Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MMEL1	79258	broad.mit.edu	37	1	2522449	2522449	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:2522449C>T	uc001ajy.2	-	24	2534	c.2320G>A	c.(2320-2322)GAG>AAG	p.E774K	C1orf93_uc001aju.1_3'UTR|C1orf93_uc001ajw.1_3'UTR|C1orf93_uc001ajv.1_3'UTR|C1orf93_uc010nzd.1_3'UTR|C1orf93_uc010nze.1_3'UTR|C1orf93_uc010nzf.1_3'UTR|C1orf93_uc001ajx.1_3'UTR|MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	774	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CGGCATCGCTCCTTGGGGTGC	0.701													7	13					0	0	0.004482	0	0
PTCHD2	57540	broad.mit.edu	37	1	11562836	11562836	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:11562836C>T	uc001ash.3	+	3	1336	c.1198C>T	c.(1198-1200)CTG>TTG	p.L400L	PTCHD2_uc001asi.1_Silent_p.L400L	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	400	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CAGTGAGATCCTGTTTGGAGC	0.562													17	26					0	0	0.004007	0	0
RCC1	1104	broad.mit.edu	37	1	28858821	28858821	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:28858821C>T	uc001bqg.1	+	4	485	c.400C>T	c.(400-402)CTC>TTC	p.L134F	SNHG3-RCC1_uc001bqa.1_Missense_Mutation_p.L134F|SNHG3-RCC1_uc001bqb.1_Missense_Mutation_p.L134F|SNHG3-RCC1_uc001bqc.1_Missense_Mutation_p.L134F|RCC1_uc001bqe.1_Missense_Mutation_p.L151F|RCC1_uc001bqf.1_Missense_Mutation_p.L165F	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	134	RCC1 2.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		CACAGCAGCCCTCACCGATGA	0.577													10	32					0	0	0.008291	0	0
PHC2	1912	broad.mit.edu	37	1	33840973	33840973	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:33840973G>A	uc001bxg.1	-	1	222	c.168C>T	c.(166-168)ACC>ACT	p.T56T	PHC2_uc001bxh.1_Silent_p.T56T|PHC2_uc009vuh.1_Silent_p.T56T|PHC2_uc001bxi.1_Silent_p.T56T	NM_198040	NP_932157	Q8IXK0	PHC2_HUMAN	polyhomeotic-like 2 isoform a	56	Gln-rich.				multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TTACCTGCACGGTCTGCCGGT	0.383													39	50					0	0	0.002522	0	0
CSMD2	114784	broad.mit.edu	37	1	34037281	34037281	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:34037281C>T	uc001bxn.1	-	52	7843	c.7814G>A	c.(7813-7815)CGA>CAA	p.R2605Q	CSMD2_uc001bxm.1_Missense_Mutation_p.R2603Q	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2605	Sushi 16.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AAGCCTCCATCGGCCATGCTC	0.483													27	33					0	0	0.008361	0	0
EIF2C1	26523	broad.mit.edu	37	1	36367133	36367133	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:36367133C>T	uc001bzl.2	+	9	1292	c.1079C>T	c.(1078-1080)TCG>TTG	p.S360L	EIF2C1_uc001bzk.2_Missense_Mutation_p.S285L|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	360					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AACCAGACCTCGACCATGATA	0.527													24	50					0	0	0.002299	0	0
GRIK3	2899	broad.mit.edu	37	1	37282688	37282688	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:37282688C>T	uc001caz.2	-	13	2199	c.2064G>A	c.(2062-2064)AAG>AAA	p.K688K	GRIK3_uc001cba.1_Silent_p.K688K	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	688	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGGCCCCATCCTTGACAGCCC	0.557													14	28					0	0	0.003163	0	0
C8B	732	broad.mit.edu	37	1	57420480	57420480	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:57420480G>A	uc001cyp.2	-	4	479	c.412C>T	c.(412-414)CTT>TTT	p.L138F	C8B_uc010oon.1_Missense_Mutation_p.L76F|C8B_uc010ooo.1_Missense_Mutation_p.L86F	NM_000066	NP_000057	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	138	LDL-receptor class A.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				central_nervous_system(2)|large_intestine(1)|ovary(1)	4						TTGCAAAGAAGTCTGCGGTTT	0.428													18	54					0	0	0.008871	0	0
LRRC7	57554	broad.mit.edu	37	1	70541893	70541893	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:70541893C>T	uc001dep.2	+	22	4280	c.4250C>T	c.(4249-4251)CCC>CTC	p.P1417L	LRRC7_uc009wbg.2_Missense_Mutation_p.P701L|LRRC7_uc001deq.2_Missense_Mutation_p.P611L	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1417						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						ATTCAGATCCCCTCTTCACAG	0.502													35	46					0	0	0.004878	0	0
C1orf173	127254	broad.mit.edu	37	1	75055424	75055424	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:75055424C>T	uc001dgg.2	-	12	2286	c.2067G>A	c.(2065-2067)GGG>GGA	p.G689G	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.G483G	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	689	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AAACATGTTTCCCGGACTTCT	0.458													39	87					0	0	0.005524	0	0
SLC44A5	204962	broad.mit.edu	37	1	75707705	75707705	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:75707705C>T	uc001dgu.2	-	9	657	c.513G>A	c.(511-513)GCG>GCA	p.A171A	SLC44A5_uc001dgt.2_Silent_p.A171A|SLC44A5_uc001dgs.2_Silent_p.A129A|SLC44A5_uc001dgr.2_Silent_p.A129A|SLC44A5_uc010oqz.1_Silent_p.A210A|SLC44A5_uc010ora.1_Silent_p.A165A|SLC44A5_uc010orb.1_Silent_p.A41A	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	171	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TGGGAAAAATCGCTGTTGGAC	0.313													16	46					0	0	0.006122	0	0
ACADM	34	broad.mit.edu	37	1	76226820	76226820	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:76226820C>T	uc001dgw.3	+	11	1389	c.959C>T	c.(958-960)TCA>TTA	p.S320L	ACADM_uc010ord.1_Missense_Mutation_p.S234L|ACADM_uc009wbp.2_Missense_Mutation_p.S324L|ACADM_uc009wbr.2_Missense_Mutation_p.S353L|ACADM_uc010ore.1_Missense_Mutation_p.S284L|ACADM_uc010orf.1_Missense_Mutation_p.S131L|ACADM_uc001dgx.3_Missense_Mutation_p.S234L|ACADM_uc010org.1_Missense_Mutation_p.S190L|ACADM_uc009wbs.1_RNA	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	320					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						CAAGCAATATCATTTATGCTG	0.318													12	15					0	0	0.000978	0	0
CTBS	1486	broad.mit.edu	37	1	85035652	85035652	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:85035652T>A	uc001dka.2	-	3	552	c.487A>T	c.(487-489)ACT>TCT	p.T163S	CTBS_uc001dkc.2_Missense_Mutation_p.T72S|CTBS_uc001dkd.2_Intron|CTBS_uc001dkb.2_Intron	NM_004388	NP_004379	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl- precursor	163						lysosome	cation binding				0				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		GAGTCTGTAGTTTCTTTGACT	0.323													20	39					0	0	0.003954	0	0
COL24A1	255631	broad.mit.edu	37	1	86375686	86375686	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:86375686C>T	uc001dlj.2	-	26	2659	c.2617G>A	c.(2617-2619)GGA>AGA	p.G873R	COL24A1_uc001dli.2_Missense_Mutation_p.G9R|COL24A1_uc010osd.1_Missense_Mutation_p.G173R|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	873	Collagen-like 6.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CCACGTTCTCCCTTTTAAGAG	0.383													49	110					0	0	0.003610	0	0
COL24A1	255631	broad.mit.edu	37	1	86581030	86581030	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:86581030G>A	uc001dlj.2	-	4	1565	c.1523C>T	c.(1522-1524)CCG>CTG	p.P508L	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.P508L	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	508	Collagen-like 1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTTCCCTGACGGACCTGGGAT	0.423													10	27					0	0	0.001368	0	0
HIPK1	204851	broad.mit.edu	37	1	114483987	114483987	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:114483987C>T	uc001eem.2	+	2	1143	c.982C>T	c.(982-984)CGC>TGC	p.R328C	HIPK1_uc001eel.2_Missense_Mutation_p.R328C|HIPK1_uc001een.2_Missense_Mutation_p.R328C	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	328	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGATCCAGTTCGCCAGCCCTA	0.493													49	213					0	0	0.003610	0	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	T	T	rs121913254		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:115256530G>T	uc009wgu.2	-	3	435	c.181C>A	c.(181-183)CAA>AAA	p.Q61K		NM_002524	NP_002515	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61	GTP.		Q -> K (in neuroblastoma cell).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(757)|p.Q61K(537)|p.Q61L(147)|p.Q61H(95)|p.Q61P(21)|p.Q61E(9)|p.Q61?(4)|p.Q61Q(3)|p.Q61_E62>HK(1)		haematopoietic_and_lymphoid_tissue(1008)|skin(956)|thyroid(334)|large_intestine(62)|NS(60)|soft_tissue(32)|lung(31)|upper_aerodigestive_tract(25)|urinary_tract(12)|liver(10)|adrenal_gland(9)|autonomic_ganglia(8)|testis(8)|central_nervous_system(8)|prostate(8)|breast(7)|biliary_tract(6)|ovary(6)|stomach(5)|pancreas(5)|endometrium(2)|kidney(2)|cervix(2)|eye(1)	2607	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458	Q61K(HT1080_SOFT_TISSUE)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(TYKNU_OVARY)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH2087_LUNG)|Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HS944T_SKIN)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(HS936T_SKIN)|Q61K(NCIH1299_LUNG)	50	Mis		melanoma|MM|AML|thyroid				Noonan_syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			238	75					1.38977e-115	2.13398e-115	0.003610	1	0
SPAG17	200162	broad.mit.edu	37	1	118523996	118523996	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:118523996C>T	uc001ehk.2	-	43	5969	c.5901G>A	c.(5899-5901)CAG>CAA	p.Q1967Q		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1967						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTGAGGATTTCTGTTCTGAAA	0.338													14	98					0	0	0.004990	0	0
SPAG17	200162	broad.mit.edu	37	1	118550790	118550790	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:118550790C>T	uc001ehk.2	-	31	4532	c.4464G>A	c.(4462-4464)GTG>GTA	p.V1488V		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1488						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GCATACACTTCACCTGCCTGG	0.493													11	71					0	0	0.001855	0	0
ADAM30	11085	broad.mit.edu	37	1	120438723	120438723	+	Silent	SNP	G	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:120438723G>T	uc001eij.2	-	1	391	c.237C>A	c.(235-237)CCC>CCA	p.P79P		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	79					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GAAGTCTCTTGGGCCACAAAT	0.532													10	915					0.00448238	0.00671682	0.004482	1	0
C1orf51	148523	broad.mit.edu	37	1	150259002	150259002	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:150259002C>T	uc001euh.2	+	6	930	c.794C>T	c.(793-795)CCA>CTA	p.P265L	C1orf51_uc001eui.2_Missense_Mutation_p.P177L|C1orf51_uc001euj.2_Missense_Mutation_p.P265L	NM_144697	NP_653298	Q8N365	CA051_HUMAN	hypothetical protein LOC148523	265											0	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CACACCACTCCAATTTGCAAC	0.517													23	108					0	0	0.003330	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058665	152058665	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:152058665C>T	uc001ezo.1	-	3	1558	c.1493G>A	c.(1492-1494)AGA>AAA	p.R498K		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	498							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ATCTTGTGTTCTTTCTCTTGC	0.483													208	94					0	0	0.003610	0	0
IL6R	3570	broad.mit.edu	37	1	154408531	154408531	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:154408531C>T	uc001fez.1	+	6	1331	c.894C>T	c.(892-894)TTC>TTT	p.F298F	IL6R_uc001ffa.1_Silent_p.F298F	NM_000565	NP_000556	P08887	IL6RA_HUMAN	interleukin 6 receptor isoform 1 precursor	298	Fibronectin type-III.|Extracellular (Potential).				acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity			ovary(3)|breast(1)	4	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGGAGGAGTTCGGGCAAGGCG	0.642													18	91					0	0	0.008871	0	0
TRIM46	80128	broad.mit.edu	37	1	155149757	155149757	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:155149757G>A	uc001fhs.1	+	5	983	c.900G>A	c.(898-900)AGG>AGA	p.R300R	RAG1AP1_uc010pey.1_Intron|TRIM46_uc009wpe.1_RNA|TRIM46_uc010pez.1_Silent_p.R287R|TRIM46_uc001fhq.2_RNA|TRIM46_uc001fhr.2_Silent_p.R300R|TRIM46_uc001fht.1_RNA|TRIM46_uc010pfa.1_Silent_p.R174R|TRIM46_uc001fhu.1_Silent_p.R277R|TRIM46_uc009wpg.1_Silent_p.R287R|TRIM46_uc001fhv.3_Silent_p.R287R|TRIM46_uc001fhw.1_RNA	NM_025058	NP_079334	Q7Z4K8	TRI46_HUMAN	tripartite motif-containing 46	300						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;6.62e-10)|all cancers(21;2.68e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGGCCGTGAGGCACACCGAGG	0.602													70	33					0	0	0.003610	0	0
FCRL3	115352	broad.mit.edu	37	1	157665255	157665255	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:157665255C>T	uc001frb.2	-	8	1567	c.1275G>A	c.(1273-1275)GGG>GGA	p.G425G	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.G425G|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.G151G|FCRL3_uc001frc.1_Silent_p.G425G	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	425	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CTGAGCTGTTCCCCAGGGTGA	0.577													33	153					0	0	0.003755	0	0
OR10X1	128367	broad.mit.edu	37	1	158548760	158548760	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:158548760C>T	uc010pin.1	-	1	930	c.930G>A	c.(928-930)ATG>ATA	p.M310I		NM_001004477	NP_001004477	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AAGCATTTTTCATGTCCTTAT	0.438													68	101					0	0	0.003610	0	0
DARC	2532	broad.mit.edu	37	1	159176010	159176010	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:159176010G>A	uc001fto.2	+	2	1021	c.781G>A	c.(781-783)GGA>AGA	p.G261R	DARC_uc001ftp.3_Missense_Mutation_p.G263R	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	261	Helical; Name=6; (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					GGTGGTTCTAGGACTGGATTT	0.567													37	182					0	0	0.003755	0	0
FCER1A	2205	broad.mit.edu	37	1	159273949	159273949	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:159273949C>T	uc001ftq.2	+	4	407	c.308C>T	c.(307-309)CCT>CTT	p.P103L		NM_002001	NP_001992	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor	103	Extracellular (Potential).|Ig-like 1.					integral to plasma membrane				lung(2)|skin(2)|prostate(1)	5	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	GAGAGTGAACCTGTGTACCTG	0.393													15	65					0	0	0.004990	0	0
VSIG8	391123	broad.mit.edu	37	1	159828675	159828675	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:159828675C>T	uc001fuh.2	-	2	213	c.77G>A	c.(76-78)GGG>GAG	p.G26E		NM_001013661	NP_001013683	Q5VU13	VSIG8_HUMAN	V-set and immunoglobulin domain containing 8	26	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane				central_nervous_system(1)	1	all_hematologic(112;0.0597)					CTGTCCATCCCCGTTGATCCG	0.602													47	32					0	0	0.003610	0	0
KCNJ9	3765	broad.mit.edu	37	1	160054431	160054431	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:160054431C>T	uc001fuy.1	+	2	853	c.611C>T	c.(610-612)TCC>TTC	p.S204F		NM_004983	NP_004974	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel subfamily	204	Cytoplasmic (By similarity).				synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			ovary(1)|skin(1)	2	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGGAGGCCTCCATCCGCGCC	0.677													12	8					0	0	0.000978	0	0
ATP1A4	480	broad.mit.edu	37	1	160141494	160141494	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:160141494C>T	uc001fve.3	+	12	2280	c.1801C>T	c.(1801-1803)CCC>TCC	p.P601S	ATP1A4_uc001fvf.3_RNA|ATP1A4_uc001fvg.2_Missense_Mutation_p.P104S	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	601	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GATTGACCCTCCCCGAGCTGC	0.488													139	84					0	0	0.003610	0	0
PCP4L1	654790	broad.mit.edu	37	1	161254232	161254232	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:161254232C>T	uc001gad.2	+	3	416	c.168C>T	c.(166-168)TTC>TTT	p.F56F		NM_001102566	NP_001096036	A6NKN8	PC4L1_HUMAN	Purkinje cell protein 4 like 1	56	IQ.										0	all_cancers(52;4.16e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			AGGGCAAGTTCCGGCGATTTC	0.527													57	25					0	0	0.003610	0	0
GPA33	10223	broad.mit.edu	37	1	167032862	167032862	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:167032862C>T	uc001gea.1	-	4	872	c.528G>A	c.(526-528)AAG>AAA	p.K176K		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	176	Ig-like C2-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0						TGTTGTACCTCTTCCAGCTGT	0.572													14	109					0	0	0.003163	0	0
DUSP27	92235	broad.mit.edu	37	1	167096059	167096059	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:167096059G>A	uc001geb.1	+	5	1691	c.1691G>A	c.(1690-1692)GGA>GAA	p.G564E		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	564					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						TTGGGAGCGGGAGACAGCAGC	0.547													64	33					0	0	0.003610	0	0
DUSP27	92235	broad.mit.edu	37	1	167097470	167097470	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:167097470G>A	uc001geb.1	+	5	3102	c.3102G>A	c.(3100-3102)GAG>GAA	p.E1034E		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1034	Ser-rich.				protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GTTCCCGAGAGGAGAGCCCAG	0.577													33	21					0	0	0.003271	0	0
FMO3	2328	broad.mit.edu	37	1	171076868	171076868	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:171076868G>A	uc001ghi.2	+	4	485	c.374G>A	c.(373-375)TGG>TAG	p.W125*	FMO3_uc001ghh.2_Nonsense_Mutation_p.W125*|FMO3_uc010pmb.1_Nonsense_Mutation_p.W105*|FMO3_uc010pmc.1_Nonsense_Mutation_p.W62*	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	125					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACTGGCCAGTGGGATGTTACC	0.398													15	50					0	0	0.004007	0	0
FMO4	2329	broad.mit.edu	37	1	171310800	171310800	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:171310800G>A	uc001gho.2	+	10	1716	c.1499G>A	c.(1498-1500)CGA>CAA	p.R500Q		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	500					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TTAAAAACTCGAATTGTCCCT	0.478													22	24					0	0	0.001882	0	0
MIR488	574441	broad.mit.edu	37	1	176998572	176998572	+	RNA	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:176998572G>A	hsa-mir-488|MI0003123	-			c.10G>A			ASTN1_uc001glb.1_Intron|ASTN1_uc001glc.2_Intron|ASTN1_uc001gld.1_Intron|ASTN1_uc009wwx.1_Intron|ASTN1_uc001gle.3_Intron																	0						ATCTGGGAGAGATGATTCTCT	0.398													11	6					0	0	0.000978	0	0
RASAL2	9462	broad.mit.edu	37	1	178411966	178411966	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:178411966G>A	uc001glr.2	+	6	765	c.640G>A	c.(640-642)GAA>AAA	p.E214K	RASAL2_uc001glq.2_Missense_Mutation_p.E362K	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	214	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						TTTCTGGGGCGAACATTTTGA	0.383													23	81					0	0	0.003330	0	0
LAMC2	3918	broad.mit.edu	37	1	183155552	183155552	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:183155552C>T	uc001gqa.2	+	1	379	c.65C>T	c.(64-66)ACC>ATC	p.T22I	LAMC2_uc001gpz.3_Missense_Mutation_p.T22I|LAMC2_uc010poa.1_5'UTR	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	22					cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						GCCCGGGCCACCTCCAGGAGG	0.657													6	58					0	0	0.001984	0	0
HMCN1	83872	broad.mit.edu	37	1	186088327	186088327	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:186088327A>G	uc001grq.1	+	78	12082	c.11853A>G	c.(11851-11853)GCA>GCG	p.A3951A		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3951	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTTTAGGAGCAATTGAAATAC	0.368													29	103					0	0	0.007291	0	0
KIF14	9928	broad.mit.edu	37	1	200559251	200559251	+	Splice_Site	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:200559251A>G	uc010ppk.1	-	17	3400	c.2961_splice	c.e17+1	p.L987_splice	KIF14_uc010ppj.1_Splice_Site_p.L496_splice	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14						microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TCTGCCTTTTACCAGTTCTGC	0.383													27	121					0	0	0.004656	0	0
ADORA1	134	broad.mit.edu	37	1	203134630	203134630	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:203134630C>T	uc001gze.1	+	4	1016	c.583C>T	c.(583-585)CTC>TTC	p.L195F	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.L195F|ADORA1_uc010pqg.1_Missense_Mutation_p.L127F|ADORA1_uc009xak.1_Missense_Mutation_p.P120L|ADORA1_uc010pqh.1_Missense_Mutation_p.L228F	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	195	Helical; Name=5; (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CCCGCTTCTCCTCATGGTCCT	0.552													19	113					0	0	0.001523	0	0
CHI3L1	1116	broad.mit.edu	37	1	203150327	203150327	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:203150327C>T	uc001gzi.2	-	7	845	c.674G>A	c.(673-675)GGT>GAT	p.G225D	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzk.1_Missense_Mutation_p.G22D|CHI3L1_uc001gzj.2_Missense_Mutation_p.G225D|CHI3L1_uc001gzl.3_5'Flank	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	225					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1						ATCCTCCTGACCTCGGAACAG	0.572													29	143					0	0	0.002096	0	0
SOX13	9580	broad.mit.edu	37	1	204091084	204091084	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:204091084G>A	uc001ham.2	+	8	1427	c.832G>A	c.(832-834)GGG>AGG	p.G278R	SOX13_uc010pqp.1_Missense_Mutation_p.G277R|SOX13_uc010pqq.1_Missense_Mutation_p.G145R	NM_005686	NP_005677	Q9UN79	SOX13_HUMAN	SRY-box 13	278	Pro-rich.				anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			GAAGAGGCCTGGGGCCATGGC	0.637													5	30					0	0	0.000602	0	0
NEK2	4751	broad.mit.edu	37	1	211840481	211840482	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:211840481_211840482CC>TT	uc001hir.1	-	7	1223_1224	c.1077_1078GG>AA	c.(1075-1080)AAGGAA>AAAAAA	p.E360K	NEK2_uc001hiq.1_Missense_Mutation_p.E360K|NEK2_uc001his.3_Missense_Mutation_p.E360K	NM_002497	NP_002488	P51955	NEK2_HUMAN	NIMA-related kinase 2	360	Necessary for interaction with MAD1L1.|Required for microtubule binding and for localization to the centrosomes.|Potential.|Interaction with PCNT.				cell division|centrosome separation|G2/M transition of mitotic cell cycle|meiosis|protein autophosphorylation|regulation of mitosis	centrosome|condensed chromosome kinetochore|cytosol|nucleolus	ATP binding|metal ion binding|protein binding|protein phosphatase binding|protein serine/threonine kinase activity			breast(2)|stomach(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.00203)|all cancers(67;0.0339)|Epithelial(68;0.0546)		AACTTCCGTTCCTTTAGCAAGC	0.431													77	48					0	0	0.004672	0	0
JMJD4	65094	broad.mit.edu	37	1	227921164	227921165	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:227921164_227921165CC>TT	uc001hrb.2	-	4	910_911	c.910_911GG>AA	c.(910-912)GGC>AAC	p.G304N	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|LOC100130093_uc001hqx.3_RNA|LOC100130093_uc001hqy.3_RNA|JMJD4_uc001hrc.2_Missense_Mutation_p.G304N	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	304	JmjC.										0		Prostate(94;0.0885)				CACCATCTCGCCCGCTTCCTGC	0.624													31	24					0	0	0.004672	0	0
NUP133	55746	broad.mit.edu	37	1	229606385	229606385	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:229606385T>C	uc001htn.2	-	15	2110	c.2018A>G	c.(2017-2019)AAC>AGC	p.N673S		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	673					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CTCCCTCTTGTTCAAAGCAAT	0.483													77	36					0	0	0.003610	0	0
TRIM67	440730	broad.mit.edu	37	1	231335968	231335968	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:231335968G>A	uc009xfn.1	+	4	1380	c.1338G>A	c.(1336-1338)GAG>GAA	p.E446E		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	tripartite motif-containing 67	446						cytoplasm|cytoskeleton	zinc ion binding			ovary(2)|breast(1)|kidney(1)	4	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				ACTGCCTGGAGGTGATCAAGG	0.527													97	71					0	0	0.003610	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232650407	232650407	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:232650407G>A	uc001hvg.2	-	1	837	c.679C>T	c.(679-681)CCT>TCT	p.P227S		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	227					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AACCCAAAAGGGACCATTGCT	0.468													32	155					0	0	0.001786	0	0
AKT3	10000	broad.mit.edu	37	1	243716030	243716030	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:243716030C>T	uc001iab.1	-	10	1244	c.1163_splice	c.e10+1	p.R388_splice	AKT3_uc001hzz.1_Splice_Site_p.R388_splice	NM_005465	NP_005456	Q9Y243	AKT3_HUMAN	AKT3 kinase isoform 1						signal transduction	Golgi apparatus|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_cancers(71;0.000307)|all_epithelial(71;0.000374)|all_lung(81;0.0323)|Ovarian(71;0.0619)|all_neural(11;0.101)|Lung NSC(105;0.168)	all_cancers(173;0.0274)	all cancers(7;4.3e-08)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00196)			TTGAGGCTTACCGTTTATTTG	0.308													14	55					0	0	0.002450	0	0
NET1	10276	broad.mit.edu	37	10	5498571	5498571	+	Missense_Mutation	SNP	C	T	T	rs150542987		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:5498571C>T	uc001iia.2	+	12	1543	c.1405C>T	c.(1405-1407)CGC>TGC	p.R469C	NET1_uc010qar.1_Missense_Mutation_p.R288C|NET1_uc001iib.2_Missense_Mutation_p.R415C|NET1_uc010qas.1_Missense_Mutation_p.R288C	NM_001047160	NP_001040625	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming gene 1 isoform	469	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(1)	1						CTTTAGAATTCGCTTCCATGA	0.403													55	20					0	0	0.003610	0	0
NEBL	10529	broad.mit.edu	37	10	21097567	21097567	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:21097567C>T	uc001iqi.2	-	26	3030	c.2633G>A	c.(2632-2634)CGA>CAA	p.R878Q	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	878	Linker.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						AGACCAGTGTCGCCTATAGTG	0.413													51	31					0	0	0.003610	0	0
NEBL	10529	broad.mit.edu	37	10	21120485	21120485	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:21120485C>T	uc001iqi.2	-	15	1874	c.1477G>A	c.(1477-1479)GAA>AAA	p.E493K	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron|NEBL_uc001iql.1_RNA	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	493	Nebulin 13.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CCTTTAATTTCAGTCTCCAGA	0.423													28	10					0	0	0.007291	0	0
KIAA1217	56243	broad.mit.edu	37	10	24831852	24831852	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:24831852G>A	uc001iru.3	+	19	4056	c.3653G>A	c.(3652-3654)TGG>TAG	p.W1218*	KIAA1217_uc001irs.2_Intron|KIAA1217_uc001irt.3_Intron|KIAA1217_uc010qcy.1_Intron|KIAA1217_uc010qcz.1_Intron|KIAA1217_uc001irw.2_Intron|KIAA1217_uc001irz.2_Intron|KIAA1217_uc001irx.2_Nonsense_Mutation_p.W901*|KIAA1217_uc001iry.2_Intron|KIAA1217_uc001isa.1_Nonsense_Mutation_p.W54*	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	1218					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						CCTCCTAAGTGGGAAAGAGGA	0.423													21	8					0	0	0.001523	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315473	30315473	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:30315473C>T	uc001iux.2	-	2	3663	c.3604G>A	c.(3604-3606)GAA>AAA	p.E1202K	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.E1064K|KIAA1462_uc009xle.1_Missense_Mutation_p.E1202K	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1202										ovary(4)	4						TCCTTTTGTTCGAAGAACTTG	0.512													120	51					0	0	0.003610	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315749	30315749	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:30315749G>A	uc001iux.2	-	2	3387	c.3328C>T	c.(3328-3330)CAG>TAG	p.Q1110*	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Nonsense_Mutation_p.Q972*|KIAA1462_uc009xle.1_Nonsense_Mutation_p.Q1110*	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1110										ovary(4)	4						TCAGCAGGCTGGTTCTGTCCC	0.657													62	20					0	0	0.003610	0	0
DRGX	644168	broad.mit.edu	37	10	50594829	50594829	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:50594829C>T	uc010qgq.1	-	4	325	c.325G>A	c.(325-327)GAG>AAG	p.E109K		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	109					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCATGGGCTCCTTGGCTCCT	0.592													73	26					0	0	0.003610	0	0
ANK3	288	broad.mit.edu	37	10	61835611	61835611	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:61835611C>T	uc001jky.2	-	37	5220	c.5028G>A	c.(5026-5028)AAG>AAA	p.K1676K	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1676	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ACACCACTGACTTTAAAGGTG	0.413													42	14					0	0	0.003610	0	0
MYPN	84665	broad.mit.edu	37	10	69902729	69902729	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:69902729C>T	uc001jnm.3	+	4	1120	c.935C>T	c.(934-936)TCC>TTC	p.S312F	MYPN_uc001jnl.1_Missense_Mutation_p.S312F|MYPN_uc001jnn.3_Missense_Mutation_p.S37F|MYPN_uc001jno.3_Missense_Mutation_p.S312F|MYPN_uc001jnp.1_Missense_Mutation_p.S312F|MYPN_uc009xps.2_Missense_Mutation_p.S312F|MYPN_uc009xpt.2_Missense_Mutation_p.S312F|MYPN_uc010qit.1_Missense_Mutation_p.S18F|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	312	Interaction with CARP.|Ig-like 1.					nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						CTTGAAAATTCCCCAGATATT	0.468													40	13					0	0	0.008740	0	0
VPS26A	9559	broad.mit.edu	37	10	70925797	70925797	+	Splice_Site	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:70925797G>A	uc001jpb.2	+	7	785	c.659_splice	c.e7-1	p.G220_splice	VPS26A_uc001jpc.2_Splice_Site_p.G220_splice|VPS26A_uc009xqa.2_Splice_Site_p.G213_splice|VPS26A_uc001jpd.2_Splice_Site_p.G109_splice	NM_004896	NP_004887	O75436	VP26A_HUMAN	vacuolar protein sorting 26 A isoform 1						retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity				0						TATTGCACTAGGACCCAGTAC	0.289													17	11					0	0	0.008871	0	0
P4HA1	5033	broad.mit.edu	37	10	74813221	74813221	+	Silent	SNP	G	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:74813221G>C	uc010qka.1	-	7	925	c.591C>G	c.(589-591)GGC>GGG	p.G197G	P4HA1_uc001jtg.2_Silent_p.G197G|P4HA1_uc001jth.2_Silent_p.G197G|P4HA1_uc010qkb.1_Silent_p.G197G|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	197						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TAGAAATCTCGCCTTCATCCA	0.448													18	46					0	0	0.007413	0	0
ARHGAP19	84986	broad.mit.edu	37	10	99003878	99003878	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:99003878G>A	uc001knb.2	-	8	1061	c.1032C>T	c.(1030-1032)TCC>TCT	p.S344S	ARHGAP19_uc001kmy.2_RNA|ARHGAP19_uc001kna.2_Silent_p.S335S|ARHGAP19_uc009xvi.2_RNA|ARHGAP19_uc009xvj.2_Silent_p.S315S|ARHGAP19_uc009xvk.2_Silent_p.S138S	NM_032900	NP_116289	Q14CB8	RHG19_HUMAN	Rho GTPase activating protein 19	344					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	GTPase activator activity				0		Colorectal(252;0.0854)		Epithelial(162;7.65e-09)|all cancers(201;4.49e-07)		CCAGCTGAAAGGACTTAGTAT	0.448													21	43					0	0	0.002299	0	0
PKD2L1	9033	broad.mit.edu	37	10	102089771	102089771	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:102089771G>A	uc001kqx.1	-	1	473	c.90C>T	c.(88-90)TCC>TCT	p.S30S	PKD2L1_uc009xwm.1_5'UTR	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	30	Cytoplasmic (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		TCCCGTGTGGGGAAGGGGGAC	0.622													27	47					0	0	0.006320	0	0
PDCD11	22984	broad.mit.edu	37	10	105173056	105173056	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:105173056G>A	uc001kwy.1	+	9	1249	c.1162G>A	c.(1162-1164)GAT>AAT	p.D388N		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	388	S1 motif 4.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TAGGCTGAAGGATGGGGTTCT	0.547													25	7					0	0	0.004656	0	0
FGFR2	2263	broad.mit.edu	37	10	123276957	123276957	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:123276957C>T	uc010qtk.1	-	8	1607	c.960G>A	c.(958-960)ACG>ACA	p.T320T	FGFR2_uc010qtg.1_Intron|FGFR2_uc010qth.1_Silent_p.T205T|FGFR2_uc010qti.1_Silent_p.T231T|FGFR2_uc010qtj.1_Intron|FGFR2_uc010qtl.1_Intron|FGFR2_uc010qtm.1_Silent_p.T205T|FGFR2_uc001lfl.3_Intron|FGFR2_uc001lfm.2_Intron|FGFR2_uc001lfn.3_RNA|FGFR2_uc010qtn.1_Silent_p.T339T|FGFR2_uc010qto.1_Silent_p.T224T|FGFR2_uc001lfo.1_3'UTR|FGFR2_uc001lfg.3_5'UTR	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	320	Ig-like C2-type 3.|Extracellular (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TCTCTTTGTCCGTGGTGTTAA	0.478		5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				21	8					0	0	0.001882	0	0
KNDC1	85442	broad.mit.edu	37	10	134981777	134981777	+	Silent	SNP	C	T	T	rs79557483	byFrequency	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:134981777C>T	uc001llz.1	+	3	322	c.321C>T	c.(319-321)TTC>TTT	p.F107F	KNDC1_uc001lma.1_Silent_p.F42F	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	107	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGGGTGCCTTCGTTCCCCCCG	0.597													71	27					0	0	0.003610	0	0
LOC653544	653544	broad.mit.edu	37	10	135491107	135491107	+	Missense_Mutation	SNP	G	A	A	rs138808999	by1000genomes	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr10:135491107G>A	uc010qvi.1	+	1	829	c.718G>A	c.(718-720)GCC>ACC	p.A240T		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	240						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTCGTGGGTCGCCTTCGCCCA	0.771													5	34					0	0	0.001984	0	0
IFITM3	10410	broad.mit.edu	37	11	320606	320606	+	Missense_Mutation	SNP	G	T	T	rs149004156	by1000genomes	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:320606G>T	uc001lpa.2	-	1	309	c.208C>A	c.(208-210)CCC>ACC	p.P70T	uc001loz.2_Intron	NM_021034	NP_066362	Q01628	IFM3_HUMAN	interferon-induced transmembrane protein 3	70	Interaction with SPP1.|Helical; (Potential).				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane		p.P70T(1)		central_nervous_system(7)	7		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGCAGCAGGGGTTCATGAAG	0.632													6	94					3.86212e-05	5.84902e-05	0.008291	1	0
IRF7	3665	broad.mit.edu	37	11	613551	613551	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:613551G>A	uc001lqh.2	-	9	1262	c.892C>T	c.(892-894)CGC>TGC	p.R298C	IRF7_uc009ycb.2_Missense_Mutation_p.R192C|IRF7_uc010qwf.1_Missense_Mutation_p.R297C|IRF7_uc001lqf.2_Missense_Mutation_p.R5C|IRF7_uc010qwg.1_Missense_Mutation_p.R5C|IRF7_uc001lqg.2_Missense_Mutation_p.R311C|IRF7_uc001lqi.2_Missense_Mutation_p.R269C|IRF7_uc010qwh.1_Missense_Mutation_p.R5C	NM_001572	NP_001563	Q92985	IRF7_HUMAN	interferon regulatory factor 7 isoform a	298					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of interferon-alpha production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(49;1.69e-08)|all_epithelial(84;1.65e-05)|Breast(177;0.000231)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;7.68e-28)|Epithelial(43;7.44e-27)|OV - Ovarian serous cystadenocarcinoma(40;3.53e-21)|BRCA - Breast invasive adenocarcinoma(625;6.96e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCACCGTGCGGCCCTTGTAC	0.657													3	30					0	0	0.004672	0	0
BRSK2	9024	broad.mit.edu	37	11	1471927	1471927	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:1471927C>T	uc001lti.2	+	14	1784	c.1398C>T	c.(1396-1398)TCC>TCT	p.S466S	BRSK2_uc009ycv.1_Silent_p.S488S|BRSK2_uc001lth.1_Silent_p.S466S|BRSK2_uc001ltj.2_Silent_p.S466S|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Silent_p.S466S|BRSK2_uc001ltm.2_Silent_p.S512S|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA|BRSK2_uc009ycw.2_5'UTR	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	466	Pro-rich.				establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		CGCCCCCGTCCAGCCCCAGCG	0.692													4	23					0	0	0.000602	0	0
TRPM5	29850	broad.mit.edu	37	11	2443397	2443397	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:2443397C>T	uc001lwm.3	-	2	281	c.272G>A	c.(271-273)GGG>GAG	p.G91E	TRPM5_uc010qxl.1_Missense_Mutation_p.G91E|TRPM5_uc009ydn.2_Missense_Mutation_p.G91E	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	91	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CTTCACCAGCCCCTTGCGCAG	0.701													10	105					0	0	0.006214	0	0
OR52J3	119679	broad.mit.edu	37	11	5067811	5067811	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:5067811T>C	uc010qyv.1	+	1	56	c.56T>C	c.(55-57)ATC>ACC	p.I19T		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCATTGGAATCCCAGGTCTG	0.453													38	12					0	0	0.003610	0	0
OR51B5	282763	broad.mit.edu	37	11	5364610	5364610	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:5364610C>T	uc001map.1	-	1	145	c.145G>A	c.(145-147)GAA>AAA	p.E49K	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Missense_Mutation_p.E49K	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTGTGATCTTCCTTAATGAGA	0.498													23	31					0	0	0.002299	0	0
OR52L1	338751	broad.mit.edu	37	11	6007408	6007408	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:6007408G>A	uc001mcd.2	-	1	808	c.753C>T	c.(751-753)GCC>GCT	p.A251A		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	251	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTTAAGTCGGGCCTCACTCC	0.512													64	29					0	0	0.003610	0	0
SAA2	6289	broad.mit.edu	37	11	18269549	18269549	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:18269549G>A	uc001mnz.3	-	2	47	c.10C>T	c.(10-12)CTC>TTC	p.L4F	SAA2_uc009yhj.2_Missense_Mutation_p.L4F	NM_030754	NP_110381	P02735	SAA_HUMAN	serum amyloid A2 isoform a	4					acute-phase response|elevation of cytosolic calcium ion concentration|innate immune response|lymphocyte chemotaxis|macrophage chemotaxis|negative regulation of inflammatory response|neutrophil chemotaxis|platelet activation|positive regulation of cell adhesion|positive regulation of interleukin-1 secretion	high-density lipoprotein particle	G-protein-coupled receptor binding				0					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	AGGCCCGTGAGAAGCTTCATG	0.512													4	47					0	0	0.000602	0	0
OR4A5	81318	broad.mit.edu	37	11	51411726	51411726	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:51411726T>A	uc001nhi.1	-	1	670	c.670A>T	c.(670-672)ACT>TCT	p.T224S		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	224	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				TGACTGTAAGTTTTAAGGGAG	0.418													38	12					0	0	0.002522	0	0
OR5L2	26338	broad.mit.edu	37	11	55595525	55595525	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:55595525C>T	uc001nhy.1	+	1	831	c.831C>T	c.(829-831)TTC>TTT	p.F277F		NM_001004739	NP_001004739	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_epithelial(135;0.208)				CCACCGTGTTCTACACAGTTG	0.468										HNSCC(27;0.073)			44	8					0	0	0.002522	0	0
OR5AN1	390195	broad.mit.edu	37	11	59132584	59132584	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:59132584C>T	uc010rks.1	+	1	653	c.653C>T	c.(652-654)TCC>TTC	p.S218F		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATCATGATATCCTATGGCTAT	0.423													67	25					0	0	0.003610	0	0
EEF1G	1937	broad.mit.edu	37	11	62327658	62327658	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:62327658G>A	uc001ntm.1	-	9	1184	c.1038C>T	c.(1036-1038)TTC>TTT	p.F346F	EEF1G_uc010rlw.1_Silent_p.F396F|EEF1G_uc001ntn.1_Silent_p.F226F	NM_001404	NP_001395	P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1	346	EF-1-gamma C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity				0						CCAGTCGCTGGAACATTCCTG	0.512													8	26					0	0	0.004482	0	0
RCOR2	283248	broad.mit.edu	37	11	63680420	63680420	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:63680420C>T	uc001nyc.2	-	9	1280	c.892_splice	c.e9-1	p.V298_splice		NM_173587	NP_775858	Q8IZ40	RCOR2_HUMAN	REST corepressor 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)|skin(1)	2						TGCTCTGTACCTGGGAAGGCC	0.582													22	7					0	0	0.002299	0	0
NRXN2	9379	broad.mit.edu	37	11	64419053	64419053	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:64419053G>A	uc001oar.2	-	15	3031	c.2592C>T	c.(2590-2592)ATC>ATT	p.I864I	NRXN2_uc001oas.2_Silent_p.I824I|NRXN2_uc001oaq.2_Silent_p.I531I	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GCTCCGTCATGATGCCCGTCT	0.587											OREG0021057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	30					0	0	0.000602	0	0
SYVN1	84447	broad.mit.edu	37	11	64900492	64900492	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:64900492G>A	uc001odb.2	-	4	373	c.279C>T	c.(277-279)ACC>ACT	p.T93T	SYVN1_uc001odc.2_Silent_p.T93T|SYVN1_uc009yqc.2_Silent_p.T93T	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	93	Cytoplasmic (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						CCCGAAAAACGGTGAAGGCCA	0.527													33	13					0	0	0.002836	0	0
SPTBN2	6712	broad.mit.edu	37	11	66475050	66475050	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:66475050G>A	uc001ojd.2	-	12	1662	c.1590C>T	c.(1588-1590)AAC>AAT	p.N530N		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	530					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCAGCTCCAGGTTGAGGAGGA	0.622													17	5					0	0	0.004007	0	0
PC	5091	broad.mit.edu	37	11	66638662	66638662	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:66638662G>A	uc001ojn.1	-	5	543	c.494C>T	c.(493-495)CCC>CTC	p.P165L	PC_uc001ojo.1_Missense_Mutation_p.P165L|PC_uc001ojp.1_Missense_Mutation_p.P165L	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	165	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AGGGACAACGGGAACACCTGT	0.632													35	16					0	0	0.003271	0	0
RSF1	51773	broad.mit.edu	37	11	77383160	77383160	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:77383160G>A	uc001oyn.2	-	15	3798	c.3678C>T	c.(3676-3678)TCC>TCT	p.S1226S	RSF1_uc001oym.2_Silent_p.S974S	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1226	Arg-rich.				CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AACTCTTCTGGGAACCGTCAC	0.413													12	158					0	0	0.001855	0	0
DLG2	1740	broad.mit.edu	37	11	83344290	83344290	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:83344290G>A	uc001paj.2	-	14	1892	c.1589C>T	c.(1588-1590)TCC>TTC	p.S530F	DLG2_uc001pai.2_Missense_Mutation_p.S427F|DLG2_uc010rsy.1_Missense_Mutation_p.S497F|DLG2_uc010rsz.1_Missense_Mutation_p.S530F|DLG2_uc010rta.1_Missense_Mutation_p.S530F|DLG2_uc001pak.2_Missense_Mutation_p.S635F|DLG2_uc010rtb.1_Missense_Mutation_p.S497F|DLG2_uc001pal.1_Missense_Mutation_p.S530F|DLG2_uc010rsw.1_Missense_Mutation_p.S12F|DLG2_uc010rsx.1_Missense_Mutation_p.S11F	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	530						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GGTTCGCAGGGATCCGGACCC	0.473													17	24					0	0	0.007413	0	0
FAT3	120114	broad.mit.edu	37	11	92507292	92507292	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:92507292C>T	uc001pdj.3	+	6	4298	c.4281C>T	c.(4279-4281)TCC>TCT	p.S1427S		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1427	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGCAGAGGTCCATCTATAATA	0.448										TCGA Ovarian(4;0.039)			101	206					0	0	0.003610	0	0
FAT3	120114	broad.mit.edu	37	11	92564905	92564905	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:92564905C>T	uc001pdj.3	+	13	9616	c.9599C>T	c.(9598-9600)TCG>TTG	p.S3200L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3200	Cadherin 29.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CAGCAGTCTTCGTACAACATC	0.562										TCGA Ovarian(4;0.039)			21	320					0	0	0.002780	0	0
ANKRD49	54851	broad.mit.edu	37	11	94231575	94231575	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:94231575C>T	uc001pew.2	+	3	736	c.597C>T	c.(595-597)TAC>TAT	p.Y199Y	ANKRD49_uc001pex.2_3'UTR|ANKRD49_uc001pey.2_RNA	NM_017704	NP_060174	Q8WVL7	ANR49_HUMAN	fetal globin inducing factor	199	ANK 4.				positive regulation of transcription, DNA-dependent					central_nervous_system(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TGAACCGTTACGTCAAACCAG	0.453													43	16					0	0	0.008740	0	0
CARD17	440068	broad.mit.edu	37	11	104971399	104971399	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:104971399C>T	uc001pir.1	-	2	132	c.115G>A	c.(115-117)GAG>AAG	p.E39K	CASP1_uc010rve.1_Intron|CASP1_uc010rvf.1_Intron|CASP1_uc010rvg.1_Intron|CASP1_uc010rvh.1_Intron|CASP1_uc010rvi.1_Intron	NM_001007232	NP_001007233	Q5XLA6	CAR17_HUMAN	caspase recruitment domain family, member 17	39	CARD.				proteolysis|regulation of apoptosis	cytoplasm	cysteine-type endopeptidase activity|cysteine-type endopeptidase inhibitor activity			ovary(1)	1						ATCTCTATCTCTTCCTGGCTC	0.448													8	100					0	0	0.003080	0	0
DRD2	1813	broad.mit.edu	37	11	113286293	113286293	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:113286293G>A	uc001pnz.2	-	4	894	c.573C>T	c.(571-573)GTC>GTT	p.V191V	DRD2_uc010rwv.1_Silent_p.V190V|DRD2_uc001poa.3_Silent_p.V191V|DRD2_uc001pob.3_Silent_p.V191V|DRD2_uc009yyr.1_Silent_p.V191V	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	191	Agonist binding (By similarity).|Helical; Name=5; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	TGGAGGAGTAGACCACGAAGG	0.597													8	18					0	0	0.003080	0	0
FAM55D	54827	broad.mit.edu	37	11	114442128	114442128	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:114442128C>T	uc001ppc.2	-	6	1348	c.1167G>A	c.(1165-1167)AGG>AGA	p.R389R	FAM55D_uc001ppd.2_Silent_p.R105R	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	389						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		TGTTGATGTTCCTATCCAAAT	0.418													7	164					0	0	0.001984	0	0
SIK3	23387	broad.mit.edu	37	11	116729203	116729203	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:116729203G>A	uc001ppy.2	-	20	2696	c.2660C>T	c.(2659-2661)TCG>TTG	p.S887L	SIK3_uc001ppz.2_Missense_Mutation_p.S726L|SIK3_uc001pqa.2_Missense_Mutation_p.S827L|SIK3_uc001ppw.2_Missense_Mutation_p.S244L|SIK3_uc001ppx.2_Missense_Mutation_p.S265L|SIK3_uc001pqb.2_Missense_Mutation_p.S190L	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	887	Gln-rich.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						CTGTAGTGCCGACGTGGTATA	0.592													216	421					0	0	0.003610	0	0
HEPACAM	220296	broad.mit.edu	37	11	124794749	124794749	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:124794749A>T	uc001qbk.2	-	2	708	c.302T>A	c.(301-303)CTC>CAC	p.L101H	HEPACAM_uc009zbj.2_5'Flank|HEPACAM_uc001qbl.1_Missense_Mutation_p.L101H	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	101	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		ATTTTCAAAGAGTCGGATACG	0.592													7	86					0	0	0.001984	0	0
TP53AIP1	63970	broad.mit.edu	37	11	128807690	128807690	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:128807690G>A	uc001qey.2	-	2	234	c.24C>T	c.(22-24)AGC>AGT	p.S8S	TP53AIP1_uc001qex.2_Silent_p.S8S|TP53AIP1_uc009zcm.1_RNA			Q9HCN2	TPIP1_HUMAN	RecName: Full=p53-regulated apoptosis-inducing protein 1;          Short=p53AIP1;	8					apoptosis	mitochondrion				lung(1)	1						CAGATCTGAAGCTCGCCTCAG	0.597													40	21					0	0	0.002522	0	0
LOC100288778	100288778	broad.mit.edu	37	12	88651	88651	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:88651A>G	uc010scy.1	+	6	715	c.160A>G	c.(160-162)AGC>GGC	p.S54G	LOC100288778_uc010scz.1_RNA|LOC100288778_uc010sdb.1_RNA|LOC100288778_uc010sdc.1_RNA|LOC100288778_uc010sdd.1_Missense_Mutation_p.S54G|LOC100288778_uc010sde.1_Missense_Mutation_p.S54G|LOC100288778_uc010sdf.1_Missense_Mutation_p.S54G|LOC100288778_uc010sdg.1_Missense_Mutation_p.S54G|LOC100288778_uc010sdh.1_RNA					SubName: Full=Actin nucleation promoting factor; Flags: Fragment;												0						TGACCTGCCCAGCATTGCCAA	0.587													4	1					0	0	0.000602	0	0
KCNA6	3742	broad.mit.edu	37	12	4919899	4919899	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:4919899C>T	uc001qng.2	+	1	1558	c.692C>T	c.(691-693)TCC>TTC	p.S231F		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	231						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						GAAGACGATTCCTACACATTT	0.547										HNSCC(72;0.22)			34	88					0	0	0.002836	0	0
CHD4	1108	broad.mit.edu	37	12	6707398	6707398	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:6707398G>A	uc001qpo.2	-	11	1840	c.1676C>T	c.(1675-1677)TCT>TTT	p.S559F	CHD4_uc001qpn.2_Missense_Mutation_p.S552F|CHD4_uc001qpp.2_Missense_Mutation_p.S556F	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	559	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTGCAGTTCAGAAACCCAGGA	0.517													48	168					0	0	0.003610	0	0
C1RL	51279	broad.mit.edu	37	12	7254617	7254617	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:7254617G>A	uc001qsn.2	-	3	384	c.367C>T	c.(367-369)CCT>TCT	p.P123S	C1RL_uc009zft.2_Missense_Mutation_p.P123S|C1RL_uc001qso.1_Missense_Mutation_p.P123S	NM_016546	NP_057630	Q9NZP8	C1RL_HUMAN	complement component 1, r subcomponent-like	123	CUB.				complement activation, classical pathway|innate immune response|proteolysis		serine-type endopeptidase activity			pancreas(1)	1						CTCTGACCAGGGGGCCTGCCC	0.592													53	122					0	0	0.003610	0	0
LOC653113	653113	broad.mit.edu	37	12	8384397	8384397	+	RNA	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:8384397C>G	uc010sgk.1	-	5		c.1391G>C				NR_024254				Homo sapiens family with sequence similarity 86, member A pseudogene (LOC653113), non-coding RNA.												0						CCCCAGGGCCCCTGCTGTCCT	0.587													3	38					0	0	0.001984	0	0
A2ML1	144568	broad.mit.edu	37	12	8994057	8994058	+	Missense_Mutation	DNP	GG	AA	AA	rs75353365		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:8994057_8994058GG>AA	uc001quz.3	+	11	1271_1272	c.1173_1174GG>AA	c.(1171-1176)CTGGTT>CTAATT	p.V392I	A2ML1_uc001qva.1_5'Flank	NM_144670	NP_653271	A8K2U0	A2ML1_HUMAN	alpha-2-macroglobulin-like 1 precursor	236						extracellular space	endopeptidase inhibitor activity			ovary(2)|skin(1)	3						ACCAGACCCTGGTTACTGATAA	0.485													50	40					0	0	0.004672	0	0
ATF7IP	55729	broad.mit.edu	37	12	14578076	14578076	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:14578076G>A	uc001rbw.2	+	2	1385	c.1227G>A	c.(1225-1227)ACG>ACA	p.T409T	ATF7IP_uc010shs.1_Silent_p.T409T|ATF7IP_uc001rbu.2_Silent_p.T409T|ATF7IP_uc001rbv.1_Silent_p.T409T|ATF7IP_uc001rbx.2_Silent_p.T409T|ATF7IP_uc010sht.1_Silent_p.T409T|ATF7IP_uc001rby.3_Silent_p.T409T|ATF7IP_uc001rbz.1_Silent_p.T409T|ATF7IP_uc001rca.2_Silent_p.T409T|ATF7IP_uc001rcb.2_Silent_p.T20T	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	409	Glu-rich.				DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TTGTAGAAACGATTAATGAAA	0.338													12	50					0	0	0.000978	0	0
GUCY2C	2984	broad.mit.edu	37	12	14849181	14849181	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:14849181G>C	uc001rcd.2	-	1	339	c.202C>G	c.(202-204)CGT>GGT	p.R68G	GUCY2C_uc009zhz.2_Missense_Mutation_p.R68G	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	68	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TTTTGCAGACGTCCTCTCACT	0.448													7	22					0	0	0.004482	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18435178	18435178	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:18435178G>A	uc001rdt.2	+	2	279	c.163G>A	c.(163-165)GAG>AAG	p.E55K	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.E55K|PIK3C2G_uc010sic.1_5'UTR	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	55					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TCCACACTACGAGAGTGAAAT	0.398													12	38					0	0	0.001368	0	0
LST-3TM12	338821	broad.mit.edu	37	12	21196278	21196278	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:21196278G>A	uc010sin.1	+	6	597	c.597G>A	c.(595-597)AGG>AGA	p.R199R	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Silent_p.R246R	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	199						membrane	transporter activity				0						GCACTATCAGGATAACTCCTA	0.378													40	102					0	0	0.003214	0	0
Unknown	0	broad.mit.edu	37	12	31353368	31353368	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:31353368G>A	uc010sjy.1	-	3	362	c.362C>T	c.(361-363)CCT>CTT	p.P121L						RecName: Full=Ovostatin homolog 1; Flags: Precursor;																		TTTCTGTCCAGGCTTGTAGGT	0.413													9	26					0	0	0.008291	0	0
RACGAP1P	83956	broad.mit.edu	37	12	45458870	45458870	+	RNA	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:45458870C>T	uc001rol.2	-	1		c.325G>A				NR_026583				Homo sapiens FKSG42 (FKSG42) mRNA, complete cds.												0						CGCAGTTAGCCTCAGCTCTCC	0.458													6	7					0	0	0.001984	0	0
COL2A1	1280	broad.mit.edu	37	12	48376722	48376722	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:48376722C>T	uc001rqu.2	-	33	2283	c.2102G>A	c.(2101-2103)CGA>CAA	p.R701Q	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.R632Q	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	701	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TGGGAAACCTCGTTCACCCTG	0.622													24	28					0	0	0.003330	0	0
SLC39A5	283375	broad.mit.edu	37	12	56626590	56626590	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:56626590G>A	uc010sqj.1	+	5	662	c.405G>A	c.(403-405)TCG>TCA	p.S135S	SLC39A5_uc010sqi.1_Silent_p.S26S|SLC39A5_uc010sqk.1_Silent_p.S135S	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	135	Extracellular (By similarity).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						CAGCCCCCTCGGGCCTGGACC	0.617													23	30					0	0	0.003954	0	0
MIP	4284	broad.mit.edu	37	12	56845221	56845221	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:56845221C>T	uc001slh.2	-	4	667	c.635G>A	c.(634-636)GGG>GAG	p.G212E	TIMELESS_uc001slf.2_5'Flank|TIMELESS_uc001slg.2_5'Flank	NM_012064	NP_036196	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	212	Helical; (By similarity).				response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			skin(1)	1						GCCCAGACCCCCTCCAATGAT	0.537													83	70					0	0	0.003610	0	0
TMEM194A	23306	broad.mit.edu	37	12	57472468	57472468	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:57472468C>T	uc001smy.2	-	1	107	c.61G>A	c.(61-63)GGA>AGA	p.G21R	TMEM194A_uc001smx.2_Missense_Mutation_p.G21R|TMEM194A_uc010sra.1_5'UTR	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	21	Helical; (Potential).					integral to membrane					0						CCCCCGACTCCCGAGCCCCAG	0.682													81	54					0	0	0.003610	0	0
C12orf50	160419	broad.mit.edu	37	12	88376933	88376933	+	Missense_Mutation	SNP	C	T	T	rs145797004		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:88376933C>T	uc001tam.1	-	12	1334	c.1166G>A	c.(1165-1167)CGA>CAA	p.R389Q		NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	389										skin(2)|ovary(1)	3						AATTCGTTTTCGCCAGGCTGA	0.279													48	56					0	0	0.003610	0	0
CEP290	80184	broad.mit.edu	37	12	88462406	88462406	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:88462406G>A	uc001tar.2	-	44	6372	c.6028C>T	c.(6028-6030)CCT>TCT	p.P2010S	CEP290_uc001taq.2_Missense_Mutation_p.P1070S	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	2010	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						GAATCTCGAGGAAGAGCTTGG	0.303													50	39					0	0	0.003610	0	0
SELPLG	6404	broad.mit.edu	37	12	109017681	109017681	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:109017681G>A	uc001tni.2	-	2	563	c.403C>T	c.(403-405)CAA>TAA	p.Q135*	SELPLG_uc001tnh.2_Intron|SELPLG_uc010sxe.1_Nonsense_Mutation_p.Q151*	NM_003006	NP_002997	Q14242	SELPL_HUMAN	selectin P ligand	135	2.|Extracellular (Potential).|12 X 10 AA tandem repeats.				blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding				0						GGCACTGGTTGAGTGGTCTGT	0.617													32	98					0	0	0.003271	0	0
ACACB	32	broad.mit.edu	37	12	109623461	109623461	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:109623461C>T	uc001tob.2	+	12	2015	c.1896C>T	c.(1894-1896)CCC>CCT	p.P632P	ACACB_uc001toc.2_Silent_p.P632P	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	632	Biotin carboxylation.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GAGTGACTCCCATTTCTTTTG	0.567													26	22					0	0	0.006320	0	0
CCDC63	160762	broad.mit.edu	37	12	111345145	111345145	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:111345145C>T	uc001trv.1	+	12	1752	c.1557C>T	c.(1555-1557)CCC>CCT	p.P519P	CCDC63_uc010sye.1_Silent_p.P479P|CCDC63_uc001trw.1_Silent_p.P434P	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	519										skin(6)|ovary(1)|pancreas(1)	8						TGGAACAGCCCCTGGACCACA	0.572													15	25					0	0	0.003163	0	0
ALDH2	217	broad.mit.edu	37	12	112235912	112235912	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:112235912G>A	uc001tst.2	+	10	1555	c.1114G>A	c.(1114-1116)GGC>AGC	p.G372S	ALDH2_uc010syi.1_Missense_Mutation_p.G325S|ALDH2_uc009zvy.2_Missense_Mutation_p.G296S	NM_000690	NP_000681	P05091	ALDH2_HUMAN	mitochondrial aldehyde dehydrogenase 2	372					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase|electron carrier activity			skin(2)|ovary(1)|central_nervous_system(1)	4					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	GAAGATCCTCGGCTACATCAA	0.527			T	HMGA2	leiomyoma								10	110					0	0	0.000978	0	0
CDK2AP1	8099	broad.mit.edu	37	12	123749768	123749768	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:123749768C>A	uc001ueq.2	-	3	777	c.255G>T	c.(253-255)AAG>AAT	p.K85N	CDK2AP1_uc001uep.2_RNA	NM_004642	NP_004633	O14519	CDKA1_HUMAN	CDK2-associated protein  1	85					DNA-dependent DNA replication|protein phosphorylation|S phase of mitotic cell cycle	cytoplasm|nucleus	DNA binding|protein binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000554)|Epithelial(86;0.00178)		CCATGGCACTCTTGCTCCCTG	0.577													82	164					8.55712e-49	1.31192e-48	0.003610	1	0
DNAH10	196385	broad.mit.edu	37	12	124272420	124272420	+	Silent	SNP	C	T	T	rs144145237		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:124272420C>T	uc001uft.3	+	10	1333	c.1308C>T	c.(1306-1308)GCC>GCT	p.A436A	DNAH10_uc010tav.1_5'Flank|DNAH10_uc010taw.1_5'Flank	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	436	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGAAAAAGGCCTATTTTGACA	0.557													11	30					0	0	0.001368	0	0
DDX51	317781	broad.mit.edu	37	12	132626121	132626121	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr12:132626121G>A	uc001ujy.3	-	7	1065	c.1026C>T	c.(1024-1026)ATC>ATT	p.I342I	NOC4L_uc001ujz.1_5'Flank	NM_175066	NP_778236	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	342	Helicase ATP-binding.				rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			lung(1)|pancreas(1)	2	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		TGGCTACCACGATGTCAGCCA	0.637													28	28					0	0	0.003271	0	0
KL	9365	broad.mit.edu	37	13	33635527	33635527	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:33635527C>T	uc001uus.2	+	4	2319	c.2311C>T	c.(2311-2313)CCA>TCA	p.P771S	KL_uc001uur.1_3'UTR	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	771	Glycosyl hydrolase-1 2.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TGGAGATTATCCATGGGTGAT	0.443													22	52					0	0	0.003330	0	0
C13orf36	400120	broad.mit.edu	37	13	37269359	37269359	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:37269359C>T	uc001uvt.3	+	2	590	c.144C>T	c.(142-144)TTC>TTT	p.F48F		NM_203451	NP_982276	A2A2V5	CM036_HUMAN	hypothetical protein LOC400120	48	Helical; (Potential).					integral to membrane				skin(1)	1						TGTCCATATTCCTCAGCCTTT	0.478													92	96					0	0	0.003610	0	0
FREM2	341640	broad.mit.edu	37	13	39262547	39262547	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:39262547A>G	uc001uwv.2	+	1	1375	c.1066A>G	c.(1066-1068)ATC>GTC	p.I356V		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	356	CSPG 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGACCTGTTGATCTTCAACCT	0.577													26	61					0	0	0.003330	0	0
CDADC1	81602	broad.mit.edu	37	13	49860415	49860415	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:49860415G>A	uc001vcu.2	+	9	1544	c.1468G>A	c.(1468-1470)GAA>AAA	p.E490K	CDADC1_uc010tgk.1_Missense_Mutation_p.E292K|CDADC1_uc001vcv.2_RNA	NM_030911	NP_112173	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1	490							hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		TGAAAGGAGAGAAAGTAAGTA	0.353													33	34					0	0	0.004878	0	0
UTP14C	9724	broad.mit.edu	37	13	52603949	52603949	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:52603949C>T	uc001vgb.2	+	2	1544	c.1009C>T	c.(1009-1011)CAG>TAG	p.Q337*	UTP14C_uc001vgc.2_RNA	NM_021645	NP_067677	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	337	Potential.				cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				ovary(3)|large_intestine(1)|breast(1)	5		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		ACAGAAACTCCAGGTAGCCTC	0.507													17	74					0	0	0.006122	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369802	86369803	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:86369802_86369803CC>TT	uc001vll.1	-	2	1300_1301	c.841_842GG>AA	c.(841-843)GGA>AAA	p.G281K	SLITRK6_uc010afe.1_Missense_Mutation_p.G46K	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	281	Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		ATGTAATGATCCTGAAGGATCC	0.406													17	79					0	0	0.004672	0	0
ABCC4	10257	broad.mit.edu	37	13	95813473	95813473	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:95813473G>A	uc001vmd.3	-	19	2544	c.2425C>T	c.(2425-2427)CCG>TCG	p.P809S	ABCC4_uc010afk.2_Missense_Mutation_p.P762S|ABCC4_uc001vme.2_Missense_Mutation_p.P809S|ABCC4_uc010tih.1_Missense_Mutation_p.P734S	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	809	ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	AATAATACCGGAGCTTTCAGA	0.348													25	15					0	0	0.004656	0	0
ATP4B	496	broad.mit.edu	37	13	114307750	114307750	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr13:114307750C>T	uc001vtz.2	-	3	284	c.242_splice	c.e3-1	p.G81_splice	ATP4B_uc010agy.1_Splice_Site_p.G81_splice	NM_000705	NP_000696	P51164	ATP4B_HUMAN	hydrogen/potassium-exchanging ATPase 4B						ATP biosynthetic process	integral to membrane|plasma membrane	hydrogen:potassium-exchanging ATPase activity|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung NSC(43;0.0113)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.00696)|all_epithelial(44;0.00347)|all_lung(25;0.0221)|Breast(118;0.0411)|Lung NSC(25;0.0839)	all cancers(43;0.171)		Rabeprazole(DB01129)	AAGGTTACCCCTGGAGAGAGA	0.522													30	38					0	0	0.008361	0	0
OR11H12	440153	broad.mit.edu	37	14	19378102	19378102	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:19378102G>A	uc010tkp.1	+	1	509	c.509G>A	c.(508-510)TGG>TAG	p.W170*		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	170	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGATTTCTGTGGTTCCTGATC	0.488													21	309					0	0	0.002096	0	0
POTEG	404785	broad.mit.edu	37	14	19553567	19553567	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:19553567G>A	uc001vuz.1	+	1	203	c.151G>A	c.(151-153)GAT>AAT	p.D51N	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	51										ovary(1)	1						AGACCACGACGATTCTGCTAT	0.602													35	505					0	0	0.003610	0	0
OR4N5	390437	broad.mit.edu	37	14	20612005	20612005	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:20612005C>T	uc010tla.1	+	1	111	c.111C>T	c.(109-111)ATC>ATT	p.I37I		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TCTACCTTATCATCCTCCCTG	0.453													99	112					0	0	0.003610	0	0
TEP1	7011	broad.mit.edu	37	14	20856222	20856222	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:20856222C>G	uc001vxe.2	-	18	2566	c.2526G>C	c.(2524-2526)AAG>AAC	p.K842N	TEP1_uc010ahk.2_Missense_Mutation_p.K192N|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.K734N	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	842					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CTGCAATGAACCTGACATAAA	0.468													18	16					0	0	0.007413	0	0
ABHD4	63874	broad.mit.edu	37	14	23070653	23070653	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:23070653C>T	uc001wgm.2	+	2	174	c.105C>T	c.(103-105)ATC>ATT	p.I35I	ABHD4_uc010tmz.1_Silent_p.I35I|ABHD4_uc010tna.1_Silent_p.I35I|ABHD4_uc010tnb.1_RNA	NM_022060	NP_071343	Q8TB40	ABHD4_HUMAN	abhydrolase domain containing 4	35					lipid catabolic process		hydrolase activity			central_nervous_system(1)	1	all_cancers(95;5.49e-05)			GBM - Glioblastoma multiforme(265;0.0153)		AAGCCAGGATCCTCCAGTGTA	0.562													15	40					0	0	0.004007	0	0
NIN	51199	broad.mit.edu	37	14	51227046	51227046	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:51227046G>A	uc001wym.2	-	17	2119	c.1928C>T	c.(1927-1929)ACC>ATC	p.T643I	NIN_uc001wyi.2_Missense_Mutation_p.T643I|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.T643I|NIN_uc010tqp.1_Missense_Mutation_p.T649I|NIN_uc001wyo.2_Missense_Mutation_p.T643I	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	643	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GCTGACCACGGTTTCGTCCAG	0.453			T	PDGFRB	MPD								22	54					0	0	0.002299	0	0
DDHD1	80821	broad.mit.edu	37	14	53525280	53525281	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:53525280_53525281GG>AA	uc001xai.2	-	9	2136_2137	c.1906_1907CC>TT	c.(1906-1908)CCA>TTA	p.P636L	DDHD1_uc001xaj.2_Missense_Mutation_p.P643L|DDHD1_uc001xah.2_Missense_Mutation_p.P636L|DDHD1_uc001xag.2_Missense_Mutation_p.P218L|DDHD1_uc001xak.1_Missense_Mutation_p.P32L	NM_001160148	NP_001153620	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1 isoform c	636	DDHD.				lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			ovary(2)	2	Breast(41;0.037)					AGTATTTCCTGGGCGGATGCCA	0.381													15	40					0	0	0.004672	0	0
SYNE2	23224	broad.mit.edu	37	14	64692153	64692153	+	Missense_Mutation	SNP	C	T	T	rs149036674		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:64692153C>T	uc001xgm.2	+	115	20797	c.20567C>T	c.(20566-20568)TCC>TTC	p.S6856F	SYNE2_uc001xgl.2_Missense_Mutation_p.S6878F|SYNE2_uc010apy.2_Missense_Mutation_p.S3241F|SYNE2_uc001xgn.2_Missense_Mutation_p.S1817F|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.S826F|SYNE2_uc001xgq.2_Missense_Mutation_p.S1235F|SYNE2_uc001xgr.2_Missense_Mutation_p.S639F|SYNE2_uc010tsi.1_Missense_Mutation_p.S513F|SYNE2_uc001xgs.2_Missense_Mutation_p.S527F|SYNE2_uc001xgt.2_Missense_Mutation_p.S400F	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6856	Perinuclear space (Potential).|KASH.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ctgcCCTCCTCCGAAGAAGAC	0.473													9	29					0	0	0.006214	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713840	70713840	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:70713840C>T	uc010ttg.1	-	1	679	c.28G>A	c.(28-30)GTA>ATA	p.V10I		NR_003951				SubName: Full=ADAM21-like protein;												0						TGGCGTGCTACTTCCTTCTCT	0.458													17	41					0	0	0.004007	0	0
ADAM21	8747	broad.mit.edu	37	14	70924754	70924754	+	Missense_Mutation	SNP	G	A	A	rs143022031	byFrequency	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:70924754G>A	uc001xmd.2	+	1	538	c.538G>A	c.(538-540)GTA>ATA	p.V180I		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	180					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGAGAAGGAAGTAGCACGCCA	0.458													7	58					0	0	0.001984	0	0
MIR1260	100302236	broad.mit.edu	37	14	77732602	77732602	+	RNA	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:77732602C>T	hsa-mir-1260|MI0006394	+			c.42C>T			NGB_uc001xtg.1_3'UTR																	0						AAACACTCATCGCGGGGTCAG	0.552													13	57					0	0	0.002450	0	0
VIPAR	63894	broad.mit.edu	37	14	77894796	77894796	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:77894796G>A	uc001xtt.1	-	20	1716	c.1378C>T	c.(1378-1380)CGT>TGT	p.R460C	VIPAR_uc001xtu.1_Missense_Mutation_p.R460C|VIPAR_uc010tvj.1_Missense_Mutation_p.R411C|VIPAR_uc001xtv.1_Missense_Mutation_p.R460C	NM_022067	NP_071350	Q9H9C1	VIPAR_HUMAN	hypothetical protein LOC63894	460					endosome to lysosome transport|intracellular protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	early endosome|late endosome|recycling endosome	protein binding			central_nervous_system(1)	1						AACTGTTGACGATCCTTCAGG	0.453													16	23					0	0	0.008871	0	0
TC2N	123036	broad.mit.edu	37	14	92268739	92268739	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:92268739G>A	uc001xzu.3	-	4	519	c.328C>T	c.(328-330)CGA>TGA	p.R110*	TC2N_uc001xzt.3_Nonsense_Mutation_p.R110*|TC2N_uc010auc.2_Nonsense_Mutation_p.R110*|TC2N_uc001xzv.3_Nonsense_Mutation_p.R110*	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	110						nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		TCTACCTTTCGATCTCCAAAA	0.418													9	33					0	0	0.008291	0	0
RIN3	79890	broad.mit.edu	37	14	93154591	93154591	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:93154591C>T	uc001yap.2	+	10	3104	c.2952C>T	c.(2950-2952)TTC>TTT	p.F984F	RIN3_uc010auk.2_Silent_p.F646F|RIN3_uc001yaq.2_Silent_p.F909F	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	984					endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				AGCCCAACTTCCTGTGAGGCC	0.751													11	12					0	0	0.001368	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418350	105418350	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:105418350C>T	uc010axc.1	-	7	3558	c.3438G>A	c.(3436-3438)GAG>GAA	p.E1146E	AHNAK2_uc001ypx.2_Silent_p.E1046E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1146						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACAGTTCCCCCTCCAGCCGCG	0.632													74	188					0	0	0.003610	0	0
ADAM6	8755	broad.mit.edu	37	14	106512281	106512281	+	RNA	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:106512281C>T	uc010tyt.1	-	1667		c.33410G>A								Parts of antibodies, mostly variable regions.												0						CCTGGGAATCCCGGGGCTGAG	0.527													7	22					0	0	0.001984	0	0
ADAM6	8755	broad.mit.edu	37	14	106653536	106653536	+	RNA	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:106653536C>T	uc010tyt.1	-	971		c.23427G>A								Parts of antibodies, mostly variable regions.												0						ACTCCAGCCCCTTTCCTGGAG	0.557													38	135					0	0	0.006999	0	0
ADAM6	8755	broad.mit.edu	37	14	106725222	106725222	+	RNA	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:106725222C>T	uc010tyt.1	-	588		c.18325G>A								Parts of antibodies, mostly variable regions.												0						AATATACGGCCGTGTCCTCGG	0.547													41	274					0	0	0.002852	0	0
ADAM6	8755	broad.mit.edu	37	14	107034897	107034897	+	RNA	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr14:107034897C>T	uc010tyt.1	-	154		c.7336G>A			uc001ysz.2_Silent_p.G61G					Parts of antibodies, mostly variable regions.												0						CCAGGCCTTTCCCGGGCATCT	0.562													28	14					0	0	0.005443	0	0
MKRN3	7681	broad.mit.edu	37	15	23811889	23811889	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:23811889G>A	uc001ywh.3	+	1	1436	c.960G>A	c.(958-960)GAG>GAA	p.E320E	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.E320E	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	320	RING-type.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TTGTCTATGAGAAGGCCAACC	0.507													32	34					0	0	0.003271	0	0
C15orf2	23742	broad.mit.edu	37	15	24921168	24921168	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:24921168C>T	uc001ywo.2	+	1	628	c.154C>T	c.(154-156)CGC>TGC	p.R52C		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	52					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CGGCCTGTTCCGCCGGAACGC	0.751													14	50					0	0	0.004007	0	0
RASGRP1	10125	broad.mit.edu	37	15	38792333	38792333	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:38792333C>T	uc001zke.3	-	14	1869	c.1691G>A	c.(1690-1692)GGA>GAA	p.G564E	RASGRP1_uc010bbe.2_RNA|RASGRP1_uc010bbf.2_Missense_Mutation_p.G391E|RASGRP1_uc010bbg.2_Missense_Mutation_p.G391E|RASGRP1_uc001zkd.3_Missense_Mutation_p.G529E	NM_005739	NP_005730	O95267	GRP1_HUMAN	RAS guanyl releasing protein 1 isoform a	564	Phorbol-ester/DAG-type.				cell differentiation|platelet activation|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|lipid binding|protein binding			large_intestine(1)|ovary(1)	2		all_cancers(109;6.38e-17)|all_epithelial(112;5.51e-15)|Lung NSC(122;2.12e-11)|all_lung(180;5.63e-10)|Melanoma(134;0.0574)		GBM - Glioblastoma multiforme(113;1.97e-07)|BRCA - Breast invasive adenocarcinoma(123;0.00248)		TTTGATCACTCCCCAGAGCTA	0.318													33	120					0	0	0.004878	0	0
SLC12A1	6557	broad.mit.edu	37	15	48539583	48539583	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:48539583G>A	uc001zwn.3	+	13	1826	c.1610G>A	c.(1609-1611)GGA>GAA	p.G537E	SLC12A1_uc010uew.1_Missense_Mutation_p.G343E|SLC12A1_uc010bem.2_Missense_Mutation_p.G537E|SLC12A1_uc001zwq.3_Missense_Mutation_p.G308E|SLC12A1_uc001zwr.3_Missense_Mutation_p.G264E	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	537	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	TTTGCAAAGGGATATGGGAAA	0.348													31	33					0	0	0.003271	0	0
FBN1	2200	broad.mit.edu	37	15	48782256	48782256	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:48782256G>A	uc001zwx.1	-	25	3202	c.2874C>T	c.(2872-2874)TGC>TGT	p.C958C		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	958	TB 5.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACCTCAGGAAGCAGGTTTCCA	0.587													19	23					0	0	0.007413	0	0
FBN1	2200	broad.mit.edu	37	15	48807600	48807600	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:48807600G>A	uc001zwx.1	-	12	1780	c.1452C>T	c.(1450-1452)CTC>CTT	p.L484L		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	484	EGF-like 6.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACTCCCCACGGAGGTCCAGCT	0.453													43	21					0	0	0.003610	0	0
C15orf33	196951	broad.mit.edu	37	15	49659751	49659751	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:49659751C>T	uc001zxl.2	-	13	1459	c.1165G>A	c.(1165-1167)GGT>AGT	p.G389S		NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	389										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		GGACTCTGACCTCCAAAATTG	0.353													33	22					0	0	0.001786	0	0
DMXL2	23312	broad.mit.edu	37	15	51772994	51772994	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:51772994G>A	uc002abf.2	-	24	6534	c.6309C>T	c.(6307-6309)TCC>TCT	p.S2103S	DMXL2_uc002abd.2_Silent_p.S173S|DMXL2_uc010ufy.1_Silent_p.S2103S|DMXL2_uc010bfa.2_Silent_p.S1467S	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	2103						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		TCTCTACTTTGGAATATGTCT	0.378													52	56					0	0	0.003610	0	0
LDHAL6B	92483	broad.mit.edu	37	15	59500161	59500161	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:59500161C>A	uc002agb.2	+	1	1120	c.1022C>A	c.(1021-1023)CCT>CAT	p.P341H	MYO1E_uc002aga.2_Intron	NM_033195	NP_149972	Q9BYZ2	LDH6B_HUMAN	lactate dehydrogenase A-like 6B	341					glycolysis	cytoplasm	L-lactate dehydrogenase activity|protein binding				0					NADH(DB00157)	CTCAGTATTCCTTGTATCCTG	0.383													6	111					0.00198382	0.00297722	0.001984	1	0
CILP	8483	broad.mit.edu	37	15	65491300	65491300	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:65491300C>T	uc002aon.2	-	9	1505	c.1324G>A	c.(1324-1326)GAT>AAT	p.D442N		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	442					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						ATCCCATTATCCTGCTGCCCT	0.537													14	42					0	0	0.003163	0	0
CYP1A2	1544	broad.mit.edu	37	15	75042580	75042580	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:75042580G>A	uc002ayr.1	+	2	565	c.501G>A	c.(499-501)AAG>AAA	p.K167K		NM_000761	NP_000752	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A,	167					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			ovary(3)|breast(1)	4					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	ATGTGAGCAAGGAGGCTAAGG	0.612													45	107					0	0	0.003610	0	0
CSK	1445	broad.mit.edu	37	15	75094397	75094397	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:75094397C>T	uc010bkb.1	+	13	1326	c.1143C>T	c.(1141-1143)TCC>TCT	p.S381S	CSK_uc002ays.2_Silent_p.S381S|CSK_uc010bkc.1_Silent_p.S190S	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	381	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						AAATCTACTCCTTTGGGCGAG	0.542													29	89					0	0	0.002836	0	0
RASGRF1	5923	broad.mit.edu	37	15	79341874	79341874	+	Silent	SNP	G	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:79341874G>T	uc002beq.2	-	4	963	c.588C>A	c.(586-588)CCC>CCA	p.P196P	RASGRF1_uc002bep.2_Silent_p.P196P|RASGRF1_uc010blm.1_Silent_p.P118P|RASGRF1_uc002ber.3_Silent_p.P196P	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	196					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						CTTCATCGTTGGGGGCGACAG	0.552													36	33					6.99958e-10	1.06492e-09	0.006999	1	0
IL16	3603	broad.mit.edu	37	15	81591938	81591939	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:81591938_81591939CC>TT	uc002bgh.3	+	14	2647_2648	c.2271_2272CC>TT	c.(2269-2274)ACCCCA>ACTTCA	p.P758S	IL16_uc010blq.1_Missense_Mutation_p.P712S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.P800S|IL16_uc002bgg.2_Missense_Mutation_p.P758S|IL16_uc002bgi.1_Missense_Mutation_p.P148S|IL16_uc002bgj.2_Missense_Mutation_p.P252S|IL16_uc002bgk.2_Missense_Mutation_p.P57S|IL16_uc002bgl.1_Missense_Mutation_p.P57S|IL16_uc010unq.1_Missense_Mutation_p.P57S	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	758					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						CAGATGGGACCCCACCAAAGCT	0.554													21	85					0	0	0.004672	0	0
POLG	5428	broad.mit.edu	37	15	89873432	89873432	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:89873432G>A	uc002bns.3	-	3	1017	c.735C>T	c.(733-735)ATC>ATT	p.I245I	POLG_uc002bnr.3_Silent_p.I245I	NM_002693	NP_002684	P54098	DPOG1_HUMAN	DNA-directed DNA polymerase gamma	245					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			ovary(1)|lung(1)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			CCTCCAGGGGGATGAGGTCAG	0.612								DNA_polymerases_(catalytic_subunits)					41	27					0	0	0.008740	0	0
WDR93	56964	broad.mit.edu	37	15	90270552	90270552	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr15:90270552C>T	uc002boj.2	+	9	1146	c.1045C>T	c.(1045-1047)CCA>TCA	p.P349S	WDR93_uc010bnr.2_Missense_Mutation_p.P349S|WDR93_uc010upz.1_Missense_Mutation_p.P66S	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	349					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			GGAGGAAGAGCCACTCAGGTG	0.532													5	30					0	0	0.000602	0	0
WDR90	197335	broad.mit.edu	37	16	706315	706315	+	Silent	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:706315C>G	uc002cii.1	+	18	2034	c.1980C>G	c.(1978-1980)CCC>CCG	p.P660P	WDR90_uc002cig.1_3'UTR|WDR90_uc002cih.1_3'UTR|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.P187P|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	660	WD 5.									ovary(1)	1		Hepatocellular(780;0.0218)				ACGAGGGCCCCGTCAGCTCAG	0.697													23	22					0	0	0.007291	0	0
WDR24	84219	broad.mit.edu	37	16	737679	737679	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:737679G>A	uc002ciz.1	-	2	1302	c.542C>T	c.(541-543)TCC>TTC	p.S181F		NM_032259	NP_115635	Q96S15	WDR24_HUMAN	WD repeat domain 24	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(1)|central_nervous_system(1)	2		Hepatocellular(780;0.0218)				CTCAAAGGTGGAGGCGAAGGT	0.632													23	23					0	0	0.002299	0	0
CACNA1H	8912	broad.mit.edu	37	16	1260630	1260630	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:1260630C>T	uc002cks.2	+	20	4265	c.4017C>T	c.(4015-4017)TTC>TTT	p.F1339F	CACNA1H_uc002ckt.2_Silent_p.F1339F|CACNA1H_uc002cku.2_Silent_p.F45F|CACNA1H_uc010brj.2_Silent_p.F45F|CACNA1H_uc002ckv.2_Silent_p.F45F	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1339	Helical; Name=S2 of repeat III; (Potential).|III.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGGCCATCTTCGTGGCGGAGA	0.677													14	23					0	0	0.004990	0	0
CORO7	79585	broad.mit.edu	37	16	4463325	4463325	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:4463325G>A	uc002cwh.3	-	2	261	c.141C>T	c.(139-141)TTC>TTT	p.F47F	CORO7_uc002cwf.2_Silent_p.F47F|CORO7_uc002cwg.3_5'UTR|CORO7_uc010uxh.1_Silent_p.F47F|CORO7_uc010uxi.1_Silent_p.F47F|CORO7_uc010uxj.1_Intron|CORO7_uc010btp.1_5'UTR|CORO7_uc010btr.1_Intron	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7	47						cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						GGTCGGAGTTGAAGGCGATCA	0.517													9	5					0	0	0.004482	0	0
SEC14L5	9717	broad.mit.edu	37	16	5056031	5056031	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:5056031C>T	uc002cye.2	+	12	1599	c.1419C>T	c.(1417-1419)TTC>TTT	p.F473F		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	473	CRAL-TRIO.					integral to membrane|intracellular	transporter activity				0						TCCCTGACTTCCTTGGGGGAG	0.587													23	33					0	0	0.004656	0	0
C16orf75	116028	broad.mit.edu	37	16	11444533	11444533	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:11444533C>T	uc002daw.1	+	2	348	c.330C>T	c.(328-330)GCC>GCT	p.A110A	C16orf75_uc002daq.1_RNA	NM_152308	NP_689521	Q96E14	RMI2_HUMAN	RecQ-mediated genome instability protein 2	110	OB.				DNA replication	nucleus	DNA binding				0						TGGTTCAGGCCTGCAGCCCTG	0.383			T	CIITA	PMBL|Hodgkin Lymphona|								21	163					0	0	0.002299	0	0
NPIP	9284	broad.mit.edu	37	16	15045785	15045785	+	Nonsense_Mutation	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:15045785C>G	uc002dcy.3	+	8	956	c.956C>G	c.(955-957)TCA>TGA	p.S319*	NPIP_uc002dcx.3_RNA	NM_006985	NP_008916	Q9UND3	NPIP_HUMAN	nuclear pore complex interacting protein	319	Pro-rich.				mRNA transport|protein transport|transmembrane transport	nuclear membrane|nuclear pore					0						CTTCCACCCTCAGCTCCACCC	0.542													18	81					0	0	0.001523	0	0
ERN2	10595	broad.mit.edu	37	16	23707279	23707279	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:23707279C>T	uc002dma.3	-	14	1859	c.1690G>A	c.(1690-1692)GGG>AGG	p.G564R	ERN2_uc010bxp.2_Missense_Mutation_p.G512R	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	516	Cytoplasmic (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GAAATCTTCCCCACTACGGTG	0.637													10	54					0	0	0.001368	0	0
SRCAP	10847	broad.mit.edu	37	16	30740755	30740755	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:30740755C>T	uc002dze.1	+	27	6374	c.5989C>T	c.(5989-5991)CCT>TCT	p.P1997S	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.P1792S	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1997					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCACCCACCTCCTTGGCTGGC	0.592													33	40					0	0	0.001786	0	0
SETD1A	9739	broad.mit.edu	37	16	30977153	30977153	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:30977153C>T	uc002ead.1	+	8	2637	c.1951C>T	c.(1951-1953)CCA>TCA	p.P651S		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	651	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCCACCTCCTCCACCACCCCC	0.627													27	52					0	0	0.005443	0	0
MYLK3	91807	broad.mit.edu	37	16	46782006	46782006	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:46782006C>T	uc002eei.3	-	1	216	c.100G>A	c.(100-102)GAG>AAG	p.E34K	MYLK3_uc010vge.1_Intron	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	34					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCACCTTCTCGTTCAGCATG	0.577													39	61					0	0	0.003214	0	0
ADCY7	113	broad.mit.edu	37	16	50338390	50338390	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:50338390C>T	uc002egd.1	+	10	1756	c.1488C>T	c.(1486-1488)CCC>CCT	p.P496P	ADCY7_uc002egb.1_Silent_p.P496P|ADCY7_uc002egc.1_Silent_p.P496P	NM_001114	NP_001105	P51828	ADCY7_HUMAN	adenylate cyclase 7	496	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			skin(1)	1		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	CGGCACGGCCCTTTGCACATC	0.677													48	68					0	0	0.003610	0	0
NOD2	64127	broad.mit.edu	37	16	50744993	50744993	+	Missense_Mutation	SNP	C	T	T	rs104895481		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:50744993C>T	uc002egm.1	+	4	1276	c.1171C>T	c.(1171-1173)CGT>TGT	p.R391C	NOD2_uc010cbk.1_Missense_Mutation_p.R364C|NOD2_uc002egl.1_Missense_Mutation_p.R169C|NOD2_uc010cbl.1_Missense_Mutation_p.R169C|NOD2_uc010cbm.1_Missense_Mutation_p.R169C|NOD2_uc010cbn.1_RNA|NOD2_uc010cbo.1_RNA|NOD2_uc010cbp.1_5'Flank|NOD2_uc010cbq.1_5'Flank|NOD2_uc010cbr.1_5'Flank	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	391	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				GTTCACGGATCGTGAACGCCA	0.547													48	54					0	0	0.003610	0	0
SALL1	6299	broad.mit.edu	37	16	51171098	51171098	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:51171098C>T	uc010vgs.1	-	3	3931	c.3900G>A	c.(3898-3900)ATG>ATA	p.M1300I	SALL1_uc010vgr.1_Missense_Mutation_p.M1203I|SALL1_uc010cbv.2_Missense_Mutation_p.M152I	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1300					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CACTGCTTGCCATTTTCTCCA	0.582													21	51					0	0	0.002299	0	0
MMP15	4324	broad.mit.edu	37	16	58074457	58074457	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:58074457G>A	uc002ena.2	+	5	1738	c.765G>A	c.(763-765)CTG>CTA	p.L255L		NM_002428	NP_002419	P51511	MMP15_HUMAN	matrix metalloproteinase 15 preproprotein	255	Extracellular (Potential).				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			central_nervous_system(2)|breast(1)	3						ACCTCTTCCTGGTGGCAGTGC	0.612													26	41					0	0	0.006320	0	0
LOC283867	283867	broad.mit.edu	37	16	65397140	65397140	+	RNA	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:65397140G>A	uc010cdo.1	-	2		c.201C>T			LOC283867_uc010cdp.1_RNA|LOC283867_uc002eol.1_RNA					Homo sapiens cDNA clone IMAGE:5276218.												0				OV - Ovarian serous cystadenocarcinoma(108;0.17)		GACAGTCATTGAACACAGTAG	0.398													37	61					0	0	0.006999	0	0
NFATC3	4775	broad.mit.edu	37	16	68217229	68217229	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:68217229G>A	uc002evo.1	+	8	2268	c.2058G>A	c.(2056-2058)AAG>AAA	p.K686K	NFATC3_uc010vkl.1_Silent_p.K207K|NFATC3_uc010vkm.1_Silent_p.K207K|NFATC3_uc010vkn.1_Silent_p.K207K|NFATC3_uc010vko.1_Silent_p.K207K|NFATC3_uc010vkp.1_Silent_p.K207K|NFATC3_uc010vkq.1_Silent_p.K207K|NFATC3_uc002evl.2_Silent_p.K207K|NFATC3_uc002evk.2_Silent_p.K686K|NFATC3_uc002evm.1_Silent_p.K686K|NFATC3_uc002evn.1_Silent_p.K686K|NFATC3_uc010vkr.1_Silent_p.K207K|NFATC3_uc010vks.1_Silent_p.K207K|NFATC3_uc010vkt.1_Silent_p.K207K|NFATC3_uc010vku.1_Silent_p.K207K|NFATC3_uc010vkv.1_Silent_p.K207K|NFATC3_uc010vkw.1_Silent_p.K207K|NFATC3_uc010vkx.1_Silent_p.K207K|NFATC3_uc010vky.1_Silent_p.K207K|NFATC3_uc010vkz.1_Silent_p.K207K|NFATC3_uc010vla.1_Silent_p.K207K|NFATC3_uc010vlb.1_Silent_p.K207K|NFATC3_uc010vlc.1_Silent_p.K207K	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	686	Nuclear localization signal.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GCAATGGCAAGAGGAAAAAAA	0.398													43	73					0	0	0.002222	0	0
PDXDC2	283970	broad.mit.edu	37	16	70012005	70012005	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:70012005G>C	uc010vlq.1	-	6	699	c.521C>G	c.(520-522)TCT>TGT	p.S174C	CLEC18C_uc002exy.2_Intron|PDXDC2_uc002eyb.2_RNA|PDXDC2_uc002eyc.2_RNA					SubName: Full=Putative uncharacterized protein;												0						CTTTCTTGCAGAGGGGGTGAT	0.458													4	286					0	0	0.000248	0	0
Unknown	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:70268158A>C	uc010cfp.1	-	3		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333													2	13					0	0	0.004672	0	0
HYDIN	54768	broad.mit.edu	37	16	71015463	71015463	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:71015463G>A	uc002ezr.2	-	29	4466	c.4338C>T	c.(4336-4338)ATC>ATT	p.I1446I		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1447										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GATGTGAACTGATAAAGCCCT	0.383													26	106					0	0	0.008361	0	0
CHST6	4166	broad.mit.edu	37	16	75513664	75513664	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:75513664G>A	uc002fef.2	-	3	243	c.63C>T	c.(61-63)CTC>CTT	p.L21L	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.L21L	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	21	Helical; Signal-anchor for type II membrane protein; (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						GAAAGAGGAGGAGGAAGGTCT	0.701													7	14					0	0	0.001984	0	0
PKD1L2	114780	broad.mit.edu	37	16	81164149	81164149	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:81164149C>T	uc002fgh.1	-	36	5958	c.5958G>A	c.(5956-5958)AGG>AGA	p.R1986R	PKD1L2_uc002fgf.1_5'UTR|PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1986	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTGAAAAGCCCCTGGTGAAGC	0.592													7	8					0	0	0.001984	0	0
KIAA1609	57707	broad.mit.edu	37	16	84529504	84529504	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:84529504C>T	uc002fib.2	-	3	276	c.169G>A	c.(169-171)GCT>ACT	p.A57T	KIAA1609_uc010vod.1_Missense_Mutation_p.A30T|KIAA1609_uc002fic.2_RNA	NM_020947	NP_065998	Q6P9B6	K1609_HUMAN	hypothetical protein LOC57707	57							protein binding			ovary(2)	2						GGGGGAAGAGCTTCCCCGACG	0.473													45	74					0	0	0.003610	0	0
OR1E1	8387	broad.mit.edu	37	17	3301561	3301561	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:3301561G>A	uc002fvj.1	-	1	144	c.144C>T	c.(142-144)CTC>CTT	p.L48L		NM_003553	NP_003544	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCAGTCGAATGAGGACAATGA	0.517													31	43					0	0	0.006230	0	0
KIF1C	10749	broad.mit.edu	37	17	4927149	4927149	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:4927149C>T	uc002gan.1	+	23	3341	c.3015C>T	c.(3013-3015)CCC>CCT	p.P1005P		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	1005	Pro-rich.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						CGCTCCAACCCCCTGAGGAGG	0.687													36	37					0	0	0.003271	0	0
NLRP1	22861	broad.mit.edu	37	17	5463221	5463221	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:5463221G>A	uc002gci.2	-	4	1350	c.795C>T	c.(793-795)TCC>TCT	p.S265S	NLRP1_uc002gcg.1_Silent_p.S265S|NLRP1_uc002gck.2_Silent_p.S265S|NLRP1_uc002gcj.2_Silent_p.S265S|NLRP1_uc002gcl.2_Silent_p.S265S|NLRP1_uc002gch.3_Silent_p.S265S|NLRP1_uc010clh.2_Silent_p.S265S	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	265					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				AGGGCCATGTGGAACAGAGGC	0.557													54	154					0	0	0.003610	0	0
MYH1	4619	broad.mit.edu	37	17	10399285	10399285	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:10399285A>G	uc002gmo.2	-	35	5245	c.5151T>C	c.(5149-5151)GTT>GTC	p.V1717V	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1717	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GCAGGAGCTGAACACGCTCAC	0.483													17	35					0	0	0.004007	0	0
MYH1	4619	broad.mit.edu	37	17	10401165	10401165	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:10401165G>A	uc002gmo.2	-	31	4345	c.4251C>T	c.(4249-4251)TCC>TCT	p.S1417S	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1417	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCTTCTCAAGGGAAGCACATT	0.478													25	64					0	0	0.003954	0	0
MYH2	4620	broad.mit.edu	37	17	10432283	10432283	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:10432283C>T	uc010coi.2	-	27	3596	c.3468G>A	c.(3466-3468)CTG>CTA	p.L1156L	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.L1156L|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1156	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CGGCTTCTTCCAGCCTCTCGC	0.622													48	110					0	0	0.003610	0	0
MYOCD	93649	broad.mit.edu	37	17	12656451	12656451	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:12656451G>A	uc002gnn.2	+	10	2145	c.1846G>A	c.(1846-1848)GAG>AAG	p.E616K	MYOCD_uc002gno.2_Missense_Mutation_p.E616K|MYOCD_uc002gnp.1_Missense_Mutation_p.E520K|MYOCD_uc002gnq.2_Missense_Mutation_p.E335K	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	616					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCATTGTGTGGAGTCCTCAGA	0.517													47	111					0	0	0.003610	0	0
CCDC144A	9720	broad.mit.edu	37	17	16593801	16593801	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:16593801C>T	uc002gqk.1	+	1	163	c.87C>T	c.(85-87)GTC>GTT	p.V29V		NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	29											0						CCCCTAGCGTCGGGAGCCAGG	0.657													24	17					0	0	0.003330	0	0
RASD1	51655	broad.mit.edu	37	17	17398703	17398703	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:17398703C>T	uc002gri.2	-	2	794	c.582G>A	c.(580-582)ATG>ATA	p.M194I		NM_016084	NP_057168	Q9Y272	RASD1_HUMAN	RAS, dexamethasone-induced 1 precursor	194					G-protein coupled receptor protein signaling pathway|small GTPase mediated signal transduction	nucleus|perinuclear region of cytoplasm|plasma membrane	GTP binding|GTPase activity				0						GCAGCTTGGCCATGGCGAAGA	0.637													6	12					0	0	0.003080	0	0
NLK	51701	broad.mit.edu	37	17	26370206	26370206	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:26370206C>T	uc010crj.2	+	1	519	c.307C>T	c.(307-309)CCT>TCT	p.P103S	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	103					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GGGGCAGGCTCCTGGACCAGC	0.473													26	32					0	0	0.003330	0	0
FOXN1	8456	broad.mit.edu	37	17	26861510	26861510	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:26861510G>A	uc010crm.2	+	7	1287	c.1089G>A	c.(1087-1089)TGG>TGA	p.W363*	FOXN1_uc002hbj.2_Nonsense_Mutation_p.W363*	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	363	Fork-head.				defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					TGCAAAAATGGAAGAGGAAAG	0.567													12	36					0	0	0.001368	0	0
SUZ12P	440423	broad.mit.edu	37	17	29061941	29061941	+	RNA	SNP	T	C	C	rs112064181	by1000genomes	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:29061941T>C	uc002hfn.1	+	2		c.1143T>C			SUZ12P_uc002hfo.2_Intron|SUZ12P_uc002hfp.2_RNA|SUZ12P_uc002hfq.2_RNA					Homo sapiens cDNA clone IMAGE:5299523, containing frame-shift errors.												0						TAGATTTCTTTGAACTCGGAA	0.303													5	90					0	0	0.000602	0	0
UTP6	55813	broad.mit.edu	37	17	30222019	30222019	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:30222019A>C	uc002hgr.2	-	3	272	c.189T>G	c.(187-189)AAT>AAG	p.N63K	UTP6_uc010cst.2_5'UTR|UTP6_uc010wbw.1_Missense_Mutation_p.N63K	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	hepatocellular carcinoma-associated antigen 66	63					rRNA processing	nucleolus	binding			ovary(1)	1		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				GCTCCAAAAGATTAATTTCAT	0.289													10	19					0	0	0.001855	0	0
ACCN1	40	broad.mit.edu	37	17	32483265	32483265	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:32483265C>T	uc002hhu.2	-	1	561	c.287G>A	c.(286-288)GGC>GAC	p.G96D		NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	96	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	GAACCGGAAGCCATTCAGGTT	0.577													39	32					0	0	0.006999	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072167	34072167	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:34072167C>T	uc002hjv.1	-	6	2377	c.2349G>A	c.(2347-2349)CGG>CGA	p.R783R		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	783					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGTGGTCTCTCCGGGGCCGAA	0.612													46	149					0	0	0.003610	0	0
SRCIN1	80725	broad.mit.edu	37	17	36720422	36720422	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:36720422C>T	uc002hqd.2	-	4	698	c.473G>A	c.(472-474)AGG>AAG	p.R158K	SRCIN1_uc002hqf.1_5'Flank|SRCIN1_uc002hqe.2_Missense_Mutation_p.R12K|SRCIN1_uc002hqh.1_Missense_Mutation_p.R218K	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	Error:Variant_position_missing_in_Q9C0H9_after_alignment					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						GCGGTTCATCCTGCTGAAGCC	0.701													3	7					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	17	37186539	37186539	+	RNA	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:37186539G>A	uc002hrd.1	+	1		c.381G>A								Homo sapiens cDNA FLJ43826 fis, clone TESTI4002703.																		TCCCCCTAAGGAGGTAGAACC	0.592													4	19					0	0	0.000248	0	0
GSDMB	55876	broad.mit.edu	37	17	38065230	38065230	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:38065230G>A	uc010cwj.2	-	4	647	c.642C>T	c.(640-642)TTC>TTT	p.F214F	GSDMB_uc010cwi.2_5'Flank|GSDMB_uc010cwk.2_Intron|GSDMB_uc010cwl.2_Intron|GSDMB_uc010cwm.2_Intron|GSDMB_uc002htg.2_Silent_p.F214F|GSDMB_uc002hth.2_Silent_p.F214F|GSDMB_uc010wem.1_Silent_p.F214F	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin B isoform 1	214						cytoplasm				breast(1)|pancreas(1)	2						CCTTGTTGGGGAAGACAAGCT	0.532													98	109					0	0	0.003610	0	0
WIPF2	147179	broad.mit.edu	37	17	38430095	38430095	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:38430095C>T	uc002hug.1	+	6	1264	c.1024C>T	c.(1024-1026)CCC>TCC	p.P342S	WIPF2_uc002huh.1_Missense_Mutation_p.P192S|WIPF2_uc010cww.1_Missense_Mutation_p.P192S|WIPF2_uc002hui.1_Missense_Mutation_p.P342S|WIPF2_uc010cwx.1_Missense_Mutation_p.P84S|WIPF2_uc010cwy.1_Missense_Mutation_p.P342S	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	342	Poly-Pro.					cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						TGCTCCCCCTCCCCCACCACC	0.607										HNSCC(43;0.11)			12	48					0	0	0.000978	0	0
CCR7	1236	broad.mit.edu	37	17	38711855	38711855	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:38711855C>T	uc002huw.2	-	3	339	c.276G>A	c.(274-276)ATG>ATA	p.M92I		NM_001838	NP_001829	P32248	CCR7_HUMAN	chemokine (C-C motif) receptor 7 precursor	92	Cytoplasmic (Potential).				cell maturation|immunological synapse formation|inflammatory response|interleukin-12 secretion|lymphocyte migration into lymph node|positive regulation of dendritic cell antigen processing and presentation|positive regulation of glycoprotein biosynthetic process|positive regulation of humoral immune response|positive regulation of hypersensitivity|positive regulation of interleukin-12 production|positive regulation of neutrophil chemotaxis|regulation of interferon-gamma production|regulation of interleukin-1 beta secretion|T cell costimulation	integral to membrane|intracellular	C-C chemokine receptor activity|chemokine (C-C motif) ligand 19 binding|chemokine (C-C motif) ligand 21 binding			breast(1)	1		Breast(137;0.000496)				AGGTATCGGTCATGGTCTTGA	0.552													66	43					0	0	0.003610	0	0
KRT26	353288	broad.mit.edu	37	17	38928008	38928008	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:38928008C>T	uc002hvf.2	-	1	404	c.358G>A	c.(358-360)GAG>AAG	p.E120K		NM_181539	NP_853517	Q7Z3Y9	K1C26_HUMAN	keratin 26	120	Rod.|Linker 1.					intermediate filament	structural molecule activity				0		Breast(137;0.00526)				TCACATTTCTCGTACCAGCCC	0.498													26	80					0	0	0.003330	0	0
KRT15	3866	broad.mit.edu	37	17	39672217	39672217	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:39672217G>A	uc002hwy.2	-	5	1137	c.946C>T	c.(946-948)CAG>TAG	p.Q316*	KRT15_uc002hwz.2_Nonsense_Mutation_p.Q218*|KRT15_uc002hxa.2_Nonsense_Mutation_p.Q151*|KRT15_uc002hxb.1_Nonsense_Mutation_p.Q151*	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	316	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				TTGCTGGTCTGGATCATTTCT	0.592													51	134					0	0	0.003610	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386440	56386440	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:56386440C>T	uc002ivx.3	-	22	5064	c.4193G>A	c.(4192-4194)GGA>GAA	p.G1398E	BZRAP1_uc002ivw.2_5'Flank|BZRAP1_uc010dcs.2_Missense_Mutation_p.G1338E|BZRAP1_uc010wnt.1_Missense_Mutation_p.G1398E	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	1398						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACCAACTAATCCAGGCATGTC	0.647													34	133					0	0	0.003271	0	0
TEX14	56155	broad.mit.edu	37	17	56700313	56700313	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:56700313G>A	uc010dcz.1	-	4	430	c.312C>T	c.(310-312)ATC>ATT	p.I104I	TEX14_uc002iwr.1_Silent_p.I104I|TEX14_uc002iws.1_Silent_p.I104I|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	104	ANK 3.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTTTGCTAAGGATCCACTGAT	0.547													21	23					0	0	0.008871	0	0
MED13	9969	broad.mit.edu	37	17	60060325	60060325	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:60060325C>T	uc002izo.2	-	16	3116	c.3039G>A	c.(3037-3039)AGG>AGA	p.R1013R		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1013					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCCTTGGAGTCCTTGGAGTTG	0.502													15	46					0	0	0.003163	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60351221	60351221	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:60351221C>T	uc002izq.2	-	3	206	c.94G>A	c.(94-96)GAG>AAG	p.E32K	TBC1D3P2_uc010woz.1_RNA					SubName: Full=Putative uncharacterized protein TBC1D3E;												0						CCCTTGTCCTCTGGCAGCCCA	0.597													130	105					0	0	0.003610	0	0
RGS9	8787	broad.mit.edu	37	17	63156360	63156360	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:63156360A>G	uc002jfe.2	+	4	325	c.215A>G	c.(214-216)AAC>AGC	p.N72S	RGS9_uc010dem.2_Missense_Mutation_p.N72S|RGS9_uc002jfd.2_Missense_Mutation_p.N72S|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	72	DEP.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						GAGGCACAGAACTTGGGCAAC	0.527													48	37					0	0	0.003610	0	0
SLC9A3R1	9368	broad.mit.edu	37	17	72759590	72759590	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:72759590G>A	uc002jlo.2	+	3	911	c.688G>A	c.(688-690)GTG>ATG	p.V230M	SLC9A3R1_uc002jln.1_RNA|SLC9A3R1_uc002jlp.2_Missense_Mutation_p.V74M	NM_004252	NP_004243	O14745	NHRF1_HUMAN	sodium/hydrogen exchanger regulatory factor 1	230	PDZ 2.				apoptosis|bile acid secretion|glutathione transport|microvillus assembly|negative regulation of cell proliferation|negative regulation of ERK1 and ERK2 cascade|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|protein complex assembly|regulation of protein kinase activity|regulation of sodium:hydrogen antiporter activity|renal absorption|Wnt receptor signaling pathway	actin cytoskeleton|apical plasma membrane|centrosome|endomembrane system|filopodium|intracellular membrane-bounded organelle|microvillus membrane|ruffle	beta-2 adrenergic receptor binding|beta-catenin binding|chloride channel regulator activity|growth factor receptor binding|PDZ domain binding|phosphatase binding|protein self-association				0						CAAGCTGCTGGTGGTGGACAG	0.622													21	12					0	0	0.001523	0	0
TRIM65	201292	broad.mit.edu	37	17	73887946	73887946	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:73887946G>A	uc002jpx.2	-	5	969	c.933C>T	c.(931-933)CCC>CCT	p.P311P		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	311						intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCGGTGCCAGGGGACCTGGGG	0.532													5	18					0	0	0.001168	0	0
EVPL	2125	broad.mit.edu	37	17	74020174	74020174	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:74020174G>A	uc002jqi.2	-	2	354	c.126C>T	c.(124-126)CTC>CTT	p.L42L	EVPL_uc010wss.1_Silent_p.L42L|EVPL_uc010wst.1_5'UTR	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	42	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TGCGGGAGATGAGAAGGGCCA	0.672													12	25					0	0	0.004990	0	0
USP36	57602	broad.mit.edu	37	17	76799935	76799935	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:76799935G>A	uc002jvz.1	-	16	2667	c.2342C>T	c.(2341-2343)TCG>TTG	p.S781L	USP36_uc002jwa.1_Missense_Mutation_p.S781L|USP36_uc002jwb.1_Missense_Mutation_p.S393L|USP36_uc002jwc.1_Missense_Mutation_p.S481L|USP36_uc002jvy.1_5'Flank	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	781					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CAGCGCCGTCGAGATGGAGGA	0.637													65	53					0	0	0.003610	0	0
GAA	2548	broad.mit.edu	37	17	78078786	78078786	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:78078786C>T	uc002jxo.2	+	3	583	c.401C>T	c.(400-402)CCC>CTC	p.P134L	GAA_uc002jxp.2_Missense_Mutation_p.P134L|GAA_uc002jxq.2_Missense_Mutation_p.P134L	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	134					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	CCCAGCTACCCCAGCTACAAG	0.632													5	19					0	0	0.000602	0	0
GAA	2548	broad.mit.edu	37	17	78090819	78090819	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:78090819G>A	uc002jxo.2	+	17	2424	c.2242G>A	c.(2242-2244)GAG>AAG	p.E748K	GAA_uc002jxp.2_Missense_Mutation_p.E748K|GAA_uc002jxq.2_Missense_Mutation_p.E748K	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	748					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	CCTGTGGGGGGAGGCCCTGCT	0.632													11	50					0	0	0.001368	0	0
BAHCC1	57597	broad.mit.edu	37	17	79429066	79429066	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr17:79429066C>T	uc002kaf.2	+	24	7377	c.7377C>T	c.(7375-7377)CCC>CCT	p.P2459P	BAHCC1_uc002kae.2_Silent_p.P1689P	NM_001080519	NP_001073988	Q9P281	BAHC1_HUMAN	BAH domain and coiled-coil containing 1	2459							DNA binding			ovary(1)	1	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0224)|OV - Ovarian serous cystadenocarcinoma(97;0.116)			CGGGGAATCCCACACAGGTAG	0.662													15	24					0	0	0.004007	0	0
LAMA3	3909	broad.mit.edu	37	18	21396405	21396405	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:21396405G>A	uc002kuq.2	+	18	2187	c.2101G>A	c.(2101-2103)GGA>AGA	p.G701R	LAMA3_uc002kur.2_Missense_Mutation_p.G701R	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	701	Domain V.|Laminin EGF-like 8.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGCCCTCGGGAGTGTGCCA	0.547													22	25					0	0	0.002780	0	0
CDH2	1000	broad.mit.edu	37	18	25573486	25573486	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:25573486G>A	uc002kwg.2	-	8	1595	c.1136C>T	c.(1135-1137)CCT>CTT	p.P379L	CDH2_uc010xbn.1_Missense_Mutation_p.P348L	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	379	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						AAACTCTGGAGGATTGTCATT	0.448													129	119					0	0	0.003610	0	0
DSC3	1825	broad.mit.edu	37	18	28610971	28610971	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:28610971C>T	uc002kwj.3	-	3	477	c.322G>A	c.(322-324)GAG>AAG	p.E108K	DSC3_uc002kwi.3_Missense_Mutation_p.E108K	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	108					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ACAGTAACCTCTTTCTGTGTC	0.343													23	32					0	0	0.008361	0	0
DSG4	147409	broad.mit.edu	37	18	28989470	28989470	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:28989470G>A	uc002kwq.2	+	13	2124	c.1989G>A	c.(1987-1989)CTG>CTA	p.L663L	DSG4_uc002kwr.2_Silent_p.L663L	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	663	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGAAGGCCTGGGAACAAGAT	0.542													40	90					0	0	0.006230	0	0
C18orf34	374864	broad.mit.edu	37	18	30913285	30913285	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:30913285A>G	uc002kxn.2	-	9	874	c.732T>C	c.(730-732)CAT>CAC	p.H244H	C18orf34_uc010xbr.1_Silent_p.H244H|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Silent_p.H244H|C18orf34_uc002kxp.2_Silent_p.H244H	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	244	Potential.									ovary(1)	1						GTTTTTCAAAATGTTGTAGTT	0.348													23	45					0	0	0.002780	0	0
ASXL3	80816	broad.mit.edu	37	18	31326518	31326518	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:31326518G>A	uc010dmg.1	+	12	6761	c.6706G>A	c.(6706-6708)GGT>AGT	p.G2236S	ASXL3_uc002kxq.2_Missense_Mutation_p.G1943S	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2236	PHD-type; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						CGACTGCATAGGTCCTTCAAA	0.478													51	33					0	0	0.003610	0	0
SYT4	6860	broad.mit.edu	37	18	40850574	40850574	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:40850574C>T	uc002law.2	-	4	1379	c.1010G>A	c.(1009-1011)AGA>AAA	p.R337K	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.R319K|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	337	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CTTGGAGATTCTCTTTTTGGC	0.428													26	31					0	0	0.002096	0	0
ZBTB7C	201501	broad.mit.edu	37	18	45566986	45566986	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:45566986C>T	uc002lda.2	-	1	509	c.493G>A	c.(493-495)GAT>AAT	p.D165N	ZBTB7C_uc002ldb.2_Missense_Mutation_p.D165N|ZBTB7C_uc010dnu.2_Missense_Mutation_p.D174N|ZBTB7C_uc010dnv.2_Missense_Mutation_p.D187N|ZBTB7C_uc010dnw.2_Missense_Mutation_p.D165N|ZBTB7C_uc010dnx.1_Missense_Mutation_p.D165N|ZBTB7C_uc010dny.1_Missense_Mutation_p.D165N|ZBTB7C_uc010dnz.1_Missense_Mutation_p.D187N|ZBTB7C_uc010dob.1_Missense_Mutation_p.D165N|ZBTB7C_uc010doc.1_Missense_Mutation_p.D174N|ZBTB7C_uc010dod.1_Missense_Mutation_p.D187N|ZBTB7C_uc010doe.1_Missense_Mutation_p.D165N|ZBTB7C_uc010dof.1_Missense_Mutation_p.D165N|ZBTB7C_uc010dog.1_Missense_Mutation_p.D165N|ZBTB7C_uc010doh.1_Missense_Mutation_p.D174N|ZBTB7C_uc010doi.1_Missense_Mutation_p.D165N|ZBTB7C_uc010doj.1_Missense_Mutation_p.D174N|ZBTB7C_uc010dok.1_Missense_Mutation_p.D214N|ZBTB7C_uc010dol.1_Missense_Mutation_p.D174N|ZBTB7C_uc010doa.1_Missense_Mutation_p.D187N|ZBTB7C_uc010don.1_Missense_Mutation_p.D173N|ZBTB7C_uc010doo.1_Missense_Mutation_p.D165N|ZBTB7C_uc010dop.1_Missense_Mutation_p.D165N|ZBTB7C_uc010doq.1_Missense_Mutation_p.D174N|ZBTB7C_uc010dor.1_Missense_Mutation_p.D187N|ZBTB7C_uc010dos.1_Missense_Mutation_p.D165N|ZBTB7C_uc010dot.1_Missense_Mutation_p.D165N|ZBTB7C_uc010dou.1_Missense_Mutation_p.D174N|ZBTB7C_uc010dom.1_Missense_Mutation_p.D174N	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	165	Asp-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GTGTCATCATCGTCAtcctcc	0.274													21	62					0	0	0.002299	0	0
MYO5B	4645	broad.mit.edu	37	18	47506853	47506853	+	Silent	SNP	C	T	T	rs139934455	by1000genomes	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:47506853C>T	uc002leb.2	-	9	1305	c.1017G>A	c.(1015-1017)GCG>GCA	p.A339A	MYO5B_uc002lec.1_Silent_p.A338A	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	339	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		CAGCCTGAATCGCCACACTTC	0.403													10	28					0	0	0.000978	0	0
MEX3C	51320	broad.mit.edu	37	18	48703834	48703835	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:48703834_48703835GG>AA	uc002lfc.3	-	2	866_867	c.866_867CC>TT	c.(865-867)GCC>GTT	p.A289V		NM_016626	NP_057710	Q5U5Q3	MEX3C_HUMAN	ring finger and KH domain containing 2	289	KH 1.					cytoplasm|nucleus	RNA binding|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		Colorectal(6;0.003)|all_epithelial(6;0.0473)		Colorectal(16;0.0175)|READ - Rectum adenocarcinoma(32;0.15)		TCTCTCTTTTGGCCATGGCAAC	0.465													19	55					0	0	0.004672	0	0
DCC	1630	broad.mit.edu	37	18	50961561	50961561	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:50961561G>A	uc002lfe.1	+	22	3798	c.3211G>A	c.(3211-3213)GAT>AAT	p.D1071N	DCC_uc010dpf.1_Missense_Mutation_p.D706N	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	1071	Extracellular (Potential).				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TAATTTGATTGATAGAAGCAC	0.328													113	116					0	0	0.003610	0	0
CCDC102B	79839	broad.mit.edu	37	18	66542000	66542000	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:66542000T>G	uc002lkk.2	+	7	1254	c.1031T>G	c.(1030-1032)GTG>GGG	p.V344G	CCDC102B_uc002lki.2_Missense_Mutation_p.V344G|CCDC102B_uc002lkj.1_Missense_Mutation_p.V344G	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	344										ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AAAGACAGAGTGATTTGTGAG	0.338													27	16					0	0	0.001786	0	0
CTDP1	9150	broad.mit.edu	37	18	77474843	77474843	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr18:77474843C>T	uc002lnh.1	+	8	1530	c.1383C>T	c.(1381-1383)AGC>AGT	p.S461S	CTDP1_uc002lni.1_Silent_p.S461S|CTDP1_uc010drd.1_Silent_p.S461S	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	461	Ser-rich.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		GCGAGAGCAGCAGTGAGTCCG	0.677													10	7					0	0	0.008291	0	0
MIER2	54531	broad.mit.edu	37	19	326591	326591	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:326591G>A	uc002lok.1	-	6	510	c.501C>T	c.(499-501)TTC>TTT	p.F167F		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	167					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CATCAGCCAGGAAACGAGCTT	0.557													31	47					0	0	0.007291	0	0
ATP8B3	148229	broad.mit.edu	37	19	1783186	1783186	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:1783186G>A	uc002ltw.2	-	29	3978	c.3744C>T	c.(3742-3744)CGC>CGT	p.R1248R	ATP8B3_uc002ltv.2_Silent_p.R1211R|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1248	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTGGAACGGCGGGCACGAG	0.582													5	17					0	0	0.000602	0	0
ZNF556	80032	broad.mit.edu	37	19	2877606	2877606	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:2877606C>T	uc002lwp.1	+	4	737	c.650C>T	c.(649-651)TCT>TTT	p.S217F	ZNF556_uc002lwq.2_Missense_Mutation_p.S216F	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	217	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGTTCCCACTCTCTCACTGAA	0.498													44	18					0	0	0.002222	0	0
APBA3	9546	broad.mit.edu	37	19	3759875	3759875	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:3759875C>T	uc002lyp.1	-	2	565	c.388G>A	c.(388-390)GAG>AAG	p.E130K	MRPL54_uc002lyq.3_5'Flank	NM_004886	NP_004877	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding,	130					intracellular signal transduction|protein transport	intracellular|membrane	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTAGAGGCTCTTCAGGACCA	0.647													22	79					0	0	0.003954	0	0
ZFR2	23217	broad.mit.edu	37	19	3834962	3834962	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:3834962G>A	uc002lyw.2	-	2	85	c.73C>T	c.(73-75)CCC>TCC	p.P25S	ZFR2_uc010xhx.1_RNA	NM_015174	NP_055989	Q9UPR6	ZFR2_HUMAN	zinc finger RNA binding protein 2 isoform 1	25						intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00514)|STAD - Stomach adenocarcinoma(1328;0.19)		GTGGGCAGGGGAAGGGTCGGA	0.627													5	17					0	0	0.000602	0	0
EEF2	1938	broad.mit.edu	37	19	3982420	3982420	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:3982420G>A	uc002lze.2	-	5	698	c.615C>T	c.(613-615)ATC>ATT	p.I205I		NM_001961	NP_001952	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	205						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACAGGATCGATCTGGAAGT	0.632													41	48					0	0	0.002222	0	0
CREB3L3	84699	broad.mit.edu	37	19	4171723	4171723	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:4171723C>T	uc002lzl.2	+	10	1259	c.1143C>T	c.(1141-1143)GCC>GCT	p.A381A	CREB3L3_uc002lzm.2_Silent_p.A371A|CREB3L3_uc010xib.1_Silent_p.A370A|CREB3L3_uc010xic.1_3'UTR	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	381	Lumenal (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTCCGAGGCCCCAGGACCCC	0.637													37	117					0	0	0.006230	0	0
ANKRD24	170961	broad.mit.edu	37	19	4219741	4219741	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:4219741G>A	uc010dtt.1	+	19	3433	c.3157G>A	c.(3157-3159)GAG>AAG	p.E1053K		NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1053	Potential.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		CAAGGCCAAGGAGAAGGACAA	0.582													20	44					0	0	0.008871	0	0
FEM1A	55527	broad.mit.edu	37	19	4793180	4793180	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:4793180C>T	uc002mbf.2	+	1	1453	c.1314C>T	c.(1312-1314)TTC>TTT	p.F438F	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	438					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TCCTCTCCTTCGCGGAACTCT	0.612													64	129					0	0	0.003610	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7518552	7518552	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:7518552C>T	uc002mgi.2	+	7	1744	c.1491C>T	c.(1489-1491)CTC>CTT	p.L497L	ARHGEF18_uc010xjm.1_Silent_p.L339L|ARHGEF18_uc002mgh.2_Silent_p.L339L|ARHGEF18_uc002mgj.1_Silent_p.L140L	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	497	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				AGCGGCAGCTCCACCTGGAGG	0.582													17	79					0	0	0.008871	0	0
STXBP2	6813	broad.mit.edu	37	19	7707104	7707104	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:7707104C>T	uc002mha.3	+	9	724	c.679C>T	c.(679-681)CGC>TGC	p.R227C	STXBP2_uc002mhb.3_Missense_Mutation_p.R224C|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.R238C|STXBP2_uc010dvk.2_Missense_Mutation_p.R195C|STXBP2_uc002mhc.3_5'UTR|STXBP2_uc002mhe.1_5'Flank	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	227					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						AGAGAAAACCCGCTCCCAGCT	0.632													17	55					0	0	0.004990	0	0
COL5A3	50509	broad.mit.edu	37	19	10107173	10107173	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:10107173G>A	uc002mmq.1	-	13	1444	c.1358C>T	c.(1357-1359)TCC>TTC	p.S453F		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	453	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GCCTTTAAAGGAGCCGCCTGC	0.617													8	31					0	0	0.003080	0	0
DOCK6	57572	broad.mit.edu	37	19	11352739	11352739	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:11352739G>A	uc002mqs.3	-	14	1666	c.1625C>T	c.(1624-1626)GCC>GTC	p.A542V		NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	542					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GGTATGGGGGGCATAGACTTC	0.612													15	10					0	0	0.008871	0	0
RNASEH2A	10535	broad.mit.edu	37	19	12918083	12918083	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:12918083T>G	uc002mvg.1	+	3	323	c.263T>G	c.(262-264)TTT>TGT	p.F88C	RNASEH2A_uc002mvf.1_Missense_Mutation_p.F6C	NM_006397	NP_006388	O75792	RNH2A_HUMAN	ribonuclease H2, large subunit	88					DNA replication|RNA catabolic process	nucleus|ribonuclease H2 complex	metal ion binding|ribonuclease H activity|RNA binding			breast(2)|central_nervous_system(1)	3						GACACGGACTTTGTCGGCTGG	0.597													48	126					0	0	0.003610	0	0
MAST1	22983	broad.mit.edu	37	19	12975980	12975980	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:12975980C>T	uc002mvm.2	+	14	1754	c.1626C>T	c.(1624-1626)TTC>TTT	p.F542F		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	542	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CCCGAGAGTTCCTGGACAAAC	0.607													17	43					0	0	0.001882	0	0
NANOS3	342977	broad.mit.edu	37	19	13988138	13988138	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:13988138C>T	uc002mxj.3	+	1	189	c.76C>T	c.(76-78)CCT>TCT	p.P26S		NM_001098622	NP_001092092	P60323	NANO3_HUMAN	nanos homolog 3	26					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			GAAAGAGGGTCCTGAAACCAG	0.642													86	61					0	0	0.003610	0	0
BRD4	23476	broad.mit.edu	37	19	15350537	15350537	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:15350537G>A	uc002nar.2	-	16	3600	c.3378C>T	c.(3376-3378)AGC>AGT	p.S1126S		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	1126					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GCAGCGAGGGGCTGAAGGGCT	0.697			T	NUT|C15orf55	lethal midline carcinoma of young people								19	54					0	0	0.007413	0	0
CYP4F2	8529	broad.mit.edu	37	19	15997107	15997107	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:15997107C>T	uc002nbs.1	-	8	980	c.930G>A	c.(928-930)GGG>GGA	p.G310G	CYP4F2_uc010xot.1_Silent_p.G161G|CYP4F2_uc010xou.1_Intron	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	310					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						ATAACTTCTTCCCGTCTTCAT	0.532													62	178					0	0	0.003610	0	0
NWD1	284434	broad.mit.edu	37	19	16899909	16899909	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:16899909G>A	uc002neu.3	+	13	3270	c.2848G>A	c.(2848-2850)GAT>AAT	p.D950N	NWD1_uc002net.3_Missense_Mutation_p.D815N|NWD1_uc002nev.3_Missense_Mutation_p.D744N			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	950							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TACCATTTGGGATGGAGGCTC	0.458													26	51					0	0	0.003330	0	0
MYO9B	4650	broad.mit.edu	37	19	17306107	17306107	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:17306107C>T	uc010eak.2	+	22	4023	c.3871C>T	c.(3871-3873)CCC>TCC	p.P1291S	MYO9B_uc002nfi.2_Missense_Mutation_p.P1291S|MYO9B_uc002nfj.1_Missense_Mutation_p.P1291S|MYO9B_uc002nfl.1_5'Flank	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	myosin IXB isoform 1	1291	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(1)	1						GCCCGACAGCCCCGGAGGCTC	0.711													28	35					0	0	0.008361	0	0
PLVAP	83483	broad.mit.edu	37	19	17476972	17476972	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:17476972A>G	uc002ngk.1	-	2	452	c.402T>C	c.(400-402)GCT>GCC	p.A134A		NM_031310	NP_112600	Q9BX97	PLVAP_HUMAN	plasmalemma vesicle associated protein	134	Extracellular (Potential).					caveola|integral to membrane|perinuclear region of cytoplasm					0						AGATGATGGCAGCCATGTACC	0.552													51	144					0	0	0.003610	0	0
UNC13A	23025	broad.mit.edu	37	19	17783262	17783262	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:17783262C>T	uc002nhd.2	-	5	459	c.459G>A	c.(457-459)TGG>TGA	p.W153*		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	65	C2 1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						GACCCTTATTCCACACCTCCA	0.537													24	25					0	0	0.006320	0	0
SF4	57794	broad.mit.edu	37	19	19408023	19408023	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:19408023G>A	uc002nmh.2	-	8	1020	c.1018C>T	c.(1018-1020)CCT>TCT	p.P340S	SF4_uc002nmf.2_5'UTR|SF4_uc002nmg.2_5'UTR|SF4_uc002nmi.2_Missense_Mutation_p.P130S|SF4_uc002nmj.2_Missense_Mutation_p.P130S|SF4_uc010xqr.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	340	Pro-rich.				nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						AGGGCCTCAGGAGGGGACTTG	0.657													54	52					0	0	0.003610	0	0
ZNF676	163223	broad.mit.edu	37	19	22363414	22363414	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:22363414C>T	uc002nqs.1	-	3	1423	c.1105G>A	c.(1105-1107)GGA>AGA	p.G369R		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	369	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTGCCACATCCTTCACATTTG	0.393													19	48					0	0	0.007413	0	0
ZNF99	7652	broad.mit.edu	37	19	22939518	22939519	+	Missense_Mutation	DNP	CC	TA	TA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:22939518_22939519CC>TA	uc010xrh.1	-	7	2652_2653	c.2652_2653GG>TA	c.(2650-2655)GGGGAG>GGTAAG	p.E885K		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TACGGTTTCTCCCCAGTATGAA	0.351													14	41					0	0	0.004672	0	0
ZNF99	7652	broad.mit.edu	37	19	22940616	22940616	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:22940616G>A	uc010xrh.1	-	5	1822	c.1822C>T	c.(1822-1824)CAT>TAT	p.H608Y		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTCCAGTATGAATTATCTTA	0.363													11	31					0	0	0.008291	0	0
WTIP	126374	broad.mit.edu	37	19	34983992	34983992	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:34983992T>G	uc002nvm.2	+	3	820	c.820T>G	c.(820-822)TGC>GGC	p.C274G		NM_001080436	NP_001073905			Wilms tumor 1 interacting protein												0	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			GAAAGTGTACTGCCAGGAGGA	0.627													52	59					0	0	0.003610	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35512625	35512625	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:35512625C>T	uc010xse.1	+	15	1747	c.1610C>T	c.(1609-1611)TCT>TTT	p.S537F	GRAMD1A_uc002nxk.2_Missense_Mutation_p.S530F|GRAMD1A_uc002nxl.2_Missense_Mutation_p.S303F|GRAMD1A_uc010xsf.1_Missense_Mutation_p.S542F|GRAMD1A_uc002nxm.1_RNA|GRAMD1A_uc002nxn.1_Missense_Mutation_p.S152F	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A isoform 1	537						integral to membrane					0	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GAGAAGCTGTCTCTGGAGGAA	0.697													32	45					0	0	0.003755	0	0
HNRNPL	3191	broad.mit.edu	37	19	39334494	39334494	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:39334494G>A	uc010xul.1	-	6	879	c.868C>T	c.(868-870)CTC>TTC	p.L290F	HNRNPL_uc002ojk.2_5'Flank|HNRNPL_uc002ojl.2_5'Flank|HNRNPL_uc010xum.1_Missense_Mutation_p.L157F|HNRNPL_uc010xun.1_5'UTR	NM_001533	NP_001524	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	290					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding				0	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			TGTCCACTGAGATTGGGGTTT	0.473													49	38					0	0	0.003610	0	0
PAPL	390928	broad.mit.edu	37	19	39597640	39597640	+	Silent	SNP	C	T	T	rs142073546		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:39597640C>T	uc002oki.2	+	12	1441	c.1167C>T	c.(1165-1167)GCC>GCT	p.A389A	PAPL_uc010egl.2_Intron	NM_001004318	NP_001004318	Q6ZNF0	PAPL_HUMAN	iron/zinc purple acid phosphatase-like protein	389						extracellular region	acid phosphatase activity|metal ion binding				0						CCTGGAGTGCCGTGCGTGTGA	0.652													6	35					0	0	0.001984	0	0
FCGBP	8857	broad.mit.edu	37	19	40360893	40360893	+	Missense_Mutation	SNP	T	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:40360893T>G	uc002omp.3	-	33	15523	c.15515A>C	c.(15514-15516)CAA>CCA	p.Q5172P		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5172	Cys-rich.|TIL 12.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCCACAATCTTGGACAGGGAT	0.607													21	49					0	0	0.001523	0	0
PSMC4	5704	broad.mit.edu	37	19	40486287	40486287	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:40486287G>A	uc002omq.2	+	9	1050	c.1013G>A	c.(1012-1014)CGC>CAC	p.R338H	PSMC4_uc002omr.2_Missense_Mutation_p.R307H	NM_006503	NP_006494	P43686	PRS6B_HUMAN	proteasome 26S ATPase subunit 4 isoform 1	338					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			ovary(1)	1	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CTTCCTGACCGCCGCCAGAAG	0.522													56	151					0	0	0.003610	0	0
HIPK4	147746	broad.mit.edu	37	19	40886829	40886829	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:40886829C>T	uc002onp.2	-	3	1354	c.1069G>A	c.(1069-1071)GAG>AAG	p.E357K		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	357						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TGGGTGGTCTCGTGGGCACTG	0.662													32	74					0	0	0.002836	0	0
SERTAD1	29950	broad.mit.edu	37	19	40929200	40929200	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:40929200G>A	uc002ont.3	-	2	413	c.254C>T	c.(253-255)GCT>GTT	p.A85V		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	85	SERTA.				positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGCAGGGCAGCCGCGGGTGC	0.667													7	15					0	0	0.004482	0	0
SPTBN4	57731	broad.mit.edu	37	19	41062007	41062007	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:41062007G>A	uc002ony.2	+	25	5188	c.5102G>A	c.(5101-5103)CGG>CAG	p.R1701Q	SPTBN4_uc002onx.2_Missense_Mutation_p.R1701Q|SPTBN4_uc002onz.2_Missense_Mutation_p.R1701Q|SPTBN4_uc010egx.2_Missense_Mutation_p.R444Q|SPTBN4_uc002ooa.2_Missense_Mutation_p.R377Q	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1701	Spectrin 14.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ATCAGCCGGCGGCAGTCTCAG	0.667													20	14					0	0	0.007413	0	0
PSG1	5669	broad.mit.edu	37	19	43343479	43343479	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:43343479C>T	uc002our.1	-	6	1433	c.1295G>A	c.(1294-1296)TGA>TAA	p.*432*	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Silent_p.*345*|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Silent_p.*158*|PSG10_uc002ouv.1_Intron|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Intron|PSG10_uc010eip.2_RNA|PSG1_uc010eio.1_Intron	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	432					female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GAAATGACATCACCGCTGCTC	0.443													11	36					0	0	0.001368	0	0
ZNF222	7673	broad.mit.edu	37	19	44537123	44537123	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:44537123G>A	uc002oyc.2	+	4	1479	c.1296G>A	c.(1294-1296)AAG>AAA	p.K432K	ZNF284_uc010ejd.2_Intron|ZNF222_uc002oye.2_Silent_p.K472K|ZNF222_uc002oyd.2_Silent_p.K378K	NM_013360	NP_037492	Q9UK12	ZN222_HUMAN	zinc finger protein 222 isoform 2	432					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Prostate(69;0.0435)				ACTGTGGGAAGCGCTACAAGA	0.313													9	35					0	0	0.004482	0	0
ZNF226	7769	broad.mit.edu	37	19	44680330	44680330	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:44680330A>G	uc002oyp.2	+	6	1059	c.915A>G	c.(913-915)GAA>GAG	p.E305E	ZNF226_uc002oyq.2_Silent_p.E188E|ZNF226_uc002oyr.2_Silent_p.E188E|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Silent_p.E305E|ZNF226_uc002oyt.2_Silent_p.E305E	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				ATGTGGGAGAAAAACTTAAGT	0.433													14	35					0	0	0.003163	0	0
ZNF226	7769	broad.mit.edu	37	19	44680334	44680334	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:44680334C>A	uc002oyp.2	+	6	1063	c.919C>A	c.(919-921)CTT>ATT	p.L307I	ZNF226_uc002oyq.2_Missense_Mutation_p.L190I|ZNF226_uc002oyr.2_Missense_Mutation_p.L190I|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.L307I|ZNF226_uc002oyt.2_Missense_Mutation_p.L307I	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	307	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				GGGAGAAAAACTTAAGTGTGA	0.433													12	36					7.93312e-07	1.20511e-06	0.002450	1	0
CYTH2	9266	broad.mit.edu	37	19	48977503	48977504	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:48977503_48977504CC>TT	uc002pjj.3	+	7	912_913	c.612_613CC>TT	c.(610-615)GTCCGG>GTTTGG	p.R205W	CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	205					actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						ATCCCAATGTCCGGGACAAGCC	0.634													36	50					0	0	0.004672	0	0
SCAF1	58506	broad.mit.edu	37	19	50158054	50158054	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:50158054C>T	uc002poq.2	+	9	3669	c.3545C>T	c.(3544-3546)CCC>CTC	p.P1182L		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1182					mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CCCCCCACCCCCACCGGGCTG	0.697													32	22					0	0	0.001786	0	0
MYH14	79784	broad.mit.edu	37	19	50775127	50775127	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:50775127C>T	uc002prr.1	+	24	3117	c.3070C>T	c.(3070-3072)CGT>TGT	p.R1024C	MYH14_uc010enu.1_Missense_Mutation_p.R1065C|MYH14_uc002prq.1_Missense_Mutation_p.R1032C	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	1024	Potential.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GCTGGAAGATCGTCTGGCCGA	0.582													4	17					0	0	0.000602	0	0
SYT3	84258	broad.mit.edu	37	19	51133395	51133395	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:51133395C>T	uc002pst.2	-	3	1342	c.708G>A	c.(706-708)CAG>CAA	p.Q236Q	SYT3_uc002psv.2_Silent_p.Q236Q|SYT3_uc010ycd.1_Silent_p.Q236Q	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	236	Cytoplasmic (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		AGGTCAGAGTCTGCTGGGTGA	0.642													18	18					0	0	0.004990	0	0
FPR3	2359	broad.mit.edu	37	19	52327535	52327535	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:52327535C>T	uc002pxt.1	+	2	718	c.534C>T	c.(532-534)TTC>TTT	p.F178F		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	178	Extracellular (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						ACTGTATTTTCAACTTTGCAT	0.433													51	72					0	0	0.003610	0	0
ZNF616	90317	broad.mit.edu	37	19	52618800	52618800	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:52618800A>G	uc002pym.2	-	4	1900	c.1617T>C	c.(1615-1617)CAT>CAC	p.H539H	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	539	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		GAATTCTCCGATGCCTTGCAA	0.443													38	38					0	0	0.004878	0	0
ZNF665	79788	broad.mit.edu	37	19	53669139	53669139	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:53669139C>T	uc010eqm.1	-	4	704	c.604G>A	c.(604-606)GGA>AGA	p.G202R		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		GGCTTCTCTCCAGTATGAATT	0.388													66	54					0	0	0.003610	0	0
VN1R2	317701	broad.mit.edu	37	19	53762553	53762553	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:53762553C>T	uc002qbi.2	+	1	1009	c.925C>T	c.(925-927)CCT>TCT	p.P309S		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	309	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		CAACTCTTCTCCTGGGAACAG	0.483													40	111					0	0	0.006230	0	0
ZNF845	91664	broad.mit.edu	37	19	53855689	53855689	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:53855689C>T	uc010ydv.1	+	4	1878	c.1761C>T	c.(1759-1761)GTC>GTT	p.V587V	ZNF845_uc010ydw.1_Silent_p.V587V	NM_138374	NP_612383	Q96IR2	ZN845_HUMAN	zinc finger protein 845	587	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTCACCAAGTCTTTAGTAATG	0.378													7	14					0	0	0.001984	0	0
NLRP12	91662	broad.mit.edu	37	19	54313652	54313652	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:54313652C>T	uc002qch.3	-	3	1481	c.1261G>A	c.(1261-1263)GGG>AGG	p.G421R	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.G421R|NLRP12_uc002qcj.3_Missense_Mutation_p.G421R|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.G421R	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	421	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AACAGCCCCCCACCCTCCAGC	0.622													81	84					0	0	0.003610	0	0
LILRB2	10288	broad.mit.edu	37	19	54782907	54782907	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:54782907C>T	uc002qfb.2	-	6	981	c.715G>A	c.(715-717)GAA>AAA	p.E239K	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.E239K|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.E239K|LILRB2_uc010yet.1_Missense_Mutation_p.E123K|LILRB2_uc010yeu.1_Intron	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	239	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTCAGGCTTTCCCCAGGGGCC	0.592													19	70					0	0	0.001523	0	0
LILRA3	11026	broad.mit.edu	37	19	54803632	54803632	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:54803632C>T	uc002qfd.2	-	3	257	c.192G>A	c.(190-192)AAG>AAA	p.K64K	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.K64K	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	64	Ig-like C2-type 1.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTGCTGTTTTCTTTTCTCTAT	0.547													58	53					0	0	0.003610	0	0
LILRA1	11024	broad.mit.edu	37	19	55106864	55106864	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:55106864C>T	uc002qgh.1	+	5	840	c.658C>T	c.(658-660)CTA>TTA	p.L220L	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Silent_p.L220L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	220	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GCTCCTGGTCCTAGGTGAGAA	0.587													20	97					0	0	0.001523	0	0
LILRP2	79166	broad.mit.edu	37	19	55221995	55221995	+	RNA	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:55221995C>T	uc002qgs.1	+	1		c.2395C>T			LILRP2_uc002qgt.1_RNA	NR_003061				Homo sapiens leukocyte immunoglobulin-like receptor pseudogene 2 (LILRP2), non-coding RNA.												0						TGGACACTTTCCTTCTGACCA	0.622													15	39					0	0	0.002450	0	0
KIR2DS4	3809	broad.mit.edu	37	19	55354367	55354367	+	Missense_Mutation	SNP	A	G	G	rs1130508		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:55354367A>G	uc002qhm.1	+	6	755	c.709A>G	c.(709-711)AAA>GAA	p.K237E	KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Intron|KIR2DS4_uc002qhn.1_Intron	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	237	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		ACCAAGCTCCAAAACCGGTGA	0.507													5	79					0	0	0.000602	0	0
NLRP2	55655	broad.mit.edu	37	19	55508784	55508784	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:55508784C>T	uc002qij.2	+	12	3065	c.2979C>T	c.(2977-2979)CCC>CCT	p.P993P	NLRP2_uc010yfp.1_Silent_p.P970P|NLRP2_uc010esn.2_Silent_p.P969P|NLRP2_uc010eso.2_Silent_p.P990P|NLRP2_uc010esp.2_Silent_p.P971P	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	993	LRR 7.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GTCAGAATCCCTTGGGGTCTA	0.542													94	73					0	0	0.003610	0	0
HSPBP1	23640	broad.mit.edu	37	19	55776708	55776708	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:55776708G>A	uc002qjx.2	-	6	1191	c.1081C>T	c.(1081-1083)CTG>TTG	p.L361L	HSPBP1_uc002qjy.2_Silent_p.L315L|HSPBP1_uc002qkb.2_Missense_Mutation_p.T311I|HSPBP1_uc002qka.2_Silent_p.L315L|HSPBP1_uc002qkd.2_Silent_p.L315L|HSPBP1_uc002qkc.2_Silent_p.L315L|uc002qke.2_5'Flank	NM_012267	NP_036399	Q9NZL4	HPBP1_HUMAN	hsp70-interacting protein	318					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		TCCAGGCCCAGTTCCGGCTCC	0.647													32	101					0	0	0.003755	0	0
NLRP4	147945	broad.mit.edu	37	19	56369277	56369277	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:56369277C>G	uc002qmd.3	+	3	940	c.518C>G	c.(517-519)TCG>TGG	p.S173W	NLRP4_uc002qmf.2_Missense_Mutation_p.S98W|NLRP4_uc010etf.2_Missense_Mutation_p.S4W	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	173	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ATGGCCTGGTCGGACAACAAG	0.498													71	67					0	0	0.003610	0	0
NLRP5	126206	broad.mit.edu	37	19	56539572	56539572	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:56539572C>T	uc002qmj.2	+	7	1973	c.1973C>T	c.(1972-1974)CCC>CTC	p.P658L	NLRP5_uc002qmi.2_Missense_Mutation_p.P639L	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	658						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGTCCCGTTCCCCTGGGGGTG	0.587													51	47					0	0	0.003610	0	0
ZNF749	388567	broad.mit.edu	37	19	57956042	57956043	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:57956042_57956043GG>AA	uc002qoq.2	+	3	1780_1781	c.1526_1527GG>AA	c.(1525-1527)CGG>CAA	p.R509Q	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	509					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		ACTGGAGAACGGCCTTATGAAT	0.455													42	33					0	0	0.004672	0	0
ZNF544	27300	broad.mit.edu	37	19	58772459	58772460	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr19:58772459_58772460GG>AA	uc010euo.2	+	7	961_962	c.487_488GG>AA	c.(487-489)GGA>AAA	p.G163K	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.G135K|ZNF544_uc010yhy.1_Missense_Mutation_p.G135K|ZNF544_uc002qrt.3_Missense_Mutation_p.G21K|ZNF544_uc002qru.3_Missense_Mutation_p.G21K|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TGAACTTGGGGGAGGTTATTCT	0.436													10	48					0	0	0.004672	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698408	17698408	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:17698408T>A	uc002rcl.1	-	1	1299	c.1275A>T	c.(1273-1275)AAA>AAT	p.K425N	RAD51AP2_uc010exn.1_Missense_Mutation_p.K416N	NM_001099218	NP_001092688	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	425										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTTCTTCAGTTTTTTTCATAT	0.294													18	39					0	0	0.004990	0	0
APOB	338	broad.mit.edu	37	2	21249788	21249788	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:21249788C>A	uc002red.2	-	15	2244	c.2116G>T	c.(2116-2118)GGG>TGG	p.G706W		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	706					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCTTGCTTCCCAAAAAGAGCT	0.423													7	382					0.000673444	0.00101373	0.008291	1	0
C2orf44	80304	broad.mit.edu	37	2	24260573	24260573	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:24260573G>A	uc002rep.2	-	2	1923	c.1792C>T	c.(1792-1794)CTT>TTT	p.L598F	C2orf44_uc010eya.2_Missense_Mutation_p.L598F	NM_025203	NP_079479	Q9H6R7	CB044_HUMAN	hypothetical protein LOC80304 isoform 1	598							protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACATAAGGAAGATCTTGAGAG	0.413													23	74					0	0	0.002780	0	0
SLC30A3	7781	broad.mit.edu	37	2	27481643	27481643	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:27481643G>A	uc002rjk.2	-	2	441	c.255C>T	c.(253-255)GTC>GTT	p.V85V	SLC30A3_uc002rjj.2_5'Flank|SLC30A3_uc010ylh.1_Silent_p.V80V	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	85	Helical; (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCCATGAAGACAAAGCAAA	0.607													11	97					0	0	0.001855	0	0
C2orf16	84226	broad.mit.edu	37	2	27802108	27802109	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:27802108_27802109CC>TT	uc002rkz.3	+	1	2720_2721	c.2669_2670CC>TT	c.(2668-2670)TCC>TTT	p.S890F		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	890										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AAATATCTCTCCACTATGCTAA	0.46													35	94					0	0	0.004672	0	0
EHD3	30845	broad.mit.edu	37	2	31457696	31457696	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:31457696G>A	uc002rnu.2	+	1	817	c.209G>A	c.(208-210)GGG>GAG	p.G70E	EHD3_uc010ymt.1_Missense_Mutation_p.G70E	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	70	ATP (By similarity).				blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					TACTCCACTGGGAAGACCACC	0.642													30	22					0	0	0.002096	0	0
EHD3	30845	broad.mit.edu	37	2	31483452	31483452	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:31483452A>T	uc002rnu.2	+	4	1187	c.579A>T	c.(577-579)AAA>AAT	p.K193N	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	193					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					ATGCCCACAAACTGGACATCT	0.537													18	58					0	0	0.006122	0	0
TTC7A	57217	broad.mit.edu	37	2	47249053	47249053	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:47249053C>T	uc002rvo.2	+	12	1813	c.1445C>T	c.(1444-1446)GCC>GTC	p.A482V	TTC7A_uc002rvm.2_Missense_Mutation_p.A448V|TTC7A_uc002rvn.1_Missense_Mutation_p.A363V|TTC7A_uc010fbb.2_Missense_Mutation_p.A482V|TTC7A_uc010fbc.2_Missense_Mutation_p.A128V|TTC7A_uc002rvp.2_Missense_Mutation_p.A363V|TTC7A_uc002rvq.2_Missense_Mutation_p.A222V|TTC7A_uc002rvr.2_Intron	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	482							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GGAGAGGAAGCCGGGGAGTTC	0.607													45	47					0	0	0.002852	0	0
MSH6	2956	broad.mit.edu	37	2	48027152	48027152	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:48027152G>T	uc002rwd.3	+	4	2182	c.2030G>T	c.(2029-2031)AGT>ATT	p.S677I	MSH6_uc002rwc.2_Missense_Mutation_p.S677I|MSH6_uc010fbj.2_Missense_Mutation_p.S375I|MSH6_uc010yoi.1_Missense_Mutation_p.S547I|MSH6_uc010yoj.1_Missense_Mutation_p.S375I	NM_000179	NP_000170	P52701	MSH6_HUMAN	mutS homolog 6	677					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding			large_intestine(53)|central_nervous_system(28)|endometrium(28)|stomach(22)|haematopoietic_and_lymphoid_tissue(9)|lung(7)|skin(6)|urinary_tract(5)|breast(5)|ovary(3)|thyroid(1)|upper_aerodigestive_tract(1)	168		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			GGAGAGAAAAGTGAATTGGCC	0.418			Mis|N|F|S		colorectal	colorectal|endometrial|ovarian		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				37	122					4.11147e-13	6.27441e-13	0.003755	1	0
NRXN1	9378	broad.mit.edu	37	2	51254796	51254796	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:51254796C>T	uc010fbq.2	-	2	2093	c.616G>A	c.(616-618)GAT>AAT	p.D206N	NRXN1_uc002rxe.3_Missense_Mutation_p.D206N|NRXN1_uc002rxd.1_Missense_Mutation_p.D206N	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGCGGCTCATCGTCCAGCTTC	0.697													9	5					0	0	0.008291	0	0
MTIF2	4528	broad.mit.edu	37	2	55467227	55467227	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:55467227T>A	uc002ryn.2	-	15	2527	c.1790A>T	c.(1789-1791)AAA>ATA	p.K597I	MTIF2_uc010yox.1_Missense_Mutation_p.K266I|MTIF2_uc002ryo.2_Missense_Mutation_p.K597I	NM_001005369	NP_001005369	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	597					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			ovary(1)	1						GTAAATTATTTTGTGAAGTTT	0.383													8	19					0	0	0.003080	0	0
C2orf78	388960	broad.mit.edu	37	2	74043308	74043308	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:74043308C>T	uc002sjr.1	+	3	2079	c.1958C>T	c.(1957-1959)TCC>TTC	p.S653F		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	653										ovary(2)	2						TTCTCTTCCTCCAGGACCCTG	0.512													35	31					0	0	0.003271	0	0
TACR1	6869	broad.mit.edu	37	2	75426023	75426023	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:75426023G>A	uc002sng.2	-	1	623	c.38C>T	c.(37-39)CCA>CTA	p.P13L	TACR1_uc002snh.2_Missense_Mutation_p.P13L	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	13	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	GGAGATGTTTGGGGAGAGGTC	0.542													10	29					0	0	0.008291	0	0
ANKRD20B	729171	broad.mit.edu	37	2	95481214	95481214	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:95481214G>A	uc010fhq.1	-	2	1166	c.774C>T	c.(772-774)TTC>TTT	p.F258F	ANKRD20B_uc010fhp.2_RNA	NM_001012421	NP_001012421			ankyrin repeat domain 20 family, member A2												0						TTGTCTTACGGAACTTATCTT	0.323													62	49					0	0	0.003610	0	0
C2orf55	343990	broad.mit.edu	37	2	99448906	99448906	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:99448906C>T	uc002szf.1	-	5	739	c.445G>A	c.(445-447)GAG>AAG	p.E149K		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	149											0						CCGGCATCCTCTCCCCGCTTG	0.552													58	39					0	0	0.003610	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459496	107459496	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:107459496T>A	uc002tdq.2	-	2	1057	c.938A>T	c.(937-939)GAA>GTA	p.E313V	ST6GAL2_uc002tdr.2_Missense_Mutation_p.E313V|ST6GAL2_uc002tds.3_Missense_Mutation_p.E313V	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	313	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CCTACCTATTTCCTCGCCCAA	0.667													4	11					0	0	0.001168	0	0
EDAR	10913	broad.mit.edu	37	2	109526934	109526934	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:109526934G>A	uc002teq.3	-	9	1216	c.785C>T	c.(784-786)CCA>CTA	p.P262L	EDAR_uc010fjn.2_Missense_Mutation_p.P294L|EDAR_uc010yws.1_Missense_Mutation_p.P294L	NM_022336	NP_071731	Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor precursor	262	Cytoplasmic (Potential).			P -> S (in Ref. 1; AAD50077).	apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			skin(1)	1						GGGCTTTGCTGGAGTTGCTGT	0.557													28	19					0	0	0.008361	0	0
MERTK	10461	broad.mit.edu	37	2	112740542	112740542	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:112740542C>T	uc002thk.1	+	8	1390	c.1268C>T	c.(1267-1269)TCC>TTC	p.S423F	MERTK_uc002thl.1_Missense_Mutation_p.S247F	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	423	Fibronectin type-III 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						TACCGGATATCCCACGTGTGG	0.463													17	56					0	0	0.007413	0	0
IL1F8	27177	broad.mit.edu	37	2	113783714	113783714	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:113783714G>A	uc002tiq.1	-	5	461	c.357C>T	c.(355-357)TTC>TTT	p.F119F		NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	119					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						gggttcccatgaagcagctct	0													22	22					0	0	0.001882	0	0
DDX18	8886	broad.mit.edu	37	2	118575251	118575251	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:118575251A>G	uc002tlh.1	+	2	416	c.317A>G	c.(316-318)GAA>GGA	p.E106G		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	106							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						TCCAATTCAGAATCAAAAAAG	0.353													39	122					0	0	0.006230	0	0
TFCP2L1	29842	broad.mit.edu	37	2	121989453	121989453	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:121989453G>A	uc002tmx.2	-	13	1383	c.1290C>T	c.(1288-1290)CAC>CAT	p.H430H	TFCP2L1_uc010flr.2_Intron|TFCP2L1_uc010flq.2_Intron	NM_014553	NP_055368	Q9NZI6	TF2L1_HUMAN	LBP-9	430					female pregnancy|steroid biosynthetic process	mitochondrion|nucleolus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			pancreas(2)|ovary(1)	3	Renal(3;0.01)					GGTAGACTCGGTGGATGTGCT	0.637													21	62					0	0	0.008871	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125547701	125547701	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:125547701G>A	uc002tno.2	+	18	3336	c.2972G>A	c.(2971-2973)GGG>GAG	p.G991E	CNTNAP5_uc010flu.2_Missense_Mutation_p.G992E	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	991	EGF-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCTTATGAAGGGCCCTTTTGC	0.522													11	37					0	0	0.008291	0	0
ARHGEF4	50649	broad.mit.edu	37	2	131688755	131688755	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:131688755G>A	uc002tsa.1	+	3	745	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	ARHGEF4_uc010fmw.1_Silent_p.Q721Q|ARHGEF4_uc002tsb.1_Silent_p.Q75Q|ARHGEF4_uc010fmx.1_Silent_p.Q75Q|ARHGEF4_uc002trz.1_Silent_p.Q721Q	NM_015320	NP_056135	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor 4 isoform	75	ABR (APC-binding region) domain.				apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			breast(3)|ovary(2)|skin(1)	6		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		AGAAGACACAGAGAAAGAAGT	0.597													11	20					0	0	0.008291	0	0
TUBA3D	113457	broad.mit.edu	37	2	132235797	132235797	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:132235797G>A	uc002tsu.3	+	2	171	c.64G>A	c.(64-66)GAA>AAA	p.E22K		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	22					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		TGCCTGCTGGGAACTGTACTG	0.512													65	70					0	0	0.003610	0	0
LCT	3938	broad.mit.edu	37	2	136570389	136570389	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:136570389C>T	uc002tuu.1	-	7	1856	c.1845G>A	c.(1843-1845)GAG>GAA	p.E615E		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	615	Extracellular (Potential).|4 X approximate repeats.|2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTCTCAGGTCCTCAGGCCTCT	0.602													13	46					0	0	0.002450	0	0
IFIH1	64135	broad.mit.edu	37	2	163134154	163134154	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:163134154C>T	uc002uce.2	-	10	2037	c.1815G>A	c.(1813-1815)AGG>AGA	p.R605R		NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	605					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						CATTGTACTTCCTCAAATGTT	0.328													22	62					0	0	0.001882	0	0
XIRP2	129446	broad.mit.edu	37	2	168103229	168103229	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:168103229G>A	uc002udx.2	+	8	5345	c.5327G>A	c.(5326-5328)GGA>GAA	p.G1776E	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.G1601E|XIRP2_uc010fpq.2_Missense_Mutation_p.G1554E|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1601					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAACAAGAAGGAGAGAAAGAA	0.398													55	24					0	0	0.003610	0	0
B3GALT1	8708	broad.mit.edu	37	2	168726177	168726177	+	Nonsense_Mutation	SNP	G	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:168726177G>T	uc002udz.1	+	2	979	c.628G>T	c.(628-630)GGA>TGA	p.G210*		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	210	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						TGTCATTAATGGAGGACCGAT	0.438													14	45					0.000151284	0.000228766	0.001855	1	0
LRP2	4036	broad.mit.edu	37	2	170097612	170097612	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:170097612G>A	uc002ues.2	-	25	4144	c.3931C>T	c.(3931-3933)CGC>TGC	p.R1311C	LRP2_uc010zdf.1_Missense_Mutation_p.R1174C	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	1311	LDL-receptor class A 15.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTAGGACAGCGAAAGGGCTGA	0.517													26	90					0	0	0.003330	0	0
CHN1	1123	broad.mit.edu	37	2	175664938	175664938	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:175664938G>A	uc002uji.2	-	13	1816	c.1286C>T	c.(1285-1287)TCT>TTT	p.S429F	CHN1_uc010zeq.1_Missense_Mutation_p.S403F|CHN1_uc002ujj.2_Missense_Mutation_p.S204F|CHN1_uc002ujg.2_Missense_Mutation_p.S304F	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	429	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			TAGTTCTGGAGATCTCATAAG	0.408			T	TAF15	extraskeletal myxoid chondrosarcoma								38	26					0	0	0.004878	0	0
OSBPL6	114880	broad.mit.edu	37	2	179170937	179170937	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:179170937C>T	uc002ulx.2	+	3	404	c.26C>T	c.(25-27)TCC>TTC	p.S9F	OSBPL6_uc002ulw.2_Missense_Mutation_p.S9F|OSBPL6_uc002uly.2_Missense_Mutation_p.S9F|OSBPL6_uc010zfe.1_Missense_Mutation_p.S9F|OSBPL6_uc002ulz.2_Missense_Mutation_p.S9F	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	9					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			AAGGGCATTTCCCCTGCTCAT	0.453													31	92					0	0	0.003755	0	0
TTN	7273	broad.mit.edu	37	2	179422027	179422027	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:179422027C>T	uc010zfg.1	-	278	80482	c.80258G>A	c.(80257-80259)GGA>GAA	p.G26753E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G20448E|TTN_uc010zfi.1_Missense_Mutation_p.G20381E|TTN_uc010zfj.1_Missense_Mutation_p.G20256E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27680							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTAGGTTTTCCAACTCCAGC	0.418													26	29					0	0	0.003954	0	0
TTN	7273	broad.mit.edu	37	2	179433686	179433686	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:179433686C>T	uc010zfg.1	-	275	69693	c.69469G>A	c.(69469-69471)GAT>AAT	p.D23157N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D16852N|TTN_uc010zfi.1_Missense_Mutation_p.D16785N|TTN_uc010zfj.1_Missense_Mutation_p.D16660N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24084							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCCACCATCATGTTCAGGT	0.418													87	91					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179495596	179495596	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:179495596C>T	uc010zfg.1	-	187	36609	c.36385G>A	c.(36385-36387)GAA>AAA	p.E12129K	TTN_uc010zfh.1_Missense_Mutation_p.E5824K|TTN_uc010zfi.1_Missense_Mutation_p.E5757K|TTN_uc010zfj.1_Missense_Mutation_p.E5632K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13056							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGAGATTTCGGTTTCAAAG	0.493													35	85					0	0	0.003271	0	0
TTN	7273	broad.mit.edu	37	2	179640203	179640203	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:179640203C>T	uc010zfg.1	-	28	6612	c.6388G>A	c.(6388-6390)GAA>AAA	p.E2130K	TTN_uc010zfh.1_Missense_Mutation_p.E2084K|TTN_uc010zfi.1_Missense_Mutation_p.E2084K|TTN_uc010zfj.1_Missense_Mutation_p.E2084K|TTN_uc002unb.2_Missense_Mutation_p.E2130K|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2130							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACATTGTCTTCGGGCCAGTAC	0.483													22	25					0	0	0.002299	0	0
COL5A2	1290	broad.mit.edu	37	2	189957116	189957116	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:189957116C>G	uc002uqk.2	-	7	762	c.487G>C	c.(487-489)GAA>CAA	p.E163Q		NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	163					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ACACCTGGTTCTCCATCAATT	0.517													5	13					0	0	0.001168	0	0
DNAH7	56171	broad.mit.edu	37	2	196602829	196602829	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:196602829C>T	uc002utj.3	-	65	11992	c.11891G>A	c.(11890-11892)AGG>AAG	p.R3964K	DNAH7_uc002uti.3_Missense_Mutation_p.R447K	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3964					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TATATCTGCCCTCTTACAGGG	0.413													9	22					0	0	0.008291	0	0
CCDC150	284992	broad.mit.edu	37	2	197521390	197521391	+	Silent	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:197521390_197521391CC>TT	uc002utp.1	+	3	345_346	c.210_211CC>TT	c.(208-213)GACCTG>GATTTG	p.70_71DL>DL	CCDC150_uc002uto.1_Silent_p.70_71DL>DL|CCDC150_uc010zgq.1_RNA|CCDC150_uc010zgr.1_Intron|CCDC150_uc010zgs.1_Intron	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	70_71											0						GTTTAGAAGACCTGGACAGCCA	0.366													10	16					0	0	0.004672	0	0
ICA1L	130026	broad.mit.edu	37	2	203693724	203693724	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:203693724G>A	uc002uzh.1	-	3	173	c.9C>T	c.(7-9)TCC>TCT	p.S3S	ICA1L_uc002uzi.1_Silent_p.S3S|ICA1L_uc002uzj.2_Silent_p.S3S|ICA1L_uc002uzk.1_Silent_p.S3S	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	3											0						GTTGCCCAAAGGAATCCATGG	0.274													121	308					0	0	0.003610	0	0
CDK5R2	8941	broad.mit.edu	37	2	219825520	219825520	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:219825520G>A	uc002vjf.2	+	1	1123	c.978G>A	c.(976-978)AAG>AAA	p.K326K		NM_003936	NP_003927	Q13319	CD5R2_HUMAN	cyclin-dependent kinase 5, regulatory subunit 2	326					regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase 5 holoenzyme complex	cyclin-dependent protein kinase 5 activator activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGACCTCAAGAACGAGGGCG	0.507													20	17					0	0	0.007413	0	0
CCDC108	255101	broad.mit.edu	37	2	219894278	219894278	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:219894278G>A	uc002vjl.1	-	11	1581	c.1497C>T	c.(1495-1497)TTC>TTT	p.F499F	CCDC108_uc010fwa.1_5'UTR|CCDC108_uc010zkp.1_Silent_p.F488F|CCDC108_uc010zkq.1_Silent_p.F434F	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	499						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGCAAACTGGAAGTGGGCCG	0.597											OREG0015211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	58					0	0	0.006122	0	0
SGPP2	130367	broad.mit.edu	37	2	223339413	223339413	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:223339413T>C	uc010zlo.1	+	2	346	c.346T>C	c.(346-348)TAT>CAT	p.Y116H	SGPP2_uc010zlp.1_5'UTR	NM_152386	NP_689599	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphotase 2	116					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(1)|skin(1)	2		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TATTGACCCTTATTTATCCAG	0.338													21	54					0	0	0.001882	0	0
DOCK10	55619	broad.mit.edu	37	2	225740795	225740795	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:225740795G>A	uc010fwz.1	-	8	1130	c.891C>T	c.(889-891)CTC>CTT	p.L297L	DOCK10_uc002vob.2_Silent_p.L291L|DOCK10_uc002vod.1_Silent_p.L297L	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	297							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TCCTCCCTTGGAGGGGCCCCT	0.512													21	72					0	0	0.002299	0	0
SP140	11262	broad.mit.edu	37	2	231134668	231134668	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:231134668G>A	uc002vql.2	+	14	1559	c.1444G>A	c.(1444-1446)GAT>AAT	p.D482N	SP140_uc010zma.1_RNA|SP140_uc002vqn.2_Missense_Mutation_p.D368N|SP140_uc002vqm.2_Missense_Mutation_p.D422N|SP140_uc010fxl.2_Missense_Mutation_p.D455N	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	482					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TGGCACAATGGGTAAGGCTGT	0.542													13	34					0	0	0.003163	0	0
DGKD	8527	broad.mit.edu	37	2	234367008	234367008	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:234367008C>T	uc002vui.1	+	22	2671	c.2659C>T	c.(2659-2661)CGA>TGA	p.R887*	DGKD_uc002vuj.1_Nonsense_Mutation_p.R843*|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	887					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GGCCGTCTCTCGAGTCATCAG	0.587													14	35					0	0	0.002450	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638323	234638323	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:234638323G>A	uc002vuy.2	+	1	551	c.551G>A	c.(550-552)GGC>GAC	p.G184D	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Missense_Mutation_p.G184D	NM_019093	NP_061966	P35503	UD13_HUMAN	UDP glycosyltransferase 1 family, polypeptide A3	184					flavonoid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(1)	1		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		GACTTTAAGGGCACACAGTGT	0.448													46	142					0	0	0.002852	0	0
PRLH	51052	broad.mit.edu	37	2	238475737	238475737	+	Silent	SNP	G	A	A	rs145946342	byFrequency	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr2:238475737G>A	uc010znl.1	+	2	183	c.183G>A	c.(181-183)GGG>GGA	p.G61G		NM_015893	NP_056977	P81277	PRRP_HUMAN	prolactin releasing hormone precursor	61						extracellular region					0		Lung NSC(271;0.142)|all_lung(227;0.175)		Epithelial(121;8.28e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.03e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.19e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000329)|Lung(119;0.0106)|LUSC - Lung squamous cell carcinoma(224;0.0249)		CAACCCTGGGGGACGTCCCCA	0.647													24	43					0	0	0.003954	0	0
PRND	23627	broad.mit.edu	37	20	4705311	4705311	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:4705311G>A	uc002wkz.2	+	2	185	c.114G>A	c.(112-114)AAG>AAA	p.K38K		NM_012409	NP_036541	Q9UKY0	PRND_HUMAN	prion-like protein doppel preproprotein	38	Flexible tail.				protein homooligomerization	anchored to membrane|plasma membrane					0						GGAACCGGAAGGCCCTGCCCA	0.617													37	18					0	0	0.003755	0	0
CHGB	1114	broad.mit.edu	37	20	5904000	5904000	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:5904000G>A	uc002wmg.2	+	4	1516	c.1210G>A	c.(1210-1212)GAA>AAA	p.E404K	CHGB_uc010zqz.1_Missense_Mutation_p.E87K	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	404						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						ATATGGTGAAGAAAGTGAGGA	0.542													19	93					0	0	0.008871	0	0
C20orf103	24141	broad.mit.edu	37	20	9498791	9498791	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:9498791G>A	uc002wni.1	+	5	809	c.580G>A	c.(580-582)GAT>AAT	p.D194N	C20orf103_uc010zrc.1_Missense_Mutation_p.D150N	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	194	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			GGCCTCTAGTGATCCGCAGAA	0.512													18	43					0	0	0.004990	0	0
JAG1	182	broad.mit.edu	37	20	10622123	10622123	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:10622123C>T	uc002wnw.2	-	23	3417	c.2901G>A	c.(2899-2901)AAG>AAA	p.K967K	JAG1_uc010gcd.1_Silent_p.K525K	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	967	Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						ACATCATCTCCTTGTTAAAGG	0.443									Alagille_Syndrome				88	70					0	0	0.003610	0	0
DEFB119	245932	broad.mit.edu	37	20	29965096	29965096	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:29965096C>T	uc002wvt.2	-	2	328	c.208G>A	c.(208-210)GAA>AAA	p.E70K	DEFB119_uc002wvs.2_3'UTR	NM_153289	NP_695021	Q8N690	DB119_HUMAN	defensin, beta 119 isoform a precursor	70					defense response to bacterium	extracellular region					0	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TCGGTATTTTCCTCTTTGCCA	0.488													63	53					0	0	0.003610	0	0
DUSP15	128853	broad.mit.edu	37	20	30438438	30438438	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:30438438G>A	uc002wwu.1	-	7	545	c.468C>T	c.(466-468)TGC>TGT	p.C156C				Q9H1R2	DUS15_HUMAN	RecName: Full=Dual specificity protein phosphatase 15;          EC=3.1.3.48;          EC=3.1.3.16; AltName: Full=Vaccinia virus VH1-related dual-specific protein phosphatase Y; AltName: Full=VH1-related member Y;	156						cytoplasm|plasma membrane	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			pancreas(1)	1			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TCATCGGAGGGCATTGGGCAC	0.602													6	16					0	0	0.003080	0	0
RBM12	10137	broad.mit.edu	37	20	34241641	34241641	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:34241641G>A	uc002xdq.2	-	3	1836	c.1604C>T	c.(1603-1605)CCA>CTA	p.P535L	CPNE1_uc010zvj.1_5'UTR|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdf.2_Intron|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_Intron|CPNE1_uc010gfj.2_Intron|CPNE1_uc002xdh.2_Intron|CPNE1_uc002xdi.2_Intron|CPNE1_uc002xdj.2_Intron|CPNE1_uc002xdk.2_Intron|CPNE1_uc002xdl.2_Intron|CPNE1_uc002xdm.2_Intron|CPNE1_uc010gfk.1_Intron|CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_Intron|CPNE1_uc002xdp.1_Intron|RBM12_uc002xdr.2_Missense_Mutation_p.P535L|RBM12_uc002xds.2_Missense_Mutation_p.P535L	NM_152838	NP_690051	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	535						nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			ATCCCCCTCTGGATTTAGTAT	0.393													62	197					0	0	0.003610	0	0
C20orf152	140894	broad.mit.edu	37	20	34568455	34568455	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:34568455C>T	uc002xes.1	+	4	474	c.318C>T	c.(316-318)GCC>GCT	p.A106A	C20orf152_uc002xer.1_Silent_p.A106A|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	106											0	Breast(12;0.00631)					AGATCCAGGCCGTCTGTAACA	0.542													46	43					0	0	0.002852	0	0
CDH22	64405	broad.mit.edu	37	20	44839064	44839064	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:44839064C>T	uc002xrm.2	-	6	1569	c.1168G>A	c.(1168-1170)GAG>AAG	p.E390K	CDH22_uc010ghk.1_Missense_Mutation_p.E390K|CDH22_uc002xrn.1_Missense_Mutation_p.E141K	NM_021248	NP_067071	Q9UJ99	CAD22_HUMAN	cadherin 22 precursor	390	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				TCGGGGGGCTCGTCCACGTCG	0.736													14	6					0	0	0.003163	0	0
KCNB1	3745	broad.mit.edu	37	20	47990052	47990052	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:47990052C>T	uc002xur.1	-	2	2209	c.2045G>A	c.(2044-2046)AGT>AAT	p.S682N	KCNB1_uc002xus.1_Missense_Mutation_p.S682N	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	682	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAGGAGTGGACTGGGGTCACC	0.547													15	53					0	0	0.004990	0	0
CTCFL	140690	broad.mit.edu	37	20	56078638	56078638	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:56078638G>A	uc010gix.1	-	9	2356	c.1694C>T	c.(1693-1695)TCG>TTG	p.S565L	CTCFL_uc010giw.1_Missense_Mutation_p.S565L|CTCFL_uc002xym.2_Missense_Mutation_p.S565L|CTCFL_uc010giz.1_Missense_Mutation_p.S153L|CTCFL_uc010giy.1_Missense_Mutation_p.S235L|CTCFL_uc010gja.1_Missense_Mutation_p.S515L|CTCFL_uc010gjb.1_Missense_Mutation_p.S565L|CTCFL_uc010gjc.1_Missense_Mutation_p.S565L|CTCFL_uc010gjd.1_Missense_Mutation_p.S565L|CTCFL_uc010gje.2_Missense_Mutation_p.S565L|CTCFL_uc010gjf.2_Missense_Mutation_p.S360L|CTCFL_uc010gjg.2_Missense_Mutation_p.S297L|CTCFL_uc010giu.2_RNA|CTCFL_uc010giv.2_RNA	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	565	C2H2-type 11; atypical.				cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			ACACTTCTCCGAATGTCTGTG	0.383													22	62					0	0	0.003954	0	0
ZNF831	128611	broad.mit.edu	37	20	57766216	57766216	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:57766216C>T	uc002yan.2	+	1	142	c.142C>T	c.(142-144)CTG>TTG	p.L48L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	48	Pro-rich.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGAGCAGGGCCTGGCCCCCCC	0.731													6	21					0	0	0.003080	0	0
COL9A3	1299	broad.mit.edu	37	20	61449889	61449889	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:61449889G>A	uc002ydm.2	+	3	170	c.167G>A	c.(166-168)GGT>GAT	p.G56D		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	56	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					GGTCCTCCAGGTCTGCCTGGG	0.582													26	91					0	0	0.003954	0	0
PTK6	5753	broad.mit.edu	37	20	62168557	62168557	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:62168557C>T	uc002yfg.2	-	1	151	c.111G>A	c.(109-111)GTG>GTA	p.V37V	PTK6_uc011aay.1_5'UTR|PTK6_uc011aba.1_Silent_p.V37V	NM_005975	NP_005966	Q13882	PTK6_HUMAN	PTK6 protein tyrosine kinase 6	37	SH3.					cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|kidney(1)	2	all_cancers(38;2.51e-11)		Epithelial(9;1.5e-08)|all cancers(9;8.67e-08)|BRCA - Breast invasive adenocarcinoma(10;6.43e-06)			CCTTCCTGGCCACGTGGAAGA	0.692													4	20					0	0	0.000248	0	0
PRIC285	85441	broad.mit.edu	37	20	62194214	62194214	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr20:62194214G>A	uc002yfm.2	-	9	6853	c.5961C>T	c.(5959-5961)TTC>TTT	p.F1987F	PRIC285_uc002yfl.1_Silent_p.F1418F	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	1987					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CCTCCAGGCGGAAGGCGCCCT	0.677													5	26					0	0	0.000602	0	0
RWDD2B	10069	broad.mit.edu	37	21	30380788	30380788	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr21:30380788C>T	uc002yms.2	-	2	309	c.222G>A	c.(220-222)AAG>AAA	p.K74K	RWDD2B_uc002ymt.2_Silent_p.K45K|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_5'UTR	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	74	RWD.										0						CCTCCATTGTCTTCTTTTCAA	0.403													36	63					0	0	0.004289	0	0
ITSN1	6453	broad.mit.edu	37	21	35169762	35169762	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr21:35169762G>A	uc002yta.1	+	18	2300	c.2032G>A	c.(2032-2034)GAA>AAA	p.E678K	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E678K|ITSN1_uc010gmg.2_Missense_Mutation_p.E641K|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E678K|ITSN1_uc010gmi.2_Missense_Mutation_p.E641K|ITSN1_uc010gmj.2_Missense_Mutation_p.E562K|ITSN1_uc002ysy.2_Missense_Mutation_p.E678K|ITSN1_uc002ysx.2_Missense_Mutation_p.E641K|ITSN1_uc002ytb.1_Missense_Mutation_p.E678K|ITSN1_uc002ytc.1_Missense_Mutation_p.E678K|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E641K|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E678K|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E612K	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	678	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AAAACTCCACGAAGAGGAAAA	0.502													50	83					0	0	0.003610	0	0
ZNF295	49854	broad.mit.edu	37	21	43412714	43412714	+	Silent	SNP	T	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr21:43412714T>C	uc002zab.3	-	3	1705	c.1491A>G	c.(1489-1491)TTA>TTG	p.L497L	ZNF295_uc002yzz.3_Silent_p.L497L|ZNF295_uc002yzy.3_Silent_p.L497L|ZNF295_uc002zaa.3_Silent_p.L497L|ZNF295_uc010gov.1_Silent_p.L497L|ZNF295_uc002zac.2_Silent_p.L497L	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	497					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CATTCACCTTTAACTTCTTAA	0.443													67	83					0	0	0.003610	0	0
ABCG1	9619	broad.mit.edu	37	21	43702515	43702515	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr21:43702515C>T	uc002zaq.2	+	6	826	c.720C>T	c.(718-720)TTC>TTT	p.F240F	ABCG1_uc002zan.2_Silent_p.F242F|ABCG1_uc002zam.2_Silent_p.F218F|ABCG1_uc002zao.2_Silent_p.F237F|ABCG1_uc002zap.2_Silent_p.F240F|ABCG1_uc002zar.2_Silent_p.F251F|ABCG1_uc011aev.1_Silent_p.F251F	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	240	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	TCATGTTCTTCGATGAGCCCA	0.607													8	27					0	0	0.003080	0	0
CBS	875	broad.mit.edu	37	21	44485567	44485567	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr21:44485567G>A	uc002zcu.2	-	7	841	c.596C>T	c.(595-597)TCC>TTC	p.S199F	CBS_uc002zcs.1_Missense_Mutation_p.S94F|CBS_uc002zct.2_Missense_Mutation_p.S199F|CBS_uc002zcw.3_Missense_Mutation_p.S199F|CBS_uc002zcv.2_Missense_Mutation_p.S199F	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	199					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	TGACTCCGGGGAGTCGAACCT	0.642													187	278					0	0	0.003610	0	0
SLC7A4	6545	broad.mit.edu	37	22	21384575	21384575	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr22:21384575C>T	uc002zud.2	-	3	1116	c.1048G>A	c.(1048-1050)GAT>AAT	p.D350N	SLC7A4_uc002zue.2_Missense_Mutation_p.D350N	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	350					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AAGAGCCCATCGGCGGCCATG	0.642													40	10					0	0	0.003610	0	0
MYO18B	84700	broad.mit.edu	37	22	26423393	26423393	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr22:26423393C>T	uc003abz.1	+	43	7703	c.7453C>T	c.(7453-7455)CTC>TTC	p.L2485F	MYO18B_uc003aca.1_Missense_Mutation_p.L2366F|MYO18B_uc010guy.1_Missense_Mutation_p.L2367F|MYO18B_uc010guz.1_Missense_Mutation_p.L2365F|MYO18B_uc011aka.1_Missense_Mutation_p.L1639F|MYO18B_uc011akb.1_Missense_Mutation_p.L1998F|MYO18B_uc010gva.1_Missense_Mutation_p.L468F|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2485						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCGTTCCTTTCTCTCGGGGAT	0.557													24	5					0	0	0.002299	0	0
SEZ6L	23544	broad.mit.edu	37	22	26692950	26692950	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr22:26692950G>A	uc003acb.2	+	4	1222	c.1066G>A	c.(1066-1068)GAG>AAG	p.E356K	SEZ6L_uc003acc.2_Missense_Mutation_p.E356K|SEZ6L_uc011akc.1_Missense_Mutation_p.E356K|SEZ6L_uc003acd.2_Missense_Mutation_p.E356K|SEZ6L_uc011akd.1_Missense_Mutation_p.E356K|SEZ6L_uc003ace.2_Missense_Mutation_p.E356K|SEZ6L_uc003acf.1_Missense_Mutation_p.E129K|SEZ6L_uc010gvc.1_Missense_Mutation_p.E129K	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	356	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						ACTCCTGGTGGAGGGGCAGGT	0.622													24	11					0	0	0.003330	0	0
SEZ6L	23544	broad.mit.edu	37	22	26736542	26736542	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr22:26736542C>T	uc003acb.2	+	10	2312	c.2156C>T	c.(2155-2157)TCG>TTG	p.S719L	SEZ6L_uc003acc.2_Missense_Mutation_p.S719L|SEZ6L_uc011akc.1_Missense_Mutation_p.S719L|SEZ6L_uc003acd.2_Missense_Mutation_p.S719L|SEZ6L_uc011akd.1_Missense_Mutation_p.S719L|SEZ6L_uc003ace.2_Missense_Mutation_p.S719L|SEZ6L_uc003acf.1_Missense_Mutation_p.S492L|SEZ6L_uc010gvc.1_Missense_Mutation_p.S492L	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	719	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CAGTTCCATTCGGACCCTGCT	0.498													39	14					0	0	0.002222	0	0
TMEM184B	25829	broad.mit.edu	37	22	38622800	38622800	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr22:38622800C>T	uc003avf.1	-	6	827	c.603G>A	c.(601-603)CGG>CGA	p.R201R	TMEM184B_uc003avg.1_Silent_p.R201R|TMEM184B_uc003avh.1_Silent_p.R135R|TMEM184B_uc010gxl.1_Intron	NM_012264	NP_036396	Q9Y519	T184B_HUMAN	transmembrane protein 184B	201						integral to membrane					0	Melanoma(58;0.045)					AGTCCCCATCCCGGTACTTGC	0.637													14	3					0	0	0.002450	0	0
TTLL12	23170	broad.mit.edu	37	22	43575962	43575962	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr22:43575962G>A	uc003bdq.2	-	4	623	c.591C>T	c.(589-591)TTC>TTT	p.F197F	TTLL12_uc003bdr.1_Silent_p.F197F	NM_015140	NP_055955	Q14166	TTL12_HUMAN	tubulin tyrosine ligase-like family, member 12	197					protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)	1		Ovarian(80;0.221)|Glioma(61;0.222)				TCCGCGAACCGAACTCGTCCA	0.622													49	18					0	0	0.003610	0	0
GRM7	2917	broad.mit.edu	37	3	7620949	7620949	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:7620949G>A	uc003bqm.2	+	8	2630	c.2356G>A	c.(2356-2358)GAA>AAA	p.E786K	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.E786K|GRM7_uc003bql.2_Missense_Mutation_p.E786K|GRM7_uc003bqn.1_Missense_Mutation_p.E369K|GRM7_uc010hch.1_Missense_Mutation_p.E297K	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	786	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GAATTTTAACGAAGCCAAGCC	0.433													38	23					0	0	0.003755	0	0
ATP2B2	491	broad.mit.edu	37	3	10417121	10417121	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:10417121G>A	uc003bvt.2	-	11	1848	c.1409C>T	c.(1408-1410)TCG>TTG	p.S470L	ATP2B2_uc003bvv.2_Missense_Mutation_p.S425L|ATP2B2_uc003bvw.2_Missense_Mutation_p.S425L|ATP2B2_uc010hdo.2_Missense_Mutation_p.S175L	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	470	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CACCTTCACCGAATAGGCCAA	0.627													19	55					0	0	0.007413	0	0
Unknown	0	broad.mit.edu	37	3	12299495	12299495	+	RNA	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:12299495G>A	uc003bwp.1	-	1		c.458C>T				NR_003112				NR_003112																		CCACATAGGTGATCTTGTCTC	0.483													7	23					0	0	0.001984	0	0
PLCL2	23228	broad.mit.edu	37	3	17052315	17052315	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:17052315C>T	uc011awc.1	+	5	1558	c.1453C>T	c.(1453-1455)CAG>TAG	p.Q485*	PLCL2_uc010het.1_Intron|PLCL2_uc011awd.1_Nonsense_Mutation_p.Q367*	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	493	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						CATGACCTCTCAGATAGTTTT	0.398													27	35					0	0	0.004656	0	0
NR1D2	9975	broad.mit.edu	37	3	24001236	24001236	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:24001236G>T	uc003ccs.2	+	4	766	c.447G>T	c.(445-447)ATG>ATT	p.M149I	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.M74I	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	149	Nuclear receptor.|NR C4-type.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						GTTCTATAATGAGAATGAATA	0.368													21	61					1.15919e-05	1.75822e-05	0.008871	1	0
THRB	7068	broad.mit.edu	37	3	24188267	24188267	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:24188267G>A	uc003ccx.3	-	7	780	c.431C>T	c.(430-432)TCC>TTC	p.S144F	THRB_uc010hfe.2_Missense_Mutation_p.S144F|THRB_uc003ccy.3_Missense_Mutation_p.S144F|THRB_uc003ccz.3_Missense_Mutation_p.S139F	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	144	Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	ATATTTACAGGAATAGGATGG	0.363													14	52					0	0	0.002450	0	0
DLEC1	9940	broad.mit.edu	37	3	38087060	38087060	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:38087060G>A	uc003cho.1	+	2	459	c.438G>A	c.(436-438)CTG>CTA	p.L146L	DLEC1_uc003chp.1_Silent_p.L146L|DLEC1_uc010hgv.1_Silent_p.L146L	NM_007335	NP_031361	Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1 isoform	146					negative regulation of cell proliferation	cytoplasm				ovary(2)|pancreas(2)|central_nervous_system(2)|skin(2)|breast(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AGCAGCGGCTGGATGAGTTTG	0.498													29	56					0	0	0.007291	0	0
KIF15	56992	broad.mit.edu	37	3	44867530	44867530	+	Splice_Site	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:44867530G>A	uc003cnx.3	+	21	2699	c.2550_splice	c.e21-1	p.R850_splice	KIF15_uc010hiq.2_Splice_Site_p.R753_splice|KIF15_uc010hir.2_Splice_Site	NM_020242	NP_064627	Q9NS87	KIF15_HUMAN	kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TCCTTATAAAGGTTAGAAAAC	0.318													12	54					0	0	0.001855	0	0
LARS2	23395	broad.mit.edu	37	3	45537800	45537800	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:45537800G>A	uc003cop.1	+	14	1742	c.1557G>A	c.(1555-1557)ACG>ACA	p.T519T	LARS2_uc010hit.1_Silent_p.T476T	NM_015340	NP_056155	Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	519					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	AGACAGACACGATGGATACCT	0.388													39	137					0	0	0.004878	0	0
PRSS50	29122	broad.mit.edu	37	3	46753880	46753880	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:46753880C>T	uc003cqe.1	-	6	1073	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	PRSS50_uc003cqf.1_Silent_p.E252E	NM_013270	NP_037402	Q9UI38	TSP50_HUMAN	testes-specific protease 50 precursor	338	Peptidase S1.				proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity				0						TGGGTGGGGCCTCGCTCTTCT	0.642													16	17					0	0	0.004990	0	0
CELSR3	1951	broad.mit.edu	37	3	48698609	48698609	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:48698609C>T	uc003cul.2	-	1	1740	c.1459G>A	c.(1459-1461)GAG>AAG	p.E487K	CELSR3_uc003cuf.1_Missense_Mutation_p.E557K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	487	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGATCAATCTCGAAGGCGGCG	0.697													8	1					0	0	0.003080	0	0
BSN	8927	broad.mit.edu	37	3	49698954	49698954	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:49698954A>T	uc003cxe.3	+	6	9790	c.9676A>T	c.(9676-9678)AAC>TAC	p.N3226Y		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3226					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCTGGAGCAGAACGTTCCTCG	0.592													32	81					0	0	0.002445	0	0
DOCK3	1795	broad.mit.edu	37	3	51352435	51352435	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:51352435C>T	uc011bds.1	+	32	3301	c.3278C>T	c.(3277-3279)CCG>CTG	p.P1093L		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1093						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CACTTTATTCCGGGAATGATT	0.453													5	15					0	0	0.001168	0	0
DNAH1	25981	broad.mit.edu	37	3	52434413	52434413	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:52434413G>A	uc011bef.1	+	78	13010	c.12749G>A	c.(12748-12750)CGA>CAA	p.R4250Q	DNAH1_uc003ddv.2_3'UTR	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	4315					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CAGCCCCAGCGACACTGGATA	0.537													61	62					0	0	0.003610	0	0
STAB1	23166	broad.mit.edu	37	3	52542315	52542315	+	Silent	SNP	C	T	T	rs148343623	by1000genomes	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:52542315C>T	uc003dej.2	+	21	2249	c.2175C>T	c.(2173-2175)TTC>TTT	p.F725F	STAB1_uc003dei.1_Silent_p.F725F	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	725	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		AAGGTTTTTTCGGGCCTGACT	0.587													19	66					0	0	0.008871	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54919598	54919598	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:54919598G>A	uc003dhf.2	+	23	2089	c.2041G>A	c.(2041-2043)GAA>AAA	p.E681K	CACNA2D3_uc011beu.1_RNA|CACNA2D3_uc003dhg.1_Missense_Mutation_p.E587K|CACNA2D3_uc003dhh.1_RNA|CACNA2D3_uc010hmv.1_Missense_Mutation_p.E415K|uc003dhk.1_Intron	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	681	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		AAAAGGCAAAGAACCTCTGCT	0.468													9	20					0	0	0.006214	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55107559	55107559	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:55107559C>T	uc003dhf.2	+	36	3123	c.3075C>T	c.(3073-3075)ATC>ATT	p.I1025I	CACNA2D3_uc003dhg.1_Silent_p.I931I|CACNA2D3_uc003dhh.1_RNA	NM_018398	NP_060868	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha	1025	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			large_intestine(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGGCCCCCATCACCATGGCAC	0.522													15	46					0	0	0.003163	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64673245	64673245	+	Missense_Mutation	SNP	C	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:64673245C>A	uc003dmg.2	-	1	121	c.89G>T	c.(88-90)CGC>CTC	p.R30L	ADAMTS9_uc011bfo.1_Missense_Mutation_p.R30L|ADAMTS9_uc003dmh.1_5'Flank|ADAMTS9_uc003dmk.1_Missense_Mutation_p.R30L|uc003dml.2_Intron	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	30					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CCTGTCCTTGCGCACGGCCGC	0.562													38	30					3.76604e-16	5.75608e-16	0.002522	1	0
ARL6IP5	10550	broad.mit.edu	37	3	69153703	69153703	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:69153703G>A	uc003dnr.2	+	3	592	c.483G>A	c.(481-483)CCG>CCA	p.P161P		NM_006407	NP_006398	O75915	PRAF3_HUMAN	ADP-ribosylation-like factor 6 interacting	161	Cytoplasmic (By similarity).|Targeting to endoplasmic reticulum membrane (By similarity).				L-glutamate transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.78e-05)|Epithelial(33;0.000818)|LUSC - Lung squamous cell carcinoma(21;0.0118)|Lung(16;0.0189)|KIRC - Kidney renal clear cell carcinoma(39;0.203)|Kidney(39;0.238)		AGAGGACACCGATGGGCATTG	0.438													15	40					0	0	0.002450	0	0
CHMP2B	25978	broad.mit.edu	37	3	87294927	87294927	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:87294927C>T	uc003dqp.3	+	3	450	c.190C>T	c.(190-192)CAA>TAA	p.Q64*	CHMP2B_uc011bgn.1_Nonsense_Mutation_p.Q23*	NM_014043	NP_054762	Q9UQN3	CHM2B_HUMAN	chromatin modifying protein 2B	64					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane|mitochondrion|nucleus	protein domain specific binding	p.Q64Q(1)		skin(2)|ovary(1)	3	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		TTTAGCCAAACAACTTGTGCA	0.313													28	30					0	0	0.005443	0	0
MYH15	22989	broad.mit.edu	37	3	108117669	108117669	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:108117669C>T	uc003dxa.1	-	36	5065	c.5008G>A	c.(5008-5010)GAT>AAT	p.D1670N		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1670	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GTGCTGTCATCCAGCTGCATT	0.498													43	124					0	0	0.007835	0	0
CD200	4345	broad.mit.edu	37	3	112054804	112054804	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:112054804A>G	uc003dyw.2	+	2	171	c.27A>G	c.(25-27)ACA>ACG	p.T9T	CD200_uc010hqd.1_Intron|CD200_uc003dyx.2_Intron|CD200_uc003dyy.2_Intron|CD200_uc003dyz.2_Intron	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	Error:Variant_position_missing_in_P41217_after_alignment					regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				TGACCAGGACAATTGGGGGCC	0.274													70	71					0	0	0.003610	0	0
KTELC1	56983	broad.mit.edu	37	3	119190234	119190234	+	Silent	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:119190234A>T	uc003ecm.2	+	3	339	c.255A>T	c.(253-255)CTA>CTT	p.L85L	KTELC1_uc011biz.1_RNA|KTELC1_uc011bja.1_5'UTR	NM_152305	NP_689518	Q8NBL1	PGLT1_HUMAN	KTEL (Lys-Tyr-Glu-Leu) containing 1 precursor	85						endoplasmic reticulum lumen	UDP-glucosyltransferase activity				0				GBM - Glioblastoma multiforme(114;0.233)		GACGGAAGCTAGGGACCCACT	0.468													78	55					0	0	0.003610	0	0
STXBP5L	9515	broad.mit.edu	37	3	120628589	120628589	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:120628589C>T	uc003eec.3	+	2	304	c.164C>T	c.(163-165)ACT>ATT	p.T55I	STXBP5L_uc011bji.1_Missense_Mutation_p.T55I	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	55					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GAAACTTTGACTTCGGAGTAT	0.448													6	35					0	0	0.003080	0	0
POLQ	10721	broad.mit.edu	37	3	121206697	121206697	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:121206697G>A	uc003eee.3	-	16	5210	c.5081C>T	c.(5080-5082)TCA>TTA	p.S1694L	POLQ_uc003eed.2_Missense_Mutation_p.S866L	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1694	Potential.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		AGAAGAAAATGAAATTCCCTG	0.308								DNA_polymerases_(catalytic_subunits)					14	63					0	0	0.003163	0	0
SLC12A8	84561	broad.mit.edu	37	3	124807165	124807165	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:124807165G>A	uc003ehv.3	-	13	2082	c.1971C>T	c.(1969-1971)CTC>CTT	p.L657L	SLC12A8_uc003ehw.3_Silent_p.L686L|SLC12A8_uc003eht.3_Silent_p.L458L|SLC12A8_uc003ehu.3_Silent_p.L410L|SLC12A8_uc010hry.2_Intron	NM_024628	NP_078904	A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	657					potassium ion transport	integral to membrane	symporter activity				0						TGCAGGAGGGGAGCAAGAGAG	0.517													16	22					0	0	0.006122	0	0
PLXND1	23129	broad.mit.edu	37	3	129291459	129291459	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:129291459C>T	uc003emx.2	-	15	3170	c.3070G>A	c.(3070-3072)GAG>AAG	p.E1024K		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1024	Extracellular (Potential).|IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						TACATCAGCTCCGTGCAGGGG	0.637													15	17					0	0	0.004007	0	0
COL6A6	131873	broad.mit.edu	37	3	130300460	130300460	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:130300460G>A	uc010htl.2	+	8	3634	c.3603G>A	c.(3601-3603)CAG>CAA	p.Q1201Q	COL6A6_uc003eni.3_5'Flank	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1201	VWFA 7.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						AGAAAGGGCAGACTTTGCTTG	0.463													29	69					0	0	0.002445	0	0
VPS8	23355	broad.mit.edu	37	3	184769774	184769774	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:184769774C>T	uc003fpb.1	+	47	4413	c.4242C>T	c.(4240-4242)TTC>TTT	p.F1414F	VPS8_uc010hyd.1_Silent_p.F1324F|VPS8_uc010hye.1_Silent_p.F843F	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1416							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			ATGAGAACTTCCAGCTGCAGC	0.562													17	39					0	0	0.004990	0	0
DGKG	1608	broad.mit.edu	37	3	185969598	185969598	+	Missense_Mutation	SNP	C	T	T	rs79928844		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:185969598C>T	uc003fqa.2	-	19	2248	c.1711G>A	c.(1711-1713)GGG>AGG	p.G571R	DGKG_uc003fqb.2_Missense_Mutation_p.G532R|DGKG_uc003fqc.2_Missense_Mutation_p.G546R|DGKG_uc011brx.1_Missense_Mutation_p.G512R	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	571					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	ACCTGGTCCCCGTTTTCCACT	0.507													25	76					0	0	0.005443	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186572200	186572200	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:186572200G>A	uc003fra.2	+	3	526	c.442G>A	c.(442-444)GGT>AGT	p.G148S	ADIPOQ_uc010hyy.2_Missense_Mutation_p.G148S	NM_004797	NP_004788	Q15848	ADIPO_HUMAN	adiponectin precursor	148	C1q.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity	p.G148V(1)		ovary(1)	1	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		TGGCTCCACTGGTAAATTCCA	0.453													38	45					0	0	0.005524	0	0
MFI2	4241	broad.mit.edu	37	3	196737653	196737653	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr3:196737653C>T	uc003fxk.3	-	10	1359	c.1246G>A	c.(1246-1248)GAC>AAC	p.D416N		NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	416	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GTCACAGCGTCGACCTGCTCA	0.662													18	42					0	0	0.008871	0	0
JAKMIP1	152789	broad.mit.edu	37	4	6064047	6064047	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:6064047C>T	uc003giu.3	-	10	1828	c.1552G>A	c.(1552-1554)GAG>AAG	p.E518K	JAKMIP1_uc010idb.1_Missense_Mutation_p.E518K|JAKMIP1_uc010idc.1_Missense_Mutation_p.E333K|JAKMIP1_uc010idd.1_Intron|JAKMIP1_uc011bwc.1_Missense_Mutation_p.E353K|JAKMIP1_uc003giv.3_Missense_Mutation_p.E518K|JAKMIP1_uc010ide.2_Missense_Mutation_p.E518K	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	518	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ACCCGGGCCTCCCTCTCAGCG	0.662													27	36					0	0	0.006320	0	0
WFS1	7466	broad.mit.edu	37	4	6288872	6288872	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:6288872C>T	uc003giy.2	+	3	451	c.285C>T	c.(283-285)GCC>GCT	p.A95A	WFS1_uc003gix.2_Silent_p.A95A|WFS1_uc003giz.2_5'Flank	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	95					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		TGGAGAGGGCCAAGGCCGGGG	0.592													64	142					0	0	0.003610	0	0
MAN2B2	23324	broad.mit.edu	37	4	6612845	6612845	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:6612845C>T	uc003gjf.1	+	15	2439	c.2403C>T	c.(2401-2403)TTC>TTT	p.F801F	MAN2B2_uc003gje.1_Silent_p.F801F|MAN2B2_uc011bwf.1_Silent_p.F750F	NM_015274	NP_056089	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	801					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			ovary(2)	2						GGAACAACTTCGACTGGGACC	0.657													11	19					0	0	0.008291	0	0
CPZ	8532	broad.mit.edu	37	4	8616199	8616199	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:8616199G>A	uc003glm.2	+	9	1603	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.E356K|CPZ_uc003glo.2_Missense_Mutation_p.E482K|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	493					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCACAACAAGGAGTCACTCCT	0.592													13	22					0	0	0.004007	0	0
CLNK	116449	broad.mit.edu	37	4	10599619	10599619	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:10599619G>A	uc003gmo.3	-	3	203	c.66C>T	c.(64-66)TTC>TTT	p.F22F	CLNK_uc003gmp.2_5'UTR	NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	22					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						TTGGCAGACTGAAGTTCTGGA	0.338													5	6					0	0	0.000602	0	0
ZCCHC4	29063	broad.mit.edu	37	4	25314461	25314461	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:25314461C>T	uc003grl.3	+	1	66	c.30C>T	c.(28-30)GCC>GCT	p.A10A		NM_024936	NP_079212	Q9H5U6	ZCHC4_HUMAN	zinc finger, CCHC domain containing 4	10							methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(2)	2		Breast(46;0.0503)				GGTTTGAAGCCGTGGAGGCAG	0.652											OREG0016141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	84					0	0	0.003610	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984913	41984913	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:41984913C>T	uc003gwk.2	+	1	1201	c.1104C>T	c.(1102-1104)TTC>TTT	p.F368F		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	368										skin(1)	1						GCGTGGCCTTCGCTTCTCGGC	0.607													10	22					0	0	0.006214	0	0
BEND4	389206	broad.mit.edu	37	4	42122147	42122148	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:42122147_42122148CC>TT	uc003gwn.2	-	5	1890_1891	c.1310_1311GG>AA	c.(1309-1311)AGG>AAA	p.R437K	BEND4_uc003gwm.2_Missense_Mutation_p.R437K|BEND4_uc011byy.1_Missense_Mutation_p.R437K	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	437	BEN.										0						CTGACCTTTTCCTTTTCCCAAG	0.485													10	21					0	0	0.004672	0	0
AASDH	132949	broad.mit.edu	37	4	57209809	57209809	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:57209809G>A	uc003hbn.2	-	13	2847	c.2694C>T	c.(2692-2694)GTC>GTT	p.V898V	AASDH_uc010ihb.2_Silent_p.V413V|AASDH_uc011caa.1_Missense_Mutation_p.L691F|AASDH_uc003hbo.2_Silent_p.V798V|AASDH_uc011cab.1_Silent_p.V413V|AASDH_uc010ihc.2_Intron	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	898					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			ovary(4)	4	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				GAGAGGAAAAGACAGTTCCTC	0.348													8	13					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	4	69327576	69327576	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:69327576G>A	uc003hdz.3	+	2	113	c.49G>A	c.(49-51)GAA>AAA	p.E17K		NM_014058	NP_054777			transmembrane protease, serine 11E																		AGTTTGTTGGGAACCCTGGGT	0.418													103	155					0	0	0.003610	0	0
UGT2B10	7365	broad.mit.edu	37	4	69696495	69696495	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:69696495C>T	uc003hee.2	+	6	1510	c.1485C>T	c.(1483-1485)TTC>TTT	p.F495F	UGT2B10_uc011cam.1_Silent_p.F411F	NM_001075	NP_001066	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2B10 isoform 1	495	Helical; (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TGATTGGGTTCCTGCTGGCTT	0.453													29	75					0	0	0.008361	0	0
ANKRD17	26057	broad.mit.edu	37	4	73962883	73962883	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:73962883G>C	uc003hgp.2	-	27	5245	c.5128C>G	c.(5128-5130)CCT>GCT	p.P1710A	ANKRD17_uc003hgo.2_Missense_Mutation_p.P1597A|ANKRD17_uc003hgq.2_Missense_Mutation_p.P1459A|ANKRD17_uc003hgr.2_Missense_Mutation_p.P1709A	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1710					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCACGCTTAGGACTTGCTACT	0.388													39	96					0	0	0.002852	0	0
AFM	173	broad.mit.edu	37	4	74354467	74354467	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:74354467C>T	uc003hhb.2	+	7	865	c.834C>T	c.(832-834)ATC>ATT	p.I278I		NM_001133	NP_001124	P43652	AFAM_HUMAN	afamin precursor	278	Albumin 2.				vitamin transport		vitamin E binding			ovary(2)|central_nervous_system(1)	3	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCAGTGCATCCGTGACACGG	0.358													27	40					0	0	0.005443	0	0
AREG	374	broad.mit.edu	37	4	75312296	75312296	+	Missense_Mutation	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:75312296A>G	uc011cbl.1	+	2	317	c.107A>G	c.(106-108)AAG>AGG	p.K36R		NM_001657	NP_001648	P15514	AREG_HUMAN	amphiregulin preproprotein	36					cell proliferation|cell-cell signaling|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|positive regulation of DNA replication	cell surface|extracellular space|integral to membrane	cytokine activity|growth factor activity				0			Lung(101;0.196)			TACTCTGGGAAGCGTGAACCA	0.478													55	99					0	0	0.003610	0	0
CCDC158	339965	broad.mit.edu	37	4	77250090	77250090	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:77250090C>T	uc003hkb.3	-	21	3114	c.2961G>A	c.(2959-2961)AGG>AGA	p.R987R		NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	987	Ser-rich.									skin(3)|ovary(2)|pancreas(1)	6						AGGGATCTTCCCTGTCTCCTG	0.358													15	26					0	0	0.002450	0	0
SHROOM3	57619	broad.mit.edu	37	4	77660587	77660588	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:77660587_77660588GG>AA	uc011cbx.1	+	5	2214_2215	c.1261_1262GG>AA	c.(1261-1263)GGC>AAC	p.G421N	SHROOM3_uc011cbz.1_Missense_Mutation_p.G245N|SHROOM3_uc003hkf.1_Missense_Mutation_p.G296N|SHROOM3_uc003hkg.2_Missense_Mutation_p.G199N	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	421					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			AAACTCTTTAGGCTCCCTGAAG	0.559													12	29					0	0	0.004672	0	0
HSD17B11	51170	broad.mit.edu	37	4	88258508	88258508	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:88258508C>T	uc003hqp.2	-	7	1056	c.823G>A	c.(823-825)GAG>AAG	p.E275K		NM_016245	NP_057329	Q8NBQ5	DHB11_HUMAN	estradiol 17-beta-dehydrogenase 11	275					androgen catabolic process|steroid biosynthetic process	cytoplasm|extracellular region	binding|estradiol 17-beta-dehydrogenase activity			ovary(2)	2		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000339)		AGGAAACGCTCAGGAAGGATC	0.294													14	27					0	0	0.003163	0	0
MTTP	4547	broad.mit.edu	37	4	100527972	100527972	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:100527972G>A	uc003hvc.3	+	12	1668	c.1412G>A	c.(1411-1413)AGG>AAG	p.R471K	MTTP_uc011cej.1_Missense_Mutation_p.R498K	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	471	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GAGGACACCAGGATGTATCTG	0.458													18	33					0	0	0.006122	0	0
CENPE	1062	broad.mit.edu	37	4	104079935	104079935	+	Missense_Mutation	SNP	G	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:104079935G>T	uc003hxb.1	-	23	2800	c.2710C>A	c.(2710-2712)CAA>AAA	p.Q904K	CENPE_uc003hxc.1_Missense_Mutation_p.Q879K	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	904	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TCTACAGTTTGCAGCGTAGAA	0.358													18	24					6.94344e-10	1.058e-09	0.006122	1	0
ANK2	287	broad.mit.edu	37	4	114254312	114254312	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:114254312C>G	uc003ibe.3	+	29	3427	c.3327C>G	c.(3325-3327)TTC>TTG	p.F1109L	ANK2_uc003ibd.3_Missense_Mutation_p.F1100L|ANK2_uc003ibf.3_Missense_Mutation_p.F1109L|ANK2_uc011cgc.1_Missense_Mutation_p.F285L|ANK2_uc003ibg.3_Missense_Mutation_p.F104L|ANK2_uc003ibc.2_Missense_Mutation_p.F1085L|ANK2_uc011cgb.1_Missense_Mutation_p.F1124L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1076	Interaction with SPTBN1.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGAGCATTTCTGTGACTACA	0.453													26	31					0	0	0.005443	0	0
ARSJ	79642	broad.mit.edu	37	4	114824459	114824459	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:114824459C>T	uc003ibq.1	-	2	1659	c.771G>A	c.(769-771)AAG>AAA	p.K257K	ARSJ_uc010imu.1_Silent_p.K257K|ARSJ_uc010imv.1_Silent_p.K85K	NM_024590	NP_078866	Q5FYB0	ARSJ_HUMAN	arylsulfatase J precursor	257						extracellular region	arylsulfatase activity|metal ion binding			ovary(1)	1		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		AAAATATAGGCTTTGTGGGGT	0.418													21	48					0	0	0.008871	0	0
UGT8	7368	broad.mit.edu	37	4	115586899	115586899	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:115586899A>T	uc003ibs.2	+	4	1551	c.1029A>T	c.(1027-1029)CAA>CAT	p.Q343H	UGT8_uc003ibt.2_Missense_Mutation_p.Q343H|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	343					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		GGTTACCACAAAATGACCTGC	0.323													16	27					0	0	0.004990	0	0
FAT4	79633	broad.mit.edu	37	4	126371324	126371324	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:126371324G>A	uc003ifj.3	+	9	9153	c.9153G>A	c.(9151-9153)TTG>TTA	p.L3051L	FAT4_uc011cgp.1_Silent_p.L1349L|FAT4_uc003ifi.1_Silent_p.L529L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3051	Extracellular (Potential).|Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTTCTGACTTGAACCAAAACT	0.388													16	22					0	0	0.003163	0	0
PCDH18	54510	broad.mit.edu	37	4	138451538	138451538	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:138451538C>T	uc003ihe.3	-	1	2092	c.1705G>A	c.(1705-1707)GAA>AAA	p.E569K	PCDH18_uc003ihf.3_Missense_Mutation_p.E562K|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.E349K|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	569	Extracellular (Potential).|Cadherin 5.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TTGTCATTTTCGTCAATGATG	0.458													53	90					0	0	0.003610	0	0
LSM6	11157	broad.mit.edu	37	4	147108513	147108513	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:147108513G>A	uc003ikq.3	+	3	321	c.182G>A	c.(181-183)GGG>GAG	p.G61E	LSM6_uc003ikp.3_RNA	NM_007080	NP_009011	P62312	LSM6_HUMAN	Sm protein F	61					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA processing|RNA splicing|rRNA processing|tRNA processing	cytosol|small nuclear ribonucleoprotein complex	protein binding|RNA binding				0	all_hematologic(180;0.151)					AATAAGTATGGGGATGCATTT	0.413													8	22					0	0	0.003080	0	0
NR3C2	4306	broad.mit.edu	37	4	149075791	149075791	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:149075791G>A	uc003ilj.3	-	5	2610	c.2276C>T	c.(2275-2277)CCA>CTA	p.P759L	NR3C2_uc003ilk.3_Intron|NR3C2_uc010iph.2_Intron	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	759	Steroid-binding.		P -> S (in AD-PHA1).		regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGCTGTATCTGGTTTTGAGCT	0.493													63	79					0	0	0.003610	0	0
FGG	2266	broad.mit.edu	37	4	155528085	155528085	+	Missense_Mutation	SNP	G	A	A	rs121913087		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:155528085G>A	uc003ioj.2	-	8	1042	c.901C>T	c.(901-903)CGC>TGC	p.R301C	FGG_uc003iog.2_Missense_Mutation_p.R301C|FGG_uc003ioh.2_Missense_Mutation_p.R309C|FGG_uc010ipx.2_Missense_Mutation_p.R129C|FGG_uc010ipy.2_Missense_Mutation_p.R12C|FGG_uc003ioi.2_Missense_Mutation_p.R12C|FGG_uc003iok.2_Missense_Mutation_p.R309C	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	301	Fibrinogen C-terminal.		R -> H (in Bergamo-2/Essen/Haifa/Osaka-3/ Perugia/Saga/Barcelona-3/Barcelona-4).|R -> C (in Tochigi/Osaka-2/Milano-5/ Villajoyosa).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TATGTTAGGCGGTACTTGTCA	0.478													28	53					0	0	0.001786	0	0
GLRB	2743	broad.mit.edu	37	4	158074155	158074155	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:158074155C>T	uc003ipj.2	+	9	1392	c.1190C>T	c.(1189-1191)ACT>ATT	p.T397I		NM_000824	NP_000815	P48167	GLRB_HUMAN	glycine receptor, beta isoform A precursor	397	Cytoplasmic (Probable).				nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			skin(2)	2	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	CATATTAGCACTTTGCAGGTA	0.408													7	8					0	0	0.001984	0	0
ODZ3	55714	broad.mit.edu	37	4	183721183	183721183	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:183721183C>T	uc003ivd.1	+	27	7816	c.7779C>T	c.(7777-7779)TTC>TTT	p.F2593F		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2593	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CGCGCAGGTTCGCGGACGTGG	0.692													4	6					0	0	0.000248	0	0
TLR3	7098	broad.mit.edu	37	4	187005174	187005174	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr4:187005174A>T	uc003iyq.2	+	4	2435	c.2334A>T	c.(2332-2334)GAA>GAT	p.E778D	TLR3_uc011ckz.1_Missense_Mutation_p.E501D|TLR3_uc003iyr.2_Missense_Mutation_p.E501D	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	778	Cytoplasmic (Potential).|TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		CTTCAATGGAAAAGGAAGACC	0.368													19	45					0	0	0.008871	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5240004	5240004	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:5240004C>T	uc003jdl.2	+	16	2627	c.2489C>T	c.(2488-2490)GCT>GTT	p.A830V	ADAMTS16_uc003jdk.1_Missense_Mutation_p.A830V	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	830	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						AACTTAATCGCTACTGGACCA	0.507													75	54					0	0	0.003610	0	0
CTNND2	1501	broad.mit.edu	37	5	11082931	11082931	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:11082931G>A	uc003jfa.1	-	16	2810	c.2665C>T	c.(2665-2667)CGA>TGA	p.R889*	CTNND2_uc010itt.2_Nonsense_Mutation_p.R798*|CTNND2_uc011cmy.1_Nonsense_Mutation_p.R552*|CTNND2_uc011cmz.1_Nonsense_Mutation_p.R456*|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Nonsense_Mutation_p.R481*	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	889	ARM 8.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TTCTCTTTTCGGACAGCGGCT	0.537													34	35					0	0	0.005524	0	0
DNAH5	1767	broad.mit.edu	37	5	13776728	13776728	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:13776728G>A	uc003jfd.2	-	55	9235	c.9193C>T	c.(9193-9195)CCT>TCT	p.P3065S		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3065	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCATTGGTAGGAAGGCACCTG	0.443									Kartagener_syndrome				40	46					0	0	0.007835	0	0
CDH6	1004	broad.mit.edu	37	5	31323206	31323206	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:31323206G>A	uc003jhe.1	+	12	2490	c.2164G>A	c.(2164-2166)GAA>AAA	p.E722K		NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	722	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						AAGGTTAAAGGAAAATGACAC	0.562													10	36					0	0	0.006214	0	0
C9	735	broad.mit.edu	37	5	39311416	39311416	+	Missense_Mutation	SNP	C	T	T	rs147710831		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:39311416C>T	uc003jlv.3	-	7	1023	c.934G>A	c.(934-936)GAT>AAT	p.D312N		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	312	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			AGCACAACATCGCGATTTCTC	0.368													23	64					0	0	0.002780	0	0
DAB2	1601	broad.mit.edu	37	5	39377257	39377257	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:39377257G>A	uc003jlx.2	-	12	2163	c.1632C>T	c.(1630-1632)GTC>GTT	p.V544V	DAB2_uc003jlw.2_Silent_p.V523V	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	544					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			TACCAAAAATGACGGGCTGAC	0.537											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	65					0	0	0.003163	0	0
C7	730	broad.mit.edu	37	5	40955600	40955600	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:40955600G>A	uc003jmh.2	+	10	1319	c.1205G>A	c.(1204-1206)CGA>CAA	p.R402Q	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	402	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AACAAAAGGCGATATTCTGCC	0.438													55	66					0	0	0.003610	0	0
RAD17	5884	broad.mit.edu	37	5	68677755	68677755	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:68677755C>T	uc003jwo.2	+	4	474	c.412C>T	c.(412-414)CCT>TCT	p.P138S	RAD17_uc003jwg.2_Missense_Mutation_p.P127S|RAD17_uc003jwh.2_Missense_Mutation_p.P127S|RAD17_uc003jwi.2_Missense_Mutation_p.P127S|RAD17_uc003jwj.2_Missense_Mutation_p.P127S|RAD17_uc003jwk.2_Missense_Mutation_p.P127S|RAD17_uc003jwl.2_Missense_Mutation_p.P127S|RAD17_uc003jwm.2_5'UTR|RAD17_uc003jwn.2_Missense_Mutation_p.P41S	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	138	ATP (Potential).				cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		AATAACAGGTCCTCCTGGATG	0.318								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					7	28					0	0	0.004482	0	0
MAP1B	4131	broad.mit.edu	37	5	71494859	71494859	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:71494859G>A	uc003kbw.3	+	5	5918	c.5677G>A	c.(5677-5679)GAG>AAG	p.E1893K	MAP1B_uc010iyw.1_Missense_Mutation_p.E1910K|MAP1B_uc010iyx.1_Missense_Mutation_p.E1767K|MAP1B_uc010iyy.1_Missense_Mutation_p.E1767K	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1893	MAP1B 1.					microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TGAGTCTTATGAGAAGACCAC	0.463													19	62					0	0	0.008871	0	0
SV2C	22987	broad.mit.edu	37	5	75591654	75591654	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:75591654C>T	uc003kei.1	+	9	1523	c.1389C>T	c.(1387-1389)TCC>TCT	p.S463S		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	463	Extracellular (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CTCTGCAGTCCGATGAATATG	0.373													69	55					0	0	0.003610	0	0
IQGAP2	10788	broad.mit.edu	37	5	75866439	75866439	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:75866439C>T	uc003kek.2	+	4	560	c.338C>T	c.(337-339)ACC>ATC	p.T113I		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	113	CH.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ACAGATAATACCGTCCAGTGG	0.443													47	42					0	0	0.003610	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101583122	101583122	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:101583122C>T	uc003knm.2	-	10	1932	c.1645G>A	c.(1645-1647)GAA>AAA	p.E549K		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	549	Kazal-like.|Extracellular (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		GTTTTCCTTTCAATACAGGAA	0.299													34	102					0	0	0.004878	0	0
C5orf48	389320	broad.mit.edu	37	5	125968322	125968322	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:125968322G>A	uc003kub.1	+	2	184	c.171G>A	c.(169-171)ATG>ATA	p.M57I		NM_207408	NP_997291	Q6ZNM6	CE048_HUMAN	hypothetical protein LOC389320	57										ovary(1)	1						AAGAAAACATGATATTCAGGA	0.303													6	20					0	0	0.001168	0	0
PCDHA4	56144	broad.mit.edu	37	5	140187544	140187544	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:140187544G>A	uc003lhi.2	+	1	873	c.772G>A	c.(772-774)GGA>AGA	p.G258R	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.G258R|PCDHA4_uc011daa.1_Missense_Mutation_p.G258R	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	258	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTTCCTAATGGAACATTGGT	0.373													14	49					0	0	0.002450	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562935	140562935	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:140562935G>A	uc003liv.2	+	1	1956	c.801G>A	c.(799-801)AGG>AGA	p.R267R	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	267	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTCCGCCAGGGATTTAGACG	0.478													46	38					0	0	0.003610	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146017869	146017869	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:146017869C>T	uc003loe.2	-	6	1260	c.735G>A	c.(733-735)GGG>GGA	p.G245G	PPP2R2B_uc010jgm.2_Silent_p.G234G|PPP2R2B_uc003log.3_Silent_p.G245G|PPP2R2B_uc003lof.3_Silent_p.G245G|PPP2R2B_uc003loi.3_Silent_p.G248G|PPP2R2B_uc003loh.3_Silent_p.G245G|PPP2R2B_uc003loj.3_Silent_p.G225G|PPP2R2B_uc003lok.3_Silent_p.G234G|PPP2R2B_uc011dbu.1_Silent_p.G251G|PPP2R2B_uc011dbv.1_Silent_p.G303G	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	245	WD 4.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCCGGATTGTCCCTTTGCTGC	0.582													19	37					0	0	0.001523	0	0
FAT2	2196	broad.mit.edu	37	5	150932928	150932928	+	Silent	SNP	C	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:150932928C>A	uc003lue.3	-	5	3979	c.3966G>T	c.(3964-3966)GGG>GGT	p.G1322G	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1322	Extracellular (Potential).|Cadherin 11.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGGTGGCTGCCCACTGTCTG	0.577													7	23					0.00198382	0.00297722	0.001984	1	0
CCNJL	79616	broad.mit.edu	37	5	159686747	159686747	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr5:159686747G>A	uc003lyb.1	-	5	708	c.456C>T	c.(454-456)CCC>CCT	p.P152P	CCNJL_uc011dee.1_Silent_p.P104P|CCNJL_uc003lyc.1_RNA|CCNJL_uc011def.1_Silent_p.P104P	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	152	Cyclin N-terminal.					nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTCCAACTTGGGGACGTGGT	0.567													23	66					0	0	0.003330	0	0
TMEM14B	81853	broad.mit.edu	37	6	10751440	10751440	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:10751440G>A	uc003mzk.3	+	4	339	c.175G>A	c.(175-177)GAT>AAT	p.D59N	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jor.2_Intron|TMEM14B_uc010jos.1_Intron	NM_030969	NP_112231	Q9NUH8	TM14B_HUMAN	transmembrane protein 14B isoform a	59						integral to membrane					0	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.135)				GCTGTATCAGGATCCAAGGAA	0.537													61	73					0	0	0.003610	0	0
RANBP9	10048	broad.mit.edu	37	6	13644842	13644842	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:13644842G>A	uc003nbb.2	-	6	1106	c.1047C>T	c.(1045-1047)ATC>ATT	p.I349I	RANBP9_uc003nba.2_Silent_p.I8I	NM_005493	NP_005484	Q96S59	RANB9_HUMAN	RAN binding protein 9	349					axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding			lung(1)|skin(1)	2	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			TCTGTGCCTGGATTTTGGTTC	0.428													26	114					0	0	0.004656	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045730	26045730	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:26045730C>T	uc003nfv.2	+	1	92	c.92C>T	c.(91-93)CCG>CTG	p.P31L	HIST1H2BB_uc003nfu.2_5'Flank	NM_003531	NP_003522	P68431	H31_HUMAN	histone cluster 1, H3c	31					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						AAGAGCGCTCCGGCCACCGGT	0.612													31	44					0	0	0.008361	0	0
OR2B2	81697	broad.mit.edu	37	6	27879786	27879786	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:27879786G>A	uc011dkw.1	-	1	312	c.312C>T	c.(310-312)TTC>TTT	p.F104F		NM_033057	NP_149046	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCAAGGCCAGGAAAATGAAAA	0.448													30	41					0	0	0.008361	0	0
ZNF187	7741	broad.mit.edu	37	6	28239966	28239967	+	Silent	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:28239966_28239967CC>TT	uc011dld.1	+	3	540_541	c.270_271CC>TT	c.(268-273)ATCCTG>ATTTTG	p.90_91IL>IL	ZNF187_uc011dlc.1_Silent_p.90_91IL>IL|ZNF187_uc003nku.3_Intron|ZNF187_uc003nkw.3_5'UTR|ZNF187_uc011dle.1_5'UTR|ZNF187_uc011dlf.1_Intron|ZNF187_uc011dlg.1_5'UTR	NM_001111039	NP_001104509	Q16670	ZN187_HUMAN	zinc finger protein 187 isoform b	90_91	SCAN box.				viral reproduction	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AGGAGCAGATCCTGGAGCTGCT	0.584													11	14					0	0	0.004672	0	0
TRIM31	11074	broad.mit.edu	37	6	30071529	30071529	+	Silent	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:30071529A>T	uc003npg.1	-	9	1172	c.1062T>A	c.(1060-1062)TCT>TCA	p.S354S	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	354						mitochondrion	ligase activity|zinc ion binding			lung(1)	1						ATGGGGCTGAAGAGTGGTGAT	0.547													82	137					0	0	0.003610	0	0
PPP1R10	5514	broad.mit.edu	37	6	30570277	30570277	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:30570277G>A	uc003nqn.1	-	19	2701	c.2149C>T	c.(2149-2151)CCT>TCT	p.P717S	PPP1R10_uc010jsc.1_Missense_Mutation_p.P371S	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	717	Gly-rich.				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						ggaggaggaggaggaggTTCG	0.607													24	32					0	0	0.002299	0	0
DHX16	8449	broad.mit.edu	37	6	30627338	30627338	+	Missense_Mutation	SNP	G	A	A	rs143108219		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:30627338G>A	uc003nqz.2	-	12	2130	c.1918C>T	c.(1918-1920)CGG>TGG	p.R640W	DHX16_uc003nqy.2_Missense_Mutation_p.R159W|DHX16_uc011dmo.1_Missense_Mutation_p.R580W	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	640	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						AGGAGCTCCCGGATTTTGGAG	0.612													13	22					0	0	0.001368	0	0
DDAH2	23564	broad.mit.edu	37	6	31696664	31696664	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:31696664C>T	uc003nwp.2	-	1	906	c.275G>A	c.(274-276)TGG>TAG	p.W92*	DDAH2_uc003nwq.2_Nonsense_Mutation_p.W92*	NM_013974	NP_039268	O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	92					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding				0					L-Citrulline(DB00155)	AGCGGGGCTCCAGGGCCGCGT	0.642													13	331					0	0	0.001855	0	0
C6orf27	80737	broad.mit.edu	37	6	31733506	31733506	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:31733506G>A	uc011dog.1	-	17	2779	c.2541C>T	c.(2539-2541)CTC>CTT	p.L847L		NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	847						extracellular region				ovary(3)	3						TGGCCGTGGTGAGGATCGGGT	0.607													187	251					0	0	0.003610	0	0
VARS	7407	broad.mit.edu	37	6	31747282	31747282	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:31747282G>A	uc003nxe.2	-	28	3743	c.3320C>T	c.(3319-3321)GCC>GTC	p.A1107V	C6orf27_uc011dog.1_5'Flank|C6orf27_uc003nxd.2_5'Flank|C6orf27_uc011doh.1_5'Flank|VARS_uc003nxf.1_Missense_Mutation_p.A44V	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1107					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	CAGCTCAAGGGCGGCTTCTGC	0.687													167	199					0	0	0.003610	0	0
TNXB	7148	broad.mit.edu	37	6	32049835	32049836	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:32049835_32049836GG>AA	uc003nzl.2	-	9	3915_3916	c.3713_3714CC>TT	c.(3712-3714)CCC>CTT	p.P1238L		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1325	Fibronectin type-III 5.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CGGCCGTGAGGGGGCCATACCG	0.574													156	243					0	0	0.004672	0	0
BRD2	6046	broad.mit.edu	37	6	32944456	32944456	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:32944456C>T	uc003ocn.3	+	7	2644	c.943C>T	c.(943-945)CCT>TCT	p.P315S	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Missense_Mutation_p.P315S|BRD2_uc003ocp.3_Missense_Mutation_p.P195S|BRD2_uc010juh.2_Missense_Mutation_p.P315S	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	315					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						ACGGCTTCCCCCTATGCGTAG	0.552													12	94					0	0	0.003163	0	0
SRPK1	6732	broad.mit.edu	37	6	35838101	35838101	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:35838101G>A	uc003olj.2	-	10	1071	c.948C>T	c.(946-948)CCC>CCT	p.P316P	SRPK1_uc011dtg.1_Silent_p.P300P|SRPK1_uc003olh.2_Silent_p.P209P|SRPK1_uc003oli.2_Silent_p.P209P	NM_003137	NP_003128	Q96SB4	SRPK1_HUMAN	SFRS protein kinase 1	316	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1						TCTCTTTCAAGGGTCTTTCAA	0.383													15	22					0	0	0.007413	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652161	36652161	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:36652161C>T	uc003omm.3	+	2	405	c.283C>T	c.(283-285)CCT>TCT	p.P95S	CDKN1A_uc011dtq.1_Missense_Mutation_p.P129S|CDKN1A_uc003oml.2_Missense_Mutation_p.P95S|CDKN1A_uc003omn.2_Missense_Mutation_p.P95S	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	95					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						AGGCAGGCGGCCTGGCACCTC	0.667									Multiple_Endocrine_Neoplasia_type_1				9	22					0	0	0.004482	0	0
FTSJD2	23070	broad.mit.edu	37	6	37438796	37438796	+	Splice_Site	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:37438796G>A	uc003ons.2	+	14	1759	c.1506_splice	c.e14-1	p.S502_splice		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2						mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TTTTCTTCTAGCCACTGTAGT	0.413													11	51					0	0	0.000978	0	0
GLP1R	2740	broad.mit.edu	37	6	39047370	39047370	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:39047370C>T	uc003ooj.3	+	11	1134	c.1074C>T	c.(1072-1074)CCC>CCT	p.P358P	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	358	Helical; Name=6; (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	CACTCATCCCCCTGCTGGGGA	0.567													37	70					0	0	0.004878	0	0
UBR2	23304	broad.mit.edu	37	6	42625842	42625842	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:42625842C>T	uc011dur.1	+	27	2953	c.2953C>T	c.(2953-2955)CAC>TAC	p.H985Y	UBR2_uc011dus.1_Missense_Mutation_p.H630Y|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	985					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CCTAGAAGTCCACAAAGACAT	0.368													106	144					0	0	0.003610	0	0
GPR116	221395	broad.mit.edu	37	6	46826901	46826901	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:46826901G>A	uc003oyo.3	-	17	3028	c.2739C>T	c.(2737-2739)ATC>ATT	p.I913I	GPR116_uc011dwj.1_Silent_p.I468I|GPR116_uc011dwk.1_Silent_p.I342I|GPR116_uc003oyp.3_Silent_p.I771I|GPR116_uc003oyq.3_Silent_p.I913I|GPR116_uc010jzi.1_Silent_p.I585I	NM_001098518	NP_001091988	Q8IZF2	GP116_HUMAN	G-protein coupled receptor 116 precursor	913	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|skin(1)	2			Lung(136;0.192)			TATTTTCCTGGATATCCTGGG	0.428													46	60					0	0	0.003610	0	0
GCLC	2729	broad.mit.edu	37	6	53370239	53370239	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:53370239G>A	uc003pbw.1	-	12	1734	c.1346C>T	c.(1345-1347)ACC>ATC	p.T449I	GCLC_uc003pbv.1_Missense_Mutation_p.T173I	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	449					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	GATCACTCTGGTGAGCAGTAC	0.393													11	12					0	0	0.001855	0	0
DDX43	55510	broad.mit.edu	37	6	74116114	74116114	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:74116114G>A	uc003pgw.2	+	7	1179	c.835G>A	c.(835-837)GGA>AGA	p.G279R	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	279	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						TGTGTTGCAAGGAATAGATCT	0.328													17	43					0	0	0.004990	0	0
GABRR1	2569	broad.mit.edu	37	6	89891630	89891630	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:89891630G>A	uc003pna.2	-	8	1398	c.943C>T	c.(943-945)CCC>TCC	p.P315S	GABRR1_uc011dzv.1_Missense_Mutation_p.P292S	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	315	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TTACCTAAGGGGACTCTGGCA	0.453													49	75					0	0	0.003610	0	0
C6orf167	253714	broad.mit.edu	37	6	97599701	97599701	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:97599701G>A	uc003ppb.2	-	23	3694	c.3428C>T	c.(3427-3429)GCC>GTC	p.A1143V	C6orf167_uc011eaf.1_Missense_Mutation_p.A1103V	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	1143					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CACTTGGCAGGCTTTTACCAT	0.458													29	174					0	0	0.002096	0	0
MCHR2	84539	broad.mit.edu	37	6	100368907	100368907	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:100368907C>T	uc003pqh.1	-	6	1247	c.932G>A	c.(931-933)GGA>GAA	p.G311E	MCHR2_uc003pqi.1_Missense_Mutation_p.G311E	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTGGAAATTTCCACTCAGCAG	0.443													52	94					0	0	0.003610	0	0
AKD1	221264	broad.mit.edu	37	6	109850223	109850223	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:109850223T>A	uc003ptn.2	-	29	3701	c.3624A>T	c.(3622-3624)AAA>AAT	p.K1208N	AKD1_uc011eat.1_Missense_Mutation_p.K287N	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	1208					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						CCTCCCTCCTTTTTTTATCTC	0.184													37	51					0	0	0.005524	0	0
SLC22A16	85413	broad.mit.edu	37	6	110768188	110768188	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:110768188C>T	uc003puf.2	-	3	606	c.539G>A	c.(538-540)GGA>GAA	p.G180E	SLC22A16_uc003pue.2_Missense_Mutation_p.G161E	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	180					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CACCCGGCGTCCTAGCCTGAA	0.433													28	45					0	0	0.008361	0	0
GPRC6A	222545	broad.mit.edu	37	6	117130776	117130776	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:117130776C>T	uc003pxj.1	-	2	221	c.199G>A	c.(199-201)GAA>AAA	p.E67K	GPRC6A_uc003pxk.1_Missense_Mutation_p.E67K|GPRC6A_uc003pxl.1_Missense_Mutation_p.E67K	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	67	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ACTGATATTTCAAAGCTGTTG	0.353													25	9					0	0	0.004656	0	0
THEMIS	387357	broad.mit.edu	37	6	128222009	128222009	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:128222009G>A	uc003qbi.2	-	2	388	c.69C>T	c.(67-69)ATC>ATT	p.I23I	THEMIS_uc011ebt.1_Silent_p.I23I|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	23	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TGCCTGCCTGGATTTCTAGAA	0.448													52	23					0	0	0.003610	0	0
LAMA2	3908	broad.mit.edu	37	6	129636770	129636770	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:129636770G>A	uc003qbn.2	+	25	3810	c.3705G>A	c.(3703-3705)TGG>TGA	p.W1235*	LAMA2_uc003qbo.2_Nonsense_Mutation_p.W1235*	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1235	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTTTTTATTGGAAACTTCCAG	0.388													39	16					0	0	0.002852	0	0
TMEM200A	114801	broad.mit.edu	37	6	130761987	130761987	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:130761987C>T	uc003qca.2	+	3	1291	c.420C>T	c.(418-420)TTC>TTT	p.F140F	TMEM200A_uc010kfh.2_Silent_p.F140F|TMEM200A_uc010kfi.2_Silent_p.F140F|TMEM200A_uc003qcb.2_Silent_p.F140F	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	140	Helical; (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TTTTCATTTTCATTTGTGCTA	0.413													25	7					0	0	0.003330	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151152185	151152185	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:151152185T>A	uc003qny.1	+	16	2250	c.1938T>A	c.(1936-1938)TTT>TTA	p.F646L	PLEKHG1_uc011eel.1_Missense_Mutation_p.F686L|PLEKHG1_uc011eem.1_Missense_Mutation_p.F705L|PLEKHG1_uc003qnz.2_Missense_Mutation_p.F646L	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	646					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TGACTCCCTTTGGGTCATCCA	0.458													20	12					0	0	0.007413	0	0
SYNE1	23345	broad.mit.edu	37	6	152576738	152576738	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:152576738G>A	uc010kiw.2	-	103	19850	c.19248C>T	c.(19246-19248)CTC>CTT	p.L6416L	SYNE1_uc010kiv.2_Silent_p.L940L|SYNE1_uc003qos.3_Silent_p.L940L|SYNE1_uc003qot.3_Silent_p.L6345L|SYNE1_uc003qou.3_Silent_p.L6416L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6416	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTGGTTGAAGAGACAAGTCT	0.383										HNSCC(10;0.0054)			26	34					0	0	0.004656	0	0
TIAM2	26230	broad.mit.edu	37	6	155578089	155578089	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:155578089G>A	uc003qqb.2	+	29	6213	c.4940G>A	c.(4939-4941)GGA>GAA	p.G1647E	TIAM2_uc003qqe.2_Missense_Mutation_p.G1647E|TIAM2_uc010kjj.2_Missense_Mutation_p.G1209E|TIAM2_uc003qqf.2_Missense_Mutation_p.G1023E|TIAM2_uc011efl.1_Missense_Mutation_p.G991E|TIAM2_uc003qqg.2_Missense_Mutation_p.G959E|TIAM2_uc003qqh.2_Missense_Mutation_p.G572E|uc003qqi.1_5'Flank	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	1647					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AGGGACAGAGGAACTTTGCTC	0.532													15	8					0	0	0.002450	0	0
THBS2	7058	broad.mit.edu	37	6	169639732	169639732	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr6:169639732G>A	uc003qwt.2	-	8	1339	c.1091C>T	c.(1090-1092)TCC>TTC	p.S364F		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	364	VWFC.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TTCCACAAAGGATGGACTGGC	0.483													12	4					0	0	0.002450	0	0
SUN1	23353	broad.mit.edu	37	7	881763	881763	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:881763C>T	uc011jvp.1	+	4	526	c.447C>T	c.(445-447)TTC>TTT	p.F149F	SUN1_uc010ksa.1_Silent_p.F170F|SUN1_uc003sje.1_Silent_p.F149F|SUN1_uc003sjf.2_Silent_p.F99F|SUN1_uc011jvq.1_Silent_p.F149F|SUN1_uc003sjg.2_5'Flank	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	149	Nuclear.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						TGGACCACTTCTGGGGTGAGT	0.587													23	15					0	0	0.004656	0	0
TNRC18	84629	broad.mit.edu	37	7	5348769	5348769	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:5348769C>T	uc003soi.3	-	28	8968	c.8619G>A	c.(8617-8619)CAG>CAA	p.Q2873Q		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	2873	BAH.						DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		TCACCTGGCCCTGGTGGAACT	0.672													6	4					0	0	0.001168	0	0
PDE1C	5137	broad.mit.edu	37	7	31862790	31862790	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:31862790C>T	uc003tcm.1	-	14	1948	c.1479G>A	c.(1477-1479)CCG>CCA	p.P493P	PDE1C_uc003tcn.1_Silent_p.P493P|PDE1C_uc003tco.1_Silent_p.P553P|PDE1C_uc003tcr.2_Silent_p.P493P|PDE1C_uc003tcs.2_Silent_p.P493P	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	493	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AATTGTTGATCGGGGCACTTC	0.468													21	67					0	0	0.001523	0	0
RP9	6100	broad.mit.edu	37	7	33139017	33139017	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:33139017G>C	uc003tdm.2	-	3	233	c.215C>G	c.(214-216)CCA>CGA	p.P72R		NM_203288	NP_976033	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9	72	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)			TGGTACATCTGGTATGCAATC	0.483													3	95					0	0	0.004672	0	0
GLI3	2737	broad.mit.edu	37	7	42088243	42088243	+	Missense_Mutation	SNP	T	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:42088243T>C	uc011kbh.1	-	5	617	c.526A>G	c.(526-528)ATC>GTC	p.I176V	GLI3_uc011kbg.1_Missense_Mutation_p.I117V	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	176					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						TGTGGGGAGATCCTAATGAAG	0.512									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				20	56					0	0	0.007413	0	0
PCLO	27445	broad.mit.edu	37	7	82580169	82580169	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:82580169G>A	uc003uhx.2	-	6	10024	c.9735C>T	c.(9733-9735)TTC>TTT	p.F3245F	PCLO_uc003uhv.2_Silent_p.F3245F|PCLO_uc010lec.2_Silent_p.F210F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3176	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CTTGTTCTCGGAACCTTTGAA	0.473													67	43					0	0	0.003610	0	0
MGC26647	219557	broad.mit.edu	37	7	88424233	88424233	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:88424233C>T	uc003ujv.2	-	2	206	c.24G>A	c.(22-24)CAG>CAA	p.Q8Q	ZNF804B_uc011khi.1_Intron	NM_152706	NP_689919	Q8TBZ9	CG062_HUMAN	hypothetical protein LOC219557	8											0	Esophageal squamous(14;0.00802)|all_hematologic(106;0.109)|Lung NSC(181;0.168)|all_lung(186;0.169)		STAD - Stomach adenocarcinoma(171;0.229)			TGCTGCCCTTCTGGTTATGGA	0.423													28	102					0	0	0.001786	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762252	92762252	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:92762252A>G	uc003umh.1	-	5	4249	c.3033T>C	c.(3031-3033)ATT>ATC	p.I1011I	SAMD9L_uc003umj.1_Silent_p.I1011I|SAMD9L_uc003umi.1_Silent_p.I1011I|SAMD9L_uc010lfb.1_Silent_p.I1011I|SAMD9L_uc003umk.1_Silent_p.I1011I|SAMD9L_uc010lfc.1_Silent_p.I1011I|SAMD9L_uc010lfd.1_Silent_p.I1011I|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1011										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TATTCAATGCAATTTGACATT	0.363													26	51					0	0	0.003330	0	0
PUS7	54517	broad.mit.edu	37	7	105135651	105135651	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:105135651G>A	uc003vcx.2	-	6	999	c.780C>T	c.(778-780)TTC>TTT	p.F260F	PUS7_uc010lji.2_Silent_p.F266F|PUS7_uc003vcy.2_Silent_p.F260F|PUS7_uc003vcz.1_Silent_p.F260F	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	260					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						TATATAGTACGAAGTGGCAGT	0.318													38	131					0	0	0.006999	0	0
PIK3CG	5294	broad.mit.edu	37	7	106522626	106522626	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:106522626G>A	uc003vdv.3	+	7	2688	c.2603G>A	c.(2602-2604)GGT>GAT	p.G868D	PIK3CG_uc003vdu.2_Missense_Mutation_p.G868D|PIK3CG_uc003vdw.2_Missense_Mutation_p.G868D	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	868	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CTGCCATATGGTTGCATTTCA	0.378													24	33					0	0	0.004656	0	0
SLC26A4	5172	broad.mit.edu	37	7	107329560	107329560	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:107329560C>T	uc003vep.2	+	9	1288	c.1064C>T	c.(1063-1065)TCC>TTC	p.S355F	SLC26A4_uc011kmb.1_5'Flank|SLC26A4_uc011kmc.1_5'Flank	NM_000441	NP_000432	O43511	S26A4_HUMAN	pendrin	355	Helical; (Potential).				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)	7						GCATCATTTTCCATCGCTGTG	0.448									Pendred_syndrome				32	97					0	0	0.002445	0	0
KCND2	3751	broad.mit.edu	37	7	120373061	120373061	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:120373061C>T	uc003vjj.1	+	2	2185	c.1220C>T	c.(1219-1221)TCC>TTC	p.S407F		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	407	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GTGATTGTATCCAACTTCAGT	0.483													14	37					0	0	0.001855	0	0
WASL	8976	broad.mit.edu	37	7	123334878	123334878	+	Silent	SNP	A	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:123334878A>G	uc003vkz.2	-	8	1045	c.717T>C	c.(715-717)TGT>TGC	p.C239C		NM_003941	NP_003932	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome gene-like protein	239					actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity				0						CTGAGATTCCACACATATCGA	0.299													40	158					0	0	0.002522	0	0
CPA1	1357	broad.mit.edu	37	7	130025088	130025088	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:130025088G>A	uc003vpx.2	+	8	961	c.889G>A	c.(889-891)GGG>AGG	p.G297R	CPA1_uc003vpw.2_Missense_Mutation_p.G131R	NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	297					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					GAAGGACCATGGGAACATCAA	0.527													19	52					0	0	0.007413	0	0
SVOPL	136306	broad.mit.edu	37	7	138312160	138312160	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:138312160C>T	uc011kqh.1	-	11	1116	c.1116G>A	c.(1114-1116)CTG>CTA	p.L372L	SVOPL_uc003vue.2_Silent_p.L220L	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	372						integral to membrane	transmembrane transporter activity				0						TAGAAAGGCTCAGCCGTCTTC	0.398													7	21					0	0	0.004482	0	0
ZC3HAV1L	92092	broad.mit.edu	37	7	138713678	138713678	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:138713678G>A	uc003vum.1	-	3	542	c.530C>T	c.(529-531)GCC>GTC	p.A177V		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	177											0						GCCATACAGGGCTTCCCCTTT	0.358													11	26					0	0	0.008291	0	0
DENND2A	27147	broad.mit.edu	37	7	140301292	140301292	+	Silent	SNP	T	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:140301292T>G	uc010lnj.2	-	1	1051	c.906A>C	c.(904-906)CTA>CTC	p.L302L	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.L302L|DENND2A_uc003vvw.2_Silent_p.L302L|DENND2A_uc003vvx.2_Silent_p.L302L	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	302										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					gcgggggaggtagagagggca	0.388													8	45					0	0	0.001882	0	0
MGAM	8972	broad.mit.edu	37	7	141752634	141752634	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:141752634C>T	uc003vwy.2	+	26	3063	c.3009C>T	c.(3007-3009)TAC>TAT	p.Y1003Y		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1003	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACGACCTATACTCTGTCAGTG	0.458													33	116					0	0	0.005524	0	0
CLCN1	1180	broad.mit.edu	37	7	143018840	143018840	+	Missense_Mutation	SNP	C	T	T	rs143506735		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:143018840C>T	uc003wcr.1	+	5	682	c.595C>T	c.(595-597)CGT>TGT	p.R199C	CLCN1_uc011ktc.1_5'UTR|CLCN1_uc003wcs.1_RNA|CLCN1_uc010lox.1_RNA|CLCN1_uc010loy.1_Missense_Mutation_p.R47C	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	199					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GACAATACTTCGTGGGGTTGT	0.507													23	58					0	0	0.002780	0	0
OR2F1	26211	broad.mit.edu	37	7	143657601	143657601	+	Missense_Mutation	SNP	G	A	A	rs112027056		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:143657601G>A	uc003wds.1	+	1	582	c.538G>A	c.(538-540)GAA>AAA	p.E180K		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					CATATCCTGTGAACTCCTAGC	0.502													42	28					0	0	0.007835	0	0
OR2A25	392138	broad.mit.edu	37	7	143771642	143771642	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:143771642A>T	uc011ktx.1	+	1	330	c.330A>T	c.(328-330)GAA>GAT	p.E110D		NM_001004488	NP_001004488	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					CACATACAGAATGTCTCCTCC	0.512													34	62					0	0	0.002836	0	0
OR2A12	346525	broad.mit.edu	37	7	143793069	143793069	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:143793069G>A	uc011kty.1	+	1	869	c.869G>A	c.(868-870)AGC>AAC	p.S290N		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	290	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					CTCATCTACAGCCTTAGGAAT	0.463													85	238					0	0	0.003610	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144075892	144075893	+	Nonsense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr7:144075892_144075893CC>TT	uc003wel.2	+	14	4687_4688	c.4569_4570CC>TT	c.(4567-4572)CCCCGA>CCTTGA	p.R1524*	ARHGEF5_uc003wem.2_Nonsense_Mutation_p.R325*	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1524	SH3.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					CCTACAAGCCCCGAGAGAATGA	0.569													36	124					0	0	0.004672	0	0
MYOM2	9172	broad.mit.edu	37	8	2057234	2057234	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:2057234G>A	uc003wpx.3	+	25	3230	c.3092G>A	c.(3091-3093)CGG>CAG	p.R1031Q	MYOM2_uc011kwi.1_Missense_Mutation_p.R456Q	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1031					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GATAAGGGGCGGGTTCGCTTC	0.443													28	22					0	0	0.006320	0	0
CSMD1	64478	broad.mit.edu	37	8	2836281	2836281	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:2836281G>A	uc011kwk.1	-	55	8812	c.8422C>T	c.(8422-8424)CGT>TGT	p.R2808C	CSMD1_uc011kwj.1_Missense_Mutation_p.R2137C|CSMD1_uc010lrg.2_Missense_Mutation_p.R818C	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2808	Extracellular (Potential).|Sushi 20.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCCCGTGACGAATGGCATTT	0.403													15	7					0	0	0.006122	0	0
CSMD1	64478	broad.mit.edu	37	8	3245065	3245065	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:3245065G>A	uc011kwk.1	-	18	3126	c.2736C>T	c.(2734-2736)CTC>CTT	p.L912L	CSMD1_uc011kwj.1_Silent_p.L304L|CSMD1_uc003wqe.2_Silent_p.L68L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	912	Extracellular (Potential).|Sushi 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCTCACAGACGAGGGGCTCGT	0.602													10	4					0	0	0.006214	0	0
MSRA	4482	broad.mit.edu	37	8	10285790	10285791	+	Missense_Mutation	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:10285790_10285791GG>AA	uc003wsx.2	+	6	873_874	c.676_677GG>AA	c.(676-678)GGC>AAC	p.G226N	MSRA_uc011kwx.1_Missense_Mutation_p.G186N|MSRA_uc003wsz.2_Missense_Mutation_p.G183N|MSRA_uc003wsy.2_Missense_Mutation_p.G160N	NM_012331	NP_036463	Q9UJ68	MSRA_HUMAN	methionine sulfoxide reductase A isoform a	226					methionine metabolic process|protein modification process|response to oxidative stress	mitochondrion|nucleus	peptide-methionine-(S)-S-oxide reductase activity				0		Myeloproliferative disorder(644;0.178)			L-Methionine(DB00134)	TGGGGGCACCGGCGTGTCCTGC	0.515													34	30					0	0	0.004672	0	0
ENTPD4	9583	broad.mit.edu	37	8	23294584	23294584	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:23294584G>A	uc003xdl.2	-	10	1401	c.1237C>T	c.(1237-1239)CTC>TTC	p.L413F	ENTPD4_uc011kzu.1_Missense_Mutation_p.L405F|ENTPD4_uc003xdm.2_Missense_Mutation_p.L405F|ENTPD4_uc011kzv.1_Missense_Mutation_p.L413F	NM_004901	NP_004892	Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	413	Lumenal (Potential).				UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			ovary(1)|kidney(1)	2		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		ACCCCATTGAGGGAAGTCTGG	0.478													50	56					0	0	0.003610	0	0
KCNU1	157855	broad.mit.edu	37	8	36793381	36793381	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:36793381G>A	uc010lvw.2	+	27	3480	c.3393G>A	c.(3391-3393)AGG>AGA	p.R1131R		NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1131	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AAAATGAAAGGAAAACTTCAG	0.383													47	42					0	0	0.003610	0	0
RNF5P1	286140	broad.mit.edu	37	8	38458541	38458541	+	Missense_Mutation	SNP	G	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:38458541G>C	uc003xly.2	-	1	235	c.178C>G	c.(178-180)CGG>GGG	p.R60G		NR_003129				SubName: Full=Putative uncharacterized protein RNF5;												0						CACTCTTGCCGTTCTGGCCGT	0.532													8	237					0	0	0.004482	0	0
ADAM18	8749	broad.mit.edu	37	8	39467023	39467023	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:39467023G>A	uc003xni.2	+	5	287	c.287G>A	c.(286-288)GGA>GAA	p.G96E	ADAM18_uc003xnh.2_Missense_Mutation_p.G96E|ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.G96E	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	96					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CATTACCAAGGATATGCTGCC	0.328													13	27					0	0	0.002450	0	0
ANK1	286	broad.mit.edu	37	8	41552247	41552247	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:41552247C>G	uc003xok.2	-	28	3274	c.3190G>C	c.(3190-3192)GTG>CTG	p.V1064L	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.V380L|ANK1_uc003xoi.2_Missense_Mutation_p.V1064L|ANK1_uc003xoj.2_Missense_Mutation_p.V1064L|ANK1_uc003xol.2_Missense_Mutation_p.V1064L|ANK1_uc003xom.2_Missense_Mutation_p.V1105L	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1064					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GACATGATCACGAAGTACAGC	0.602													33	19					0	0	0.003271	0	0
HGSNAT	138050	broad.mit.edu	37	8	43046651	43046651	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:43046651C>T	uc003xpx.3	+	12	1211	c.1163C>T	c.(1162-1164)TCC>TTC	p.S388F		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	416	Cytoplasmic (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			GACATCACGTCCAGCTGGCCC	0.557													96	86					0	0	0.003610	0	0
PREX2	80243	broad.mit.edu	37	8	68989633	68989633	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:68989633G>A	uc003xxv.1	+	15	1598	c.1571G>A	c.(1570-1572)GGA>GAA	p.G524E	PREX2_uc003xxu.1_Missense_Mutation_p.G524E|PREX2_uc011lez.1_Missense_Mutation_p.G459E	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	524	DEP 2.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GGTTAACAGGGAGATTGCCGC	0.448													14	63					0	0	0.002450	0	0
SULF1	23213	broad.mit.edu	37	8	70513987	70513987	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:70513987G>A	uc010lza.1	+	10	1701	c.984G>A	c.(982-984)AAG>AAA	p.K328K	SULF1_uc003xyd.2_Silent_p.K328K|SULF1_uc003xye.2_Silent_p.K328K|SULF1_uc003xyf.2_Silent_p.K328K|SULF1_uc003xyg.2_Silent_p.K328K|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	328					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			GACTGGTCAAGGGGAAATCCA	0.448													48	126					0	0	0.003610	0	0
KCNB2	9312	broad.mit.edu	37	8	73848346	73848346	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:73848346C>T	uc003xzb.2	+	3	1344	c.756C>T	c.(754-756)TTC>TTT	p.F252F		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	252	Helical; Name=Segment S2; (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTTTGCGATTCTTATCCTCAC	0.443													27	63					0	0	0.004656	0	0
DPYS	1807	broad.mit.edu	37	8	105459605	105459605	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:105459605C>T	uc003yly.3	-	3	679	c.550G>A	c.(550-552)GAA>AAA	p.E184K		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	184					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GCTCCAATTTCCTTGCACCGA	0.443													12	44					0	0	0.001855	0	0
OXR1	55074	broad.mit.edu	37	8	107705019	107705019	+	Nonsense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:107705019C>T	uc011lht.1	+	6	691	c.592C>T	c.(592-594)CGA>TGA	p.R198*	OXR1_uc003ymf.2_Nonsense_Mutation_p.R197*|OXR1_uc011lhu.1_Nonsense_Mutation_p.R190*|OXR1_uc010mcg.2_Intron|OXR1_uc003ymg.1_Nonsense_Mutation_p.R130*|OXR1_uc003ymi.1_Nonsense_Mutation_p.R109*	NM_018002	NP_060472	Q8N573	OXR1_HUMAN	oxidation resistance 1 isoform 1	198					cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion					0			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TCGACCTGCACGAGTTGTATC	0.348													13	46					0	0	0.003163	0	0
TRHR	7201	broad.mit.edu	37	8	110131468	110131468	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:110131468C>T	uc003ymz.3	+	2	997	c.981C>T	c.(979-981)TTC>TTT	p.F327F		NM_003301	NP_003292	P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	327	Cytoplasmic (Potential).					integral to plasma membrane	thyrotropin-releasing hormone receptor activity			skin(2)|lung(1)	3			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			CCCAGAAATTCCGTGCAGCCT	0.443													36	98					0	0	0.003755	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110437414	110437414	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:110437414C>T	uc003yne.2	+	24	2902	c.2798C>T	c.(2797-2799)CCT>CTT	p.P933L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	933	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCATCTCCACCTCTAAGTGGC	0.348										HNSCC(38;0.096)			8	20					0	0	0.003080	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110460435	110460435	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:110460435C>T	uc003yne.2	+	39	5944	c.5840C>T	c.(5839-5841)TCC>TTC	p.S1947F		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1947	Extracellular (Potential).|IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTGGAAATCTCCGTGATGATA	0.393										HNSCC(38;0.096)			7	20					0	0	0.003080	0	0
CSMD3	114788	broad.mit.edu	37	8	114111073	114111073	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:114111073C>T	uc003ynu.2	-	5	988	c.829G>A	c.(829-831)GAC>AAC	p.D277N	CSMD3_uc003ynt.2_Missense_Mutation_p.D237N|CSMD3_uc011lhx.1_Missense_Mutation_p.D277N|CSMD3_uc010mcx.1_Missense_Mutation_p.D277N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	277	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GAAATTGTGTCCCCAGGCTCT	0.388										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	27					0	0	0.002450	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428248	128428248	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:128428248G>A	uc003ysf.2	+	1	392	c.137G>A	c.(136-138)GGA>GAA	p.G46E	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_RNA	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	46						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGAGGGCCAGGAATCGGGCCG	0.692													8	2					0	0	0.000978	0	0
ADCY8	114	broad.mit.edu	37	8	131848589	131848589	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:131848589G>A	uc003ytd.3	-	12	2865	c.2609C>T	c.(2608-2610)GCC>GTC	p.A870V	ADCY8_uc010mds.2_Missense_Mutation_p.A739V	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	870	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGTGAGCAGGGCATAGATGGC	0.557										HNSCC(32;0.087)			49	43					0	0	0.003610	0	0
EFR3A	23167	broad.mit.edu	37	8	132991155	132991155	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:132991155C>T	uc003yte.2	+	13	1589	c.1388C>T	c.(1387-1389)CCT>CTT	p.P463L		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	463						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TTCCTGGATCCTTTGTTATCA	0.428													20	59					0	0	0.007413	0	0
GLI4	2738	broad.mit.edu	37	8	144358717	144358717	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:144358717G>A	uc003yxx.2	+	4	959	c.874G>A	c.(874-876)GAG>AAG	p.E292K	ZFP41_uc003yxv.2_RNA	NM_138465	NP_612474	P10075	GLI4_HUMAN	GLI-Kruppel family member GLI4	292						nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)			GCACACGGGTGAGAAGCCCTA	0.657													8	8					0	0	0.003080	0	0
ZDHHC21	340481	broad.mit.edu	37	9	14639895	14639895	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:14639895G>A	uc003zli.2	-	8	1090	c.620C>T	c.(619-621)ACA>ATA	p.T207I	ZDHHC21_uc003zlg.1_Intron	NM_178566	NP_848661	Q8IVQ6	ZDH21_HUMAN	zinc finger, DHHC-type containing 21	207					nitric oxide metabolic process|regulation of nitric-oxide synthase activity	Golgi membrane|integral to membrane	palmitoyltransferase activity|zinc ion binding				0				GBM - Glioblastoma multiforme(50;4.31e-06)		TATACTTACTGTGATGATGCC	0.299													20	10					0	0	0.001523	0	0
DENND4C	55667	broad.mit.edu	37	9	19346844	19346844	+	Missense_Mutation	SNP	C	G	G			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:19346844C>G	uc003znq.2	+	18	3255	c.3222C>G	c.(3220-3222)TTC>TTG	p.F1074L	DENND4C_uc011lnc.1_Missense_Mutation_p.F404L|DENND4C_uc011lnd.1_Missense_Mutation_p.F362L|DENND4C_uc003znr.2_Missense_Mutation_p.F362L|DENND4C_uc003zns.2_Missense_Mutation_p.F256L|DENND4C_uc003znt.2_Missense_Mutation_p.F256L	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1074						integral to membrane				ovary(1)|skin(1)	2						CTGGGCGTTTCAAGCAGCAAA	0.463													39	27					0	0	0.006230	0	0
MTAP	4507	broad.mit.edu	37	9	21816739	21816739	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:21816739G>A	uc003zph.2	+	3	260	c.147G>A	c.(145-147)AAG>AAA	p.K49K	MTAP_uc003zpi.1_Silent_p.K49K|MTAP_uc010mit.2_RNA|MTAP_uc011lnk.1_Silent_p.K66K|MTAP_uc011lnl.1_5'Flank	NM_002451	NP_002442	Q13126	MTAP_HUMAN	5'-methylthioadenosine phosphorylase	49					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity			central_nervous_system(1)	1		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	TTTTGGGGAAGATAAAAAATG	0.303													90	28					0	0	0.003610	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971208	21971208	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:21971208C>T	uc003zpk.2	-	2	363	c.151_splice	c.e2-1	p.V51_splice	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Splice_Site|CDKN2A_uc010miu.2_Splice_Site|CDKN2A_uc003zpl.2_Splice_Site_p.G106_splice	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1						cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(28)|p.V28_V51del(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TCATCATGACCTGCCAGAGAG	0.667		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			37	22					0	0	0.004289	0	0
FOXD4L5	653427	broad.mit.edu	37	9	70177128	70177128	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:70177128C>T	uc010moc.2	-	1	1688	c.856G>A	c.(856-858)GAA>AAA	p.E286K		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	286					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						TCCGCGCCTTCTGCTTTCTTC	0.687													36	48					0	0	0.003610	0	0
S1PR3	1903	broad.mit.edu	37	9	91616371	91616371	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:91616371C>T	uc004aqe.2	+	2	652	c.256C>T	c.(256-258)CTG>TTG	p.L86L		NM_005226	NP_005217	Q99500	S1PR3_HUMAN	sphingosine-1-phosphate receptor 3	86	Helical; Name=2; (By similarity).				anatomical structure morphogenesis|elevation of cytosolic calcium ion concentration|inflammatory response|positive regulation of cell proliferation	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)|central_nervous_system(1)|skin(1)	5						TCTCTGCGACCTGCTGGCCGG	0.493											OREG0019291	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	74	22					0	0	0.003610	0	0
TEX10	54881	broad.mit.edu	37	9	103111476	103111476	+	Missense_Mutation	SNP	A	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:103111476A>C	uc004bas.2	-	2	385	c.170T>G	c.(169-171)CTT>CGT	p.L57R	TEX10_uc011lvf.1_5'Flank|TEX10_uc011lvg.1_Missense_Mutation_p.L60R|TEX10_uc011lvh.1_Intron|TEX10_uc004bat.2_Missense_Mutation_p.L57R	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	57						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CTTTATGTTAAGTTTTCTATT	0.289													20	13					0	0	0.001523	0	0
ALDOB	229	broad.mit.edu	37	9	104192063	104192064	+	Missense_Mutation	DNP	CC	TT	TT			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:104192063_104192064CC>TT	uc004bbk.2	-	3	379_380	c.297_298GG>AA	c.(295-300)AAGGAA>AAAAAA	p.E100K		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	100					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding	p.K99K(1)		skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				ATCCCCTTTTCCTTGAGGATGT	0.53													127	183					0	0	0.004672	0	0
DBC1	1620	broad.mit.edu	37	9	121929549	121929549	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:121929549C>T	uc004bkc.2	-	8	2555	c.2099G>A	c.(2098-2100)CGG>CAG	p.R700Q		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	700					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						AATTCGGTCCCGAATATCCAA	0.572													30	128					0	0	0.006320	0	0
C5	727	broad.mit.edu	37	9	123742513	123742514	+	Missense_Mutation	DNP	AT	GC	GC			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:123742513_123742514AT>GC	uc004bkv.2	-	28	3535_3536	c.3505_3506AT>GC	c.(3505-3507)ATT>GCT	p.I1169A		NM_001735	NP_001726	P01031	CO5_HUMAN	complement component 5 preproprotein	1169					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	GTCAGCTTTAATTAGAGCTGTG	0.416													24	43					0	0	0.004672	0	0
PKN3	29941	broad.mit.edu	37	9	131476863	131476863	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:131476863C>T	uc004bvw.2	+	12	1897	c.1504C>T	c.(1504-1506)CCC>TCC	p.P502S	PKN3_uc010myh.2_Missense_Mutation_p.P502S|PKN3_uc011mbk.1_Missense_Mutation_p.P52S	NM_013355	NP_037487	Q6P5Z2	PKN3_HUMAN	protein kinase PKNbeta	502	Pro-rich.				signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			stomach(2)|lung(2)	4						CAAGAAGACCCCCTTGGGTGA	0.597													36	50					0	0	0.004289	0	0
SH3GLB2	56904	broad.mit.edu	37	9	131777152	131777152	+	Silent	SNP	T	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:131777152T>C	uc004bwv.2	-	4	512	c.366A>G	c.(364-366)GAA>GAG	p.E122E	SH3GLB2_uc004bww.2_Silent_p.E122E|SH3GLB2_uc004bwx.1_Silent_p.E122E|SH3GLB2_uc011mbm.1_Silent_p.E122E	NM_020145	NP_064530	Q9NR46	SHLB2_HUMAN	SH3-domain GRB2-like endophilin B2	122	BAR.|Potential.				filopodium assembly|signal transduction	cytoplasm|nucleus	cytoskeletal adaptor activity|SH3 domain binding				0						CCAGTTGCTTTTCAGCTTCTG	0.547													56	86					0	0	0.003610	0	0
FAM73B	84895	broad.mit.edu	37	9	131832549	131832549	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:131832549G>A	uc004bxa.2	+	16	1785	c.1599G>A	c.(1597-1599)AGG>AGA	p.R533R	FAM73B_uc004bwy.2_RNA|FAM73B_uc004bwz.2_RNA|FAM73B_uc004bxb.2_Silent_p.R109R	NM_032809	NP_116198	Q7L4E1	FA73B_HUMAN	hypothetical protein LOC84895	533						integral to membrane				skin(1)	1						AGTACCTGAGGGACATGTTCG	0.642													23	67					0	0	0.008361	0	0
BAT2L1	84726	broad.mit.edu	37	9	134363292	134363292	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:134363292C>T	uc004can.3	+	27	6089	c.6034C>T	c.(6034-6036)CTC>TTC	p.L2012F	BAT2L1_uc004cao.3_Missense_Mutation_p.L1369F|BAT2L1_uc004cap.3_Missense_Mutation_p.L157F|SNORD62A_uc004car.2_5'Flank|BAT2L1_uc011mch.1_5'Flank	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	2012							protein binding				0						CACCATGATCCTCTCTGGGGG	0.607													10	45					0	0	0.008291	0	0
COL5A1	1289	broad.mit.edu	37	9	137659200	137659200	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:137659200G>A	uc004cfe.2	+	24	2614	c.2232G>A	c.(2230-2232)AAG>AAA	p.K744K		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	744	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CAGGAGAAAAGGTAGGTGGGC	0.612													11	36					0	0	0.001368	0	0
FUT7	2529	broad.mit.edu	37	9	139925179	139925179	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:139925179C>T	uc004ckq.2	-	2	1861	c.1012G>A	c.(1012-1014)GGT>AGT	p.G338S	ABCA2_uc011mel.1_5'Flank|ABCA2_uc011mem.1_5'Flank|ABCA2_uc004ckl.1_5'Flank|ABCA2_uc004ckm.1_5'Flank|C9orf139_uc004ckp.1_Intron	NM_004479	NP_004470	Q11130	FUT7_HUMAN	fucosyltransferase 7	338	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		TGAAACCAACCCTCAAGGTCC	0.627													16	31					0	0	0.008871	0	0
ANAPC2	29882	broad.mit.edu	37	9	140079372	140079372	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:140079372G>A	uc004clr.1	-	4	1114	c.1041C>T	c.(1039-1041)ATC>ATT	p.I347I	ANAPC2_uc004clq.1_Silent_p.I206I	NM_013366	NP_037498	Q9UJX6	ANC2_HUMAN	anaphase-promoting complex subunit 2	347					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			ovary(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		CACCTCGGACGATGCTGAAGA	0.677													21	43					0	0	0.004656	0	0
CACNA1B	774	broad.mit.edu	37	9	140878646	140878646	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:140878646C>T	uc004cog.2	+	13	1858	c.1713C>T	c.(1711-1713)TCC>TCT	p.S571S	CACNA1B_uc011mfd.1_Silent_p.S102S	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	571	Extracellular (Potential).|II.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CGGGAAGCTCCTTTGGGATCA	0.622													7	12					0	0	0.004482	0	0
ZBED1	9189	broad.mit.edu	37	X	2406965	2406965	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:2406965G>A	uc004cqg.2	-	2	1997	c.1796C>T	c.(1795-1797)CCC>CTC	p.P599L	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.P599L	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	599						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGGCAGCAGGGGGAAGAGGGC	0.652													50	141					0	0	0.003610	0	0
ARSF	416	broad.mit.edu	37	X	3021913	3021913	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:3021913G>A	uc004cre.1	+	9	1434	c.1213G>A	c.(1213-1215)GAT>AAT	p.D405N	ARSF_uc004crf.1_Missense_Mutation_p.D405N	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	405						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAGTTTAATGGATATTTTACC	0.483													21	56					0	0	0.002299	0	0
ARSF	416	broad.mit.edu	37	X	3030423	3030423	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:3030423G>A	uc004cre.1	+	11	1820	c.1599G>A	c.(1597-1599)AAG>AAA	p.K533K	ARSF_uc004crf.1_Silent_p.K533K	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	533						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGATTAAAAAGGTGGCCAACG	0.562													42	84					0	0	0.007835	0	0
STS	412	broad.mit.edu	37	X	7268099	7268099	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:7268099C>T	uc004cry.3	+	10	1794	c.1549C>T	c.(1549-1551)CCA>TCA	p.P517S		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	517	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	CCCACTAACTCCAGCATCCGA	0.507									Ichthyosis				25	55					0	0	0.002780	0	0
CLCN4	1183	broad.mit.edu	37	X	10181826	10181826	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:10181826G>A	uc004csy.3	+	11	2112	c.1682G>A	c.(1681-1683)TGG>TAG	p.W561*	CLCN4_uc011mid.1_Nonsense_Mutation_p.W467*	NM_001830	NP_001821	P51793	CLCN4_HUMAN	chloride channel 4	561	Helical; (By similarity).					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						ACCAGCAAGTGGGTAGCTGAT	0.527													24	71					0	0	0.006320	0	0
PRPS2	5634	broad.mit.edu	37	X	12838868	12838868	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:12838868C>T	uc004cvb.2	+	6	934	c.810C>T	c.(808-810)GTC>GTT	p.V270V	PRPS2_uc004cva.2_Silent_p.V273V|PRPS2_uc010nec.2_Silent_p.V148V	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	270					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						AGGCTGTTGTCGTCACAAACA	0.473													38	38					0	0	0.004878	0	0
MOSPD2	158747	broad.mit.edu	37	X	14915261	14915261	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:14915261G>A	uc004cwi.2	+	5	466	c.378G>A	c.(376-378)AAG>AAA	p.K126K	MOSPD2_uc004cwj.2_Silent_p.K63K	NM_152581	NP_689794	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	126	CRAL-TRIO.					integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)					TGGACAAAAAGAAGCTCATAG	0.363													25	76					0	0	0.007291	0	0
SCML2	10389	broad.mit.edu	37	X	18264864	18264864	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:18264864C>T	uc004cyl.2	-	13	1812	c.1655G>A	c.(1654-1656)GGA>GAA	p.G552E	SCML2_uc004cyk.3_RNA|SCML2_uc010nfd.1_Missense_Mutation_p.G552E|SCML2_uc011miz.1_Missense_Mutation_p.G486E|SCML2_uc010nfc.2_Missense_Mutation_p.G288E	NM_006089	NP_006080	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2	552					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(33;0.183)					CAAATAATTTCCTGAATTTAG	0.418													91	88					0	0	0.003610	0	0
PPEF1	5475	broad.mit.edu	37	X	18836172	18836172	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:18836172A>T	uc004cyq.2	+	16	1891	c.1410A>T	c.(1408-1410)GAA>GAT	p.E470D	PPEF1_uc004cyp.2_Missense_Mutation_p.E442D|PPEF1_uc004cyr.2_Missense_Mutation_p.E408D|PPEF1_uc004cys.2_Missense_Mutation_p.E470D|PPEF1_uc011mja.1_Missense_Mutation_p.E405D|PPEF1_uc011mjb.1_Missense_Mutation_p.E414D	NM_006240	NP_006231	O14829	PPE1_HUMAN	protein phosphatase with EF hand calcium-binding	470					detection of stimulus involved in sensory perception|protein dephosphorylation		calcium ion binding|iron ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity				0	Hepatocellular(33;0.183)					ATACTATGGAAAACAGCGCCA	0.328													53	57					0	0	0.003610	0	0
DMD	1756	broad.mit.edu	37	X	32380965	32380965	+	Silent	SNP	G	A	A	rs145515413	byFrequency	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:32380965G>A	uc004dda.1	-	37	5509	c.5265C>T	c.(5263-5265)CCC>CCT	p.P1755P	DMD_uc004dcw.2_Silent_p.P411P|DMD_uc004dcx.2_Silent_p.P414P|DMD_uc004dcz.2_Silent_p.P1632P|DMD_uc004dcy.1_Silent_p.P1751P|DMD_uc004ddb.1_Silent_p.P1747P|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1755	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTGAGATTTGGGGCTCTACTA	0.468													25	108					0	0	0.007291	0	0
Unknown	0	broad.mit.edu	37	X	51150748	51150748	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:51150748G>A	uc004dpj.2	+	1	982	c.880G>A	c.(880-882)GAT>AAT	p.D294N		NM_203407	NP_981952			hypothetical protein LOC340602																		CCGAGGCCGCGATTCTGCGCC	0.746													16	13					0	0	0.004007	0	0
SSX8	280659	broad.mit.edu	37	X	52655349	52655349	+	RNA	SNP	T	A	A	rs34990448	by1000genomes	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:52655349T>A	uc011moa.1	+	4		c.476T>A			SSX8_uc011mob.1_RNA					Homo sapiens cDNA FLJ56587 complete cds, highly similar to Protein SSX8.												0						TAGGTTTCAATGTCACCCTCC	0.308													4	176					0	0	0.000602	0	0
KDM5C	8242	broad.mit.edu	37	X	53240720	53240720	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:53240720G>A	uc004drz.2	-	10	1893	c.1360C>T	c.(1360-1362)CCT>TCT	p.P454S	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Missense_Mutation_p.P387S|KDM5C_uc004dsa.2_Missense_Mutation_p.P453S	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	454					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						TCACTGACAGGGAAACCGCTG	0.388			N|F|S		clear cell renal carcinoma								16	37					0	0	0.006122	0	0
PHF8	23133	broad.mit.edu	37	X	54014280	54014280	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:54014280C>T	uc004dsu.2	-	15	2009	c.1936G>A	c.(1936-1938)GAA>AAA	p.E646K	PHF8_uc004dst.2_Missense_Mutation_p.E610K|PHF8_uc004dsv.2_Missense_Mutation_p.E476K|PHF8_uc004dsw.2_Missense_Mutation_p.E509K|PHF8_uc004dsx.2_Missense_Mutation_p.E374K|PHF8_uc004dsy.2_Missense_Mutation_p.E610K	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	646					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						AAGTCAAATTCGTCTTCCATC	0.453													26	24					0	0	0.006320	0	0
TSR2	90121	broad.mit.edu	37	X	54470529	54470529	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:54470529G>A	uc004dte.2	+	4	355	c.353G>A	c.(352-354)AGA>AAA	p.R118K	TSR2_uc004dtf.2_Missense_Mutation_p.R23K	NM_058163	NP_477511	Q969E8	TSR2_HUMAN	TSR2, 20S rRNA accumulation, homolog	118					rRNA processing		protein binding				0						ATCACTCAGAGAAAATGCAAG	0.522													31	101					0	0	0.001786	0	0
FAM123B	139285	broad.mit.edu	37	X	63412416	63412416	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:63412416C>T	uc004dvo.2	-	2	1024	c.751G>A	c.(751-753)GAG>AAG	p.E251K		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	251					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GCCATTTTCTCAGTAGCTGGT	0.537													45	172					0	0	0.003610	0	0
MED12	9968	broad.mit.edu	37	X	70352255	70352255	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:70352255G>A	uc004dyy.2	+	31	4481	c.4282G>A	c.(4282-4284)GTG>ATG	p.V1428M	MED12_uc011mpq.1_Missense_Mutation_p.V1428M|MED12_uc004dyz.2_Missense_Mutation_p.V1428M|MED12_uc004dza.2_Missense_Mutation_p.V1275M|MED12_uc010nla.2_Missense_Mutation_p.V54M	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1428					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGTATGGCTGGTGGCCCCCCT	0.562													16	37					0	0	0.008871	0	0
RGAG4	340526	broad.mit.edu	37	X	71350311	71350311	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:71350311C>T	uc010nlh.1	-	1	1441	c.1080G>A	c.(1078-1080)AAG>AAA	p.K360K	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	360										ovary(2)|skin(1)	3	Renal(35;0.156)					TCCTCTGGTCCTTGGAGTGAA	0.353													20	9					0	0	0.007413	0	0
TSIX	9383	broad.mit.edu	37	X	73043464	73043464	+	RNA	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:73043464A>T	uc004ebn.2	+	1		c.31425A>T			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						TTTTATCATCAGCACTTAAGA	0.378													4	155					0	0	0.000248	0	0
TSIX	9383	broad.mit.edu	37	X	73043903	73043903	+	RNA	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:73043903T>A	uc004ebn.2	+	1		c.31864T>A			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						AGGATAAGAGTAATCAATGAT	0.219													5	29					0	0	0.001168	0	0
CYLC1	1538	broad.mit.edu	37	X	83129238	83129238	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:83129238G>A	uc004eei.1	+	4	1543	c.1522G>A	c.(1522-1524)GAT>AAT	p.D508N	CYLC1_uc004eeh.1_Missense_Mutation_p.D507N	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	508	7.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						TTCAAAGAAAGATATCAAGAA	0.353													4	17					0	0	0.000602	0	0
POF1B	79983	broad.mit.edu	37	X	84586003	84586003	+	Missense_Mutation	SNP	G	A	A	rs148186919	by1000genomes	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:84586003G>A	uc004eer.2	-	7	952	c.806C>T	c.(805-807)ACG>ATG	p.T269M	POF1B_uc004ees.2_Missense_Mutation_p.T269M	NM_024921	NP_079197	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	269							actin binding				0						ATATAGATCCGTATTCTTACG	0.383													30	19					0	0	0.008361	0	0
KLHL4	56062	broad.mit.edu	37	X	86873070	86873070	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:86873070G>A	uc004efb.2	+	4	1045	c.863G>A	c.(862-864)CGA>CAA	p.R288Q	KLHL4_uc004efa.2_Missense_Mutation_p.R288Q	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	288						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TTAGGGATTCGATCATTTGGA	0.418													12	44					0	0	0.002450	0	0
KLHL4	56062	broad.mit.edu	37	X	86890621	86890621	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:86890621G>A	uc004efb.2	+	9	1953	c.1771G>A	c.(1771-1773)GAC>AAC	p.D591N	KLHL4_uc004efa.2_Missense_Mutation_p.D591N	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	591	Kelch 4.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GGAATACTTTGACCCACACAC	0.413													13	43					0	0	0.001368	0	0
PCDH19	57526	broad.mit.edu	37	X	99662087	99662087	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:99662087G>A	uc010nmz.2	-	1	3185	c.1509C>T	c.(1507-1509)TTC>TTT	p.F503F	PCDH19_uc004efw.3_Silent_p.F503F|PCDH19_uc004efx.3_Silent_p.F503F	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AGACATAGGTGAAGACAGGCA	0.582													79	67					0	0	0.003610	0	0
SYTL4	94121	broad.mit.edu	37	X	99936232	99936232	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:99936232C>T	uc004egd.3	-	16	1906	c.1550G>A	c.(1549-1551)CGG>CAG	p.R517Q	SYTL4_uc004egc.2_5'Flank|SYTL4_uc010nnb.2_Missense_Mutation_p.R189Q|SYTL4_uc010nnc.2_Missense_Mutation_p.R517Q|SYTL4_uc004ege.3_Missense_Mutation_p.R517Q|SYTL4_uc004egf.3_Missense_Mutation_p.R517Q	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	517	C2 2.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACTCTTTTTCCGGTCACCTCC	0.512													18	42					0	0	0.008871	0	0
CSTF2	1478	broad.mit.edu	37	X	100092352	100092352	+	Missense_Mutation	SNP	A	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:100092352A>T	uc004egh.2	+	12	1583	c.1525A>T	c.(1525-1527)ATG>TTG	p.M509L	CSTF2_uc010nnd.2_Missense_Mutation_p.M529L|CSTF2_uc004egi.2_Missense_Mutation_p.M492L	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	509	Gly/Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						GGGAACAGGAATGCAAGGAGC	0.453													38	27					0	0	0.006999	0	0
CXorf41	139212	broad.mit.edu	37	X	106466000	106466001	+	Missense_Mutation	DNP	GT	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:106466000_106466001GT>AA	uc004enc.2	+	5	420_421	c.358_359GT>AA	c.(358-360)GTG>AAG	p.V120K	CXorf41_uc004end.2_Missense_Mutation_p.V120K	NM_173494	NP_775765	Q9NQM4	CX041_HUMAN	hypothetical protein LOC139212	120											0						CAGACAGCAGGTGGGAACTGAA	0.376													25	108					0	0	0.004672	0	0
COL4A5	1287	broad.mit.edu	37	X	107850081	107850081	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:107850081C>T	uc004enz.1	+	29	2556	c.2354C>T	c.(2353-2355)CCT>CTT	p.P785L	COL4A5_uc011mso.1_Missense_Mutation_p.P785L|COL4A5_uc004eob.1_Missense_Mutation_p.P393L	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	785	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						CCTCCGGGTCCTCCAGGACGC	0.517									Alport_syndrome_with_Diffuse_Leiomyomatosis				32	116					0	0	0.003271	0	0
COL4A5	1287	broad.mit.edu	37	X	107850122	107850123	+	Splice_Site	DNP	GG	AA	AA			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:107850122_107850123GG>AA	uc004enz.1	+	29	2597	c.2395_splice	c.e29+1	p.G799_splice	COL4A5_uc011mso.1_Splice_Site_p.G799_splice|COL4A5_uc004eob.1_Splice_Site_p.G407_splice	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor						axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TGGACCAAAAGGTATGGAGGCT	0.48									Alport_syndrome_with_Diffuse_Leiomyomatosis				57	68					0	0	0.004672	0	0
AMOT	154796	broad.mit.edu	37	X	112048315	112048315	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:112048315C>T	uc004epr.2	-	5	1636	c.1636G>A	c.(1636-1638)GAA>AAA	p.E546K	AMOT_uc004eps.2_Missense_Mutation_p.E137K	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	546	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						CGCTGGCTTTCTTTATCTGTC	0.483													56	138					0	0	0.003610	0	0
KIAA1210	57481	broad.mit.edu	37	X	118227629	118227629	+	Splice_Site	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:118227629C>T	uc004era.3	-	10	1483	c.1483_splice	c.e10+1	p.D495_splice		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481											ovary(4)|skin(1)	5						GATATGCTAACCTGCACTGTC	0.438													18	12					0	0	0.007413	0	0
UPF3B	65109	broad.mit.edu	37	X	118986799	118986799	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:118986799C>T	uc004erz.1	-	1	170	c.93G>A	c.(91-93)GGG>GGA	p.G31G	UPF3B_uc004esa.1_Silent_p.G31G	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	31	Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						TGGAGCTGTCCCCCGAGGTCC	0.637													119	95					0	0	0.003610	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298919	125298919	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:125298919G>A	uc004euk.1	-	1	1016	c.989C>T	c.(988-990)TCC>TTC	p.S330F		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	330										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						ATCCAGGAAGGAGACGTGGGA	0.617													31	95					0	0	0.002096	0	0
SMARCA1	6594	broad.mit.edu	37	X	128602861	128602861	+	Nonsense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:128602861G>A	uc004eun.3	-	21	2700	c.2587C>T	c.(2587-2589)CGA>TGA	p.R863*	SMARCA1_uc004eup.3_Nonsense_Mutation_p.R851*|SMARCA1_uc011muk.1_Nonsense_Mutation_p.R863*|SMARCA1_uc011mul.1_Nonsense_Mutation_p.R851*	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	863	SANT 1.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						TTAAAATCTCGTTTAGTCCAG	0.338													9	51					0	0	0.006214	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130219668	130219668	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:130219668C>T	uc004evz.2	+	8	1407	c.1062C>T	c.(1060-1062)ATC>ATT	p.I354I	ARHGAP36_uc004ewa.2_Silent_p.I342I|ARHGAP36_uc004ewb.2_Silent_p.I323I|ARHGAP36_uc004ewc.2_Silent_p.I218I	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	354	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						TGCATAAAATCACTGAGAACT	0.498													75	222					0	0	0.003610	0	0
FRMD7	90167	broad.mit.edu	37	X	131212337	131212337	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:131212337C>T	uc004ewn.2	-	12	1886	c.1708G>A	c.(1708-1710)GAA>AAA	p.E570K	FRMD7_uc011muy.1_Missense_Mutation_p.E555K	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	570					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TTTGGGTCTTCCTCTTCTAGA	0.418													83	75					0	0	0.003610	0	0
SAGE1	55511	broad.mit.edu	37	X	134992215	134992215	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:134992215G>A	uc004ezh.2	+	15	1917	c.1750G>A	c.(1750-1752)GAA>AAA	p.E584K	SAGE1_uc010nry.1_Missense_Mutation_p.E553K|SAGE1_uc011mvv.1_Missense_Mutation_p.E208K	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	584										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CAATGTCCATGAAGAGAAGAT	0.408													24	78					0	0	0.003954	0	0
GPR112	139378	broad.mit.edu	37	X	135432543	135432543	+	Silent	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:135432543C>T	uc004ezu.1	+	6	6969	c.6678C>T	c.(6676-6678)TCC>TCT	p.S2226S	GPR112_uc010nsb.1_Silent_p.S2021S|GPR112_uc010nsc.1_Silent_p.S1993S	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2226	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CCACACCTTCCTTTCTATCTA	0.463													24	85					0	0	0.003330	0	0
VGLL1	51442	broad.mit.edu	37	X	135631094	135631094	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:135631094G>A	uc004ezy.2	+	3	731	c.561G>A	c.(559-561)AGG>AGA	p.R187R	MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	187					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					CTGCCGCCAGGGAGAATGGCA	0.567													65	70					0	0	0.003610	0	0
MIR509-2	100126301	broad.mit.edu	37	X	146340352	146340352	+	RNA	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:146340352G>A	hsa-mir-509-2|MI0005530	-			c.17G>A																				0						CTGCAGTAGGGTACCACACAC	0.438													26	93					0	0	0.004878	0	0
CSAG1	158511	broad.mit.edu	37	X	151908889	151908889	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:151908889C>T	uc004fge.2	+	4	456	c.128C>T	c.(127-129)TCC>TTC	p.S43F	CSAG1_uc004fgf.2_Missense_Mutation_p.S43F|CSAG1_uc004fgd.2_RNA	NM_153478	NP_705611	Q6PB30	CSAG1_HUMAN	chondrosarcoma associated gene 1 precursor	43										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CCACGAGCCTCCAGCCCATTT	0.547													68	199					0	0	0.003610	0	0
SLC6A8	6535	broad.mit.edu	37	X	152954135	152954135	+	Missense_Mutation	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:152954135G>A	uc004fib.3	+	1	384	c.106G>A	c.(106-108)GGC>AGC	p.G36S	SLC6A8_uc004fic.3_Missense_Mutation_p.G36S|SLC6A8_uc011myx.1_5'Flank|PNCK_uc011myw.1_5'Flank|SLC6A8_uc010nui.1_5'Flank	NM_005629	NP_005620	P48029	SC6A8_HUMAN	solute carrier family 6 member 8 isoform 1	36	Cytoplasmic (Potential).				creatine metabolic process|muscle contraction	integral to plasma membrane	creatine:sodium symporter activity|neurotransmitter:sodium symporter activity			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Creatine(DB00148)	cAAGGGCGACGGCCCCGTGGG	0.597													6	6					0	0	0.001168	0	0
PDZD4	57595	broad.mit.edu	37	X	153068892	153068892	+	Silent	SNP	G	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:153068892G>A	uc004fiz.1	-	8	2476	c.2226C>T	c.(2224-2226)ACC>ACT	p.T742T	PDZD4_uc004fiy.1_Silent_p.T667T|PDZD4_uc004fix.2_Silent_p.T646T|PDZD4_uc004fja.1_Silent_p.T748T|PDZD4_uc011mze.1_Silent_p.T633T	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	742						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCTGGATGGTGATCCAGT	0.602													24	23					0	0	0.002780	0	0
HCFC1	3054	broad.mit.edu	37	X	153218265	153218265	+	Missense_Mutation	SNP	C	T	T			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:153218265C>T	uc004fjp.2	-	19	5170	c.4642G>A	c.(4642-4644)GAT>AAT	p.D1548N		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1548					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTGCTCAGATCCACGGCGGCC	0.697											OREG0003630	type=REGULATORY REGION|Gene=BC010606|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	11					0	0	0.006214	0	0
EMD	2010	broad.mit.edu	37	X	153609333	153609333	+	Missense_Mutation	SNP	T	A	A			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chrX:153609333T>A	uc004fkl.2	+	6	789	c.541T>A	c.(541-543)TAT>AAT	p.Y181N		NM_000117	NP_000108	P50402	EMD_HUMAN	emerin	181	Interaction with F-actin (Probable).|Interaction with CTNNB1.				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGACCTGTCCTATTATCCTAC	0.587													41	45					0	0	0.006230	0	0
HAX1	10456	broad.mit.edu	37	1	154245864	154245866	+	In_Frame_Del	DEL	GAA	-	-	rs11556342		TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr1:154245864_154245866delGAA	uc001fes.2	+	2	267_269	c.106_108delGAA	c.(106-108)GAAdel	p.E40del	HAX1_uc001fet.2_Intron|HAX1_uc010peo.1_In_Frame_Del_p.E40del|HAX1_uc009wou.2_5'UTR|HAX1_uc009wov.2_In_Frame_Del_p.E14del	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	40	Asp/Glu-rich (highly acidic).|Required for localization in mitochondria (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGATGATGAGGAAGAAGAAGAAG	0.522									Kostmann_syndrome				7	99	---	---	---	---					
CCDC81	60494	broad.mit.edu	37	11	86131005	86131014	+	Frame_Shift_Del	DEL	TAAATAGAGT	-	-	rs143827396	byFrequency	TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr11:86131005_86131014delTAAATAGAGT	uc001pbx.1	+	14	2155_2164	c.1727_1736delTAAATAGAGT	c.(1726-1737)GTAAATAGAGTCfs	p.V576fs	CCDC81_uc001pbw.1_Frame_Shift_Del_p.V486fs|CCDC81_uc010rtq.1_Frame_Shift_Del_p.V359fs|CCDC81_uc001pby.1_Frame_Shift_Del_p.V311fs	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	576_579										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CTGGAGCGAGTAAATAGAGTCAACCAATGC	0.514													30	24	---	---	---	---					
KIAA0182	23199	broad.mit.edu	37	16	85682289	85682290	+	Frame_Shift_Ins	INS	-	C	C			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr16:85682289_85682290insC	uc002fix.2	+	3	432_433	c.358_359insC	c.(358-360)ACCfs	p.T120fs	KIAA0182_uc002fiw.2_Frame_Shift_Ins_p.T16fs|KIAA0182_uc002fiy.2_Frame_Shift_Ins_p.T47fs	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	120							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						CGTGCCCAGCACCCCCCCCGTG	0.688													7	172	---	---	---	---					
GSDMC	56169	broad.mit.edu	37	8	130789808	130789808	+	Frame_Shift_Del	DEL	C	-	-			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr8:130789808delC	uc003ysr.2	-	2	908	c.26delG	c.(25-27)AGCfs	p.S9fs		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	9						mitochondrion				ovary(2)|skin(1)	3						CAAATTTTTGCTAATGCGTTC	0.403													33	76	---	---	---	---					
C9orf43	257169	broad.mit.edu	37	9	116187646	116187648	+	In_Frame_Del	DEL	GCA	-	-			TCGA-ER-A19D-06A-11D-A197-08	TCGA-ER-A19D-10A-01D-A199-08									Somatic	Phase_I	Capture				Illumina GAIIx	c21a5d55-9790-429f-a4e6-420293c07b53	36e999ee-96c4-47cc-865c-4eb8c9306c57	g.chr9:116187646_116187648delGCA	uc004bho.3	+	10	1284_1286	c.888_890delGCA	c.(886-891)CGGCAG>CGG	p.Q304del	C9orf43_uc004bhp.2_In_Frame_Del_p.Q304del	NM_152786	NP_689999	Q8TAL5	CI043_HUMAN	hypothetical protein LOC257169	304	Gln-rich.										0						agcagcagcggcagcagcagcag	0.438													7	122	---	---	---	---					
