Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACTRT2	140625	broad.mit.edu	37	1	2938344	2938344	+	Silent	SNP	C	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:2938344C>A	uc001ajz.2	+	1	299	c.94C>A	c.(94-96)CGG>AGG	p.R32R		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	32						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GTTTGGACCCCGGCACATGGT	0.577000													4	29					2.56e-06	1.61305e-05	0.000248	1	0
RSPO1	284654	broad.mit.edu	37	1	38082336	38082336	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:38082336C>T	uc001cbl.1	-	5	894	c.106G>A	c.(106-108)GGG>AGG	p.G36R	RSPO1_uc001cbm.1_Missense_Mutation_p.G36R|RSPO1_uc009vvf.1_Missense_Mutation_p.G9R|RSPO1_uc009vvg.1_Missense_Mutation_p.G36R	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	36	FU 1.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCCTGGCTCCCCTCGGCACTG	0.557000													22	29					0	0	0.001882	0	0
C8B	732	broad.mit.edu	37	1	57425769	57425769	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:57425769A>G	uc001cyp.2	-	2	240	c.173T>C	c.(172-174)GTT>GCT	p.V58A	C8B_uc010oon.1_5'UTR|C8B_uc010ooo.1_Missense_Mutation_p.V6A	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	58					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						CATCAGGGTAACATCCACACT	0.488000													31	21					0	0	0.008361	0	0
TACSTD2	4070	broad.mit.edu	37	1	59042177	59042177	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:59042177C>T	uc001cyz.3	-	1	990	c.652G>A	c.(652-654)GAT>AAT	p.D218N		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	218	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					TCGCCGATATCCACGTCACCG	0.652000													3	9					0	0	0.000602	0	0
FCRLB	127943	broad.mit.edu	37	1	161693304	161693304	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:161693304T>G	uc001gbh.2	+	5	434	c.200T>G	c.(199-201)CTT>CGT	p.L67R	FCRLB_uc009wus.2_Missense_Mutation_p.L67R|FCRLB_uc001gbj.2_Missense_Mutation_p.L67R|FCRLB_uc001gbk.2_Missense_Mutation_p.L67R|FCRLB_uc001gbl.2_Missense_Mutation_p.L60R|FCRLB_uc001gbm.2_Missense_Mutation_p.L60R|FCRLB_uc001gbi.2_Missense_Mutation_p.L67R|FCRLB_uc001gbn.3_5'Flank	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	67	Ig-like C2-type 1.					endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			GGCCACCTACTTCTGCCCTCT	0.557000													8	63					0	0	0.003080	0	0
PTPRC	5788	broad.mit.edu	37	1	198685933	198685933	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:198685933A>T	uc001gur.1	+	13	1588	c.1408A>T	c.(1408-1410)AGT>TGT	p.S470C	PTPRC_uc001gus.1_Missense_Mutation_p.S422C|PTPRC_uc001gut.1_Missense_Mutation_p.S309C|PTPRC_uc009wzf.1_Missense_Mutation_p.S358C|PTPRC_uc010ppg.1_Missense_Mutation_p.S406C	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	470	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						ACGTAATGGAAGTGCTGCAAT	0.303000													21	27					0	0	0.001523	0	0
DDX59	83479	broad.mit.edu	37	1	200635682	200635682	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:200635682G>A	uc009wzk.2	-	2	430	c.187C>T	c.(187-189)CCC>TCC	p.P63S	DDX59_uc010ppl.1_Missense_Mutation_p.P63S	NM_001031725	NP_001026895	Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	63						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CCTGGGCTGGGGAAAGGGCAT	0.517000													14	52					0	0	0.002450	0	0
CR2	1380	broad.mit.edu	37	1	207646442	207646442	+	Silent	SNP	T	C	C			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr1:207646442T>C	uc001hfw.2	+	10	1990	c.1896T>C	c.(1894-1896)AGT>AGC	p.S632S	CR2_uc001hfv.2_Silent_p.S632S|CR2_uc009xch.2_Silent_p.S632S|CR2_uc009xci.1_Silent_p.S117S	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	632	Sushi 10.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						AGTGTTATAGTGGATTTACTT	0.408000													14	45					0	0	0.003163	0	0
CAMK1D	57118	broad.mit.edu	37	10	12858327	12858327	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr10:12858327G>A	uc001ilo.2	+	8	1068	c.833G>A	c.(832-834)TGG>TAG	p.W278*	CAMK1D_uc001iln.2_Nonsense_Mutation_p.W278*	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	278	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		CGGCACCCATGGTAAGGAAAT	0.502000													71	47					0	0	0.003610	0	0
SVIL	6840	broad.mit.edu	37	10	29812856	29812856	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr10:29812856G>A	uc001iut.1	-	15	3440	c.2687C>T	c.(2686-2688)ACA>ATA	p.T896I	SVIL_uc010qdw.1_5'Flank|SVIL_uc001iuu.1_Missense_Mutation_p.T470I	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	896					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AGGTGGCTTTGTGCGAAGATC	0.463000													33	21					0	0	0.002836	0	0
BMS1	9790	broad.mit.edu	37	10	43281075	43281075	+	Missense_Mutation	SNP	C	G	G	rs139468293		TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr10:43281075C>G	uc001jaj.2	+	3	680	c.322C>G	c.(322-324)CGG>GGG	p.R108G		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	108					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAACTTTACCCGGCAGAAGTT	0.517000													3	97					0	0	0.000248	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62645910	62645910	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr10:62645910G>A	uc001jli.2	-	8	1973	c.1535C>T	c.(1534-1536)GCC>GTC	p.A512V	RHOBTB1_uc001jlh.2_Missense_Mutation_p.A512V|RHOBTB1_uc001jlj.2_Missense_Mutation_p.A512V|RHOBTB1_uc001jlk.2_Missense_Mutation_p.A512V|RHOBTB1_uc009xpe.1_Missense_Mutation_p.A450V|RHOBTB1_uc001jll.2_Missense_Mutation_p.A262V	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	512	BTB 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					CCCGAACATGGCTGCCATCCA	0.488000													10	63					0	0	0.008291	0	0
ANKRD22	118932	broad.mit.edu	37	10	90582732	90582732	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr10:90582732G>A	uc001kfj.3	-	6	910	c.542C>T	c.(541-543)TCC>TTC	p.S181F		NM_144590	NP_653191	Q5VYY1	ANR22_HUMAN	ankyrin repeat domain 22	181											0		Colorectal(252;0.0163)		Colorectal(12;6.29e-05)|COAD - Colon adenocarcinoma(12;7.69e-05)		TTCAATCTGGGAAAATTTTAA	0.393000													16	65					0	0	0.004990	0	0
C10orf137	26098	broad.mit.edu	37	10	127412503	127412503	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr10:127412503C>T	uc001liq.1	+	4	801	c.508C>T	c.(508-510)CAG>TAG	p.Q170*	C10orf137_uc001lin.2_Nonsense_Mutation_p.Q170*|C10orf137_uc001lio.1_Nonsense_Mutation_p.Q170*|C10orf137_uc001lip.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				GAGATCGTCTCAGGTAATGCT	0.398000													22	15					0	0	0.002299	0	0
MUC5B	727897	broad.mit.edu	37	11	1265993	1265993	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:1265993G>T	uc009ycr.1	+	48	9923	c.9797G>T	c.(9796-9798)CGC>CTC	p.R3266L	MUC5B_uc001ltb.2_Missense_Mutation_p.R2631L	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2628	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			Missing (in Ref. 6; AAB61398).|RTL -> LTP (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGGACGGCACGCACGCTTCCA	0.642000													7	90					1.08611e-07	6.91063e-07	0.000978	1	0
MUC5B	727897	broad.mit.edu	37	11	1265997	1265997	+	Silent	SNP	G	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:1265997G>T	uc009ycr.1	+	48	9927	c.9801G>T	c.(9799-9801)ACG>ACT	p.T3267T	MUC5B_uc001ltb.2_Silent_p.T2632T	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2629	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.			Missing (in Ref. 6; AAB61398).|RTL -> LTP (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CGGCACGCACGCTTCCAGTGT	0.637000													6	88					3.07112e-06	1.9165e-05	0.000978	1	0
OR52M1	119772	broad.mit.edu	37	11	4566516	4566516	+	Silent	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:4566516C>T	uc010qyf.1	+	1	96	c.96C>T	c.(94-96)CCC>CCT	p.P32P		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTCCATCCCCTTTGGCTCCA	0.542000													9	55					0	0	0.004482	0	0
DNHD1	144132	broad.mit.edu	37	11	6592281	6592281	+	Silent	SNP	A	C	C			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:6592281A>C	uc001mdw.3	+	42	14103	c.13539A>C	c.(13537-13539)GCA>GCC	p.A4513A	DNHD1_uc001mea.3_Silent_p.A782A|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Silent_p.A781A|DNHD1_uc010rao.1_Silent_p.A771A|DNHD1_uc009yfg.2_Silent_p.A138A	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4513					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TGAAGGGCGCACCCCCGTGCC	0.677000													6	25					0	0	0.006214	0	0
GLYATL2	219970	broad.mit.edu	37	11	58604592	58604592	+	Silent	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:58604592C>T	uc001nnd.3	-	5	503	c.372G>A	c.(370-372)CAG>CAA	p.Q124Q	GLYATL2_uc009ymq.2_Silent_p.Q124Q	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	124						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TGTAATCTACCTGCACTGATT	0.393000													21	25					0	0	0.008871	0	0
MS4A1	931	broad.mit.edu	37	11	60233627	60233627	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:60233627C>A	uc001npp.2	+	6	986	c.570C>A	c.(568-570)TTC>TTA	p.F190L	MS4A1_uc001npq.2_Missense_Mutation_p.F190L|MS4A1_uc009yna.2_Missense_Mutation_p.F190L|MS4A1_uc009ymz.2_Missense_Mutation_p.F190L|MS4A1_uc010rlc.1_Intron	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	190	Helical; (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	AATCTCTGTTCTTGGTAAGTG	0.333000													9	45					2.74318e-10	1.78032e-09	0.006214	1	0
STX5	6811	broad.mit.edu	37	11	62592938	62592938	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:62592938C>T	uc001nvh.2	-	6	651	c.497G>A	c.(496-498)CGG>CAG	p.R166Q	STX5_uc010rmi.1_Missense_Mutation_p.R70Q|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Missense_Mutation_p.R112Q|STX5_uc010rmj.1_Missense_Mutation_p.R166Q|STX5_uc001nvj.2_5'UTR	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	166	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						CTGCAGGTGCCGGCCACTCTG	0.532000													6	78					0	0	0.003080	0	0
KIAA1377	57562	broad.mit.edu	37	11	101833837	101833837	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:101833837G>A	uc001pgm.2	+	6	2341	c.2071G>A	c.(2071-2073)GAG>AAG	p.E691K	KIAA1377_uc001pgn.2_Missense_Mutation_p.E647K|KIAA1377_uc010run.1_Missense_Mutation_p.E492K|KIAA1377_uc009yxa.1_Missense_Mutation_p.E492K	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	691							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		GAAGTCCAGGGAGGATTCTAT	0.383000													35	53					0	0	0.002222	0	0
HTR3B	9177	broad.mit.edu	37	11	113802112	113802112	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:113802112G>A	uc001pok.2	+	3	287	c.220G>A	c.(220-222)GAG>AAG	p.E74K	HTR3B_uc001pol.2_Missense_Mutation_p.E63K	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	74	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		GCAGGATGCAGAGAATCAAAT	0.328000													5	14					0	0	0.003080	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120300219	120300219	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:120300219G>A	uc001pxl.1	+	9	663	c.656G>A	c.(655-657)CGG>CAG	p.R219Q	ARHGEF12_uc009zat.2_Missense_Mutation_p.R200Q|ARHGEF12_uc010rzn.1_Missense_Mutation_p.R116Q|ARHGEF12_uc009zau.1_Missense_Mutation_p.R116Q	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	219	Potential.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		GAACAGGAACGGCTACAGGTA	0.358000			T	MLL	AML								21	28					0	0	0.002299	0	0
CD4	920	broad.mit.edu	37	12	6909590	6909590	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr12:6909590C>T	uc001qqv.1	+	3	412	c.167C>T	c.(166-168)TCC>TTC	p.S56F	CD4_uc009zez.1_Intron|CD4_uc009zfa.1_Intron|CD4_uc009zfb.1_Intron|CD4_uc010sfj.1_Intron|CD4_uc009zfc.1_Intron|CD4_uc010sfk.1_Intron|CD4_uc010sfl.1_Intron	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	56	Extracellular (Potential).|Ig-like V-type.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				TGGAAAAACTCCAACCAGATA	0.473000													8	20					0	0	0.006214	0	0
DAZAP2	9802	broad.mit.edu	37	12	51636137	51636137	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr12:51636137C>G	uc010snd.1	+	4	509	c.325C>G	c.(325-327)CAA>GAA	p.Q109E	DAZAP2_uc001ryb.2_Silent_p.P112P|DAZAP2_uc010snc.1_Silent_p.P52P|DAZAP2_uc010sne.1_Silent_p.P102P|DAZAP2_uc010snf.1_Intron	NM_001136266	NP_001129738	Q15038	DAZP2_HUMAN	DAZ associated protein 2 isoform c	Error:Variant_position_missing_in_Q15038_after_alignment							WW domain binding				0						GATGCCCTCCCAATGCTGCTC	0.542000													4	249					0	0	0.000248	0	0
TMTC2	160335	broad.mit.edu	37	12	83289710	83289710	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr12:83289710G>A	uc001szt.2	+	3	1200	c.768G>A	c.(766-768)TCG>TCA	p.S256S	TMTC2_uc001szr.1_Silent_p.S256S|TMTC2_uc001szs.1_Silent_p.S256S|TMTC2_uc010suk.1_Silent_p.S11S	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	256						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TTTCCAACTCGGACAACCCCG	0.507000													41	55					0	0	0.002522	0	0
PITPNM2	57605	broad.mit.edu	37	12	123489978	123489978	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr12:123489978G>T	uc001uej.1	-	6	900	c.761C>A	c.(760-762)TCC>TAC	p.S254Y	PITPNM2_uc001uek.1_Missense_Mutation_p.S254Y|PITPNM2_uc009zxu.1_Missense_Mutation_p.S254Y	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	254					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CATCTTACGGGAAAGCATGAG	0.637000													33	64					1.22384e-17	8.02292e-17	0.002836	1	0
EDDM3A	10876	broad.mit.edu	37	14	21215878	21215878	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr14:21215878G>A	uc001vyb.2	+	2	206	c.139G>A	c.(139-141)GAG>AAG	p.E47K	EDDM3A_uc001vyc.2_Missense_Mutation_p.E47K	NM_006683	NP_006674	Q14507	EP3A_HUMAN	human epididymis-specific 3 alpha precursor	47					sperm displacement	extracellular space					0						AGAATTCAAAGAGTACAAATG	0.383000													16	24					0	0	0.004007	0	0
L2HGDH	79944	broad.mit.edu	37	14	50713919	50713919	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr14:50713919C>T	uc001wxu.2	-	10	1328	c.1249G>A	c.(1249-1251)GAA>AAA	p.E417K	L2HGDH_uc010tqn.1_Intron|L2HGDH_uc010tqo.1_Missense_Mutation_p.E417K	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	417					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					ACAAAATCTTCTACCAGATTT	0.453000													9	20					0	0	0.006214	0	0
C15orf23	90417	broad.mit.edu	37	15	40675132	40675132	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr15:40675132G>A	uc001zll.2	+	1	211	c.96G>A	c.(94-96)CGG>CGA	p.R32R	C15orf23_uc010ucp.1_Silent_p.R32R|C15orf23_uc001zlo.2_Silent_p.R32R|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	32						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		CTAGCTACCGGAAGTTTCTAT	0.577000													31	50					0	0	0.002836	0	0
FRMD5	84978	broad.mit.edu	37	15	44211676	44211676	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr15:44211676G>A	uc001ztl.2	-	4	487	c.310C>T	c.(310-312)CTG>TTG	p.L104L	FRMD5_uc001ztk.1_Silent_p.L15L|FRMD5_uc001ztm.2_5'UTR|FRMD5_uc001ztn.2_5'UTR	NM_032892	NP_116281	Q7Z6J6	FRMD5_HUMAN	FERM domain containing 5 isoform 2	104	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(109;2.29e-15)|all_epithelial(112;9.98e-13)|Lung NSC(122;4.89e-08)|all_lung(180;5.08e-07)|Melanoma(134;0.0275)		all cancers(107;8.63e-20)|GBM - Glioblastoma multiforme(94;3.63e-06)		TCTTCTTTCAGAGCAGCAGGG	0.517000													103	85					0	0	0.003610	0	0
KIAA1370	56204	broad.mit.edu	37	15	52901077	52901077	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr15:52901077G>A	uc002acg.3	-	6	2187	c.2034C>T	c.(2032-2034)TCC>TCT	p.S678S	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Silent_p.S590S|KIAA1370_uc010ugf.1_Silent_p.S685S	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	678											0				all cancers(107;0.0803)		CATTTTTTTTGGAATCATCAG	0.284000													18	33					0	0	0.004990	0	0
ALPK3	57538	broad.mit.edu	37	15	85400485	85400485	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr15:85400485C>T	uc002ble.2	+	6	3289	c.3122C>T	c.(3121-3123)CCC>CTC	p.P1041L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1041					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TTCCAGTGCCCCAAGGAGGAG	0.642000													14	11					0	0	0.001855	0	0
C15orf42	90381	broad.mit.edu	37	15	90170259	90170260	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr15:90170259_90170260CC>AA	uc002boe.2	+	22	5675_5676	c.5675_5676CC>AA	c.(5674-5676)CCC>CAA	p.P1892Q	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1892					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			AGGAGGCGCCCCATCAGCAGAA	0.500000													7	138					0	0	0.004672	0	0
ZNF213	7760	broad.mit.edu	37	16	3188500	3188500	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr16:3188500C>T	uc010uws.1	+	3	928	c.481C>T	c.(481-483)CGG>TGG	p.R161W	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_3'UTR|ZNF213_uc010bth.2_Missense_Mutation_p.R161W|ZNF213_uc010uwt.1_Missense_Mutation_p.R161W	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	161					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGTGGGGGCACGGAGGCGGCC	0.672000													26	21					0	0	0.003954	0	0
PRSS8	5652	broad.mit.edu	37	16	31144273	31144273	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr16:31144273C>T	uc002ebc.3	-	4	600	c.268G>A	c.(268-270)GAG>AAG	p.E90K	PRSS8_uc010vfe.1_Intron	NM_002773	NP_002764	Q16651	PRSS8_HUMAN	prostasin preproprotein	90	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity				0						TTGTGGTGCTCGCTGCAGGCA	0.607000													50	35					0	0	0.003610	0	0
PHKB	5257	broad.mit.edu	37	16	47722962	47722962	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr16:47722962C>T	uc002eev.3	+	27	2693	c.2641C>T	c.(2641-2643)CAT>TAT	p.H881Y	PHKB_uc002eeu.3_Missense_Mutation_p.H874Y|PHKB_uc002eew.3_Missense_Mutation_p.H122Y	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	881					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GTGGATCATCCATGCCATGGA	0.448000													16	29					0	0	0.006122	0	0
MON1B	22879	broad.mit.edu	37	16	77225452	77225452	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr16:77225452C>T	uc002fez.2	+	2	400	c.70C>T	c.(70-72)CCC>TCC	p.P24S	MON1B_uc010vnf.1_Missense_Mutation_p.P24S|MON1B_uc010vng.1_Intron|MON1B_uc002ffa.2_5'Flank	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	24							protein binding				0						CACGCAGTTCCCCAGTGAGGA	0.537000													3	9					0	0	0.004672	0	0
OR1D2	4991	broad.mit.edu	37	17	2995776	2995776	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr17:2995776C>T	uc010vrb.1	-	1	515	c.515G>A	c.(514-516)CGA>CAA	p.R172Q		NM_002548	NP_002539	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D,	172	Extracellular (Potential).				cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GTGGATTTTTCGTGACCCACA	0.468000													10	26					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	17	39296167	39296167	+	RNA	SNP	A	G	G			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr17:39296167A>G	uc010cxk.1	-	1		c.537T>C								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		GGCAGGTGGAAATGACACAGG	0.478000													3	5					0	0	0.004672	0	0
C17orf47	284083	broad.mit.edu	37	17	56620976	56620976	+	Missense_Mutation	SNP	C	T	T	rs140186503		TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr17:56620976C>T	uc002iwq.1	-	1	708	c.572G>A	c.(571-573)CGT>CAT	p.R191H	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	191										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAAAATCCTACGGGGAACTCT	0.448000													20	60					0	0	0.008871	0	0
SLC38A10	124565	broad.mit.edu	37	17	79226242	79226242	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr17:79226242G>A	uc002jzz.1	-	13	2073	c.1698C>T	c.(1696-1698)GCC>GCT	p.A566A	SLC38A10_uc002jzy.1_Silent_p.A484A|SLC38A10_uc002kab.2_Silent_p.A566A	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	566					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCTCCTCCAAGGCCTGGGCCT	0.627000													25	35					0	0	0.008361	0	0
NOL4	8715	broad.mit.edu	37	18	31599485	31599485	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr18:31599485C>T	uc010dmi.2	-	6	1082	c.853G>A	c.(853-855)GAG>AAG	p.E285K	NOL4_uc010xbs.1_5'UTR|NOL4_uc002kxr.3_Missense_Mutation_p.E121K|NOL4_uc010xbt.1_Missense_Mutation_p.E211K|NOL4_uc010dmh.2_Missense_Mutation_p.E211K|NOL4_uc010xbu.1_Missense_Mutation_p.E285K|NOL4_uc002kxt.3_Missense_Mutation_p.E285K|NOL4_uc010xbv.1_Missense_Mutation_p.E34K|NOL4_uc010xbw.1_Missense_Mutation_p.E171K	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	285						nucleolus	RNA binding			ovary(3)	3						TCTCCCATCTCCCTGCTGTGT	0.507000													5	36					0	0	0.000602	0	0
ZNF532	55205	broad.mit.edu	37	18	56585630	56585630	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr18:56585630T>G	uc002lho.2	+	4	658	c.111T>G	c.(109-111)CAT>CAG	p.H37Q	ZNF532_uc002lhp.2_Missense_Mutation_p.H35Q|ZNF532_uc010xeg.1_Missense_Mutation_p.H35Q|ZNF532_uc002lhr.2_Missense_Mutation_p.H35Q|ZNF532_uc002lhs.2_Missense_Mutation_p.H35Q	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						ACGATGACCATGAAAGCCACA	0.493000													8	29					0	0	0.003080	0	0
SERPINB4	6318	broad.mit.edu	37	18	61328390	61328390	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr18:61328390T>A	uc002ljg.2	-	1	87	c.61A>T	c.(61-63)AAA>TAA	p.K21*	SERPINB3_uc002lji.2_Nonsense_Mutation_p.K21*|SERPINB3_uc010dqa.2_Nonsense_Mutation_p.K21*|SERPINB3_uc010dqb.2_Nonsense_Mutation_p.K21*|SERPINB3_uc010dqc.2_Nonsense_Mutation_p.K21*			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	21					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TCTTTTGATTTTCTGAACTGT	0.428000													10	66					0	0	0.008291	0	0
DSEL	92126	broad.mit.edu	37	18	65180318	65180318	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr18:65180318G>T	uc002lke.1	-	2	2782	c.1558C>A	c.(1558-1560)CAG>AAG	p.Q520K		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	510						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				TTATTACACTGGCTTGAGGGT	0.493000													6	24					8.12818e-05	0.000502399	0.001984	1	0
LSR	51599	broad.mit.edu	37	19	35757850	35757850	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr19:35757850C>T	uc002nyl.2	+	8	1491	c.1268C>T	c.(1267-1269)CCC>CTC	p.P423L	LSR_uc002nym.2_Missense_Mutation_p.P404L|LSR_uc002nyn.2_Missense_Mutation_p.P355L|LSR_uc002nyo.2_Missense_Mutation_p.P403L|LSR_uc010xsr.1_Missense_Mutation_p.P315L|LSR_uc002nyp.2_Missense_Mutation_p.P365L|USF2_uc010xss.1_5'Flank|USF2_uc002nyq.1_5'Flank|USF2_uc002nyr.1_5'Flank|USF2_uc002nys.1_5'Flank|USF2_uc002nyt.1_5'Flank|USF2_uc002nyu.1_5'Flank|USF2_uc002nyv.1_5'Flank	NM_205834	NP_991403	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	423	Cytoplasmic (Potential).				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity				0	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCTGGCCCCCCCAGTGGCCGT	0.622000													10	24					0	0	0.001368	0	0
PRKD2	25865	broad.mit.edu	37	19	47192935	47192935	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr19:47192935G>A	uc002pfh.2	-	15	2172	c.1830C>T	c.(1828-1830)ATC>ATT	p.I610I	PRKD2_uc002pfd.2_5'UTR|PRKD2_uc010eks.2_Silent_p.I13I|PRKD2_uc010ekt.2_5'UTR|PRKD2_uc002pfe.2_Silent_p.I130I|PRKD2_uc002pff.2_Silent_p.I130I|PRKD2_uc002pfg.2_Silent_p.I453I|PRKD2_uc002pfi.2_Silent_p.I610I|PRKD2_uc002pfj.2_Silent_p.I610I|PRKD2_uc010xye.1_Silent_p.I610I|PRKD2_uc002pfk.2_Silent_p.I453I	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	610	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CCAGGTTCACGATCCCGGGAT	0.587000													40	44					0	0	0.002852	0	0
APOB	338	broad.mit.edu	37	2	21232428	21232428	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr2:21232428C>T	uc002red.2	-	26	7440	c.7312G>A	c.(7312-7314)GAA>AAA	p.E2438K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2438					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCATTGGTTTCATCTACAAAC	0.323000													332	270					0	0	0.003610	0	0
AGBL5	60509	broad.mit.edu	37	2	27280274	27280274	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr2:27280274C>T	uc002rie.2	+	9	1856	c.1639C>T	c.(1639-1641)CCC>TCC	p.P547S	AGBL5_uc002rid.2_Missense_Mutation_p.P547S|AGBL5_uc002rif.2_RNA	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1	547					protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCGGCTTTCCCCTCCAGATA	0.522000													46	28					0	0	0.003610	0	0
SLC4A5	57835	broad.mit.edu	37	2	74460550	74460550	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr2:74460550G>A	uc002sko.1	-	18	2576	c.2574C>T	c.(2572-2574)AAC>AAT	p.N858N	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Silent_p.N858N|SLC4A5_uc010ffc.1_Silent_p.N858N|SLC4A5_uc002skp.1_Silent_p.N756N|SLC4A5_uc002sks.1_Silent_p.N820N	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	858	Extracellular (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						TCTCCTTCCGGTTGACAATGA	0.532000													22	54					0	0	0.003954	0	0
LRP2	4036	broad.mit.edu	37	2	169995204	169995204	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr2:169995204G>A	uc002ues.2	-	75	13614	c.13401C>T	c.(13399-13401)CTC>CTT	p.L4467L		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4467	Cytoplasmic (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AGGGCTTGACGAGACTGCTTA	0.408000													11	23					0	0	0.001368	0	0
LRP2	4036	broad.mit.edu	37	2	170019096	170019096	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr2:170019096G>A	uc002ues.2	-	63	11986	c.11773C>T	c.(11773-11775)CCT>TCT	p.P3925S		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	3925	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAAGGTTTAGGGGTCGGTTTT	0.388000													15	31					0	0	0.004990	0	0
PLCL1	5334	broad.mit.edu	37	2	198950307	198950307	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr2:198950307G>A	uc010fsp.2	+	2	2357	c.2066G>A	c.(2065-2067)GGG>GAG	p.G689E	PLCL1_uc002uuv.3_Missense_Mutation_p.G610E	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	689	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CTTCAAAACGGGGGATGTGGT	0.468000													34	71					0	0	0.003755	0	0
GBX2	2637	broad.mit.edu	37	2	237074899	237074899	+	Silent	SNP	G	A	A	rs113681406		TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr2:237074899G>A	uc002vvw.1	-	2	743	c.705C>T	c.(703-705)AGC>AGT	p.S235S	GBX2_uc010zng.1_3'UTR	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	235				QAAHKEEDPGHALEETPPSSGA -> PGSSQGGRPGPRGGG DPAEQRR (in Ref. 6).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		CCGCGGCGCCGCTGCTCGGCG	0.662000													8	40					0	0	0.003080	0	0
FASTKD5	60493	broad.mit.edu	37	20	3128887	3128887	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr20:3128887G>A	uc002whz.2	-	2	1141	c.830C>T	c.(829-831)TCC>TTC	p.S277F	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	277					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						CTGAGACAAGGATAGATCCTT	0.363000													29	26					0	0	0.006320	0	0
SYCP2	10388	broad.mit.edu	37	20	58476769	58476769	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr20:58476769G>A	uc002yaz.2	-	15	1269	c.1130C>T	c.(1129-1131)TCA>TTA	p.S377L	SYCP2_uc010gju.1_Missense_Mutation_p.S278L	NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	377					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GATTTCTAGTGATGCGTCAAA	0.279000													13	19					0	0	0.001855	0	0
PRIC285	85441	broad.mit.edu	37	20	62192794	62192794	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr20:62192794G>A	uc002yfm.2	-	14	7754	c.6862C>T	c.(6862-6864)CGG>TGG	p.R2288W	PRIC285_uc002yfl.1_Missense_Mutation_p.R1719W	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2288					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GGGGCCTGCCGGATCCGGTGG	0.637000													70	70					0	0	0.003610	0	0
CCDC116	164592	broad.mit.edu	37	22	21990800	21990800	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr22:21990800C>T	uc002zve.2	+	5	1376	c.1283C>T	c.(1282-1284)TCC>TTC	p.S428F		NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	428										ovary(1)|skin(1)	2	Colorectal(54;0.105)					TCTCACTTCTCCAACCGCCTT	0.592000													12	12					0	0	0.001368	0	0
SGSM1	129049	broad.mit.edu	37	22	25264413	25264413	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr22:25264413G>A	uc003abg.2	+	11	1222	c.1065G>A	c.(1063-1065)AAG>AAA	p.K355K	SGSM1_uc003abh.2_Silent_p.K355K|SGSM1_uc010guu.1_Silent_p.K355K|SGSM1_uc003abj.2_Silent_p.K355K|SGSM1_uc003abi.1_Silent_p.K330K	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	355						Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						GCTTCCCCAAGGGCGGGCACC	0.652000													13	42					0	0	0.002450	0	0
HMOX1	3162	broad.mit.edu	37	22	35782755	35782755	+	Silent	SNP	C	T	T	rs148073049	by1000genomes	TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr22:35782755C>T	uc003ant.1	+	3	302	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_002133	NP_002124	P09601	HMOX1_HUMAN	heme oxygenase (decyclizing) 1	74					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			ovary(1)	1					NADH(DB00157)	GCCCAGTCTTCGCCCCTGTCT	0.612000													14	31					0	0	0.003163	0	0
RHOA	387	broad.mit.edu	37	3	49412957	49412957	+	Silent	SNP	G	C	C			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr3:49412957G>C	uc003cwu.2	-	2	342	c.66C>G	c.(64-66)CTC>CTG	p.L22L	RHOA_uc010hku.2_Intron	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	22					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	TGAAGACTATGAGCAAGCATG	0.473000													3	101					0	0	0.004672	0	0
BSN	8927	broad.mit.edu	37	3	49700470	49700470	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr3:49700470G>C	uc003cxe.3	+	7	10993	c.10879G>C	c.(10879-10881)GGC>CGC	p.G3627R		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3627					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCCTGAGGAGGGCCTGTGGCC	0.667000													9	33					0	0	0.008291	0	0
NEK4	6787	broad.mit.edu	37	3	52773466	52773466	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr3:52773466G>A	uc003dfq.3	-	14	2467	c.2278C>T	c.(2278-2280)CAT>TAT	p.H760Y	NEK4_uc011bej.1_Missense_Mutation_p.H671Y|NEK4_uc003dfr.2_Missense_Mutation_p.H714Y	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	760					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TCTTTAAAATGGATTTCCTCT	0.299000													36	50					0	0	0.005524	0	0
TMF1	7110	broad.mit.edu	37	3	69097533	69097533	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr3:69097533G>A	uc003dnn.2	-	2	570	c.323C>T	c.(322-324)ACC>ATC	p.T108I	TMF1_uc011bfx.1_Missense_Mutation_p.T108I	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	108					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		CTTCTGAATGGTCTGGACATC	0.453000													64	110					0	0	0.003610	0	0
A4GNT	51146	broad.mit.edu	37	3	137849889	137849889	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr3:137849889G>A	uc003ers.2	-	2	412	c.210C>T	c.(208-210)TCC>TCT	p.S70S		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	70	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						CAGACTCTACGGAACAGGAGA	0.532000													135	158					0	0	0.003610	0	0
MBNL1	4154	broad.mit.edu	37	3	152150590	152150590	+	Silent	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr3:152150590C>T	uc003ezm.2	+	3	1219	c.430C>T	c.(430-432)CTG>TTG	p.L144L	MBNL1_uc003ezh.2_Silent_p.L144L|MBNL1_uc003ezi.2_Silent_p.L144L|MBNL1_uc003ezj.2_Silent_p.L87L|MBNL1_uc003ezl.2_Silent_p.L144L|MBNL1_uc003ezp.2_Silent_p.L144L|MBNL1_uc003ezn.2_Intron|MBNL1_uc003ezo.2_Intron|MBNL1_uc010hvp.2_Silent_p.L52L	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	144					embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TTCTCCAAGCCTGGTCCCGGC	0.498000													42	110					0	0	0.002522	0	0
HTRA3	94031	broad.mit.edu	37	4	8307709	8307709	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr4:8307709A>G	uc003gla.2	+	9	1412	c.1208A>G	c.(1207-1209)CAA>CGA	p.Q403R		NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	403	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						GGCGGCATCCAAGATGGTGAC	0.647000													4	44					0	0	0.000602	0	0
GPR125	166647	broad.mit.edu	37	4	22390458	22390458	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr4:22390458G>A	uc003gqm.1	-	19	3101	c.2836C>T	c.(2836-2838)CCT>TCT	p.P946S	GPR125_uc010ieo.1_Missense_Mutation_p.P802S|GPR125_uc003gql.1_Missense_Mutation_p.P73S	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	946	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				TTGCGCTCAGGGTGTCTTTTC	0.448000													29	39					0	0	0.008361	0	0
TBC1D19	55296	broad.mit.edu	37	4	26638892	26638892	+	Silent	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr4:26638892C>T	uc003gsf.3	+	5	624	c.354C>T	c.(352-354)ATC>ATT	p.I118I	TBC1D19_uc010iew.2_Silent_p.I118I|TBC1D19_uc011bxu.1_Silent_p.I53I	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	118						intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				AACTGAGTATCCCACTGGCAC	0.303000													15	9					0	0	0.004990	0	0
KDR	3791	broad.mit.edu	37	4	55953824	55953824	+	Silent	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr4:55953824C>T	uc003has.2	-	27	3914	c.3612G>A	c.(3610-3612)GAG>GAA	p.E1204E	KDR_uc003hat.1_Silent_p.E1204E	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1204	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ATACTTCCTCCTCCTCCATAC	0.483000			Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			5	26					0	0	0.000602	0	0
C7	730	broad.mit.edu	37	5	40959604	40959604	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr5:40959604G>C	uc003jmh.2	+	12	1657	c.1543G>C	c.(1543-1545)GGG>CGG	p.G515R	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	515	TSP type-1 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CTGTGTCCAAGGGAAGAAAAC	0.498000													4	13					0	0	0.000602	0	0
GHR	2690	broad.mit.edu	37	5	42689066	42689066	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr5:42689066G>A	uc003jmt.2	+	4	254	c.211G>A	c.(211-213)GAG>AAG	p.E71K	GHR_uc011cpq.1_Intron	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	71	Extracellular (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CTGGACAGATGAGGTTCATCA	0.453000													71	34					0	0	0.003610	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140346636	140346636	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr5:140346636G>A	uc003lii.2	+	1	525	c.285G>A	c.(283-285)ACG>ACA	p.T95T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lih.2_Intron|PCDHAC2_uc011dag.1_Silent_p.T95T	NM_018899	NP_061722	Q9Y5I4	PCDC2_HUMAN	protocadherin alpha subfamily C, 2 isoform 1	95	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACCTGACGAGTGGAGCGC	0.677000													28	6					0	0	0.005443	0	0
GABRA6	2559	broad.mit.edu	37	5	161116024	161116024	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr5:161116024G>A	uc003lyu.2	+	4	633	c.295G>A	c.(295-297)GAG>AAG	p.E99K	GABRA6_uc003lyv.2_5'Flank	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	99	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGGGCCAACTGAGATTCTGAG	0.418000										TCGA Ovarian(5;0.080)			41	18					0	0	0.003214	0	0
ZFP57	346171	broad.mit.edu	37	6	29643801	29643801	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr6:29643801G>A	uc011dlw.1	-	2	310	c.159C>T	c.(157-159)TTC>TTT	p.F53F	ZFP57_uc003nnl.3_Silent_p.F33F	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	25	KRAB.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CTTCCTGGGTGAAATTCACTG	0.393000													40	58					0	0	0.003214	0	0
PLA2G7	7941	broad.mit.edu	37	6	46675875	46675875	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr6:46675875C>T	uc010jzf.2	-	10	1162	c.893G>A	c.(892-894)TGG>TAG	p.W298*	PLA2G7_uc010jzg.1_Intron	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	298					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			TGGAAACATCCATGCATCCAG	0.358000													17	32					0	0	0.007413	0	0
WASF1	8936	broad.mit.edu	37	6	110423339	110423339	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr6:110423339G>A	uc003ptv.1	-	10	1811	c.974C>T	c.(973-975)CCA>CTA	p.P325L	WASF1_uc003ptw.1_Missense_Mutation_p.P325L|WASF1_uc003ptx.1_Missense_Mutation_p.P325L|WASF1_uc003pty.1_Missense_Mutation_p.P325L	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	325	Poly-Pro.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		TGGAGGAGGTGGGGGAGTGGG	0.517000													31	46					0	0	0.003755	0	0
ROS1	6098	broad.mit.edu	37	6	117678055	117678055	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr6:117678055G>A	uc003pxp.1	-	25	4077	c.3878C>T	c.(3877-3879)TCC>TTC	p.S1293F	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1293	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCCAAAATTGGAAACTTCTGT	0.373000			T	GOPC|ROS1	glioblastoma|NSCLC								9	19					0	0	0.006214	0	0
C6orf58	352999	broad.mit.edu	37	6	127911457	127911457	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr6:127911457G>A	uc003qbh.2	+	5	912	c.900G>A	c.(898-900)GTG>GTA	p.V300V		NM_001010905	NP_001010905	Q6P5S2	CF058_HUMAN	hypothetical protein LOC352999 precursor	300						extracellular region					0				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		TTGACAATGTGGATAAATCTA	0.308000													19	31					0	0	0.001523	0	0
ABCB5	340273	broad.mit.edu	37	7	20795159	20795159	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr7:20795159G>A	uc003suw.3	+	19	2897	c.2351G>A	c.(2350-2352)GGA>GAA	p.G784E	ABCB5_uc010kuh.2_Missense_Mutation_p.G1229E	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	784	Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CTGCACAATGGAAAGATAAAG	0.448000													10	10					0	0	0.006214	0	0
BBS9	27241	broad.mit.edu	37	7	33192368	33192368	+	Silent	SNP	T	C	C			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr7:33192368T>C	uc003tdn.1	+	3	681	c.168T>C	c.(166-168)CCT>CCC	p.P56P	BBS9_uc003tdo.1_Silent_p.P56P|BBS9_uc003tdp.1_Silent_p.P56P|BBS9_uc003tdq.1_Silent_p.P56P|BBS9_uc010kwn.1_RNA|BBS9_uc011kan.1_Silent_p.P56P	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	56					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			GCCCCCATCCTGCAAAAACAG	0.383000									Bardet-Biedl_syndrome				3	42					0	0	0.004672	0	0
GPR37	2861	broad.mit.edu	37	7	124386647	124386647	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr7:124386647C>T	uc003vli.2	-	2	2425	c.1774G>A	c.(1774-1776)GAA>AAA	p.E592K		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	592	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GGCGAGAGTTCGAGTTCCGTG	0.483000													20	116					0	0	0.001882	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				28	37					0	0	0.007291	0	0
CSMD1	64478	broad.mit.edu	37	8	3081381	3081381	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr8:3081381C>T	uc011kwk.1	-	28	4747	c.4357G>A	c.(4357-4359)GGA>AGA	p.G1453R	CSMD1_uc011kwj.1_Missense_Mutation_p.G845R|CSMD1_uc003wqe.2_Missense_Mutation_p.G609R	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1453	Extracellular (Potential).|CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGATTCCCTCCACAAGCAGCT	0.493000													5	13					0	0	0.001168	0	0
PENK	5179	broad.mit.edu	37	8	57354022	57354022	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr8:57354022C>T	uc003xsz.2	-	2	694	c.613G>A	c.(613-615)GAG>AAG	p.E205K	PENK_uc003xta.3_Missense_Mutation_p.E205K	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	205					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TTCTGCAGCTCTTTGGCTTCA	0.517000													33	46					0	0	0.003271	0	0
CRH	1392	broad.mit.edu	37	8	67089264	67089264	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr8:67089264C>T	uc003xvy.1	-	2	634	c.449G>A	c.(448-450)AGA>AAA	p.R150K		NM_000756	NP_000747	P06850	CRF_HUMAN	corticotropin releasing hormone precursor	150					female pregnancy|negative regulation of circadian sleep/wake cycle, REM sleep|parturition|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cortisol secretion|signal transduction|synaptic transmission	extracellular region|soluble fraction	neuropeptide hormone activity				0		all_cancers(86;2.58e-06)|all_epithelial(80;6.27e-09)|all_lung(136;0.000414)|Lung NSC(129;0.0011)	Epithelial(68;0.0136)|all cancers(69;0.0507)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)		Corticotropin(DB01285)	CCGCCTTTCTCTCTCCGGTGC	0.677000											OREG0018805	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	7					0	0	0.000978	0	0
TMEM74	157753	broad.mit.edu	37	8	109796863	109796863	+	Silent	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr8:109796863C>T	uc003ymy.1	-	2	570	c.465G>A	c.(463-465)TTG>TTA	p.L155L	TMEM74_uc003ymx.2_Intron	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	transmembrane protein 74	155					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			CTTCAGATATCAAAGATATGG	0.498000													22	30					0	0	0.002299	0	0
CA9	768	broad.mit.edu	37	9	35675829	35675829	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr9:35675829C>T	uc003zxo.3	+	3	547	c.505C>T	c.(505-507)CAG>TAG	p.Q169*	C9orf100_uc003zxl.2_RNA|CA9_uc003zxp.3_Nonsense_Mutation_p.Q169*	NM_001216	NP_001207	Q16790	CAH9_HUMAN	carbonic anhydrase IX precursor	169	Extracellular.|Catalytic.				one-carbon metabolic process	integral to membrane|microvillus membrane|nucleolus	carbonate dehydratase activity|zinc ion binding			ovary(4)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			TATCCGCCCCCAGCTCGCCGC	0.716000													14	1					0	0	0.002450	0	0
OR5C1	392391	broad.mit.edu	37	9	125552169	125552169	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr9:125552169C>A	uc011lzd.1	+	1	958	c.958C>A	c.(958-960)CAG>AAG	p.Q320K		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	320	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						GCAGGGGTCCCAGTGATTGGT	0.597000													20	15					8.10497e-08	5.20805e-07	0.001523	1	0
PPP6C	5537	broad.mit.edu	37	9	127933365	127933365	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr9:127933365T>A	uc004bpg.3	-	2	391	c.170A>T	c.(169-171)CAG>CTG	p.Q57L	PPP6C_uc010mwv.2_Missense_Mutation_p.Q94L|PPP6C_uc010mww.2_Missense_Mutation_p.Q57L|PPP6C_uc011lzr.1_5'UTR	NM_002721	NP_002712	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit isoform	57					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			ovary(1)|skin(1)	2						AAATTTTACCTGTCCATGGAT	0.378000													81	28					0	0	0.003610	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516465	138516465	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr9:138516465G>A	uc010nbd.1	-	5	563	c.309C>T	c.(307-309)TTC>TTT	p.F103F		NM_182974	NP_892019	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	103	Lumenal (Potential).				carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			ovary(1)	1		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		AGCCTGTCATGAAGTGCTTAT	0.443000													25	6					0	0	0.006320	0	0
KCNT1	57582	broad.mit.edu	37	9	138641983	138641983	+	Silent	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr9:138641983G>A	uc011mdq.1	+	3	368	c.294G>A	c.(292-294)AAG>AAA	p.K98K	KCNT1_uc011mdr.1_5'UTR|KCNT1_uc010nbf.2_Silent_p.K50K	NM_020822	NP_065873	Q5JUK3	KCNT1_HUMAN	potassium channel, subfamily T, member 1	98						membrane	binding|calcium-activated potassium channel activity			large_intestine(2)|ovary(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		ACACCTTCAAGGAGCGGCTCA	0.607000													25	2					0	0	0.007291	0	0
ARHGAP6	395	broad.mit.edu	37	X	11200214	11200214	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chrX:11200214C>G	uc004cup.1	-	6	2171	c.1298G>C	c.(1297-1299)CGA>CCA	p.R433P	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Missense_Mutation_p.R433P|ARHGAP6_uc004cum.1_Missense_Mutation_p.R230P|ARHGAP6_uc004cun.1_Missense_Mutation_p.R253P|ARHGAP6_uc010neb.1_Missense_Mutation_p.R255P|ARHGAP6_uc011mif.1_Missense_Mutation_p.R230P	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	433	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						GCTTCCAACTCGGAATATCCC	0.373000													3	77					0	0	0.004672	0	0
CXorf21	80231	broad.mit.edu	37	X	30578040	30578040	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chrX:30578040G>A	uc004dcg.1	-	3	709	c.433C>T	c.(433-435)CCC>TCC	p.P145S		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	145										ovary(1)	1						CTCTCAGAGGGAAAATCTGTT	0.433000													15	3					0	0	0.006122	0	0
DUSP8	1850	broad.mit.edu	37	11	1577819	1577820	+	Frame_Shift_Del	DEL	CG	-	-	rs61747093		TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr11:1577819_1577820delCG	uc001lts.2	-	7	1934_1935	c.1806_1807delCG	c.(1804-1809)CGCGGCfs	p.R602fs		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	602_603					inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		AGCTCCTCGCCGCGCGCGCGCC	0.752													2	4	---	---	---	---					
DNM1L	10059	broad.mit.edu	37	12	32896297	32896297	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr12:32896297delG	uc001rld.2	+	20	2325	c.2164delG	c.(2164-2166)GGAfs	p.G722fs	DNM1L_uc001rle.2_Frame_Shift_Del_p.G696fs|DNM1L_uc001rlf.2_Frame_Shift_Del_p.G685fs|DNM1L_uc010skh.1_Frame_Shift_Del_p.G788fs|DNM1L_uc001rlg.2_Frame_Shift_Del_p.G777fs|DNM1L_uc001rlh.2_Frame_Shift_Del_p.G764fs|DNM1L_uc010ski.1_Frame_Shift_Del_p.G519fs	NM_012062	NP_036192	O00429	DNM1L_HUMAN	dynamin 1-like isoform 1	722	GED.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GGCATTACAAGGAGCCAGTCA	0.323													10	21	---	---	---	---					
CLK3	1198	broad.mit.edu	37	15	74908164	74908164	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr15:74908164delG	uc010uln.1	+	1	830	c.369delG	c.(367-369)GCGfs	p.A123fs	CLK3_uc002ayg.3_Intron|CLK3_uc002ayh.3_Intron|CLK3_uc010ulm.1_Frame_Shift_Del_p.A123fs|CLK3_uc002ayj.3_5'Flank	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	123						acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						TGCCACGGGCGGAGGTCGCAG	0.731													2	4	---	---	---	---					
GNPTG	84572	broad.mit.edu	37	16	1412536	1412537	+	Splice_Site	INS	-	T	T			TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr16:1412536_1412537insT	uc002clm.2	+	8	644	c.609_splice	c.e8+1	p.Q203_splice		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma							extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				CACCCCCCAGGTAAGCGTGCGC	0.653													23	10	---	---	---	---					
CBX4	8535	broad.mit.edu	37	17	77808240	77808241	+	In_Frame_Ins	INS	-	GTG	GTG	rs3833850		TCGA-EE-A29W-06A-11D-A196-08	TCGA-EE-A29W-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	f57a7183-ae50-4516-85d1-da7838f08943	6ef9abc6-ca60-47fd-bb96-d524b15a7ebf	g.chr17:77808240_77808241insGTG	uc002jxe.2	-	5	1363_1364	c.1200_1201insCAC	c.(1198-1203)insCAC	p.400_401insH		NM_003655	NP_003646	O00257	CBX4_HUMAN	chromobox homolog 4	400_401	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			skin(2)	2			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AGGCCGACGGCgtggtggtggt	0.505													4	7	---	---	---	---					
