAAGGCTTTCTCCACTTGCG	0.547000													13	216					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880600	142880600	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142880600C>T	uc011ksw.1	+	1	89	c.89C>T	c.(88-90)TCG>TTG	p.S30L		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	30	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					AGTGAATTGTCGCCATTTCTC	0.418000													7	44					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880680	142880680	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142880680G>A	uc011ksw.1	+	1	169	c.169G>A	c.(169-171)GCT>ACT	p.A57T		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	57	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					TTTCATCATGGCTATACATGC	0.413000													11	68					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142881207	142881207	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142881207C>T	uc011ksw.1	+	1	696	c.696C>T	c.(694-696)ATC>ATT	p.I232I		NM_176881	NP_795362	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	232	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1	Melanoma(164;0.059)					CCCTGCTGATCCTCTCTCTCA	0.517000													29	134					0	0	1	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919729	142919729	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:142919729C>T	uc011ksx.1	+	1	558	c.558C>T	c.(556-558)TTC>TTT	p.F186F		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	186	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					AGAAGTACTTCTCTGAGACCA	0.468000													20	98					0	0	1	0	0
ZYX	7791	broad.mit.edu	37	7	143085406	143085406	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:143085406C>T	uc003wcw.2	+	6	1273	c.1118C>T	c.(1117-1119)CCT>CTT	p.P373L	ZYX_uc011ktd.1_Missense_Mutation_p.P216L|ZYX_uc003wcx.2_Missense_Mutation_p.P373L|ZYX_uc011kte.1_Missense_Mutation_p.P342L|ZYX_uc011ktf.1_Missense_Mutation_p.P216L	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	373					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					ATGGAGCATCCTCAGAGGCAG	0.672000													14	58					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143140577	143140577	+	Missense_Mutation	SNP	C	T	T	rs144050978		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:143140577C>T	uc011ktg.1	+	1	32	c.32C>T	c.(31-33)TCG>TTG	p.S11L	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	11	Helical; Name=1; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					CTAGGATCTTCGGTGACTGAC	0.498000													31	186					0	0	1	0	0
OR2F2	135948	broad.mit.edu	37	7	143632402	143632402	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:143632402C>T	uc011ktv.1	+	1	77	c.77C>T	c.(76-78)TCC>TTC	p.S26F		NM_001004685	NP_001004685	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	Melanoma(164;0.0903)					ACTCAGATATCCCTGTTTTCC	0.448000													38	249					0	0	1	0	0
OR2A2	442361	broad.mit.edu	37	7	143807206	143807206	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:143807206C>T	uc011ktz.1	+	1	531	c.531C>T	c.(529-531)TTC>TTT	p.F177F		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					ACCACCTCTTCTGTGAAATTC	0.512000													23	116					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146471471	146471471	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:146471471G>A	uc003weu.1	+	2	722	c.206G>A	c.(205-207)GGA>GAA	p.G69E		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	69	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AACAAGAGAGGAGGTAAGCCA	0.393000										HNSCC(39;0.1)			3	29					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146536847	146536847	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:146536847C>T	uc003weu.1	+	3	769	c.253C>T	c.(253-255)CTT>TTT	p.L85F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	85	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTATCAATGGCTTCAGGTTGA	0.468000										HNSCC(39;0.1)			13	81					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148080965	148080965	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:148080965G>A	uc003weu.1	+	22	4216	c.3700G>A	c.(3700-3702)GAT>AAT	p.D1234N	CNTNAP2_uc003wev.1_Missense_Mutation_p.D11N	NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1234	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTGGCACCTGGATCACCTGGA	0.413000										HNSCC(39;0.1)			9	23					0	0	1	0	0
ZNF398	57541	broad.mit.edu	37	7	148876608	148876608	+	Silent	SNP	C	T	T	rs143481615		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:148876608C>T	uc003wfl.2	+	6	1919	c.1644C>T	c.(1642-1644)TTC>TTT	p.F548F	ZNF398_uc011kul.1_Silent_p.F377F|ZNF398_uc011kum.1_Silent_p.F553F	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	548	C2H2-type 8.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			GCAAGAGCTTCATCCGCAAGC	0.602000													15	167					0	0	1	0	0
Unknown	0	broad.mit.edu	37	7	148964272	148964272	+	RNA	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:148964272G>A	uc003wfr.3	+	4		c.795G>A								Homo sapiens cDNA FLJ36716 fis, clone UTERU2010651.																		CAGGAGAAGGGGAATGAAGTA	0.572000													6	39					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149479387	149479387	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:149479387G>A	uc010lpk.2	+	14	1900	c.1900G>A	c.(1900-1902)GGA>AGA	p.G634R	SSPO_uc010lpl.1_Silent_p.Q27Q	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	634	VWFD 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGGGACTCAGGTAGCCTCTG	0.607000													4	13					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149490454	149490454	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:149490454G>A	uc010lpk.2	+	40	5930	c.5930G>A	c.(5929-5931)GGG>GAG	p.G1977E		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1977	VWFC 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CACCGTGTCGGGGAACGCTGG	0.677000													5	46					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149503132	149503132	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:149503132C>G	uc010lpk.2	+	59	8636	c.8636C>G	c.(8635-8637)ACG>AGG	p.T2879R		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2879	TSP type-1 8.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GACTGCAACACGCAGCCCTGC	0.632000													11	92					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149543252	149543252	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:149543252C>T	uc010lpn.2	+	3	341	c.149C>T	c.(148-150)GCC>GTC	p.A50V	ZNF862_uc003wgm.2_RNA	NM_001099220	NP_001092690	O60290	ZN862_HUMAN	zinc finger protein 862	50	KRAB 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			skin(1)	1						CCAACTGTTGCCAATCCTGAG	0.547000													5	39					0	0	1	0	0
ATP6V0E2	155066	broad.mit.edu	37	7	149576474	149576474	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:149576474C>T	uc003wgr.2	+	4	1370	c.419C>T	c.(418-420)TCG>TTG	p.S140L	ATP6V0E2_uc003wgs.2_Missense_Mutation_p.S117L|ATP6V0E2_uc003wgp.2_3'UTR|ATP6V0E2_uc003wgq.2_RNA|uc003wgt.1_5'Flank	NM_145230	NP_660265	Q8NHE4	VA0E2_HUMAN	ATPase, H+ transporting, V0 subunit isoform 1	Error:Variant_position_missing_in_Q8NHE4_after_alignment					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuole	ATPase activity, coupled to transmembrane movement of ions|hydrogen ion transmembrane transporter activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.00256)			ACAACCCCTTCGTCCGGACCC	0.622000													6	40					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164198	150164198	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:150164198G>A	uc003whj.2	+	2	742	c.412G>A	c.(412-414)GAT>AAT	p.D138N		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	138	GTP (Potential).					endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TCGGAAGGATGATTTGGGGGA	0.448000													8	63					0	0	1	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217651	150217651	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:150217651G>A	uc003whk.2	+	2	719	c.589G>A	c.(589-591)GAA>AAA	p.E197K		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	197							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCAGTGCAACGAAGGGGCTTA	0.443000													9	86					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150493504	150493505	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:150493504_150493505CC>AT	uc003wht.3	-	2	319_320	c.153_154GG>AT	c.(151-156)GGGGAC>GGATAC	p.D52Y	TMEM176B_uc003whu.3_Missense_Mutation_p.D52Y|TMEM176B_uc003whv.3_Missense_Mutation_p.D52Y|TMEM176B_uc003whw.3_Missense_Mutation_p.D52Y	NM_001101313	NP_001094783	Q3YBM2	T176B_HUMAN	transmembrane protein 176B isoform a	52					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGCACAGTGTCCCCAGGGTGAA	0.554000													15	78					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150649923	150649923	+	Missense_Mutation	SNP	C	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:150649923C>G	uc003wic.2	-	6	1160	c.1147G>C	c.(1147-1149)GAC>CAC	p.D383H	KCNH2_uc003wib.2_Missense_Mutation_p.D43H|KCNH2_uc011kux.1_Missense_Mutation_p.D287H|KCNH2_uc003wid.2_Missense_Mutation_p.D43H|KCNH2_uc003wie.2_Missense_Mutation_p.D383H	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	voltage-gated potassium channel, subfamily H,	383	Cytoplasmic (Potential).				blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity	p.D383N(1)		skin(3)|ovary(1)	4	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	GGCAGCACGTCGGCGCCCAGG	0.677000													7	111					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150931317	150931317	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:150931317C>T	uc003wjr.1	+	1	1733	c.220C>T	c.(220-222)CCC>TCC	p.P74S	CHPF2_uc003wjq.1_Missense_Mutation_p.P66S	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	74	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						CCGGATTGTCCCCTACTACAG	0.557000													20	97					0	0	1	0	0
XRCC2	7516	broad.mit.edu	37	7	152345844	152345844	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:152345844G>A	uc003wld.2	-	3	812	c.726C>T	c.(724-726)TCC>TCT	p.S242S		NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2	242					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		CATCTTGTTTGGAGAAAAACA	0.373000								Homologous_recombination					28	160					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154876077	154876077	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:154876077C>T	uc003wlu.1	+	2	1018	c.954C>T	c.(952-954)ATC>ATT	p.I318I		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	318	Extracellular (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TCCCCGCCATCTGGAAAAGCA	0.522000													30	162					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926687	157926687	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr7:157926687C>T	uc003wno.2	-	9	1359	c.1238G>A	c.(1237-1239)GGA>GAA	p.G413E	PTPRN2_uc003wnp.2_Missense_Mutation_p.G396E|PTPRN2_uc003wnq.2_Missense_Mutation_p.G413E|PTPRN2_uc003wnr.2_Missense_Mutation_p.G375E|PTPRN2_uc011kwa.1_Missense_Mutation_p.G436E	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	413	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGGGAGGGCTCCAGGTAAGAG	0.607000													23	91					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2813252	2813252	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:2813252C>T	uc011kwk.1	-	64	10246	c.9856G>A	c.(9856-9858)GAT>AAT	p.D3286N	CSMD1_uc011kwj.1_Missense_Mutation_p.D2615N|CSMD1_uc010lrg.2_Missense_Mutation_p.D1177N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3286	Sushi 28.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTCTCACATCCGCGTGTGCC	0.478000													20	109					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2830821	2830821	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:2830821C>T	uc011kwk.1	-	57	9134	c.8744G>A	c.(8743-8745)GGA>GAA	p.G2915E	CSMD1_uc011kwj.1_Missense_Mutation_p.G2244E|CSMD1_uc010lrg.2_Missense_Mutation_p.G925E	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2915	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGATTATTTCCTATTGAAAA	0.413000													49	192					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2876151	2876151	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:2876151G>A	uc011kwk.1	-	52	8270	c.7880C>T	c.(7879-7881)TCC>TTC	p.S2627F	CSMD1_uc011kwj.1_Missense_Mutation_p.S1956F|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2627	Extracellular (Potential).|Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGGGGGAAAGGAAAGGCTTCC	0.398000													25	104					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3263642	3263642	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:3263642C>T	uc011kwk.1	-	15	2566	c.2176G>A	c.(2176-2178)GAT>AAT	p.D726N	CSMD1_uc011kwj.1_Missense_Mutation_p.D118N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	726	Sushi 4.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACAAAGCCATCATCACAGTGG	0.527000													7	26					0	0	1	0	0
DEFB1	1672	broad.mit.edu	37	8	6728318	6728318	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:6728318C>T	uc003wqs.2	-	2	242	c.92G>A	c.(91-93)AGA>AAA	p.R31K		NM_005218	NP_005209	P60022	DEFB1_HUMAN	defensin, beta 1 preproprotein	31					chemotaxis|defense response to bacterium|G-protein coupled receptor protein signaling pathway|innate immune response	extracellular region					0			STAD - Stomach adenocarcinoma(24;0.0984)	COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.128)		ATGATCAGATCTGTGGCCAAG	0.488000													11	48					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17198902	17198902	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:17198902G>T	uc003wxm.2	-	6	941	c.702C>A	c.(700-702)GAC>GAA	p.D234E	MTMR7_uc003wxn.2_Missense_Mutation_p.D13E	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	234	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		CATAAACGAAGTCACTTCCTG	0.562000													11	63					9.31168e-06	9.36256e-06	1	1	0
GFRA2	2675	broad.mit.edu	37	8	21560352	21560352	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:21560352C>T	uc003wzu.1	-	7	1858	c.1183G>A	c.(1183-1185)GGG>AGG	p.G395R	GFRA2_uc003wzv.1_Missense_Mutation_p.G290R|GFRA2_uc003wzw.1_Missense_Mutation_p.G262R	NM_001495	NP_001486	O00451	GFRA2_HUMAN	GDNF family receptor alpha 2 isoform a	395						anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity				0				Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		ACACTGGTCCCCAAGCTGGTA	0.617000													5	41					0	0	1	0	0
XPO7	23039	broad.mit.edu	37	8	21844746	21844746	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:21844746C>T	uc003xaa.3	+	14	1774	c.1672C>T	c.(1672-1674)CGT>TGT	p.R558C	XPO7_uc010lti.2_Missense_Mutation_p.R567C|XPO7_uc010ltk.2_Missense_Mutation_p.R559C	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	558					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		TGAACAGTTTCGTAAGATCTA	0.483000													18	97					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24358356	24358356	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:24358356C>T	uc003xeb.2	+	19	2169	c.2056C>T	c.(2056-2058)CTT>TTT	p.L686F	ADAM7_uc003xec.2_Missense_Mutation_p.L458F	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	686	Helical; (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TATCGGAGTTCTTATACTATT	0.378000													7	66					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35647892	35647892	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:35647892C>T	uc003xjr.1	+	17	3001	c.2673C>T	c.(2671-2673)TTC>TTT	p.F891F	UNC5D_uc003xjs.1_Silent_p.F886F|UNC5D_uc003xju.1_Silent_p.F467F	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	891	Death.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TATCTTATTTCGCTACACAAA	0.393000													9	56					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36675228	36675228	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:36675228C>T	uc010lvw.2	+	10	1143	c.1056C>T	c.(1054-1056)TTC>TTT	p.F352F	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	352	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TGAGGAATTTCCTCCGCGACA	0.443000													14	79					0	0	1	0	0
DDHD2	23259	broad.mit.edu	37	8	38092070	38092070	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:38092070C>T	uc003xlb.2	+	3	756	c.379C>T	c.(379-381)CCC>TCC	p.P127S	DDHD2_uc003xla.2_Missense_Mutation_p.P127S|DDHD2_uc003xlc.2_Missense_Mutation_p.P127S|DDHD2_uc011lbl.1_5'UTR	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	127					lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TAAGTATGTTCCCTACTCGGA	0.398000													34	117					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39564406	39564406	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:39564406G>A	uc003xni.2	+	18	2000	c.2000G>A	c.(1999-2001)GGA>GAA	p.G667E	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.G643E	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	667	Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			ATTGATGATGGAAATTTTCAG	0.323000													8	63					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41566326	41566326	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:41566326C>T	uc003xok.2	-	17	2052	c.1968G>A	c.(1966-1968)TCG>TCA	p.S656S	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_5'Flank|ANK1_uc003xoi.2_Silent_p.S656S|ANK1_uc003xoj.2_Silent_p.S656S|ANK1_uc003xol.2_Silent_p.S656S|ANK1_uc003xom.2_Silent_p.S689S	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	656	ANK 19.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TGGCTTGTTTCGAGAGCAGCA	0.567000													39	176					0	0	1	0	0
CHRNB3	1142	broad.mit.edu	37	8	42586860	42586860	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:42586860C>T	uc003xpi.1	+	5	538	c.410C>T	c.(409-411)TCA>TTA	p.S137L		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	137	Extracellular (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ATCGTGAAATCAAACGGAACT	0.542000													11	52					0	0	1	0	0
CHRNB3	1142	broad.mit.edu	37	8	42587284	42587284	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:42587284C>T	uc003xpi.1	+	5	962	c.834C>T	c.(832-834)TTC>TTT	p.F278F		NM_000749	NP_000740	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta	278	Helical; (Potential).				synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)	1	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TGACAGTTTTCCTTTTAGTGA	0.408000													29	119					0	0	1	0	0
TCEA1	6917	broad.mit.edu	37	8	54912521	54912521	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:54912521G>A	uc003xru.2	-	3	539	c.216C>T	c.(214-216)TCC>TCT	p.S72S	TCEA1_uc003xrv.2_Silent_p.S51S|TCEA1_uc011ldw.1_Intron|TCEA1_uc003xrw.1_RNA	NM_006756	NP_006747	P23193	TCEA1_HUMAN	transcription elongation factor A 1 isoform 1	72	TFIIS N-terminal.				positive regulation of viral transcription|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|translation elongation factor activity|zinc ion binding				0		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;9.1e-07)|Epithelial(17;9.44e-05)|all cancers(17;0.000699)			ATTTTTTCCAGGATTTGATGA	0.333000			T	PLAG1	salivary adenoma								3	6					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55534779	55534779	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:55534779C>T	uc003xsd.1	+	3	866	c.718C>T	c.(718-720)CCT>TCT	p.P240S	RP1_uc011ldy.1_Missense_Mutation_p.P240S	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	240					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			ATACTTGCTTCCTGCTAGATT	0.463000													16	52					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538601	55538601	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:55538601C>T	uc003xsd.1	+	4	2307	c.2159C>T	c.(2158-2160)CCC>CTC	p.P720L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	720					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TCAGATAGTCCCCTTAAAGGA	0.348000													8	42					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55539604	55539605	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:55539604_55539605GG>AA	uc003xsd.1	+	4	3310_3311	c.3162_3163GG>AA	c.(3160-3165)CAGGAA>CAAAAA	p.E1055K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1055					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGTTTACCAGGAAATAAACCT	0.376000													14	71					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540140	55540140	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:55540140C>T	uc003xsd.1	+	4	3846	c.3698C>T	c.(3697-3699)TCC>TTC	p.S1233F	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1233					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CAAGGAATCTCCTCTTTGGAT	0.443000													22	94					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56725651	56725651	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:56725651C>T	uc003xsj.3	+	12	2800	c.2413C>T	c.(2413-2415)CTT>TTT	p.L805F	TGS1_uc010lyh.2_Silent_p.F631F	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	805	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TGTTTATTTTCTTCCAAGAAA	0.323000													6	41					0	0	1	0	0
PLAG1	5324	broad.mit.edu	37	8	57079506	57079506	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:57079506G>A	uc003xsq.3	-	3	1250	c.799C>T	c.(799-801)CTT>TTT	p.L267F	PLAG1_uc003xsr.3_Missense_Mutation_p.L267F|PLAG1_uc010lyi.2_Missense_Mutation_p.L267F|PLAG1_uc010lyj.2_Missense_Mutation_p.L185F	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	267	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			ATCACCGGAAGGAGCTCGTCT	0.438000			T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								31	138					0	0	1	0	0
SDR16C5	195814	broad.mit.edu	37	8	57214079	57214079	+	Missense_Mutation	SNP	T	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:57214079T>G	uc003xsy.1	-	7	1528	c.890A>C	c.(889-891)CAT>CCT	p.H297P	SDR16C5_uc010lyk.1_3'UTR|SDR16C5_uc010lyl.1_Missense_Mutation_p.H253P	NM_138969	NP_620419	Q8N3Y7	RDHE2_HUMAN	epidermal retinal dehydrogenase 2	297					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ATCCATTGCATGAAGGATGCC	0.383000													18	113					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57353902	57353902	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:57353902C>T	uc003xsz.2	-	2	814	c.733G>A	c.(733-735)GAA>AAA	p.E245K	PENK_uc003xta.3_Missense_Mutation_p.E245K	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	245					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TCGCCTTCTTCGTCGGAGGGC	0.498000													17	89					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354053	57354053	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:57354053C>T	uc003xsz.2	-	2	663	c.582G>A	c.(580-582)AAG>AAA	p.K194K	PENK_uc003xta.3_Silent_p.K194K	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	194					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GGGGGCTTCTCTTTAAGCCTC	0.527000													18	104					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62289311	62289311	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:62289311C>T	uc003xuh.2	+	3	927	c.603C>T	c.(601-603)ATC>ATT	p.I201I	CLVS1_uc003xug.2_3'UTR|CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Silent_p.I201I	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	201	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CACCTTCAATCCTTAAACTGG	0.378000													8	34					0	0	1	0	0
YTHDF3	253943	broad.mit.edu	37	8	64098919	64098919	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:64098919C>T	uc003xuy.2	+	5	666	c.350C>T	c.(349-351)CCA>CTA	p.P117L	YTHDF3_uc010lys.2_Missense_Mutation_p.P61L|YTHDF3_uc003xuz.2_Missense_Mutation_p.P61L|YTHDF3_uc003xva.2_Missense_Mutation_p.P61L|YTHDF3_uc011len.1_Missense_Mutation_p.P61L	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	117											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			AATACCCCTCCATTTCTTGGT	0.408000													7	30					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65527628	65527628	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:65527628G>A	uc003xvj.2	-	4	1216	c.1012C>T	c.(1012-1014)CCC>TCC	p.P338S		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	338					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AGGTGGATGGGAAATCCAGAC	0.443000													13	47					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65527679	65527679	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:65527679C>T	uc003xvj.2	-	4	1165	c.961G>A	c.(961-963)GAA>AAA	p.E321K		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	321					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				CGGTCAATTTCGTCACGCACT	0.488000													9	34					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68942750	68942751	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:68942750_68942751CC>TT	uc003xxv.1	+	6	589_590	c.562_563CC>TT	c.(562-564)CCA>TTA	p.P188L	PREX2_uc003xxu.1_Missense_Mutation_p.P188L|PREX2_uc011lez.1_Missense_Mutation_p.P123L	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	188	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GAAGCGGACTCCACGGAAACAC	0.455000													8	30					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69136817	69136817	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:69136817G>A	uc003xxv.1	+	39	4758	c.4731G>A	c.(4729-4731)GCG>GCA	p.A1577A		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1577					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AGAACACAGCGAAGAATTTGG	0.458000													8	53					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73850087	73850087	+	Missense_Mutation	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:73850087T>C	uc003xzb.2	+	3	3085	c.2497T>C	c.(2497-2499)TGC>CGC	p.C833R		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	833	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			CAGCCCAAATTGCTTTGCAGA	0.532000													22	72					0	0	1	0	0
PI15	51050	broad.mit.edu	37	8	75761470	75761470	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:75761470C>T	uc003yal.2	+	6	938	c.759C>T	c.(757-759)TAC>TAT	p.Y253Y	uc003yak.1_Intron|PI15_uc003yam.2_Silent_p.Y253Y	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	253						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			CGTCAAACTACCTGTACTGGT	0.378000													20	71					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766843	77766843	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:77766843G>A	uc003yav.2	+	10	7938	c.7551G>A	c.(7549-7551)CAG>CAA	p.Q2517Q	ZFHX4_uc003yau.1_Silent_p.Q2562Q|ZFHX4_uc003yaw.1_Silent_p.Q2517Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2517						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCCCCCTCAGGCCAGTTCCT	0.498000										HNSCC(33;0.089)			17	69					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767078	77767078	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:77767078G>A	uc003yav.2	+	10	8173	c.7786G>A	c.(7786-7788)GAA>AAA	p.E2596K	ZFHX4_uc003yau.1_Missense_Mutation_p.E2641K|ZFHX4_uc003yaw.1_Missense_Mutation_p.E2596K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2596	Homeobox 3.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TATTGCCCGCGAAGTCGGGCT	0.512000										HNSCC(33;0.089)			7	40					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87680323	87680323	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:87680323C>T	uc003ydx.2	-	5	613	c.567G>A	c.(565-567)TGG>TGA	p.W189*	CNGB3_uc010maj.2_Nonsense_Mutation_p.W51*	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	189	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TGACTTTGAACCACAACAGCC	0.368000													23	91					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93003922	93003922	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:93003922C>T	uc003yfd.2	-	6	1020	c.936G>A	c.(934-936)AGG>AGA	p.R312R	RUNX1T1_uc003yfc.1_Silent_p.R285R|RUNX1T1_uc003yfe.1_Silent_p.R275R|RUNX1T1_uc010mao.2_Silent_p.R285R|RUNX1T1_uc011lgi.1_Silent_p.R323R|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Silent_p.R275R	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	312					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GATAGGAGTCCCTGTAGTGGT	0.547000													26	106					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95392468	95392468	+	Silent	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:95392468A>G	uc003ygk.2	-	12	2250	c.2152T>C	c.(2152-2154)TTA>CTA	p.L718L	RAD54B_uc010may.1_Silent_p.L525L	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			TTTGAACTTAACAAAAAAATA	0.378000								Direct_reversal_of_damage|Homologous_recombination					9	41					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100733174	100733174	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:100733174C>T	uc003yiv.2	+	39	7135	c.7024C>T	c.(7024-7026)CCA>TCA	p.P2342S	VPS13B_uc003yiw.2_Missense_Mutation_p.P2317S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2342					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			ATGGAGATATCCAGAACCTAG	0.393000													11	49					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102585978	102585978	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:102585978G>A	uc010mbu.2	+	6	1147	c.817G>A	c.(817-819)GGA>AGA	p.G273R	GRHL2_uc011lhi.1_Missense_Mutation_p.G273R	NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	273						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			CCTCAACAAAGGACAGTTCTA	0.507000													17	52					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104955088	104955088	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:104955088C>T	uc003yls.2	+	12	2210	c.1969C>T	c.(1969-1971)CCC>TCC	p.P657S	RIMS2_uc003ylp.2_Missense_Mutation_p.P879S|RIMS2_uc003ylw.2_Missense_Mutation_p.P671S|RIMS2_uc003ylq.2_Missense_Mutation_p.P671S|RIMS2_uc003ylr.2_Missense_Mutation_p.P718S|RIMS2_uc003ylt.2_Missense_Mutation_p.P264S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	941					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding	p.P671S(1)		ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ATTGCCACTTCCCCACCCTTC	0.388000										HNSCC(12;0.0054)			12	37					0	0	1	0	0
DPYS	1807	broad.mit.edu	37	8	105459605	105459605	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:105459605C>T	uc003yly.3	-	3	679	c.550G>A	c.(550-552)GAA>AAA	p.E184K		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	184					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCTCCAATTTCCTTGCACCGA	0.443000													10	50					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110509206	110509206	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:110509206G>A	uc003yne.2	+	64	10490	c.10386G>A	c.(10384-10386)GGG>GGA	p.G3462G		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3462	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTTTATATGGGATCTATATGA	0.383000										HNSCC(38;0.096)			20	68					0	0	1	0	0
COLEC10	10584	broad.mit.edu	37	8	120114598	120114598	+	Missense_Mutation	SNP	G	A	A	rs142250367		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:120114598G>A	uc003yoo.2	+	4	401	c.304G>A	c.(304-306)GAA>AAA	p.E102K		NM_006438	NP_006429	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 precursor	102	Collagen-like.					collagen|cytoplasm	mannose binding	p.E102K(1)		ovary(2)|skin(1)	3	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			TGACAAAGGGGAAAAAGGTTT	0.249000													6	34					0	0	1	0	0
KCNQ3	3786	broad.mit.edu	37	8	133152354	133152354	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:133152354G>A	uc003ytj.2	-	11	1762	c.1537C>T	c.(1537-1539)CCC>TCC	p.P513S	KCNQ3_uc010mdt.2_Missense_Mutation_p.P513S	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	513					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTCAGGGTGGGGATCATGTCT	0.627000													25	102					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133919138	133919138	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:133919138C>T	uc003ytw.2	+	17	3881	c.3840C>T	c.(3838-3840)GCC>GCT	p.A1280A	TG_uc010mdw.2_Silent_p.A39A	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1280					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCCCCGGGCCTGCCAACGTG	0.642000													3	24					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139153542	139153542	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:139153542C>T	uc003yuy.2	-	17	3860	c.3689G>A	c.(3688-3690)CGG>CAG	p.R1230Q	FAM135B_uc003yux.2_Missense_Mutation_p.R1131Q|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1230										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GAACCGGGGCCGTGTGAGGAC	0.537000										HNSCC(54;0.14)			22	103					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164989	139164989	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:139164989C>T	uc003yuy.2	-	13	1900	c.1729G>A	c.(1729-1731)GAG>AAG	p.E577K	FAM135B_uc003yux.2_Missense_Mutation_p.E478K|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.E139K|FAM135B_uc003yvb.2_Missense_Mutation_p.E139K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	577										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTCCTACTCTCATGCTGAGCA	0.488000										HNSCC(54;0.14)			21	102					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139674277	139674277	+	Missense_Mutation	SNP	C	T	T	rs146190475	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:139674277C>T	uc003yvd.2	-	43	3683	c.3236G>A	c.(3235-3237)CGG>CAG	p.R1079Q	COL22A1_uc011ljo.1_Missense_Mutation_p.R359Q	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1079	Pro-rich.|Gly-rich.|Collagen-like 9.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ACTTACGTCCCGGCCGGCTGG	0.542000										HNSCC(7;0.00092)			14	62					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143998579	143998579	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:143998579C>T	uc003yxk.1	-	2	294	c.291G>A	c.(289-291)GTG>GTA	p.V97V		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	97					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCAGCTTCTCCACATCCTCCG	0.607000									Familial_Hyperaldosteronism_type_I				32	128					0	0	1	0	0
KIAA1432	57589	broad.mit.edu	37	9	5754865	5754865	+	Missense_Mutation	SNP	G	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:5754865G>C	uc003zji.2	+	14	1483	c.1390G>C	c.(1390-1392)GGC>CGC	p.G464R	KIAA1432_uc003zjh.2_Missense_Mutation_p.G464R|KIAA1432_uc003zjl.3_Missense_Mutation_p.G427R|KIAA1432_uc003zjj.1_Missense_Mutation_p.G6R	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	543						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CGTGACAGGTGGCTTAGCCTG	0.279000													20	77					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8319882	8319882	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:8319882G>A	uc003zkk.2	-	44	6330	c.5619C>T	c.(5617-5619)TTC>TTT	p.F1873F	PTPRD_uc003zkp.2_Silent_p.F1467F|PTPRD_uc003zkq.2_Silent_p.F1466F|PTPRD_uc003zkr.2_Silent_p.F1457F|PTPRD_uc003zks.2_Silent_p.F1466F|PTPRD_uc003zkl.2_Silent_p.F1864F|PTPRD_uc003zkm.2_Silent_p.F1860F|PTPRD_uc003zkn.2_Silent_p.F1462F|PTPRD_uc003zko.2_Silent_p.F1463F	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1873	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGACAGTCTGGAAGATATCTA	0.418000										TSP Lung(15;0.13)			6	47					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8341178	8341178	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:8341178G>A	uc003zkk.2	-	40	5749	c.5038C>T	c.(5038-5040)CCA>TCA	p.P1680S	PTPRD_uc003zkp.2_Missense_Mutation_p.P1274S|PTPRD_uc003zkq.2_Missense_Mutation_p.P1273S|PTPRD_uc003zkr.2_Missense_Mutation_p.P1264S|PTPRD_uc003zks.2_Missense_Mutation_p.P1273S|PTPRD_uc003zkl.2_Missense_Mutation_p.P1671S|PTPRD_uc003zkm.2_Missense_Mutation_p.P1667S|PTPRD_uc003zkn.2_Missense_Mutation_p.P1269S|PTPRD_uc003zko.2_Missense_Mutation_p.P1270S	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1680	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GATTCATATGGCATAATATTA	0.393000										TSP Lung(15;0.13)			18	118					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8389285	8389285	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:8389285C>T	uc003zkk.2	-	36	5044	c.4333G>A	c.(4333-4335)GAA>AAA	p.E1445K	PTPRD_uc003zkp.2_Missense_Mutation_p.E1039K|PTPRD_uc003zkq.2_Missense_Mutation_p.E1038K|PTPRD_uc003zkr.2_Missense_Mutation_p.E1029K|PTPRD_uc003zks.2_Missense_Mutation_p.E1038K|PTPRD_uc003zkl.2_Missense_Mutation_p.E1436K|PTPRD_uc003zkm.2_Missense_Mutation_p.E1432K|PTPRD_uc003zkn.2_Missense_Mutation_p.E1034K|PTPRD_uc003zko.2_Missense_Mutation_p.E1035K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1445	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTCCGTTGTTCCCATATCATT	0.403000										TSP Lung(15;0.13)			27	96					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8500899	8500899	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:8500899C>T	uc003zkk.2	-	23	2694	c.1983G>A	c.(1981-1983)GAG>GAA	p.E661E	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.E661E|PTPRD_uc003zkm.2_Silent_p.E648E|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	661	Fibronectin type-III 4.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTCCCAAAATCTCGTGAGGCT	0.463000										TSP Lung(15;0.13)			35	167					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8633356	8633356	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:8633356C>T	uc003zkk.2	-	13	1024	c.313G>A	c.(313-315)GGA>AGA	p.G105R	PTPRD_uc003zkp.2_Missense_Mutation_p.G105R|PTPRD_uc003zkq.2_Missense_Mutation_p.G105R|PTPRD_uc003zkr.2_Missense_Mutation_p.G105R|PTPRD_uc003zks.2_Missense_Mutation_p.G105R|PTPRD_uc003zkl.2_Missense_Mutation_p.G105R|PTPRD_uc003zkm.2_Missense_Mutation_p.G105R|PTPRD_uc003zkn.2_Missense_Mutation_p.G105R|PTPRD_uc003zko.2_Missense_Mutation_p.G105R|PTPRD_uc003zkt.1_Missense_Mutation_p.G105R	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	105	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTTATTTCTCCCACATTATTT	0.428000										TSP Lung(15;0.13)			11	62					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14722289	14722289	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:14722289C>T	uc003zlj.2	-	1	427	c.382G>A	c.(382-384)GAA>AAA	p.E128K		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	128					BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		TTGGCTTCTTCCCGAAGAGGA	0.507000													6	47					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14750162	14750162	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:14750162C>T	uc003zlm.2	-	30	6110	c.5520G>A	c.(5518-5520)AAG>AAA	p.K1840K	FREM1_uc010mic.2_RNA|FREM1_uc003zlk.2_Intron|FREM1_uc003zll.2_Silent_p.K376K	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1840					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		CAGCTTTTGTCTTTGTGCCAA	0.423000													27	93					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889747	18889747	+	Splice_Site	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:18889747G>A	uc003zne.3	+	25	4770	c.4643_splice	c.e25+1	p.R1548_splice	ADAMTSL1_uc003znf.3_Splice_Site_p.R249_splice	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GCCCTTCTCGGTGAGTGCAGC	0.647000													4	8					0	0	1	0	0
IFNA7	3444	broad.mit.edu	37	9	21202101	21202101	+	Missense_Mutation	SNP	G	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:21202101G>T	uc003zop.1	-	1	104	c.64C>A	c.(64-66)CTG>ATG	p.L22M	IFNA14_uc003zoo.1_Intron	NM_021057	NP_066401	P01567	IFNA7_HUMAN	interferon, alpha 7 precursor	22					blood coagulation|cell-cell signaling|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding				0				GBM - Glioblastoma multiforme(5;4.75e-197)|Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCACAGCCCAGAGAGCAGATG	0.507000													9	64					0.0692343	0.069318	1	1	0
IFNA16	3449	broad.mit.edu	37	9	21216966	21216966	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:21216966G>A	uc003zor.1	-	1	345	c.339C>T	c.(337-339)TTC>TTT	p.F113F	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	113					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TCAGTTGCTGGAAAAGTTCAA	0.473000													36	132					0	0	1	0	0
IFNA16	3449	broad.mit.edu	37	9	21216968	21216968	+	Missense_Mutation	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:21216968A>G	uc003zor.1	-	1	343	c.337T>C	c.(337-339)TTC>CTC	p.F113L	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	113					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AGTTGCTGGAAAAGTTCAATG	0.473000													37	128					0	0	1	0	0
LINGO2	158038	broad.mit.edu	37	9	27949509	27949509	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:27949509G>A	uc003zqu.1	-	2	1355	c.1161C>T	c.(1159-1161)ACC>ACT	p.T387T	LINGO2_uc010mjf.1_Silent_p.T387T|LINGO2_uc003zqv.1_Silent_p.T387T	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	387	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TCTCACGGATGGTGTCTGGGC	0.517000													6	48					0	0	1	0	0
KIAA1161	57462	broad.mit.edu	37	9	34371687	34371687	+	Silent	SNP	A	G	G			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:34371687A>G	uc003zue.3	-	3	1422	c.1255T>C	c.(1255-1257)TTA>CTA	p.L419L		NM_020702	NP_065753	Q6NSJ0	K1161_HUMAN	hypothetical protein LOC57462	419	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane	hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|breast(1)|central_nervous_system(1)	3			LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.126)		AGCGCAGGTAACCGGCCCGTG	0.682000													3	13					0	0	1	0	0
KIAA1539	80256	broad.mit.edu	37	9	35108110	35108110	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:35108110G>A	uc003zwl.2	-	3	487	c.162C>T	c.(160-162)TCC>TCT	p.S54S	KIAA1539_uc003zwm.2_Silent_p.S54S|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Silent_p.S54S|KIAA1539_uc003zwp.1_Silent_p.S54S|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	54						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CAGCCGGAGGGGAAAAGATGG	0.672000													3	26					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35381639	35381639	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:35381639C>T	uc003zwq.2	+	19	2623	c.2331C>T	c.(2329-2331)TAC>TAT	p.Y777Y	UNC13B_uc003zwr.2_Silent_p.Y777Y	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	777					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GGAAGGTGTACTTTGATGAGA	0.512000													34	187					0	0	1	0	0
SHB	6461	broad.mit.edu	37	9	37955927	37955927	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:37955927C>T	uc004aax.2	-	4	1747	c.1179G>A	c.(1177-1179)GGG>GGA	p.G393G		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	393	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		CTCCTAGGATCCCGCAGAACT	0.592000													3	28					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39109157	39109157	+	Nonsense_Mutation	SNP	G	A	A	rs148747631	by1000genomes	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:39109157G>A	uc004abi.2	-	15	2604	c.2365C>T	c.(2365-2367)CAG>TAG	p.Q789*	CNTNAP3_uc004abj.2_Nonsense_Mutation_p.Q788*|CNTNAP3_uc011lqr.1_RNA|CNTNAP3_uc004abk.1_Nonsense_Mutation_p.Q789*	NM_033655	NP_387504	Q9BZ76	CNTP3_HUMAN	cell recognition molecule CASPR3 precursor	789	Fibrinogen C-terminal.|Extracellular (Potential).				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CACTACTTACGATCTCCGCGG	0.448000													5	46					0	0	1	0	0
FXN	2395	broad.mit.edu	37	9	71668065	71668065	+	Silent	SNP	T	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:71668065T>C	uc004aha.2	+	3	493	c.273T>C	c.(271-273)GAT>GAC	p.D91D	FXN_uc011lrr.1_Silent_p.D91D|FXN_uc004agz.2_Silent_p.D91D	NM_000144	NP_000135	Q16595	FRDA_HUMAN	frataxin isoform 1 preproprotein	91					cellular iron ion homeostasis|cellular response to hydrogen peroxide|heme biosynthetic process|ion transport|iron incorporation into metallo-sulfur cluster|negative regulation of apoptosis|negative regulation of release of cytochrome c from mitochondria|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity|protein autoprocessing|regulation of ferrochelatase activity|response to iron ion	cytosol|mitochondrial matrix	2 iron, 2 sulfur cluster binding|ferric iron binding|ferrous iron binding|ferroxidase activity|iron chaperone activity|protein binding				0						GCTCTCTAGATGAGACCACCT	0.343000													5	46					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78686660	78686660	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:78686660G>A	uc004ajz.2	+	7	1278	c.740G>A	c.(739-741)GGA>GAA	p.G247E	PCSK5_uc004ajy.2_Missense_Mutation_p.G247E|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	247	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						ATGCTGGACGGAGATGTCACG	0.522000													28	131					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78749103	78749103	+	Nonsense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:78749103G>A	uc004ajz.2	+	10	1825	c.1287G>A	c.(1285-1287)TGG>TGA	p.W429*	PCSK5_uc004ajy.2_Nonsense_Mutation_p.W429*|PCSK5_uc004aka.2_Intron	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	429	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CTAATGACTGGAAAACCAATG	0.423000													7	32					0	0	1	0	0
GCNT1	2650	broad.mit.edu	37	9	79117954	79117954	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:79117954G>A	uc010mpf.2	+	3	998	c.657G>A	c.(655-657)ATG>ATA	p.M219I	GCNT1_uc010mpg.2_Missense_Mutation_p.M219I|GCNT1_uc010mph.2_Missense_Mutation_p.M219I|GCNT1_uc004akf.3_Missense_Mutation_p.M219I|GCNT1_uc010mpi.2_Missense_Mutation_p.M219I|GCNT1_uc004akh.3_Missense_Mutation_p.M219I	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	219	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						TTTGTGGTATGGATTTTCCCA	0.428000													15	51					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79318766	79318766	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:79318766C>T	uc010mpk.2	-	9	7887	c.7763G>A	c.(7762-7764)GGA>GAA	p.G2588E	PRUNE2_uc004akj.3_Missense_Mutation_p.G41E|PRUNE2_uc010mpl.1_Missense_Mutation_p.G41E	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	2588					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						TAACTGAGTTCCCTGCAGCCC	0.428000													13	66					0	0	1	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608425	84608425	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:84608425G>A	uc004amn.2	+	4	3087	c.3040G>A	c.(3040-3042)GAG>AAG	p.E1014K		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1014						integral to membrane					0						TGACCTTATAGAGACAGATTC	0.488000													34	158					0	0	1	0	0
FAM75C1	441452	broad.mit.edu	37	9	90537092	90537092	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:90537092C>T	uc010mqi.2	+	4	2299	c.2270C>T	c.(2269-2271)TCA>TTA	p.S757L	FAM75C1_uc004apq.3_Missense_Mutation_p.S740L	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						ATCCCATCTTCAAATGATCAT	0.572000													11	39					0	0	1	0	0
SPIN1	10927	broad.mit.edu	37	9	91041469	91041469	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:91041469C>T	uc010mqj.2	+	2	515	c.15C>T	c.(13-15)TTC>TTT	p.F5F	SPIN1_uc004apy.2_Silent_p.F5F|SPIN1_uc004apz.2_Silent_p.F5F|SPIN1_uc010mqk.2_Silent_p.F5F	NM_006717	NP_006708	Q9Y657	SPIN1_HUMAN	spindlin	5					cell cycle|gamete generation|multicellular organismal development	nucleus	methylated histone residue binding				0						AGACCCCATTCGGAAAGACAC	0.383000													5	36					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94493428	94493428	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:94493428C>T	uc004arj.1	-	7	1146	c.947G>A	c.(946-948)TGC>TAC	p.C316Y	ROR2_uc004ari.1_Missense_Mutation_p.C176Y|ROR2_uc004ark.2_Missense_Mutation_p.C316Y	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	316	Extracellular (Potential).|Kringle.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GCCGTTATAGCACTGATGGTC	0.532000													27	101					0	0	1	0	0
WNK2	65268	broad.mit.edu	37	9	96021498	96021498	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:96021498G>A	uc004ati.1	+	11	2668	c.2668G>A	c.(2668-2670)GCC>ACC	p.A890T	WNK2_uc011lud.1_Missense_Mutation_p.A890T|WNK2_uc004atj.2_Missense_Mutation_p.A890T|WNK2_uc004atk.2_Missense_Mutation_p.A527T|WNK2_uc010mrc.1_Missense_Mutation_p.A838T	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	890					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						GCTGGCCGTAGCCCCACCGGG	0.687000													13	50					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100222560	100222560	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:100222560C>T	uc004axj.2	+	7	1181	c.956C>T	c.(955-957)TCC>TTC	p.S319F	TDRD7_uc011lux.1_Missense_Mutation_p.S245F	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	319	Lotus/OST-HTH 2.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				GTACCTCTATCCCCACTACCT	0.453000													7	40					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	100995792	100995792	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:100995792C>T	uc011lvb.1	-	4	867	c.687G>A	c.(685-687)CAG>CAA	p.Q229Q	TBC1D2_uc004ayq.2_Silent_p.Q229Q|TBC1D2_uc004ayr.2_Silent_p.Q11Q|TBC1D2_uc004ayo.3_Silent_p.Q229Q	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	229						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GGCCTGTTCCCTGGGCCTGCT	0.592000													40	178					0	0	1	0	0
COL15A1	1306	broad.mit.edu	37	9	101829329	101829329	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:101829329C>T	uc004azb.1	+	40	4023	c.3817C>T	c.(3817-3819)CTT>TTT	p.L1273F		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	1273	Nonhelical region 10 (NC10).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				GAGATACAGCCTTCCCATAGT	0.483000													12	83					0	0	1	0	0
TMEFF1	8577	broad.mit.edu	37	9	103204553	103204553	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:103204553C>T	uc004bay.1	+	1	366	c.333C>T	c.(331-333)ATC>ATT	p.I111I	C9orf30_uc004baw.2_Silent_p.I111I|C9orf30_uc004bax.2_RNA	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	Error:Variant_position_missing_in_Q8IYR6_after_alignment					multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				AGGAGAAGATCGCCAGCATGC	0.582000													13	47					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267137	107267137	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:107267137C>T	uc011lvm.1	+	1	594	c.594C>T	c.(592-594)ATC>ATT	p.I198I		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						TGCAGTTAATCATGCTGGTGA	0.438000													38	171					0	0	1	0	0
ALAD	210	broad.mit.edu	37	9	116153160	116153160	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:116153160G>A	uc011lxf.1	-	5	517	c.315C>T	c.(313-315)ATC>ATT	p.I105I	ALAD_uc011lxe.1_Silent_p.I88I|ALAD_uc004bhl.3_Silent_p.I134I	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	105					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	TCAACAGATGGATTGCCTCAA	0.587000													5	52					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116346682	116346682	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:116346682C>T	uc004bhq.2	+	21	3199	c.2990C>T	c.(2989-2991)TCC>TTC	p.S997F	RGS3_uc004bhs.2_Missense_Mutation_p.S887F|RGS3_uc004bht.2_Missense_Mutation_p.S716F|RGS3_uc010muy.2_Intron|RGS3_uc004bhv.2_Missense_Mutation_p.S318F|RGS3_uc010muz.1_Missense_Mutation_p.S336F|RGS3_uc004bhw.2_Intron|RGS3_uc011lxh.1_Missense_Mutation_p.S307F|RGS3_uc004bhx.2_Missense_Mutation_p.S318F|RGS3_uc004bhy.1_Missense_Mutation_p.S307F|RGS3_uc004bhz.2_Missense_Mutation_p.S339F	NM_144488	NP_652759	P49796	RGS3_HUMAN	regulator of G-protein signalling 3 isoform 6	997					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|lung(1)|skin(1)	3						CACCACCTTTCCCTCTTCTTC	0.612000													7	43					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117266558	117266558	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:117266558G>A	uc004biz.3	-	1	1173	c.524C>T	c.(523-525)TCT>TTT	p.S175F	DFNB31_uc004biy.3_5'Flank|DFNB31_uc004bja.3_Missense_Mutation_p.S175F|DFNB31_uc004bjb.2_Missense_Mutation_p.S175F	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	175	PDZ 1.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CTCAGCTAGAGAGCCTGGTTC	0.647000													26	130					0	0	1	0	0
TNFSF8	944	broad.mit.edu	37	9	117692581	117692581	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:117692581C>T	uc004bji.1	-	1	190	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	1	Cytoplasmic (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GCCCTGGGTCCATTCTTTATA	0.562000													16	66					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117810784	117810784	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:117810784G>A	uc004bjj.3	-	16	4969	c.4607C>T	c.(4606-4608)ACC>ATC	p.T1536I	TNC_uc010mvf.2_Intron	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	1536	Fibronectin type-III 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GTCGGAAATGGTTAGGTTTTC	0.493000													6	32					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118950481	118950481	+	Silent	SNP	C	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:118950481C>A	uc004bjn.2	+	2	1845	c.1464C>A	c.(1462-1464)CCC>CCA	p.P488P	PAPPA_uc011lxp.1_Silent_p.P281P|PAPPA_uc011lxq.1_Silent_p.P281P	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	488	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GCTTTGACCCCGACTCTCCAC	0.483000													8	47					0.000157383	0.000157956	1	1	0
PAPPA	5069	broad.mit.edu	37	9	118974082	118974082	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:118974082G>A	uc004bjn.2	+	4	2170	c.1789G>A	c.(1789-1791)GGA>AGA	p.G597R	PAPPA_uc011lxp.1_Intron|PAPPA_uc011lxq.1_Intron	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	597					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CTTCGAGACTGGAGACCTCTG	0.547000													36	163					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119033603	119033603	+	Splice_Site	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:119033603G>A	uc004bjn.2	+	9	3243	c.2862_splice	c.e9-1	p.K954_splice	PAPPA_uc011lxp.1_Splice_Site_p.K649_splice|PAPPA_uc011lxq.1_Splice_Site_p.K329_splice	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A						cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						CTGCTCTGCAGAGACCAAGGT	0.353000													25	98					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119065038	119065038	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:119065038G>A	uc004bjn.2	+	10	3337	c.2956G>A	c.(2956-2958)GAA>AAA	p.E986K	PAPPA_uc011lxp.1_Missense_Mutation_p.E681K|PAPPA_uc011lxq.1_Missense_Mutation_p.E361K	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	986					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						TTTTGCAGATGAACCCAGCCG	0.443000													12	22					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119188292	119188292	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:119188292G>A	uc004bjs.1	-	23	3959	c.3858C>T	c.(3856-3858)ATC>ATT	p.I1286I	ASTN2_uc004bjr.1_Silent_p.I1282I|ASTN2_uc004bjt.1_Silent_p.I1235I|ASTN2_uc004bjp.1_Silent_p.I379I|ASTN2_uc004bjq.1_Silent_p.I338I|ASTN2_uc011lxr.1_Silent_p.I338I|ASTN2_uc011lxs.1_Silent_p.I338I|ASTN2_uc011lxt.1_Silent_p.I338I|ASTN2_uc004bjo.1_Silent_p.I67I	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	1286	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGCGGCTCTGGATGTAGGCAC	0.577000													10	50					0	0	1	0	0
OR1J2	26740	broad.mit.edu	37	9	125273980	125273980	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:125273980C>T	uc004bmj.1	+	4	1755	c.900C>T	c.(898-900)GCC>GCT	p.A300A	OR1J2_uc011lyv.1_Silent_p.A300A	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						TGAAAGAGGCCCTTGGGAAAC	0.393000													11	45					0	0	1	0	0
OR1L4	254973	broad.mit.edu	37	9	125486428	125486428	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:125486428C>T	uc004bmu.1	+	1	160	c.160C>T	c.(160-162)CCC>TCC	p.P54S		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTACTCTGACCCCAGGCTCCA	0.473000													13	62					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126129486	126129486	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:126129486G>A	uc004bnx.1	+	5	882	c.790G>A	c.(790-792)GAG>AAG	p.E264K	CRB2_uc004bnw.1_Missense_Mutation_p.E264K	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	264	Extracellular (Potential).|EGF-like 6.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GGACGAGGACGAGTGTGCATC	0.682000													19	107					0	0	1	0	0
PPP6C	5537	broad.mit.edu	37	9	127912080	127912080	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:127912080G>A	uc004bpg.3	-	7	1011	c.790C>T	c.(790-792)CGT>TGT	p.R264C	PPP6C_uc010mwv.2_Missense_Mutation_p.R301C|PPP6C_uc010mww.2_Missense_Mutation_p.R242C|PPP6C_uc011lzr.1_Missense_Mutation_p.R117C	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	264					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						TTTCCACAACGATAGCAGTAA	0.403000													6	44					0	0	1	0	0
PPP6C	5537	broad.mit.edu	37	9	127933372	127933372	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:127933372G>A	uc004bpg.3	-	2	384	c.163C>T	c.(163-165)CAT>TAT	p.H55Y	PPP6C_uc010mwv.2_Missense_Mutation_p.H92Y|PPP6C_uc010mww.2_Missense_Mutation_p.H55Y|PPP6C_uc011lzr.1_5'UTR	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	55		Iron (By similarity).			G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						ACCTGTCCATGGATATCTCCA	0.378000													38	180					0	0	1	0	0
ZBTB43	23099	broad.mit.edu	37	9	129595113	129595113	+	Missense_Mutation	SNP	T	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:129595113T>A	uc004bql.2	+	3	598	c.325T>A	c.(325-327)TTC>ATC	p.F109I	ZBTB43_uc010mxf.2_Missense_Mutation_p.F109I	NM_014007	NP_054726	O43298	ZBT43_HUMAN	zinc finger and BTB domain containing 43	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGCGGCAAGCTTCCTCCAGAT	0.453000													16	63					0	0	1	0	0
LRSAM1	90678	broad.mit.edu	37	9	130251788	130251788	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:130251788C>T	uc004brb.1	+	19	1758	c.1413C>T	c.(1411-1413)ATC>ATT	p.I471I	LRSAM1_uc010mxk.1_Silent_p.I471I|LRSAM1_uc004brc.1_Silent_p.I471I|LRSAM1_uc004brd.1_Silent_p.I471I|LRSAM1_uc004bre.1_Silent_p.I51I	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	471					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						ATCGGCAGATCAGGAGCCAGG	0.637000													3	19					0	0	1	0	0
TTC16	158248	broad.mit.edu	37	9	130488642	130488642	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:130488642G>A	uc004brq.1	+	10	1451	c.1384G>A	c.(1384-1386)GAT>AAT	p.D462N	PTRH1_uc011mah.1_5'Flank|TTC16_uc011mai.1_Missense_Mutation_p.D449N|TTC16_uc004brr.1_Silent_p.R359R|TTC16_uc010mxn.1_Missense_Mutation_p.D58N	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	462							binding				0						GGCCCGCCAGGATGTGGCCAC	0.602000													15	61					0	0	1	0	0
ASS1	445	broad.mit.edu	37	9	133355802	133355802	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:133355802C>T	uc004bzm.2	+	12	1160	c.804C>T	c.(802-804)ATC>ATT	p.I268I	ASS1_uc004bzn.2_Silent_p.I268I|ASS1_uc010mza.2_Silent_p.I344I|ASS1_uc004bzo.2_Silent_p.I249I|ASS1_uc010mzb.2_Silent_p.I306I|ASS1_uc004bzp.2_Silent_p.I268I|ASS1_uc010mzc.2_Silent_p.I268I	NM_000050	NP_000041	P00966	ASSY_HUMAN	argininosuccinate synthetase 1	268					arginine biosynthetic process|urea cycle	cytosol	argininosuccinate synthase activity|ATP binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000514)	Adenosine triphosphate(DB00171)|L-Arginine(DB00125)|L-Aspartic Acid(DB00128)|L-Citrulline(DB00155)	GTATTGACATCGTGGAGAACC	0.612000													10	52					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135206523	135206524	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:135206523_135206524GG>AA	uc004cbk.2	-	9	1196_1197	c.1013_1014CC>TT	c.(1012-1014)ACC>ATT	p.T338I	SETX_uc004cbj.2_5'Flank|SETX_uc010mzt.2_5'Flank	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	338					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GTTCTAACTTGGTCCTTAAATA	0.342000													9	42					0	0	1	0	0
OBP2B	29989	broad.mit.edu	37	9	136081327	136081327	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:136081327C>T	uc004ccz.2	-	6	533	c.491G>A	c.(490-492)GGA>GAA	p.G164E	OBP2B_uc010nad.2_RNA|OBP2B_uc011mcy.1_Missense_Mutation_p.G96E	NM_014581	NP_055396	Q9NPH6	OBP2B_HUMAN	odorant binding protein 2B precursor	164					chemosensory behavior|sensory perception of smell	extracellular region	odorant binding|transporter activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.41e-06)|Epithelial(140;1.88e-05)		AACGCAGCTTCCTGCAGAGAC	0.617000													20	216					0	0	1	0	0
TMEM8C	389827	broad.mit.edu	37	9	136389850	136389850	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:136389850G>A	uc011mdk.1	-	1	117	c.117C>T	c.(115-117)TTC>TTT	p.F39F		NM_001080483	NP_001073952	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	39	Helical; (Potential).					integral to membrane					0						AGAACAGGGTGAAGAGGTAGA	0.632000													18	69					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137779021	137779021	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:137779021C>T	uc004cfg.1	+	8	712	c.702C>T	c.(700-702)TCC>TCT	p.S234S	FCN2_uc004cfh.1_Silent_p.S196S	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	234	Fibrinogen C-terminal.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		CAGGAGATTCCCTGACGTTCC	0.478000													21	120					0	0	1	0	0
KIAA0649	9858	broad.mit.edu	37	9	138377153	138377153	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:138377153C>T	uc004cfr.1	+	4	1346	c.797C>T	c.(796-798)TCC>TTC	p.S266F		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	266						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		CTCTTGAAATCCCACCAAGAG	0.512000													40	179					0	0	1	0	0
GLT6D1	360203	broad.mit.edu	37	9	138517989	138517989	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:138517989G>A	uc010nbd.1	-	4	437	c.183C>T	c.(181-183)TTC>TTT	p.F61F		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	61	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		CCCGCCTGTCGAAAGTCCCTT	0.507000													12	75					0	0	1	0	0
SOHLH1	402381	broad.mit.edu	37	9	138588462	138588462	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:138588462G>A	uc004cgl.2	-	5	718	c.657C>T	c.(655-657)TTC>TTT	p.F219F	SOHLH1_uc010nbe.2_Silent_p.F219F	NM_001012415	NP_001012415	Q5JUK2	SOLH1_HUMAN	spermatogenesis and oogenesis specific basic	219					cell differentiation|multicellular organismal development|oogenesis|regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(1)|central_nervous_system(1)	2		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.66e-07)|Epithelial(140;1.11e-06)|all cancers(34;6.45e-05)		ACTCACCTGAGAAAGGGGGCA	0.657000													5	31					0	0	1	0	0
KCNT1	57582	broad.mit.edu	37	9	138657527	138657527	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:138657527C>T	uc011mdq.1	+	13	1332	c.1258C>T	c.(1258-1260)CTG>TTG	p.L420L	KCNT1_uc011mdr.1_Silent_p.L247L|KCNT1_uc010nbf.2_Silent_p.L375L|KCNT1_uc004cgo.1_Silent_p.L169L	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	420						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		GCGCAGAGTCCTGCAGATCCC	0.637000													10	38					0	0	1	0	0
SNAPC4	6621	broad.mit.edu	37	9	139277730	139277730	+	Missense_Mutation	SNP	G	A	A	rs148400916		TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:139277730G>A	uc004chh.2	-	15	1900	c.1891C>T	c.(1891-1893)CCT>TCT	p.P631S		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	631					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GCCCTGGCAGGGACCTGCACC	0.716000													5	27					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139396258	139396258	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:139396258G>A	uc004chz.2	-	30	5580	c.5580C>T	c.(5578-5580)CCC>CCT	p.P1860P		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1860	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGGGCGGTGTGGGGGCCATGG	0.677000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			7	42					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139908410	139908410	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:139908410G>A	uc011mem.1	-	27	4466	c.4318C>T	c.(4318-4320)CAC>TAC	p.H1440Y	ABCA2_uc011mel.1_Missense_Mutation_p.H1441Y|ABCA2_uc004ckl.1_Missense_Mutation_p.H1371Y|ABCA2_uc004ckm.1_Missense_Mutation_p.H1471Y|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1440					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGCAGCCCGTGGAACTGGCGC	0.657000													11	41					0	0	1	0	0
C9orf139	401563	broad.mit.edu	37	9	139929490	139929490	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:139929490C>T	uc004ckp.1	+	3	2071	c.557C>T	c.(556-558)CCC>CTC	p.P186L	FUT7_uc004ckq.2_5'Flank	NM_207511	NP_997394	Q6ZV77	CI139_HUMAN	hypothetical protein LOC401563	186											0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		TCATCTCACCCCACCCAGGCC	0.587000													20	88					0	0	1	0	0
COBRA1	25920	broad.mit.edu	37	9	140157635	140157635	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:140157635G>A	uc004cmm.3	+	5	947	c.744G>A	c.(742-744)CTG>CTA	p.L248L		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	248					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		TGCACGACCTGGACGTGGGTG	0.587000													17	115					0	0	1	0	0
WDR85	92715	broad.mit.edu	37	9	140469207	140469207	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:140469207C>T	uc004cnk.1	-	4	622	c.464G>A	c.(463-465)GGA>GAA	p.G155E	WDR85_uc004cnl.1_5'UTR|WDR85_uc004cnm.1_5'UTR|WDR85_uc004cnn.1_Intron	NM_138778	NP_620133	Q9BTV6	WDR85_HUMAN	WD repeat domain 85	155					peptidyl-diphthamide biosynthetic process from peptidyl-histidine						0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.00029)|Epithelial(140;0.000509)		CCCTTACCTTCCAGTTTTCCC	0.567000													49	263					0	0	1	0	0
ARRDC1	92714	broad.mit.edu	37	9	140509073	140509073	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr9:140509073G>A	uc004cns.2	+	7	932	c.858G>A	c.(856-858)GTG>GTA	p.V286V	ARRDC1_uc004cnt.2_Silent_p.V161V|ARRDC1_uc004cnu.2_RNA|ARRDC1_uc004cnv.2_Silent_p.V266V|ARRDC1_uc004cnw.2_Silent_p.V161V|ARRDC1_uc004cnp.1_Silent_p.V286V|ARRDC1_uc004cnq.1_Silent_p.V268V|ARRDC1_uc011mfb.1_Silent_p.V161V|ARRDC1_uc004cnx.1_Silent_p.V161V|ARRDC1_uc004cny.2_RNA	NM_152285	NP_689498	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	286											0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		ATATTGCTGTGAACCATGCCC	0.672000													20	87					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3241150	3241150	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:3241150G>A	uc004crg.3	-	5	2733	c.2576C>T	c.(2575-2577)TCC>TTC	p.S859F		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	859						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCTGGCTGAGGAAATGGTACC	0.488000													17	32					0	0	1	0	0
TLR7	51284	broad.mit.edu	37	X	12904996	12904996	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:12904996C>T	uc004cvc.2	+	3	1508	c.1369C>T	c.(1369-1371)CCC>TCC	p.P457S		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	457	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	AAGTTATGAACCCCAGGTCCT	0.363000													10	31					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35971754	35971754	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:35971754G>A	uc004ddj.2	+	7	1151	c.1092G>A	c.(1090-1092)CAG>CAA	p.Q364Q	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	364										large_intestine(1)|lung(1)|ovary(1)	3						CATACAGACAGGACTATGCTC	0.323000													11	28					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35974281	35974281	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:35974281G>A	uc004ddj.2	+	8	1437	c.1378G>A	c.(1378-1380)GAA>AAA	p.E460K	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	460										large_intestine(1)|lung(1)|ovary(1)	3						AATTGATCCTGAAAAGGGCAA	0.373000													8	11					0	0	1	0	0
DDX3X	1654	broad.mit.edu	37	X	41202524	41202524	+	Missense_Mutation	SNP	A	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:41202524A>C	uc004dfe.2	+	7	1454	c.599A>C	c.(598-600)TAT>TCT	p.Y200S	DDX3X_uc010nhf.1_Missense_Mutation_p.Y184S|DDX3X_uc004dff.2_Missense_Mutation_p.Y200S|DDX3X_uc011mkq.1_Missense_Mutation_p.Y184S|DDX3X_uc011mkr.1_Missense_Mutation_p.Y200S|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	200	Q motif.|ATP.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						CTTACTCGTTATACTCGCCCA	0.398000										HNSCC(61;0.18)			24	26					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43652797	43652797	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:43652797G>A	uc004dfz.3	-	8	973	c.797C>T	c.(796-798)CCT>CTT	p.P266L	MAOB_uc011mkx.1_Missense_Mutation_p.P250L|MAOB_uc011mky.1_Missense_Mutation_p.P250L	NM_000898	NP_000889	P27338	AOFB_HUMAN	monoamine oxidase B	266	Cytoplasmic.				xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			ovary(1)|central_nervous_system(1)	2					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	GCCCAGAGTAGGAGGAATAGC	0.368000													29	34					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54275963	54275963	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:54275963C>T	uc004dtd.1	-	17	3257	c.2818G>A	c.(2818-2820)GAT>AAT	p.D940N	WNK3_uc004dtc.1_Missense_Mutation_p.D940N	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	940					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TCAACCACATCCTTGTGTTCT	0.398000													30	57					0	0	1	0	0
ZC4H2	55906	broad.mit.edu	37	X	64140111	64140111	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:64140111G>A	uc004dvu.2	-	3	336	c.248C>T	c.(247-249)TCT>TTT	p.S83F	ZC4H2_uc004dvv.2_Missense_Mutation_p.S60F|ZC4H2_uc011mov.1_Missense_Mutation_p.S60F|ZC4H2_uc011mow.1_Missense_Mutation_p.S83F|ZC4H2_uc004dvw.1_Missense_Mutation_p.S83F	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	83	Potential.						metal ion binding|protein binding			ovary(1)	1						GTCATTCTCAGATTGTTTGAT	0.413000													25	55					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962824	73962824	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:73962824C>T	uc004eby.2	-	3	2185	c.1568G>A	c.(1567-1569)TGG>TAG	p.W523*		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	523					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTTGGGACACCATTCATCATC	0.393000													6	9					0	0	1	0	0
P2RY10	27334	broad.mit.edu	37	X	78216114	78216114	+	Nonsense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:78216114C>T	uc004ede.2	+	4	466	c.97C>T	c.(97-99)CAA>TAA	p.Q33*	P2RY10_uc004edf.2_Nonsense_Mutation_p.Q33*	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	33	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						TGTGAAATTTCAATACTCCCT	0.428000													14	23					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83390150	83390150	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:83390150G>A	uc004eej.1	-	7	647	c.570C>T	c.(568-570)CAC>CAT	p.H190H	RPS6KA6_uc011mqt.1_Silent_p.H190H|RPS6KA6_uc011mqu.1_Silent_p.H87H|RPS6KA6_uc010nmo.1_RNA	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	190	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TTCCTAATTGGTGCAGATGAT	0.358000													7	8					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83400519	83400519	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:83400519C>T	uc004eej.1	-	6	545	c.468G>A	c.(466-468)AGG>AGA	p.R156R	RPS6KA6_uc011mqt.1_Silent_p.R156R|RPS6KA6_uc011mqu.1_Silent_p.R53R|RPS6KA6_uc010nmo.1_RNA	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	156	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						CATCTCCTCCCCTGAGAAAAT	0.303000													4	8					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	85950044	85950044	+	Missense_Mutation	SNP	G	A	A	rs149971925	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:85950044G>A	uc004eew.2	+	5	963	c.793G>A	c.(793-795)GAT>AAT	p.D265N	DACH2_uc004eex.2_Missense_Mutation_p.D252N|DACH2_uc010nmq.2_Missense_Mutation_p.D131N|DACH2_uc011mra.1_Missense_Mutation_p.D98N|DACH2_uc010nmr.2_Missense_Mutation_p.D46N	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						ATCCTCCTGGGATAAAGATAA	0.438000													6	15					0	0	1	0	0
NAP1L3	4675	broad.mit.edu	37	X	92926790	92926790	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:92926790C>T	uc004efq.2	-	1	1819	c.1514G>A	c.(1513-1515)AGA>AAA	p.R505K	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	505					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						GACTTATTTTCTGTATTTCTT	0.318000													9	7					0	0	1	0	0
LOC643486	643486	broad.mit.edu	37	X	95592478	95592478	+	RNA	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:95592478C>T	uc010nmx.2	-	1		c.424G>A				NR_003539				Homo sapiens cDNA FLJ42288 fis, clone TLIVE2006236.												0						TTTCCCAGATCCCTCTGATTT	0.388000													9	7					0	0	1	0	0
NXF5	55998	broad.mit.edu	37	X	101092587	101092587	+	Missense_Mutation	SNP	C	T	T	rs113591248	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:101092587C>T	uc011mrk.1	-	15	1319	c.959G>A	c.(958-960)CGA>CAA	p.R320Q	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	320	NTF2; truncated.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						GTCCACGTTTCGTGGACATTT	0.537000													23	47					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110653286	110653286	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:110653286C>T	uc004epd.2	-	2	756	c.584G>A	c.(583-585)GGA>GAA	p.G195E	DCX_uc011msv.1_Missense_Mutation_p.G195E|DCX_uc004epe.2_Missense_Mutation_p.G114E|DCX_uc004epf.2_Missense_Mutation_p.G114E|DCX_uc004epg.2_Missense_Mutation_p.G114E	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	195	Doublecortin 1.				axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						ATCCATGCTTCCGATCTTCCT	0.498000													25	44					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111155755	111155756	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:111155755_111155756GG>AA	uc004epl.1	-	3	1582_1583	c.663_664CC>TT	c.(661-666)TTCCGT>TTTTGT	p.R222C	TRPC5_uc004epm.1_Missense_Mutation_p.R222C	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	222	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						CAGCCCAGACGGAAGGCAGTTA	0.554000													39	122					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118220960	118220960	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:118220960G>A	uc004era.3	-	11	4233	c.4233C>T	c.(4231-4233)TTC>TTT	p.F1411F		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1411										ovary(4)|skin(1)	5						AACCTTGGCTGAATTTCTTGG	0.463000													21	40					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130417074	130417074	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:130417074C>T	uc004ewd.2	-	6	1070	c.832G>A	c.(832-834)GAG>AAG	p.E278K	IGSF1_uc004ewe.3_Missense_Mutation_p.E267K|IGSF1_uc004ewf.2_Missense_Mutation_p.E258K	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	278	Ig-like C2-type 3.|Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						AAATTTGCCTCATTTTTTATT	0.398000													21	21					0	0	1	0	0
OR13H1	347468	broad.mit.edu	37	X	130678815	130678815	+	Silent	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:130678815C>T	uc011muw.1	+	1	768	c.768C>T	c.(766-768)TCC>TCT	p.S256S	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					CAGCCATCTCCATGTATATGA	0.473000													25	47					0	0	1	0	0
FAM127B	26071	broad.mit.edu	37	X	134185923	134185923	+	Silent	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:134185923G>A	uc004eyf.2	-	1	299	c.216C>T	c.(214-216)CTC>CTT	p.L72L	FAM127B_uc004eyg.3_Intron	NM_001078172	NP_001071640	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	72											0	Acute lymphoblastic leukemia(192;0.000127)					CTGGCCCCGTGAGGCGGGTGA	0.602000													20	46					0	0	1	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135827495	135827495	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:135827495C>T	uc004fab.2	-	4	808	c.346G>A	c.(346-348)GAA>AAA	p.E116K	ARHGEF6_uc011mwd.1_5'UTR|ARHGEF6_uc011mwe.1_5'UTR	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	116					apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					CATGGTCTTTCTGATAGCTGA	0.428000													28	67					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138669927	138669927	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:138669927C>T	uc004fau.2	-	22	2764	c.2470G>A	c.(2470-2472)GAT>AAT	p.D824N	MCF2_uc004fav.2_Missense_Mutation_p.D840N|MCF2_uc011mwl.1_Missense_Mutation_p.D801N|MCF2_uc010nsh.1_Missense_Mutation_p.D824N|MCF2_uc011mwm.1_Missense_Mutation_p.D785N|MCF2_uc011mwn.1_Missense_Mutation_p.D969N|MCF2_uc004faw.2_Missense_Mutation_p.D884N|MCF2_uc011mwo.1_Missense_Mutation_p.D900N	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	824					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GTTAATTGATCCTGTTGCTTT	0.328000													13	20					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995261	140995261	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:140995261C>T	uc004fbt.2	+	4	2357	c.2071C>T	c.(2071-2073)CCT>TCT	p.P691S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	691							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCCTGTCTCCTCTCCAAAT	0.567000										HNSCC(15;0.026)			21	29					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795241	142795241	+	Missense_Mutation	SNP	C	T	T			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:142795241C>T	uc004fbz.2	-	2	1191	c.437G>A	c.(436-438)GGA>GAA	p.G146E		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	146										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGAAGATCCTTCAGATGA	0.527000													73	131					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967602	142967602	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:142967602G>A	uc004fca.2	+	1	430	c.400G>A	c.(400-402)GAA>AAA	p.E134K		NM_001012989	NP_001013007	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	134							acid-amino acid ligase activity				0	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGACCAACGAAGCCCAAGC	0.438000													31	71					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151358362	151358362	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:151358362G>A	uc010ntk.1	-	9	1223	c.983C>T	c.(982-984)TCC>TTC	p.S328F		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	328					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTAGGTAAGGAATTTCTGGC	0.458000													8	19					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151424446	151424446	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrX:151424446G>A	uc010ntk.1	-	5	595	c.355C>T	c.(355-357)CGG>TGG	p.R119W		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	119	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CATGTCTGCCGAAAAAATACA	0.423000													11	15					0	0	1	0	0
RPS4Y2	140032	broad.mit.edu	37	Y	22930724	22930724	+	Missense_Mutation	SNP	G	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chrY:22930724G>A	uc011nbb.1	+	5	490	c.394G>A	c.(394-396)GGG>AGG	p.G132R		NM_001039567	NP_001034656	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	132					translation	ribosome	rRNA binding|structural constituent of ribosome				0						GATTACTGTGGGGACAAAGGG	0.443000													21	34					0	0	1	0	0
MMEL1	79258	broad.mit.edu	37	1	2560819	2560821	+	In_Frame_Del	DEL	CAG	-	-			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr1:2560819_2560821delCAG	uc001ajy.2	-	2	317_319	c.103_105delCTG	c.(103-105)CTGdel	p.L35del	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	35	Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAGCGGTCACcagcagcagcagc	0.665													4	6	---	---	---	---					
C11orf9	745	broad.mit.edu	37	11	61547737	61547739	+	In_Frame_Del	DEL	GAG	-	-			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr11:61547737_61547739delGAG	uc001nsc.1	+	18	2476_2478	c.2380_2382delGAG	c.(2380-2382)GAGdel	p.E795del	C11orf9_uc001nse.1_In_Frame_Del_p.E786del|C11orf9_uc010rll.1_In_Frame_Del_p.E186del	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	795					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CCTGCGCACAGAGGAGGACCTGG	0.611													7	75	---	---	---	---					
ITPR2	3709	broad.mit.edu	37	12	26647141	26647142	+	Frame_Shift_Ins	INS	-	A	A			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr12:26647141_26647142insA	uc001rhg.2	-	39	5731_5732	c.5314_5315insT	c.(5314-5316)TCAfs	p.S1772fs	ITPR2_uc009zjg.1_5'UTR	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1772	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AATGCCTTCTGAAAAAATTCTG	0.381													9	75	---	---	---	---					
CDH1	999	broad.mit.edu	37	16	68771348	68771350	+	In_Frame_Del	DEL	GCT	-	-			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr16:68771348_68771350delGCT	uc002ewg.1	+	1	154_156	c.30_32delGCT	c.(28-33)GCGCTG>GCG	p.L15del	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_In_Frame_Del_p.L15del	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	15					adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(1)|p.L8fs*41(1)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GCCTCTCGGCGCTGCTGCTGCTG	0.527			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				2	4	---	---	---	---					
RPL38	6169	broad.mit.edu	37	17	72205441	72205442	+	Frame_Shift_Ins	INS	-	C	C			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr17:72205441_72205442insC	uc002jjz.2	+	4	308_309	c.180_181insC	c.(178-183)CTGCCCfs	p.L60fs	RPL38_uc002jka.2_Frame_Shift_Ins_p.L60fs	NM_000999	NP_000990	P63173	RL38_HUMAN	ribosomal protein L38	60_61					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0						AGCAGTCCCTGCCCCCCGGTGA	0.490													19	146	---	---	---	---					
DOCK6	57572	broad.mit.edu	37	19	11356550	11356551	+	Frame_Shift_Del	DEL	CG	-	-	rs141338642	by1000genomes	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:11356550_11356551delCG	uc002mqs.3	-	8	851_852	c.810_811delCG	c.(808-813)TTCGAGfs	p.F270fs		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	270_271					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						ATTTCAATCTCGAACCTACAAG	0.530													2	4	---	---	---	---					
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	-	-	rs141441894	byFrequency	TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr19:43969653_43969655delAGC	uc002owl.1	-	1	177_179	c.69_71delGCT	c.(67-72)CTGCTT>CTT	p.23_24LL>L	LYPD3_uc002owm.2_In_Frame_Del_p.23_24LL>L	NM_014400	NP_055215	O95274	LYPD3_HUMAN	GPI-anchored metastasis-associated protein	23_24						anchored to plasma membrane				pancreas(1)	1		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675													7	243	---	---	---	---					
PRDM15	63977	broad.mit.edu	37	21	43221415	43221417	+	In_Frame_Del	DEL	CTG	-	-			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr21:43221415_43221417delCTG	uc002yzq.1	-	31	4618_4620	c.4507_4509delCAG	c.(4507-4509)CAGdel	p.Q1503del	PRDM15_uc002yzo.2_In_Frame_Del_p.Q1174del|PRDM15_uc002yzp.2_In_Frame_Del_p.Q1194del|PRDM15_uc002yzr.1_In_Frame_Del_p.Q1194del	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1503	Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGCTGTACATCTGCTGCTGCTGC	0.611													9	156	---	---	---	---					
VPS13B	157680	broad.mit.edu	37	8	100133469	100133469	+	Frame_Shift_Del	DEL	T	-	-			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:100133469delT	uc003yiv.2	+	8	1113	c.1002delT	c.(1000-1002)TATfs	p.Y334fs	VPS13B_uc003yiw.2_Frame_Shift_Del_p.Y334fs|VPS13B_uc003yit.2_Frame_Shift_Del_p.Y334fs|VPS13B_uc003yiu.1_Frame_Shift_Del_p.Y334fs|VPS13B_uc003yis.2_Frame_Shift_Del_p.Y334fs|VPS13B_uc011lgy.1_Frame_Shift_Del_p.Y210fs	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	334					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAGAGTTATATTCACAGCAAG	0.403													8	38	---	---	---	---					
NDRG1	10397	broad.mit.edu	37	8	134296497	134296498	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-DA-A3F8-06A-11D-A20D-08	TCGA-DA-A3F8-10A-01D-A20D-08									Somatic	Phase_I	Capture				Illumina GAIIx	978ae91e-6ebe-4efa-97ff-cfad511ae7b3	d7b2aeed-1a42-4335-a545-0d284fc5e463	g.chr8:134296497_134296498delCT	uc003yuh.2	-	2	643_644	c.57_58delAG	c.(55-60)AAAGGGfs	p.K19fs	NDRG1_uc003yug.2_Frame_Shift_Del_p.K19fs|NDRG1_uc010mee.2_5'UTR|NDRG1_uc010mef.2_Intron|NDRG1_uc011ljh.1_5'UTR|NDRG1_uc011lji.1_Intron	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	19_20					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CTCACCTCCCCTTTCTCCACCA	0.376													25	69	---	---	---	---					
