Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AGRN	375790	broad.mit.edu	37	1	981185	981185	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:981185C>T	uc001ack.1	+	15	2659	c.2609C>T	c.(2608-2610)CCC>CTC	p.P870L		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	870	Laminin EGF-like 2.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TCGTGTAAGCCCGGGGTGGCT	0.672													72	22					0	0	0.000781405	0	0
TNFRSF4	7293	broad.mit.edu	37	1	1148074	1148074	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:1148074G>A	uc001ade.2	-	4	386	c.381C>T	c.(379-381)CCC>CCT	p.P127P	TNFRSF4_uc001adf.2_Silent_p.P131P	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	127	TNFR-Cys 4.|Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CTGGAGGGCAGGGGGCACAGT	0.592													7	0					0	0	0.000274275	0	0
MIB2	142678	broad.mit.edu	37	1	1563922	1563922	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:1563922C>T	uc001agg.2	+	16	2323	c.2196C>T	c.(2194-2196)CTC>CTT	p.L732L	MIB2_uc001agh.2_Silent_p.L718L|MIB2_uc001agi.2_Silent_p.L728L|MIB2_uc001agj.2_Silent_p.L573L|MIB2_uc001agk.2_Silent_p.L667L|MIB2_uc001agl.1_Silent_p.L688L|MIB2_uc001agm.2_Silent_p.L609L|MIB2_uc010nyq.1_Silent_p.L688L|MIB2_uc009vkh.2_Silent_p.L538L|MIB2_uc001agn.2_Silent_p.L364L|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	732	ANK 7.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CGCTGCATCTCGCCGTGCAAC	0.706													15	5					0	0	0.00074312	0	0
MORN1	79906	broad.mit.edu	37	1	2268200	2268200	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:2268200G>A	uc001ajb.1	-	11	1147	c.1126C>T	c.(1126-1128)CCG>TCG	p.P376S	MORN1_uc009vld.2_Missense_Mutation_p.P352S	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	MORN repeat containing 1	376										ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		TACCCAGGCGGGGGCGGCCCC	0.682													8	31					0	0	0.000673444	0	0
PLCH2	9651	broad.mit.edu	37	1	2421304	2421304	+	Missense_Mutation	SNP	G	A	A	rs35724516		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:2421304G>A	uc001aji.1	+	10	1787	c.1513G>A	c.(1513-1515)GAT>AAT	p.D505N	PLCH2_uc010nyz.1_Missense_Mutation_p.D293N|PLCH2_uc009vle.1_Missense_Mutation_p.D293N|PLCH2_uc001ajj.1_Missense_Mutation_p.D293N|PLCH2_uc001ajk.1_Missense_Mutation_p.D293N	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	505					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CCTCAATGGGGATGTGAGTCG	0.592													50	26					0	0	0.000781405	0	0
RERE	473	broad.mit.edu	37	1	8425888	8425888	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:8425888G>A	uc001ape.2	-	14	2241	c.1431C>T	c.(1429-1431)CCC>CCT	p.P477P	RERE_uc001apf.2_Silent_p.P477P|RERE_uc010nzx.1_Silent_p.P209P|RERE_uc001apd.2_5'UTR	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	477					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CACTGGACGGGGGTCTGGAGG	0.637													54	2					0	0	0.000781405	0	0
SLC2A5	6518	broad.mit.edu	37	1	9100210	9100210	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:9100210C>T	uc001apo.2	-	6	902	c.610G>A	c.(610-612)GCG>ACG	p.A204T	SLC2A5_uc010nzy.1_Missense_Mutation_p.A145T|SLC2A5_uc010nzz.1_Missense_Mutation_p.A89T|SLC2A5_uc010oaa.1_Missense_Mutation_p.A160T|SLC2A5_uc010oab.1_Missense_Mutation_p.A204T	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	204	Helical; Name=6; (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AGCTGCAGCGCCGCGGGGACC	0.682													3	0					0	0	6.4e-05	0	0
H6PD	9563	broad.mit.edu	37	1	9324630	9324630	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:9324630T>C	uc001apt.2	+	5	2351	c.2078T>C	c.(2077-2079)ATG>ACG	p.M693T		NM_004285	NP_004276	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase precursor	693	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding				0	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CTGCTGGGCATGGGTGCCGAC	0.677													84	8					0	0	0.000781405	0	0
CASZ1	54897	broad.mit.edu	37	1	10714564	10714564	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:10714564C>T	uc001aro.2	-	10	2070	c.1750G>A	c.(1750-1752)GAC>AAC	p.D584N	CASZ1_uc001arp.1_Missense_Mutation_p.D584N|CASZ1_uc009vmx.2_Missense_Mutation_p.D608N	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TGGAAGCCGTCGTTAATGAGC	0.572													147	12					0	0	0.000781405	0	0
MTOR	2475	broad.mit.edu	37	1	11190630	11190630	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:11190630C>T	uc001asd.2	-	39	5690	c.5569G>A	c.(5569-5571)GAG>AAG	p.E1857K	MTOR_uc001asc.2_Missense_Mutation_p.E62K	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	1857	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						GGGCTGTTCTCGGTGCTCTCG	0.393													59	7					0	0	0.000781405	0	0
UBIAD1	29914	broad.mit.edu	37	1	11334047	11334047	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:11334047C>T	uc001asg.2	+	1	793	c.459C>T	c.(457-459)TCC>TCT	p.S153S		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	153	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		ACTACCTGTCCCCTCTGAAAC	0.557													43	11					0	0	0.000781405	0	0
MIIP	60672	broad.mit.edu	37	1	12082369	12082369	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:12082369C>T	uc001ato.1	+	3	512	c.332C>T	c.(331-333)CCC>CTC	p.P111L		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	111										ovary(1)	1						CGACCGAGACCCCACTCAGCA	0.682													47	4					0	0	0.000781405	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12921509	12921509	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:12921509C>T	uc001aum.1	+	4	1387	c.1300C>T	c.(1300-1302)CGG>TGG	p.R434W		NM_023014	NP_075390	O60811	PRAM2_HUMAN	PRAME family member 2	434											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACCCCACTTCGGGCTGAGCT	0.557													86	18					0	0	0.000781405	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939636	12939636	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:12939636C>T	uc001aun.2	-	4	1237	c.1166G>A	c.(1165-1167)GGA>GAA	p.G389E		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	389	LRR 6.									ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GATGGGATTTCCACAGAAGCT	0.522													222	29					0	0	0.000781405	0	0
CROCC	9696	broad.mit.edu	37	1	17265513	17265513	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:17265513C>T	uc001azt.2	+	12	1553	c.1484C>T	c.(1483-1485)CCA>CTA	p.P495L	CROCC_uc009voy.1_Missense_Mutation_p.P198L|CROCC_uc009voz.1_Missense_Mutation_p.P258L|CROCC_uc001azu.2_5'Flank	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	495					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		ACCCCGTCCCCACCGCGGCGC	0.746													17	1					0	0	0.000566183	0	0
TAS1R2	80834	broad.mit.edu	37	1	19181252	19181252	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:19181252C>T	uc001bba.1	-	3	713	c.712G>A	c.(712-714)GAG>AAG	p.E238K		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	238	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GGCAGCGTCTCCTGGAAGGCG	0.642													16	13					0	0	0.000422831	0	0
KIAA0090	23065	broad.mit.edu	37	1	19566418	19566418	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:19566418G>A	uc001bbo.2	-	8	891	c.848C>T	c.(847-849)CCA>CTA	p.P283L	KIAA0090_uc001bbp.2_Missense_Mutation_p.P283L|KIAA0090_uc001bbq.2_Missense_Mutation_p.P283L|KIAA0090_uc001bbr.2_Missense_Mutation_p.P261L	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	283	Extracellular (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		AGCGTCCACTGGGTTGGGCTG	0.532													16	46					0	0	0.000308642	0	0
HSPG2	3339	broad.mit.edu	37	1	22173922	22173922	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:22173922G>A	uc001bfj.2	-	62	8129	c.8089C>T	c.(8089-8091)CGG>TGG	p.R2697W	HSPG2_uc009vqd.2_Missense_Mutation_p.R2698W	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2697	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	TTGTTGGCCCGGCACACATAC	0.632													31	95					0	0	0.0024448	0	0
ZBTB40	9923	broad.mit.edu	37	1	22828003	22828003	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:22828003G>C	uc001bft.2	+	5	1361	c.850G>C	c.(850-852)GAG>CAG	p.E284Q	ZBTB40_uc001bfu.2_Missense_Mutation_p.E284Q|ZBTB40_uc009vqi.1_Intron|ZBTB40_uc001bfv.1_5'Flank	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	284					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GAAATGTTTCGAGGGTGAAGG	0.453													10	36					0	0	0.000978159	0	0
ASAP3	55616	broad.mit.edu	37	1	23757530	23757530	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:23757530G>A	uc001bha.2	-	24	2759	c.2635C>T	c.(2635-2637)CCG>TCG	p.P879S	ASAP3_uc001bgy.1_Missense_Mutation_p.P383S|ASAP3_uc001bgz.1_RNA|ASAP3_uc010odz.1_Missense_Mutation_p.P769S|ASAP3_uc010oea.1_Missense_Mutation_p.P870S|ASAP3_uc001bhb.2_Intron	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	879					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						GTTCCTACCGGCACGTTCCTT	0.647													3	13					0	0	0.00024832	0	0
MYOM3	127294	broad.mit.edu	37	1	24388451	24388451	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:24388451C>T	uc001bin.3	-	33	4082	c.3919G>A	c.(3919-3921)GAT>AAT	p.D1307N	MYOM3_uc001bil.3_Missense_Mutation_p.D200N|MYOM3_uc001bim.3_Missense_Mutation_p.D964N	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	1307										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CCTGAGAGATCTGTTGAGAGC	0.443													33	115					0	0	0.000692331	0	0
MYOM3	127294	broad.mit.edu	37	1	24426247	24426247	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:24426247C>T	uc001bin.3	-	6	742	c.579G>A	c.(577-579)CGG>CGA	p.R193R	MYOM3_uc001bio.2_Silent_p.R193R|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	193	Ig-like C2-type 1.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GGGGATCAATCCGTGTGTCAT	0.388													14	50					0	0	0.00074312	0	0
CATSPER4	378807	broad.mit.edu	37	1	26524252	26524252	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:26524252C>T	uc010oez.1	+	4	535	c.535C>T	c.(535-537)CCC>TCC	p.P179S	CATSPER4_uc010oey.1_Intron|CATSPER4_uc009vsf.2_RNA	NM_198137	NP_937770	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4	179	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		AATCAATATTCCCTCCATCAA	0.522													36	19					0	0	0.00222228	0	0
ARID1A	8289	broad.mit.edu	37	1	27100350	27100350	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:27100350C>T	uc001bmv.1	+	17	4435	c.4062C>T	c.(4060-4062)TTC>TTT	p.F1354F	ARID1A_uc001bmt.1_Silent_p.F1353F|ARID1A_uc001bmu.1_Silent_p.F1354F|ARID1A_uc001bmw.1_Silent_p.F971F|ARID1A_uc001bmx.1_Silent_p.F200F|ARID1A_uc009vsm.1_5'UTR|ARID1A_uc009vsn.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1354	Gln-rich.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCAGCCCCTTCCCCAGCCAGC	0.522			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								157	90					0	0	0.000781405	0	0
FAM46B	115572	broad.mit.edu	37	1	27339028	27339028	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:27339028G>A	uc010ofj.1	-	1	306	c.134C>T	c.(133-135)CCC>CTC	p.P45L		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	45										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		GTGCCGTCCGGGGAAGGCCGA	0.453													4	19					0	0	0.00024832	0	0
MAP3K6	9064	broad.mit.edu	37	1	27688716	27688716	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:27688716G>A	uc001bny.1	-	9	1530	c.1281C>T	c.(1279-1281)GCC>GCT	p.A427A	MAP3K6_uc009vsw.1_Silent_p.A419A|MAP3K6_uc001bnz.1_5'Flank	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	427					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGCCTTTGCGGGCCAGCAGGC	0.627													9	34					0	0	0.00136819	0	0
FGR	2268	broad.mit.edu	37	1	27949630	27949630	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:27949630G>A	uc001boj.2	-	2	398	c.252C>T	c.(250-252)GCC>GCT	p.A84A	FGR_uc001bok.2_Silent_p.A84A|FGR_uc001bol.2_Silent_p.A84A|FGR_uc001bom.2_Silent_p.A84A	NM_005248	NP_005239	P09769	FGR_HUMAN	proto-oncogene tyrosine-protein kinase FGR	84	SH3.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			skin(2)	2		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGTCATACAGGGCAATGAACA	0.557													9	51					0	0	0.000673444	0	0
PUM1	9698	broad.mit.edu	37	1	31409621	31409621	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:31409621C>T	uc001bsi.1	-	21	3411	c.3298G>A	c.(3298-3300)GAG>AAG	p.E1100K	PUM1_uc001bsf.1_Missense_Mutation_p.E768K|PUM1_uc001bsg.1_Missense_Mutation_p.E834K|PUM1_uc001bsh.1_Missense_Mutation_p.E1102K|PUM1_uc001bsj.1_Missense_Mutation_p.E1076K|PUM1_uc010oga.1_Missense_Mutation_p.E958K|PUM1_uc001bsk.1_Missense_Mutation_p.E1138K|PUM1_uc010ogb.1_Missense_Mutation_p.E1041K|SNORD103A_uc009vts.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2	1100	PUM-HD.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GTGCACACCTCATCGATGAGC	0.507													68	29					0	0	0.000781405	0	0
TINAGL1	64129	broad.mit.edu	37	1	32051447	32051447	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:32051447G>A	uc001bta.2	+	10	1313	c.1187G>A	c.(1186-1188)CGG>CAG	p.R396Q	TINAGL1_uc001bsz.2_Missense_Mutation_p.R251Q|TINAGL1_uc010ogj.1_Missense_Mutation_p.R365Q|TINAGL1_uc010ogk.1_Missense_Mutation_p.R396Q	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	396					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		AGATACCGCCGGCATGGGACC	0.502													10	9					0	0	0.000673444	0	0
TINAGL1	64129	broad.mit.edu	37	1	32052509	32052509	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:32052509G>A	uc001bta.2	+	12	1459	c.1333G>A	c.(1333-1335)GAG>AAG	p.E445K	TINAGL1_uc001bsz.2_Missense_Mutation_p.E300K|TINAGL1_uc010ogj.1_Missense_Mutation_p.E414K	NM_022164	NP_071447	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	445					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity				0		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		CGGCGTCAATGAGTGCGACAT	0.597													9	4					0	0	0.000673444	0	0
BAI2	576	broad.mit.edu	37	1	32207543	32207543	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:32207543C>T	uc001btn.2	-	9	1797	c.1443G>A	c.(1441-1443)TGG>TGA	p.W481*	BAI2_uc010ogo.1_Nonsense_Mutation_p.W123*|BAI2_uc010ogp.1_Nonsense_Mutation_p.W414*|BAI2_uc010ogq.1_Nonsense_Mutation_p.W481*|BAI2_uc001bto.2_Nonsense_Mutation_p.W481*|BAI2_uc001btq.1_Nonsense_Mutation_p.W414*|BAI2_uc010ogr.1_Nonsense_Mutation_p.W414*	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	481	TSP type-1 4.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		TCCACGCATTCCATGGCCCCC	0.642													57	29					0	0	0.000781405	0	0
CSMD2	114784	broad.mit.edu	37	1	34052167	34052167	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:34052167C>T	uc001bxn.1	-	47	7023	c.6994G>A	c.(6994-6996)GAA>AAA	p.E2332K	CSMD2_uc001bxm.1_Missense_Mutation_p.E2330K	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2332	Sushi 13.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTCAGAATTTCATTCCCCACT	0.478													48	23					0	0	0.000781405	0	0
CSMD2	114784	broad.mit.edu	37	1	34174710	34174710	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:34174710G>A	uc001bxn.1	-	22	3464	c.3435C>T	c.(3433-3435)CTC>CTT	p.L1145L	CSMD2_uc001bxm.1_Silent_p.L1185L|CSMD2_uc001bxo.1_Silent_p.L58L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1145	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CTCCTTCGGAGAGTTCGAATG	0.433													72	44					0	0	0.000781405	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370262	35370262	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:35370262C>T	uc001byc.2	-	1	723	c.723G>A	c.(721-723)AGG>AGA	p.R241R		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	241					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				TGCTCTTGCTCCTCTTGCCGT	0.532													79	34					0	0	0.000781405	0	0
ZMYM1	79830	broad.mit.edu	37	1	35563145	35563145	+	Silent	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:35563145A>C	uc001bym.2	+	5	545	c.397A>C	c.(397-399)AGA>CGA	p.R133R	ZMYM1_uc001byl.1_Silent_p.R133R|ZMYM1_uc009vus.1_RNA|ZMYM1_uc001byn.2_Silent_p.R133R|ZMYM1_uc010ohu.1_Silent_p.R133R|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Silent_p.R58R	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	133	MYM-type 1.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TCCTTCTAAGAGAACTTGTTC	0.368													16	90					0	0	0.000422831	0	0
EIF2C1	26523	broad.mit.edu	37	1	36360795	36360796	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:36360795_36360796CC>TT	uc001bzl.2	+	8	1158_1159	c.945_946CC>TT	c.(943-948)AACCTT>AATTTT	p.L316F	EIF2C1_uc001bzk.2_Missense_Mutation_p.L241F|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	316	PAZ.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGAAATATAACCTTCAGCTCAA	0.505													18	49					0	0	6.4e-05	0	0
RSPO1	284654	broad.mit.edu	37	1	38079995	38079995	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:38079995G>A	uc001cbl.1	-	6	1085	c.297C>T	c.(295-297)ATC>ATT	p.I99I	RSPO1_uc001cbm.1_Silent_p.I99I|RSPO1_uc009vvf.1_Silent_p.I72I|RSPO1_uc009vvg.1_Silent_p.I99I	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	99	FU 2.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACAGTGCTCGATCTTGCATT	0.577													46	20					0	0	0.000781405	0	0
MTF1	4520	broad.mit.edu	37	1	38323218	38323218	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:38323218G>A	uc001cce.1	-	2	254	c.113C>T	c.(112-114)TCC>TTC	p.S38F	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	38						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TCCAGATGAGGAAGGCACCAG	0.478													26	72					0	0	0.00127121	0	0
NT5C1A	84618	broad.mit.edu	37	1	40131815	40131815	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:40131815C>T	uc001cdq.1	-	2	229	c.229G>A	c.(229-231)GAG>AAG	p.E77K		NM_032526	NP_115915	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	77					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			ovary(1)	1	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ACGTACTCCTCCACGCCCTGC	0.552													16	65					0	0	0.00152264	0	0
KCNQ4	9132	broad.mit.edu	37	1	41300637	41300637	+	Splice_Site	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:41300637A>C	uc001cgh.1	+	12	1696	c.1614_splice	c.e12-2	p.R538_splice	KCNQ4_uc001cgi.1_Splice_Site_p.R484_splice	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein						sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			CTCCCCCAACAGGATTCTCAA	0.557													51	26					0	0	0.000781405	0	0
SCMH1	22955	broad.mit.edu	37	1	41608760	41608760	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:41608760A>G	uc001cgo.2	-	6	483	c.172T>C	c.(172-174)TTC>CTC	p.F58L	SCMH1_uc010ojr.1_Missense_Mutation_p.F11L|SCMH1_uc001cgp.2_5'UTR|SCMH1_uc001cgr.2_5'UTR|SCMH1_uc001cgs.2_Missense_Mutation_p.F68L|SCMH1_uc001cgt.2_5'UTR|SCMH1_uc001cgq.2_Missense_Mutation_p.F11L|SCMH1_uc010ojs.1_RNA	NM_001031694	NP_001026864	Q96GD3	SCMH1_HUMAN	sex comb on midleg 1 isoform 1	58	MBT 1.				anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				CTGATCTTGAACTCGTTGCTT	0.473													84	43					0	0	0.000781405	0	0
EDN2	1907	broad.mit.edu	37	1	41948200	41948200	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:41948200C>G	uc001cgx.2	-	3	353	c.281G>C	c.(280-282)AGG>ACG	p.R94T	EDN2_uc001cgu.2_RNA|EDN2_uc001cgv.2_RNA|EDN2_uc009vwh.2_5'UTR|EDN2_uc001cgw.2_RNA|EDN2_uc009vwi.2_Intron|EDN2_uc009vwj.2_Intron	NM_001956	NP_001947	P20800	EDN2_HUMAN	endothelin 2 preproprotein	94					artery smooth muscle contraction|calcium-mediated signaling|cytokine-mediated signaling pathway|elevation of cytosolic calcium ion concentration|hormonal regulation of the force of heart contraction|inositol phosphate-mediated signaling|macrophage activation|macrophage chemotaxis|neutrophil chemotaxis|positive regulation of cell proliferation|positive regulation of heart rate|positive regulation of leukocyte chemotaxis|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of the force of heart contraction by chemical signal|prostaglandin biosynthetic process|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space	endothelin B receptor binding|hormone activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGACAGCGCCTTGGCAGGGA	0.672													91	31					0	0	0.000781405	0	0
TIE1	7075	broad.mit.edu	37	1	43774700	43774700	+	Silent	SNP	C	T	T	rs150072485		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:43774700C>T	uc001ciu.2	+	8	1165	c.1086C>T	c.(1084-1086)TTC>TTT	p.F362F	TIE1_uc010okd.1_Silent_p.F362F|TIE1_uc010oke.1_Silent_p.F317F|TIE1_uc009vwq.2_Silent_p.F318F|TIE1_uc010okf.1_Silent_p.F7F|TIE1_uc010okg.1_Silent_p.F7F|TIE1_uc010okc.1_Intron	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	362	Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AACTGGAGTTCAACTTAGAGA	0.607													49	14					0	0	0.000781405	0	0
MPL	4352	broad.mit.edu	37	1	43805060	43805060	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:43805060C>T	uc001ciw.2	+	4	555	c.510C>T	c.(508-510)CGC>CGT	p.R170R	MPL_uc001civ.2_Silent_p.R170R|MPL_uc009vwr.2_Silent_p.R163R	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	170	Extracellular (Potential).|Fibronectin type-III 1.				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACGAACTCCGCTATGGCCCCA	0.572			Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						57	21					0	0	0.000781405	0	0
KIAA0467	23334	broad.mit.edu	37	1	43893239	43893239	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:43893239C>T	uc001cjk.1	+	11	1402	c.940C>T	c.(940-942)CGT>TGT	p.R314C		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1213						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCCACCATTCCGTCGAGACTT	0.557													30	106					0	0	0.00058488	0	0
IPO13	9670	broad.mit.edu	37	1	44415498	44415498	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:44415498C>T	uc001ckx.2	+	2	1289	c.494C>T	c.(493-495)GCC>GTC	p.A165V		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	165	HEAT 1.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CGCTGCCTAGCCCTGTTAGAG	0.612													20	10					0	0	0.00152264	0	0
KLF17	128209	broad.mit.edu	37	1	44595237	44595237	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:44595237G>A	uc001clp.2	+	2	352	c.294G>A	c.(292-294)ATG>ATA	p.M98I	KLF17_uc009vxf.1_Missense_Mutation_p.M61I	NM_173484	NP_775755	Q5JT82	KLF17_HUMAN	zinc finger protein 393	98					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					AGCGTGGTATGAGCTACTGCC	0.567													89	34					0	0	0.000781405	0	0
PTCH2	8643	broad.mit.edu	37	1	45288151	45288151	+	Nonsense_Mutation	SNP	C	T	T	rs56024410		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:45288151C>T	uc010olf.1	-	22	3560	c.3548G>A	c.(3547-3549)TGG>TAG	p.W1183*	PTCH2_uc010olg.1_Nonsense_Mutation_p.W881*	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	1183	Cytoplasmic (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					AGCAGGGGACCAAGGGGGCTC	0.632									Basal_Cell_Nevus_syndrome				12	52					0	0	0.000978159	0	0
PTCH2	8643	broad.mit.edu	37	1	45295150	45295150	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:45295150G>A	uc010olf.1	-	9	1151	c.1139C>T	c.(1138-1140)TCC>TTC	p.S380F	PTCH2_uc010olg.1_Missense_Mutation_p.S79F	NM_003738	NP_003729	Q9Y6C5	PTC2_HUMAN	patched 2	380	Extracellular (Potential).				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			lung(6)|breast(6)|central_nervous_system(3)|skin(2)|ovary(1)	18	Acute lymphoblastic leukemia(166;0.155)					CAGGGTGGTGGAGGAGAAGGC	0.612									Basal_Cell_Nevus_syndrome				93	45					0	0	0.000781405	0	0
TESK2	10420	broad.mit.edu	37	1	45810872	45810872	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:45810872G>A	uc001cns.1	-	11	1759	c.1356C>T	c.(1354-1356)CGC>CGT	p.R452R	TESK2_uc009vxr.1_Silent_p.R423R|TESK2_uc010olo.1_Silent_p.R369R|TESK2_uc009vxs.1_Silent_p.R244R	NM_007170	NP_009101	Q96S53	TESK2_HUMAN	testis-specific protein kinase 2	452					actin cytoskeleton organization|focal adhesion assembly|spermatogenesis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(2)|pancreas(1)	5	Acute lymphoblastic leukemia(166;0.155)					AACGCCACCGGCGAATAGGTG	0.607													68	23					0	0	0.000781405	0	0
FAAH	2166	broad.mit.edu	37	1	46876082	46876082	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:46876082C>T	uc001cpu.2	+	10	1270	c.1188C>T	c.(1186-1188)TTC>TTT	p.F396F	FAAH_uc001cpv.2_RNA	NM_001441	NP_001432	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	396	Cytoplasmic (By similarity).				fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	AAGGTGATTTCGTGGACCCCT	0.572													67	260					0	0	0.000781405	0	0
CYP4B1	1580	broad.mit.edu	37	1	47280910	47280910	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:47280910C>T	uc001cqm.3	+	8	1128	c.1044C>T	c.(1042-1044)ATC>ATT	p.I348I	CYP4B1_uc009vyl.1_Silent_p.I185I|CYP4B1_uc001cqn.3_Silent_p.I349I|CYP4B1_uc009vym.2_Silent_p.I334I|CYP4B1_uc010omk.1_Silent_p.I185I	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	348					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TCCGCGAGATCCTAGGGGACC	0.582													27	19					0	0	0.00178596	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47650768	47650768	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:47650768C>T	uc001cqw.2	-	3	345	c.178G>A	c.(178-180)GAG>AAG	p.E60K		NM_005764	NP_005755	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	60						integral to membrane					0						TGTGCAGGCTCCCTGGGGATG	0.592													14	59					0	0	0.000422831	0	0
NRD1	4898	broad.mit.edu	37	1	52255268	52255268	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:52255268C>T	uc001ctc.3	-	32	3756	c.3434G>A	c.(3433-3435)GGG>GAG	p.G1145E	NRD1_uc009vzb.2_Missense_Mutation_p.G840E|NRD1_uc001ctd.3_Missense_Mutation_p.G1077E|NRD1_uc001cte.2_Missense_Mutation_p.G1013E	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	1076					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						ACTTCCTGGCCCTCTATGGGC	0.418													53	38					0	0	0.000781405	0	0
PODN	127435	broad.mit.edu	37	1	53546448	53546448	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:53546448C>T	uc001cuv.2	+	9	1712	c.1705C>T	c.(1705-1707)CCC>TCC	p.P569S	PODN_uc001cuw.2_Missense_Mutation_p.P550S|PODN_uc010onr.1_Missense_Mutation_p.P550S|PODN_uc010ons.1_Missense_Mutation_p.P427S	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	521	LRR 17.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						CGAGGGGCTCCCCGAGTCACT	0.522													9	39					0	0	0.000274275	0	0
GLIS1	148979	broad.mit.edu	37	1	54060392	54060392	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:54060392G>A	uc001cvr.1	-	3	751	c.184C>T	c.(184-186)CTG>TTG	p.L62L		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	62					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						CACCGCTTCAGGCTGCCCTCG	0.697													18	14					0	0	0.00152264	0	0
CDCP2	200008	broad.mit.edu	37	1	54618546	54618546	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:54618546C>T	uc001cwv.1	-	1	898	c.50G>A	c.(49-51)GGC>GAC	p.G17D		NM_201546	NP_963840	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2 precursor	17						extracellular region				ovary(1)	1						GAGCCCTGGGCCCAGCAGTGC	0.652													60	47					0	0	0.000781405	0	0
C1orf175	374977	broad.mit.edu	37	1	55158216	55158216	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:55158216G>A	uc010ooe.1	+	16	3155	c.2831G>A	c.(2830-2832)GGA>GAA	p.G944E	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Missense_Mutation_p.G512E|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.G462E|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.G944E|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.G146E|C1orf175_uc001cxu.2_Missense_Mutation_p.G90E	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	944						integral to membrane	binding				0						CACCACCGCGGAGTGGCCTTG	0.612													16	34					0	0	0.000422831	0	0
C1orf175	374977	broad.mit.edu	37	1	55166006	55166006	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:55166006G>A	uc010ooe.1	+	18	3301	c.2977G>A	c.(2977-2979)GAG>AAG	p.E993K	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Nonsense_Mutation_p.W522*|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.E511K|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.E195K	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	993	HEAT 1.					integral to membrane	binding				0						CCTCCAGATGGAGCAGGTGCG	0.622													20	11					0	0	0.00121646	0	0
C1orf168	199920	broad.mit.edu	37	1	57219538	57219538	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:57219538C>T	uc001cym.3	-	8	1607	c.1201G>A	c.(1201-1203)GAA>AAA	p.E401K	C1orf168_uc009vzu.1_Intron|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	401										ovary(3)|skin(2)	5						GAATATGGTTCCTTTTCTGTG	0.353													30	23					0	0	0.00209593	0	0
C8B	732	broad.mit.edu	37	1	57425832	57425832	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:57425832G>A	uc001cyp.2	-	2	177	c.110C>T	c.(109-111)TCC>TTC	p.S37F	C8B_uc010oon.1_5'UTR|C8B_uc010ooo.1_5'UTR	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	37					complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TGACCCAAAGGAATGTGGCCT	0.418													17	78					0	0	0.00074312	0	0
MYSM1	114803	broad.mit.edu	37	1	59147793	59147793	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:59147793G>A	uc009wab.1	-	8	946	c.923C>T	c.(922-924)TCA>TTA	p.S308L	MYSM1_uc001czc.2_RNA	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	308					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					TAATTCAATTGATTTTTTGTC	0.373													103	58					0	0	0.000781405	0	0
INADL	10207	broad.mit.edu	37	1	62330101	62330101	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:62330101G>C	uc001dab.2	+	20	2745	c.2631G>C	c.(2629-2631)GAG>GAC	p.E877D	INADL_uc009waf.1_Missense_Mutation_p.E877D|INADL_uc001daa.2_Missense_Mutation_p.E877D|INADL_uc001dad.3_Missense_Mutation_p.E574D|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	877					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AAGAATATGAGTTATATCAAG	0.438													21	75					0	0	0.00229938	0	0
L1TD1	54596	broad.mit.edu	37	1	62677026	62677026	+	Silent	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:62677026G>C	uc001dae.3	+	4	2882	c.2580G>C	c.(2578-2580)CTG>CTC	p.L860L		NM_019079	NP_061952	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	860										ovary(1)|skin(1)	2						gagaattactggggaatAATA	0.189													22	51					0	0	0.00278032	0	0
DOCK7	85440	broad.mit.edu	37	1	63018492	63018492	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:63018492G>A	uc001daq.2	-	22	2711	c.2677C>T	c.(2677-2679)CGT>TGT	p.R893C	DOCK7_uc001dan.2_Missense_Mutation_p.R785C|DOCK7_uc001dao.2_Missense_Mutation_p.R785C|DOCK7_uc001dap.2_Missense_Mutation_p.R893C|DOCK7_uc001dam.2_Missense_Mutation_p.R73C	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	893					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						CTTCGAGAACGATTTAAATTA	0.443													18	60					0	0	0.000566183	0	0
LEPR	3953	broad.mit.edu	37	1	66036256	66036256	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:66036256C>T	uc001dci.2	+	4	343	c.141C>T	c.(139-141)TTC>TTT	p.F47F	LEPR_uc001dcg.2_Silent_p.F47F|LEPR_uc001dch.2_Silent_p.F47F|LEPR_uc009waq.2_Silent_p.F47F|LEPR_uc001dcj.2_Silent_p.F47F|LEPR_uc001dck.2_Silent_p.F47F	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	47	Extracellular (Potential).				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATGACTACTTCCTTTTGCCTG	0.353													87	45					0	0	0.000781405	0	0
LEPR	3953	broad.mit.edu	37	1	66081851	66081851	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:66081851C>T	uc001dci.2	+	15	2358	c.2156C>T	c.(2155-2157)TCA>TTA	p.S719L	LEPR_uc001dcg.2_Missense_Mutation_p.S719L|LEPR_uc001dch.2_Missense_Mutation_p.S719L|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.S719L|LEPR_uc001dck.2_Missense_Mutation_p.S719L	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	719	Extracellular (Potential).|Fibronectin type-III 3.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GCCATCAATTCAATTGGTGCT	0.403													8	46					0	0	0.000442599	0	0
PDE4B	5142	broad.mit.edu	37	1	66713166	66713166	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:66713166C>T	uc001dcn.2	+	4	496	c.305C>T	c.(304-306)TCC>TTC	p.S102F	PDE4B_uc009war.2_Missense_Mutation_p.S10F|PDE4B_uc001dco.2_Missense_Mutation_p.S102F|PDE4B_uc001dcp.2_Missense_Mutation_p.S87F	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	102					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AATGGCCCTTCCCCAGGTCGG	0.498													174	90					0	0	0.000781405	0	0
TNNI3K	51086	broad.mit.edu	37	1	74905279	74905279	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:74905279G>A	uc001dgf.1	+	20	2035	c.1984G>A	c.(1984-1986)GAA>AAA	p.E662K	TNNI3K_uc001dgd.2_Missense_Mutation_p.E763K|TNNI3K_uc001dge.1_Missense_Mutation_p.E763K	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	662	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						TCTCACTGGCGAAATTCCATT	0.438													23	80					0	0	0.000878237	0	0
SLC44A5	204962	broad.mit.edu	37	1	75684175	75684175	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:75684175C>T	uc001dgu.2	-	17	1673	c.1529G>A	c.(1528-1530)CGA>CAA	p.R510Q	SLC44A5_uc001dgt.2_Missense_Mutation_p.R510Q|SLC44A5_uc001dgs.2_Missense_Mutation_p.R468Q|SLC44A5_uc001dgr.2_Missense_Mutation_p.R468Q|SLC44A5_uc010oqz.1_Missense_Mutation_p.R549Q|SLC44A5_uc010ora.1_Missense_Mutation_p.R504Q|SLC44A5_uc010orb.1_Missense_Mutation_p.R380Q	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	510	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TGAAACTTACCGTATGGCTCG	0.423													102	44					0	0	0.000781405	0	0
AK5	26289	broad.mit.edu	37	1	77763292	77763292	+	Missense_Mutation	SNP	G	A	A	rs141828356		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:77763292G>A	uc001dhn.2	+	4	721	c.464G>A	c.(463-465)CGA>CAA	p.R155Q	AK5_uc001dho.2_Missense_Mutation_p.R129Q|AK5_uc001dhm.1_Missense_Mutation_p.R131Q	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	155					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						ATTGCAGAACGATATGGATTC	0.383													11	66					0	0	0.00136819	0	0
LPHN2	23266	broad.mit.edu	37	1	82409080	82409080	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:82409080C>T	uc001dit.3	+	6	1006	c.825C>T	c.(823-825)GTC>GTT	p.V275V	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Silent_p.V275V|LPHN2_uc001div.2_Silent_p.V275V|LPHN2_uc009wcd.2_Silent_p.V275V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	275	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GTTTATGGGTCATTTACGCCA	0.418													56	26					0	0	0.000781405	0	0
COL24A1	255631	broad.mit.edu	37	1	86289269	86289269	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:86289269C>T	uc001dlj.2	-	45	3781	c.3739G>A	c.(3739-3741)GAA>AAA	p.E1247K	COL24A1_uc001dli.2_Missense_Mutation_p.E383K|COL24A1_uc010osd.1_Missense_Mutation_p.E547K|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1247	Collagen-like 13.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCACCTGGTTCGCCCTTTAGT	0.313													14	76					0	0	0.00185496	0	0
TGFBR3	7049	broad.mit.edu	37	1	92185599	92185599	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:92185599G>A	uc001doh.2	-	9	1730	c.1264C>T	c.(1264-1266)CCT>TCT	p.P422S	TGFBR3_uc009wde.2_Missense_Mutation_p.P199S|TGFBR3_uc010osy.1_Missense_Mutation_p.P380S|TGFBR3_uc001doi.2_Missense_Mutation_p.P421S|TGFBR3_uc001doj.2_Missense_Mutation_p.P421S	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	422	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TTTGGCCGAGGGAGCCCATCT	0.557													109	44					0	0	0.000781405	0	0
ABCA4	24	broad.mit.edu	37	1	94476459	94476459	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:94476459G>A	uc001dqh.2	-	40	5715	c.5611C>T	c.(5611-5613)CAC>TAC	p.H1871Y	ABCA4_uc001dqi.1_5'UTR|ABCA4_uc009wdp.1_Missense_Mutation_p.H139Y	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1871					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AGGTCCCAGTGGAACGGATTT	0.597													43	30					0	0	0.000781405	0	0
ABCA4	24	broad.mit.edu	37	1	94487467	94487467	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:94487467G>A	uc001dqh.2	-	33	4812	c.4708C>T	c.(4708-4710)CCC>TCC	p.P1570S		NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1570	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCCGTGATGGGGACGACTGGG	0.498													60	26					0	0	0.000781405	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650499	94650500	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:94650499_94650500CC>TT	uc001dqj.3	-	18	2406_2407	c.2037_2038GG>AA	c.(2035-2040)AAGGAA>AAAAAA	p.E680K	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.E246K	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	680	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CCATCTGGTTCCTTTTTTGCAA	0.317													19	74					0	0	6.4e-05	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94650528	94650528	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:94650528C>T	uc001dqj.3	-	18	2378	c.2009G>A	c.(2008-2010)GGA>GAA	p.G670E	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dqk.2_Missense_Mutation_p.G236E	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	670					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GAATTCTGCTCCAAATAAGTG	0.348													62	29					0	0	0.000781405	0	0
AMY2B	280	broad.mit.edu	37	1	104115775	104115776	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:104115775_104115776CC>AA	uc001duq.2	+	5	1022_1023	c.406_407CC>AA	c.(406-408)CCT>AAT	p.P136N	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.P136N|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	136					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TTACTTCAACCCTGGAAGTAGG	0.406													13	698					0	0	6.4e-05	0	0
NTNG1	22854	broad.mit.edu	37	1	107979412	107979412	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:107979412G>C	uc001dvh.3	+	7	2099	c.1381G>C	c.(1381-1383)GGC>CGC	p.G461R	NTNG1_uc001dvf.3_Intron|NTNG1_uc010out.1_Missense_Mutation_p.G427R|NTNG1_uc001dvc.3_Intron|NTNG1_uc001dvi.2_Silent_p.T28T|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_Intron|NTNG1_uc009wem.2_Intron	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	461	Laminin EGF-like 3.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CTGGCACTACGGCTGTCAACG	0.522													8	29					0	0	0.000442599	0	0
CLCC1	23155	broad.mit.edu	37	1	109492524	109492525	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:109492524_109492525CC>AA	uc001dwe.1	-	3	240_241	c.148_149GG>TT	c.(148-150)GGG>TTG	p.G50L	AKNAD1_uc010ovb.1_Intron|CLCC1_uc001dwf.1_Missense_Mutation_p.G50L|CLCC1_uc001dwg.1_Missense_Mutation_p.G50L|CLCC1_uc009wes.1_Missense_Mutation_p.G50L|CLCC1_uc009wet.1_Missense_Mutation_p.G50L|CLCC1_uc001dwh.1_Missense_Mutation_p.G50L	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Mid-1-related chloride channel 1 isoform 1	50						endoplasmic reticulum|Golgi apparatus|integral to membrane|nucleus				liver(1)	1		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		ATCCTTTTCCCCTGAAATACCA	0.287													12	401					0	0	6.4e-05	0	0
KIAA1324	57535	broad.mit.edu	37	1	109735476	109735476	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:109735476C>T	uc001dwq.2	+	15	2063	c.1927C>T	c.(1927-1929)CCA>TCA	p.P643S	KIAA1324_uc009wex.1_Missense_Mutation_p.P593S|KIAA1324_uc009wey.2_Missense_Mutation_p.P556S|KIAA1324_uc010ovg.1_Missense_Mutation_p.P541S|KIAA1324_uc001dwr.2_Missense_Mutation_p.P293S	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	643	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GCCCTGTGGTCCAGGGACCAA	0.537													150	93					0	0	0.000781405	0	0
CELSR2	1952	broad.mit.edu	37	1	109810212	109810212	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:109810212C>T	uc001dxa.3	+	16	6117	c.6056C>T	c.(6055-6057)CCC>CTC	p.P2019L		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	2019	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GGGTGGCTCCCCCCAAACCTC	0.587													84	340					0	0	0.000781405	0	0
SYPL2	284612	broad.mit.edu	37	1	110019561	110019561	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:110019561C>A	uc001dxp.2	+	4	784	c.418C>A	c.(418-420)CAC>AAC	p.H140N	SYPL2_uc001dxo.2_Missense_Mutation_p.H140N|SYPL2_uc010ovk.1_Missense_Mutation_p.H140N|SYPL2_uc001dxq.2_Missense_Mutation_p.H48N	NM_001040709	NP_001035799	Q5VXT5	SYPL2_HUMAN	mitsugumin 29	140	Cytoplasmic (Potential).|MARVEL.					integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		CCTGCGCTTCCACAACCTCTA	0.542													10	406					0.00010058	0.000340798	0.00136819	1	0
AMIGO1	57463	broad.mit.edu	37	1	110050499	110050499	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:110050499C>T	uc001dxx.3	-	2	1418	c.1036G>A	c.(1036-1038)GAG>AAG	p.E346K		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	346	Ig-like C2-type.|Extracellular (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		TTGAAAGTCTCTCCCATGGCA	0.512													53	28					0	0	0.000781405	0	0
AMPD2	271	broad.mit.edu	37	1	110163645	110163645	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:110163645C>T	uc009wfh.1	+	2	552	c.10C>T	c.(10-12)CGT>TGT	p.R4C	AMPD2_uc009wfg.1_Intron|AMPD2_uc001dyb.1_Intron|AMPD2_uc001dyc.1_Missense_Mutation_p.R4C|AMPD2_uc010ovr.1_5'UTR	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	4					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding	p.R4S(1)		ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		CATGAGAAATCGTGGCCAGGG	0.652													21	5					0	0	0.000720815	0	0
KCNA3	3738	broad.mit.edu	37	1	111216889	111216889	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:111216889G>A	uc001dzv.1	-	1	767	c.543C>T	c.(541-543)TCC>TCT	p.S181S		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	181						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGATCTCCTCGGAGAAAATGT	0.667													24	108					0	0	0.000878237	0	0
CHIA	27159	broad.mit.edu	37	1	111861282	111861282	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:111861282G>A	uc001eas.2	+	9	1000	c.897G>A	c.(895-897)GGG>GGA	p.G299G	CHIA_uc001ear.2_Silent_p.G191G|CHIA_uc001eaq.2_Silent_p.G191G|CHIA_uc009wgc.2_Silent_p.G191G|CHIA_uc001eat.2_Silent_p.G138G|CHIA_uc001eav.2_Silent_p.G138G|CHIA_uc001eau.2_Silent_p.G138G|CHIA_uc009wgd.2_Silent_p.G138G	NM_201653	NP_970615	Q9BZP6	CHIA_HUMAN	acidic chitinase isoform c	299					apoptosis|cell wall chitin metabolic process|chitin catabolic process|digestion|immune response|positive regulation of chemokine secretion|production of molecular mediator involved in inflammatory response|response to acid|response to fungus	cytoplasm|extracellular space	cation binding|chitin binding|chitinase activity|kinase binding|lysozyme activity|sugar binding			ovary(1)	1		all_cancers(81;3.23e-05)|all_epithelial(167;1.2e-05)|all_lung(203;0.000154)|Lung NSC(277;0.000304)		Colorectal(144;0.0115)|Lung(183;0.0292)|COAD - Colon adenocarcinoma(174;0.0314)|all cancers(265;0.0477)|Epithelial(280;0.0918)|LUSC - Lung squamous cell carcinoma(189;0.154)		AGGAGTCTGGGATCTGGGCTT	0.517													23	117					0	0	0.00278032	0	0
OVGP1	5016	broad.mit.edu	37	1	111957394	111957394	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:111957394G>A	uc001eba.2	-	11	1785	c.1729C>T	c.(1729-1731)CCC>TCC	p.P577S	OVGP1_uc001eaz.2_Missense_Mutation_p.P539S|OVGP1_uc010owb.1_Missense_Mutation_p.P225S	NM_002557	NP_002548	Q12889	OVGP1_HUMAN	oviductal glycoprotein 1 precursor	577					chitin catabolic process|female pregnancy|single fertilization	transport vesicle	cation binding|chitinase activity			ovary(4)|large_intestine(1)	5		all_cancers(81;8.18e-06)|all_epithelial(167;5.64e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000302)		Lung(183;0.0253)|Colorectal(144;0.033)|all cancers(265;0.0552)|Epithelial(280;0.0802)|COAD - Colon adenocarcinoma(174;0.123)|LUSC - Lung squamous cell carcinoma(189;0.14)		TTTCTGGAGGGGACAGTCACC	0.517													88	49					0	0	0.000781405	0	0
ADORA3	140	broad.mit.edu	37	1	112031393	112031393	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:112031393G>A	uc001ebf.2	-	3	1478	c.711C>T	c.(709-711)ATC>ATT	p.I237I	ADORA3_uc001ebg.3_Silent_p.I156I	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:Variant_position_missing_in_P33765_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	AGTCCCGCTGGATGCCACACC	0.527													7	30					0	0	0.000274275	0	0
WNT2B	7482	broad.mit.edu	37	1	113059861	113059861	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:113059861G>A	uc001ecb.2	+	4	1315	c.800G>A	c.(799-801)CGA>CAA	p.R267Q	WNT2B_uc001eca.2_Missense_Mutation_p.R248Q|WNT2B_uc009wgg.2_Missense_Mutation_p.R175Q	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	267					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACCTGCGGCGACGCTATGAT	0.607													52	18					0	0	0.000781405	0	0
PTPN22	26191	broad.mit.edu	37	1	114380814	114380814	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:114380814G>A	uc001eds.2	-	13	1338	c.1208C>T	c.(1207-1209)CCA>CTA	p.P403L	PTPN22_uc009wgq.2_Missense_Mutation_p.P348L|PTPN22_uc010owo.1_Missense_Mutation_p.P159L|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.P403L|PTPN22_uc009wgs.2_Missense_Mutation_p.P276L|PTPN22_uc001edu.2_Missense_Mutation_p.P403L	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	403					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCCAACTATTGGAAATGCCTT	0.403													17	62					0	0	0.000566183	0	0
SYCP1	6847	broad.mit.edu	37	1	115523998	115523998	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:115523998G>A	uc001efr.2	+	29	2633	c.2424G>A	c.(2422-2424)TGG>TGA	p.W808*	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Nonsense_Mutation_p.W808*|SYCP1_uc009wgw.2_Nonsense_Mutation_p.W783*	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	808					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATTTATTGGAAATTGGATT	0.303													75	50					0	0	0.000781405	0	0
SLC22A15	55356	broad.mit.edu	37	1	116609274	116609274	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:116609274C>T	uc001egb.3	+	11	1629	c.1499C>T	c.(1498-1500)TCG>TTG	p.S500L		NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	500					ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CAGGTGTATTCGTATCGCAGG	0.488													21	12					0	0	0.000586117	0	0
VTCN1	79679	broad.mit.edu	37	1	117699533	117699533	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:117699533G>A	uc001ehb.2	-	3	180	c.108C>T	c.(106-108)TCC>TCT	p.S36S	VTCN1_uc001ehc.2_5'UTR|VTCN1_uc009whf.1_Intron	NM_024626	NP_078902	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation	36	Ig-like V-type 1.|Extracellular (Potential).					integral to membrane|plasma membrane					0	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		TGACTGTGATGGAGTGTCTCC	0.473													11	38					0	0	0.000673444	0	0
SPAG17	200162	broad.mit.edu	37	1	118598527	118598527	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:118598527C>T	uc001ehk.2	-	19	2619	c.2551G>A	c.(2551-2553)GAA>AAA	p.E851K		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	851						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCAACAAGTTCCAAATAATTC	0.318													69	30					0	0	0.000781405	0	0
SPAG17	200162	broad.mit.edu	37	1	118629581	118629581	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:118629581G>A	uc001ehk.2	-	11	1478	c.1410C>T	c.(1408-1410)TCC>TCT	p.S470S		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	470						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTGCTCTGGGGGATGGCTCCC	0.522													26	97					0	0	0.00127121	0	0
PHGDH	26227	broad.mit.edu	37	1	120278013	120278014	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:120278013_120278014CG>AT	uc001ehz.2	+	7	966_967	c.739_740CG>AT	c.(739-741)CGG>ATG	p.R247M	PHGDH_uc009whm.2_Missense_Mutation_p.R145M|PHGDH_uc001eia.2_Missense_Mutation_p.R247M|PHGDH_uc009whn.2_Missense_Mutation_p.R247M|PHGDH_uc001eib.2_Missense_Mutation_p.R213M	NM_006623	NP_006614	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	247					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			ovary(1)	1	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	CGCCCTGCTCCGGGCCCTGCAG	0.629													13	601					0	0	6.4e-05	0	0
ADAM30	11085	broad.mit.edu	37	1	120438381	120438381	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:120438381C>T	uc001eij.2	-	1	733	c.579G>A	c.(577-579)AGG>AGA	p.R193R		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	193					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CAGGAAAGTCCCTTAGCCTCG	0.408													172	551					0	0	0.000781405	0	0
ADAM30	11085	broad.mit.edu	37	1	120438567	120438567	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:120438567C>T	uc001eij.2	-	1	547	c.393G>A	c.(391-393)GGG>GGA	p.G131G		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	131					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CTCGGAGACCCCCCATGCATG	0.463													169	553					0	0	0.000781405	0	0
LOC647121	647121	broad.mit.edu	37	1	121306532	121306532	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:121306532G>A	uc009wht.1	+	1	109	c.80G>A	c.(79-81)GGA>GAA	p.G27E	LOC647121_uc001eiu.1_RNA					Homo sapiens cDNA FLJ46881 fis, clone UTERU3015647, moderately similar to Embigin precursor.												0						GAAGATGGGGGATTTTACTGG	0.403													11	40					0	0	0.00185496	0	0
PDZK1	5174	broad.mit.edu	37	1	145761400	145761400	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:145761400G>A	uc001eon.1	+	8	1310	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	NBPF10_uc001emp.3_Intron|PDZK1_uc001eoo.1_Missense_Mutation_p.E405K|PDZK1_uc010oza.1_Missense_Mutation_p.E294K	NM_002614	NP_002605	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	405	PDZ 4.				carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity				0	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			ATTCATCAAAGAGGTATGGTA	0.458													6	19					0	0	0.000442599	0	0
GJA8	2703	broad.mit.edu	37	1	147380211	147380211	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:147380211C>T	uc001epu.1	+	2	192	c.129C>T	c.(127-129)TTC>TTT	p.F43F		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	43	Helical; (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					CCGCAGAGTTCGTGTGGGGGG	0.592													15	38					0	0	0.000566183	0	0
NBPF14	25832	broad.mit.edu	37	1	148004557	148004557	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:148004557G>A	uc001eqq.2	-	22	2774	c.2757C>T	c.(2755-2757)TTC>TTT	p.F919F	LOC200030_uc010ozz.1_Intron|LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Silent_p.F267F|NBPF14_uc010pac.1_Silent_p.F492F	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	919	NBPF 10.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CTTATTGTGGGAATATGACTC	0.463													29	359					0	0	0.000781405	0	0
NBPF14	25832	broad.mit.edu	37	1	148009508	148009509	+	Missense_Mutation	DNP	CC	AA	AA	rs143363070	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:148009508_148009509CC>AA	uc001eqq.2	-	16	1815_1816	c.1798_1799GG>TT	c.(1798-1800)GGG>TTG	p.G600L	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Missense_Mutation_p.G173L|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	600	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CAACAGCTCCCCGCTGAGCCTG	0.465													13	510					0	0	6.4e-05	0	0
LINGO4	339398	broad.mit.edu	37	1	151773936	151773936	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:151773936G>A	uc001ezf.1	-	2	1435	c.1245C>T	c.(1243-1245)ATC>ATT	p.I415I		NM_001004432	NP_001004432	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	415	Extracellular (Potential).|Ig-like C2-type.					integral to membrane				large_intestine(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CCGACTTTCGGATCAGGGCTG	0.612													44	30					0	0	0.000781405	0	0
THEM5	284486	broad.mit.edu	37	1	151820666	151820666	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:151820666C>G	uc009wnd.2	-	4	699	c.567G>C	c.(565-567)AGG>AGC	p.R189S		NM_182578	NP_872384	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	189							hydrolase activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACTTTTTGAACCTGATGTTGA	0.557													48	33					0	0	0.000781405	0	0
TCHH	7062	broad.mit.edu	37	1	152080064	152080064	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152080064C>T	uc001ezp.2	-	2	5629	c.5629G>A	c.(5629-5631)GAA>AAA	p.E1877K	TCHH_uc009wne.1_Missense_Mutation_p.E1877K	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1877	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AATTTCCTTTCCCGTTCCTGG	0.567													32	71					0	0	0.000692331	0	0
HRNR	388697	broad.mit.edu	37	1	152187684	152187684	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152187684C>T	uc001ezt.1	-	3	6497	c.6421G>A	c.(6421-6423)GGA>AGA	p.G2141R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2141					keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATGACTGTCCTGATCTAGAG	0.587													42	685					0	0	0.000781405	0	0
HRNR	388697	broad.mit.edu	37	1	152187762	152187762	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152187762C>A	uc001ezt.1	-	3	6419	c.6343G>T	c.(6343-6345)GGG>TGG	p.G2115W		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2115	23.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGACTGCCCTGAGCTAGAC	0.587													12	329					0.000175454	0.000593749	0.00152264	1	0
HRNR	388697	broad.mit.edu	37	1	152191013	152191013	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152191013G>A	uc001ezt.1	-	3	3168	c.3092C>T	c.(3091-3093)TCA>TTA	p.S1031L		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1031	12.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCACCCTGAGCCAGACCT	0.597													114	87					0	0	0.000781405	0	0
FLG	2312	broad.mit.edu	37	1	152281741	152281741	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152281741G>A	uc001ezu.1	-	3	5657	c.5621C>T	c.(5620-5622)TCA>TTA	p.S1874L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1874	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGTCTCCTGATTGTTTCTC	0.572									Ichthyosis				200	118					0	0	0.000781405	0	0
FLG	2312	broad.mit.edu	37	1	152282637	152282637	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152282637C>T	uc001ezu.1	-	3	4761	c.4725G>A	c.(4723-4725)CAG>CAA	p.Q1575Q		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1575	Ser-rich.|Filaggrin 9.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGGCCCACCTGTGAGTGTC	0.577									Ichthyosis				115	70					0	0	0.000781405	0	0
FLG	2312	broad.mit.edu	37	1	152285860	152285860	+	Missense_Mutation	SNP	C	T	T	rs145828067		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152285860C>T	uc001ezu.1	-	3	1538	c.1502G>A	c.(1501-1503)CGA>CAA	p.R501Q	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	501	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGAGCTGTCTCGTGCCTGCTC	0.612									Ichthyosis				150	88					0	0	0.000781405	0	0
KPRP	448834	broad.mit.edu	37	1	152732973	152732973	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152732973C>T	uc001fal.1	+	2	967	c.909C>T	c.(907-909)CCC>CCT	p.P303P		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	303	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCTGAACCCATATATAACA	0.597													11	33					0	0	0.00244969	0	0
LCE1E	353135	broad.mit.edu	37	1	152760030	152760030	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:152760030C>T	uc001fan.2	+	2	308	c.255C>T	c.(253-255)TCC>TCT	p.S85S		NM_178353	NP_848130	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	85	Cys-rich.				keratinization						0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCACAGGTCCCACCGTCACA	0.697													19	55					0	0	0.00121646	0	0
NUP210L	91181	broad.mit.edu	37	1	153973397	153973397	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:153973397G>A	uc001fdw.2	-	37	5393	c.5321C>T	c.(5320-5322)TCC>TTC	p.S1774F	NUP210L_uc009woq.2_Missense_Mutation_p.S683F|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1774						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			GAGTACACAGGAAATATTGAT	0.453													123	79					0	0	0.000781405	0	0
UBAP2L	9898	broad.mit.edu	37	1	154229846	154229846	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:154229846C>T	uc001fep.3	+	20	2545	c.2378C>T	c.(2377-2379)CCT>CTT	p.P793L	UBAP2L_uc009wot.2_Missense_Mutation_p.P793L|UBAP2L_uc010pek.1_Missense_Mutation_p.P785L|UBAP2L_uc010pel.1_Missense_Mutation_p.P803L|UBAP2L_uc010pen.1_Missense_Mutation_p.P707L|UBAP2L_uc001feq.2_5'UTR|UBAP2L_uc001fer.2_5'UTR	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	793					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AACCTCCCTCCTGGGGTCCCG	0.473													39	30					0	0	0.0025221	0	0
KCNN3	3782	broad.mit.edu	37	1	154705554	154705554	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:154705554G>A	uc001ffp.2	-	4	1829	c.1515C>T	c.(1513-1515)TTC>TTT	p.F505F	KCNN3_uc001ffo.2_Silent_p.F200F	NM_002249	NP_002240	Q9UGI6	KCNN3_HUMAN	small conductance calcium-activated potassium	510						integral to membrane	calmodulin binding			lung(1)	1	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			CAATGGAAAGGAATGTGATGG	0.522													51	22					0	0	0.000781405	0	0
DCST2	127579	broad.mit.edu	37	1	155002639	155002639	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:155002639C>T	uc001fgm.2	-	7	1178	c.1098G>A	c.(1096-1098)ATG>ATA	p.M366I	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	366	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCACAGCCTCCATGCGCAGGA	0.597													62	40					0	0	0.000781405	0	0
MUC1	4582	broad.mit.edu	37	1	155160214	155160214	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:155160214C>T	uc010pfj.1	-	4	1096	c.690G>A	c.(688-690)ACG>ACA	p.T230T	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_Silent_p.T60T|MUC1_uc001fhz.2_Silent_p.T60T|MUC1_uc010pfb.1_Silent_p.T60T|MUC1_uc010pfc.1_RNA|MUC1_uc009wph.2_Silent_p.T60T|MUC1_uc010pfd.1_Intron|MUC1_uc010pfe.1_RNA|MUC1_uc010pff.1_Intron|MUC1_uc009wpi.2_Silent_p.T60T|MUC1_uc010pfg.1_Intron|MUC1_uc010pfh.1_Silent_p.T206T|MUC1_uc010pfi.1_Silent_p.T206T|MUC1_uc010pfk.1_RNA|MUC1_uc010pfl.1_RNA|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Silent_p.T82T|MUC1_uc001fip.2_Intron|MUC1_uc009wqg.2_Silent_p.T91T|MUC1_uc009wpo.2_Silent_p.T97T|MUC1_uc009wps.2_Silent_p.T118T|MUC1_uc009wpt.2_Silent_p.T121T|MUC1_uc001fic.2_Silent_p.T109T|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Silent_p.T123T|MUC1_uc009wpv.2_Intron|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Intron|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Silent_p.T119T|MUC1_uc001fid.2_Silent_p.T110T|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Silent_p.T144T|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Silent_p.T60T|MUC1_uc001fiq.2_Silent_p.T60T|MUC1_uc009wpz.2_Silent_p.T162T|MUC1_uc010pfn.1_Silent_p.T135T|MUC1_uc009wqa.2_Silent_p.T218T|MUC1_uc010pfo.1_Intron|MUC1_uc010pfp.1_Intron|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Silent_p.T135T|MUC1_uc009wqc.2_Silent_p.T132T|MUC1_uc009wqd.2_Silent_p.T156T|MUC1_uc009wqb.2_Silent_p.T60T|MUC1_uc010pfq.1_Silent_p.T132T|MUC1_uc010pfr.1_Intron|MUC1_uc001fit.2_Silent_p.T60T|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Intron|MUC1_uc009wpm.2_Silent_p.T153T|MUC1_uc009wpp.2_Intron|MUC1_uc010pfs.1_RNA|MUC1_uc001fik.2_Silent_p.T153T|MUC1_uc001fio.2_Intron|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Silent_p.T144T|MUC1_uc001fis.1_Intron			P15941	MUC1_HUMAN	SubName: Full=Mucin 1, cell surface associated;	1135	Extracellular (Potential).|SEA.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CGTCTGAGATCGTCAGGTTAT	0.552			T	IGH@	B-NHL								16	32					0	0	0.000958276	0	0
SCAMP3	10067	broad.mit.edu	37	1	155230384	155230384	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:155230384G>A	uc001fjs.2	-	3	464	c.211C>T	c.(211-213)CCC>TCC	p.P71S	RAG1AP1_uc010pey.1_Intron|SCAMP3_uc001fjr.2_5'Flank|SCAMP3_uc001fju.2_Missense_Mutation_p.P71S|SCAMP3_uc001fjv.2_Missense_Mutation_p.P71S|SCAMP3_uc001fjt.2_Missense_Mutation_p.P45S	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1	71	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TTTCTCGAGGGCTGCAAGGAG	0.527													35	82					0	0	0.00148497	0	0
LMNA	4000	broad.mit.edu	37	1	156105073	156105073	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:156105073C>T	uc001fni.2	+	5	1155	c.906C>T	c.(904-906)CTC>CTT	p.L302L	LMNA_uc001fnf.1_Silent_p.L302L|LMNA_uc001fng.2_Silent_p.L302L|LMNA_uc001fnh.2_Silent_p.L302L|LMNA_uc009wro.1_Silent_p.L302L|LMNA_uc010pgz.1_Silent_p.L190L|LMNA_uc001fnj.2_Silent_p.L221L|LMNA_uc001fnk.2_Silent_p.L203L|LMNA_uc009wrp.2_Missense_Mutation_p.S30F|LMNA_uc010pha.1_5'Flank	NM_170707	NP_733821	P02545	LMNA_HUMAN	lamin A/C isoform 1 precursor	302	Coil 2.|Rod.		L -> P (in MDCL).		cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity|structural molecule activity			ovary(2)	2	Hepatocellular(266;0.158)					TCGACAGCCTCTCTGCCCAGC	0.637									Werner_syndrome|Hutchinson-Gilford_Progeria_Syndrome				40	44					0	0	0.00170553	0	0
FCRL5	83416	broad.mit.edu	37	1	157514299	157514299	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:157514299G>A	uc001fqu.2	-	5	755	c.597C>T	c.(595-597)TTC>TTT	p.F199F	FCRL5_uc009wsm.2_Silent_p.F199F|FCRL5_uc010phv.1_Silent_p.F199F|FCRL5_uc010phw.1_Silent_p.F114F|FCRL5_uc001fqv.1_Silent_p.F199F|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	199	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TGATGGGCTGGAAGGAGCTGG	0.552													67	37					0	0	0.000781405	0	0
FCRL3	115352	broad.mit.edu	37	1	157667079	157667079	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:157667079C>T	uc001frb.2	-	6	987	c.695G>A	c.(694-696)AGC>AAC	p.S232N	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Missense_Mutation_p.S232N|FCRL3_uc009wsn.2_Intron|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Missense_Mutation_p.S232N	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	232	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					GAGGGTCTGGCTATCTCTGAA	0.587													50	39					0	0	0.000781405	0	0
FCRL1	115350	broad.mit.edu	37	1	157773774	157773774	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:157773774G>A	uc001frg.2	-	3	293	c.180C>T	c.(178-180)GCC>GCT	p.A60A	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Silent_p.A60A|FCRL1_uc001fri.2_Silent_p.A60A|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	60	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity	p.A60A(1)		skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTGGGCCCAAGGCCCGGGTGT	0.577													57	34					0	0	0.000781405	0	0
OR10T2	128360	broad.mit.edu	37	1	158368976	158368976	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:158368976G>A	uc010pih.1	-	1	281	c.281C>T	c.(280-282)TCC>TTC	p.S94F		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GGCCATGAAGGAGATGGTCTT	0.478													24	21					0	0	0.00047179	0	0
OR10K2	391107	broad.mit.edu	37	1	158389856	158389856	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:158389856G>A	uc010pii.1	-	1	801	c.801C>T	c.(799-801)TCC>TCT	p.S267S		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					CCTGGCTTGAGGAGTAGTTGG	0.403													51	24					0	0	0.000781405	0	0
SPTA1	6708	broad.mit.edu	37	1	158596768	158596768	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:158596768C>T	uc001fst.1	-	41	5893	c.5694G>A	c.(5692-5694)GAG>GAA	p.E1898E		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1898	Spectrin 18.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TGGAAGAAATCTCTTTGTTCT	0.423													68	59					0	0	0.000781405	0	0
SPTA1	6708	broad.mit.edu	37	1	158607858	158607858	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:158607858G>A	uc001fst.1	-	36	5353	c.5154C>T	c.(5152-5154)TTC>TTT	p.F1718F		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1718	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GATCCTGGAAGAACTGGAACA	0.413													32	86					0	0	0.00058488	0	0
SPTA1	6708	broad.mit.edu	37	1	158641235	158641235	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:158641235C>T	uc001fst.1	-	12	1696	c.1497G>A	c.(1495-1497)CTG>CTA	p.L499L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	499	Spectrin 6.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTCGTTTTCCAGGAAGGCCT	0.488													11	26					0	0	0.00244969	0	0
MNDA	4332	broad.mit.edu	37	1	158819007	158819007	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:158819007G>A	uc001fsz.1	+	7	1404	c.1204G>A	c.(1204-1206)GGA>AGA	p.G402R		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	402					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					AAACAAGGAAGGACCAATGAA	0.318													22	19					0	0	0.00106085	0	0
AIM2	9447	broad.mit.edu	37	1	159043271	159043271	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:159043271C>T	uc001ftj.1	-	2	264	c.19G>A	c.(19-21)GAG>AAG	p.E7K		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	7	DAPIN.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					AAGAGTATCTCCTTGTATTTA	0.373													73	41					0	0	0.000781405	0	0
OR10J3	441911	broad.mit.edu	37	1	159284216	159284216	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:159284216G>A	uc010piu.1	-	1	234	c.234C>T	c.(232-234)ATC>ATT	p.I78I		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	78	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					TATGGGGAATGATGGCCACAG	0.483													55	49					0	0	0.000781405	0	0
OR10J5	127385	broad.mit.edu	37	1	159505776	159505776	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:159505776C>T	uc010piw.1	-	1	22	c.22G>A	c.(22-24)GAA>AAA	p.E8K		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					TCTGACACTTCTGTGAAGTTC	0.363													10	47					0	0	0.000673444	0	0
CRP	1401	broad.mit.edu	37	1	159683350	159683350	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:159683350C>T	uc001ftw.2	-	2	744	c.640G>A	c.(640-642)GGC>AGC	p.G214S	CRP_uc001ftx.1_Missense_Mutation_p.G81S|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	214	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	AACACTTCGCCTTGCACTTCA	0.557													20	47					0	0	0.000958276	0	0
SLAMF8	56833	broad.mit.edu	37	1	159799767	159799767	+	Missense_Mutation	SNP	G	A	A	rs140969397		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:159799767G>A	uc001fue.3	+	2	362	c.152G>A	c.(151-153)CGA>CAA	p.R51Q		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	51	Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					GCTATCTGGCGATCTCTCTGG	0.612													72	127					0	0	0.000781405	0	0
CCDC19	25790	broad.mit.edu	37	1	159860385	159860385	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:159860385G>A	uc001fui.2	-	3	175	c.157C>T	c.(157-159)CCC>TCC	p.P53S	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_5'UTR|CCDC19_uc001ful.2_5'UTR|CCDC19_uc009wtc.1_Missense_Mutation_p.P53S	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	53						mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			AGCACAATGGGGCTGTCGCTC	0.527													62	42					0	0	0.000781405	0	0
KCNJ10	3766	broad.mit.edu	37	1	160011427	160011427	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:160011427G>A	uc001fuw.1	-	2	1046	c.896C>T	c.(895-897)TCC>TTC	p.S299F		NM_002241	NP_002232	P78508	IRK10_HUMAN	potassium inwardly-rectifying channel, subfamily	299	Cytoplasmic (By similarity).					integral to plasma membrane	ATP binding|ATP-activated inward rectifier potassium channel activity			ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGGCAGGTAGGAAGTGCGCAC	0.527													14	28					0	0	0.00185496	0	0
MPZ	4359	broad.mit.edu	37	1	161275690	161275690	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:161275690C>T	uc001gaf.3	-	6	790	c.753G>A	c.(751-753)GGG>GGA	p.G251G	MPZ_uc010pko.1_RNA	NM_000530	NP_000521	P25189	MYP0_HUMAN	myelin protein zero	241	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	structural molecule activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4	all_cancers(52;6.96e-17)|all_hematologic(112;0.093)	Breast(1374;0.181)	BRCA - Breast invasive adenocarcinoma(70;0.00376)			TGCGAGACTCCCCCAGCCCCT	0.607													53	31					0	0	0.000781405	0	0
FCGR3B	2215	broad.mit.edu	37	1	161594362	161594362	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:161594362C>T	uc009wul.2	-	5	919	c.645G>A	c.(643-645)ATG>ATA	p.M215I		NM_000570	NP_000561	O75015	FCG3B_HUMAN	low affinity immunoglobulin gamma Fc region	215					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AAAGGAGTACCATCACCAAGC	0.413													41	26					0	0	0.0025221	0	0
C1orf114	57821	broad.mit.edu	37	1	169391163	169391163	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:169391163G>A	uc001gga.1	-	3	674	c.506C>T	c.(505-507)ACT>ATT	p.T169I	C1orf114_uc001gfz.1_Missense_Mutation_p.T169I|C1orf114_uc009wvq.1_Missense_Mutation_p.T169I|C1orf114_uc001ggb.2_Missense_Mutation_p.T169I|C1orf114_uc001ggc.1_Missense_Mutation_p.T169I	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	169											0	all_hematologic(923;0.208)					AAAAGTAGTAGTGTCTTCTAG	0.353													26	49					0	0	0.00047179	0	0
FMO3	2328	broad.mit.edu	37	1	171073016	171073016	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:171073016C>T	uc001ghi.2	+	3	334	c.223C>T	c.(223-225)CCC>TCC	p.P75S	FMO3_uc001ghh.2_Missense_Mutation_p.P75S|FMO3_uc010pmb.1_Missense_Mutation_p.P55S|FMO3_uc010pmc.1_Intron|MIR1295_hsa-mir-1295|MI0006357_5'Flank	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	75					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTCCCATTTCCCGATGACTT	0.423													20	52					0	0	0.00188189	0	0
FMO1	2326	broad.mit.edu	37	1	171251243	171251243	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:171251243G>A	uc009wvz.2	+	7	1090	c.954G>A	c.(952-954)AAG>AAA	p.K318K	FMO1_uc010pme.1_Silent_p.K255K|FMO1_uc001ghl.2_Silent_p.K318K|FMO1_uc001ghm.2_Silent_p.K318K|FMO1_uc001ghn.2_Silent_p.K318K	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	318					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATACTTCAAAGGAAGAGCCTA	0.433													25	55					0	0	0.00047179	0	0
DNM3	26052	broad.mit.edu	37	1	171890898	171890898	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:171890898C>T	uc001gie.2	+	2	348	c.172C>T	c.(172-174)CCT>TCT	p.P58S	DNM3_uc001gid.3_Missense_Mutation_p.P58S|DNM3_uc009wwb.2_Missense_Mutation_p.P58S|DNM3_uc001gif.2_Missense_Mutation_p.P58S	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	58					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						GGACTTTCTCCCTCGAGGGTC	0.413													6	12					0	0	0.00116845	0	0
SLC9A11	284525	broad.mit.edu	37	1	173523904	173523904	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:173523904G>A	uc001giz.2	-	11	1688	c.1265C>T	c.(1264-1266)TCA>TTA	p.S422L	SLC9A11_uc009wwe.2_Intron|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	422	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						CATCACGTATGAATTTATTCC	0.323													40	121					0	0	0.000781405	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628282	173628282	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:173628282C>T	uc001gja.1	-	2	337	c.276G>A	c.(274-276)GTG>GTA	p.V92V	ANKRD45_uc001gjb.3_Silent_p.V92V	NM_198493	NP_940895	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	108	ANK 1.										0						AAGCTCTAATCACGTCACTTT	0.398													65	52					0	0	0.000781405	0	0
TNR	7143	broad.mit.edu	37	1	175348708	175348708	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:175348708G>A	uc001gkp.1	-	7	2024	c.1943C>T	c.(1942-1944)ACC>ATC	p.T648I	TNR_uc009wwu.1_Missense_Mutation_p.T648I	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	648	Fibronectin type-III 4.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGCCCTGGTGGTTGGACCAAT	0.532													17	11					0	0	0.00121646	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564661	176564661	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:176564661G>A	uc001gkz.2	+	3	3085	c.1921G>A	c.(1921-1923)GAC>AAC	p.D641N	PAPPA2_uc001gky.1_Missense_Mutation_p.D641N|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	641	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CGACTTTGACGACGGAGACTG	0.597													11	37					0	0	0.000978159	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668500	176668500	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:176668500A>T	uc001gkz.2	+	8	4175	c.3011A>T	c.(3010-3012)GAC>GTC	p.D1004V	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1004					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ACTTTCTGTGACATCCCACTC	0.507													37	104					0	0	0.000814825	0	0
PAPPA2	60676	broad.mit.edu	37	1	176740314	176740314	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:176740314G>A	uc001gkz.2	+	17	5877	c.4713G>A	c.(4711-4713)AGG>AGA	p.R1571R	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1571	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GTAAAGTCAGGAAGTAAGTTG	0.458													12	17					0	0	0.00136819	0	0
PAPPA2	60676	broad.mit.edu	37	1	176762724	176762724	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:176762724C>T	uc001gkz.2	+	20	6213	c.5049C>T	c.(5047-5049)ATC>ATT	p.I1683I	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1683	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGTGTGTAATCCCCCCCAGTG	0.468													41	31					0	0	0.000680045	0	0
ASTN1	460	broad.mit.edu	37	1	176926840	176926840	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:176926840G>A	uc001glc.2	-	11	2073	c.1861C>T	c.(1861-1863)CGC>TGC	p.R621C	ASTN1_uc001glb.1_Missense_Mutation_p.R621C|ASTN1_uc001gld.1_Missense_Mutation_p.R621C|ASTN1_uc009wwx.1_Missense_Mutation_p.R621C	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	629	EGF-like 2.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCAGCTTGCGATCTGAAATA	0.537													31	16					0	0	0.00058488	0	0
ASTN1	460	broad.mit.edu	37	1	177030324	177030324	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:177030324G>A	uc001glc.2	-	2	573	c.361C>T	c.(361-363)CAC>TAC	p.H121Y	ASTN1_uc001glb.1_Missense_Mutation_p.H121Y|ASTN1_uc001gld.1_Missense_Mutation_p.H121Y|ASTN1_uc009wwx.1_Missense_Mutation_p.H121Y	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	121					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TGATGAATGTGAAAAAGCAAA	0.522													43	129					0	0	0.000680045	0	0
SOAT1	6646	broad.mit.edu	37	1	179310213	179310213	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:179310213C>T	uc001gml.2	+	7	611	c.548C>T	c.(547-549)ACC>ATC	p.T183I	SOAT1_uc010pni.1_Missense_Mutation_p.T118I|SOAT1_uc001gmm.2_Missense_Mutation_p.T125I|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Missense_Mutation_p.T118I	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	183					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	AAATTTCCTACCGTTGTTTGG	0.423													14	49					0	0	0.00185496	0	0
TDRD5	163589	broad.mit.edu	37	1	179562978	179562978	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:179562978G>A	uc001gnf.1	+	3	866	c.616G>A	c.(616-618)GAA>AAA	p.E206K	TDRD5_uc010pnp.1_Missense_Mutation_p.E206K	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	206	Lotus/OST-HTH 2.				DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						TGTAACAGAGGAAAAGCCGAG	0.453													12	36					0	0	0.00185496	0	0
TDRD5	163589	broad.mit.edu	37	1	179632549	179632549	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:179632549G>A	uc001gnf.1	+	15	2660	c.2410G>A	c.(2410-2412)GGA>AGA	p.G804R	TDRD5_uc010pnp.1_Missense_Mutation_p.G858R|TDRD5_uc001gnh.1_Missense_Mutation_p.G359R	NM_173533	NP_775804	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	804					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			ovary(2)|skin(2)|central_nervous_system(1)	5						CCTTGTAAATGGAACGAAAGT	0.398													30	29					0	0	0.0024448	0	0
FAM163A	148753	broad.mit.edu	37	1	179783223	179783223	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:179783223C>T	uc009wxj.2	+	6	862	c.403C>T	c.(403-405)CCA>TCA	p.P135S	FAM163A_uc001gnj.2_Missense_Mutation_p.P135S|FAM163A_uc009wxk.2_Missense_Mutation_p.P135S	NM_173509	NP_775780	Q96GL9	F163A_HUMAN	hypothetical protein LOC148753	135						integral to membrane				ovary(1)	1						GGGGGGACCCCCATCCCTCAA	0.587													44	34					0	0	0.0025221	0	0
XPR1	9213	broad.mit.edu	37	1	180775261	180775261	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:180775261C>T	uc001goi.2	+	5	703	c.511C>T	c.(511-513)CGT>TGT	p.R171C	XPR1_uc009wxm.2_Missense_Mutation_p.R171C|XPR1_uc009wxn.2_Missense_Mutation_p.R171C	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor	171	SPX.|Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0						GGAAACATCTCGTGGAGCAGA	0.393													31	17					0	0	0.001512	0	0
CACNA1E	777	broad.mit.edu	37	1	181741296	181741296	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:181741296G>A	uc001gow.2	+	37	5233	c.5068G>A	c.(5068-5070)GAG>AAG	p.E1690K	CACNA1E_uc009wxs.2_Missense_Mutation_p.E1578K|CACNA1E_uc001gox.1_Missense_Mutation_p.E916K|CACNA1E_uc009wxt.2_Missense_Mutation_p.E916K	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1690	Extracellular (Potential).|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGGGCAGAACGAGAACGAACG	0.557													36	28					0	0	0.000953801	0	0
RNASEL	6041	broad.mit.edu	37	1	182544549	182544549	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:182544549C>T	uc001gpj.1	-	6	2371	c.2204G>A	c.(2203-2205)GGG>GAG	p.G735E	RNASEL_uc009wxz.1_Missense_Mutation_p.G735E	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	735					mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						GCTGGCCAACCCACTGGCCCC	0.378									Hereditary_Prostate_Cancer				26	86					0	0	0.00209593	0	0
DHX9	1660	broad.mit.edu	37	1	182852480	182852480	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:182852480C>T	uc001gpr.2	+	25	3284	c.3121C>T	c.(3121-3123)CCC>TCC	p.P1041S	DHX9_uc001gps.2_Missense_Mutation_p.P827S|DHX9_uc001gpt.2_Missense_Mutation_p.P320S|DHX9_uc009wyd.2_Missense_Mutation_p.P6S	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	1041					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						GTACCCATCTCCCTTCTTTGT	0.343													26	19					0	0	0.00178596	0	0
RGL1	23179	broad.mit.edu	37	1	183857693	183857693	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:183857693C>T	uc001gqo.2	+	8	1194	c.1037C>T	c.(1036-1038)ACT>ATT	p.T346I	RGL1_uc010pof.1_Missense_Mutation_p.T151I|RGL1_uc001gqm.2_Missense_Mutation_p.T381I|RGL1_uc010pog.1_Missense_Mutation_p.T344I|RGL1_uc010poh.1_Missense_Mutation_p.T344I|RGL1_uc010poi.1_Missense_Mutation_p.T346I	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	346	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						TTAAAAAAGACTTGGGCTGCC	0.468													35	85					0	0	0.0024448	0	0
RGL1	23179	broad.mit.edu	37	1	183857695	183857695	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:183857695T>C	uc001gqo.2	+	8	1196	c.1039T>C	c.(1039-1041)TGG>CGG	p.W347R	RGL1_uc010pof.1_Missense_Mutation_p.W152R|RGL1_uc001gqm.2_Missense_Mutation_p.W382R|RGL1_uc010pog.1_Missense_Mutation_p.W345R|RGL1_uc010poh.1_Missense_Mutation_p.W345R|RGL1_uc010poi.1_Missense_Mutation_p.W347R	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	347	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						AAAAAAGACTTGGGCTGCCGT	0.468													30	83					0	0	0.00106085	0	0
GLT25D2	23127	broad.mit.edu	37	1	183914630	183914630	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:183914630G>A	uc001gqr.2	-	9	1577	c.1205C>T	c.(1204-1206)TCC>TTC	p.S402F	GLT25D2_uc010poj.1_Missense_Mutation_p.S402F|GLT25D2_uc001gqp.2_Missense_Mutation_p.S10F|GLT25D2_uc001gqq.2_Missense_Mutation_p.S139F|GLT25D2_uc001gqs.2_Missense_Mutation_p.S282F	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	402					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						AGGCCTGGAGGAATAGGGATC	0.448													50	107					0	0	0.000781405	0	0
FAM129A	116496	broad.mit.edu	37	1	184792358	184792358	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:184792358G>A	uc001gra.2	-	8	1122	c.928C>T	c.(928-930)CGT>TGT	p.R310C	FAM129A_uc001grb.1_Missense_Mutation_p.R73C|FAM129A_uc009wyh.1_Missense_Mutation_p.R138C|FAM129A_uc009wyi.1_Missense_Mutation_p.R108C	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	310					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						ATGTCAGAACGGATCGTTCCT	0.428													23	46					0	0	0.00047179	0	0
HMCN1	83872	broad.mit.edu	37	1	185934984	185934984	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:185934984G>A	uc001grq.1	+	14	2378	c.2149G>A	c.(2149-2151)GAT>AAT	p.D717N	HMCN1_uc001grr.1_Missense_Mutation_p.D58N	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	717	Ig-like C2-type 4.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGCCCTTGGGGATATAACCGT	0.398													28	73					0	0	0.00283554	0	0
HMCN1	83872	broad.mit.edu	37	1	186022088	186022088	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:186022088C>T	uc001grq.1	+	43	6811	c.6582C>T	c.(6580-6582)CCC>CCT	p.P2194P		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2194					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTCTAGTCCCCCCAAATATTG	0.338													48	44					0	0	0.000781405	0	0
PRG4	10216	broad.mit.edu	37	1	186276646	186276646	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:186276646A>C	uc001gru.3	+	7	1846	c.1795A>C	c.(1795-1797)AAG>CAG	p.K599Q	PRG4_uc001grt.3_Missense_Mutation_p.K558Q|PRG4_uc009wyl.2_Missense_Mutation_p.K506Q|PRG4_uc009wym.2_Missense_Mutation_p.K465Q|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	599	33; approximate.|59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CACCACCAAGAAGCCTGCACC	0.647													21	12					0	0	0.000586117	0	0
TPR	7175	broad.mit.edu	37	1	186303547	186303547	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:186303547G>A	uc001grv.2	-	36	5389	c.5092C>T	c.(5092-5094)CGC>TGC	p.R1698C		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1698					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		ACCATTGGGCGGATACTAGCC	0.468			T	NTRK1	papillary thyroid								5	97					0	0	0.00116845	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186880420	186880420	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:186880420C>T	uc001gsc.2	+	7	662	c.457C>T	c.(457-459)CAG>TAG	p.Q153*	PLA2G4A_uc010pos.1_Intron	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	153	Phospholipid binding (Probable).|PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TCTGTGTGATCAGGAGAAGAC	0.448													55	46					0	0	0.000781405	0	0
CFH	3075	broad.mit.edu	37	1	196694353	196694353	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:196694353G>A	uc001gtj.3	+	12	2039	c.1799G>A	c.(1798-1800)GGA>GAA	p.G600E		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	600	Sushi 10.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGCAAACCAGGATTTACAATA	0.398													35	19					0	0	0.00058488	0	0
DENND1B	163486	broad.mit.edu	37	1	197479641	197479641	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:197479641G>A	uc010ppe.1	-	22	2555	c.2217C>T	c.(2215-2217)TTC>TTT	p.F739F	DENND1B_uc010ppf.1_RNA	NM_001142795	NP_001136267	Q6P3S1	DEN1B_HUMAN	DENN/MADD domain containing 1B isoform 1	Error:Variant_position_missing_in_Q6P3S1_after_alignment						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity				0						AGCTTTGTTGGAAGTCAGATG	0.373													25	42					0	0	0.00278032	0	0
LHX9	56956	broad.mit.edu	37	1	197889293	197889293	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:197889293G>A	uc001guk.1	+	2	803	c.366G>A	c.(364-366)GAG>GAA	p.E122E	LHX9_uc001gui.1_Silent_p.E113E|LHX9_uc001guj.1_Silent_p.E128E	NM_020204	NP_064589	Q9NQ69	LHX9_HUMAN	LIM homeobox 9 isoform 1	122	LIM zinc-binding 1.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						ACTGCAAGGAGGATTACTACA	0.577													27	84					0	0	0.0024448	0	0
CACNA1S	779	broad.mit.edu	37	1	201060870	201060870	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:201060870G>A	uc001gvv.2	-	5	819	c.592C>T	c.(592-594)CAC>TAC	p.H198Y		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	198	I.|Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AGGGCGATGTGAAAGAGGGGG	0.552													11	20					0	0	0.00136819	0	0
SHISA4	149345	broad.mit.edu	37	1	201860657	201860657	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:201860657C>T	uc001gxa.2	+	4	599	c.508C>T	c.(508-510)CCA>TCA	p.P170S		NM_198149	NP_937792	Q96DD7	SHSA4_HUMAN	shisa homolog 4 precursor	170	Cytoplasmic (Potential).|Pro-rich.					integral to membrane					0						TCCCCAATATCCACTCTACCC	0.612													44	42					0	0	0.000781405	0	0
LRRN2	10446	broad.mit.edu	37	1	204588132	204588132	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:204588132G>A	uc001hbe.1	-	3	1377	c.989C>T	c.(988-990)GCC>GTC	p.A330V	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.A330V|LRRN2_uc009xbf.1_Missense_Mutation_p.A330V|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	330	LRR 11.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GTGGTGGAAGGCGCGGGGGTG	0.607													12	10					0	0	0.00136819	0	0
NFASC	23114	broad.mit.edu	37	1	204985599	204985599	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:204985599G>A	uc001hbj.2	+	30	3983	c.3655G>A	c.(3655-3657)GAG>AAG	p.E1219K	NFASC_uc010pra.1_Missense_Mutation_p.E1153K|NFASC_uc001hbi.2_Missense_Mutation_p.E1148K|NFASC_uc010prb.1_Missense_Mutation_p.E1168K|NFASC_uc010prc.1_Missense_Mutation_p.E719K|NFASC_uc001hbl.1_Missense_Mutation_p.E295K|NFASC_uc001hbm.1_Missense_Mutation_p.E242K|NFASC_uc009xbh.1_Silent_p.R73R|NFASC_uc001hbo.1_Silent_p.R94R	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	1326	Cytoplasmic (Potential).				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAAGGACAAGGAGGAAACAGA	0.572													15	39					0	0	0.000566183	0	0
CDK18	5129	broad.mit.edu	37	1	205492680	205492680	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:205492680G>A	uc001hcr.2	+	3	419	c.200G>A	c.(199-201)GGG>GAG	p.G67E	CDK18_uc009xbk.1_RNA|CDK18_uc009xbl.1_RNA|CDK18_uc010pri.1_Silent_p.R87R|CDK18_uc001hcp.2_Missense_Mutation_p.G67E|CDK18_uc001hcq.2_Missense_Mutation_p.G67E|CDK18_uc010prj.1_5'UTR|CDK18_uc001hcs.2_5'UTR|CDK18_uc009xbm.1_5'UTR	NM_212503	NP_997668	Q07002	CDK18_HUMAN	PCTAIRE protein kinase 3 isoform a	65			G -> R.				ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			stomach(2)	2						ACAGACAGCGGGGAGGAGCCG	0.677													5	4					0	0	0.000157383	0	0
MFSD4	148808	broad.mit.edu	37	1	205549071	205549071	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:205549071C>T	uc001hcv.3	+	2	509	c.423C>T	c.(421-423)TTC>TTT	p.F141F	MFSD4_uc010prk.1_Silent_p.F141F|MFSD4_uc010prl.1_RNA|MFSD4_uc010prm.1_Silent_p.F86F	NM_181644	NP_857595	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing	141	Helical; (Potential).				transmembrane transport	integral to membrane				skin(2)|central_nervous_system(1)	3	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CGGCCGTCTTCCTCCAGGTAA	0.672													15	4					0	0	0.000422831	0	0
ELK4	2005	broad.mit.edu	37	1	205592869	205592869	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:205592869G>A	uc001hcy.1	-	2	1392	c.142C>T	c.(142-144)CGC>TGC	p.R48C	ELK4_uc001hcz.2_Missense_Mutation_p.R48C|SLC45A3_uc010prn.1_Missense_Mutation_p.R137C|SLC45A3_uc010pro.1_Missense_Mutation_p.R321C|SLC45A3_uc010prp.1_RNA|ELK4_uc010prq.1_RNA	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	48	ETS.					cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TTGTTCTTGCGAATCCCCCAG	0.448			T	SLC45A3	prostate								102	68					0	0	0.000781405	0	0
C1orf116	79098	broad.mit.edu	37	1	207196695	207196695	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:207196695G>A	uc001hfd.2	-	4	673	c.414C>T	c.(412-414)ATC>ATT	p.I138I	C1orf116_uc009xcb.1_5'UTR	NM_023938	NP_076427	Q9BW04	SARG_HUMAN	specifically androgen-regulated protein isoform	138						cytoplasm|plasma membrane	receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Prostate(682;0.19)					TGGCAATGTGGATATTCCTAG	0.587													39	27					0	0	0.00170553	0	0
CR1L	1379	broad.mit.edu	37	1	207851592	207851592	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:207851592G>A	uc001hga.3	+	3	448	c.327G>A	c.(325-327)GTG>GTA	p.V109V	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	109	Sushi 2.					cytoplasm|extracellular region|membrane					0						TGGCACATGTGATCAAAGACA	0.388													54	40					0	0	0.000781405	0	0
CR1L	1379	broad.mit.edu	37	1	207867858	207867858	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:207867858C>T	uc001hga.3	+	5	745	c.624C>T	c.(622-624)ACC>ACT	p.T208T	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	208	Sushi 3.					cytoplasm|extracellular region|membrane					0						TATACTGCACCAGCAAAGATG	0.468													53	143					0	0	0.000781405	0	0
IRF6	3664	broad.mit.edu	37	1	209964072	209964072	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:209964072G>A	uc001hhq.1	-	7	1091	c.828C>T	c.(826-828)TTC>TTT	p.F276F	IRF6_uc010psm.1_Silent_p.F181F|IRF6_uc009xct.1_Silent_p.F276F	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	276					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CAGGACCTGGGAATTTGACCT	0.567										HNSCC(57;0.16)			35	31					0	0	0.000814825	0	0
RCOR3	55758	broad.mit.edu	37	1	211462668	211462668	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:211462668C>T	uc001hig.2	+	7	864	c.695C>T	c.(694-696)TCC>TTC	p.S232F	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Missense_Mutation_p.S290F|RCOR3_uc010psw.1_Missense_Mutation_p.S290F|RCOR3_uc001hif.2_Missense_Mutation_p.S290F	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		GTAGCAGTTTCCTGTAGTCCC	0.413													20	45					0	0	0.00121646	0	0
INTS7	25896	broad.mit.edu	37	1	212115247	212115247	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:212115247G>A	uc001hiw.1	-	20	2913	c.2808C>T	c.(2806-2808)TCC>TCT	p.S936S	INTS7_uc009xdb.1_Silent_p.S916S|INTS7_uc001hix.1_Silent_p.S812S|INTS7_uc001hiy.1_Silent_p.S922S|INTS7_uc010pta.1_Silent_p.S887S	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	936					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GAATTTGCTGGGAATAAGGGT	0.453													75	38					0	0	0.000781405	0	0
CENPF	1063	broad.mit.edu	37	1	214816005	214816005	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:214816005T>A	uc001hkm.2	+	12	4498	c.4324T>A	c.(4324-4326)TTA>ATA	p.L1442I		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	1538	1-2.|2 X 96 AA approximate tandem repeats.		Missing.		cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGTTGACTCATTAAAGGCCGA	0.423													25	13					0	0	0.000586117	0	0
USH2A	7399	broad.mit.edu	37	1	216061780	216061780	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:216061780G>A	uc001hku.1	-	41	8598	c.8211C>T	c.(8209-8211)CCC>CCT	p.P2737P		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2737	Fibronectin type-III 14.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGACTGCATCGGGTTCCAGCA	0.507										HNSCC(13;0.011)			15	43					0	0	0.00074312	0	0
USH2A	7399	broad.mit.edu	37	1	216373386	216373386	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:216373386C>G	uc001hku.1	-	17	3781	c.3394G>C	c.(3394-3396)GGT>CGT	p.G1132R	USH2A_uc001hkv.2_Missense_Mutation_p.G1132R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1132	Extracellular (Potential).|Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTTGTTGAACCATGCACATTG	0.373										HNSCC(13;0.011)			3	69					0	0	0.00024832	0	0
HHIPL2	79802	broad.mit.edu	37	1	222713516	222713516	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:222713516C>T	uc001hnh.1	-	4	1344	c.1286G>A	c.(1285-1287)GGG>GAG	p.G429E		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	429					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GATGGGGTCCCCTCGGTCCAC	0.577													238	163					0	0	0.000781405	0	0
DISP1	84976	broad.mit.edu	37	1	223116290	223116291	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:223116290_223116291CC>AA	uc001hnu.1	+	2	272_273	c.125_126CC>AA	c.(124-126)CCC>CAA	p.P42Q		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	42					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		CAGCTCACACCCAAAGAAGCAA	0.505													12	543					0	0	6.4e-05	0	0
DISP1	84976	broad.mit.edu	37	1	223176933	223176934	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:223176933_223176934GG>TT	uc001hnu.1	+	8	2341_2342	c.2194_2195GG>TT	c.(2194-2196)GGG>TTG	p.G732L		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	732	Helical; (Potential).				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AACTGTAGGTGGGGCCTACATT	0.426													19	705					0	0	6.4e-05	0	0
TLR5	7100	broad.mit.edu	37	1	223283826	223283826	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:223283826G>A	uc001hnv.1	-	4	2994	c.2548C>T	c.(2548-2550)CCG>TCG	p.P850S	TLR5_uc001hnw.1_Missense_Mutation_p.P850S	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	850	Cytoplasmic (Potential).		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		GTTTGCAACGGAATGTTATTG	0.378													24	76					0	0	0.00178596	0	0
TP53BP2	7159	broad.mit.edu	37	1	223991885	223991885	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:223991885C>T	uc010pvb.1	-	6	932	c.640G>A	c.(640-642)GGG>AGG	p.G214R	TP53BP2_uc001hod.2_Missense_Mutation_p.G85R|TP53BP2_uc010pva.1_5'Flank	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	208					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		CCAAGTTTCCCATTGCTTAGT	0.264													61	189					0	0	0.000781405	0	0
NVL	4931	broad.mit.edu	37	1	224477369	224477369	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:224477369G>A	uc001hok.2	-	13	1435	c.1392C>T	c.(1390-1392)CAC>CAT	p.H464H	NVL_uc001hol.2_Silent_p.H358H|NVL_uc010pvd.1_Silent_p.H373H|NVL_uc010pve.1_Silent_p.H275H|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	464						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		CTGGAGTTAGGTGTGCTAAGT	0.433													17	33					0	0	0.00074312	0	0
LIN9	286826	broad.mit.edu	37	1	226420283	226420283	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:226420283G>A	uc001hqa.2	-	15	1906	c.1596C>T	c.(1594-1596)ATC>ATT	p.I532I	LIN9_uc001hqb.2_Silent_p.I497I|LIN9_uc001hqc.2_Silent_p.I464I	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	516					cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GTGCAACATGGATTTCTACAT	0.313													15	52					0	0	0.00074312	0	0
SNAP47	116841	broad.mit.edu	37	1	227935648	227935648	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:227935648C>T	uc001hrf.2	+	2	760	c.346C>T	c.(346-348)CTG>TTG	p.L116L	SNAP47_uc001hqz.2_Silent_p.L71L|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_Silent_p.L116L|SNAP47_uc001hre.2_Intron|SNAP47_uc001hrg.1_Silent_p.L71L	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	116						endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						CATCACCATCCTGGAGAAGGG	0.532													44	90					0	0	0.000781405	0	0
SNAP47	116841	broad.mit.edu	37	1	227947188	227947188	+	Splice_Site	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:227947188T>C	uc001hrf.2	+	3	1537	c.1123_splice	c.e3+2	p.A375_splice	SNAP47_uc001hqz.2_Splice_Site_p.A330_splice|SNAP47_uc001hra.2_Splice_Site_p.A133_splice|SNAP47_uc001hrd.2_Splice_Site_p.A375_splice|SNAP47_uc001hre.2_Splice_Site_p.A133_splice|SNAP47_uc001hrg.1_Silent_p.G330G	NM_053052	NP_444280	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa							endomembrane system|membrane|perinuclear region of cytoplasm				ovary(1)	1						GGCATGCAGGTTAGTGACCGA	0.527													83	51					0	0	0.000781405	0	0
C1orf69	200205	broad.mit.edu	37	1	228362887	228362887	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:228362887C>T	uc001hsl.3	+	3	833	c.744C>T	c.(742-744)GCC>GCT	p.A248A	C1orf69_uc010pvw.1_Silent_p.A55A	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	248					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CCAACCTGGCCTTCATGAACG	0.642													24	78					0	0	0.000878237	0	0
OBSCN	84033	broad.mit.edu	37	1	228471227	228471227	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:228471227G>A	uc009xez.1	+	33	8805	c.8761G>A	c.(8761-8763)GAG>AAG	p.E2921K	OBSCN_uc001hsn.2_Missense_Mutation_p.E2921K|OBSCN_uc001hsp.1_Missense_Mutation_p.E620K|OBSCN_uc001hsq.1_Missense_Mutation_p.E177K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2921	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CTTCACAGAGGAGCTGACCAA	0.612													27	17					0	0	0.00283554	0	0
OBSCN	84033	broad.mit.edu	37	1	228475871	228475871	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:228475871G>A	uc009xez.1	+	37	9965	c.9921G>A	c.(9919-9921)AAG>AAA	p.K3307K	OBSCN_uc001hsn.2_Silent_p.K3307K|OBSCN_uc001hsq.1_Silent_p.K563K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3307	Ig-like 33.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGTGGAGAAAGGGGTCCGAGA	0.632													30	71					0	0	0.00283554	0	0
OBSCN	84033	broad.mit.edu	37	1	228479646	228479646	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:228479646G>A	uc009xez.1	+	39	10431	c.10387G>A	c.(10387-10389)GAA>AAA	p.E3463K	OBSCN_uc001hsn.2_Missense_Mutation_p.E3463K|OBSCN_uc001hsq.1_Missense_Mutation_p.E719K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3463	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGAGGCCGTGGAAGGGGCCAC	0.582													9	31					0	0	0.000442599	0	0
OBSCN	84033	broad.mit.edu	37	1	228525717	228525717	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:228525717G>A	uc009xez.1	+	67	16917	c.16873G>A	c.(16873-16875)GAA>AAA	p.E5625K	OBSCN_uc001hsn.2_Missense_Mutation_p.E5625K|OBSCN_uc001hsr.1_Missense_Mutation_p.E253K	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	5625	SH3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CACGCTGCGGGAAGGCCAGTA	0.632													14	6					0	0	0.000566183	0	0
OBSCN	84033	broad.mit.edu	37	1	228560448	228560448	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:228560448G>A	uc009xez.1	+	94	22013	c.21969G>A	c.(21967-21969)ATG>ATA	p.M7323I	OBSCN_uc001hsr.1_Missense_Mutation_p.M1952I	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7323					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCGAGTTTATGATCTTCAGGA	0.607													13	8					0	0	0.00185496	0	0
TRIM11	81559	broad.mit.edu	37	1	228582770	228582770	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:228582770A>G	uc001hss.2	-	6	1298	c.1043T>C	c.(1042-1044)GTT>GCT	p.V348A	TRIM11_uc010pvx.1_Missense_Mutation_p.V347A	NM_145214	NP_660215	Q96F44	TRI11_HUMAN	tripartite motif-containing 11	348	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			lung(3)|ovary(1)	4		Prostate(94;0.0724)				GCGGTCCCCAACCTCCACCTC	0.697													15	17					0	0	0.000308642	0	0
NUP133	55746	broad.mit.edu	37	1	229606485	229606486	+	Missense_Mutation	DNP	GC	CG	CG			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:229606485_229606486GC>CG	uc001htn.2	-	15	2009_2010	c.1917_1918GC>CG	c.(1915-1920)TTGCTC>TTCGTC	p.639_640LL>FV		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	639_640					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TGCTCACAGAGCAACAGTCGAG	0.48													14	53					0	0	6.4e-05	0	0
CAPN9	10753	broad.mit.edu	37	1	230930959	230930959	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:230930959G>A	uc001htz.1	+	18	2034	c.1921G>A	c.(1921-1923)GAT>AAT	p.D641N	CAPN9_uc009xfg.1_Missense_Mutation_p.D578N|CAPN9_uc001hua.1_Missense_Mutation_p.D615N	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	641	Domain IV.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CAGGTATGCGGATGAGGAGCT	0.612													31	16					0	0	0.0024448	0	0
TTC13	79573	broad.mit.edu	37	1	231044507	231044507	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:231044507C>T	uc001huf.3	-	22	2450	c.2419G>A	c.(2419-2421)GGT>AGT	p.G807S	TTC13_uc009xfi.2_Missense_Mutation_p.G754S|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.G753S|TTC13_uc009xfk.1_Missense_Mutation_p.G696S	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	807							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		GCCTCTGAACCAGGGGCTGTC	0.448													16	32					0	0	0.000958276	0	0
TRIM67	440730	broad.mit.edu	37	1	231333210	231333210	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:231333210C>T	uc009xfn.1	+	2	1180	c.1138C>T	c.(1138-1140)CAG>TAG	p.Q380*		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	380	Potential.					cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GCAGCAGATCCAGGTGAGCAC	0.388													23	48					0	0	0.00047179	0	0
RBM34	23029	broad.mit.edu	37	1	235316029	235316029	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:235316029G>A	uc001hwn.2	-	5	679	c.649C>T	c.(649-651)CGT>TGT	p.R217C	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Missense_Mutation_p.R217C	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	217	RRM 1.					nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			ACCAGAGAACGAAATCGTACA	0.299													43	32					0	0	0.000781405	0	0
GGPS1	9453	broad.mit.edu	37	1	235505825	235505825	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:235505825C>T	uc001hwv.2	+	4	725	c.641C>T	c.(640-642)TCA>TTA	p.S214L	GGPS1_uc001hww.2_Missense_Mutation_p.S214L|GGPS1_uc001hwx.2_Missense_Mutation_p.S160L|GGPS1_uc001hwy.2_Missense_Mutation_p.S214L	NM_001037277	NP_001032354	O95749	GGPPS_HUMAN	geranylgeranyl diphosphate synthase 1 isoform A	214					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	dimethylallyltranstransferase activity|farnesyltranstransferase activity|geranyltranstransferase activity|metal ion binding			central_nervous_system(1)	1	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;1.39e-05)			GGAAAGTTCTCATTTCCTACT	0.368													17	51					0	0	0.00152264	0	0
EDARADD	128178	broad.mit.edu	37	1	236645630	236645630	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:236645630C>T	uc001hxu.1	+	6	394	c.329C>T	c.(328-330)CCC>CTC	p.P110L	EDARADD_uc001hxv.1_Missense_Mutation_p.P100L	NM_145861	NP_665860	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain isoform A	110					cell differentiation|signal transduction	cytoplasm					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTCCGGGCCCCCACCATAAGT	0.478													41	20					0	0	0.00222228	0	0
RYR2	6262	broad.mit.edu	37	1	237972271	237972271	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:237972271G>A	uc001hyl.1	+	100	14489	c.14369G>A	c.(14368-14370)CGA>CAA	p.R4790Q	RYR2_uc010pyb.1_Missense_Mutation_p.R223Q	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4790					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AATTTTTTCCGAAAATTCTAC	0.353													74	192					0	0	0.000781405	0	0
CHRM3	1131	broad.mit.edu	37	1	240071798	240071798	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:240071798C>T	uc001hyp.2	+	5	1826	c.1047C>T	c.(1045-1047)TCC>TCT	p.S349S		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	349	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TGGAGAACTCCGCCTCCTCCG	0.572													9	6					0	0	0.000274275	0	0
FMN2	56776	broad.mit.edu	37	1	240370636	240370636	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:240370636G>A	uc010pyd.1	+	5	2749	c.2524G>A	c.(2524-2526)GAA>AAA	p.E842K	FMN2_uc010pye.1_Missense_Mutation_p.E846K	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	842	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AACCAGCCACGAACACTCTGT	0.557													62	25					0	0	0.000781405	0	0
PLD5	200150	broad.mit.edu	37	1	242271141	242271141	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:242271141C>T	uc001hzn.1	-	8	1198	c.1071G>A	c.(1069-1071)AGG>AGA	p.R357R	PLD5_uc001hzl.3_Silent_p.R295R|PLD5_uc001hzm.3_Silent_p.R147R|PLD5_uc001hzo.1_Silent_p.R265R			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	357						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GCCAGTAAGTCCTGCAGAAAT	0.353													64	42					0	0	0.000781405	0	0
ADSS	159	broad.mit.edu	37	1	244587324	244587324	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:244587324G>A	uc001iaj.2	-	6	806	c.512C>T	c.(511-513)TCG>TTG	p.S171L	ADSS_uc009xgr.1_RNA	NM_001126	NP_001117	P30520	PURA2_HUMAN	adenylosuccinate synthase	171					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(2)|kidney(1)	3	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	AGCTTTGGACGAATAAACTGG	0.423													24	14					0	0	0.000720815	0	0
CNST	163882	broad.mit.edu	37	1	246810669	246810669	+	Missense_Mutation	SNP	C	T	T	rs149528217		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:246810669C>T	uc001ibp.2	+	9	1544	c.1166C>T	c.(1165-1167)TCT>TTT	p.S389F	CNST_uc001ibo.3_Missense_Mutation_p.S389F	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	389					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						GGGCCAGACTCTTCTGAGGAT	0.592											OREG0014367	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	118	55					0	0	0.000781405	0	0
ZNF670	93474	broad.mit.edu	37	1	247201468	247201468	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:247201468G>C	uc001icd.1	-	4	624	c.453C>G	c.(451-453)ATC>ATG	p.I151M	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	151	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			TGGTGAGAGAGATAAAGGCTT	0.403													85	48					0	0	0.000781405	0	0
ZNF496	84838	broad.mit.edu	37	1	247464520	247464520	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:247464520G>A	uc001ico.2	-	9	1530	c.1065C>T	c.(1063-1065)ATC>ATT	p.I355I	ZNF496_uc009xgv.2_Silent_p.I391I|ZNF496_uc001icp.2_Silent_p.I355I	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	355					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			TGGAGAGAACGATCTCGATGG	0.627													18	78					0	0	0.00121646	0	0
NLRP3	114548	broad.mit.edu	37	1	247597405	247597405	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:247597405G>A	uc001icr.2	+	7	2466	c.2328G>A	c.(2326-2328)TGG>TGA	p.W776*	NLRP3_uc001ics.2_Nonsense_Mutation_p.W776*|NLRP3_uc001icu.2_Nonsense_Mutation_p.W776*|NLRP3_uc001icw.2_Silent_p.G719G|NLRP3_uc001icv.2_Silent_p.G719G|NLRP3_uc010pyw.1_Intron	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	776	LRR 2.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGGCATGAAGGTTGGGGCGCT	0.572													113	55					0	0	0.000781405	0	0
OR6F1	343169	broad.mit.edu	37	1	247875297	247875297	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:247875297G>A	uc001idj.1	-	1	761	c.761C>T	c.(760-762)TCC>TTC	p.S254F		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GAAAACTGTGGACCCATACCA	0.537													17	91					0	0	0.000566183	0	0
OR1C1	26188	broad.mit.edu	37	1	247921190	247921190	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:247921190G>A	uc010pza.1	-	1	519	c.519C>T	c.(517-519)ATC>ATT	p.I173I		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	173	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AATGATGGATGATATTGGAGG	0.473													27	14					0	0	0.000720815	0	0
OR2L3	391192	broad.mit.edu	37	1	248224344	248224344	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:248224344C>T	uc001idx.1	+	1	361	c.361C>T	c.(361-363)CGT>TGT	p.R121C	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GGCCTATGATCGTTACATTGC	0.443													95	58					0	0	0.000781405	0	0
OR2M3	127062	broad.mit.edu	37	1	248366863	248366863	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:248366863C>T	uc010pzg.1	+	1	494	c.494C>T	c.(493-495)TCC>TTC	p.S165F		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCAACATTTTCCTTCTCCTAC	0.433													90	61					0	0	0.000781405	0	0
OR2M4	26245	broad.mit.edu	37	1	248402323	248402323	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:248402323C>T	uc010pzh.1	+	1	93	c.93C>T	c.(91-93)GTC>GTT	p.V31V		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTTCTCTGGTCCTGGGCATCT	0.478													43	35					0	0	0.00285205	0	0
GTPBP4	23560	broad.mit.edu	37	10	1054962	1054962	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:1054962C>T	uc001ift.2	+	11	1249	c.1178C>T	c.(1177-1179)TCC>TTC	p.S393F	GTPBP4_uc010qac.1_Missense_Mutation_p.S184F|GTPBP4_uc001ifu.2_RNA|GTPBP4_uc010qad.1_Missense_Mutation_p.S277F|GTPBP4_uc010qae.1_Missense_Mutation_p.S346F	NM_012341	NP_036473	Q9BZE4	NOG1_HUMAN	G protein-binding protein CRFG	393					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		ACTGAGGAGTCCAGGAAGAAG	0.557													34	15					0	0	0.000814825	0	0
ADARB2	105	broad.mit.edu	37	10	1406045	1406045	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:1406045G>A	uc009xhq.2	-	3	629	c.255C>T	c.(253-255)TCC>TCT	p.S85S		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	85					mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		cccggtccccggagggcggtg	0.453													5	8					0	0	0.000602214	0	0
FBXO18	84893	broad.mit.edu	37	10	5979201	5979201	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:5979201C>T	uc001iis.2	+	21	3185	c.3090C>T	c.(3088-3090)ATC>ATT	p.I1030I	FBXO18_uc001iir.2_Silent_p.I973I|FBXO18_uc009xig.2_Silent_p.I956I|FBXO18_uc001iit.2_Silent_p.I1081I	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	1030					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						TGGAGAACATCGTACTGCCCC	0.662													11	3					0	0	0.00136819	0	0
USP6NL	9712	broad.mit.edu	37	10	11505568	11505568	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:11505568G>A	uc001ikt.3	-	15	1680	c.1359C>T	c.(1357-1359)CTC>CTT	p.L453L	USP6NL_uc001iks.1_Silent_p.L470L	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	453						intracellular	Rab GTPase activator activity				0						GACCCGATGGGAGTTTTCTTT	0.507													60	47					0	0	0.000781405	0	0
SEC61A2	55176	broad.mit.edu	37	10	12206337	12206337	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:12206337G>T	uc001ile.2	+	12	1462	c.1315G>T	c.(1315-1317)GGG>TGG	p.G439W	SEC61A2_uc010qbq.1_Missense_Mutation_p.G417W|SEC61A2_uc001ilf.3_Intron|SEC61A2_uc001ilh.3_Intron|SEC61A2_uc001ilg.3_Intron	NM_018144	NP_060614	Q9H9S3	S61A2_HUMAN	Sec61 alpha form 2 isoform a	439	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1		Renal(717;0.228)				TGACTTCCTGGGGGCCATTGG	0.517													10	442					0.00136819	0.00462231	0.00136819	1	0
CAMK1D	57118	broad.mit.edu	37	10	12595225	12595226	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:12595225_12595226GG>TT	uc001ilo.2	+	2	329_330	c.94_95GG>TT	c.(94-96)GGG>TTG	p.G32L	CAMK1D_uc001iln.2_Missense_Mutation_p.G32L	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	32	ATP (By similarity).|Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		TGTTCACAGCGGGGCCTTTTCC	0.465													9	273					0	0	6.4e-05	0	0
PHYH	5264	broad.mit.edu	37	10	13330474	13330474	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:13330474G>A	uc001imf.2	-	6	652	c.564C>T	c.(562-564)CTC>CTT	p.L188L	PHYH_uc001ime.2_Silent_p.L88L|PHYH_uc001img.2_Silent_p.L171L	NM_006214	NP_006205	O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase isoform a precursor	188					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding				0		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	CGCAAACGATGAGATCGCTGG	0.577													40	23					0	0	0.000781405	0	0
SEPHS1	22929	broad.mit.edu	37	10	13380726	13380726	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:13380726G>A	uc001imk.2	-	3	635	c.276C>T	c.(274-276)ATC>ATT	p.I92I	SEPHS1_uc001imh.2_5'Flank|SEPHS1_uc010qbs.1_Silent_p.I44I|SEPHS1_uc001imi.2_Silent_p.I92I|SEPHS1_uc001imj.2_Silent_p.I92I|SEPHS1_uc010qbt.1_Silent_p.I25I|SEPHS1_uc009xje.2_Silent_p.I92I	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	92					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						GGTCGTCTACGATCGGGTAAA	0.463													31	79					0	0	0.00058488	0	0
FAM171A1	221061	broad.mit.edu	37	10	15317887	15317887	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:15317887C>T	uc001iob.2	-	3	392	c.385G>A	c.(385-387)GAA>AAA	p.E129K		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	129	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						ACGACATCTTCATATACCATT	0.303													18	65					0	0	0.00152264	0	0
CUBN	8029	broad.mit.edu	37	10	16967596	16967596	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:16967596C>T	uc001ioo.2	-	42	6501	c.6449G>A	c.(6448-6450)GGG>GAG	p.G2150E		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2150	CUB 15.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAAGTAATCCCCCTGGTTGCA	0.423													8	28					0	0	0.000274275	0	0
PLXDC2	84898	broad.mit.edu	37	10	20500617	20500617	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:20500617C>T	uc001iqg.1	+	10	1718	c.1081C>T	c.(1081-1083)CGT>TGT	p.R361C	PLXDC2_uc001iqh.1_Missense_Mutation_p.R312C|PLXDC2_uc009xkc.1_Intron	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	361	Extracellular (Potential).|PSI.					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TGGATTTGATCGTCATCGGCA	0.438													32	27					0	0	0.00195071	0	0
GPR158	57512	broad.mit.edu	37	10	25887866	25887866	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:25887866G>A	uc001isj.2	+	11	3371	c.3311G>A	c.(3310-3312)GGA>GAA	p.G1104E	GPR158_uc001isk.2_Missense_Mutation_p.G479E	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1104	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GAGGAGAACGGAGGTCAGCCT	0.493													26	68					0	0	0.000720815	0	0
GAD2	2572	broad.mit.edu	37	10	26508071	26508071	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:26508071C>T	uc001isp.2	+	4	889	c.386C>T	c.(385-387)TCA>TTA	p.S129L	GAD2_uc009xkr.2_Missense_Mutation_p.S129L|GAD2_uc001isq.2_Missense_Mutation_p.S129L	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	129					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TTCGATAGATCAACCAAAGTG	0.403													38	117					0	0	0.000953801	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702640	27702640	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:27702640C>T	uc001itu.2	-	1	658	c.540G>A	c.(538-540)GCG>GCA	p.A180A		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	180					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						AGCGCCGCTCCGCCTTGGCCG	0.632													111	57					0	0	0.000781405	0	0
MKX	283078	broad.mit.edu	37	10	28023391	28023391	+	Missense_Mutation	SNP	G	A	A	rs138096382		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:28023391G>A	uc001ity.3	-	5	1057	c.832C>T	c.(832-834)CGC>TGC	p.R278C	MKX_uc001itx.3_Missense_Mutation_p.R278C	NM_173576	NP_775847	Q8IYA7	MKX_HUMAN	mohawk homeobox	278					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTACCTGTGCGATAGACAAAG	0.393													41	22					0	0	0.0025221	0	0
ARMC4	55130	broad.mit.edu	37	10	28272861	28272861	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:28272861G>A	uc009xky.2	-	6	828	c.730C>T	c.(730-732)CGT>TGT	p.R244C	ARMC4_uc010qds.1_5'Flank|ARMC4_uc010qdt.1_5'Flank|ARMC4_uc001itz.2_Missense_Mutation_p.R244C|ARMC4_uc010qdu.1_5'Flank	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	244							binding			ovary(4)|skin(2)	6						ATTTCCCCACGAATTTGTCTC	0.403													27	19					0	0	0.000878237	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315884	30315884	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:30315884C>T	uc001iux.2	-	2	3252	c.3193G>A	c.(3193-3195)GAG>AAG	p.E1065K	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.E927K|KIAA1462_uc009xle.1_Missense_Mutation_p.E1065K	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1065										ovary(4)	4						AAAGACCCCTCTAGCTCACTG	0.592													43	120					0	0	0.000781405	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316043	30316043	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:30316043C>A	uc001iux.2	-	2	3093	c.3034G>T	c.(3034-3036)GTG>TTG	p.V1012L	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.V874L|KIAA1462_uc009xle.1_Missense_Mutation_p.V1012L	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1012										ovary(4)	4						CTTGGTTTCACAGAGCTGAAA	0.562													73	49					9.42754e-34	3.25309e-33	0.000781405	1	0
LYZL2	119180	broad.mit.edu	37	10	30901757	30901757	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:30901757T>A	uc001ivk.2	-	4	522	c.509A>T	c.(508-510)AAC>ATC	p.N170I		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	124					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				TTACCAATAGTTCATTCCTTG	0.423													12	38					0	0	0.00185496	0	0
Unknown	0	broad.mit.edu	37	10	30998345	30998345	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:30998345C>T	uc010qdx.1	+	8	1433	c.891C>T	c.(889-891)CCC>CCT	p.P297P						SubName: Full=cDNA FLJ59642, highly similar to Supervillin;																		GTTCCATGCCCTTCCTGCAGG	0.612													26	18					0	0	0.00178596	0	0
CCNY	219771	broad.mit.edu	37	10	35857996	35857996	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:35857996C>T	uc001iyw.3	+	10	1104	c.924C>T	c.(922-924)CTC>CTT	p.L308L	CCNY_uc001iyu.3_Silent_p.L254L|CCNY_uc001iyv.3_Silent_p.L254L|CCNY_uc001iyx.3_Silent_p.L254L|CCNY_uc009xmb.2_Silent_p.L283L|CCNY_uc010qet.1_Silent_p.L175L	NM_145012	NP_659449	Q8ND76	CCNY_HUMAN	cyclin Y isoform 1	308					cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding				0						TCTCTCGCCTCTGCGAGGACA	0.612													21	13					0	0	0.00121646	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37441020	37441020	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:37441020G>A	uc001iza.1	+	12	1609	c.1510G>A	c.(1510-1512)GAC>AAC	p.D504N		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	560						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CAAACAAAAGGACTATGAAGA	0.299													14	58					0	0	0.000422831	0	0
LOC100133308	100133308	broad.mit.edu	37	10	45602574	45602574	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:45602574C>T	uc001jby.2	-	1		c.863G>A			LOC100133308_uc001jbz.2_Intron|LOC100133308_uc009xmq.1_Intron					Homo sapiens cDNA FLJ32851 fis, clone TESTI2003432.												0						GGCATGGAACCCAACCATTTG	0.433													6	7					0	0	0.00116845	0	0
ZNF488	118738	broad.mit.edu	37	10	48371305	48371305	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:48371305C>T	uc001jex.2	+	2	935	c.773C>T	c.(772-774)TCG>TTG	p.S258L	ZNF488_uc001jey.2_Missense_Mutation_p.S151L	NM_153034	NP_694579	Q96MN9	ZN488_HUMAN	zinc finger protein 488	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCCACCACTTCGTGGGCCCTC	0.612													34	19					0	0	0.00283554	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49667799	49667799	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:49667799A>T	uc001jgt.2	-	5	884	c.587T>A	c.(586-588)ATG>AAG	p.M196K	ARHGAP22_uc001jgs.2_Missense_Mutation_p.M106K|ARHGAP22_uc001jgu.2_Missense_Mutation_p.M212K|ARHGAP22_uc010qgl.1_Missense_Mutation_p.M153K|ARHGAP22_uc010qgm.1_Missense_Mutation_p.M202K|ARHGAP22_uc001jgv.2_5'UTR	NM_021226	NP_067049	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 2	196	Rho-GAP.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			ovary(1)	1						CTGGCCTGGCATGCGGAACAG	0.642													65	44					0	0	0.000781405	0	0
LRRC18	474354	broad.mit.edu	37	10	50121768	50121768	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:50121768C>T	uc001jhd.2	-	1	513	c.433G>A	c.(433-435)GAG>AAG	p.E145K	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.E145K	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	145	LRR 6.					cytoplasm				ovary(1)|pancreas(1)	2						TCGTGGAGCTCCTTCAGGGCC	0.582													7	22					0	0	0.00198382	0	0
OGDHL	55753	broad.mit.edu	37	10	50952113	50952113	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:50952113G>A	uc001jie.2	-	14	1930	c.1788C>T	c.(1786-1788)ATC>ATT	p.I596I	OGDHL_uc009xog.2_Silent_p.I623I|OGDHL_uc010qgt.1_Silent_p.I539I|OGDHL_uc010qgu.1_Silent_p.I387I|OGDHL_uc009xoh.2_Silent_p.I387I	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	596					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						TGTCCTCAGGGATCCCCGTGG	0.597													25	15					0	0	0.000586117	0	0
CSTF2T	23283	broad.mit.edu	37	10	53458235	53458236	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:53458235_53458236GG>AA	uc001jjp.2	-	1	1120_1121	c.1074_1075CC>TT	c.(1072-1077)CCCCAT>CCTTAT	p.H359Y	PRKG1_uc001jjm.2_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.2_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit	359	Gly-rich.				mRNA processing	nucleus	nucleotide binding|RNA binding			ovary(1)	1				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GGACCCTGATGGGGTGGACCCA	0.559													36	29					0	0	6.4e-05	0	0
MBL2	4153	broad.mit.edu	37	10	54531369	54531369	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:54531369G>A	uc001jjt.2	-	1	92	c.27C>T	c.(25-27)CTC>CTT	p.L9L		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	9					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						TCAGGAGAAGGAGAGGGAGTG	0.502													14	13					0	0	0.000308642	0	0
PCDH15	65217	broad.mit.edu	37	10	55591294	55591294	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:55591294C>T	uc001jju.1	-	30	4379	c.3984_splice	c.e30-1	p.K1328_splice	PCDH15_uc010qhq.1_Splice_Site_p.K1333_splice|PCDH15_uc010qhr.1_Splice_Site_p.K1328_splice|PCDH15_uc010qhs.1_Splice_Site_p.K1340_splice|PCDH15_uc010qht.1_Splice_Site_p.K1335_splice|PCDH15_uc010qhu.1_Splice_Site_p.K1328_splice|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Splice_Site_p.K1328_splice|PCDH15_uc010qhw.1_Splice_Site_p.K1291_splice|PCDH15_uc010qhx.1_Splice_Site_p.K1257_splice|PCDH15_uc010qhy.1_Splice_Site_p.K1333_splice|PCDH15_uc010qhz.1_Splice_Site_p.K1328_splice|PCDH15_uc010qia.1_Splice_Site_p.K1306_splice|PCDH15_uc010qib.1_Splice_Site_p.K1306_splice	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor						equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ATCCAAAAATCTTTATTGTTA	0.338										HNSCC(58;0.16)			20	10					0	0	0.00188189	0	0
PCDH15	65217	broad.mit.edu	37	10	55700729	55700729	+	Silent	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:55700729A>C	uc001jju.1	-	24	3524	c.3129T>G	c.(3127-3129)CCT>CCG	p.P1043P	PCDH15_uc010qhq.1_Silent_p.P1048P|PCDH15_uc010qhr.1_Silent_p.P1043P|PCDH15_uc010qhs.1_Silent_p.P1055P|PCDH15_uc010qht.1_Silent_p.P1050P|PCDH15_uc010qhu.1_Silent_p.P1043P|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Silent_p.P1043P|PCDH15_uc010qhw.1_Silent_p.P1006P|PCDH15_uc010qhx.1_Silent_p.P972P|PCDH15_uc010qhy.1_Silent_p.P1048P|PCDH15_uc010qhz.1_Silent_p.P1043P|PCDH15_uc010qia.1_Silent_p.P1021P|PCDH15_uc010qib.1_Silent_p.P1021P	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1043	Cadherin 10.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CACTTACTGGAGGAGGTCTGC	0.279										HNSCC(58;0.16)			35	21					0	0	0.000953801	0	0
STOX1	219736	broad.mit.edu	37	10	70645751	70645751	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:70645751T>C	uc001jos.2	+	3	2286	c.2199T>C	c.(2197-2199)AGT>AGC	p.S733S	STOX1_uc001jor.2_Intron|STOX1_uc009xpy.2_Intron|STOX1_uc001joq.2_Silent_p.S623S	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	733						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						GTGCCTGTAGTTCATTATATC	0.453													43	39					0	0	0.00285205	0	0
COL13A1	1305	broad.mit.edu	37	10	71707091	71707091	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:71707091G>A	uc001jpr.1	+	36	2554	c.2018G>A	c.(2017-2019)GGA>GAA	p.G673E	COL13A1_uc001jqj.1_Missense_Mutation_p.G646E|COL13A1_uc001jps.1_Missense_Mutation_p.G644E|COL13A1_uc001jpt.1_Missense_Mutation_p.G632E|COL13A1_uc001jpu.1_Missense_Mutation_p.G642E|COL13A1_uc001jpv.1_Missense_Mutation_p.G647E|COL13A1_uc001jpx.1_Missense_Mutation_p.G624E|COL13A1_uc001jpw.1_Missense_Mutation_p.G620E|COL13A1_uc001jpy.1_Missense_Mutation_p.G611E|COL13A1_uc001jpz.1_Missense_Mutation_p.G616E|COL13A1_uc001jqa.1_Missense_Mutation_p.G613E|COL13A1_uc001jqc.1_Missense_Mutation_p.G658E|COL13A1_uc001jqb.1_Missense_Mutation_p.G595E|COL13A1_uc001jql.2_Missense_Mutation_p.G673E|COL13A1_uc001jqd.1_Missense_Mutation_p.G661E|COL13A1_uc001jqe.1_Missense_Mutation_p.G656E|COL13A1_uc001jqf.1_Missense_Mutation_p.G654E|COL13A1_uc001jqg.1_Missense_Mutation_p.G651E|COL13A1_uc001jqh.1_Missense_Mutation_p.G661E|COL13A1_uc001jqi.1_Missense_Mutation_p.G659E|COL13A1_uc010qjf.1_Missense_Mutation_p.G448E	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	673	Extracellular (Potential).|Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	GGGGACAAGGGAAACCGGGTG	0.517													13	2					0	0	0.000422831	0	0
KIAA1274	27143	broad.mit.edu	37	10	72298087	72298087	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:72298087G>A	uc001jrd.3	+	12	1656	c.1375G>A	c.(1375-1377)GAG>AAG	p.E459K	KIAA1274_uc001jre.3_5'Flank	NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	459										ovary(2)|central_nervous_system(1)	3						TGCCCACCCTGAGCTGTACCG	0.657													21	5					0	0	0.000878237	0	0
FAM190B	54462	broad.mit.edu	37	10	86131800	86131800	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:86131800C>T	uc001kdh.1	+	2	1186	c.992C>T	c.(991-993)TCT>TTT	p.S331F	FAM190B_uc001kdg.1_Missense_Mutation_p.S331F|FAM190B_uc010qmd.1_Missense_Mutation_p.S331F	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	331										ovary(3)|skin(1)	4						TCTCCATTTTCTGGGACTATG	0.418													57	11					0	0	0.000781405	0	0
IDE	3416	broad.mit.edu	37	10	94268591	94268591	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:94268591G>A	uc001kia.2	-	7	1030	c.954C>T	c.(952-954)CCC>CCT	p.P318P		NM_004969	NP_004960	P14735	IDE_HUMAN	insulin-degrading enzyme isoform 1 precursor	318					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGTCAGGTATGGGAAATGTCA	0.368													299	63					0	0	0.000781405	0	0
PDE6C	5146	broad.mit.edu	37	10	95380655	95380655	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:95380655C>T	uc001kiu.3	+	3	779	c.641C>T	c.(640-642)TCC>TTC	p.S214F		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	214	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TAGGTCTTTTCCAAATACCTC	0.408													238	36					0	0	0.000781405	0	0
CYP2C9	1559	broad.mit.edu	37	10	96731876	96731876	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:96731876C>T	uc001kka.3	+	6	860	c.835C>T	c.(835-837)CCA>TCA	p.P279S	CYP2C9_uc009xut.2_Missense_Mutation_p.P277S	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	279					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GCACAACCAACCATCTGAATT	0.363													47	12					0	0	0.000781405	0	0
SORBS1	10580	broad.mit.edu	37	10	97111052	97111052	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:97111052G>A	uc001kkp.2	-	23	2341	c.2296C>T	c.(2296-2298)CCG>TCG	p.P766S	SORBS1_uc001kkk.2_Missense_Mutation_p.P260S|SORBS1_uc001kkl.2_Missense_Mutation_p.P368S|SORBS1_uc001kkn.2_Missense_Mutation_p.P531S|SORBS1_uc001kkm.2_Missense_Mutation_p.P566S|SORBS1_uc001kko.2_Missense_Mutation_p.P788S|SORBS1_uc001kkq.2_Missense_Mutation_p.P617S|SORBS1_uc001kkr.2_Missense_Mutation_p.P472S|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Missense_Mutation_p.P513S|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.P720S|SORBS1_uc010qoe.1_Missense_Mutation_p.P481S|SORBS1_uc010qof.1_Missense_Mutation_p.P834S	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	766					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		TGGTGCGTCGGAATGACGCCT	0.468													43	7					0	0	0.000680045	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97397094	97397094	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:97397094G>A	uc001kkz.2	-	4	645	c.403C>T	c.(403-405)CAG>TAG	p.Q135*	ALDH18A1_uc001kky.2_Nonsense_Mutation_p.Q135*|ALDH18A1_uc010qog.1_Nonsense_Mutation_p.Q24*|ALDH18A1_uc010qoh.1_Intron	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	135	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	CGCACGCTCTGAGACAGAAGG	0.552													6	46					0	0	0.00198382	0	0
CRTAC1	55118	broad.mit.edu	37	10	99771025	99771025	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:99771025C>A	uc001kou.1	-	2	450	c.94G>T	c.(94-96)GAA>TAA	p.E32*	CRTAC1_uc001kov.2_Nonsense_Mutation_p.E21*	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	32						proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		AACATGGGTTCAGCCCGCTGG	0.512													37	41					6.70999e-13	2.2967e-12	0.000814825	1	0
DNMBP	23268	broad.mit.edu	37	10	101715157	101715158	+	Missense_Mutation	DNP	GG	AA	AA	rs148247428		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:101715157_101715158GG>AA	uc001kqj.2	-	4	2165_2166	c.2073_2074CC>TT	c.(2071-2076)TGCCCC>TGTTCC	p.P692S	NCRNA00093_uc001kqk.1_Intron	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	692					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		AGCACTAAGGGGCATGGGGAGG	0.53													23	0					0	0	6.4e-05	0	0
CPN1	1369	broad.mit.edu	37	10	101835787	101835787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:101835787C>T	uc001kql.2	-	2	561	c.301G>A	c.(301-303)GAG>AAG	p.E101K		NM_001308	NP_001299	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1 precursor	101	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(3)|pancreas(1)	4		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		CACAGAAACTCCGACAGCTGC	0.577													40	14					0	0	0.00195071	0	0
SFXN3	81855	broad.mit.edu	37	10	102799263	102799263	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:102799263A>G	uc001ksp.2	+	12	1355	c.899A>G	c.(898-900)AAC>AGC	p.N300S	SFXN3_uc001ksq.2_Missense_Mutation_p.N300S|SFXN3_uc010qpx.1_Missense_Mutation_p.N304S	NM_030971	NP_112233	Q9BWM7	SFXN3_HUMAN	sideroflexin 3	300					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CACATAAGCAACCTGGAACCA	0.557													68	15					0	0	0.000781405	0	0
ITPRIP	85450	broad.mit.edu	37	10	106074292	106074292	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:106074292G>A	uc001kye.2	-	2	1591	c.1518C>T	c.(1516-1518)TTC>TTT	p.F506F	ITPRIP_uc001kyf.2_Silent_p.F506F|ITPRIP_uc001kyg.2_Silent_p.F506F	NM_033397	NP_203755	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-triphosphate receptor interacting	506						plasma membrane					0						GCTGCAGGACGAAGGGCCGGA	0.587													37	9					0	0	0.00148497	0	0
SORCS3	22986	broad.mit.edu	37	10	106937871	106937871	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:106937871C>T	uc001kyi.1	+	14	2176	c.1949C>T	c.(1948-1950)TCG>TTG	p.S650L	SORCS3_uc010qqz.1_Intron	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	650	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGTTTCACTTCGGTTCCTCTC	0.473													43	8					0	0	0.000781405	0	0
NRAP	4892	broad.mit.edu	37	10	115374691	115374691	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:115374691T>C	uc001laj.2	-	28	3257	c.3093A>G	c.(3091-3093)GAA>GAG	p.E1031E	NRAP_uc009xyb.2_Intron|NRAP_uc001lak.2_Silent_p.E996E|NRAP_uc001lal.3_Silent_p.E1031E	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1031	Nebulin 26.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TGCTCCAGGATTCCTTATAAC	0.458													39	6					0	0	0.0025221	0	0
VWA2	340706	broad.mit.edu	37	10	116049157	116049157	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:116049157G>A	uc001lbl.1	+	12	2352	c.2031G>A	c.(2029-2031)AGG>AGA	p.R677R	VWA2_uc001lbk.1_Silent_p.R677R|VWA2_uc009xyf.1_Silent_p.R373R	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	677	VWFA 3.					extracellular region				ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5				Epithelial(162;0.036)|all cancers(201;0.0793)		GTCTGCGGAGGCTTGCAGGTC	0.627													31	4					0	0	0.000814825	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116067573	116067573	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:116067573C>T	uc001lbn.2	-	10	1364	c.1063G>A	c.(1063-1065)GAG>AAG	p.E355K	AFAP1L2_uc001lbo.2_Missense_Mutation_p.E355K|AFAP1L2_uc010qse.1_Missense_Mutation_p.E408K|AFAP1L2_uc001lbp.2_Missense_Mutation_p.E383K|AFAP1L2_uc001lbr.1_Missense_Mutation_p.E355K|AFAP1L2_uc010qsd.1_5'Flank	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	355	PH 2.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		CTGGATGTCTCGAGGGACCTC	0.413													28	8					0	0	0.0024448	0	0
SLC18A2	6571	broad.mit.edu	37	10	119013971	119013971	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:119013971G>A	uc001ldd.1	+	6	694	c.663G>A	c.(661-663)ATG>ATA	p.M221I	SLC18A2_uc009xyy.1_Missense_Mutation_p.M18I	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	221	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	GCAACGTCATGGGAATCGCCT	0.592													29	6					0	0	0.00170553	0	0
CPXM2	119587	broad.mit.edu	37	10	125521433	125521433	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:125521433C>T	uc001lhk.1	-	11	2057	c.1732G>A	c.(1732-1734)GAG>AAG	p.E578K	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	578					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GTGCCCTCCTCCTTCTGGAAG	0.667													17	0					0	0	0.000958276	0	0
C10orf90	118611	broad.mit.edu	37	10	128114453	128114454	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:128114453_128114454GG>AA	uc001ljq.2	-	9	2200_2201	c.2079_2080CC>TT	c.(2077-2082)CTCCTT>CTTTTT	p.L694F	C10orf90_uc001ljp.2_Missense_Mutation_p.L550F|C10orf90_uc010qum.1_Missense_Mutation_p.L791F|C10orf90_uc001ljo.2_RNA	NM_001004298	NP_001004298	Q96M02	CJ090_HUMAN	hypothetical protein LOC118611	694										ovary(1)|skin(1)	2		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TTCCTTTGAAGGAGCTGGTCCA	0.5													17	2					0	0	6.4e-05	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133948557	133948557	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:133948557G>A	uc001lkx.3	+	4	862	c.862G>A	c.(862-864)GAT>AAT	p.D288N		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		ACAGCAGTTGGATGAAAAAGA	0.483													29	5					0	0	0.00178596	0	0
JAKMIP3	282973	broad.mit.edu	37	10	133954054	133954054	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:133954054C>T	uc001lkx.3	+	9	1444	c.1444C>T	c.(1444-1446)CCG>TCG	p.P482S		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GGACCAGACCCCGTGCACCCC	0.622													11	1					0	0	0.000978159	0	0
GPR123	84435	broad.mit.edu	37	10	134896174	134896174	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:134896174G>A	uc001llw.2	+	6	1260	c.1260G>A	c.(1258-1260)CTG>CTA	p.L420L				Q86SQ6	GP123_HUMAN	RecName: Full=Probable G-protein coupled receptor 123;	Error:Variant_position_missing_in_Q86SQ6_after_alignment						integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GCCTTGGCCTGAGGTGGGCAT	0.622													16	4					0	0	0.00074312	0	0
GPR123	84435	broad.mit.edu	37	10	134942980	134942980	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:134942980C>T	uc001llx.3	+	7	2084	c.1648C>T	c.(1648-1650)CGA>TGA	p.R550*	GPR123_uc001llw.2_Nonsense_Mutation_p.R1269*	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	550	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CGGCAACATCCGAACGGGACC	0.612													12	1					0	0	0.00244969	0	0
CYP2E1	1571	broad.mit.edu	37	10	135350625	135350625	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:135350625G>A	uc001lnj.1	+	7	1059	c.1026G>A	c.(1024-1026)AAG>AAA	p.K342K	CYP2E1_uc001lnk.1_Silent_p.K205K|CYP2E1_uc009ybl.1_Silent_p.K143K|CYP2E1_uc009ybm.1_5'UTR|CYP2E1_uc001lnl.1_Silent_p.K143K	NM_000773	NP_000764	P05181	CP2E1_HUMAN	cytochrome P450, family 2, subfamily E,	342					drug metabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding			central_nervous_system(3)	3		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)	Acetaminophen(DB00316)|Chlorzoxazone(DB00356)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Dacarbazine(DB00851)|Dapsone(DB00250)|Enflurane(DB00228)|Eszopiclone(DB00402)|Ethanol(DB00898)|Ethosuximide(DB00593)|Fomepizole(DB01213)|Glutathione(DB00143)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Isoniazid(DB00951)|Menadione(DB00170)|Mephenytoin(DB00532)|Methoxyflurane(DB01028)|Midazolam(DB00683)|Mitoxantrone(DB01204)|Nicotine(DB00184)|Nifedipine(DB01115)|Nitrofurantoin(DB00698)|Orphenadrine(DB01173)|Phenelzine(DB00780)|Quinidine(DB00908)|S-Adenosylmethionine(DB00118)|Sevoflurane(DB01236)|Theophylline(DB00277)|Tolbutamide(DB01124)	CTGCCATCAAGGATAGGCAAG	0.517									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				35	47					0	0	0.000953801	0	0
IRF7	3665	broad.mit.edu	37	11	615225	615225	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:615225G>A	uc001lqh.2	-	3	425	c.55C>T	c.(55-57)CTT>TTT	p.L19F	IRF7_uc009ycb.2_5'UTR|IRF7_uc010qwf.1_Missense_Mutation_p.L19F|IRF7_uc001lqf.2_5'UTR|IRF7_uc010qwg.1_5'UTR|IRF7_uc001lqg.2_Missense_Mutation_p.L32F|IRF7_uc001lqi.2_Missense_Mutation_p.L19F|IRF7_uc010qwh.1_5'UTR	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	19	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCTCTCCAAGGAGCCACTCT	0.697													6	6					0	0	0.00198382	0	0
LRDD	55367	broad.mit.edu	37	11	804258	804258	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:804258G>A	uc001lro.1	-	2	273	c.131C>T	c.(130-132)CCC>CTC	p.P44L	LRDD_uc009yck.1_5'Flank|LRDD_uc001lrk.1_Missense_Mutation_p.P44L|LRDD_uc001lrl.1_5'UTR|LRDD_uc001lrm.1_5'UTR|LRDD_uc001lrn.1_5'UTR|LRDD_uc001lrp.1_5'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	44					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCAGCCCCCGGGGTACAGGTC	0.652													4	13					0	0	0.000602214	0	0
MUC5B	727897	broad.mit.edu	37	11	1271018	1271018	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:1271018G>A	uc009ycr.1	+	51	14453	c.14327G>A	c.(14326-14328)AGG>AAG	p.R4776K	MUC5B_uc001ltb.2_Missense_Mutation_p.R4306K	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4303	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCCAGTCCAAGGACTGCAACC	0.627													40	55					0	0	0.00170553	0	0
MUC5B	727897	broad.mit.edu	37	11	1272721	1272721	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:1272721C>T	uc009ycr.1	+	52	15703	c.15577C>T	c.(15577-15579)CTG>TTG	p.L5193L	MUC5B_uc001ltb.2_Silent_p.L4874L	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4871	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTCCTCCACTCTGGGAACAGC	0.657													11	13					0	0	0.000978159	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1642816	1642816	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:1642816A>C	uc009ycy.1	-	4	733	c.646T>G	c.(646-648)TGT>GGT	p.C216G		NM_001012709	NP_001012727	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	230	9 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GATGACCCACAACCTGAGGAG	0.612													36	56					0	0	0.00111076	0	0
SYT8	90019	broad.mit.edu	37	11	1858493	1858493	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:1858493C>T	uc001lue.1	+	9	1166	c.1038C>T	c.(1036-1038)CAC>CAT	p.H346H	SYT8_uc001lud.2_Silent_p.H346H|SYT8_uc001luf.1_Silent_p.H332H|TNNI2_uc010qxc.1_5'Flank|TNNI2_uc010qxd.1_5'Flank|TNNI2_uc010qxe.1_5'Flank	NM_138567	NP_612634	Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	346	C2 2.|Cytoplasmic (Potential).					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCAAGGTGCACCTGGGTGCCC	0.706													11	6					0	0	0.000978159	0	0
TRPM5	29850	broad.mit.edu	37	11	2436006	2436006	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:2436006C>T	uc001lwm.3	-	11	1692	c.1683G>A	c.(1681-1683)CTG>CTA	p.L561L	TRPM5_uc010qxl.1_Silent_p.L561L|TRPM5_uc009ydn.2_Silent_p.L563L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	561	Cytoplasmic (Potential).|Potential.					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCTCCGTCTCCAGGTGCGACA	0.572													44	77					0	0	0.000781405	0	0
ART1	417	broad.mit.edu	37	11	3685408	3685408	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:3685408G>A	uc001lye.1	+	5	1074	c.973G>A	c.(973-975)GGC>AGC	p.G325S		NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	325					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	AGATGGTCCAGGCCTCCTTTG	0.577													41	56					0	0	0.000781405	0	0
OR52K2	119774	broad.mit.edu	37	11	4471211	4471211	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:4471211C>T	uc001lyz.1	+	1	642	c.642C>T	c.(640-642)CTC>CTT	p.L214L		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGACCTGCTCCTTGTTATCC	0.488													28	78					0	0	0.0024448	0	0
OR52K1	390036	broad.mit.edu	37	11	4510609	4510609	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:4510609C>T	uc001lza.1	+	1	479	c.479C>T	c.(478-480)CCA>CTA	p.P160L		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CTAATGACTCCACTCCCCTTC	0.587													20	24					0	0	0.00152264	0	0
OR51E2	81285	broad.mit.edu	37	11	4703277	4703277	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:4703277C>T	uc001lzk.2	-	2	909	c.665G>A	c.(664-666)CGA>CAA	p.R222Q		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CAGAACCGTTCGTATTATCAG	0.488													18	26					0	0	0.00121646	0	0
OR51S1	119692	broad.mit.edu	37	11	4869782	4869782	+	Silent	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:4869782C>A	uc010qyo.1	-	1	657	c.657G>T	c.(655-657)CTG>CTT	p.L219L		NM_001004758	NP_001004758	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGAAAATAAGCAGGGGGTCCA	0.542													26	27					0.00047179	0.0015959	0.00047179	1	0
MMP26	56547	broad.mit.edu	37	11	5012667	5012667	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:5012667C>T	uc001lzv.2	+	4	554	c.536C>T	c.(535-537)TCT>TTT	p.S179F		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	179					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		TTACCAAATTCTGGAAATCCT	0.478													34	56					0	0	0.00209593	0	0
OR52A1	23538	broad.mit.edu	37	11	5173450	5173450	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:5173450G>A	uc010qyy.1	-	1	150	c.150C>T	c.(148-150)ATC>ATT	p.I50I		NM_012375	NP_036507	Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGATTTGATGATGCTCAGAA	0.463													19	24					0	0	0.00188189	0	0
OR51B4	79339	broad.mit.edu	37	11	5322332	5322332	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:5322332G>A	uc010qza.1	-	1	845	c.845C>T	c.(844-846)CCA>CTA	p.P282L	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTCACGAATGGAGGAAAGAG	0.433													19	23					0	0	0.000958276	0	0
OR52N1	79473	broad.mit.edu	37	11	5809841	5809841	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:5809841G>A	uc010qzo.1	-	1	206	c.206C>T	c.(205-207)TCC>TTC	p.S69F	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	69	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		ATCTGTGAAGGAAAGAAGGGC	0.458													29	38					0	0	0.000878237	0	0
OR56B4	196335	broad.mit.edu	37	11	6129374	6129374	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:6129374C>T	uc010qzx.1	+	1	366	c.366C>T	c.(364-366)CTC>CTT	p.L122L		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	122	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCATCTTTCTCTGCATGGCAG	0.483													31	40					0	0	0.00058488	0	0
CNGA4	1262	broad.mit.edu	37	11	6261637	6261637	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:6261637G>A	uc001mco.2	+	4	720	c.613G>A	c.(613-615)GAC>AAC	p.D205N	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.D165N	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	205	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTGTACCCGGACCCCGCGCA	0.577													36	46					0	0	0.000953801	0	0
NLRP14	338323	broad.mit.edu	37	11	7063772	7063772	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:7063772C>T	uc001mfb.1	+	4	838	c.515C>T	c.(514-516)ACC>ATC	p.T172I		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	172					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		GATGTCAAAACCGGTGCACAG	0.478													23	24					0	0	0.00278032	0	0
NLRP10	338322	broad.mit.edu	37	11	7981867	7981867	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:7981867G>A	uc001mfv.1	-	2	1309	c.1292C>T	c.(1291-1293)GCT>GTT	p.A431V		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	431	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCTGAGCTCAGCTTCTTCAAA	0.527													30	38					0	0	0.00283554	0	0
RIC3	79608	broad.mit.edu	37	11	8132302	8132302	+	Silent	SNP	G	A	A	rs17852022	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:8132302G>A	uc001mgd.2	-	6	1107	c.1053C>T	c.(1051-1053)ACC>ACT	p.T351T	RIC3_uc001mgb.2_Silent_p.T189T|RIC3_uc001mgc.2_Silent_p.T350T|RIC3_uc001mge.2_Silent_p.T169T|RIC3_uc010rbl.1_Silent_p.T301T|RIC3_uc010rbm.1_Silent_p.T379T|RIC3_uc009yfm.2_Silent_p.T270T|RIC3_uc009yfn.2_Silent_p.T154T	NM_024557	NP_078833	Q7Z5B4	RIC3_HUMAN	resistance to inhibitors of cholinesterase 3	351	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				large_intestine(1)|ovary(1)|pancreas(1)	3				Epithelial(150;2.89e-07)|BRCA - Breast invasive adenocarcinoma(625;0.204)		ATGCTTTATCGGTGCTGATGC	0.478													34	51					0	0	0.000814825	0	0
IPO7	10527	broad.mit.edu	37	11	9459706	9459706	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:9459706G>A	uc001mho.2	+	22	2711	c.2569G>A	c.(2569-2571)GTT>ATT	p.V857I		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	857					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TTTAAATCAGGTTTCTGGACA	0.343													67	73					0	0	0.000781405	0	0
MICALCL	84953	broad.mit.edu	37	11	12315811	12315811	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:12315811G>A	uc001mkg.1	+	3	1124	c.833G>A	c.(832-834)CGA>CAA	p.R278Q		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	278					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		AATGCCATCCGAAGGTCTCTA	0.607													34	21					0	0	0.00283554	0	0
PSMA1	5682	broad.mit.edu	37	11	14526784	14526784	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:14526784G>A	uc001mlk.2	-	10	892	c.746C>T	c.(745-747)CCT>CTT	p.P249L	PSMA1_uc001mll.2_Missense_Mutation_p.P255L|PSMA1_uc010rcp.1_RNA|PSMA1_uc001mlj.2_Missense_Mutation_p.P224L	NM_002786	NP_002777	P25786	PSA1_HUMAN	proteasome alpha 1 subunit isoform 2	249					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			upper_aerodigestive_tract(1)|skin(1)	2						TTCATCAGCAGGTTGAGCAGG	0.323													42	103					0	0	0.000781405	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16812687	16812687	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:16812687G>A	uc001mmo.2	-	20	2820	c.2805C>T	c.(2803-2805)CCC>CCT	p.P935P	PLEKHA7_uc010rcu.1_Silent_p.P936P|PLEKHA7_uc001mmm.2_Silent_p.P38P|PLEKHA7_uc010rcv.1_Silent_p.P510P|PLEKHA7_uc001mmn.2_Silent_p.P644P	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	935	Pro-rich.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						GCACAGCCGGGGGCTGGTCCT	0.642													14	32					0	0	0.00074312	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838358	16838358	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:16838358G>A	uc001mmo.2	-	11	1870	c.1855C>T	c.(1855-1857)CAC>TAC	p.H619Y	PLEKHA7_uc010rcu.1_Missense_Mutation_p.H619Y|PLEKHA7_uc010rcv.1_Missense_Mutation_p.H193Y|PLEKHA7_uc001mmn.2_Missense_Mutation_p.H327Y	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	619	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TTGACAGCGTGGCCCCGTGCC	0.597													19	43					0	0	0.00121646	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17143761	17143761	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:17143761A>G	uc001mmq.3	-	14	2697	c.2631T>C	c.(2629-2631)GAT>GAC	p.D877D	PIK3C2A_uc009ygu.1_Intron|PIK3C2A_uc010rcw.1_Silent_p.D497D|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	877					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	TATGAAGAATATCAAGAAGTT	0.308													28	64					0	0	0.001512	0	0
ABCC8	6833	broad.mit.edu	37	11	17470167	17470168	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:17470167_17470168CC>AA	uc001mnc.2	-	8	1353_1354	c.1227_1228GG>TT	c.(1225-1230)ATGGGA>ATTTGA	p.409_410MG>I*	ABCC8_uc010rcy.1_Nonsense_Mutation_p.408_409MG>I*	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	409_410	Cytoplasmic (By similarity).|ABC transmembrane type-1 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GTCATTTCTCCCATGGACAGGT	0.436													12	489					0	0	6.4e-05	0	0
USH1C	10083	broad.mit.edu	37	11	17523497	17523497	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:17523497G>A	uc001mnf.2	-	16	1424	c.1315C>T	c.(1315-1317)CCC>TCC	p.P439S	USH1C_uc001mne.2_Missense_Mutation_p.P739S|USH1C_uc009yhb.2_Missense_Mutation_p.P420S|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.P403S	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	439					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						ATAGAGTAGGGGTCAAAGCCT	0.542													7	24					0	0	0.000157383	0	0
TPH1	7166	broad.mit.edu	37	11	18062275	18062275	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:18062275G>A	uc001mnp.2	-	1	61	c.35C>T	c.(34-36)TCC>TTC	p.S12F	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	12					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	CCTTTCTAAGGAATGGTCTTT	0.333													8	35					0	0	0.000157383	0	0
LDHC	3948	broad.mit.edu	37	11	18472617	18472617	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:18472617C>T	uc001mon.3	+	8	1054	c.942C>T	c.(940-942)GCC>GCT	p.A314A	LDHC_uc001mom.3_Silent_p.A314A|LDHC_uc009yhp.2_3'UTR|LDHC_uc001moo.3_Silent_p.A198A|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_3'UTR	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	314					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	AGGAGGAGGCCCTTTTCAAGA	0.368													57	44					0	0	0.000781405	0	0
UEVLD	55293	broad.mit.edu	37	11	18596940	18596940	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:18596940C>T	uc001mot.2	-	3	227	c.147G>A	c.(145-147)CAG>CAA	p.Q49Q	UEVLD_uc001mou.2_Silent_p.Q49Q|UEVLD_uc010rde.1_5'UTR|UEVLD_uc010rdf.1_Intron|UEVLD_uc010rdg.1_5'UTR|UEVLD_uc001mov.2_Intron|UEVLD_uc010rdh.1_Silent_p.Q49Q	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	49	UEV.				cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						GCAGGTCTTTCTGAGAACTAT	0.338													58	41					0	0	0.000781405	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18633904	18633904	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:18633904T>G	uc001moy.2	-	4	2059	c.1843A>C	c.(1843-1845)ATA>CTA	p.I615L	SPTY2D1_uc010rdi.1_Missense_Mutation_p.I615L	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	615										breast(1)	1						TGCTTGGATATTTCTTCCTGA	0.338													51	34					0	0	0.000781405	0	0
PTPN5	84867	broad.mit.edu	37	11	18759452	18759452	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:18759452C>T	uc001mpd.2	-	9	1406	c.975G>A	c.(973-975)AAG>AAA	p.K325K	PTPN5_uc001mpb.2_Silent_p.K293K|PTPN5_uc001mpc.2_Silent_p.K325K|PTPN5_uc001mpe.2_Silent_p.K293K|PTPN5_uc010rdj.1_Silent_p.K269K|PTPN5_uc001mpf.2_Silent_p.K301K|PTPN5_uc010rdk.1_Silent_p.K270K	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	325	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						TGTACCGGTTCTTCCGCACCA	0.582													26	20					0	0	0.000878237	0	0
SLC6A5	9152	broad.mit.edu	37	11	20648277	20648277	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:20648277C>T	uc001mqd.2	+	8	1557	c.1284C>T	c.(1282-1284)TTC>TTT	p.F428F	SLC6A5_uc009yic.2_Silent_p.F193F	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	428	Helical; Name=5; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CGGCCACGTTCCCGTATGTCG	0.577													34	21					0	0	0.000953801	0	0
NELL1	4745	broad.mit.edu	37	11	20805360	20805360	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:20805360C>T	uc001mqe.2	+	3	472	c.319C>T	c.(319-321)CGA>TGA	p.R107*	NELL1_uc001mqf.2_Nonsense_Mutation_p.R107*|NELL1_uc009yid.2_Nonsense_Mutation_p.R135*|NELL1_uc010rdo.1_Nonsense_Mutation_p.R107*|NELL1_uc010rdp.1_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	107	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						ACTGTCCATTCGAGAACTGGA	0.418													42	22					0	0	0.00222228	0	0
SLC17A6	57084	broad.mit.edu	37	11	22399035	22399035	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:22399035G>A	uc001mqk.2	+	12	1911	c.1498G>A	c.(1498-1500)GGA>AGA	p.G500R		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	500	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						ATTTGCCTCAGGAGAGAAACA	0.438													14	22					0	0	0.00185496	0	0
SLC17A6	57084	broad.mit.edu	37	11	22399270	22399270	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:22399270G>A	uc001mqk.2	+	12	2146	c.1733G>A	c.(1732-1734)CGA>CAA	p.R578Q		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	578	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						TATAAGGACCGAGTTGATTAT	0.353													10	16					0	0	0.000673444	0	0
ANO3	63982	broad.mit.edu	37	11	26569067	26569067	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:26569067G>A	uc001mqt.3	+	12	1404	c.1259G>A	c.(1258-1260)GGA>GAA	p.G420E	ANO3_uc010rdr.1_Missense_Mutation_p.G404E|ANO3_uc010rds.1_Missense_Mutation_p.G259E|ANO3_uc010rdt.1_Missense_Mutation_p.G274E	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	420	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTCTTCTATGGATTATTTACA	0.348													63	69					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	11	31115625	31115625	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:31115625G>A	uc009yjk.1	-	4	503	c.434C>T	c.(433-435)CCT>CTT	p.P145L	uc009yjl.1_Missense_Mutation_p.P73L|DCDC1_uc001msu.1_Missense_Mutation_p.P316L					RecName: Full=Doublecortin domain-containing protein 5;																		ACTGGCTACAGGCCACAGGAT	0.532													64	51					0	0	0.000781405	0	0
EHF	26298	broad.mit.edu	37	11	34664228	34664228	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:34664228C>T	uc001mvr.1	+	2	162	c.51C>T	c.(49-51)CTC>CTT	p.L17L	EHF_uc009yke.1_Silent_p.L17L|EHF_uc009ykf.1_Silent_p.L20L	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	17					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			GCAACAACCTCCTTCACCAGC	0.537													13	26					0	0	0.00244969	0	0
RAG2	5897	broad.mit.edu	37	11	36615435	36615435	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:36615435C>T	uc001mwv.3	-	2	472	c.284G>A	c.(283-285)GGA>GAA	p.G95E	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	95					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TGTTTTCCCTCCATGGATGAT	0.423									Familial_Hemophagocytic_Lymphohistiocytosis				27	98					0	0	0.001512	0	0
ARHGAP1	392	broad.mit.edu	37	11	46702650	46702650	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:46702650G>A	uc001ndd.2	-	7	615	c.546C>T	c.(544-546)TTC>TTT	p.F182F		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	182	CRAL-TRIO.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		TCTTCTGCCCGAACTTGAAGC	0.602													15	44					0	0	0.000422831	0	0
CKAP5	9793	broad.mit.edu	37	11	46766034	46766034	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:46766034G>A	uc001ndi.1	-	43	5908	c.5798C>T	c.(5797-5799)TCT>TTT	p.S1933F	CKAP5_uc009ylg.1_Missense_Mutation_p.S1826F|CKAP5_uc001ndj.1_Missense_Mutation_p.S1873F|CKAP5_uc001ndh.1_Missense_Mutation_p.S862F	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1933					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						CAAGTAGACAGATGGCCCCAC	0.522													28	67					0	0	0.000720815	0	0
MADD	8567	broad.mit.edu	37	11	47330884	47330884	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:47330884C>T	uc001ner.1	+	27	4175	c.3984C>T	c.(3982-3984)TTC>TTT	p.F1328F	MADD_uc001neq.2_Silent_p.F1269F|MADD_uc001nev.1_Silent_p.F1226F|MADD_uc001nes.1_Silent_p.F1246F|MADD_uc001net.1_Silent_p.F1289F|MADD_uc009yln.1_Silent_p.F1222F|MADD_uc001neu.1_Silent_p.F1226F|MADD_uc001nex.2_Silent_p.F1328F|MADD_uc001nez.2_Silent_p.F1225F|MADD_uc001new.2_Silent_p.F1268F|MADD_uc009ylo.2_Silent_p.F242F	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1328					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		AAGATGCCTTCTTAGATGCTG	0.453													53	22					0	0	0.000781405	0	0
PSMC3	5702	broad.mit.edu	37	11	47444385	47444385	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:47444385G>A	uc001nfh.2	-	7	925	c.731C>T	c.(730-732)ACT>ATT	p.T244I	PSMC3_uc009ylr.1_Missense_Mutation_p.T202I	NM_002804	NP_002795	P17980	PRS6A_HUMAN	proteasome 26S ATPase subunit 3	244					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|nucleoside-triphosphatase activity|protein binding|transcription coactivator activity|transcription corepressor activity			ovary(4)	4				Lung(87;0.0932)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ACTCACCTTAGTCTGTGCGGC	0.587													53	103					0	0	0.000781405	0	0
MTCH2	23788	broad.mit.edu	37	11	47656245	47656245	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:47656245G>A	uc010rho.1	-	5	537	c.348C>T	c.(346-348)TCC>TCT	p.S116S	MTCH2_uc001nge.2_5'UTR|MTCH2_uc010rhp.1_5'UTR	NM_014342	NP_055157	Q9Y6C9	MTCH2_HUMAN	mitochondrial carrier 2	116					transport	integral to membrane|mitochondrial inner membrane					0						CGTGGTCAAAGGAAGATGAGA	0.353													8	29					0	0	0.000978159	0	0
OR4X2	119764	broad.mit.edu	37	11	48266696	48266696	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:48266696A>C	uc001ngs.1	+	1	41	c.41A>C	c.(40-42)GAG>GCG	p.E14A		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCAACCAGGAGGTGCAGAGG	0.448													17	55					0	0	0.000958276	0	0
OR4X2	119764	broad.mit.edu	37	11	48266881	48266881	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:48266881G>A	uc001ngs.1	+	1	226	c.226G>A	c.(226-228)GAT>AAT	p.D76N		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	76	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ACTCATCTCAGATCTGCTGGC	0.512													67	46					0	0	0.000781405	0	0
OR4C3	256144	broad.mit.edu	37	11	48346564	48346564	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:48346564C>T	uc010rhv.1	+	1	72	c.72C>T	c.(70-72)ACC>ACT	p.T24T		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TCTCAGTGACCTTGGAATCTA	0.393													41	76					0	0	0.00170553	0	0
OR4C3	256144	broad.mit.edu	37	11	48346987	48346987	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:48346987C>T	uc010rhv.1	+	1	495	c.495C>T	c.(493-495)CTC>CTT	p.L165L		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	138	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCAGGCATCTCTGTGCCATGC	0.537													19	60					0	0	0.00121646	0	0
OR4A47	403253	broad.mit.edu	37	11	48510455	48510455	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:48510455G>A	uc010rhx.1	+	1	111	c.111G>A	c.(109-111)ATG>ATA	p.M37I		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTTTGACCATGGTGGGCAACC	0.418													15	8					0	0	0.000422831	0	0
LOC440040	440040	broad.mit.edu	37	11	49597918	49597918	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:49597918T>A	uc010rhy.1	+	2	509	c.31T>A	c.(31-33)TTT>ATT	p.F11I	LOC440040_uc009ymb.2_Missense_Mutation_p.F11I	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						TGGAGCTCTCTTTTCTGTTCA	0.512													14	5					0	0	0.00244969	0	0
OR4P4	81300	broad.mit.edu	37	11	55406571	55406571	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:55406571C>T	uc010rij.1	+	1	738	c.738C>T	c.(736-738)GTC>GTT	p.V246V		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTGTTGTGGTCCTGTTTTTTG	0.388													47	75					0	0	0.000781405	0	0
OR5D18	219438	broad.mit.edu	37	11	55587893	55587893	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:55587893C>A	uc010rin.1	+	1	788	c.788C>A	c.(787-789)CCC>CAC	p.P263H		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TACTGTGTGCCCAACTCCAAA	0.522													19	54					1.78486e-19	6.13267e-19	0.000958276	1	0
OR5D16	390144	broad.mit.edu	37	11	55606570	55606570	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:55606570A>T	uc010rio.1	+	1	343	c.343A>T	c.(343-345)ATT>TTT	p.I115F		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GACTGAATTAATTCTATTTGC	0.438													63	90					0	0	0.000781405	0	0
OR8K5	219453	broad.mit.edu	37	11	55927433	55927433	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:55927433C>T	uc010rja.1	-	1	361	c.361G>A	c.(361-363)GAC>AAC	p.D121N		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ACATAGCGGTCATAGGCCATG	0.418													48	50					0	0	0.000680045	0	0
OR5T2	219464	broad.mit.edu	37	11	56000154	56000154	+	Silent	SNP	G	A	A	rs142863951	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:56000154G>A	uc010rjc.1	-	1	508	c.508C>T	c.(508-510)CTG>TTG	p.L170L		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	170	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ACTGAATACAGGAGAGGGTTG	0.438													59	74					0	0	0.000781405	0	0
OR5T3	390154	broad.mit.edu	37	11	56020462	56020462	+	Missense_Mutation	SNP	G	A	A	rs141819352		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:56020462G>A	uc010rjd.1	+	1	787	c.787G>A	c.(787-789)GGA>AGA	p.G263R		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	263	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TTCTGCTAAGGGAAGGCAAAA	0.413													82	95					0	0	0.000781405	0	0
OR5T3	390154	broad.mit.edu	37	11	56020467	56020467	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:56020467G>A	uc010rjd.1	+	1	792	c.792G>A	c.(790-792)AGG>AGA	p.R264R		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	264	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					CTAAGGGAAGGCAAAAGGCCT	0.413													75	93					0	0	0.000781405	0	0
OR5M1	390168	broad.mit.edu	37	11	56380885	56380885	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:56380885G>A	uc001nja.1	-	1	94	c.94C>T	c.(94-96)CTT>TTT	p.L32F		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	32	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TAGATCGCAAGGAATACCCCA	0.483													24	62					0	0	0.000720815	0	0
APLNR	187	broad.mit.edu	37	11	57004301	57004301	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:57004301T>C	uc001njo.2	-	1	627	c.178A>G	c.(178-180)AAG>GAG	p.K60E	APLNR_uc001njn.3_RNA	NM_005161	NP_005152	P35414	APJ_HUMAN	apelin receptor	60	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			lung(5)|ovary(1)	6						GAGCGCCTCTTCTCCCGGCTG	0.622													25	14					0	0	0.000720815	0	0
P2RX3	5024	broad.mit.edu	37	11	57137384	57137384	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:57137384G>A	uc001nju.2	+	12	1184	c.1108G>A	c.(1108-1110)GCT>ACT	p.A370T		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	370	Cytoplasmic (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						GAAAATCGCGGCTTTGACCAA	0.552													4	27					0	0	0.00116845	0	0
PRG2	5553	broad.mit.edu	37	11	57156618	57156618	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:57156618G>A	uc001njz.2	-	2	258	c.231C>T	c.(229-231)ATC>ATT	p.I77I	PRG2_uc001njw.1_RNA|PRG2_uc001njx.1_RNA|PRG2_uc001njy.1_RNA|PRG2_uc001nka.2_Silent_p.I77I|PRG2_uc001nkb.2_Silent_p.I77I|PRG2_uc001nkd.2_Silent_p.I77I|PRG2_uc001nkc.2_Silent_p.I77I|PRG2_uc001nke.2_Silent_p.I357I	NM_002728	NP_002719	P13727	PRG2_HUMAN	proteoglycan 2 preproprotein	77					defense response to bacterium|immune response	extracellular region|transport vesicle	heparin binding|sugar binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Sargramostim(DB00020)	CTGGCACTGAGATAGACTCAA	0.557													79	41					0	0	0.000781405	0	0
OR5B12	390191	broad.mit.edu	37	11	58206865	58206865	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:58206865T>A	uc010rkh.1	-	1	760	c.760A>T	c.(760-762)ATC>TTC	p.I254F		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	254	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TACATAAAGATTCCTGTCCCA	0.453													27	15					0	0	0.001512	0	0
OR10V1	390201	broad.mit.edu	37	11	59480591	59480591	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:59480591G>A	uc001nof.1	-	1	728	c.728C>T	c.(727-729)TCT>TTT	p.S243F		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	243	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GATGTGAGAAGAGCAGGTAGA	0.527													15	26					0	0	0.000422831	0	0
ZP1	22917	broad.mit.edu	37	11	60635174	60635174	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:60635174G>A	uc001nqd.2	+	1	160	c.140G>A	c.(139-141)GGA>GAA	p.G47E	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	47	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						GGGATCAAGGGAATGCAGCTG	0.682													20	9					0	0	0.00188189	0	0
DAGLA	747	broad.mit.edu	37	11	61507965	61507965	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:61507965T>C	uc001nsa.2	+	18	1995	c.1884T>C	c.(1882-1884)TTT>TTC	p.F628F		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	628	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CCACATACTTTGCCATCTGGG	0.607													47	88					0	0	0.000781405	0	0
C11orf9	745	broad.mit.edu	37	11	61543821	61543821	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:61543821G>A	uc001nsc.1	+	10	1512	c.1416G>A	c.(1414-1416)ACG>ACA	p.T472T	C11orf9_uc001nse.1_Silent_p.T463T|C11orf9_uc010rll.1_5'Flank	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	472	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						AGCAGGTCACGAAGGTGACTG	0.657											OREG0021012	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	6					0	0	0.000442599	0	0
FADS3	3995	broad.mit.edu	37	11	61643405	61643405	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:61643405G>A	uc001nsm.2	-	11	1357	c.1204C>T	c.(1204-1206)CCG>TCG	p.P402S	FADS3_uc001nsn.2_Missense_Mutation_p.P287S	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	402	Cytoplasmic (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						TTGACCAGCGGGGCCACCCGG	0.652													40	79					0	0	0.00222228	0	0
BEST1	7439	broad.mit.edu	37	11	61727035	61727035	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:61727035C>T	uc001nss.2	+	8	1513	c.933C>T	c.(931-933)GTC>GTT	p.V311V	BEST1_uc010rlq.1_Missense_Mutation_p.S319L|BEST1_uc010rlr.1_Intron|BEST1_uc010rls.1_Intron|BEST1_uc001nsr.2_Silent_p.V251V|BEST1_uc009ynt.2_RNA|BEST1_uc010rlt.1_Silent_p.V251V|BEST1_uc001nst.2_Intron|BEST1_uc010rlu.1_Missense_Mutation_p.S273L|BEST1_uc010rlv.1_Silent_p.V205V	NM_004183	NP_004174	O76090	BEST1_HUMAN	bestrophin 1 isoform 1	311	Cytoplasmic (Potential).		V -> G (in VMD2).		response to stimulus|transepithelial chloride transport|visual perception	basolateral plasma membrane|chloride channel complex|cytosol|membrane fraction	chloride channel activity			central_nervous_system(1)	1						ACTGGATTGTCGACAGGAATT	0.537													24	16					0	0	0.00047179	0	0
AHNAK	79026	broad.mit.edu	37	11	62291668	62291668	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:62291668G>A	uc001ntl.2	-	5	10521	c.10221C>T	c.(10219-10221)TTC>TTT	p.F3407F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3407					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				AAATACTCAGGAAAGGCATTT	0.388													48	33					0	0	0.000781405	0	0
AHNAK	79026	broad.mit.edu	37	11	62298472	62298472	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:62298472G>A	uc001ntl.2	-	5	3717	c.3417C>T	c.(3415-3417)CTC>CTT	p.L1139L	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1139					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTCGCCTTTGAGGCTGGGCA	0.532													88	60					0	0	0.000781405	0	0
B3GAT3	26229	broad.mit.edu	37	11	62389381	62389381	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:62389381G>A	uc001ntw.2	-	1	68	c.39C>T	c.(37-39)TTC>TTT	p.F13F	B3GAT3_uc009ynz.2_5'UTR|B3GAT3_uc001ntx.2_RNA|B3GAT3_uc010rlz.1_Silent_p.F13F	NM_012200	NP_036332	O94766	B3GA3_HUMAN	beta-1,3-glucuronyltransferase 3	13	Helical; Signal-anchor for type II membrane protein; (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|manganese ion binding				0						TCGACACCAGGAAGTAGGCGA	0.403													35	26					0	0	0.00285205	0	0
GANAB	23193	broad.mit.edu	37	11	62398174	62398174	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:62398174C>T	uc001nub.2	-	11	1318	c.1285G>A	c.(1285-1287)GAC>AAC	p.D429N	GANAB_uc001nua.2_Missense_Mutation_p.D451N|GANAB_uc001nuc.2_Missense_Mutation_p.D332N|GANAB_uc010rma.1_Missense_Mutation_p.D337N|GANAB_uc010rmb.1_Missense_Mutation_p.D315N	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	429					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						TGTTCAATGTCTAGCCAGATG	0.562													17	38					0	0	0.000422831	0	0
STX5	6811	broad.mit.edu	37	11	62592792	62592792	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:62592792G>A	uc001nvh.2	-	7	714	c.560C>T	c.(559-561)TCC>TTC	p.S187F	STX5_uc010rmi.1_Missense_Mutation_p.S91F|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Missense_Mutation_p.S133F|STX5_uc010rmj.1_Missense_Mutation_p.S187F|STX5_uc001nvj.2_Missense_Mutation_p.S2F	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	187	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						GAAGTCATTGGACATAGAAGC	0.483													120	237					0	0	0.000781405	0	0
WDR74	54663	broad.mit.edu	37	11	62601757	62601757	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:62601757G>A	uc001nvm.1	-	9	934	c.766C>T	c.(766-768)CTT>TTT	p.L256F	STX5_uc001nvh.2_5'Flank|STX5_uc010rmi.1_5'Flank|STX5_uc009yoh.2_5'Flank|STX5_uc001nvi.2_5'Flank|STX5_uc010rmj.1_5'Flank|STX5_uc001nvj.2_5'Flank|WDR74_uc001nvk.1_Missense_Mutation_p.L199F|WDR74_uc001nvl.1_Missense_Mutation_p.L256F|WDR74_uc001nvn.1_Missense_Mutation_p.L308F|WDR74_uc009yoi.1_Missense_Mutation_p.L256F	NM_018093	NP_060563	Q6RFH5	WDR74_HUMAN	WD repeat domain 74	256	WD 5.					nucleolus				ovary(1)	1						CCTTGCCGAAGGTCAATTTCT	0.478													79	54					0	0	0.000781405	0	0
HRASLS5	117245	broad.mit.edu	37	11	63235936	63235936	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:63235936C>T	uc001nwy.2	-	4	551	c.377G>A	c.(376-378)GGA>GAA	p.G126E	HRASLS5_uc001nwz.2_Missense_Mutation_p.G116E|HRASLS5_uc010rmq.1_Missense_Mutation_p.G126E|HRASLS5_uc009yos.2_Intron	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	126										ovary(1)	1						TCTTGGTTTTCCCTATAATGG	0.453													36	19					0	0	0.000814825	0	0
FLRT1	23769	broad.mit.edu	37	11	63884858	63884858	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:63884858C>T	uc001nyi.1	+	2	1460	c.1119C>T	c.(1117-1119)AGC>AGT	p.S373S	MACROD1_uc001nyh.2_Intron	NM_013280	NP_037412	Q9NZU1	FLRT1_HUMAN	fibronectin leucine rich transmembrane protein	345	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity				0						ACATTACCAGCGAGATGGACG	0.682													23	24					0	0	0.000586117	0	0
NRXN2	9379	broad.mit.edu	37	11	64428249	64428249	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:64428249A>T	uc001oar.2	-	11	2600	c.2161T>A	c.(2161-2163)TTT>ATT	p.F721I	NRXN2_uc001oas.2_Missense_Mutation_p.F690I|NRXN2_uc001oaq.2_Missense_Mutation_p.F388I	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CGCCCAAGAAAGCCGGTCCCG	0.602													13	50					0	0	0.00244969	0	0
MAP4K2	5871	broad.mit.edu	37	11	64568600	64568600	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:64568600G>A	uc001obh.2	-	8	605	c.513C>T	c.(511-513)TTC>TTT	p.F171F	MAP4K2_uc001obi.2_Silent_p.F171F	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	171	Protein kinase.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						GAGTCCCAATGAAAGACCTCC	0.637													29	16					0	0	0.00178596	0	0
EHD1	10938	broad.mit.edu	37	11	64622318	64622318	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:64622318C>T	uc001obu.1	-	5	1347	c.1092G>A	c.(1090-1092)CAG>CAA	p.Q364Q	EHD1_uc001obt.1_Silent_p.Q47Q|EHD1_uc001obv.1_Silent_p.Q364Q|EHD1_uc010rnq.1_Silent_p.Q378Q	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	364					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						AGTCCTGGGTCTGCAGGAGTT	0.627													59	156					0	0	0.000781405	0	0
EHD1	10938	broad.mit.edu	37	11	64645688	64645688	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:64645688G>A	uc001obu.1	-	1	504	c.249C>T	c.(247-249)TTC>TTT	p.F83F	EHD1_uc001obv.1_Silent_p.F83F|EHD1_uc010rnq.1_Silent_p.F97F	NM_006795	NP_006786	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	83					blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding				0						GCATCCCCGGGAAGTCCTGCT	0.657													34	22					0	0	0.000692331	0	0
C11orf85	283129	broad.mit.edu	37	11	64722257	64722257	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:64722257T>G	uc001ocb.1	-	3	193	c.119A>C	c.(118-120)AAT>ACT	p.N40T	C11orf85_uc001occ.1_RNA|C11orf85_uc001ocd.1_Missense_Mutation_p.N40T	NM_001037225	NP_001032302	Q3KP22	CK085_HUMAN	hypothetical protein LOC283129	40											0						GACTTCCTTATTTTCTATCTC	0.403													16	35					0	0	0.00074312	0	0
BATF2	116071	broad.mit.edu	37	11	64756792	64756792	+	Missense_Mutation	SNP	C	T	T	rs139572037		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:64756792C>T	uc001ocf.1	-	3	765	c.634G>A	c.(634-636)GAG>AAG	p.E212K	BATF2_uc001oce.1_Missense_Mutation_p.E127K	NM_138456	NP_612465	Q8N1L9	BATF2_HUMAN	basic leucine zipper transcription factor,	212						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTGGGATGCTCCAGCTCGAGG	0.647													20	21					0	0	0.000958276	0	0
SLC22A20	440044	broad.mit.edu	37	11	64985083	64985083	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:64985083C>T	uc010roc.1	+	3	560	c.557C>T	c.(556-558)TCC>TTC	p.S186F	SLC22A20_uc010rob.1_Missense_Mutation_p.S186F	NM_001004326	NP_001004326	A6NK97	S22AK_HUMAN	solute carrier family 22, member 20	186	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)	1						TATTTCAGCTCCTTCAGTGCC	0.617													13	19					0	0	0.00244969	0	0
CFL1	1072	broad.mit.edu	37	11	65623156	65623156	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:65623156G>T	uc001ofs.2	-	3	591	c.357C>A	c.(355-357)AGC>AGA	p.S119R	CFL1_uc001oft.2_Missense_Mutation_p.S119R|CFL1_uc001ofu.2_3'UTR	NM_005507	NP_005498	P23528	COF1_HUMAN	cofilin 1 (non-muscle)	119	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding				0				READ - Rectum adenocarcinoma(159;0.169)		CGTCCTTGGAGCTGGCATAAA	0.577													11	47					2.68362e-12	9.18164e-12	0.00136819	1	0
TSGA10IP	254187	broad.mit.edu	37	11	65715116	65715116	+	Nonsense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:65715116A>T	uc001ogk.1	+	5	852	c.820A>T	c.(820-822)AAG>TAG	p.K274*	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_Intron	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	274											0						TTGTCAGAGAAAGGGGCAGAT	0.597													15	9					0	0	0.000308642	0	0
CATSPER1	117144	broad.mit.edu	37	11	65790384	65790384	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:65790384G>A	uc001ogt.2	-	2	1503	c.1365C>T	c.(1363-1365)TTC>TTT	p.F455F		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	455	Helical; Name=Segment S1; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						GGCAGACAACGAAGAAGATGA	0.552											OREG0021092	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	61					0	0	0.00152264	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793566	65793566	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:65793566G>A	uc001ogt.2	-	1	423	c.285C>T	c.(283-285)GGC>GGT	p.G95G		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	95	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						CCAGACCAAAGCCTGTGGGGC	0.597													66	53					0	0	0.000781405	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65811014	65811014	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:65811014G>A	uc001ogv.2	-	2	420	c.260C>T	c.(259-261)GCC>GTC	p.A87V	GAL3ST3_uc001ogw.2_Missense_Mutation_p.A87V	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	87	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						GTGGCGCTCGGCAAAGCGAAA	0.657													9	24					0	0	0.000274275	0	0
BRMS1	25855	broad.mit.edu	37	11	66105737	66105737	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:66105737G>A	uc001ohp.1	-	9	857	c.710C>T	c.(709-711)TCC>TTC	p.S237F	RIN1_uc010roy.1_5'Flank|RIN1_uc009yrd.1_5'Flank|RIN1_uc001ohn.1_5'Flank|RIN1_uc010roz.1_5'Flank|RIN1_uc010rpa.1_5'Flank|BRMS1_uc001oho.1_Missense_Mutation_p.S237F|BRMS1_uc009yre.2_3'UTR	NM_015399	NP_056214	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1 isoform 1	237					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding				0						CTTCTGAGGGGACACAGCTGC	0.592													6	5					0	0	0.00116845	0	0
ACTN3	89	broad.mit.edu	37	11	66321562	66321562	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:66321562C>T	uc001oio.1	+	4	447	c.429C>T	c.(427-429)ACC>ACT	p.T143T	ACTN3_uc010rpi.1_RNA	NM_001104	NP_001095	Q08043	ACTN3_HUMAN	actinin, alpha 3	143	Actin-binding.|CH 1.				focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle				0						TGATCTGGACCATCATCCTTC	0.448													11	20					0	0	0.00185496	0	0
C11orf80	79703	broad.mit.edu	37	11	66571646	66571646	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:66571646G>A	uc001ojf.2	+	9	1030	c.1023G>A	c.(1021-1023)AGG>AGA	p.R341R	C11orf80_uc001ojg.2_Silent_p.R107R|C11orf80_uc001ojh.2_Silent_p.R108R|C11orf80_uc001oji.2_Silent_p.R108R|C11orf80_uc010rpk.1_Silent_p.R176R	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	186											0						AGCTTAACAGGATTTCTTCAG	0.428													17	21					0	0	0.000422831	0	0
ACY3	91703	broad.mit.edu	37	11	67410210	67410210	+	Silent	SNP	C	T	T	rs139551384		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:67410210C>T	uc001omq.2	-	8	1116	c.945G>A	c.(943-945)CCG>CCA	p.P315P		NM_080658	NP_542389	Q96HD9	ACY3_HUMAN	aspartoacylase 3	315					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	AAGCTGGGCTCGGGGCAGGGG	0.582													57	36					0	0	0.000781405	0	0
C11orf24	53838	broad.mit.edu	37	11	68029501	68029501	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:68029501G>A	uc001onr.3	-	4	1404	c.962C>T	c.(961-963)TCC>TTC	p.S321F	C11orf24_uc001ons.2_Missense_Mutation_p.S321F	NM_022338	NP_071733	Q96F05	CK024_HUMAN	hypothetical protein LOC53838 precursor	321	Extracellular (Potential).|Pro-rich.					integral to membrane					0						TGTCGTGGGGGACATGGCCTC	0.637													37	20					0	0	0.00128727	0	0
MTL5	9633	broad.mit.edu	37	11	68514739	68514739	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:68514739G>A	uc001ooc.2	-	3	707	c.567C>T	c.(565-567)TTC>TTT	p.F189F	MTL5_uc001ood.1_Silent_p.F189F|MTL5_uc009ysi.1_Silent_p.F189F|MTL5_uc001ooe.2_Silent_p.F189F	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	189					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			GGGACGATGGGAACTTGCAAC	0.418													31	18					0	0	0.00209593	0	0
MRPL21	219927	broad.mit.edu	37	11	68658812	68658812	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:68658812G>A	uc001ooi.2	-	7	630	c.605C>T	c.(604-606)CCG>CTG	p.P202L	MRPL21_uc001ooh.2_Missense_Mutation_p.P117L	NM_181514	NP_852615	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21 isoform d	202					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAACAAACACGGAGCAATCTC	0.463													65	149					0	0	0.000781405	0	0
INPPL1	3636	broad.mit.edu	37	11	71948326	71948326	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:71948326C>T	uc001osf.2	+	26	3185	c.3038C>T	c.(3037-3039)ACC>ATC	p.T1013I	INPPL1_uc001osg.2_Missense_Mutation_p.T771I	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1013	Pro-rich.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CCATCTGCCACCAAGAACAAA	0.627													40	91					0	0	0.00195071	0	0
PDE2A	5138	broad.mit.edu	37	11	72290592	72290592	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:72290592G>A	uc010rrc.1	-	26	2485	c.2242C>T	c.(2242-2244)CAT>TAT	p.H748Y	PDE2A_uc001oso.2_Missense_Mutation_p.H727Y|PDE2A_uc010rra.1_Missense_Mutation_p.H741Y|PDE2A_uc001osn.2_Missense_Mutation_p.H492Y|PDE2A_uc010rrb.1_Missense_Mutation_p.H739Y|PDE2A_uc010rrd.1_Missense_Mutation_p.H633Y	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	748	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CGGGAGAAATGATCAAAGATG	0.408													34	86					0	0	0.000953801	0	0
PDE2A	5138	broad.mit.edu	37	11	72300278	72300278	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:72300278C>T	uc010rrc.1	-	12	1123	c.880G>A	c.(880-882)GGA>AGA	p.G294R	PDE2A_uc001oso.2_Missense_Mutation_p.G273R|PDE2A_uc010rra.1_Missense_Mutation_p.G287R|PDE2A_uc001osn.2_Intron|PDE2A_uc010rrb.1_Missense_Mutation_p.G285R|PDE2A_uc010rrd.1_Missense_Mutation_p.G179R	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	294	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CCCAGGCATCCTGTCAACTAG	0.572													45	131					0	0	0.000781405	0	0
ARAP1	116985	broad.mit.edu	37	11	72410593	72410593	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:72410593G>A	uc001osu.2	-	17	2496	c.2307C>T	c.(2305-2307)TTC>TTT	p.F769F	ARAP1_uc001osv.2_Silent_p.F769F|ARAP1_uc001osr.2_Silent_p.F529F|ARAP1_uc001oss.2_Silent_p.F524F|ARAP1_uc009yth.2_Silent_p.F463F|ARAP1_uc010rre.1_Silent_p.F524F|ARAP1_uc001osw.1_Silent_p.F57F	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	769	PH 3.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						AGCGCCGGCTGAACTCTGGGG	0.617													51	111					0	0	0.000781405	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73021159	73021159	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:73021159G>A	uc001otu.2	+	1	1497	c.1476G>A	c.(1474-1476)GGG>GGA	p.G492G		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	492					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						AACCTGGTGGGAGCTCCGGGG	0.597													27	25					0	0	0.0024448	0	0
SLCO2B1	11309	broad.mit.edu	37	11	74911427	74911427	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:74911427C>T	uc001owb.2	+	11	2145	c.1758C>T	c.(1756-1758)ATC>ATT	p.I586I	SLCO2B1_uc010rrq.1_Silent_p.I331I|SLCO2B1_uc010rrr.1_Silent_p.I442I|SLCO2B1_uc010rrs.1_Silent_p.I470I|SLCO2B1_uc001owc.2_Silent_p.I359I|SLCO2B1_uc001owd.2_Silent_p.I564I	NM_007256	NP_009187	O94956	SO2B1_HUMAN	solute carrier organic anion transporter family,	586	Helical; Name=10; (Potential).				sodium-independent organic anion transport	integral to membrane	sodium-independent organic anion transmembrane transporter activity			ovary(1)|breast(1)	2					Ergoloid mesylate(DB01049)	TCATGCTCATCCTAAGGTGAA	0.602													24	75					0	0	0.00047179	0	0
ARRB1	408	broad.mit.edu	37	11	74993017	74993017	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:74993017C>T	uc001owe.1	-	6	625	c.403G>A	c.(403-405)GAC>AAC	p.D135N	ARRB1_uc001owf.1_Missense_Mutation_p.D135N	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	135	Interaction with SRC (By similarity).				G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						TTCCCCGTGTCTTCGGGCCCC	0.592													13	28					0	0	0.000422831	0	0
C11orf30	56946	broad.mit.edu	37	11	76255759	76255759	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:76255759C>T	uc001oxl.2	+	19	3309	c.3166C>T	c.(3166-3168)CCT>TCT	p.P1056S	C11orf30_uc001oxm.2_Missense_Mutation_p.P958S|C11orf30_uc010rsb.1_Missense_Mutation_p.P1071S|C11orf30_uc010rsc.1_Missense_Mutation_p.P1057S|C11orf30_uc001oxn.2_Missense_Mutation_p.P1057S|C11orf30_uc010rsd.1_Missense_Mutation_p.P965S|C11orf30_uc001oxo.1_Missense_Mutation_p.P410S|C11orf30_uc010rse.1_Missense_Mutation_p.P303S|C11orf30_uc001oxp.2_Missense_Mutation_p.P156S	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	1056	Gln-rich.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						GCAGCAGCTCCCTAAACTGCA	0.552													14	55					0	0	0.00185496	0	0
GDPD4	220032	broad.mit.edu	37	11	76944136	76944136	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:76944136C>T	uc001oyf.2	-	13	1574	c.1323G>A	c.(1321-1323)AGG>AGA	p.R441R		NM_182833	NP_878253	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain	441	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			skin(1)	1						CTGAGTTAATCCTGGAGCACC	0.468													27	18					0	0	0.001512	0	0
PAK1	5058	broad.mit.edu	37	11	77066759	77066759	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:77066759C>T	uc001oyh.3	-	7	1259	c.726G>A	c.(724-726)CAG>CAA	p.Q242Q	PAK1_uc010rso.1_Silent_p.Q144Q|PAK1_uc001oyg.3_Silent_p.Q242Q|PAK1_uc001oyi.1_Silent_p.Q242Q|PAK1_uc010rsn.1_Intron	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	242	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					GCTTCTTCTTCTGCTTCTCAG	0.438													69	55					0	0	0.000781405	0	0
INTS4	92105	broad.mit.edu	37	11	77614629	77614629	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:77614629A>G	uc001oys.2	-	17	2082	c.2054T>C	c.(2053-2055)TTG>TCG	p.L685S	C11orf67_uc001oyp.2_Intron|INTS4_uc001oyt.2_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	685					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			CTTCAAATACAAAGGGGCAGC	0.478													3	56					0	0	0.00024832	0	0
ODZ4	26011	broad.mit.edu	37	11	78399209	78399209	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:78399209C>T	uc001ozl.3	-	29	5613	c.5150G>A	c.(5149-5151)CGA>CAA	p.R1717Q	ODZ4_uc009yvb.1_Missense_Mutation_p.R301Q	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1717	YD 4.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TGTATCACTTCGGAAACTGCT	0.517													47	108					0	0	0.000781405	0	0
ODZ4	26011	broad.mit.edu	37	11	78412817	78412817	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:78412817C>T	uc001ozl.3	-	28	5304	c.4841G>A	c.(4840-4842)GGG>GAG	p.G1614E	ODZ4_uc009yvb.1_Missense_Mutation_p.G198E	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1614	Extracellular (Potential).|YD 2.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GTCGCCGTCCCCAGTGTAGGT	0.547													63	46					0	0	0.000781405	0	0
FAT3	120114	broad.mit.edu	37	11	92532464	92532464	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:92532464G>A	uc001pdj.3	+	9	6302	c.6285G>A	c.(6283-6285)GTG>GTA	p.V2095V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2095	Cadherin 19.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTGTTCAAGTGGATGCGGAAC	0.483										TCGA Ovarian(4;0.039)			303	39					0	0	0.000781405	0	0
HEPHL1	341208	broad.mit.edu	37	11	93836140	93836140	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:93836140C>T	uc001pep.2	+	15	2793	c.2636C>T	c.(2635-2637)CCC>CTC	p.P879L	uc001pen.1_Intron	NM_001098672	NP_001092142	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1 precursor	879	Plastocyanin-like 5.|Extracellular (Potential).				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			ovary(3)	3		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CCTTCTGATCCCAATTGTATT	0.333													24	4					0	0	0.000878237	0	0
PANX1	24145	broad.mit.edu	37	11	93912978	93912978	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:93912978C>T	uc001per.2	+	4	1141	c.756C>T	c.(754-756)ATC>ATT	p.I252I	PANX1_uc001peq.2_Silent_p.I252I	NM_015368	NP_056183	Q96RD7	PANX1_HUMAN	pannexin 1	252	Extracellular (Potential).				positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AATCAGGGATCCTGAGAAACG	0.478													55	4					0	0	0.000781405	0	0
CNTN5	53942	broad.mit.edu	37	11	100141950	100141950	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:100141950G>A	uc001pga.2	+	18	2630	c.2291G>A	c.(2290-2292)CGA>CAA	p.R764Q	CNTN5_uc001pfz.2_Missense_Mutation_p.R764Q|CNTN5_uc001pgb.2_Missense_Mutation_p.R690Q|CNTN5_uc010ruk.1_Missense_Mutation_p.R35Q	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	764	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACCCCATCTCGAATGATCCGC	0.448													21	3					0	0	0.00229938	0	0
CNTN5	53942	broad.mit.edu	37	11	100179157	100179157	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:100179157G>A	uc001pga.2	+	21	3026	c.2687G>A	c.(2686-2688)TGG>TAG	p.W896*	CNTN5_uc001pfz.2_Nonsense_Mutation_p.W896*|CNTN5_uc001pgb.2_Nonsense_Mutation_p.W822*|CNTN5_uc010ruk.1_Nonsense_Mutation_p.W167*	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	896	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTTGTTGCATGGAAACACATT	0.393													22	3					0	0	0.000586117	0	0
PGR	5241	broad.mit.edu	37	11	100999145	100999145	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:100999145C>T	uc001pgh.2	-	1	1400	c.657G>A	c.(655-657)GTG>GTA	p.V219V	PGR_uc001pgi.2_Silent_p.V219V|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	219	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CCTCAACCTCCACCGCAGCGG	0.711													13	2					0	0	0.000308642	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103026069	103026069	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:103026069C>T	uc001pho.2	+	25	3727	c.3583C>T	c.(3583-3585)CCT>TCT	p.P1195S	DYNC2H1_uc001phn.1_Missense_Mutation_p.P1195S|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1195	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GATCGTAATTCCTATCTTGAA	0.333													18	3					0	0	0.000566183	0	0
GRIA4	2893	broad.mit.edu	37	11	105789611	105789611	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:105789611C>T	uc001pix.2	+	11	1889	c.1443C>T	c.(1441-1443)ATC>ATT	p.I481I	GRIA4_uc001piw.2_Silent_p.I481I	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	481	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ACACAAAAATCTGGAATGGGA	0.368													20	2					0	0	0.00278032	0	0
SLC35F2	54733	broad.mit.edu	37	11	107677459	107677459	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:107677459C>T	uc001pjq.2	-	4	979	c.558G>A	c.(556-558)GGG>GGA	p.G186G	SLC35F2_uc010rvu.1_Silent_p.G38G|SLC35F2_uc001pjs.2_Silent_p.G186G	NM_017515	NP_059985	Q8IXU6	S35F2_HUMAN	solute carrier family 35, member F2	186					transport	integral to membrane				central_nervous_system(1)	1		all_cancers(61;9.46e-06)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;0.000111)|all_hematologic(158;0.000315)|all_epithelial(67;0.00197)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)|Epithelial(105;0.000105)|all cancers(92;0.00217)		TGTCTTCCCTCCCTGCTAGTA	0.418													34	9					0	0	0.00170553	0	0
NPAT	4863	broad.mit.edu	37	11	108031638	108031638	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:108031638G>A	uc001pjz.3	-	17	4277	c.4175C>T	c.(4174-4176)TCA>TTA	p.S1392L	NPAT_uc010rvv.1_Missense_Mutation_p.S448L	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	1392					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TGGTATTGATGAATTTGTAAG	0.338													24	0					0	0	0.000586117	0	0
ANKK1	255239	broad.mit.edu	37	11	113265676	113265676	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:113265676G>A	uc001pny.2	+	3	600	c.506G>A	c.(505-507)TGG>TAG	p.W169*		NM_178510	NP_848605	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	169	Protein kinase.						ATP binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|ovary(1)|breast(1)	8		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		CTGTCCAAGTGGATGGAACAG	0.567													19	2					0	0	0.00188189	0	0
HTR3A	3359	broad.mit.edu	37	11	113857256	113857256	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:113857256G>A	uc010rxb.1	+	7	973	c.740G>A	c.(739-741)CGG>CAG	p.R247Q	HTR3A_uc010rxa.1_Missense_Mutation_p.R247Q|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Missense_Mutation_p.R226Q	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	241	Extracellular (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	ATCCGCCGGCGGCCCCTCTTC	0.612													46	8					0	0	0.000781405	0	0
FAM55A	120400	broad.mit.edu	37	11	114401269	114401269	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:114401269C>T	uc001ppa.2	-	3	452	c.35G>A	c.(34-36)GGA>GAA	p.G12E	FAM55A_uc010rxd.1_5'UTR|FAM55A_uc001ppb.1_Missense_Mutation_p.G154E	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	154						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		CATCACCTTTCCTGAAGCACC	0.572													18	6					0	0	0.000958276	0	0
SIK3	23387	broad.mit.edu	37	11	116824823	116824823	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:116824823C>T	uc001ppy.2	-	3	253	c.217G>A	c.(217-219)GTT>ATT	p.V73I	SIK3_uc001ppz.2_5'UTR|SIK3_uc001pqa.2_Missense_Mutation_p.V73I	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	73	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						GTCTCCATAACCTGGTGCAAA	0.368													161	23					0	0	0.000781405	0	0
BACE1	23621	broad.mit.edu	37	11	117166040	117166040	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:117166040C>T	uc001pqz.2	-	3	835	c.374G>A	c.(373-375)CGG>CAG	p.R125Q	BACE1_uc001pqw.2_Missense_Mutation_p.R125Q|BACE1_uc001pqx.2_Missense_Mutation_p.R125Q|BACE1_uc001pqy.2_Missense_Mutation_p.R125Q|BACE1_uc001pra.1_Missense_Mutation_p.R125Q|BACE1_uc010rxg.1_Missense_Mutation_p.R25Q|BACE1_uc010rxh.1_Missense_Mutation_p.R25Q	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	125	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		CACACCCTTCCGGAGGTCCCG	0.557													23	4					0	0	0.000586117	0	0
MCAM	4162	broad.mit.edu	37	11	119181572	119181572	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:119181572C>G	uc001pwf.2	-	14	1716	c.1687G>C	c.(1687-1689)GTG>CTG	p.V563L	MCAM_uc001pwg.1_RNA	NM_006500	NP_006491	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	563	Helical; (Potential).				anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				ovary(2)|breast(1)|central_nervous_system(1)	4		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		ATCACAGCCACGATGACCACG	0.617													24	70					0	0	0.000720815	0	0
MFRP	83552	broad.mit.edu	37	11	119214621	119214621	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:119214621G>A	uc001pwj.2	-	9	1189	c.1029C>T	c.(1027-1029)TTC>TTT	p.F343F	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Intron	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		TGAAGTTGTGGAACTGTAGTT	0.577													54	5					0	0	0.000781405	0	0
TRIM29	23650	broad.mit.edu	37	11	119991312	119991312	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:119991312C>T	uc001pwz.2	-	6	1621	c.1497G>A	c.(1495-1497)CAG>CAA	p.Q499Q	TRIM29_uc001pwx.2_RNA|TRIM29_uc001pwy.2_Silent_p.Q32Q|TRIM29_uc010rzi.1_Silent_p.Q238Q|TRIM29_uc010rzj.1_Silent_p.Q232Q|TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	499					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		TGAAATTCTTCTGGGTGGTCT	0.552													19	3					0	0	0.00121646	0	0
POU2F3	25833	broad.mit.edu	37	11	120180244	120180244	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:120180244C>T	uc001pxc.2	+	10	1119	c.1017C>T	c.(1015-1017)ATC>ATT	p.I339I	POU2F3_uc010rzk.1_Silent_p.I293I|POU2F3_uc010rzl.1_Silent_p.I269I|POU2F3_uc001pxe.1_Silent_p.I124I	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	339	Homeobox.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		AGAAGCGAATCAACTGCCCTG	0.567													13	6					0	0	0.00244969	0	0
TECTA	7007	broad.mit.edu	37	11	121008598	121008598	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:121008598C>T	uc010rzo.1	+	10	3410	c.3410C>T	c.(3409-3411)TCT>TTT	p.S1137F		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1137	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGCTCAGACTCTTTCCCCAAG	0.567													22	1					0	0	0.00229938	0	0
TECTA	7007	broad.mit.edu	37	11	121039497	121039497	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:121039497G>A	uc010rzo.1	+	19	5862	c.5862G>A	c.(5860-5862)ACG>ACA	p.T1954T		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1954	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAGTGTTGACGACTCGAGATG	0.483													66	14					0	0	0.000781405	0	0
PANX3	116337	broad.mit.edu	37	11	124489263	124489263	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:124489263C>T	uc001qah.2	+	4	611	c.611C>T	c.(610-612)TCG>TTG	p.S204L		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	204	Cytoplasmic (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CGTTCACATTCGCTAGTGGCT	0.512													42	3					0	0	0.0025221	0	0
PKNOX2	63876	broad.mit.edu	37	11	125221269	125221269	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:125221269C>T	uc001qbu.2	+	4	382	c.68C>T	c.(67-69)CCC>CTC	p.P23L	PKNOX2_uc010saz.1_Intron|PKNOX2_uc010sba.1_Intron|PKNOX2_uc010sbb.1_Missense_Mutation_p.P6S	NM_022062	NP_071345	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	23	Poly-Pro.					nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		CCGCCCCCACCCTACCAGGAC	0.657													8	0					0	0	0.000442599	0	0
NFRKB	4798	broad.mit.edu	37	11	129734737	129734737	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:129734737G>A	uc001qfi.2	-	27	3984	c.3783C>T	c.(3781-3783)ATC>ATT	p.I1261I	NFRKB_uc001qfg.2_Silent_p.I1286I|NFRKB_uc001qfh.2_Silent_p.I1284I|NFRKB_uc009zcr.2_Silent_p.I547I	NM_001143835	NP_001137307	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	1261	Gln-rich.				DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			ovary(3)	3	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGACAGTCTGGATGCGCACCT	0.532													48	9					0	0	0.000781405	0	0
ST14	6768	broad.mit.edu	37	11	130066311	130066311	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:130066311C>T	uc001qfw.2	+	10	1384	c.1191C>T	c.(1189-1191)TGC>TGT	p.C397C	ST14_uc010sca.1_Silent_p.C207C	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	397	CUB 2.|Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	CGGGCACCTGCCCCAAGGACT	0.657													6	3					0	0	0.00198382	0	0
SLC6A12	6539	broad.mit.edu	37	12	305415	305416	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:305415_305416CC>TT	uc001qhz.2	-	13	1743_1744	c.1200_1201GG>AA	c.(1198-1203)GTGGAG>GTAAAG	p.E401K	SLC6A12_uc001qhx.2_Missense_Mutation_p.E58K|SLC6A12_uc001qhy.2_Intron|SLC6A12_uc001qia.2_Missense_Mutation_p.E401K|SLC6A12_uc001qib.2_Missense_Mutation_p.E401K|SLC6A12_uc009zdh.1_Missense_Mutation_p.E401K	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	401					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			ACCAGGCACTCCACACAGACAA	0.639													18	6					0	0	6.4e-05	0	0
SLC6A12	6539	broad.mit.edu	37	12	308072	308072	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:308072G>A	uc001qhz.2	-	9	1280	c.737C>T	c.(736-738)CCG>CTG	p.P246L	SLC6A12_uc001qhx.2_5'UTR|SLC6A12_uc001qhy.2_5'UTR|SLC6A12_uc001qia.2_Missense_Mutation_p.P246L|SLC6A12_uc001qib.2_Missense_Mutation_p.P246L|SLC6A12_uc009zdh.1_Missense_Mutation_p.P246L	NM_003044	NP_003035	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter	246	Helical; Name=5; (Potential).				cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			CATCAGGTACGGAAACGTGGC	0.582													23	31					0	0	0.000878237	0	0
SLC6A13	6540	broad.mit.edu	37	12	335680	335680	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:335680C>T	uc001qic.1	-	9	989	c.936G>A	c.(934-936)AGG>AGA	p.R312R	SLC6A13_uc009zdj.1_Intron|SLC6A13_uc010sdl.1_Silent_p.R220R	NM_016615	NP_057699	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter	312				Missing (in Ref. 1; AAF64247).	neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity				0	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CGATGCAGTCCCTGTGGGGCA	0.637													16	10					0	0	0.00121646	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2016677	2016677	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:2016677T>C	uc001qjp.2	-	6	941	c.710A>G	c.(709-711)AAC>AGC	p.N237S	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Missense_Mutation_p.N237S	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	237	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		TCTCTGGAAGTTCTCCACGAA	0.453													5	24					0	0	0.00198382	0	0
CACNA1C	775	broad.mit.edu	37	12	2162765	2162765	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:2162765G>A	uc009zdu.1	+	1	350	c.37G>A	c.(37-39)GAA>AAA	p.E13K	CACNA1C_uc009zdv.1_Missense_Mutation_p.E13K|CACNA1C_uc001qkb.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkc.2_Missense_Mutation_p.E13K|CACNA1C_uc001qke.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkf.2_Missense_Mutation_p.E13K|CACNA1C_uc001qjz.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkd.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkg.2_Missense_Mutation_p.E13K|CACNA1C_uc009zdw.1_Missense_Mutation_p.E13K|CACNA1C_uc001qkh.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkl.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkn.2_Missense_Mutation_p.E13K|CACNA1C_uc001qko.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkp.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkr.2_Missense_Mutation_p.E13K|CACNA1C_uc001qku.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkq.2_Missense_Mutation_p.E13K|CACNA1C_uc001qks.2_Missense_Mutation_p.E13K|CACNA1C_uc001qkt.2_Missense_Mutation_p.E13K	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	13	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CATTCCAGAGGAAAACCACCA	0.473													4	7					0	0	0.00116845	0	0
KCNA5	3741	broad.mit.edu	37	12	5155065	5155065	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:5155065G>A	uc001qni.2	+	1	1981	c.1752G>A	c.(1750-1752)GAG>GAA	p.E584E		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	584						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						GCCCCCTAGAGAAGTGTAACG	0.597													23	23					0	0	0.00047179	0	0
NTF3	4908	broad.mit.edu	37	12	5604142	5604142	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:5604142C>T	uc001qnl.3	+	1	845	c.762C>T	c.(760-762)ATC>ATT	p.I254I	NTF3_uc001qnk.3_Silent_p.I267I	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	254					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						CGAGAAAAATCGGAAGAACAT	0.363													6	19					0	0	0.00116845	0	0
ANO2	57101	broad.mit.edu	37	12	5685149	5685149	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:5685149G>A	uc001qnm.2	-	24	2544	c.2472C>T	c.(2470-2472)ATC>ATT	p.I824I		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	829	Extracellular (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						CCAGGCGGGGGATAAAGTCGG	0.517													7	9					0	0	0.00198382	0	0
TNFRSF1A	7132	broad.mit.edu	37	12	6438691	6438691	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:6438691G>A	uc001qnu.2	-	10	1436	c.1155C>T	c.(1153-1155)ATC>ATT	p.I385I	TNFRSF1A_uc001qnt.2_Silent_p.I277I|TNFRSF1A_uc010sey.1_Silent_p.I153I|TNFRSF1A_uc010sez.1_Silent_p.I277I|TNFRSF1A_uc009zek.2_Silent_p.I342I	NM_001065	NP_001056	P19438	TNR1A_HUMAN	tumor necrosis factor receptor 1 precursor	385	Death.|Cytoplasmic (Potential).				apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|inflammatory response|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of inflammatory response|positive regulation of transcription from RNA polymerase II promoter|prostaglandin metabolic process	extracellular region|integral to plasma membrane|membrane raft	tumor necrosis factor receptor activity			lung(2)|skin(1)	3						CCAGCCGATCGATCTCGTGGT	0.701													11	9					0	0	0.00244969	0	0
SCNN1A	6337	broad.mit.edu	37	12	6463683	6463683	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:6463683C>T	uc001qnx.2	-	8	1570	c.1281G>A	c.(1279-1281)AAG>AAA	p.K427K	SCNN1A_uc001qnv.2_Silent_p.K127K|SCNN1A_uc001qnw.2_Silent_p.K486K|SCNN1A_uc010sfb.1_Silent_p.K450K	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	427	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	AGCCACACTCCTTGATCATGC	0.577													24	11					0	0	0.00278032	0	0
C12orf53	196500	broad.mit.edu	37	12	6806591	6806591	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:6806591C>T	uc001qqf.1	-	3	461	c.385G>A	c.(385-387)GAC>AAC	p.D129N	C12orf53_uc001qqg.1_Missense_Mutation_p.D129N	NM_153685	NP_710152	Q8IYJ0	CL053_HUMAN	hypothetical protein LOC196500 precursor	129	Extracellular (Potential).					integral to membrane					0						AAACCATAGTCCAGAAATCCG	0.612													14	33					0	0	0.000566183	0	0
CD163L1	283316	broad.mit.edu	37	12	7528454	7528454	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:7528454G>C	uc001qsy.2	-	10	2554	c.2528C>G	c.(2527-2529)TCT>TGT	p.S843C	CD163L1_uc010sge.1_Missense_Mutation_p.S853C	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	843	SRCR 8.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CACAGAAAGAGATATGGCATC	0.458													44	27					0	0	0.000781405	0	0
CD163L1	283316	broad.mit.edu	37	12	7586219	7586219	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:7586219G>A	uc001qsy.2	-	3	222	c.196C>T	c.(196-198)CAG>TAG	p.Q66*	CD163L1_uc010sge.1_Nonsense_Mutation_p.Q66*	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	66	SRCR 1.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						CACTGTCCCTGGAATTTCACC	0.493													28	73					0	0	0.00209593	0	0
CD163	9332	broad.mit.edu	37	12	7632488	7632488	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:7632488C>T	uc001qsz.3	-	16	3576	c.3448G>A	c.(3448-3450)GAA>AAA	p.E1150K	CD163_uc001qta.3_Silent_p.*1122*|CD163_uc009zfw.2_Silent_p.*1155*	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1150	Cytoplasmic (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TTTTCCTTTTCAGTGTGGCTC	0.398													34	23					0	0	0.000692331	0	0
CD163	9332	broad.mit.edu	37	12	7639971	7639971	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:7639971G>A	uc001qsz.3	-	8	2162	c.2034C>T	c.(2032-2034)GCC>GCT	p.A678A	CD163_uc001qta.3_Silent_p.A678A|CD163_uc009zfw.2_Silent_p.A711A	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	678	SRCR 6.|Extracellular (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						AGATTACAGAGGCCACTTGCT	0.483													12	16					0	0	0.00136819	0	0
GDF3	9573	broad.mit.edu	37	12	7848199	7848199	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:7848199C>T	uc001qte.2	-	1	162	c.126G>A	c.(124-126)CAG>CAA	p.Q42Q		NM_020634	NP_065685	Q9NR23	GDF3_HUMAN	growth differentiation factor 3 precursor	42					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			skin(3)|ovary(1)|lung(1)|central_nervous_system(1)	6						GTTGGAACTTCTGGGGTGAAG	0.483													13	25					0	0	0.00185496	0	0
DPPA3	359787	broad.mit.edu	37	12	7867807	7867807	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:7867807G>A	uc001qtf.2	+	2	189	c.111G>A	c.(109-111)TTG>TTA	p.L37L		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	37						cytoplasm|nucleus					0				Kidney(36;0.0887)		CCGAGACGTTGATAAAGAACC	0.458													60	46					0	0	0.000781405	0	0
CLEC4C	170482	broad.mit.edu	37	12	7882278	7882278	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:7882278G>A	uc001qtg.1	-	6	730	c.556C>T	c.(556-558)CGT>TGT	p.R186C	CLEC4C_uc001qth.1_Missense_Mutation_p.R186C|CLEC4C_uc001qti.1_Missense_Mutation_p.R155C	NM_130441	NP_569708	Q8WTT0	CLC4C_HUMAN	C-type lectin domain family 4, member C isoform	186	Extracellular (Potential).|C-type lectin.				innate immune response	integral to membrane	sugar binding			ovary(2)|skin(1)	3				Kidney(36;0.0915)		TCTGAAGAACGGAAATTTATT	0.398													18	45					0	0	0.00074312	0	0
CLEC6A	93978	broad.mit.edu	37	12	8610512	8610512	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:8610512C>T	uc001qum.1	+	2	167	c.50C>T	c.(49-51)TCC>TTC	p.S17F		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	17	Cytoplasmic (Potential).				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					GGCTGGTTGTCCCTGAGACTC	0.488													37	18					0	0	0.000953801	0	0
A2M	2	broad.mit.edu	37	12	9248273	9248273	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:9248273C>T	uc001qvk.1	-	16	1988	c.1875G>A	c.(1873-1875)AAG>AAA	p.K625K	A2M_uc009zgk.1_Silent_p.K475K	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	625					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CAGTGAGGTCCTTTTCTGGTA	0.328													35	76					0	0	0.00128727	0	0
PZP	5858	broad.mit.edu	37	12	9353559	9353559	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:9353559C>T	uc001qvl.2	-	6	628	c.599G>A	c.(598-600)GGC>GAC	p.G200D	PZP_uc009zgl.2_Missense_Mutation_p.G69D	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						CCTGTAGGAGCCCTGAATGGG	0.483													69	29					0	0	0.000781405	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962331	10962331	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:10962331G>A	uc001qyx.2	-	1	437	c.344C>T	c.(343-345)TCG>TTG	p.S115L	TAS2R8_uc010shh.1_5'Flank	NM_023917	NP_076406	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	115	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						AAATGGGTGCGATATATTGGC	0.378													19	21					0	0	0.00121646	0	0
PRB3	5544	broad.mit.edu	37	12	11420704	11420704	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:11420704C>T	uc001qzs.2	-	3	517	c.479G>A	c.(478-480)GGA>GAA	p.G160E	PRB4_uc001qzf.1_Intron	NM_006249	NP_006240	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3	160	10 X 21 AA tandem repeats of [RH]-P-G-K- P-[EQ]-G-[PQS]-P-[PS]-Q-[GE]-G-N-[QK]- [SP]-[QR]-[GR]-P-P-P.|Pro-rich.|6.		Missing (in allele S).			extracellular region	Gram-negative bacterial cell surface binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TTCTGGCTTTCCCGGACGAGG	0.642													62	43					0	0	0.000781405	0	0
LRP6	4040	broad.mit.edu	37	12	12279653	12279653	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:12279653G>A	uc001rah.3	-	20	4426	c.4284C>T	c.(4282-4284)CAC>CAT	p.H1428H	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Silent_p.H1383H	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	1428	Cytoplasmic (Potential).				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				AAGAACTTGGGTGTGGCACAT	0.463													176	113					0	0	0.000781405	0	0
GRIN2B	2904	broad.mit.edu	37	12	13716388	13716388	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:13716388C>T	uc001rbt.2	-	13	3963	c.3784G>A	c.(3784-3786)GAA>AAA	p.E1262K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1262	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGTCCAGTTCCTGCAGGGAG	0.597													15	44					0	0	0.000308642	0	0
GRIN2B	2904	broad.mit.edu	37	12	13761666	13761666	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:13761666G>A	uc001rbt.2	-	9	2060	c.1881C>T	c.(1879-1881)ACC>ACT	p.T627T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	627	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGATCTTGGAGGTGGTCCCCT	0.522													24	26					0	0	0.00106085	0	0
GUCY2C	2984	broad.mit.edu	37	12	14839148	14839148	+	Silent	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:14839148C>A	uc001rcd.2	-	3	479	c.342G>T	c.(340-342)CGG>CGT	p.R114R	GUCY2C_uc009zhz.2_Silent_p.R114R	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	114	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						CACAGCCCATCCGTTGTGCAT	0.438													17	6					3.41278e-10	1.16517e-09	0.000566183	1	0
RERGL	79785	broad.mit.edu	37	12	18234351	18234351	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:18234351C>T	uc001rdq.2	-	6	586	c.392G>A	c.(391-393)CGA>CAA	p.R131Q	RERGL_uc001rdr.2_Missense_Mutation_p.R130Q	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	131	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						GCCAACCTCTCGCACATGACA	0.448													13	40					0	0	0.00136819	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20876032	20876032	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:20876032C>T	uc001rej.3	+	10	1385	c.1030C>T	c.(1030-1032)CCA>TCA	p.P344S	SLCO1C1_uc010sii.1_Missense_Mutation_p.P344S|SLCO1C1_uc010sij.1_Missense_Mutation_p.P295S|SLCO1C1_uc009zip.2_Missense_Mutation_p.P178S|SLCO1C1_uc001rei.2_Missense_Mutation_p.P344S|SLCO1C1_uc010sik.1_Missense_Mutation_p.P226S	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	344	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					AGATTTTCTTCCATCACTGAA	0.413													30	33					0	0	0.00209593	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21014014	21014014	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:21014014C>T	uc001rek.2	+	5	549	c.423C>T	c.(421-423)ACC>ACT	p.T141T	SLCO1B3_uc001rel.2_Silent_p.T141T|SLCO1B3_uc010sil.1_Silent_p.T141T|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_5'Flank	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	141	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					GTTTATCAACCTGTTTAATTA	0.284													31	40					0	0	0.001512	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21353449	21353449	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:21353449C>T	uc001req.3	+	9	1082	c.978C>T	c.(976-978)TTC>TTT	p.F326F		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	326	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CAGGTTTTTTCCAGTCTTTTA	0.274													9	18					0	0	0.000274275	0	0
ABCC9	10060	broad.mit.edu	37	12	21965081	21965081	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:21965081G>A	uc001rfi.1	-	34	4133	c.4113C>T	c.(4111-4113)GTC>GTT	p.V1371V	ABCC9_uc001rfh.2_Silent_p.V1371V|ABCC9_uc001rfj.1_Silent_p.V1335V	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1371	Cytoplasmic (Potential).|ABC transporter 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TCCCATCAATGACAATTTTTC	0.323													47	41					0	0	0.000781405	0	0
ABCC9	10060	broad.mit.edu	37	12	22069894	22069894	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:22069894C>T	uc001rfi.1	-	4	570	c.550G>A	c.(550-552)GAG>AAG	p.E184K	ABCC9_uc001rfh.2_Missense_Mutation_p.E184K|ABCC9_uc001rfj.1_Missense_Mutation_p.E184K	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	184	Helical; Name=5; (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ACATTGATCTCCACAGCCATC	0.413													119	150					0	0	0.000781405	0	0
TM7SF3	51768	broad.mit.edu	37	12	27127114	27127114	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:27127114A>G	uc010sjl.1	-	12	1735	c.1497T>C	c.(1495-1497)ATT>ATC	p.I499I		NM_016551	NP_057635	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3 precursor	499	Helical; (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(2)	2	Colorectal(261;0.0847)					TCTGTAACGTAATTCCACTTA	0.428													24	24					0	0	0.00047179	0	0
CCDC91	55297	broad.mit.edu	37	12	28412319	28412319	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:28412319G>A	uc001riq.2	+	2	69	c.53G>A	c.(52-54)GGA>GAA	p.G18E	CCDC91_uc001rio.2_5'UTR|CCDC91_uc009zjk.2_RNA|CCDC91_uc001rip.1_Missense_Mutation_p.G18E	NM_018318	NP_060788	Q7Z6B0	CCD91_HUMAN	GGA binding partner	18					protein transport	Golgi apparatus|membrane				central_nervous_system(1)	1	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					TTTGATGGTGGAAGTGGTGAA	0.398													26	53					0	0	0.0024448	0	0
PKP2	5318	broad.mit.edu	37	12	32945632	32945632	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:32945632G>A	uc001rlj.3	-	13	2638	c.2523C>T	c.(2521-2523)TCC>TCT	p.S841S	PKP2_uc001rlk.3_Silent_p.S797S|PKP2_uc010skj.1_Silent_p.S794S	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	841	ARM 8.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					ACAGAAGGACGGAAGCAGCTT	0.473													48	52					0	0	0.000781405	0	0
CNTN1	1272	broad.mit.edu	37	12	41463829	41463829	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:41463829G>A	uc001rmm.1	+	24	3162	c.3049G>A	c.(3049-3051)GAA>AAA	p.E1017K	CNTN1_uc001rmn.1_Missense_Mutation_p.E1006K	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	1017					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGTCTACTTGGAATTCTGAAT	0.498													30	28					0	0	0.00111076	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826135	43826135	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:43826135G>A	uc010skx.1	-	21	3068	c.3068C>T	c.(3067-3069)CCC>CTC	p.P1023L	ADAMTS20_uc001rno.1_Missense_Mutation_p.P177L|ADAMTS20_uc001rnp.1_Missense_Mutation_p.P177L	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1023	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGCCCAACTGGGACAGGAAAA	0.388													24	19					0	0	0.00278032	0	0
ARID2	196528	broad.mit.edu	37	12	46246257	46246257	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:46246257C>T	uc001ros.1	+	15	4351	c.4351C>T	c.(4351-4353)CCT>TCT	p.P1451S	ARID2_uc001ror.2_Missense_Mutation_p.P1451S|ARID2_uc009zkg.1_Missense_Mutation_p.P907S|ARID2_uc009zkh.1_Missense_Mutation_p.P1078S|ARID2_uc001rou.1_Missense_Mutation_p.P785S	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1451					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GCTTAATGGACCTCTAGCTTC	0.433													24	70					0	0	0.000720815	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48133942	48133942	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:48133942G>A	uc009zkp.2	-	22	2669	c.2229C>T	c.(2227-2229)TCC>TCT	p.S743S	uc001rpv.2_RNA|RAPGEF3_uc001rpw.2_Silent_p.S78S|RAPGEF3_uc001rpx.2_Silent_p.S200S|RAPGEF3_uc010sln.1_Silent_p.S240S|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Silent_p.S743S|RAPGEF3_uc001rpz.3_Silent_p.S785S	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	743					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		TCTCGAGGGCGGAGTACAGCT	0.667													20	9					0	0	0.000586117	0	0
C12orf54	121273	broad.mit.edu	37	12	48882737	48882737	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:48882737G>A	uc001rrr.2	+	4	223	c.166G>A	c.(166-168)GAG>AAG	p.E56K	C12orf54_uc009zky.1_RNA	NM_152319	NP_689532	Q6X4T0	CL054_HUMAN	hypothetical protein LOC121273	56											0						TATACAAAAGGAGGTGAGATT	0.368													113	177					0	0	0.000781405	0	0
DDX23	9416	broad.mit.edu	37	12	49233800	49233800	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:49233800G>A	uc001rsm.2	-	4	501	c.410C>T	c.(409-411)CCT>CTT	p.P137L		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	137	Glu-rich.			P -> L (in Ref. 1; AAB87902).		catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						CTTTACCTTAGGCTTCTTATC	0.393													150	184					0	0	0.000781405	0	0
RND1	27289	broad.mit.edu	37	12	49258632	49258632	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:49258632C>T	uc001rsn.2	-	2	245	c.142G>A	c.(142-144)GAA>AAA	p.E48K		NM_014470	NP_055285	Q92730	RND1_HUMAN	GTP-binding protein RHO6 precursor	48	Effector region (Potential).				actin filament organization|axon guidance|negative regulation of cell adhesion|neuron remodeling|small GTPase mediated signal transduction	adherens junction|cytoskeleton|cytosol	GTP binding|GTPase activity|receptor binding			ovary(1)	1						GTGTAATTTTCGAACACGGTG	0.517													48	67					0	0	0.000781405	0	0
MLL2	8085	broad.mit.edu	37	12	49440416	49440416	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:49440416G>A	uc001rta.3	-	15	4394	c.4394C>T	c.(4393-4395)CCC>CTC	p.P1465L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1465	Cys-rich.|PHD-type 4.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCGCCCTTGGGGACGGTGAG	0.562			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			96	101					0	0	0.000781405	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50188918	50188919	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:50188918_50188919CC>TT	uc009zlk.2	-	8	2926_2927	c.2724_2725GG>AA	c.(2722-2727)GAGGTC>GAAATC	p.V909I	NCKAP5L_uc001rvc.3_Missense_Mutation_p.V113I|NCKAP5L_uc001rvb.2_Missense_Mutation_p.V502I	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	905										central_nervous_system(1)	1						CGGTGCTTGACCTCGGCGCCAG	0.639													15	25					0	0	6.4e-05	0	0
FAIM2	23017	broad.mit.edu	37	12	50295080	50295080	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:50295080G>A	uc001rvj.1	-	2	189	c.44C>T	c.(43-45)ACC>ATC	p.T15I	FAIM2_uc001rvi.1_5'UTR|FAIM2_uc001rvk.1_RNA	NM_012306	NP_036438	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	15					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|ovary(1)|skin(1)	3						CTGCCCCTCGGTCCCAGGGGC	0.607													33	41					0	0	0.000814825	0	0
LASS5	91012	broad.mit.edu	37	12	50536905	50536905	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:50536905C>A	uc001rwd.3	-	3	403	c.386G>T	c.(385-387)CGG>CTG	p.R129L	LASS5_uc001rwc.2_Missense_Mutation_p.R48L|LASS5_uc001rwe.3_Missense_Mutation_p.R70L|LASS5_uc001rwf.3_RNA|LASS5_uc010smq.1_5'UTR	NM_147190	NP_671723	Q8N5B7	CERS5_HUMAN	LAG1 homolog, ceramide synthase 5	129	Cytoplasmic (Potential).|Homeobox.				ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0						CTGATTCCTCCGATGGCGAAA	0.478													9	311					1.12685e-05	3.82939e-05	0.000274275	1	0
LIMA1	51474	broad.mit.edu	37	12	50571299	50571300	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:50571299_50571300GG>TT	uc001rwj.3	-	11	2001_2002	c.1827_1828CC>AA	c.(1825-1830)TCCCCA>TCAACA	p.P610T	LIMA1_uc001rwg.3_Missense_Mutation_p.P308T|LIMA1_uc001rwh.3_Missense_Mutation_p.P449T|LIMA1_uc001rwi.3_Missense_Mutation_p.P451T|LIMA1_uc001rwk.3_Missense_Mutation_p.P611T|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	610					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						CTGATAGGTGGGGACACAGTTT	0.475													12	326					0	0	6.4e-05	0	0
SLC11A2	4891	broad.mit.edu	37	12	51382183	51382183	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:51382183G>A	uc001rxe.3	-	16	1708	c.1611C>T	c.(1609-1611)TTC>TTT	p.F537F	SLC11A2_uc001rxd.3_Silent_p.F386F|SLC11A2_uc001rxc.3_Silent_p.F537F|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_Silent_p.F150F|SLC11A2_uc010smx.1_Silent_p.F533F|SLC11A2_uc001rxh.1_Silent_p.F537F|SLC11A2_uc001rxj.1_Silent_p.F537F|SLC11A2_uc001rxi.2_Silent_p.F537F|SLC11A2_uc001rxk.1_Silent_p.F566F|SLC11A2_uc010smy.1_Silent_p.F500F	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	537	Cytoplasmic (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						CACAGTCCAGGAAGGACATGC	0.488													34	42					0	0	0.00148497	0	0
SCN8A	6334	broad.mit.edu	37	12	52174539	52174539	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:52174539G>A	uc001ryw.2	+	21	4104	c.3926G>A	c.(3925-3927)CGA>CAA	p.R1309Q	SCN8A_uc010snl.1_Intron|SCN8A_uc001rza.1_Intron	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1309	III.|Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GCCTTATCACGATTTGAAGGG	0.388													21	28					0	0	0.00047179	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284611	52284611	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:52284611C>T	uc001rzf.3	+	5	1085	c.506C>T	c.(505-507)CCC>CTC	p.P169L	ANKRD33_uc001rzh.3_3'UTR|ANKRD33_uc001rzd.2_Missense_Mutation_p.P294L|ANKRD33_uc001rze.2_Missense_Mutation_p.P190L|ANKRD33_uc001rzg.3_Missense_Mutation_p.P96L|ANKRD33_uc001rzi.3_Missense_Mutation_p.P169L	NM_001130015	NP_001123487	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33 isoform 1	169											0				BRCA - Breast invasive adenocarcinoma(357;0.0969)		TTGAGCCTCCCCTTTGCCCCG	0.562													10	9					0	0	0.000673444	0	0
NR4A1	3164	broad.mit.edu	37	12	52448684	52448684	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:52448684C>T	uc001rzs.2	+	3	886	c.572C>T	c.(571-573)TCC>TTC	p.S191F	NR4A1_uc010sno.1_Missense_Mutation_p.S204F|NR4A1_uc001rzr.2_Missense_Mutation_p.S191F|NR4A1_uc009zmb.1_Missense_Mutation_p.S191F|NR4A1_uc001rzt.2_Missense_Mutation_p.S191F|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	191					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		GCCTTCTTTTCCTTCAGTCCT	0.657													41	76					0	0	0.00170553	0	0
KRT80	144501	broad.mit.edu	37	12	52565271	52565271	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:52565271G>C	uc001rzx.2	-	9	1368	c.1270C>G	c.(1270-1272)CGA>GGA	p.R424G	KRT80_uc001rzw.2_Missense_Mutation_p.R459G|KRT80_uc001rzy.2_3'UTR	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	424	Tail.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		TTCTTCTTTCGGGAGGGGGCC	0.562													20	51					0	0	0.00188189	0	0
KRT6C	286887	broad.mit.edu	37	12	52867508	52867508	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:52867508G>A	uc001sal.3	-	1	62	c.14C>T	c.(13-15)TCC>TTC	p.S5F		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	5	Head.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GATGGTGGTGGATGTGCTGGC	0.642													16	23					0	0	0.000720815	0	0
KRT74	121391	broad.mit.edu	37	12	52963677	52963677	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:52963677C>T	uc001sap.1	-	6	1148	c.1100G>A	c.(1099-1101)AGG>AAG	p.R367K		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	367	Rod.|Coil 2.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		ACACCGGATCCTCTGGATGAG	0.602													23	58					0	0	0.00047179	0	0
KRT2	3849	broad.mit.edu	37	12	53038892	53038892	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:53038892C>T	uc001sat.2	-	9	1864	c.1831G>A	c.(1831-1833)GGA>AGA	p.G611R		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	611	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		GAGCCATATCCTCCTCCAGAG	0.542													27	79					0	0	0.000720815	0	0
KRT4	3851	broad.mit.edu	37	12	53203182	53203182	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:53203182C>T	uc001saz.2	-	4	1312	c.1041G>A	c.(1039-1041)AAG>AAA	p.K347K		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	273						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						CATAGAGGACCTTCAGGAAGT	0.532													25	65					0	0	0.001512	0	0
TENC1	23371	broad.mit.edu	37	12	53456001	53456001	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:53456001C>T	uc001sbp.2	+	23	3774	c.3639C>T	c.(3637-3639)ATC>ATT	p.I1213I	TENC1_uc001sbl.2_Silent_p.I1089I|TENC1_uc001sbn.2_Silent_p.I1223I|TENC1_uc001sbq.2_Silent_p.I611I|TENC1_uc001sbr.2_RNA|TENC1_uc009zmr.2_Silent_p.I708I|TENC1_uc001sbs.2_5'UTR	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	1213	SH2.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						GGGTGAAGATCAAGGGCTGCC	0.597													34	20					0	0	0.00111076	0	0
ITGB7	3695	broad.mit.edu	37	12	53594063	53594063	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:53594063G>A	uc009zmv.2	-	2	236	c.165C>T	c.(163-165)ATC>ATT	p.I55I	ITGB7_uc001scc.2_Silent_p.I55I|ITGB7_uc010snz.1_RNA|ITGB7_uc010soa.1_Silent_p.I55I	NM_000889	NP_000880	P26010	ITB7_HUMAN	integrin, beta 7 precursor	55	Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|breast(1)	8						GGTGTGAGAGGATGCACTTCT	0.488													12	57					0	0	0.000978159	0	0
KIAA0748	9840	broad.mit.edu	37	12	55356658	55356658	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:55356658C>T	uc001sgn.3	-	9	1134	c.1024G>A	c.(1024-1026)GAA>AAA	p.E342K	KIAA0748_uc001sgl.3_Missense_Mutation_p.E204K|KIAA0748_uc001sgm.3_Missense_Mutation_p.E89K|KIAA0748_uc010spb.1_Missense_Mutation_p.E89K|KIAA0748_uc010spc.1_Missense_Mutation_p.E204K|KIAA0748_uc010spd.1_Missense_Mutation_p.E342K|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	342										ovary(1)|central_nervous_system(1)	2						ACAGGATCTTCCTGTGAGAAT	0.488													19	14					0	0	0.000958276	0	0
OR10A7	121364	broad.mit.edu	37	12	55615186	55615186	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:55615186C>T	uc010spf.1	+	1	378	c.378C>T	c.(376-378)ATC>ATT	p.I126I		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TTGTGGCCATCTGTAACCCTC	0.463													25	55					0	0	0.00278032	0	0
OR6C65	403282	broad.mit.edu	37	12	55794521	55794521	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:55794521C>T	uc010spl.1	+	1	209	c.209C>T	c.(208-210)TCA>TTA	p.S70L		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTAGAAATTTCATTTACGACA	0.318													17	35					0	0	0.000422831	0	0
SLC39A5	283375	broad.mit.edu	37	12	56631453	56631454	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:56631453_56631454GG>AA	uc010sqj.1	+	13	1818_1819	c.1561_1562GG>AA	c.(1561-1563)GGC>AAC	p.G521N	SLC39A5_uc010sqk.1_Missense_Mutation_p.G521N	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	521	Helical; (Potential).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						GCTGGGGGGCGGCCTCATGCTT	0.653													6	28					0	0	6.4e-05	0	0
ANKRD52	283373	broad.mit.edu	37	12	56637082	56637082	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:56637082G>A	uc001skm.3	-	28	3165	c.3075C>T	c.(3073-3075)GAC>GAT	p.D1025D		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	1025							protein binding			ovary(2)	2						GACTGACGGCGTCCTTGGGTG	0.632													19	39					0	0	0.00278032	0	0
MIP	4284	broad.mit.edu	37	12	56848172	56848172	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:56848172G>A	uc001slh.2	-	1	258	c.226C>T	c.(226-228)CTT>TTT	p.L76F		NM_012064	NP_036196	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	76					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			skin(1)	1						GAGCCCACAAGGAAAGCAAAA	0.602													23	22					0	0	0.00278032	0	0
MIP	4284	broad.mit.edu	37	12	56848285	56848285	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:56848285G>A	uc001slh.2	-	1	145	c.113C>T	c.(112-114)CCC>CTC	p.P38L		NM_012064	NP_036196	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	38	Extracellular (By similarity).				response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			skin(1)	1						AACATGCAGGGGTCCAGGAGC	0.582													45	19					0	0	0.000781405	0	0
SPRYD4	283377	broad.mit.edu	37	12	56863217	56863217	+	Silent	SNP	G	A	A	rs71459371		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:56863217G>A	uc001sli.3	+	2	555	c.480G>A	c.(478-480)CAG>CAA	p.Q160Q	SPRYD4_uc010sqo.1_Silent_p.Q148Q	NM_207344	NP_997227	Q8WW59	SPRY4_HUMAN	SPRY domain containing 4	160	B30.2/SPRY.					nucleus					0						ATGAGGCCCAGAAGCTGAGCC	0.592													28	25					0	0	0.001512	0	0
LRP1	4035	broad.mit.edu	37	12	57574159	57574160	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:57574159_57574160CG>AT	uc001snd.2	+	32	5749_5750	c.5283_5284CG>AT	c.(5281-5286)TCCGGG>TCATGG	p.G1762W		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1762	Extracellular (Potential).|LDL-receptor class B 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GGATCAGCTCCGGGAACCATAC	0.619													10	175					0	0	6.4e-05	0	0
LRP1	4035	broad.mit.edu	37	12	57588878	57588878	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:57588878C>T	uc001snd.2	+	51	8768	c.8302C>T	c.(8302-8304)CAC>TAC	p.H2768Y		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	2768	Extracellular (Potential).|LDL-receptor class A 16.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGAGGCTGCTCACTGTGGTAA	0.632													86	64					0	0	0.000781405	0	0
LRP1	4035	broad.mit.edu	37	12	57598218	57598218	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:57598218C>T	uc001snd.2	+	71	11443	c.10977C>T	c.(10975-10977)TTC>TTT	p.F3659F		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3659	Extracellular (Potential).|LDL-receptor class A 29.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGGACGAGTTCCAGTGCAACA	0.612													22	44					0	0	0.00152264	0	0
LRP1	4035	broad.mit.edu	37	12	57598914	57598914	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:57598914C>T	uc001snd.2	+	73	11683	c.11217C>T	c.(11215-11217)ACC>ACT	p.T3739T		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3739	LDL-receptor class A 31.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCCACACCACCCACTGCAAAG	0.617													33	10					0	0	0.000692331	0	0
GLI1	2735	broad.mit.edu	37	12	57865042	57865042	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:57865042G>A	uc001snx.2	+	12	2597	c.2519G>A	c.(2518-2520)GGG>GAG	p.G840E	GLI1_uc009zpq.2_Missense_Mutation_p.G712E	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	840					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			CCCAGTGAGGGGCCCCCACAT	0.587													30	28					0	0	0.000692331	0	0
XRCC6BP1	91419	broad.mit.edu	37	12	58350598	58350598	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:58350598C>T	uc001sqp.2	+	6	706	c.666C>T	c.(664-666)ATC>ATT	p.I222I		NM_033276	NP_150592	Q9Y6H3	ATP23_HUMAN	XRCC6 binding protein 1	222					double-strand break repair via nonhomologous end joining	DNA-dependent protein kinase-DNA ligase 4 complex	DNA-dependent protein kinase activity|metal ion binding|metalloendopeptidase activity			ovary(1)	1						TTGGAAGGATCCCACATAACA	0.353													39	66					0	0	0.00111076	0	0
SLC16A7	9194	broad.mit.edu	37	12	60165124	60165124	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:60165124C>T	uc001sqs.2	+	4	641	c.342C>T	c.(340-342)CTC>CTT	p.L114L	SLC16A7_uc001sqt.2_Silent_p.L114L|SLC16A7_uc001squ.2_Silent_p.L114L|SLC16A7_uc009zqi.2_Silent_p.L15L|SLC16A7_uc010ssi.1_Silent_p.L15L	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	114	Extracellular (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	AGCTGTACCTCACTATGGGAT	0.423													34	112					0	0	0.00111076	0	0
SLC16A7	9194	broad.mit.edu	37	12	60168705	60168705	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:60168705A>G	uc001sqs.2	+	5	928	c.629A>G	c.(628-630)AAG>AGG	p.K210R	SLC16A7_uc001sqt.2_Missense_Mutation_p.K210R|SLC16A7_uc001squ.2_Missense_Mutation_p.K210R|SLC16A7_uc009zqi.2_Missense_Mutation_p.K111R|SLC16A7_uc010ssi.1_Missense_Mutation_p.K111R	NM_004731	NP_004722	O60669	MOT2_HUMAN	solute carrier family 16, member 7	210	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			ovary(1)	1				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	TCTAAAAATAAGACTGGCAAA	0.378													17	24					0	0	0.000422831	0	0
PPM1H	57460	broad.mit.edu	37	12	63195772	63195772	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:63195772C>T	uc001srk.3	-	3	729	c.580G>A	c.(580-582)GAG>AAG	p.E194K		NM_020700	NP_065751	Q9ULR3	PPM1H_HUMAN	protein phosphatase 1H (PP2C domain containing)	194	PP2C-like.						phosphoprotein phosphatase activity			lung(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		TCAGGCTCCTCCCCCAGGCAG	0.716													28	57					0	0	0.00209593	0	0
C12orf66	144577	broad.mit.edu	37	12	64588126	64588126	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:64588126G>A	uc001srw.3	-	3	893	c.834C>T	c.(832-834)AGC>AGT	p.S278S	C12orf66_uc009zql.2_Silent_p.S225S	NM_152440	NP_689653	Q96MD2	CL066_HUMAN	hypothetical protein LOC144577	278										ovary(1)	1						TCGTTTGTCGGCTCAGAGCCT	0.433													48	19					0	0	0.000781405	0	0
LYZ	4069	broad.mit.edu	37	12	69742288	69742288	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:69742288G>A	uc001suw.2	+	1	155	c.100G>A	c.(100-102)GGA>AGA	p.G34R		NM_000239	NP_000230	P61626	LYSC_HUMAN	lysozyme precursor	34					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding				0	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			GAAAAGATTGGGAATGGATGG	0.473													10	41					0	0	0.000978159	0	0
FRS2	10818	broad.mit.edu	37	12	69965954	69965954	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:69965954G>A	uc001suy.2	+	9	979	c.469G>A	c.(469-471)GGA>AGA	p.G157R	FRS2_uc001suz.2_Missense_Mutation_p.G157R|FRS2_uc009zrj.2_Missense_Mutation_p.G157R|FRS2_uc009zrk.2_Missense_Mutation_p.G157R	NM_006654	NP_006645	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	157					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			prostate(1)|kidney(1)	2	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TCCCTCATTTGGAGATGCTTC	0.493													21	55					0	0	0.00121646	0	0
PTPRR	5801	broad.mit.edu	37	12	71286618	71286618	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:71286618G>A	uc001swi.1	-	2	614	c.198C>T	c.(196-198)TAC>TAT	p.Y66Y		NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	66	Extracellular (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		AAGAGGAATGGTAGCTATGTC	0.453													50	123					0	0	0.000781405	0	0
ZDHHC17	23390	broad.mit.edu	37	12	77191241	77191241	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:77191241C>T	uc001syk.1	+	2	284	c.121C>T	c.(121-123)CAT>TAT	p.H41Y	ZDHHC17_uc001syi.1_RNA|ZDHHC17_uc001syj.2_Intron	NM_015336	NP_056151	Q8IUH5	ZDH17_HUMAN	huntingtin interacting protein 14	41	Cytoplasmic (Potential).				lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding				0						CCATTATAACCATGGATATGG	0.343													17	10					0	0	0.000958276	0	0
E2F7	144455	broad.mit.edu	37	12	77423987	77423987	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:77423987G>A	uc001sym.3	-	10	1744	c.1508C>T	c.(1507-1509)TCT>TTT	p.S503F	E2F7_uc009zse.2_5'UTR	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	503					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						CTGAGCAACAGAAAATACTGG	0.522													53	77					0	0	0.000781405	0	0
NAV3	89795	broad.mit.edu	37	12	78573391	78573391	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:78573391G>A	uc001syp.2	+	29	5619	c.5446G>A	c.(5446-5448)GAT>AAT	p.D1816N	NAV3_uc001syo.2_Missense_Mutation_p.D1794N|NAV3_uc010sub.1_Missense_Mutation_p.D1273N|NAV3_uc009zsf.2_Missense_Mutation_p.D625N	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1816	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.D1794Y(1)		large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AAAATTAACGGATATTCGGCT	0.463										HNSCC(70;0.22)			31	60					0	0	0.00127121	0	0
ACSS3	79611	broad.mit.edu	37	12	81472131	81472131	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:81472131G>A	uc001szl.1	+	1	323	c.232G>A	c.(232-234)GGC>AGC	p.G78S	ACSS3_uc001szm.1_Missense_Mutation_p.G78S	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	78						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GAGGTTCTGGGGCAAAGCTGC	0.627													13	27					0	0	0.00185496	0	0
DCN	1634	broad.mit.edu	37	12	91539904	91539904	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:91539904C>T	uc001tbs.2	-	7	1105	c.1011G>A	c.(1009-1011)TGG>TGA	p.W337*	DCN_uc001tbo.2_Nonsense_Mutation_p.W228*|DCN_uc001tbp.2_Nonsense_Mutation_p.W190*|DCN_uc001tbq.2_Nonsense_Mutation_p.W150*|DCN_uc001tbr.2_3'UTR|DCN_uc001tbt.2_Nonsense_Mutation_p.W337*|DCN_uc001tbu.2_Nonsense_Mutation_p.W337*	NM_133503	NP_598010	P07585	PGS2_HUMAN	decorin isoform a preproprotein	337	LRR 12.				organ morphogenesis	extracellular space				central_nervous_system(2)|ovary(1)|lung(1)	4						GCTGTATCTCCCAGTACTGGA	0.463													28	59					0	0	0.0024448	0	0
FGD6	55785	broad.mit.edu	37	12	95603750	95603750	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:95603750G>A	uc001tdp.3	-	2	1534	c.1310C>T	c.(1309-1311)TCG>TTG	p.S437L	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	437					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						CACAGCAAGCGACATACTAGA	0.393													29	76					0	0	0.000878237	0	0
FGD6	55785	broad.mit.edu	37	12	95604944	95604944	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:95604944G>A	uc001tdp.3	-	2	340	c.116C>T	c.(115-117)TCT>TTT	p.S39F	FGD6_uc009zsx.2_Intron	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	39					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						TGGAACACTAGAAATCACAAT	0.483													127	86					0	0	0.000781405	0	0
DEPDC4	120863	broad.mit.edu	37	12	100657659	100657659	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:100657659G>A	uc001thi.2	-	2	173	c.170C>T	c.(169-171)CCT>CTT	p.P57L	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Intron|DEPDC4_uc009ztv.1_Missense_Mutation_p.P57L|DEPDC4_uc001thk.1_Intron|DEPDC4_uc001thl.1_Intron	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	57					intracellular signal transduction						0						AGCTTGAAAAGGACCAGAGCA	0.338													27	23					0	0	0.00178596	0	0
SLC17A8	246213	broad.mit.edu	37	12	100806590	100806590	+	Missense_Mutation	SNP	C	T	T	rs77232189		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:100806590C>T	uc010svi.1	+	10	1542	c.1229C>T	c.(1228-1230)TCG>TTG	p.S410L	SLC17A8_uc009ztx.2_Missense_Mutation_p.S360L	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	410	Helical; (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						GTTGGCTTTTCGCATACCAAA	0.448													70	52					0	0	0.000781405	0	0
ANO4	121601	broad.mit.edu	37	12	101413856	101413856	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:101413856G>A	uc010svm.1	+	9	1351	c.779G>A	c.(778-780)AGA>AAA	p.R260K	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.R225K|ANO4_uc001thx.2_Missense_Mutation_p.R260K	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	260	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						AATGCCACAAGAAGTAGAATC	0.308										HNSCC(74;0.22)			49	42					0	0	0.000781405	0	0
STAB2	55576	broad.mit.edu	37	12	104048373	104048373	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:104048373A>T	uc001tjw.2	+	13	1634	c.1448A>T	c.(1447-1449)AAG>ATG	p.K483M		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	483	Extracellular (Potential).|FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GGCAAAAAGAAGGTAAAAATT	0.323													32	19					0	0	0.000692331	0	0
STAB2	55576	broad.mit.edu	37	12	104099426	104099426	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:104099426G>T	uc001tjw.2	+	37	4103	c.3917G>T	c.(3916-3918)AGA>ATA	p.R1306I		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1306	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GAGAAGAGGAGATGCATCTAT	0.413													18	17					1.33834e-09	4.56732e-09	0.000958276	1	0
TXNRD1	7296	broad.mit.edu	37	12	104713318	104713318	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:104713318C>T	uc010swk.1	+	9	966	c.944C>T	c.(943-945)CCA>CTA	p.P315L	TXNRD1_uc010swl.1_Missense_Mutation_p.P165L|TXNRD1_uc010swm.1_Missense_Mutation_p.P217L|TXNRD1_uc010swn.1_Missense_Mutation_p.P165L|TXNRD1_uc010swo.1_Missense_Mutation_p.P165L|TXNRD1_uc010swp.1_Missense_Mutation_p.P127L|TXNRD1_uc010swq.1_Missense_Mutation_p.P215L|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Missense_Mutation_p.P231L	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	315					cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GGTGAAAGACCACGTTACTTG	0.388													8	7					0	0	0.000673444	0	0
KIAA1033	23325	broad.mit.edu	37	12	105514922	105514922	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:105514922C>T	uc001tld.2	+	9	692	c.605C>T	c.(604-606)ACC>ATC	p.T202I	KIAA1033_uc010swr.1_Missense_Mutation_p.T202I|KIAA1033_uc010sws.1_Missense_Mutation_p.T14I	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	202					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						GTTTTGCTCACCCTGGATGAA	0.328													7	41					0	0	0.000442599	0	0
POLR3B	55703	broad.mit.edu	37	12	106824229	106824229	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:106824229C>G	uc001tlp.2	+	14	1664	c.1442C>G	c.(1441-1443)CCT>CGT	p.P481R	POLR3B_uc001tlq.2_Missense_Mutation_p.P423R	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	481					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						ATGCTGTGTCCTTCGGACACT	0.527													16	44					0	0	0.00074312	0	0
WSCD2	9671	broad.mit.edu	37	12	108604066	108604066	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:108604066G>A	uc001tms.2	+	4	1410	c.666G>A	c.(664-666)CAG>CAA	p.Q222Q	WSCD2_uc001tmt.2_Silent_p.Q222Q	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	222						integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						AGCTGGCCCAGGAGTCGGCCC	0.672													3	4					0	0	0.00024832	0	0
CMKLR1	1240	broad.mit.edu	37	12	108685743	108685743	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:108685743G>A	uc009zuw.2	-	3	1188	c.997C>T	c.(997-999)CGC>TGC	p.R333C	CMKLR1_uc001tmw.2_Missense_Mutation_p.R333C|CMKLR1_uc001tmv.2_Missense_Mutation_p.R331C|CMKLR1_uc009zuv.2_Missense_Mutation_p.R333C	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	333	Cytoplasmic (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity	p.R331G(1)		lung(3)|ovary(1)|pancreas(1)	5						TTGACCAGGCGAGAGAAGAGG	0.488													29	31					0	0	0.00127121	0	0
SART3	9733	broad.mit.edu	37	12	108939021	108939021	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:108939021G>A	uc001tmz.1	-	4	858	c.623C>T	c.(622-624)TCC>TTC	p.S208F	SART3_uc009zux.1_5'UTR|SART3_uc010swx.1_Missense_Mutation_p.S208F|SART3_uc010swy.1_Missense_Mutation_p.S76F|SART3_uc010swz.1_Missense_Mutation_p.S208F|SART3_uc001tna.1_RNA	NM_014706	NP_055521	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T	208	HAT 3.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			pancreas(1)	1						TTCAAACACGGAGCGAACTTT	0.468									Porokeratosis				44	40					0	0	0.00285205	0	0
SSH1	54434	broad.mit.edu	37	12	109182671	109182672	+	Missense_Mutation	DNP	GG	TT	TT	rs141317554		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:109182671_109182672GG>TT	uc001tnm.2	-	15	2329_2330	c.2242_2243CC>AA	c.(2242-2244)CCA>AAA	p.P748K	SSH1_uc001tnl.2_Missense_Mutation_p.P436K	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	748					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						CAGGACTTTTGGGGTCTCTCTG	0.545													7	114					0	0	6.4e-05	0	0
ACACB	32	broad.mit.edu	37	12	109692107	109692107	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:109692107C>T	uc001tob.2	+	44	6253	c.6134C>T	c.(6133-6135)CCC>CTC	p.P2045L	ACACB_uc001toc.2_Missense_Mutation_p.P2045L|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Missense_Mutation_p.P711L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	2045	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CCCTACGACCCCCGGTGGATG	0.493													75	62					0	0	0.000781405	0	0
UBE3B	89910	broad.mit.edu	37	12	109936079	109936079	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:109936079C>T	uc001top.2	+	11	1464	c.861C>T	c.(859-861)TTC>TTT	p.F287F	UBE3B_uc001toq.2_Silent_p.F287F|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.F287F	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	287					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TTCGTAAATTCATCATATTTT	0.418													56	111					0	0	0.000781405	0	0
CUX2	23316	broad.mit.edu	37	12	111652089	111652089	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:111652089G>A	uc001tsa.1	+	2	302	c.149G>A	c.(148-150)CGG>CAG	p.R50Q	CUX2_uc001tsb.1_Missense_Mutation_p.R105Q	NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	50						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						GAACTCCGCCGGGAATTTAAG	0.378													55	23					0	0	0.000781405	0	0
C12orf51	283450	broad.mit.edu	37	12	112688077	112688077	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:112688077G>A	uc009zwc.2	-	18	2573	c.2555C>T	c.(2554-2556)CCC>CTC	p.P852L	C12orf51_uc010syk.1_Missense_Mutation_p.P674L|C12orf51_uc001tts.2_Missense_Mutation_p.P665L|C12orf51_uc001ttt.3_Missense_Mutation_p.P663L	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GACATCAGAGGGGTAGGTGAA	0.547													54	41					0	0	0.000781405	0	0
RPH3A	22895	broad.mit.edu	37	12	113303295	113303295	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:113303295G>A	uc010syl.1	+	6	669	c.307G>A	c.(307-309)GAA>AAA	p.E103K	RPH3A_uc001ttz.2_Missense_Mutation_p.E103K|RPH3A_uc001tty.2_Missense_Mutation_p.E99K|RPH3A_uc009zwe.1_Missense_Mutation_p.E99K|RPH3A_uc010sym.1_Missense_Mutation_p.E54K|RPH3A_uc001tua.2_5'Flank	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	103	RabBD.|FYVE-type.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ACTGTGTGGAGAACAGCTGGG	0.532													47	28					0	0	0.000781405	0	0
PLBD2	196463	broad.mit.edu	37	12	113824828	113824829	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:113824828_113824829GG>AA	uc001tve.2	+	10	1408_1409	c.1373_1374GG>AA	c.(1372-1374)CGG>CAA	p.R458Q	PLBD2_uc001tvf.2_Missense_Mutation_p.R426Q	NM_173542	NP_775813	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2 isoform 1	458					lipid catabolic process	lysosomal lumen	hydrolase activity				0						GGGAGCCCCCGGGCCCAGATCT	0.609													39	41					0	0	6.4e-05	0	0
RBM19	9904	broad.mit.edu	37	12	114395671	114395671	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:114395671G>A	uc009zwi.2	-	6	900	c.756C>T	c.(754-756)GTC>GTT	p.V252V	RBM19_uc001tvn.3_Silent_p.V252V|RBM19_uc001tvm.2_Silent_p.V252V	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	252					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TTTCCTGCAGGACTGGGGTGG	0.597													53	49					0	0	0.000781405	0	0
NOS1	4842	broad.mit.edu	37	12	117681136	117681136	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:117681136G>A	uc001twm.1	-	19	3614	c.2928C>T	c.(2926-2928)CTC>CTT	p.L976L		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	976					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCACAAAGGTGAGGCGGAACT	0.517													19	55					0	0	0.00229938	0	0
SUDS3	64426	broad.mit.edu	37	12	118827739	118827739	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:118827739C>T	uc001twz.2	+	5	487	c.348C>T	c.(346-348)TTC>TTT	p.F116F		NM_022491	NP_071936	Q9H7L9	SDS3_HUMAN	suppressor of defective silencing 3	116	Potential.				chromatin modification|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	Sin3 complex	histone deacetylase binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGAACTCTTCCTCCAGCTGG	0.448													18	24					0	0	0.000566183	0	0
SRRM4	84530	broad.mit.edu	37	12	119540140	119540140	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:119540140G>A	uc001txa.1	+	2	523	c.231G>A	c.(229-231)TGG>TGA	p.W77*		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	77					cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						CCAACAGTTGGGAGAGAGACA	0.552													11	10					0	0	0.000673444	0	0
CCDC60	160777	broad.mit.edu	37	12	119909887	119909887	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:119909887C>T	uc001txe.2	+	3	724	c.259C>T	c.(259-261)CAG>TAG	p.Q87*	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	87	Potential.									ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		ACAACAACTTCAGAAACTGAA	0.428													50	100					0	0	0.000781405	0	0
GCN1L1	10985	broad.mit.edu	37	12	120586048	120586048	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:120586048G>A	uc001txo.2	-	37	4662	c.4649C>T	c.(4648-4650)TCC>TTC	p.S1550F		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1550	HEAT 9.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTTGACATGGGAGTCGGTCAG	0.582													34	21					0	0	0.00128727	0	0
CABP1	9478	broad.mit.edu	37	12	121098548	121098548	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:121098548G>A	uc001tyu.2	+	4	911	c.844G>A	c.(844-846)GAT>AAT	p.D282N	CABP1_uc001tyv.2_Missense_Mutation_p.D139N|CABP1_uc001tyw.2_Missense_Mutation_p.D79N|CABP1_uc001tyx.2_Missense_Mutation_p.D124N	NM_001033677	NP_001028849	Q9NZU7	CABP1_HUMAN	calcium binding protein 1 isoform 3	282	EF-hand 2.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGGCCATGTAGATTTTGATGA	0.502													84	239					0	0	0.000781405	0	0
UNC119B	84747	broad.mit.edu	37	12	121151120	121151120	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:121151120C>T	uc001tyz.2	+	2	735	c.288C>T	c.(286-288)TTC>TTT	p.F96F		NM_001080533	NP_001074002	A6NIH7	U119B_HUMAN	unc-119 homolog B	96										haematopoietic_and_lymphoid_tissue(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GTATTGATTTCACCCGCTTCA	0.393													146	288					0	0	0.000781405	0	0
P2RX7	5027	broad.mit.edu	37	12	121622587	121622587	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:121622587C>T	uc001tzm.2	+	13	1866	c.1770C>T	c.(1768-1770)GGC>GGT	p.G590G	P2RX7_uc001tzn.2_Silent_p.G500G|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_Silent_p.G301G|P2RX7_uc001tzq.2_Silent_p.G420G	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	590						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGTACAGTGGCTTCAAGAGTC	0.338													16	56					0	0	0.000308642	0	0
KDM2B	84678	broad.mit.edu	37	12	121932437	121932437	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:121932437G>A	uc001uat.2	-	12	1783	c.1679C>T	c.(1678-1680)CCT>CTT	p.P560L	KDM2B_uc001uar.2_Missense_Mutation_p.P151L|KDM2B_uc001uas.2_Missense_Mutation_p.P529L|KDM2B_uc001uau.2_Missense_Mutation_p.P443L|KDM2B_uc001uav.3_Missense_Mutation_p.P470L	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	560					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						GGCCAGACTAGGGTCATCATC	0.582											OREG0022202	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	11					0	0	0.000157383	0	0
KDM2B	84678	broad.mit.edu	37	12	121972449	121972449	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:121972449C>A	uc001uat.2	-	7	834	c.730G>T	c.(730-732)GAC>TAC	p.D244Y	KDM2B_uc001uas.2_Missense_Mutation_p.D213Y|KDM2B_uc001uau.2_Missense_Mutation_p.D127Y|KDM2B_uc001uav.3_Missense_Mutation_p.D244Y	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	244	JmjC.	Iron; catalytic (By similarity).			embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CCTCCAAAGTCGATGTGGAAG	0.478													43	36					4.64027e-19	1.59368e-18	0.000781405	1	0
LRRC43	254050	broad.mit.edu	37	12	122669284	122669284	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:122669284C>T	uc009zxm.2	+	2	394	c.369C>T	c.(367-369)TTC>TTT	p.F123F	LRRC43_uc001ubw.3_5'UTR|LRRC43_uc009zxl.1_RNA	NM_001098519	NP_001091989	Q8N309	LRC43_HUMAN	leucine rich repeat containing 43 isoform 1	123											0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000312)|Epithelial(86;0.000539)|BRCA - Breast invasive adenocarcinoma(302;0.225)		CAGACACCTTCTTCTACTCCT	0.572													6	12					0	0	0.00116845	0	0
TCTN2	79867	broad.mit.edu	37	12	124191312	124191312	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:124191312C>T	uc001ufp.2	+	16	1937	c.1809C>T	c.(1807-1809)ACC>ACT	p.T603T	TCTN2_uc009zya.2_Silent_p.T602T	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	603	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		GTGGGCTTACCTGTGAGCACA	0.502													42	30					0	0	0.00285205	0	0
DNAH10	196385	broad.mit.edu	37	12	124270395	124270395	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:124270395G>A	uc001uft.3	+	9	1175	c.1150G>A	c.(1150-1152)GAC>AAC	p.D384N		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	384	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTACAACAAAGACGAGAGGAT	0.562													47	29					0	0	0.000781405	0	0
DNAH10	196385	broad.mit.edu	37	12	124335607	124335607	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:124335607G>A	uc001uft.3	+	34	5946	c.5921G>A	c.(5920-5922)GGC>GAC	p.G1974D		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1974	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TTCTCTGAGGGCTTCCTGGAG	0.642													15	36					0	0	0.000566183	0	0
DNAH10	196385	broad.mit.edu	37	12	124393903	124393903	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:124393903G>A	uc001uft.3	+	57	9582	c.9557G>A	c.(9556-9558)GGC>GAC	p.G3186D		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3186	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACAGCCAAGGGCGTGATGTCC	0.507													6	15					0	0	0.00116845	0	0
FZD10	11211	broad.mit.edu	37	12	130648351	130648351	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:130648351C>T	uc001uii.2	+	1	1320	c.864C>T	c.(862-864)ATC>ATT	p.I288I	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	288	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CCGAGAGCATCGCCTGCGACC	0.642													46	36					0	0	0.000781405	0	0
GPR133	283383	broad.mit.edu	37	12	131487747	131487747	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:131487747G>A	uc001uit.3	+	10	1603	c.1044G>A	c.(1042-1044)CTG>CTA	p.L348L	GPR133_uc010tbm.1_Silent_p.L380L	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	348	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCGTGGTACTGAGTCTCATCG	0.602													52	117					0	0	0.000781405	0	0
SFRS8	6433	broad.mit.edu	37	12	132209997	132209997	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:132209997C>T	uc001uja.1	+	5	794	c.654C>T	c.(652-654)TTC>TTT	p.F218F	SFRS8_uc010tbn.1_Silent_p.F218F|SFRS8_uc001ujb.1_Silent_p.F11F|SFRS8_uc001uiz.1_Silent_p.F92F	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	218	SURP motif 1.				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		CGGCCAGCTTCGTGTGCAGGC	0.562													15	46					0	0	0.00121646	0	0
GALNT9	50614	broad.mit.edu	37	12	132683748	132683748	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:132683748G>A	uc001ukc.3	-	9	1584	c.1468C>T	c.(1468-1470)CTC>TTC	p.L490F	GALNT9_uc009zyr.2_Missense_Mutation_p.L264F|GALNT9_uc001ukb.2_Missense_Mutation_p.L347F|GALNT9_uc001uka.2_Missense_Mutation_p.L124F	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	490	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		CAGGGGTAGAGGATCGCCCGG	0.647													7	37					0	0	0.000673444	0	0
ZNF268	10795	broad.mit.edu	37	12	133764608	133764608	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:133764608C>T	uc010tcf.1	+	3	514	c.184C>T	c.(184-186)CTA>TTA	p.L62L	ZNF268_uc010tbv.1_5'UTR|ZNF268_uc010tbw.1_5'UTR|ZNF268_uc010tbx.1_Intron|ZNF268_uc010tby.1_Intron|ZNF268_uc010tbz.1_5'UTR|ZNF268_uc010tca.1_Intron|ZNF268_uc010tcb.1_5'UTR|ZNF268_uc010tcc.1_Intron|ZNF268_uc010tcd.1_5'UTR|ZNF268_uc010tce.1_Intron|ZNF268_uc010tcg.1_5'UTR|ZNF268_uc010tch.1_Silent_p.L62L	NM_003415	NP_003406	Q14587	ZN268_HUMAN	zinc finger protein 268 isoform a	62						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AGAGAAAGTCCTAGAGTGGCT	0.463													5	4					0	0	0.00198382	0	0
LOC284232	284232	broad.mit.edu	37	13	19412846	19412846	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:19412846C>T	uc010tcj.1	-	1		c.33264G>A				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						TGTCATTTTTCATTATGCATA	0.294													32	72					0	0	0.00178596	0	0
LOC284232	284232	broad.mit.edu	37	13	19428889	19428889	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:19428889G>A	uc010tcj.1	-	1		c.17221C>T				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						TCCAACAAATGACTTTTTAAA	0.199													13	38					0	0	0.00185496	0	0
TPTE2	93492	broad.mit.edu	37	13	20025334	20025334	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:20025334C>T	uc001umd.2	-	12	984	c.773G>A	c.(772-774)CGA>CAA	p.R258Q	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.R147Q|TPTE2_uc001ume.2_Missense_Mutation_p.R181Q|TPTE2_uc009zzm.2_Intron|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	258	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		ATAGTGGTTTCGATGTTTCTT	0.363													25	22					0	0	0.001512	0	0
SPATA13	221178	broad.mit.edu	37	13	24874551	24874551	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:24874551C>T	uc001upg.1	+	11	2128	c.1721C>T	c.(1720-1722)TCA>TTA	p.S574L	SPATA13_uc001upd.1_Missense_Mutation_p.S1199L|C1QTNF9_uc001upe.2_RNA|SPATA13_uc010tcy.1_Missense_Mutation_p.S520L|SPATA13_uc010tcz.1_Missense_Mutation_p.S458L|SPATA13_uc010tda.1_Missense_Mutation_p.S518L|SPATA13_uc001uph.2_Missense_Mutation_p.S496L|SPATA13_uc010tdb.1_Missense_Mutation_p.S434L|SPATA13_uc009zzz.1_Silent_p.F131F|SPATA13_uc001upi.1_Missense_Mutation_p.S80L	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	574	C-terminal tail.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		ATGGAAATTTCAGAAAACCAG	0.368													15	22					0	0	0.00121646	0	0
ATP12A	479	broad.mit.edu	37	13	25284612	25284612	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:25284612G>A	uc001upp.2	+	20	2965	c.2778G>A	c.(2776-2778)AGG>AGA	p.R926R	ATP12A_uc010aaa.2_Silent_p.R932R	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	926	Lumenal (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGTACCAGAGGGAATACCTAG	0.348													7	50					0	0	0.000157383	0	0
RNF17	56163	broad.mit.edu	37	13	25362263	25362263	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:25362263C>T	uc001upr.2	+	7	790	c.749C>T	c.(748-750)TCG>TTG	p.S250L	RNF17_uc010tdd.1_Missense_Mutation_p.S109L|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.S250L|RNF17_uc001ups.2_Missense_Mutation_p.S189L|RNF17_uc001upq.1_Missense_Mutation_p.S250L	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	250					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTACAATTATCGCCTTCTCTA	0.299													17	37					0	0	0.00121646	0	0
RNF17	56163	broad.mit.edu	37	13	25370433	25370433	+	Missense_Mutation	SNP	G	A	A	rs9581180		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:25370433G>A	uc001upr.2	+	11	1440	c.1399G>A	c.(1399-1401)GGT>AGT	p.G467S	RNF17_uc010tdd.1_Missense_Mutation_p.G326S|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.G467S|RNF17_uc001ups.2_Missense_Mutation_p.G406S|RNF17_uc001upq.1_3'UTR	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	467					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TTTGGAACTAGGTAATGAAAT	0.299													46	26					0	0	0.000781405	0	0
RNF17	56163	broad.mit.edu	37	13	25444865	25444865	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:25444865G>A	uc001upr.2	+	32	4476	c.4435G>A	c.(4435-4437)GAT>AAT	p.D1479N	RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Missense_Mutation_p.D1475N|RNF17_uc001ups.2_Missense_Mutation_p.D1418N|RNF17_uc010aac.2_Missense_Mutation_p.D671N|RNF17_uc010aad.2_Missense_Mutation_p.D489N	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1479	Tudor 4.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TCCTCTGACGGATTTTAGAAC	0.418													8	13					0	0	0.000157383	0	0
CENPJ	55835	broad.mit.edu	37	13	25479569	25479569	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:25479569G>A	uc001upt.3	-	7	2860	c.2607C>T	c.(2605-2607)TTC>TTT	p.F869F	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA|CENPJ_uc001upu.2_5'Flank	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	869					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		AAGAAGGAAAGAATTTCATCA	0.423													48	27					0	0	0.000781405	0	0
PABPC3	5042	broad.mit.edu	37	13	25670872	25670872	+	Missense_Mutation	SNP	G	A	A	rs139042913	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:25670872G>A	uc001upy.2	+	1	597	c.536G>A	c.(535-537)CGA>CAA	p.R179Q		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	179					mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		CGTAAAGAACGAGAAGCTGAA	0.413													8	36					0	0	0.000274275	0	0
FLT3	2322	broad.mit.edu	37	13	28589333	28589333	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:28589333C>A	uc001urw.2	-	22	2796	c.2714G>T	c.(2713-2715)GGA>GTA	p.G905V	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.G864V	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	905	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.G885fs*4(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CATTTTAAATCCATTTTGAAT	0.373			Mis|O		AML|ALL								7	4					8.12818e-05	0.000275641	0.00198382	1	0
FLT1	2321	broad.mit.edu	37	13	28919595	28919595	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:28919595C>T	uc001usb.3	-	16	2627	c.2342G>A	c.(2341-2343)CGA>CAA	p.R781Q	FLT1_uc001usa.3_5'UTR	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	781	Cytoplasmic (Potential).		R -> Q (in a glioma low grade oligodendroglioma sample; somatic mutation).		cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity	p.R781Q(1)		lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TTTCATTTTTCGGATAAAGAG	0.423													4	15					0	0	0.00024832	0	0
SLC46A3	283537	broad.mit.edu	37	13	29287225	29287225	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:29287225G>A	uc001usi.2	-	2	1622	c.652C>T	c.(652-654)CTC>TTC	p.L218F	SLC46A3_uc001usg.2_Missense_Mutation_p.L143F|SLC46A3_uc001usj.2_Missense_Mutation_p.L218F|SLC46A3_uc001ush.2_Missense_Mutation_p.L218F|SLC46A3_uc001usk.2_Missense_Mutation_p.L143F	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	218	Helical; (Potential).				transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		GGATCTCCGAGAAAAAATAAA	0.338													24	20					0	0	0.00047179	0	0
MTUS2	23281	broad.mit.edu	37	13	29599316	29599316	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:29599316G>A	uc001usl.3	+	1	569	c.511G>A	c.(511-513)GAT>AAT	p.D171N		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	161						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						TGTTCCCAAGGATAAACTGGC	0.517													25	58					0	0	0.00106085	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33016764	33016764	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:33016764G>A	uc010abe.1	-	7	1932	c.1910C>T	c.(1909-1911)TCT>TTT	p.S637F	N4BP2L2_uc001uug.2_Missense_Mutation_p.S520F|N4BP2L2_uc010abd.1_Missense_Mutation_p.S550F|N4BP2L2_uc001uuh.2_Missense_Mutation_p.S468F|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.S622F	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		AATTTCTGGAGAAATAAACCC	0.333													32	15					0	0	0.0024448	0	0
NBEA	26960	broad.mit.edu	37	13	35619500	35619500	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:35619500C>T	uc001uvb.2	+	5	891	c.685C>T	c.(685-687)CCT>TCT	p.P229S		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	229						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GAGACACGGTCCTGATACTTT	0.294													18	11					0	0	0.00188189	0	0
CCNA1	8900	broad.mit.edu	37	13	37014123	37014123	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:37014123G>A	uc001uvr.3	+	6	1251	c.901G>A	c.(901-903)GAA>AAA	p.E301K	CCNA1_uc010teo.1_Missense_Mutation_p.E257K|CCNA1_uc010abq.2_Missense_Mutation_p.E257K|CCNA1_uc010abp.2_Missense_Mutation_p.E257K|CCNA1_uc001uvs.3_Missense_Mutation_p.E300K|CCNA1_uc010abr.2_Intron	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	301					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		CAGGAAATATGAAGAGATATA	0.418													17	12					0	0	0.00074312	0	0
CCNA1	8900	broad.mit.edu	37	13	37016374	37016374	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:37016374C>T	uc001uvr.3	+	8	1629	c.1279C>T	c.(1279-1281)CAT>TAT	p.H427Y	CCNA1_uc010teo.1_Missense_Mutation_p.H383Y|CCNA1_uc010abq.2_Missense_Mutation_p.H383Y|CCNA1_uc010abp.2_Missense_Mutation_p.H383Y|CCNA1_uc001uvs.3_Missense_Mutation_p.H426Y|CCNA1_uc010abr.2_RNA	NM_003914	NP_003905	P78396	CCNA1_HUMAN	cyclin A1 isoform a	427					cell division|G2/M transition of mitotic cell cycle|male meiosis I|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|spermatogenesis	cytosol|microtubule cytoskeleton|nucleoplasm	protein kinase binding			lung(2)|skin(2)|ovary(1)	5		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.91e-07)|Epithelial(112;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0119)|GBM - Glioblastoma multiforme(144;0.0242)		GAGTGAGCTTCATAAAGCGTA	0.398													48	22					0	0	0.000781405	0	0
POSTN	10631	broad.mit.edu	37	13	38154780	38154780	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:38154780C>G	uc001uwo.3	-	11	1565	c.1447G>C	c.(1447-1449)GGT>CGT	p.G483R	POSTN_uc010tet.1_Missense_Mutation_p.G11R|POSTN_uc001uwp.3_Missense_Mutation_p.G483R|POSTN_uc001uwr.2_Missense_Mutation_p.G483R|POSTN_uc001uwq.2_Missense_Mutation_p.G483R|POSTN_uc010teu.1_Missense_Mutation_p.G483R|POSTN_uc010tev.1_Missense_Mutation_p.G483R|POSTN_uc010tew.1_Missense_Mutation_p.G483R|POSTN_uc010tex.1_Missense_Mutation_p.G398R	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	483	FAS1 3.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		TGAATCGCACCGTTTCTCCCT	0.433													3	124					0	0	6.4e-05	0	0
TRPC4	7223	broad.mit.edu	37	13	38237701	38237701	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:38237701G>A	uc001uws.2	-	6	1775	c.1540C>T	c.(1540-1542)CTG>TTG	p.L514L	TRPC4_uc010abv.2_Silent_p.L94L|TRPC4_uc001uwt.2_Silent_p.L514L|TRPC4_uc010tey.1_Silent_p.L514L|TRPC4_uc010abw.2_Silent_p.L341L|TRPC4_uc010abx.2_Silent_p.L514L|TRPC4_uc010aby.2_Silent_p.L514L	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	514	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AAAATGTCCAGGAGCATTCTT	0.388													25	11					0	0	0.000586117	0	0
FREM2	341640	broad.mit.edu	37	13	39452383	39452383	+	Silent	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:39452383C>A	uc001uwv.2	+	22	9093	c.8784C>A	c.(8782-8784)CCC>CCA	p.P2928P		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2928	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCTATGTTCCCAAGTATAGTC	0.428													6	59					0.00198382	0.00668814	0.00198382	1	0
LHFP	10186	broad.mit.edu	37	13	39918104	39918104	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:39918104G>A	uc001uxf.2	-	4	1083	c.572C>T	c.(571-573)TCG>TTG	p.S191L		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	191						integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		TTTCTTGCCCGAAAAGCAAGC	0.557			T	HMGA2	lipoma								25	63					0	0	0.000720815	0	0
TNFSF11	8600	broad.mit.edu	37	13	43181040	43181040	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:43181040C>T	uc001uyu.2	+	5	1089	c.940C>T	c.(940-942)CGA>TGA	p.R314*	TNFSF11_uc001uyt.2_Nonsense_Mutation_p.R241*	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	314	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TTTTAAAGTTCGAGATATAGA	0.408													20	56					0	0	0.00121646	0	0
SETDB2	83852	broad.mit.edu	37	13	50062521	50062521	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:50062521C>T	uc001vcz.2	+	13	2614	c.1708C>T	c.(1708-1710)CCA>TCA	p.P570S	SETDB2_uc010adh.2_3'UTR|SETDB2_uc001vda.2_Missense_Mutation_p.P558S	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	570	SET.				cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		AGAAACTCCACCAAGGAGCAG	0.378													37	66					0	0	0.00148497	0	0
KCNRG	283518	broad.mit.edu	37	13	50589959	50589959	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:50589959G>A	uc001vdu.2	+	1	570	c.330G>A	c.(328-330)GTG>GTA	p.V110V	DLEU2_uc001vdn.1_Intron|DLEU2_uc001vdo.1_Intron|KCNRG_uc001vdt.2_Silent_p.V110V|TRIM13_uc001vdp.1_3'UTR|TRIM13_uc001vdq.1_3'UTR|TRIM13_uc001vdr.1_3'UTR|TRIM13_uc001vds.1_3'UTR	NM_173605	NP_775876	Q8N5I3	KCNRG_HUMAN	potassium channel regulator isoform 1	110						voltage-gated potassium channel complex	identical protein binding|voltage-gated potassium channel activity				0		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.48e-10)|COAD - Colon adenocarcinoma(199;0.204)		CTGCTCTTGTGGAGGTACATT	0.438													75	56					0	0	0.000781405	0	0
PCDH20	64881	broad.mit.edu	37	13	61986455	61986455	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:61986455C>T	uc001vid.3	-	2	2141	c.1777G>A	c.(1777-1779)GTT>ATT	p.V593I	PCDH20_uc010thj.1_Missense_Mutation_p.V593I	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	566	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TGAGTAGAAACTGTCAGAATT	0.473													46	29					0	0	0.000781405	0	0
FBXL3	26224	broad.mit.edu	37	13	77581760	77581760	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:77581760G>A	uc001vkd.2	-	5	1178	c.807C>T	c.(805-807)TTC>TTT	p.F269F		NM_012158	NP_036290	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	269					regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		GAATAGTATGGAAGTGTGTCT	0.373													25	24					0	0	0.00106085	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368978	86368978	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:86368978C>T	uc001vll.1	-	2	2125	c.1666G>A	c.(1666-1668)GAA>AAA	p.E556K	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	556	LRRCT 2.|Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GCTTTCAATTCCTTTTTGTCG	0.453													38	30					0	0	0.00148497	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369483	86369483	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:86369483G>A	uc001vll.1	-	2	1620	c.1161C>T	c.(1159-1161)TTC>TTT	p.F387F	SLITRK6_uc010afe.1_Intron	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	387	Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TTTCCAAAGTGAAATATTCCA	0.363													38	18					0	0	0.000814825	0	0
DZIP1	22873	broad.mit.edu	37	13	96239907	96239907	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:96239907G>A	uc001vmk.2	-	20	2956	c.2104C>T	c.(2104-2106)CCT>TCT	p.P702S	DZIP1_uc001vmi.2_5'UTR|DZIP1_uc001vmj.2_Missense_Mutation_p.P178S|DZIP1_uc001vml.2_Missense_Mutation_p.P683S	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	702					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			GGCGGCACAGGAAGTGGGCCT	0.562													19	40					0	0	0.00278032	0	0
IPO5	3843	broad.mit.edu	37	13	98658486	98658486	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:98658486T>A	uc001vnf.1	+	14	1665	c.1600T>A	c.(1600-1602)TTT>ATT	p.F534I	IPO5_uc001vne.2_Missense_Mutation_p.F552I|IPO5_uc010tik.1_Missense_Mutation_p.F409I|IPO5_uc010til.1_Missense_Mutation_p.F474I|IPO5_uc001vng.1_Missense_Mutation_p.F155I	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	534					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						CTATGATTTATTTATGCCATC	0.403													59	64					0	0	0.000781405	0	0
RNF113B	140432	broad.mit.edu	37	13	98829361	98829361	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:98829361C>T	uc001vnk.2	-	1	161	c.130G>A	c.(130-132)GGA>AGA	p.G44R	FARP1_uc001vnh.2_Intron|FARP1_uc001vni.2_Intron|FARP1_uc001vnj.2_Intron	NM_178861	NP_849192	Q8IZP6	R113B_HUMAN	ring finger protein 113B	44							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			CTGCTCTCTCCGTGCTCGGGG	0.692													10	21					0	0	0.000442599	0	0
GPR18	2841	broad.mit.edu	37	13	99907671	99907671	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:99907671C>T	uc001voe.3	-	3	957	c.456G>A	c.(454-456)ACG>ACA	p.T152T	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron|GPR18_uc010afv.2_Silent_p.T152T	NM_005292	NP_005283	Q14330	GPR18_HUMAN	G protein-coupled receptor 18	152	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	GAGGGGTGGTCGTGGTCAGGG	0.498													28	62					0	0	0.00127121	0	0
TPP2	7174	broad.mit.edu	37	13	103295587	103295587	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:103295587C>T	uc001vpi.3	+	17	2139	c.2036C>T	c.(2035-2037)TCG>TTG	p.S679L		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	679					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ACAGTGTGTTCGTGTTCTTCT	0.363													19	43					0	0	0.00229938	0	0
COL4A2	1284	broad.mit.edu	37	13	111111224	111111224	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:111111224G>A	uc001vqx.2	+	22	1828	c.1539G>A	c.(1537-1539)AGG>AGA	p.R513R		NM_001846	NP_001837	P08572	CO4A2_HUMAN	alpha 2 type IV collagen preproprotein	513	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			skin(3)|central_nervous_system(2)|ovary(1)	6	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AGCCGGGGAGGAAAGGGGACA	0.602													27	28					0	0	0.000720815	0	0
CARS2	79587	broad.mit.edu	37	13	111329397	111329397	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:111329397G>A	uc001vrd.2	-	7	749	c.709C>T	c.(709-711)CCC>TCC	p.P237S	CARS2_uc010tjm.1_RNA	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	237					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	ACCTCCTGGGGTTTGGCCGCC	0.632													23	37					0	0	0.00278032	0	0
C13orf28	122258	broad.mit.edu	37	13	113030790	113030790	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:113030790C>T	uc001vsd.1	+	1	122	c.91C>T	c.(91-93)CCA>TCA	p.P31S		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	31						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					AACCGTGATTCCAGGTAGGGC	0.587													8	8					0	0	0.000274275	0	0
OR4K5	79317	broad.mit.edu	37	14	20388956	20388956	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:20388956G>A	uc010tkw.1	+	1	191	c.191G>A	c.(190-192)GGA>GAA	p.G64E		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTCTCTTGGGAAACCTTTCC	0.433													88	139					0	0	0.000781405	0	0
OR4K13	390433	broad.mit.edu	37	14	20502436	20502436	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:20502436G>A	uc010tkz.1	-	1	482	c.482C>T	c.(481-483)GCT>GTT	p.A161V		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		CAACATGAAAGCCATTTGACT	0.468													91	108					0	0	0.000781405	0	0
OR4L1	122742	broad.mit.edu	37	14	20528335	20528335	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:20528335C>T	uc001vwn.1	+	1	132	c.132C>T	c.(130-132)CTC>CTT	p.L44L		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GAAACATTCTCATTATGGTCA	0.398													117	94					0	0	0.000781405	0	0
OR4K17	390436	broad.mit.edu	37	14	20585689	20585689	+	Missense_Mutation	SNP	G	A	A	rs148373137		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:20585689G>A	uc001vwo.1	+	1	124	c.124G>A	c.(124-126)GAA>AAA	p.E42K		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TCAAGTGTCAGAATTCATTTT	0.438													62	114					0	0	0.000781405	0	0
JUB	84962	broad.mit.edu	37	14	23451387	23451387	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:23451387G>A	uc001whz.2	-	1	465	c.89C>T	c.(88-90)ACC>ATC	p.T30I		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	30	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		CGGCCCGGGGGTCCCGTCAGA	0.672													39	20					0	0	0.000953801	0	0
PABPN1	8106	broad.mit.edu	37	14	23792248	23792248	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:23792248T>C	uc001wjk.2	+	3	1789	c.507T>C	c.(505-507)GCT>GCC	p.A169A	PABPN1_uc001wjh.3_Silent_p.A196A|PABPN1_uc001wjj.2_Silent_p.A169A	NM_004643	NP_004634	Q86U42	PABP2_HUMAN	poly(A) binding protein, nuclear 1	169	Necessary for homooligomerization.				modification by virus of host mRNA processing|mRNA 3'-end processing|muscle contraction|nuclear mRNA splicing, via spliceosome|poly(A)+ mRNA export from nucleus|termination of RNA polymerase II transcription|viral infectious cycle	cytoplasm|nucleoplasm|ribonucleoprotein complex	nucleotide binding|protein binding|RNA binding			ovary(2)	2	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		AGATGGAGGCTGATGCCCGTT	0.433													37	96					0	0	0.00285205	0	0
MYH6	4624	broad.mit.edu	37	14	23870134	23870134	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:23870134C>T	uc001wjv.2	-	13	1261	c.1194G>A	c.(1192-1194)AAG>AAA	p.K398K	MYH6_uc010akp.1_Silent_p.K398K	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	398	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGCACAGCCCCTTGAGCAGGT	0.537													14	31					0	0	0.000422831	0	0
CPNE6	9362	broad.mit.edu	37	14	24545039	24545039	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:24545039G>A	uc001wll.2	+	10	967	c.868G>A	c.(868-870)GAG>AAG	p.E290K	CPNE6_uc010tnv.1_Missense_Mutation_p.E345K|CPNE6_uc001wlm.2_Missense_Mutation_p.E115K|CPNE6_uc001wln.2_5'UTR	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	290					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		CCTCCAGGTGGAGAAGGTGCA	0.602													14	33					0	0	0.000566183	0	0
FITM1	161247	broad.mit.edu	37	14	24601566	24601566	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:24601566C>T	uc001wmf.2	+	2	511	c.413C>T	c.(412-414)GCC>GTC	p.A138V		NM_203402	NP_981947	A5D6W6	FITM1_HUMAN	fat-inducing transcript 1	138	Extracellular (Potential).				lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane					0						TGGCGGGGAGCCGGCCGGGCC	0.672													18	47					0	0	0.000958276	0	0
CMA1	1215	broad.mit.edu	37	14	24976608	24976608	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:24976608G>A	uc001wpp.1	-	2	193	c.163C>T	c.(163-165)CTT>TTT	p.L55F	CMA1_uc010alx.1_Intron	NM_001836	NP_001827	P23946	CMA1_HUMAN	chymase 1, mast cell preproprotein	55	Peptidase S1.				interleukin-1 beta biosynthetic process|proteolysis	extracellular region	serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.0271)		CGTCTTATAAGGAAACCACCA	0.488													80	83					0	0	0.000781405	0	0
GZMB	3002	broad.mit.edu	37	14	25102253	25102253	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:25102253C>T	uc001wps.2	-	2	137	c.71G>A	c.(70-72)GGA>GAA	p.G24E	GZMB_uc010ama.2_Missense_Mutation_p.G12E|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor	24	Peptidase S1.				activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		GGCCTCATGTCCCCCGATGAT	0.567													70	88					0	0	0.000781405	0	0
NOVA1	4857	broad.mit.edu	37	14	26917793	26917793	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:26917793G>A	uc001wpy.2	-	5	1214	c.896C>T	c.(895-897)GCC>GTC	p.A299V	NOVA1_uc001wpz.2_Missense_Mutation_p.A275V|NOVA1_uc001wqa.2_Missense_Mutation_p.A177V	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	302	Ala-rich.				locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TGCTGGAAAGGCTGCAACGCC	0.473													25	26					0	0	0.000586117	0	0
HEATR5A	25938	broad.mit.edu	37	14	31774117	31774117	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:31774117G>A	uc001wrf.3	-	26	4431	c.4354C>T	c.(4354-4356)CCT>TCT	p.P1452S	HEATR5A_uc010ami.2_Missense_Mutation_p.P1350S	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1739							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		ATACCTTCAGGAGAGCACACT	0.383													10	28					0	0	0.000673444	0	0
ARHGAP5	394	broad.mit.edu	37	14	32562319	32562319	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:32562319C>T	uc001wrl.2	+	2	2683	c.2444C>T	c.(2443-2445)TCC>TTC	p.S815F	ARHGAP5_uc001wrm.2_Missense_Mutation_p.S815F|ARHGAP5_uc001wrn.2_Missense_Mutation_p.S815F|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	815					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CAGAATAATTCCCTAATGCTT	0.383													46	35					0	0	0.000781405	0	0
NKX2-8	26257	broad.mit.edu	37	14	37051552	37051552	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:37051552G>A	uc001wtx.2	-	1	235	c.43C>T	c.(43-45)CTA>TTA	p.L15L		NM_014360	NP_055175	O15522	NKX28_HUMAN	NK2 homeobox 8	15					liver development|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Breast(36;0.143)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.12e-09)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.00357)|all cancers(34;0.0113)|LUSC - Lung squamous cell carcinoma(13;0.0189)	GBM - Glioblastoma multiforme(112;0.0171)		GGTAAATCTAGAAGGCTGCGC	0.726													24	14					0	0	0.000586117	0	0
CTAGE5	4253	broad.mit.edu	37	14	39818153	39818153	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:39818153C>T	uc001wvg.3	+	23	2556	c.2220C>T	c.(2218-2220)TTC>TTT	p.F740F	CTAGE5_uc001wuz.3_Silent_p.F728F|CTAGE5_uc001wuy.3_Silent_p.F660F|CTAGE5_uc001wvb.3_Silent_p.F668F|CTAGE5_uc001wvc.3_Silent_p.F642F|CTAGE5_uc001wva.3_Silent_p.F711F|CTAGE5_uc001wvh.3_Silent_p.F697F|CTAGE5_uc001wvf.3_Silent_p.F665F|CTAGE5_uc001wvi.3_Silent_p.F745F|CTAGE5_uc010amz.2_Silent_p.F356F|CTAGE5_uc001wvj.3_Silent_p.F711F	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	740	Pro-rich.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		CAGGGGATTTCCCAGGTCCAC	0.423													25	74					0	0	0.000720815	0	0
FSCB	84075	broad.mit.edu	37	14	44975634	44975634	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:44975634G>A	uc001wvn.2	-	1	866	c.557C>T	c.(556-558)TCG>TTG	p.S186L		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	186						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CTTTCCCGACGATTTATGTTT	0.373													40	103					0	0	0.00148497	0	0
C14orf106	55320	broad.mit.edu	37	14	45675348	45675348	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:45675348G>A	uc001wwf.2	-	15	3637	c.3178C>T	c.(3178-3180)CGT>TGT	p.R1060C		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	1060					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						TTTTGCATACGAAAAACATAT	0.259													12	37					0	0	0.000422831	0	0
MAP4K5	11183	broad.mit.edu	37	14	50912825	50912825	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:50912825C>G	uc001wya.2	-	17	1477	c.1157G>C	c.(1156-1158)CGT>CCT	p.R386P	MAP4K5_uc001wyb.2_Missense_Mutation_p.R386P|MAP4K5_uc010anv.1_Missense_Mutation_p.R386P|MAP4K5_uc001wyc.1_Missense_Mutation_p.R60P	NM_006575	NP_006566	Q9Y4K4	M4K5_HUMAN	mitogen-activated protein kinase kinase kinase	386					activation of JUN kinase activity	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(1)	1	all_epithelial(31;0.000415)|Breast(41;0.0102)					TGGTATTGCACGTTTTGAGGT	0.279													13	22					0	0	0.000566183	0	0
DDHD1	80821	broad.mit.edu	37	14	53521309	53521309	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:53521309A>G	uc001xai.2	-	11	2514	c.2284T>C	c.(2284-2286)TTC>CTC	p.F762L	DDHD1_uc001xaj.2_Missense_Mutation_p.F769L|DDHD1_uc001xah.2_Missense_Mutation_p.F762L|DDHD1_uc001xag.2_Missense_Mutation_p.F344L|DDHD1_uc001xak.1_Missense_Mutation_p.F158L	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	762	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					AATCTTGAGAACAACATTCCT	0.443													35	24					0	0	0.00111076	0	0
SAMD4A	23034	broad.mit.edu	37	14	55251268	55251268	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:55251268C>T	uc001xbb.2	+	11	2056	c.2055C>T	c.(2053-2055)CCC>CCT	p.P685P	SAMD4A_uc001xbc.2_Silent_p.P597P|SAMD4A_uc001xbg.2_Silent_p.P313P	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	686					positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						TCCAGCTTCCCGTGACCGAAC	0.542													35	69					0	0	0.00170553	0	0
FBXO34	55030	broad.mit.edu	37	14	55819194	55819194	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:55819194C>T	uc001xbu.2	+	2	2331	c.2086C>T	c.(2086-2088)CGG>TGG	p.R696W	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.R696W	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	696										ovary(2)|lung(2)|skin(1)	5						CAGCTTTAATCGGGCAATCCA	0.488													20	17					0	0	0.00121646	0	0
TBPL2	387332	broad.mit.edu	37	14	55902610	55902610	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:55902610C>T	uc001xby.2	-	3	651	c.651G>A	c.(649-651)CTG>CTA	p.L217L		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	217					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						CTATTTTCTTCAGATCCAACT	0.299													22	54					0	0	0.00106085	0	0
SLC35F4	341880	broad.mit.edu	37	14	58060803	58060803	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:58060803G>T	uc001xdb.1	-	2	251	c.251C>A	c.(250-252)GCC>GAC	p.A84D	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_5'UTR	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						GGGGCAGTTGGCTCCTGGTTT	0.463													13	10					7.03913e-09	2.40122e-08	0.00136819	1	0
SIX1	6495	broad.mit.edu	37	14	61113243	61113243	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:61113243G>A	uc001xfb.3	-	2	861	c.613C>T	c.(613-615)CCT>TCT	p.P205S		NM_005982	NP_005973	Q15475	SIX1_HUMAN	SIX homeobox 1	205					branching involved in ureteric bud morphogenesis|embryonic cranial skeleton morphogenesis|epithelial cell differentiation|inner ear morphogenesis|mesonephric tubule formation|metanephric mesenchyme development|myoblast migration|negative regulation of neuron apoptosis|organ induction|pattern specification process|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|protein localization to nucleus|regulation of branch elongation involved in ureteric bud branching|regulation of neuron differentiation|skeletal muscle tissue development|thymus development|thyroid gland development	nucleolus|transcription factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.0201)		CCTTCCAGAGGAGAGAGTTGG	0.458													43	27					0	0	0.000781405	0	0
SIX4	51804	broad.mit.edu	37	14	61180337	61180337	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:61180337G>A	uc001xfc.2	-	3	2134	c.2134C>T	c.(2134-2136)CGT>TGT	p.R712C		NM_017420	NP_059116	Q9UIU6	SIX4_HUMAN	sine oculis homeobox homolog 4	712						nucleus				breast(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(108;0.0275)		AGAACCAAACGATGTTCTTGG	0.443													15	30					0	0	0.000308642	0	0
MTHFD1	4522	broad.mit.edu	37	14	64898303	64898303	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:64898303C>T	uc001xhb.2	+	14	1752	c.1365C>T	c.(1363-1365)CTC>CTT	p.L455L	MTHFD1_uc010aqe.2_Silent_p.L491L|MTHFD1_uc010aqf.2_Silent_p.L511L	NM_005956	NP_005947	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase 1	455	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|methylenetetrahydrofolate dehydrogenase|protein binding			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CTAATAACCTCGTTGCTGCGG	0.468													32	22					0	0	0.000814825	0	0
SPTB	6710	broad.mit.edu	37	14	65233428	65233428	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:65233428G>A	uc001xht.2	-	31	6415	c.6361C>T	c.(6361-6363)CGT>TGT	p.R2121C	SPTB_uc001xhr.2_Intron|SPTB_uc001xhs.2_Intron|SPTB_uc001xhu.2_Missense_Mutation_p.R2121C|SPTB_uc010aqi.2_Intron	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2121					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTAGACAAACGAGACCAGAGA	0.637													36	112					0	0	0.000953801	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634988	70634988	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:70634988G>A	uc001xly.2	-	2	906	c.152C>T	c.(151-153)TCA>TTA	p.S51L	SLC8A3_uc001xlw.2_Missense_Mutation_p.S51L|SLC8A3_uc001xlx.2_Missense_Mutation_p.S51L|SLC8A3_uc001xlz.2_Missense_Mutation_p.S51L|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	51	Extracellular (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCAGTCCGATGACCCTGAACA	0.557													24	14					0	0	0.000720815	0	0
MAP3K9	4293	broad.mit.edu	37	14	71267682	71267682	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:71267682G>A	uc001xmm.2	-	2	522	c.522C>T	c.(520-522)CGC>CGT	p.R174R	MAP3K9_uc001xml.2_Silent_p.R174R	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	174	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CAGGGTCGTGGCGAGCTGCTT	0.537													27	68					0	0	0.00106085	0	0
PCNX	22990	broad.mit.edu	37	14	71435813	71435813	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:71435813G>A	uc001xmo.2	+	5	1036	c.590G>A	c.(589-591)GGA>GAA	p.G197E	PCNX_uc001xmn.3_Missense_Mutation_p.G197E|PCNX_uc010are.1_Missense_Mutation_p.G197E	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	197						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TGTAAGGAAGGAAGTGAAGAA	0.368													99	84					0	0	0.000781405	0	0
PCNX	22990	broad.mit.edu	37	14	71575703	71575703	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:71575703C>T	uc001xmo.2	+	34	7130	c.6684C>T	c.(6682-6684)AAC>AAT	p.N2228N	PCNX_uc010are.1_Silent_p.N2117N|PCNX_uc010arf.1_Silent_p.N1016N|PCNX_uc001xmp.2_Silent_p.N312N	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	2228						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AGCCAGGCAACACCTTAAGTC	0.512													21	48					0	0	0.00278032	0	0
PROX2	283571	broad.mit.edu	37	14	75329637	75329637	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:75329637C>T	uc001xqr.1	-	1	901	c.901G>A	c.(901-903)GGA>AGA	p.G301R	PROX2_uc001xqq.1_Intron	NM_001080408	NP_001073877	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	301					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GATAAATTTCCTACTGGGACC	0.552													59	37					0	0	0.000781405	0	0
RPS6KL1	83694	broad.mit.edu	37	14	75376333	75376333	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:75376333C>T	uc010tux.1	-	7	1711	c.1183G>A	c.(1183-1185)GAG>AAG	p.E395K	RPS6KL1_uc001xqx.1_Missense_Mutation_p.E147K|RPS6KL1_uc001xqw.2_Missense_Mutation_p.E364K|RPS6KL1_uc010asd.1_RNA	NM_031464	NP_113652	Q9Y6S9	RPKL1_HUMAN	ribosomal protein S6 kinase-like 1	395	Protein kinase.					ribosome	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00658)		ACCAGCATCTCTGCCGCCCAC	0.687													21	50					0	0	0.00047179	0	0
STON2	85439	broad.mit.edu	37	14	81743428	81743428	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:81743428G>A	uc010tvu.1	-	4	2428	c.2227C>T	c.(2227-2229)CGC>TGC	p.R743C	STON2_uc001xvk.1_Missense_Mutation_p.R743C|STON2_uc010tvt.1_Missense_Mutation_p.R540C	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	743	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CTTTCCCTGCGGAAGTTTTTC	0.537													26	80					0	0	0.000878237	0	0
GPR65	8477	broad.mit.edu	37	14	88477762	88477762	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:88477762G>A	uc001xvv.2	+	2	1101	c.571G>A	c.(571-573)GGC>AGC	p.G191S		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	191	Helical; Name=5; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						GACGTGTACAGGCTATGCAAT	0.413													40	32					0	0	0.00222228	0	0
EML5	161436	broad.mit.edu	37	14	89181355	89181355	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:89181355C>T	uc001xxg.2	-	10	1558	c.1372G>A	c.(1372-1374)GAC>AAC	p.D458N	EML5_uc001xxh.1_5'UTR	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	458	WD 9.					cytoplasm|microtubule				ovary(3)	3						GAAGACCAGTCCAGATGAGTG	0.373													24	41					0	0	0.000586117	0	0
C14orf159	80017	broad.mit.edu	37	14	91647628	91647628	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:91647628C>T	uc001xzb.2	+	10	1582	c.814C>T	c.(814-816)CCA>TCA	p.P272S	C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Missense_Mutation_p.P277S|C14orf159_uc001xyx.2_Missense_Mutation_p.P260S|C14orf159_uc001xyw.2_Missense_Mutation_p.P277S|C14orf159_uc001xzc.2_Missense_Mutation_p.P272S|C14orf159_uc001xza.2_Missense_Mutation_p.P277S|C14orf159_uc001xyv.2_Missense_Mutation_p.P277S|C14orf159_uc001xyz.2_Missense_Mutation_p.P148S|C14orf159_uc001xze.2_Missense_Mutation_p.P272S	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	272						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		AGAGAGAATTCCAGAGGTCCA	0.512													18	44					0	0	0.00074312	0	0
CCDC88C	440193	broad.mit.edu	37	14	91755607	91755607	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:91755607G>A	uc010aty.2	-	25	4382	c.4283C>T	c.(4282-4284)TCC>TTC	p.S1428F		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1428					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GTCCACGGTGGATTTTAAGCG	0.572													48	187					0	0	0.000781405	0	0
CCDC88C	440193	broad.mit.edu	37	14	91780260	91780260	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:91780260C>T	uc010aty.2	-	15	1999	c.1900G>A	c.(1900-1902)GAG>AAG	p.E634K		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	634	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				AGCTCCCTCTCCAGCTTCTCT	0.627													23	8					0	0	0.00278032	0	0
KIAA1409	57578	broad.mit.edu	37	14	94152932	94152932	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:94152932G>A	uc001ybv.1	+	42	6569	c.6486G>A	c.(6484-6486)GCG>GCA	p.A2162A	KIAA1409_uc001ybs.1_Silent_p.A2140A	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2317						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GGACTGCAGCGATGGAGTGTG	0.507													15	34					0	0	0.000422831	0	0
PPP4R4	57718	broad.mit.edu	37	14	94712823	94712823	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:94712823G>A	uc001ycs.1	+	14	1712	c.1558G>A	c.(1558-1560)GAT>AAT	p.D520N		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	520						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						CATATCAAGCGATCAGATTTA	0.403													74	47					0	0	0.000781405	0	0
PPP4R4	57718	broad.mit.edu	37	14	94722887	94722887	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:94722887G>A	uc001ycs.1	+	17	2110	c.1956G>A	c.(1954-1956)GTG>GTA	p.V652V		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	652						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						AAATGTGTGTGAGGAAACTCC	0.363													20	19					0	0	0.00152264	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030123	95030123	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:95030123C>T	uc001ydk.2	+	2	370	c.304C>T	c.(304-306)CTT>TTT	p.L102F	SERPINA4_uc010avd.2_Missense_Mutation_p.L139F|SERPINA4_uc001ydl.2_Missense_Mutation_p.L102F	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	102					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CAGCCAGATCCTTGAGGGCCT	0.632													13	33					0	0	0.00185496	0	0
SERPINA4	5267	broad.mit.edu	37	14	95030225	95030225	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:95030225G>A	uc001ydk.2	+	2	472	c.406G>A	c.(406-408)GAA>AAA	p.E136K	SERPINA4_uc010avd.2_Missense_Mutation_p.E173K|SERPINA4_uc001ydl.2_Missense_Mutation_p.E136K	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	136					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CCATGGGCTGGAAACACGCGT	0.567													44	36					0	0	0.000781405	0	0
SERPINA4	5267	broad.mit.edu	37	14	95033498	95033498	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:95033498C>T	uc001ydk.2	+	3	907	c.841C>T	c.(841-843)CCT>TCT	p.P281S	SERPINA4_uc010avd.2_Missense_Mutation_p.P318S|SERPINA4_uc001ydl.2_Missense_Mutation_p.P281S	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	281					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		TTTCATTCTCCCTAACCAAGG	0.483													18	27					0	0	0.000958276	0	0
SERPINA5	5104	broad.mit.edu	37	14	95053780	95053780	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:95053780G>A	uc001ydm.2	+	3	291	c.81G>A	c.(79-81)ATG>ATA	p.M27I	SERPINA5_uc010ave.2_Missense_Mutation_p.M27I|SERPINA5_uc001ydn.1_Missense_Mutation_p.M27I	NM_000624	NP_000615	P05154	IPSP_HUMAN	serine (or cysteine) proteinase inhibitor, clade	27					fusion of sperm to egg plasma membrane|regulation of proteolysis|spermatogenesis	extracellular region|membrane|protein complex	acrosin binding|heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(2)	2				COAD - Colon adenocarcinoma(157;0.21)	Drotrecogin alfa(DB00055)|Urokinase(DB00013)	CCCGGGAGATGAAGAAGAGAG	0.612													29	58					0	0	0.00127121	0	0
SERPINA3	12	broad.mit.edu	37	14	95081243	95081243	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:95081243G>A	uc001ydp.2	+	2	544	c.465G>A	c.(463-465)GAG>GAA	p.E155E	SERPINA3_uc001ydo.3_Silent_p.E180E|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Silent_p.E155E|SERPINA3_uc001yds.2_Silent_p.E155E|SERPINA3_uc010avg.2_Silent_p.E155E	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	155					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GGTTCACGGAGGATGCCAAGA	0.522													36	31					0	0	0.00283554	0	0
ATG2B	55102	broad.mit.edu	37	14	96811000	96811000	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:96811000C>T	uc001yfi.2	-	4	937	c.572G>A	c.(571-573)CGA>CAA	p.R191Q		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	191										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		CCTTTCTATTCGAATTTCAAG	0.313													15	31					0	0	0.00244969	0	0
C14orf177	283598	broad.mit.edu	37	14	99183513	99183513	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:99183513C>T	uc001yfz.1	+	4	699	c.280C>T	c.(280-282)CAC>TAC	p.H94Y		NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598	94											0		Melanoma(154;0.128)				GTCATGTAATCACCAAATAAT	0.423													39	28					0	0	0.00170553	0	0
BCL11B	64919	broad.mit.edu	37	14	99641447	99641447	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:99641447C>T	uc001yga.2	-	4	1993	c.1726G>A	c.(1726-1728)GTC>ATC	p.V576I	BCL11B_uc001ygb.2_Missense_Mutation_p.V505I	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	576	Gly-rich.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		gcgcccgggaccccgggcACC	0.537			T	TLX3	T-ALL								7	12					0	0	0.000157383	0	0
MIR409	574413	broad.mit.edu	37	14	101531652	101531652	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:101531652G>A	hsa-mir-409|MI0001735	+			c.16G>A			MIR412_hsa-mir-412|MI0002464_5'Flank|uc010txp.1_5'Flank|MIR369_hsa-mir-369|MI0000777_5'Flank|MIR410_hsa-mir-410|MI0002465_5'Flank|MIR656_hsa-mir-656|MI0003678_5'Flank																	0						CTCGGGGAGAGGTTACCCGAG	0.582													14	32					0	0	0.00185496	0	0
ASPG	374569	broad.mit.edu	37	14	104570685	104570685	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:104570685G>A	uc001yoq.1	+	8	858	c.798G>A	c.(796-798)GAG>GAA	p.E266E	ASPG_uc001yoo.1_Silent_p.E294E|ASPG_uc001yop.1_Silent_p.E266E|ASPG_uc001yor.1_Silent_p.E266E	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	266	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						TGGTCATGGAGACCTTCGGTT	0.672													26	14					0	0	0.00106085	0	0
KIF26A	26153	broad.mit.edu	37	14	104643572	104643572	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:104643572G>A	uc001yos.3	+	12	4447	c.4447G>A	c.(4447-4449)GGC>AGC	p.G1483S		NM_015656	NP_056471	Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1483					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			pancreas(1)	1		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CTGTAGGAGCGGCGCAGCCAA	0.726													12	8					0	0	0.00244969	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413991	105413991	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:105413991C>T	uc010axc.1	-	7	7917	c.7797G>A	c.(7795-7797)AAG>AAA	p.K2599K	AHNAK2_uc001ypx.2_Silent_p.K2499K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2599						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCACTTCCGCCTTGGGGCCTT	0.622													107	73					0	0	0.000781405	0	0
JAG2	3714	broad.mit.edu	37	14	105615329	105615329	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:105615329C>T	uc001yqg.2	-	14	2255	c.1851G>A	c.(1849-1851)GGG>GGA	p.G617G	JAG2_uc010axf.2_5'Flank|JAG2_uc001yqf.2_Silent_p.G21G|JAG2_uc001yqh.2_Silent_p.G579G	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	617	Extracellular (Potential).|EGF-like 10; atypical.				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		AAAAGTTGCCCCCTGGCTGGC	0.662													5	17					0	0	0.00116845	0	0
ADAM6	8755	broad.mit.edu	37	14	106067917	106067917	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106067917C>T	uc010tyt.1	-	3649		c.62740G>A			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Missense_Mutation_p.G64E|uc001yrx.1_Missense_Mutation_p.G11E|uc001yrv.1_5'Flank|uc001yru.2_5'Flank|uc010axq.1_5'Flank					Parts of antibodies, mostly variable regions.												0						CATAGTTGTCCCGTTGAGGGA	0.612													17	57					0	0	0.000422831	0	0
ADAM6	8755	broad.mit.edu	37	14	106322014	106322014	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106322014G>A	uc010tyt.1	-	3598		c.55472C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_Intron|uc001yse.2_Intron|uc001ysf.2_Intron|uc001ysj.2_Intron|uc001ysk.1_Intron|uc001ysl.1_Intron|uc001ysm.1_Intron|uc001ysn.1_Intron|uc001yso.1_Intron					Parts of antibodies, mostly variable regions.												0						CCCTCACCTGGAAGAGGCACG	0.642													61	44					0	0	0.000781405	0	0
ADAM6	8755	broad.mit.edu	37	14	106331497	106331497	+	RNA	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106331497A>T	uc010tyt.1	-	3486		c.53191T>A			uc001yrs.2_5'Flank|uc001yrt.2_5'Flank|uc001yrw.1_5'Flank|uc001yrx.1_5'Flank|uc001yrz.1_5'Flank|uc001yse.2_5'Flank|uc001ysf.2_Intron|uc001ysj.2_5'Flank|uc001ysk.1_5'Flank|uc001ysl.1_5'Flank|uc001ysm.1_5'Flank|uc001ysn.1_5'Flank|uc001yso.1_Intron					Parts of antibodies, mostly variable regions.												0						CCATACAAAAACACACCCTCC	0.607													6	8					0	0	0.00198382	0	0
ADAM6	8755	broad.mit.edu	37	14	106376339	106376339	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106376339C>T	uc010tyt.1	-	2710		c.45837_splice	c.e2710-1		KIAA0125_uc001ysq.2_Intron|KIAA0125_uc001ysr.2_Intron|KIAA0125_uc001yss.2_Intron					Parts of antibodies, mostly variable regions.												0						GGGACCTTCCCTTGCTGGGCT	0.582													18	17					0	0	0.00152264	0	0
ADAM6	8755	broad.mit.edu	37	14	106641620	106641620	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106641620G>A	uc010tyt.1	-	1021		c.24381C>T								Parts of antibodies, mostly variable regions.												0						GCTCCATGTAGGCTGTGCTCG	0.527													45	147					0	0	0.000781405	0	0
ADAM6	8755	broad.mit.edu	37	14	106725138	106725138	+	RNA	SNP	C	T	T	rs61750790	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106725138C>T	uc010tyt.1	-	589		c.18376G>A								Parts of antibodies, mostly variable regions.												0						CGCTGATTTCCCCCCCATCGT	0.587													32	38					0	0	0.00283554	0	0
ADAM6	8755	broad.mit.edu	37	14	106733218	106733218	+	RNA	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106733218T>C	uc010tyt.1	-	547		c.17518A>G								Parts of antibodies, mostly variable regions.												0						TCTGTAGATGTGTCCTCGGTC	0.512													116	99					0	0	0.000781405	0	0
ADAM6	8755	broad.mit.edu	37	14	106733222	106733222	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106733222C>T	uc010tyt.1	-	547		c.17514G>A								Parts of antibodies, mostly variable regions.												0						TAGATGTGTCCTCGGTCATGG	0.512													59	147					0	0	0.000781405	0	0
ADAM6	8755	broad.mit.edu	37	14	106774146	106774146	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:106774146G>A	uc010tyt.1	-	430		c.15615C>T								Parts of antibodies, mostly variable regions.												0						AGGTGTCCATGGAGAAGACAA	0.532													9	8					0	0	0.000274275	0	0
BCL8	606	broad.mit.edu	37	15	20876510	20876510	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:20876510A>G	uc010tze.1	-	2	310	c.103T>C	c.(103-105)TTG>CTG	p.L35L	BCL8_uc010tzd.1_RNA	NR_027992				RecName: Full=Putative protein BCL8;												0						TGCTTCAGCAAAGGTACTCCA	0.333													11	110					0	0	0.000673444	0	0
NF1P1	440225	broad.mit.edu	37	15	22145390	22145390	+	RNA	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:22145390A>C	uc010tzs.1	-	2		c.293T>G								Human NF1-related locus DNA in A9 mouse DNA background.												0						GAGAACAAGGAACCACACTGG	0.348													9	33					0	0	0.00185496	0	0
CYFIP1	23191	broad.mit.edu	37	15	22945107	22945107	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:22945107T>A	uc001yus.2	+	12	1282	c.1178T>A	c.(1177-1179)CTG>CAG	p.L393Q	CYFIP1_uc001yut.2_Missense_Mutation_p.L393Q|CYFIP1_uc010aya.1_Missense_Mutation_p.L421Q	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	393					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CTCTTCGACCTGGCGCTGCAG	0.701													10	9					0	0	0.000673444	0	0
CYFIP1	23191	broad.mit.edu	37	15	22999452	22999452	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:22999452C>T	uc001yus.2	+	29	3428	c.3324C>T	c.(3322-3324)ATC>ATT	p.I1108I	CYFIP1_uc001yut.2_Silent_p.I1108I|CYFIP1_uc001yuu.2_Silent_p.I677I|CYFIP1_uc001yuv.2_Silent_p.I302I	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	1108					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ATGACCCCATCTGGCGCGGGC	0.587													22	34					0	0	0.00278032	0	0
HERC2P2	400322	broad.mit.edu	37	15	23299951	23299951	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:23299951G>A	uc001yvq.2	-	4		c.1554C>T			HERC2P2_uc001yvo.3_RNA|HERC2P2_uc001yvp.3_RNA					Homo sapiens mRNA for KIAA0393 protein, partial cds.												0						GCACCAGTGAGAGACTTCAGG	0.577													13	11					0	0	0.000308642	0	0
C15orf2	23742	broad.mit.edu	37	15	24923694	24923694	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:24923694G>A	uc001ywo.2	+	1	3154	c.2680G>A	c.(2680-2682)GGA>AGA	p.G894R		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	894					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTTAAATACAGGATCCATCTC	0.502													87	84					0	0	0.000781405	0	0
PAR4	347745	broad.mit.edu	37	15	25451265	25451265	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:25451265G>A	uc001yzk.1	+	10		c.1483G>A			PAR4_uc010ayo.1_Intron|SNORD115-20_uc001yzq.1_5'Flank					Homo sapiens clone Rt-13I SNURF-SNRPN mRNA, downstream untranslated exons, alternatively spliced.												0						CGTGGCTCTGGGCCAGTGTGC	0.632													11	6					0	0	0.000673444	0	0
ATP10A	57194	broad.mit.edu	37	15	26026240	26026240	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:26026240G>A	uc010ayu.2	-	2	686	c.580C>T	c.(580-582)CAC>TAC	p.H194Y		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	194	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GTCTCGATGTGGCATAGCCCG	0.592													31	50					0	0	0.001512	0	0
GABRG3	2567	broad.mit.edu	37	15	27572008	27572008	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:27572008G>A	uc001zbg.1	+	4	489	c.323G>A	c.(322-324)CGA>CAA	p.R108Q	GABRG3_uc001zbf.2_Missense_Mutation_p.R108Q	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	108	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AGTCGCCTTCGATTCAACAGC	0.418													93	102					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	15	28903845	28903845	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:28903845C>T	uc010azc.2	+	5		c.777C>T			uc010uao.1_RNA					Homo sapiens I.M.A.G.E. clone 321824, mRNA sequence.																		CGCTGTTCTCCCACCAGGATA	0.498													43	32					0	0	0.000781405	0	0
Unknown	0	broad.mit.edu	37	15	28903876	28903876	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:28903876C>T	uc010azc.2	+	5		c.808C>T			uc010uao.1_RNA					Homo sapiens I.M.A.G.E. clone 321824, mRNA sequence.																		GATCCTGTCTCAGCCAGCTGT	0.488													51	73					0	0	0.000781405	0	0
OTUD7A	161725	broad.mit.edu	37	15	31776795	31776795	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:31776795C>T	uc001zfq.2	-	11	1576	c.1483G>A	c.(1483-1485)GAC>AAC	p.D495N	OTUD7A_uc001zfr.2_Missense_Mutation_p.D502N	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	495	Nuclear localization signal (Potential).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		ttctccttgtccttGCCGTTC	0.498													10	10					0	0	0.000978159	0	0
RYR3	6263	broad.mit.edu	37	15	34130518	34130518	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:34130518G>A	uc001zhi.2	+	89	12407	c.12337G>A	c.(12337-12339)GAG>AAG	p.E4113K	RYR3_uc010bar.2_Missense_Mutation_p.E4108K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4113					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGGCCAGAAGAGGAGGAAGA	0.473													92	83					0	0	0.000781405	0	0
AVEN	57099	broad.mit.edu	37	15	34159738	34159739	+	Silent	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:34159738_34159739GG>AA	uc001zhj.2	-	5	986_987	c.930_931CC>TT	c.(928-933)GACCTG>GATTTG	p.310_311DL>DL		NM_020371	NP_065104	Q9NQS1	AVEN_HUMAN	cell death regulator aven	310_311					anti-apoptosis|apoptosis	endomembrane system|intracellular|membrane|membrane fraction	protein binding			kidney(1)	1		all_lung(180;1.78e-08)		all cancers(64;1.66e-15)|GBM - Glioblastoma multiforme(113;1.42e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0359)		TTGGATTTCAGGTCCTGAGACG	0.426													37	59					0	0	6.4e-05	0	0
CHRM5	1133	broad.mit.edu	37	15	34356068	34356068	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:34356068G>A	uc001zhk.1	+	3	1820	c.1150G>A	c.(1150-1152)GTG>ATG	p.V384M	CHRM5_uc001zhl.1_Missense_Mutation_p.V384M	NM_012125	NP_036257	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	384	Cytoplasmic (By similarity).				cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	GTTCCGATTGGTGGTAAAAGC	0.493													46	49					0	0	0.000680045	0	0
C15orf55	256646	broad.mit.edu	37	15	34640841	34640841	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:34640841C>T	uc001zif.2	+	2	843	c.688C>T	c.(688-690)CAG>TAG	p.Q230*	C15orf55_uc010ucc.1_Nonsense_Mutation_p.Q258*|C15orf55_uc010ucd.1_Nonsense_Mutation_p.Q248*	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	230						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GCACCTATCCCAGAGTCCTGA	0.483			T	BRD3|BRD4	lethal midline carcinoma								41	51					0	0	0.000680045	0	0
C15orf55	256646	broad.mit.edu	37	15	34647955	34647955	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:34647955G>A	uc001zif.2	+	7	1817	c.1662G>A	c.(1660-1662)GGG>GGA	p.G554G	C15orf55_uc010ucc.1_Silent_p.G582G|C15orf55_uc010ucd.1_Silent_p.G572G	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	554						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		ACAGGGATGGGAACACTCTGC	0.592			T	BRD3|BRD4	lethal midline carcinoma								39	52					0	0	0.00148497	0	0
C15orf55	256646	broad.mit.edu	37	15	34649428	34649428	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:34649428T>C	uc001zif.2	+	7	3290	c.3135T>C	c.(3133-3135)GGT>GGC	p.G1045G	C15orf55_uc010ucc.1_Silent_p.G1073G|C15orf55_uc010ucd.1_Silent_p.G1063G	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	1045						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CCTCAGGAGGTCAGGGCAGCC	0.557			T	BRD3|BRD4	lethal midline carcinoma								12	63					0	0	0.00136819	0	0
LPCAT4	254531	broad.mit.edu	37	15	34651861	34651861	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:34651861G>A	uc001zig.2	-	13	1422	c.1328C>T	c.(1327-1329)TCA>TTA	p.S443L		NM_153613	NP_705841	Q643R3	LPCT4_HUMAN	lysophosphatidylcholine acyltransferase 4	443					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|calcium ion binding				0						AGGGTGGGGTGAACCCAGCAG	0.602													21	29					0	0	0.00121646	0	0
AQR	9716	broad.mit.edu	37	15	35202380	35202380	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:35202380G>A	uc001ziv.2	-	17	1800	c.1619C>T	c.(1618-1620)ACC>ATC	p.T540I		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	540						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		GAGATTTATGGTAACATCTGC	0.438													62	84					0	0	0.000781405	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40259920	40259920	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:40259920C>T	uc001zkm.1	+	9	1443	c.1393C>T	c.(1393-1395)CGT>TGT	p.R465C	EIF2AK4_uc001zkl.2_Missense_Mutation_p.R465C|EIF2AK4_uc010bbj.1_Missense_Mutation_p.R194C	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha	465	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			lung(2)|stomach(1)|skin(1)	4		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		AACCCGAGTTCGTTTTAGTGA	0.498													44	52					0	0	0.000781405	0	0
RPUSD2	27079	broad.mit.edu	37	15	40865983	40865983	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:40865983C>T	uc001zmd.1	+	3	1161	c.1161C>T	c.(1159-1161)CCC>CCT	p.P387P		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	387					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		TCAACGACCCCATCTACAACT	0.597													33	36					0	0	0.00058488	0	0
CASC5	57082	broad.mit.edu	37	15	40902456	40902456	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:40902456G>A	uc010bbs.1	+	6	372	c.211G>A	c.(211-213)GAG>AAG	p.E71K	CASC5_uc010ucq.1_5'UTR|CASC5_uc001zme.2_Missense_Mutation_p.E71K|CASC5_uc010bbt.1_Missense_Mutation_p.E71K	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	71	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		ATTCCAGACGGAGTCTCATAT	0.308													45	57					0	0	0.000781405	0	0
DLL4	54567	broad.mit.edu	37	15	41224579	41224580	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:41224579_41224580GG>AA	uc001zng.1	+	6	1104_1105	c.784_785GG>AA	c.(784-786)GGC>AAC	p.G262N		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	262	EGF-like 2.|Extracellular (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CTGTCGCCACGGCACCTGCAGC	0.614													67	70					0	0	6.4e-05	0	0
DLL4	54567	broad.mit.edu	37	15	41229658	41229658	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:41229658G>A	uc001zng.1	+	10	2306	c.1986G>A	c.(1984-1986)AGG>AGA	p.R662R		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	662	Cytoplasmic (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GCTCCCCCAGGGACTCCATGT	0.552													116	104					0	0	0.000781405	0	0
RTF1	23168	broad.mit.edu	37	15	41750008	41750008	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:41750008T>G	uc001zny.2	+	4	608	c.596T>G	c.(595-597)ATG>AGG	p.M199R		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	199	Glu-rich.				histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		CTGGAACAGATGACAGAGAAA	0.502													61	89					0	0	0.000781405	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42434766	42434766	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:42434766G>A	uc001zoz.2	-	19	2352	c.2289C>T	c.(2287-2289)TTC>TTT	p.F763F	PLA2G4F_uc010bcq.2_Silent_p.F60F|PLA2G4F_uc001zoy.2_Silent_p.F395F|PLA2G4F_uc010bcr.2_Silent_p.F514F|PLA2G4F_uc001zpa.2_Silent_p.F514F|PLA2G4F_uc010bcs.2_Silent_p.F550F	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	763	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		TAACCAGGGGGAAGTGCAGCA	0.632													35	43					0	0	0.00195071	0	0
GANC	2595	broad.mit.edu	37	15	42566701	42566701	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:42566701G>A	uc001zpi.2	+	1	336	c.22G>A	c.(22-24)GAA>AAA	p.E8K	GANC_uc001zph.2_Missense_Mutation_p.E8K|GANC_uc001zpj.1_5'Flank|TMEM87A_uc010udd.1_5'Flank|TMEM87A_uc001zpf.3_5'Flank|TMEM87A_uc010bcu.1_5'Flank|TMEM87A_uc001zpg.2_5'Flank|GANC_uc010ude.1_Missense_Mutation_p.E8K	NM_198141	NP_937784	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	8					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			central_nervous_system(2)	2		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		AGTGAAAGAGGAAATAAGGTA	0.483													15	13					0	0	0.000958276	0	0
TP53BP1	7158	broad.mit.edu	37	15	43773106	43773106	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:43773106G>A	uc001zrs.2	-	5	619	c.471C>T	c.(469-471)TCC>TCT	p.S157S	TP53BP1_uc010udp.1_Silent_p.S157S|TP53BP1_uc001zrq.3_Silent_p.S162S|TP53BP1_uc001zrr.3_Silent_p.S162S|TP53BP1_uc010udq.1_Silent_p.S162S	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	157					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CAGCACCAAGGGAATGTGTAG	0.289								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					42	35					0	0	0.0025221	0	0
SPG11	80208	broad.mit.edu	37	15	44865754	44865754	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:44865754G>A	uc001ztx.2	-	32	6227	c.6196C>T	c.(6196-6198)CAG>TAG	p.Q2066*	SPG11_uc010bdw.2_Intron|SPG11_uc010ueh.1_Intron|SPG11_uc010uei.1_Nonsense_Mutation_p.Q2066*|SPG11_uc001zty.1_Nonsense_Mutation_p.Q795*	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	2066	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCTGTTCCCTGTGATGAAGTA	0.527													22	22					0	0	0.00188189	0	0
DUOX2	50506	broad.mit.edu	37	15	45393430	45393430	+	Missense_Mutation	SNP	G	A	A	rs144153950		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:45393430G>A	uc010bea.2	-	22	3097	c.2894C>T	c.(2893-2895)TCG>TTG	p.S965L	DUOX2_uc001zun.2_Missense_Mutation_p.S965L	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	965	Cytoplasmic (Potential).|Interaction with TXNDC11 (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		AGTGATGAACGAGACTCGACA	0.542													8	14					0	0	0.000157383	0	0
DUOXA2	405753	broad.mit.edu	37	15	45410015	45410015	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:45410015C>T	uc001zuo.2	+	6	1151	c.871C>T	c.(871-873)CAG>TAG	p.Q291*	DUOXA2_uc010beb.2_RNA|DUOXA1_uc010uem.1_Intron|DUOXA1_uc001zup.2_Intron|DUOXA1_uc010bec.2_Intron	NM_207581	NP_997464	Q1HG44	DOXA2_HUMAN	dual oxidase activator 2	291	Cytoplasmic (Potential).				protein transport	endoplasmic reticulum membrane|integral to membrane					0		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		GGACTGCAGCCAGGAGAGAGG	0.612											OREG0023102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	67					0	0	0.000781405	0	0
SLC28A2	9153	broad.mit.edu	37	15	45559976	45559976	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:45559976G>A	uc001zva.2	+	12	1246	c.1181G>A	c.(1180-1182)GGG>GAG	p.G394E		NM_004212	NP_004203	O43868	S28A2_HUMAN	solute carrier family 28 (sodium-coupled	394					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			ovary(4)	4		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		AGTGAGGAGGGGGTAAAGCTG	0.547													78	113					0	0	0.000781405	0	0
GATM	2628	broad.mit.edu	37	15	45657033	45657033	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:45657033C>T	uc001zvc.2	-	7	1333	c.1004G>A	c.(1003-1005)TGG>TAG	p.W335*	GATM_uc001zvb.2_Nonsense_Mutation_p.W206*|GATM_uc010uev.1_Nonsense_Mutation_p.W388*	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	335					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	AATGATAGTCCATCCTGCTTT	0.338													17	24					0	0	0.00121646	0	0
SLC12A1	6557	broad.mit.edu	37	15	48500135	48500135	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:48500135C>T	uc001zwn.3	+	2	435	c.219C>T	c.(217-219)TTC>TTT	p.F73F	SLC12A1_uc010uew.1_Intron|SLC12A1_uc010bem.2_Silent_p.F73F|SLC12A1_uc010uex.1_Silent_p.F73F	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	73	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	ATGACAATTTCCTCCAAAGTG	0.428													47	45					0	0	0.00285205	0	0
SPPL2A	84888	broad.mit.edu	37	15	51012216	51012216	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:51012216G>A	uc001zyv.2	-	14	1589	c.1409C>T	c.(1408-1410)CCT>CTT	p.P470L		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	470	Helical; (Potential).					integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		AAGTGTGCAAGGTACTAAATA	0.413													38	32					0	0	0.00148497	0	0
CCPG1	9236	broad.mit.edu	37	15	55664196	55664196	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:55664196G>A	uc002acv.1	-	6	666	c.501C>T	c.(499-501)ACC>ACT	p.T167T	CCPG1_uc002acy.2_Silent_p.T167T|CCPG1_uc002acu.1_Silent_p.T23T|CCPG1_uc002acw.1_5'UTR|CCPG1_uc002acx.2_Silent_p.T167T|CCPG1_uc010bfk.1_Silent_p.T167T|CCPG1_uc002acz.1_Silent_p.T167T	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	167	Cytoplasmic (Potential).|Interaction with MCF2L and SRC (By similarity).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		GCTGATTACTGGTTTCATCAC	0.418													20	35					0	0	0.00121646	0	0
CGNL1	84952	broad.mit.edu	37	15	57730875	57730875	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:57730875C>T	uc002aeg.2	+	2	754	c.678C>T	c.(676-678)GAC>GAT	p.D226D	CGNL1_uc010bfw.2_Silent_p.D226D	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	226	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		TCATAGAGGACCCCAAAAAGC	0.562													36	88					0	0	0.000692331	0	0
ADAM10	102	broad.mit.edu	37	15	58936118	58936118	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:58936118G>A	uc002afd.1	-	7	1239	c.795C>T	c.(793-795)ATC>ATT	p.I265I	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	265	Peptidase M12B.|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		TGATGTTACGGATTCCGGAGA	0.338													30	81					0	0	0.000692331	0	0
BNIP2	663	broad.mit.edu	37	15	59964889	59964889	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:59964889G>A	uc010uhc.1	-	6	888	c.885C>T	c.(883-885)TTC>TTT	p.F295F	BNIP2_uc010uhb.1_Silent_p.F236F	NM_004330	NP_004321	Q12982	BNIP2_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 2	174	CRAL-TRIO.				anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			ovary(1)	1						TTTCAGGCATGAAACAGACAG	0.343													52	75					0	0	0.000781405	0	0
RORA	6095	broad.mit.edu	37	15	60806938	60806938	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:60806938G>A	uc002agv.2	-	5	556	c.400C>T	c.(400-402)CAG>TAG	p.Q134*	uc002ags.1_Intron|RORA_uc002agt.3_Nonsense_Mutation_p.Q46*|RORA_uc002agw.2_Nonsense_Mutation_p.Q126*|RORA_uc002agx.2_Nonsense_Mutation_p.Q101*	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	134	Nuclear receptor.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTGCTTTGCTGACTTCTCCTG	0.428													40	28					0	0	0.00222228	0	0
HERC1	8925	broad.mit.edu	37	15	64046743	64046743	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:64046743C>T	uc002amp.2	-	7	1883	c.1735G>A	c.(1735-1737)GAT>AAT	p.D579N	HERC1_uc010uil.1_Intron|HERC1_uc010bgt.1_Missense_Mutation_p.D579N	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	579					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GTTCTCCCATCTTTAGACAGA	0.348													30	42					0	0	0.0024448	0	0
ANKDD1A	348094	broad.mit.edu	37	15	65208001	65208001	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:65208001C>T	uc002aoa.2	+	2	69	c.40C>T	c.(40-42)CCT>TCT	p.P14S	ANKDD1A_uc002anx.1_Missense_Mutation_p.P14S|ANKDD1A_uc002any.2_5'UTR|ANKDD1A_uc002anz.2_Intron|ANKDD1A_uc002aob.2_5'UTR	NM_182703	NP_874362	Q495B1	AKD1A_HUMAN	ankyrin repeat and death domain containing 1A	14	ANK 1.				signal transduction					ovary(1)	1						CACAGTGCTTCCTCTGGAGAG	0.577													33	27					0	0	0.00128727	0	0
IGDCC3	9543	broad.mit.edu	37	15	65622704	65622704	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:65622704G>A	uc002aos.2	-	11	2037	c.1785C>T	c.(1783-1785)CTC>CTT	p.L595L	IGDCC3_uc002aor.1_5'Flank	NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	595	Extracellular (Potential).|Fibronectin type-III 2.									ovary(3)	3						GGTTGTAGGCGAGCAGCTTCA	0.612													38	73					0	0	0.00195071	0	0
MAP2K1	5604	broad.mit.edu	37	15	66727569	66727569	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:66727569C>T	uc010bhq.2	+	2	760	c.285C>T	c.(283-285)GCC>GCT	p.A95A	MAP2K1_uc010ujp.1_Silent_p.A73A	NM_002755	NP_002746	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	95	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity				0						TGGTCATGGCCAGAAAGGTGA	0.488									Cardiofaciocutaneous_syndrome				70	43					0	0	0.000781405	0	0
PAQR5	54852	broad.mit.edu	37	15	69695940	69695940	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:69695940C>T	uc002arz.2	+	9	1150	c.772C>T	c.(772-774)CAC>TAC	p.H258Y	PAQR5_uc002asa.2_Missense_Mutation_p.H258Y	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	258	Helical; Name=6; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						CCAGCTGTTTCACGTGTGTGT	0.398													32	26					0	0	0.000953801	0	0
UACA	55075	broad.mit.edu	37	15	70959686	70959686	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:70959686G>A	uc002asr.2	-	16	3441	c.3337C>T	c.(3337-3339)CCA>TCA	p.P1113S	UACA_uc010uke.1_Missense_Mutation_p.P1004S|UACA_uc002asq.2_Missense_Mutation_p.P1100S|UACA_uc010bin.1_Missense_Mutation_p.P1088S	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	1113	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						TGTTCCAATGGAACATGTTGT	0.373													48	94					0	0	0.000781405	0	0
LRRC49	54839	broad.mit.edu	37	15	71256254	71256254	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:71256254G>C	uc002asw.2	+	9	1151	c.904G>C	c.(904-906)GAT>CAT	p.D302H	LRRC49_uc002asu.2_Missense_Mutation_p.D292H|LRRC49_uc002asx.2_Missense_Mutation_p.D258H|LRRC49_uc010ukf.1_Missense_Mutation_p.D307H|LRRC49_uc002asy.2_Missense_Mutation_p.D8H|LRRC49_uc002asz.2_Missense_Mutation_p.D274H	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	302	LRRCT.					cytoplasm|microtubule				ovary(1)	1						GCGCCAGCTAGATATGAAGAG	0.438													27	48					0	0	0.00127121	0	0
CT62	196993	broad.mit.edu	37	15	71403623	71403623	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:71403623C>T	uc002ata.2	-	4	791	c.278G>A	c.(277-279)CGG>CAG	p.R93Q		NM_001102658	NP_001096128	P0C5K7	CT62_HUMAN	cancer/testis antigen 62	93											0						CTTGACATTCCGTCTGGAAAC	0.493													24	30					0	0	0.000586117	0	0
HEXA	3073	broad.mit.edu	37	15	72643516	72643516	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:72643516G>A	uc002aun.3	-	6	837	c.630C>T	c.(628-630)TCC>TCT	p.S210S	uc002aug.2_RNA|CELF6_uc002auk.3_Intron|HEXA_uc010ukn.1_Silent_p.S221S|HEXA_uc002auo.3_Silent_p.S73S|HEXA_uc010bix.2_Silent_p.S210S|HEXA_uc010biy.2_Silent_p.S73S|HEXA_uc010uko.1_Silent_p.S36S|HEXA_uc010biz.1_RNA	NM_000520	NP_000511	P06865	HEXA_HUMAN	hexosaminidase A preproprotein	210			S -> F (in GM2G1; infantile).		cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity			ovary(3)|upper_aerodigestive_tract(1)	4						CATATGGGAAGGAAGGATCAT	0.453													32	38					0	0	0.00058488	0	0
CD276	80381	broad.mit.edu	37	15	73996076	73996076	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:73996076C>T	uc002avv.1	+	5	1044	c.810C>T	c.(808-810)TTC>TTT	p.F270F	CD276_uc010bjd.1_Silent_p.F124F|CD276_uc002avu.1_Silent_p.F270F|CD276_uc002avw.1_Intron|CD276_uc010ulb.1_Silent_p.F216F|CD276_uc002avx.2_5'Flank	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	270	Ig-like V-type 2.|Extracellular (Potential).				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						GCTGCTCCTTCTCCCCCGAGC	0.672													23	10					0	0	0.000720815	0	0
C15orf59	388135	broad.mit.edu	37	15	74032412	74032412	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:74032412G>A	uc002avy.2	-	2	1073	c.728C>T	c.(727-729)TCT>TTT	p.S243F		NM_001039614	NP_001034703	Q2T9L4	CO059_HUMAN	hypothetical protein LOC388135	243										pancreas(1)	1						GGTCAGTGGAGAGCGCCGTGA	0.582													33	41					0	0	0.00178596	0	0
LMAN1L	79748	broad.mit.edu	37	15	75114199	75114199	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:75114199C>T	uc002ayt.1	+	10	1091	c.1089C>T	c.(1087-1089)TCC>TCT	p.S363S	LMAN1L_uc010bke.1_Silent_p.S351S	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	363	Lumenal (Potential).					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						AGATTCCATCCACCCCAGGGA	0.612													45	39					0	0	0.000781405	0	0
C15orf39	56905	broad.mit.edu	37	15	75500392	75500392	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:75500392C>A	uc002azp.3	+	2	2323	c.2003C>A	c.(2002-2004)CCG>CAG	p.P668Q	C15orf39_uc002azq.3_Missense_Mutation_p.P668Q|C15orf39_uc002azr.3_Missense_Mutation_p.P66Q	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	668											0						GCCGTGGTCCCGTCCACGCCC	0.607													31	67					2.08457e-15	7.14418e-15	0.00209593	1	0
MAN2C1	4123	broad.mit.edu	37	15	75648741	75648741	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:75648741G>A	uc002baf.2	-	24	2804	c.2787C>T	c.(2785-2787)TTC>TTT	p.F929F	MIR631_hsa-mir-631|MI0003645_5'Flank|MAN2C1_uc002bag.2_Intron|MAN2C1_uc002bah.2_Silent_p.F946F|MAN2C1_uc010bkk.2_Silent_p.F830F	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	929					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						CCAACAGGGGGAAGTTTAGGC	0.617													10	23					0	0	0.000978159	0	0
SIN3A	25942	broad.mit.edu	37	15	75692436	75692436	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:75692436G>A	uc002bai.2	-	12	2058	c.1799C>T	c.(1798-1800)TCC>TTC	p.S600F	SIN3A_uc002baj.2_Missense_Mutation_p.S600F|SIN3A_uc010uml.1_Missense_Mutation_p.S600F	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	600	Interactions with SUDS3 and SAP130.|Interaction with NCOR1 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						AGTCTTCTTGGAACTCACAAA	0.413													48	31					0	0	0.000680045	0	0
LOC645752	645752	broad.mit.edu	37	15	78208245	78208245	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:78208245C>T	uc010bky.2	-	15	1688	c.924G>A	c.(922-924)GAG>GAA	p.E308E	LOC645752_uc010umq.1_5'Flank|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CATCTGCCTTCTCCTTCGGGA	0.592													16	11					0	0	0.000958276	0	0
LOC645752	645752	broad.mit.edu	37	15	78208916	78208916	+	Missense_Mutation	SNP	C	G	G	rs56290535	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:78208916C>G	uc010bky.2	-	14	1581	c.817G>C	c.(817-819)GAA>CAA	p.E273Q	LOC645752_uc010umq.1_5'Flank|uc002bcw.1_5'Flank|uc002bcx.1_5'Flank	NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						TCCAGATGTTCTCCTCCATCT	0.627													4	82					0	0	0.000602214	0	0
ACSBG1	23205	broad.mit.edu	37	15	78475076	78475076	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:78475076G>A	uc002bdh.2	-	6	771	c.715C>T	c.(715-717)CCT>TCT	p.P239S	ACSBG1_uc010umw.1_Missense_Mutation_p.P235S|ACSBG1_uc010umx.1_5'UTR|ACSBG1_uc010umy.1_Missense_Mutation_p.P132S	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	239					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						TTGTTTGGAGGAGGTTCTTTA	0.517													58	61					0	0	0.000781405	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79064033	79064033	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:79064033C>T	uc002bej.3	-	15	2481	c.2270G>A	c.(2269-2271)TGG>TAG	p.W757*	ADAMTS7_uc010und.1_Intron|ADAMTS7_uc002bek.1_Nonsense_Mutation_p.W757*	NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	757	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GTCCCCGTTCCACTGGATGGT	0.627													14	21					0	0	0.00121646	0	0
TMC3	342125	broad.mit.edu	37	15	81637258	81637258	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:81637258G>A	uc002bgo.1	-	13	1367	c.1367C>T	c.(1366-1368)TCT>TTT	p.S456F	TMC3_uc010blr.1_RNA|TMC3_uc002bgp.2_Missense_Mutation_p.S456F	NM_001080532	NP_001074001	Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	456	Cytoplasmic (Potential).					integral to membrane				ovary(1)|liver(1)	2						TCCAGGCCGAGATGTGGACCA	0.478													13	14					0	0	0.000308642	0	0
EFTUD1	79631	broad.mit.edu	37	15	82444611	82444611	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:82444611G>A	uc002bgt.1	-	18	2353	c.2184C>T	c.(2182-2184)ATC>ATT	p.I728I	EFTUD1_uc002bgs.1_Silent_p.I99I|EFTUD1_uc002bgu.1_Silent_p.I677I	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	728					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						TTCCTTCAGGGATTTTGCTTT	0.433													54	114					0	0	0.000781405	0	0
AP3B2	8120	broad.mit.edu	37	15	83334244	83334244	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:83334244C>T	uc010uoh.1	-	16	2113	c.1936G>A	c.(1936-1938)GAG>AAG	p.E646K	AP3B2_uc010uoi.1_Missense_Mutation_p.E646K|AP3B2_uc010uoj.1_Missense_Mutation_p.E614K|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Missense_Mutation_p.E282K|AP3B2_uc002biy.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	646	Glu/Ser-rich.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			GGGGCTTCCTCCGGCCAGTCT	0.483													35	83					0	0	0.00148497	0	0
FSD2	123722	broad.mit.edu	37	15	83434727	83434727	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:83434727C>T	uc002bjd.2	-	10	1777	c.1610G>A	c.(1609-1611)AGC>AAC	p.S537N	FSD2_uc010uol.1_Missense_Mutation_p.S492N|FSD2_uc010uom.1_Missense_Mutation_p.S492N	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	537	Fibronectin type-III 2.									central_nervous_system(1)	1						GATAATGTAGCTCCGCCCCGG	0.607													15	8					0	0	0.000422831	0	0
ZNF592	9640	broad.mit.edu	37	15	85326229	85326229	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:85326229G>A	uc002bld.2	+	4	659	c.323G>A	c.(322-324)GGG>GAG	p.G108E	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	108					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CACAACTGTGGGAAATTTGAT	0.507													42	37					0	0	0.00170553	0	0
ALPK3	57538	broad.mit.edu	37	15	85402590	85402590	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:85402590G>A	uc002ble.2	+	7	4707	c.4540G>A	c.(4540-4542)GAT>AAT	p.D1514N		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1514	Ig-like 2.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ATGGGCCAAGGATCAGCGCCC	0.527													21	18					0	0	0.000586117	0	0
ALPK3	57538	broad.mit.edu	37	15	85411371	85411371	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:85411371C>T	uc002ble.2	+	14	5575	c.5408C>T	c.(5407-5409)CCT>CTT	p.P1803L	ALPK3_uc010upc.1_Missense_Mutation_p.P104L	NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1803	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			AGCTGCTTCCCTGCCCTGCTG	0.647													30	102					0	0	0.000692331	0	0
AGBL1	123624	broad.mit.edu	37	15	86807643	86807643	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:86807643C>T	uc002blz.1	+	10	1183	c.1103C>T	c.(1102-1104)TCC>TTC	p.S368F	AGBL1_uc002bma.1_Missense_Mutation_p.S99F|AGBL1_uc002bmb.1_Missense_Mutation_p.S62F	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	368					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GTCCAGACTTCCCTTCTGTGC	0.493													13	13					0	0	0.000308642	0	0
AGBL1	123624	broad.mit.edu	37	15	87217540	87217540	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:87217540G>A	uc002blz.1	+	22	3036	c.2956G>A	c.(2956-2958)GGA>AGA	p.G986R		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	986					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						GGAGGAGATGGGAGCCATGTT	0.517													7	11					0	0	0.000157383	0	0
NTRK3	4916	broad.mit.edu	37	15	88799275	88799275	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:88799275A>G	uc002bme.1	-	2	272	c.110T>C	c.(109-111)GTC>GCC	p.V37A	NTRK3_uc002bmh.2_Missense_Mutation_p.V37A|NTRK3_uc002bmf.1_Missense_Mutation_p.V37A|NTRK3_uc010bnh.1_Missense_Mutation_p.V37A|NTRK3_uc002bmg.2_Missense_Mutation_p.V37A	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	37	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTTGCTGCAGACACAATTTGC	0.572			T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			11	107					0	0	0.00185496	0	0
UNC45A	55898	broad.mit.edu	37	15	91486206	91486206	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:91486206C>T	uc002bqg.2	+	8	1261	c.921C>T	c.(919-921)GTC>GTT	p.V307V	UNC45A_uc002bqd.2_Silent_p.V292V	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	307					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			AGGTGGGGGTCTCTGGCCAAG	0.577													224	211					0	0	0.000781405	0	0
SV2B	9899	broad.mit.edu	37	15	91835678	91835679	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:91835678_91835679GG>TT	uc002bqv.2	+	12	2339_2340	c.1948_1949GG>TT	c.(1948-1950)GGG>TTG	p.G650L	SV2B_uc010uqv.1_Missense_Mutation_p.G499L|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	650	Extracellular (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TTCTTTTGTTGGGATAACCAAA	0.5													12	573					0	0	6.4e-05	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92706137	92706137	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:92706137C>T	uc002bqx.2	+	10	2106	c.1905C>T	c.(1903-1905)TCC>TCT	p.S635S	SLCO3A1_uc002bqy.2_Silent_p.S635S|SLCO3A1_uc002bqz.1_Silent_p.S577S	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	635	Helical; Name=12; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			CGCTCAAATCCTTCGCCTTCA	0.542													36	20					0	0	0.00195071	0	0
ARRDC4	91947	broad.mit.edu	37	15	98512549	98512549	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr15:98512549C>T	uc010bom.2	+	5	981	c.822C>T	c.(820-822)ATC>ATT	p.I274I	ARRDC4_uc002bui.3_Silent_p.I187I	NM_183376	NP_899232	Q8NCT1	ARRD4_HUMAN	arrestin domain containing 4	274					signal transduction						0	Melanoma(26;0.00539)|Lung NSC(78;0.0125)|all_lung(78;0.0222)		OV - Ovarian serous cystadenocarcinoma(32;0.0417)			CGCTAAAAATCCCACCTGTTA	0.433													37	24					0	0	0.00128727	0	0
ITFG3	83986	broad.mit.edu	37	16	304607	304607	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:304607C>T	uc002cgf.2	+	3	390	c.195C>T	c.(193-195)GTC>GTT	p.V65V	ITFG3_uc010bqr.2_Intron|ITFG3_uc002cgg.2_Silent_p.V65V|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Silent_p.V65V	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	65	Helical; Signal-anchor for type II membrane protein; (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				TGGTGTTCGTCGTCTCATTCG	0.597													154	97					0	0	0.000781405	0	0
PDIA2	64714	broad.mit.edu	37	16	336925	336925	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:336925G>A	uc002cgn.1	+	15	2621	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	PDIA2_uc010bqt.1_Missense_Mutation_p.E350K|PDIA2_uc002cgo.1_Missense_Mutation_p.E505K	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	505					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GCCCCCGGAGGAGCCAGCAGC	0.632													11	6					0	0	0.00185496	0	0
SOX8	30812	broad.mit.edu	37	16	1035151	1035151	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:1035151C>T	uc002ckn.2	+	3	1221	c.1106C>T	c.(1105-1107)CCG>CTG	p.P369L		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	369					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				AGCGCCAccccggccgccccc	0.617													12	4					0	0	0.00185496	0	0
CACNA1H	8912	broad.mit.edu	37	16	1245497	1245497	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:1245497G>A	uc002cks.2	+	4	725	c.477G>A	c.(475-477)GGG>GGA	p.G159G	CACNA1H_uc002ckt.2_Silent_p.G159G	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	159	I.|Helical; Name=S2 of repeat I; (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	TGGCCTTGGGGCTGTTCGGGC	0.607													6	8					0	0	0.00198382	0	0
CACNA1H	8912	broad.mit.edu	37	16	1262084	1262084	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:1262084G>A	uc002cks.2	+	25	4953	c.4705G>A	c.(4705-4707)GAG>AAG	p.E1569K	CACNA1H_uc002ckt.2_Missense_Mutation_p.E1569K|CACNA1H_uc002cku.2_Missense_Mutation_p.E275K|CACNA1H_uc010brj.2_Missense_Mutation_p.E275K|CACNA1H_uc002ckv.2_Missense_Mutation_p.E275K	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1569	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGAGGCGGAGGAGGCGCGGCG	0.667													27	52					0	0	0.000586117	0	0
UNKL	64718	broad.mit.edu	37	16	1453339	1453339	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:1453339G>A	uc010bro.1	-	3	302	c.294C>T	c.(292-294)CCC>CCT	p.P98P	UNKL_uc002clq.2_Silent_p.P98P	NM_001037125	NP_001032202	Q9H9P5	UNKL_HUMAN	unkempt homolog (Drosophila)-like isoform 2	98	C3H1-type 1.					cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding				0		Hepatocellular(780;0.0893)				GGTGCAGGTAGGGACACCTGG	0.617													9	16					0	0	0.000673444	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1818312	1818312	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:1818312C>T	uc002cmk.2	+	30	3792	c.3672C>T	c.(3670-3672)TCC>TCT	p.S1224S	MAPK8IP3_uc002cml.2_Silent_p.S1218S|MAPK8IP3_uc010uvl.1_Silent_p.S1225S	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	1224					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						CCTACTGCTCCATGGCCCAGG	0.662													31	66					0	0	0.00283554	0	0
TRAF7	84231	broad.mit.edu	37	16	2225900	2225900	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:2225900C>T	uc002cow.2	+	18	1791	c.1692C>T	c.(1690-1692)TCC>TCT	p.S564S		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	564	WD 5.				activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						GCGTCTACTCCATTGCTGTGA	0.572													30	16					0	0	0.00178596	0	0
ABCA3	21	broad.mit.edu	37	16	2331154	2331154	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:2331154G>A	uc002cpy.1	-	28	4945	c.4233C>T	c.(4231-4233)TGC>TGT	p.C1411C	ABCA3_uc010bsk.1_Silent_p.C1353C	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1411	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GCAGGCCGAAGCACTCCCCTT	0.627													16	41					0	0	0.000422831	0	0
ZG16B	124220	broad.mit.edu	37	16	2881806	2881806	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:2881806G>A	uc002cru.2	+	4	349	c.273G>A	c.(271-273)GTG>GTA	p.V91V		NM_145252	NP_660295	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16 homolog B precursor	91						extracellular region	sugar binding			ovary(1)	1						GTGTCCAGGTGAAACTTGGAG	0.552													31	30					0	0	0.00178596	0	0
PKMYT1	9088	broad.mit.edu	37	16	3023012	3023012	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:3023012G>A	uc002csn.2	-	9	1885	c.1442C>T	c.(1441-1443)CCC>CTC	p.P481L	PAQR4_uc002csj.3_3'UTR|PAQR4_uc002csk.3_3'UTR|PAQR4_uc002csl.3_3'UTR|PAQR4_uc010uwm.1_3'UTR|PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_3'UTR|PKMYT1_uc002cso.2_Missense_Mutation_p.P412L|PKMYT1_uc002csp.2_Missense_Mutation_p.P472L|PKMYT1_uc002csq.2_Missense_Mutation_p.P472L	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	481	Interaction with CDC2-CCNB1.|Interaction with PIN1.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						CTCAAAGGAGGGGAAGGAGCC	0.562													14	19					0	0	0.000566183	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3141587	3141587	+	Silent	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:3141587G>T	uc002ctv.1	-	4	664	c.576C>A	c.(574-576)ACC>ACA	p.T192T	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Silent_p.T110T|ZSCAN10_uc002ctx.1_Silent_p.T120T	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	192					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CATCCTCAAAGGTCAGGCACT	0.512													38	29					5.48756e-27	1.89032e-26	0.00285205	1	0
MEFV	4210	broad.mit.edu	37	16	3304424	3304424	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:3304424C>T	uc002cun.1	-	2	684	c.644G>A	c.(643-645)GGG>GAG	p.G215E		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	215					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	CCCCGCCAGCCCCTGCAGCCT	0.711													24	12					0	0	0.00047179	0	0
ZNF263	10127	broad.mit.edu	37	16	3339984	3339984	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:3339984C>T	uc002cuq.2	+	6	1810	c.1478C>T	c.(1477-1479)CCT>CTT	p.P493L	ZNF263_uc010uww.1_Missense_Mutation_p.P141L|ZNF263_uc002cur.2_Missense_Mutation_p.P141L	NM_005741	NP_005732	O14978	ZN263_HUMAN	zinc finger protein 263	493	C2H2-type 4.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(3)|ovary(1)	4						TACAAGTGCCCTGAGTGTGGG	0.522													7	27					0	0	0.000157383	0	0
ZNF597	146434	broad.mit.edu	37	16	3486990	3486991	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:3486990_3486991CC>TT	uc002cvd.2	-	4	892_893	c.708_709GG>AA	c.(706-711)AAGGAG>AAAAAG	p.E237K		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGGGCTTCTCCTTTACGTGGC	0.475													18	47					0	0	6.4e-05	0	0
NLRC3	197358	broad.mit.edu	37	16	3613900	3613900	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:3613900C>T	uc010btn.2	-	5	1449	c.1038G>A	c.(1036-1038)AGG>AGA	p.R346R		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	346	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						GGGGCCCCGTCCTGCTGCGCC	0.662													33	13					0	0	0.000814825	0	0
CORO7	79585	broad.mit.edu	37	16	4411374	4411374	+	Missense_Mutation	SNP	G	A	A	rs147901888		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:4411374G>A	uc002cwh.3	-	17	1795	c.1675C>T	c.(1675-1677)CGC>TGC	p.R559C	CORO7_uc002cwe.2_RNA|CORO7_uc002cwf.2_Missense_Mutation_p.R559C|CORO7_uc002cwg.3_Missense_Mutation_p.R339C|CORO7_uc010uxh.1_Missense_Mutation_p.R541C|CORO7_uc010uxi.1_Missense_Mutation_p.R474C|CORO7_uc002cwi.1_Missense_Mutation_p.R339C|CORO7_uc010uxj.1_RNA	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	559	WD 5.					cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						ACAGCGAGGCGATGGGGGTCA	0.667													16	48					0	0	0.000958276	0	0
UBN1	29855	broad.mit.edu	37	16	4910869	4910869	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:4910869C>T	uc002cyb.2	+	7	1215	c.876C>T	c.(874-876)CTC>CTT	p.L292L	UBN1_uc010uxw.1_Silent_p.L292L|UBN1_uc002cyc.2_Silent_p.L292L	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	292					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						TGCTCTCACTCTTTGGCTCTA	0.572													61	37					0	0	0.000781405	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857546	9857546	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:9857546C>T	uc002czo.3	-	13	4403	c.3855G>A	c.(3853-3855)AGG>AGA	p.R1285R	GRIN2A_uc010uym.1_Silent_p.R1285R|GRIN2A_uc010uyn.1_Intron|GRIN2A_uc002czr.3_Intron	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1285	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.R1285K(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GACGGCTAATCCTTAGCTTGT	0.532													22	57					0	0	0.00278032	0	0
GRIN2A	2903	broad.mit.edu	37	16	9916154	9916154	+	Missense_Mutation	SNP	C	T	T	rs143031592		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:9916154C>T	uc002czo.3	-	10	2683	c.2135G>A	c.(2134-2136)GGA>GAA	p.G712E	GRIN2A_uc010uym.1_Missense_Mutation_p.G712E|GRIN2A_uc010uyn.1_Missense_Mutation_p.G555E|GRIN2A_uc002czr.3_Missense_Mutation_p.G712E	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	712	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.G712E(1)		skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCCTCTACTCCTTTCTGATT	0.458													16	63					0	0	0.000566183	0	0
MKL2	57496	broad.mit.edu	37	16	14334138	14334138	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:14334138G>A	uc010uza.1	+	10	1031	c.876G>A	c.(874-876)AAG>AAA	p.K292K	MKL2_uc002dcg.2_Silent_p.K292K|MKL2_uc002dch.2_Silent_p.K281K|MKL2_uc010uzb.1_Silent_p.K241K	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	281					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						GTAGCAAAAAGTGCAAAGATC	0.383													50	20					0	0	0.000781405	0	0
KIAA0430	9665	broad.mit.edu	37	16	15702213	15702213	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:15702213G>A	uc002ddr.2	-	21	4310	c.4117C>T	c.(4117-4119)CGT>TGT	p.R1373C	KIAA0430_uc002ddq.2_Missense_Mutation_p.R1207C|KIAA0430_uc010uzv.1_Missense_Mutation_p.R1369C|KIAA0430_uc010uzw.1_Missense_Mutation_p.R1372C	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1372						peroxisome	nucleotide binding|RNA binding				0						TCTTGGAGACGAAATGTATAA	0.363													28	48					0	0	0.001512	0	0
NDE1	54820	broad.mit.edu	37	16	15790720	15790720	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:15790720C>T	uc002ddt.1	+	7	993	c.950C>T	c.(949-951)TCA>TTA	p.S317L	NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						GATAAGGGGTCAGTACCTTCT	0.582													10	18					0	0	0.000442599	0	0
MYH11	4629	broad.mit.edu	37	16	15815296	15815296	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:15815296C>T	uc002ddy.2	-	32	4668	c.4561G>A	c.(4561-4563)GAT>AAT	p.D1521N	MYH11_uc002ddv.2_Missense_Mutation_p.D1528N|MYH11_uc002ddw.2_Missense_Mutation_p.D1521N|MYH11_uc002ddx.2_Missense_Mutation_p.D1528N|MYH11_uc010bvg.2_Missense_Mutation_p.D1353N|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.D227N|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1521	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CCCACGTCATCCTTGGAGCTG	0.557			T	CBFB	AML								35	26					0	0	0.00111076	0	0
ABCC6	368	broad.mit.edu	37	16	16284023	16284023	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:16284023G>A	uc002den.3	-	12	1670	c.1633C>T	c.(1633-1635)CTG>TTG	p.L545L	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Silent_p.L557L	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	545	Helical; Name=10; (By similarity).|ABC transmembrane type-1 1.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GACGTCACCAGAAATGTAGAC	0.632													19	31					0	0	0.00229938	0	0
ABCC6	368	broad.mit.edu	37	16	16284205	16284205	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:16284205T>A	uc002den.3	-	12	1488	c.1451A>T	c.(1450-1452)AAG>ATG	p.K484M	ABCC6_uc010bvo.2_RNA|ABCC6_uc010uzz.1_Missense_Mutation_p.K496M	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	484	ABC transmembrane type-1 1.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCGTGAGTCCTTCTGCCTCAT	0.458													17	43					0	0	0.00121646	0	0
TMC5	79838	broad.mit.edu	37	16	19451763	19451763	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:19451763C>T	uc002dgc.3	+	3	1152	c.403C>T	c.(403-405)CCT>TCT	p.P135S	TMC5_uc010vaq.1_Missense_Mutation_p.P135S|TMC5_uc002dgb.3_Missense_Mutation_p.P135S|TMC5_uc010var.1_Missense_Mutation_p.P135S	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	135	Extracellular (Potential).					integral to membrane				skin(1)	1						TCAACGAAATCCTGATTTTGC	0.498													128	80					0	0	0.000781405	0	0
GPRC5B	51704	broad.mit.edu	37	16	19883558	19883558	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:19883558G>A	uc002dgt.2	-	2	718	c.610C>T	c.(610-612)CTC>TTC	p.L204F	GPRC5B_uc010vav.1_Missense_Mutation_p.L230F	NM_016235	NP_057319	Q9NZH0	GPC5B_HUMAN	G protein-coupled receptor, family C, group 5,	204	Helical; Name=5; (Potential).									lung(1)|breast(1)|skin(1)	3						TCGTAGATGAGGGCCATCACA	0.602													24	66					0	0	0.00106085	0	0
GPR139	124274	broad.mit.edu	37	16	20043243	20043243	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:20043243G>A	uc002dgu.1	-	2	1038	c.876C>T	c.(874-876)TTC>TTT	p.F292F	GPR139_uc010vaw.1_Silent_p.F199F	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	292	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						CCATGGTGCGGAACCGCTTGC	0.507													67	54					0	0	0.000781405	0	0
UMOD	7369	broad.mit.edu	37	16	20355393	20355394	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:20355393_20355394GG>AA	uc002dgz.2	-	6	1412_1413	c.1283_1284CC>TT	c.(1282-1284)CCC>CTT	p.P428L	UMOD_uc002dha.2_Missense_Mutation_p.P428L|UMOD_uc002dhb.2_Missense_Mutation_p.P461L	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	428	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						TCATGTCCAGGGGGTAGGAGCA	0.535													19	34					0	0	6.4e-05	0	0
ACSM5	54988	broad.mit.edu	37	16	20439149	20439149	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:20439149C>T	uc002dhe.2	+	7	1108	c.961C>T	c.(961-963)CCA>TCA	p.P321S		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	321					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CTGCTGTGTCCCAACCATCTT	0.468													90	65					0	0	0.000781405	0	0
ACSM5	54988	broad.mit.edu	37	16	20439153	20439153	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:20439153C>T	uc002dhe.2	+	7	1112	c.965C>T	c.(964-966)ACC>ATC	p.T322I		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	322					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TGTGTCCCAACCATCTTTCGG	0.473													53	102					0	0	0.000781405	0	0
ACSM2B	348158	broad.mit.edu	37	16	20548624	20548624	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:20548624G>A	uc002dhj.3	-	15	1900	c.1690C>T	c.(1690-1692)CGA>TGA	p.R564*	ACSM2B_uc002dhk.3_Nonsense_Mutation_p.R564*	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	564					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						TCCTTGTCTCGAAGTTTGGTT	0.463													113	86					0	0	0.000781405	0	0
DNAH3	55567	broad.mit.edu	37	16	21008666	21008666	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:21008666G>A	uc010vbe.1	-	44	6540	c.6540C>T	c.(6538-6540)ATC>ATT	p.I2180I		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2180	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GCATGTCCACGATGTCCAGCC	0.552													21	55					0	0	0.00152264	0	0
SCNN1G	6340	broad.mit.edu	37	16	23197754	23197754	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:23197754C>T	uc002dlm.1	+	2	301	c.162C>T	c.(160-162)CTC>CTT	p.L54L		NM_001039	NP_001030	P51170	SCNNG_HUMAN	sodium channel, nonvoltage-gated 1, gamma	54	Cytoplasmic (By similarity).				excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	TGCGCCGCCTCCTCTGGATCG	0.607													17	39					0	0	0.000958276	0	0
CACNG3	10368	broad.mit.edu	37	16	24358083	24358083	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:24358083C>T	uc002dmf.2	+	2	1440	c.240C>T	c.(238-240)ATC>ATT	p.I80I		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	80					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		GCAAGAAAATCGATCACTTCC	0.582													9	32					0	0	0.000274275	0	0
TNRC6A	27327	broad.mit.edu	37	16	24803029	24803029	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:24803029G>A	uc002dmm.2	+	6	3180	c.3066G>A	c.(3064-3066)TGG>TGA	p.W1022*	TNRC6A_uc010bxs.2_Nonsense_Mutation_p.W769*|TNRC6A_uc010vcc.1_Nonsense_Mutation_p.W769*|TNRC6A_uc002dmn.2_Nonsense_Mutation_p.W769*|TNRC6A_uc002dmo.2_Nonsense_Mutation_p.W769*	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1022	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TGAACATGTGGAACAAAAACG	0.458													19	35					0	0	0.00121646	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24942241	24942241	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:24942241G>A	uc002dnb.2	-	19	2472	c.2379C>T	c.(2377-2379)ACC>ACT	p.T793T	ARHGAP17_uc002dmx.2_Silent_p.T55T|ARHGAP17_uc002dmw.2_Silent_p.T55T|ARHGAP17_uc002dmy.2_Silent_p.T238T|ARHGAP17_uc002dmz.2_Silent_p.T317T|ARHGAP17_uc002dna.2_Silent_p.T520T|ARHGAP17_uc002dnc.2_Silent_p.T715T|ARHGAP17_uc010vcf.1_Silent_p.T536T|ARHGAP17_uc002dne.1_Silent_p.T55T	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	793	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		GTCTCGGTAAGGTTCCAGCAT	0.632													26	56					0	0	0.000720815	0	0
IL4R	3566	broad.mit.edu	37	16	27374181	27374181	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:27374181C>T	uc002don.2	+	11	1750	c.1508C>T	c.(1507-1509)TCC>TTC	p.S503F	IL4R_uc002dop.3_Missense_Mutation_p.S488F|IL4R_uc010bxy.2_Missense_Mutation_p.S503F|IL4R_uc002doo.2_Missense_Mutation_p.S343F	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	503	Cytoplasmic (Potential).|Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						TTCAGCAACTCCCTGAGCCAG	0.627													50	29					0	0	0.000781405	0	0
IL21R	50615	broad.mit.edu	37	16	27460449	27460449	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:27460449G>A	uc002doq.1	+	9	1695	c.1462G>A	c.(1462-1464)GAC>AAC	p.D488N	IL21R_uc002dor.1_Missense_Mutation_p.D488N|IL21R_uc002dos.1_Missense_Mutation_p.D488N|uc002dot.2_RNA	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	488	Cytoplasmic (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CCTGGATATGGACACGTTTGA	0.672			T	BCL6	NHL								14	38					0	0	0.000308642	0	0
GTF3C1	2975	broad.mit.edu	37	16	27549248	27549248	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:27549248C>T	uc002dov.1	-	4	649	c.609G>A	c.(607-609)AAG>AAA	p.K203K	GTF3C1_uc002dou.2_Silent_p.K203K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	203						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CAGCATCAACCCTGGAGGAAA	0.453													23	15					0	0	0.00229938	0	0
SULT1A1	6817	broad.mit.edu	37	16	28618163	28618163	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:28618163G>A	uc002dqi.2	-	5	986	c.513C>T	c.(511-513)TCC>TCT	p.S171S	uc010vct.1_Intron|SULT1A1_uc002dqj.2_Silent_p.S171S|SULT1A1_uc002dqk.2_Silent_p.S171S|SULT1A1_uc002dql.2_Silent_p.S171S|SULT1A1_uc002dqm.2_Silent_p.S93S|SULT1A1_uc002dqn.2_Silent_p.S262S|SULT1A1_uc002dqo.2_Silent_p.S171S|SULT1A1_uc002dqp.2_Silent_p.S171S	NM_177534	NP_803878	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A,	171					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						GCTGGTACCAGGATCCGTAGG	0.582													27	95					0	0	0.00058488	0	0
ATP2A1	487	broad.mit.edu	37	16	28914725	28914725	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:28914725G>A	uc002dro.1	+	21	3128	c.2944G>A	c.(2944-2946)GAA>AAA	p.E982K	uc010vct.1_Intron|ATP2A1_uc002drn.1_Missense_Mutation_p.E982K|ATP2A1_uc002drp.1_Missense_Mutation_p.E857K	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	982	Helical; Name=10; (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGGGCTCGACGAAATCCTCAA	0.577													21	70					0	0	0.00188189	0	0
RABEP2	79874	broad.mit.edu	37	16	28925884	28925884	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:28925884G>A	uc002drq.2	-	5	615	c.567C>T	c.(565-567)TCC>TCT	p.S189S	uc010vct.1_Intron|RABEP2_uc010vdf.1_Silent_p.S118S|RABEP2_uc010byn.2_Silent_p.S189S|RABEP2_uc002drr.2_Silent_p.S189S	NM_024816	NP_079092	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	189					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			ovary(1)|breast(1)|skin(1)	3						AGCCGTGCAGGGAAGGGGCAT	0.721													10	9					0	0	0.00136819	0	0
SPN	6693	broad.mit.edu	37	16	29675227	29675227	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:29675227G>A	uc002dtm.2	+	2	314	c.178G>A	c.(178-180)GAC>AAC	p.D60N	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.D60N|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	60	Extracellular (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						CAGCACTGGGGACCAGACCTC	0.552													71	41					0	0	0.000781405	0	0
SPN	6693	broad.mit.edu	37	16	29675345	29675345	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:29675345C>T	uc002dtm.2	+	2	432	c.296C>T	c.(295-297)TCC>TTC	p.S99F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.S99F|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	99	Extracellular (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						CAGGAAGTTTCCATCAAGATG	0.522													62	25					0	0	0.000781405	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29907160	29907160	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:29907160G>A	uc002duq.3	-	4	773	c.533C>T	c.(532-534)TCC>TTC	p.S178F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.S108F|SEZ6L2_uc002dur.3_Missense_Mutation_p.S108F|SEZ6L2_uc002dus.3_Intron|SEZ6L2_uc010vec.1_Missense_Mutation_p.S178F|SEZ6L2_uc010ved.1_Missense_Mutation_p.S134F	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	178	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TTCGCCCTCGGAGATGTTGTT	0.562													36	27					0	0	0.0025221	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29908237	29908237	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:29908237G>A	uc002duq.3	-	3	657	c.417C>T	c.(415-417)TCC>TCT	p.S139S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Intron|SEZ6L2_uc002dur.3_Intron|SEZ6L2_uc002dus.3_Silent_p.S139S|SEZ6L2_uc010vec.1_Silent_p.S139S|SEZ6L2_uc010ved.1_Silent_p.S95S	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	139	Pro-rich.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GAGGCCCTGGGGAGGCAGGGC	0.687													8	36					0	0	0.000442599	0	0
ZNF785	146540	broad.mit.edu	37	16	30594027	30594028	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:30594027_30594028GG>AA	uc002dyw.1	-	3	1149_1150	c.1071_1072CC>TT	c.(1069-1074)GCCCAT>GCTTAT	p.H358Y	uc002dyu.2_RNA|ZNF785_uc002dyv.1_Missense_Mutation_p.H343Y|ZNF785_uc010vez.1_Missense_Mutation_p.H323Y	NM_152458	NP_689671	A8K8V0	ZN785_HUMAN	zinc finger protein 785	358	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATCCACCGATGGGCTTCCAGGG	0.668													62	32					0	0	6.4e-05	0	0
STX1B	112755	broad.mit.edu	37	16	31004166	31004166	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:31004166G>A	uc010cad.2	-	10	955	c.843C>T	c.(841-843)TCC>TCT	p.S281S		NM_052874	NP_443106	P61266	STX1B_HUMAN	syntaxin 1B	281	Helical; Anchor for type IV membrane protein; (Potential).				intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity				0						TCCCCCCAATGGATGACGCCA	0.512													15	42					0	0	0.000958276	0	0
PRSS36	146547	broad.mit.edu	37	16	31157262	31157262	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:31157262G>A	uc002ebd.2	-	6	627	c.568C>T	c.(568-570)CCC>TCC	p.P190S	PRSS36_uc010vff.1_5'UTR|PRSS36_uc010vfg.1_Missense_Mutation_p.P190S|PRSS36_uc010vfh.1_Missense_Mutation_p.P190S	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	190	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						AGCACCCAGGGGAGAGGCAGA	0.597													14	8					0	0	0.000566183	0	0
ITGAX	3687	broad.mit.edu	37	16	31392265	31392265	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:31392265C>T	uc002ebu.1	+	29	3391	c.3324C>T	c.(3322-3324)CTC>CTT	p.L1108L	ITGAX_uc002ebt.2_Silent_p.L1108L	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1108	Helical; (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCACCCCCCTCATCGTAGGCA	0.547													35	35					0	0	0.00148497	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31484848	31484848	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:31484848C>T	uc002ecd.1	+	2	126	c.100C>T	c.(100-102)CCT>TCT	p.P34S	TGFB1I1_uc002ece.1_Missense_Mutation_p.P17S|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	34	Transcription activation (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						GCCTCTCACCCCTCCCCCATC	0.647													22	34					0	0	0.00229938	0	0
MYLK3	91807	broad.mit.edu	37	16	46781861	46781861	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:46781861G>A	uc002eei.3	-	1	361	c.245C>T	c.(244-246)CCC>CTC	p.P82L	MYLK3_uc010vge.1_Intron	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	82					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GTCAATGTGGGGAACCCCATC	0.706													7	19					0	0	0.00198382	0	0
ZNF423	23090	broad.mit.edu	37	16	49671869	49671869	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:49671869C>T	uc002efs.2	-	5	1492	c.1194G>A	c.(1192-1194)CGG>CGA	p.R398R	ZNF423_uc010vgn.1_Silent_p.R281R	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	398					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GCCCGTCATCCCGCATCTTCT	0.632													10	30					0	0	0.000978159	0	0
NOD2	64127	broad.mit.edu	37	16	50745127	50745127	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:50745127G>A	uc002egm.1	+	4	1410	c.1305G>A	c.(1303-1305)AGG>AGA	p.R435R	NOD2_uc010cbk.1_Silent_p.R408R|NOD2_uc002egl.1_Silent_p.R213R|NOD2_uc010cbl.1_Silent_p.R213R|NOD2_uc010cbm.1_Silent_p.R213R|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	435	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CGTTCCTCAGGAAGTACATCC	0.622													44	26					0	0	0.000781405	0	0
NOD2	64127	broad.mit.edu	37	16	50753891	50753891	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:50753891C>T	uc002egm.1	+	7	2791	c.2686C>T	c.(2686-2688)CGA>TGA	p.R896*	NOD2_uc010cbl.1_Nonsense_Mutation_p.R646*|NOD2_uc010cbm.1_Intron|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_Intron|NOD2_uc010cbp.1_Intron|NOD2_uc010cbq.1_Nonsense_Mutation_p.R34*|NOD2_uc010cbr.1_RNA|NOD2_uc010vgq.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	896					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				CGAGGGGCTCCGAGGCAACAC	0.597													70	41					0	0	0.000781405	0	0
TOX3	27324	broad.mit.edu	37	16	52497888	52497888	+	Silent	SNP	G	A	A	rs147213203	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:52497888G>A	uc002egw.2	-	3	537	c.366C>T	c.(364-366)CTC>CTT	p.L122L	TOX3_uc010vgt.1_Silent_p.L117L|TOX3_uc010vgu.1_Silent_p.L122L	NM_001080430	NP_001073899	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	122					apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity				0						CTTGTTCCACGAGATTTCTTG	0.433													67	52					0	0	0.000781405	0	0
CHD9	80205	broad.mit.edu	37	16	53352166	53352166	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:53352166C>T	uc002ehb.2	+	36	7791	c.7627C>T	c.(7627-7629)CGT>TGT	p.R2543C	CHD9_uc002egy.2_Missense_Mutation_p.R2527C|CHD9_uc002ehc.2_Missense_Mutation_p.R2528C|CHD9_uc002ehf.2_Missense_Mutation_p.R1641C|CHD9_uc010cbw.2_Missense_Mutation_p.R609C	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2543					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				AAAAAGACACCGTTGCAGAAA	0.333													15	27					0	0	0.000422831	0	0
Unknown	0	broad.mit.edu	37	16	53404789	53404789	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:53404789C>T	uc002ehh.2	-	1		c.94G>A								Homo sapiens mRNA; cDNA DKFZp313P036 (from clone DKFZp313P036).																		TTCCAATTTGCTGATATCAAA	0.413													9	33					0	0	0.000442599	0	0
NLRC5	84166	broad.mit.edu	37	16	57088686	57088686	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:57088686C>T	uc002ekk.1	+	25	3755	c.3530C>T	c.(3529-3531)CCG>CTG	p.P1177L	NLRC5_uc002ekn.2_Missense_Mutation_p.P896L|NLRC5_uc002ekl.2_Missense_Mutation_p.P982L|NLRC5_uc002ekm.2_Missense_Mutation_p.P952L|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Missense_Mutation_p.P93L|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Missense_Mutation_p.P93L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1177	LRR 12.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				GGACTGTCCCCGAAAAGCCCC	0.582													108	82					0	0	0.000781405	0	0
GPR114	221188	broad.mit.edu	37	16	57596024	57596024	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:57596024C>T	uc002elx.3	+	2	104	c.19C>T	c.(19-21)CTT>TTT	p.L7F	GPR114_uc010vhr.1_Missense_Mutation_p.L7F|GPR114_uc002ely.2_Missense_Mutation_p.L7F	NM_153837	NP_722579	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114 precursor	7					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)	1						CTGTGGTGCCCTTTTCCTGTG	0.527													21	55					0	0	0.00278032	0	0
CCDC113	29070	broad.mit.edu	37	16	58287928	58287928	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:58287928C>T	uc002ene.2	+	3	334	c.255C>T	c.(253-255)TCC>TCT	p.S85S	CCDC113_uc010vid.1_Intron	NM_014157	NP_054876	Q9H0I3	CC113_HUMAN	coiled-coil domain containing 113 isoform 1	85						protein complex					0						GATCCAAATCCCGGACAGGTA	0.488													33	31					0	0	0.000953801	0	0
CDH8	1006	broad.mit.edu	37	16	61854962	61854962	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:61854962C>T	uc002eog.1	-	6	1143	c.891G>A	c.(889-891)AGG>AGA	p.R297R	CDH8_uc002eoh.2_Silent_p.R66R	NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	297	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TGGCCTTCACCCTTCCTATTG	0.423													23	21					0	0	0.00278032	0	0
TK2	7084	broad.mit.edu	37	16	66565282	66565283	+	Splice_Site	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:66565282_66565283CC>TT	uc002eos.2	-	5	726	c.501_splice	c.e5+1	p.Q167_splice	TK2_uc010vip.1_Splice_Site_p.Q28_splice|TK2_uc002eor.2_Splice_Site_p.Q94_splice|TK2_uc010cdq.2_Splice_Site_p.Q94_splice|TK2_uc010cdr.2_Splice_Site_p.Q76_splice|TK2_uc010viq.1_Splice_Site_p.Q149_splice|TK2_uc010vir.1_Splice_Site_p.Q142_splice	NM_004614	NP_004605	O00142	KITM_HUMAN	thymidine kinase 2, mitochondrial						pyrimidine base metabolic process|pyrimidine nucleoside salvage	mitochondrial matrix	ATP binding|phosphotransferase activity, alcohol group as acceptor|thymidine kinase activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0736)|Epithelial(162;0.237)		CTGAAACCTACCTGAGGACGAG	0.515													5	26					0	0	6.4e-05	0	0
CA7	766	broad.mit.edu	37	16	66885423	66885423	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:66885423G>A	uc002eqi.2	+	4	524	c.415G>A	c.(415-417)GCA>ACA	p.A139T	uc002eqh.2_Intron|CA7_uc002eqj.2_Missense_Mutation_p.A83T	NM_005182	NP_005173	P43166	CAH7_HUMAN	carbonic anhydrase VII isoform 1	139					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GGCGGCCTCAGCACCTGATGG	0.587													123	67					0	0	0.000781405	0	0
DPEP3	64180	broad.mit.edu	37	16	68014061	68014061	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:68014061G>A	uc002evc.3	-	1	392	c.298C>T	c.(298-300)CCC>TCC	p.P100S	DPEP3_uc010cex.2_Missense_Mutation_p.P100S	NM_022357	NP_071752	Q9H4B8	DPEP3_HUMAN	dipeptidase 3 isoform a	75					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(3)	3		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		AGGGTTTTGGGGGTGCCTGGC	0.692													10	51					0	0	0.00136819	0	0
TMCO7	79613	broad.mit.edu	37	16	68934380	68934380	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:68934380C>T	uc002ewi.3	+	8	1433	c.1421C>T	c.(1420-1422)TCC>TTC	p.S474F		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	474	Helical; (Potential).					integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TTGATGGATTCCCTGCTTCCA	0.428													81	41					0	0	0.000781405	0	0
SF3B3	23450	broad.mit.edu	37	16	70588473	70588473	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:70588473C>T	uc002ezf.2	+	12	1738	c.1527C>T	c.(1525-1527)TCC>TCT	p.S509S		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	509					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TGTCCTGCTCCTTATTAGGAG	0.512													29	21					0	0	0.00209593	0	0
TAT	6898	broad.mit.edu	37	16	71604251	71604251	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:71604251G>A	uc002fap.2	-	9	1061	c.962C>T	c.(961-963)ACC>ATC	p.T321I		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	321					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CTGGACAATGGTACAGGGTCC	0.502													38	21					0	0	0.00128727	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170436	72170436	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:72170436C>T	uc002fcc.3	-	9	1286	c.1114G>A	c.(1114-1116)GAT>AAT	p.D372N	PMFBP1_uc002fcd.2_Missense_Mutation_p.D372N|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.D227N	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	372	Potential.									ovary(2)	2		Ovarian(137;0.179)				ATGTCCTTATCCTTCCTCTCA	0.552													57	31					0	0	0.000781405	0	0
PMFBP1	83449	broad.mit.edu	37	16	72184532	72184532	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:72184532C>T	uc002fcc.3	-	5	783	c.611G>A	c.(610-612)GGG>GAG	p.G204E	PMFBP1_uc002fcd.2_Missense_Mutation_p.G204E|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Missense_Mutation_p.G59E	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	204	Potential.									ovary(2)	2		Ovarian(137;0.179)				GCCGAGTTCCCCCTGCAACAT	0.527													47	106					0	0	0.000781405	0	0
ZFHX3	463	broad.mit.edu	37	16	72827203	72827203	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:72827203G>A	uc002fck.2	-	9	10051	c.9378C>T	c.(9376-9378)CTC>CTT	p.L3126L	ZFHX3_uc002fcl.2_Silent_p.L2212L	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3126					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TGAGGCCCGGGAGCAACACAG	0.562													26	75					0	0	0.000878237	0	0
ZFHX3	463	broad.mit.edu	37	16	72828002	72828002	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:72828002C>T	uc002fck.2	-	9	9252	c.8579G>A	c.(8578-8580)GGA>GAA	p.G2860E	ZFHX3_uc002fcl.2_Missense_Mutation_p.G1946E	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2860					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				AGTTGCTATTCCCGTTGCACT	0.488													38	96					0	0	0.00170553	0	0
ZFHX3	463	broad.mit.edu	37	16	72829102	72829102	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:72829102G>A	uc002fck.2	-	9	8152	c.7479C>T	c.(7477-7479)CCC>CCT	p.P2493P	ZFHX3_uc002fcl.2_Silent_p.P1579P	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2493					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				ACTGGGGTAAGGGGCACTGTG	0.637													40	22					0	0	0.00222228	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76481971	76481971	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:76481971C>T	uc002feu.1	+	7	986	c.601C>T	c.(601-603)CTG>TTG	p.L201L	CNTNAP4_uc002fev.1_Silent_p.L113L|CNTNAP4_uc010chb.1_Silent_p.L176L|CNTNAP4_uc002fex.1_Silent_p.L204L|CNTNAP4_uc002few.2_Silent_p.L176L	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	201	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TCAAAAATCCCTGAGCCCAAT	0.383													47	26					0	0	0.000781405	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76486500	76486500	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:76486500G>A	uc002feu.1	+	10	1552	c.1167G>A	c.(1165-1167)GAG>GAA	p.E389E	CNTNAP4_uc002fev.1_Silent_p.E253E|CNTNAP4_uc010chb.1_Silent_p.E316E|CNTNAP4_uc002fex.1_Silent_p.E392E|CNTNAP4_uc002few.2_Silent_p.E364E	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	389	Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TCTCTGGAGAGGAGGAGGTTT	0.463													16	74					0	0	0.000422831	0	0
CDYL2	124359	broad.mit.edu	37	16	80718715	80718715	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:80718715G>A	uc002ffs.2	-	2	441	c.336C>T	c.(334-336)CCC>CCT	p.P112P		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	112						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						GCTTGGCCAGGGGAGGGTTAA	0.547													14	29					0	0	0.00185496	0	0
LRRC50	123872	broad.mit.edu	37	16	84203607	84203607	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:84203607G>A	uc002fhl.3	+	8	1354	c.1173G>A	c.(1171-1173)CCG>CCA	p.P391P	LRRC50_uc010vnw.1_Silent_p.P155P	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	391	Pro-rich.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						AGCTCTGCCCGGAAAAGCCAA	0.582									Kartagener_syndrome				32	26					0	0	0.0024448	0	0
ATP2C2	9914	broad.mit.edu	37	16	84456106	84456106	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:84456106C>T	uc002fhx.2	+	8	824	c.735C>T	c.(733-735)ATC>ATT	p.I245I	ATP2C2_uc010chj.2_Silent_p.I245I|ATP2C2_uc002fhy.2_Silent_p.I262I|ATP2C2_uc002fhz.2_Silent_p.I94I	NM_014861	NP_055676	O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	245	Helical; Name=3; (Potential).				ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)	2						TCAGCAACATCGTCTTCATGG	0.602													45	24					0	0	0.000680045	0	0
KLHL36	79786	broad.mit.edu	37	16	84695403	84695403	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:84695403C>T	uc002fig.2	+	5	1656	c.1515C>T	c.(1513-1515)ATC>ATT	p.I505I	KLHL36_uc010chl.2_Silent_p.I441I|uc002fih.2_5'Flank	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	505	Kelch 5.									skin(2)	2						ATGACAACATCGAGTCCATGG	0.677													7	25					0	0	0.000157383	0	0
ZDHHC7	55625	broad.mit.edu	37	16	85010782	85010782	+	Silent	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:85010782C>A	uc002fiq.2	-	7	1022	c.669G>T	c.(667-669)CTG>CTT	p.L223L	ZDHHC7_uc010voi.1_Silent_p.L260L|ZDHHC7_uc002fir.1_RNA	NM_017740	NP_060210	Q9NXF8	ZDHC7_HUMAN	zinc finger, DHHC-type containing 7 isoform 2	223	Helical; (Potential).					integral to membrane	acyltransferase activity|protein binding|zinc ion binding			large_intestine(1)	1						CCTCAAGGCACAGGAAGATCA	0.468													28	53					3.1745e-13	1.08703e-12	0.001512	1	0
IRF8	3394	broad.mit.edu	37	16	85936699	85936699	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:85936699G>A	uc002fjh.2	+	2	135	c.78G>A	c.(76-78)CTG>CTA	p.L26L	IRF8_uc002fji.2_Silent_p.L26L	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	26	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				ATCCAGGACTGATTTGGGAGA	0.483													87	52					0	0	0.000781405	0	0
JPH3	57338	broad.mit.edu	37	16	87677874	87677874	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:87677874G>A	uc002fkd.2	+	2	647	c.393G>A	c.(391-393)CAG>CAA	p.Q131Q	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	131	MORN 6.|Gly-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GGACCTACCAGGGCCAGTGGG	0.667													41	22					0	0	0.000781405	0	0
JPH3	57338	broad.mit.edu	37	16	87678642	87678642	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:87678642G>A	uc002fkd.2	+	2	1414	c.1160_splice	c.e2+1	p.R387_splice	JPH3_uc010vou.1_Splice_Site	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3						calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CGGCTTCCAGGTAGGAGGGCG	0.672													10	7					0	0	0.00185496	0	0
KLHDC4	54758	broad.mit.edu	37	16	87788820	87788820	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:87788820G>A	uc002fki.2	-	4	395	c.349C>T	c.(349-351)CCG>TCG	p.P117S	KLHDC4_uc002fkj.2_Missense_Mutation_p.P117S|KLHDC4_uc002fkk.2_5'UTR|KLHDC4_uc002fkl.2_Missense_Mutation_p.P60S|KLHDC4_uc010chu.1_5'UTR	NM_017566	NP_060036	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	117	Kelch 1.									pancreas(2)	2				BRCA - Breast invasive adenocarcinoma(80;0.0283)		CAGCGCCTCGGAGGTGGACTG	0.507													14	44					0	0	0.000566183	0	0
ZC3H18	124245	broad.mit.edu	37	16	88688784	88688784	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:88688784C>T	uc002fky.2	+	9	1855	c.1655C>T	c.(1654-1656)TCT>TTT	p.S552F	ZC3H18_uc010voz.1_Missense_Mutation_p.S576F|ZC3H18_uc010chw.2_RNA	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	552	Ser-rich.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GCCTCTGCCTCTAATTCCTCC	0.617													8	10					0	0	0.000157383	0	0
MVD	4597	broad.mit.edu	37	16	88723906	88723906	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:88723906G>A	uc002flg.1	-	4	348	c.341C>T	c.(340-342)TCG>TTG	p.S114L	MVD_uc002flf.1_5'Flank	NM_002461	NP_002452	P53602	MVD1_HUMAN	diphosphomevalonate decarboxylase	114					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity				0				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GTTGTTCACCGATGCCACGTG	0.677													12	30					0	0	0.000308642	0	0
ANKRD11	29123	broad.mit.edu	37	16	89345505	89345505	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr16:89345505G>A	uc002fmx.1	-	9	7906	c.7445C>T	c.(7444-7446)CCG>CTG	p.P2482L	ANKRD11_uc002fmy.1_Missense_Mutation_p.P2482L|ANKRD11_uc002fnc.1_Missense_Mutation_p.P2482L|ANKRD11_uc002fna.1_Missense_Mutation_p.P147L|ANKRD11_uc002fnb.1_Missense_Mutation_p.P2439L	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	2482						nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CTTGCTGAGCGGCTTGCCGTC	0.657													5	29					0	0	0.00116845	0	0
SCARF1	8578	broad.mit.edu	37	17	1548500	1548500	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:1548500C>T	uc002fsz.1	-	2	185	c.135G>A	c.(133-135)TGG>TGA	p.W45*	SCARF1_uc002fsy.1_Nonsense_Mutation_p.W45*|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Nonsense_Mutation_p.W45*	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	45	Extracellular (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCTTCTGCCTCCAGCCTGCGC	0.622													93	3					0	0	0.000781405	0	0
RILP	83547	broad.mit.edu	37	17	1551726	1551726	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:1551726C>T	uc002ftd.2	-	5	1033	c.739G>A	c.(739-741)GAG>AAG	p.E247K	SCARF1_uc002fsy.1_5'Flank|SCARF1_uc002fsz.1_5'Flank|SCARF1_uc002fta.1_5'Flank|SCARF1_uc010cjv.1_5'Flank	NM_031430	NP_113618	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	247	RILP-like.				endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGCTCAAACTCCTCCCGACTG	0.632													111	7					0	0	0.000781405	0	0
RPA1	6117	broad.mit.edu	37	17	1747224	1747224	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:1747224C>T	uc002fto.2	+	3	210	c.95C>T	c.(94-96)CCC>CTC	p.P32L		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	32					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						AACATCCGTCCCATTACTACG	0.493								NER					128	7					0	0	0.000781405	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2901655	2901655	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:2901655G>A	uc010ckd.2	+	14	1275	c.1185G>A	c.(1183-1185)GAG>GAA	p.E395E	RAP1GAP2_uc010cke.2_Silent_p.E380E	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	395	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						CAGGCACAGAGACCCCATCCT	0.537													133	9					0	0	0.000781405	0	0
TRPV3	162514	broad.mit.edu	37	17	3424292	3424292	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:3424292G>A	uc002fvt.1	-	14	2107	c.1785C>T	c.(1783-1785)ATC>ATT	p.I595I	TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Silent_p.I579I|TRPV3_uc010vri.1_Silent_p.I550I|TRPV3_uc010vrj.1_Silent_p.I579I|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Silent_p.I579I|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Silent_p.I595I|TRPV3_uc002fvu.2_Silent_p.I595I|TRPV3_uc010vrn.1_3'UTR	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	595	Helical; (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	GCAAAAACACGATATATACAA	0.328													123	6					0	0	0.000781405	0	0
TRPV1	7442	broad.mit.edu	37	17	3477212	3477212	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:3477212G>A	uc010vrr.1	-	12	2345	c.1818C>T	c.(1816-1818)TCC>TCT	p.S606S	TRPV1_uc010vro.1_Silent_p.S617S|TRPV1_uc010vrp.1_Silent_p.S546S|TRPV1_uc010vrq.1_Silent_p.S604S|TRPV1_uc010vrs.1_Silent_p.S606S|TRPV1_uc010vrt.1_Silent_p.S606S|TRPV1_uc010vru.1_Silent_p.S606S	NM_080706	NP_542437	Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel,	606					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			ovary(1)	1				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	CAGACGGCAGGGAGTCATTCT	0.622													46	1					0	0	0.000781405	0	0
ATP2A3	489	broad.mit.edu	37	17	3853997	3853997	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:3853997G>A	uc002fxb.1	-	6	685	c.534C>T	c.(532-534)TCC>TCT	p.S178S	ATP2A3_uc002fwx.1_Silent_p.S178S|ATP2A3_uc002fwy.1_Silent_p.S178S|ATP2A3_uc002fwz.1_Silent_p.S178S|ATP2A3_uc002fxa.1_Silent_p.S178S|ATP2A3_uc002fxc.1_Silent_p.S178S|ATP2A3_uc002fxd.1_Silent_p.S178S	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	178	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCGTCAGGATGGACTGGTCCA	0.627													17	95					0	0	0.00188189	0	0
ZZEF1	23140	broad.mit.edu	37	17	3999944	3999945	+	Nonsense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:3999944_3999945CG>AT	uc002fxe.2	-	10	1786_1787	c.1722_1723CG>AT	c.(1720-1725)ACCGGA>ACATGA	p.G575*	ZZEF1_uc002fxk.1_Nonsense_Mutation_p.G575*	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	575							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GATTCAGTTCCGGTAGAAAAAA	0.342													9	409					0	0	6.4e-05	0	0
PLD2	5338	broad.mit.edu	37	17	4711584	4711584	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:4711584C>T	uc002fzc.2	+	4	357	c.256C>T	c.(256-258)CTG>TTG	p.L86L	PLD2_uc010vsj.1_5'UTR|PLD2_uc002fzd.2_Silent_p.L86L	NM_002663	NP_002654	O14939	PLD2_HUMAN	phospholipase D2	86	PX.				cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5					Choline(DB00122)	AACCTGCACTCTGTATTCTGT	0.562													44	382					0	0	0.000781405	0	0
MINK1	50488	broad.mit.edu	37	17	4789758	4789758	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:4789758C>T	uc010vsl.1	+	10	982	c.786C>T	c.(784-786)TTC>TTT	p.F262F	MINK1_uc010vsk.1_Silent_p.F262F|MINK1_uc010vsm.1_Silent_p.F262F|MINK1_uc010vsn.1_Silent_p.F262F|MINK1_uc010vso.1_Silent_p.F207F|MINK1_uc010vsp.1_5'UTR	NM_153827	NP_722549	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1 isoform 3	262	Protein kinase.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)|skin(1)	6						CTAAGAAGTTCATTGACTTCA	0.552													330	12					0	0	0.000781405	0	0
SPAG7	9552	broad.mit.edu	37	17	4863768	4863768	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:4863768G>A	uc002gae.2	-	3	261	c.228C>T	c.(226-228)ATC>ATT	p.I76I	SPAG7_uc002gad.2_Silent_p.I25I|SPAG7_uc002gaf.2_Silent_p.I76I	NM_004890	NP_004881	O75391	SPAG7_HUMAN	sperm associated antigen 7	76	R3H.					nucleus	nucleic acid binding|protein binding			ovary(1)|central_nervous_system(1)	2						TGCTCCTCTCGATCTTGTTCA	0.552													205	10					0	0	0.000781405	0	0
NLRP1	22861	broad.mit.edu	37	17	5418189	5418189	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:5418189C>T	uc002gci.2	-	17	4862	c.4307G>A	c.(4306-4308)TGG>TAG	p.W1436*	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Nonsense_Mutation_p.W1392*|NLRP1_uc002gcj.2_Nonsense_Mutation_p.W1406*|NLRP1_uc002gcl.2_Nonsense_Mutation_p.W1362*|NLRP1_uc002gch.3_Nonsense_Mutation_p.W1392*	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1436	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				CTTCCGGTCCCAGGACTGGCT	0.577													135	5					0	0	0.000781405	0	0
TEKT1	83659	broad.mit.edu	37	17	6704242	6704242	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:6704242G>A	uc002gdt.2	-	7	983	c.873C>T	c.(871-873)TCC>TCT	p.S291S	TEKT1_uc010vth.1_Silent_p.S145S	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	291	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				TTTTCTCCTGGGAAGCAATCT	0.502													280	5					0	0	0.000781405	0	0
SLC16A13	201232	broad.mit.edu	37	17	6942127	6942127	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:6942127G>T	uc002geh.2	+	3	1308	c.1000G>T	c.(1000-1002)GGG>TGG	p.G334W		NM_201566	NP_963860	Q7RTY0	MOT13_HUMAN	monocarboxylate transporter 13	334	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(1)|skin(1)	2						TGAACTAATAGGGACTAGAAG	0.602													11	349					1.49906e-05	5.09213e-05	0.00244969	1	0
ACAP1	9744	broad.mit.edu	37	17	7250233	7250233	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:7250233C>T	uc002ggd.2	+	13	1320	c.1114C>T	c.(1114-1116)CCC>TCC	p.P372S		NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	372	Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						TGATGACAGCCCCCGGGGTCC	0.637													67	8					0	0	0.000781405	0	0
TNK1	8711	broad.mit.edu	37	17	7287889	7287889	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:7287889C>T	uc002ggi.3	+	7	1113	c.953C>T	c.(952-954)TCC>TTC	p.S318F	TNK1_uc002ggj.3_Missense_Mutation_p.S318F|TNK1_uc010cmf.2_RNA|TNK1_uc002ggk.3_5'Flank	NM_003985	NP_003976	Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	318	Protein kinase.				protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(122;0.157)				GAGATGTTCTCCGGGGGCGAG	0.682													19	2					0	0	0.00188189	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			49	8					0	0	0.000781405	0	0
WRAP53	55135	broad.mit.edu	37	17	7605064	7605064	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:7605064C>T	uc010vuh.1	+	7	1067	c.912C>T	c.(910-912)TCC>TCT	p.S304S	WRAP53_uc010vui.1_Silent_p.S304S|WRAP53_uc002gip.2_Silent_p.S304S|WRAP53_uc002gir.2_Silent_p.S304S|WRAP53_uc002giq.2_RNA|WRAP53_uc010cnl.2_Silent_p.S271S|WRAP53_uc010vuj.1_Silent_p.S85S	NM_001143990	NP_001137462	Q9BUR4	WAP53_HUMAN	WD repeat domain 79 isoform 2	304	WD 3.				positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding				0						GTGTTTTTTCCACGGCCCGGC	0.627													53	6					0	0	0.000781405	0	0
DNAH2	146754	broad.mit.edu	37	17	7662770	7662770	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:7662770C>T	uc002giu.1	+	15	2493	c.2479C>T	c.(2479-2481)CGG>TGG	p.R827W		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	827	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				GTACATGATTCGGCTGGACCG	0.522													77	10					0	0	0.000781405	0	0
CHD3	1107	broad.mit.edu	37	17	7801392	7801392	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:7801392G>A	uc002gje.2	+	12	2173	c.2023G>A	c.(2023-2025)GAA>AAA	p.E675K	CHD3_uc002gjd.2_Missense_Mutation_p.E734K|CHD3_uc002gjf.2_Missense_Mutation_p.E675K|CHD3_uc002gjg.1_Missense_Mutation_p.E503K	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	675					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TGAATACGAAGAACATAAGCA	0.438													143	23					0	0	0.000781405	0	0
C17orf68	80169	broad.mit.edu	37	17	8137885	8137886	+	Missense_Mutation	DNP	GG	AC	AC			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:8137885_8137886GG>AC	uc002gkq.3	-	10	1764_1765	c.1705_1706CC>GT	c.(1705-1707)CCT>GTT	p.P569V	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	569					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						AAGGGCCTTAGGGTCAAAGGAG	0.634													13	2					0	0	6.4e-05	0	0
PIK3R5	23533	broad.mit.edu	37	17	8814745	8814745	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:8814745C>T	uc002glt.2	-	2	134	c.67G>A	c.(67-69)GGA>AGA	p.G23R	PIK3R5_uc010vuz.1_Missense_Mutation_p.G23R|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Missense_Mutation_p.G23R|PIK3R5_uc010cob.1_Intron	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	23					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AGGCTGAGTCCATGCAGGCAG	0.682													87	7					0	0	0.000781405	0	0
MYH1	4619	broad.mit.edu	37	17	10408556	10408556	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:10408556G>A	uc002gmo.2	-	21	2453	c.2359C>T	c.(2359-2361)CAG>TAG	p.Q787*	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	787	IQ.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GTAATCAGCTGGGCCAGCTTC	0.438													80	4					0	0	0.000781405	0	0
MYH3	4621	broad.mit.edu	37	17	10551946	10551946	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:10551946G>A	uc002gmq.1	-	7	740	c.663C>T	c.(661-663)ATC>ATT	p.I221I		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	221	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TGGCACTGATGATTTGATCTT	0.363													100	6					0	0	0.000781405	0	0
RICH2	9912	broad.mit.edu	37	17	12823137	12823137	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:12823137C>T	uc002gnr.3	+	6	780	c.453C>T	c.(451-453)TCC>TCT	p.S151S	RICH2_uc010vvk.1_Silent_p.S151S|RICH2_uc010vvl.1_Silent_p.S151S|RICH2_uc002gns.3_5'UTR|RICH2_uc010vvm.1_Silent_p.S151S|RICH2_uc010vvn.1_RNA	NM_014859	NP_055674	Q17R89	RHG44_HUMAN	Rho GTPase-activating protein RICH2	151	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						ACATGGATTCCTCACGAACCA	0.388													26	0					0	0	0.00106085	0	0
CDRT15P	94158	broad.mit.edu	37	17	13928350	13928350	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:13928350G>A	uc002god.1	+	1		c.536G>A				NR_003261				Homo sapiens CMT1A duplicated region transcript 15 pseudogene (CDRT15P), non-coding RNA.												0						TCCAGCCAAGGACCAGACCAA	0.602													43	3					0	0	0.000781405	0	0
NCOR1	9611	broad.mit.edu	37	17	16062165	16062165	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:16062165G>A	uc002gpo.2	-	6	881	c.641C>T	c.(640-642)GCT>GTT	p.A214V	NCOR1_uc002gpn.2_Missense_Mutation_p.A214V|NCOR1_uc002gpp.1_Missense_Mutation_p.A105V|NCOR1_uc002gpr.2_Missense_Mutation_p.A105V|NCOR1_uc002gps.1_Missense_Mutation_p.A214V|NCOR1_uc010coz.1_Missense_Mutation_p.A30V|NCOR1_uc010cpb.1_Missense_Mutation_p.A214V|NCOR1_uc010cpa.1_Missense_Mutation_p.A214V	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	214	Potential.|Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGGAGGTTTAGCTGCCTCTTC	0.483													27	5					0	0	0.000878237	0	0
CCDC144A	9720	broad.mit.edu	37	17	16593811	16593811	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:16593811G>A	uc002gqk.1	+	1	173	c.97G>A	c.(97-99)GGG>AGG	p.G33R		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	33											0						CGGGAGCCAGGGGGACCAGTG	0.657													21	3					0	0	0.00152264	0	0
MYO15A	51168	broad.mit.edu	37	17	18023906	18023906	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:18023906G>A	uc010vxh.1	+	2	2130	c.1792G>A	c.(1792-1794)GGC>AGC	p.G598S		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	598	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					GGCCCGGGCGGGCGGCCCTGC	0.697													7	3					0	0	0.000673444	0	0
ULK2	9706	broad.mit.edu	37	17	19680995	19680995	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:19680995T>G	uc002gwm.3	-	26	3460	c.2951A>C	c.(2950-2952)CAG>CCG	p.Q984P	ULK2_uc002gwn.2_Missense_Mutation_p.Q984P	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	984					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					ATCTTCGGTCTGCTGAAACAT	0.408													13	4					0	0	0.00185496	0	0
Unknown	0	broad.mit.edu	37	17	21731254	21731254	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:21731254G>A	uc002gyy.3	+	2	681	c.556G>A	c.(556-558)GAA>AAA	p.E186K						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;																		CCAAGATAAAGAAGGCATCCC	0.527													28	7					0	0	0.001512	0	0
SARM1	23098	broad.mit.edu	37	17	26687798	26687798	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:26687798C>T	uc010wah.1	+	5	466	c.459C>T	c.(457-459)TTC>TTT	p.F153F	TMEM199_uc002hba.2_Silent_p.F153F	NM_152464	NP_689677	Q6SZW1	SARM1_HUMAN	transmembrane protein 199	Error:Variant_position_missing_in_Q6SZW1_after_alignment					innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TCTTCAATTTCATTGTCACGG	0.502													62	7					0	0	0.000781405	0	0
SUPT6H	6830	broad.mit.edu	37	17	27015132	27015132	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:27015132G>A	uc002hby.2	+	24	3120	c.3030G>A	c.(3028-3030)CGG>CGA	p.R1010R	SUPT6H_uc010crt.2_Silent_p.R1010R|SUPT6H_uc002hbz.1_5'Flank	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	1010					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					ACAACACCCGGCTCGAGAGCC	0.592													48	3					0	0	0.000781405	0	0
PLXDC1	57125	broad.mit.edu	37	17	37234198	37234198	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:37234198G>A	uc002hrg.2	-	11	1366	c.1154C>T	c.(1153-1155)TCC>TTC	p.S385F	uc002hre.1_Intron|uc002hrf.1_Intron|PLXDC1_uc010cvr.1_Missense_Mutation_p.S93F|PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	385	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						GAAGAGGGAGGAGGAGGTAGT	0.607													43	5					0	0	0.000781405	0	0
WIPF2	147179	broad.mit.edu	37	17	38421226	38421226	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:38421226T>C	uc002hug.1	+	5	1038	c.798T>C	c.(796-798)TCT>TCC	p.S266S	WIPF2_uc002huh.1_Silent_p.S116S|WIPF2_uc010cww.1_Silent_p.S116S|WIPF2_uc002hui.1_Silent_p.S266S|WIPF2_uc010cwx.1_Intron|WIPF2_uc010cwy.1_Silent_p.S266S	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	266						cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						ATGGACCCTCTAGCCCCACTA	0.592										HNSCC(43;0.11)			104	9					0	0	0.000781405	0	0
TNS4	84951	broad.mit.edu	37	17	38652406	38652407	+	Missense_Mutation	DNP	GG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:38652406_38652407GG>AT	uc010cxb.2	-	2	435_436	c.271_272CC>AT	c.(271-273)CCA>ATA	p.P91I		NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	91					apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			AAGGTCCTCTGGGGTCCCCAAG	0.634													53	7					0	0	6.4e-05	0	0
KRT27	342574	broad.mit.edu	37	17	38936698	38936698	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:38936698C>T	uc002hvg.2	-	3	579	c.538G>A	c.(538-540)GAG>AAG	p.E180K		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	180	Rod.|Coil 1B.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				AGCGCTAGCTCGTTTTCAAAC	0.453													7	24					0	0	0.00198382	0	0
KRT10	3858	broad.mit.edu	37	17	38975396	38975396	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:38975396C>A	uc002hvi.2	-	7	1417	c.1391G>T	c.(1390-1392)CGC>CTC	p.R464L	KRT10_uc010cxd.2_Intron|TMEM99_uc002hvj.1_5'UTR	NM_000421	NP_000412	P13645	K1C10_HUMAN	keratin 10	464	Gly-rich.|Tail.				epidermis development		protein binding|structural constituent of epidermis				0		Breast(137;0.000301)				tccgccgccgcgtccgccgcc	0.184													7	6					2.0095e-06	6.83466e-06	0.00198382	1	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39262217	39262217	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:39262217A>G	uc010wfp.1	+	1	577	c.577A>G	c.(577-579)ACC>GCC	p.T193A		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	193						keratin filament					0						CTATCGCCCAACCTGTGTCAT	0.483													3	5					0	0	0.000602214	0	0
KRT16	3868	broad.mit.edu	37	17	39768789	39768789	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:39768789G>A	uc002hxg.3	-	1	291	c.152C>T	c.(151-153)TCT>TTT	p.S51F	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	51	Head.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				AGAGGAGACAGACAGGCCGCC	0.657													8	2					0	0	0.000157383	0	0
Unknown	0	broad.mit.edu	37	17	40180127	40180127	+	Missense_Mutation	SNP	G	A	A	rs147945853		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:40180127G>A	uc002hyu.2	-	2	261	c.118C>T	c.(118-120)CCT>TCT	p.P40S						RecName: Full=Zinc finger protein 385C;																		TGGAAGGCAGGGCTGGGCCCC	0.682													53	3					0	0	0.000781405	0	0
STAT5B	6777	broad.mit.edu	37	17	40370323	40370323	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:40370323G>A	uc002hzh.2	-	9	1184	c.1015C>T	c.(1015-1017)CCT>TCT	p.P339S	STAT5B_uc002hzi.3_Missense_Mutation_p.P339S	NM_012448	NP_036580	P51692	STA5B_HUMAN	signal transducer and activator of transcription	339					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			ovary(3)|lung(2)|skin(1)	6		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	AGGACCTGAGGAGGCTGCTTC	0.612													16	66					0	0	0.000958276	0	0
BRCA1	672	broad.mit.edu	37	17	41246107	41246107	+	Silent	SNP	G	A	A	rs80357778		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:41246107G>A	uc002icq.2	-	10	1673	c.1441C>T	c.(1441-1443)CTA>TTA	p.L481L	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Silent_p.L410L|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Silent_p.L434L|BRCA1_uc002ict.2_Silent_p.L481L|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Silent_p.L481L|BRCA1_uc002ide.1_Silent_p.L312L|BRCA1_uc010cyy.1_Silent_p.L481L|BRCA1_uc010whs.1_Silent_p.L481L|BRCA1_uc010cyz.2_Silent_p.L434L|BRCA1_uc010cza.2_Silent_p.L455L|BRCA1_uc010wht.1_Silent_p.L185L	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	481					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		CCTATAATTAGATTTTCAGTT	0.393			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			40	100					0	0	0.000680045	0	0
PPY	5539	broad.mit.edu	37	17	42018914	42018914	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:42018914G>A	uc002iep.2	-	2	154	c.109C>T	c.(109-111)CCA>TCA	p.P37S		NM_002722	NP_002713	P01298	PAHO_HUMAN	pancreatic polypeptide preproprotein	37					digestion|protein secretion	extracellular region	hormone activity				0		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TTGTCCCCTGGGTACACTGGC	0.612													17	51					0	0	0.000566183	0	0
FZD2	2535	broad.mit.edu	37	17	42636136	42636136	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:42636136G>A	uc002igx.1	+	1	1212	c.1080G>A	c.(1078-1080)TGG>TGA	p.W360*		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	360	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCATGAAGTGGGGCCACGAGG	0.622													50	34					0	0	0.000781405	0	0
EFTUD2	9343	broad.mit.edu	37	17	42962668	42962668	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:42962668G>A	uc002ihn.2	-	4	567	c.306C>T	c.(304-306)TTC>TTT	p.F102F	EFTUD2_uc010wje.1_Silent_p.F67F|EFTUD2_uc010wjf.1_Silent_p.F102F	NM_004247	NP_004238	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain	102						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(33;0.109)				CCATCAGAGTGAATTTCTTGG	0.383													63	140					0	0	0.000781405	0	0
KIF18B	146909	broad.mit.edu	37	17	43003827	43003827	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:43003827G>A	uc010wji.1	-	15	2517	c.2416C>T	c.(2416-2418)CCC>TCC	p.P806S	KIF18B_uc002iht.2_Missense_Mutation_p.P815S|KIF18B_uc010wjh.1_Missense_Mutation_p.P803S	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				GTGCTGCTGGGGAGGCGGGCG	0.622													9	3					0	0	0.00136819	0	0
KIAA1267	284058	broad.mit.edu	37	17	44144014	44144014	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:44144014G>A	uc002ikb.2	-	5	1822	c.1737C>T	c.(1735-1737)CTC>CTT	p.L579L	KIAA1267_uc002ikc.2_Silent_p.L579L|KIAA1267_uc002ikd.2_Silent_p.L579L|KIAA1267_uc010dav.2_Silent_p.L579L	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	579						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				ATGAAGAGACGAGATTCAGTC	0.517													15	29					0	0	0.00074312	0	0
WNT3	7473	broad.mit.edu	37	17	44845943	44845944	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:44845943_44845944CC>TT	uc002ikv.2	-	4	929_930	c.810_811GG>AA	c.(808-813)ACGGAG>ACAAAG	p.E271K		NM_030753	NP_110380	P56703	WNT3_HUMAN	wingless-type MMTV integration site family,	271					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			AGGTCCCTCTCCGTGGGTGGCT	0.589													18	60					0	0	6.4e-05	0	0
CDK5RAP3	80279	broad.mit.edu	37	17	46057967	46057967	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:46057967C>T	uc002imr.2	+	12	1170	c.1086C>T	c.(1084-1086)ATC>ATT	p.I362I	CDK5RAP3_uc010wlc.1_Silent_p.I382I|CDK5RAP3_uc002imq.1_Silent_p.I137I|CDK5RAP3_uc002imu.2_Silent_p.I206I|CDK5RAP3_uc002ims.2_Silent_p.I275I|CDK5RAP3_uc002imv.2_Silent_p.I206I|CDK5RAP3_uc002imw.2_Silent_p.I204I|CDK5RAP3_uc002imx.2_Silent_p.I137I	NM_176096	NP_788276	Q96JB5	CK5P3_HUMAN	CDK5 regulatory subunit associated protein 3	362					brain development|regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation		neuronal Cdc2-like kinase binding				0						AGCTTGAGATCTTCTTAGCCC	0.363													64	175					0	0	0.000781405	0	0
HOXB8	3218	broad.mit.edu	37	17	46690746	46690746	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:46690746C>T	uc002inw.2	-	2	785	c.550G>A	c.(550-552)GGA>AGA	p.G184R	HOXB7_uc002inv.2_5'Flank	NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	184	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTGTCAGTCCCAGGGCGTGC	0.512													28	62					0	0	0.0024448	0	0
HOXB8	3218	broad.mit.edu	37	17	46691711	46691711	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:46691711C>T	uc002inw.2	-	1	591	c.356G>A	c.(355-357)GGC>GAC	p.G119D		NM_024016	NP_076921	P17481	HXB8_HUMAN	homeobox B8	119						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCCTCCTCGCCCAGGCCGCT	0.692													4	11					0	0	0.00024832	0	0
SGCA	6442	broad.mit.edu	37	17	48244740	48244740	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:48244740G>A	uc002iqi.2	+	2	85	c.49G>A	c.(49-51)GGG>AGG	p.G17R	SGCA_uc010wmh.1_5'UTR|SGCA_uc002iqj.2_Missense_Mutation_p.G17R|SGCA_uc010wmi.1_RNA	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	17					muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						TCTCCTGGCAGGGCTGGGGGA	0.617													23	30					0	0	0.000586117	0	0
SGCA	6442	broad.mit.edu	37	17	48245361	48245361	+	Silent	SNP	G	A	A	rs147739328	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:48245361G>A	uc002iqi.2	+	4	402	c.366G>A	c.(364-366)CTG>CTA	p.L122L	SGCA_uc010wmh.1_Silent_p.L20L|SGCA_uc002iqj.2_Silent_p.L122L|SGCA_uc010wmi.1_RNA	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	122	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						GGCTGGTGCTGGAGATTGGGG	0.592													46	29					0	0	0.000781405	0	0
RSAD1	55316	broad.mit.edu	37	17	48562205	48562205	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:48562205C>T	uc002iqw.1	+	9	1368	c.1312C>T	c.(1312-1314)CCT>TCT	p.P438S	RSAD1_uc010wmq.1_RNA	NM_018346	NP_060816	Q9HA92	RSAD1_HUMAN	radical S-adenosyl methionine domain containing	438					porphyrin biosynthetic process	mitochondrion	4 iron, 4 sulfur cluster binding|coproporphyrinogen oxidase activity|metal ion binding				0	Breast(11;1.93e-18)		BRCA - Breast invasive adenocarcinoma(22;1.55e-09)			AACCCCCTCCCCTGTGCCAGG	0.577													15	11					0	0	0.000422831	0	0
CACNA1G	8913	broad.mit.edu	37	17	48668851	48668851	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:48668851C>T	uc002irk.1	+	11	2881	c.2509C>T	c.(2509-2511)CGC>TGC	p.R837C	CACNA1G_uc002iri.1_Missense_Mutation_p.R837C|CACNA1G_uc002irj.1_Missense_Mutation_p.R837C|CACNA1G_uc002irl.1_Missense_Mutation_p.R837C|CACNA1G_uc002irm.1_Missense_Mutation_p.R837C|CACNA1G_uc002irn.1_Missense_Mutation_p.R837C|CACNA1G_uc002iro.1_Missense_Mutation_p.R837C|CACNA1G_uc002irp.1_Missense_Mutation_p.R837C|CACNA1G_uc002irq.1_Missense_Mutation_p.R837C|CACNA1G_uc002irr.1_Missense_Mutation_p.R837C|CACNA1G_uc002irs.1_Missense_Mutation_p.R837C|CACNA1G_uc002irt.1_Missense_Mutation_p.R837C|CACNA1G_uc002irv.1_Missense_Mutation_p.R837C|CACNA1G_uc002irw.1_Missense_Mutation_p.R837C|CACNA1G_uc002iru.1_Missense_Mutation_p.R837C|CACNA1G_uc002irx.1_Missense_Mutation_p.R750C|CACNA1G_uc002iry.1_Missense_Mutation_p.R750C|CACNA1G_uc002irz.1_Missense_Mutation_p.R750C|CACNA1G_uc002isa.1_Missense_Mutation_p.R750C|CACNA1G_uc002isb.1_Missense_Mutation_p.R750C|CACNA1G_uc002isc.1_Missense_Mutation_p.R750C|CACNA1G_uc002isd.1_Missense_Mutation_p.R750C|CACNA1G_uc002ise.1_Missense_Mutation_p.R750C|CACNA1G_uc002isf.1_Missense_Mutation_p.R750C|CACNA1G_uc002isg.1_Missense_Mutation_p.R750C|CACNA1G_uc002ish.1_Missense_Mutation_p.R750C|CACNA1G_uc002isi.1_Missense_Mutation_p.R750C	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	837	Helical; Name=S4 of repeat II; (Potential).|II.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCGGACCTTCCGCCTGATGCG	0.672													7	6					0	0	0.00198382	0	0
CACNA1G	8913	broad.mit.edu	37	17	48703397	48703398	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:48703397_48703398CC>TT	uc002irk.1	+	38	6791_6792	c.6419_6420CC>TT	c.(6418-6420)TCC>TTT	p.S2140F	CACNA1G_uc002irj.1_Missense_Mutation_p.S2013F|CACNA1G_uc002irl.1_Missense_Mutation_p.S2024F|CACNA1G_uc002irm.1_Missense_Mutation_p.S2061F|CACNA1G_uc002irn.1_Missense_Mutation_p.S2006F|CACNA1G_uc002iro.1_Missense_Mutation_p.S2013F|CACNA1G_uc002irp.1_Missense_Mutation_p.S2095F|CACNA1G_uc002irq.1_Missense_Mutation_p.S2117F|CACNA1G_uc002irr.1_Missense_Mutation_p.S2047F|CACNA1G_uc002irs.1_Missense_Mutation_p.S2084F|CACNA1G_uc002irt.1_Missense_Mutation_p.S2029F|CACNA1G_uc002irv.1_Missense_Mutation_p.S2036F|CACNA1G_uc002irw.1_Missense_Mutation_p.S2069F|CACNA1G_uc002iru.1_Missense_Mutation_p.S2106F|CACNA1G_uc002irx.1_Missense_Mutation_p.S1960F|CACNA1G_uc002iry.1_Missense_Mutation_p.S1949F|CACNA1G_uc002irz.1_Missense_Mutation_p.S1953F|CACNA1G_uc002isa.1_Missense_Mutation_p.S1926F|CACNA1G_uc002isb.1_Missense_Mutation_p.S1967F|CACNA1G_uc002isc.1_Missense_Mutation_p.S2042F|CACNA1G_uc002isd.1_Missense_Mutation_p.S1935F|CACNA1G_uc002ise.1_Missense_Mutation_p.S1963F|CACNA1G_uc002isf.1_Missense_Mutation_p.S1990F|CACNA1G_uc002isg.1_Missense_Mutation_p.S1908F|CACNA1G_uc002ish.1_Missense_Mutation_p.S1915F|CACNA1G_uc002isi.1_Missense_Mutation_p.S1903F	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	2140	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGGACTGACTCCTTGGACGTTC	0.649											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	31					0	0	6.4e-05	0	0
ABCC3	8714	broad.mit.edu	37	17	48735797	48735797	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:48735797A>G	uc002isl.2	+	6	694	c.614A>G	c.(613-615)AAC>AGC	p.N205S	ABCC3_uc002isk.3_Missense_Mutation_p.N205S	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	205	Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GCCTTCTAGAACCCCTACCCT	0.582													56	47					0	0	0.000781405	0	0
SPAG9	9043	broad.mit.edu	37	17	49052262	49052262	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:49052262G>A	uc002itc.2	-	28	3779	c.3570C>T	c.(3568-3570)ATC>ATT	p.I1190I	SPAG9_uc002itb.2_Silent_p.I1176I|SPAG9_uc002itd.2_Silent_p.I1180I|SPAG9_uc002ita.2_Silent_p.I1046I	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	1190					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			CATATACACGGATTACACTTC	0.413													29	21					0	0	0.001512	0	0
TRIM25	7706	broad.mit.edu	37	17	54969117	54969117	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:54969117G>A	uc002iut.2	-	9	1897	c.1837C>T	c.(1837-1839)CCG>TCG	p.P613S	TRIM25_uc010dcj.2_Missense_Mutation_p.P405S	NM_005082	NP_005073	Q14258	TRI25_HUMAN	tripartite motif-containing 25	613	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding			lung(1)|breast(1)|skin(1)	3	Breast(9;6.15e-08)					CAGAAAGCCGGGTACAAAGCC	0.537													6	20					0	0	0.00116845	0	0
OR4D2	124538	broad.mit.edu	37	17	56247838	56247838	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:56247838C>T	uc010wnp.1	+	1	822	c.822C>T	c.(820-822)GGC>GGT	p.G274G		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TGTCCATCGGCCACACAGTCA	0.532													73	50					0	0	0.000781405	0	0
EPX	8288	broad.mit.edu	37	17	56272453	56272453	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:56272453C>T	uc002ivq.2	+	6	809	c.723C>T	c.(721-723)TCC>TCT	p.S241S		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	241					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						CCCCGGAGTCCCCGGCCAGAG	0.617													23	45					0	0	0.000720815	0	0
LPO	4025	broad.mit.edu	37	17	56344862	56344862	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:56344862G>A	uc002ivt.2	+	12	2162	c.1846G>A	c.(1846-1848)GAG>AAG	p.E616K	LPO_uc010wns.1_Missense_Mutation_p.E557K|LPO_uc010dcp.2_Missense_Mutation_p.E533K|LPO_uc010dcq.2_Missense_Mutation_p.E287K|LPO_uc010dcr.2_Missense_Mutation_p.E179K	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	616					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						GGCCATTGCTGAGCCGCTGGT	0.587													35	23					0	0	0.00128727	0	0
MPO	4353	broad.mit.edu	37	17	56355300	56355300	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:56355300G>A	uc002ivu.1	-	7	1269	c.1092C>T	c.(1090-1092)GCC>GCT	p.A364A		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	364					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	GCTGGTTGACGGCCAGCAGCC	0.652													14	35					0	0	0.00185496	0	0
BZRAP1	9256	broad.mit.edu	37	17	56405038	56405038	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:56405038C>T	uc002ivx.3	-	1	1115	c.244G>A	c.(244-246)GCT>ACT	p.A82T	BZRAP1_uc010dcs.2_Missense_Mutation_p.A82T|BZRAP1_uc010wnt.1_Missense_Mutation_p.A82T|uc010dct.1_5'Flank|uc010dcu.1_5'Flank	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	82						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCAGACAAGCCTCTGCTCCT	0.607													32	24					0	0	0.001512	0	0
C17orf47	284083	broad.mit.edu	37	17	56620146	56620146	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:56620146G>A	uc002iwq.1	-	1	1538	c.1402C>T	c.(1402-1404)CCT>TCT	p.P468S	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	468										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCACAGAAAGGGCTAGAGTCT	0.478													74	178					0	0	0.000781405	0	0
PPM1D	8493	broad.mit.edu	37	17	58678186	58678186	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:58678186G>A	uc002iyt.1	+	1	633	c.411G>A	c.(409-411)AAG>AAA	p.K137K	PPM1D_uc010ddm.1_RNA	NM_003620	NP_003611	O15297	PPM1D_HUMAN	protein phosphatase 1D	137	PP2C-like.				negative regulation of cell proliferation|protein dephosphorylation|response to radiation	nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein binding|protein serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;6.75e-12)|all cancers(12;1.96e-10)			AGCCGGCTAAGGTTTGCGCTG	0.602													57	36					0	0	0.000781405	0	0
TBX2	6909	broad.mit.edu	37	17	59481989	59481989	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:59481989C>T	uc010wox.1	+	5	1191	c.910C>T	c.(910-912)CTA>TTA	p.L304L	TBX2_uc002ize.2_Silent_p.L294L|TBX2_uc002izg.2_Silent_p.L150L	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	304					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						GCTGCCGTCTCTACGCTTGTA	0.697													5	8					0	0	0.00198382	0	0
TBX2	6909	broad.mit.edu	37	17	59485548	59485548	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:59485548C>T	uc010wox.1	+	7	2101	c.1820C>T	c.(1819-1821)TCC>TTC	p.S607F	TBX2_uc002ize.2_3'UTR|TBX2_uc002izg.2_Missense_Mutation_p.S453F	NM_005994	NP_005985	Q13207	TBX2_HUMAN	T-box 2	607					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding				0						gGCTCCCTCTCCCGGAGCCCC	0.438													8	18					0	0	0.000442599	0	0
ACE	1636	broad.mit.edu	37	17	61557834	61557834	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:61557834C>T	uc002jau.1	+	5	814	c.792C>T	c.(790-792)CGC>CGT	p.R264R	ACE_uc010wpi.1_Silent_p.R264R|ACE_uc010ddu.1_Silent_p.R81R	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	264	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CACTGCATCGCCGATACGGAG	0.597													47	39					0	0	0.000781405	0	0
ACE	1636	broad.mit.edu	37	17	61566478	61566478	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:61566478C>T	uc002jau.1	+	17	2648	c.2626C>T	c.(2626-2628)CCT>TCT	p.P876S	ACE_uc002jav.1_Missense_Mutation_p.P302S|ACE_uc010ddv.1_Missense_Mutation_p.P103S|ACE_uc010wpj.1_Missense_Mutation_p.P302S|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Intron	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	876	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGGGCCCATTCCTGCTCACCT	0.632													26	4					0	0	0.00047179	0	0
TACO1	51204	broad.mit.edu	37	17	61685212	61685212	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:61685212C>T	uc002jbd.2	+	5	944	c.744C>T	c.(742-744)TCC>TCT	p.S248S		NM_016360	NP_057444	Q9BSH4	TACO1_HUMAN	translational activator of mitochondrially	248					regulation of translation	mitochondrion					0						AGCTGGACTCCCTGGGCCTGT	0.532													78	5					0	0	0.000781405	0	0
DDX42	11325	broad.mit.edu	37	17	61886219	61886219	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:61886219C>G	uc002jbu.2	+	11	1320	c.1063C>G	c.(1063-1065)CTT>GTT	p.L355V	DDX42_uc002jbv.2_Missense_Mutation_p.L355V|DDX42_uc002jbw.1_Missense_Mutation_p.L91V|DDX42_uc002jbx.2_Missense_Mutation_p.L91V|DDX42_uc002jby.2_5'Flank	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	355	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						AGCATATAATCTTCGATCAGT	0.453													39	58					0	0	0.00195071	0	0
SCN4A	6329	broad.mit.edu	37	17	62018802	62018802	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:62018802C>T	uc002jds.1	-	24	4917	c.4840G>A	c.(4840-4842)GAA>AAA	p.E1614K		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1614					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	AAGTCATCTTCACCAAGGGGC	0.532													29	21					0	0	0.00106085	0	0
LOC146880	146880	broad.mit.edu	37	17	62750165	62750165	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:62750165C>T	uc010wqc.1	-	10		c.2193G>A				NR_026899				Homo sapiens cDNA FLJ30780 fis, clone FEBRA2000856.												0						CCAGAATAATCTTGGTATCTT	0.388													245	35					0	0	0.000781405	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62788625	62788625	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:62788625G>A	uc002jew.3	-	8	2015	c.1104C>T	c.(1102-1104)ATC>ATT	p.I368I	PLEKHM1P_uc002jev.3_RNA	NR_024386				RecName: Full=Putative pleckstrin homology domain-containing family M member 1P;												0						GCTGGGCCCGGATCTGCGTCA	0.607													47	37					0	0	0.000781405	0	0
ABCA6	23460	broad.mit.edu	37	17	67084318	67084318	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:67084318G>A	uc002jhw.1	-	28	3863	c.3688C>T	c.(3688-3690)CCT>TCT	p.P1230S		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1230					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					CTGAAAACAGGATCTTTTCGC	0.323													18	18					0	0	0.00152264	0	0
SLC39A11	201266	broad.mit.edu	37	17	70845886	70845886	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:70845886G>A	uc002jjb.2	-	6	624	c.509C>T	c.(508-510)CCA>CTA	p.P170L	SLC39A11_uc002jja.2_Missense_Mutation_p.P163L|SLC39A11_uc002jjc.1_Missense_Mutation_p.P163L	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	170					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1						AGGACCCTCTGGAAGGCCAGT	0.542													16	63					0	0	0.00152264	0	0
SDK2	54549	broad.mit.edu	37	17	71334736	71334736	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:71334736G>A	uc010dfm.2	-	45	6509	c.6509C>T	c.(6508-6510)TCA>TTA	p.S2170L	SDK2_uc002jjt.3_Missense_Mutation_p.S1310L	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	2170	Cytoplasmic (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TCAAACAAATGATGAAAATCC	0.552													7	16					0	0	0.000157383	0	0
CD300E	342510	broad.mit.edu	37	17	72608905	72608905	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:72608905G>A	uc002jlb.1	-	4	546	c.505C>T	c.(505-507)CTC>TTC	p.L169F		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	169	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GGGCTGCTGAGCCGGAACCTG	0.622													22	51					0	0	0.000586117	0	0
TMEM104	54868	broad.mit.edu	37	17	72791704	72791704	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:72791704C>T	uc002jls.3	+	8	731	c.569C>T	c.(568-570)ACC>ATC	p.T190I	TMEM104_uc010wrf.1_Missense_Mutation_p.T190I|TMEM104_uc010wrg.1_Missense_Mutation_p.T203I|TMEM104_uc010dfx.2_Missense_Mutation_p.T190I	NM_017728	NP_060198	Q8NE00	TM104_HUMAN	transmembrane protein 104	190	Extracellular (Potential).					integral to membrane					0	all_lung(278;0.23)					GAAGCAGACACCAAATACAAT	0.637													7	28					0	0	0.000274275	0	0
C17orf28	283987	broad.mit.edu	37	17	72949729	72949729	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:72949729C>T	uc002jmj.3	-	15	2031	c.1882G>A	c.(1882-1884)GAG>AAG	p.E628K	C17orf28_uc002jmi.2_Missense_Mutation_p.E30K|C17orf28_uc010wrs.1_Missense_Mutation_p.E427K	NM_030630	NP_085133	Q8IV36	CQ028_HUMAN	hypothetical protein LOC283987	628						integral to membrane|plasma membrane	protein binding				0	all_lung(278;0.151)|Lung NSC(278;0.185)					TGGGACTTCTCGGTCAGCTTG	0.597													12	36					0	0	0.000308642	0	0
LLGL2	3993	broad.mit.edu	37	17	73569259	73569259	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:73569259G>A	uc002joh.2	+	20	2779	c.2625G>A	c.(2623-2625)GTG>GTA	p.V875V	LLGL2_uc002joi.2_Silent_p.V875V|LLGL2_uc010dgg.1_Silent_p.V875V|LLGL2_uc002joj.2_Silent_p.V864V|LLGL2_uc010wsd.1_Silent_p.V502V	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	875	WD 13.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			ACATCCAGGTGGTCTCGCTGC	0.657													54	6					0	0	0.000781405	0	0
MGAT5B	146664	broad.mit.edu	37	17	74922790	74922790	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:74922790C>T	uc002jti.2	+	9	1405	c.1302C>T	c.(1300-1302)CCC>CCT	p.P434P	MGAT5B_uc002jth.2_Silent_p.P423P	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	423	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						ACCTCAACCCCAAGCAGTTCA	0.627													66	49					0	0	0.000781405	0	0
DNAH17	8632	broad.mit.edu	37	17	76455266	76455266	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:76455266G>A	uc010dhp.1	-	6	900	c.678C>T	c.(676-678)TTC>TTT	p.F226F	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACTCGGGGTCGAACGTCGGGT	0.458													161	103					0	0	0.000781405	0	0
ENGASE	64772	broad.mit.edu	37	17	77079621	77079621	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:77079621C>T	uc002jwv.2	+	9	1208	c.1200C>T	c.(1198-1200)TTC>TTT	p.F400F	ENGASE_uc002jww.2_Silent_p.F106F	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	400						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						CCTTGCCTTTCGTCACGTCCT	0.627													26	24					0	0	0.00283554	0	0
NARF	26502	broad.mit.edu	37	17	80442816	80442816	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:80442816C>G	uc002kfg.3	+	9	1101	c.961C>G	c.(961-963)CGA>GGA	p.R321G	NARF_uc002kff.3_Missense_Mutation_p.R262G|NARF_uc010wvp.1_3'UTR|NARF_uc010dit.2_Missense_Mutation_p.R367G|NARF_uc002kfj.3_Missense_Mutation_p.R273G|NARF_uc002kfi.3_RNA|NARF_uc002kfh.3_Missense_Mutation_p.R367G|NARF_uc002kfk.2_RNA	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a	321						lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			GGTCACTTACCGAGCCCTGAG	0.577													3	87					0	0	0.00024832	0	0
EMILIN2	84034	broad.mit.edu	37	18	2892007	2892007	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:2892007G>A	uc002kln.2	+	4	2041	c.1882G>A	c.(1882-1884)GAA>AAA	p.E628K		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	628	Potential.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		TCTTCAAAAGGAAATGAGCAA	0.438													21	7					0	0	0.00106085	0	0
LAMA1	284217	broad.mit.edu	37	18	6956713	6956713	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:6956713G>A	uc002knm.2	-	56	8110	c.8016C>T	c.(8014-8016)ACC>ACT	p.T2672T	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Silent_p.T125T|LAMA1_uc010wzj.1_Silent_p.T2148T	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2672	Laminin G-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACAGCCAGCAGGTGTCCAGGT	0.502													52	9					0	0	0.000781405	0	0
CTAGE1	64693	broad.mit.edu	37	18	19995914	19995914	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:19995914C>T	uc002ktv.1	-	1	1965	c.1861G>A	c.(1861-1863)GAT>AAT	p.D621N		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	621						integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					ATTGACCCATCCATTTTATCC	0.393													68	75					0	0	0.000781405	0	0
ZNF521	25925	broad.mit.edu	37	18	22804973	22804973	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:22804973G>A	uc002kvk.2	-	4	3156	c.2909C>T	c.(2908-2910)TCC>TTC	p.S970F	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S970F|ZNF521_uc002kvl.2_Missense_Mutation_p.S750F	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	970	C2H2-type 23.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGTTAAAAGGGAGGGAAACCG	0.488			T	PAX5	ALL								35	29					0	0	0.00170553	0	0
CHST9	83539	broad.mit.edu	37	18	24496436	24496436	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:24496436C>T	uc002kwd.2	-	5	1317	c.1119G>A	c.(1117-1119)TTG>TTA	p.L373L	C18orf16_uc002kwb.2_Intron|C18orf16_uc010xbm.1_Intron|CHST9_uc002kwc.2_Silent_p.L288L|CHST9_uc002kwe.2_Silent_p.L373L	NM_031422	NP_113610	Q7L1S5	CHST9_HUMAN	GalNAc-4-sulfotransferase 2	373	Lumenal (Potential).				carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			ovary(2)|skin(1)	3	all_lung(6;0.0145)|Ovarian(20;0.124)					CATCTTCTTCCAAAGTCTCAA	0.423													41	63					0	0	0.00195071	0	0
DSC1	1823	broad.mit.edu	37	18	28725576	28725576	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:28725576C>T	uc002kwn.2	-	7	1199	c.937G>A	c.(937-939)GAA>AAA	p.E313K	DSC1_uc002kwm.2_Missense_Mutation_p.E313K	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	313	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ATCATTACTTCTCTATCCAGA	0.383													23	34					0	0	0.00278032	0	0
DSG4	147409	broad.mit.edu	37	18	28972276	28972276	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:28972276C>T	uc002kwq.2	+	8	1113	c.978C>T	c.(976-978)ACC>ACT	p.T326T	DSG4_uc002kwr.2_Silent_p.T326T	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	326	Cadherin 3.|Extracellular (Potential).		Missing (in LAH1).		homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ATCCACAAACCAATGAAGGCA	0.333													17	27					0	0	0.00152264	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093053	30093053	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:30093053C>T	uc010dmc.2	+	1		c.1428C>T				NR_003558				Homo sapiens cDNA clone IMAGE:5265376, partial cds.												0						TGAACCTTCCCCCTGGACCAC	0.577													8	5					0	0	0.000157383	0	0
ASXL3	80816	broad.mit.edu	37	18	31311980	31311980	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:31311980G>A	uc010dmg.1	+	9	983	c.928G>A	c.(928-930)GAA>AAA	p.E310K	ASXL3_uc002kxq.2_Missense_Mutation_p.E17K	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TCTAAATAATGAATTCTTTGC	0.378													54	43					0	0	0.000781405	0	0
NOL4	8715	broad.mit.edu	37	18	31802988	31802988	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:31802988G>A	uc010dmi.2	-	1	459	c.230C>T	c.(229-231)GCC>GTC	p.A77V	NOL4_uc002kxr.3_5'Flank|NOL4_uc010xbt.1_5'Flank|NOL4_uc010dmh.2_5'Flank|NOL4_uc010xbu.1_Missense_Mutation_p.A77V|NOL4_uc002kxt.3_Missense_Mutation_p.A77V	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	77						nucleolus	RNA binding			ovary(3)	3						CACTTGCTTGGCGCCGCCGCC	0.622													15	30					0	0	0.000422831	0	0
KIAA1632	57724	broad.mit.edu	37	18	43445620	43445620	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:43445620C>T	uc002lbm.2	-	39	6826	c.6726G>A	c.(6724-6726)ATG>ATA	p.M2242I	KIAA1632_uc010xcq.1_Missense_Mutation_p.M796I|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.M1117I	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	2242					autophagy						0						AGAGCTTAGACATTTCCTGTT	0.438													41	48					0	0	0.00148497	0	0
KIAA1632	57724	broad.mit.edu	37	18	43535255	43535255	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:43535255G>A	uc002lbm.2	-	2	213	c.113C>T	c.(112-114)TCC>TTC	p.S38F	KIAA1632_uc002lbo.1_Missense_Mutation_p.S38F	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	38					autophagy						0						TTTTGGAAGGGAGACTTCACT	0.398													42	29					0	0	0.000680045	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555149	44555149	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:44555149C>T	uc010xdb.1	-	1	1301	c.1065G>A	c.(1063-1065)GTG>GTA	p.V355V	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	355	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						GGACCCCTTCCACGTCGCCGA	0.647													41	467					0	0	0.000781405	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566726	45566726	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:45566726G>A	uc002lda.2	-	1	769	c.753C>T	c.(751-753)TTC>TTT	p.F251F	ZBTB7C_uc002ldb.2_Silent_p.F251F|ZBTB7C_uc010dnu.2_Silent_p.F260F|ZBTB7C_uc010dnv.2_Silent_p.F273F|ZBTB7C_uc010dnw.2_Silent_p.F251F|ZBTB7C_uc010dnx.1_Silent_p.F251F|ZBTB7C_uc010dny.1_Silent_p.F251F|ZBTB7C_uc010dnz.1_Silent_p.F273F|ZBTB7C_uc010dob.1_Silent_p.F251F|ZBTB7C_uc010doc.1_Silent_p.F260F|ZBTB7C_uc010dod.1_Silent_p.F273F|ZBTB7C_uc010doe.1_Silent_p.F251F|ZBTB7C_uc010dof.1_Silent_p.F251F|ZBTB7C_uc010dog.1_Silent_p.F251F|ZBTB7C_uc010doh.1_Silent_p.F260F|ZBTB7C_uc010doi.1_Silent_p.F251F|ZBTB7C_uc010doj.1_Silent_p.F260F|ZBTB7C_uc010dok.1_Silent_p.F300F|ZBTB7C_uc010dol.1_Silent_p.F260F|ZBTB7C_uc010doa.1_Silent_p.F273F|ZBTB7C_uc010don.1_Silent_p.F259F|ZBTB7C_uc010doo.1_Silent_p.F251F|ZBTB7C_uc010dop.1_Silent_p.F251F|ZBTB7C_uc010doq.1_Silent_p.F260F|ZBTB7C_uc010dor.1_Silent_p.F273F|ZBTB7C_uc010dos.1_Silent_p.F251F|ZBTB7C_uc010dot.1_Silent_p.F251F|ZBTB7C_uc010dou.1_Silent_p.F260F|ZBTB7C_uc010dom.1_Silent_p.F260F	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	251						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						AGTCCGGGGCGAATGGAGACA	0.597													22	30					0	0	0.00047179	0	0
MYO5B	4645	broad.mit.edu	37	18	47463690	47463690	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:47463690C>T	uc002leb.2	-	15	2118	c.1830G>A	c.(1828-1830)TCG>TCA	p.S610S	MYO5B_uc002lec.1_Silent_p.S609S	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	610	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CGCTGATCTTCGAAGATGACC	0.532													33	62					0	0	0.000692331	0	0
CCDC11	220136	broad.mit.edu	37	18	47777253	47777253	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:47777253C>T	uc002lee.2	-	5	962	c.871G>A	c.(871-873)GCC>ACC	p.A291T		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	291	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TCTTGTAGGGCTTTTTGCAAA	0.418													120	141					0	0	0.000781405	0	0
MRO	83876	broad.mit.edu	37	18	48333088	48333088	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:48333088C>T	uc002lew.3	-	4	526	c.232G>A	c.(232-234)GAA>AAA	p.E78K	MRO_uc010xdn.1_Missense_Mutation_p.E78K|MRO_uc010dpa.2_Missense_Mutation_p.E92K|MRO_uc010dpb.2_Missense_Mutation_p.E92K|MRO_uc010dpc.2_Missense_Mutation_p.E78K|MRO_uc002lex.3_Missense_Mutation_p.E78K	NM_031939	NP_114145	Q9BYG7	MSTRO_HUMAN	maestro isoform a	78						nucleolus	binding				0		Colorectal(6;0.0596)		Colorectal(21;0.082)		TCAGGGGCTTCATAGGCCATG	0.547													61	60					0	0	0.000781405	0	0
DCC	1630	broad.mit.edu	37	18	50278697	50278697	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:50278697G>A	uc002lfe.1	+	2	952	c.365G>A	c.(364-366)GGA>GAA	p.G122E	DCC_uc010xdr.1_5'UTR	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	122	Extracellular (Potential).|Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCATCTTTAGGAGATTCTGGC	0.343													56	62					0	0	0.000781405	0	0
DCC	1630	broad.mit.edu	37	18	50705414	50705414	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:50705414C>T	uc002lfe.1	+	9	2088	c.1501C>T	c.(1501-1503)CGA>TGA	p.R501*	DCC_uc010xdr.1_Nonsense_Mutation_p.R349*|DCC_uc010dpf.1_Nonsense_Mutation_p.R156*	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	501	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTACACCTTTCGAGTTGTGGC	0.507													16	22					0	0	0.000958276	0	0
DCC	1630	broad.mit.edu	37	18	51013171	51013171	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:51013171C>T	uc002lfe.1	+	26	4328	c.3741C>T	c.(3739-3741)GTC>GTT	p.V1247V	DCC_uc010dpf.1_Silent_p.V882V	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1247	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TTGCAGCTGTCGTGAGCGCCA	0.483													31	57					0	0	0.00058488	0	0
POLI	11201	broad.mit.edu	37	18	51820381	51820381	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:51820381C>T	uc002lfj.3	+	10	1835	c.1767C>T	c.(1765-1767)TCC>TCT	p.S589S	POLI_uc010xds.1_Silent_p.S510S|POLI_uc002lfk.3_Silent_p.S486S|POLI_uc010dpg.2_Silent_p.S185S	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	589	Ser-rich.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		ATCATTTATCCAGTAGCAAAC	0.368								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					23	43					0	0	0.00278032	0	0
RAB27B	5874	broad.mit.edu	37	18	52556589	52556589	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:52556589G>A	uc002lfr.2	+	6	713	c.602G>A	c.(601-603)GGA>GAA	p.G201E		NM_004163	NP_004154	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	201					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity				0				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		GTCAATGGTGGAAATTCTGGA	0.413													23	28					0	0	0.00229938	0	0
TCF4	6925	broad.mit.edu	37	18	52927248	52927248	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:52927248G>A	uc002lfz.2	-	13	1613	c.1001C>T	c.(1000-1002)CCA>CTA	p.P334L	TCF4_uc002lfw.3_Missense_Mutation_p.P174L|TCF4_uc010xdu.1_Missense_Mutation_p.P204L|TCF4_uc010xdv.1_Missense_Mutation_p.P204L|TCF4_uc002lfx.2_Missense_Mutation_p.P263L|TCF4_uc010xdw.1_Missense_Mutation_p.P204L|TCF4_uc002lfy.2_Missense_Mutation_p.P292L|TCF4_uc010xdx.1_Missense_Mutation_p.P310L|TCF4_uc010dph.1_Missense_Mutation_p.P334L|TCF4_uc010xdy.1_Missense_Mutation_p.P310L|TCF4_uc002lga.2_Missense_Mutation_p.P436L|TCF4_uc002lgb.1_Missense_Mutation_p.P174L|TCF4_uc010dpi.2_Missense_Mutation_p.P340L|TCF4_uc002lfv.2_Missense_Mutation_p.P118L	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	334				P -> S (in Ref. 7; CAA36298).	positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		AGTGTGATCTGGAGAATAGAT	0.343													48	70					0	0	0.000781405	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55027470	55027470	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:55027470G>A	uc002lgn.2	+	4	1462	c.1105G>A	c.(1105-1107)GAA>AAA	p.E369K		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	369	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		AATGCATGGGGAAGGGCTCAC	0.473													12	24					0	0	0.00244969	0	0
ATP8B1	5205	broad.mit.edu	37	18	55368546	55368546	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:55368546C>T	uc002lgw.2	-	4	394	c.394_splice	c.e4-1	p.A132_splice	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1						ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				GAGGAACTGCCTAAAAGAATA	0.463									Byler_disease				32	31					0	0	0.00058488	0	0
NEDD4L	23327	broad.mit.edu	37	18	56008369	56008369	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:56008369C>T	uc002lgy.2	+	14	1499	c.1225C>T	c.(1225-1227)CGA>TGA	p.R409*	NEDD4L_uc002lgz.2_Intron|NEDD4L_uc002lgx.2_Nonsense_Mutation_p.R389*|NEDD4L_uc010xee.1_Nonsense_Mutation_p.R288*|NEDD4L_uc002lhc.2_Nonsense_Mutation_p.R401*|NEDD4L_uc002lhd.2_Nonsense_Mutation_p.R288*|NEDD4L_uc002lhb.2_Nonsense_Mutation_p.R268*|NEDD4L_uc002lhe.2_Nonsense_Mutation_p.R381*|NEDD4L_uc002lhf.2_Nonsense_Mutation_p.R268*|NEDD4L_uc002lhg.2_Nonsense_Mutation_p.R288*|NEDD4L_uc002lhh.2_Intron|NEDD4L_uc010dpm.1_Intron	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	409	WW 2.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						TCATAACAATCGAACCACAAC	0.488													14	8					0	0	0.000308642	0	0
ALPK2	115701	broad.mit.edu	37	18	56203768	56203768	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:56203768G>A	uc002lhj.3	-	5	3865	c.3651C>T	c.(3649-3651)ATC>ATT	p.I1217I	ALPK2_uc002lhk.1_Silent_p.I548I	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1217				I -> T (in Ref. 4; BAC03812).			ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CTTCCAAAAGGATATCAGAGA	0.512													90	98					0	0	0.000781405	0	0
ALPK2	115701	broad.mit.edu	37	18	56204337	56204337	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:56204337G>A	uc002lhj.3	-	5	3296	c.3082C>T	c.(3082-3084)CCT>TCT	p.P1028S	ALPK2_uc002lhk.1_Missense_Mutation_p.P359S	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1028							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TTGTCCTCAGGAATTGACACA	0.483													41	59					0	0	0.00222228	0	0
CDH20	28316	broad.mit.edu	37	18	59166487	59166487	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:59166487C>G	uc010dps.1	+	2	327	c.315C>G	c.(313-315)ATC>ATG	p.I105M	CDH20_uc002lif.2_Missense_Mutation_p.I99M	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	105	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				GTGCTGGCATCGTGTTTACCA	0.517													13	29					0	0	0.000422831	0	0
CDH20	28316	broad.mit.edu	37	18	59206374	59206374	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:59206374G>A	uc010dps.1	+	8	1538	c.1526G>A	c.(1525-1527)GGA>GAA	p.G509E	CDH20_uc002lif.2_Missense_Mutation_p.G503E	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	509	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				GCCAAGGCAGGACAGGTAAGG	0.453													90	79					0	0	0.000781405	0	0
CDH7	1005	broad.mit.edu	37	18	63547753	63547753	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:63547753G>A	uc002ljz.2	+	12	2306	c.1981G>A	c.(1981-1983)GAG>AAG	p.E661K	CDH7_uc002lkb.2_Missense_Mutation_p.E661K	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	661	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CGGGGGAGAGGAGGACACGGA	0.488													28	58					0	0	0.00127121	0	0
CD226	10666	broad.mit.edu	37	18	67614097	67614097	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:67614097C>T	uc010dqo.2	-	2	702	c.255G>A	c.(253-255)ACG>ACA	p.T85T	CD226_uc002lkm.3_Silent_p.T85T	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	85	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				TGGAAGCCATCGTTGAATTCA	0.458													29	27					0	0	0.001512	0	0
RTTN	25914	broad.mit.edu	37	18	67833372	67833372	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:67833372G>A	uc002lkp.2	-	14	1923	c.1855C>T	c.(1855-1857)CTT>TTT	p.L619F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	619							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				ATATGGAGAAGCACCTTCTGA	0.433													26	14					0	0	0.000878237	0	0
CBLN2	147381	broad.mit.edu	37	18	70205419	70205419	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:70205419G>A	uc002lku.2	-	4	902	c.667C>T	c.(667-669)CCT>TCT	p.P223S	CBLN2_uc002lkv.2_Missense_Mutation_p.P223S	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	223	C1q.					integral to membrane					0		Esophageal squamous(42;0.131)				GTTTATAGAGGAAACACCAAG	0.507													16	27					0	0	0.000566183	0	0
SALL3	27164	broad.mit.edu	37	18	76753212	76753212	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:76753212C>T	uc002lmt.2	+	2	1221	c.1221C>T	c.(1219-1221)TTC>TTT	p.F407F	SALL3_uc010dra.2_Silent_p.F14F	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	407					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TGTCGGTGTTCGAGCCCAAAG	0.657													11	18					0	0	0.000673444	0	0
NFATC1	4772	broad.mit.edu	37	18	77170711	77170711	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:77170711C>T	uc010xfg.1	+	2	889	c.436C>T	c.(436-438)CCT>TCT	p.P146S	NFATC1_uc002lnc.1_Missense_Mutation_p.P146S|NFATC1_uc010xff.1_Missense_Mutation_p.P146S|NFATC1_uc002lnd.2_Missense_Mutation_p.P146S|NFATC1_uc002lne.2_Intron|NFATC1_uc010xfh.1_Missense_Mutation_p.P146S|NFATC1_uc010xfi.1_Missense_Mutation_p.P133S|NFATC1_uc010xfj.1_Intron|NFATC1_uc002lnf.2_Missense_Mutation_p.P133S|NFATC1_uc002lng.2_Missense_Mutation_p.P133S|NFATC1_uc010xfk.1_Missense_Mutation_p.P133S	NM_006162	NP_006153	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytosolic	146	Trans-activation domain A (TAD-A).				intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		AGACGTCCTCCCTAGCTCCAA	0.622													23	18					0	0	0.000586117	0	0
CTDP1	9150	broad.mit.edu	37	18	77477664	77477664	+	Missense_Mutation	SNP	C	T	T	rs138106090		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:77477664C>T	uc002lnh.1	+	9	2345	c.2198C>T	c.(2197-2199)ACC>ATC	p.T733I	CTDP1_uc002lni.1_Missense_Mutation_p.T733I|CTDP1_uc010drd.1_Missense_Mutation_p.T733I	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	733					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		GACGATCACACCAAGGCACAG	0.642													26	49					0	0	0.00178596	0	0
AZU1	566	broad.mit.edu	37	19	831860	831860	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:831860G>A	uc002lpz.1	+	5	755	c.739G>A	c.(739-741)GGA>AGA	p.G247R		NM_001700	NP_001691	P20160	CAP7_HUMAN	azurocidin 1 preproprotein	247					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAACAACCCGGGACCGGGGCC	0.468													42	34					0	0	0.000781405	0	0
ARID3A	1820	broad.mit.edu	37	19	929675	929675	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:929675C>T	uc002lql.2	+	2	437	c.147C>T	c.(145-147)CCC>CCT	p.P49P		NM_005224	NP_005215	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT- like)	49						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACAGAGAGCCCGAGAGTGCCC	0.642													5	3					0	0	0.00116845	0	0
GRIN3B	116444	broad.mit.edu	37	19	1005144	1005144	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:1005144C>T	uc002lqo.1	+	3	1644	c.1644C>T	c.(1642-1644)TTC>TTT	p.F548F		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	548	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCAGCCCCTTCTTCTCCACCA	0.672													17	38					0	0	0.000958276	0	0
C19orf36	113177	broad.mit.edu	37	19	2099315	2099315	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:2099315G>A	uc002luw.1	+	10	747	c.670G>A	c.(670-672)GAT>AAT	p.D224N	C19orf36_uc002lux.1_Missense_Mutation_p.D206N|C19orf36_uc010xgw.1_3'UTR	NM_001039846	NP_001034935	Q1ZYL8	IZUM4_HUMAN	hypothetical protein LOC113177 isoform 3	224						extracellular region					0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACCTTGGAAGATGCTGCTGA	0.642													5	25					0	0	0.00116845	0	0
TLE2	7089	broad.mit.edu	37	19	3002402	3002402	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:3002402G>A	uc002lww.2	-	18	2259	c.1996C>T	c.(1996-1998)CAG>TAG	p.Q666*	TLE2_uc010xhb.1_Nonsense_Mutation_p.Q333*|TLE2_uc010dth.2_Nonsense_Mutation_p.Q667*|TLE2_uc010xhc.1_Nonsense_Mutation_p.Q544*|TLE2_uc010dti.2_Nonsense_Mutation_p.Q680*	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	666					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGCAGCTGGTATTTCTCC	0.607													18	6					0	0	0.00121646	0	0
TLE2	7089	broad.mit.edu	37	19	3009539	3009539	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:3009539C>T	uc002lww.2	-	13	1436	c.1173_splice	c.e13+1	p.V391_splice	TLE2_uc010xhb.1_Splice_Site_p.V58_splice|TLE2_uc010dth.2_Splice_Site_p.V392_splice|TLE2_uc010xhc.1_Splice_Site_p.V269_splice|TLE2_uc010dti.2_Splice_Site_p.V405_splice|TLE2_uc010xhd.1_Splice_Site_p.V299_splice	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1						negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAAGGACTCACCACGGGGGAG	0.632													5	17					0	0	0.00198382	0	0
AES	166	broad.mit.edu	37	19	3054025	3054025	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:3054025G>A	uc002lwy.1	-	7	559	c.386C>T	c.(385-387)GCC>GTC	p.A129V	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Missense_Mutation_p.A128V|AES_uc002lxa.1_Missense_Mutation_p.A73V|AES_uc002lxb.1_Missense_Mutation_p.A196V|AES_uc002lxc.2_Silent_p.S222S	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	129	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCTGGTGGGCTTGGAGCTG	0.716													7	1					0	0	0.00198382	0	0
PIP5K1C	23396	broad.mit.edu	37	19	3643366	3643366	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:3643366G>A	uc002lyj.1	-	13	1581	c.1524C>T	c.(1522-1524)CTC>CTT	p.L508L	PIP5K1C_uc010xhq.1_Silent_p.L508L|PIP5K1C_uc010xhr.1_Silent_p.L508L	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	508					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		TGCAGGGCAGGAGGTCGGGCC	0.637													41	83					0	0	0.00285205	0	0
TJP3	27134	broad.mit.edu	37	19	3733818	3733819	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:3733818_3733819GG>AA	uc010xhv.1	+	6	842_843	c.842_843GG>AA	c.(841-843)GGG>GAA	p.G281E	TJP3_uc010xhs.1_Missense_Mutation_p.G262E|TJP3_uc010xht.1_Missense_Mutation_p.G226E|TJP3_uc010xhu.1_Missense_Mutation_p.G271E|TJP3_uc010xhw.1_Missense_Mutation_p.G281E	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	262	PDZ 2.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGTCAGAAGGGAAGCTAAGCC	0.564													44	81					0	0	6.4e-05	0	0
ACSBG2	81616	broad.mit.edu	37	19	6147620	6147620	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:6147620G>A	uc002mef.1	+	3	458	c.231G>A	c.(229-231)AAG>AAA	p.K77K	ACSBG2_uc002mee.1_Translation_Start_Site|ACSBG2_uc002meg.1_Silent_p.K77K|ACSBG2_uc002meh.1_Silent_p.K77K|ACSBG2_uc002mei.1_Silent_p.K27K|ACSBG2_uc010xiz.1_Silent_p.K77K	NM_030924	NP_112186	Q5FVE4	ACBG2_HUMAN	bubblegum-related acyl-CoA synthetase 2	77					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			ovary(1)	1						ATGGCAAAAAGTGGGAAATTC	0.398													45	135					0	0	0.000781405	0	0
SLC25A41	284427	broad.mit.edu	37	19	6433579	6433579	+	Nonsense_Mutation	SNP	C	T	T	rs150906124	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:6433579C>T	uc010dus.2	-	1	212	c.126G>A	c.(124-126)TGG>TGA	p.W42*	SLC25A41_uc010dut.2_5'UTR	NM_173637	NP_775908	Q8N5S1	S2541_HUMAN	solute carrier family 25, member 41	42	Pro-rich.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						AGCCAGGGTTCCAggatgggg	0.398													19	38					0	0	0.00074312	0	0
C3	718	broad.mit.edu	37	19	6685135	6685135	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:6685135G>A	uc002mfm.2	-	30	3895	c.3833C>T	c.(3832-3834)GCC>GTC	p.A1278V	C3_uc002mfl.2_Missense_Mutation_p.A14V	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1278					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		TTGAGCCAAGGCTTGGAACAC	0.542													14	11					0	0	0.000422831	0	0
C3	718	broad.mit.edu	37	19	6707815	6707815	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:6707815C>T	uc002mfm.2	-	15	2033	c.1971G>A	c.(1969-1971)AGG>AGA	p.R657R		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	657					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCTCACCTGCCCTCTGGGCGG	0.557													56	37					0	0	0.000781405	0	0
SNAPC2	6618	broad.mit.edu	37	19	7987171	7987171	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:7987171G>A	uc002miw.1	+	4	647	c.624G>A	c.(622-624)AAG>AAA	p.K208K	SNAPC2_uc002mix.1_RNA	NM_003083	NP_003074	Q13487	SNPC2_HUMAN	small nuclear RNA activating complex,	208					snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	sequence-specific DNA binding transcription factor activity				0						ACTTTGAGAAGATCTACAAGT	0.592													27	64					0	0	0.00178596	0	0
FBN3	84467	broad.mit.edu	37	19	8154839	8154839	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:8154839G>A	uc002mjf.2	-	49	6210	c.6189C>T	c.(6187-6189)GCC>GCT	p.A2063A	FBN3_uc002mje.2_5'UTR	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2063	TB 8.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GCTCCTGAAAGGCAGCTGGAC	0.637													6	22					0	0	0.00116845	0	0
PRAM1	84106	broad.mit.edu	37	19	8563512	8563512	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:8563512G>A	uc002mkd.2	-	2	1200	c.1180C>T	c.(1180-1182)CCT>TCT	p.P394S	PRAM1_uc002mkc.2_Missense_Mutation_p.P394S	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	442	Pro-rich.						lipid binding|protein binding				0						ACGGCCGCAGGCAGTGAGCTC	0.672													19	8					0	0	0.00188189	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8645836	8645836	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:8645836G>A	uc002mkj.1	-	26	3527	c.3253C>T	c.(3253-3255)CAG>TAG	p.Q1085*	ADAMTS10_uc002mki.1_Nonsense_Mutation_p.Q572*	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1085	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						CTGCAGAACTGAAATTTGAGC	0.627											OREG0025220	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	12					0	0	0.000602214	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8657694	8657694	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:8657694G>A	uc002mkj.1	-	13	1814	c.1540C>T	c.(1540-1542)CCG>TCG	p.P514S	ADAMTS10_uc002mki.1_5'Flank|ADAMTS10_uc002mkk.1_Missense_Mutation_p.P146S	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	514	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						TCGGCGGCCGGGATGCTGTTG	0.716													31	39					0	0	0.00058488	0	0
MUC16	94025	broad.mit.edu	37	19	9008208	9008208	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9008208G>A	uc002mkp.2	-	41	39548	c.39344C>T	c.(39343-39345)CCC>CTC	p.P13115L	MUC16_uc010dwi.2_5'Flank|MUC16_uc010dwj.2_5'Flank|MUC16_uc010xki.1_Intron	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	13117	Extracellular (Potential).|SEA 7.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGGGTGTAGGGGCCCAGCTC	0.547													75	80					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9015627	9015627	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9015627C>T	uc002mkp.2	-	29	38400	c.38196G>A	c.(38194-38196)CAG>CAA	p.Q12732Q	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12734	SEA 5.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAACCAGACTCTGCAGGACTC	0.527													61	39					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9048013	9048013	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9048013C>T	uc002mkp.2	-	5	33822	c.33618G>A	c.(33616-33618)GGG>GGA	p.G11206G		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11208	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGTCACCAGCCCTTGTACAG	0.478													20	14					0	0	0.00152264	0	0
MUC16	94025	broad.mit.edu	37	19	9056795	9056795	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9056795G>A	uc002mkp.2	-	3	30855	c.30651C>T	c.(30649-30651)GCC>GCT	p.A10217A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10219	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TATACTGTGAGGCTGGAGGCC	0.468													21	44					0	0	0.00188189	0	0
MUC16	94025	broad.mit.edu	37	19	9066457	9066457	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9066457G>A	uc002mkp.2	-	3	21193	c.20989C>T	c.(20989-20991)CCT>TCT	p.P6997S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6999	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGGGCCAGGGATGGATGTT	0.483													118	68					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9068232	9068232	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9068232G>A	uc002mkp.2	-	3	19418	c.19214C>T	c.(19213-19215)TCC>TTC	p.S6405F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6407	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCTGCTAGAGGAGGTGAGTTC	0.498													20	48					0	0	0.00121646	0	0
MUC16	94025	broad.mit.edu	37	19	9069614	9069614	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9069614G>A	uc002mkp.2	-	3	18036	c.17832C>T	c.(17830-17832)TCC>TCT	p.S5944S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5946	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGATACTGCGGAATAAAGAG	0.512													45	20					0	0	0.0025221	0	0
MUC16	94025	broad.mit.edu	37	19	9070567	9070567	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9070567C>T	uc002mkp.2	-	3	17083	c.16879G>A	c.(16879-16881)GAA>AAA	p.E5627K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5629	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGCTGGTTTCTTCCACAGGG	0.532													16	12					0	0	0.000422831	0	0
MUC16	94025	broad.mit.edu	37	19	9072421	9072421	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9072421C>T	uc002mkp.2	-	3	15229	c.15025G>A	c.(15025-15027)GGA>AGA	p.G5009R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5011	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTGAAAATCCATGAGTCATA	0.488													23	68					0	0	0.000586117	0	0
MUC16	94025	broad.mit.edu	37	19	9075413	9075414	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9075413_9075414GG>AA	uc002mkp.2	-	3	12236_12237	c.12032_12033CC>TT	c.(12031-12033)TCC>TTT	p.S4011F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4013	Thr-rich.|Extracellular (Potential).|Ser-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGTCAAGAAGGAATTAGGCTC	0.475													15	53					0	0	6.4e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9075994	9075994	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9075994G>A	uc002mkp.2	-	3	11656	c.11452C>T	c.(11452-11454)CCC>TCC	p.P3818S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3819	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGGTGGTGGGAAGCTGAGTG	0.507													59	155					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9076487	9076487	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9076487C>T	uc002mkp.2	-	3	11163	c.10959G>A	c.(10957-10959)AAG>AAA	p.K3653K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3654	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTCTCTGTCTTTACAGCTG	0.473													17	41					0	0	0.000422831	0	0
MUC16	94025	broad.mit.edu	37	19	9086175	9086175	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9086175A>T	uc002mkp.2	-	1	5844	c.5640T>A	c.(5638-5640)GAT>GAA	p.D1880E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1880	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGAAGAGGTATCAGAGCCGT	0.502													22	12					0	0	0.00278032	0	0
MUC16	94025	broad.mit.edu	37	19	9086177	9086177	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9086177C>T	uc002mkp.2	-	1	5842	c.5638G>A	c.(5638-5640)GAT>AAT	p.D1880N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1880	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAAGAGGTATCAGAGCCGTTT	0.507													22	11					0	0	0.00278032	0	0
MUC16	94025	broad.mit.edu	37	19	9088106	9088106	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9088106G>A	uc002mkp.2	-	1	3913	c.3709C>T	c.(3709-3711)CCA>TCA	p.P1237S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1237	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGAGGGTTGGAAGTCCCCCT	0.507													83	204					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9089251	9089251	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9089251G>A	uc002mkp.2	-	1	2768	c.2564C>T	c.(2563-2565)CCT>CTT	p.P855L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	855	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGAGTGGAAGGAGTAGATGA	0.463													41	27					0	0	0.00170553	0	0
MUC16	94025	broad.mit.edu	37	19	9090497	9090497	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9090497G>A	uc002mkp.2	-	1	1522	c.1318C>T	c.(1318-1320)CTT>TTT	p.L440F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	440	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGGTCTCAAGTGGAGTCATA	0.473													80	49					0	0	0.000781405	0	0
OR1M1	125963	broad.mit.edu	37	19	9204520	9204520	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9204520C>T	uc010xkj.1	+	1	600	c.600C>T	c.(598-600)CTC>CTT	p.L200L		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						TCTTCATCCTCATTGTGGCAG	0.567													50	45					0	0	0.000781405	0	0
OR7G3	390883	broad.mit.edu	37	19	9237262	9237262	+	Missense_Mutation	SNP	C	T	T	rs144765135		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9237262C>T	uc010xkl.1	-	1	365	c.365G>A	c.(364-366)CGA>CAA	p.R122Q		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGCCACAAATCGATCATAGGC	0.473													31	61					0	0	0.00283554	0	0
ZNF317	57693	broad.mit.edu	37	19	9271094	9271094	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9271094C>T	uc002mku.2	+	7	1048	c.773C>T	c.(772-774)GCC>GTC	p.A258V	ZNF317_uc002mkv.2_Missense_Mutation_p.A117V|ZNF317_uc002mkw.2_Missense_Mutation_p.A226V|ZNF317_uc002mkx.2_Missense_Mutation_p.A173V|ZNF317_uc002mky.2_Missense_Mutation_p.A141V	NM_020933	NP_065984	Q96PQ6	ZN317_HUMAN	zinc finger protein 317	258	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCGGGAAAGCCTTCAACGAC	0.572													17	52					0	0	0.000422831	0	0
OR7D2	162998	broad.mit.edu	37	19	9296615	9296615	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9296615C>T	uc002mkz.1	+	1	346	c.158C>T	c.(157-159)TCC>TTC	p.S53F		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	53	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						AGCTCTGACTCCCACCTCCAC	0.537													28	13					0	0	0.00106085	0	0
ZNF562	54811	broad.mit.edu	37	19	9763879	9763879	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:9763879G>A	uc010xks.1	-	6	1190	c.1027C>T	c.(1027-1029)CCC>TCC	p.P343S	ZNF562_uc002mly.2_Missense_Mutation_p.P343S|ZNF562_uc002mlx.2_Missense_Mutation_p.P271S|ZNF562_uc010xkt.1_Missense_Mutation_p.P306S|ZNF562_uc010xku.1_Missense_Mutation_p.P274S|ZNF562_uc010xkv.1_Missense_Mutation_p.P342S|ZNF562_uc010xkw.1_Missense_Mutation_p.P227S	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATTCATAGGGTTTTATTCCA	0.428													36	66					0	0	0.00111076	0	0
RDH8	50700	broad.mit.edu	37	19	10132293	10132293	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:10132293A>G	uc002mmr.2	+	6	1053	c.804A>G	c.(802-804)AAA>AAG	p.K268K		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	268					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	CCACGCTCAAAACCGTGGATT	0.612													23	26					0	0	0.00188189	0	0
TYK2	7297	broad.mit.edu	37	19	10461603	10461603	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:10461603G>A	uc002moc.3	-	25	3849	c.3471C>T	c.(3469-3471)TCC>TCT	p.S1157S	TYK2_uc010dxe.2_Silent_p.S972S	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	1157	Protein kinase 2.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			TTGGGCGAAAGGACGCCTCTG	0.552													40	30					0	0	0.00222228	0	0
TYK2	7297	broad.mit.edu	37	19	10475409	10475409	+	Silent	SNP	G	A	A	rs138350396	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:10475409G>A	uc002moc.3	-	9	1626	c.1248C>T	c.(1246-1248)TTC>TTT	p.F416F	TYK2_uc010dxe.2_Silent_p.F231F|TYK2_uc002mod.2_Silent_p.F416F	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	416	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCAGCGACACGAAGGACAGCG	0.682													20	18					0	0	0.00121646	0	0
ZNF441	126068	broad.mit.edu	37	19	11891506	11891506	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:11891506T>G	uc010dyj.2	+	4	1061	c.867T>G	c.(865-867)TTT>TTG	p.F289L	ZNF441_uc002msn.3_Missense_Mutation_p.F245L	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	289	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGAAAGCATTTTATCATCTTG	0.403													41	27					0	0	0.00222228	0	0
ZNF442	79973	broad.mit.edu	37	19	12461073	12461073	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:12461073G>A	uc002mtr.1	-	6	1937	c.1326C>T	c.(1324-1326)TTC>TTT	p.F442F	ZNF442_uc010xmk.1_Silent_p.F373F	NM_030824	NP_110451	Q9H7R0	ZN442_HUMAN	zinc finger protein 442	442	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|breast(1)|kidney(1)	4						TAGAAATACGGAAGGCTTTAC	0.383													47	37					0	0	0.000781405	0	0
ZNF799	90576	broad.mit.edu	37	19	12502327	12502327	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:12502327G>A	uc010dyt.2	-	4	1035	c.885C>T	c.(883-885)TCC>TCT	p.S295S	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	295	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						GTCTTCGAAGGGAAGTGGAAG	0.433													44	82					0	0	0.0025221	0	0
ZNF709	163051	broad.mit.edu	37	19	12575850	12575850	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:12575850G>A	uc002mtv.3	-	4	1047	c.886C>T	c.(886-888)CGA>TGA	p.R296*	ZNF709_uc002mtw.3_Nonsense_Mutation_p.R264*|ZNF709_uc002mtx.3_Nonsense_Mutation_p.R296*	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	296	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCATGACTTCGAAAGGATGTG	0.363													17	11					0	0	0.000566183	0	0
DNASE2	1777	broad.mit.edu	37	19	12989369	12989369	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:12989369G>A	uc002mvn.1	-	5	682	c.536C>T	c.(535-537)CCC>CTC	p.P179L	DNASE2_uc010xmr.1_Missense_Mutation_p.P124L	NM_001375	NP_001366	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal precursor	179					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding				0						ATAGACCCAGGGGTAGGTGTA	0.547								Direct_reversal_of_damage					17	15					0	0	0.00152264	0	0
RAD23A	5886	broad.mit.edu	37	19	13059062	13059062	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:13059062C>T	uc002mvw.1	+	3	415	c.306C>T	c.(304-306)TCC>TCT	p.S102S	RAD23A_uc002mvx.1_Silent_p.S102S|RAD23A_uc002mvz.1_Silent_p.S102S|RAD23A_uc002mwa.1_Silent_p.S102S|RAD23A_uc002mvy.1_5'UTR|RAD23A_uc010xmw.1_5'UTR	NM_005053	NP_005044	P54725	RD23A_HUMAN	UV excision repair protein RAD23 homolog A	102					interspecies interaction between organisms|nucleotide-excision repair|positive regulation of viral genome replication|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			central_nervous_system(1)	1						CCTCTACATCCTTCCCGCCTG	0.642								NER					8	24					0	0	0.000274275	0	0
CACNA1A	773	broad.mit.edu	37	19	13476261	13476261	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:13476261C>T	uc010dze.2	-	5	890	c.654G>A	c.(652-654)TCG>TCA	p.S218S	CACNA1A_uc002mwy.3_Silent_p.S218S	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	218	Cytoplasmic (Potential).|I.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCTTCATGATCGACTTCAGGA	0.493													16	29					0	0	0.000958276	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13923865	13923865	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:13923865C>T	uc002mxh.1	+	6	1256	c.1067C>T	c.(1066-1068)GCA>GTA	p.A356V	ZSWIM4_uc010xng.1_Missense_Mutation_p.A162V	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	356							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GAGGAAAGGGCAGGCTGGCTC	0.637													23	21					0	0	0.00047179	0	0
SLC1A6	6511	broad.mit.edu	37	19	15067385	15067385	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:15067385G>A	uc002naa.1	-	6	1080	c.1072C>T	c.(1072-1074)CTT>TTT	p.L358F	SLC1A6_uc010dzu.1_Intron|SLC1A6_uc010xod.1_Missense_Mutation_p.L294F	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	358	Helical; (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	ATGAGGGGAAGGACAATGCCG	0.587													7	15					0	0	0.000157383	0	0
CYP4F12	66002	broad.mit.edu	37	19	15784509	15784509	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:15784509G>A	uc002nbl.2	+	2	231	c.170G>A	c.(169-171)CGG>CAG	p.R57Q	CYP4F12_uc010xoo.1_Missense_Mutation_p.R57Q|CYP4F12_uc010xop.1_Missense_Mutation_p.R57Q	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					CCCCCAAAACGGAACTGGTTT	0.587													73	40					0	0	0.000781405	0	0
OR10H5	284433	broad.mit.edu	37	19	15905071	15905071	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:15905071C>T	uc010xos.1	+	1	213	c.213C>T	c.(211-213)ATC>ATT	p.I71I		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCACCGAGATCCTCTACACCG	0.622													19	24					0	0	0.000958276	0	0
OR10H1	26539	broad.mit.edu	37	19	15918208	15918208	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:15918208G>A	uc002nbq.2	-	1	729	c.640C>T	c.(640-642)CTC>TTC	p.L214F		NM_013940	NP_039228	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H,	214	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGAGGATGAGGAGAAAACAG	0.577													17	40					0	0	0.000720815	0	0
RAB8A	4218	broad.mit.edu	37	19	16238862	16238862	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:16238862C>T	uc002ndn.3	+	6	663	c.441C>T	c.(439-441)TTC>TTT	p.F147F	RAB8A_uc010xpc.1_Silent_p.F147F|RAB8A_uc002ndo.3_Missense_Mutation_p.H26Y	NM_005370	NP_005361	P61006	RAB8A_HUMAN	mel transforming oncogene	147					cilium assembly|Golgi vesicle fusion to target membrane|protein transport|small GTPase mediated signal transduction|vesicle docking involved in exocytosis	Golgi apparatus|nonmotile primary cilium|perinuclear region of cytoplasm|plasma membrane	GTP binding|protein binding			skin(1)	1						GAATCAAGTTCATGGAGACCA	0.597													14	37					0	0	0.000308642	0	0
CALR3	125972	broad.mit.edu	37	19	16594862	16594862	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:16594862A>G	uc002ned.2	-	5	620	c.557T>C	c.(556-558)ATT>ACT	p.I186T	MED26_uc002nee.2_Intron	NM_145046	NP_659483	Q96L12	CALR3_HUMAN	calreticulin 3 precursor	186	N-domain.				protein folding	endoplasmic reticulum lumen	calcium ion binding|sugar binding|unfolded protein binding				0						CTGACCATCAATTTTCACATC	0.413													25	16					0	0	0.00106085	0	0
NWD1	284434	broad.mit.edu	37	19	16870130	16870130	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:16870130G>A	uc002neu.3	+	7	2286	c.1864G>A	c.(1864-1866)GAG>AAG	p.E622K	NWD1_uc002net.3_Missense_Mutation_p.E487K|NWD1_uc002nev.3_Missense_Mutation_p.E416K			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	622	NACHT.						ATP binding			skin(3)|ovary(2)|pancreas(2)	7						GCCCAGCAAGGAGCTGCTGCG	0.642													7	25					0	0	0.000157383	0	0
CPAMD8	27151	broad.mit.edu	37	19	17039796	17039796	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:17039796C>T	uc002nfb.2	-	24	3273	c.3241G>A	c.(3241-3243)GAA>AAA	p.E1081K		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1034						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GTTCTGAATTCATCCCAGGAG	0.562													17	39					0	0	0.00121646	0	0
MYO9B	4650	broad.mit.edu	37	19	17212990	17212990	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:17212990C>T	uc010eak.2	+	2	615	c.463C>T	c.(463-465)CCC>TCC	p.P155S	MYO9B_uc002nfi.2_Missense_Mutation_p.P155S|MYO9B_uc002nfj.1_Missense_Mutation_p.P155S	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	155	Myosin head-like.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GTGTAACCTCCCCGAGCTAAC	0.622													50	31					0	0	0.000781405	0	0
FAM129C	199786	broad.mit.edu	37	19	17654161	17654161	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:17654161G>A	uc010xpr.1	+	12	1596	c.1458G>A	c.(1456-1458)CTG>CTA	p.L486L	FAM129C_uc010xpq.1_Silent_p.L486L|FAM129C_uc002ngy.3_Silent_p.L212L|FAM129C_uc010xpu.1_Silent_p.L212L|FAM129C_uc002ngz.3_RNA|FAM129C_uc010eaw.2_Silent_p.L212L|FAM129C_uc002nhb.2_Silent_p.L85L	NM_173544	NP_775815	Q86XR2	NIBL2_HUMAN	B-cell novel protein 1 isoform a	486											0						TCCTGCAGCTGGCTGACCAGT	0.642													32	71					0	0	0.0024448	0	0
GDF15	9518	broad.mit.edu	37	19	18499352	18499352	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:18499352C>T	uc002niv.2	+	2	566	c.534C>T	c.(532-534)CCC>CCT	p.P178P		NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	178					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						CCGCACGGCCCCAGCTGGAGT	0.731											OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	11					0	0	0.00116845	0	0
SFRS14	10147	broad.mit.edu	37	19	19115180	19115180	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:19115180G>A	uc002nkx.2	-	7	2872	c.2726C>T	c.(2725-2727)CCT>CTT	p.P909L	SFRS14_uc002nkz.1_Missense_Mutation_p.P923L|SFRS14_uc002nla.1_Missense_Mutation_p.P909L|SFRS14_uc002nlb.2_Missense_Mutation_p.P909L|SFRS14_uc010xqk.1_Missense_Mutation_p.P678L	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	909					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			CGCCCCTCCAGGAGCGGGGGc	0.582													7	10					0	0	0.000157383	0	0
ZNF14	7561	broad.mit.edu	37	19	19823621	19823621	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:19823621G>A	uc002nnk.1	-	4	623	c.469C>T	c.(469-471)CGC>TGC	p.R157C		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	157	C2H2-type 2; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				TCATGTTTGCGAAAGCAGTGG	0.393													17	42					0	0	0.000958276	0	0
ZNF682	91120	broad.mit.edu	37	19	20117385	20117385	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:20117385C>T	uc002noq.2	-	4	1049	c.926G>A	c.(925-927)GGA>GAA	p.G309E	ZNF682_uc002noo.2_Missense_Mutation_p.G277E|ZNF682_uc002nop.2_Missense_Mutation_p.G277E|ZNF682_uc010eck.2_Missense_Mutation_p.G233E	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						GGGTTTCTTTCCAGTGTGAAT	0.403													50	46					0	0	0.000781405	0	0
ZNF486	90649	broad.mit.edu	37	19	20308600	20308600	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:20308600C>T	uc002nou.2	+	4	1138	c.1081C>T	c.(1081-1083)CGC>TGC	p.R361C		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	361	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGCCTTCACCCGCTCCTCACA	0.428													23	19					0	0	0.000586117	0	0
ZNF714	148206	broad.mit.edu	37	19	21300638	21300638	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:21300638C>T	uc002npo.3	+	6	1531	c.1171C>T	c.(1171-1173)CAT>TAT	p.H391Y	ZNF714_uc002npl.2_Missense_Mutation_p.H236Y|ZNF714_uc010ecp.1_Missense_Mutation_p.H342Y|ZNF714_uc002npn.2_RNA	NM_182515	NP_872321	Q96N38	ZN714_HUMAN	zinc finger protein 714	391	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAAGATAATTCATACTGGAGA	0.348													13	13					0	0	0.00185496	0	0
ZNF257	113835	broad.mit.edu	37	19	22271622	22271622	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:22271622C>T	uc010ecx.2	+	4	1239	c.1070C>T	c.(1069-1071)TCA>TTA	p.S357L	ZNF257_uc010ecy.2_Missense_Mutation_p.S325L	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	357	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				AACCGGTCTTCACACCTTACT	0.408													25	14					0	0	0.00047179	0	0
ZNF676	163223	broad.mit.edu	37	19	22375878	22375878	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:22375878G>A	uc002nqs.1	-	2	388	c.70C>T	c.(70-72)CTG>TTG	p.L24L		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	24	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CCTTGCTCCAGAAAAATGATC	0.403													38	23					0	0	0.00170553	0	0
Unknown	0	broad.mit.edu	37	19	24102171	24102171	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:24102171C>T	uc002nrp.1	-	3		c.1297G>A			uc010eda.1_Intron					Homo sapiens cDNA FLJ43698 fis, clone TCERX2000998.																		TGTGTATTTTCCAGGGACTGT	0.383													22	54					0	0	0.00106085	0	0
RGS9BP	388531	broad.mit.edu	37	19	33167846	33167846	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:33167846C>T	uc002ntp.1	+	1	1534	c.677C>T	c.(676-678)GCC>GTC	p.A226V	ANKRD27_uc002ntn.1_5'Flank|ANKRD27_uc002nto.1_5'Flank	NM_207391	NP_997274	Q6ZS82	R9BP_HUMAN	RGS9 anchor protein	226	Helical; Anchor for type IV membrane protein; (Potential).				negative regulation of signal transduction	integral to membrane				central_nervous_system(1)	1	Esophageal squamous(110;0.137)					GCGGCTGTGGCCCTAGCCGTG	0.706													12	8					0	0	0.000308642	0	0
KIAA0355	9710	broad.mit.edu	37	19	34838929	34838929	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:34838929C>T	uc002nvd.3	+	11	3528	c.2669C>T	c.(2668-2670)CCC>CTC	p.P890L		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	890										ovary(1)	1	Esophageal squamous(110;0.162)					TGGCCCTTCCCCGAGTTCTTC	0.657													10	13					0	0	0.000673444	0	0
SCN1B	6324	broad.mit.edu	37	19	35530543	35530543	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:35530543G>A	uc002nxp.2	+	5	786	c.595G>A	c.(595-597)GAA>AAA	p.E199K	SCN1B_uc010xsg.1_Missense_Mutation_p.E128K|HPN_uc002nxq.1_5'Flank|HPN_uc002nxr.1_5'Flank|HPN_uc002nxs.1_5'Flank	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	199	Cytoplasmic (Potential).				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CCACAGCTCGGAATACCTGGC	0.622													9	16					0	0	0.000673444	0	0
HPN	3249	broad.mit.edu	37	19	35551533	35551533	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:35551533G>A	uc002nxq.1	+	10	868	c.623G>A	c.(622-624)CGG>CAG	p.R208Q	HPN_uc002nxr.1_Missense_Mutation_p.R208Q|HPN_uc002nxs.1_Missense_Mutation_p.R50Q|HPN_uc010xsh.1_Missense_Mutation_p.R177Q|HPN_uc002nxt.1_Missense_Mutation_p.R92Q|LOC100128675_uc010xsi.1_Intron	NM_002151	NP_002142	P05981	HEPS_HUMAN	hepsin	208	Extracellular (Potential).|Peptidase S1.				cell growth|proteolysis	cytoplasm|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;5.38e-08)|Lung NSC(56;8.61e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)		Coagulation factor VIIa(DB00036)	CCTGGTAGGCGGAACCGGGTC	0.692													18	24					0	0	0.00188189	0	0
HAMP	57817	broad.mit.edu	37	19	35775857	35775857	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:35775857G>A	uc002nyw.2	+	3	238	c.167G>A	c.(166-168)CGA>CAA	p.R56Q		NM_021175	NP_066998	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide preproprotein	56					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			central_nervous_system(1)	1	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTCCAGAGGCGAAGGAGGCGA	0.582													37	44					0	0	0.00222228	0	0
COX6B1	1340	broad.mit.edu	37	19	36142191	36142191	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:36142191C>T	uc002oav.2	+	2	208	c.46C>T	c.(46-48)CCT>TCT	p.P16S		NM_001863	NP_001854	P14854	CX6B1_HUMAN	cytochrome c oxidase subunit VIb polypeptide 1	16					respiratory electron transport chain	mitochondrial inner membrane|mitochondrial intermembrane space	cytochrome-c oxidase activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAAGACCGCCCCTTTTGACAG	0.572													12	26					0	0	0.000308642	0	0
UPK1A	11045	broad.mit.edu	37	19	36168744	36168744	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:36168744G>A	uc002oaw.2	+	6	679	c.679G>A	c.(679-681)GAC>AAC	p.D227N	UPK1A_uc010eeh.2_Silent_p.S259S	NM_007000	NP_008931	O00322	UPK1A_HUMAN	uroplakin 1A	227	Extracellular (Potential).				epithelial cell differentiation|protein oligomerization	endoplasmic reticulum|integral to membrane	monosaccharide binding|protein homodimerization activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCACGCCATCGACAGCTACAC	0.627													6	16					0	0	0.00198382	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36278102	36278102	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:36278102C>T	uc002obs.1	+	21	2237	c.2152C>T	c.(2152-2154)CCC>TCC	p.P718S	ARHGAP33_uc002obt.1_Missense_Mutation_p.P743S|ARHGAP33_uc010eel.2_Missense_Mutation_p.P467S|ARHGAP33_uc002obv.1_Missense_Mutation_p.P467S	NM_052948	NP_443180	O14559	RHG33_HUMAN	sorting nexin 26	766					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			skin(2)|ovary(1)|pancreas(1)	4						GCCACCCCCTCCCCTGTCTCT	0.662													24	16					0	0	0.000878237	0	0
LRFN3	79414	broad.mit.edu	37	19	36431365	36431365	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:36431365C>T	uc002oco.2	+	2	1490	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F		NM_024509	NP_078785	Q9BTN0	LRFN3_HUMAN	leucine rich repeat and fibronectin type III	346	Extracellular (Potential).|Ig-like.				cell adhesion	axon|cell junction|dendrite|integral to membrane|postsynaptic membrane|presynaptic membrane					0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCCGCGCCTTCCCCAATGGGA	0.692													10	9					0	0	0.00136819	0	0
WDR62	284403	broad.mit.edu	37	19	36572341	36572341	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:36572341C>T	uc002odc.2	+	10	1331	c.1240C>T	c.(1240-1242)CCT>TCT	p.P414S	WDR62_uc002odd.2_Missense_Mutation_p.P414S	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	414	WD 6.				cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GTAGGTGTATCCTGAGTTTGA	0.428													57	91					0	0	0.000781405	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643784	37643785	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:37643784_37643785GG>AA	uc002ofo.1	-	5	1247_1248	c.1016_1017CC>TT	c.(1015-1017)TCC>TTT	p.S339F	ZNF585A_uc002ofm.1_Missense_Mutation_p.S284F|ZNF585A_uc002ofn.1_Missense_Mutation_p.S284F	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	339	C2H2-type 7; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TAACGAGGTTGGAATTATTGCT	0.401													28	56					0	0	6.4e-05	0	0
ZNF585A	199704	broad.mit.edu	37	19	37644020	37644020	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:37644020G>A	uc002ofo.1	-	5	1012	c.781C>T	c.(781-783)CAG>TAG	p.Q261*	ZNF585A_uc002ofm.1_Nonsense_Mutation_p.Q206*|ZNF585A_uc002ofn.1_Nonsense_Mutation_p.Q206*	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	261	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGGATTTTCTGATGCATCTTG	0.433													51	71					0	0	0.000781405	0	0
ZNF585A	199704	broad.mit.edu	37	19	37660790	37660790	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:37660790G>A	uc002ofo.1	-	2	254	c.23C>T	c.(22-24)CCT>CTT	p.P8L	ZNF585A_uc002ofm.1_5'UTR|ZNF585A_uc002ofn.1_5'UTR	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	8					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGATTTCTGAGGTGAGGTCCA	0.537													11	12					0	0	0.00136819	0	0
ZNF585B	92285	broad.mit.edu	37	19	37676170	37676170	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:37676170G>A	uc002ofq.2	-	5	2523	c.2269C>T	c.(2269-2271)CAG>TAG	p.Q757*	uc002ofp.1_5'Flank|ZNF585B_uc002ofr.1_Nonsense_Mutation_p.Q571*	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	zinc finger protein 585B	757	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACTGATTTCTGAACGAAGCCT	0.483													25	38					0	0	0.00178596	0	0
HKR1	284459	broad.mit.edu	37	19	37854458	37854458	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:37854458C>T	uc002ogb.2	+	6	2030	c.1761C>T	c.(1759-1761)GGC>GGT	p.G587G	HKR1_uc002ofx.2_Silent_p.G303G|HKR1_uc002ofy.2_Silent_p.G303G|HKR1_uc002oga.2_Silent_p.G569G|HKR1_uc010xto.1_Silent_p.G569G|HKR1_uc002ogc.2_Silent_p.G568G|HKR1_uc010xtp.1_Silent_p.G526G|HKR1_uc002ogd.2_Silent_p.G526G	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	587	C2H2-type 11.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTGGGCAAGGCTTTTGTGCTA	0.552													16	21					0	0	0.000422831	0	0
ZFP30	22835	broad.mit.edu	37	19	38127197	38127197	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:38127197G>A	uc002ogv.1	-	6	761	c.245C>T	c.(244-246)TCC>TTC	p.S82F	ZFP30_uc002ogw.1_Missense_Mutation_p.S82F|ZFP30_uc002ogx.1_Missense_Mutation_p.S82F|ZFP30_uc010xtt.1_Missense_Mutation_p.S81F	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	82					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTCATATCTGGATTCCAAATC	0.294													14	11					0	0	0.000422831	0	0
ZNF573	126231	broad.mit.edu	37	19	38229581	38229581	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:38229581G>A	uc002ohe.2	-	4	1832	c.1810C>T	c.(1810-1812)CAT>TAT	p.H604Y	ZNF573_uc010efs.2_Missense_Mutation_p.H517Y|ZNF573_uc002ohd.2_Missense_Mutation_p.H602Y|ZNF573_uc002ohf.2_Missense_Mutation_p.H546Y|ZNF573_uc002ohg.2_Missense_Mutation_p.H516Y	NM_152360	NP_689573	Q86YE8	ZN573_HUMAN	zinc finger protein 573	584	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			CCACCAGTATGAATTTTCTGA	0.388													23	29					0	0	0.00278032	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572680	38572680	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:38572680C>T	uc002ohk.2	+	3	984	c.475C>T	c.(475-477)CCC>TCC	p.P159S		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	159					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCCCCGGTCCCCCGGCAGGGC	0.711													22	21					0	0	0.00278032	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38655244	38655244	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:38655244C>T	uc002ohk.2	+	15	4415	c.3906C>T	c.(3904-3906)TCC>TCT	p.S1302S		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1302					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACCCCCTCTCCAAGGGTGGCT	0.657													8	17					0	0	0.000157383	0	0
RASGRP4	115727	broad.mit.edu	37	19	38912609	38912609	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:38912609C>T	uc002oir.2	-	2	422	c.208G>A	c.(208-210)GAT>AAT	p.D70N	RASGRP4_uc010efz.1_5'Flank|RASGRP4_uc010ega.1_5'Flank|RASGRP4_uc010xua.1_Missense_Mutation_p.D70N|RASGRP4_uc010xub.1_Missense_Mutation_p.D70N|RASGRP4_uc010xuc.1_Missense_Mutation_p.D70N|RASGRP4_uc010xud.1_Missense_Mutation_p.D70N|RASGRP4_uc010xue.1_Missense_Mutation_p.D70N|RASGRP4_uc010egb.2_Missense_Mutation_p.D70N	NM_170604	NP_733749	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4 isoform a	70	N-terminal Ras-GEF.				activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			pancreas(1)|lung(1)|skin(1)	3	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGACACTTACCGAAGGACTGG	0.403													3	8					0	0	6.4e-05	0	0
MAP4K1	11184	broad.mit.edu	37	19	39100614	39100614	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:39100614G>A	uc002oix.1	-	12	970	c.862C>T	c.(862-864)CTT>TTT	p.L288F	MAP4K1_uc002oiw.1_5'Flank|MAP4K1_uc002oiy.1_Missense_Mutation_p.L288F|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	288					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGTTTGTCAAGAAGATCCAGG	0.572													14	23					0	0	0.000422831	0	0
NCCRP1	342897	broad.mit.edu	37	19	39691087	39691087	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:39691087G>A	uc002okq.1	+	5	669	c.650G>A	c.(649-651)CGA>CAA	p.R217Q		NM_001001414	NP_001001414	Q6ZVX7	NCRP1_HUMAN	non-specific cytotoxic cell receptor protein 1	217	FBA.				protein catabolic process					ovary(1)	1						GTGGCCCCCCGAACTTCTGGG	0.667													37	45					0	0	0.00222228	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39911444	39911444	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:39911444C>T	uc010xuz.1	+	13	1676	c.1351C>T	c.(1351-1353)CCT>TCT	p.P451S	PLEKHG2_uc010xuy.1_Missense_Mutation_p.P392S|PLEKHG2_uc002olj.2_Missense_Mutation_p.P451S|PLEKHG2_uc010xva.1_Missense_Mutation_p.P258S	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	451					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			ACTTGGGTCTCCTCGACCTCG	0.562													20	33					0	0	0.00047179	0	0
FCGBP	8857	broad.mit.edu	37	19	40392521	40392521	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:40392521G>A	uc002omp.3	-	16	7991	c.7983C>T	c.(7981-7983)TTC>TTT	p.F2661F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	2661	VWFD 6.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGAGCCCACAGAACTCCTCCT	0.632													5	20					0	0	0.00116845	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541351	40541351	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:40541351G>A	uc002omu.2	-	5	1480	c.1415C>T	c.(1414-1416)CCC>CTC	p.P472L	ZNF780B_uc002omv.2_Missense_Mutation_p.P324L	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	472					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ACATTCAAAGGGTTTCCCACC	0.388													27	27					0	0	0.00127121	0	0
ZNF780A	284323	broad.mit.edu	37	19	40581424	40581424	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:40581424C>T	uc002omy.2	-	6	1150	c.925G>A	c.(925-927)GAA>AAA	p.E309K	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E309K|ZNF780A_uc010xvh.1_Missense_Mutation_p.E310K	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	309	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					ATCCCACATTCCTTACATACA	0.388													49	59					0	0	0.000781405	0	0
PRX	57716	broad.mit.edu	37	19	40901361	40901361	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:40901361G>A	uc002onr.2	-	7	3167	c.2898C>T	c.(2896-2898)CTC>CTT	p.L966L	PRX_uc002onq.2_Silent_p.L827L|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	966					axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGCCTTGGGGAGTGAGATGG	0.622													25	43					0	0	0.000586117	0	0
ATP1A3	478	broad.mit.edu	37	19	42474558	42474558	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:42474558G>A	uc002osg.2	-	17	2554	c.2400C>T	c.(2398-2400)ATC>ATT	p.I800I	ATP1A3_uc010xwf.1_Silent_p.I811I|ATP1A3_uc010xwg.1_Silent_p.I770I|ATP1A3_uc010xwh.1_Silent_p.I813I|ATP1A3_uc002osh.2_Silent_p.I800I	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	800	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TGCCCAGATCGATGCAGAGGA	0.647													15	14					0	0	0.000422831	0	0
PSG8	440533	broad.mit.edu	37	19	43268180	43268180	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:43268180G>A	uc002ouo.2	-	2	416	c.318C>T	c.(316-318)TCC>TCT	p.S106S	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Silent_p.S106S|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_5'UTR|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Silent_p.S106S|PSG8_uc002oum.3_Silent_p.S106S|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Silent_p.S106S	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	106	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				GGATCAGCAGGGATGCATTGG	0.428													89	125					0	0	0.000781405	0	0
PSG1	5669	broad.mit.edu	37	19	43382351	43382351	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:43382351C>T	uc002ovb.2	-	2	282	c.144G>A	c.(142-144)GGG>GGA	p.G48G	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Silent_p.G48G|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_RNA|PSG1_uc002our.1_Silent_p.G48G|PSG1_uc010eio.1_Silent_p.G48G|PSG1_uc002oux.1_5'UTR|PSG1_uc002ouy.1_Silent_p.G48G|PSG1_uc002ouz.1_Silent_p.G48G|PSG1_uc002ova.1_Silent_p.G48G|PSG1_uc002ovc.2_Silent_p.G48G|PSG1_uc002ovd.1_Silent_p.G48G	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	48	Ig-like V-type.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GAACATCCTTCCCCTCGGAAA	0.478													17	63					0	0	0.0024448	0	0
PSG6	5675	broad.mit.edu	37	19	43585319	43585319	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:43585319C>T	uc002ovi.2	-	2	237	c.144G>A	c.(142-144)GGG>GGA	p.G48G	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Silent_p.G48G|PSG2_uc002ovq.3_Silent_p.G48G|PSG2_uc010eiq.1_Silent_p.G48G|PSG2_uc002ovs.3_Silent_p.G48G|PSG2_uc002ovt.3_Silent_p.G48G			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	48	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GAACATCCTTCCCCTCGGAAA	0.478													8	110					0	0	0.000308642	0	0
PLAUR	5329	broad.mit.edu	37	19	44160715	44160716	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:44160715_44160716CC>TA	uc002oxf.1	-	4	617_618	c.387_388GG>TA	c.(385-390)AGGGGC>AGTAGC	p.129_130RG>SS	PLAUR_uc002oxd.1_Missense_Mutation_p.129_130RG>SS|PLAUR_uc002oxe.1_Missense_Mutation_p.124_125RG>SS|PLAUR_uc002oxg.1_Missense_Mutation_p.129_130RG>SS	NM_002659	NP_002650	Q03405	UPAR_HUMAN	plasminogen activator, urokinase receptor	129_130	UPAR/Ly6 2.				attachment of GPI anchor to protein|blood coagulation|C-terminal protein lipidation|cellular component movement|chemotaxis|fibrinolysis|regulation of proteolysis	anchored to membrane|cell surface|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|extrinsic to membrane|integral to membrane|plasma membrane	enzyme binding|U-plasminogen activator receptor activity			ovary(1)	1		Prostate(69;0.0153)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Streptokinase(DB00086)|Tenecteplase(DB00031)|Urokinase(DB00013)	TGGTGCCGGCCCCTCTCACAGC	0.604													19	34					0	0	6.4e-05	0	0
IRGC	56269	broad.mit.edu	37	19	44224036	44224036	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:44224036G>A	uc002oxh.2	+	2	1473	c.1326G>A	c.(1324-1326)AGG>AGA	p.R442R		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	442						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CAACCTGCAGGAAGCTCGGCC	0.597													11	20					0	0	0.000978159	0	0
ZNF283	284349	broad.mit.edu	37	19	44352446	44352446	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:44352446C>T	uc002oxr.3	+	7	1961	c.1693C>T	c.(1693-1695)CAT>TAT	p.H565Y	ZNF283_uc002oxp.3_Missense_Mutation_p.H426Y	NM_181845	NP_862828	Q8N7M2	ZN283_HUMAN	zinc finger protein 283	565					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TCAGAAAATTCATACCGGTGA	0.418													10	31					0	0	0.000673444	0	0
ZNF224	7767	broad.mit.edu	37	19	44611150	44611150	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:44611150G>A	uc002oyh.1	+	6	1139	c.837G>A	c.(835-837)CAG>CAA	p.Q279Q	uc002oyi.2_RNA	NM_013398	NP_037530	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	279	C2H2-type 4.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				AAGAACATCAGAGAATCCATA	0.423													23	35					0	0	0.00229938	0	0
ZNF233	353355	broad.mit.edu	37	19	44778806	44778806	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:44778806G>A	uc002oyz.1	+	5	2120	c.1993G>A	c.(1993-1995)GAT>AAT	p.D665N	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.D480N	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	665					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				GTTGTCTTCAGATTCATCAGA	0.408													16	12					0	0	0.000422831	0	0
CLPTM1	1209	broad.mit.edu	37	19	45495627	45495627	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:45495627C>T	uc002pai.2	+	13	1707	c.1692C>T	c.(1690-1692)CCC>CCT	p.P564P	CLPTM1_uc010xxf.1_Silent_p.P462P|CLPTM1_uc010xxg.1_Silent_p.P550P	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	564	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		TCAAGATGCCCGTTATGTACC	0.622													128	150					0	0	0.000781405	0	0
DMWD	1762	broad.mit.edu	37	19	46289281	46289281	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:46289281G>A	uc002pdj.1	-	3	1519	c.1473C>T	c.(1471-1473)TCC>TCT	p.S491S	DMWD_uc002pdk.1_Silent_p.S491S|DMWD_uc010eko.1_Silent_p.S176S	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	491					meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		TGTTGGAGCGGGACAGCGAGC	0.746													5	5					0	0	0.00116845	0	0
IGFL4	444882	broad.mit.edu	37	19	46543462	46543462	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:46543462T>C	uc002pdy.1	-	3	337	c.283A>G	c.(283-285)ATG>GTG	p.M95V		NM_001002923	NP_001002923	Q6B9Z1	IGFL4_HUMAN	IGF-like family member 4 precursor	95						extracellular region					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		TCTGGCTTCATGCCTGGGACC	0.592													21	35					0	0	0.00278032	0	0
HIF3A	64344	broad.mit.edu	37	19	46828875	46828875	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:46828875G>T	uc002peh.2	+	11	1448	c.1419G>T	c.(1417-1419)GAG>GAT	p.E473D	HIF3A_uc002peg.3_Missense_Mutation_p.E473D|HIF3A_uc010xxx.1_RNA|HIF3A_uc002pei.3_Missense_Mutation_p.E417D|HIF3A_uc002pej.1_Missense_Mutation_p.E404D|HIF3A_uc002pek.2_Missense_Mutation_p.E417D|HIF3A_uc010xxy.1_Missense_Mutation_p.E404D|HIF3A_uc002pel.2_Missense_Mutation_p.E471D|HIF3A_uc010xxz.1_Missense_Mutation_p.E422D	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	473	NTAD.|ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		AGGCAGTGGAGACAGATTTAG	0.512													40	54					6.1244e-12	2.09449e-11	0.00170553	1	0
C5AR1	728	broad.mit.edu	37	19	47823206	47823206	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:47823206G>A	uc002pgj.1	+	2	221	c.172G>A	c.(172-174)GTG>ATG	p.V58M		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	58	Helical; Name=1; (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CAATGCCCTGGTGGTCTGGGT	0.582													24	33					0	0	0.00127121	0	0
GLTSCR1	29998	broad.mit.edu	37	19	48185309	48185309	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:48185309C>T	uc002phh.3	+	7	2377	c.2183C>T	c.(2182-2184)CCT>CTT	p.P728L	GLTSCR1_uc002phi.3_Missense_Mutation_p.P486L	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	728							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		AGCGCCCCGCCTCCCGCCCAA	0.746													2	0					0	0	6.4e-05	0	0
GLTSCR1	29998	broad.mit.edu	37	19	48204647	48204647	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:48204647C>T	uc002phh.3	+	15	3852	c.3658C>T	c.(3658-3660)CGG>TGG	p.R1220W	GLTSCR1_uc002phi.3_Missense_Mutation_p.R978W	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1220							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		CGAGGGTCATCGGCTTCCCGG	0.682													3	5					0	0	6.4e-05	0	0
LIG1	3978	broad.mit.edu	37	19	48620928	48620929	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:48620928_48620929GG>AA	uc002pia.1	-	26	2669_2670	c.2549_2550CC>TT	c.(2548-2550)TCC>TTT	p.S850F	LIG1_uc010xze.1_Missense_Mutation_p.S543F|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.S782F|LIG1_uc010xzg.1_Missense_Mutation_p.S819F	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	850					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	TGGGAGAGAGGGAGAGGTCAGC	0.658								NER					6	16					0	0	6.4e-05	0	0
LIG1	3978	broad.mit.edu	37	19	48640929	48640929	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:48640929G>A	uc002pia.1	-	13	1224	c.1104C>T	c.(1102-1104)TCC>TCT	p.S368S	LIG1_uc010xze.1_Silent_p.S61S|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Silent_p.S300S|LIG1_uc010xzg.1_Silent_p.S337S|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	368					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	CAGCCCGGACGGACTCCAGCT	0.662								NER					4	15					0	0	0.00116845	0	0
TMEM143	55260	broad.mit.edu	37	19	48845857	48845857	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:48845857G>A	uc002pix.1	-	6	914	c.905C>T	c.(904-906)ACC>ATC	p.T302I	TMEM143_uc002piw.1_Intron|TMEM143_uc002piy.1_Missense_Mutation_p.T267I|TMEM143_uc010xzn.1_Missense_Mutation_p.T237I|TMEM143_uc010elw.1_Missense_Mutation_p.T202I|TMEM143_uc010xzo.1_Missense_Mutation_p.T92I	NM_018273	NP_060743	Q96AN5	TM143_HUMAN	transmembrane protein 143	302	Helical; (Potential).					integral to membrane|mitochondrion					0		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		CTTGAGGTCGGTTAGCACCAC	0.662													10	21					0	0	0.00136819	0	0
LMTK3	114783	broad.mit.edu	37	19	49000740	49000740	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:49000740C>T	uc002pjk.2	-	12	3673	c.3673G>A	c.(3673-3675)GAC>AAC	p.D1225N		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		TTGGGGGGGTCCCCGTCTCCG	0.711													11	18					0	0	0.00136819	0	0
LMTK3	114783	broad.mit.edu	37	19	49013377	49013377	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:49013377C>T	uc002pjk.2	-	4	351	c.351G>A	c.(349-351)GCG>GCA	p.A117A		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		AGGTCTCCTCCGCAGGGGGAG	0.622													6	12					0	0	0.00198382	0	0
FAM83E	54854	broad.mit.edu	37	19	49107041	49107042	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:49107041_49107042GG>AA	uc002pjn.2	-	4	950_951	c.885_886CC>TT	c.(883-888)CCCCCC>CCTTCC	p.P296S	SPACA4_uc002pjo.2_5'Flank	NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	hypothetical protein LOC54854	296										ovary(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GGTTTCTGGGGGGGCGCAGGTG	0.718													7	5					0	0	6.4e-05	0	0
NTF4	4909	broad.mit.edu	37	19	49565005	49565005	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:49565005C>T	uc002pmf.3	-	2	391	c.250G>A	c.(250-252)GAA>AAA	p.E84K	CGB7_uc010yah.1_Intron	NM_006179	NP_006170	P34130	NTF4_HUMAN	neurotrophin 5 preproprotein	84			E -> K (in a patient with primary open- angle glaucoma; uncertain pathological significance).		adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity				0		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GGTGCAGTTTCGCTCACCCCA	0.701													4	6					0	0	0.00116845	0	0
TRPM4	54795	broad.mit.edu	37	19	49671183	49671183	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:49671183C>T	uc002pmw.2	+	4	349	c.277C>T	c.(277-279)CTC>TTC	p.L93F	TRPM4_uc010emu.2_Missense_Mutation_p.L93F|TRPM4_uc010yak.1_Intron|TRPM4_uc002pmx.2_Intron|TRPM4_uc010emv.2_Intron|TRPM4_uc010yal.1_Intron	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	93	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GTTCCTCCGGCTCTCTGACCG	0.502													83	76					0	0	0.000781405	0	0
PRR12	57479	broad.mit.edu	37	19	50098089	50098089	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50098089C>T	uc002poo.3	+	4	497	c.497C>T	c.(496-498)TCG>TTG	p.S166L		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	579	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		CCAGTGCCCTCGTCCCTCAGC	0.672													7	31					0	0	0.00198382	0	0
SCAF1	58506	broad.mit.edu	37	19	50156105	50156105	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50156105C>T	uc002poq.2	+	7	2583	c.2459C>T	c.(2458-2460)TCA>TTA	p.S820L		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	820	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TCAGGCTCTTCATCCTCGTCG	0.622													8	39					0	0	0.000442599	0	0
TBC1D17	79735	broad.mit.edu	37	19	50385371	50385371	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50385371C>T	uc002pqo.2	+	6	753	c.601C>T	c.(601-603)CTG>TTG	p.L201L	TBC1D17_uc010enn.1_RNA|TBC1D17_uc010ybg.1_Silent_p.L168L|TBC1D17_uc002pqp.2_5'UTR|TBC1D17_uc002pqq.1_RNA|TBC1D17_uc002pqr.2_5'UTR|TBC1D17_uc002pqs.2_5'Flank	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	201						intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CTTCCACCACCTGCAGCTCTT	0.657													48	276					0	0	0.000781405	0	0
NUP62	23636	broad.mit.edu	37	19	50411714	50411714	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50411714G>A	uc002pqx.2	-	2	1455	c.1351C>T	c.(1351-1353)CTC>TTC	p.L451F	IL4I1_uc002pqv.1_Intron|IL4I1_uc010eno.1_Intron|IL4I1_uc002pqw.1_Intron|IL4I1_uc002pqu.1_Intron|NUP62_uc002pqy.2_Missense_Mutation_p.L451F|NUP62_uc002pqz.2_Missense_Mutation_p.L451F|NUP62_uc002pra.2_Missense_Mutation_p.L451F|NUP62_uc002prb.2_Missense_Mutation_p.L451F|NUP62_uc002prc.2_Missense_Mutation_p.L375F	NM_153719	NP_714941	P37198	NUP62_HUMAN	nucleoporin 62kDa	451	Potential.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding				0		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		ATGTCCTTGAGATCCTGGGCC	0.592													43	183					0	0	0.000680045	0	0
SIGLEC11	114132	broad.mit.edu	37	19	50461796	50461797	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50461796_50461797GG>AA	uc010ybh.1	-	8	1485_1486	c.1394_1395CC>TT	c.(1393-1395)TCC>TTT	p.S465F	SIGLEC11_uc010ybi.1_Intron	NM_052884	NP_443116	Q96RL6	SIG11_HUMAN	sialic acid binding Ig-like lectin 11 isoform 1	465	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding	p.S465A(1)		ovary(3)|central_nervous_system(2)|pancreas(1)	6		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00107)|OV - Ovarian serous cystadenocarcinoma(262;0.00517)		CAGCCTCCCAGGAGCAGGAGGG	0.698													6	24					0	0	6.4e-05	0	0
VRK3	51231	broad.mit.edu	37	19	50492947	50492947	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50492947G>A	uc002prg.2	-	11	1143	c.1045C>T	c.(1045-1047)CCT>TCT	p.P349S	VRK3_uc002prh.1_Missense_Mutation_p.P349S|VRK3_uc002pri.1_Missense_Mutation_p.P299S|VRK3_uc010ens.2_Missense_Mutation_p.P349S|VRK3_uc010ybl.1_Missense_Mutation_p.P299S|VRK3_uc010ybm.1_Missense_Mutation_p.P118S|VRK3_uc002prj.1_Missense_Mutation_p.P299S|VRK3_uc002prk.1_Missense_Mutation_p.P349S|VRK3_uc010ent.1_Missense_Mutation_p.P105S|VRK3_uc002prl.2_Missense_Mutation_p.P349S|VRK3_uc010ybn.1_3'UTR	NM_016440	NP_057524	Q8IV63	VRK3_HUMAN	vaccinia related kinase 3 isoform 1	349	Protein kinase.					nucleus	ATP binding|protein kinase activity			stomach(1)|skin(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		CCCTCGTGAGGGCTCCTGCTG	0.572													14	47					0	0	0.00244969	0	0
NAPSA	9476	broad.mit.edu	37	19	50863041	50863041	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50863041G>A	uc002prx.2	-	6	800	c.747C>T	c.(745-747)TTC>TTT	p.F249F	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	249					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		TGACTGGCACGAAGGTGAGGG	0.647													21	93					0	0	0.00278032	0	0
MYBPC2	4606	broad.mit.edu	37	19	50938457	50938457	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:50938457G>A	uc002psf.2	+	2	110	c.59G>A	c.(58-60)GGA>GAA	p.G20E		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	20					cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GCCCCCAAAGGAGCCCCCAAG	0.577													6	6					0	0	0.000157383	0	0
SHANK1	50944	broad.mit.edu	37	19	51218985	51218985	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:51218985G>A	uc002psx.1	-	3	481	c.462C>T	c.(460-462)TTC>TTT	p.F154F		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	154					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TCTTGTATCGGAACTGAGGTC	0.532													35	171					0	0	0.00195071	0	0
KLK6	5653	broad.mit.edu	37	19	51466678	51466678	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:51466678G>A	uc002pui.2	-	5	585	c.325C>T	c.(325-327)CTG>TTG	p.L109L	KLK6_uc010eoj.2_Intron|KLK6_uc002puh.2_Silent_p.L118L|KLK6_uc002puj.2_Silent_p.L2L|KLK6_uc010ycn.1_Silent_p.L2L|KLK6_uc002pul.2_Silent_p.L109L|KLK6_uc002pum.2_Silent_p.L2L	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	109	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		AGGCGCAACAGCATGATGTCC	0.597													57	13					0	0	0.000781405	0	0
KLK9	284366	broad.mit.edu	37	19	51509897	51509898	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:51509897_51509898GG>AA	uc002pux.1	-	3	369_370	c.282_283CC>TT	c.(280-285)TTCCCC>TTTTCC	p.P95S	KLK9_uc002puw.1_RNA|KLK9_uc010eol.1_Missense_Mutation_p.P66S|KLK9_uc002puv.1_5'Flank	NM_012315	NP_036447	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9 precursor	95	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		CCAGGGTGGGGGAAGAAGTCCG	0.604													13	62					0	0	6.4e-05	0	0
KLK11	11012	broad.mit.edu	37	19	51527368	51527368	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:51527368G>A	uc002pvd.1	-	4	604	c.492C>T	c.(490-492)TCC>TCT	p.S164S	KLK11_uc002pvb.1_Silent_p.S157S|KLK11_uc002pve.1_Silent_p.S21S|KLK11_uc002pvf.1_Silent_p.S132S|KLK11_uc002pvc.3_Silent_p.S132S|KLK11_uc010eom.2_3'UTR	NM_144947	NP_659196	Q9UBX7	KLK11_HUMAN	kallikrein 11 isoform 2 precursor	164	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		CACAGCGTGAGGAGAGGGTGA	0.622													11	16					0	0	0.00136819	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628498	51628498	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:51628498C>T	uc002pvu.2	+	1	334	c.267C>T	c.(265-267)GAC>GAT	p.D89D	SIGLEC9_uc010yct.1_Silent_p.D89D	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	89	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		AGACTCGGGACCGATTCCACC	0.552													21	99					0	0	0.00229938	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51650538	51650538	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:51650538G>A	uc002pvv.1	+	6	1254	c.1185G>A	c.(1183-1185)ATG>ATA	p.M395I	SIGLEC7_uc002pvw.1_Missense_Mutation_p.M302I|SIGLEC7_uc010eoq.1_RNA|SIGLEC7_uc010eor.1_Intron	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	395	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		ACATAGGCATGAAGGATGCAA	0.572													24	27					0	0	0.000878237	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51650568	51650568	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:51650568C>T	uc002pvv.1	+	6	1284	c.1215C>T	c.(1213-1215)GCC>GCT	p.A405A	SIGLEC7_uc002pvw.1_Silent_p.A312A|SIGLEC7_uc010eoq.1_RNA|SIGLEC7_uc010eor.1_Intron	NM_014385	NP_055200	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7 isoform 1	405	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			large_intestine(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		GGGGCTCAGCCTCTCAGGTGA	0.552													8	27					0	0	0.000274275	0	0
SIGLEC6	946	broad.mit.edu	37	19	52023467	52023467	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:52023467G>A	uc002pwy.2	-	8	1393	c.1231C>T	c.(1231-1233)CCT>TCT	p.P411S	SIGLEC6_uc002pwz.2_Missense_Mutation_p.P395S|SIGLEC6_uc002pxa.2_Missense_Mutation_p.P352L|SIGLEC6_uc010ydb.1_Missense_Mutation_p.P348S|SIGLEC6_uc010ydc.1_3'UTR|SIGLEC6_uc010eoz.1_Missense_Mutation_p.P330L	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	411	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GCCTCAGCAGGGTGGTCTGAA	0.512													63	262					0	0	0.000781405	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034212	52034212	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:52034212G>A	uc002pwy.2	-	3	591	c.429C>T	c.(427-429)GCC>GCT	p.A143A	SIGLEC6_uc002pwz.2_Silent_p.A143A|SIGLEC6_uc002pxa.2_Silent_p.A143A|SIGLEC6_uc010ydb.1_Silent_p.A96A|SIGLEC6_uc010ydc.1_Silent_p.A132A|SIGLEC6_uc010eoz.1_Intron|SIGLEC6_uc010epb.1_Silent_p.A96A|SIGLEC6_uc010epa.1_Silent_p.A132A	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	143	Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		TGTGGGTCAGGGCTGGTGAGG	0.622													49	49					0	0	0.000781405	0	0
FPR2	2358	broad.mit.edu	37	19	52272199	52272199	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:52272199C>T	uc002pxr.2	+	2	333	c.288C>T	c.(286-288)TTC>TTT	p.F96F	FPR2_uc002pxs.3_Silent_p.F96F|FPR2_uc010epf.2_Silent_p.F96F	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	96	Extracellular (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						TTGGCTGGTTCCTGTGTAAGT	0.478													30	129					0	0	0.00058488	0	0
FPR3	2359	broad.mit.edu	37	19	52327322	52327322	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:52327322C>T	uc002pxt.1	+	2	505	c.321C>T	c.(319-321)ATC>ATT	p.I107I		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	107	Helical; Name=3; (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						TGATAGACATCAACCTGTTTG	0.478													11	88					0	0	0.00136819	0	0
ZNF480	147657	broad.mit.edu	37	19	52825827	52825827	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:52825827C>T	uc010ydl.1	+	5	1394	c.1324C>T	c.(1324-1326)CTT>TTT	p.L442F	ZNF480_uc002pyv.2_Missense_Mutation_p.L365F|ZNF480_uc010ydm.1_Missense_Mutation_p.L399F|ZNF480_uc010epn.2_Missense_Mutation_p.L273F|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	442	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GTATTCAGGCCTTTCAGCCCA	0.393													35	157					0	0	0.00128727	0	0
ZNF528	84436	broad.mit.edu	37	19	52918976	52918976	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:52918976C>T	uc002pzh.2	+	7	1297	c.871C>T	c.(871-873)CAT>TAT	p.H291Y	ZNF528_uc002pzi.2_Missense_Mutation_p.H58Y	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	291	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TCAAAGAATTCATACTGGAGA	0.378													90	88					0	0	0.000781405	0	0
ZNF578	147660	broad.mit.edu	37	19	53014273	53014273	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53014273C>T	uc002pzp.3	+	6	883	c.639C>T	c.(637-639)TTC>TTT	p.F213F		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		ATAATTTTTTCCATTCATCAT	0.358													30	110					0	0	0.00106085	0	0
ZNF808	388558	broad.mit.edu	37	19	53056970	53056970	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53056970C>T	uc010epq.1	+	5	978	c.801C>T	c.(799-801)CTC>CTT	p.L267L	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	267	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		GTGGCAAGCTCTTTAATCACA	0.398													34	194					0	0	0.00058488	0	0
ZNF701	55762	broad.mit.edu	37	19	53085749	53085749	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53085749C>T	uc002pzs.1	+	4	564	c.437C>T	c.(436-438)TCG>TTG	p.S146L	ZNF701_uc010ydn.1_Missense_Mutation_p.S212L	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	zinc finger protein 701	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		AGCTTTCATTCGCATCTGCCT	0.408													24	122					0	0	0.00106085	0	0
ZNF28	7576	broad.mit.edu	37	19	53304241	53304241	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53304241A>C	uc002qad.2	-	4	977	c.857T>G	c.(856-858)CTC>CGC	p.L286R	ZNF28_uc002qac.2_Missense_Mutation_p.L233R|ZNF28_uc010eqe.2_Missense_Mutation_p.L232R	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	286	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		GTGAAGGAAGAGGGATGTATT	0.403													27	135					0	0	0.000720815	0	0
ZNF677	342926	broad.mit.edu	37	19	53740812	53740812	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53740812G>A	uc002qbf.1	-	5	1353	c.1168C>T	c.(1168-1170)CTT>TTT	p.L390F	ZNF677_uc002qbg.1_Missense_Mutation_p.L390F	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	390	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		TGTTGGGTAAGGCTTGAACGT	0.413													61	53					0	0	0.000781405	0	0
BIRC8	112401	broad.mit.edu	37	19	53793363	53793363	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53793363C>T	uc002qbk.2	-	1	1513	c.265G>A	c.(265-267)GGA>AGA	p.G89R		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	89					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		ACCAGAGCTCCCTCAAGTGAA	0.393													80	73					0	0	0.000781405	0	0
ZNF525	170958	broad.mit.edu	37	19	53884139	53884139	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53884139G>A	uc010eqn.2	+	4	392	c.199G>A	c.(199-201)GAA>AAA	p.E67K	ZNF525_uc002qbl.2_Intron|ZNF765_uc010ydx.1_Intron	NR_003699				Homo sapiens cDNA FLJ39718 fis, clone SMINT2013695.												0						TCAGTGGCAAGAAGATGAAAG	0.393													77	89					0	0	0.000781405	0	0
ZNF813	126017	broad.mit.edu	37	19	53994699	53994699	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:53994699C>T	uc002qbu.2	+	4	1341	c.1213C>T	c.(1213-1215)CAT>TAT	p.H405Y	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	405	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TCGTAGACTTCATACCGGAGA	0.408													14	70					0	0	0.000308642	0	0
LILRA2	11027	broad.mit.edu	37	19	55086256	55086256	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55086256G>A	uc002qgg.3	+	4	500	c.411G>A	c.(409-411)GGG>GGA	p.G137G	LILRA2_uc010ern.2_Silent_p.G137G|LILRA2_uc002qgf.2_Silent_p.G137G|LILRA2_uc010yfe.1_Silent_p.G137G|LILRA2_uc010yff.1_Silent_p.G125G|LILRA2_uc010ero.2_Silent_p.G125G|LILRA2_uc010yfg.1_Silent_p.G137G	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	137	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CCTTAGGAGGGAACGTGACCC	0.557													25	121					0	0	0.000586117	0	0
LILRP2	79166	broad.mit.edu	37	19	55221331	55221331	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55221331C>T	uc002qgs.1	+	1		c.1731C>T			LILRP2_uc002qgt.1_Intron	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						ACTCTTCTTTCCCTCCAGGCG	0.622													5	29					0	0	0.000602214	0	0
NCR1	9437	broad.mit.edu	37	19	55417934	55417934	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55417934G>A	uc002qib.2	+	3	162	c.124G>A	c.(124-126)GAA>AAA	p.E42K	NCR1_uc002qic.2_Missense_Mutation_p.E42K|NCR1_uc002qie.2_Missense_Mutation_p.E42K|NCR1_uc002qid.2_Intron|NCR1_uc002qif.2_Intron|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	42	Ig-like 1.|Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		GGTTCCAAAGGAAAAGCAAGT	0.547													73	57					0	0	0.000781405	0	0
NLRP7	199713	broad.mit.edu	37	19	55451005	55451005	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55451005G>A	uc002qih.3	-	4	1258	c.1182C>T	c.(1180-1182)TTC>TTT	p.F394F	NLRP7_uc002qig.3_Silent_p.F394F|NLRP7_uc002qii.3_Silent_p.F394F|NLRP7_uc010esk.2_Silent_p.F394F|NLRP7_uc010esl.2_Silent_p.F422F	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	394	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GGAAACGCAGGAACAGCCCCG	0.711													8	20					0	0	0.000274275	0	0
NLRP7	199713	broad.mit.edu	37	19	55451413	55451413	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55451413C>T	uc002qih.3	-	4	850	c.774G>A	c.(772-774)CTG>CTA	p.L258L	NLRP7_uc002qig.3_Silent_p.L258L|NLRP7_uc002qii.3_Silent_p.L258L|NLRP7_uc010esk.2_Silent_p.L258L|NLRP7_uc010esl.2_Silent_p.L286L	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	258	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		GTGGGACTTTCAGCTCATCAA	0.557													25	143					0	0	0.000586117	0	0
NLRP7	199713	broad.mit.edu	37	19	55451819	55451819	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55451819C>T	uc002qih.3	-	4	444	c.368G>A	c.(367-369)TGG>TAG	p.W123*	NLRP7_uc002qig.3_Nonsense_Mutation_p.W123*|NLRP7_uc002qii.3_Nonsense_Mutation_p.W123*|NLRP7_uc010esk.2_Nonsense_Mutation_p.W123*|NLRP7_uc010esl.2_Nonsense_Mutation_p.W151*	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	123							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TGAATTTCTCCATCCTTCCTT	0.408													391	153					0	0	0.000781405	0	0
SYT5	6861	broad.mit.edu	37	19	55689657	55689657	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55689657C>T	uc002qjm.1	-	2	1219	c.159G>A	c.(157-159)AAG>AAA	p.K53K	SYT5_uc002qjp.2_Intron|SYT5_uc002qjn.1_Silent_p.K53K|SYT5_uc002qjo.1_Silent_p.K53K	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	53	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		TCCGACAGCTCTTCCGGTAGA	0.617													5	53					0	0	0.00198382	0	0
IL11	3589	broad.mit.edu	37	19	55879926	55879926	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:55879926G>A	uc002qks.1	-	3	328	c.192C>T	c.(190-192)TTC>TTT	p.F64F	IL11_uc010yfx.1_5'UTR	NM_000641	NP_000632	P20809	IL11_HUMAN	interleukin 11 precursor	64					B cell differentiation|fat cell differentiation|megakaryocyte differentiation|negative regulation of hormone secretion|platelet activation|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity|growth factor activity|interleukin-11 receptor binding				0	Breast(117;0.191)	Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Oprelvekin(DB00038)	CGTCAGCTGGGAATTTGTCCC	0.667													14	33					0	0	0.000422831	0	0
NLRP9	338321	broad.mit.edu	37	19	56223323	56223323	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56223323G>A	uc002qly.2	-	8	2714	c.2686C>T	c.(2686-2688)CCG>TCG	p.P896S		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	896	LRR 6.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CGGGTGATCGGACACGTTTGC	0.547													38	15					0	0	0.00195071	0	0
NLRP9	338321	broad.mit.edu	37	19	56243522	56243522	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56243522T>C	uc002qly.2	-	2	1703	c.1675A>G	c.(1675-1677)ACC>GCC	p.T559A		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	559						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ATCACTTTGGTTACAAATTCT	0.333													15	81					0	0	0.000308642	0	0
NLRP4	147945	broad.mit.edu	37	19	56390197	56390197	+	Missense_Mutation	SNP	G	A	A	rs141409047		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56390197G>A	uc002qmd.3	+	9	3156	c.2734G>A	c.(2734-2736)GAT>AAT	p.D912N	NLRP4_uc002qmf.2_Missense_Mutation_p.D837N|NLRP4_uc010etf.2_Missense_Mutation_p.D687N	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	912							ATP binding	p.D912N(1)		ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTGCTGTAAGGATCTCGCGTC	0.542													7	48					0	0	0.000157383	0	0
NLRP13	126204	broad.mit.edu	37	19	56424369	56424369	+	Nonsense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56424369T>A	uc010ygg.1	-	5	839	c.814A>T	c.(814-816)AAA>TAA	p.K272*		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	272	NACHT.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TACCTTATTTTATGGCAGCTG	0.443													19	117					0	0	0.00074312	0	0
NLRP13	126204	broad.mit.edu	37	19	56436372	56436372	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56436372G>A	uc010ygg.1	-	2	374	c.349C>T	c.(349-351)CCA>TCA	p.P117S		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	117							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TCCTGGGTTGGATCTTGCAGC	0.443													38	32					0	0	0.000781405	0	0
NLRP8	126205	broad.mit.edu	37	19	56466362	56466362	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56466362C>T	uc002qmh.2	+	3	1009	c.938C>T	c.(937-939)TCT>TTT	p.S313F	NLRP8_uc010etg.2_Missense_Mutation_p.S313F	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	313	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTGCCTGGGTCTGTCCTACTG	0.507													94	47					0	0	0.000781405	0	0
ZNF583	147949	broad.mit.edu	37	19	56935651	56935651	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56935651C>T	uc010ygl.1	+	5	1789	c.1624C>T	c.(1624-1626)CAT>TAT	p.H542Y	ZNF583_uc002qnc.2_Missense_Mutation_p.H542Y|ZNF583_uc010ygm.1_Missense_Mutation_p.H542Y	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	542	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		TGAGAGAATTCATactatgga	0.204													10	62					0	0	0.000978159	0	0
USP29	57663	broad.mit.edu	37	19	57640713	57640713	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:57640713C>T	uc002qny.2	+	4	1026	c.670C>T	c.(670-672)CTC>TTC	p.L224F		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	224					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGATTTGAAACTCGGGCCTTC	0.363													67	46					0	0	0.000781405	0	0
USP29	57663	broad.mit.edu	37	19	57641411	57641411	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:57641411C>T	uc002qny.2	+	4	1724	c.1368C>T	c.(1366-1368)ATC>ATT	p.I456I		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	456					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCTCTCCATCAACCTGCACC	0.358													102	69					0	0	0.000781405	0	0
ZIM3	114026	broad.mit.edu	37	19	57646552	57646552	+	Missense_Mutation	SNP	G	A	A	rs150510557		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:57646552G>A	uc002qnz.1	-	5	1539	c.1153C>T	c.(1153-1155)CAT>TAT	p.H385Y		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	385	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H385Y(1)		pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCCCCAGTATGGATTTTTTTA	0.393													25	149					0	0	0.00047179	0	0
DUXA	503835	broad.mit.edu	37	19	57665801	57665801	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:57665801G>A	uc002qoa.1	-	6	639	c.594C>T	c.(592-594)TTC>TTT	p.F198F		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	198						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		TGGCTCCAGAGAAATGAGAGT	0.418													16	47					0	0	0.00074312	0	0
ZNF304	57343	broad.mit.edu	37	19	57867617	57867617	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:57867617C>T	uc010ygw.1	+	3	768	c.380C>T	c.(379-381)TCG>TTG	p.S127L	ZNF304_uc010etw.2_Missense_Mutation_p.S174L|ZNF304_uc010etx.2_Missense_Mutation_p.S85L	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	127	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		AGAAGATTCTCGTTCAGTGCA	0.483													13	57					0	0	0.00185496	0	0
ZNF17	7565	broad.mit.edu	37	19	57932645	57932645	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:57932645C>T	uc002qoo.1	+	3	2016	c.1785C>T	c.(1783-1785)TCC>TCT	p.S595S	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Silent_p.S597S	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	595	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		TGGACAGCTCCACACTCATTA	0.398													41	34					0	0	0.00195071	0	0
ZNF671	79891	broad.mit.edu	37	19	58234583	58234583	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:58234583C>T	uc002qpz.3	-	2	363	c.264G>A	c.(262-264)CTG>CTA	p.L88L	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Silent_p.L11L|ZNF671_uc010yhf.1_Intron	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	88	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GGACCTTACCCAGTGAGGCTA	0.468													61	54					0	0	0.000781405	0	0
ZNF418	147686	broad.mit.edu	37	19	58437585	58437585	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:58437585G>A	uc002qqs.1	-	4	2256	c.1964C>T	c.(1963-1965)TCA>TTA	p.S655L	ZNF418_uc010yhn.1_RNA|ZNF418_uc010yho.1_Missense_Mutation_p.S570L	NM_133460	NP_597717	Q8TF45	ZN418_HUMAN	zinc finger protein 418	655	C2H2-type 16.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TCGATGAAATGATTTTCCACA	0.413													21	113					0	0	0.00152264	0	0
C19orf18	147685	broad.mit.edu	37	19	58477955	58477955	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:58477955G>A	uc002qqv.2	-	4	418	c.314C>T	c.(313-315)TCG>TTG	p.S105L		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	hypothetical protein LOC147685 precursor	105	Helical; (Potential).					integral to membrane				ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		GGCTACGCTCGAAATTAAAAT	0.348													67	23					0	0	0.000781405	0	0
ZNF606	80095	broad.mit.edu	37	19	58511242	58511242	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:58511242G>A	uc002qqw.2	-	4	729	c.111C>T	c.(109-111)GCC>GCT	p.A37A	ZNF606_uc010yhp.1_Intron|ZNF606_uc002qqx.1_3'UTR|uc002qqy.1_5'Flank|uc002qqz.1_5'Flank	NM_025027	NP_079303	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	37					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		CCACGTGCCAGGCAGGATACT	0.597													47	13					0	0	0.000680045	0	0
ZNF324	25799	broad.mit.edu	37	19	58983383	58983383	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:58983383C>T	uc002qsw.1	+	4	1618	c.1524C>T	c.(1522-1524)ACC>ACT	p.T508T	ZNF324_uc002qsx.1_Silent_p.T285T	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	508					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCGAGAAGACCGTCCGGCGAT	0.677													11	56					0	0	0.000978159	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010865	59010865	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:59010865G>A	uc002qtc.2	-	7	1771	c.1661C>T	c.(1660-1662)ACC>ATC	p.T554I	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	554	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GGACCGGAAGGTGTCCCCGAG	0.657													18	58					0	0	0.00121646	0	0
TMEM18	129787	broad.mit.edu	37	2	669593	669593	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:669593C>T	uc002qwl.2	-	5	504	c.410G>A	c.(409-411)AGG>AAG	p.R137K	TMEM18_uc002qwk.2_RNA	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	137	Nuclear localization signal.|Potential.				cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		GTCttctttccttctcctttt	0.433													29	8					0	0	0.000878237	0	0
Unknown	0	broad.mit.edu	37	2	905540	905540	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:905540C>T	uc010ewg.2	-	1		c.43G>A			uc010ewh.1_Missense_Mutation_p.G136R					Homo sapiens cDNA FLJ46162 fis, clone TESTI4002520.																		TCCCGGCCTCCTCGCCTGCAC	0.617													40	393					0	0	0.000781405	0	0
SNTG2	54221	broad.mit.edu	37	2	1094073	1094073	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1094073C>T	uc002qwq.2	+	4	430	c.302C>T	c.(301-303)TCA>TTA	p.S101L	SNTG2_uc002qwp.2_RNA|SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	101	PDZ.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTCGTCATATCAAAAATATTC	0.378													21	48					0	0	0.00278032	0	0
SNTG2	54221	broad.mit.edu	37	2	1168827	1168827	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1168827C>T	uc002qwq.2	+	8	677	c.549C>T	c.(547-549)CTC>CTT	p.L183L	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	183					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CCTCTCCCCTCTTTGACAGCG	0.478													86	65					0	0	0.000781405	0	0
SNTG2	54221	broad.mit.edu	37	2	1168853	1168853	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1168853G>A	uc002qwq.2	+	8	703	c.575G>A	c.(574-576)GGA>GAA	p.G192E	SNTG2_uc010ewi.2_Intron	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	192					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CATCTGAACGGAAACTCCAGT	0.443													48	99					0	0	0.000781405	0	0
TPO	7173	broad.mit.edu	37	2	1488382	1488382	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1488382G>A	uc002qww.2	+	9	1444	c.1353G>A	c.(1351-1353)AGG>AGA	p.R451R	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Silent_p.R451R|TPO_uc002qwr.2_Silent_p.R451R|TPO_uc002qwx.2_Silent_p.R451R|TPO_uc010yio.1_Silent_p.R278R|TPO_uc010yip.1_Silent_p.R451R|TPO_uc002qwy.1_5'UTR|TPO_uc002qwz.2_RNA	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	451	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TCACCCTGAGGGATTACATCC	0.577													9	27					0	0	0.000673444	0	0
PXDN	7837	broad.mit.edu	37	2	1652195	1652195	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1652195C>T	uc002qxa.2	-	17	3421	c.3357G>A	c.(3355-3357)AGG>AGA	p.R1119R		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1119					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGAACAGCCCCCTGAGAAGCG	0.597													13	25					0	0	0.00185496	0	0
MYT1L	23040	broad.mit.edu	37	2	1893050	1893050	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1893050G>A	uc002qxe.2	-	16	3310	c.2483C>T	c.(2482-2484)CCC>CTC	p.P828L	MYT1L_uc002qxd.2_Missense_Mutation_p.P826L|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	828					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TATCCTCCGGGGTTTCATTTT	0.542													14	43					0	0	0.00121646	0	0
MYT1L	23040	broad.mit.edu	37	2	1906908	1906908	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1906908C>T	uc002qxe.2	-	14	2803	c.1976G>A	c.(1975-1977)CGA>CAA	p.R659Q	MYT1L_uc002qxd.2_Missense_Mutation_p.R657Q|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	659					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		AGCTATGGCTCGCTTGCCATA	0.488													48	39					0	0	0.000781405	0	0
MYT1L	23040	broad.mit.edu	37	2	1926499	1926499	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:1926499C>T	uc002qxe.2	-	10	1869	c.1042G>A	c.(1042-1044)GAG>AAG	p.E348K	MYT1L_uc002qxd.2_Missense_Mutation_p.E348K|MYT1L_uc010ewl.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	348					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGATTCCTCTCCTGCGGGTTG	0.572													27	19					0	0	0.00106085	0	0
IAH1	285148	broad.mit.edu	37	2	9621462	9621462	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:9621462C>T	uc002qzr.2	+	4	357	c.331C>T	c.(331-333)CTA>TTA	p.L111L	IAH1_uc002qzs.2_5'UTR|IAH1_uc002qzt.2_5'UTR|IAH1_uc010yiz.1_RNA	NM_001039613	NP_001034702	Q2TAA2	IAH1_HUMAN	isoamyl acetate-hydrolyzing esterase 1 homolog	111					lipid catabolic process		hydrolase activity, acting on ester bonds				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CGCTGCGAACCTAAAGAGCAT	0.488													30	20					0	0	0.00178596	0	0
NTSR2	23620	broad.mit.edu	37	2	11802346	11802346	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:11802346G>A	uc002rbq.3	-	2	719	c.645C>T	c.(643-645)TTC>TTT	p.F215F		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	215	Extracellular (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	AGGGGAGCACGAAGGACACCA	0.642													79	51					0	0	0.000781405	0	0
NBAS	51594	broad.mit.edu	37	2	15307360	15307360	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:15307360G>A	uc002rcc.1	-	52	6954	c.6928C>T	c.(6928-6930)CCA>TCA	p.P2310S	NBAS_uc002rcb.1_Missense_Mutation_p.P150S|NBAS_uc010exl.1_Missense_Mutation_p.P1382S|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	2310										ovary(2)|liver(1)|skin(1)	4						ACAATACGTGGATAGAAGGGA	0.547													35	9					0	0	0.00058488	0	0
HS1BP3	64342	broad.mit.edu	37	2	20840835	20840835	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:20840835C>T	uc002rdw.1	-	3	345	c.304G>A	c.(304-306)GAG>AAG	p.E102K	HS1BP3_uc002rdx.2_Missense_Mutation_p.E102K|HS1BP3_uc002rdy.2_Missense_Mutation_p.E102K	NM_022460	NP_071905	Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	102	PX.				cell communication		phosphatidylinositol binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGTCAGACTCCCCAACAAAC	0.547													48	101					0	0	0.000781405	0	0
APOB	338	broad.mit.edu	37	2	21224644	21224645	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:21224644_21224645GG>TT	uc002red.2	-	29	13777_13778	c.13649_13650CC>AA	c.(13648-13650)CCC>CAA	p.P4550Q		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4550					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCTTCATGTAGGGGTTCATGAC	0.356													11	555					0	0	6.4e-05	0	0
APOB	338	broad.mit.edu	37	2	21227176	21227176	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:21227176C>T	uc002red.2	-	28	12180	c.12052G>A	c.(12052-12054)GAC>AAC	p.D4018N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4018					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTAGAAAAGTCGTCATCTTCA	0.507													269	157					0	0	0.000781405	0	0
APOB	338	broad.mit.edu	37	2	21227542	21227543	+	Nonsense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:21227542_21227543CC>AA	uc002red.2	-	27	11921_11922	c.11793_11794GG>TT	c.(11791-11796)TTGGGA>TTTTGA	p.3931_3932LG>F*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3931_3932					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGTGTGTTCCCAAAACTGTAT	0.361													9	381					0	0	6.4e-05	0	0
APOB	338	broad.mit.edu	37	2	21227980	21227980	+	Silent	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:21227980G>T	uc002red.2	-	26	11888	c.11760C>A	c.(11758-11760)ACC>ACA	p.T3920T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3920					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGAACTGTACGGTTGAGCTGC	0.378													10	431					0.000978159	0.00330738	0.000978159	1	0
APOB	338	broad.mit.edu	37	2	21231540	21231540	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:21231540G>A	uc002red.2	-	26	8328	c.8200C>T	c.(8200-8202)CCT>TCT	p.P2734S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2734				Missing (in Ref. 15; AAA51758).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGAAGGTCAGGAACTTGAAAA	0.418													326	217					0	0	0.000781405	0	0
APOB	338	broad.mit.edu	37	2	21233672	21233673	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:21233672_21233673GG>TT	uc002red.2	-	26	6195_6196	c.6067_6068CC>AA	c.(6067-6069)CCA>AAA	p.P2023K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2023					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CACTTTAATTGGGGAGTCTAGT	0.426													13	511					0	0	6.4e-05	0	0
APOB	338	broad.mit.edu	37	2	21233797	21233797	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:21233797C>T	uc002red.2	-	26	6071	c.5943G>A	c.(5941-5943)TGG>TGA	p.W1981*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1981					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCTTGAGTTTCCAGGTGCCTG	0.468													386	241					0	0	0.000781405	0	0
NCOA1	8648	broad.mit.edu	37	2	24952581	24952581	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:24952581C>T	uc002rfk.2	+	15	3356	c.3098C>T	c.(3097-3099)TCA>TTA	p.S1033L	NCOA1_uc010eye.2_Missense_Mutation_p.S1033L|NCOA1_uc002rfi.2_Missense_Mutation_p.S882L|NCOA1_uc002rfj.2_Missense_Mutation_p.S1033L|NCOA1_uc002rfl.2_Missense_Mutation_p.S1033L	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1033									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGCTTTTTCACCTGGCATG	0.542			T	PAX3	alveolar rhadomyosarcoma								24	94					0	0	0.00047179	0	0
ADCY3	109	broad.mit.edu	37	2	25141596	25141596	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:25141596G>A	uc002rfs.3	-	1	460	c.261C>T	c.(259-261)CTC>CTT	p.L87L	ADCY3_uc010ykm.1_Silent_p.L87L	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	87	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					AGCAGTCAAAGAGGGCTGCAA	0.577													55	27					0	0	0.000781405	0	0
DNMT3A	1788	broad.mit.edu	37	2	25462016	25462016	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:25462016G>A	uc002rgc.2	-	20	2648	c.2391C>T	c.(2389-2391)AAC>AAT	p.N797N	DNMT3A_uc002rgd.2_Silent_p.N797N|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Silent_p.N608N	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	797					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACCGGGAAGGTTACCCCAGA	0.582			Mis|F|N|S		AML								18	12					0	0	0.00074312	0	0
OTOF	9381	broad.mit.edu	37	2	26702507	26702507	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:26702507C>T	uc002rhk.2	-	17	2054	c.1927G>A	c.(1927-1929)GAA>AAA	p.E643K	OTOF_uc002rhh.2_5'Flank|OTOF_uc002rhi.2_5'Flank|OTOF_uc002rhj.2_5'Flank	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	643	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCATCAACTTCGTTCCCATAG	0.627													12	49					0	0	0.000422831	0	0
C2orf53	339779	broad.mit.edu	37	2	27360020	27360021	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:27360020_27360021GG>AA	uc002rjb.2	-	3	1757_1758	c.1177_1178CC>TT	c.(1177-1179)CCT>TTT	p.P393F	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	393											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCAGGGCAAGGCCTGGGCTTC	0.584													45	38					0	0	6.4e-05	0	0
C2orf16	84226	broad.mit.edu	37	2	27803388	27803388	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:27803388G>A	uc002rkz.3	+	1	4000	c.3949G>A	c.(3949-3951)GAA>AAA	p.E1317K	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1317										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					TCCTTCTAGGGAATTAGCAGC	0.398													19	41					0	0	0.00121646	0	0
LTBP1	4052	broad.mit.edu	37	2	33468816	33468816	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:33468816G>A	uc002ros.2	+	10	1964	c.1964G>A	c.(1963-1965)GGA>GAA	p.G655E	LTBP1_uc002rot.2_Missense_Mutation_p.G329E|LTBP1_uc002rou.2_Missense_Mutation_p.G329E|LTBP1_uc002rov.2_Missense_Mutation_p.G329E|LTBP1_uc010ymz.1_Missense_Mutation_p.G329E|LTBP1_uc010yna.1_Missense_Mutation_p.G329E	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	655	EGF-like 3; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGCAAAATAGGATTTGGGCCG	0.383													57	32					0	0	0.000781405	0	0
DHX57	90957	broad.mit.edu	37	2	39029995	39029995	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:39029995G>A	uc002rrf.2	-	23	3978	c.3879C>T	c.(3877-3879)TTC>TTT	p.F1293F	DHX57_uc002rrd.3_Silent_p.F632F|DHX57_uc002rre.2_Silent_p.F726F	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1293							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				AGTCTCGGATGAATACTCGAC	0.483													81	57					0	0	0.000781405	0	0
TMEM178	130733	broad.mit.edu	37	2	39944248	39944248	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:39944248G>A	uc002rrt.2	+	4	776	c.751G>A	c.(751-753)GAA>AAA	p.E251K	TMEM178_uc010fam.1_Missense_Mutation_p.E205K	NM_152390	NP_689603	Q8NBL3	TM178_HUMAN	transmembrane protein 178 precursor	251	Extracellular (Potential).					integral to membrane					0		all_hematologic(82;0.248)				TGCTGATGTGGAACATGGTTA	0.483													58	118					0	0	0.000781405	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656542	40656542	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:40656542C>T	uc002rrx.2	-	1	903	c.879G>A	c.(877-879)GGG>GGA	p.G293G	SLC8A1_uc002rry.2_Silent_p.G293G|SLC8A1_uc002rrz.2_Silent_p.G293G|SLC8A1_uc002rsa.2_Silent_p.G293G|SLC8A1_uc002rsd.3_Silent_p.G293G|SLC8A1_uc002rsb.1_Silent_p.G293G|SLC8A1_uc010fan.1_Silent_p.G293G|SLC8A1_uc002rsc.1_Silent_p.G293G	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	293	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGACCACTTTCCCGTCCATTT	0.448													101	84					0	0	0.000781405	0	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48809238	48809238	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:48809238A>T	uc010yol.1	+	1	1513	c.1466A>T	c.(1465-1467)AAG>ATG	p.K489M	STON1_uc002rwo.3_Missense_Mutation_p.K489M|STON1_uc010fbm.2_Missense_Mutation_p.K489M|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.K489M|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.K489M	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	489					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CATTTTCATAAGTGTGTGAAT	0.378													18	55					0	0	0.00074312	0	0
EFEMP1	2202	broad.mit.edu	37	2	56098174	56098174	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:56098174C>T	uc002rzh.2	-	9	1415	c.1085G>A	c.(1084-1086)CGA>CAA	p.R362Q	EFEMP1_uc002rzi.2_Missense_Mutation_p.R362Q|EFEMP1_uc002rzj.2_Missense_Mutation_p.R362Q|EFEMP1_uc010ypc.1_Missense_Mutation_p.R224Q	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	362	Mediates interaction with TIMP3.|EGF-like 6; calcium-binding (Potential).				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACAAGGATTTCGTGGATAACA	0.413													30	24					0	0	0.00209593	0	0
SPRED2	200734	broad.mit.edu	37	2	65543943	65543943	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:65543943G>A	uc002sdr.3	-	5	1048	c.513C>T	c.(511-513)TCC>TCT	p.S171S	SPRED2_uc010fcw.2_Silent_p.S168S	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	171					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GGTGCTCACAGGATGTGGGAG	0.527													23	27					0	0	0.00278032	0	0
PROKR1	10887	broad.mit.edu	37	2	68872977	68872977	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:68872977G>A	uc010yqj.1	+	1	24	c.24G>A	c.(22-24)ATG>ATA	p.M8I	PROKR1_uc002ses.2_RNA	NM_138964	NP_620414	Q8TCW9	PKR1_HUMAN	G protein-coupled receptor 73	8	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(1)	1						TGGGGTTCATGGATGACAATG	0.547													49	65					0	0	0.000781405	0	0
PCBP1	5093	broad.mit.edu	37	2	70314983	70314983	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:70314983T>C	uc002sgf.2	+	1	399	c.108T>C	c.(106-108)GTT>GTC	p.V36V	ASPRV1_uc002sga.2_5'Flank|uc002sgb.1_5'Flank|uc002sgd.2_5'Flank|uc002sge.1_5'Flank	NM_006196	NP_006187	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	36	KH 1.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding				0						GGGAGTCGGTTAAGAGGATCC	0.527													56	78					0	0	0.000781405	0	0
EMX1	2016	broad.mit.edu	37	2	73160970	73160970	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:73160970G>A	uc002sin.1	+	3	1138	c.760G>A	c.(760-762)GAG>AAG	p.E254K	EMX1_uc002sim.1_Missense_Mutation_p.G206E	NM_004097	NP_004088	Q04741	EMX1_HUMAN	empty spiracles homolog 1	221						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GAAGCTGGAGGAGGAAGGGCC	0.597													25	38					0	0	0.00127121	0	0
CCT7	10574	broad.mit.edu	37	2	73474974	73474974	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:73474974C>T	uc002siz.2	+	7	805	c.703C>T	c.(703-705)CCC>TCC	p.P235S	CCT7_uc002sja.2_Missense_Mutation_p.P31S|CCT7_uc010yrf.1_Missense_Mutation_p.P191S|CCT7_uc010feu.2_Missense_Mutation_p.P193S|CCT7_uc010yrg.1_Missense_Mutation_p.P135S|CCT7_uc010yrh.1_Missense_Mutation_p.P107S|CCT7_uc010yri.1_Missense_Mutation_p.P148S	NM_006429	NP_006420	Q99832	TCPH_HUMAN	chaperonin containing TCP1, subunit 7 isoform a	235					'de novo' posttranslational protein folding		ATP binding|unfolded protein binding				0						GTACCACAATCCCAAGATTGC	0.433													27	28					0	0	0.000878237	0	0
EGR4	1961	broad.mit.edu	37	2	73518712	73518712	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:73518712C>T	uc010yrj.1	-	2	1718	c.1643G>A	c.(1642-1644)CGC>CAC	p.R548H	EGR4_uc010yrk.1_Missense_Mutation_p.R547H	NM_001965	NP_001956	Q05215	EGR4_HUMAN	early growth response 4	444						intracellular	nucleic acid binding|zinc ion binding				0						CGCGAAGCGGCGGCCGCACAC	0.662													20	29					0	0	0.00229938	0	0
SLC4A5	57835	broad.mit.edu	37	2	74492337	74492337	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:74492337G>A	uc002sko.1	-	4	458	c.456C>T	c.(454-456)CCC>CCT	p.P152P	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Silent_p.P152P|SLC4A5_uc010ffc.1_Silent_p.P152P|SLC4A5_uc002skp.1_Silent_p.P88P|SLC4A5_uc002sks.1_Silent_p.P152P	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	152	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						TGGACACGTGGGGCTTGCTCC	0.592													63	96					0	0	0.000781405	0	0
C2orf65	130951	broad.mit.edu	37	2	74803660	74803660	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:74803660G>A	uc002smy.2	-	6	972	c.855C>T	c.(853-855)GAC>GAT	p.D285D	C2orf65_uc010ysa.1_Silent_p.D285D|C2orf65_uc002smz.2_Silent_p.D285D|C2orf65_uc010ffp.2_Silent_p.D3D|C2orf65_uc002smx.2_Silent_p.D41D	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951	285					chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						CTCCTTTAGGGTCATCCATTC	0.512													27	27					0	0	0.000878237	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745953	77745953	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:77745953C>T	uc002snr.2	-	3	1457	c.1042G>A	c.(1042-1044)GAA>AAA	p.E348K	LRRTM4_uc002snq.2_Missense_Mutation_p.E348K|LRRTM4_uc002sns.2_Missense_Mutation_p.E348K|LRRTM4_uc002snt.2_Missense_Mutation_p.E349K	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	348	LRRCT.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CTAACCTTTTCACCCTGGATG	0.433													7	14					0	0	0.00198382	0	0
REG3G	130120	broad.mit.edu	37	2	79254218	79254218	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:79254218G>A	uc002snw.2	+	4	339	c.254G>A	c.(253-255)GGA>GAA	p.G85E	REG3G_uc002snx.2_Missense_Mutation_p.G85E|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	85	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						GGGGCTGAGGGATCCTTCGTG	0.552													60	56					0	0	0.000781405	0	0
REG1A	5967	broad.mit.edu	37	2	79349251	79349251	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:79349251G>T	uc002snz.2	+	4	424	c.321G>T	c.(319-321)AAG>AAT	p.K107N	REG1A_uc010ffx.1_3'UTR|REG1A_uc010ysd.1_Missense_Mutation_p.K107N	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	107	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						ACCCCAAAAAGGTAGGCTGCA	0.488													34	45					4.62619e-21	1.59088e-20	0.000814825	1	0
POLR1A	25885	broad.mit.edu	37	2	86272890	86272890	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:86272890G>A	uc002sqs.2	-	20	3115	c.2736C>T	c.(2734-2736)ATC>ATT	p.I912I	POLR1A_uc010ytb.1_Silent_p.I278I|POLR1A_uc002sqt.1_5'Flank	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	912					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						GCAGGCACGAGATCTGGAGGA	0.517													29	33					0	0	0.001512	0	0
RNF103	7844	broad.mit.edu	37	2	86831597	86831597	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:86831597A>T	uc002srn.2	-	4	2396	c.1427T>A	c.(1426-1428)TTT>TAT	p.F476Y	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Missense_Mutation_p.F337Y|uc002sro.2_Intron	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	476					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						TTCTACAGGAAAGTTCTGAAA	0.433													36	40					0	0	0.00283554	0	0
Unknown	0	broad.mit.edu	37	2	91679115	91679115	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:91679115C>T	uc010yua.1	+	1		c.29C>T								Homo sapiens clone CIC 03 anticardiolipin immunoglobulin light chain mRNA, partial cds.																		TCTCCATCCTCCCTGTCTGCA	0.438													24	319					0	0	0.00285205	0	0
ARID5A	10865	broad.mit.edu	37	2	97217808	97217808	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:97217808C>T	uc002swe.2	+	7	1643	c.1543C>T	c.(1543-1545)CCG>TCG	p.P515S	ARID5A_uc010yuq.1_Missense_Mutation_p.P463S|ARID5A_uc002swf.2_Missense_Mutation_p.P351S|ARID5A_uc002swg.2_Missense_Mutation_p.P463S	NM_212481	NP_997646	Q03989	ARI5A_HUMAN	AT rich interactive domain 5A	515					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding				0						CACTGGCACCCCGGGCCCCTT	0.721													29	19					0	0	0.00127121	0	0
TMEM131	23505	broad.mit.edu	37	2	98409346	98409346	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:98409346G>A	uc002syh.3	-	31	3876	c.3647C>T	c.(3646-3648)CCA>CTA	p.P1216L		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1216						integral to membrane				ovary(4)|central_nervous_system(2)	6						GTGGACCGATGGGCCACACTG	0.542													12	21					0	0	0.000978159	0	0
VWA3B	200403	broad.mit.edu	37	2	98709692	98709692	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:98709692A>G	uc002syo.2	+	2	401	c.137A>G	c.(136-138)AAG>AGG	p.K46R	VWA3B_uc010yvh.1_5'UTR|VWA3B_uc002syj.2_RNA|VWA3B_uc002syk.1_RNA|VWA3B_uc002syl.1_5'UTR|VWA3B_uc002sym.2_Missense_Mutation_p.K46R|VWA3B_uc002syn.1_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	46										ovary(3)|large_intestine(2)|skin(1)	6						CATGGGCTTAAGAGCAACAAA	0.453													43	43					0	0	0.0025221	0	0
VWA3B	200403	broad.mit.edu	37	2	98928305	98928305	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:98928305C>T	uc002syo.2	+	27	3809	c.3545C>T	c.(3544-3546)TCT>TTT	p.S1182F	VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.S839F|VWA3B_uc002syp.1_Missense_Mutation_p.S574F|VWA3B_uc002syq.1_Missense_Mutation_p.S458F|VWA3B_uc002syr.1_Missense_Mutation_p.S499F|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1182										ovary(3)|large_intestine(2)|skin(1)	6						GCGAGGAACTCTGCTTTCCTC	0.572													15	16					0	0	0.000566183	0	0
CNGA3	1261	broad.mit.edu	37	2	99013442	99013442	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:99013442G>A	uc002syt.2	+	8	2226	c.1809G>A	c.(1807-1809)CGG>CGA	p.R603R	CNGA3_uc002syu.2_Silent_p.R585R|CNGA3_uc010fij.2_Silent_p.R607R	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	603	cGMP.				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						AGAAAGGACGGCAGATCCTGA	0.602													18	15					0	0	0.00074312	0	0
LONRF2	164832	broad.mit.edu	37	2	100906787	100906787	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:100906787C>A	uc002tal.3	-	10	2493	c.1853G>T	c.(1852-1854)CGA>CTA	p.R618L	LONRF2_uc010yvs.1_RNA	NM_198461	NP_940863	Q1L5Z9	LONF2_HUMAN	LON peptidase N-terminal domain and ring finger	618	Lon.				proteolysis		ATP-dependent peptidase activity|zinc ion binding			large_intestine(1)|skin(1)	2						GCTTAGCACTCGGAACCGACT	0.448													47	71					2.14674e-31	7.40441e-31	0.000781405	1	0
IL1RL1	9173	broad.mit.edu	37	2	102958747	102958747	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:102958747G>A	uc002tbu.1	+	6	946	c.675G>A	c.(673-675)GTG>GTA	p.V225V	IL1RL1_uc010ywa.1_Silent_p.V108V|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Silent_p.V225V	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	225	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TAAAGGAAGTGGAAATTGGTA	0.378													37	50					0	0	0.00195071	0	0
IL18R1	8809	broad.mit.edu	37	2	103001405	103001405	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:103001405G>A	uc002tbw.3	+	7	906	c.756G>A	c.(754-756)GGG>GGA	p.G252G	IL18R1_uc010ywc.1_Silent_p.G252G|IL18R1_uc010ywd.1_Silent_p.G97G|IL18R1_uc010fiy.2_Silent_p.G252G	NM_003855	NP_003846	Q13478	IL18R_HUMAN	interleukin 18 receptor 1 precursor	252	Ig-like C2-type 3.|Extracellular (Potential).				innate immune response	integral to membrane|plasma membrane	interleukin-1 receptor activity			ovary(2)|pancreas(1)	3						GGATGTTCGGGGAAGAAAATG	0.328													64	73					0	0	0.000781405	0	0
C2orf40	84417	broad.mit.edu	37	2	106690397	106690397	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:106690397C>T	uc010fjf.2	+	3	291	c.183C>T	c.(181-183)TTC>TTT	p.F61F		NM_032411	NP_115787	Q9H1Z8	AUGN_HUMAN	esophageal cancer related gene 4 protein	61						extracellular region|transport vesicle					0						CCAAAGAATTCCTTGGCAGCC	0.517													92	109					0	0	0.000781405	0	0
RGPD4	285190	broad.mit.edu	37	2	108507182	108507182	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:108507182G>A	uc010ywk.1	+	23	5354	c.5272G>A	c.(5272-5274)GAA>AAA	p.E1758K	RGPD4_uc002tdu.2_Missense_Mutation_p.E945K|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1758					intracellular transport		binding			skin(2)	2						CAAAGGTGAGGAATAAAATGC	0.303													21	26					0	0	0.00106085	0	0
SLC5A7	60482	broad.mit.edu	37	2	108604612	108604612	+	Missense_Mutation	SNP	A	G	G	rs35029295		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:108604612A>G	uc002tdv.2	+	2	277	c.1A>G	c.(1-3)ATG>GTG	p.M1V	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.M1V|SLC5A7_uc010ywn.1_Intron	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	1	Cytoplasmic (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	TTAGATAAAAATGGCTTTCCA	0.413													14	71					0	0	0.000566183	0	0
MALL	7851	broad.mit.edu	37	2	110849340	110849340	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:110849340C>T	uc002tfk.2	-	2	887	c.113G>A	c.(112-114)GGG>GAG	p.G38E	MALL_uc010fju.2_Intron	NM_005434	NP_005425	Q13021	MALL_HUMAN	mal, T-cell differentiation protein-like	38	MARVEL.|Helical; (Potential).				cholesterol homeostasis	clathrin-coated vesicle|Golgi membrane|integral to membrane|membrane raft|plasma membrane	protein binding			ovary(1)|skin(1)	2				Epithelial(1;0.0546)|STAD - Stomach adenocarcinoma(1;0.18)		GACCAAGAACCCAAATATCTG	0.463													17	67					0	0	0.000720815	0	0
FBLN7	129804	broad.mit.edu	37	2	112922660	112922660	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:112922660C>T	uc002tho.1	+	3	589	c.318C>T	c.(316-318)ACC>ACT	p.T106T	FBLN7_uc002thn.2_Silent_p.T106T|FBLN7_uc010fki.1_Silent_p.T106T|FBLN7_uc010fkj.1_Silent_p.T106T	NM_153214	NP_694946	Q53RD9	FBLN7_HUMAN	fibulin 7 isoform 1	106	Sushi.				cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			ovary(1)|central_nervous_system(1)	2						TCCATTTTACCTGCAACCCTG	0.572													35	49					0	0	0.00058488	0	0
RGPD5	84220	broad.mit.edu	37	2	113127769	113127770	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:113127769_113127770GG>AA	uc002ths.1	-	23	5360_5361	c.5283_5284CC>TT	c.(5281-5286)TCCCGT>TCTTGT	p.R1762C	RGPD8_uc010fkk.1_Missense_Mutation_p.R1622C	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	1762					intracellular transport	cytoplasm	binding				0						CCAGAAGAACGGGAAGGATTTT	0.302													40	60					0	0	6.4e-05	0	0
RGPD5	84220	broad.mit.edu	37	2	113181836	113181836	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:113181836C>T	uc002ths.1	-	2	198	c.121G>A	c.(121-123)GAA>AAA	p.E41K	RGPD8_uc010fkk.1_Missense_Mutation_p.E15K|RGPD5_uc002tht.1_5'Flank|RGPD5_uc010yxm.1_Missense_Mutation_p.E41K	NM_005054	NP_005045	Q99666	RGPD5_HUMAN	RANBP2-like and GRIP domain containing 5 isoform	41	TPR 1.				intracellular transport	cytoplasm	binding				0						AGATCATATTCTTTAGCTTCA	0.244													22	64					0	0	0.00178596	0	0
IL1F8	27177	broad.mit.edu	37	2	113786584	113786584	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:113786584C>T	uc002tiq.1	-	4	297	c.193G>A	c.(193-195)GGA>AGA	p.G65R	IL1F8_uc002tir.1_Missense_Mutation_p.G65R	NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	65					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						CCCTTGATTCCCAGGTAAACC	0.418													45	50					0	0	0.00285205	0	0
PSD4	23550	broad.mit.edu	37	2	113943598	113943598	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:113943598C>T	uc002tjc.2	+	5	1577	c.1394C>T	c.(1393-1395)TCC>TTC	p.S465F	PSD4_uc002tjd.2_Missense_Mutation_p.S86F|PSD4_uc002tje.2_Missense_Mutation_p.S436F|PSD4_uc002tjf.2_Missense_Mutation_p.S86F	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	465					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						CCTGCATCGTCCCAGGAGGGC	0.612													27	35					0	0	0.00106085	0	0
MARCO	8685	broad.mit.edu	37	2	119699879	119699879	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:119699879G>A	uc002tln.1	+	1	135	c.3G>A	c.(1-3)ATG>ATA	p.M1I	MARCO_uc010yyf.1_5'UTR	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	1	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						GCTTGGCAATGAGAAATAAGA	0.458													17	17					0	0	0.000422831	0	0
SCTR	6344	broad.mit.edu	37	2	120252038	120252038	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:120252038C>T	uc002tma.2	-	2	385	c.159G>A	c.(157-159)CAG>CAA	p.Q53Q		NM_002980	NP_002971	P47872	SCTR_HUMAN	secretin receptor precursor	53	Extracellular (Potential).				digestion|excretion	integral to plasma membrane	secretin receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3					Secretin(DB00021)	GGTCTCCTGTCTGCTCTCTGG	0.602													15	20					0	0	0.00244969	0	0
SAP130	79595	broad.mit.edu	37	2	128774043	128774043	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:128774043G>A	uc002tpp.2	-	4	637	c.505C>T	c.(505-507)CCA>TCA	p.P169S	SAP130_uc002tpo.2_5'Flank|SAP130_uc010fmd.2_Missense_Mutation_p.P169S|SAP130_uc002tpq.1_Missense_Mutation_p.P143S	NM_024545	NP_078821	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa isoform b	169	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			ovary(2)|skin(2)	4	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		ACCTGCCCTGGAACCTTGGGG	0.527													35	37					0	0	0.000953801	0	0
SMPD4	55627	broad.mit.edu	37	2	130911935	130911935	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:130911935G>A	uc002tqq.1	-	16	2211	c.1691C>T	c.(1690-1692)TCC>TTC	p.S564F	SMPD4_uc002tqo.1_Missense_Mutation_p.S96F|SMPD4_uc002tqp.1_Missense_Mutation_p.S303F|SMPD4_uc010yzy.1_Missense_Mutation_p.S313F|SMPD4_uc010yzz.1_Missense_Mutation_p.S228F|SMPD4_uc002tqr.1_Missense_Mutation_p.S535F|SMPD4_uc002tqs.1_Missense_Mutation_p.S432F|SMPD4_uc002tqt.1_Missense_Mutation_p.S413F|SMPD4_uc010zaa.1_Missense_Mutation_p.S422F|SMPD4_uc010zab.1_Missense_Mutation_p.S462F|SMPD4_uc010zac.1_Missense_Mutation_p.S305F|SMPD4_uc010zad.1_Missense_Mutation_p.S200F	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	525					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CACCTTGAAGGAGGCATCAGT	0.647													9	12					0	0	0.000978159	0	0
FAM123C	205147	broad.mit.edu	37	2	131519766	131519766	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:131519766C>T	uc002trw.2	+	2	311	c.121C>T	c.(121-123)CCA>TCA	p.P41S	FAM123C_uc010fmv.2_Missense_Mutation_p.P41S|FAM123C_uc010fms.1_Missense_Mutation_p.P41S|FAM123C_uc010fmt.1_Missense_Mutation_p.P41S|FAM123C_uc010fmu.1_Missense_Mutation_p.P41S	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	41										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GTCAGTCCTTCCAGGAGGGCA	0.647													4	8					0	0	0.000602214	0	0
FAM123C	205147	broad.mit.edu	37	2	131520787	131520787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:131520787C>T	uc002trw.2	+	2	1332	c.1142C>T	c.(1141-1143)TCC>TTC	p.S381F	FAM123C_uc010fmv.2_Missense_Mutation_p.S381F|FAM123C_uc010fms.1_Missense_Mutation_p.S381F|FAM123C_uc010fmt.1_Missense_Mutation_p.S381F|FAM123C_uc010fmu.1_Missense_Mutation_p.S381F	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	381										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		GAATCCGTGTCCACAAGTGAC	0.637													16	20					0	0	0.000422831	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131897829	131897829	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:131897829C>T	uc002tsg.3	+	7	1073	c.513C>T	c.(511-513)CCC>CCT	p.P171P	PLEKHB2_uc002tsh.2_Intron|PLEKHB2_uc002tsj.3_Silent_p.P170P|PLEKHB2_uc002tsf.3_Silent_p.P179P|PLEKHB2_uc010zao.1_Silent_p.P121P|PLEKHB2_uc010zap.1_Intron|PLEKHB2_uc010zaq.1_Missense_Mutation_p.P127L|PLEKHB2_uc002tsi.3_Silent_p.P212P	NM_001100623	NP_001094093	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B	171						membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.0828)		ATGCCGTGCCCTACCAGTACC	0.502													18	15					0	0	0.00121646	0	0
POTEE	445582	broad.mit.edu	37	2	131976308	131976308	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:131976308G>A	uc002tsn.2	+	1	385	c.333G>A	c.(331-333)GGG>GGA	p.G111G	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	111							ATP binding				0						GCTGCAGGGGGAGCGGCAAGA	0.602													46	56					0	0	0.000781405	0	0
CCDC74A	90557	broad.mit.edu	37	2	132288190	132288190	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:132288190C>T	uc002tta.2	+	3	386	c.334C>T	c.(334-336)CCC>TCC	p.P112S	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	112										skin(1)	1						GGCCTCTGCTCCCTTGGGCGC	0.642													18	29					0	0	0.00178596	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489581	133489581	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:133489581G>A	uc002ttp.2	-	17	5546	c.5172C>T	c.(5170-5172)ACC>ACT	p.T1724T	NCKAP5_uc002ttq.2_Silent_p.T405T	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1724							protein binding				0						GGAGTGGAAAGGTTCCGATCC	0.532													18	21					0	0	0.00074312	0	0
NCKAP5	344148	broad.mit.edu	37	2	133751795	133751795	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:133751795C>T	uc002ttp.2	-	7	733	c.359G>A	c.(358-360)CGA>CAA	p.R120Q	NCKAP5_uc002ttq.2_Missense_Mutation_p.R120Q|NCKAP5_uc002tts.1_Missense_Mutation_p.R95Q	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	120	Potential.						protein binding				0						CAATAGATTTCGTACTGTTTC	0.348													6	14					0	0	0.00116845	0	0
LCT	3938	broad.mit.edu	37	2	136566074	136566074	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:136566074C>T	uc002tuu.1	-	8	3854	c.3843G>A	c.(3841-3843)CCG>CCA	p.P1281P		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1281	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCTCCGTGTTCGGATTGGTCA	0.488													72	132					0	0	0.000781405	0	0
THSD7B	80731	broad.mit.edu	37	2	137814319	137814319	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:137814319G>A	uc002tva.1	+	2	376	c.376G>A	c.(376-378)GAA>AAA	p.E126K	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.E16K	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGTTGCAAATGAAATATGCGA	0.522													57	76					0	0	0.000781405	0	0
THSD7B	80731	broad.mit.edu	37	2	137814638	137814638	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:137814638G>A	uc002tva.1	+	2	695	c.695G>A	c.(694-696)GGA>GAA	p.G232E	THSD7B_uc010zbj.1_RNA|THSD7B_uc002tvb.2_Missense_Mutation_p.G122E	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATCCAAGCGGAAGAACTGTT	0.393													65	101					0	0	0.000781405	0	0
THSD7B	80731	broad.mit.edu	37	2	137917850	137917850	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:137917850C>T	uc002tva.1	+	5	1344	c.1344C>T	c.(1342-1344)ATC>ATT	p.I448I	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.I338I	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCTGCAATATCCCTTGCTCTA	0.517													27	44					0	0	0.00127121	0	0
THSD7B	80731	broad.mit.edu	37	2	138414689	138414689	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:138414689G>A	uc002tva.1	+	23	4247	c.4247G>A	c.(4246-4248)CGA>CAA	p.R1416Q	THSD7B_uc010zbj.1_RNA	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		AATAACGAACGAACTGTATGG	0.413													29	33					0	0	0.001512	0	0
LRP1B	53353	broad.mit.edu	37	2	141709478	141709478	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:141709478G>A	uc002tvj.1	-	19	3891	c.2919C>T	c.(2917-2919)TTC>TTT	p.F973F	LRP1B_uc010fnl.1_Silent_p.F155F	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	973	Extracellular (Potential).|LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTGCATACGAATTGGGTTA	0.418										TSP Lung(27;0.18)			22	40					0	0	0.00047179	0	0
LRP1B	53353	broad.mit.edu	37	2	141946119	141946119	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:141946119C>T	uc002tvj.1	-	7	1856	c.884G>A	c.(883-885)CGA>CAA	p.R295Q	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	295	Extracellular (Potential).|LDL-receptor class B 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATAGAGATTTCGAGTGAGCCA	0.408										TSP Lung(27;0.18)			23	40					0	0	0.00278032	0	0
LRP1B	53353	broad.mit.edu	37	2	141986947	141986947	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:141986947G>A	uc002tvj.1	-	6	1627	c.655C>T	c.(655-657)CTT>TTT	p.L219F	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	219	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTCCATTAAGATAGAAAACC	0.289										TSP Lung(27;0.18)			32	30					0	0	0.00209593	0	0
MBD5	55777	broad.mit.edu	37	2	149226928	149226928	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:149226928C>T	uc002twm.3	+	9	2404	c.1416C>T	c.(1414-1416)TTC>TTT	p.F472F	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Silent_p.F472F|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	472						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATGGAAATTTCATGATGCCAC	0.512													26	27					0	0	0.000586117	0	0
MBD5	55777	broad.mit.edu	37	2	149243398	149243398	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:149243398C>T	uc002twm.3	+	11	3921	c.2933C>T	c.(2932-2934)CCA>CTA	p.P978L	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.P978L|MBD5_uc002two.2_Missense_Mutation_p.P236L|MBD5_uc002twp.2_Missense_Mutation_p.P28L	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	978						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATGTTTCCTCCAAATCAGCAA	0.433													36	41					0	0	0.000953801	0	0
NEB	4703	broad.mit.edu	37	2	152522714	152522714	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:152522714G>A	uc010fnx.2	-	41	5112	c.4921C>T	c.(4921-4923)CAG>TAG	p.Q1641*		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1641	Nebulin 42.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GCAACCTCCTGAGATTTCTTT	0.502													89	111					0	0	0.000781405	0	0
GALNT13	114805	broad.mit.edu	37	2	154801055	154801055	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:154801055G>A	uc002tyr.3	+	3	612	c.45G>A	c.(43-45)CTG>CTA	p.L15L	GALNT13_uc002tyt.3_Silent_p.L15L	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	15	Helical; Signal-anchor for type II membrane protein; (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CCACTTCGCTGATGTGGGTTC	0.418													67	72					0	0	0.000781405	0	0
KCNJ3	3760	broad.mit.edu	37	2	155711711	155711711	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:155711711C>T	uc002tyv.1	+	3	1587	c.1392C>T	c.(1390-1392)AGC>AGT	p.S464S	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	464	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	ATCCCATGAGCCAGTCTGTGG	0.448													36	30					0	0	0.00111076	0	0
CYTIP	9595	broad.mit.edu	37	2	158283904	158283904	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:158283904G>A	uc002tzj.1	-	6	577	c.505C>T	c.(505-507)CTG>TTG	p.L169L	CYTIP_uc010zcl.1_Silent_p.L63L	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	169	Interaction with CYTH1.|Potential.				regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						GTTCTTTTCAGAATCATTGTT	0.353													20	22					0	0	0.00229938	0	0
SLC4A10	57282	broad.mit.edu	37	2	162821560	162821560	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:162821560G>A	uc002ubx.3	+	23	3221	c.3037_splice	c.e23-1	p.V1013_splice	SLC4A10_uc002uby.3_Splice_Site_p.V983_splice|SLC4A10_uc010zcs.1_Splice_Site_p.V994_splice	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate						bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						ATTTACTTCAGGTGTTAGCCC	0.368													19	36					0	0	0.00074312	0	0
DPP4	1803	broad.mit.edu	37	2	162865131	162865131	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:162865131C>T	uc002ubz.2	-	22	2489	c.1928G>A	c.(1927-1929)GGA>GAA	p.G643E	DPP4_uc010fpb.2_Missense_Mutation_p.G319E	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	643	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	CACGCCACTTCCCGATCCCAG	0.463													50	60					0	0	0.000781405	0	0
IFIH1	64135	broad.mit.edu	37	2	163139026	163139026	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:163139026G>A	uc002uce.2	-	6	1378	c.1156C>T	c.(1156-1158)CGT>TGT	p.R386C		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	386	Helicase ATP-binding.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						CCAATAACACGATACCATTTC	0.338													20	25					0	0	0.00121646	0	0
IFIH1	64135	broad.mit.edu	37	2	163174366	163174367	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:163174366_163174367CG>AT	uc002uce.2	-	1	673_674	c.451_452CG>AT	c.(451-453)CGG>ATG	p.R151M	IFIH1_uc002ucf.2_Missense_Mutation_p.R151M	NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	151	CARD 2.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GACACCTACCCGGTTTCTGTCT	0.49													16	476					0	0	6.4e-05	0	0
KCNH7	90134	broad.mit.edu	37	2	163374525	163374525	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:163374525G>A	uc002uch.1	-	4	819	c.607C>T	c.(607-609)CCT>TCT	p.P203S	KCNH7_uc002uci.2_Missense_Mutation_p.P203S	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	203	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TCTTTTGTAGGAGACTTAAAA	0.443													43	71					0	0	0.000680045	0	0
SCN1A	6323	broad.mit.edu	37	2	166848475	166848475	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:166848475G>A	uc010zcz.1	-	26	5295	c.5277C>T	c.(5275-5277)ATC>ATT	p.I1759I		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1770	IV.|Helical; Name=S6 of repeat IV; (By similarity).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGGATATGATGATGTAACTGA	0.463													66	85					0	0	0.000781405	0	0
SCN1A	6323	broad.mit.edu	37	2	166901655	166901655	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:166901655G>A	uc010zcz.1	-	10	1578	c.1560C>T	c.(1558-1560)TTC>TTT	p.F520F	SCN1A_uc002udo.3_Silent_p.F389F|SCN1A_uc010fpk.2_Silent_p.F389F	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	520						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CAGATTTTTGGAATTCATCCT	0.438													95	119					0	0	0.000781405	0	0
XIRP2	129446	broad.mit.edu	37	2	168102710	168102710	+	Missense_Mutation	SNP	C	T	T	rs74627077		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:168102710C>T	uc002udx.2	+	8	4826	c.4808C>T	c.(4807-4809)GCT>GTT	p.A1603V	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A1428V|XIRP2_uc010fpq.2_Missense_Mutation_p.A1381V|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1428					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ATTATCAGGGCTGATCTCAGA	0.363													24	16					0	0	0.000586117	0	0
XIRP2	129446	broad.mit.edu	37	2	168107796	168107796	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:168107796G>A	uc002udx.2	+	8	9912	c.9894G>A	c.(9892-9894)AAG>AAA	p.K3298K	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.K3123K|XIRP2_uc010fpq.2_Silent_p.K3076K|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3123					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCATCCGCAAGGTTGCAGTGC	0.453													51	77					0	0	0.000781405	0	0
ABCB11	8647	broad.mit.edu	37	2	169780212	169780212	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:169780212C>T	uc002ueo.1	-	28	4012	c.3886G>A	c.(3886-3888)GAA>AAA	p.E1296K	ABCB11_uc010zda.1_Missense_Mutation_p.E714K|ABCB11_uc010zdb.1_Missense_Mutation_p.E772K	NM_003742	NP_003733	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP),	1296	Cytoplasmic (Potential).|ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			ovary(2)|large_intestine(2)|breast(1)	5					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GTCCCCTTTTCAATCACCACC	0.517													27	20					0	0	0.000878237	0	0
PDE11A	50940	broad.mit.edu	37	2	178592780	178592780	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:178592780C>T	uc002ulq.2	-	11	2227	c.1909G>A	c.(1909-1911)GTA>ATA	p.V637I	PDE11A_uc002ulp.2_Missense_Mutation_p.V193I|PDE11A_uc002ulr.2_Missense_Mutation_p.V387I|PDE11A_uc002uls.1_Missense_Mutation_p.V279I|PDE11A_uc002ult.1_Missense_Mutation_p.V387I|PDE11A_uc002ulu.1_Missense_Mutation_p.V279I	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	637					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			AATTTCTGTACCATCCCCAGC	0.353									Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				14	32					0	0	0.00244969	0	0
TTN	7273	broad.mit.edu	37	2	179427361	179427361	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179427361C>T	uc010zfg.1	-	275	76018	c.75794G>A	c.(75793-75795)GGA>GAA	p.G25265E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G18960E|TTN_uc010zfi.1_Missense_Mutation_p.G18893E|TTN_uc010zfj.1_Missense_Mutation_p.G18768E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26192							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTAAGAACATCCTTCTTGTAG	0.388													37	51					0	0	0.000814825	0	0
TTN	7273	broad.mit.edu	37	2	179428361	179428361	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179428361C>T	uc010zfg.1	-	275	75018	c.74794G>A	c.(74794-74796)GAA>AAA	p.E24932K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E18627K|TTN_uc010zfi.1_Missense_Mutation_p.E18560K|TTN_uc010zfj.1_Missense_Mutation_p.E18435K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25859							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.E18435K(1)		ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTCAATTTCGGTACCTCCG	0.478													72	110					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179467247	179467247	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179467247T>G	uc010zfg.1	-	232	47402	c.47178A>C	c.(47176-47178)AAA>AAC	p.K15726N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K9421N|TTN_uc010zfi.1_Missense_Mutation_p.K9354N|TTN_uc010zfj.1_Missense_Mutation_p.K9229N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16653							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGCTGGAGGTTTCCATCCTA	0.408													4	18					0	0	0.00024832	0	0
TTN	7273	broad.mit.edu	37	2	179476501	179476501	+	Silent	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179476501G>C	uc010zfg.1	-	217	43055	c.42831C>G	c.(42829-42831)TCC>TCG	p.S14277S	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.S7972S|TTN_uc010zfi.1_Silent_p.S7905S|TTN_uc010zfj.1_Silent_p.S7780S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15204							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATCTTCAATGGATAGGATTT	0.423													4	155					0	0	0.00116845	0	0
TTN	7273	broad.mit.edu	37	2	179567192	179567193	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179567192_179567193GG>TT	uc010zfg.1	-	104	26913_26914	c.26689_26690CC>AA	c.(26689-26691)CCA>AAA	p.P8897K	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P5558K|TTN_uc010fre.1_Missense_Mutation_p.P8K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9824							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATCGTCTGGGGTCACATTG	0.426													10	331					0	0	6.4e-05	0	0
TTN	7273	broad.mit.edu	37	2	179590525	179590525	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179590525C>T	uc010zfg.1	-	67	17016	c.16792G>A	c.(16792-16794)GAT>AAT	p.D5598N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D2259N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6525							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACACAAGTATCACTTCCCACT	0.373													42	79					0	0	0.000680045	0	0
TTN	7273	broad.mit.edu	37	2	179603052	179603052	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179603052C>T	uc010zfg.1	-	46	10620	c.10396G>A	c.(10396-10398)GAA>AAA	p.E3466K	TTN_uc010zfh.1_Missense_Mutation_p.E4539K|TTN_uc010zfi.1_Missense_Mutation_p.E4472K|TTN_uc010zfj.1_Missense_Mutation_p.E4347K|TTN_uc002umz.1_Missense_Mutation_p.E127K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4393							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTGCTACTTCCAGGGGTTCG	0.468													18	10					0	0	0.00152264	0	0
TTN	7273	broad.mit.edu	37	2	179615186	179615186	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179615186C>T	uc002unb.2	-	46	12165	c.11941G>A	c.(11941-11943)GAC>AAC	p.D3981N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTGGCATGTCATTGTTATAC	0.328													30	50					0	0	0.00178596	0	0
TTN	7273	broad.mit.edu	37	2	179648923	179648923	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:179648923G>A	uc010zfg.1	-	16	2873	c.2649C>T	c.(2647-2649)TTC>TTT	p.F883F	TTN_uc010zfh.1_Silent_p.F837F|TTN_uc010zfi.1_Silent_p.F837F|TTN_uc010zfj.1_Silent_p.F837F|TTN_uc002unb.2_Silent_p.F883F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	883							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTGTCAGCGAAGGGGAACT	0.537													46	58					0	0	0.000781405	0	0
SESTD1	91404	broad.mit.edu	37	2	180041227	180041227	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:180041227T>G	uc002uni.3	-	4	353	c.203A>C	c.(202-204)GAT>GCT	p.D68A		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	68	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTTTCTGCCATCCACAATCAC	0.348													16	26					0	0	0.000566183	0	0
ITGA4	3676	broad.mit.edu	37	2	182363425	182363425	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:182363425G>A	uc002unu.2	+	15	2379	c.1616G>A	c.(1615-1617)GGA>GAA	p.G539E	ITGA4_uc010frj.1_Missense_Mutation_p.G21E	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	539	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TCTTCTAATGGAACTTCTGAC	0.363													43	34					0	0	0.000680045	0	0
ITGA4	3676	broad.mit.edu	37	2	182392056	182392056	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:182392056C>T	uc002unu.2	+	22	3135	c.2372C>T	c.(2371-2373)TCA>TTA	p.S791L	ITGA4_uc010frj.1_Missense_Mutation_p.S273L|ITGA4_uc002unv.2_Missense_Mutation_p.S36L	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	791	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GTGTATGGATCAAATGATGAA	0.294													21	24					0	0	0.000720815	0	0
SSFA2	6744	broad.mit.edu	37	2	182783380	182783380	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:182783380C>T	uc002uoi.2	+	12	3165	c.2843C>T	c.(2842-2844)TCA>TTA	p.S948L	SSFA2_uc002uoh.2_Missense_Mutation_p.S948L|SSFA2_uc002uoj.2_Missense_Mutation_p.S948L|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.S795L|SSFA2_uc002uol.2_Missense_Mutation_p.S795L|SSFA2_uc002uom.2_Missense_Mutation_p.S416L	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	948						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			ACTCAGAAATCATCTGTTCTA	0.313													30	62					0	0	0.000692331	0	0
PDE1A	5136	broad.mit.edu	37	2	183095838	183095838	+	Silent	SNP	G	A	A	rs142773553		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:183095838G>A	uc002uos.2	-	6	570	c.486C>T	c.(484-486)TTC>TTT	p.F162F	PDE1A_uc010zfp.1_Silent_p.F58F|PDE1A_uc002uoq.1_Silent_p.F162F|PDE1A_uc010zfq.1_Silent_p.F162F|PDE1A_uc002uor.2_Silent_p.F146F|PDE1A_uc002uou.2_Silent_p.F128F	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	162					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			CAAATACATCGAAAGACCATT	0.328													58	84					0	0	0.000781405	0	0
FRZB	2487	broad.mit.edu	37	2	183723556	183723556	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:183723556G>A	uc002upa.1	-	2	702	c.484C>T	c.(484-486)CCT>TCT	p.P162S		NM_001463	NP_001454	Q92765	SFRP3_HUMAN	frizzled-related protein precursor	162					brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GAATCCATAGGAAAATCTGAA	0.343													70	89					0	0	0.000781405	0	0
COL3A1	1281	broad.mit.edu	37	2	189873725	189873725	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:189873725G>A	uc002uqj.1	+	48	3718	c.3601G>A	c.(3601-3603)GGA>AGA	p.G1201R		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1201	Nonhelical region (C-terminal).				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGTGGTGTTGGAGCCGCTGC	0.542													42	41					0	0	0.00195071	0	0
COL5A2	1290	broad.mit.edu	37	2	189931166	189931166	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:189931166G>A	uc002uqk.2	-	23	1788	c.1513C>T	c.(1513-1515)CCC>TCC	p.P505S	COL5A2_uc010frx.2_Intron	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	505					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCACCTCTGGGACCTCTTTTG	0.483													119	113					0	0	0.000781405	0	0
STAT4	6775	broad.mit.edu	37	2	192012914	192012914	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:192012914G>A	uc002usm.1	-	2	270	c.16C>T	c.(16-18)CAA>TAA	p.Q6*	STAT4_uc010zgm.1_RNA|STAT4_uc010zgn.1_RNA|STAT4_uc010zgo.1_RNA|STAT4_uc002usn.1_Nonsense_Mutation_p.Q6*|STAT4_uc002uso.2_Nonsense_Mutation_p.Q6*|STAT4_uc002usp.3_Nonsense_Mutation_p.Q6*|STAT4_uc010zgl.1_Nonsense_Mutation_p.Q6*	NM_003151	NP_003142	Q14765	STAT4_HUMAN	signal transducer and activator of transcription	6					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(3)|skin(2)|lung(1)|ovary(1)|prostate(1)|pancreas(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			TGTTGGACTTGATTCCACTGA	0.358													38	70					0	0	0.00222228	0	0
SDPR	8436	broad.mit.edu	37	2	192700920	192700920	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:192700920C>T	uc002utb.2	-	2	1337	c.1007G>A	c.(1006-1008)GGT>GAT	p.G336D		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	336						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TTCGGAATGACCCTCTGCAAA	0.572													60	69					0	0	0.000781405	0	0
DNAH7	56171	broad.mit.edu	37	2	196774785	196774785	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:196774785C>T	uc002utj.3	-	25	4171	c.4070G>A	c.(4069-4071)GGG>GAG	p.G1357E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1357	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						ATAATCCAACCCATCAGAGCA	0.408													15	37					0	0	0.00244969	0	0
DNAH7	56171	broad.mit.edu	37	2	196822153	196822153	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:196822153G>A	uc002utj.3	-	19	3011	c.2910C>T	c.(2908-2910)CTC>CTT	p.L970L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	970	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GAAGCAGTAGGAGCTTGCCCT	0.458													23	22					0	0	0.000586117	0	0
PLCL1	5334	broad.mit.edu	37	2	198948707	198948707	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:198948707G>A	uc010fsp.2	+	2	757	c.466G>A	c.(466-468)GCC>ACC	p.A156T	PLCL1_uc002uuv.3_Missense_Mutation_p.A77T	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	156	PH.|Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CCTCGAGAAAGCCAAGCTTGA	0.453													44	53					0	0	0.00195071	0	0
PLCL1	5334	broad.mit.edu	37	2	198950799	198950799	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:198950799G>A	uc010fsp.2	+	2	2849	c.2558G>A	c.(2557-2559)GGA>GAA	p.G853E	PLCL1_uc002uuv.3_Missense_Mutation_p.G774E	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	853					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CGAAGTGGAGGAGGAAAGGCA	0.463													19	22					0	0	0.00121646	0	0
SGOL2	151246	broad.mit.edu	37	2	201436643	201436643	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:201436643C>T	uc002uvw.2	+	7	1687	c.1574C>T	c.(1573-1575)TCC>TTC	p.S525F	SGOL2_uc010zhd.1_Missense_Mutation_p.S525F|SGOL2_uc010zhe.1_Missense_Mutation_p.S525F	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	525					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						GGTCAGAATTCCCTAACTTGT	0.323													101	81					0	0	0.000781405	0	0
AOX1	316	broad.mit.edu	37	2	201473810	201473810	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:201473810C>T	uc002uvx.2	+	11	1112	c.1011C>T	c.(1009-1011)CTC>CTT	p.L337L	AOX1_uc010zhf.1_5'Flank|AOX1_uc010fsu.2_5'Flank	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	337	FAD-binding PCMH-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	ACCATGCTCTCCTGAAGCATT	0.512													33	28					0	0	0.00283554	0	0
AOX1	316	broad.mit.edu	37	2	201507454	201507454	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:201507454C>T	uc002uvx.2	+	25	2878	c.2777C>T	c.(2776-2778)CCT>CTT	p.P926L	AOX1_uc010zhf.1_Missense_Mutation_p.P482L|AOX1_uc010fsu.2_Missense_Mutation_p.P292L	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	926					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTTGGCTTTCCTCAGGCAGCG	0.483													62	46					0	0	0.000781405	0	0
CLK1	1195	broad.mit.edu	37	2	201718127	201718127	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:201718127G>T	uc002uwe.2	-	13	1538	c.1357C>A	c.(1357-1359)CTC>ATC	p.L453I	CLK1_uc002uwd.2_Missense_Mutation_p.L276I|CLK1_uc010zhi.1_Missense_Mutation_p.L495I|CLK1_uc002uwf.2_Missense_Mutation_p.L227I|CLK1_uc002uwg.2_Missense_Mutation_p.L302I|CLK1_uc010fsv.2_RNA	NM_004071	NP_004062	P49759	CLK1_HUMAN	CDC-like kinase 1 isoform 1	453	Protein kinase.				cell proliferation	nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			pancreas(2)	2						TTCTGAATGAGGTCAAAGAGA	0.363													54	45					4.6707e-30	1.6103e-29	0.000781405	1	0
NDUFB3	4709	broad.mit.edu	37	2	201950311	201950311	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:201950311C>T	uc002uwx.3	+	3	593	c.270C>T	c.(268-270)TCC>TCT	p.S90S		NM_002491	NP_002482	O43676	NDUB3_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	90					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	ACCTGGAGTCCCTGAATAAAG	0.373													34	27					0	0	0.0025221	0	0
CASP8	841	broad.mit.edu	37	2	202137459	202137459	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:202137459C>A	uc002uxr.1	+	5	719	c.510C>A	c.(508-510)AGC>AGA	p.S170R	CASP8_uc010ftc.1_Missense_Mutation_p.S170R|CASP8_uc002uxo.1_Missense_Mutation_p.S170R|CASP8_uc002uxp.1_Missense_Mutation_p.S202R|CASP8_uc002uxq.1_Missense_Mutation_p.S170R|CASP8_uc002uxs.1_Missense_Mutation_p.S170R|CASP8_uc002uxt.1_Missense_Mutation_p.S229R|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Missense_Mutation_p.S67R|CASP8_uc002uxv.1_Missense_Mutation_p.S170R|CASP8_uc002uxw.1_Missense_Mutation_p.S170R|CASP8_uc002uxy.1_Missense_Mutation_p.S170R|CASP8_uc002uxx.1_Missense_Mutation_p.S170R|CASP8_uc010ftf.2_Missense_Mutation_p.S170R|CASP8_uc010fte.1_Missense_Mutation_p.S67R	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	170	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TCAACAAGAGCCTGCTGAAGA	0.428										HNSCC(4;0.00038)			32	164					1.836e-18	6.30033e-18	0.000692331	1	0
NBEAL1	65065	broad.mit.edu	37	2	203972603	203972604	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:203972603_203972604GG>TT	uc002uzt.3	+	13	1887_1888	c.1554_1555GG>TT	c.(1552-1557)TTGGGG>TTTTGG	p.518_519LG>FW		NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	518_519							binding			ovary(1)|skin(1)	2						ATGGTTCCTTGGGGAGTCAGTC	0.46													13	607					0	0	6.4e-05	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171024	207171024	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:207171024C>T	uc002vbp.2	+	5	2022	c.1772C>T	c.(1771-1773)TCA>TTA	p.S591L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	591							nucleic acid binding|zinc ion binding			ovary(3)	3						TCTCTTGAGTCAGTAGTTGAT	0.403													15	22					0	0	0.000308642	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171067	207171067	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:207171067G>A	uc002vbp.2	+	5	2065	c.1815G>A	c.(1813-1815)CTG>CTA	p.L605L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	605							nucleic acid binding|zinc ion binding			ovary(3)	3						GAAGAAACCTGAAAGGTAGAC	0.398													26	31					0	0	0.000720815	0	0
LOC200726	200726	broad.mit.edu	37	2	207509180	207509180	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:207509180G>A	uc010fuh.1	+	2	395	c.220G>A	c.(220-222)GAT>AAT	p.D74N		NM_001102659	NP_001096129			hypothetical protein LOC200726												0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.115)|Lung(261;0.133)		AGGCTTCTGGGATTTTATGAT	0.493													16	12					0	0	0.000422831	0	0
MAP2	4133	broad.mit.edu	37	2	210595033	210595033	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:210595033C>T	uc002vde.1	+	15	5644	c.5396C>T	c.(5395-5397)TCG>TTG	p.S1799L	MAP2_uc002vdd.1_Missense_Mutation_p.S531L|MAP2_uc002vdf.1_Missense_Mutation_p.S474L|MAP2_uc002vdg.1_Missense_Mutation_p.S443L|MAP2_uc002vdh.1_Missense_Mutation_p.S500L|MAP2_uc002vdi.1_Missense_Mutation_p.S1795L	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1799					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AATGTCTCCTCGTCTGGAAGC	0.542													20	25					0	0	0.00188189	0	0
FN1	2335	broad.mit.edu	37	2	216251457	216251457	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:216251457T>A	uc002vfa.2	-	28	4833	c.4567A>T	c.(4567-4569)AAT>TAT	p.N1523Y	FN1_uc002vfb.2_Missense_Mutation_p.N1432Y|FN1_uc002vfc.2_Missense_Mutation_p.N1432Y|FN1_uc002vfd.2_Missense_Mutation_p.N1523Y|FN1_uc002vfe.2_Missense_Mutation_p.N1432Y|FN1_uc002vff.2_Missense_Mutation_p.N1432Y|FN1_uc002vfg.2_Missense_Mutation_p.N1432Y|FN1_uc002vfh.2_Missense_Mutation_p.N1432Y|FN1_uc002vfi.2_Missense_Mutation_p.N1523Y|FN1_uc002vfj.2_Missense_Mutation_p.N1523Y|FN1_uc002vez.2_5'UTR|FN1_uc010zjp.1_Missense_Mutation_p.N150Y	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCTGCCATTAAGAGCAACG	0.488													16	36					0	0	0.000566183	0	0
USP37	57695	broad.mit.edu	37	2	219346947	219346947	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:219346947G>A	uc002vie.2	-	17	2134	c.1681C>T	c.(1681-1683)CTC>TTC	p.L561F	USP37_uc010fvs.1_Missense_Mutation_p.L561F|USP37_uc010zkf.1_Missense_Mutation_p.L561F|USP37_uc002vif.2_Missense_Mutation_p.L561F|USP37_uc002vig.2_Missense_Mutation_p.L489F	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	561					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TTCAAATGGAGAATGAGGACC	0.383													19	51					0	0	0.00229938	0	0
STK36	27148	broad.mit.edu	37	2	219561263	219561263	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:219561263C>T	uc002viu.2	+	22	2791	c.2525C>T	c.(2524-2526)CCA>CTA	p.P842L	STK36_uc002viv.2_Intron|STK36_uc002viw.2_Missense_Mutation_p.P21L|STK36_uc002vix.2_5'UTR	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	842					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CGGTTGACTCCACCAGGTAGT	0.498													49	38					0	0	0.000781405	0	0
ATG9A	79065	broad.mit.edu	37	2	220089007	220089007	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:220089007G>A	uc002vke.1	-	8	1272	c.1086C>T	c.(1084-1086)TCC>TCT	p.S362S	ATG9A_uc002vkd.1_RNA|ATG9A_uc002vkf.1_Silent_p.S362S	NM_001077198	NP_001070666	Q7Z3C6	ATG9A_HUMAN	APG9 autophagy 9-like 1	362	Lumenal (By similarity).				autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCATGTACTTGGAGGCGGGCT	0.577													37	80					0	0	0.000814825	0	0
SPEG	10290	broad.mit.edu	37	2	220354580	220354580	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:220354580G>A	uc010fwg.2	+	36	8840	c.8840G>A	c.(8839-8841)CGA>CAA	p.R2947Q		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2947	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGCAGTCCCCGAAGCTCTCCC	0.657													22	14					0	0	0.00278032	0	0
CHPF	79586	broad.mit.edu	37	2	220406679	220406679	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:220406679G>A	uc002vmc.3	-	2	774	c.547C>T	c.(547-549)CAC>TAC	p.H183Y	CHPF_uc010zlh.1_Missense_Mutation_p.H21Y|CHPF_uc002vmd.3_Missense_Mutation_p.H183Y|TMEM198_uc002vme.2_5'Flank|TMEM198_uc002vmf.2_5'Flank	NM_024536	NP_078812	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	183	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding				0		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TCCAGCAGGTGGCGCAGCGCC	0.687											OREG0015229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	15					0	0	0.00185496	0	0
EPHA4	2043	broad.mit.edu	37	2	222436924	222436924	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:222436924C>T	uc002vmq.2	-	1	87	c.45G>A	c.(43-45)GGG>GGA	p.G15G	EPHA4_uc002vmr.2_Silent_p.G15G|EPHA4_uc010zlm.1_5'UTR|EPHA4_uc010zln.1_Silent_p.G15G|uc002vms.1_5'Flank	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	15						integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		CGTCGCAAATCCCGAAGAGAC	0.572													16	36					0	0	0.000566183	0	0
CUL3	8452	broad.mit.edu	37	2	225360606	225360606	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:225360606G>A	uc002vny.2	-	13	2169	c.1785C>T	c.(1783-1785)TCC>TCT	p.S595S	CUL3_uc010zls.1_Silent_p.S529S|CUL3_uc010fwy.1_Silent_p.S601S|CUL3_uc002vnz.1_Silent_p.S42S	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3	595					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCTGGAAAGTGGAAACTTGCA	0.328													59	47					0	0	0.000781405	0	0
SLC16A14	151473	broad.mit.edu	37	2	230902218	230902218	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:230902218C>T	uc002vqd.1	-	5	1774	c.1411G>A	c.(1411-1413)GAT>AAT	p.D471N	FBXO36_uc010fxi.1_Intron	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	471	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		AAGGAAAAATCATATTTTTGC	0.333													25	34					0	0	0.000878237	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911275	230911275	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:230911275C>T	uc002vqd.1	-	4	930	c.567G>A	c.(565-567)AGG>AGA	p.R189R	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Silent_p.R189R|SLC16A14_uc002vqf.2_Silent_p.R189R	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	189	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		ACATGGCATTCCTCCAGCCGT	0.592													49	70					0	0	0.000781405	0	0
SP100	6672	broad.mit.edu	37	2	231314285	231314285	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:231314285C>T	uc002vqt.2	+	7	737	c.596C>T	c.(595-597)CCA>CTA	p.P199L	SP100_uc002vqs.2_Missense_Mutation_p.P199L|SP100_uc002vqu.1_Missense_Mutation_p.P199L|SP100_uc010zmb.1_Missense_Mutation_p.P199L|SP100_uc002vqq.1_Missense_Mutation_p.P199L|SP100_uc002vqr.1_Missense_Mutation_p.P174L|SP100_uc010zmc.1_Missense_Mutation_p.P174L|SP100_uc002vqv.1_Missense_Mutation_p.P163L	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	199					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GGTACAACCCCACCTGAAAAT	0.473													21	36					0	0	0.000720815	0	0
NMUR1	10316	broad.mit.edu	37	2	232389986	232389986	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:232389986G>A	uc002vry.3	-	3	1159	c.1049C>T	c.(1048-1050)GCG>GTG	p.A350V		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	350	Helical; Name=7; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GGGGTTGGCCGCCGAGCCCAG	0.652													46	53					0	0	0.000781405	0	0
NMUR1	10316	broad.mit.edu	37	2	232393679	232393679	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:232393679C>T	uc002vry.3	-	2	163	c.53G>A	c.(52-54)GGG>GAG	p.G18E		NM_006056	NP_006047	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	18	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			lung(3)|central_nervous_system(1)|pancreas(1)	5		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		CCTTGCACCCCCTGGGTACAG	0.572													18	22					0	0	0.00152264	0	0
ECEL1	9427	broad.mit.edu	37	2	233346557	233346557	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:233346557G>A	uc002vsv.2	-	13	2004	c.1799C>T	c.(1798-1800)TCT>TTT	p.S600F	ECEL1_uc010fya.1_Missense_Mutation_p.S598F|ECEL1_uc010fyb.1_Missense_Mutation_p.S307F	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	600	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GTAGTTGAGAGACCTGGGCCC	0.682													14	31					0	0	0.000308642	0	0
NGEF	25791	broad.mit.edu	37	2	233839559	233839559	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:233839559C>T	uc002vts.2	-	2	290	c.42G>A	c.(40-42)AGG>AGA	p.R14R		NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	14	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TTGCTGATTTCCTCCGGGTCT	0.458													55	60					0	0	0.000781405	0	0
UGT1A9	54600	broad.mit.edu	37	2	234580754	234580754	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:234580754C>T	uc002vus.2	+	1	211	c.174C>T	c.(172-174)GTC>GTT	p.V58V	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Silent_p.V58V	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	58					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	TGGTTGTAGTCATGCCAGAGG	0.522													42	43					0	0	0.00170553	0	0
SH3BP4	23677	broad.mit.edu	37	2	235950772	235950772	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:235950772C>T	uc002vvp.2	+	4	1752	c.1359C>T	c.(1357-1359)GTC>GTT	p.V453V	SH3BP4_uc010fym.2_Silent_p.V453V|SH3BP4_uc002vvq.2_Silent_p.V453V	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	453					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		ACGTGGCTGTCGTGGCCCATG	0.572													5	20					0	0	0.00116845	0	0
AGAP1	116987	broad.mit.edu	37	2	236708057	236708057	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:236708057C>T	uc002vvs.2	+	8	1443	c.848C>T	c.(847-849)CCA>CTA	p.P283L	AGAP1_uc002vvt.2_Missense_Mutation_p.P283L	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	283					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding	p.P283S(1)		ovary(2)|skin(1)	3						TCCTCCGTTCCATCGACTCCC	0.517													33	25					0	0	0.000953801	0	0
GBX2	2637	broad.mit.edu	37	2	237074669	237074669	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:237074669G>A	uc002vvw.1	-	2	973	c.935C>T	c.(934-936)TCC>TTC	p.S312F	GBX2_uc010zng.1_3'UTR	NM_001485	NP_001476	P52951	GBX2_HUMAN	gastrulation brain homeo box 2	312						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		CCCTGTCTTGGAATTGGCATT	0.577													54	38					0	0	0.000781405	0	0
COL6A3	1293	broad.mit.edu	37	2	238275834	238275834	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:238275834C>T	uc002vwl.2	-	11	5281	c.4996G>A	c.(4996-4998)GTG>ATG	p.V1666M	COL6A3_uc002vwo.2_Missense_Mutation_p.V1460M|COL6A3_uc010znj.1_Missense_Mutation_p.V1059M	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1666	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACTGTGTCCACTATTTCAGAC	0.463													9	26					0	0	0.000673444	0	0
PER2	8864	broad.mit.edu	37	2	239186556	239186556	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:239186556G>A	uc002vyc.2	-	2	259	c.22C>T	c.(22-24)CCG>TCG	p.P8S	PER2_uc010znv.1_Missense_Mutation_p.P8S|PER2_uc010znw.1_Missense_Mutation_p.P8S|PER2_uc010fyx.1_Missense_Mutation_p.P8S	NM_022817	NP_073728	O15055	PER2_HUMAN	period 2	8					circadian rhythm|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|signal transducer activity			upper_aerodigestive_tract(1)|breast(1)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0423)|all_lung(227;0.114)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Lung NSC(271;0.223)|Hepatocellular(293;0.244)		Epithelial(121;6.84e-24)|OV - Ovarian serous cystadenocarcinoma(60;9.73e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;6.77e-05)|Lung(119;0.00941)|LUSC - Lung squamous cell carcinoma(224;0.0161)		GGGCTGGGCGGAAATTCCGCG	0.607													9	21					0	0	0.000442599	0	0
AQP12B	653437	broad.mit.edu	37	2	241621907	241621907	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:241621907C>T	uc010fzj.2	-	1	411	c.348G>A	c.(346-348)GCG>GCA	p.A116A	AQP12B_uc002vzt.2_RNA	NM_001102467	NP_001095937	A6NM10	AQ12B_HUMAN	aquaporin 12B	104	Helical; Name=3; (Potential).					integral to membrane	transporter activity				0		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		GCCCCTGTGCCGCCAGCTTCA	0.692													19	7					0	0	0.00121646	0	0
C2orf54	79919	broad.mit.edu	37	2	241826526	241826526	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr2:241826526G>A	uc002wae.3	-	5	1464	c.1305C>T	c.(1303-1305)ATC>ATT	p.I435I	C2orf54_uc002wac.2_Silent_p.I267I|C2orf54_uc002wad.2_Silent_p.I286I	NM_001085437	NP_001078906	Q08AI8	CB054_HUMAN	hypothetical protein LOC79919 isoform 1	435											0		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		TCTTCTGGAAGATGCTCTGCA	0.592													33	22					0	0	0.00058488	0	0
DEFB127	140850	broad.mit.edu	37	20	138224	138224	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:138224G>A	uc002wcy.1	+	1	39	c.39G>A	c.(37-39)CAG>CAA	p.Q13Q		NM_139074	NP_620713	Q9H1M4	DB127_HUMAN	defensin, beta 127 preproprotein	13					defense response to bacterium|innate immune response	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			TGCTGTTCCAGAAACCCACAG	0.473													52	30					0	0	0.000781405	0	0
C20orf54	113278	broad.mit.edu	37	20	746275	746275	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:746275G>A	uc002wed.3	-	2	483	c.144C>T	c.(142-144)ATC>ATT	p.I48I	C20orf54_uc002wee.2_Silent_p.I48I	NM_033409	NP_212134	Q9NQ40	RFT2_HUMAN	hypothetical protein LOC113278 precursor	48	Helical; (Potential).				sensory perception of sound	integral to plasma membrane	riboflavin transporter activity			ovary(2)	2						TGGCCAGCTGGATGACCACCG	0.647													11	10					0	0	0.000978159	0	0
TGM6	343641	broad.mit.edu	37	20	2375099	2375099	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:2375099G>A	uc002wfy.1	+	2	70	c.9G>A	c.(7-9)GGG>GGA	p.G3G	TGM6_uc010gal.1_Silent_p.G3G	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	3					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CCCACCCAGGGATCAGAGTCA	0.612													11	29					0	0	0.00136819	0	0
TGM6	343641	broad.mit.edu	37	20	2380989	2380989	+	Silent	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:2380989C>A	uc002wfy.1	+	7	949	c.888C>A	c.(886-888)TCC>TCA	p.S296S	TGM6_uc010gal.1_Silent_p.S296S	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	296					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GGGTCGTGTCCAACTTCAACT	0.617													5	60					8.12818e-05	0.000275641	0.00198382	1	0
C20orf194	25943	broad.mit.edu	37	20	3297413	3297413	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:3297413G>A	uc002wii.2	-	18	1547	c.1496C>T	c.(1495-1497)TCC>TTC	p.S499F	C20orf194_uc002wij.3_Missense_Mutation_p.S238F|C20orf194_uc002wik.2_Missense_Mutation_p.S173F	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	499											0						CAGGACTACGGAGCTGGTTTC	0.532													13	35					0	0	0.000566183	0	0
ADAM33	80332	broad.mit.edu	37	20	3655204	3655204	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:3655204C>T	uc002wit.2	-	6	634	c.547G>A	c.(547-549)GAT>AAT	p.D183N	ADAM33_uc002wir.1_Missense_Mutation_p.D183N|ADAM33_uc002wis.2_5'Flank|ADAM33_uc002wiu.2_Missense_Mutation_p.D183N|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Intron|ADAM33_uc010zqg.1_Missense_Mutation_p.D195N|ADAM33_uc010zqh.1_Missense_Mutation_p.D183N	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	183	Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						TTCCCAGGATCCCTGTGGCCA	0.607													70	34					0	0	0.000781405	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3678723	3678723	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:3678723C>T	uc002wja.2	-	8	1844	c.1844G>A	c.(1843-1845)GGG>GAG	p.G615E	SIGLEC1_uc002wiz.3_Missense_Mutation_p.G615E	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	615	Ig-like C2-type 6.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CCGTCCAGCCCCGGCCCCAGC	0.657													8	10					0	0	0.000157383	0	0
CENPB	1059	broad.mit.edu	37	20	3765728	3765728	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:3765728G>A	uc002wjk.2	-	1	1610	c.1403C>T	c.(1402-1404)TCG>TTG	p.S468L	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	468					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						CAAGCCCTCCGAGGAGCTCTC	0.448													15	19					0	0	0.000958276	0	0
CENPB	1059	broad.mit.edu	37	20	3765730	3765730	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:3765730G>A	uc002wjk.2	-	1	1608	c.1401C>T	c.(1399-1401)TCC>TCT	p.S467S	CDC25B_uc010zqk.1_5'Flank|CDC25B_uc010zql.1_5'Flank|CDC25B_uc010zqm.1_5'Flank	NM_001810	NP_001801	P07199	CENPB_HUMAN	centromere protein B	467					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding				0						AGCCCTCCGAGGAGCTCTCCT	0.443													16	20					0	0	0.00121646	0	0
MAVS	57506	broad.mit.edu	37	20	3844958	3844958	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:3844958C>T	uc002wjw.3	+	6	850	c.681C>T	c.(679-681)TTC>TTT	p.F227F	MAVS_uc002wjx.3_Silent_p.F86F|MAVS_uc002wjy.3_5'UTR	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter	227	Cytoplasmic (Probable).				activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CTGTCTCCTTCCAGCCCCTGG	0.607													36	88					0	0	0.00128727	0	0
C20orf30	29058	broad.mit.edu	37	20	5081503	5081503	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:5081503G>A	uc002wll.2	-	5	763	c.297C>T	c.(295-297)ATC>ATT	p.I99I	C20orf30_uc010gbi.2_Intron|C20orf30_uc002wlk.2_Silent_p.I162I|C20orf30_uc002wlm.2_Silent_p.I99I|C20orf30_uc002wln.2_Silent_p.I99I|C20orf30_uc002wlo.2_RNA	NM_001009924	NP_001009924	Q96A57	CT030_HUMAN	hypothetical protein LOC29058 isoform 2	99	Helical; (Potential).					integral to membrane					0						CATAGTAAGCGATGCGCAGGT	0.537											OREG0025754	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	88					0	0	0.00198382	0	0
CDS2	8760	broad.mit.edu	37	20	5154251	5154251	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:5154251C>T	uc002wls.2	+	2	397	c.140C>T	c.(139-141)TCT>TTT	p.S47F	CDS2_uc002wlr.1_5'UTR|CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Intron|CDS2_uc010zqu.1_Intron|CDS2_uc002wlv.2_5'Flank	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	47					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						CTGCCAGTCTCTGCAGATGAT	0.532													114	75					0	0	0.000781405	0	0
PROKR2	128674	broad.mit.edu	37	20	5282938	5282938	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:5282938G>A	uc010zqw.1	-	2	903	c.903C>T	c.(901-903)TTC>TTT	p.F301F	PROKR2_uc010zqx.1_Silent_p.F301F|PROKR2_uc010zqy.1_Silent_p.F301F	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	301	Extracellular (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						ACACAGTGGGGAAGAAGTCAC	0.552										HNSCC(71;0.22)			44	18					0	0	0.00170553	0	0
XRN2	22803	broad.mit.edu	37	20	21311265	21311265	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:21311265C>T	uc002wsf.1	+	6	593	c.498C>T	c.(496-498)TTC>TTT	p.F166F	XRN2_uc002wsg.1_Silent_p.F90F|XRN2_uc010zsk.1_Silent_p.F112F	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	166					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						GAACTGAATTCATGGACAATC	0.328													11	48					0	0	0.000673444	0	0
FRG1B	284802	broad.mit.edu	37	20	29625891	29625891	+	Silent	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:29625891C>G	uc010ztl.1	+	2	77	c.45C>G	c.(43-45)GGC>GGG	p.G15G	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TGAAATCTGGCTATGGAAAAT	0.343													4	118					0	0	0.00198382	0	0
FRG1B	284802	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:29628251A>G	uc010ztl.1	+	3	195	c.163A>G	c.(163-165)AAT>GAT	p.N55D	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.N7D					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTTGGCCTCAAATAGCTGCTT	0.358													3	75					0	0	6.4e-05	0	0
C20orf112	140688	broad.mit.edu	37	20	31044121	31044121	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:31044121C>A	uc002wxu.3	-	3	344	c.187G>T	c.(187-189)GAC>TAC	p.D63Y	C20orf112_uc010gec.2_5'UTR	NM_080616	NP_542183	Q96MY1	CT112_HUMAN	hypothetical protein LOC140688	63											0						AAGGCAGGGTCGCCCTGCGTG	0.642													20	50					9.7654e-05	0.000331023	0.000958276	1	0
BPIL3	128859	broad.mit.edu	37	20	31626730	31626731	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:31626730_31626731CC>AA	uc010zuc.1	+	9	862_863	c.862_863CC>AA	c.(862-864)CCA>AAA	p.P288K	BPIL3_uc010zud.1_Missense_Mutation_p.P227K	NM_174897	NP_777557	Q8NFQ5	BPIL3_HUMAN	bactericidal/permeability-increasing	288						extracellular region	lipid binding			ovary(1)|pancreas(1)	2						TGAGCTGCCCCCACAAACCACC	0.535													14	581					0	0	6.4e-05	0	0
C20orf186	149954	broad.mit.edu	37	20	31682955	31682956	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:31682955_31682956CC>AA	uc010zue.1	+	10	1409_1410	c.1394_1395CC>AA	c.(1393-1395)CCC>CAA	p.P465Q		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	465						cytoplasm|extracellular region	lipid binding				0						GCCCTGATCCCCAAGGTATGTA	0.53													15	581					0	0	6.4e-05	0	0
ZNF341	84905	broad.mit.edu	37	20	32349802	32349802	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:32349802C>T	uc002wzy.2	+	8	1183	c.1163C>T	c.(1162-1164)TCT>TTT	p.S388F	ZNF341_uc002wzx.2_Missense_Mutation_p.S381F|ZNF341_uc010geq.2_Missense_Mutation_p.S298F|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	388					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						TCTCGAAACTCTGTGACCGTA	0.572													59	153					0	0	0.000781405	0	0
C20orf117	140710	broad.mit.edu	37	20	35422902	35422902	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:35422902G>A	uc002xgd.1	-	14	3196	c.2869C>T	c.(2869-2871)CCT>TCT	p.P957S	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	957											0		Myeloproliferative disorder(115;0.00874)				CCAAAGGCAGGGTTGTTAGGC	0.557													50	157					0	0	0.000781405	0	0
C20orf117	140710	broad.mit.edu	37	20	35444643	35444643	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:35444643T>G	uc002xgd.1	-	5	815	c.488A>C	c.(487-489)AAG>ACG	p.K163T	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	163											0		Myeloproliferative disorder(115;0.00874)				CTTAGTGAGCTTCTTGCACAT	0.567													89	66					0	0	0.000781405	0	0
C20orf118	140711	broad.mit.edu	37	20	35507473	35507473	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:35507473C>T	uc002xgg.1	+	3	227	c.219C>T	c.(217-219)ACC>ACT	p.T73T		NM_080628	NP_542195	A0PJX2	CT118_HUMAN	hypothetical protein LOC140711	73											0		Myeloproliferative disorder(115;0.00874)				CAAGAGTCACCGGCCATCCCT	0.632													37	131					0	0	0.0025221	0	0
CTNNBL1	56259	broad.mit.edu	37	20	36468529	36468529	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:36468529C>T	uc010zvw.1	+	13	1330	c.1239C>T	c.(1237-1239)TCC>TCT	p.S413S	CTNNBL1_uc002xhh.2_Silent_p.S226S|CTNNBL1_uc002xhi.2_RNA|CTNNBL1_uc002xhj.2_Silent_p.S161S	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	413					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				TCCTGGCTTCCCTCCTGCGGA	0.502													56	41					0	0	0.000781405	0	0
KIAA0406	9675	broad.mit.edu	37	20	36624820	36624820	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:36624820G>A	uc002xhl.2	-	8	3252	c.3043C>T	c.(3043-3045)CTC>TTC	p.L1015F	KIAA0406_uc002xhm.2_Missense_Mutation_p.L1015F	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	1015							binding				0		Myeloproliferative disorder(115;0.00874)				TTGACACTGAGGTAAATCAAG	0.453													31	87					0	0	0.00170553	0	0
KIAA0406	9675	broad.mit.edu	37	20	36641847	36641847	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:36641847G>A	uc002xhl.2	-	3	581	c.372C>T	c.(370-372)ATC>ATT	p.I124I	KIAA0406_uc002xhm.2_Silent_p.I124I	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	124							binding				0		Myeloproliferative disorder(115;0.00874)				TAAGTCCCTGGATCACAGCCA	0.463													72	120					0	0	0.000781405	0	0
SLC32A1	140679	broad.mit.edu	37	20	37353485	37353485	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:37353485G>A	uc002xjc.2	+	1	381	c.118G>A	c.(118-120)GAG>AAG	p.E40K		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	40	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	CACGGATGAGGAGGCGGTGGG	0.637													12	38					0	0	0.00136819	0	0
TOP1	7150	broad.mit.edu	37	20	39741563	39741563	+	Nonsense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:39741563A>T	uc002xjl.2	+	14	1696	c.1450A>T	c.(1450-1452)AAG>TAG	p.K484*	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	484					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	CTTCATCGACAAGGTGAGAGC	0.458			T	NUP98	AML*								32	24					0	0	0.00283554	0	0
CHD6	84181	broad.mit.edu	37	20	40042110	40042110	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:40042110G>A	uc002xka.1	-	35	7163	c.6985C>T	c.(6985-6987)CCT>TCT	p.P2329S	CHD6_uc002xjz.1_5'UTR	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2329					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GGCCCCTCAGGGTGTGTGGTG	0.547													13	12					0	0	0.00185496	0	0
L3MBTL	26013	broad.mit.edu	37	20	42162941	42162942	+	Silent	DNP	CC	TT	TT	rs143612275		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:42162941_42162942CC>TT	uc010zwh.1	+	15	1597_1598	c.1551_1552CC>TT	c.(1549-1554)TTCCTG>TTTTTG	p.517_518FL>FL	L3MBTL_uc002xkl.2_Silent_p.449_450FL>FL|L3MBTL_uc002xkm.2_Silent_p.449_450FL>FL|L3MBTL_uc010ggl.2_Silent_p.449_450FL>FL|L3MBTL_uc002xkn.1_Silent_p.208_209FL>FL|L3MBTL_uc002xko.2_Silent_p.101_102FL>FL	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	449_450	MBT 3.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CTCACAGCTTCCTGGTCAATAT	0.624													26	69					0	0	6.4e-05	0	0
SGK2	10110	broad.mit.edu	37	20	42199686	42199686	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:42199686C>T	uc002xkv.2	+	7	895	c.676C>T	c.(676-678)CTC>TTC	p.L226F	SGK2_uc002xkt.2_RNA|SGK2_uc002xkr.2_Missense_Mutation_p.L166F|SGK2_uc010ggm.2_Missense_Mutation_p.L166F|SGK2_uc002xks.2_Missense_Mutation_p.L165F|SGK2_uc002xku.2_Missense_Mutation_p.L166F	NM_016276	NP_057360	Q9HBY8	SGK2_HUMAN	serum/glucocorticoid regulated kinase 2 isoform	226	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|potassium channel regulator activity|protein serine/threonine kinase activity|sodium channel regulator activity			lung(3)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	6		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			AGAGAACATTCTCTTGGACTG	0.378													59	91					0	0	0.000781405	0	0
TP53TG5	27296	broad.mit.edu	37	20	44003783	44003783	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:44003783C>T	uc002xny.2	-	4	745	c.664G>A	c.(664-666)GCG>ACG	p.A222T	SYS1_uc002xnw.1_3'UTR|SYS1-DBNDD2_uc002xnx.2_Intron	NM_014477	NP_055292	Q9Y2B4	T53G5_HUMAN	TP53-target gene 5 protein	222					intracellular signal transduction|negative regulation of cell growth	cytoplasm|nucleus				central_nervous_system(1)	1						ACCCTGGGCGCCGGGAGGTGG	0.602													48	38					0	0	0.000781405	0	0
WFDC10B	280664	broad.mit.edu	37	20	44313538	44313538	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:44313538G>A	uc002xpb.2	-	4	384	c.153C>T	c.(151-153)TTC>TTT	p.F51F	WFDC10B_uc002xpc.2_Silent_p.F67F	NM_172006	NP_742003	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B isoform a	51	WAP.					extracellular region	peptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CACACTTTTGGAAATATGAAC	0.463													82	54					0	0	0.000781405	0	0
CDH22	64405	broad.mit.edu	37	20	44806775	44806775	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:44806775G>A	uc002xrm.2	-	10	2126	c.1725C>T	c.(1723-1725)TTC>TTT	p.F575F	CDH22_uc010ghk.1_Silent_p.F575F	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	575	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				TGGGCAGGAAGAACACGTCCT	0.647													13	29					0	0	0.00136819	0	0
ZNF334	55713	broad.mit.edu	37	20	45130524	45130524	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:45130524C>T	uc002xsc.2	-	5	1638	c.1454G>A	c.(1453-1455)GGA>GAA	p.G485E	ZNF334_uc002xsa.2_Missense_Mutation_p.G508E|ZNF334_uc002xsb.2_Missense_Mutation_p.G447E|ZNF334_uc002xsd.2_Missense_Mutation_p.G447E|ZNF334_uc010ghl.2_Missense_Mutation_p.G484E	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	485					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				ATGTTTCTCTCCTGTGTGTGT	0.363													41	158					0	0	0.00170553	0	0
ZNF334	55713	broad.mit.edu	37	20	45130722	45130722	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:45130722G>A	uc002xsc.2	-	5	1440	c.1256C>T	c.(1255-1257)GCC>GTC	p.A419V	ZNF334_uc002xsa.2_Missense_Mutation_p.A442V|ZNF334_uc002xsb.2_Missense_Mutation_p.A381V|ZNF334_uc002xsd.2_Missense_Mutation_p.A381V|ZNF334_uc010ghl.2_Missense_Mutation_p.A418V	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	419	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				CACATTGAGGGCAGATTGACA	0.423													57	128					0	0	0.000781405	0	0
FAM65C	140876	broad.mit.edu	37	20	49219013	49219013	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:49219013C>T	uc002xvm.2	-	13	1561	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	FAM65C_uc010zyt.1_Missense_Mutation_p.E419K|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.E415K	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	415										ovary(2)	2						GTGCTGGTCTCCGTGTCTCGG	0.642													72	53					0	0	0.000781405	0	0
C20orf107	388799	broad.mit.edu	37	20	55111389	55111389	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:55111389G>A	uc010zzh.1	+	2	491	c.411G>A	c.(409-411)ATG>ATA	p.M137I	C20orf107_uc002xxz.2_Missense_Mutation_p.M137I	NM_001013646	NP_001013668	Q5JX69	CT107_HUMAN	hypothetical protein LOC388799 precursor	137	Cytoplasmic (Potential).					integral to membrane					0			Colorectal(105;0.202)			AAGGTGCCATGGCAACAGGCA	0.423													68	57					0	0	0.000781405	0	0
PMEPA1	56937	broad.mit.edu	37	20	56234731	56234731	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:56234731G>A	uc002xyq.2	-	2	525	c.132C>T	c.(130-132)ATC>ATT	p.I44I	PMEPA1_uc002xyr.2_5'UTR|PMEPA1_uc002xys.2_Silent_p.I9I|PMEPA1_uc002xyt.2_5'UTR	NM_020182	NP_064567	Q969W9	PMEPA_HUMAN	transmembrane prostate androgen-induced protein	44	Helical; (Potential).				androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			pancreas(1)	1						CGATGATGATGATCTGAACAA	0.493													5	8					0	0	0.000602214	0	0
C20orf85	128602	broad.mit.edu	37	20	56735719	56735719	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:56735719C>T	uc002xyv.2	+	4	293	c.255C>T	c.(253-255)GTC>GTT	p.V85V		NM_178456	NP_848551	Q9H1P6	CT085_HUMAN	hypothetical protein LOC128602	85										ovary(1)	1	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			CATTCCAGGTCTTTCCATCCC	0.567													13	34					0	0	0.00185496	0	0
ZNF831	128611	broad.mit.edu	37	20	57829282	57829283	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:57829282_57829283GG>AA	uc002yan.2	+	5	4518_4519	c.4518_4519GG>AA	c.(4516-4521)CAGGAA>CAAAAA	p.E1507K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1507						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					ACATAGCCCAGGAAATTCACAG	0.515													39	58					0	0	6.4e-05	0	0
CDH26	60437	broad.mit.edu	37	20	58567442	58567442	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:58567442G>A	uc002ybe.2	+	10	1593	c.1293G>A	c.(1291-1293)CTG>CTA	p.L431L	CDH26_uc002ybf.1_Silent_p.L11L|CDH26_uc010zzy.1_RNA|CDH26_uc002ybg.2_5'Flank	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	431	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GATATGAACTGGTTCATGACC	0.363													18	39					0	0	0.000566183	0	0
LSM14B	149986	broad.mit.edu	37	20	60701392	60701392	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:60701392C>T	uc010gjy.1	+	3	530	c.324C>T	c.(322-324)TTC>TTT	p.F108F	LSM14B_uc002ybt.2_Silent_p.F108F|LSM14B_uc010gjx.1_Silent_p.F134F|LSM14B_uc002ybv.2_Silent_p.F108F|LSM14B_uc010gjz.1_5'UTR|LSM14B_uc010zzz.1_5'UTR	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	108					multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CCTCGCCCTTCCAGCCGCACG	0.672													24	46					0	0	0.001512	0	0
OSBPL2	9885	broad.mit.edu	37	20	60838688	60838688	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:60838688C>T	uc002yck.1	+	4	401	c.199C>T	c.(199-201)CCC>TCC	p.P67S	OSBPL2_uc002ycl.1_Missense_Mutation_p.P55S|OSBPL2_uc011aah.1_5'UTR	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	67					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GCTGCCGGCTCCCATGTTCAG	0.577													34	83					0	0	0.000953801	0	0
LAMA5	3911	broad.mit.edu	37	20	60887273	60887273	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:60887273G>A	uc002ycq.2	-	69	9527	c.9460C>T	c.(9460-9462)CAC>TAC	p.H3154Y		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3154	Laminin G-like 3.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGCGCTGTGGAAGCCGAAG	0.682													23	23					0	0	0.000720815	0	0
DIDO1	11083	broad.mit.edu	37	20	61511312	61511312	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:61511312G>A	uc002ydr.1	-	16	6260	c.5996C>T	c.(5995-5997)TCT>TTT	p.S1999F	DIDO1_uc002yds.1_Missense_Mutation_p.S1999F	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1999	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					ATTTTTTTCAGAAAAGGGTGC	0.602													151	108					0	0	0.000781405	0	0
BIRC7	79444	broad.mit.edu	37	20	61870912	61870912	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:61870912C>T	uc002yej.2	+	6	1025	c.852C>T	c.(850-852)ATC>ATT	p.I284I	BIRC7_uc010gkc.1_3'UTR|BIRC7_uc002yei.2_Silent_p.I266I	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	284	RING-type.				activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					TGTGCCCCATCTGCAGAGCCC	0.716													20	21					0	0	0.00188189	0	0
COL20A1	57642	broad.mit.edu	37	20	61939414	61939414	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:61939414C>T	uc011aau.1	+	7	847	c.747C>T	c.(745-747)CTC>CTT	p.L249L	COL20A1_uc011aav.1_Silent_p.L70L	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	249	VWFA.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					TGCGCCGCCTCCGCTACAAGG	0.657													23	69					0	0	0.000586117	0	0
RTEL1	51750	broad.mit.edu	37	20	62316898	62316898	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:62316898C>T	uc002yfu.1	+	15	1557	c.1214C>T	c.(1213-1215)TCC>TTC	p.S405F	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.S405F|RTEL1_uc011abd.1_Missense_Mutation_p.S429F|RTEL1_uc011abe.1_Missense_Mutation_p.S182F|RTEL1_uc002yfw.2_RNA	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	405					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GTGGACCCCTCCGAGGGCAGC	0.632													20	39					0	0	0.00278032	0	0
ZBTB46	140685	broad.mit.edu	37	20	62407158	62407158	+	Silent	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:62407158G>C	uc002ygv.1	-	3	1296	c.1095C>G	c.(1093-1095)ACC>ACG	p.T365T	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					TGGCCACCGCGGTGGCCTGAT	0.652													45	86					0	0	0.000781405	0	0
RGS19	10287	broad.mit.edu	37	20	62705292	62705292	+	Silent	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:62705292G>T	uc002yhy.2	-	6	835	c.568C>A	c.(568-570)CGG>AGG	p.R190R	RGS19_uc002yhz.2_Silent_p.R168R|RGS19_uc002yia.2_Silent_p.R190R|RGS19_uc002yib.2_Silent_p.R190R	NM_005873	NP_005864	P49795	RGS19_HUMAN	G protein signalling regulator 19	190	RGS.				autophagy|G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			skin(1)	1	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					TAGGAGTCCCGGTGCATGAGC	0.662													6	132					1.12685e-05	3.82939e-05	0.000274275	1	0
OPRL1	4987	broad.mit.edu	37	20	62729457	62729457	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:62729457C>T	uc002yic.2	+	4	938	c.536C>T	c.(535-537)TCT>TTT	p.S179F	OPRL1_uc002yid.2_Missense_Mutation_p.S179F|OPRL1_uc002yif.3_Missense_Mutation_p.S174F	NM_182647	NP_872588	P41146	OPRX_HUMAN	opiate receptor-like 1	179	Helical; Name=4; (Potential).				elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					GCCCTGGCCTCTGTTGTCGGT	0.647													20	68					0	0	0.00152264	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737993	62737993	+	Silent	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:62737993C>G	uc011abt.1	-	1	192	c.192G>C	c.(190-192)ACG>ACC	p.T64T		NM_005286	NP_005277	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	64	Helical; Name=1; (Potential).					plasma membrane	opioid receptor activity|protein binding			large_intestine(1)	1	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					GGATGACGGCCGTGTTGCCAG	0.612													25	31					0	0	0.00278032	0	0
MYT1	4661	broad.mit.edu	37	20	62848472	62848472	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:62848472C>T	uc002yii.2	+	11	2048	c.1684C>T	c.(1684-1686)CCC>TCC	p.P562S	MYT1_uc002yih.2_Missense_Mutation_p.P264S|MYT1_uc002yij.2_Missense_Mutation_p.P194S	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	562					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GAGCTACCGGCCCAACGTGGC	0.597													24	81					0	0	0.000586117	0	0
LIPI	149998	broad.mit.edu	37	21	15517024	15517024	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:15517024G>A	uc002yjm.2	-	9	1288	c.1278C>T	c.(1276-1278)TTC>TTT	p.F426F		NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	405					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TTGAGCTCTGGAAATATGTCA	0.313													50	77					0	0	0.000781405	0	0
GRIK1	2897	broad.mit.edu	37	21	30949459	30949459	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:30949459C>A	uc002yno.1	-	14	2419	c.1955G>T	c.(1954-1956)GGA>GTA	p.G652V	GRIK1_uc002ynn.2_Missense_Mutation_p.G637V|GRIK1_uc011acs.1_Missense_Mutation_p.G652V|GRIK1_uc011act.1_Missense_Mutation_p.G513V	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	652	Cytoplasmic (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCATATCCCTCCAACTATTCT	0.458													24	72					7.92952e-12	2.71068e-11	0.000586117	1	0
KRTAP19-2	337969	broad.mit.edu	37	21	31859583	31859583	+	Missense_Mutation	SNP	C	T	T	rs137856992	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:31859583C>T	uc011acy.1	-	1	85	c.85G>A	c.(85-87)GGC>AGC	p.G29S		NM_181608	NP_853639	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	29						intermediate filament					0						CCTCTGTGGCCACAACCATAT	0.532													80	122					0	0	0.000781405	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253821	32253821	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:32253821C>T	uc002yov.2	-	1	54	c.23G>A	c.(22-24)AGA>AAA	p.R8K		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	8						keratin filament	structural molecule activity			pancreas(1)	1						AGAGCAATTTCTTGTGGAGCA	0.532													52	78					0	0	0.000781405	0	0
TIAM1	7074	broad.mit.edu	37	21	32582379	32582379	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:32582379G>A	uc002yow.1	-	12	2842	c.2370C>T	c.(2368-2370)ACC>ACT	p.T790T	TIAM1_uc011adk.1_Silent_p.T790T|TIAM1_uc011adl.1_Silent_p.T765T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	790	RBD.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCAGCTCCAGGGTGTCCCGTG	0.532													28	24					0	0	0.001512	0	0
SYNJ1	8867	broad.mit.edu	37	21	34018874	34018874	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:34018874G>A	uc002yqh.2	-	24	3193	c.3193C>T	c.(3193-3195)CTT>TTT	p.L1065F	SYNJ1_uc011ads.1_Missense_Mutation_p.L1021F|SYNJ1_uc002yqf.2_Missense_Mutation_p.L1026F|SYNJ1_uc002yqg.2_Missense_Mutation_p.L1021F|SYNJ1_uc002yqi.2_Missense_Mutation_p.L1065F	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	1026	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						TGCTGAGGAAGAAGTTCCTCC	0.468													30	49					0	0	0.001512	0	0
IFNAR2	3455	broad.mit.edu	37	21	34635104	34635104	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:34635104C>T	uc002yrd.2	+	9	1175	c.847C>T	c.(847-849)CAT>TAT	p.H283Y	IFNAR2_uc002yre.2_Missense_Mutation_p.H283Y|IFNAR2_uc002yrf.2_Missense_Mutation_p.S239L|IL10RB_uc002yrh.1_Intron|IL10RB_uc002yri.1_Intron	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	283	Cytoplasmic (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TAAGAATTTTCATAACTTTTT	0.343													36	50					0	0	0.00148497	0	0
IFNAR2	3455	broad.mit.edu	37	21	34635633	34635633	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:34635633C>A	uc002yrd.2	+	9	1704	c.1376C>A	c.(1375-1377)CCA>CAA	p.P459Q	IFNAR2_uc002yre.2_Missense_Mutation_p.P459Q|IFNAR2_uc002yrf.2_3'UTR|IL10RB_uc002yrh.1_Intron|IL10RB_uc002yri.1_Intron	NM_207585	NP_997468	P48551	INAR2_HUMAN	interferon alpha/beta receptor 2 isoform a	459	Cytoplasmic (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to interferon-alpha|response to virus|type I interferon-mediated signaling pathway	extracellular region|extracellular space|integral to plasma membrane	protein kinase binding|type I interferon binding|type I interferon receptor activity				0					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	ATGGTTGACCCAGAGGATCCT	0.512													9	300					3.86212e-05	0.000131081	0.000673444	1	0
GART	2618	broad.mit.edu	37	21	34897104	34897104	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:34897104G>A	uc002yrx.2	-	11	1405	c.1270C>T	c.(1270-1272)CGT>TGT	p.R424C	GART_uc002yrz.2_Missense_Mutation_p.R424C|GART_uc010gmd.2_Missense_Mutation_p.R86C|GART_uc002yry.2_Missense_Mutation_p.R424C|GART_uc002ysa.2_Missense_Mutation_p.R424C	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	424					'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	GCTATGGCACGAAAGCCGACG	0.448													53	31					0	0	0.000781405	0	0
SLC5A3	6526	broad.mit.edu	37	21	35468710	35468711	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:35468710_35468711CG>AT	uc002yto.2	+	2	1725_1726	c.1213_1214CG>AT	c.(1213-1215)CGG>ATG	p.R405M	MRPS6_uc002ytp.2_Intron	NM_006933	NP_008864	P53794	SC5A3_HUMAN	solute carrier family 5 (inositol transporters),	405	Cytoplasmic (Potential).					integral to plasma membrane	myo-inositol:sodium symporter activity			ovary(2)	2						CGCAAGCTCCCGGGAGTTAATG	0.475													12	550					0	0	6.4e-05	0	0
DOPEY2	9980	broad.mit.edu	37	21	37660349	37660349	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:37660349C>T	uc002yvg.2	+	33	6277	c.6198C>T	c.(6196-6198)TCC>TCT	p.S2066S	DOPEY2_uc011aeb.1_Silent_p.S2015S	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	2066					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GACAGACATCCATAGTTGCTG	0.378													57	74					0	0	0.000781405	0	0
DSCR4	10281	broad.mit.edu	37	21	39427000	39427000	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:39427000C>T	uc002ywp.2	-	3	411	c.306G>A	c.(304-306)AAG>AAA	p.K102K		NM_005867	NP_005858	P56555	DSCR4_HUMAN	Down syndrome critical region protein 4	102										ovary(1)	1						CATCTGATTTCTTGTGGAGCC	0.363													50	56					0	0	0.000781405	0	0
SH3BGR	6450	broad.mit.edu	37	21	40823881	40823881	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:40823881G>A	uc002yya.2	+	1	102	c.48G>A	c.(46-48)CGG>CGA	p.R16R	SH3BGR_uc002yxz.2_Intron	NM_007341	NP_031367	P55822	SH3BG_HUMAN	SH3-binding domain and glutamic acid-rich	16					protein complex assembly	cytosol	SH3 domain binding|SH3/SH2 adaptor activity				0		all_cancers(19;1.16e-23)|all_epithelial(19;1.22e-20)|Prostate(19;2.55e-06)|Breast(209;0.0133)		STAD - Stomach adenocarcinoma(101;0.00151)		AGTTGGAGCGGGACTGCCGGA	0.592													26	38					0	0	0.000586117	0	0
DSCAM	1826	broad.mit.edu	37	21	41684257	41684257	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:41684257G>A	uc002yyq.1	-	9	2265	c.1813C>T	c.(1813-1815)CCA>TCA	p.P605S	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	605	Extracellular (Potential).|Ig-like C2-type 7.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GAGAATCTTGGAAACTCAAAG	0.468													13	18					0	0	0.00185496	0	0
UBASH3A	53347	broad.mit.edu	37	21	43852251	43852252	+	Missense_Mutation	DNP	GG	AA	AA	rs151042130		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:43852251_43852252GG>AA	uc002zbe.2	+	9	1246_1247	c.1210_1211GG>AA	c.(1210-1212)GGG>AAG	p.G404K	UBASH3A_uc002zbf.2_Missense_Mutation_p.G366K|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.G366K	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	404	Phosphatase-like.					cytosol|nucleus				ovary(3)	3						GGTTCGCCACGGGGAGAGAGTG	0.569													5	15					0	0	6.4e-05	0	0
PDE9A	5152	broad.mit.edu	37	21	44188352	44188352	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:44188352G>A	uc002zbm.2	+	16	1474	c.1411G>A	c.(1411-1413)GAA>AAA	p.E471K	PDE9A_uc002zbn.2_Missense_Mutation_p.E344K|PDE9A_uc002zbo.2_Missense_Mutation_p.E418K|PDE9A_uc002zbp.2_Missense_Mutation_p.E264K|PDE9A_uc002zbq.2_Missense_Mutation_p.E369K|PDE9A_uc002zbs.2_Missense_Mutation_p.E264K|PDE9A_uc002zbr.2_Missense_Mutation_p.E264K|PDE9A_uc002zbt.2_Missense_Mutation_p.E343K|PDE9A_uc002zbu.2_Missense_Mutation_p.E337K|PDE9A_uc002zbv.2_Missense_Mutation_p.E311K|PDE9A_uc002zbw.2_Missense_Mutation_p.E254K|PDE9A_uc002zbx.2_Missense_Mutation_p.E411K|PDE9A_uc002zby.2_Missense_Mutation_p.E254K|PDE9A_uc002zbz.2_Missense_Mutation_p.E363K|PDE9A_uc002zca.2_Missense_Mutation_p.E430K|PDE9A_uc002zcb.2_Missense_Mutation_p.E445K|PDE9A_uc002zcc.2_Missense_Mutation_p.E370K|PDE9A_uc002zcd.2_Missense_Mutation_p.E385K|PDE9A_uc002zce.2_Missense_Mutation_p.E404K|PDE9A_uc002zcf.2_Missense_Mutation_p.E264K|PDE9A_uc002zcg.2_Missense_Mutation_p.E264K|PDE9A_uc002zch.2_Missense_Mutation_p.E254K	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	471	Catalytic (By similarity).				platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						CCGTCCAATGGAAGTCGCAGA	0.433													44	33					0	0	0.000781405	0	0
SIK1	150094	broad.mit.edu	37	21	44839251	44839251	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:44839251G>A	uc002zdf.2	-	10	1354	c.1227C>T	c.(1225-1227)CTC>CTT	p.L409L		NM_173354	NP_775490	P57059	SIK1_HUMAN	salt-inducible kinase 1	409					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(2)|testis(2)|ovary(1)|central_nervous_system(1)|skin(1)	7						GCGAGCTCTGGAGCTCACAGT	0.677													13	14					0	0	0.00136819	0	0
TRPM2	7226	broad.mit.edu	37	21	45786723	45786723	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:45786723G>A	uc002zet.1	+	5	723	c.510G>A	c.(508-510)TTG>TTA	p.L170L	TRPM2_uc002zeu.1_Silent_p.L170L|TRPM2_uc002zew.1_Silent_p.L170L|TRPM2_uc010gpt.1_Silent_p.L170L|TRPM2_uc002zex.1_5'Flank	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	170	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCAATCTCTTGATCTCGGTGA	0.602													33	44					0	0	0.000692331	0	0
TRPM2	7226	broad.mit.edu	37	21	45821720	45821720	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:45821720C>T	uc002zet.1	+	17	2691	c.2478C>T	c.(2476-2478)TCC>TCT	p.S826S	TRPM2_uc002zeu.1_Silent_p.S826S|TRPM2_uc002zew.1_Silent_p.S826S|TRPM2_uc010gpt.1_Silent_p.S826S|TRPM2_uc002zex.1_Silent_p.S612S|TRPM2_uc002zey.1_Silent_p.S339S	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	826	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTGTGCCCTCCTGGTGCGAGT	0.637													131	180					0	0	0.000781405	0	0
TRPM2	7226	broad.mit.edu	37	21	45837819	45837819	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:45837819C>T	uc002zet.1	+	22	3369	c.3156C>T	c.(3154-3156)TTC>TTT	p.F1052F	TRPM2_uc002zeu.1_Silent_p.F1052F|TRPM2_uc002zew.1_Silent_p.F1052F|TRPM2_uc010gpt.1_Silent_p.F1052F|TRPM2_uc002zex.1_Silent_p.F838F|TRPM2_uc002zey.1_Silent_p.F565F|uc011afe.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1052	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GCTACACCTTCCAGCAGGTGC	0.502													23	40					0	0	0.000878237	0	0
SLC19A1	6573	broad.mit.edu	37	21	46951972	46951972	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:46951972G>A	uc002zhl.1	-	3	399	c.280C>T	c.(280-282)CCG>TCG	p.P94S	SLC19A1_uc010gpy.1_Missense_Mutation_p.P94S|SLC19A1_uc011aft.1_Missense_Mutation_p.P54S|SLC19A1_uc002zhm.1_Missense_Mutation_p.P94S|SLC19A1_uc010gpz.1_5'UTR	NM_194255	NP_919231	P41440	S19A1_HUMAN	solute carrier family 19 member 1	94	Cytoplasmic (Probable).				folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity				0				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		AGCAGCACCGGCGTGTAGCGC	0.647													16	39					0	0	0.00074312	0	0
MCM3AP	8888	broad.mit.edu	37	21	47679005	47679005	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:47679005C>A	uc002zir.1	-	16	3618	c.3582G>T	c.(3580-3582)AAG>AAT	p.K1194N	MCM3AP_uc002zip.1_5'UTR|MCM3AP_uc002ziq.1_Missense_Mutation_p.K121N	NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	1194					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					CTACTGCATTCCTAGAAACAG	0.483													56	60					9.39563e-20	3.22965e-19	0.000781405	1	0
DIP2A	23181	broad.mit.edu	37	21	47969774	47969774	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr21:47969774C>T	uc002zjo.2	+	22	2796	c.2613C>T	c.(2611-2613)TTC>TTT	p.F871F	DIP2A_uc011afy.1_Silent_p.F807F|DIP2A_uc011afz.1_Silent_p.F867F|DIP2A_uc002zjn.2_Silent_p.F871F	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	871					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		AGGACAGCTTCCAGTGGATGA	0.647													63	60					0	0	0.000781405	0	0
POTEH	23784	broad.mit.edu	37	22	16266988	16266988	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:16266988C>T	uc010gqp.2	-	9	1513	c.1461G>A	c.(1459-1461)AGG>AGA	p.R487R	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_Silent_p.R206R|POTEH_uc002zlj.1_Silent_p.R322R	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	487										skin(1)	1						TTCTGCTTTTCCTTGGTGGAA	0.433													45	215					0	0	0.000781405	0	0
XKR3	150165	broad.mit.edu	37	22	17288923	17288923	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:17288923C>T	uc002zlv.2	-	2	139	c.41G>A	c.(40-42)GGA>GAA	p.G14E	XKR3_uc011agf.1_Missense_Mutation_p.G14E	NM_175878	NP_787074	Q5GH77	XKR3_HUMAN	X Kell blood group precursor-related family,	14						integral to membrane|plasma membrane				large_intestine(1)|ovary(1)|skin(1)	3	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGAAACTCCTCCTGTGCTTTC	0.418													28	80					0	0	0.0024448	0	0
PEX26	55670	broad.mit.edu	37	22	18561251	18561251	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:18561251C>T	uc002znp.3	+	2	318	c.109C>T	c.(109-111)CTT>TTT	p.L37F	TUBA8_uc002znr.2_5'UTR|PEX26_uc002znq.3_Missense_Mutation_p.L37F|uc002zns.2_Missense_Mutation_p.R91K|PEX26_uc002znt.2_Missense_Mutation_p.L37F	NM_017929	NP_060399	Q7Z412	PEX26_HUMAN	peroxisome biogenesis factor 26	37	Cytoplasmic (Potential).				protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			skin(1)	1						ggccgTGGACCTTCTGGAGGA	0.612													3	5					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	22	18844923	18844923	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:18844923C>T	uc002zoe.2	+	4		c.2177C>T			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		GCGTTCACGTCCATCTCGCTC	0.572													22	38					0	0	0.00178596	0	0
DGCR2	9993	broad.mit.edu	37	22	19052576	19052576	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:19052576G>A	uc002zoq.1	-	4	581	c.333C>T	c.(331-333)TTC>TTT	p.F111F	DGCR2_uc002zor.1_Intron|DGCR2_uc011agr.1_Intron	NM_005137	NP_005128	P98153	IDD_HUMAN	integral membrane protein DGCR2 precursor	111	Extracellular (Potential).				cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			large_intestine(1)	1	Colorectal(54;0.0993)					ACTTCCCTAGGAAACATAAAG	0.547													6	24					0	0	0.00116845	0	0
GNB1L	54584	broad.mit.edu	37	22	19789715	19789715	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:19789715G>A	uc002zqe.1	-	6	935	c.541C>T	c.(541-543)CTT>TTT	p.L181F	GNB1L_uc002zqd.1_Missense_Mutation_p.L37F|GNB1L_uc002zqf.1_Missense_Mutation_p.L181F	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	181	WD 3.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					CCGGCCAGAAGGAGTGGGCGG	0.642													17	37					0	0	0.000958276	0	0
C22orf29	79680	broad.mit.edu	37	22	19839296	19839297	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:19839296_19839297GG>AA	uc002zqg.2	-	2	1087_1088	c.488_489CC>TT	c.(487-489)CCC>CTT	p.P163L	GNB1L_uc002zqd.1_Intron|GNB1L_uc002zqe.1_Intron|GNB1L_uc002zqf.1_Intron|C22orf29_uc002zqh.2_Missense_Mutation_p.P163L|C22orf29_uc002zqi.2_Missense_Mutation_p.P163L|C22orf29_uc010grt.1_Intron	NM_024627	NP_078903	Q7L3V2	CV029_HUMAN	hypothetical protein LOC79680	163											0	Colorectal(54;0.0993)					CGTCAGGCAGGGGCAGGTCCCC	0.584													35	60					0	0	6.4e-05	0	0
DGCR8	54487	broad.mit.edu	37	22	20094149	20094149	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:20094149G>C	uc002zri.2	+	11	2274	c.1924G>C	c.(1924-1926)GAA>CAA	p.E642Q	DGCR8_uc010grz.2_Missense_Mutation_p.E609Q|DGCR8_uc002zrj.2_Missense_Mutation_p.E285Q	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	642	DRBM 2.|Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TATCAAGTTTGAAGTGGTTCC	0.537													24	45					0	0	0.000720815	0	0
ZNF74	7625	broad.mit.edu	37	22	20760622	20760622	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:20760622C>T	uc010gsm.2	+	6	1511	c.1299C>T	c.(1297-1299)CTC>CTT	p.L433L	ZNF74_uc002zsg.2_Silent_p.L362L|ZNF74_uc002zsh.2_Silent_p.L433L|ZNF74_uc002zsi.2_Silent_p.L362L|ZNF74_uc010gsn.2_Silent_p.L362L	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	433	C2H2-type 7.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCCTCACCCTCCACCAGAGGA	0.642													22	39					0	0	0.00152264	0	0
HIC2	23119	broad.mit.edu	37	22	21800468	21800468	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:21800468G>A	uc002zur.3	+	3	1514	c.1284G>A	c.(1282-1284)CGG>CGA	p.R428R	HIC2_uc002zus.3_Silent_p.R428R	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	428					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				ACATGTACCGGCAGGAGGGCT	0.632													16	55					0	0	0.00121646	0	0
LOC96610	96610	broad.mit.edu	37	22	23214005	23214005	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:23214005G>A	uc011aim.1	+	326		c.14082G>A								Parts of antibodies, mostly variable regions.												0						CCATCGAATGGTATCAACAGA	0.572													65	87					0	0	0.000781405	0	0
LOC96610	96610	broad.mit.edu	37	22	23237931	23237931	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:23237931G>A	uc011aim.1	+	363		c.15334G>A			uc011aiw.1_3'UTR|uc010gtu.1_RNA|uc002zws.2_Intron					Parts of antibodies, mostly variable regions.												0						CCAGGGGAGGGGTCTCTCTCC	0.527													9	11					0	0	0.000274275	0	0
LOC96610	96610	broad.mit.edu	37	22	23264834	23264834	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:23264834G>A	uc011aim.1	+	379		c.16655G>A								Parts of antibodies, mostly variable regions.												0						AGCCAACAAGGCCACACTGGT	0.632													26	48					0	0	0.00106085	0	0
CABIN1	23523	broad.mit.edu	37	22	24573578	24573578	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:24573578C>T	uc002zzi.1	+	36	6439	c.6312C>T	c.(6310-6312)CCC>CCT	p.P2104P	CABIN1_uc002zzj.1_Silent_p.P2025P|CABIN1_uc002zzl.1_Silent_p.P2104P|CABIN1_uc010gul.1_Silent_p.P42P	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	2104					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CCAAGGCCCCCAGCAGTGGGA	0.667													44	31					0	0	0.000781405	0	0
GGT1	2678	broad.mit.edu	37	22	25019187	25019187	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:25019187G>A	uc003aan.1	+	10	1334	c.847G>A	c.(847-849)GGG>AGG	p.G283R	GGT1_uc003aas.1_Missense_Mutation_p.G283R|GGT1_uc003aat.1_Missense_Mutation_p.G283R|GGT1_uc003aau.1_Missense_Mutation_p.G283R|GGT1_uc003aav.1_Missense_Mutation_p.G283R|GGT1_uc003aaw.1_Missense_Mutation_p.G283R|GGT1_uc003aax.1_Missense_Mutation_p.G283R	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	283	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	GCCGCTCAGCGGGCCCGTGCT	0.627													10	4					0	0	0.00136819	0	0
SGSM1	129049	broad.mit.edu	37	22	25280142	25280142	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:25280142G>A	uc003abg.2	+	16	1940	c.1783G>A	c.(1783-1785)GAG>AAG	p.E595K	SGSM1_uc003abh.2_Missense_Mutation_p.E595K|SGSM1_uc010guu.1_Missense_Mutation_p.E540K|SGSM1_uc003abj.2_Missense_Mutation_p.E540K|SGSM1_uc003abi.1_Missense_Mutation_p.E515K	NM_001039948	NP_001035037	Q2NKQ1	SGSM1_HUMAN	RUN and TBC1 domain containing 2 isoform 1	595						Golgi apparatus	Rab GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)	5						CAGGATCTGGGAGCAGTACCT	0.552													19	37					0	0	0.00152264	0	0
LRP5L	91355	broad.mit.edu	37	22	25753393	25753393	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:25753393G>A	uc003abs.2	-	2	2732	c.267C>T	c.(265-267)GGC>GGT	p.G89G	LRP5L_uc011ajz.1_Silent_p.G89G|LRP5L_uc010guw.1_Silent_p.G89G	NM_182492	NP_872298	A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein	89	LDL-receptor class B 3.										0						AGTACGTGAGGCTGGAGAAGA	0.602													24	56					0	0	0.00106085	0	0
LRP5L	91355	broad.mit.edu	37	22	25755850	25755850	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:25755850G>A	uc003abs.2	-	1	2675	c.210C>T	c.(208-210)ATC>ATT	p.I70I	LRP5L_uc011ajz.1_Silent_p.I70I|LRP5L_uc010guw.1_Silent_p.I70I	NM_182492	NP_872298	A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein	70	LDL-receptor class B 2.										0						CTGACACCAGGATCTTGTGGG	0.612													58	118					0	0	0.000781405	0	0
MYO18B	84700	broad.mit.edu	37	22	26423593	26423593	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:26423593G>A	uc003abz.1	+	43	7903	c.7653G>A	c.(7651-7653)GGG>GGA	p.G2551G	MYO18B_uc003aca.1_Silent_p.G2432G|MYO18B_uc010guy.1_Silent_p.G2433G|MYO18B_uc010guz.1_Silent_p.G2431G|MYO18B_uc011aka.1_Silent_p.G1705G|MYO18B_uc011akb.1_Silent_p.G2064G|MYO18B_uc010gva.1_Silent_p.G534G|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2551						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CAGGGACGGGGAGGAAAGACG	0.547													19	22					0	0	0.00121646	0	0
MIR548J	100302262	broad.mit.edu	37	22	26951283	26951283	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:26951283G>A	hsa-mir-548j|MI0006345	-			c.7G>A			TPST2_uc003acw.2_Intron|TPST2_uc003acx.2_Intron|TPST2_uc011akf.1_Intron																	0						CTATTCACTGGCTGCCCACCT	0.159													9	15					0	0	0.000274275	0	0
HSCB	150274	broad.mit.edu	37	22	29139939	29139940	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:29139939_29139940CC>TT	uc003aea.2	+	2	347_348	c.306_307CC>TT	c.(304-309)CACCCA>CATTCA	p.P103S	CHEK2_uc003adt.1_5'Flank|CHEK2_uc003adu.1_5'Flank|CHEK2_uc003adv.1_5'Flank|CHEK2_uc003adw.1_5'Flank|CHEK2_uc003adx.1_5'Flank|CHEK2_uc003ady.1_5'Flank|CHEK2_uc003adz.1_5'Flank	NM_172002	NP_741999	Q8IWL3	HSC20_HUMAN	J-type co-chaperone HSC20 precursor	103	J.			HPD->AAA: Does not interact with HSPA9. Does not inhibit interaction with ISCU.	iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)	1						GTCTTGTCCACCCAGATTTCTT	0.485													46	105					0	0	6.4e-05	0	0
KREMEN1	83999	broad.mit.edu	37	22	29533461	29533461	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:29533461C>T	uc011akm.1	+	6	776	c.763C>T	c.(763-765)CAC>TAC	p.H255Y	KREMEN1_uc003ael.2_Missense_Mutation_p.H255Y|KREMEN1_uc011akn.1_Missense_Mutation_p.H138Y	NM_032045	NP_114434	Q96MU8	KREM1_HUMAN	kringle-containing transmembrane protein 1	253	Extracellular (Potential).|CUB.				cell communication|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane|membrane fraction	protein binding			ovary(3)|lung(2)	5						CTCCCACATCCACTTCAGCTT	0.612													46	41					0	0	0.000781405	0	0
AP1B1	162	broad.mit.edu	37	22	29747218	29747218	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:29747218T>C	uc003afj.2	-	9	1281	c.1097A>G	c.(1096-1098)GAT>GGT	p.D366G	AP1B1_uc003afi.2_Missense_Mutation_p.D366G|AP1B1_uc003afk.2_Missense_Mutation_p.D366G|AP1B1_uc003afl.2_Missense_Mutation_p.D366G|AP1B1_uc011ako.1_5'Flank	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	366					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						AAAGTCCACATCCACTTCTGT	0.567													5	277					0	0	0.00116845	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30722746	30722746	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:30722746C>T	uc011akt.1	-	1	149	c.125G>A	c.(124-126)GGG>GAG	p.G42E	TBC1D10A_uc010gvu.2_Missense_Mutation_p.G42E|TBC1D10A_uc003ahk.3_Missense_Mutation_p.G42E	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	42						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CGAGTCAGACCCGAGAGAGCT	0.617													20	50					0	0	0.000878237	0	0
SEC14L3	266629	broad.mit.edu	37	22	30867904	30867904	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:30867904C>T	uc003ahy.2	-	1	131	c.42G>A	c.(40-42)GAG>GAA	p.E14E	SEC14L3_uc003ahz.2_5'UTR|SEC14L3_uc003aia.2_5'UTR|SEC14L3_uc003aib.2_5'UTR	NM_174975	NP_777635	Q9UDX4	S14L3_HUMAN	SEC14-like 3	14						integral to membrane|intracellular	lipid binding|transporter activity			ovary(3)|pancreas(1)|skin(1)	5					Vitamin E(DB00163)	TGGCCAGGGTCTCTGCCTGTT	0.627													62	79					0	0	0.000781405	0	0
OSBP2	23762	broad.mit.edu	37	22	31091279	31091280	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:31091279_31091280CC>TT	uc003aiy.1	+	1	487_488	c.383_384CC>TT	c.(382-384)TCC>TTT	p.S128F	OSBP2_uc011ala.1_Intron|OSBP2_uc010gwc.1_Intron|OSBP2_uc003aix.1_Missense_Mutation_p.S128F|OSBP2_uc011alb.1_Missense_Mutation_p.S128F|OSBP2_uc003aiz.1_Missense_Mutation_p.S128F	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	128					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						GAGCCGCTCTCCCGGGCGGTGG	0.668													38	42					0	0	6.4e-05	0	0
FBXO7	25793	broad.mit.edu	37	22	32894166	32894166	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:32894166C>T	uc003amq.2	+	9	1501	c.1218C>T	c.(1216-1218)TCC>TCT	p.S406S	FBXO7_uc003amr.2_Silent_p.S292S|FBXO7_uc003ams.2_Silent_p.S250S|FBXO7_uc003amt.2_Silent_p.S327S|FBXO7_uc003amu.2_Silent_p.S292S|FBXO7_uc003amv.2_Silent_p.S105S	NM_012179	NP_036311	Q9Y3I1	FBX7_HUMAN	F-box only protein 7 isoform 1	406					cell death|regulation of protein stability|ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						GAAAAGAATCCCCGAAAGGGC	0.453													31	130					0	0	0.00283554	0	0
ISX	91464	broad.mit.edu	37	22	35478537	35478537	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:35478537C>T	uc003anj.2	+	2	1207	c.256C>T	c.(256-258)CGT>TGT	p.R86C	ISX_uc011amg.1_Missense_Mutation_p.R74C	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	86	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						GCGGAGGGTTCGTACCACCTT	0.557													77	64					0	0	0.000781405	0	0
APOL5	80831	broad.mit.edu	37	22	36116701	36116701	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:36116701C>T	uc003aof.2	+	2	142	c.142C>T	c.(142-144)CCC>TCC	p.P48S		NM_030642	NP_085145	Q9BWW9	APOL5_HUMAN	apolipoprotein L5	48					lipid metabolic process|lipid transport|lipoprotein metabolic process	cytoplasm|extracellular region	high-density lipoprotein particle binding|lipid binding|protein binding				0						acctgagttccgtgagggcag	0.224													22	25					0	0	0.00188189	0	0
APOL1	8542	broad.mit.edu	37	22	36653381	36653381	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:36653381C>T	uc003apf.2	+	4	283	c.115C>T	c.(115-117)CCA>TCA	p.P39S	APOL1_uc011amn.1_5'UTR|APOL1_uc003apc.2_RNA|APOL1_uc003ape.2_Missense_Mutation_p.P55S|APOL1_uc011amo.1_Intron|APOL1_uc011amp.1_Missense_Mutation_p.P39S|APOL1_uc011amq.1_Missense_Mutation_p.P21S|APOL1_uc010gwx.2_5'UTR	NM_003661	NP_003652	O14791	APOL1_HUMAN	apolipoprotein L1 isoform a precursor	39					cholesterol metabolic process|cytolysis|innate immune response|killing of cells of other organism|lipid transport|lipoprotein metabolic process	high-density lipoprotein particle|very-low-density lipoprotein particle	chloride channel activity|lipid binding|protein binding			breast(2)|ovary(1)	3						ACAAAACGTTCCAAGTGGGAC	0.562													60	75					0	0	0.000781405	0	0
EIF3D	8664	broad.mit.edu	37	22	36912528	36912528	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:36912528G>A	uc003apq.2	-	12	1319	c.1203C>T	c.(1201-1203)TCC>TCT	p.S401S	EIF3D_uc011amr.1_Silent_p.S228S|EIF3D_uc003apr.2_Silent_p.S401S|EIF3D_uc011ams.1_Silent_p.S304S|EIF3D_uc011amt.1_Silent_p.S352S	NM_003753	NP_003744	O15371	EIF3D_HUMAN	eukaryotic translation initiation factor 3	401						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			pancreas(1)	1						GGCTCACCCTGGAATCCCACT	0.493													69	107					0	0	0.000781405	0	0
CSF2RB	1439	broad.mit.edu	37	22	37333949	37333949	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:37333949G>A	uc003aqa.3	+	14	2316	c.2099G>A	c.(2098-2100)GGG>GAG	p.G700E	CSF2RB_uc003aqc.3_Missense_Mutation_p.G706E	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	700	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	ATGAGCTCTGGGGACACTGAG	0.617													42	50					0	0	0.0025221	0	0
MPST	4357	broad.mit.edu	37	22	37420607	37420607	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:37420607C>T	uc003aqj.2	+	3	763	c.351C>T	c.(349-351)TTC>TTT	p.F117F	MPST_uc003aqi.1_Silent_p.F117F|MPST_uc003aqm.2_Silent_p.F117F|MPST_uc011amu.1_Silent_p.F137F|MPST_uc003aql.2_Silent_p.F117F|MPST_uc003aqn.2_Silent_p.F117F|MPST_uc003aqo.2_Silent_p.F117F	NM_001130517	NP_001123989	P25325	THTM_HUMAN	mercaptopyruvate sulfurtransferase isoform 2	117	Rhodanese 1.				cyanate catabolic process|response to toxin		3-mercaptopyruvate sulfurtransferase activity|thiosulfate sulfurtransferase activity				0						GGTGGATGTTCCGCGCCTTCG	0.706													10	10					0	0	0.000673444	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37485790	37485790	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:37485790G>A	uc003aqs.1	-	7	805	c.691C>T	c.(691-693)CAG>TAG	p.Q231*	TMPRSS6_uc003aqt.1_Nonsense_Mutation_p.Q222*|TMPRSS6_uc003aqu.2_Nonsense_Mutation_p.Q222*	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	231	CUB 1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						CGGAGGACCTGGCCCTGGCCC	0.672													18	16					0	0	0.000958276	0	0
IL2RB	3560	broad.mit.edu	37	22	37532325	37532325	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:37532325C>T	uc003aqv.1	-	7	777	c.646G>A	c.(646-648)GAG>AAG	p.E216K		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	216	Extracellular (Potential).|Fibronectin type-III.				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GTCGTGAACTCGCCTTGCAGA	0.627													15	14					0	0	0.00244969	0	0
SSTR3	6753	broad.mit.edu	37	22	37603068	37603069	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:37603068_37603069CC>TT	uc003ara.2	-	2	836_837	c.774_775GG>AA	c.(772-777)ATGGTG>ATAATG	p.258_259MV>IM	SSTR3_uc003arb.2_Missense_Mutation_p.258_259MV>IM	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	258_259	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						ACGGCCACCACCATGCGCGTGA	0.673													52	47					0	0	6.4e-05	0	0
CARD10	29775	broad.mit.edu	37	22	37888516	37888516	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:37888516C>T	uc003asx.1	-	18	2680	c.2677G>A	c.(2677-2679)GGA>AGA	p.G893R	CARD10_uc003ast.1_RNA|CARD10_uc003asu.1_5'UTR|CARD10_uc003asv.1_5'UTR|CARD10_uc011ank.1_Missense_Mutation_p.G211R|CARD10_uc003asw.1_Missense_Mutation_p.G607R|CARD10_uc003asy.1_Missense_Mutation_p.G893R	NM_014550	NP_055365	Q9BWT7	CAR10_HUMAN	caspase recruitment domain protein 10	893					activation of NF-kappaB-inducing kinase activity|protein complex assembly|regulation of apoptosis	CBM complex	receptor signaling complex scaffold activity			upper_aerodigestive_tract(1)|lung(1)|breast(1)|ovary(1)|prostate(1)|kidney(1)	6	Melanoma(58;0.0574)					TTGGGGGCTCCAGGCGCTGAG	0.672													33	78					0	0	0.00128727	0	0
TRIOBP	11078	broad.mit.edu	37	22	38130867	38130867	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:38130867G>A	uc003atr.2	+	9	4795	c.4524G>A	c.(4522-4524)AAG>AAA	p.K1508K	TRIOBP_uc003atu.2_Silent_p.K1336K	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	1508					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AACTAGGAAAGAGAAGCCCAC	0.647													35	24					0	0	0.000692331	0	0
SOX10	6663	broad.mit.edu	37	22	38370151	38370151	+	Missense_Mutation	SNP	G	A	A	rs74315518		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:38370151G>A	uc003aun.1	-	4	1030	c.752C>T	c.(751-753)TCG>TTG	p.S251L	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Missense_Mutation_p.S251L	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	251						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					TGCCTTGCCCGACTGCAGCTC	0.652													103	168					0	0	0.000781405	0	0
SOX10	6663	broad.mit.edu	37	22	38370153	38370153	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:38370153C>A	uc003aun.1	-	4	1028	c.750G>T	c.(748-750)CAG>CAT	p.Q250H	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Missense_Mutation_p.Q250H	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	250						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					CCTTGCCCGACTGCAGCTCTG	0.647													100	167					7.98965e-42	2.7581e-41	0.000781405	1	0
APOBEC3D	140564	broad.mit.edu	37	22	39421256	39421256	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:39421256C>T	uc011aoe.1	+	3	446	c.392C>T	c.(391-393)TCT>TTT	p.S131F	APOBEC3D_uc011aod.1_Missense_Mutation_p.S131F|APOBEC3D_uc011aof.1_Intron|APOBEC3D_uc003awu.3_Intron|APOBEC3D_uc003awt.3_Missense_Mutation_p.S131F|APOBEC3D_uc010gxu.2_Intron	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	131					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					CTGACCATCTCTGCCGCCCGC	0.562													44	70					0	0	0.000781405	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39427956	39427956	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:39427956C>T	uc011aoe.1	+	6	1074	c.1020C>T	c.(1018-1020)TCC>TCT	p.S340S	APOBEC3D_uc011aof.1_Silent_p.S156S|APOBEC3D_uc003awu.3_Silent_p.S156S|APOBEC3D_uc003awt.3_Silent_p.S340S|APOBEC3D_uc010gxu.2_Silent_p.S136S	NM_152426	NP_689639	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	340					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding				0	Melanoma(58;0.04)					AAGGGGCCTCCGTGAAGATCA	0.612													55	46					0	0	0.000781405	0	0
TAB1	10454	broad.mit.edu	37	22	39771966	39771966	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:39771966C>T	uc003axr.2	+	2	1807	c.25C>T	c.(25-27)CCT>TCT	p.P9S	SYNGR1_uc003axo.3_Intron|SYNGR1_uc003axp.3_Intron|SYNGR1_uc003axq.3_Intron|SYNGR1_uc003axs.3_Intron	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	Error:Variant_position_missing_in_Q15750_after_alignment					activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CTTGAATGTCCCTCTGTTCCT	0.617													36	54					0	0	0.000953801	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41739503	41739503	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:41739503C>T	uc003azw.2	+	13	1598	c.1382C>T	c.(1381-1383)TCG>TTG	p.S461L	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	477					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						CTCCGGAGCTCGGAGGACCAG	0.677													43	46					0	0	0.0025221	0	0
PPPDE2	27351	broad.mit.edu	37	22	42003275	42003275	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:42003275G>A	uc003ban.1	-	3	244	c.171C>T	c.(169-171)AGC>AGT	p.S57S	PPPDE2_uc011apb.1_Intron	NM_015704	NP_056519	Q6ICB0	PPDE2_HUMAN	PPPDE peptidase domain containing 2	57	PPPDE peptidase.										0						CCGGGGGGCAGCTGGAGATAC	0.527													32	22					0	0	0.00283554	0	0
TTLL1	25809	broad.mit.edu	37	22	43459883	43459884	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:43459883_43459884GG>TT	uc003bdi.2	-	7	923_924	c.682_683CC>AA	c.(682-684)CCG>AAG	p.P228K	TTLL1_uc010gzh.2_Missense_Mutation_p.P228K|TTLL1_uc003bdj.2_Missense_Mutation_p.P114K|TTLL1_uc003bdh.2_Missense_Mutation_p.P190K	NM_012263	NP_036395	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	228	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		ACTGGTACTCGGGGTGTATTTC	0.46													9	188					0	0	6.4e-05	0	0
PPARA	5465	broad.mit.edu	37	22	46594462	46594462	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:46594462C>T	uc003bgw.1	+	4	448	c.182C>T	c.(181-183)CCT>CTT	p.P61L	PPARA_uc003bgx.1_Missense_Mutation_p.P61L|PPARA_uc010hab.1_Missense_Mutation_p.P61L|PPARA_uc003bgy.1_RNA|PPARA_uc003bgz.1_RNA|PPARA_uc003bha.2_Missense_Mutation_p.P61L|PPARA_uc003bhb.1_Missense_Mutation_p.P61L|PPARA_uc010hac.1_5'UTR	NM_005036	NP_005027	Q07869	PPARA_HUMAN	peroxisome proliferative activated receptor,	61					fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	GGAAGCTGTCCTGGCTCAGAT	0.413													61	62					0	0	0.000781405	0	0
PKDREJ	10343	broad.mit.edu	37	22	46653000	46653000	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:46653000C>T	uc003bhh.2	-	1	6220	c.6220G>A	c.(6220-6222)GAT>AAT	p.D2074N		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	2074	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AGGCGCACATCGTAGAAGAAT	0.463													20	29					0	0	0.00188189	0	0
PKDREJ	10343	broad.mit.edu	37	22	46657351	46657351	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:46657351C>A	uc003bhh.2	-	1	1869	c.1869G>T	c.(1867-1869)TTG>TTT	p.L623F		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	623	Extracellular (Potential).|REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		ACTGAGGCCCCAAGTACAGGA	0.448													7	132					0.00198382	0.00668814	0.00198382	1	0
MLC1	23209	broad.mit.edu	37	22	50506907	50506907	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr22:50506907G>A	uc003bjg.1	-	10	1122	c.849C>T	c.(847-849)ATC>ATT	p.I283I	MLC1_uc011arl.1_Silent_p.I231I|MLC1_uc003bjh.1_Silent_p.I283I|MLC1_uc011arm.1_Silent_p.I253I|MLC1_uc011arn.1_Silent_p.I204I|MLC1_uc011aro.1_Silent_p.I249I	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	283						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CGATTCTCATGATGCTGAATG	0.502													109	100					0	0	0.000781405	0	0
CNTN6	27255	broad.mit.edu	37	3	1414033	1414033	+	Missense_Mutation	SNP	G	A	A	rs138019615	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:1414033G>A	uc003boz.2	+	13	1810	c.1543G>A	c.(1543-1545)GAG>AAG	p.E515K	CNTN6_uc011asj.1_Missense_Mutation_p.E443K|CNTN6_uc003bpa.2_Missense_Mutation_p.E515K	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	515	Ig-like C2-type 6.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		TACAGTTGGCGAGAGTATAGT	0.388													34	31					0	0	0.00148497	0	0
CNTN4	152330	broad.mit.edu	37	3	2908625	2908625	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:2908625G>A	uc003bpc.2	+	7	865	c.644G>A	c.(643-645)AGA>AAA	p.R215K	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.R215K	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	215					axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		CTAATATTGAGAAATGATGGT	0.393													13	31					0	0	0.00185496	0	0
ITPR1	3708	broad.mit.edu	37	3	4744524	4744524	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:4744524C>T	uc003bqa.2	+	36	4868	c.4520C>T	c.(4519-4521)CCT>CTT	p.P1507L	ITPR1_uc010hca.1_Missense_Mutation_p.P1492L|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.P438L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	1516	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ACTCGCCAGCCTGTCTTTGTG	0.473													8	19					0	0	0.000157383	0	0
IL17RE	132014	broad.mit.edu	37	3	9948696	9948696	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:9948696C>T	uc003btu.2	+	7	695	c.578C>T	c.(577-579)ACC>ATC	p.T193I	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Missense_Mutation_p.T193I|IL17RE_uc011atn.1_RNA|IL17RE_uc003btw.2_Missense_Mutation_p.T193I|IL17RE_uc003btx.2_Missense_Mutation_p.T77I|IL17RE_uc010hcq.2_Missense_Mutation_p.T193I|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	193	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		ATTCGGGTGACCATATCTTCA	0.572													25	48					0	0	0.000586117	0	0
IL17RC	84818	broad.mit.edu	37	3	9962213	9962213	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:9962213G>A	uc003bua.2	+	6	953	c.717G>A	c.(715-717)GGG>GGA	p.G239G	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_RNA|IL17RC_uc011ato.1_RNA|IL17RC_uc010hcs.2_Silent_p.G143G|IL17RC_uc003btz.2_Silent_p.G168G|IL17RC_uc011atp.1_Silent_p.G39G|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Silent_p.G168G|IL17RC_uc010hct.2_Silent_p.G168G|IL17RC_uc010hcu.2_Silent_p.G168G|IL17RC_uc010hcv.2_Silent_p.G168G|IL17RC_uc011atq.1_Silent_p.G168G|IL17RC_uc003buc.2_5'UTR	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	239	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						CTGCCCTAGGGAGTGAGGTAC	0.597													6	3					0	0	0.000157383	0	0
FANCD2	2177	broad.mit.edu	37	3	10136910	10136910	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:10136910C>T	uc003buw.2	+	41	4068	c.3990C>T	c.(3988-3990)ACC>ACT	p.T1330T	FANCD2_uc003bux.1_Silent_p.T1330T|FANCD2_uc003buy.1_Silent_p.T1330T|FANCD2_uc010hcw.1_RNA|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1330					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TACTGGAAACCTTCCAGTTGG	0.428			D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				11	14					0	0	0.00136819	0	0
VHL	7428	broad.mit.edu	37	3	10191547	10191547	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:10191547C>T	uc003bvc.2	+	3	753	c.540C>T	c.(538-540)ATC>ATT	p.I180I	VHL_uc003bvd.2_Silent_p.I139I	NM_000551	NP_000542	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor isoform 1	180			I -> V (in VHLD; type I).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.I180N(4)|p.I180fs*22(2)|p.L178_V181del(1)|p.I180fs*21(1)		kidney(1273)|soft_tissue(24)|adrenal_gland(15)|large_intestine(13)|pancreas(5)|endometrium(4)|thyroid(3)|upper_aerodigestive_tract(3)|central_nervous_system(2)|lung(2)|pleura(1)|paratesticular_tissues(1)	1346				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		GACTGGACATCGTCAGGTCGC	0.517		1	D|Mis|N|F|S		renal|hemangioma|pheochromocytoma	renal|hemangioma|pheochromocytoma			von_Hippel-Lindau_disease|Chuvash_Polycythemia_|Pheochromocytoma_(Adrenal)_Familial				10	28					0	0	0.000442599	0	0
TATDN2	9797	broad.mit.edu	37	3	10311961	10311961	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:10311961C>T	uc003bvg.2	+	4	1676	c.1095C>T	c.(1093-1095)ACC>ACT	p.T365T	TATDN2_uc003bvf.2_Silent_p.T365T|TATDN2_uc011atr.1_Silent_p.T365T|TATDN2_uc011ats.1_RNA|TATDN2_uc011att.1_RNA	NM_014760	NP_055575	Q93075	TATD2_HUMAN	TatD DNase domain containing 2	365						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			pancreas(2)	2						CCTTCACCACCGACTATGTCA	0.532													67	58					0	0	0.000781405	0	0
ATP2B2	491	broad.mit.edu	37	3	10452327	10452327	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:10452327G>A	uc003bvt.2	-	3	811	c.372C>T	c.(370-372)TAC>TAT	p.Y124Y	ATP2B2_uc003bvv.2_Silent_p.Y124Y|ATP2B2_uc003bvw.2_Silent_p.Y124Y|ATP2B2_uc010hdp.2_Silent_p.Y124Y|ATP2B2_uc010hdo.2_5'UTR	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	124	Extracellular (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CGGGCGGGTGGTAGAAGGACA	0.652													48	125					0	0	0.000781405	0	0
ATG7	10533	broad.mit.edu	37	3	11350518	11350518	+	Missense_Mutation	SNP	C	T	T	rs143294564		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:11350518C>T	uc003bwc.2	+	5	511	c.394C>T	c.(394-396)CTC>TTC	p.L132F	ATG7_uc003bwd.2_Missense_Mutation_p.L132F|ATG7_uc011aum.1_Missense_Mutation_p.L132F	NM_006395	NP_006386	O95352	ATG7_HUMAN	APG7 autophagy 7-like isoform a	132					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)	1						CAACAAGTTCCTCCTCTTGAC	0.473													58	47					0	0	0.000781405	0	0
TIMP4	7079	broad.mit.edu	37	3	12195891	12195891	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:12195891T>C	uc003bwo.2	-	4	720	c.413A>G	c.(412-414)GAG>GGG	p.E138G	SYN2_uc003bwl.1_Intron|SYN2_uc003bwm.2_Intron|SYN2_uc003bwn.2_Intron	NM_003256	NP_003247	Q99727	TIMP4_HUMAN	tissue inhibitor of metalloproteinase 4	138	NTR.						metal ion binding|metalloendopeptidase inhibitor activity				0						GGACAGGTCCTCCCAGGGCTC	0.493													51	259					0	0	0.000781405	0	0
TIMP4	7079	broad.mit.edu	37	3	12195893	12195894	+	Missense_Mutation	DNP	CC	GT	GT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:12195893_12195894CC>GT	uc003bwo.2	-	4	717_718	c.410_411GG>AC	c.(409-411)TGG>TAC	p.W137Y	SYN2_uc003bwl.1_Intron|SYN2_uc003bwm.2_Intron|SYN2_uc003bwn.2_Intron	NM_003256	NP_003247	Q99727	TIMP4_HUMAN	tissue inhibitor of metalloproteinase 4	137	NTR.						metal ion binding|metalloendopeptidase inhibitor activity				0						ACAGGTCCTCCCAGGGCTCGAT	0.49													54	259					0	0	6.4e-05	0	0
MKRN2	23609	broad.mit.edu	37	3	12616298	12616298	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:12616298T>A	uc003bxd.2	+	5	706	c.650T>A	c.(649-651)ATG>AAG	p.M217K	MKRN2_uc003bxe.2_Missense_Mutation_p.M215K|MKRN2_uc011aus.1_Missense_Mutation_p.M174K	NM_014160	NP_054879	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	217	Makorin-type Cys-His.					intracellular	ligase activity|nucleic acid binding|zinc ion binding				0						CAGATCTGCATGTTGACGTTC	0.547													46	39					0	0	0.000781405	0	0
IQSEC1	9922	broad.mit.edu	37	3	12977612	12977612	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:12977612G>A	uc003bxt.2	-	3	955	c.946C>T	c.(946-948)CTG>TTG	p.L316L	IQSEC1_uc003bxu.3_Silent_p.L194L|IQSEC1_uc011auw.1_Silent_p.L302L	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	316					regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						GAGAGGGGCAGAGGGGGCGAC	0.677													48	35					0	0	0.000781405	0	0
NGLY1	55768	broad.mit.edu	37	3	25805596	25805596	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:25805596G>A	uc003cdl.2	-	3	561	c.453C>T	c.(451-453)AAC>AAT	p.N151N	NGLY1_uc010hfg.2_Silent_p.N151N|NGLY1_uc003cdm.2_Silent_p.N151N|NGLY1_uc011awo.1_Silent_p.N109N|NGLY1_uc003cdk.2_RNA	NM_018297	NP_060767	Q96IV0	NGLY1_HUMAN	N-glycanase 1 isoform 1	151					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)	1						GCCCTTGACGGTTCCTTGTGT	0.438													16	60					0	0	0.00074312	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751886	26751886	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:26751886C>T	uc003cdp.2	+	2	1312	c.723C>T	c.(721-723)TCC>TCT	p.S241S	LRRC3B_uc003cdq.2_Silent_p.S241S	NM_052953	NP_443185	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B precursor	241						integral to membrane				pancreas(2)|ovary(1)|skin(1)	4						ACTTGAAATCCCTGCCAAGCA	0.433													21	9					0	0	0.00229938	0	0
TRIM71	131405	broad.mit.edu	37	3	32932199	32932199	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:32932199G>A	uc003cff.2	+	4	1566	c.1503G>A	c.(1501-1503)AAG>AAA	p.K501K		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	501	Filamin.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						TCCAGGGTAAGGTGGCCTCCT	0.602													14	17					0	0	0.000308642	0	0
CCR4	1233	broad.mit.edu	37	3	32995250	32995250	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:32995250G>A	uc003cfg.1	+	2	504	c.336G>A	c.(334-336)ATG>ATA	p.M112I		NM_005508	NP_005499	P51679	CCR4_HUMAN	chemokine (C-C motif) receptor 4	112	Helical; Name=3; (Potential).				chemotaxis|elevation of cytosolic calcium ion concentration|immune response|inflammatory response	integral to plasma membrane				lung(1)	1						TGTGCAAGATGATTTCCTGGA	0.478													136	82					0	0	0.000781405	0	0
TRANK1	9881	broad.mit.edu	37	3	36872628	36872628	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:36872628C>T	uc003cgj.2	-	12	6966	c.6664G>A	c.(6664-6666)GAG>AAG	p.E2222K		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2772					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TCGTAAGACTCGCTGTTCCTC	0.547													32	85					0	0	0.00111076	0	0
DLEC1	9940	broad.mit.edu	37	3	38101301	38101301	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38101301G>A	uc003cho.1	+	3	652	c.631G>A	c.(631-633)GAT>AAT	p.D211N	DLEC1_uc003chp.1_Missense_Mutation_p.D211N|DLEC1_uc010hgv.1_Missense_Mutation_p.D211N|DLEC1_uc010hgw.1_5'Flank|DLEC1_uc003chq.1_5'Flank	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	211					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		CTCCCCAGAAGATTACTACAC	0.478													61	144					0	0	0.000781405	0	0
SCN5A	6331	broad.mit.edu	37	3	38592273	38592273	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38592273C>T	uc003cio.2	-	28	5784	c.5590G>A	c.(5590-5592)GAG>AAG	p.E1864K	SCN5A_uc003cin.2_Missense_Mutation_p.E1863K|SCN5A_uc003cil.3_Missense_Mutation_p.E1864K|SCN5A_uc010hhi.2_Missense_Mutation_p.E1846K|SCN5A_uc010hhk.2_Missense_Mutation_p.E1831K|SCN5A_uc011ayr.1_Missense_Mutation_p.E1810K	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1864					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCCCCAGACTCCCCCAGGACC	0.557													32	80					0	0	0.00058488	0	0
SCN5A	6331	broad.mit.edu	37	3	38620944	38620944	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38620944C>T	uc003cio.2	-	18	3465	c.3271G>A	c.(3271-3273)GAT>AAT	p.D1091N	SCN5A_uc003cin.2_Missense_Mutation_p.D1090N|SCN5A_uc003cil.3_Missense_Mutation_p.D1091N|SCN5A_uc010hhi.2_Missense_Mutation_p.D1091N|SCN5A_uc010hhk.2_Missense_Mutation_p.D1090N|SCN5A_uc011ayr.1_Intron|SCN5A_uc010hhj.1_Missense_Mutation_p.D701N	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1091					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTCCTGGAATCCGGAGGGGCC	0.652													23	13					0	0	0.00127121	0	0
SCN5A	6331	broad.mit.edu	37	3	38622601	38622601	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38622601C>T	uc003cio.2	-	17	3243	c.3049G>A	c.(3049-3051)GAG>AAG	p.E1017K	SCN5A_uc003cin.2_Missense_Mutation_p.E1017K|SCN5A_uc003cil.3_Missense_Mutation_p.E1017K|SCN5A_uc010hhi.2_Missense_Mutation_p.E1017K|SCN5A_uc010hhk.2_Missense_Mutation_p.E1017K|SCN5A_uc011ayr.1_Missense_Mutation_p.E1017K|SCN5A_uc010hhj.1_Missense_Mutation_p.E628K	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1017					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGCACCTTCTCCGTCTCTGGG	0.697													19	9					0	0	0.000958276	0	0
SCN10A	6336	broad.mit.edu	37	3	38750978	38750978	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38750978C>T	uc003ciq.2	-	24	4272	c.4272G>A	c.(4270-4272)CAG>CAA	p.Q1424Q		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1424					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCTTTTTTTTCTGTTGATTGA	0.413													42	25					0	0	0.000781405	0	0
SCN10A	6336	broad.mit.edu	37	3	38755466	38755466	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38755466G>A	uc003ciq.2	-	21	3787	c.3787C>T	c.(3787-3789)CGA>TGA	p.R1263*		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1263	III.|Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCTTCAAATCGAGAAAGAGCC	0.368													37	38					0	0	0.00148497	0	0
SCN10A	6336	broad.mit.edu	37	3	38798333	38798333	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38798333C>T	uc003ciq.2	-	9	1122	c.1122G>A	c.(1120-1122)ATG>ATA	p.M374I		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	374	Helical; Name=S6 of repeat I; (Potential).|I.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAAAAAAGATCATATAGATTT	0.473													47	33					0	0	0.000781405	0	0
SCN11A	11280	broad.mit.edu	37	3	38888308	38888308	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38888308C>T	uc011ays.1	-	26	5452	c.5253G>A	c.(5251-5253)GTG>GTA	p.V1751V		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1751					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	cacccttggtcaccttCATCA	0.388													80	40					0	0	0.000781405	0	0
SCN11A	11280	broad.mit.edu	37	3	38961481	38961481	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:38961481C>T	uc011ays.1	-	7	1103	c.904G>A	c.(904-906)GAA>AAA	p.E302K		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	302	I.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCTTTCTTTTCAAAGCAATGG	0.333													16	59					0	0	0.000958276	0	0
CSRNP1	64651	broad.mit.edu	37	3	39184921	39184921	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:39184921G>A	uc003cjg.2	-	5	1609	c.1395C>T	c.(1393-1395)TTC>TTT	p.F465F	CSRNP1_uc003cjh.2_Silent_p.F465F	NM_033027	NP_149016	Q96S65	CSRN1_HUMAN	AXIN1 up-regulated 1	465					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(4)|skin(1)	5						CACCATTTAGGAAGCAGCTGG	0.597													11	18					0	0	0.000673444	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307251	39307251	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:39307251C>T	uc003cjl.2	-	2	842	c.750G>A	c.(748-750)ATG>ATA	p.M250I		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	250	Helical; Name=6; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		CCAGGAAAATCATAACGTTGT	0.468													59	36					0	0	0.000781405	0	0
ZNF197	10168	broad.mit.edu	37	3	44684197	44684197	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:44684197C>T	uc003cnm.2	+	6	1781	c.1575C>T	c.(1573-1575)CTC>CTT	p.L525L	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	525	C2H2-type 6.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		AGAAGAGCCTCATTCTGCACC	0.423													76	41					0	0	0.000781405	0	0
ZNF502	91392	broad.mit.edu	37	3	44762592	44762592	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:44762592C>T	uc011baa.1	+	4	538	c.283C>T	c.(283-285)CCT>TCT	p.P95S	ZNF502_uc003cns.2_Missense_Mutation_p.P95S|ZNF502_uc011bab.1_Missense_Mutation_p.P95S|ZNF502_uc003cnt.2_Missense_Mutation_p.P95S	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		AGAAGCACCCCCTGAAATTAT	0.423													17	40					0	0	0.000422831	0	0
ZNF502	91392	broad.mit.edu	37	3	44763609	44763609	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:44763609C>T	uc011baa.1	+	4	1555	c.1300C>T	c.(1300-1302)CCC>TCC	p.P434S	ZNF502_uc003cns.2_Missense_Mutation_p.P434S|ZNF502_uc011bab.1_Missense_Mutation_p.P434S|ZNF502_uc003cnt.2_Missense_Mutation_p.P434S	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	434					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TGGAGAAAAACCCTATAAATG	0.423													12	30					0	0	0.000978159	0	0
COL7A1	1294	broad.mit.edu	37	3	48614144	48614144	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:48614144G>A	uc003ctz.2	-	67	5666	c.5665C>T	c.(5665-5667)CCA>TCA	p.P1889S		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1889	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGGAGGCCTGGAGGCCCCTGG	0.612													16	0					0	0	0.00074312	0	0
COL7A1	1294	broad.mit.edu	37	3	48624918	48624918	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:48624918C>T	uc003ctz.2	-	22	2928	c.2927G>A	c.(2926-2928)TGG>TAG	p.W976*		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	976	Nonhelical region (NC1).|Fibronectin type-III 9.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CACTGGAGTCCAGGCCAAAGT	0.587													31	3					0	0	0.00283554	0	0
USP19	10869	broad.mit.edu	37	3	49154881	49154881	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:49154881G>A	uc003cwd.1	-	5	756	c.595C>T	c.(595-597)CCC>TCC	p.P199S	USP19_uc003cwa.2_Missense_Mutation_p.P5S|USP19_uc003cvz.3_Missense_Mutation_p.P199S|USP19_uc011bcg.1_Intron|USP19_uc003cwb.2_Missense_Mutation_p.P184S|USP19_uc003cwc.1_5'Flank|USP19_uc011bch.1_Missense_Mutation_p.P199S|USP19_uc011bci.1_Missense_Mutation_p.P184S	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	199	Cytoplasmic (Potential).|CS 1.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGGAGGGAGGGCCACGTGAGC	0.522													33	6					0	0	0.000814825	0	0
BSN	8927	broad.mit.edu	37	3	49699171	49699171	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:49699171C>T	uc003cxe.3	+	6	10007	c.9893C>T	c.(9892-9894)CCC>CTC	p.P3298L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3298					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCATACGATCCCCGCGGGAAG	0.602													42	6					0	0	0.00195071	0	0
RNF123	63891	broad.mit.edu	37	3	49753850	49753851	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:49753850_49753851CC>TT	uc003cxh.2	+	35	3526_3527	c.3440_3441CC>TT	c.(3439-3441)CCC>CTT	p.P1147L	RNF123_uc003cxi.2_RNA	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1147						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GACCACTATCCCATTCTGGTGG	0.639													126	20					0	0	6.4e-05	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50655029	50655029	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:50655029C>T	uc003day.1	+	4	629	c.33C>T	c.(31-33)GGC>GGT	p.G11G	MAPKAPK3_uc003daz.1_Silent_p.G11G|MAPKAPK3_uc003dba.1_Silent_p.G11G|MAPKAPK3_uc010hlr.1_Silent_p.G11G	NM_004635	NP_004626	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated	11					activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		AGCAGGGGGGCCCTGTGCCCC	0.716													25	8					0	0	0.000586117	0	0
DOCK3	1795	broad.mit.edu	37	3	51265502	51265502	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:51265502G>A	uc011bds.1	+	17	1653	c.1630G>A	c.(1630-1632)GAG>AAG	p.E544K		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	544	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGATATTCACGAGCTTTATGT	0.478													32	0					0	0	0.00058488	0	0
GRM2	2912	broad.mit.edu	37	3	51749229	51749229	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:51749229G>A	uc010hlv.2	+	4	1679	c.1440G>A	c.(1438-1440)CTG>CTA	p.L480L	GRM2_uc003dbo.3_5'UTR|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	480	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCTTGACTCTGGACACCAGCC	0.617													9	0					0	0	0.000442599	0	0
STAB1	23166	broad.mit.edu	37	3	52538520	52538520	+	Silent	SNP	C	T	T	rs113269624		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:52538520C>T	uc003dej.2	+	11	1268	c.1194C>T	c.(1192-1194)ACC>ACT	p.T398T	STAB1_uc003dei.1_Silent_p.T398T	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	398	Extracellular (Potential).|FAS1 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCCTTTCACCGTGCTGGTGC	0.637													27	4					0	0	0.00178596	0	0
PBRM1	55193	broad.mit.edu	37	3	52582135	52582135	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:52582135A>T	uc003des.2	-	30	5026	c.5014T>A	c.(5014-5016)TTG>ATG	p.L1672M	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.L1565M|PBRM1_uc003der.2_Missense_Mutation_p.L1585M|PBRM1_uc003det.2_Missense_Mutation_p.L1580M|PBRM1_uc003deu.2_Missense_Mutation_p.L1635M|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.L1617M|PBRM1_uc010hmk.1_Missense_Mutation_p.L1592M|PBRM1_uc003dey.2_Missense_Mutation_p.L1565M	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1672					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		CGGAGCATCAAATCTCGAAGG	0.478			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								79	16					0	0	0.000781405	0	0
NEK4	6787	broad.mit.edu	37	3	52800230	52800230	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:52800230G>A	uc003dfq.3	-	3	711	c.522C>T	c.(520-522)AGC>AGT	p.S174S	NEK4_uc011bej.1_Silent_p.S85S|NEK4_uc003dfr.2_Silent_p.S174S	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	174	Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		ACAATTCAGGGCTCATGTAGT	0.463													22	4					0	0	0.00106085	0	0
CACNA1D	776	broad.mit.edu	37	3	53760973	53760973	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:53760973C>T	uc003dgv.3	+	15	2331	c.2168C>T	c.(2167-2169)TCT>TTT	p.S723F	CACNA1D_uc003dgu.3_Missense_Mutation_p.S743F|CACNA1D_uc003dgy.3_Missense_Mutation_p.S723F|CACNA1D_uc003dgw.3_Missense_Mutation_p.S390F	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	723	Extracellular (Potential).|II.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGCCCATCCTCTTCAGGAATG	0.502													105	17					0	0	0.000781405	0	0
CHDH	55349	broad.mit.edu	37	3	53852986	53852986	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:53852986G>A	uc003dgz.2	-	8	1785	c.1345C>T	c.(1345-1347)CAG>TAG	p.Q449*		NM_018397	NP_060867	Q8NE62	CHDH_HUMAN	choline dehydrogenase precursor	449					alcohol metabolic process		choline dehydrogenase activity|flavin adenine dinucleotide binding			ovary(1)|central_nervous_system(1)	2		Hepatocellular(537;0.152)		BRCA - Breast invasive adenocarcinoma(193;0.000158)|KIRC - Kidney renal clear cell carcinoma(284;0.00588)|Kidney(284;0.00673)|OV - Ovarian serous cystadenocarcinoma(275;0.118)	Choline(DB00122)	TAGTTGGGCTGGATCACAGGG	0.527													38	7					0	0	0.00170553	0	0
FLNB	2317	broad.mit.edu	37	3	58154221	58154221	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:58154221C>T	uc003djj.2	+	44	7418	c.7253C>T	c.(7252-7254)TCC>TTC	p.S2418F	FLNB_uc010hne.2_Missense_Mutation_p.S2449F|FLNB_uc003djk.2_Missense_Mutation_p.S2407F|FLNB_uc010hnf.2_Missense_Mutation_p.S2394F|FLNB_uc003djl.2_Missense_Mutation_p.S2238F|FLNB_uc003djm.2_Missense_Mutation_p.S2225F|uc003djn.2_Intron	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2418	Filamin 23.|Interaction with INPPL1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGGACATTATCCGTCACCATC	0.488													23	1					0	0	0.000878237	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64636740	64636741	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:64636740_64636741GG>TT	uc003dmg.2	-	9	1447_1448	c.1415_1416CC>AA	c.(1414-1416)CCC>CAA	p.P472Q	ADAMTS9_uc011bfo.1_Missense_Mutation_p.P444Q|ADAMTS9_uc003dmh.1_Missense_Mutation_p.P301Q|ADAMTS9_uc003dmk.1_Missense_Mutation_p.P472Q	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	472	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ACCACATCCAGGGGTTGGTGTA	0.406													11	466					0	0	6.4e-05	0	0
SUCLG2	8801	broad.mit.edu	37	3	67426209	67426209	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:67426209C>T	uc003dna.3	-	11	1286	c.1258G>A	c.(1258-1260)GAT>AAT	p.D420N	SUCLG2_uc010hob.2_Missense_Mutation_p.D167N	NM_003848	NP_003839	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming beta subunit	420					succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|skin(1)	2		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TTGGCTGCATCCTCCAGGTCA	0.502													17	6					0	0	0.00152264	0	0
MIR1324	100302212	broad.mit.edu	37	3	75679929	75679929	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:75679929G>A	hsa-mir-1324|MI0006657	+			c.16G>A																				0						AGAGGTGCATGAAGCCTGGTC	0.562													9	39					0	0	0.000978159	0	0
EPHA6	285220	broad.mit.edu	37	3	96706808	96706808	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:96706808G>A	uc010how.1	+	3	1128	c.1085G>A	c.(1084-1086)GGA>GAA	p.G362E	EPHA6_uc003drp.1_Missense_Mutation_p.G362E	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	267	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TGCAGTACAGGATATGAAGAA	0.348													31	53					0	0	0.001512	0	0
OR5H1	26341	broad.mit.edu	37	3	97852246	97852246	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:97852246G>A	uc011bgt.1	+	1	705	c.705G>A	c.(703-705)AGG>AGA	p.R235R		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						AAGGTGTAAGGAAAGCCTTTT	0.408													66	54					0	0	0.000781405	0	0
OR5H14	403273	broad.mit.edu	37	3	97868918	97868918	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:97868918C>T	uc003dsg.1	+	1	689	c.689C>T	c.(688-690)TCT>TTT	p.S230F		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AAAAAGAAGTCTGTCAAAGGT	0.378													24	25					0	0	0.00127121	0	0
HHLA2	11148	broad.mit.edu	37	3	108072538	108072538	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:108072538G>A	uc003dwy.3	+	4	496	c.329G>A	c.(328-330)AGA>AAA	p.R110K	HHLA2_uc011bhl.1_Missense_Mutation_p.R46K|HHLA2_uc010hpu.2_Missense_Mutation_p.R110K|HHLA2_uc003dwz.2_Missense_Mutation_p.R110K	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	110	Ig-like V-type 1.					integral to membrane				ovary(1)	1						TTTTTCAGAAGAGTAAGCCTT	0.423													39	35					0	0	0.00222228	0	0
RETNLB	84666	broad.mit.edu	37	3	108474705	108474705	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:108474705C>T	uc003dxh.2	-	3	354	c.256G>A	c.(256-258)GAT>AAT	p.D86N		NM_032579	NP_115968	Q9BQ08	RETNB_HUMAN	resistin like beta precursor	86					cell proliferation	extracellular region	hormone activity			skin(1)	1						AGCTGAACATCCCACGAACCA	0.572													31	37					0	0	0.00178596	0	0
MORC1	27136	broad.mit.edu	37	3	108698393	108698393	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:108698393C>T	uc003dxl.2	-	24	2533	c.2446G>A	c.(2446-2448)GAA>AAA	p.E816K	MORC1_uc011bhn.1_Missense_Mutation_p.E795K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	816					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTCACTGTTTCCTTGACAGGT	0.398													67	70					0	0	0.000781405	0	0
MORC1	27136	broad.mit.edu	37	3	108705748	108705748	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:108705748C>T	uc003dxl.2	-	22	2323	c.2236G>A	c.(2236-2238)GAA>AAA	p.E746K	MORC1_uc011bhn.1_Missense_Mutation_p.E725K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	746	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						AGAGGAATTTCCTTTTTTTCT	0.279													9	22					0	0	0.000442599	0	0
MORC1	27136	broad.mit.edu	37	3	108751625	108751625	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:108751625C>T	uc003dxl.2	-	16	1594	c.1507G>A	c.(1507-1509)GAA>AAA	p.E503K	MORC1_uc011bhn.1_Missense_Mutation_p.E503K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	503	CW-type.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						AATTCTTTTTCCTGATAATTA	0.289													40	37					0	0	0.000781405	0	0
MORC1	27136	broad.mit.edu	37	3	108813765	108813765	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:108813765C>T	uc003dxl.2	-	7	661	c.574G>A	c.(574-576)GGA>AGA	p.G192R	MORC1_uc011bhn.1_Missense_Mutation_p.G192R	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	192					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CCACATTTTCCATAGATCACA	0.308													19	20					0	0	0.00229938	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376574	113376574	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:113376574G>A	uc003eam.2	-	7	4366	c.3955C>T	c.(3955-3957)CCA>TCA	p.P1319S	KIAA2018_uc003eal.2_Missense_Mutation_p.P1263S	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	1319					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						TCATGGCTTGGCTTTAAGAGT	0.453													75	83					0	0	0.000781405	0	0
KIAA1407	57577	broad.mit.edu	37	3	113753875	113753875	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:113753875C>T	uc003eax.2	-	6	862	c.715G>A	c.(715-717)GCT>ACT	p.A239T	KIAA1407_uc011bin.1_RNA|KIAA1407_uc011bio.1_Missense_Mutation_p.A217T|KIAA1407_uc011bip.1_Missense_Mutation_p.A226T	NM_020817	NP_065868	Q8NCU4	K1407_HUMAN	hypothetical protein LOC57577	239	Potential.									ovary(2)	2						GCCTCCAGAGCCTTCCTTTTC	0.483													65	77					0	0	0.000781405	0	0
C3orf15	89876	broad.mit.edu	37	3	119434558	119434558	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:119434558C>T	uc003ede.3	+	6	727	c.650C>T	c.(649-651)CCT>CTT	p.P217L	C3orf15_uc003edc.2_Missense_Mutation_p.P217L|C3orf15_uc010hqy.1_Missense_Mutation_p.P217L|C3orf15_uc010hqz.2_Missense_Mutation_p.P155L|C3orf15_uc011bjd.1_Missense_Mutation_p.P91L|C3orf15_uc011bje.1_Missense_Mutation_p.P197L|C3orf15_uc010hra.1_5'UTR	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	217						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GACTCAATCCCTGAGCTCTTG	0.473													36	29					0	0	0.00111076	0	0
FSTL1	11167	broad.mit.edu	37	3	120123744	120123744	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:120123744G>A	uc003eds.2	-	7	712	c.537C>T	c.(535-537)ATC>ATT	p.I179I	FSTL1_uc011bjh.1_Silent_p.I144I	NM_007085	NP_009016	Q12841	FSTL1_HUMAN	follistatin-like 1 precursor	179					BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.189)		TTGTAATATTGATGGCAGTTT	0.443													63	120					0	0	0.000781405	0	0
RABL3	285282	broad.mit.edu	37	3	120424922	120424922	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:120424922G>A	uc003edx.2	-	4	338	c.308C>T	c.(307-309)TCC>TTC	p.S103F		NM_173825	NP_776186	Q5HYI8	RABL3_HUMAN	RAB, member of RAS oncogene family-like 3	103	Small GTPase-like.				small GTPase mediated signal transduction		GTP binding				0				GBM - Glioblastoma multiforme(114;0.151)		CAAGTTTTGGGAGGACTTCTT	0.388													61	61					0	0	0.000781405	0	0
STXBP5L	9515	broad.mit.edu	37	3	120941855	120941855	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:120941855C>T	uc003eec.3	+	11	1102	c.962C>T	c.(961-963)CCA>CTA	p.P321L	STXBP5L_uc011bji.1_Missense_Mutation_p.P321L	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	321	WD 6.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TGTAGCGAACCATTCATAATA	0.373													40	82					0	0	0.00195071	0	0
STXBP5L	9515	broad.mit.edu	37	3	120976108	120976108	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:120976108C>T	uc003eec.3	+	17	1900	c.1760C>T	c.(1759-1761)TCA>TTA	p.S587L	STXBP5L_uc011bji.1_Missense_Mutation_p.S587L	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	587	WD 9.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		CTTCCTTCTTCAAGGAGTCTT	0.418													54	63					0	0	0.000781405	0	0
SEMA5B	54437	broad.mit.edu	37	3	122667507	122667507	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:122667507G>A	uc003efz.1	-	3	478	c.174C>T	c.(172-174)ATC>ATT	p.I58I	SEMA5B_uc011bju.1_5'UTR|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Silent_p.I58I|SEMA5B_uc010hro.1_5'UTR|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	58	Extracellular (Potential).				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CAAGCACCATGATAGGCCCCT	0.627													17	30					0	0	0.000566183	0	0
MYLK	4638	broad.mit.edu	37	3	123419583	123419583	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:123419583G>A	uc003ego.2	-	18	3014	c.2732C>T	c.(2731-2733)TCG>TTG	p.S911L	MYLK_uc011bjw.1_Missense_Mutation_p.S911L|MYLK_uc003egp.2_Missense_Mutation_p.S842L|MYLK_uc003egq.2_Missense_Mutation_p.S911L|MYLK_uc003egr.2_Missense_Mutation_p.S842L|MYLK_uc003egs.2_Missense_Mutation_p.S735L|MYLK_uc003egt.2_Missense_Mutation_p.S102L	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	911	1-2.|5 X 28 AA approximate tandem repeats.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		GTCGTCTTCCGATAGGGTCTT	0.582													59	43					0	0	0.000781405	0	0
KALRN	8997	broad.mit.edu	37	3	124416491	124416492	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:124416491_124416492CC>TT	uc003ehg.2	+	55	7878_7879	c.7751_7752CC>TT	c.(7750-7752)TCC>TTT	p.S2584F	KALRN_uc003ehk.2_Missense_Mutation_p.S887F	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2583	Fibronectin type-III.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						AGCTGCACCTCCGTGATTCTCC	0.545													7	12					0	0	6.4e-05	0	0
SLC12A8	84561	broad.mit.edu	37	3	124906250	124906251	+	Missense_Mutation	DNP	CC	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:124906250_124906251CC>AT	uc003ehv.3	-	4	331_332	c.220_221GG>AT	c.(220-222)GGC>ATC	p.G74I	SLC12A8_uc003ehw.3_Missense_Mutation_p.G103I|SLC12A8_uc010hrz.1_5'UTR	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	74	Helical; (Potential).				potassium ion transport	integral to membrane	symporter activity				0						CAGGAACATGCCCAGGAGCACT	0.629													17	20					0	0	6.4e-05	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125844543	125844543	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:125844543G>A	uc003eim.1	-	15	1906	c.1716C>T	c.(1714-1716)CCC>CCT	p.P572P	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.P471P	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	572	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GATAGTTCCAGGGGATGATGA	0.577													26	34					0	0	0.000720815	0	0
TPRA1	131601	broad.mit.edu	37	3	127294631	127294631	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:127294631G>A	uc003ejl.2	-	7	922	c.631C>T	c.(631-633)CTT>TTT	p.L211F	TPRA1_uc003ejm.2_Intron|TPRA1_uc003ejo.2_Missense_Mutation_p.L211F|TPRA1_uc010hsk.2_Intron|TPRA1_uc003ejn.2_Missense_Mutation_p.L211F	NM_016372	NP_057456	Q86W33	TPRA1_HUMAN	G protein-coupled receptor 175 isoform 1	211	Helical; Name=5; (Potential).				aging|lipid metabolic process	integral to membrane	G-protein coupled receptor activity				0						GTCTTGGGAAGGATGACCACC	0.647													34	48					0	0	0.00195071	0	0
EEFSEC	60678	broad.mit.edu	37	3	127980974	127980974	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:127980974C>T	uc003eki.2	+	3	566	c.528C>T	c.(526-528)TTC>TTT	p.F176F	EEFSEC_uc003ekj.2_Silent_p.F176F	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	176						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						ATTTCAGGTTCCGAGGTGCAC	0.542													63	95					0	0	0.000781405	0	0
EEFSEC	60678	broad.mit.edu	37	3	128060522	128060522	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:128060522G>A	uc003eki.2	+	5	1271	c.1233G>A	c.(1231-1233)TGG>TGA	p.W411*	EEFSEC_uc003ekj.2_Nonsense_Mutation_p.W356*	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	411						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GGCAGCAGTGGGCCCTGGTGG	0.602													37	38					0	0	0.00111076	0	0
GP9	2815	broad.mit.edu	37	3	128780669	128780669	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:128780669G>A	uc003elm.2	+	3	274	c.87G>A	c.(85-87)CTG>CTA	p.L29L		NM_000174	NP_000165	P14770	GPIX_HUMAN	glycoprotein IX (platelet) precursor	29	Extracellular (Potential).|LRRNT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding				0					Quinine(DB00468)	GCCGCGCCCTGGAAACCATGG	0.701													9	10					0	0	0.000442599	0	0
PLXND1	23129	broad.mit.edu	37	3	129276010	129276010	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:129276010G>A	uc003emx.2	-	34	5602	c.5502C>T	c.(5500-5502)ATC>ATT	p.I1834I	PLXND1_uc003emw.2_5'UTR|PLXND1_uc011blb.1_Silent_p.I503I	NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1834	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AGCGCTGCACGATCTTCCGGT	0.587													36	51					0	0	0.00148497	0	0
COL29A1	256076	broad.mit.edu	37	3	130159661	130159661	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:130159661C>T	uc010htj.1	+	35	6973	c.6479C>T	c.(6478-6480)TCG>TTG	p.S2160L	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.S199L	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	2160	Nonhelical region.				axon guidance|cell adhesion	collagen					0						TTTTTATACTCGGTCAGGCGT	0.323													11	17					0	0	0.00136819	0	0
COL29A1	256076	broad.mit.edu	37	3	130188260	130188260	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:130188260G>A	uc010htj.1	+	38	7906	c.7412G>A	c.(7411-7413)CGA>CAA	p.R2471Q	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.R510Q	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	2471	VWFA 10.|Nonhelical region.				axon guidance|cell adhesion	collagen					0						CAACTTGGCCGAACCCACAAG	0.393													31	21					0	0	0.0024448	0	0
COL6A6	131873	broad.mit.edu	37	3	130300434	130300434	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:130300434G>A	uc010htl.2	+	8	3608	c.3577G>A	c.(3577-3579)GAT>AAT	p.D1193N	COL6A6_uc003eni.3_5'Flank	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1193	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GGTGGGATTTGATGTCTCAAC	0.438													56	85					0	0	0.000781405	0	0
CPNE4	131034	broad.mit.edu	37	3	131404763	131404763	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:131404763G>A	uc003eok.2	-	6	982	c.547C>T	c.(547-549)CGT>TGT	p.R183C	CPNE4_uc011blq.1_Missense_Mutation_p.R201C|CPNE4_uc003eol.2_Missense_Mutation_p.R201C|CPNE4_uc003eom.2_Missense_Mutation_p.R183C	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	183	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TCATTCATACGAAAAATTTCC	0.383													11	28					0	0	0.00136819	0	0
BFSP2	8419	broad.mit.edu	37	3	133166238	133166238	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:133166238A>G	uc003epn.1	+	2	705	c.567A>G	c.(565-567)AAA>AAG	p.K189K	uc003epo.2_Intron	NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	189	Rod.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						ATGACTTTAAAGAGAGGTAAT	0.517													8	35					0	0	0.000157383	0	0
EPHB1	2047	broad.mit.edu	37	3	134885813	134885813	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:134885813A>T	uc003eqt.2	+	9	1944	c.1724A>T	c.(1723-1725)TAC>TTC	p.Y575F	EPHB1_uc003equ.2_Missense_Mutation_p.Y136F	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	575	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GAGGCTGTGTACAGCGATAAG	0.547													46	160					0	0	0.000781405	0	0
MRAS	22808	broad.mit.edu	37	3	138116224	138116225	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:138116224_138116225GG>TT	uc003esh.3	+	3	813_814	c.252_253GG>TT	c.(250-255)ACGGGG>ACTTGG	p.G85W	MRAS_uc011bmi.1_Missense_Mutation_p.G9W|MRAS_uc003esi.3_Missense_Mutation_p.G85W|MRAS_uc011bmj.1_Missense_Mutation_p.G9W	NM_012219	NP_036351	O14807	RASM_HUMAN	muscle RAS oncogene homolog precursor	85					actin cytoskeleton organization|muscle organ development|Ras protein signal transduction	intracellular|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						ACATGCGCACGGGGGATGGCTT	0.604													13	471					0	0	6.4e-05	0	0
FAIM	55179	broad.mit.edu	37	3	138341065	138341065	+	Silent	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:138341065G>T	uc003esr.2	+	3	407	c.147G>T	c.(145-147)GTG>GTT	p.V49V	FAIM_uc003eso.1_Silent_p.V83V|FAIM_uc003esp.2_Silent_p.V83V|FAIM_uc003esq.2_Silent_p.V71V|FAIM_uc003ess.2_Silent_p.V49V	NM_001033032	NP_001028204	Q9NVQ4	FAIM1_HUMAN	Fas apoptotic inhibitory molecule isoform c	49					apoptosis	cytoplasm					0						TCAAATTAGTGGGCAAAGAAA	0.299													12	396					0.00136819	0.00462231	0.00136819	1	0
RBP2	5948	broad.mit.edu	37	3	139181108	139181108	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:139181108A>G	uc003eth.2	-	2	149	c.98T>C	c.(97-99)ATT>ACT	p.I33T		NM_004164	NP_004155	P50120	RET2_HUMAN	retinol binding protein 2, cellular	33					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			skin(1)	1					Vitamin A(DB00162)	ACGTACTGCAATCTTGCGGGT	0.418													50	51					0	0	0.000781405	0	0
NMNAT3	349565	broad.mit.edu	37	3	139297845	139297845	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:139297845C>T	uc003etj.2	-	2	202	c.162G>A	c.(160-162)GGG>GGA	p.G54G	NMNAT3_uc003etk.2_Silent_p.G17G|NMNAT3_uc003etl.2_RNA|NMNAT3_uc010hul.2_Intron	NM_178177	NP_835471	Q96T66	NMNA3_HUMAN	nicotinamide mononucleotide adenylyltransferase	54					water-soluble vitamin metabolic process	cytosol|mitochondrion	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity				0						GGTCTTTCTTCCCATAGGTGT	0.567													19	23					0	0	0.00229938	0	0
SLC25A36	55186	broad.mit.edu	37	3	140695236	140695236	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:140695236C>T	uc003etr.2	+	7	1112	c.877C>T	c.(877-879)CCA>TCA	p.P293S	SLC25A36_uc003ets.2_Missense_Mutation_p.P292S|SLC25A36_uc003etq.2_Missense_Mutation_p.P136S|SLC25A36_uc011bmz.1_Missense_Mutation_p.P267S	NM_001104647	NP_001098117	Q96CQ1	S2536_HUMAN	solute carrier family 25, member 36 isoform a	293	Solcar 3.|Helical; Name=6; (Potential).				response to estradiol stimulus|transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0						GAGACAGATTCCAAACACAGC	0.398													46	49					0	0	0.000781405	0	0
SLC9A9	285195	broad.mit.edu	37	3	143550971	143550971	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:143550971G>A	uc003evn.2	-	2	450	c.268C>T	c.(268-270)CCA>TCA	p.P90S	SLC9A9_uc011bnk.1_Intron	NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	90					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						AGAGTTGATGGACTGAAAGTT	0.338													46	66					0	0	0.000781405	0	0
CPB1	1360	broad.mit.edu	37	3	148559645	148559645	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:148559645C>T	uc003ewl.2	+	6	533	c.510C>T	c.(508-510)TTC>TTT	p.F170F		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	170					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTGCCATTTTCATGGACTGTG	0.438													75	78					0	0	0.000781405	0	0
MBNL1	4154	broad.mit.edu	37	3	152150596	152150596	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:152150596C>T	uc003ezm.2	+	3	1225	c.436C>T	c.(436-438)CCG>TCG	p.P146S	MBNL1_uc003ezh.2_Missense_Mutation_p.P146S|MBNL1_uc003ezi.2_Missense_Mutation_p.P146S|MBNL1_uc003ezj.2_Missense_Mutation_p.P89S|MBNL1_uc003ezl.2_Missense_Mutation_p.P146S|MBNL1_uc003ezp.2_Missense_Mutation_p.P146S|MBNL1_uc003ezn.2_Intron|MBNL1_uc003ezo.2_Intron|MBNL1_uc010hvp.2_Missense_Mutation_p.P54S	NM_207293	NP_997176	Q9NR56	MBNL1_HUMAN	muscleblind-like 1 isoform c	146					embryonic limb morphogenesis|in utero embryonic development|myoblast differentiation|nervous system development	nucleus|stress granule	double-stranded RNA binding|protein binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			AAGCCTGGTCCCGGCAGAGAT	0.517													111	132					0	0	0.000781405	0	0
PLCH1	23007	broad.mit.edu	37	3	155203476	155203476	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:155203476C>T	uc011bok.1	-	22	2944	c.2667G>A	c.(2665-2667)AAG>AAA	p.K889K	PLCH1_uc011boj.1_Silent_p.K889K|PLCH1_uc011bol.1_Silent_p.K851K	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	889					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TGAACAGTCCCTTCAGACCCT	0.433													19	17					0	0	0.00188189	0	0
LEKR1	389170	broad.mit.edu	37	3	156710923	156710923	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:156710923A>T	uc003fba.1	+	10	1389	c.54A>T	c.(52-54)AAA>AAT	p.K18N		NM_001004316	NP_001004316	Q6ZMV7	LEKR1_HUMAN	leucine, glutamate and lysine rich 1	38											0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			AGATATATAAAGCATTACAGG	0.338													44	68					0	0	0.0025221	0	0
SI	6476	broad.mit.edu	37	3	164716332	164716332	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:164716332G>A	uc003fei.2	-	38	4598	c.4536C>T	c.(4534-4536)ATC>ATT	p.I1512I		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1512	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACTTACCAATGATTGATTTGT	0.393										HNSCC(35;0.089)			38	45					0	0	0.00128727	0	0
SI	6476	broad.mit.edu	37	3	164724636	164724636	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:164724636G>A	uc003fei.2	-	37	4436	c.4374C>T	c.(4372-4374)CTC>CTT	p.L1458L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1458	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACCATCCATAGAGATTGTGAA	0.348										HNSCC(35;0.089)			26	27					0	0	0.000878237	0	0
ZBBX	79740	broad.mit.edu	37	3	167000104	167000104	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:167000104G>A	uc003fep.2	-	19	2382	c.2059C>T	c.(2059-2061)CTT>TTT	p.L687F	ZBBX_uc011bpc.1_Missense_Mutation_p.L726F|ZBBX_uc003feq.2_Missense_Mutation_p.L658F	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	687						intracellular	zinc ion binding			ovary(2)	2						TCTAAGGAAAGCTCATTCTGG	0.353													38	42					0	0	0.000692331	0	0
SERPINI2	5276	broad.mit.edu	37	3	167189520	167189520	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:167189520G>A	uc003fer.1	-	1	161	c.103C>T	c.(103-105)CAA>TAA	p.Q35*	SERPINI2_uc003fes.1_Nonsense_Mutation_p.Q45*|SERPINI2_uc003fet.1_Nonsense_Mutation_p.Q35*	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	35					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						GAAACCTCTTGATAAAGATCC	0.393													92	89					0	0	0.000781405	0	0
SAMD7	344658	broad.mit.edu	37	3	169644746	169644746	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:169644746C>T	uc003fgd.2	+	6	963	c.696C>T	c.(694-696)CCC>CCT	p.P232P	SAMD7_uc003fge.2_Silent_p.P232P|SAMD7_uc011bpo.1_Silent_p.P133P	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	232										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TTGAAGCACCCAGCAACCAGA	0.483													18	51					0	0	0.00074312	0	0
SAMD7	344658	broad.mit.edu	37	3	169644765	169644765	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:169644765G>A	uc003fgd.2	+	6	982	c.715G>A	c.(715-717)GAA>AAA	p.E239K	SAMD7_uc003fge.2_Missense_Mutation_p.E239K|SAMD7_uc011bpo.1_Missense_Mutation_p.E140K	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	239										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GAAGTCAAGTGAAACGAATGA	0.493													22	50					0	0	0.00278032	0	0
SAMD7	344658	broad.mit.edu	37	3	169656227	169656227	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:169656227T>A	uc003fgd.2	+	9	1541	c.1274T>A	c.(1273-1275)ATG>AAG	p.M425K	SAMD7_uc003fge.2_Missense_Mutation_p.M425K|SAMD7_uc011bpo.1_Missense_Mutation_p.M326K	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	425										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			AGTGATACAATGAACATTTTT	0.388													26	35					0	0	0.000878237	0	0
SLC7A14	57709	broad.mit.edu	37	3	170201138	170201138	+	Silent	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:170201138G>T	uc003fgz.2	-	6	1396	c.1080C>A	c.(1078-1080)GTC>GTA	p.V360V	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	360	Helical; (Potential).					integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TGGCATAAATGACCCTCGGCA	0.547											OREG0015917	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	76					9.17885e-22	3.15917e-21	0.00058488	1	0
PLD1	5337	broad.mit.edu	37	3	171405331	171405331	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:171405331T>C	uc003fhs.2	-	15	1699	c.1583A>G	c.(1582-1584)AAA>AGA	p.K528R	PLD1_uc003fht.2_Missense_Mutation_p.K528R	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	528	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	AGGCTCATTTTTATCTTTGAG	0.368													46	68					0	0	0.000781405	0	0
FNDC3B	64778	broad.mit.edu	37	3	172016555	172016555	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:172016555C>T	uc003fhy.2	+	9	1211	c.1039C>T	c.(1039-1041)CCA>TCA	p.P347S	FNDC3B_uc003fhz.3_Missense_Mutation_p.P347S|FNDC3B_uc003fia.2_Missense_Mutation_p.P278S	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	347	Fibronectin type-III 1.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		AGATCTTAGACCAGCAACAGA	0.358													37	81					0	0	0.00222228	0	0
ECT2	1894	broad.mit.edu	37	3	172482202	172482202	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:172482202C>T	uc003fii.2	+	11	1248	c.1110C>T	c.(1108-1110)CCC>CCT	p.P370P	ECT2_uc010hwv.1_Silent_p.P401P|ECT2_uc003fih.2_Silent_p.P369P|ECT2_uc003fij.1_Silent_p.P370P|ECT2_uc003fik.1_Silent_p.P370P|ECT2_uc003fil.1_Silent_p.P401P	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	370					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CATTTCCACCCCGTAAGCGCC	0.453													33	53					0	0	0.00283554	0	0
MCF2L2	23101	broad.mit.edu	37	3	182897272	182897272	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:182897272C>T	uc003fli.1	-	30	3331	c.3241G>A	c.(3241-3243)GAG>AAG	p.E1081K		NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	1081					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GCGCGCTCCTCCTCGGTGCTG	0.687													12	9					0	0	0.000978159	0	0
PARL	55486	broad.mit.edu	37	3	183547481	183547481	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:183547481C>A	uc003fmd.2	-	10	1104	c.1045G>T	c.(1045-1047)GGT>TGT	p.G349C	PARL_uc003fme.2_Missense_Mutation_p.G299C	NM_018622	NP_061092	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like isoform 1	349	Helical; (Potential).				proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGTTCATGACCGTAAGTAACA	0.428													6	216					0.00198382	0.00668814	0.00198382	1	0
DGKG	1608	broad.mit.edu	37	3	186024722	186024722	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:186024722C>T	uc003fqa.2	-	3	649	c.112G>A	c.(112-114)GGT>AGT	p.G38S	DGKG_uc003fqb.2_Missense_Mutation_p.G38S|DGKG_uc003fqc.2_Missense_Mutation_p.G38S|DGKG_uc011brx.1_Missense_Mutation_p.G38S	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	38					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity	p.G38S(1)		breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AGGCTCCCACCCTCATTAAAT	0.393													42	52					0	0	0.000781405	0	0
LPP	4026	broad.mit.edu	37	3	188584049	188584050	+	Missense_Mutation	DNP	CC	TT	TT	rs138205223	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:188584049_188584050CC>TT	uc003frs.1	+	9	1718_1719	c.1472_1473CC>TT	c.(1471-1473)ACC>ATT	p.T491I	LPP_uc011bsg.1_Missense_Mutation_p.T344I|LPP_uc011bsi.1_Missense_Mutation_p.T491I|LPP_uc011bsj.1_Missense_Mutation_p.T328I	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	491	LIM zinc-binding 2.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CTCCGAGCCACCGGGAAGGCCT	0.559			T	HMGA2|MLL|C12orf9	lipoma|leukemia								43	62					0	0	6.4e-05	0	0
TPRG1	285386	broad.mit.edu	37	3	188933083	188933083	+	Silent	SNP	G	A	A	rs141310543		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:188933083G>A	uc003frv.1	+	8	1440	c.213G>A	c.(211-213)CCG>CCA	p.P71P	TPRG1_uc003frw.1_Silent_p.P71P	NM_198485	NP_940887	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	71											0	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		CCACACAGCCGGGGGCCATTG	0.488													32	51					0	0	0.00058488	0	0
ATP13A5	344905	broad.mit.edu	37	3	193019069	193019069	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:193019069G>A	uc011bsq.1	-	24	2706	c.2706C>T	c.(2704-2706)TCC>TCT	p.S902S		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	902					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ATACTCCAAAGGATGAAACCA	0.323													95	152					0	0	0.000781405	0	0
ATP13A4	84239	broad.mit.edu	37	3	193175222	193175222	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:193175222G>A	uc003ftd.2	-	15	1815	c.1707C>T	c.(1705-1707)ATC>ATT	p.I569I	ATP13A4_uc003fte.1_Silent_p.I569I|ATP13A4_uc011bsr.1_Silent_p.I40I|ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	569	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GCACTCCCTTGATGTGGAAAT	0.463													81	88					0	0	0.000781405	0	0
APOD	347	broad.mit.edu	37	3	195295875	195295875	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:195295875G>A	uc003fur.2	-	5	828	c.466C>T	c.(466-468)CCT>TCT	p.P156S		NM_001647	NP_001638	P05090	APOD_HUMAN	apolipoprotein D precursor	156					lipid metabolic process	extracellular space	lipid binding|lipid transporter activity|protein binding			ovary(2)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		GTTTCTGGAGGGAGATTAGGG	0.443													61	65					0	0	0.000781405	0	0
MUC4	4585	broad.mit.edu	37	3	195517616	195517616	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:195517616C>T	uc011bto.1	-	2	1295	c.835G>A	c.(835-837)GAG>AAG	p.E279K	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.E161K	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	284					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GATGATGTCTCCCCTGGGTTT	0.468													52	39					0	0	0.000781405	0	0
PDE6B	5158	broad.mit.edu	37	4	619505	619505	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:619505G>A	uc003gap.2	+	1	143	c.90G>A	c.(88-90)GAG>GAA	p.E30E	PDE6B_uc003gao.3_Silent_p.E30E	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	30					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						TGAGCCCTGAGAATGTGGCCG	0.502													22	21					0	0	0.00278032	0	0
DGKQ	1609	broad.mit.edu	37	4	956341	956341	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:956341G>A	uc003gbw.2	-	18	2170	c.2096C>T	c.(2095-2097)TCC>TTC	p.S699F	DGKQ_uc010ibn.2_Missense_Mutation_p.S686F	NM_001347	NP_001338	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta	699	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding			kidney(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CAGCAGTACGGAGAACGGGTC	0.647													17	17					0	0	0.00121646	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018188	1018188	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:1018188G>A	uc003gce.2	+	6	969	c.808G>A	c.(808-810)GTG>ATG	p.V270M	FGFRL1_uc003gcf.2_Missense_Mutation_p.V270M|FGFRL1_uc003gcg.2_Missense_Mutation_p.V270M|FGFRL1_uc010ibo.2_Missense_Mutation_p.V270M	NM_021923	NP_068742	Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	270	Ig-like C2-type 3.|Extracellular (Potential).				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CCAGTGCAAGGTGCGCAGCGA	0.662													17	35					0	0	0.00152264	0	0
SPON2	10417	broad.mit.edu	37	4	1165760	1165760	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:1165760T>C	uc003gcn.3	-	1	127	c.100A>G	c.(100-102)ATC>GTC	p.I34V	SPON2_uc003gco.3_Missense_Mutation_p.I34V|SPON2_uc010ibr.2_Missense_Mutation_p.I34V|SPON2_uc003gcm.1_5'Flank	NM_012445	NP_036577	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	34	Spondin.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		GCGGAACAGATGGACTCTCCC	0.687													19	33					0	0	0.00229938	0	0
HTT	3064	broad.mit.edu	37	4	3189409	3189409	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:3189409C>T	uc011bvq.1	+	40	5172	c.5027C>T	c.(5026-5028)TCG>TTG	p.S1676L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1674					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CTGTGGATATCGGGAATTCTG	0.403													45	61					0	0	0.000781405	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6081952	6081952	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:6081952A>G	uc003giu.3	-	7	1465	c.1189T>C	c.(1189-1191)TTC>CTC	p.F397L	JAKMIP1_uc010idb.1_Missense_Mutation_p.F397L|JAKMIP1_uc010idc.1_Missense_Mutation_p.F232L|JAKMIP1_uc010idd.1_Missense_Mutation_p.F397L|JAKMIP1_uc011bwc.1_Missense_Mutation_p.F232L|JAKMIP1_uc003giv.3_Missense_Mutation_p.F397L|JAKMIP1_uc010ide.2_Missense_Mutation_p.F397L	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	397	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						AGCCTCAGGAACTCGATCTCC	0.607													15	13					0	0	0.000308642	0	0
KIAA0232	9778	broad.mit.edu	37	4	6865634	6865634	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:6865634C>T	uc003gjr.3	+	7	3988	c.3525C>T	c.(3523-3525)TTC>TTT	p.F1175F	KIAA0232_uc003gjq.3_Silent_p.F1175F	NM_014743	NP_055558	Q92628	K0232_HUMAN	hypothetical protein LOC9778	1175							ATP binding			ovary(2)	2						CTGGAAAATTCCTTCCCAGGT	0.413													22	26					0	0	0.00047179	0	0
SORCS2	57537	broad.mit.edu	37	4	7741963	7741963	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:7741963G>A	uc003gkb.3	+	27	3452	c.3452G>A	c.(3451-3453)CGA>CAA	p.R1151Q	SORCS2_uc011bwi.1_Missense_Mutation_p.R994Q	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	1151	Cytoplasmic (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						ATCAACTCCCGAGAGATGCAC	0.617													8	6					0	0	0.000442599	0	0
ZNF518B	85460	broad.mit.edu	37	4	10447658	10447658	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:10447658G>A	uc003gmn.2	-	3	782	c.295C>T	c.(295-297)CAT>TAT	p.H99Y		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						CTCACAAAATGAAAATTGGGA	0.418													33	45					0	0	0.000953801	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401168	11401168	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:11401168T>C	uc003gmq.2	-	2	785	c.462A>G	c.(460-462)CTA>CTG	p.L154L		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	154	PAPS (By similarity).					Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						TGTAGTCAGATAGCACGCGCT	0.587													15	23					0	0	0.000308642	0	0
BOD1L	259282	broad.mit.edu	37	4	13603467	13603467	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:13603467C>T	uc003gmz.1	-	10	5174	c.5057G>A	c.(5056-5058)AGT>AAT	p.S1686N	BOD1L_uc010idr.1_Missense_Mutation_p.S1023N	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1686							DNA binding			ovary(5)|breast(1)	6						TGCTCCATCACTTTCAACTTC	0.418													96	130					0	0	0.000781405	0	0
BOD1L	259282	broad.mit.edu	37	4	13616171	13616171	+	Missense_Mutation	SNP	G	A	A	rs142892563		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:13616171G>A	uc003gmz.1	-	4	940	c.823C>T	c.(823-825)CCA>TCA	p.P275S	BOD1L_uc010idr.1_5'UTR|BOD1L_uc010ids.1_RNA	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	275							DNA binding			ovary(5)|breast(1)	6						TCAGACTTTGGGGCTGTTTCC	0.393													20	39					0	0	0.000586117	0	0
PCDH7	5099	broad.mit.edu	37	4	30732387	30732387	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:30732387C>T	uc003gsk.1	+	2	4195	c.3187C>T	c.(3187-3189)CCA>TCA	p.P1063S	PCDH7_uc011bxw.1_Intron|PCDH7_uc011bxx.1_Intron	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	1063	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GCGTCTACATCCATACATTAC	0.393													17	44					0	0	0.00152264	0	0
PTTG2	10744	broad.mit.edu	37	4	37962567	37962567	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:37962567C>T	uc011bye.1	+	1	512	c.512C>T	c.(511-513)TCT>TTT	p.S171F	TBC1D1_uc003gtb.2_Intron|TBC1D1_uc011byd.1_Intron|TBC1D1_uc010ifd.2_Intron	NM_006607	NP_006598	Q9NZH5	PTTG2_HUMAN	pituitary tumor-transforming 2	171	SH3-binding (By similarity).				chromosome organization|DNA metabolic process	cytoplasm|nucleus	SH3 domain binding				0						AAAATGCCCTCTCCACCATGG	0.488													80	91					0	0	0.000781405	0	0
TBC1D1	23216	broad.mit.edu	37	4	38051318	38051318	+	Missense_Mutation	SNP	C	T	T	rs150670938		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:38051318C>T	uc003gtb.2	+	11	2052	c.1709C>T	c.(1708-1710)TCC>TTC	p.S570F	TBC1D1_uc011byd.1_Missense_Mutation_p.S570F|TBC1D1_uc010ifd.2_Missense_Mutation_p.S317F|TBC1D1_uc011byf.1_Missense_Mutation_p.S441F	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	570						nucleus	Rab GTPase activator activity			ovary(1)	1						GAGGACCTGTCCAGTGACTCG	0.592													26	34					0	0	0.000878237	0	0
TLR10	81793	broad.mit.edu	37	4	38776112	38776112	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:38776112C>T	uc003gti.2	-	2	1479	c.1100G>A	c.(1099-1101)AGA>AAA	p.R367K	TLR10_uc003gtj.2_Missense_Mutation_p.R367K|TLR10_uc003gtk.2_Missense_Mutation_p.R367K	NM_030956	NP_112218	Q9BXR5	TLR10_HUMAN	toll-like receptor 10 precursor	367	LRR 9.|Extracellular (Potential).				inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane	transmembrane receptor activity			lung(1)|breast(1)	2						TTGGATAGTTCTTTTAAACAA	0.348													29	51					0	0	0.00127121	0	0
N4BP2	55728	broad.mit.edu	37	4	40104513	40104513	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:40104513C>T	uc003guy.3	+	4	1386	c.1048C>T	c.(1048-1050)CTC>TTC	p.L350F	N4BP2_uc010ifq.2_Missense_Mutation_p.L270F|N4BP2_uc010ifr.2_Missense_Mutation_p.L270F	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	350	Pro-rich.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						ACTTGCTCCTCTCCCATTGCT	0.507													14	38					0	0	0.000422831	0	0
N4BP2	55728	broad.mit.edu	37	4	40104811	40104812	+	Missense_Mutation	DNP	CG	GT	GT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:40104811_40104812CG>GT	uc003guy.3	+	4	1684_1685	c.1346_1347CG>GT	c.(1345-1347)CCG>CGT	p.P449R	N4BP2_uc010ifq.2_Missense_Mutation_p.P369R|N4BP2_uc010ifr.2_Missense_Mutation_p.P369R	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	449	ATP (Potential).					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						AGAGGTCTTCCGGGATCTGGAA	0.361													13	31					0	0	6.4e-05	0	0
RHOH	399	broad.mit.edu	37	4	40245440	40245440	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:40245440C>T	uc003guz.2	+	3	1158	c.434C>T	c.(433-435)GCC>GTC	p.A145V		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	145					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						GATGTCAGAGCCAAGGGCTAC	0.622													12	18					0	0	0.000978159	0	0
RBM47	54502	broad.mit.edu	37	4	40440409	40440409	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:40440409G>A	uc003gvc.2	-	4	1212	c.502C>T	c.(502-504)CTG>TTG	p.L168L	RBM47_uc003gvd.2_Silent_p.L168L|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.L130L|RBM47_uc003gvg.1_Silent_p.L168L	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	168	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						ATCTCCTCCAGGATTTCCTCG	0.642													32	50					0	0	0.000692331	0	0
RBM47	54502	broad.mit.edu	37	4	40440446	40440446	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:40440446G>A	uc003gvc.2	-	4	1175	c.465C>T	c.(463-465)ATC>ATT	p.I155I	RBM47_uc003gvd.2_Silent_p.I155I|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.I117I|RBM47_uc003gvg.1_Silent_p.I155I	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	155	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(3)	3						GGATCCCGCCGATGAAGAGGC	0.652													28	26					0	0	0.00127121	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648648	41648648	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:41648648G>A	uc003gvu.3	+	12	1457	c.1403G>A	c.(1402-1404)AGA>AAA	p.R468K	LIMCH1_uc003gvv.3_Missense_Mutation_p.R468K|LIMCH1_uc003gvw.3_Missense_Mutation_p.R468K|LIMCH1_uc003gvx.3_Missense_Mutation_p.R456K|LIMCH1_uc003gwe.3_Missense_Mutation_p.R468K|LIMCH1_uc003gvy.3_Missense_Mutation_p.R297K|LIMCH1_uc003gwa.3_Missense_Mutation_p.R309K|LIMCH1_uc003gvz.3_Missense_Mutation_p.R853K|LIMCH1_uc011byu.1_Missense_Mutation_p.R302K|LIMCH1_uc003gwc.3_Missense_Mutation_p.R314K|LIMCH1_uc003gwd.3_Missense_Mutation_p.R302K|LIMCH1_uc011byv.1_Missense_Mutation_p.R219K	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	468					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						ATTCTGGAAAGAAGCCATTCA	0.498													69	81					0	0	0.000781405	0	0
ATP8A1	10396	broad.mit.edu	37	4	42467036	42467036	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:42467036G>A	uc003gwr.2	-	26	2614	c.2382C>T	c.(2380-2382)GTC>GTT	p.V794V	ATP8A1_uc003gwq.2_Silent_p.V20V|ATP8A1_uc003gws.2_Silent_p.V779V	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	794	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	CAAGCGTTACGACTTTGACTT	0.413													17	31					0	0	0.00121646	0	0
GABRG1	2565	broad.mit.edu	37	4	46053484	46053484	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:46053484C>T	uc003gxb.2	-	8	1240	c.1088G>A	c.(1087-1089)GGA>GAA	p.G363E		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	363	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AGCAGTCTTTCCTTTTTGGTT	0.328													7	10					0	0	0.00198382	0	0
GABRA4	2557	broad.mit.edu	37	4	46930341	46930341	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:46930341G>A	uc003gxg.2	-	9	1705	c.1566C>T	c.(1564-1566)GCC>GCT	p.A522A		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	522	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGAGAATACGGGCATATTTGT	0.413													41	42					0	0	0.00148497	0	0
CWH43	80157	broad.mit.edu	37	4	49019273	49019273	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:49019273G>A	uc003gyv.2	+	9	1376	c.1194G>A	c.(1192-1194)TGG>TGA	p.W398*	CWH43_uc011bzl.1_Nonsense_Mutation_p.W371*	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	398	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						TAGTTCTGTGGCTGCTTGTTG	0.358													27	28					0	0	0.0024448	0	0
LRRC66	339977	broad.mit.edu	37	4	52883365	52883365	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:52883365G>A	uc003gzi.2	-	1	428	c.415C>T	c.(415-417)CAC>TAC	p.H139Y		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	139						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CTGCTTCTGTGGCGTTTCACC	0.428													66	40					0	0	0.000781405	0	0
PDGFRA	5156	broad.mit.edu	37	4	55155000	55155000	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:55155000T>C	uc003han.3	+	20	3040	c.2709T>C	c.(2707-2709)TCT>TCC	p.S903S	PDGFRA_uc003haa.2_Silent_p.S663S	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	903	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGGTGGATTCTACTTTCTACA	0.512			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			30	21					0	0	0.00178596	0	0
UGT2A3	79799	broad.mit.edu	37	4	69816923	69816923	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:69816923G>A	uc003hef.2	-	1	587	c.556C>T	c.(556-558)CCA>TCA	p.P186S	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	186	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						AGTGGAGCTGGAAGTTTCCCA	0.448													9	11					0	0	0.000274275	0	0
UGT2B10	7365	broad.mit.edu	37	4	69884051	69884051	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:69884051C>T	uc011cao.1	-	5	798	c.662G>A	c.(661-663)CGA>CAA	p.R221Q	UGT2B10_uc011can.1_Missense_Mutation_p.R137Q			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	258					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						CCAGGAGTTTCGCATAAGCCA	0.383													29	51					0	0	0.00106085	0	0
ODAM	54959	broad.mit.edu	37	4	71068511	71068511	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:71068511G>A	uc003hfc.2	+	9	704	c.687G>A	c.(685-687)GCG>GCA	p.A229A		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	229					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						AAAAAGAAGCGATCAACTTTA	0.388													7	20					0	0	0.00198382	0	0
SLC4A4	8671	broad.mit.edu	37	4	72306347	72306347	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:72306347C>T	uc003hfy.2	+	8	939	c.822C>T	c.(820-822)TTC>TTT	p.F274F	SLC4A4_uc010iic.2_Silent_p.F274F|SLC4A4_uc010iib.2_Silent_p.F274F|SLC4A4_uc003hfz.2_Silent_p.F274F|SLC4A4_uc003hgc.3_Silent_p.F230F|SLC4A4_uc003hga.2_Silent_p.F152F|SLC4A4_uc003hgb.3_Silent_p.F230F	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	274	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AGAATAAGTTCATGAAAAAAT	0.418													26	46					0	0	0.00106085	0	0
ART3	419	broad.mit.edu	37	4	77003040	77003040	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:77003040G>A	uc003hjo.2	+	3	252	c.133G>A	c.(133-135)GAC>AAC	p.D45N	ART3_uc003hji.2_Missense_Mutation_p.D45N|ART3_uc003hjj.2_Missense_Mutation_p.D45N|ART3_uc003hjk.2_Missense_Mutation_p.D45N|ART3_uc010ija.1_Missense_Mutation_p.D45N|ART3_uc003hjn.2_Missense_Mutation_p.D45N|ART3_uc003hjp.2_Intron|ART3_uc010ijb.2_Intron|ART3_uc003hjq.2_Intron|ART3_uc003hjr.2_Missense_Mutation_p.D15N|ART3_uc010ijc.2_Missense_Mutation_p.D15N|ART3_uc010ijd.2_Missense_Mutation_p.D15N	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	45					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GAAATGTACGGACAGGATGGA	0.388													49	52					0	0	0.000781405	0	0
CCDC158	339965	broad.mit.edu	37	4	77305440	77305440	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:77305440C>T	uc003hkb.3	-	5	680	c.527G>A	c.(526-528)CGA>CAA	p.R176Q	CCDC158_uc003hkd.2_Missense_Mutation_p.R176Q	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	176	Potential.									skin(3)|ovary(2)|pancreas(1)	6						CATCATTTTTCGTAGTTGCTC	0.398													39	43					0	0	0.0025221	0	0
FRAS1	80144	broad.mit.edu	37	4	79432514	79432514	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:79432514C>T	uc003hlb.2	+	64	10307	c.9867C>T	c.(9865-9867)CCC>CCT	p.P3289P	FRAS1_uc003hlc.1_Silent_p.P291P	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3284	Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGGGGACCCCCTTAAGGAGCA	0.547													24	39					0	0	0.000878237	0	0
GK2	2712	broad.mit.edu	37	4	80328367	80328367	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:80328367G>A	uc003hlu.2	-	1	1006	c.988C>T	c.(988-990)CGT>TGT	p.R330C		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	330					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						CTTAGCCAACGAATAACAGCA	0.428													29	33					0	0	0.0024448	0	0
GK2	2712	broad.mit.edu	37	4	80329126	80329126	+	Missense_Mutation	SNP	C	T	T	rs149134428		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:80329126C>T	uc003hlu.2	-	1	247	c.229G>A	c.(229-231)GAA>AAA	p.E77K		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	77					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						ATATTCAGTTCGTCAAGTTTC	0.418													33	36					0	0	0.0024448	0	0
BMP3	651	broad.mit.edu	37	4	81967491	81967491	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:81967491G>A	uc003hmg.3	+	2	1236	c.916G>A	c.(916-918)GAA>AAA	p.E306K		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	306					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						TCCTGGGGCAGAATACCAGTA	0.502													7	13					0	0	0.00198382	0	0
SCD5	79966	broad.mit.edu	37	4	83602042	83602042	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:83602042C>T	uc003hna.2	-	3	707	c.387G>A	c.(385-387)AGG>AGA	p.R129R	SCD5_uc003hnb.3_Silent_p.R129R	NM_001037582	NP_001032671	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5 isoform a	129					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				CTCGGTGGTCCCTGGACCACT	0.587													34	44					0	0	0.000814825	0	0
THAP9	79725	broad.mit.edu	37	4	83839111	83839111	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:83839111G>A	uc003hnt.2	+	5	1865	c.1746G>A	c.(1744-1746)GAG>GAA	p.E582E	THAP9_uc003hns.1_Silent_p.E438E|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Silent_p.E299E	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	582							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				TCAATGCTGAGAGCTTAAAAT	0.333													17	16					0	0	0.000566183	0	0
HPSE	10855	broad.mit.edu	37	4	84240599	84240600	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:84240599_84240600GG>AA	uc003hoj.3	-	3	495_496	c.396_397CC>TT	c.(394-399)ATCCCT>ATTTCT	p.P133S	HPSE_uc010ika.2_Missense_Mutation_p.P133S|HPSE_uc011ccq.1_RNA|HPSE_uc011ccr.1_RNA|HPSE_uc011ccs.1_5'UTR|HPSE_uc011cct.1_Missense_Mutation_p.P133S|HPSE_uc003hok.3_Missense_Mutation_p.P133S	NM_001098540	NP_001092010	Q9Y251	HPSE_HUMAN	heparanase precursor	133					carbohydrate metabolic process|cell adhesion|proteoglycan metabolic process	extracellular region|lysosomal membrane|nucleus	beta-glucuronidase activity|cation binding			ovary(1)	1		Hepatocellular(203;0.114)		COAD - Colon adenocarcinoma(81;0.141)	Heparin(DB01109)	ACATCAGGAGGGATGGATCCAT	0.426													18	36					0	0	6.4e-05	0	0
PTPN13	5783	broad.mit.edu	37	4	87724936	87724936	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:87724936G>A	uc003hpz.2	+	43	7060	c.6580G>A	c.(6580-6582)GGT>AGT	p.G2194S	PTPN13_uc003hpy.2_Missense_Mutation_p.G2199S|PTPN13_uc003hqa.2_Missense_Mutation_p.G2175S|PTPN13_uc003hqb.2_Missense_Mutation_p.G2003S|PTPN13_uc003hqc.1_Missense_Mutation_p.G560S	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	2194						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TAAATACACGGGTGCCAACTT	0.448													34	58					0	0	0.00283554	0	0
DSPP	1834	broad.mit.edu	37	4	88533886	88533886	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:88533886G>A	uc003hqu.2	+	4	668	c.548G>A	c.(547-549)GGA>GAA	p.G183E		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	183					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		CAAGAAGATGGACCTCAAGTA	0.408													21	22					0	0	0.00152264	0	0
IBSP	3381	broad.mit.edu	37	4	88731890	88731890	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:88731890T>C	uc003hqx.3	+	6	477	c.379T>C	c.(379-381)TTA>CTA	p.L127L		NM_004967	NP_004958	P21815	SIAL_HUMAN	integrin-binding sialoprotein precursor	127	Asp/Glu-rich (acidic).				biomineral tissue development|cell adhesion|ossification						0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		GTATACAGGGTTAGCTGCAAT	0.403													25	26					0	0	0.000878237	0	0
Unknown	0	broad.mit.edu	37	4	88814582	88814582	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:88814582G>A	uc010iko.1	+	4	1209	c.1209G>A	c.(1207-1209)GGG>GGA	p.G403G						SubName: Full=Heat shock protein 90kDa alpha (Cytosolic), class B member 1, isoform CRA_a; SubName: Full=cDNA, FLJ92550, Homo sapiens heat shock 90kDa protein 1, beta (HSPCB), mRNA;																		AGTTTGATGGGAAAAGCCTGG	0.498													9	9					0	0	0.000274275	0	0
TMSL3	7117	broad.mit.edu	37	4	91760114	91760114	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:91760114C>T	uc003hsy.2	-	1	156	c.75G>A	c.(73-75)GAG>GAA	p.E25E	FAM190A_uc003hsv.3_Intron|FAM190A_uc010ikv.2_Intron|FAM190A_uc003hsx.2_Intron	NM_183049	NP_898870			thymosin-like 3												0		all_cancers(2;6.48e-24)|all_epithelial(2;3.86e-25)|Colorectal(2;8.52e-12)|all_lung(2;3.73e-07)|Lung NSC(2;7.99e-07)|Renal(2;0.0243)|Hepatocellular(203;0.0411)		Epithelial(2;5.28e-11)|OV - Ovarian serous cystadenocarcinoma(123;8.9e-10)|all cancers(2;3.21e-09)|STAD - Stomach adenocarcinoma(1;0.0201)		GTGGATTTTTCTCTTGCGTCT	0.493													44	50					0	0	0.000781405	0	0
GRID2	2895	broad.mit.edu	37	4	93511296	93511296	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:93511296G>A	uc011cdt.1	+	2	361	c.103G>A	c.(103-105)GAA>AAA	p.E35K	GRID2_uc010ikx.2_Missense_Mutation_p.E35K|GRID2_uc011cdu.1_Missense_Mutation_p.E35K	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	35	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AATTTTTGATGAATCTGCCAA	0.368													20	21					0	0	0.00188189	0	0
GRID2	2895	broad.mit.edu	37	4	94006212	94006212	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:94006212C>T	uc011cdt.1	+	3	569	c.311C>T	c.(310-312)TCC>TTC	p.S104F	GRID2_uc010ikx.2_Missense_Mutation_p.S104F|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	104	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TCAGCAGGATCCCTCCAGTCT	0.537													18	19					0	0	0.00074312	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99273742	99273742	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:99273742T>C	uc003htx.3	+	4	541	c.351T>C	c.(349-351)TGT>TGC	p.C117C	RAP1GDS1_uc003htu.2_Silent_p.C117C|RAP1GDS1_uc003htw.3_Silent_p.C118C|RAP1GDS1_uc003htv.3_Silent_p.C118C|RAP1GDS1_uc003htz.3_Silent_p.C117C|RAP1GDS1_uc003hty.3_Silent_p.C118C|RAP1GDS1_uc003hua.3_Silent_p.C118C	NM_001100427	NP_001093897	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1 isoform	117	ARM 1.						binding|GTPase activator activity			ovary(1)|lung(1)|breast(1)	3				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GAAACATATGTTACGATAGCC	0.398			T	NUP98	T-ALL								7	17					0	0	0.00198382	0	0
ADH4	127	broad.mit.edu	37	4	100063877	100063877	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:100063877C>T	uc003hun.2	-	2	149	c.73G>A	c.(73-75)GAA>AAA	p.E25K	uc003hum.1_Intron|ADH4_uc011ced.1_Missense_Mutation_p.E44K	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	25					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	TCAACCTCTTCAATGCAAAGG	0.493													23	27					0	0	0.00106085	0	0
ADH1C	126	broad.mit.edu	37	4	100273819	100273819	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:100273819C>T	uc003huu.2	-	1	99	c.14G>A	c.(13-15)GGA>GAA	p.G5E		NM_000669	NP_000660	P00326	ADH1G_HUMAN	class I alcohol dehydrogenase, gamma subunit	5					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	GCTTACTTTTCCTGCTGTGCT	0.308									Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of				27	42					0	0	0.0024448	0	0
ADH7	131	broad.mit.edu	37	4	100349317	100349317	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:100349317G>A	uc003huv.1	-	4	409	c.310C>T	c.(310-312)CCT>TCT	p.P104S		NM_000673	NP_000664	P40394	ADH7_HUMAN	class IV alcohol dehydrogenase, mu or sigma	104					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			lung(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	AGAAAGAGAGGGATGACTTTG	0.358													35	55					0	0	0.00058488	0	0
NHEDC1	150159	broad.mit.edu	37	4	103832643	103832643	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:103832643A>C	uc003hww.2	-	8	1003	c.881T>G	c.(880-882)CTG>CGG	p.L294R	NHEDC1_uc003hwu.2_Missense_Mutation_p.L294R|NHEDC1_uc010ilm.2_Missense_Mutation_p.L61R|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_Missense_Mutation_p.L67R	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	294	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		TCCTGCCAGCAGACTAATACA	0.323													4	30					0	0	0.00116845	0	0
NHEDC1	150159	broad.mit.edu	37	4	103866440	103866440	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:103866440G>A	uc003hww.2	-	6	685	c.563C>T	c.(562-564)GCT>GTT	p.A188V	NHEDC1_uc003hwu.2_Missense_Mutation_p.A188V|NHEDC1_uc010ilm.2_Intron|NHEDC1_uc003hwv.2_Intron|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	188	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		TGGACCTACAGCCAATCTGAA	0.383													32	64					0	0	0.00128727	0	0
INTS12	57117	broad.mit.edu	37	4	106614568	106614568	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:106614568G>A	uc003hxw.2	-	5	643	c.385C>T	c.(385-387)CCC>TCC	p.P129S	INTS12_uc010ilr.2_Missense_Mutation_p.P129S	NM_020395	NP_065128	Q96CB8	INT12_HUMAN	integrator complex subunit 12	129					snRNA processing	integrator complex	protein binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(123;5.12e-07)		ACAGTAATGGGAGATGACTGT	0.418													73	99					0	0	0.000781405	0	0
PAPSS1	9061	broad.mit.edu	37	4	108552847	108552847	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:108552847G>A	uc003hyk.2	-	11	1760	c.1676C>T	c.(1675-1677)CCC>CTC	p.P559L		NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	559	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		AACTCGAAAGGGAACTATTTC	0.428													18	33					0	0	0.000958276	0	0
ENPEP	2028	broad.mit.edu	37	4	111397747	111397747	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:111397747C>T	uc003iab.3	+	1	519	c.177C>T	c.(175-177)CAC>CAT	p.H59H		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	59	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CTCCTTCCCACCTGCCTTCTT	0.632													33	45					0	0	0.000814825	0	0
PITX2	5308	broad.mit.edu	37	4	111539383	111539383	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:111539383C>T	uc003iad.2	-	5	1434	c.852G>A	c.(850-852)CTG>CTA	p.L284L	PITX2_uc003iac.2_Silent_p.L291L|PITX2_uc003iae.2_Silent_p.L238L|PITX2_uc010iml.2_Silent_p.L155L|PITX2_uc003iaf.2_Silent_p.L284L	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	284	OAR.				determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CTTTCAGTCTCAGGCTGGCCA	0.622													16	19					0	0	0.000308642	0	0
ANK2	287	broad.mit.edu	37	4	114275446	114275446	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:114275446C>T	uc003ibe.3	+	38	5772	c.5672C>T	c.(5671-5673)TCT>TTT	p.S1891F	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.S1906F	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1858	Repeat-rich region.|Repeat A; approximate.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAAAGGCACTCTCCTGTGTCA	0.473													45	48					0	0	0.000680045	0	0
ANK2	287	broad.mit.edu	37	4	114276414	114276414	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:114276414C>T	uc003ibe.3	+	38	6740	c.6640C>T	c.(6640-6642)CCG>TCG	p.P2214S	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.P2229S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2181					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGCCGGCTCTCCGTGTGGCAG	0.517													36	43					0	0	0.00128727	0	0
SYNPO2	171024	broad.mit.edu	37	4	119951458	119951458	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:119951458G>A	uc003icm.3	+	4	1724	c.1528G>A	c.(1528-1530)GAA>AAA	p.E510K	SYNPO2_uc010ina.2_Missense_Mutation_p.E510K|SYNPO2_uc010inb.2_Missense_Mutation_p.E510K|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.E438K	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	510						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						AGCCCAAAAAGAAGAGGACAA	0.522													8	13					0	0	0.000157383	0	0
KIAA1109	84162	broad.mit.edu	37	4	123161431	123161431	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:123161431C>T	uc003ieh.2	+	27	4639	c.4594C>T	c.(4594-4596)CGT>TGT	p.R1532C	KIAA1109_uc003iei.1_Missense_Mutation_p.R1285C|KIAA1109_uc010ins.1_Missense_Mutation_p.R875C|KIAA1109_uc003iek.2_Missense_Mutation_p.R151C	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1532					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTCATTGCATCGTCCCCTTGA	0.383													31	23					0	0	0.00209593	0	0
ADAD1	132612	broad.mit.edu	37	4	123342510	123342510	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:123342510G>A	uc003ieo.2	+	12	1814	c.1582G>A	c.(1582-1584)GAA>AAA	p.E528K	ADAD1_uc003iep.2_Missense_Mutation_p.E517K|ADAD1_uc003ieq.2_Missense_Mutation_p.E510K	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	528	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						AGCTAAAAAAGAATTACTTGA	0.353													19	33					0	0	0.00074312	0	0
SPATA5	166378	broad.mit.edu	37	4	124177183	124177183	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:124177183C>T	uc003iez.3	+	15	2426	c.2353C>T	c.(2353-2355)CCT>TCT	p.P785S		NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	785					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						TTTGATGCGGCCTGGAAGAAT	0.408													20	28					0	0	0.000586117	0	0
FAT4	79633	broad.mit.edu	37	4	126239462	126239462	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:126239462C>T	uc003ifj.3	+	1	1896	c.1896C>T	c.(1894-1896)TTC>TTT	p.F632F		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	632	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGAGGTCCTTCCGTCTGGATC	0.552													15	25					0	0	0.000308642	0	0
FAT4	79633	broad.mit.edu	37	4	126402778	126402778	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:126402778G>A	uc003ifj.3	+	15	12701	c.12701G>A	c.(12700-12702)CGA>CAA	p.R4234Q	FAT4_uc011cgp.1_Missense_Mutation_p.R2475Q|FAT4_uc003ifi.1_Missense_Mutation_p.R1712Q	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4234	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CAAAGCTTACGAGGTGCCATG	0.443													23	35					0	0	0.00278032	0	0
FAT4	79633	broad.mit.edu	37	4	126412574	126412574	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:126412574G>A	uc003ifj.3	+	17	14597	c.14597G>A	c.(14596-14598)AGA>AAA	p.R4866K	FAT4_uc011cgp.1_Missense_Mutation_p.R3107K|FAT4_uc003ifi.1_Missense_Mutation_p.R2343K	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4866	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TATACTTCCAGAATGCCCAAA	0.448													19	19					0	0	0.000958276	0	0
PHF17	79960	broad.mit.edu	37	4	129783278	129783278	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:129783278C>T	uc003igk.2	+	9	1681	c.1401C>T	c.(1399-1401)ATC>ATT	p.I467I	PHF17_uc003igj.2_Silent_p.I467I|PHF17_uc003igl.2_Silent_p.I455I|PHF17_uc011cgy.1_Silent_p.I467I|PHF17_uc003igm.2_Silent_p.I467I	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	467					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						AGCCCCTGATCACCCCAAAGA	0.532													29	33					0	0	0.00127121	0	0
CLGN	1047	broad.mit.edu	37	4	141315165	141315165	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:141315165G>A	uc011chi.1	-	12	1398	c.1180C>T	c.(1180-1182)CCA>TCA	p.P394S	CLGN_uc003iii.2_Missense_Mutation_p.P394S	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	394	Lumenal (Potential).|2-4.				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					AAATAATCTGGATTAGGAATT	0.328													13	21					0	0	0.00185496	0	0
ZNF330	27309	broad.mit.edu	37	4	142150761	142150761	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:142150761C>A	uc003iiq.3	+	6	548	c.328C>A	c.(328-330)CAT>AAT	p.H110N	ZNF330_uc011chl.1_Missense_Mutation_p.H50N	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	110						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					TTGGGTTTGCCATGGTAGGAA	0.463													52	57					9.72345e-25	3.34803e-24	0.000781405	1	0
LRBA	987	broad.mit.edu	37	4	151186938	151186938	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:151186938C>T	uc010ipj.2	-	58	9002	c.8528G>A	c.(8527-8529)GGA>GAA	p.G2843E	LRBA_uc010ipi.2_Missense_Mutation_p.G365E|LRBA_uc003ils.3_Missense_Mutation_p.G738E|LRBA_uc003ilt.3_Missense_Mutation_p.G1491E|LRBA_uc003ilu.3_Missense_Mutation_p.G2831E|LRBA_uc003ilr.3_Missense_Mutation_p.G263E	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	2843	WD 6.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CACAATGCTTCCTGAAGCCAT	0.463													29	7					0	0	0.00178596	0	0
SFRP2	6423	broad.mit.edu	37	4	154709599	154709599	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:154709599G>A	uc003inv.1	-	1	630	c.389C>T	c.(388-390)TCC>TTC	p.S130F		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	130	FZ.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				GCCGAAGGCGGACATGACCGG	0.652													26	9					0	0	0.000878237	0	0
TMEM144	55314	broad.mit.edu	37	4	159162695	159162695	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:159162695C>T	uc003ipx.2	+	11	1357	c.837C>T	c.(835-837)ACC>ACT	p.T279T	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	279	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		CTATAGCTACCTGCTGTTGGT	0.418													33	66					0	0	0.000953801	0	0
WDR17	116966	broad.mit.edu	37	4	177098301	177098301	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:177098301C>T	uc003iuj.2	+	29	3815	c.3659C>T	c.(3658-3660)ACC>ATC	p.T1220I	WDR17_uc003iuk.2_Missense_Mutation_p.T1196I|WDR17_uc003ium.3_Missense_Mutation_p.T1181I|WDR17_uc003iul.1_Intron|WDR17_uc003iun.2_Missense_Mutation_p.T431I	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	1220										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ACACAGTCCACCAACAGGTGA	0.373													10	4					0	0	0.00185496	0	0
ODZ3	55714	broad.mit.edu	37	4	183650332	183650332	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:183650332G>A	uc003ivd.1	+	13	2620	c.2583G>A	c.(2581-2583)AAG>AAA	p.K861K	ODZ3_uc003ive.1_Silent_p.K267K	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	861	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CTTTCAATAAGAGGTTAATGC	0.378													18	3					0	0	0.00074312	0	0
KLKB1	3818	broad.mit.edu	37	4	187172454	187172455	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:187172454_187172455CC>TT	uc003iyy.2	+	8	911_912	c.840_841CC>TT	c.(838-843)AGCCTT>AGTTTT	p.L281F	KLKB1_uc011clc.1_Missense_Mutation_p.L79F|KLKB1_uc011cld.1_Missense_Mutation_p.L243F	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	281	Apple 3.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		CTGGATATAGCCTTTTAACCTG	0.297													35	15					0	0	6.4e-05	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455191	187455191	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr4:187455191C>T	uc003izd.1	-	2	723	c.705G>A	c.(703-705)AGG>AGA	p.R235R		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	235	Cytoplasmic (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TGACAAAATTCCTGAAGTCCT	0.502													29	14					0	0	0.00178596	0	0
AHRR	57491	broad.mit.edu	37	5	434374	434374	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:434374A>T	uc003jav.2	+	12	1629	c.1585A>T	c.(1585-1587)ATG>TTG	p.M529L	AHRR_uc003jaw.2_Missense_Mutation_p.M507L|AHRR_uc010isy.2_Missense_Mutation_p.M357L|AHRR_uc010isz.2_Missense_Mutation_p.M507L|AHRR_uc003jax.2_Missense_Mutation_p.M270L|AHRR_uc003jay.2_Missense_Mutation_p.M367L|AHRR_uc003jaz.2_Missense_Mutation_p.M128L	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GGGCTATCCCATGGAGGACAT	0.617													25	18					0	0	0.000586117	0	0
SLC6A18	348932	broad.mit.edu	37	5	1243685	1243685	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:1243685G>A	uc003jby.1	+	9	1270	c.1147G>A	c.(1147-1149)GGC>AGC	p.G383S		NM_182632	NP_872438	Q96N87	S6A18_HUMAN	solute carrier family 6, member 18	383	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(1)	1	all_cancers(3;2.99e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.76e-10)		Epithelial(17;0.000356)|all cancers(22;0.00124)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CTCGGGCCCGGGCCTGGCCTT	0.642													44	84					0	0	0.000781405	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5190095	5190095	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:5190095G>A	uc003jdl.2	+	7	1197	c.1059G>A	c.(1057-1059)GTG>GTA	p.V353V	ADAMTS16_uc003jdk.1_Silent_p.V353V|ADAMTS16_uc003jdj.1_Silent_p.V353V	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	353	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CAGGACTGGTGATAAGTCACC	0.473													45	60					0	0	0.000781405	0	0
PAPD7	11044	broad.mit.edu	37	5	6753029	6753029	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:6753029T>C	uc003jdx.1	+	12	1442	c.1313T>C	c.(1312-1314)GTT>GCT	p.V438A	PAPD7_uc011cmn.1_Missense_Mutation_p.V429A|PAPD7_uc010itl.1_Missense_Mutation_p.V258A	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	438					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						GTTGCTCCTGTTCCTTGCAGA	0.547													67	10					0	0	0.000781405	0	0
DNAH5	1767	broad.mit.edu	37	5	13700980	13700980	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:13700980C>T	uc003jfd.2	-	78	13534	c.13492G>A	c.(13492-13494)GAA>AAA	p.E4498K	DNAH5_uc003jfc.2_Missense_Mutation_p.E666K	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4498					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGAGTTATTTCCTATTCAGGG	0.453									Kartagener_syndrome				71	10					0	0	0.000781405	0	0
DNAH5	1767	broad.mit.edu	37	5	13781030	13781030	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:13781030G>A	uc003jfd.2	-	53	8901	c.8859C>T	c.(8857-8859)CTC>CTT	p.L2953L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2953	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCCCGACCAGGAGGGCATTTC	0.458									Kartagener_syndrome				22	5					0	0	0.000720815	0	0
DNAH5	1767	broad.mit.edu	37	5	13931332	13931332	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:13931332C>T	uc003jfd.2	-	2	121	c.79G>A	c.(79-81)GAA>AAA	p.E27K	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	27	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGCTTGGCTTCCTTCTCTCCC	0.393									Kartagener_syndrome				72	7					0	0	0.000781405	0	0
CDH18	1016	broad.mit.edu	37	5	19571815	19571815	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:19571815C>T	uc003jgc.2	-	7	1503	c.1126G>A	c.(1126-1128)GAT>AAT	p.D376N	CDH18_uc003jgd.2_Missense_Mutation_p.D376N|CDH18_uc011cnm.1_Missense_Mutation_p.D376N	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	376	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCATCTACATCCCCAACAATG	0.418													33	0					0	0	0.00058488	0	0
PRDM9	56979	broad.mit.edu	37	5	23526472	23526472	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:23526472C>T	uc003jgo.2	+	11	1457	c.1275C>T	c.(1273-1275)CTC>CTT	p.L425L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	425					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GAAAACTCCTCCAACCAGAGA	0.463										HNSCC(3;0.000094)			77	7					0	0	0.000781405	0	0
RNASEN	29102	broad.mit.edu	37	5	31422952	31422952	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:31422952C>A	uc003jhg.2	-	28	3720	c.3361G>T	c.(3361-3363)GTT>TTT	p.V1121F	RNASEN_uc003jhh.2_Missense_Mutation_p.V1084F|RNASEN_uc003jhi.2_Missense_Mutation_p.V1084F	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	1121	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|RNase III 2.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						AGAAGTCGAACATGAGTAAAA	0.388													26	2					9.04412e-07	3.07736e-06	0.000720815	1	0
PDZD2	23037	broad.mit.edu	37	5	31799773	31799773	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:31799773G>A	uc003jhl.2	+	2	806	c.418G>A	c.(418-420)GAT>AAT	p.D140N	PDZD2_uc003jhm.2_Missense_Mutation_p.D140N	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	140	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CCGACTGCGGGATGAGATCCT	0.597													44	68					0	0	0.000781405	0	0
PDZD2	23037	broad.mit.edu	37	5	32074472	32074472	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:32074472T>C	uc003jhl.2	+	18	3648	c.3260T>C	c.(3259-3261)TTG>TCG	p.L1087S	PDZD2_uc003jhm.2_Missense_Mutation_p.L1087S|PDZD2_uc011cnx.1_Missense_Mutation_p.L913S	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1087					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GCACCCAAATTGGAATACACA	0.587													62	86					0	0	0.000781405	0	0
MTMR12	54545	broad.mit.edu	37	5	32242174	32242174	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:32242174A>G	uc003jhq.2	-	12	1330	c.1160T>C	c.(1159-1161)GTT>GCT	p.V387A	MTMR12_uc010iuk.2_Missense_Mutation_p.V387A|MTMR12_uc010iul.2_Missense_Mutation_p.V387A	NM_001040446	NP_001035536	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	387	Myotubularin phosphatase.					cytoplasm	phosphatase activity			ovary(1)	1						TAAAAGAAGAACATTCATGTT	0.328													19	39					0	0	0.00229938	0	0
RXFP3	51289	broad.mit.edu	37	5	33938078	33938078	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:33938078G>A	uc003jic.1	+	1	1590	c.1233G>A	c.(1231-1233)TCG>TCA	p.S411S		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	411	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						CGTCTCCTTCGATCACCAGCA	0.567													25	27					0	0	0.00106085	0	0
C5orf42	65250	broad.mit.edu	37	5	37183667	37183667	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:37183667C>T	uc011cpa.1	-	26	4847	c.4616G>A	c.(4615-4617)GGT>GAT	p.G1539D	C5orf42_uc011coy.1_Missense_Mutation_p.G40D|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.G614D|C5orf42_uc011cpb.1_Missense_Mutation_p.G420D	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1539										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TTCCCAAACACCTATTACAGG	0.323													29	4					0	0	0.00106085	0	0
OSMR	9180	broad.mit.edu	37	5	38919081	38919081	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:38919081C>T	uc003jln.1	+	11	1869	c.1502C>T	c.(1501-1503)TCC>TTC	p.S501F	OSMR_uc011cpj.1_5'UTR	NM_003999	NP_003990	Q99650	OSMR_HUMAN	oncostatin M receptor precursor	501	Fibronectin type-III 2.|Extracellular (Potential).				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_lung(31;0.000365)					GACAGGTGTTCCTACCAAATC	0.438													33	6					0	0	0.00111076	0	0
DAB2	1601	broad.mit.edu	37	5	39376177	39376178	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:39376177_39376178GG>AA	uc003jlx.2	-	13	2699_2700	c.2168_2169CC>TT	c.(2167-2169)TCC>TTT	p.S723F	DAB2_uc003jlw.2_Missense_Mutation_p.S702F	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	723	Required for interaction with MYO6 (By similarity).				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			TAACTGGCAGGGAAACTTGTCT	0.436													28	3					0	0	6.4e-05	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41057398	41057398	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:41057398C>T	uc003jmj.3	-	8	1311	c.821G>A	c.(820-822)AGA>AAA	p.R274K	HEATR7B2_uc003jmi.3_Intron	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	274	HEAT 3.						binding			ovary(6)|central_nervous_system(2)	8						AAAGATGGATCTTCTCAAGCT	0.413													6	2					0	0	0.00198382	0	0
NNT	23530	broad.mit.edu	37	5	43659398	43659398	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:43659398C>T	uc003joe.2	+	17	2835	c.2580C>T	c.(2578-2580)ATC>ATT	p.I860I	NNT_uc003jof.2_Silent_p.I860I	NM_012343	NP_036475	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	860	Helical; (Potential).				tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(6;2.58e-06)				NADH(DB00157)	TGCTGACCATCGTGGGTGCAC	0.507													54	9					0	0	0.000781405	0	0
IL31RA	133396	broad.mit.edu	37	5	55212752	55212752	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:55212752C>T	uc003jql.2	+	15	2164	c.2099C>T	c.(2098-2100)TCC>TTC	p.S700F	IL31RA_uc003jqm.2_Intron|IL31RA_uc003jqn.2_Intron|IL31RA_uc003jqo.2_Missense_Mutation_p.S558F	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	668	Cytoplasmic (Potential).				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CCCAGAAAATCCCAATACCTA	0.512													41	60					0	0	0.00148497	0	0
IL6ST	3572	broad.mit.edu	37	5	55237154	55237154	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:55237154G>A	uc003jqq.2	-	17	2768	c.2513C>T	c.(2512-2514)TCA>TTA	p.S838L	uc003jqp.2_5'Flank|IL6ST_uc010iwb.2_Missense_Mutation_p.S777L|IL6ST_uc010iwc.2_3'UTR|IL6ST_uc010iwd.2_Missense_Mutation_p.S157L|IL6ST_uc011cqk.1_Missense_Mutation_p.S549L|IL6ST_uc003jqr.2_3'UTR	NM_002184	NP_002175	P40189	IL6RB_HUMAN	interleukin 6 signal transducer isoform 1	838	Cytoplasmic (Potential).				interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			large_intestine(1)|ovary(1)	2		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				ATTGACTGATGAAACTTGCTT	0.383			O		hepatocellular ca								67	90					0	0	0.000781405	0	0
ELOVL7	79993	broad.mit.edu	37	5	60053414	60053414	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:60053414G>A	uc003jsi.3	-	8	758	c.558C>T	c.(556-558)TCC>TCT	p.S186S	ELOVL7_uc011cqo.1_Silent_p.S99S|ELOVL7_uc010iwk.2_Silent_p.S186S|ELOVL7_uc003jsj.3_Silent_p.S173S	NM_024930	NP_079206	A1L3X0	ELOV7_HUMAN	elongation of very long chain fatty acids-like	186	Helical; (Potential).				fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0		Lung NSC(810;2.56e-06)|Prostate(74;0.0115)|Breast(144;0.0244)|Ovarian(174;0.0481)				GTCCATAGTAGGAATACATGA	0.373													24	31					0	0	0.00047179	0	0
KIF2A	3796	broad.mit.edu	37	5	61648535	61648535	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:61648535C>T	uc003jsy.3	+	5	766	c.455C>T	c.(454-456)CCT>CTT	p.P152L	KIF2A_uc003jsz.3_Missense_Mutation_p.P152L|KIF2A_uc010iwp.2_Intron|KIF2A_uc003jsx.3_Missense_Mutation_p.P132L|KIF2A_uc010iwq.2_5'UTR	NM_004520	NP_004511	O00139	KIF2A_HUMAN	kinesin heavy chain member 2 isoform 1	152	Globular (Potential).				blood coagulation|cell differentiation|cell division|microtubule-based movement|mitotic prometaphase|mitotic spindle organization|nervous system development	centrosome|cytosol|microtubule|spindle pole	ATP binding|microtubule motor activity|protein binding				0		Lung NSC(810;8.94e-06)|Prostate(74;0.0132)|Ovarian(174;0.051)|Breast(144;0.077)		Lung(70;0.14)		TTTGGACCCCCTTGTATGTAA	0.378													13	23					0	0	0.00185496	0	0
BDP1	55814	broad.mit.edu	37	5	70837355	70837355	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:70837355C>T	uc003kbp.1	+	29	6360	c.6097C>T	c.(6097-6099)CAC>TAC	p.H2033Y	BDP1_uc003kbo.2_Missense_Mutation_p.H2033Y|BDP1_uc003kbq.1_RNA|BDP1_uc003kbr.1_RNA	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	2033					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TAATGTAAATCACAAAATTGT	0.313													74	126					0	0	0.000781405	0	0
TMEM174	134288	broad.mit.edu	37	5	72469311	72469311	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:72469311G>A	uc010izc.2	+	1	289	c.241G>A	c.(241-243)GTT>ATT	p.V81I		NM_153217	NP_694949	Q8WUU8	TM174_HUMAN	transmembrane protein 174	81	Helical; (Potential).					integral to membrane				ovary(1)	1		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		CCTGCTGTCAGTTGGGGTGAC	0.532													52	64					0	0	0.000781405	0	0
RGNEF	64283	broad.mit.edu	37	5	72980679	72980679	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:72980679G>A	uc011csq.1	+	1	14	c.3G>A	c.(1-3)ATG>ATA	p.M1I	RGNEF_uc003kcx.2_Missense_Mutation_p.M1I|RGNEF_uc003kcy.1_Missense_Mutation_p.M1I|RGNEF_uc010izf.2_Missense_Mutation_p.M1I	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	1					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		CGAAAGCCATGGAGTTGAGCT	0.483													23	42					0	0	0.00278032	0	0
FAM169A	26049	broad.mit.edu	37	5	74130379	74130379	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:74130379C>T	uc003kdm.2	-	5	405	c.362G>A	c.(361-363)CGA>CAA	p.R121Q	FAM169A_uc010izm.2_Missense_Mutation_p.R121Q|FAM169A_uc003kdl.2_Intron	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	121											0						ATAAATAATTCGATTCAGAAC	0.408													18	22					0	0	0.00121646	0	0
HMGCR	3156	broad.mit.edu	37	5	74645867	74645868	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:74645867_74645868GG>TT	uc003kdp.2	+	7	713_714	c.557_558GG>TT	c.(556-558)GGG>GTT	p.G186V	HMGCR_uc011cst.1_Missense_Mutation_p.G206V|HMGCR_uc003kdq.2_Missense_Mutation_p.G186V|HMGCR_uc010izn.1_Missense_Mutation_p.G26V	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	186	Helical; (Potential).				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CTCTAACCAGGGGTACGTCAGC	0.391													14	513					0	0	6.4e-05	0	0
SV2C	22987	broad.mit.edu	37	5	75427893	75427893	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:75427893C>T	uc003kei.1	+	2	452	c.318C>T	c.(316-318)ATC>ATT	p.I106I		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	106	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		AGGACAGCATCGTGTCAGTGG	0.552													22	21					0	0	0.00152264	0	0
F2RL1	2150	broad.mit.edu	37	5	76128963	76128963	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:76128963C>T	uc003keo.2	+	2	706	c.531C>T	c.(529-531)ATC>ATT	p.I177I		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	177	Cytoplasmic (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		ATTGGGTCATCGTGAACCCCA	0.483													255	352					0	0	0.000781405	0	0
BHMT2	23743	broad.mit.edu	37	5	78379595	78379596	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:78379595_78379596GG>AA	uc003kft.2	+	7	949_950	c.926_927GG>AA	c.(925-927)AGG>AAA	p.R309K	BHMT2_uc011cth.1_Missense_Mutation_p.R245K	NM_017614	NP_060084	Q9H2M3	BHMT2_HUMAN	betaine-homocysteine methyltransferase 2	309					methionine biosynthetic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00063)|Lung NSC(167;0.00171)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;2.09e-45)|Epithelial(54;9.3e-41)|all cancers(79;4.09e-36)	L-Methionine(DB00134)	GCCCCAGAAAGGGGCTTTTTGC	0.53													20	24					0	0	6.4e-05	0	0
CMYA5	202333	broad.mit.edu	37	5	79027814	79027814	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:79027814G>A	uc003kgc.2	+	2	3298	c.3226G>A	c.(3226-3228)GAA>AAA	p.E1076K		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1076						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GTCTCCGCTTGAAGACTTAAG	0.413													32	36					0	0	0.00209593	0	0
SPATA9	83890	broad.mit.edu	37	5	95011280	95011280	+	Nonsense_Mutation	SNP	G	A	A	rs114848300	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:95011280G>A	uc003klj.1	-	3	370	c.214C>T	c.(214-216)CGA>TGA	p.R72*	SPATA9_uc010jbh.1_RNA|SPATA9_uc003klh.1_RNA|SPATA9_uc003kli.1_Intron	NM_031952	NP_114158	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	72					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane					0		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		AATGTTGCTCGATTAATCTTA	0.393													42	30					0	0	0.000680045	0	0
RHOBTB3	22836	broad.mit.edu	37	5	95116051	95116051	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:95116051C>T	uc003klm.2	+	9	1915	c.1378C>T	c.(1378-1380)CTG>TTG	p.L460L		NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	460	BTB 2.|Interaction with Rab9.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		AAAGAGTGTCCTGATTCCCGT	0.458													27	19					0	0	0.000878237	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101735366	101735366	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:101735366C>T	uc003knn.2	-	10	1879	c.1707G>A	c.(1705-1707)GGG>GGA	p.G569G	SLCO6A1_uc003kno.2_Silent_p.G316G|SLCO6A1_uc003knp.2_Silent_p.G569G|SLCO6A1_uc003knq.2_Silent_p.G507G	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	569	Extracellular (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CATCACATTTCCCGGGTCTGG	0.368													40	32					0	0	0.0025221	0	0
MAN2A1	4124	broad.mit.edu	37	5	109183456	109183456	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:109183456C>T	uc003kou.1	+	19	3904	c.2941C>T	c.(2941-2943)CGA>TGA	p.R981*		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	981	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TAATCTATTTCGAATACTACT	0.343													21	10					0	0	0.000878237	0	0
STARD4	134429	broad.mit.edu	37	5	110835631	110835631	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:110835631C>T	uc003kph.1	-	6	655	c.571G>A	c.(571-573)GCA>ACA	p.A191T	STARD4_uc010jbw.1_Missense_Mutation_p.A93T|STARD4_uc010jbx.1_Missense_Mutation_p.A93T|STARD4_uc003kpi.1_RNA	NM_139164	NP_631903	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain	191	START.				lipid transport		lipid binding			ovary(1)	1		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		AAAGTGCTTGCCATGGCTGTA	0.408													20	53					0	0	0.00278032	0	0
SRP19	6728	broad.mit.edu	37	5	112198222	112198222	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:112198222C>A	uc003kqc.2	+	2	140	c.59C>A	c.(58-60)CCT>CAT	p.P20H	SRP19_uc003kqb.1_Missense_Mutation_p.P20H|SRP19_uc011cvu.1_Translation_Start_Site|SRP19_uc011cvv.1_Translation_Start_Site	NM_003135	NP_003126	P09132	SRP19_HUMAN	signal recognition particle 19kDa	20					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|mitochondrion|nucleolus|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding				0		all_cancers(142;0.00328)|all_epithelial(76;6.39e-05)|Prostate(80;0.00174)|Colorectal(10;0.00372)|Ovarian(225;0.156)		Epithelial(69;1.7e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.17e-08)|all cancers(49;3.96e-07)|Colorectal(14;0.0056)|COAD - Colon adenocarcinoma(37;0.0104)		TGTATCTATCCTGCTTATTTA	0.343													13	13					4.3838e-07	1.49227e-06	0.00185496	1	0
DCP2	167227	broad.mit.edu	37	5	112339742	112339742	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:112339742C>T	uc003kqh.2	+	8	1108	c.910C>T	c.(910-912)CAT>TAT	p.H304Y	DCP2_uc011cwa.1_Missense_Mutation_p.H93Y|DCP2_uc010jcc.2_Missense_Mutation_p.H210Y	NM_152624	NP_689837	Q8IU60	DCP2_HUMAN	DCP2 decapping enzyme	304					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|protein binding|RNA binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		ATATAATAATCATTCTGAAAT	0.388													12	27					0	0	0.00185496	0	0
TSSK1B	83942	broad.mit.edu	37	5	112769639	112769639	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:112769639G>A	uc003kqm.2	-	1	1090	c.898C>T	c.(898-900)CCC>TCC	p.P300S	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	300					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		CCAGGTTCGGGGGTCCACAAG	0.622													11	23					0	0	0.000673444	0	0
CDO1	1036	broad.mit.edu	37	5	115146962	115146962	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:115146962C>T	uc003krg.2	-	3	610	c.299G>A	c.(298-300)GGA>GAA	p.G100E		NM_001801	NP_001792	Q16878	CDO1_HUMAN	cysteine dioxygenase	100					inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			large_intestine(1)|skin(1)	2		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)	CTTTAGATTTCCCTGTAGCAT	0.408													82	62					0	0	0.000781405	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759307	121759307	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:121759307C>T	uc003ksw.1	+	4	1081	c.875C>T	c.(874-876)TCC>TTC	p.S292F	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.S292F|SNCAIP_uc003ksx.1_Missense_Mutation_p.S339F|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.S292F	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	292					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GCAGCAGAATCCAAACCAGAA	0.473													10	32					0	0	0.000442599	0	0
SNCAIP	9627	broad.mit.edu	37	5	121786742	121786742	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:121786742C>T	uc003ksw.1	+	10	2406	c.2200C>T	c.(2200-2202)CCT>TCT	p.P734S	SNCAIP_uc011cwl.1_Missense_Mutation_p.P292S|SNCAIP_uc003ksx.1_Missense_Mutation_p.P781S|SNCAIP_uc003ksy.1_Missense_Mutation_p.P368S|SNCAIP_uc003ksz.1_Missense_Mutation_p.P368S|SNCAIP_uc010jcu.2_Missense_Mutation_p.P330S|SNCAIP_uc011cwm.1_Missense_Mutation_p.P368S|SNCAIP_uc003kta.1_Missense_Mutation_p.P366S|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.P428S|SNCAIP_uc010jcx.1_Missense_Mutation_p.P674S|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Missense_Mutation_p.P250S	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	734					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACGCAGGTTTCCTTTCAGCAT	0.547													34	14					0	0	0.00283554	0	0
SNCAIP	9627	broad.mit.edu	37	5	121787254	121787254	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:121787254G>A	uc003ksw.1	+	10	2918	c.2712G>A	c.(2710-2712)AAG>AAA	p.K904K	SNCAIP_uc011cwl.1_Silent_p.K462K|SNCAIP_uc003ksx.1_Silent_p.K951K|SNCAIP_uc003ksy.1_Silent_p.K538K|SNCAIP_uc003ksz.1_Silent_p.K538K|SNCAIP_uc010jcu.2_Silent_p.K500K|SNCAIP_uc011cwm.1_Silent_p.K538K|SNCAIP_uc003kta.1_Silent_p.K536K|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Silent_p.K598K|SNCAIP_uc010jcx.1_Silent_p.K844K|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Silent_p.K420K	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	904					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CAGATGCCAAGGGAAACCCTG	0.423													44	45					0	0	0.000781405	0	0
SNX24	28966	broad.mit.edu	37	5	122281819	122281819	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:122281819G>A	uc011cwo.1	+	3	383	c.214G>A	c.(214-216)GAA>AAA	p.E72K	SNX24_uc003ktf.2_Missense_Mutation_p.E72K|SNX24_uc010jcy.2_Missense_Mutation_p.E72K	NM_014035	NP_054754	Q9Y343	SNX24_HUMAN	SBBI31 protein	72	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding				0		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		CAAAGTCTTGGAACAGCGACG	0.333													15	23					0	0	0.000958276	0	0
CEP120	153241	broad.mit.edu	37	5	122722351	122722351	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:122722351G>A	uc003ktk.2	-	11	1523	c.1441C>T	c.(1441-1443)CCA>TCA	p.P481S	CEP120_uc011cwq.1_Missense_Mutation_p.P290S|CEP120_uc010jcz.1_Missense_Mutation_p.P455S	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	481						centrosome				ovary(1)	1						CCAAAGAATGGATATGAGTAC	0.303													14	25					0	0	0.00185496	0	0
CEP120	153241	broad.mit.edu	37	5	122758678	122758678	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:122758678G>A	uc003ktk.2	-	2	97	c.15C>T	c.(13-15)TCC>TCT	p.S5S	CEP120_uc011cwq.1_5'UTR|CEP120_uc010jcz.1_Intron	NM_153223	NP_694955	Q8N960	CE120_HUMAN	coiled-coil domain containing 100	5						centrosome				ovary(1)	1						GCAATTGGTCGGATTTGGAGA	0.607													64	45					0	0	0.000781405	0	0
ZNF608	57507	broad.mit.edu	37	5	123977036	123977036	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:123977036G>A	uc003ktq.1	-	7	4482	c.4359C>T	c.(4357-4359)TCC>TCT	p.S1453S	ZNF608_uc003ktr.1_Intron|ZNF608_uc003ktp.1_Silent_p.S148S	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1453						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GGCCGAAGGGGGAGTGGCGAT	0.572													13	42					0	0	0.00244969	0	0
FBN2	2201	broad.mit.edu	37	5	127616001	127616001	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:127616001C>T	uc003kuu.2	-	56	7460	c.7021G>A	c.(7021-7023)GAA>AAA	p.E2341K		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2341	EGF-like 40; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GTCCTGCATTCATTTTCATCT	0.318													14	41					0	0	0.000308642	0	0
ANKRD43	134548	broad.mit.edu	37	5	132150734	132150734	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:132150734C>T	uc003kxw.2	+	1	1702	c.1421C>T	c.(1420-1422)TCC>TTC	p.S474F		NM_175873	NP_787069	Q2M3V2	ANR43_HUMAN	ankyrin repeat domain 43 precursor	474											0		all_cancers(142;0.086)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ATCCTCAGTTCCACCACCAGT	0.637													10	10					0	0	0.000442599	0	0
SHROOM1	134549	broad.mit.edu	37	5	132161667	132161667	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:132161667G>A	uc003kxx.2	-	4	971	c.166C>T	c.(166-168)CCT>TCT	p.P56S	SHROOM1_uc003kxy.1_Missense_Mutation_p.P56S	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	56					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCTAGGTAAGGAAGGAGGTCT	0.493													4	5					0	0	0.00024832	0	0
SHROOM1	134549	broad.mit.edu	37	5	132161783	132161783	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:132161783G>A	uc003kxx.2	-	4	855	c.50C>T	c.(49-51)ACT>ATT	p.T17I	SHROOM1_uc003kxy.1_Missense_Mutation_p.T17I	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	17					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAGGCTGCTAGTGGACGAGGC	0.711													16	6					0	0	0.00121646	0	0
FSTL4	23105	broad.mit.edu	37	5	132585175	132585176	+	Missense_Mutation	DNP	CC	TT	TT	rs151107205		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:132585175_132585176CC>TT	uc003kyn.1	-	7	1038_1039	c.820_821GG>AA	c.(820-822)GGA>AAA	p.G274K		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	274	Ig-like 1.					extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTCAGGTCTCCATGGACGGCG	0.584													17	22					0	0	6.4e-05	0	0
FSTL4	23105	broad.mit.edu	37	5	132939621	132939621	+	Silent	SNP	C	T	T	rs148304695		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:132939621C>T	uc003kyn.1	-	2	272	c.54G>A	c.(52-54)CCG>CCA	p.P18P		NM_015082	NP_055897	Q6MZW2	FSTL4_HUMAN	follistatin-like 4 precursor	18						extracellular region	calcium ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCAGCGCAGCCGGCAGGGAGG	0.527													37	38					0	0	0.00128727	0	0
IL9	3578	broad.mit.edu	37	5	135228119	135228119	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:135228119G>A	uc003lbb.1	-	5	407	c.396C>T	c.(394-396)TTC>TTT	p.F132F		NM_000590	NP_000581	P15248	IL9_HUMAN	interleukin 9 precursor	132					immune response|inflammatory response|positive regulation of cell proliferation|positive regulation of interleukin-5 biosynthetic process	extracellular space	cytokine activity|cytokine receptor binding|growth factor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTTCTTTCTGGAAAATTTCCA	0.368													31	60					0	0	0.0024448	0	0
TRPC7	57113	broad.mit.edu	37	5	135583275	135583275	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:135583275C>T	uc003lbn.1	-	6	1728	c.1725G>A	c.(1723-1725)GTG>GTA	p.V575V	TRPC7_uc010jef.1_Silent_p.V512V|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.V506V|TRPC7_uc010jei.1_Silent_p.V451V|TRPC7_uc010jej.1_Silent_p.V127V	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	576	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGATATCTTTCACAGTTCTCC	0.473													33	75					0	0	0.00170553	0	0
BRD8	10902	broad.mit.edu	37	5	137481567	137481567	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:137481567C>T	uc003lcf.1	-	24	3334	c.3279G>A	c.(3277-3279)CTG>CTA	p.L1093L	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	1093					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTAGATCAGTCCTATGAGGAT	0.418													41	33					0	0	0.00195071	0	0
KDM3B	51780	broad.mit.edu	37	5	137727415	137727415	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:137727415C>T	uc003lcy.1	+	8	2294	c.2094C>T	c.(2092-2094)TCC>TCT	p.S698S	KDM3B_uc010jew.1_Silent_p.S354S|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	698	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						CAACTGACTCCTCCAAGCTAG	0.582													32	22					0	0	0.00178596	0	0
KDM3B	51780	broad.mit.edu	37	5	137756620	137756620	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:137756620C>T	uc003lcy.1	+	15	4141	c.3941C>T	c.(3940-3942)CCC>CTC	p.P1314L	KDM3B_uc010jew.1_Missense_Mutation_p.P970L|KDM3B_uc011cys.1_Missense_Mutation_p.P346L	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	jumonji domain containing 1B	1314					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(3)|upper_aerodigestive_tract(2)|lung(2)|kidney(2)|central_nervous_system(1)|skin(1)	11						ACAGGCATACCCTTTCCCCCG	0.512													40	20					0	0	0.000781405	0	0
HSPA9	3313	broad.mit.edu	37	5	137893590	137893590	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:137893590G>C	uc003ldf.2	-	13	1709	c.1601C>G	c.(1600-1602)GCT>GGT	p.A534G	HSPA9_uc003lde.2_5'Flank|HSPA9_uc011cyw.1_Intron	NM_004134	NP_004125	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 precursor	534					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TTTATCTTTAGCAGAAACATG	0.428													20	74					0	0	0.00121646	0	0
PSD2	84249	broad.mit.edu	37	5	139189215	139189215	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:139189215C>T	uc003leu.1	+	2	395	c.190C>T	c.(190-192)CCA>TCA	p.P64S		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	64					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACGAAGGACCCAGATGTGGC	0.627													21	48					0	0	0.00047179	0	0
SLC4A9	83697	broad.mit.edu	37	5	139748220	139748220	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:139748220C>T	uc003lfm.2	+	17	2510	c.2475C>T	c.(2473-2475)TCC>TCT	p.S825S	SLC4A9_uc003lfj.2_Silent_p.S801S|SLC4A9_uc011czg.1_Silent_p.S738S|SLC4A9_uc003lfl.2_Silent_p.S801S|SLC4A9_uc003lfk.2_Silent_p.S787S	NM_031467	NP_113655	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate	825	Membrane (anion exchange).|Helical; (Potential).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			large_intestine(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGAGCCTCCATCTTCCTGG	0.493													12	39					0	0	0.00244969	0	0
IK	3550	broad.mit.edu	37	5	140035472	140035472	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140035472C>T	uc003lgq.2	+	9	806	c.696C>T	c.(694-696)TTC>TTT	p.F232F	IK_uc011czk.1_Silent_p.F232F	NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	232					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGAGTTGTTCCTGCCGGGCC	0.502													9	10					0	0	0.000673444	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202001	140202001	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140202001C>T	uc003lhl.2	+	1	641	c.641C>T	c.(640-642)ACT>ATT	p.T214I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.T214I|PCDHA5_uc003lhj.1_Missense_Mutation_p.T214I	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	214	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGATTGCAACTGATGGAGGA	0.348													57	35					0	0	0.000781405	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229475	140229475	+	Silent	SNP	G	A	A	rs17844330		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140229475G>A	uc003lhu.2	+	1	2119	c.1395G>A	c.(1393-1395)AAG>AAA	p.K465K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.K465K	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	465	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTCGTGAAGGAGAACAACC	0.662													43	2					0	0	0.00195071	0	0
PCDHA12	56137	broad.mit.edu	37	5	140257385	140257385	+	Silent	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140257385T>A	uc003lic.2	+	1	2455	c.2328T>A	c.(2326-2328)CTT>CTA	p.L776L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.L776L	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	776	5 X 4 AA repeats of P-X-X-P.|Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCAAGCCTTCAGCTGTCTC	0.478													8	15					0	0	0.000442599	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263148	140263148	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140263148C>T	uc003lif.2	+	1	1295	c.1295C>T	c.(1294-1296)TCG>TTG	p.S432L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.S432L|PCDHA13_uc003lid.2_Missense_Mutation_p.S432L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	432	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGGGGGCTCGCCTTCGCTG	0.652													57	65					0	0	0.000781405	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263830	140263830	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140263830G>A	uc003lif.2	+	1	1977	c.1977G>A	c.(1975-1977)CTG>CTA	p.L659L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.L659L|PCDHA13_uc003lid.2_Silent_p.L659L	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	659	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCCGCGCTGACGGCCACGG	0.697													22	64					0	0	0.00188189	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307836	140307836	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140307836C>T	uc003lih.2	+	1	1535	c.1359C>T	c.(1357-1359)TTC>TTT	p.F453F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Silent_p.F453F	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	453	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAACTTTTCGTTGCTGAAA	0.532													47	40					0	0	0.000781405	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308012	140308012	+	Missense_Mutation	SNP	C	T	T	rs137957181		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140308012C>T	uc003lih.2	+	1	1711	c.1535C>T	c.(1534-1536)TCC>TTC	p.S512F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.S512F	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	512	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAAAACTTCCTTTGACTTT	0.493													25	69					0	0	0.00047179	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482426	140482426	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140482426C>T	uc003lio.2	+	1	2193	c.2193C>T	c.(2191-2193)CCC>CCT	p.P731P	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	731	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGAGGGCCCCTTTCCAGGGC	0.652													53	32					0	0	0.000781405	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502793	140502793	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140502793G>A	uc003lip.1	+	1	1213	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	405	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTGGTAACAGAGAGACCACT	0.453													7	33					0	0	0.00198382	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554346	140554346	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140554346G>A	uc003lit.2	+	1	2104	c.1930G>A	c.(1930-1932)GTC>ATC	p.V644I		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	644	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGTGCTGGTCAAGGACAA	0.711													22	20					0	0	0.00178596	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558523	140558523	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140558523G>A	uc011dai.1	+	1	1094	c.908G>A	c.(907-909)CGA>CAA	p.R303Q	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	303	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGAAATTCGACTAAAGAAA	0.393													37	57					0	0	0.000953801	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559618	140559618	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140559618C>T	uc011dai.1	+	1	2189	c.2003C>T	c.(2002-2004)TCC>TTC	p.S668F	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	668	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACGGCTTCTCCCAGCCCTAC	0.687													29	25					0	0	0.00209593	0	0
PCDHB12	56124	broad.mit.edu	37	5	140588986	140588986	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140588986C>T	uc003liz.2	+	1	696	c.507C>T	c.(505-507)AGC>AGT	p.S169S	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	169	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGTAAAAAGCTACACAATAA	0.393													15	41					0	0	0.000308642	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590624	140590624	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140590624G>A	uc003liz.2	+	1	2334	c.2145G>A	c.(2143-2145)AGG>AGA	p.R715R	PCDHB12_uc011dak.1_Silent_p.R378R|PCDHB13_uc003lja.1_5'Flank	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	715	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCTGTGCAGGAGGAGCAGGG	0.672													36	106					0	0	0.00195071	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710337	140710337	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140710337G>A	uc003lji.1	+	1	86	c.86G>A	c.(85-87)GGG>GAG	p.G29E	PCDHGA1_uc011dan.1_Missense_Mutation_p.G29E	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	29	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGGGCTGGGAATATTCAC	0.542													31	65					0	0	0.001512	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140746171	140746171	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140746171C>T	uc003lju.1	+	1	2274	c.2274C>T	c.(2272-2274)TCC>TCT	p.S758S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.S758S	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	758	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGAGGTCTCCCTCACCGCGG	0.597													65	46					0	0	0.000781405	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754309	140754309	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140754309C>T	uc003ljy.1	+	1	659	c.659C>T	c.(658-660)CCT>CTT	p.P220L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.P220L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	220	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGCGACCCTGTCCGCTCA	0.557													6	12					0	0	0.00116845	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140754840	140754840	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140754840C>T	uc003ljy.1	+	1	1190	c.1190C>T	c.(1189-1191)TCA>TTA	p.S397L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Missense_Mutation_p.S397L	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	397	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGAAAAATCAGTTGGCAAT	0.453													34	56					0	0	0.00058488	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140763703	140763703	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140763703G>A	uc003lka.1	+	1	1237	c.1237G>A	c.(1237-1239)GAA>AAA	p.E413K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.E413K	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	413	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTGGACCGGGAAACACTCTC	0.413													5	13					0	0	0.00116845	0	0
PCDHGB5	56101	broad.mit.edu	37	5	140780033	140780033	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140780033C>T	uc003lkf.1	+	1	2339	c.2339C>T	c.(2338-2340)TCA>TTA	p.S780L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.S780L|PCDHGA9_uc011dax.1_5'Flank|PCDHGA9_uc003lkh.1_5'Flank	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	780	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGGTGATTCATCTGGGGCC	0.403													97	79					0	0	0.000781405	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794330	140794330	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:140794330C>T	uc003lkl.1	+	1	1588	c.1588C>T	c.(1588-1590)CAT>TAT	p.H530Y	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.H530Y|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	530	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAGCAGTTTCATGAGCTACA	0.532													85	72					0	0	0.000781405	0	0
ARAP3	64411	broad.mit.edu	37	5	141033693	141033693	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:141033693G>A	uc003llm.2	-	33	4537	c.4459C>T	c.(4459-4461)CAG>TAG	p.Q1487*	ARAP3_uc003lll.2_Nonsense_Mutation_p.Q438*|ARAP3_uc011dbe.1_Nonsense_Mutation_p.Q1136*|ARAP3_uc003lln.2_Nonsense_Mutation_p.Q1318*	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1487	Pro-rich.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CTGAGCTCCTGGAGCAGCTGT	0.657													16	47					0	0	0.000566183	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142264942	142264942	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:142264942A>T	uc011dbj.1	+	5	499	c.464A>T	c.(463-465)AAG>ATG	p.K155M	ARHGAP26_uc003lmt.2_Missense_Mutation_p.K155M|ARHGAP26_uc003lmw.2_Missense_Mutation_p.K155M	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	155					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTTCCAAAAAGAAAGAATCT	0.358													18	42					0	0	0.00121646	0	0
KCTD16	57528	broad.mit.edu	37	5	143853416	143853416	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:143853416G>A	uc003lnm.1	+	4	1655	c.1026G>A	c.(1024-1026)CTG>CTA	p.L342L	KCTD16_uc003lnn.1_Silent_p.L342L	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	342						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TCCAGACTCTGGACCGTCCCA	0.587													23	48					0	0	0.000720815	0	0
SH3TC2	79628	broad.mit.edu	37	5	148422391	148422391	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:148422391G>A	uc003lpu.2	-	5	547	c.395C>T	c.(394-396)TCC>TTC	p.S132F	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lps.2_5'Flank|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Intron|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_Missense_Mutation_p.S17F	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	132							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGACACATGGATACGTAGCC	0.428													24	19					0	0	0.00127121	0	0
CSF1R	1436	broad.mit.edu	37	5	149435634	149435634	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:149435634C>T	uc003lrl.2	-	18	2704	c.2509G>A	c.(2509-2511)GAC>AAC	p.D837N	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.D837N	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	837	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	GACCAGACGTCGCTCTGAACC	0.612													10	33					0	0	0.000442599	0	0
CSF1R	1436	broad.mit.edu	37	5	149459714	149459714	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:149459714G>A	uc003lrl.2	-	3	688	c.493C>T	c.(493-495)CAC>TAC	p.H165Y	CSF1R_uc011dcd.1_Missense_Mutation_p.H17Y|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.H165Y|CSF1R_uc011dce.1_Missense_Mutation_p.H165Y|CSF1R_uc011dcf.1_Missense_Mutation_p.H165Y	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	165	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	TTGGCCCTGTGGATGGTGAAG	0.607													15	32					0	0	0.000308642	0	0
TCOF1	6949	broad.mit.edu	37	5	149754238	149754238	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:149754238C>T	uc003lry.2	+	9	1250	c.1142C>T	c.(1141-1143)TCC>TTC	p.S381F	TCOF1_uc003lrw.2_Missense_Mutation_p.S381F|TCOF1_uc011dch.1_Missense_Mutation_p.S381F|TCOF1_uc003lrz.2_Missense_Mutation_p.S381F|TCOF1_uc003lrx.2_Missense_Mutation_p.S304F|TCOF1_uc003lsa.2_Missense_Mutation_p.S304F|TCOF1_uc011dci.1_5'Flank	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	381					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCCAAGGAGTCCCCCAGGAAA	0.657													14	38					0	0	0.00244969	0	0
FAT2	2196	broad.mit.edu	37	5	150922028	150922028	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:150922028G>A	uc003lue.3	-	9	8673	c.8660C>T	c.(8659-8661)TCC>TTC	p.S2887F	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2887	Extracellular (Potential).|Cadherin 25.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCCTGAGAGGATAGCTGGAT	0.498													36	91					0	0	0.00058488	0	0
GALNT10	55568	broad.mit.edu	37	5	153755896	153755896	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:153755896C>T	uc003lvh.2	+	5	760	c.628C>T	c.(628-630)CGA>TGA	p.R210*	GALNT10_uc003lvg.1_Nonsense_Mutation_p.R210*|GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Intron	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	210	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GAGGATTCTTCGAACCAAGAA	0.502													32	58					0	0	0.00178596	0	0
KIF4B	285643	broad.mit.edu	37	5	154395457	154395457	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:154395457C>T	uc010jih.1	+	1	2198	c.2038C>T	c.(2038-2040)CGT>TGT	p.R680C		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	680	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGAACGAGACCGTAAGAGGCA	0.433													75	43					0	0	0.000781405	0	0
KIF4B	285643	broad.mit.edu	37	5	154396321	154396321	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:154396321G>A	uc010jih.1	+	1	3062	c.2902G>A	c.(2902-2904)GAA>AAA	p.E968K		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	968	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTGTCAGGATGAAGAACTTGA	0.478													24	38					0	0	0.00127121	0	0
TIMD4	91937	broad.mit.edu	37	5	156375464	156375464	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:156375464C>T	uc003lwh.2	-	5	864	c.807G>A	c.(805-807)TGG>TGA	p.W269*	TIMD4_uc010jii.2_Intron	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	269	Ser-rich.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CACTCGTTTTCCACATTGACA	0.348													70	145					0	0	0.000781405	0	0
CYFIP2	26999	broad.mit.edu	37	5	156816240	156816240	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:156816240G>C	uc003lwq.2	+	31	3389	c.3251G>C	c.(3250-3252)CGG>CCG	p.R1084P	CYFIP2_uc011ddn.1_Missense_Mutation_p.R1058P|CYFIP2_uc011ddo.1_Missense_Mutation_p.R888P|CYFIP2_uc003lwr.2_Missense_Mutation_p.R1084P|CYFIP2_uc003lws.2_Missense_Mutation_p.R1084P|CYFIP2_uc003lwt.2_Missense_Mutation_p.R987P|CYFIP2_uc011ddp.1_Missense_Mutation_p.R818P|CYFIP2_uc003lwv.2_Missense_Mutation_p.R39P	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1109					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCAAGGAGCGGCTGTGCTGT	0.607													128	103					0	0	0.000781405	0	0
CYFIP2	26999	broad.mit.edu	37	5	156817610	156817610	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:156817610C>T	uc003lwq.2	+	32	3666	c.3528C>T	c.(3526-3528)TTC>TTT	p.F1176F	CYFIP2_uc011ddn.1_Silent_p.F1150F|CYFIP2_uc011ddo.1_Silent_p.F980F|CYFIP2_uc003lwr.2_Silent_p.F1176F|CYFIP2_uc003lws.2_Silent_p.F1176F|CYFIP2_uc003lwt.2_Silent_p.F1079F|CYFIP2_uc011ddp.1_Silent_p.F910F|CYFIP2_uc003lwv.2_Silent_p.F131F	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	1201					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGACCTGTTCGACTTCTGTT	0.507													109	220					0	0	0.000781405	0	0
WWC1	23286	broad.mit.edu	37	5	167850869	167850869	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:167850869C>T	uc003lzu.2	+	11	1699	c.1606C>T	c.(1606-1608)CCA>TCA	p.P536S	WWC1_uc003lzv.2_Missense_Mutation_p.P536S|WWC1_uc011den.1_Missense_Mutation_p.P536S|WWC1_uc003lzw.2_Missense_Mutation_p.P335S	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	536					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CTCCCTATCCCCACGTTCCTC	0.622													27	25					0	0	0.000720815	0	0
SLIT3	6586	broad.mit.edu	37	5	168671773	168671773	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:168671773C>T	uc003mab.2	-	3	697	c.277G>A	c.(277-279)GAA>AAA	p.E93K	SLIT3_uc010jjg.2_Missense_Mutation_p.E93K|SLIT3_uc010jji.2_Missense_Mutation_p.E93K	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	93	LRR 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGTTGTCTTCCAGATGCCTA	0.517													10	25					0	0	0.00244969	0	0
DOCK2	1794	broad.mit.edu	37	5	169116293	169116293	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:169116293C>T	uc003maf.2	+	9	879	c.799C>T	c.(799-801)CCT>TCT	p.P267S	DOCK2_uc011der.1_RNA	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	267					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCGGGGCTTCCCTAAGGAGAT	0.498													26	21					0	0	0.00058488	0	0
RANBP17	64901	broad.mit.edu	37	5	170668034	170668034	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:170668034G>A	uc003mba.2	+	23	2541	c.2525G>A	c.(2524-2526)TGT>TAT	p.C842Y	RANBP17_uc003mbb.2_Missense_Mutation_p.C167Y|RANBP17_uc003mbd.2_Missense_Mutation_p.C205Y|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	842					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTGCCTTGTGTGGAAATTAT	0.448			T	TRD@	ALL								69	149					0	0	0.000781405	0	0
FAM153B	202134	broad.mit.edu	37	5	175530241	175530241	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:175530241G>A	uc003mdk.2	+	13	733	c.676G>A	c.(676-678)GAT>AAT	p.D226N		NM_001079529	NP_001072997	P0C7A2	F153B_HUMAN	hypothetical protein LOC202134	226										ovary(1)	1	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		TCTGATCAGGGATGTACTTCA	0.502													55	194					0	0	0.000781405	0	0
C5orf25	375484	broad.mit.edu	37	5	175716958	175716958	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:175716958C>A	uc003mds.3	+	4	781	c.374C>A	c.(373-375)CCA>CAA	p.P125Q	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Missense_Mutation_p.P144Q|uc003mdu.1_Missense_Mutation_p.P36Q			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	125											0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		GTAGGTCCCCCACCCGCTACA	0.498													10	47					1.96292e-10	6.70451e-10	0.00152264	1	0
TSPAN17	26262	broad.mit.edu	37	5	176084625	176084626	+	Missense_Mutation	DNP	CC	TT	TT	rs147674980	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:176084625_176084626CC>TT	uc003met.2	+	9	1154_1155	c.925_926CC>TT	c.(925-927)CCG>TTG	p.P309L	TSPAN17_uc003mes.3_3'UTR|TSPAN17_uc003meu.2_Missense_Mutation_p.P306L|TSPAN17_uc003mev.2_3'UTR|TSPAN17_uc003mew.2_3'UTR	NM_012171	NP_036303	Q96FV3	TSN17_HUMAN	transmembrane 4 superfamily member 17 isoform a	161	Extracellular (Potential).					integral to membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0	all_cancers(89;0.00141)|Renal(175;0.000269)|Lung NSC(126;0.00814)|all_lung(126;0.0133)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ggcccctggcccggccccaccc	0.168													6	20					0	0	6.4e-05	0	0
UNC5A	90249	broad.mit.edu	37	5	176306743	176306743	+	Silent	SNP	C	T	T	rs142194384		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:176306743C>T	uc003mey.2	+	15	2577	c.2385C>T	c.(2383-2385)TCC>TCT	p.S795S		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	795	Death.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTTTGCCTCCAAGCCCAGCC	0.701													36	35					0	0	0.00148497	0	0
FGFR4	2264	broad.mit.edu	37	5	176524556	176524556	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:176524556C>G	uc003mfl.2	+	18	2455	c.2288C>G	c.(2287-2289)CCC>CGC	p.P763R	FGFR4_uc003mfm.2_Missense_Mutation_p.P763R|FGFR4_uc011dfu.1_Missense_Mutation_p.P695R|FGFR4_uc003mfo.2_Missense_Mutation_p.P723R	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	763	Cytoplasmic (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	ACCTTCGGACCCTATTCCCCC	0.667										TSP Lung(9;0.080)			14	32					0	0	0.00244969	0	0
DDX41	51428	broad.mit.edu	37	5	176939793	176939793	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:176939793G>A	uc003mho.2	-	13	1408	c.1387C>T	c.(1387-1389)CAT>TAT	p.H463Y	DOK3_uc003mhi.3_5'Flank|DOK3_uc003mhj.3_5'Flank|DOK3_uc003mhk.2_5'Flank|DOK3_uc003mhl.2_5'Flank|DDX41_uc003mhm.2_Missense_Mutation_p.H243Y|DDX41_uc003mhn.2_Missense_Mutation_p.H332Y|DDX41_uc003mhp.2_Missense_Mutation_p.H332Y|DDX41_uc003mhq.1_Missense_Mutation_p.H243Y	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	463	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			TTGCCCCCATGGATGGCTACG	0.587													66	58					0	0	0.000781405	0	0
C5orf45	51149	broad.mit.edu	37	5	179269064	179269064	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:179269064C>T	uc003mla.2	-	5	336	c.292G>A	c.(292-294)GAA>AAA	p.E98K	C5orf45_uc003mky.2_Missense_Mutation_p.E95K|C5orf45_uc011dgt.1_Missense_Mutation_p.E98K|C5orf45_uc011dgu.1_Missense_Mutation_p.E43K|C5orf45_uc003mlc.2_Missense_Mutation_p.E43K|C5orf45_uc003mlb.2_5'UTR	NM_016175	NP_057259	Q6NTE8	CE045_HUMAN	hypothetical protein LOC51149 isoform 1	98											0						TGCGATTTTTCCTGCCAGATT	0.488													10	239					0	0	0.000673444	0	0
PRPF4B	8899	broad.mit.edu	37	6	4041016	4041016	+	Missense_Mutation	SNP	C	T	T	rs143126415		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:4041016C>T	uc003mvv.2	+	4	1514	c.1423C>T	c.(1423-1425)CGG>TGG	p.R475W	PRPF4B_uc003mvw.2_RNA|PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	475	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GGACAGAGGTCGGAGGAGCAG	0.333													19	90					0	0	0.00152264	0	0
F13A1	2162	broad.mit.edu	37	6	6266913	6266913	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:6266913G>A	uc003mwv.2	-	4	572	c.449C>T	c.(448-450)TCC>TTC	p.S150F	F13A1_uc011dib.1_Missense_Mutation_p.S87F	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	150					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	ACATTTGGGGGAAGACTGGAT	0.498													13	57					0	0	0.00136819	0	0
DSP	1832	broad.mit.edu	37	6	7569434	7569434	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:7569434G>A	uc003mxp.1	+	12	1714	c.1435G>A	c.(1435-1437)GGG>AGG	p.G479R	DSP_uc003mxq.1_Missense_Mutation_p.G479R	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	479	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CGTGCATAAGGGGGATGAGTG	0.468													32	116					0	0	0.000814825	0	0
DSP	1832	broad.mit.edu	37	6	7581406	7581406	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:7581406C>T	uc003mxp.1	+	23	5262	c.4983C>T	c.(4981-4983)GTC>GTT	p.V1661V	DSP_uc003mxq.1_Intron	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	1661	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTTCTGAGGTCGAGGCCCTGA	0.547													88	120					0	0	0.000781405	0	0
SNRNP48	154007	broad.mit.edu	37	6	7595265	7595265	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:7595265G>A	uc003mxr.2	+	4	396	c.337G>A	c.(337-339)GAC>AAC	p.D113N	SNRNP48_uc003mxs.2_RNA	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	113					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						GACAGATAAGGACTCACAATT	0.323													9	58					0	0	0.000673444	0	0
SNRNP48	154007	broad.mit.edu	37	6	7606287	7606287	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:7606287C>T	uc003mxr.2	+	8	889	c.830C>T	c.(829-831)TCA>TTA	p.S277L	SNRNP48_uc003mxs.2_RNA|SNRNP48_uc003mxt.1_Missense_Mutation_p.S29L	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	277					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						CGATCAGCTTCAGTAGATTCA	0.413													57	93					0	0	0.000781405	0	0
HIVEP1	3096	broad.mit.edu	37	6	12124382	12124382	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:12124382C>T	uc003nac.2	+	4	4533	c.4354C>T	c.(4354-4356)CAA>TAA	p.Q1452*	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	1452					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AACATCTTTCCAAAATACTGC	0.453													18	111					0	0	0.00152264	0	0
ATXN1	6310	broad.mit.edu	37	6	16326638	16326638	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:16326638T>C	uc003nbt.2	-	8	2875	c.1904A>G	c.(1903-1905)GAG>GGG	p.E635G	ATXN1_uc010jpi.2_Missense_Mutation_p.E635G|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	635	Interaction with USP7.|RNA-binding.|AXH.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGCTCGGTGCTCCCCGACGGC	0.577													27	51					0	0	0.00209593	0	0
CDKAL1	54901	broad.mit.edu	37	6	20546711	20546711	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:20546711C>A	uc003ndc.1	+	3	304	c.130C>A	c.(130-132)CAA>AAA	p.Q44K	CDKAL1_uc003ndd.1_Missense_Mutation_p.Q44K|CDKAL1_uc003nde.1_Silent_p.P11P|CDKAL1_uc010jpo.1_Missense_Mutation_p.Q44K|CDKAL1_uc003ndb.1_Missense_Mutation_p.Q44K	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	44					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			GCGAAATACCCAAAAATATTT	0.333													13	387					1.15088e-07	3.92095e-07	0.000422831	1	0
CDKAL1	54901	broad.mit.edu	37	6	20548862	20548863	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:20548862_20548863GG>TT	uc003ndc.1	+	4	386_387	c.212_213GG>TT	c.(211-213)TGG>TTT	p.W71F	CDKAL1_uc003ndd.1_Missense_Mutation_p.W71F|CDKAL1_uc003nde.1_Intron|CDKAL1_uc010jpo.1_Missense_Mutation_p.W71F|CDKAL1_uc003ndb.1_Missense_Mutation_p.W71F	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	71	MTTase N-terminal.				RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			ATACGAACATGGGGTTGTTCTC	0.287													11	558					0	0	6.4e-05	0	0
BTN2A1	11120	broad.mit.edu	37	6	26465416	26465416	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:26465416C>T	uc003nib.1	+	5	928	c.716C>T	c.(715-717)TCC>TTC	p.S239F	BTN2A1_uc003nic.1_Missense_Mutation_p.S239F|BTN2A1_uc003nid.1_Missense_Mutation_p.S87F|BTN2A1_uc011dko.1_Missense_Mutation_p.S178F|BTN2A1_uc010jqk.1_5'UTR	NM_007049	NP_008980	Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1 isoform 1	239	Extracellular (Potential).				lipid metabolic process	integral to plasma membrane				ovary(1)|skin(1)	2						TTTTCAGAATCCTTTATGCCC	0.478													49	68					0	0	0.000781405	0	0
BTN1A1	696	broad.mit.edu	37	6	26505394	26505394	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:26505394C>T	uc003nif.3	+	3	689	c.669C>T	c.(667-669)CTC>CTT	p.L223L		NM_001732	NP_001723	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1 precursor	223	Extracellular (Potential).|Ig-like V-type 2.					extracellular region|integral to plasma membrane	receptor activity			ovary(1)|skin(1)	2						TCCAGAATCTCCTTCTTGGCC	0.463													41	66					0	0	0.00285205	0	0
PGBD1	84547	broad.mit.edu	37	6	28268885	28268885	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28268885C>T	uc003nky.2	+	7	1624	c.1254C>T	c.(1252-1254)AAC>AAT	p.N418N	PGBD1_uc003nkz.2_Silent_p.N418N	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	418					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AAAAGTTGAACCCAGTAGAGC	0.358													40	86					0	0	0.00222228	0	0
ZNF323	64288	broad.mit.edu	37	6	28297142	28297142	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28297142C>T	uc003nla.2	-	2	719	c.319G>A	c.(319-321)GGG>AGG	p.G107R	ZNF323_uc003nld.2_Missense_Mutation_p.G107R|ZNF323_uc010jra.2_Missense_Mutation_p.G107R|ZNF323_uc003nlb.2_Intron|ZNF323_uc010jrb.2_Intron|ZNF323_uc003nlc.2_Missense_Mutation_p.G107R	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	107	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GCCTCCTCCCCACTCTCCGGA	0.537													105	120					0	0	0.000781405	0	0
GPX6	257202	broad.mit.edu	37	6	28474150	28474150	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28474150G>A	uc011dlj.1	-	4	348	c.298C>T	c.(298-300)CCC>TCC	p.P100S	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	100					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	TGGTTGCAGGGAAAGGCCAAC	0.498													39	50					0	0	0.00148497	0	0
GPX6	257202	broad.mit.edu	37	6	28483515	28483515	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28483515G>A	uc011dlj.1	-	1	56	c.6C>T	c.(4-6)TTC>TTT	p.F2F	GPX6_uc010jrg.1_RNA	NM_182701	NP_874360	P59796	GPX6_HUMAN	glutathione peroxidase 6 precursor	2					response to oxidative stress	extracellular region	glutathione peroxidase activity			ovary(3)|pancreas(1)|skin(1)	5					Glutathione(DB00143)	GGAACTGCTGGAACATGGCTA	0.537													18	25					0	0	0.00121646	0	0
SCAND3	114821	broad.mit.edu	37	6	28539923	28539923	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28539923G>A	uc003nlo.2	-	4	4361	c.3743C>T	c.(3742-3744)TCA>TTA	p.S1248L		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1248					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						tatccaaaatgaaggaagtga	0													34	43					0	0	0.00283554	0	0
SCAND3	114821	broad.mit.edu	37	6	28542428	28542428	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28542428C>T	uc003nlo.2	-	3	2672	c.2054G>A	c.(2053-2055)GGA>GAA	p.G685E		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	685					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TACCCAGTCTCCTACTTTGTC	0.398													63	83					0	0	0.000781405	0	0
SCAND3	114821	broad.mit.edu	37	6	28542663	28542663	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28542663C>T	uc003nlo.2	-	3	2437	c.1819G>A	c.(1819-1821)GAA>AAA	p.E607K		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	607					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CATTCTTTTTCACAAACTACA	0.418													28	26					0	0	0.00127121	0	0
SCAND3	114821	broad.mit.edu	37	6	28543477	28543477	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:28543477C>T	uc003nlo.2	-	3	1623	c.1005G>A	c.(1003-1005)AAG>AAA	p.K335K		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	335					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTGTGATGTTCTTGTATTTCG	0.368													101	101					0	0	0.000781405	0	0
OR2B3	442184	broad.mit.edu	37	6	29054742	29054742	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29054742G>A	uc003nlx.2	-	1	349	c.284C>T	c.(283-285)GCT>GTT	p.A95V		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						CACACAGCCAGCATAGCTGAT	0.453													47	61					0	0	0.000781405	0	0
OR14J1	442191	broad.mit.edu	37	6	29275415	29275415	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29275415G>A	uc011dln.1	+	1	949	c.949G>A	c.(949-951)GCC>ACC	p.A317T		NM_030946	NP_112208	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 5, subfamily U member	317	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						gtgcttaaaagccatgtttaa	0.294													25	38					0	0	0.000878237	0	0
OR12D3	81797	broad.mit.edu	37	6	29342848	29342848	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29342848A>C	uc003nme.2	-	1	221	c.217T>G	c.(217-219)TCA>GCA	p.S73A		NM_030959	NP_112221	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3						AGTGTCACTGAAGAATAAGAA	0.433													19	20					0	0	0.00152264	0	0
OR10C1	442194	broad.mit.edu	37	6	29407875	29407875	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29407875C>T	uc011dlp.1	+	1	83	c.83C>T	c.(82-84)TCT>TTT	p.S28F	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGCTCTTCTCTGTCTTTCTC	0.537													46	64					0	0	0.000680045	0	0
MAS1L	116511	broad.mit.edu	37	6	29455367	29455367	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29455367T>A	uc011dlq.1	-	1	313	c.313A>T	c.(313-315)ACG>TCG	p.T105S		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	105	Cytoplasmic (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						TAGGGATTCGTGGCCCCACAG	0.542													25	27					0	0	0.00047179	0	0
OR2H2	7932	broad.mit.edu	37	6	29556177	29556177	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29556177G>A	uc003nmr.1	+	1	495	c.456G>A	c.(454-456)GTG>GTA	p.V152V	GABBR1_uc003nmp.3_Intron	NM_007160	NP_009091	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H,	152	Helical; Name=4; (Potential).				defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTGGGCTAGTGGAGTCAGTGG	0.602													56	65					0	0	0.000781405	0	0
ZFP57	346171	broad.mit.edu	37	6	29640353	29640353	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29640353C>T	uc011dlw.1	-	4	1686	c.1535G>A	c.(1534-1536)AGG>AAG	p.R512K	ZFP57_uc003nnl.3_Missense_Mutation_p.R492K	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	428					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						GCCTCTTCTCCTGGGGGTATG	0.512													48	56					0	0	0.000781405	0	0
HLA-G	3135	broad.mit.edu	37	6	29797603	29797603	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:29797603C>T	uc003nnw.2	+	6	1084	c.906C>T	c.(904-906)TCC>TCT	p.S302S	HLA-G_uc011dmb.1_Silent_p.S274S|HLA-G_uc003raj.3_Silent_p.S307S|HLA-G_uc003nnz.3_Silent_p.S210S|HLA-G_uc010jrn.2_Silent_p.S118S|HLA-G_uc003nny.3_RNA|HLA-G_uc003ran.1_RNA	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	302	Extracellular (Potential).|Connecting peptide.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4						AGCAGTCTTCCCTGCCCACCA	0.582													36	38					0	0	0.000953801	0	0
MUC21	394263	broad.mit.edu	37	6	30954349	30954349	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:30954349A>G	uc003nsh.2	+	2	648	c.397A>G	c.(397-399)AGC>GGC	p.S133G	MUC21_uc003nsi.1_RNA	NM_001010909	NP_001010909	Q5SSG8	MUC21_HUMAN	mucin 21 precursor	133	Ser-rich.|7.|28 X 15 AA approximate tandem repeats.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(1)|skin(1)	2						CAGTGGGGCCAGCACAGCCAC	0.612													5	163					0	0	0.000602214	0	0
POU5F1	5460	broad.mit.edu	37	6	31138066	31138066	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31138066G>A	uc003nsv.2	-	1	386	c.332C>T	c.(331-333)TCC>TTC	p.S111F	uc011dng.1_RNA	NM_002701	NP_002692	Q01860	PO5F1_HUMAN	POU domain, class 5, transcription factor 1	111					anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	skin(7)|salivary_gland(2)|bone(2)|lung(1)|ovary(1)	13						GGGCTCCGGGGAGGCCCCATC	0.662			T	EWSR1	sarcoma								21	25					0	0	0.00152264	0	0
HCG27	253018	broad.mit.edu	37	6	31170627	31170627	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31170627C>T	uc011dni.1	+	2		c.602C>T				NR_026791				Homo sapiens cDNA FLJ40123 fis, clone TESTI2010280.												0						TGCCCCATCCCCAGGCTCTGG	0.532													56	52					0	0	0.000781405	0	0
BAT1	7919	broad.mit.edu	37	6	31503198	31503198	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31503198G>A	uc003ntt.2	-	6	1312	c.681C>T	c.(679-681)TTC>TTT	p.F227F	BAT1_uc003ntr.2_5'Flank|BAT1_uc003nts.2_Silent_p.F227F|BAT1_uc011dnn.1_Silent_p.F149F|BAT1_uc003ntu.2_Silent_p.F227F|BAT1_uc003ntv.2_Silent_p.F227F|BAT1_uc003ntw.2_Silent_p.F227F|BAT1_uc003ntx.2_Silent_p.F227F|BAT1_uc011dno.1_Silent_p.F180F|BAT1_uc011dnp.1_Silent_p.F149F	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	227	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						AGGTAGCACTGAACATCATGA	0.358													65	86					0	0	0.000781405	0	0
BAT1	7919	broad.mit.edu	37	6	31503225	31503225	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31503225G>A	uc003ntt.2	-	6	1285	c.654C>T	c.(652-654)ACC>ACT	p.T218T	BAT1_uc003ntr.2_5'Flank|BAT1_uc003nts.2_Silent_p.T218T|BAT1_uc011dnn.1_Silent_p.T140T|BAT1_uc003ntu.2_Silent_p.T218T|BAT1_uc003ntv.2_Silent_p.T218T|BAT1_uc003ntw.2_Silent_p.T218T|BAT1_uc003ntx.2_Silent_p.T218T|BAT1_uc011dno.1_Silent_p.T171T|BAT1_uc011dnp.1_Silent_p.T140T	NM_004640	NP_004631	Q13838	DX39B_HUMAN	HLA-B associated transcript 1	218	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding				0						TCTCGTGGGGGGTCATGCGAA	0.403													57	67					0	0	0.000781405	0	0
APOM	55937	broad.mit.edu	37	6	31625002	31625002	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31625002G>A	uc003nvl.2	+	3	343	c.270G>A	c.(268-270)ATG>ATA	p.M90I	APOM_uc003nvk.2_Missense_Mutation_p.M18I	NM_019101	NP_061974	O95445	APOM_HUMAN	apolipoprotein M	90					cholesterol efflux|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|negative regulation of plasma lipoprotein particle oxidation|reverse cholesterol transport	discoidal high-density lipoprotein particle|integral to plasma membrane|low-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	binding|lipid transporter activity				0						ACCTCTGCAGGAAAGATGGGC	0.453													115	181					0	0	0.000781405	0	0
SKIV2L	6499	broad.mit.edu	37	6	31928281	31928281	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31928281C>A	uc003nyn.1	+	5	816	c.427C>A	c.(427-429)CAG>AAG	p.Q143K	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|SKIV2L_uc011dou.1_5'UTR|SKIV2L_uc011dov.1_Intron	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	143						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GCCAGCCTCCCAGTCCTTATG	0.537													11	571					1.15088e-07	3.92095e-07	0.000422831	1	0
SKIV2L	6499	broad.mit.edu	37	6	31930846	31930846	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31930846C>T	uc003nyn.1	+	13	1770	c.1381C>T	c.(1381-1383)CTT>TTT	p.L461F	SKIV2L_uc011dou.1_Missense_Mutation_p.L303F|SKIV2L_uc011dov.1_Missense_Mutation_p.L268F	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	461	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CCCCAACGCCCTTGAGTTTGC	0.582													164	193					0	0	0.000781405	0	0
TNXB	7148	broad.mit.edu	37	6	31978766	31978766	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31978766G>A	uc011dpc.1	-	6	1632	c.723C>T	c.(721-723)CTC>CTT	p.L241L	STK19_uc003nza.2_5'Flank|STK19_uc003nzb.2_5'Flank	NM_032470	NP_115859	P22105	TENX_HUMAN	tenascin XB isoform 2	3857	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CTCCCACCTGGAGTTTCTGGG	0.637													65	117					0	0	0.000781405	0	0
C4A	720	broad.mit.edu	37	6	31996295	31996295	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:31996295G>A	uc011dpd.1	+	25	3267	c.3216G>A	c.(3214-3216)CGG>CGA	p.R1072R	C4A_uc011dpe.1_Silent_p.R1072R	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	1072					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						GGTTGTCACGGGGCAGCAGCA	0.627													39	38					0	0	0.00285205	0	0
TNXB	7148	broad.mit.edu	37	6	32032812	32032812	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:32032812G>A	uc003nzl.2	-	19	6829	c.6627C>T	c.(6625-6627)TCC>TCT	p.S2209S		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2281	Fibronectin type-III 15.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AGAGGCTGAGGGAGTCGGAGG	0.597													65	241					0	0	0.000781405	0	0
TNXB	7148	broad.mit.edu	37	6	32036709	32036710	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:32036709_32036710CG>AT	uc003nzl.2	-	16	5993_5994	c.5791_5792CG>AT	c.(5791-5793)CGG>ATG	p.R1931M		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2013	Fibronectin type-III 12.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GATGTCATTCCGGTCACCTCCT	0.525													10	639					0	0	6.4e-05	0	0
TNXB	7148	broad.mit.edu	37	6	32052409	32052410	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:32052409_32052410CG>AT	uc003nzl.2	-	8	3427_3428	c.3225_3226CG>AT	c.(3223-3228)TCCGAC>TCATAC	p.D1076Y		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1163	Fibronectin type-III 4.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AGCAAGGAGTCGGAGGTCCTGT	0.614													8	505					0	0	6.4e-05	0	0
C6orf10	10665	broad.mit.edu	37	6	32261633	32261633	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:32261633C>T	uc011dpy.1	-	12	990	c.817G>A	c.(817-819)GAG>AAG	p.E273K	C6orf10_uc011dpx.1_Missense_Mutation_p.E55K	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	273						integral to membrane				skin(1)	1						CTTTCTGGCTCCTTTATGTGT	0.398													96	102					0	0	0.000781405	0	0
HLA-DRB1	3123	broad.mit.edu	37	6	32549441	32549441	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:32549441C>G	uc003obp.3	-	3	588	c.545G>C	c.(544-546)TGG>TCG	p.W182S	HLA-DRB1_uc011dqa.1_Missense_Mutation_p.W12S|HLA-DRB5_uc003obk.3_Intron|HLA-DRB6_uc003obo.1_Intron|uc010jub.1_5'Flank|HLA-DRB1_uc011dqb.1_Missense_Mutation_p.W12S|HLA-DRB1_uc011dqc.1_Missense_Mutation_p.W12S	NM_002124	NP_002115	P01911	2B1F_HUMAN	major histocompatibility complex, class II, DR	182	Ig-like C1-type.|Beta-2.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex				skin(1)	1						CTGGAAGGTCCAGTCTCCATT	0.552									Rheumatoid_Arthritis|Sj_gren_syndrome	Multiple Myeloma(14;0.17)			10	94					0	0	0.00074312	0	0
TAP2	6891	broad.mit.edu	37	6	32805777	32805777	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:32805777G>A	uc003occ.2	-	1	265	c.234C>T	c.(232-234)TCC>TCT	p.S78S	TAP2_uc011dqf.1_Silent_p.S78S|TAP2_uc003ocb.1_Silent_p.S78S|TAP2_uc003ocd.2_Silent_p.S78S	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	78	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GGGCTCTCAGGGAGACAGTCA	0.687													22	32					0	0	0.00047179	0	0
HLA-DOA	3111	broad.mit.edu	37	6	32974859	32974859	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:32974859G>A	uc003ocr.2	-	4	823	c.747C>T	c.(745-747)CCC>CCT	p.P249P	HLA-DOA_uc010juj.2_Intron|HLA-DOA_uc010jui.2_3'UTR	NM_002119	NP_002110	P06340	DOA_HUMAN	major histocompatibility complex, class II, DO	249	Cytoplasmic (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endosome membrane|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity				0						CTCTGCACCTGGGGACACTGG	0.612													62	61					0	0	0.000781405	0	0
HLA-DPA1	3113	broad.mit.edu	37	6	33036820	33036820	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:33036820C>T	uc003ocs.1	-	3	635	c.604G>A	c.(604-606)GAC>AAC	p.D202N	HLA-DPA1_uc010juk.2_Missense_Mutation_p.D202N|HLA-DPA1_uc003oct.1_Missense_Mutation_p.D202N	NM_033554	NP_291032	P20036	DPA1_HUMAN	major histocompatibility complex, class II, DP	202	Alpha-2.|Ig-like C1-type.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			skin(1)	1						AGCGGCTGGTCCAAGCCCCAG	0.532													86	103					0	0	0.000781405	0	0
KIFC1	3833	broad.mit.edu	37	6	33372875	33372875	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:33372875C>T	uc003oef.3	+	7	1453	c.1003C>T	c.(1003-1005)CCC>TCC	p.P335S	KIFC1_uc011drf.1_Missense_Mutation_p.P327S	NM_002263	NP_002254	Q9BW19	KIFC1_HUMAN	kinesin family member C1	335	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity				0						CCTCCTGTTTCCCTCTGGCCC	0.677													54	72					0	0	0.000781405	0	0
GRM4	2914	broad.mit.edu	37	6	34101012	34101012	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:34101012G>A	uc003oir.3	-	1	432	c.262C>T	c.(262-264)CGC>TGC	p.R88C	GRM4_uc011dsn.1_Missense_Mutation_p.R88C|GRM4_uc010jvh.2_Missense_Mutation_p.R88C|GRM4_uc010jvi.2_5'UTR|GRM4_uc010jvk.1_Missense_Mutation_p.R7C	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	88	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	TTGTTGATGCGATCCAGGGCG	0.632													28	27					0	0	0.0024448	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34839369	34839369	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:34839369C>T	uc003oju.3	+	19	4224	c.3990C>T	c.(3988-3990)ATC>ATT	p.I1330I	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_RNA	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	1330										ovary(3)	3						AGGATGATATCCCCCCCATCT	0.517													37	26					0	0	0.00170553	0	0
BRPF3	27154	broad.mit.edu	37	6	36193062	36193062	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:36193062C>T	uc003olv.3	+	11	3424	c.3200C>T	c.(3199-3201)CCC>CTC	p.P1067L	BRPF3_uc010jwb.2_Missense_Mutation_p.P797L|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_Intron|BRPF3_uc011dtk.1_Missense_Mutation_p.P733L|BRPF3_uc010jwd.2_5'UTR	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1067					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CTCCTGCTGCCCTTTGAAGAC	0.652													9	25					0	0	0.000978159	0	0
BRPF3	27154	broad.mit.edu	37	6	36198362	36198362	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:36198362C>T	uc003olv.3	+	13	3818	c.3594C>T	c.(3592-3594)TCC>TCT	p.S1198S	BRPF3_uc010jwb.2_Silent_p.S928S|BRPF3_uc011dtj.1_RNA|BRPF3_uc010jwc.2_RNA|BRPF3_uc011dtk.1_Silent_p.S864S|BRPF3_uc010jwd.2_Silent_p.S100S	NM_015695	NP_056510	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1198					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GGCCCCACTCCTTCGTCACTT	0.632													20	25					0	0	0.00278032	0	0
FGD2	221472	broad.mit.edu	37	6	36988344	36988344	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:36988344C>T	uc010jwp.1	+	10	1321	c.1150C>T	c.(1150-1152)CCC>TCC	p.P384S	FGD2_uc003ong.2_Missense_Mutation_p.P106S|FGD2_uc011dtv.1_Missense_Mutation_p.P12S|FGD2_uc003onj.1_5'Flank	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	384	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						TGCTGAGTTTCCCCACTCCTT	0.647													12	10					0	0	0.00136819	0	0
BTBD9	114781	broad.mit.edu	37	6	38547997	38547997	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:38547997C>G	uc003ooa.3	-	6	1607	c.1031G>C	c.(1030-1032)AGC>ACC	p.S344T	BTBD9_uc003ony.3_Missense_Mutation_p.S276T|BTBD9_uc010jwv.2_Missense_Mutation_p.S276T|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.S344T	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	344					cell adhesion						0						CACTTACCGGCTATCTCGGTC	0.413													16	26					0	0	0.000422831	0	0
DNAH8	1769	broad.mit.edu	37	6	38813486	38813486	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:38813486C>A	uc003ooe.1	+	34	4931	c.4331C>A	c.(4330-4332)TCG>TAG	p.S1444*		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGAACCGAATCGGGAGAAATT	0.398													5	85					0.00198382	0.00668814	0.00198382	1	0
LRFN2	57497	broad.mit.edu	37	6	40360041	40360041	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:40360041C>T	uc003oph.1	-	3	2476	c.2011G>A	c.(2011-2013)GAG>AAG	p.E671K		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	671	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCAGCTCCTCCTTTCTCTGA	0.726													9	19					0	0	0.000442599	0	0
CCND3	896	broad.mit.edu	37	6	41904341	41904341	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:41904341C>T	uc003orn.2	-	4	832	c.667G>A	c.(667-669)GAT>AAT	p.D223N	CCND3_uc003orp.2_Missense_Mutation_p.D142N|CCND3_uc011duk.1_Missense_Mutation_p.D27N|CCND3_uc003orm.2_Missense_Mutation_p.D173N|CCND3_uc003oro.2_Missense_Mutation_p.D151N	NM_001760	NP_001751	P30281	CCND3_HUMAN	cyclin D3 isoform 2	223					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GTGAGCTCATCCCCGGACATG	0.582			T	IGH@	MM						OREG0017437	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	36					0	0	0.00121646	0	0
TRERF1	55809	broad.mit.edu	37	6	42236396	42236396	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:42236396C>T	uc003osd.2	-	5	1496	c.933G>A	c.(931-933)CAG>CAA	p.Q311Q	TRERF1_uc011duq.1_Silent_p.Q311Q|TRERF1_uc003osb.2_Silent_p.Q150Q|TRERF1_uc003osc.2_Silent_p.Q150Q|TRERF1_uc003ose.2_Silent_p.Q311Q	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	311	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			gcagctgtagctgctgcggct	0.433													47	46					0	0	0.000781405	0	0
KIAA0240	23506	broad.mit.edu	37	6	42796807	42796807	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:42796807C>T	uc003osn.1	+	6	887	c.736C>T	c.(736-738)CCA>TCA	p.P246S	KIAA0240_uc003osm.1_Missense_Mutation_p.P246S|KIAA0240_uc011duw.1_Missense_Mutation_p.P246S|KIAA0240_uc003oso.1_Missense_Mutation_p.P246S|KIAA0240_uc003osp.1_Missense_Mutation_p.P246S	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	246										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			GCAGCAAGCCCCATCAAATGT	0.443													40	63					0	0	0.00128727	0	0
KIAA0240	23506	broad.mit.edu	37	6	42833015	42833015	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:42833015C>T	uc003osn.1	+	13	3222	c.3071C>T	c.(3070-3072)CCC>CTC	p.P1024L	KIAA0240_uc011duw.1_Missense_Mutation_p.P1024L|KIAA0240_uc003osp.1_Missense_Mutation_p.P1024L	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	1024										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			GGACGGCAGCCCCAGAGTGAC	0.512													38	67					0	0	0.00195071	0	0
C6orf153	88745	broad.mit.edu	37	6	42992810	42992810	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:42992810G>A	uc003otp.1	+	2	226	c.218G>A	c.(217-219)AGT>AAT	p.S73N		NM_033112	NP_149103	Q96EU6	RRP36_HUMAN	hypothetical protein LOC88745	73					ribosomal small subunit biogenesis|rRNA processing	nucleolus					0			Colorectal(64;0.00237)|all cancers(41;0.0034)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0539)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCTGGAAATAGTCCTAAGAAA	0.453													36	29					0	0	0.000692331	0	0
CUL9	23113	broad.mit.edu	37	6	43166404	43166404	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:43166404C>T	uc003ouk.2	+	12	2936	c.2861C>T	c.(2860-2862)TCC>TTC	p.S954F	CUL9_uc003oul.2_Missense_Mutation_p.S954F|CUL9_uc010jyk.2_Missense_Mutation_p.S106F	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	954					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CTGATTCGATCCCTGGTTGGG	0.612													75	88					0	0	0.000781405	0	0
CUL9	23113	broad.mit.edu	37	6	43184064	43184064	+	Silent	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:43184064T>A	uc003ouk.2	+	31	6180	c.6105T>A	c.(6103-6105)GCT>GCA	p.A2035A	CUL9_uc003oul.2_Silent_p.A2007A|CUL9_uc010jyk.2_Silent_p.A1187A|CUL9_uc003oun.2_5'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	2035					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						ACTGGGGCGCTGAACAGCTGC	0.602													12	22					0	0	0.00136819	0	0
SLC22A7	10864	broad.mit.edu	37	6	43267216	43267216	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:43267216G>A	uc003out.2	+	3	587	c.488G>A	c.(487-489)GGA>GAA	p.G163E	SLC22A7_uc010jyl.1_Missense_Mutation_p.G161E|SLC22A7_uc003ous.2_Missense_Mutation_p.G161E	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	163	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GTGGCCTTTGGATATCTGTCC	0.567													50	47					0	0	0.000781405	0	0
ABCC10	89845	broad.mit.edu	37	6	43401062	43401062	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:43401062C>T	uc003ouy.1	+	3	1559	c.1344C>T	c.(1342-1344)AAC>AAT	p.N448N	ABCC10_uc003ouz.1_Silent_p.N405N|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	448	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TGGCCAGCAACCAGGAAATGC	0.597													8	18					0	0	0.000274275	0	0
ABCC10	89845	broad.mit.edu	37	6	43412958	43412958	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:43412958C>T	uc003ouy.1	+	14	3151	c.2936C>T	c.(2935-2937)TCC>TTC	p.S979F	ABCC10_uc003ouz.1_Missense_Mutation_p.S951F|ABCC10_uc010jyo.1_Missense_Mutation_p.S85F	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	979	ABC transmembrane type-1 2.|Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGTGTAAATTCCCTCTGCACC	0.587													33	43					0	0	0.000814825	0	0
MRPS18A	55168	broad.mit.edu	37	6	43639616	43639617	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:43639616_43639617GG>AA	uc003ovy.1	-	6	485_486	c.473_474CC>TT	c.(472-474)TCC>TTT	p.S158F	MRPS18A_uc003ovz.1_3'UTR|MRPS18A_uc003owa.1_Missense_Mutation_p.S232F	NM_018135	NP_060605	Q9NVS2	RT18A_HUMAN	mitochondrial ribosomal protein S18A precursor	158					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	all_cancers(18;6.56e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000479)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0102)|OV - Ovarian serous cystadenocarcinoma(102;0.137)			TGGGCTTGACGGAGCCAGGAGC	0.614													12	15					0	0	6.4e-05	0	0
SLC29A1	2030	broad.mit.edu	37	6	44199741	44199741	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:44199741G>A	uc003owu.1	+	10	1200	c.871G>A	c.(871-873)GTC>ATC	p.V291I	SLC29A1_uc003owv.1_Missense_Mutation_p.V291I|SLC29A1_uc003oww.1_Missense_Mutation_p.V370I|SLC29A1_uc003owx.1_Missense_Mutation_p.V291I|SLC29A1_uc003owy.1_Missense_Mutation_p.V291I|SLC29A1_uc003owz.1_Missense_Mutation_p.V291I	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	291	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	CTAGATCTCAGTCCTGGCTTT	0.453													24	33					0	0	0.00047179	0	0
GPR116	221395	broad.mit.edu	37	6	46851850	46851850	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:46851850A>C	uc003oyo.3	-	5	776	c.487T>G	c.(487-489)TTT>GTT	p.F163V	GPR116_uc003oyp.3_Missense_Mutation_p.F163V|GPR116_uc003oyq.3_Missense_Mutation_p.F163V|GPR116_uc003oyr.2_Missense_Mutation_p.F163V	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	163	SEA.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			AGCAGGCAAAAAGGTCCATTG	0.398													53	98					0	0	0.000781405	0	0
GPR115	221393	broad.mit.edu	37	6	47681990	47681990	+	Missense_Mutation	SNP	G	A	A	rs116696585	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:47681990G>A	uc003oza.1	+	6	1267	c.1009G>A	c.(1009-1011)GAA>AAA	p.E337K	GPR115_uc003oyz.1_Missense_Mutation_p.E394K|GPR115_uc003ozb.1_Missense_Mutation_p.E335K	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	337	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						ACTCACCTTCGAAAAGATCAA	0.453													49	48					0	0	0.000781405	0	0
OPN5	221391	broad.mit.edu	37	6	47754355	47754355	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:47754355G>A	uc003ozc.2	+	2	240	c.235G>A	c.(235-237)GAT>AAT	p.D79N	OPN5_uc003ozd.2_5'Flank	NM_181744	NP_859528	Q6U736	OPN5_HUMAN	opsin 5 isoform 1	79	Helical; Name=2; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			ovary(1)	1						AGCAGTCTGTGATCTGGGGAT	0.418													42	33					0	0	0.000781405	0	0
PGK2	5232	broad.mit.edu	37	6	49754528	49754528	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:49754528G>A	uc003ozu.2	-	1	480	c.373C>T	c.(373-375)CAT>TAT	p.H125Y		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	125					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					TCCTCCACATGAAAGCGCAGG	0.512													45	61					0	0	0.000781405	0	0
GCLC	2729	broad.mit.edu	37	6	53379056	53379056	+	Silent	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:53379056C>A	uc003pbw.1	-	6	1087	c.699G>T	c.(697-699)CCG>CCT	p.P233P	GCLC_uc003pbx.2_Silent_p.P233P	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	233					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding	p.P233P(1)		ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	AAATATGATCCGGCTTAGAAG	0.363													5	111					0.00198382	0.00668814	0.00198382	1	0
FAM83B	222584	broad.mit.edu	37	6	54805566	54805567	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:54805566_54805567CC>TT	uc003pck.2	+	5	1913_1914	c.1797_1798CC>TT	c.(1795-1800)ATCCCC>ATTTCC	p.P600S		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	600										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					CAGAATCAATCCCCAAGCTCCC	0.47													29	30					0	0	6.4e-05	0	0
FAM83B	222584	broad.mit.edu	37	6	54806494	54806494	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:54806494G>A	uc003pck.2	+	5	2841	c.2725G>A	c.(2725-2727)GAA>AAA	p.E909K		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	909										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TGTTACCCCTGAAAGAAGACC	0.458													41	44					0	0	0.0025221	0	0
FAM83B	222584	broad.mit.edu	37	6	54806498	54806498	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:54806498G>A	uc003pck.2	+	5	2845	c.2729G>A	c.(2728-2730)AGA>AAA	p.R910K		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	910										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					ACCCCTGAAAGAAGACCTACT	0.453													39	47					0	0	0.00128727	0	0
BMP5	653	broad.mit.edu	37	6	55659192	55659192	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:55659192C>T	uc003pcq.2	-	3	1429	c.717G>A	c.(715-717)AAG>AAA	p.K239K	BMP5_uc011dxf.1_Silent_p.K239K	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	239					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			AAGCTTGGGCCTTTCTTGTGT	0.373													57	79					0	0	0.000781405	0	0
BAI3	577	broad.mit.edu	37	6	70071332	70071332	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:70071332C>T	uc003pev.3	+	29	4615	c.4167C>T	c.(4165-4167)GCC>GCT	p.A1389A	BAI3_uc010kak.2_Silent_p.A1389A|BAI3_uc011dxx.1_Silent_p.A595A	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1389	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ATTTCATGGCCTCTGAGTTGG	0.418													49	16					0	0	0.000781405	0	0
COL12A1	1303	broad.mit.edu	37	6	75829093	75829093	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:75829093T>C	uc003phs.2	-	45	7349	c.7183A>G	c.(7183-7185)AGG>GGG	p.R2395G	COL12A1_uc003pht.2_Missense_Mutation_p.R1231G	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2395	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CCTCTGTACCTAATATTCTGG	0.438													3	84					0	0	6.4e-05	0	0
COL12A1	1303	broad.mit.edu	37	6	75855928	75855928	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:75855928C>T	uc003phs.2	-	24	4616	c.4450G>A	c.(4450-4452)GAT>AAT	p.D1484N	COL12A1_uc003pht.2_Missense_Mutation_p.D320N	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1484	Fibronectin type-III 10.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GGGCCAACATCATAAATATTC	0.453													24	6					0	0	0.000586117	0	0
TBX18	9096	broad.mit.edu	37	6	85470044	85470044	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:85470044G>A	uc003pkl.1	-	3	528	c.528C>T	c.(526-528)ATC>ATT	p.I176I	TBX18_uc010kbq.1_Silent_p.I18I	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	176	T-box.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		CTAATCCAGAGATCTTCACTC	0.393													19	5					0	0	0.00188189	0	0
GABRR1	2569	broad.mit.edu	37	6	89910970	89910970	+	Missense_Mutation	SNP	C	T	T	rs146686910	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:89910970C>T	uc003pna.2	-	3	643	c.188G>A	c.(187-189)CGA>CAA	p.R63Q	GABRR1_uc011dzv.1_Missense_Mutation_p.R40Q	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	63	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GTCAGGACTTCGTCTCAGAAT	0.453													44	8					0	0	0.000781405	0	0
MCHR2	84539	broad.mit.edu	37	6	100395740	100395740	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:100395740C>T	uc003pqh.1	-	3	605	c.290G>A	c.(289-291)GGA>GAA	p.G97E	MCHR2_uc003pqi.1_Missense_Mutation_p.G97E	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	97	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CACCCACTCTCCCCCTCGGGC	0.488													69	9					0	0	0.000781405	0	0
BVES	11149	broad.mit.edu	37	6	105563648	105563648	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:105563648C>T	uc003pqw.2	-	7	1028	c.871G>A	c.(871-873)GAA>AAA	p.E291K	BVES_uc003pqx.2_Missense_Mutation_p.E291K|BVES_uc003pqy.2_Missense_Mutation_p.E291K	NM_147147	NP_671488	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance isoform 5	291	Cytoplasmic (Potential).				epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity				0		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				TTCCTCATTTCCAACATGGAG	0.463													42	8					0	0	0.00170553	0	0
SOBP	55084	broad.mit.edu	37	6	107955662	107955662	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:107955662C>T	uc003prx.2	+	6	2118	c.1614C>T	c.(1612-1614)CCC>CCT	p.P538P		NM_018013	NP_060483	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog	538	Pro-rich.						metal ion binding			ovary(1)	1		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TGCCCATCCCCATCCCCATCC	0.667													17	2					0	0	0.000958276	0	0
SLC22A16	85413	broad.mit.edu	37	6	110763506	110763506	+	Missense_Mutation	SNP	G	A	A	rs146329765	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:110763506G>A	uc003puf.2	-	4	1191	c.1124C>T	c.(1123-1125)TCG>TTG	p.S375L	SLC22A16_uc003pue.2_Missense_Mutation_p.S356L	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	375	Helical; (Potential).				acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CAAGGAAAACGAGTAGAATCC	0.383													29	7					0	0	0.00106085	0	0
RFPL4B	442247	broad.mit.edu	37	6	112671178	112671178	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:112671178C>T	uc003pvx.1	+	3	580	c.268C>T	c.(268-270)CTC>TTC	p.L90F		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	90	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		GAGGGAGGAGCTCCGGCATTT	0.522													35	3					0	0	0.000953801	0	0
ROS1	6098	broad.mit.edu	37	6	117658463	117658463	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:117658463C>T	uc003pxp.1	-	31	5319	c.5120G>A	c.(5119-5121)AGC>AAC	p.S1707N	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1707	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AGGACCTTGGCTGCATGAAGT	0.323			T	GOPC|ROS1	glioblastoma|NSCLC								39	6					0	0	0.000680045	0	0
ROS1	6098	broad.mit.edu	37	6	117730773	117730773	+	Silent	SNP	C	T	T	rs149736013		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:117730773C>T	uc003pxp.1	-	4	460	c.261G>A	c.(259-261)GCG>GCA	p.A87A	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	87	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ATGCACCTTCCGCGCTGCTAC	0.473			T	GOPC|ROS1	glioblastoma|NSCLC								39	6					0	0	0.000781405	0	0
C6orf191	253582	broad.mit.edu	37	6	130164701	130164701	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:130164701G>A	uc003qbs.2	-	3	250	c.167C>T	c.(166-168)CCC>CTC	p.P56L		NM_001010876	NP_001010876	Q5VVB8	CF191_HUMAN	hypothetical protein LOC253582	56						integral to membrane				large_intestine(1)	1				GBM - Glioblastoma multiforme(226;0.0387)|all cancers(137;0.115)|OV - Ovarian serous cystadenocarcinoma(155;0.131)		GAGCCATGAGGGATTTGTTTT	0.303													62	9					0	0	0.000781405	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582477	136582477	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:136582477C>T	uc003qgx.1	-	12	2936	c.2683G>A	c.(2683-2685)GAT>AAT	p.D895N	BCLAF1_uc011edb.1_Missense_Mutation_p.D174N|BCLAF1_uc003qgw.1_Missense_Mutation_p.D722N|BCLAF1_uc003qgy.1_Missense_Mutation_p.D844N|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.D893N	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	895					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		ACAATCCCATCCCCTTGGTAT	0.403													19	196					0	0	0.00188189	0	0
MAP3K5	4217	broad.mit.edu	37	6	136980431	136980431	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:136980431G>A	uc003qhc.2	-	9	1813	c.1452C>T	c.(1450-1452)GCC>GCT	p.A484A	MAP3K5_uc011edj.1_5'Flank|MAP3K5_uc011edk.1_Silent_p.A329A|MAP3K5_uc010kgw.1_Silent_p.A484A	NM_005923	NP_005914	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase	484					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			ovary(2)|skin(2)|lung(1)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		CTAGGACGCTGGCCCCCAGAA	0.403													40	5					0	0	0.00170553	0	0
ECT2L	345930	broad.mit.edu	37	6	139186242	139186242	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:139186242C>T	uc003qif.1	+	10	1504	c.1401C>T	c.(1399-1401)ACC>ACT	p.T467T	ECT2L_uc011edq.1_Silent_p.T398T	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	467					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						TAGAAGAAACCTTGAAAACAG	0.483													31	7					0	0	0.00178596	0	0
SYNE1	23345	broad.mit.edu	37	6	152651188	152651188	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:152651188C>T	uc010kiw.2	-	78	15234	c.14632G>A	c.(14632-14634)GAA>AAA	p.E4878K	SYNE1_uc003qot.3_Missense_Mutation_p.E4807K|SYNE1_uc003qou.3_Missense_Mutation_p.E4878K|SYNE1_uc010kiz.2_Missense_Mutation_p.E633K	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4878	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCTCACATTCTGTCACCGTC	0.537										HNSCC(10;0.0054)			31	5					0	0	0.000692331	0	0
MAS1	4142	broad.mit.edu	37	6	160328212	160328212	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:160328212C>T	uc003qsz.2	+	1	239	c.225C>T	c.(223-225)ATC>ATT	p.I75I		NM_002377	NP_002368	P04201	MAS_HUMAN	MAS1 oncogene	75	Helical; Name=2; (Potential).				anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			ovary(2)|lung(2)	4		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		ACCTGTCTATCGCAGACATCT	0.438													102	14					0	0	0.000781405	0	0
SLC22A1	6580	broad.mit.edu	37	6	160575853	160575853	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:160575853C>T	uc003qtc.2	+	9	1514	c.1409C>T	c.(1408-1410)TCC>TTC	p.S470F	SLC22A1_uc003qtd.2_Intron	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	470	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		ATGGTGTGTTCCTCCCTGTGT	0.428													28	7					0	0	0.00209593	0	0
LPAL2	80350	broad.mit.edu	37	6	160908435	160908435	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:160908435G>A	uc003qtj.2	-	4		c.538C>T			LPAL2_uc011efy.1_RNA	NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		CGAACAATCCGGATTCCTGCA	0.493													18	4					0	0	0.000958276	0	0
LPA	4018	broad.mit.edu	37	6	161006193	161006193	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr6:161006193C>T	uc003qtl.2	-	27	4294	c.4174G>A	c.(4174-4176)GAT>AAT	p.D1392N		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3900	Kringle 35.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CTCTGTCCATCACCTCGGTAG	0.463													106	10					0	0	0.000781405	0	0
MICALL2	79778	broad.mit.edu	37	7	1482056	1482056	+	Missense_Mutation	SNP	G	A	A	rs148942886		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:1482056G>A	uc003skj.3	-	7	1630	c.1483C>T	c.(1483-1485)CCC>TCC	p.P495S	MICALL2_uc003ski.3_5'UTR	NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	495						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		TTGGCTAAGGGACTTGCTTGT	0.607													87	168					0	0	0.000781405	0	0
IQCE	23288	broad.mit.edu	37	7	2638195	2638195	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:2638195C>T	uc003smo.3	+	17	1721	c.1537C>T	c.(1537-1539)CCC>TCC	p.P513S	IQCE_uc010ksm.1_Missense_Mutation_p.P513S|IQCE_uc003sml.1_Missense_Mutation_p.P513S|IQCE_uc011jvy.1_Missense_Mutation_p.P497S|IQCE_uc011jvz.1_Missense_Mutation_p.P448S|IQCE_uc003smk.3_Missense_Mutation_p.P497S|IQCE_uc003smn.3_Missense_Mutation_p.P448S	NM_152558	NP_689771	Q6IPM2	IQCE_HUMAN	IQ motif containing E isoform 1	513											0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		GCCCCGCTCCCCCTGCTCTGA	0.706													35	35					0	0	0.00283554	0	0
AMZ1	155185	broad.mit.edu	37	7	2749363	2749363	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:2749363G>A	uc003smr.1	+	6	1222	c.861G>A	c.(859-861)GAG>GAA	p.E287E	AMZ1_uc003sms.1_Missense_Mutation_p.G231S|AMZ1_uc011jwa.1_Silent_p.E36E	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	287							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		GCCTGGACGAGGCCCTGCGGC	0.667											OREG0017838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	27					0	0	0.00278032	0	0
SDK1	221935	broad.mit.edu	37	7	4051763	4051763	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:4051763G>A	uc003smx.2	+	16	2455	c.2316G>A	c.(2314-2316)CCG>CCA	p.P772P	SDK1_uc010kso.2_Silent_p.P48P	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	772	Fibronectin type-III 2.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTGCTCCCCCGAAAAATATAG	0.522													103	115					0	0	0.000781405	0	0
PAPOLB	56903	broad.mit.edu	37	7	4900726	4900726	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:4900726G>A	uc003snk.2	-	1	900	c.716C>T	c.(715-717)TCC>TTC	p.S239F	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	238					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		TAATATATTGGAATAGATATT	0.443													65	65					0	0	0.000781405	0	0
TNRC18	84629	broad.mit.edu	37	7	5428882	5428882	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:5428882G>A	uc003soi.3	-	5	922	c.573C>T	c.(571-573)TCC>TCT	p.S191S	TNRC18_uc010ksx.1_Silent_p.S117S	NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	191							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GGGCGCCCGAGGAGTGGCCGC	0.751													7	8					0	0	0.00198382	0	0
ACTB	60	broad.mit.edu	37	7	5568857	5568857	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:5568857C>T	uc003sos.3	-	2	334	c.298G>A	c.(298-300)GAG>AAG	p.E100K	ACTB_uc003sor.3_5'UTR|ACTB_uc003sot.3_Missense_Mutation_p.E100K|ACTB_uc003soq.3_5'UTR|ACTB_uc010ksy.2_Intron	NM_001101	NP_001092	P60709	ACTB_HUMAN	beta actin	100					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton				0		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		ACGGGGTGCTCCTCGGGAGCC	0.627													35	38					0	0	0.000814825	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6084289	6084289	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:6084289G>A	uc003spp.2	-	7	780	c.634C>T	c.(634-636)CTA>TTA	p.L212L	EIF2AK1_uc003spq.2_Silent_p.L212L|EIF2AK1_uc011jwm.1_Silent_p.L88L|EIF2AK1_uc003spr.1_Silent_p.L4L	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	212	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		ACTTCCCGTAGGACCTAGAAA	0.443													30	37					0	0	0.00209593	0	0
RPA3	6119	broad.mit.edu	37	7	7676679	7676679	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:7676679G>A	uc003sri.2	-	8	1490	c.318C>T	c.(316-318)ATC>ATT	p.I106I	RPA3_uc003srh.2_Silent_p.I67I	NM_002947	NP_002938	P35244	RFA3_HUMAN	replication protein A3, 14kDa	106					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	cytoplasm|DNA replication factor A complex|nucleoplasm	protein binding|single-stranded DNA binding			large_intestine(1)	1		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.202)		GGAAGTCATGGATAATTTTCA	0.294								Direct_reversal_of_damage|NER					90	128					0	0	0.000781405	0	0
ICA1	3382	broad.mit.edu	37	7	8178486	8178486	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:8178486C>T	uc003srm.2	-	12	1111	c.1044G>A	c.(1042-1044)ATG>ATA	p.M348I	ICA1_uc010ktr.2_Missense_Mutation_p.M377I|ICA1_uc003srl.2_Missense_Mutation_p.M336I|ICA1_uc003srn.3_Missense_Mutation_p.M274I|ICA1_uc003srp.3_Missense_Mutation_p.M347I|ICA1_uc010kts.2_Intron|ICA1_uc003srq.2_Missense_Mutation_p.M348I|ICA1_uc003srr.2_Missense_Mutation_p.M347I|ICA1_uc003sro.3_Missense_Mutation_p.M348I	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	348					neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CCTCAGATTTCATGTCTAATA	0.279													67	74					0	0	0.000781405	0	0
HDAC9	9734	broad.mit.edu	37	7	19015469	19015469	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:19015469G>A	uc003sui.2	+	24	3104	c.3063G>A	c.(3061-3063)AGG>AGA	p.R1021R	HDAC9_uc003sue.2_Silent_p.R1018R|HDAC9_uc003suj.2_Silent_p.R977R|HDAC9_uc003suk.2_Silent_p.R266R	NM_178425	NP_848512	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 5	Error:Variant_position_missing_in_Q9UKV0_after_alignment					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CTGTGCCAAGGGGCTGTGCTC	0.478													17	34					0	0	0.000958276	0	0
ABCB5	340273	broad.mit.edu	37	7	20698167	20698167	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:20698167G>A	uc003suw.3	+	5	786	c.240G>A	c.(238-240)ATG>ATA	p.M80I	ABCB5_uc010kuh.2_Missense_Mutation_p.M525I|ABCB5_uc003suv.3_Missense_Mutation_p.M80I|ABCB5_uc011jyi.1_Missense_Mutation_p.M80I	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	80	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GAGCTCAAATGAGTGGAGGGC	0.423													32	36					0	0	0.000692331	0	0
DNAH11	8701	broad.mit.edu	37	7	21657337	21657337	+	Missense_Mutation	SNP	A	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:21657337A>C	uc003svc.2	+	23	4242	c.4211A>C	c.(4210-4212)GAG>GCG	p.E1404A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1404	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GCCATCACAGAGTTACAGAGC	0.517									Kartagener_syndrome				22	23					0	0	0.00278032	0	0
CDCA7L	55536	broad.mit.edu	37	7	21942717	21942717	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:21942717G>A	uc010kuk.2	-	9	1333	c.1213C>T	c.(1213-1215)CCC>TCC	p.P405S	CDCA7L_uc003sve.3_Missense_Mutation_p.P371S|CDCA7L_uc010kul.2_Missense_Mutation_p.P359S|CDCA7L_uc003svf.3_Missense_Mutation_p.P404S	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	405					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						CCACGACAGGGGGGACACACC	0.517													12	29					0	0	0.00244969	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22259571	22259571	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:22259571C>T	uc003svg.2	-	9	764	c.451G>A	c.(451-453)GGA>AGA	p.G151R		NM_012294	NP_036426	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	Error:Variant_position_missing_in_Q92565_after_alignment					nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			ovary(1)	1						TCAATTCGTCCGATTTCATCT	0.438													16	28					0	0	0.000422831	0	0
CLK2P	1197	broad.mit.edu	37	7	23624973	23624973	+	Missense_Mutation	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:23624973C>A	uc003swk.2	-	1	1174	c.524G>T	c.(523-525)CGG>CTG	p.R175L		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						TCGGATCATCCGGGAAGGGAT	0.478													5	75					3.59834e-05	0.00012218	0.00116845	1	0
JAZF1	221895	broad.mit.edu	37	7	27872513	27872514	+	Missense_Mutation	DNP	CC	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:27872513_27872514CC>AA	uc003szn.2	-	5	878_879	c.637_638GG>TT	c.(637-639)GGG>TTG	p.G213L	JAZF1_uc003szm.2_Missense_Mutation_p.G149L	NM_175061	NP_778231	Q86VZ6	JAZF1_HUMAN	JAZF zinc finger 1	213	C2H2-type 3; degenerate.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcriptional repressor complex	nucleic acid binding|transcription corepressor activity|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131						GTAACTCTTCCCACAGCGACAC	0.47			T	SUZ12	endometrial stromal tumours								14	719					0	0	6.4e-05	0	0
SCRN1	9805	broad.mit.edu	37	7	29966239	29966239	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:29966239G>T	uc010kvp.2	-	6	1119	c.915C>A	c.(913-915)TTC>TTA	p.F305L	SCRN1_uc011jzy.1_Missense_Mutation_p.F237L|SCRN1_uc003tak.2_Missense_Mutation_p.F305L|SCRN1_uc011jzz.1_Missense_Mutation_p.F305L|SCRN1_uc011kaa.1_Missense_Mutation_p.F325L|SCRN1_uc011jzw.1_Missense_Mutation_p.F172L|SCRN1_uc011jzx.1_Missense_Mutation_p.F128L	NM_001145515	NP_001138987	Q12765	SCRN1_HUMAN	secernin 1 isoform c	305					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			ovary(2)	2						TGAAAGGCTTGAATATGGACC	0.512													27	34					4.22769e-11	1.44461e-10	0.00106085	1	0
TBX20	57057	broad.mit.edu	37	7	35288414	35288414	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:35288414C>T	uc011kas.1	-	3	431	c.420G>A	c.(418-420)GTG>GTA	p.V140V		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	140	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						CCTCAGGATCCACCCCCGAAA	0.547													22	34					0	0	0.00047179	0	0
TXNDC3	51314	broad.mit.edu	37	7	37916593	37916593	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:37916593C>T	uc003tfn.2	+	12	1350	c.978C>T	c.(976-978)CTC>CTT	p.L326L		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	326	NDK 2.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						GACCAAATCTCTTTCATGAAA	0.303									Kartagener_syndrome				24	30					0	0	0.00127121	0	0
AMPH	273	broad.mit.edu	37	7	38433665	38433665	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:38433665G>A	uc003tgu.2	-	18	1617	c.1548C>T	c.(1546-1548)ACC>ACT	p.T516T	AMPH_uc003tgv.2_Silent_p.T474T|AMPH_uc003tgt.2_Silent_p.T401T|AMPH_uc003tgw.1_Silent_p.T539T|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	516					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CACCCTCAGTGGTTTCAGTTC	0.602													64	85					0	0	0.000781405	0	0
CAMK2B	816	broad.mit.edu	37	7	44283092	44283092	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:44283092C>T	uc003tkq.2	-	7	659	c.449G>A	c.(448-450)GGG>GAG	p.G150E	CAMK2B_uc003tkp.2_Missense_Mutation_p.G150E|CAMK2B_uc003tkx.2_Missense_Mutation_p.G150E|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Missense_Mutation_p.G150E|CAMK2B_uc003tks.2_Missense_Mutation_p.G150E|CAMK2B_uc003tku.2_Missense_Mutation_p.G150E|CAMK2B_uc003tkv.2_Missense_Mutation_p.G150E|CAMK2B_uc003tkt.2_Missense_Mutation_p.G150E|CAMK2B_uc003tkw.2_Missense_Mutation_p.G150E|CAMK2B_uc010kyc.2_Missense_Mutation_p.G150E	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	150	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						CACTGCAGCCCCTTTGCACTT	0.607													25	56					0	0	0.000720815	0	0
CAMK2B	816	broad.mit.edu	37	7	44323761	44323761	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:44323761C>T	uc003tkq.2	-	2	339	c.129G>A	c.(127-129)AAG>AAA	p.K43K	CAMK2B_uc003tkp.2_Silent_p.K43K|CAMK2B_uc003tkx.2_Silent_p.K43K|CAMK2B_uc010kyd.2_RNA|CAMK2B_uc003tkr.2_Silent_p.K43K|CAMK2B_uc003tks.2_Silent_p.K43K|CAMK2B_uc003tku.2_Silent_p.K43K|CAMK2B_uc003tkv.2_Silent_p.K43K|CAMK2B_uc003tkt.2_Silent_p.K43K|CAMK2B_uc003tkw.2_Silent_p.K43K|CAMK2B_uc010kyc.2_Silent_p.K43K	NM_001220	NP_001211	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II	43	Protein kinase.	ATP (By similarity).			interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)|ovary(1)	2						TGTTGATGATCTTGGCTGCAT	0.582													9	15					0	0	0.000673444	0	0
OGDH	4967	broad.mit.edu	37	7	44714019	44714019	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:44714019G>A	uc003tln.2	+	7	907	c.798G>A	c.(796-798)GAG>GAA	p.E266E	OGDH_uc003tlm.2_Silent_p.E266E|OGDH_uc011kbx.1_Silent_p.E262E|OGDH_uc011kby.1_Silent_p.E116E|OGDH_uc003tlp.2_Silent_p.E277E|OGDH_uc011kbz.1_Silent_p.E61E|OGDH_uc003tlo.1_Silent_p.E99E	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	266					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	GGTTTGAGGAGTTCCTACAGC	0.453													54	51					0	0	0.000781405	0	0
ADCY1	107	broad.mit.edu	37	7	45632475	45632475	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:45632475C>T	uc003tne.3	+	2	775	c.757C>T	c.(757-759)CGA>TGA	p.R253*	ADCY1_uc003tnd.2_Nonsense_Mutation_p.R28*	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	253	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CATTGAGGACCGACTGAGGCT	0.597													40	35					0	0	0.000953801	0	0
ADCY1	107	broad.mit.edu	37	7	45743207	45743207	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:45743207C>T	uc003tne.3	+	16	2598	c.2580C>T	c.(2578-2580)TAC>TAT	p.Y860Y		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	860	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGGACCTCTACTACCAGTCCT	0.582													31	36					0	0	0.00178596	0	0
TNS3	64759	broad.mit.edu	37	7	47408318	47408318	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:47408318G>A	uc003tnv.2	-	17	2292	c.1925C>T	c.(1924-1926)GCT>GTT	p.A642V	TNS3_uc003tnw.2_Missense_Mutation_p.A642V	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	642						focal adhesion	protein binding			ovary(4)	4						CCTCTGGACAGCCACCCTACT	0.657													38	63					0	0	0.00111076	0	0
POM121L12	285877	broad.mit.edu	37	7	53104243	53104243	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:53104243C>T	uc003tpz.2	+	1	895	c.879C>T	c.(877-879)CCC>CCT	p.P293P		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	293											0						CTGCTGGCCCCTTTGGCTCCT	0.607													23	31					0	0	0.000720815	0	0
EGFR	1956	broad.mit.edu	37	7	55266528	55266528	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:55266528C>T	uc003tqk.2	+	23	3066	c.2820C>T	c.(2818-2820)ACC>ACT	p.T940T	EGFR_uc010kzg.1_Silent_p.T895T|EGFR_uc011kco.1_Silent_p.T887T	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	940	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCATATGTACCATCGATGTCT	0.537		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			31	31					0	0	0.00209593	0	0
VOPP1	81552	broad.mit.edu	37	7	55560112	55560112	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:55560112C>T	uc003tqs.2	-	4	375	c.192_splice	c.e4-1	p.W64_splice	VOPP1_uc003tqq.2_Splice_Site_p.W55_splice|VOPP1_uc010kzh.2_Splice_Site_p.W61_splice|VOPP1_uc010kzi.2_Splice_Site_p.W47_splice|VOPP1_uc011kcr.1_Splice_Site	NM_030796	NP_110423	Q96AW1	VOPP1_HUMAN	EGFR-coamplified and overexpressed protein						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity				0						CAGAAGGAACCTGAGGAGAGT	0.637													6	14					0	0	0.00116845	0	0
VOPP1	81552	broad.mit.edu	37	7	55588791	55588791	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:55588791G>A	uc003tqs.2	-	2	270	c.87C>T	c.(85-87)TTC>TTT	p.F29F	VOPP1_uc003tqq.2_Silent_p.F20F|VOPP1_uc010kzh.2_Silent_p.F26F|VOPP1_uc010kzi.2_Silent_p.F12F|VOPP1_uc011kcr.1_5'UTR	NM_030796	NP_110423	Q96AW1	VOPP1_HUMAN	EGFR-coamplified and overexpressed protein	29	Extracellular (Potential).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic vesicle membrane|endosome|integral to organelle membrane	signal transducer activity				0						AGAGTCCTTCGAAATACCAGC	0.398													4	4					0	0	0.000602214	0	0
C7orf42	55069	broad.mit.edu	37	7	66410104	66410104	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:66410104C>T	uc003tvk.2	+	3	565	c.301C>T	c.(301-303)CCC>TCC	p.P101S	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Missense_Mutation_p.P101S	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	101						integral to membrane				ovary(1)	1						CACCCAGTCCCCCCAGGCCCT	0.572													34	49					0	0	0.00058488	0	0
WBSCR17	64409	broad.mit.edu	37	7	70800709	70800709	+	Missense_Mutation	SNP	C	T	T	rs146773920	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:70800709C>T	uc003tvy.2	+	2	412	c.412C>T	c.(412-414)CGT>TGT	p.R138C	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	138	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TCCGGATTATCGTCCCACCAA	0.463													29	59					0	0	0.001512	0	0
WBSCR22	114049	broad.mit.edu	37	7	73108352	73108353	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:73108352_73108353CC>TT	uc003tyt.2	+	10	731_732	c.673_674CC>TT	c.(673-675)CCC>TTC	p.P225F	WBSCR22_uc010lbi.1_RNA|WBSCR22_uc003tyu.2_Missense_Mutation_p.P225F|WBSCR22_uc003tyv.2_Missense_Mutation_p.P187F|WBSCR22_uc003tyw.1_Missense_Mutation_p.P88F	NM_017528	NP_059998	O43709	WBS22_HUMAN	Williams Beuren syndrome chromosome region 22	225						nucleus	methyltransferase activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				TGAAGTTGAACCCAGGGAGTCT	0.545													25	94					0	0	6.4e-05	0	0
ELN	2006	broad.mit.edu	37	7	73477977	73477977	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:73477977G>A	uc003tzw.2	+	29	2054	c.1963G>A	c.(1963-1965)GGA>AGA	p.G655R	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Missense_Mutation_p.G649R|ELN_uc003tzz.2_Missense_Mutation_p.G568R|ELN_uc003tzo.2_Missense_Mutation_p.G601R|ELN_uc003tzp.2_Missense_Mutation_p.G560R|ELN_uc003tzq.2_Missense_Mutation_p.G513R|ELN_uc003tzr.2_RNA|ELN_uc003tzs.2_Missense_Mutation_p.G630R|ELN_uc003tzt.2_Missense_Mutation_p.G654R|ELN_uc003tzu.2_Missense_Mutation_p.G635R|ELN_uc003tzv.2_Missense_Mutation_p.G620R|ELN_uc003tzx.2_Missense_Mutation_p.G639R|ELN_uc011kff.1_Missense_Mutation_p.G649R|ELN_uc003tzy.2_Missense_Mutation_p.G625R	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	711	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	TGGGCTCGGAGGACTCGGAGT	0.582			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						57	130					0	0	0.000781405	0	0
POM121C	100101267	broad.mit.edu	37	7	75052288	75052288	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:75052288G>A	uc003udk.3	-	13	2132	c.1247C>T	c.(1246-1248)ACC>ATC	p.T416I		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	658	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						TGCTTGAAGGGTTGGAGGTGC	0.602													71	30					0	0	0.000781405	0	0
DTX2	113878	broad.mit.edu	37	7	76112063	76112063	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:76112063C>T	uc003uff.3	+	5	1063	c.507C>T	c.(505-507)TGC>TGT	p.C169C	DTX2_uc011kgk.1_Silent_p.C78C|DTX2_uc003ufg.3_Silent_p.C169C|DTX2_uc003ufh.3_Silent_p.C169C|DTX2_uc003ufj.3_Silent_p.C169C	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	169	WWE 2.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCAGCTTCTGCCGCAGCGTGC	0.652													17	27					0	0	0.000422831	0	0
LOC100132832	100132832	broad.mit.edu	37	7	76669317	76669317	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:76669317C>T	uc003ufy.2	+	1		c.521C>T			PMS2L11_uc011kgn.1_RNA	NR_028058				Homo sapiens cDNA FLJ59034 complete cds, moderately similar to Protein deltex-2.												0						GTCAGTCCATCAGATTTGCTC	0.413													41	142					0	0	0.000781405	0	0
CCDC146	57639	broad.mit.edu	37	7	76924180	76924180	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:76924180C>T	uc003uga.2	+	19	2992	c.2865C>T	c.(2863-2865)ATC>ATT	p.I955I	CCDC146_uc010ldp.2_Silent_p.I669I|CCDC146_uc003ugc.2_Silent_p.I292I	NM_020879	NP_065930	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	955										ovary(1)|central_nervous_system(1)	2		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				CAGTTGAAATCTGAATATGTG	0.403													12	27					0	0	0.00185496	0	0
PCLO	27445	broad.mit.edu	37	7	82451921	82451921	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:82451921C>T	uc003uhx.2	-	20	14970	c.14681G>A	c.(14680-14682)GGA>GAA	p.G4894E	PCLO_uc003uhv.2_Missense_Mutation_p.G4894E|PCLO_uc003uht.1_Missense_Mutation_p.G336E|PCLO_uc003uhu.1_Missense_Mutation_p.G315E	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4756	Ser-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCGAGATGGTCCATGAGAACG	0.532													284	90					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82476562	82476562	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:82476562C>T	uc003uhx.2	-	11	13945	c.13656G>A	c.(13654-13656)GGG>GGA	p.G4552G	PCLO_uc003uhv.2_Silent_p.G4552G|PCLO_uc003uht.1_Silent_p.G3G|PCLO_uc003uhu.1_5'UTR	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATACTTGCATCCCTAGAAAGA	0.353													20	6					0	0	0.00188189	0	0
PCLO	27445	broad.mit.edu	37	7	82544905	82544905	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:82544905G>A	uc003uhx.2	-	7	12686	c.12397C>T	c.(12397-12399)CGT>TGT	p.R4133C	PCLO_uc003uhv.2_Missense_Mutation_p.R4133C|PCLO_uc010lec.2_Missense_Mutation_p.R1098C	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4064					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCCCTCTACGAAATTCCTGT	0.408													93	30					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82545449	82545449	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:82545449C>T	uc003uhx.2	-	7	12142	c.11853G>A	c.(11851-11853)CAG>CAA	p.Q3951Q	PCLO_uc003uhv.2_Silent_p.Q3951Q|PCLO_uc010lec.2_Silent_p.Q916Q	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3882	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTGAAGGTAACTGATAAGAAG	0.438													92	417					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82579186	82579186	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:82579186G>A	uc003uhx.2	-	6	11007	c.10718C>T	c.(10717-10719)TCA>TTA	p.S3573L	PCLO_uc003uhv.2_Missense_Mutation_p.S3573L|PCLO_uc010lec.2_Missense_Mutation_p.S538L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3504					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTGTGTGTCTGAATCTGCTTC	0.453													57	69					0	0	0.000781405	0	0
PCLO	27445	broad.mit.edu	37	7	82584101	82584101	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:82584101C>T	uc003uhx.2	-	5	6457	c.6168G>A	c.(6166-6168)AGG>AGA	p.R2056R	PCLO_uc003uhv.2_Silent_p.R2056R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1987					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTAGTAGTTTCCTTTCTTCTT	0.448													15	84					0	0	0.00244969	0	0
ABCB1	5243	broad.mit.edu	37	7	87175237	87175237	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:87175237C>T	uc003uiz.1	-	16	2247	c.1829G>A	c.(1828-1830)GGA>GAA	p.G610E	ABCB1_uc011khc.1_Missense_Mutation_p.G546E	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	610	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATCATGATTTCCTTTCTCCAC	0.398													18	87					0	0	0.000566183	0	0
DBF4	10926	broad.mit.edu	37	7	87537294	87537295	+	Missense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:87537294_87537295CG>AT	uc003ujf.1	+	12	2345_2346	c.1841_1842CG>AT	c.(1840-1842)CCG>CAT	p.P614H	DBF4_uc003ujh.1_Missense_Mutation_p.P354H|DBF4_uc003ujg.1_Missense_Mutation_p.P390H|DBF4_uc011khf.1_Missense_Mutation_p.P381H	NM_006716	NP_006707	Q9UBU7	DBF4A_HUMAN	activator of S phase kinase	614					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	enzyme activator activity|nucleic acid binding|protein binding|zinc ion binding			lung(2)	2	Esophageal squamous(14;0.00202)	Breast(660;0.0334)				TGTAGTTCACCGGTACAGTCTT	0.322													6	129					0	0	6.4e-05	0	0
C7orf63	79846	broad.mit.edu	37	7	89891300	89891300	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:89891300C>T	uc010lep.2	+	4	537	c.286C>T	c.(286-288)CTG>TTG	p.L96L	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_5'UTR|C7orf63_uc011khj.1_Silent_p.L96L|C7orf63_uc010leo.2_Silent_p.L96L	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	96							binding			ovary(1)	1						AATTCTGAATCTGTGTTCAGG	0.244													22	87					0	0	0.000720815	0	0
AKAP9	10142	broad.mit.edu	37	7	91714954	91714954	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:91714954C>T	uc003ulg.2	+	36	9203	c.8978C>T	c.(8977-8979)TCT>TTT	p.S2993F	AKAP9_uc003ulf.2_Missense_Mutation_p.S2985F|AKAP9_uc003uli.2_Missense_Mutation_p.S2616F|AKAP9_uc003ulj.2_Missense_Mutation_p.S763F|AKAP9_uc003ulk.2_Missense_Mutation_p.S268F	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2997					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACAATCTCATCTCTAAAGGAT	0.333			T	BRAF	papillary thyroid								23	41					0	0	0.00047179	0	0
SAMD9	54809	broad.mit.edu	37	7	92731876	92731876	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:92731876C>T	uc003umf.2	-	3	3791	c.3535G>A	c.(3535-3537)GAA>AAA	p.E1179K	SAMD9_uc003umg.2_Missense_Mutation_p.E1179K	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1179						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TACAATCTTTCCTTCACTTCA	0.373													179	66					0	0	0.000781405	0	0
COL1A2	1278	broad.mit.edu	37	7	94049548	94049548	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:94049548G>A	uc003ung.1	+	35	2554	c.2083G>A	c.(2083-2085)GAA>AAA	p.E695K	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	695			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	ATTATAGGGCGAAGCTGGGGc	0.408										HNSCC(75;0.22)			34	108					0	0	0.00209593	0	0
PON1	5444	broad.mit.edu	37	7	94928282	94928282	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:94928282G>A	uc003uns.2	-	9	1139	c.1042C>T	c.(1042-1044)CAC>TAC	p.H348Y	PON1_uc011kih.1_Missense_Mutation_p.H348Y	NM_000446	NP_000437	P27169	PON1_HUMAN	paraoxonase 1 precursor	348					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			pancreas(1)	1	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AGAGCTTTGTGAAACACTGTG	0.463													17	90					0	0	0.00074312	0	0
NPTX2	4885	broad.mit.edu	37	7	98249027	98249027	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:98249027G>A	uc003upl.2	+	2	676	c.499G>A	c.(499-501)GGG>AGG	p.G167R		NM_002523	NP_002514	P47972	NPTX2_HUMAN	neuronal pentraxin II precursor	167					synaptic transmission	extracellular region	metal ion binding|sugar binding			central_nervous_system(2)|skin(1)	3	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GCAGCGGCTGGGGGAGCTGGA	0.657													40	74					0	0	0.00170553	0	0
TRRAP	8295	broad.mit.edu	37	7	98575900	98575900	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:98575900C>T	uc003upp.2	+	56	8640	c.8431C>T	c.(8431-8433)CCT>TCT	p.P2811S	TRRAP_uc011kis.1_Missense_Mutation_p.P2793S|TRRAP_uc003upr.2_Missense_Mutation_p.P2510S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2811	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TAACGCCTCCCCTGCTATTTT	0.418													20	119					0	0	0.00121646	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100000181	100000181	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:100000181G>A	uc003uut.2	-	16	1677	c.1429C>T	c.(1429-1431)CGT>TGT	p.R477C	ZCWPW1_uc011kjq.1_Missense_Mutation_p.R357C|ZCWPW1_uc003uur.2_Intron|ZCWPW1_uc003uus.2_Missense_Mutation_p.R357C|ZCWPW1_uc011kjr.1_Intron|ZCWPW1_uc011kjp.1_Intron	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	477							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACTCGCTTACGAATGGGCAAA	0.433													96	430					0	0	0.000781405	0	0
TFR2	7036	broad.mit.edu	37	7	100229759	100229759	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:100229759G>A	uc003uvv.1	-	7	953	c.912C>T	c.(910-912)TTC>TTT	p.F304F	TFR2_uc010lhc.1_5'UTR|TFR2_uc003uvu.1_Silent_p.F133F	NM_003227	NP_003218	Q9UP52	TFR2_HUMAN	transferrin receptor 2	304	Extracellular (Potential).				cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			ovary(1)|pancreas(1)	2	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GGTCCTGGGAGAAGTCCGCTG	0.602													48	96					0	0	0.000781405	0	0
ZAN	7455	broad.mit.edu	37	7	100391482	100391482	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:100391482G>A	uc003uwj.2	+	44	7993	c.7828G>A	c.(7828-7830)GAC>AAC	p.D2610N	ZAN_uc003uwk.2_Intron|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_Intron|ZAN_uc010lhi.2_Intron|ZAN_uc011kke.1_Intron	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	2610	Extracellular (Potential).				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGAGCTGTATGACACCCTGCC	0.632													22	97					0	0	0.000586117	0	0
EPHB4	2050	broad.mit.edu	37	7	100417782	100417782	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:100417782G>A	uc003uwn.1	-	5	1436	c.945C>T	c.(943-945)CCC>CCT	p.P315P	EPHB4_uc003uwm.1_Silent_p.P222P|EPHB4_uc010lhj.1_Silent_p.P315P|EPHB4_uc011kkf.1_Silent_p.P315P|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Silent_p.P315P	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	315	Extracellular (Potential).|Cys-rich.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTGCACCCCGGGGGTCTGTGC	0.637													92	30					0	0	0.000781405	0	0
MUC17	140453	broad.mit.edu	37	7	100676940	100676940	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:100676940C>T	uc003uxp.1	+	3	2296	c.2243C>T	c.(2242-2244)CCA>CTA	p.P748L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	748	Extracellular (Potential).|Ser-rich.|10.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGAAGCACTCCATTAACAAGT	0.488													84	338					0	0	0.000781405	0	0
MUC17	140453	broad.mit.edu	37	7	100679937	100679937	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:100679937G>A	uc003uxp.1	+	3	5293	c.5240G>A	c.(5239-5241)GGA>GAA	p.G1747E	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1747	Extracellular (Potential).|59 X approximate tandem repeats.|27.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTAGTGAAGGAACCACTCCA	0.512													149	244					0	0	0.000781405	0	0
TRIM56	81844	broad.mit.edu	37	7	100732634	100732634	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:100732634C>T	uc003uxq.2	+	3	2272	c.2041C>T	c.(2041-2043)CCG>TCG	p.P681S	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	681					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					TGGCTGCCAGCCGGGCTCCGT	0.587													91	32					0	0	0.000781405	0	0
CUX1	1523	broad.mit.edu	37	7	101844695	101844695	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:101844695C>T	uc003uyx.3	+	18	2156	c.2118C>T	c.(2116-2118)ATC>ATT	p.I706I	CUX1_uc003uys.3_Silent_p.I717I|CUX1_uc003uyt.2_Intron|CUX1_uc011kkn.1_Intron|CUX1_uc003uyw.2_Intron|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Intron	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	706	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						ATGACGCCATCCGCTCCATCC	0.657													39	125					0	0	0.00148497	0	0
SPDYE6	729597	broad.mit.edu	37	7	101988921	101988921	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:101988921G>T	uc011kkp.1	-	6	1373	c.952C>A	c.(952-954)CGT>AGT	p.R318S	SPDYE6_uc003uzb.2_Missense_Mutation_p.R174S	NM_001146210	NP_001139682	P0CI01	SPDE6_HUMAN	speedy homolog E6	318	Arg-rich.										0						TTCGTGGAACGGTATAACTGG	0.572													16	488					0.000175454	0.000593749	0.00152264	1	0
DNAJC2	27000	broad.mit.edu	37	7	102956221	102956221	+	Silent	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:102956221T>C	uc003vbo.2	-	15	1877	c.1626A>G	c.(1624-1626)GAA>GAG	p.E542E	PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_Silent_p.E167E|DNAJC2_uc010lix.2_Silent_p.E489E|DNAJC2_uc003vbp.2_Silent_p.E167E	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	542					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						CTTCAAATCGTTCTGAAGGCG	0.383													72	22					0	0	0.000781405	0	0
MLL5	55904	broad.mit.edu	37	7	104752740	104752740	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:104752740G>A	uc003vcm.2	+	27	5071	c.4537G>A	c.(4537-4539)GCA>ACA	p.A1513T	MLL5_uc010ljc.2_Missense_Mutation_p.A1513T|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.A247T	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1513	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TACTCAGCAGGCAACTTCTGG	0.478													84	36					0	0	0.000781405	0	0
RINT1	60561	broad.mit.edu	37	7	105205745	105205745	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:105205745G>A	uc003vda.1	+	13	2139	c.1908G>A	c.(1906-1908)CAG>CAA	p.Q636Q	RINT1_uc010ljj.1_Silent_p.Q211Q|EFCAB10_uc003vdb.2_3'UTR|uc003vdd.1_5'Flank	NM_021930	NP_068749	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	636	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			ovary(3)|central_nervous_system(1)	4						TGCCATCTCAGTCAGAGCAGG	0.403													19	94					0	0	0.00121646	0	0
PIK3CG	5294	broad.mit.edu	37	7	106508517	106508517	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:106508517G>A	uc003vdv.3	+	2	596	c.511G>A	c.(511-513)GAT>AAT	p.D171N	PIK3CG_uc003vdu.2_Missense_Mutation_p.D171N|PIK3CG_uc003vdw.2_Missense_Mutation_p.D171N	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	171					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CGTGCACGACGATGAGCTGGA	0.677													14	61					0	0	0.00185496	0	0
SLC26A3	1811	broad.mit.edu	37	7	107408085	107408085	+	Missense_Mutation	SNP	T	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:107408085T>G	uc003ver.2	-	20	2421	c.2210A>C	c.(2209-2211)AAA>ACA	p.K737T	SLC26A3_uc003ves.2_Missense_Mutation_p.K624T	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	737					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						TTTTCCATCTTTTTCCTGAGA	0.328													41	13					0	0	0.00148497	0	0
LAMB1	3912	broad.mit.edu	37	7	107601006	107601006	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:107601006G>A	uc003vew.2	-	18	2533	c.2198C>T	c.(2197-2199)ACC>ATC	p.T733I	LAMB1_uc003vev.2_Missense_Mutation_p.T757I|LAMB1_uc003vex.2_Missense_Mutation_p.T733I	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	733	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCTGAAAGGTTTCCCAGGC	0.458													35	88					0	0	0.000814825	0	0
LAMB1	3912	broad.mit.edu	37	7	107626734	107626734	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:107626734G>A	uc003vew.2	-	6	833	c.498C>T	c.(496-498)TTC>TTT	p.F166F	LAMB1_uc003vev.2_Silent_p.F190F|LAMB1_uc003vex.2_Silent_p.F166F|LAMB1_uc010ljn.1_Silent_p.F252F	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	166	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTCATAGGCGAAGTATCTAT	0.448													43	96					0	0	0.000781405	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519373	113519373	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:113519373C>T	uc010ljy.1	-	4	1805	c.1774G>A	c.(1774-1776)GAA>AAA	p.E592K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	592					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ACAGCTTCTTCCCAACTTAAA	0.468													21	115					0	0	0.00278032	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558349	113558349	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:113558349C>T	uc010ljy.1	-	1	734	c.703G>A	c.(703-705)GAA>AAA	p.E235K		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	235					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GGCTCTTGTTCTTTCTTTTGA	0.333													47	170					0	0	0.000781405	0	0
KCND2	3751	broad.mit.edu	37	7	119915781	119915781	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:119915781C>T	uc003vjj.1	+	1	2060	c.1095C>T	c.(1093-1095)ATC>ATT	p.I365I		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	365					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GGTATACCATCGTCACCATGA	0.507													12	79					0	0	0.00244969	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121612675	121612675	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:121612675C>T	uc003vjy.2	+	4	780	c.385C>T	c.(385-387)CAC>TAC	p.H129Y	PTPRZ1_uc003vjz.2_Missense_Mutation_p.H129Y	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	129	Extracellular (Potential).|Alpha-carbonic anhydrase.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GATAACTTTTCACTGGGGAAA	0.363													62	108					0	0	0.000781405	0	0
CADPS2	93664	broad.mit.edu	37	7	122091457	122091457	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:122091457G>A	uc010lkp.2	-	14	2422	c.2259C>T	c.(2257-2259)TCC>TCT	p.S753S	CADPS2_uc011knx.1_Silent_p.S124S|CADPS2_uc003vkg.3_Silent_p.S450S|CADPS2_uc010lkq.2_Silent_p.S750S	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	753					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						TTTCTAAAAGGGAAGAGAGTC	0.303													13	39					0	0	0.00185496	0	0
SLC13A1	6561	broad.mit.edu	37	7	122787360	122787360	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:122787360G>A	uc003vkm.2	-	7	690	c.665C>T	c.(664-666)TCA>TTA	p.S222L	SLC13A1_uc010lks.2_Missense_Mutation_p.S98L	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	222						integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	TCTCATGCCTGAGTTCTGTTC	0.308													10	21					0	0	0.00136819	0	0
HYAL4	23553	broad.mit.edu	37	7	123508568	123508568	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:123508568A>G	uc003vlc.2	+	3	879	c.241A>G	c.(241-243)AAG>GAG	p.K81E	HYAL4_uc011knz.1_Missense_Mutation_p.K81E	NM_012269	NP_036401	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	81	Extracellular (Potential).				fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			skin(1)	1						CCCACTGGCCAAGGCCAGGGG	0.403													81	35					0	0	0.000781405	0	0
SPAM1	6677	broad.mit.edu	37	7	123594319	123594319	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:123594319C>T	uc003vld.2	+	4	1097	c.695C>T	c.(694-696)CCC>CTC	p.P232L	SPAM1_uc003vle.2_Missense_Mutation_p.P232L|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Missense_Mutation_p.P232L|SPAM1_uc010lku.2_Missense_Mutation_p.P232L	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	232					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	TATAAGAAACCCGGTTACAAT	0.368													42	86					0	0	0.00170553	0	0
SPAM1	6677	broad.mit.edu	37	7	123599999	123599999	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:123599999C>T	uc003vld.2	+	6	1908	c.1506C>T	c.(1504-1506)ATC>ATT	p.I502I	SPAM1_uc003vle.2_Intron|SPAM1_uc011koa.1_Intron|SPAM1_uc003vlf.3_Silent_p.I502I|SPAM1_uc010lku.2_Silent_p.I502I	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	502					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	TGTTTCTTATCATTTCTTCTG	0.353													20	72					0	0	0.00278032	0	0
FLNC	2318	broad.mit.edu	37	7	128483517	128483517	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:128483517G>A	uc003vnz.3	+	18	2906	c.2697G>A	c.(2695-2697)AAG>AAA	p.K899K	FLNC_uc003voa.3_Silent_p.K899K	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	899	Filamin 7.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GAGCCGGCAAGGCCAAGCTGG	0.582													17	37					0	0	0.00074312	0	0
SMO	6608	broad.mit.edu	37	7	128845484	128845484	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:128845484C>T	uc003vor.2	+	4	1061	c.781C>T	c.(781-783)CGC>TGC	p.R261C	SMO_uc003vos.2_5'Flank	NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	261	Cytoplasmic (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						GAACTCGAATCGCTACCCTGC	0.537			Mis		skin basal cell 								58	116					0	0	0.000781405	0	0
CPA5	93979	broad.mit.edu	37	7	129987662	129987662	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:129987662G>A	uc010lmd.1	+	5	792	c.172G>A	c.(172-174)GAT>AAT	p.D58N	CPA5_uc003vps.2_Missense_Mutation_p.D58N|CPA5_uc003vpt.2_Missense_Mutation_p.D58N|CPA5_uc010lme.1_Missense_Mutation_p.D58N|CPA5_uc003vpu.1_Missense_Mutation_p.D58N	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	58					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					ACTTCTCGGGGATCTGGAGGG	0.577													9	38					0	0	0.00136819	0	0
CPA5	93979	broad.mit.edu	37	7	130007368	130007368	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:130007368C>T	uc010lmd.1	+	12	1614	c.994C>T	c.(994-996)CCT>TCT	p.P332S	CPA5_uc003vps.2_Missense_Mutation_p.P332S|CPA5_uc003vpt.2_Missense_Mutation_p.P332S|CPA5_uc010lme.1_Missense_Mutation_p.P332S|CPA5_uc003vpu.1_Missense_Mutation_p.P332S|uc003vpv.1_RNA	NM_001127441	NP_001120913	Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5 isoform 1	332					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2	Melanoma(18;0.0435)					GCTTATGTACCCTTACGGCCG	0.542													44	94					0	0	0.000781405	0	0
PLXNA4	91584	broad.mit.edu	37	7	131817886	131817886	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:131817886G>A	uc003vra.3	-	31	5740	c.5511C>T	c.(5509-5511)TCC>TCT	p.S1837S	PLXNA4_uc003vqz.3_Silent_p.S122S	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1837	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGTGCATCCGGGACTGCTCAG	0.517													26	92					0	0	0.000720815	0	0
PLXNA4	91584	broad.mit.edu	37	7	131870132	131870132	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:131870132G>A	uc003vra.3	-	16	3313	c.3084C>T	c.(3082-3084)ATC>ATT	p.I1028I		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1028	IPT/TIG 2.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GGTCCTGGTGGATCTTGGCCC	0.557													24	94					0	0	0.000720815	0	0
AKR1B10	57016	broad.mit.edu	37	7	134221440	134221440	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:134221440C>T	uc003vrr.2	+	5	788	c.468C>T	c.(466-468)GCC>GCT	p.A156A		NM_020299	NP_064695	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10	156					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			skin(5)	5						TGGTGAAAGCCCTTGGGGTCT	0.493													36	113					0	0	0.00058488	0	0
CHRM2	1129	broad.mit.edu	37	7	136700447	136700447	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:136700447G>A	uc003vtf.1	+	4	1458	c.835G>A	c.(835-837)GAG>AAG	p.E279K	CHRM2_uc003vtg.1_Missense_Mutation_p.E279K|CHRM2_uc003vtj.1_Missense_Mutation_p.E279K|CHRM2_uc003vtk.1_Missense_Mutation_p.E279K|CHRM2_uc003vtl.1_Missense_Mutation_p.E279K|CHRM2_uc003vtm.1_Missense_Mutation_p.E279K|CHRM2_uc003vti.1_Missense_Mutation_p.E279K|CHRM2_uc003vto.1_Missense_Mutation_p.E279K|CHRM2_uc003vtn.1_Missense_Mutation_p.E279K|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	279	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	TCAGGGAGAGGAGAAGGAGAG	0.488													18	57					0	0	0.000958276	0	0
DGKI	9162	broad.mit.edu	37	7	137284623	137284623	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:137284623C>T	uc003vtt.2	-	11	1197	c.1196G>A	c.(1195-1197)TGG>TAG	p.W399*	DGKI_uc003vtu.2_Nonsense_Mutation_p.W99*	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	399	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						ATTCAGGTACCACATGAACAT	0.373													8	60					0	0	0.000673444	0	0
AKR1D1	6718	broad.mit.edu	37	7	137790090	137790090	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:137790090C>T	uc003vtz.2	+	5	563	c.494C>T	c.(493-495)TCC>TTC	p.S165F	AKR1D1_uc011kqb.1_Missense_Mutation_p.S165F|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_RNA|AKR1D1_uc011kqe.1_Missense_Mutation_p.S165F|AKR1D1_uc011kqf.1_Intron|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	165					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						TTGGTGAAATCCCTGGGAGTG	0.483													48	183					0	0	0.000781405	0	0
KIAA1549	57670	broad.mit.edu	37	7	138591708	138591708	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:138591708C>T	uc011kql.1	-	6	3466	c.3417G>A	c.(3415-3417)GAG>GAA	p.E1139E	KIAA1549_uc003vuk.3_Silent_p.E1089E|KIAA1549_uc011kqj.1_Silent_p.E1139E	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1139						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						AGAAACTGAACTCCACCACAC	0.532			O	BRAF	pilocytic astrocytoma								30	68					0	0	0.000692331	0	0
PARP12	64761	broad.mit.edu	37	7	139724499	139724499	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:139724499G>A	uc003vvl.1	-	12	2841	c.1967C>T	c.(1966-1968)TCC>TTC	p.S656F	PARP12_uc003vvk.1_Missense_Mutation_p.S442F|PARP12_uc010lnf.1_RNA	NM_022750	NP_073587	Q9H0J9	PAR12_HUMAN	poly ADP-ribose polymerase 12	656	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)	3	Melanoma(164;0.0142)					GGAGGGGTCGGACACACTGTT	0.577													14	110					0	0	0.000422831	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				69	28					0	0	0.000781405	0	0
KIAA1147	57189	broad.mit.edu	37	7	141385329	141385329	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141385329G>A	uc003vwk.2	-	3	476	c.476C>T	c.(475-477)CCC>CTC	p.P159L		NM_001080392	NP_001073861	A4D1U4	LCHN_HUMAN	hypothetical protein LOC57189	159										ovary(1)	1	Melanoma(164;0.0171)					TGTGTAGGAGGGAGAGAGGAT	0.602													23	145					0	0	0.000878237	0	0
PRSS37	136242	broad.mit.edu	37	7	141536973	141536973	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141536973C>T	uc003vws.1	-	4	878	c.506G>A	c.(505-507)GGA>GAA	p.G169E	PRSS37_uc011krk.1_Missense_Mutation_p.G156E|PRSS37_uc011krl.1_Missense_Mutation_p.G168E|PRSS37_uc003vwt.1_Missense_Mutation_p.G156E	NM_001008270	NP_001008271	A4D1T9	PRS37_HUMAN	protease, serine, 37 precursor	169	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			skin(1)	1						GTGGCTTTTTCCTTGTTCTGT	0.433													23	115					0	0	0.00278032	0	0
OR9A4	130075	broad.mit.edu	37	7	141619558	141619558	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141619558G>A	uc003vwu.1	+	1	883	c.883G>A	c.(883-885)GAT>AAT	p.D295N		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CCTCCGGAATGATAAAGTCAT	0.458													84	33					0	0	0.000781405	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673474	141673474	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141673474G>A	uc003vwx.1	-	1	100	c.16C>T	c.(16-18)CGC>TGC	p.R6C		NM_176817	NP_789787	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	6	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|skin(1)	2	Melanoma(164;0.0171)					GTGCGGATGCGAGTTAGAGTC	0.448													18	99					0	0	0.00074312	0	0
MGAM	8972	broad.mit.edu	37	7	141747669	141747669	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141747669G>A	uc003vwy.2	+	22	2637	c.2583G>A	c.(2581-2583)ACG>ACA	p.T861T		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	861	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ATGGGGAAACGAAGGGTGAGC	0.458													9	14					0	0	0.000274275	0	0
MGAM	8972	broad.mit.edu	37	7	141752244	141752244	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141752244G>A	uc003vwy.2	+	25	3010	c.2956G>A	c.(2956-2958)GAG>AAG	p.E986K		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	986	Lumenal (Potential).|P-type 2.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTGTATCTGGGAGGTAACCAT	0.433													7	41					0	0	0.000442599	0	0
MGAM	8972	broad.mit.edu	37	7	141754673	141754673	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141754673G>A	uc003vwy.2	+	27	3333	c.3279G>A	c.(3277-3279)GGG>GGA	p.G1093G		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1093	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ATCCATTTGGGATTGAAATTC	0.493													21	107					0	0	0.00152264	0	0
MGAM	8972	broad.mit.edu	37	7	141759293	141759293	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141759293G>A	uc003vwy.2	+	32	3895	c.3841G>A	c.(3841-3843)GAC>AAC	p.D1281N		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1281	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTCAGACATCGACTACATGGA	0.567													17	30					0	0	0.000958276	0	0
MGAM	8972	broad.mit.edu	37	7	141760157	141760157	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141760157G>A	uc003vwy.2	+	34	4160	c.4106G>A	c.(4105-4107)TGG>TAG	p.W1369*		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1369	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCTCTAGACTGGGACAGCCAA	0.483													10	49					0	0	0.000978159	0	0
MGAM	8972	broad.mit.edu	37	7	141763352	141763352	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141763352G>A	uc003vwy.2	+	36	4365	c.4311G>A	c.(4309-4311)AGG>AGA	p.R1437R		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1437	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CAGGCTGCAGGGACGCCTCTC	0.502													6	26					0	0	0.000157383	0	0
TRYX3	136541	broad.mit.edu	37	7	141952364	141952364	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:141952364G>A	uc003vxb.2	-	4	824	c.504C>T	c.(502-504)GCC>GCT	p.A168A	TRYX3_uc003vxc.3_Silent_p.A168A	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	168	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					AGGTTTTATAGGCATCGCGAC	0.428													30	146					0	0	0.00178596	0	0
TRY6	154754	broad.mit.edu	37	7	142481149	142481149	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:142481149G>A	uc011ksq.1	+	3	306	c.223G>A	c.(223-225)GAG>AAG	p.E75K	uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|uc003wan.1_Intron|TRY6_uc011ksr.1_RNA	NR_001296				SubName: Full=Protease, serine, 3; Flags: Fragment;												0						GAGACTGGGAGAGCACAATAT	0.532													9	0					0	0	0.000274275	0	0
EPHB6	2051	broad.mit.edu	37	7	142566359	142566359	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:142566359C>T	uc011kst.1	+	15	2935	c.2148C>T	c.(2146-2148)TTC>TTT	p.F716F	EPHB6_uc011ksu.1_Silent_p.F716F|EPHB6_uc003wbs.2_Silent_p.F424F|EPHB6_uc003wbt.2_Silent_p.F190F|EPHB6_uc003wbu.2_Silent_p.F424F|EPHB6_uc003wbv.2_Silent_p.F100F	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	716	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					AGATGACCTTCCTGGGCCGGG	0.697													7	25					0	0	0.00198382	0	0
KEL	3792	broad.mit.edu	37	7	142640645	142640645	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:142640645G>A	uc003wcb.2	-	15	1841	c.1631C>T	c.(1630-1632)TCG>TTG	p.S544L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	544	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					GTCAGATACCGAATAGTAAGC	0.557													89	27					0	0	0.000781405	0	0
OR6V1	346517	broad.mit.edu	37	7	142749553	142749553	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:142749553G>A	uc011ksv.1	+	1	116	c.116G>A	c.(115-117)GGA>GAA	p.G39E		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GCCTTCATGGGAAACACCATC	0.502													50	190					0	0	0.000781405	0	0
CLCN1	1180	broad.mit.edu	37	7	143044022	143044022	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143044022G>A	uc003wcr.1	+	20	2470	c.2383G>A	c.(2383-2385)GAT>AAT	p.D795N	CLCN1_uc011ktc.1_Missense_Mutation_p.D407N	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	795	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					AGATTTAGTGGATAACATGTC	0.398													85	35					0	0	0.000781405	0	0
CLCN1	1180	broad.mit.edu	37	7	143047536	143047536	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143047536C>T	uc003wcr.1	+	21	2562	c.2475C>T	c.(2473-2475)CCC>CCT	p.P825P	CLCN1_uc011ktc.1_Silent_p.P437P	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	825	CBS 2.|Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					ACCAGTCTCCCTTCCAGCTGG	0.562													35	8					0	0	0.000953801	0	0
FAM131B	9715	broad.mit.edu	37	7	143054043	143054043	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143054043G>A	uc003wct.2	-	6	2305	c.599C>T	c.(598-600)TCG>TTG	p.S200L	FAM131B_uc010loz.2_Missense_Mutation_p.S168L|FAM131B_uc003wcu.3_Missense_Mutation_p.S200L|FAM131B_uc010lpa.2_Missense_Mutation_p.S228L	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	200											0	Melanoma(164;0.205)					GGCATCTGACGACCCCAGACA	0.552													15	54					0	0	0.000422831	0	0
EPHA1	2041	broad.mit.edu	37	7	143095808	143095808	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143095808C>T	uc003wcz.2	-	6	1309	c.1222G>A	c.(1222-1224)GGC>AGC	p.G408S		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	408	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GGTTCAAGGCCATTGACATGC	0.632													35	61					0	0	0.000953801	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175679	143175679	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143175679C>T	uc003wdc.1	+	1	714	c.714C>T	c.(712-714)TCC>TCT	p.S238S	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	238	Helical; Name=6; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					CCCTCATCTCCTTCCTCATTC	0.507													46	77					0	0	0.000781405	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175862	143175862	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143175862G>A	uc003wdc.1	+	1	897	c.897G>A	c.(895-897)TTG>TTA	p.L299L	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	299	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					AGCTCCTGTTGTTGGCAAGGG	0.537													6	35					0	0	0.000157383	0	0
OR2F1	26211	broad.mit.edu	37	7	143657981	143657981	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143657981G>A	uc003wds.1	+	1	962	c.918G>A	c.(916-918)TGG>TGA	p.W306*		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	306	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					AACTATTATGGAAATTCTCTG	0.433													61	20					0	0	0.000781405	0	0
OR2A2	442361	broad.mit.edu	37	7	143806792	143806793	+	Missense_Mutation	DNP	GG	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143806792_143806793GG>TT	uc011ktz.1	+	1	117_118	c.117_118GG>TT	c.(115-120)CTGGGG>CTTTGG	p.G40W		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TCACCCTGCTGGGGAATGGGGT	0.515													9	162					0	0	6.4e-05	0	0
OR2A2	442361	broad.mit.edu	37	7	143807053	143807053	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:143807053C>T	uc011ktz.1	+	1	378	c.378C>T	c.(376-378)TGC>TGT	p.C126C		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TGGCCATCTGCCACCCTTTCC	0.473													34	120					0	0	0.0024448	0	0
NOBOX	135935	broad.mit.edu	37	7	144098256	144098256	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:144098256G>A	uc011kue.1	-	4	727	c.727C>T	c.(727-729)CAC>TAC	p.H243Y		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	243					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					TTGGCCAGGTGGCAGGGCCCC	0.602													21	7					0	0	0.00121646	0	0
ZNF398	57541	broad.mit.edu	37	7	148863939	148863939	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:148863939C>T	uc003wfl.2	+	4	853	c.578C>T	c.(577-579)TCT>TTT	p.S193F	ZNF398_uc011kul.1_Missense_Mutation_p.S22F|ZNF398_uc011kum.1_Missense_Mutation_p.S198F	NM_170686	NP_733787	Q8TD17	ZN398_HUMAN	zinc finger 398 isoform a	193	KRAB.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00143)			GATGTCTTATCTCAGATTCAA	0.428													15	3					0	0	0.000422831	0	0
GIMAP8	155038	broad.mit.edu	37	7	150164227	150164227	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:150164227C>T	uc003whj.2	+	2	771	c.441C>T	c.(439-441)TTC>TTT	p.F147F		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	147						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TGCAAGATTTCATTGAAAAAA	0.448													22	4					0	0	0.00229938	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325570	150325570	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr7:150325570C>T	uc003whn.2	-	3	540	c.116G>A	c.(115-117)AGG>AAG	p.R39K	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	39							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTCAGTCTCCTTGGGGTCTT	0.517													69	28					0	0	0.000781405	0	0
C8orf42	157695	broad.mit.edu	37	8	442449	442449	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:442449G>A	uc003wpd.2	-	3	1082	c.508C>T	c.(508-510)CGA>TGA	p.R170*	C8orf42_uc011kwg.1_Intron	NM_175075	NP_778250	Q86YL5	CH042_HUMAN	hypothetical protein LOC157695	170											0		Ovarian(12;0.0481)|Colorectal(14;0.0815)|Hepatocellular(245;0.0968)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;5.16e-14)|OV - Ovarian serous cystadenocarcinoma(5;7.35e-07)|BRCA - Breast invasive adenocarcinoma(11;4.17e-06)|COAD - Colon adenocarcinoma(149;0.0255)		CTCTGCCGTCGGATGCTCACC	0.642													14	7					0	0	0.000422831	0	0
CSMD1	64478	broad.mit.edu	37	8	3165994	3165994	+	Silent	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:3165994G>T	uc011kwk.1	-	24	4056	c.3666C>A	c.(3664-3666)GGC>GGA	p.G1222G	CSMD1_uc011kwj.1_Silent_p.G614G|CSMD1_uc003wqe.2_Silent_p.G378G	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1222	Extracellular (Potential).|Sushi 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGTTAGGGATGCCCGGATCCT	0.483													4	13					1.024e-07	3.49164e-07	0.000602214	1	0
SGK223	157285	broad.mit.edu	37	8	8176519	8176519	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:8176519G>A	uc003wsh.3	-	5	3366	c.3366C>T	c.(3364-3366)TTC>TTT	p.F1122F		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	1122	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GCAGAAGCAGGAAGCACACGC	0.672													78	61					0	0	0.000781405	0	0
SGK223	157285	broad.mit.edu	37	8	8234162	8234162	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:8234162G>A	uc003wsh.3	-	2	1757	c.1757C>T	c.(1756-1758)CCA>CTA	p.P586L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	586							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ACCTTGGGATGGAGGCTGGGG	0.677													17	10					0	0	0.00152264	0	0
MIR598	693183	broad.mit.edu	37	8	10892744	10892744	+	RNA	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:10892744G>A	hsa-mir-598|MI0003610	-			c.69G>A			XKR6_uc003wtk.1_Intron																	0						cgatgacaacgatgacgTAGC	0.299													37	22					0	0	0.00111076	0	0
C8orf79	57604	broad.mit.edu	37	8	12878918	12878918	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:12878918G>A	uc010lsq.2	+	5	1222	c.730G>A	c.(730-732)GGA>AGA	p.G244R	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Missense_Mutation_p.G157R|C8orf79_uc010lsr.2_Missense_Mutation_p.G118R	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	244							methyltransferase activity				0						CAGCACATTAGGAAAATCGTT	0.418													17	59					0	0	0.00074312	0	0
SGCZ	137868	broad.mit.edu	37	8	14181688	14181688	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:14181688G>A	uc003wwq.2	-	3	920	c.260C>T	c.(259-261)ACC>ATC	p.T87I	SGCZ_uc010lss.2_Intron	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	74	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		TCCCTTCTTGGTGACTCTCAG	0.368													22	20					0	0	0.000878237	0	0
ZDHHC2	51201	broad.mit.edu	37	8	17053131	17053131	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:17053131G>A	uc003wxe.2	+	4	768	c.371G>A	c.(370-372)GGA>GAA	p.G124E		NM_016353	NP_057437	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	124						integral to membrane	acyltransferase activity|zinc ion binding				0				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		ACCATGTCTGGAGGTAAATGT	0.413													44	27					0	0	0.000781405	0	0
SLC7A2	6542	broad.mit.edu	37	8	17417987	17417988	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:17417987_17417988CC>TT	uc011kyc.1	+	9	1618_1619	c.1449_1450CC>TT	c.(1447-1452)TCCCTT>TCTTTT	p.L484F	SLC7A2_uc011kyd.1_Missense_Mutation_p.L523F|SLC7A2_uc011kye.1_Missense_Mutation_p.L524F|SLC7A2_uc011kyf.1_Missense_Mutation_p.L484F	NM_001008539	NP_001008539	P52569	CTR2_HUMAN	solute carrier family 7, member 2 isoform 2	484	Cytoplasmic (Potential).				cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			ovary(2)|skin(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TCTGCCCCTCCCTTCTGCCAAC	0.535													18	67					0	0	6.4e-05	0	0
BMP1	649	broad.mit.edu	37	8	22033822	22033822	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:22033822C>T	uc003xbg.2	+	3	673	c.429C>T	c.(427-429)TTC>TTT	p.F143F	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Silent_p.F143F|BMP1_uc003xbb.2_Silent_p.F143F|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_5'UTR|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_5'UTR|BMP1_uc011kzc.1_5'UTR|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	143	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GGGGAAACTTCACTGGTGAGC	0.652													12	33					0	0	0.00185496	0	0
PIWIL2	55124	broad.mit.edu	37	8	22147395	22147395	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:22147395G>A	uc003xbn.2	+	9	1170	c.1022G>A	c.(1021-1023)AGA>AAA	p.R341K	PIWIL2_uc011kzf.1_Missense_Mutation_p.R341K|PIWIL2_uc010ltv.2_Missense_Mutation_p.R341K	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	341					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		CTTGTGGGGAGAAACTTTTAT	0.338													16	16					0	0	0.000422831	0	0
PEBP4	157310	broad.mit.edu	37	8	22675180	22675180	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:22675180G>A	uc003xcn.1	-	4	419	c.327C>T	c.(325-327)TTC>TTT	p.F109F		NM_144962	NP_659399	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	109						lysosome				ovary(1)|large_intestine(1)|breast(1)|skin(1)	4		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		AATGTCTCCAGAATCTCTGTC	0.483													57	42					0	0	0.000781405	0	0
TNFRSF10C	8794	broad.mit.edu	37	8	22969277	22969277	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:22969277C>T	uc003xcy.2	+	2	306	c.105C>T	c.(103-105)CCC>CCT	p.P35P	TNFRSF10C_uc011kzr.1_Intron	NM_003841	NP_003832	O14798	TR10C_HUMAN	tumor necrosis factor receptor superfamily,	35	TNFR-Cys 1.				apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		AGGAAGTTCCCCAGCAGACAG	0.527													8	15					0	0	0.000978159	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24251634	24251634	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:24251634G>A	uc003xdz.2	+	4	557	c.337G>A	c.(337-339)GAA>AAA	p.E113K	ADAMDEC1_uc010lub.2_Missense_Mutation_p.E34K|ADAMDEC1_uc011lab.1_Missense_Mutation_p.E34K	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	113					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CAGAGGAGAGGAAATTACCAC	0.453													8	14					0	0	0.000157383	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24256963	24256963	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:24256963C>T	uc003xdz.2	+	10	1207	c.987C>T	c.(985-987)TCC>TCT	p.S329S	ADAMDEC1_uc010lub.2_Silent_p.S250S|ADAMDEC1_uc011lab.1_Silent_p.S250S	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	329	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		CCTTGTGTTCCCCATCTTCGG	0.333													20	59					0	0	0.00229938	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24257714	24257714	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:24257714G>A	uc003xdz.2	+	11	1263	c.1043G>A	c.(1042-1044)GGA>GAA	p.G348E	ADAMDEC1_uc010lub.2_Missense_Mutation_p.G269E|ADAMDEC1_uc011lab.1_Missense_Mutation_p.G269E	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	348	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		GCTCTTGTAGGAGTGATGTCA	0.368													15	9					0	0	0.000308642	0	0
NEFL	4747	broad.mit.edu	37	8	24811210	24811210	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:24811210G>A	uc003xee.2	-	3	1371	c.1269C>T	c.(1267-1269)GCC>GCT	p.A423A		NM_006158	NP_006149	P07196	NFL_HUMAN	neurofilament, light polypeptide 68kDa	423	Tail.|Tail, subdomain A.				anterograde axon cargo transport|axon transport of mitochondrion|neurofilament bundle assembly|retrograde axon cargo transport|synaptic transmission	cytosol|neurofilament	identical protein binding|protein C-terminus binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.00965)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AACCGCCGTAGGCAGATCGGC	0.567													21	38					0	0	0.00229938	0	0
ADRA1A	148	broad.mit.edu	37	8	26623662	26623663	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:26623662_26623663CC>TT	uc003xfg.1	-	3	1709_1710	c.1273_1274GG>AA	c.(1273-1275)GGA>AAA	p.G425K	ADRA1A_uc003xfc.1_Intron|ADRA1A_uc010lul.1_Intron|ADRA1A_uc003xfd.1_Intron|ADRA1A_uc003xfe.1_Intron|ADRA1A_uc010lum.1_Intron|ADRA1A_uc003xff.1_Intron	NM_033304	NP_150647	P35348	ADA1A_HUMAN	alpha-1A-adrenergic receptor isoform 4	Error:Variant_position_missing_in_P35348_after_alignment					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	ACAATCCATTCCCCTCTGTCCA	0.376													8	46					0	0	6.4e-05	0	0
TEX15	56154	broad.mit.edu	37	8	30705720	30705720	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:30705720G>A	uc003xil.2	-	1	814	c.814C>T	c.(814-816)CCA>TCA	p.P272S		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	272										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TTATCTATTGGACTGATTTTT	0.313													17	63					0	0	0.00121646	0	0
DUSP26	78986	broad.mit.edu	37	8	33451117	33451117	+	Missense_Mutation	SNP	A	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:33451117A>T	uc003xjp.2	-	3	703	c.370T>A	c.(370-372)TTT>ATT	p.F124I	DUSP26_uc003xjq.2_Missense_Mutation_p.F124I	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	124	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CTCATGTCAAAGGCTGGCGAG	0.642													11	65					0	0	0.000673444	0	0
FGFR1	2260	broad.mit.edu	37	8	38275752	38275752	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:38275752C>T	uc003xlp.2	-	11	2366	c.1424G>A	c.(1423-1425)CGG>CAG	p.R475Q	FGFR1_uc010lwf.2_RNA|FGFR1_uc011lbo.1_Missense_Mutation_p.R473Q|FGFR1_uc011lbp.1_Missense_Mutation_p.R386Q|FGFR1_uc011lbq.1_Missense_Mutation_p.R384Q|FGFR1_uc010lwk.2_Missense_Mutation_p.R465Q	NM_023110	NP_075598	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1 isoform 1	475	Cytoplasmic (Potential).				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity			lung(5)|central_nervous_system(5)|stomach(2)|breast(2)|ovary(1)	15	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	TTACCTGTCCCGAGGCAGCTC	0.532		1	T	BCR|FOP|ZNF198|CEP1	MPD|NHL		Pfeiffer syndrome|Kallman syndrome						85	81					0	0	0.000781405	0	0
ADAM32	203102	broad.mit.edu	37	8	39080710	39080710	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:39080710G>A	uc003xmt.3	+	14	1723	c.1478G>A	c.(1477-1479)GGA>GAA	p.G493E	ADAM32_uc011lch.1_Missense_Mutation_p.G394E|ADAM32_uc003xmu.3_Missense_Mutation_p.G387E|ADAM32_uc003xmv.2_Missense_Mutation_p.E15K	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	493	Extracellular (Potential).|Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TGTTATGACGGAGACTGCCAT	0.343													10	11					0	0	0.000978159	0	0
ADAM18	8749	broad.mit.edu	37	8	39564414	39564414	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:39564414C>T	uc003xni.2	+	18	2008	c.2008C>T	c.(2008-2010)CAG>TAG	p.Q670*	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Nonsense_Mutation_p.Q646*	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	670	Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TGGAAATTTTCAGAAATCTGG	0.328													38	51					0	0	0.000953801	0	0
ADAM2	2515	broad.mit.edu	37	8	39604031	39604031	+	Nonsense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:39604031G>A	uc003xnj.2	-	19	2209	c.2134C>T	c.(2134-2136)CAA>TAA	p.Q712*	ADAM2_uc003xnk.2_Nonsense_Mutation_p.Q693*|ADAM2_uc011lck.1_Nonsense_Mutation_p.Q649*|ADAM2_uc003xnl.2_Nonsense_Mutation_p.Q556*	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	712	Cytoplasmic (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		TTTTTCCTTTGGAAATTAACT	0.284													56	82					0	0	0.000781405	0	0
ADAM2	2515	broad.mit.edu	37	8	39678582	39678582	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:39678582G>A	uc003xnj.2	-	6	527	c.452C>T	c.(451-453)TCC>TTC	p.S151F	ADAM2_uc003xnk.2_Missense_Mutation_p.S151F|ADAM2_uc011lck.1_Missense_Mutation_p.S151F|ADAM2_uc003xnl.2_Missense_Mutation_p.S151F	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	151					cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ATTATATAAGGAAACATCTGC	0.323													33	61					0	0	0.00058488	0	0
SFRP1	6422	broad.mit.edu	37	8	41122947	41122947	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:41122947C>T	uc003xnt.2	-	3	986	c.684G>A	c.(682-684)AAG>AAA	p.K228K		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1 precursor	228	NTR.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			GCTTCTTCTTCTTGGGGACAA	0.473													25	50					0	0	0.000586117	0	0
AGPAT6	137964	broad.mit.edu	37	8	41470463	41470463	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:41470463C>T	uc003xnz.2	+	8	1834	c.895C>T	c.(895-897)CAC>TAC	p.H299Y		NM_178819	NP_848934	Q86UL3	GPAT4_HUMAN	lysophosphatidic acid acyltransferase zeta	299					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity				0	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			GAAGGATCGCCACCTGGTGGC	0.542											OREG0018739	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	13					0	0	0.000274275	0	0
AP3M2	10947	broad.mit.edu	37	8	42024823	42024823	+	Silent	SNP	C	T	T	rs146759837		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:42024823C>T	uc003xop.2	+	8	1236	c.945C>T	c.(943-945)CCC>CCT	p.P315P	AP3M2_uc003xoo.2_Silent_p.P315P|AP3M2_uc010lxe.2_Intron	NM_001134296	NP_001127768	P53677	AP3M2_HUMAN	adaptor-related protein complex 3, mu 2 subunit	315	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus					0	all_cancers(6;8.14e-25)|all_epithelial(6;2.41e-27)|all_lung(13;5.09e-13)|Lung NSC(13;8.38e-12)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|Colorectal(10;0.00165)|OV - Ovarian serous cystadenocarcinoma(14;0.00346)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)			GCCAGATGCCCAAGGGGGTCC	0.537													18	41					0	0	0.00074312	0	0
PRKDC	5591	broad.mit.edu	37	8	48839794	48839794	+	Silent	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:48839794G>T	uc003xqi.2	-	21	2436	c.2379C>A	c.(2377-2379)CTC>CTA	p.L793L	PRKDC_uc003xqj.2_Silent_p.L793L|PRKDC_uc011ldh.1_Silent_p.L793L	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	793					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CCAGGCAGGGGAGAATGTCTT	0.388								NHEJ					14	30					3.35478e-16	1.15072e-15	0.000308642	1	0
ST18	9705	broad.mit.edu	37	8	53044633	53044633	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:53044633G>A	uc003xqz.2	-	17	2707	c.2551C>T	c.(2551-2553)CCT>TCT	p.P851S	ST18_uc011ldq.1_Missense_Mutation_p.P498S|ST18_uc011ldr.1_Missense_Mutation_p.P816S|ST18_uc011lds.1_Missense_Mutation_p.P756S|ST18_uc003xra.2_Missense_Mutation_p.P851S	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	851						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CCATTGAGAGGATTCTCCTTC	0.498													25	38					0	0	0.000720815	0	0
ST18	9705	broad.mit.edu	37	8	53079445	53079445	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:53079445C>G	uc003xqz.2	-	6	1327	c.1171G>C	c.(1171-1173)GGG>CGG	p.G391R	ST18_uc011ldq.1_Missense_Mutation_p.G38R|ST18_uc011ldr.1_Missense_Mutation_p.G356R|ST18_uc011lds.1_Missense_Mutation_p.G296R|ST18_uc003xra.2_Missense_Mutation_p.G391R|ST18_uc003xrb.2_Missense_Mutation_p.G391R	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	391	C2HC-type 1.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGGGGGCACCCCGAAAGGCTG	0.562													43	49					0	0	0.0025221	0	0
RP1	6101	broad.mit.edu	37	8	55540655	55540655	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:55540655G>A	uc003xsd.1	+	4	4361	c.4213G>A	c.(4213-4215)GAA>AAA	p.E1405K	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1405					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGCCTAAGTGAAAAAGAAGC	0.318													27	61					0	0	0.000720815	0	0
CA8	767	broad.mit.edu	37	8	61178606	61178606	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:61178606G>A	uc003xtz.1	-	3	543	c.295C>T	c.(295-297)CTT>TTT	p.L99F	CA8_uc003xua.1_Missense_Mutation_p.L99F|CA8_uc003xub.2_Missense_Mutation_p.L99F	NM_004056	NP_004047	P35219	CAH8_HUMAN	carbonic anhydrase VIII	99					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0		all_cancers(86;0.172)|all_epithelial(80;0.0383)|all_lung(136;0.0413)|Lung NSC(129;0.0474)				CCTCCCGAAAGAACTGAAAAA	0.393													14	23					0	0	0.000422831	0	0
CHD7	55636	broad.mit.edu	37	8	61655051	61655051	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:61655051C>T	uc003xue.2	+	2	1537	c.1060C>T	c.(1060-1062)CCA>TCA	p.P354S		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	354					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TGTAGGATTCCCATCAAACAG	0.438													39	27					0	0	0.00128727	0	0
ASPH	444	broad.mit.edu	37	8	62489366	62489367	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:62489366_62489367GG>AA	uc003xuj.2	-	16	1382_1383	c.1113_1114CC>TT	c.(1111-1116)TACCCT>TATTCT	p.P372S	ASPH_uc011leg.1_Missense_Mutation_p.P343S|ASPH_uc003xuo.2_Missense_Mutation_p.P353S|uc003xuk.2_5'Flank	NM_004318	NP_004309	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase isoform a	372	TPR 1.|Lumenal (Potential).				muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			ovary(3)	3	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	GGACTCTGAGGGTATTTGCGTA	0.332													45	62					0	0	6.4e-05	0	0
C8orf34	116328	broad.mit.edu	37	8	69552622	69552622	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:69552622G>A	uc010lyz.2	+	8	908	c.859G>A	c.(859-861)GAT>AAT	p.D287N	C8orf34_uc003xyb.2_Missense_Mutation_p.D262N	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	287					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GGATCTTAATGATTTAAGAAT	0.398													22	25					0	0	0.00047179	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70585174	70585174	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:70585174G>A	uc003xyl.2	-	10	3184	c.2477C>T	c.(2476-2478)CCA>CTA	p.P826L	SLCO5A1_uc010lzb.2_Missense_Mutation_p.P771L|SLCO5A1_uc011lfa.1_RNA|SLCO5A1_uc003xyk.2_3'UTR	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	826						integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TATTGCTTCTGGGAAGGGCCC	0.562													45	54					0	0	0.000781405	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70667783	70667783	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:70667783T>A	uc003xyl.2	-	4	1841	c.1134A>T	c.(1132-1134)AAA>AAT	p.K378N	SLCO5A1_uc010lzb.2_Missense_Mutation_p.K378N|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.K378N|SLCO5A1_uc010lzc.2_Missense_Mutation_p.K378N	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	378	Cytoplasmic (Potential).|Poly-Lys.					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TCTTTTTCTTTTTCTTGTGTC	0.368													26	42					0	0	0.000586117	0	0
KCNB2	9312	broad.mit.edu	37	8	73848625	73848625	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:73848625G>A	uc003xzb.2	+	3	1623	c.1035G>A	c.(1033-1035)GGG>GGA	p.G345G		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	345	Helical; Name=Segment S5; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TGGCCATGGGGATAATGATAT	0.473													39	71					0	0	0.00285205	0	0
C8orf84	157869	broad.mit.edu	37	8	73982117	73982117	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:73982117C>T	uc003xzf.2	-	4	805	c.600G>A	c.(598-600)ACG>ACA	p.T200T		NM_153225	NP_694957	Q8IVN8	RPESP_HUMAN	RPE-spondin precursor	200					immune response	extracellular region	polysaccharide binding|scavenger receptor activity				0						CCACACACACCGTGTATCCCT	0.488													34	22					0	0	0.000692331	0	0
PI15	51050	broad.mit.edu	37	8	75756215	75756215	+	Splice_Site	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:75756215G>A	uc003yal.2	+	3	453	c.274_splice	c.e3-1	p.V92_splice	uc003yak.1_Intron|PI15_uc003yam.2_Splice_Site_p.V92_splice	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein							extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TTCCCCTACAGGTTTGGGATG	0.393													62	56					0	0	0.000781405	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764907	77764907	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:77764907G>A	uc003yav.2	+	10	6002	c.5615G>A	c.(5614-5616)GGT>GAT	p.G1872D	ZFHX4_uc003yau.1_Missense_Mutation_p.G1917D|ZFHX4_uc003yaw.1_Missense_Mutation_p.G1872D	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1872						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAAAACTTTGGTTTTGAACTG	0.448										HNSCC(33;0.089)			15	16					0	0	0.00244969	0	0
PAG1	55824	broad.mit.edu	37	8	81888983	81888983	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:81888983G>A	uc003ybz.2	-	9	1806	c.1095C>T	c.(1093-1095)TTC>TTT	p.F365F		NM_018440	NP_060910	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid	365	Cytoplasmic (Potential).				epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity				0	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			GAGTTTTTTCGAAGTCTTTAA	0.507													21	46					0	0	0.00188189	0	0
CA13	377677	broad.mit.edu	37	8	86180738	86180738	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:86180738C>T	uc003ydg.2	+	6	893	c.551C>T	c.(550-552)TCT>TTT	p.S184F	CA13_uc003ydf.1_RNA	NM_198584	NP_940986	Q8N1Q1	CAH13_HUMAN	carbonic anhydrase XIII	184					one-carbon metabolic process		carbonate dehydratase activity|zinc ion binding				0						GACCTATTGTCTCTGCTTCCA	0.398													56	57					0	0	0.000781405	0	0
CA1	759	broad.mit.edu	37	8	86241982	86241982	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:86241982G>C	uc003ydh.2	-	8	805	c.605C>G	c.(604-606)CCT>CGT	p.P202R	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.P202R|CA1_uc003ydi.2_Missense_Mutation_p.P202R	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	202					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	ATAAAGAGGAGGATGAGTCAG	0.483													4	8					0	0	0.000602214	0	0
CNGB3	54714	broad.mit.edu	37	8	87683209	87683209	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:87683209C>T	uc003ydx.2	-	4	502	c.456G>A	c.(454-456)GAG>GAA	p.E152E	CNGB3_uc010maj.2_Silent_p.E14E	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	152	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						AGAGATCTCCCTCTACCAACT	0.498													125	127					0	0	0.000781405	0	0
CNBD1	168975	broad.mit.edu	37	8	87917317	87917317	+	Missense_Mutation	SNP	T	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:87917317T>A	uc003ydy.2	+	3	215	c.167T>A	c.(166-168)ATG>AAG	p.M56K		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	56										ovary(3)	3						AGCCGGAGTATGAGCAATATC	0.333													8	22					0	0	0.000157383	0	0
RUNX1T1	862	broad.mit.edu	37	8	93029550	93029550	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:93029550C>T	uc003yfd.2	-	2	214	c.130G>A	c.(130-132)GAT>AAT	p.D44N	RUNX1T1_uc003yfc.1_Missense_Mutation_p.D17N|RUNX1T1_uc003yfe.1_Missense_Mutation_p.D7N|RUNX1T1_uc010mao.2_Missense_Mutation_p.D17N|RUNX1T1_uc011lgi.1_Missense_Mutation_p.D55N|RUNX1T1_uc003yfh.1_Missense_Mutation_p.D7N|RUNX1T1_uc003yfb.1_Missense_Mutation_p.D7N|RUNX1T1_uc003yff.1_Missense_Mutation_p.D7N|RUNX1T1_uc003yfg.1_Missense_Mutation_p.D7N	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	44					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			GTCTTCACATCCACAGGTGAG	0.473													31	30					0	0	0.0024448	0	0
ESRP1	54845	broad.mit.edu	37	8	95653570	95653570	+	Missense_Mutation	SNP	G	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:95653570G>T	uc003ygq.3	+	1	207	c.24G>T	c.(22-24)TTG>TTT	p.L8F	ESRP1_uc003ygr.3_Missense_Mutation_p.L8F|ESRP1_uc003ygs.3_Missense_Mutation_p.L8F|ESRP1_uc003ygt.3_Missense_Mutation_p.L8F|ESRP1_uc003ygu.3_Missense_Mutation_p.L8F	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	8					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						CGGATTACTTGGTGGTGCTTT	0.587													10	422					0.000151284	0.000512386	0.00185496	1	0
DPY19L4	286148	broad.mit.edu	37	8	95778881	95778881	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:95778881C>T	uc003ygx.2	+	11	1267	c.1143C>T	c.(1141-1143)TTC>TTT	p.F381F		NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	381						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					TGCTGAAATTCCTTGAAGTAA	0.303													187	213					0	0	0.000781405	0	0
PABPC1	26986	broad.mit.edu	37	8	101733795	101733795	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:101733795G>A	uc003yjs.1	-	1	521	c.17C>T	c.(16-18)CCC>CTC	p.P6L	PABPC1_uc011lhc.1_Missense_Mutation_p.P6L|PABPC1_uc011lhd.1_Intron|PABPC1_uc003yjt.1_Missense_Mutation_p.P6L|PABPC1_uc003yju.2_RNA	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	6					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			GGGGTAGCTGGGGGCACTGGG	0.711													19	11					0	0	0.00188189	0	0
NCALD	83988	broad.mit.edu	37	8	102701627	102701627	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:102701627G>A	uc003yke.2	-	4	861	c.492C>T	c.(490-492)CTC>CTT	p.L164L	NCALD_uc003ykf.2_Silent_p.L164L|NCALD_uc003ykg.2_Silent_p.L164L|NCALD_uc003ykh.2_Silent_p.L164L|NCALD_uc003yki.2_Silent_p.L164L|NCALD_uc003ykj.2_Silent_p.L164L|NCALD_uc003ykk.2_Silent_p.L164L|NCALD_uc003ykl.2_Silent_p.L164L	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	164	EF-hand 4.|3 (Potential).				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CTTCCAGGGAGAGTTTTCCTA	0.607													9	10					0	0	0.000274275	0	0
RIMS2	9699	broad.mit.edu	37	8	104897612	104897612	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:104897612C>T	uc003yls.2	+	2	360	c.119C>T	c.(118-120)TCG>TTG	p.S40L	RIMS2_uc003ylp.2_Missense_Mutation_p.S262L|RIMS2_uc003ylw.2_Missense_Mutation_p.S70L|RIMS2_uc003ylq.2_Missense_Mutation_p.S70L|RIMS2_uc003ylr.2_Missense_Mutation_p.S70L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	293					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TATGCTACTTCGGATACCGCA	0.408										HNSCC(12;0.0054)			21	32					0	0	0.00152264	0	0
RIMS2	9699	broad.mit.edu	37	8	104922429	104922429	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:104922429G>A	uc003yls.2	+	3	1267	c.1026G>A	c.(1024-1026)TTG>TTA	p.L342L	RIMS2_uc003ylp.2_Silent_p.L564L|RIMS2_uc003ylw.2_Silent_p.L372L|RIMS2_uc003ylq.2_Silent_p.L372L|RIMS2_uc003ylr.2_Intron|RIMS2_uc003ylt.2_5'Flank	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CAATGTCTTTGGTGAGACATG	0.368										HNSCC(12;0.0054)			53	123					0	0	0.000781405	0	0
RIMS2	9699	broad.mit.edu	37	8	105257214	105257214	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:105257214G>A	uc003yls.2	+	24	3700	c.3459G>A	c.(3457-3459)AGG>AGA	p.R1153R	RIMS2_uc003ylp.2_Silent_p.R1135R|RIMS2_uc003ylw.2_Silent_p.R1142R|RIMS2_uc003ylq.2_Silent_p.R949R|RIMS2_uc003ylr.2_Silent_p.R974R	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1197					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGAAATGAGGAACTGGATGA	0.473										HNSCC(12;0.0054)			113	86					0	0	0.000781405	0	0
TMEM74	157753	broad.mit.edu	37	8	109796737	109796737	+	Silent	SNP	G	A	A	rs139123399		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:109796737G>A	uc003ymy.1	-	2	696	c.591C>T	c.(589-591)ATC>ATT	p.I197I	TMEM74_uc003ymx.2_Intron	NM_153015	NP_694560	Q96NL1	TMM74_HUMAN	transmembrane protein 74	197	Helical; (Potential).				autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			CCCGTGGGACGATGTAAGAGA	0.572													30	71					0	0	0.00178596	0	0
TRHR	7201	broad.mit.edu	37	8	110100064	110100064	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:110100064G>A	uc003ymz.3	+	1	339	c.323G>A	c.(322-324)GGA>GAA	p.G108E		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	108	Helical; Name=3; (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CAGTATTTGGGAATTAATGCA	0.463													85	48					0	0	0.000781405	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110464991	110464991	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:110464991C>T	uc003yne.2	+	43	6656	c.6552C>T	c.(6550-6552)TTC>TTT	p.F2184F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2184	Extracellular (Potential).|G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCTCCAATTTCTCATGGGGGG	0.383										HNSCC(38;0.096)			8	10					0	0	0.000274275	0	0
CSMD3	114788	broad.mit.edu	37	8	113529379	113529379	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:113529379C>T	uc003ynu.2	-	28	4799	c.4640G>A	c.(4639-4641)GGG>GAG	p.G1547E	CSMD3_uc003yns.2_Missense_Mutation_p.G819E|CSMD3_uc003ynt.2_Missense_Mutation_p.G1507E|CSMD3_uc011lhx.1_Missense_Mutation_p.G1443E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1547	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACAGTGTCCCCAGGTTCTCT	0.478										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			30	45					0	0	0.00209593	0	0
CSMD3	114788	broad.mit.edu	37	8	114326957	114326957	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:114326957G>A	uc003ynu.2	-	2	403	c.244C>T	c.(244-246)CCA>TCA	p.P82S	CSMD3_uc003ynt.2_Missense_Mutation_p.P42S|CSMD3_uc011lhx.1_Missense_Mutation_p.P82S|CSMD3_uc010mcx.1_Missense_Mutation_p.P82S|CSMD3_uc003ynx.3_Missense_Mutation_p.P82S	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	82	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TATCCATATGGAAAACCAGGG	0.328										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			82	178					0	0	0.000781405	0	0
TRPS1	7227	broad.mit.edu	37	8	116599542	116599543	+	Nonsense_Mutation	DNP	CG	AT	AT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:116599542_116599543CG>AT	uc003ynz.2	-	4	2805_2806	c.2346_2347CG>AT	c.(2344-2349)ACCGAG>ACATAG	p.E783*	TRPS1_uc011lhy.1_Nonsense_Mutation_p.E787*|TRPS1_uc003yny.2_Nonsense_Mutation_p.E796*|TRPS1_uc010mcy.2_Nonsense_Mutation_p.E783*	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	783	Mediates interaction with GLI3.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CTGGAACTCTCGGTCCAAACTT	0.545									Langer-Giedion_syndrome				8	538					0	0	6.4e-05	0	0
TRPS1	7227	broad.mit.edu	37	8	116631597	116631597	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:116631597C>T	uc003ynz.2	-	2	1148	c.689G>A	c.(688-690)GGT>GAT	p.G230D	TRPS1_uc011lhy.1_Missense_Mutation_p.G234D|TRPS1_uc003yny.2_Missense_Mutation_p.G243D|TRPS1_uc010mcy.2_Missense_Mutation_p.G230D	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	230	C2H2-type 1; atypical.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GCCGTAGTAACCATATCCACA	0.468									Langer-Giedion_syndrome				55	138					0	0	0.000781405	0	0
SLC30A8	169026	broad.mit.edu	37	8	118165314	118165314	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:118165314G>A	uc003yoh.2	+	3	633	c.403G>A	c.(403-405)GGA>AGA	p.G135R	SLC30A8_uc010mcz.2_Missense_Mutation_p.G86R|SLC30A8_uc011lia.1_Missense_Mutation_p.G86R|SLC30A8_uc003yog.2_Missense_Mutation_p.G86R	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	135	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			GCTGACATTTGGATGGCACCG	0.517													109	251					0	0	0.000781405	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119945254	119945254	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:119945254C>T	uc003yon.3	-	2	639	c.316G>A	c.(316-318)GAA>AAA	p.E106K	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	106					apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			TCCTTGCATTCGCACACGCGG	0.557													28	56					0	0	0.000878237	0	0
MTSS1	9788	broad.mit.edu	37	8	125565768	125565768	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:125565768C>T	uc003yrk.2	-	14	2267	c.1733G>A	c.(1732-1734)GGA>GAA	p.G578E	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_Missense_Mutation_p.G227E|MTSS1_uc011lin.1_Missense_Mutation_p.G352E|MTSS1_uc011lio.1_Missense_Mutation_p.G468E|MTSS1_uc003yri.2_Missense_Mutation_p.G296E|MTSS1_uc003yrj.2_Missense_Mutation_p.G553E|MTSS1_uc003yrl.2_Missense_Mutation_p.G582E	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	578					actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CATAGCAGGTCCCAGGGTGGT	0.607													24	47					0	0	0.00278032	0	0
ZNF572	137209	broad.mit.edu	37	8	125988914	125988914	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:125988914C>T	uc003yrr.2	+	3	559	c.404C>T	c.(403-405)TCC>TTC	p.S135F		NM_152412	NP_689625	Q7Z3I7	ZN572_HUMAN	zinc finger protein 572	135	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			TATAAATGTTCCGAATGTTGG	0.438										HNSCC(60;0.17)			64	53					0	0	0.000781405	0	0
MIR1205	100302161	broad.mit.edu	37	8	128972912	128972912	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:128972912C>T	hsa-mir-1205|MI0006338	+			c.34C>T			PVT1_uc010mdq.2_Intron|PVT1_uc003ysl.2_Intron																	0						TGAGGTACTTCCTTCCTGTCA	0.368													20	62					0	0	0.00152264	0	0
TG	7038	broad.mit.edu	37	8	134042158	134042158	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:134042158C>T	uc003ytw.2	+	41	7170	c.7129C>T	c.(7129-7131)CCT>TCT	p.P2377S	TG_uc010mdw.2_Missense_Mutation_p.P1136S|TG_uc011ljb.1_Missense_Mutation_p.P746S|TG_uc011ljc.1_Missense_Mutation_p.P510S	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2377					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TGGCGGGGACCCTCGGCGCGT	0.662													17	44					0	0	0.00074312	0	0
WISP1	8840	broad.mit.edu	37	8	134233063	134233063	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:134233063C>T	uc003yub.2	+	3	665	c.589C>T	c.(589-591)CCC>TCC	p.P197S	WISP1_uc003yuc.2_Intron|WISP1_uc010meb.2_Intron|WISP1_uc010mec.2_Intron|WISP1_uc010med.2_Intron|WISP1_uc003yud.2_Intron	NM_003882	NP_003873	O95388	WISP1_HUMAN	WNT1 inducible signaling pathway protein 1	197					cell adhesion|cell-cell signaling|regulation of cell growth|Wnt receptor signaling pathway	extracellular region|soluble fraction	insulin-like growth factor binding			central_nervous_system(1)|kidney(1)	2	all_epithelial(106;5.39e-23)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			CAAGACCGCACCCCGTGACAC	0.657													12	33					0	0	0.000978159	0	0
NDRG1	10397	broad.mit.edu	37	8	134296509	134296509	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:134296509A>G	uc003yuh.2	-	2	632	c.46T>C	c.(46-48)TTG>CTG	p.L16L	NDRG1_uc003yug.2_Silent_p.L16L|NDRG1_uc010mee.2_5'UTR|NDRG1_uc010mef.2_Intron|NDRG1_uc011ljh.1_5'UTR|NDRG1_uc011lji.1_Silent_p.L16L	NM_001135242	NP_001128714	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	16					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding			ovary(4)	4	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			TTCTCCACCAAAGGCTTCACC	0.403													15	42					0	0	0.00074312	0	0
FAM135B	51059	broad.mit.edu	37	8	139323149	139323149	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:139323149C>T	uc003yuy.2	-	3	263	c.92G>A	c.(91-93)CGA>CAA	p.R31Q	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	31										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CAAGGTCACTCGGATCTGGTA	0.493										HNSCC(54;0.14)			31	60					0	0	0.00178596	0	0
FAM135B	51059	broad.mit.edu	37	8	139380153	139380153	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:139380153C>T	uc003yuy.2	-	2	245	c.74G>A	c.(73-75)AGA>AAA	p.R25K	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	25										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TACTTACCCTCTCTGAAAGAG	0.323										HNSCC(54;0.14)			25	74					0	0	0.000586117	0	0
COL22A1	169044	broad.mit.edu	37	8	139603680	139603680	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:139603680G>A	uc003yvd.2	-	64	5127	c.4680C>T	c.(4678-4680)CCC>CCT	p.P1560P	COL22A1_uc011ljo.1_Silent_p.P840P	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1560	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGATTCCAGGGGGTCCCATCT	0.602										HNSCC(7;0.00092)			10	20					0	0	0.000978159	0	0
COL22A1	169044	broad.mit.edu	37	8	139626126	139626126	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:139626126C>T	uc003yvd.2	-	56	4409	c.3962G>A	c.(3961-3963)GGA>GAA	p.G1321E	COL22A1_uc011ljo.1_Missense_Mutation_p.G601E	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1321	Pro-rich.|Gly-rich.|Collagen-like 13.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCCCCTTGGTCCTTGGGGACC	0.448										HNSCC(7;0.00092)			54	185					0	0	0.000781405	0	0
COL22A1	169044	broad.mit.edu	37	8	139729076	139729076	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:139729076C>T	uc003yvd.2	-	28	2839	c.2392G>A	c.(2392-2394)GGA>AGA	p.G798R	COL22A1_uc011ljo.1_Missense_Mutation_p.G98R	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	798	Pro-rich.|Gly-rich.|Collagen-like 6.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			ACCTTCTCTCCAGGTCGGCCT	0.358										HNSCC(7;0.00092)			57	35					0	0	0.000781405	0	0
COL22A1	169044	broad.mit.edu	37	8	139833474	139833474	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:139833474G>A	uc003yvd.2	-	7	1597	c.1150C>T	c.(1150-1152)CTG>TTG	p.L384L		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	384	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GTCTGCACCAGCGCACAGTCA	0.572										HNSCC(7;0.00092)			26	64					0	0	0.000878237	0	0
FLJ43860	389690	broad.mit.edu	37	8	142486025	142486025	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:142486025C>T	uc003ywi.2	-	13	1749	c.1668G>A	c.(1666-1668)CAG>CAA	p.Q556Q	FLJ43860_uc011ljs.1_Intron|FLJ43860_uc010meu.1_Intron	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	556							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CACAGCAAACCTGTAGGTGCT	0.498													6	18					0	0	0.00116845	0	0
FLJ43860	389690	broad.mit.edu	37	8	142505528	142505528	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:142505528C>T	uc003ywi.2	-	3	399	c.318G>A	c.(316-318)AAG>AAA	p.K106K	FLJ43860_uc011ljs.1_5'Flank|FLJ43860_uc010meu.1_5'Flank	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	106							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGATGATGTACTTCAAGTGGA	0.522													49	87					0	0	0.000781405	0	0
SLURP1	57152	broad.mit.edu	37	8	143822687	143822687	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:143822687G>A	uc003ywy.2	-	3	212	c.186C>T	c.(184-186)CCC>CCT	p.P62P		NM_020427	NP_065160	P55000	SLUR1_HUMAN	ARS component B precursor	62	UPAR/Ly6.				cell activation|cell adhesion	extracellular space	cytokine activity				0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TCTGGTTGAAGGGGTACTCTG	0.682													8	16					0	0	0.000157383	0	0
CYP11B1	1584	broad.mit.edu	37	8	143958196	143958196	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:143958196G>A	uc003yxi.2	-	4	708	c.701C>T	c.(700-702)ACC>ATC	p.T234I	CYP11B1_uc010mex.2_5'Flank|CYP11B1_uc003yxh.2_5'Flank|CYP11B1_uc003yxj.2_Missense_Mutation_p.T234I|CYP11B1_uc010mey.2_Missense_Mutation_p.T305I	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	234					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GAGCTGGACGGTGGATTTGAA	0.587									Familial_Hyperaldosteronism_type_I				21	36					0	0	0.00047179	0	0
TIGD5	84948	broad.mit.edu	37	8	144681846	144681846	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:144681846C>T	uc003yyx.1	+	1	1626	c.1626C>T	c.(1624-1626)GCC>GCT	p.A542A	EEF1D_uc011lki.1_5'Flank|EEF1D_uc011lkj.1_5'Flank|EEF1D_uc003yyr.2_5'Flank|EEF1D_uc003yyt.2_5'Flank|EEF1D_uc011lkk.1_5'Flank|EEF1D_uc003yys.2_5'Flank|EEF1D_uc003yyv.2_5'Flank|EEF1D_uc003yyu.2_5'Flank|EEF1D_uc011lkl.1_5'Flank	NM_032862	NP_116251	Q53EQ6	TIGD5_HUMAN	tigger transposable element derived 5	591					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CCGGGGAGGCCGTGCGGGGGC	0.682													18	12					0	0	0.00152264	0	0
PYCRL	65263	broad.mit.edu	37	8	144687954	144687954	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:144687954G>A	uc003yyy.2	-	6	787	c.777C>T	c.(775-777)GCC>GCT	p.A259A	PYCRL_uc011lkm.1_Silent_p.A239A|PYCRL_uc011lkn.1_RNA	NM_023078	NP_075566	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	247					proline biosynthetic process		pyrroline-5-carboxylate reductase activity				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CCTGCTCCAGGGCGTGGAGTC	0.682													29	71					0	0	0.0024448	0	0
EPPK1	83481	broad.mit.edu	37	8	144942631	144942631	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:144942631C>T	uc003zaa.1	-	1	4804	c.4791G>A	c.(4789-4791)CGG>CGA	p.R1597R		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1597	Plectin 26.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGTGCCAGGCCGCAGGATGT	0.642													25	19					0	0	0.000586117	0	0
OPLAH	26873	broad.mit.edu	37	8	145109474	145109474	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:145109474G>A	uc003zar.3	-	19	2758	c.2676C>T	c.(2674-2676)TTC>TTT	p.F892F	OPLAH_uc003zas.1_Missense_Mutation_p.P167S	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	892							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CCTCCTCCTGGAAGACGCCCC	0.647													14	18					0	0	0.00244969	0	0
OPLAH	26873	broad.mit.edu	37	8	145111949	145111949	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:145111949G>A	uc003zar.3	-	12	1690	c.1608C>T	c.(1606-1608)TCC>TCT	p.S536S	OPLAH_uc003zas.1_5'Flank	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	536							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	CGTAGAGCAGGGAGCAGGGTT	0.672													4	13					0	0	0.000602214	0	0
VPS28	51160	broad.mit.edu	37	8	145649612	145649612	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:145649612G>A	uc003zcr.1	-	7	495	c.442C>T	c.(442-444)CGC>TGC	p.R148C	VPS28_uc003zcs.1_Missense_Mutation_p.R148C|VPS28_uc003zct.1_Missense_Mutation_p.R148C	NM_016208	NP_057292	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 isoform 1	148	VPS28 C-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TCCATGGCGCGGATCTCCAGG	0.677													19	62					0	0	0.00188189	0	0
KIFC2	90990	broad.mit.edu	37	8	145692696	145692697	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:145692696_145692697CC>TT	uc003zcz.2	+	4	506_507	c.441_442CC>TT	c.(439-444)GCCCCT>GCTTCT	p.P148S	CYHR1_uc003zcv.2_5'Flank|CYHR1_uc003zcw.2_5'Flank|CYHR1_uc003zcx.2_5'Flank|CYHR1_uc003zcy.2_5'Flank	NM_145754	NP_665697	Q96AC6	KIFC2_HUMAN	kinesin family member C2	148					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTCAGCCAGCCCCTCGGGTCCG	0.624											OREG0019057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	103	59					0	0	6.4e-05	0	0
ZNF251	90987	broad.mit.edu	37	8	145947718	145947718	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr8:145947718G>A	uc003zdv.3	-	5	1583	c.1327C>T	c.(1327-1329)CGT>TGT	p.R443C		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	443	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		GAACTCCGACGAAAGGCTTTG	0.488													47	85					0	0	0.00285205	0	0
GLIS3	169792	broad.mit.edu	37	9	4286371	4286371	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:4286371C>T	uc003zhx.1	-	2	768	c.55G>A	c.(55-57)GGG>AGG	p.G19R	GLIS3_uc003zic.1_Missense_Mutation_p.G19R|GLIS3_uc003zie.1_Missense_Mutation_p.G19R|GLIS3_uc010mhh.1_Intron|GLIS3_uc003zid.1_5'UTR|GLIS3_uc010mhi.1_Intron|GLIS3_uc003zif.1_5'UTR|GLIS3_uc003zig.1_Intron|GLIS3_uc003zih.1_Intron|GLIS3_uc003zii.1_Missense_Mutation_p.G19R	NM_001042413	NP_001035878	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform a	Error:Variant_position_missing_in_Q8NEA6_after_alignment					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		ATCCTAGGCCCCTGTGGGGTT	0.562													34	2					0	0	0.0024448	0	0
IFNB1	3456	broad.mit.edu	37	9	21077570	21077570	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:21077570C>T	uc003zok.2	-	1	374	c.299G>A	c.(298-300)TGG>TAG	p.W100*		NM_002176	NP_002167	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast precursor	100					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			ovary(1)|breast(1)|kidney(1)	3				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	AGTCTCATTCCAGCCAGTGCT	0.443													71	9					0	0	0.000781405	0	0
TMEM215	401498	broad.mit.edu	37	9	32784861	32784861	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:32784861G>A	uc003zri.3	+	2	1045	c.680G>A	c.(679-681)GGC>GAC	p.G227D		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	227						integral to membrane					0						CAGATACAAGGCAGGTGGGAC	0.473													33	4					0	0	0.0024448	0	0
C9orf131	138724	broad.mit.edu	37	9	35044082	35044082	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:35044082G>A	uc003zvw.2	+	2	1485	c.1456G>A	c.(1456-1458)GGC>AGC	p.G486S	C9orf131_uc003zvu.2_Missense_Mutation_p.G438S|C9orf131_uc003zvv.2_Missense_Mutation_p.G413S|C9orf131_uc003zvx.2_Missense_Mutation_p.G451S	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	486											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TCTAGTAATGGGCCCCCAGGG	0.537													49	8					0	0	0.000781405	0	0
FBXO10	26267	broad.mit.edu	37	9	37521630	37521630	+	Missense_Mutation	SNP	G	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:37521630G>C	uc004aab.2	-	8	2185	c.2136C>G	c.(2134-2136)GAC>GAG	p.D712E	FBXO10_uc004aac.2_Missense_Mutation_p.D728E|FBXO10_uc004aad.2_Missense_Mutation_p.D262E	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	712						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		GCAGTGGGTCGTCCTCCTTCT	0.562													13	3					0	0	0.00185496	0	0
SHB	6461	broad.mit.edu	37	9	37955894	37955894	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:37955894G>A	uc004aax.2	-	4	1780	c.1212C>T	c.(1210-1212)CCC>CCT	p.P404P		NM_003028	NP_003019	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein	404	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|skin(1)	3		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		GCTTCTCCAGGGGGACGGCAG	0.527													24	3					0	0	0.001512	0	0
ZNF658	26149	broad.mit.edu	37	9	40773090	40773090	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:40773090G>A	uc004abs.2	-	5	2337	c.2185C>T	c.(2185-2187)CTT>TTT	p.L729F	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.L729F	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	729	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TGTGCTCTAAGGGCTGAATTA	0.418													113	17					0	0	0.000781405	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71549895	71549895	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:71549895G>A	uc004agu.2	+	13	1596	c.1291G>A	c.(1291-1293)GAA>AAA	p.E431K	PIP5K1B_uc011lrq.1_Missense_Mutation_p.E431K|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	431						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		AATTAGCCAGGAATGGAAGGA	0.428													24	12					0	0	0.000586117	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71555568	71555568	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:71555568G>A	uc004agu.2	+	14	1669	c.1364G>A	c.(1363-1365)GGA>GAA	p.G455E	PIP5K1B_uc011lrq.1_Missense_Mutation_p.G455E|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	455						endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		CTAGCCCTGGGATCCCGACAC	0.423													83	12					0	0	0.000781405	0	0
APBA1	320	broad.mit.edu	37	9	72055996	72055996	+	Silent	SNP	G	A	A	rs143924269	by1000genomes	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:72055996G>A	uc004ahh.2	-	11	2493	c.2217C>T	c.(2215-2217)ATC>ATT	p.I739I		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	739	PDZ 1.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GACATCTCACGATATTCAGCT	0.458													48	6					0	0	0.000781405	0	0
PCSK5	5125	broad.mit.edu	37	9	78804657	78804657	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:78804657A>G	uc004ajz.2	+	20	3159	c.2621A>G	c.(2620-2622)AAG>AGG	p.K874R	PCSK5_uc004aka.2_RNA|PCSK5_uc004akb.2_Missense_Mutation_p.K148R	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	874	PLAC.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GCCATTTGCAAGGATGGTGAG	0.408													34	5					0	0	0.00283554	0	0
FLJ43859	389761	broad.mit.edu	37	9	84547517	84547517	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:84547517C>T	uc004amh.2	+	4	2527	c.2441C>T	c.(2440-2442)TCA>TTA	p.S814L	uc004ami.1_Intron|uc004amj.1_5'Flank	NM_001145197	NP_001138669	Q6ZUB0	YI020_HUMAN	hypothetical protein LOC389761	814						integral to membrane					0						GGGAATGATTCAGGGGTGAGA	0.458													14	34					0	0	0.00278032	0	0
C9orf79	286234	broad.mit.edu	37	9	90499983	90499983	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:90499983C>T	uc004app.3	+	4	616	c.581C>T	c.(580-582)CCC>CTC	p.P194L	C9orf79_uc004apo.1_Intron	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	chromosome 9 open reading frame 79	194	Pro-rich.					integral to membrane				ovary(3)	3						CCACCAGCTCCCCCAGCTCCT	0.637													40	10					0	0	0.0025221	0	0
SHC3	53358	broad.mit.edu	37	9	91666967	91666967	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:91666967G>A	uc004aqg.2	-	7	1254	c.947C>T	c.(946-948)CCC>CTC	p.P316L		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	316	PID.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						ATGGAGAGCGGGAATCTTGGT	0.488													51	8					0	0	0.000781405	0	0
ROR2	4920	broad.mit.edu	37	9	94499761	94499762	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:94499761_94499762CC>TT	uc004arj.1	-	5	732_733	c.533_534GG>AA	c.(532-534)CGG>CAA	p.R178Q	ROR2_uc004ari.1_Missense_Mutation_p.R38Q|ROR2_uc004ark.2_Missense_Mutation_p.R178Q	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	178	FZ.|Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						AGGCAATTCCCCGGTAAGGCTG	0.53													36	5					0	0	6.4e-05	0	0
ROR2	4920	broad.mit.edu	37	9	94499787	94499787	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:94499787C>T	uc004arj.1	-	5	707	c.508G>A	c.(508-510)GAG>AAG	p.E170K	ROR2_uc004ari.1_Missense_Mutation_p.E30K|ROR2_uc004ark.2_Missense_Mutation_p.E170K	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	170	FZ.|Extracellular (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						AACCCATCCTCGTGGTAATCA	0.502													26	5					0	0	0.00178596	0	0
WNK2	65268	broad.mit.edu	37	9	96055405	96055405	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:96055405G>A	uc004ati.1	+	23	5769	c.5769G>A	c.(5767-5769)TCG>TCA	p.S1923S	WNK2_uc011lud.1_Silent_p.S1886S|WNK2_uc004atj.2_Silent_p.S1886S|WNK2_uc004atk.2_Silent_p.S1523S|WNK2_uc004atl.1_Silent_p.S480S	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1923					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						ACAATGATTCGGAGCTCGAGG	0.617													18	0					0	0	0.00152264	0	0
PTPDC1	138639	broad.mit.edu	37	9	96860102	96860102	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:96860102C>T	uc004auf.1	+	7	1432	c.1092C>T	c.(1090-1092)TCC>TCT	p.S364S	PTPDC1_uc004aug.1_Silent_p.S364S|PTPDC1_uc004auh.1_Silent_p.S416S|PTPDC1_uc010mrj.1_Silent_p.S418S|PTPDC1_uc010mri.1_Silent_p.S416S	NM_177995	NP_818931	A2A3K4	PTPC1_HUMAN	protein tyrosine phosphatase domain containing 1	364							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1						TGATTTTCTCCAATGAGCAAC	0.488													62	7					0	0	0.000781405	0	0
CDC14B	8555	broad.mit.edu	37	9	99381652	99381652	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:99381652C>T	uc004awj.2	-	1	461	c.9G>A	c.(7-9)CGG>CGA	p.R3R	CDC14B_uc004awk.2_Silent_p.R3R|CDC14B_uc004awl.2_RNA	NM_033331	NP_201588	O60729	CC14B_HUMAN	CDC14 homolog B isoform 2	3	Nucleolar localization signal (Probable).				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GCTCGCTTTTCCGCTTCATGG	0.532													6	1					0	0	0.000157383	0	0
ZNF510	22869	broad.mit.edu	37	9	99521932	99521932	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:99521932G>A	uc004awn.1	-	6	1369	c.1180C>T	c.(1180-1182)CGC>TGC	p.R394C	ZNF510_uc004awo.1_Missense_Mutation_p.R394C	NM_014930	NP_055745	Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				CTTCTTCGGCGAACTCTGTGA	0.398													91	17					0	0	0.000781405	0	0
TDRD7	23424	broad.mit.edu	37	9	100194381	100194381	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:100194381C>T	uc004axj.2	+	4	649	c.424C>T	c.(424-426)CCG>TCG	p.P142S	TDRD7_uc011lux.1_Missense_Mutation_p.P68S	NM_014290	NP_055105	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	142					lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			ovary(2)|pancreas(1)	3		Acute lymphoblastic leukemia(62;0.158)				TAATCCAGCACCGTTAAGAGA	0.388													55	10					0	0	0.000781405	0	0
CORO2A	7464	broad.mit.edu	37	9	100897226	100897226	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:100897226C>T	uc004ayl.2	-	4	596	c.330G>A	c.(328-330)TGG>TGA	p.W110*	CORO2A_uc004aym.2_Nonsense_Mutation_p.W110*	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	110	WD 1.				actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				TGGGGATGCTCCAGATCTTAA	0.632													42	5					0	0	0.000781405	0	0
OR13C5	138799	broad.mit.edu	37	9	107361416	107361417	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:107361416_107361417GG>AA	uc011lvp.1	-	1	278_279	c.278_279CC>TT	c.(277-279)TCC>TTT	p.S93F		NM_001004482	NP_001004482	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C,	93	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4						AGCCAGAAAGGGAAATGGTCTT	0.515													14	2					0	0	6.4e-05	0	0
ZNF462	58499	broad.mit.edu	37	9	109694806	109694806	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:109694806C>T	uc004bcz.2	+	5	6381	c.6092C>T	c.(6091-6093)TCG>TTG	p.S2031L	ZNF462_uc010mto.2_Missense_Mutation_p.S1940L|ZNF462_uc004bda.2_Missense_Mutation_p.S1939L|ZNF462_uc011lvz.1_5'Flank	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2031	C2H2-type 19.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CAGTATTGCTCGTTTGTTTCT	0.522													31	1					0	0	0.000692331	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617744	111617744	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:111617744G>A	uc004bdi.2	-	1	532	c.467C>T	c.(466-468)CCC>CTC	p.P156L		NM_006686	NP_006677	Q9Y614	ACL7B_HUMAN	actin-like 7B	156						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			pancreas(1)	1						GTTGCTGCTGGGGCTGAGCGG	0.612													49	3					0	0	0.000781405	0	0
SVEP1	79987	broad.mit.edu	37	9	113169739	113169739	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:113169739G>A	uc010mtz.2	-	38	8478	c.8141C>T	c.(8140-8142)TCA>TTA	p.S2714L	SVEP1_uc010mty.2_Missense_Mutation_p.S640L	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	2714	Sushi 21.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						ACATTCAATTGAAATGCAGGA	0.463													80	12					0	0	0.000781405	0	0
OR2K2	26248	broad.mit.edu	37	9	114089881	114089881	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:114089881C>T	uc011lwp.1	-	1	833	c.833G>A	c.(832-834)GGA>GAA	p.G278E		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	307	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GGTAAGCACTCCGTAAAGCAA	0.378													36	4					0	0	0.000814825	0	0
OR2K2	26248	broad.mit.edu	37	9	114090351	114090351	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:114090351G>A	uc011lwp.1	-	1	363	c.363C>T	c.(361-363)GAC>GAT	p.D121D		NM_205859	NP_995581	Q8NGT1	OR2K2_HUMAN	olfactory receptor, family 2, subfamily K,	150	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCACATAACGGTCATATGCCA	0.532													41	8					0	0	0.00170553	0	0
KIAA1958	158405	broad.mit.edu	37	9	115421780	115421780	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:115421780C>T	uc004bgf.1	+	4	1757	c.1582C>T	c.(1582-1584)CGC>TGC	p.R528C	KIAA1958_uc011lwx.1_Missense_Mutation_p.R556C	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	528										skin(1)	1						CGCGCGTTCTCGCAACATCGT	0.572													12	2					0	0	0.00244969	0	0
FKBP15	23307	broad.mit.edu	37	9	115940928	115940928	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:115940928C>T	uc004bgs.2	-	20	2186	c.2068G>A	c.(2068-2070)GTG>ATG	p.V690M	FKBP15_uc010muu.1_Missense_Mutation_p.V754M|FKBP15_uc004bgr.2_Missense_Mutation_p.V127M|FKBP15_uc011lxc.1_Missense_Mutation_p.V271M|FKBP15_uc011lxd.1_Missense_Mutation_p.V622M|FKBP15_uc010mut.1_Missense_Mutation_p.V558M	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	690	Potential.				endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						TTTGCCTGCACTTTGGTGAGC	0.463													10	1					0	0	0.000978159	0	0
KIF12	113220	broad.mit.edu	37	9	116854270	116854270	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:116854270C>T	uc004bif.2	-	16	1651	c.1413G>A	c.(1411-1413)GGG>GGA	p.G471G	KIF12_uc004big.2_RNA	NM_138424	NP_612433	Q96FN5	KIF12_HUMAN	kinesin family member 12	604					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GGTTTGGAACCCCGGCCCCAC	0.667													25	2					0	0	0.000586117	0	0
COL27A1	85301	broad.mit.edu	37	9	117051536	117051536	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:117051536C>T	uc011lxl.1	+	45	4167	c.4167C>T	c.(4165-4167)CCC>CCT	p.P1389P	COL27A1_uc004bii.2_RNA	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1389	Pro-rich.|Collagen-like 13.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						ATCCGGGACCCCGGGGGTGGC	0.677													7	2					0	0	0.000274275	0	0
TLR4	7099	broad.mit.edu	37	9	120475851	120475851	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:120475851C>T	uc004bjz.2	+	3	1736	c.1445C>T	c.(1444-1446)TCT>TTT	p.S482F	TLR4_uc004bka.2_Missense_Mutation_p.S442F|TLR4_uc004bkb.2_Missense_Mutation_p.S282F	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	482	LRR 15.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						GCTGGCAATTCTTTCCAGGAA	0.448													49	6					0	0	0.000781405	0	0
CEP110	11064	broad.mit.edu	37	9	123914842	123914842	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:123914842C>T	uc004bkx.1	+	24	4074	c.4043C>T	c.(4042-4044)TCC>TTC	p.S1348F	CEP110_uc004bla.1_Missense_Mutation_p.S796F|CEP110_uc010mvo.1_Missense_Mutation_p.S17F|CEP110_uc004blb.1_Missense_Mutation_p.S17F	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1348	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						ATGAGAGCATCCAAGCGGCAG	0.373													51	9					0	0	0.000781405	0	0
PTGS1	5742	broad.mit.edu	37	9	125140259	125140259	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:125140259C>T	uc004bmg.1	+	3	311	c.176C>T	c.(175-177)ACC>ATC	p.T59I	PTGS1_uc011lys.1_Missense_Mutation_p.T34I|PTGS1_uc010mwb.1_5'UTR|PTGS1_uc004bmf.1_Missense_Mutation_p.T59I|PTGS1_uc004bmh.1_5'UTR|PTGS1_uc011lyt.1_5'UTR	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	59	EGF-like.				cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TGTGACTGCACCCGCACGGGC	0.607													29	3					0	0	0.001512	0	0
OR1L4	254973	broad.mit.edu	37	9	125486328	125486328	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:125486328C>T	uc004bmu.1	+	1	60	c.60C>T	c.(58-60)TCC>TCT	p.S20S		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCTCTCTTCCAACCCTAAGC	0.507													5	96					0	0	0.000978159	0	0
OR1L6	392390	broad.mit.edu	37	9	125512186	125512186	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:125512186C>T	uc011lzc.1	+	1	168	c.168C>T	c.(166-168)TCC>TCT	p.S56S		NM_001004453	NP_001004453	Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L,	56	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCTCTCTTCCAACCCTCAGC	0.542													74	15					0	0	0.000781405	0	0
NR6A1	2649	broad.mit.edu	37	9	127298251	127298251	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:127298251G>A	uc004bor.1	-	7	1163	c.985C>T	c.(985-987)CTG>TTG	p.L329L	NR6A1_uc004boq.1_Silent_p.L324L|NR6A1_uc010mwq.1_Silent_p.L325L	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	329					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GAAGACAGCAGGATTAGCTCC	0.512													44	7					0	0	0.00222228	0	0
FAM125B	89853	broad.mit.edu	37	9	129143402	129143402	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:129143402C>T	uc004bqh.1	+	3	345	c.264C>T	c.(262-264)TCC>TCT	p.S88S	FAM125B_uc004bqg.1_Silent_p.S88S|FAM125B_uc011lzy.1_Silent_p.S73S|FAM125B_uc010mxd.2_Silent_p.S81S|FAM125B_uc011lzz.1_Silent_p.S81S	NM_033446	NP_258257	Q9H7P6	F125B_HUMAN	hypothetical protein LOC89853 isoform 1	88	MABP.				protein transport	late endosome membrane					0						TATTTAAATCCAAGGTTACCA	0.423													16	3					0	0	0.00152264	0	0
FAM125B	89853	broad.mit.edu	37	9	129154430	129154430	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:129154430C>T	uc004bqh.1	+	5	576	c.495C>T	c.(493-495)ATC>ATT	p.I165I	FAM125B_uc004bqg.1_Silent_p.I165I|FAM125B_uc011lzy.1_Silent_p.I150I|FAM125B_uc010mxd.2_Silent_p.I158I|FAM125B_uc011lzz.1_Silent_p.I158I	NM_033446	NP_258257	Q9H7P6	F125B_HUMAN	hypothetical protein LOC89853 isoform 1	165	MABP.				protein transport	late endosome membrane					0						ACATTCGGATCATGGGCCGGA	0.502													72	10					0	0	0.000781405	0	0
SH2D3C	10044	broad.mit.edu	37	9	130536329	130536329	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:130536329G>A	uc004bsc.2	-	2	597	c.455C>T	c.(454-456)CCT>CTT	p.P152L	SH2D3C_uc004bsa.2_5'Flank|SH2D3C_uc004bsb.2_5'Flank|SH2D3C_uc004bsd.1_Missense_Mutation_p.P96L	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	152					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						GGGGACCTCAGGCTTTCTGAT	0.602													33	6					0	0	0.00209593	0	0
NUP188	23511	broad.mit.edu	37	9	131745768	131745768	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:131745768C>T	uc004bws.1	+	19	1922	c.1900C>T	c.(1900-1902)CGT>TGT	p.R634C	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	634					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GACTGATCTTCGTCACACAGG	0.423													19	4					0	0	0.00121646	0	0
NUP214	8021	broad.mit.edu	37	9	134038512	134038512	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:134038512C>T	uc004cag.2	+	19	2786	c.2675C>T	c.(2674-2676)TCC>TTC	p.S892F	NUP214_uc004cah.2_Missense_Mutation_p.S882F|NUP214_uc004cai.2_Missense_Mutation_p.S322F|NUP214_uc004caf.1_Missense_Mutation_p.S881F|NUP214_uc010mzf.2_Missense_Mutation_p.S190F	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	892	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		AAACAGACTTCCCTGTGGAGC	0.493			T	DEK|SET|ABL1	AML|T-ALL								56	8					0	0	0.000781405	0	0
TTF1	7270	broad.mit.edu	37	9	135254449	135254449	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:135254449G>A	uc004cbl.2	-	10	2513	c.2461C>T	c.(2461-2463)CCA>TCA	p.P821S	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.P306S	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	821					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TACTAACCTGGAAAAGTCTTT	0.249													50	16					0	0	0.000781405	0	0
TTF1	7270	broad.mit.edu	37	9	135266135	135266135	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:135266135G>A	uc004cbl.2	-	7	2123	c.2071C>T	c.(2071-2073)CCC>TCC	p.P691S	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.P176S	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	691	Myb-like 2.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		AACTCCTGGGGAGACATCTTC	0.408													97	19					0	0	0.000781405	0	0
DBH	1621	broad.mit.edu	37	9	136505099	136505099	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:136505099G>A	uc004cel.2	+	2	480	c.471G>A	c.(469-471)AAG>AAA	p.K157K		NM_000787	NP_000778	P09172	DOPO_HUMAN	dopamine beta hydroxylase precursor	157	DOMON.|Intragranular (Potential).				hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			ovary(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	GCGACCCCAAGGATTACCTCA	0.587													17	2					0	0	0.00152264	0	0
CARD9	64170	broad.mit.edu	37	9	139262131	139262131	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:139262131C>T	uc004chg.3	-	8	1393	c.1227G>A	c.(1225-1227)GTG>GTA	p.V409V	CARD9_uc011mdw.1_Silent_p.V409V|CARD9_uc011mdx.1_Silent_p.V305V	NM_052813	NP_434700	Q9H257	CARD9_HUMAN	caspase recruitment domain protein 9 isoform 1	409	Potential.				positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			pancreas(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		GCCTGCCCTCCACGGCCAGTA	0.716													12	1					0	0	0.00136819	0	0
NOTCH1	4851	broad.mit.edu	37	9	139390979	139390979	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:139390979C>T	uc004chz.2	-	34	7212	c.7212G>A	c.(7210-7212)CAG>CAA	p.Q2404Q		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2404	Poly-Gln.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.Q2404*(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GGCTTTGCTGCTGCTGGATGT	0.652			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			42	3					0	0	0.00195071	0	0
ABCA2	20	broad.mit.edu	37	9	139905466	139905466	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:139905466G>A	uc011mem.1	-	38	6160	c.6012C>T	c.(6010-6012)CTC>CTT	p.L2004L	ABCA2_uc011mel.1_Silent_p.L2005L|ABCA2_uc004ckl.1_Silent_p.L1935L|ABCA2_uc004ckm.1_Silent_p.L2035L	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	2004	Helical; (Potential).				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TGATGGTCAGGAGGAAGCCCA	0.458													13	3					0	0	0.00185496	0	0
PLCXD1	55344	broad.mit.edu	37	X	205506	205506	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:205506C>T	uc004cpc.2	+	3	546	c.234C>T	c.(232-234)CGC>CGT	p.R78R	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	78	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCATCACGCGCCCTGTCGTGC	0.632													32	8					0	0	0.00283554	0	0
ARSF	416	broad.mit.edu	37	X	3030285	3030285	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:3030285C>T	uc004cre.1	+	11	1682	c.1461C>T	c.(1459-1461)GTC>GTT	p.V487V	ARSF_uc004crf.1_Silent_p.V487V	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	487						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCTGCTATGTCACCTCATTAT	0.478													43	3					0	0	0.000781405	0	0
MXRA5	25878	broad.mit.edu	37	X	3235706	3235706	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:3235706C>T	uc004crg.3	-	6	6173	c.6016G>A	c.(6016-6018)GAA>AAA	p.E2006K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2006	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTCCGGTTTTCGTGCAGGGTG	0.622													25	3					0	0	0.000720815	0	0
MXRA5	25878	broad.mit.edu	37	X	3241568	3241569	+	Nonsense_Mutation	DNP	GG	AA	AA			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:3241568_3241569GG>AA	uc004crg.3	-	5	2314_2315	c.2157_2158CC>TT	c.(2155-2160)GACCAA>GATTAA	p.Q720*		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	720						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AACACCTCTTGGTCCTTTGGAT	0.475													36	1					0	0	6.4e-05	0	0
SHROOM2	357	broad.mit.edu	37	X	9907344	9907344	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:9907344G>A	uc004csu.1	+	8	4339	c.4249G>A	c.(4249-4251)GAG>AAG	p.E1417K	SHROOM2_uc004csv.2_Missense_Mutation_p.E252K|SHROOM2_uc011mic.1_Missense_Mutation_p.E252K|SHROOM2_uc004csw.1_Missense_Mutation_p.E252K	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1417	ASD2.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				GGACCTGCAGGAGCAGCAGGA	0.602													8	1					0	0	0.000274275	0	0
HCCS	3052	broad.mit.edu	37	X	11139886	11139886	+	Missense_Mutation	SNP	G	A	A	rs145499860		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:11139886G>A	uc004cuk.2	+	7	1029	c.763G>A	c.(763-765)GTA>ATA	p.V255I	HCCS_uc004cuj.2_Missense_Mutation_p.V255I|HCCS_uc004cul.1_Missense_Mutation_p.V255I	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	255					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						ACTTTCGGCAGTATGGGACAG	0.413													22	1					0	0	0.00278032	0	0
PIR	8544	broad.mit.edu	37	X	15477785	15477785	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:15477785A>G	uc004cwu.2	-	4	506	c.268T>C	c.(268-270)TTG>CTG	p.L90L	PIR_uc004cwv.2_Silent_p.L90L	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin	90					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					CATACCTGCAAATCTCCTGGG	0.388													118	17					0	0	0.000781405	0	0
ACE2	59272	broad.mit.edu	37	X	15610379	15610379	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:15610379G>A	uc004cxa.1	-	3	580	c.412C>T	c.(412-414)CCA>TCA	p.P138S	ACE2_uc004cxb.2_Missense_Mutation_p.P138S	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	138	Extracellular (Potential).				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	CATTCTTGTGGATTATCTGGG	0.294													126	6					0	0	0.000781405	0	0
SCML1	6322	broad.mit.edu	37	X	17768160	17768160	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:17768160C>T	uc004cyb.2	+	6	775	c.450C>T	c.(448-450)TCC>TCT	p.S150S	SCML1_uc004cyc.2_Silent_p.S123S|SCML1_uc004cyd.2_Silent_p.S29S|SCML1_uc004cye.2_Silent_p.S29S	NM_001037540	NP_001032629	Q9UN30	SCML1_HUMAN	sex comb on midleg-like 1 isoform a	150					anatomical structure morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)	3	Hepatocellular(33;0.183)					AGAATAATTCCCCGAGCAACC	0.498													61	5					0	0	0.000781405	0	0
SCML2	10389	broad.mit.edu	37	X	18276309	18276309	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:18276309G>A	uc004cyl.2	-	10	1285	c.1128C>T	c.(1126-1128)ATC>ATT	p.I376I	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Silent_p.I376I|SCML2_uc011miz.1_Silent_p.I310I|SCML2_uc010nfc.2_Silent_p.I112I	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	376					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					GCAGCTGCTGGATTCTCTTGG	0.483													51	6					0	0	0.000781405	0	0
MAP3K15	389840	broad.mit.edu	37	X	19410163	19410163	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:19410163C>T	uc004czk.1	-	19	2450	c.813G>A	c.(811-813)TCG>TCA	p.S271S	MAP3K15_uc004czj.1_Silent_p.S231S	NM_001001671	NP_001001671	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase	796	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			ovary(3)|lung(2)|stomach(1)|skin(1)	7	Hepatocellular(33;0.183)					CAAGACGTTTCGAGGTTCCAA	0.488													22	0					0	0	0.00278032	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19713846	19713846	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:19713846C>T	uc004czm.2	-	5	720	c.404G>A	c.(403-405)TGG>TAG	p.W135*	SH3KBP1_uc004czl.2_Nonsense_Mutation_p.W98*	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	135	SH3 2.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						ACCTTCCCACCATCCTTCCTC	0.473													36	2					0	0	0.000692331	0	0
CXorf21	80231	broad.mit.edu	37	X	30578385	30578385	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:30578385C>T	uc004dcg.1	-	3	364	c.88G>A	c.(88-90)GAA>AAA	p.E30K		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	30										ovary(1)	1						TCTTCCTTTTCCCCAGCCACC	0.458													26	0					0	0	0.00047179	0	0
DMD	1756	broad.mit.edu	37	X	31222096	31222096	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:31222096G>A	uc004dda.1	-	67	10033	c.9789C>T	c.(9787-9789)GTC>GTT	p.V3263V	DMD_uc004dcq.1_Silent_p.V534V|DMD_uc004dcr.1_Silent_p.V803V|DMD_uc004dcs.1_Silent_p.V803V|DMD_uc004dct.1_Silent_p.V803V|DMD_uc004dcu.1_Silent_p.V803V|DMD_uc004dcv.1_Silent_p.V803V|DMD_uc004dcw.2_Silent_p.V1919V|DMD_uc004dcx.2_Silent_p.V1922V|DMD_uc004dcz.2_Silent_p.V3140V|DMD_uc004dcy.1_Silent_p.V3259V|DMD_uc004ddb.1_Silent_p.V3255V|DMD_uc004dcm.1_Silent_p.V195V|DMD_uc004dcn.1_Silent_p.V195V|DMD_uc004dco.1_Silent_p.V195V|DMD_uc004dcp.1_Silent_p.V195V|DMD_uc011mkb.1_Silent_p.V195V|DMD_uc010ngm.2_Silent_p.V195V	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3263	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AGCAGCTCCGGACACTTGGCT	0.413													30	1					0	0	0.000692331	0	0
FAM47B	170062	broad.mit.edu	37	X	34961603	34961603	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:34961603C>T	uc004ddi.1	+	1	673	c.655C>T	c.(655-657)CGG>TGG	p.R219W		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	219	Pro-rich.									ovary(3)|breast(1)	4						TCCCAAGACTCGGGTGTCCAG	0.667													21	2					0	0	0.00152264	0	0
FAM47B	170062	broad.mit.edu	37	X	34961628	34961628	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:34961628C>T	uc004ddi.1	+	1	698	c.680C>T	c.(679-681)CCT>CTT	p.P227L		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	227	Pro-rich.									ovary(3)|breast(1)	4						CGCCCAGAGCCTCCCAAGACT	0.647													21	2					0	0	0.00188189	0	0
CXorf22	170063	broad.mit.edu	37	X	35985752	35985752	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:35985752C>T	uc004ddj.2	+	10	1676	c.1617C>T	c.(1615-1617)ATC>ATT	p.I539I	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	539										large_intestine(1)|lung(1)|ovary(1)	3						TGCCTTCGATCCGTAATCCCA	0.338													11	2					0	0	0.000978159	0	0
CXorf27	25763	broad.mit.edu	37	X	37850232	37850232	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:37850232C>T	uc004ddt.3	+	1	163	c.140C>T	c.(139-141)TCC>TTC	p.S47F		NM_012274	NP_036406	O75409	HYPM_HUMAN	Huntingtin interacting protein M	47							DNA binding			central_nervous_system(1)	1						AGCCAGAGTTCCTCCACAATA	0.517													27	4					0	0	0.00106085	0	0
RBM10	8241	broad.mit.edu	37	X	47039676	47039676	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:47039676C>T	uc004dhf.2	+	11	1507	c.1128C>T	c.(1126-1128)ACC>ACT	p.T376T	RBM10_uc004dhg.2_Silent_p.T298T|RBM10_uc004dhh.2_Silent_p.T375T|RBM10_uc010nhq.2_Silent_p.T299T|RBM10_uc004dhi.2_Silent_p.T441T	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	376	RRM 2.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						ACGGCAAGACCATCAATGTTG	0.488													9	0					0	0	0.000442599	0	0
SSX8	280659	broad.mit.edu	37	X	52655419	52655419	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:52655419C>T	uc011moa.1	+	4		c.546C>T			SSX8_uc011mob.1_RNA					Homo sapiens cDNA FLJ56587 complete cds, highly similar to Protein SSX8.												0						TGATAATGACCGTAACCGCAG	0.453													46	5					0	0	0.000781405	0	0
PHF8	23133	broad.mit.edu	37	X	53966798	53966798	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:53966798G>A	uc004dsu.2	-	21	2982	c.2909C>T	c.(2908-2910)CCC>CTC	p.P970L	PHF8_uc004dst.2_Missense_Mutation_p.P934L|PHF8_uc004dsv.2_Missense_Mutation_p.P800L|PHF8_uc004dsw.2_Missense_Mutation_p.P833L	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	970					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						AGGAGGCAGGGGTGAGGAGGA	0.582													10	0					0	0	0.000978159	0	0
PHF8	23133	broad.mit.edu	37	X	54022212	54022212	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:54022212G>A	uc004dsu.2	-	12	1418	c.1345C>T	c.(1345-1347)CTG>TTG	p.L449L	PHF8_uc004dst.2_Silent_p.L413L|PHF8_uc004dsv.2_Silent_p.L279L|PHF8_uc004dsw.2_Silent_p.L413L|PHF8_uc004dsx.2_Silent_p.L177L|PHF8_uc004dsy.2_Silent_p.L413L	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	449					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						TGGTCTGGCAGAGCCTGTCAA	0.338													13	3					0	0	0.00185496	0	0
HEPH	9843	broad.mit.edu	37	X	65486392	65486392	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:65486392C>T	uc011moz.1	+	21	3424	c.3364C>T	c.(3364-3366)CTT>TTT	p.L1122F	HEPH_uc004dwn.2_Missense_Mutation_p.L1121F|HEPH_uc004dwo.2_Missense_Mutation_p.L852F|HEPH_uc010nkr.2_Missense_Mutation_p.L930F|HEPH_uc011mpa.1_Missense_Mutation_p.L1122F	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1119	Helical; (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						TAGTGTCACCCTTCTGCTCGT	0.488													35	1					0	0	0.000953801	0	0
OPHN1	4983	broad.mit.edu	37	X	67333082	67333082	+	Splice_Site	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:67333082C>T	uc004dww.3	-	17	1656	c.1362_splice	c.e17-1	p.R454_splice	OPHN1_uc011mpg.1_Splice_Site_p.R454_splice	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1						axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						AGAAAGATTCCTGAAATGAAT	0.418													8	1					0	0	0.000274275	0	0
CXCR3	2833	broad.mit.edu	37	X	70836566	70836566	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:70836566C>T	uc004eaf.2	-	2	824	c.756G>A	c.(754-756)CGG>CGA	p.R252R	BCYRN1_uc011mpt.1_Intron|CXCR3_uc011mpx.1_Silent_p.R299R	NM_001504	NP_001495	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3 isoform A	252	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			ovary(2)|central_nervous_system(1)	3	Renal(35;0.156)					GCCGCATGGCCCGCAGGCGCC	0.662													5	1					0	0	0.00116845	0	0
TSIX	9383	broad.mit.edu	37	X	73041479	73041479	+	RNA	SNP	C	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:73041479C>A	uc004ebn.2	+	1		c.29440C>A			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						GGCAGGTTGCCCTTAAAACAG	0.428													12	0					4.3838e-07	1.49227e-06	0.00185496	1	0
TSIX	9383	broad.mit.edu	37	X	73046495	73046495	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:73046495C>T	uc004ebn.2	+	1		c.34456C>T			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						CTTGGGATTTCCCCAGGTCTT	0.443													53	6					0	0	0.000781405	0	0
TSIX	9383	broad.mit.edu	37	X	73046552	73046552	+	RNA	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:73046552C>T	uc004ebn.2	+	1		c.34513C>T			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						CTCCAGATTCCGGCCGTTAGT	0.507													49	8					0	0	0.000781405	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962753	73962753	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:73962753G>A	uc004eby.2	-	3	2256	c.1639C>T	c.(1639-1641)CGC>TGC	p.R547C		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	547					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CCTTTAAAGCGATTAATGATG	0.403													27	3					0	0	0.00127121	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913819	77913819	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:77913819G>A	uc004edc.1	-	2	395	c.99C>T	c.(97-99)CTC>CTT	p.L33L		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	33							nucleic acid binding|zinc ion binding			ovary(1)	1						TCTGGGCCTGGAGAGCAGCAT	0.522													11	3					0	0	0.00185496	0	0
LPAR4	2846	broad.mit.edu	37	X	78011239	78011239	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:78011239C>T	uc010nme.2	+	2	1278	c.873C>T	c.(871-873)ATC>ATT	p.I291I		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	291	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TTGCAAAGATCATGTACCCAA	0.418													18	1					0	0	0.000958276	0	0
GPR174	84636	broad.mit.edu	37	X	78426883	78426883	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:78426883C>T	uc004edg.1	+	1	415	c.379C>T	c.(379-381)CAT>TAT	p.H127Y		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	127	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						CTTTCGCTTCCATGACTGCAA	0.458										HNSCC(63;0.18)			70	16					0	0	0.000781405	0	0
FAM46D	169966	broad.mit.edu	37	X	79698131	79698131	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:79698131G>A	uc004edl.1	+	5	427	c.93G>A	c.(91-93)GGG>GGA	p.G31G	FAM46D_uc004edm.1_Silent_p.G31G	NM_152630	NP_689843	Q8NEK8	FA46D_HUMAN	hypothetical protein LOC169966	31										lung(2)	2						ATGGAAAGGGGAATTTCCCCA	0.368													21	3					0	0	0.00121646	0	0
ZNF711	7552	broad.mit.edu	37	X	84526436	84526436	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:84526436C>T	uc004eeo.2	+	9	2235	c.1888C>T	c.(1888-1890)CGT>TGT	p.R630C	ZNF711_uc004eep.2_Missense_Mutation_p.R630C|ZNF711_uc004eeq.2_Missense_Mutation_p.R676C|ZNF711_uc011mqy.1_Missense_Mutation_p.R229C	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	630	C2H2-type 8.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						AGGTTTTCATCGTCCTTCTGA	0.403													11	0					0	0	0.000978159	0	0
ZNF711	7552	broad.mit.edu	37	X	84526691	84526691	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:84526691G>A	uc004eeo.2	+	9	2490	c.2143G>A	c.(2143-2145)GAT>AAT	p.D715N	ZNF711_uc004eep.2_Missense_Mutation_p.D715N|ZNF711_uc004eeq.2_Missense_Mutation_p.D761N|ZNF711_uc011mqy.1_Missense_Mutation_p.D314N	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	715	C2H2-type 11.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						CAGCACTACAGATGCATCTGG	0.378													25	3					0	0	0.000586117	0	0
PCDH19	57526	broad.mit.edu	37	X	99551454	99551454	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:99551454G>A	uc010nmz.2	-	6	4944	c.3268C>T	c.(3268-3270)CCA>TCA	p.P1090S	PCDH19_uc004efw.3_Missense_Mutation_p.P1042S|PCDH19_uc004efx.3_Missense_Mutation_p.P1043S	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	1090	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						TCACGGGCTGGGGGAGCCAGG	0.577													28	5					0	0	0.00106085	0	0
NXF5	55998	broad.mit.edu	37	X	101096486	101096486	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:101096486C>T	uc011mrk.1	-	6	645	c.285G>A	c.(283-285)AAG>AAA	p.K95K	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	95					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TCAACTTATTCTTCACAGAGT	0.473													29	4					0	0	0.000814825	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382330	101382330	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:101382330G>A	uc004eip.2	+	3	747	c.528G>A	c.(526-528)AGG>AGA	p.R176R		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						ACATGGCTAGGGTGGAGGATA	0.428													59	7					0	0	0.000781405	0	0
TEX13A	56157	broad.mit.edu	37	X	104464876	104464876	+	Nonsense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:104464876C>T	uc004ema.2	-	2	318	c.206G>A	c.(205-207)TGG>TAG	p.W69*	IL1RAPL2_uc004elz.1_Intron|TEX13A_uc004emb.2_Nonsense_Mutation_p.W69*	NM_031274	NP_112564	Q9BXU3	TX13A_HUMAN	testis expressed sequence 13A	69						intracellular	zinc ion binding			ovary(2)	2						CAGGCTGCCCCAGGTGCAGGC	0.587													12	4					0	0	0.000978159	0	0
RIPPLY1	92129	broad.mit.edu	37	X	106144060	106144060	+	Missense_Mutation	SNP	C	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:106144060C>G	uc004emr.1	-	4	419	c.375G>C	c.(373-375)CAG>CAC	p.Q125H	MORC4_uc004emp.3_Intron|CLDN2_uc004emq.1_Intron|RIPPLY1_uc004ems.1_Missense_Mutation_p.Q78H	NM_138382	NP_612391	Q0D2K3	RIPP1_HUMAN	ripply1 homolog	125	Ripply homology domain.				negative regulation of transcription, DNA-dependent|somite rostral/caudal axis specification|somite specification|transcription, DNA-dependent	nucleus					0						TGATGGTTGCCTGGACAGGAA	0.403													14	2					0	0	0.000422831	0	0
CLDN2	9075	broad.mit.edu	37	X	106171786	106171786	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:106171786G>A	uc004emq.1	+	2	847	c.328G>A	c.(328-330)GAA>AAA	p.E110K	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Missense_Mutation_p.E110K	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	110	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						CTTCTGCCAGGAATCCCGAGC	0.547													38	4					0	0	0.00170553	0	0
VSIG1	340547	broad.mit.edu	37	X	107310195	107310195	+	Silent	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:107310195A>G	uc004eno.2	+	3	404	c.243A>G	c.(241-243)GTA>GTG	p.V81V	VSIG1_uc011msk.1_Silent_p.V117V	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	81	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						GACAAGCTGTAGCCATCGGGC	0.428													22	2					0	0	0.00278032	0	0
PSMD10	5716	broad.mit.edu	37	X	107331010	107331010	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:107331010G>A	uc004enp.1	-	4	531	c.433C>T	c.(433-435)CGG>TGG	p.R145W	PSMD10_uc004enq.1_Missense_Mutation_p.R145W|PSMD10_uc010nph.1_Missense_Mutation_p.R96W	NM_002814	NP_002805	O75832	PSD10_HUMAN	proteasome 26S non-ATPase subunit 10 isoform 1	145	ANK 5.|Interaction with RELA.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cytoplasmic sequestering of NF-kappaB|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of MAPKKK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of release of cytochrome c from mitochondria|negative regulation of transcription from RNA polymerase II promoter|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of cell growth|positive regulation of cyclin-dependent protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|proteasome regulatory particle assembly|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus|proteasome regulatory particle	transcription factor binding			ovary(1)	1						GCTGCTGCCCGGTGCATTGCT	0.458													44	6					0	0	0.000781405	0	0
CAPN6	827	broad.mit.edu	37	X	110507123	110507123	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:110507123C>T	uc004epc.1	-	2	210	c.42G>A	c.(40-42)CAG>CAA	p.Q14Q	CAPN6_uc011msu.1_5'UTR	NM_014289	NP_055104	Q9Y6Q1	CAN6_HUMAN	calpain 6	14					microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|skin(1)	6						GCTTCAGTTCCTGGTATTTCT	0.408													35	6					0	0	0.000953801	0	0
KLHL13	90293	broad.mit.edu	37	X	117043651	117043651	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:117043651C>T	uc004eql.2	-	5	1041	c.979G>A	c.(979-981)GTT>ATT	p.V327I	KLHL13_uc004eqk.2_Missense_Mutation_p.V276I|KLHL13_uc011mtn.1_Missense_Mutation_p.V167I|KLHL13_uc011mto.1_Missense_Mutation_p.V321I|KLHL13_uc011mtp.1_Missense_Mutation_p.V329I|KLHL13_uc004eqm.2_Missense_Mutation_p.V276I|KLHL13_uc011mtq.1_Missense_Mutation_p.V311I	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	327					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						GACTGCATAACTGGCTGCATA	0.453													38	4					0	0	0.00170553	0	0
DOCK11	139818	broad.mit.edu	37	X	117731477	117731477	+	Missense_Mutation	SNP	C	T	T	rs138683152	byFrequency	TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:117731477C>T	uc004eqp.2	+	21	2410	c.2347C>T	c.(2347-2349)CCA>TCA	p.P783S	DOCK11_uc004eqq.2_Missense_Mutation_p.P549S	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	783	DHR-1.				blood coagulation	cytosol	GTP binding			ovary(3)	3						CAATCTTCCCCCAGGCTACTT	0.403													31	4					0	0	0.0024448	0	0
ATP1B4	23439	broad.mit.edu	37	X	119513344	119513344	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:119513344C>T	uc004esr.2	+	8	1013	c.929C>T	c.(928-930)CCC>CTC	p.P310L	ATP1B4_uc004esq.2_Missense_Mutation_p.P306L|ATP1B4_uc011mtx.1_Missense_Mutation_p.P275L|ATP1B4_uc011mty.1_Missense_Mutation_p.P267L	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	310	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						TACACATCCCCCTTGGTGGCA	0.473													36	5					0	0	0.00148497	0	0
ODZ1	10178	broad.mit.edu	37	X	123839007	123839007	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:123839007G>A	uc004euj.2	-	5	935	c.871C>T	c.(871-873)CCT>TCT	p.P291S	ODZ1_uc011muj.1_Missense_Mutation_p.P291S|ODZ1_uc010nqy.2_Missense_Mutation_p.P291S	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	291	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GGCCTGGGAGGGGGCGAGTAC	0.527													40	7					0	0	0.00222228	0	0
FAM45B	55855	broad.mit.edu	37	X	129629636	129629636	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:129629636G>A	uc010nrh.2	+	1	722	c.504G>A	c.(502-504)ATG>ATA	p.M168I	uc004evu.2_Intron	NM_207009	NP_996892			hypothetical protein LOC404636											skin(1)	1				all cancers(201;0.0293)		AGTTTGGAATGGAAACTGTTA	0.468													24	4					0	0	0.00106085	0	0
RBMX	27316	broad.mit.edu	37	X	135956521	135956521	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:135956521C>T	uc004fae.1	-	9	1166	c.956G>A	c.(955-957)GGA>GAA	p.G319E	RBMX_uc004fac.1_5'Flank|RBMX_uc011mwf.1_Intron|RBMX_uc004fad.1_3'UTR|RBMX_uc011mwg.1_Missense_Mutation_p.G280E|RBMX_uc004faf.1_Missense_Mutation_p.G180E|RBMX_uc010nsf.1_Missense_Mutation_p.G280E|RBMX_uc004fag.1_Missense_Mutation_p.G191E	NM_002139	NP_002130	P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked isoform 1	319						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TCCACCATATCCGTCACGTGA	0.542													18	66					0	0	0.00127121	0	0
CDR1	1038	broad.mit.edu	37	X	139865906	139865906	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:139865906G>A	uc004fbg.1	-	1	818	c.626C>T	c.(625-627)TCC>TTC	p.S209F	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	209											0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				ACATCTTCCGGAAAAAATCCA	0.443													51	7					0	0	0.000781405	0	0
SPANXC	64663	broad.mit.edu	37	X	140336564	140336564	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:140336564C>T	uc004fbk.2	-	1	83	c.27G>A	c.(25-27)GGG>GGA	p.G9G	SPANXC_uc004fbl.2_Intron	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X	9						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					TCCTCTTCACCCCGCCGGCAC	0.383													54	10					0	0	0.000781405	0	0
MAGEC3	139081	broad.mit.edu	37	X	140953310	140953310	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:140953310G>A	uc011mwp.1	+	2	177	c.177G>A	c.(175-177)CTG>CTA	p.L59L		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	59										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTGGGCATCTGAGGGAGGTGA	0.507													32	8					0	0	0.000953801	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969501	140969501	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:140969501G>A	uc011mwp.1	+	4	828	c.828G>A	c.(826-828)CTG>CTA	p.L276L		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	276	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACCGCCTCCTGATTCTTATTC	0.507													44	7					0	0	0.0025221	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994871	140994871	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:140994871C>T	uc004fbt.2	+	4	1967	c.1681C>T	c.(1681-1683)CCT>TCT	p.P561S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	561							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CTCCCTATCTCCTCACTACTT	0.572										HNSCC(15;0.026)			89	22					0	0	0.000781405	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995998	140995998	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:140995998G>A	uc004fbt.2	+	4	3094	c.2808G>A	c.(2806-2808)ACG>ACA	p.T936T	MAGEC1_uc010nsl.1_Silent_p.T3T	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	936	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGATGCTGACGAATGTCATCA	0.468										HNSCC(15;0.026)			60	12					0	0	0.000781405	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905507	144905507	+	Missense_Mutation	SNP	A	G	G			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:144905507A>G	uc004fcd.2	+	5	2554	c.1564A>G	c.(1564-1566)ATC>GTC	p.I522V	SLITRK2_uc010nsp.2_Missense_Mutation_p.I522V|SLITRK2_uc010nso.2_Missense_Mutation_p.I522V|SLITRK2_uc011mwq.1_Missense_Mutation_p.I522V|SLITRK2_uc011mwr.1_Missense_Mutation_p.I522V|SLITRK2_uc011mws.1_Missense_Mutation_p.I522V|SLITRK2_uc004fcg.2_Missense_Mutation_p.I522V|SLITRK2_uc011mwt.1_Missense_Mutation_p.I522V	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	522	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCCGGCTTTCATCCAGATAGA	0.498													22	5					0	0	0.00229938	0	0
MTMR1	8776	broad.mit.edu	37	X	149912857	149912857	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:149912857C>T	uc004fei.2	+	12	1609	c.1474C>T	c.(1474-1476)CAT>TAT	p.H492Y	MTMR1_uc011mya.1_Missense_Mutation_p.H398Y|MTMR1_uc004feh.1_Missense_Mutation_p.H500Y|MTMR1_uc004fej.2_RNA|MTMR1_uc010ntf.2_RNA	NM_003828	NP_003819	Q13613	MTMR1_HUMAN	myotubularin-related protein 1	492	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TAATGACAACCATGCGGATGC	0.368													41	6					0	0	0.000781405	0	0
PASD1	139135	broad.mit.edu	37	X	150832763	150832763	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:150832763G>A	uc004fev.3	+	11	1346	c.1014G>A	c.(1012-1014)ATG>ATA	p.M338I		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	338						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGCCTGATGGATCCAGTGG	0.597													24	0					0	0	0.000586117	0	0
PNCK	139728	broad.mit.edu	37	X	152936627	152936627	+	Silent	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:152936627G>A	uc011myu.1	-	8	1068	c.882C>T	c.(880-882)CCC>CCT	p.P294P	PNCK_uc011myt.1_Silent_p.P228P|PNCK_uc004fia.2_Silent_p.P246P|PNCK_uc004fhz.3_Silent_p.P109P|PNCK_uc010nuh.2_3'UTR|PNCK_uc011myv.1_3'UTR|PNCK_uc011myw.1_3'UTR	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	211	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGTCGTAGAAGGGGGGGTACC	0.592													16	4					0	0	0.000566183	0	0
L1CAM	3897	broad.mit.edu	37	X	153130444	153130444	+	Missense_Mutation	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:153130444C>T	uc004fjb.2	-	22	2986	c.2878G>A	c.(2878-2880)GAG>AAG	p.E960K	L1CAM_uc004fjc.2_Missense_Mutation_p.E960K|L1CAM_uc010nuo.2_Missense_Mutation_p.E955K	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	960	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGCCCCCCTCATCCACTGTG	0.677													24	3					0	0	0.000878237	0	0
L1CAM	3897	broad.mit.edu	37	X	153135651	153135651	+	Missense_Mutation	SNP	G	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:153135651G>A	uc004fjb.2	-	8	959	c.851C>T	c.(850-852)CCA>CTA	p.P284L	L1CAM_uc004fjc.2_Missense_Mutation_p.P284L|L1CAM_uc010nuo.2_Missense_Mutation_p.P279L|L1CAM_uc004fjd.1_Missense_Mutation_p.P98L|L1CAM_uc004fje.1_Missense_Mutation_p.P279L	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	284	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACGGTCGGCTGGCATGGGGCC	0.617													76	9					0	0	0.000781405	0	0
F8	2157	broad.mit.edu	37	X	154133156	154133156	+	Missense_Mutation	SNP	T	C	C			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:154133156T>C	uc004fmt.2	-	16	5687	c.5516A>G	c.(5515-5517)CAA>CGA	p.Q1839R	F8_uc010nvi.1_5'UTR	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1839	F5/8 type A 3.|Plastocyanin-like 5.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CATATGATGTTGCACTTTCCA	0.413													36	5					0	0	0.000953801	0	0
F8	2157	broad.mit.edu	37	X	154182201	154182201	+	Silent	SNP	C	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:154182201C>T	uc004fmt.2	-	12	2040	c.1869G>A	c.(1867-1869)GAG>GAA	p.E623E		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	623	F5/8 type A 2.|Plastocyanin-like 4.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ACTCTGGATCCTCAAGCTGCA	0.438													82	9					0	0	0.000781405	0	0
ESPN	83715	broad.mit.edu	37	1	6500831	6500831	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:6500831delC	uc001amy.2	+	4	989	c.821delC	c.(820-822)ACCfs	p.T274fs		NM_031475	NP_113663	B1AK53	ESPN_HUMAN	espin	274	ANK 9.				sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding				0	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		TGGGGCGGGACCCCGCTGCAC	0.612													2	4	---	---	---	---					
DNAJC11	55735	broad.mit.edu	37	1	6727803	6727804	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:6727803_6727804delTC	uc001aof.2	-	4	449_450	c.343_344delGA	c.(343-345)GAAfs	p.E115fs	DNAJC11_uc010nzt.1_Frame_Shift_Del_p.E77fs|DNAJC11_uc001aog.2_Frame_Shift_Del_p.E115fs|DNAJC11_uc010nzu.1_Frame_Shift_Del_p.E25fs	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	115					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCTCTCTTCTCTCTCTCTC	0.505													7	61	---	---	---	---					
BEST4	266675	broad.mit.edu	37	1	45249992	45249992	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:45249992delG	uc001cmm.2	-	9	1361	c.1312delC	c.(1312-1314)CGCfs	p.R438fs		NM_153274	NP_695006	Q8NFU0	BEST4_HUMAN	bestrophin 4	438	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	chloride channel activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGCGGGGGGCGGGGGGTGCCT	0.776													2	4	---	---	---	---					
CCDC18	343099	broad.mit.edu	37	1	93683360	93683371	+	In_Frame_Del	DEL	AGCCTTTGAAAA	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:93683360_93683371delAGCCTTTGAAAA	uc001dpq.2	+	14	2418_2429	c.2250_2261delAGCCTTTGAAAA	c.(2248-2262)TTAGCCTTTGAAAAA>TTA	p.AFEK751del	CCDC18_uc009wdl.1_Intron	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	sarcoma antigen NY-SAR-41	632_635	Potential.									ovary(2)|breast(2)|pancreas(1)	5		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAATTTGTTTAGCCTTTGAAAAAGCAAAGAAA	0.288													11	124	---	---	---	---					
MIA3	375056	broad.mit.edu	37	1	222837459	222837459	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr1:222837459delT	uc001hnl.2	+	27	5391	c.5382delT	c.(5380-5382)CCTfs	p.P1794fs	MIA3_uc001hnm.2_Frame_Shift_Del_p.P672fs	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1794	Pro-rich.|Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		TCTGCGGACCTTTTGGGCCTC	0.537													7	649	---	---	---	---					
PDZD7	79955	broad.mit.edu	37	10	102778804	102778804	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr10:102778804delC	uc001kso.1	-	8	1314	c.1099delG	c.(1099-1101)GACfs	p.D367fs	PDZD7_uc001ksn.2_Frame_Shift_Del_p.D367fs	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	PDZ domain containing 7	367						cilium|nucleus	protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		ATGGCTGTGTCCGCCCGCCCC	0.736											OREG0020453	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
KRTAP5-6	440023	broad.mit.edu	37	11	1718543	1718557	+	In_Frame_Del	DEL	GCTGTGGGTCCAGCT	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr11:1718543_1718557delGCTGTGGGTCCAGCT	uc001lua.2	+	1	119_133	c.68_82delGCTGTGGGTCCAGCT	c.(67-84)GGCTGTGGGTCCAGCTGC>GGC	p.CGSSC24del		NM_001012416	NP_001012416	Q6L8G9	KRA56_HUMAN	keratin associated protein 5-6	24_28	1.|6 X 4 AA repeats of C-C-X-P.					keratin filament					0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGCTGTGGGGGCTGTGGGTCCAGCTGCTGTGTGCC	0.656													24	59	---	---	---	---					
CCNT1	904	broad.mit.edu	37	12	49087434	49087436	+	In_Frame_Del	DEL	ATG	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr12:49087434_49087436delATG	uc001rse.1	-	9	1884_1886	c.1561_1563delCAT	c.(1561-1563)CATdel	p.H521del	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_In_Frame_Del_p.H236del	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	521	His-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						AGTGGTGATTATGATGATGATGA	0.443													7	485	---	---	---	---					
SACS	26278	broad.mit.edu	37	13	23908923	23908941	+	Frame_Shift_Del	DEL	AGTAAATTGTCAAAAAATG	-	-	rs144616826		TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:23908923_23908941delAGTAAATTGTCAAAAAATG	uc001uon.2	-	10	9663_9681	c.9074_9092delCATTTTTTGACAATTTACT	c.(9073-9093)CCATTTTTTGACAATTTACTAfs	p.P3025fs	SACS_uc001uoo.2_Frame_Shift_Del_p.P2878fs|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	3025_3031					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTCATCCTGTAGTAAATTGTCAAAAAATGGTCTAGTTTT	0.352													14	61	---	---	---	---					
HSPH1	10808	broad.mit.edu	37	13	31715381	31715382	+	Frame_Shift_Ins	INS	-	T	T			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:31715381_31715382insT	uc001utj.2	-	13	2129_2130	c.1731_1732insA	c.(1729-1734)AAAGTTfs	p.K577fs	HSPH1_uc001utk.2_Frame_Shift_Ins_p.K533fs|HSPH1_uc010aaw.2_Frame_Shift_Ins_p.K536fs|HSPH1_uc001utl.2_Frame_Shift_Ins_p.K579fs|HSPH1_uc010tds.1_Frame_Shift_Ins_p.K501fs	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	577_578					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		GGCTGGTCAACTTTTTTTTCAT	0.376													7	118	---	---	---	---					
C13orf1	57213	broad.mit.edu	37	13	50502187	50502187	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr13:50502187delA	uc001vdl.2	-	3	520	c.258delT	c.(256-258)GTTfs	p.V86fs	C13orf1_uc001vdm.2_Frame_Shift_Del_p.V47fs|C13orf1_uc010tgm.1_Intron|C13orf1_uc010adj.2_Frame_Shift_Del_p.V86fs	NM_020456	NP_065189	Q5W111	SPRY7_HUMAN	chromosome 13 open reading frame 1 isoform 1	86	B30.2/SPRY.										0		Lung NSC(96;7.5e-06)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Acute lymphoblastic leukemia(7;0.117)		GBM - Glioblastoma multiforme(99;1.72e-10)|COAD - Colon adenocarcinoma(199;0.208)		GATTCAAGTTAACCTTCTGAG	0.393													10	43	---	---	---	---					
TCL6	27004	broad.mit.edu	37	14	96129844	96129844	+	Frame_Shift_Del	DEL	C	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr14:96129844delC	uc001yeq.2	+	4	1532	c.63delC	c.(61-63)TGCfs	p.C21fs	TCL6_uc001yep.1_RNA|TCL6_uc001yes.2_5'UTR|TCL6_uc001yet.1_5'UTR|TCL6_uc001yeu.2_5'UTR|TCL6_uc001yev.2_5'UTR|TCL1B_uc001yew.2_RNA|TCL1B_uc001yex.2_RNA|TCL1B_uc010avj.2_RNA	NM_020554	NP_065579			SubName: Full=T-cell leukemia/lymphoma 6 ORF163;												0		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		aggtttcctgccccagtgctc	0.144			T	TRA@	T-ALL								8	17	---	---	---	---					
DHX8	1659	broad.mit.edu	37	17	41584910	41584915	+	In_Frame_Del	DEL	GAAACA	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr17:41584910_41584915delGAAACA	uc002idu.1	+	14	2036_2041	c.1963_1968delGAAACA	c.(1963-1968)GAAACAdel	p.ET655del	DHX8_uc010wif.1_In_Frame_Del_p.ET564del|DHX8_uc010wig.1_In_Frame_Del_p.ET655del	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	655_656	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		CACTAGCCCTGAAACAGTCATCAAGT	0.476													18	18	---	---	---	---					
LPIN2	9663	broad.mit.edu	37	18	2939491	2939495	+	Frame_Shift_Del	DEL	GGGAA	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr18:2939491_2939495delGGGAA	uc002klo.2	-	6	1044_1048	c.805_809delTTCCC	c.(805-810)TTCCCAfs	p.F269fs		NM_014646	NP_055461	Q92539	LPIN2_HUMAN	lipin 2	269_270					fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity			ovary(1)|skin(1)	2				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		GGTGGACTCTGGGAATCCGCCCCAC	0.502													32	13	---	---	---	---					
SBK2	646643	broad.mit.edu	37	19	56041414	56041415	+	Frame_Shift_Del	DEL	CC	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr19:56041414_56041415delCC	uc010ygc.1	-	3	732_733	c.732_733delGG	c.(730-735)CTGGACfs	p.L244fs		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	SH3-binding domain kinase family, member 2	244_245	Protein kinase.						ATP binding|protein serine/threonine kinase activity				0						GCCCAGGCGTCCAGGGCGGGCT	0.752													2	4	---	---	---	---					
INSM1	3642	broad.mit.edu	37	20	20350010	20350010	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:20350010delT	uc002wrx.2	+	1	1246	c.1099delT	c.(1099-1101)TACfs	p.Y367fs		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	367	C2H2-type 3.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		GGACGGGCTCTACGAGTGCCA	0.741													7	4	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29628229	29628230	+	Frame_Shift_Ins	INS	-	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr20:29628229_29628230insA	uc010ztl.1	+	3	173_174	c.141_142insA	c.(139-144)GGGAAAfs	p.G47fs	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_5'UTR					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TCACTTAGGGGAAAATGGCTTT	0.322													9	97	---	---	---	---					
POLQ	10721	broad.mit.edu	37	3	121207488	121207489	+	Frame_Shift_Ins	INS	-	A	A			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr3:121207488_121207489insA	uc003eee.3	-	16	4418_4419	c.4289_4290insT	c.(4288-4290)TTAfs	p.L1430fs	POLQ_uc003eed.2_Frame_Shift_Ins_p.L602fs	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1430					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CATTCTTTTTTAAAAAAAGACC	0.342								DNA_polymerases_(catalytic_subunits)					8	51	---	---	---	---					
SPOCK1	6695	broad.mit.edu	37	5	136448181	136448181	+	Frame_Shift_Del	DEL	A	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr5:136448181delA	uc003lbo.2	-	4	608	c.417delT	c.(415-417)TGTfs	p.C139fs	SPOCK1_uc003lbp.2_Frame_Shift_Del_p.C139fs	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	139	Kazal-like.				cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTGCCACGGGACAGGGCTTGC	0.458													19	45	---	---	---	---					
CDKN2A	1029	broad.mit.edu	37	9	21974715	21974732	+	In_Frame_Del	DEL	GCAGCGCCCCCGCCTCCA	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chr9:21974715_21974732delGCAGCGCCCCCGCCTCCA	uc003zpk.2	-	1	307_324	c.95_112delTGGAGGCGGGGGCGCTGC	c.(94-114)CTGGAGGCGGGGGCGCTGCCC>CCC	p.LEAGAL32del	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_In_Frame_Del_p.LEAGAL32del|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	32_37	ANK 1.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.L32_L37del(6)|p.G35E(3)|p.L37L(2)|p.A34V(2)|p.V28_E33del(2)|p.R29_A34del(2)|p.G35R(2)|p.A36T(1)|p.E33D(1)|p.A34A(1)|p.E33fs*8(1)|p.L37fs*6(1)|p.R29fs*9(1)|p.A36fs*8(1)|p.L32R(1)|p.G35fs*13(1)|p.E33*(1)|p.V28_V51del(1)|p.P38fs*7(1)|p.G35V(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GGTGCGTTGGGCAGCGCCCCCGCCTCCAGCAGCGCCCG	0.711		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			90	74	---	---	---	---					
NUDT11	55190	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	-	-			TCGA-EE-A3AG-06A-31D-A196-08	TCGA-EE-A3AG-10A-01D-A198-08									Somatic	Phase_I	Capture				Illumina GAIIx	0687b673-2aff-4c35-8bf6-db58424fd301	1f4737a1-4b81-4037-8c7a-a57c4b80b7ed	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	uc010njt.2	-	1						NM_018159	NP_060629	Q96G61	NUD11_HUMAN	nudix-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.584										HNSCC(48;0.14)			3	5	---	---	---	---					
