Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
MXRA8	54587	broad.mit.edu	37	1	1290355	1290355	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:1290355G>A	uc001aew.2	-	5	687	c.656C>T	c.(655-657)GCG>GTG	p.A219V	MXRA8_uc001aex.3_Missense_Mutation_p.A219V|MXRA8_uc001aey.3_Missense_Mutation_p.A219V|MXRA8_uc010nyl.1_Missense_Mutation_p.A219V|MXRA8_uc001aez.2_Missense_Mutation_p.A118V|MXRA8_uc001afa.2_Missense_Mutation_p.A210V	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	219	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CAGGCGGTCCGCGCGGTCGTG	0.736000													4	7					0	0	1	0	0	
CCNL2	81669	broad.mit.edu	37	1	1322694	1322694	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:1322694G>A	uc001afi.2	-	11	1512	c.1480C>T	c.(1480-1482)CGA>TGA	p.R494*	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Nonsense_Mutation_p.R272*|CCNL2_uc001afg.1_Nonsense_Mutation_p.R272*|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	494					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CGCTCTCGTCGCTGATCTCTG	0.592000													49	69					0	0	1	0	0	
NADK	65220	broad.mit.edu	37	1	1685501	1685501	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:1685501C>T	uc009vkw.2	-	10	1211	c.1090G>A	c.(1090-1092)GTC>ATC	p.V364I	NADK_uc001aic.2_Missense_Mutation_p.V364I|NADK_uc001aid.3_Missense_Mutation_p.V364I|NADK_uc001aie.2_Missense_Mutation_p.V509I|NADK_uc010nyv.1_Missense_Mutation_p.V332I	NM_023018	NP_075394	O95544	NADK_HUMAN	NAD kinase	364					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		TTCAGCTCGACCCCTGCGGGG	0.637000													40	74					0	0	1	0	0	
MMEL1	79258	broad.mit.edu	37	1	2526797	2526797	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:2526797G>A	uc001ajy.2	-	16	1716	c.1502C>T	c.(1501-1503)GCC>GTC	p.A501V	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	501	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GATGCTCATGGCCTGAGTGGG	0.662000													22	31					0	0	1	0	0	
MEGF6	1953	broad.mit.edu	37	1	3410411	3410411	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:3410411G>A	uc001akl.2	-	34	4538	c.4311C>T	c.(4309-4311)GAC>GAT	p.D1437D	MEGF6_uc001akk.2_Intron	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	1437						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GTGCCCCCCCGTCACAGTCAC	0.662000													3	5					0	0	1	0	0	
AJAP1	55966	broad.mit.edu	37	1	4829964	4829964	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:4829964T>C	uc001alm.1	+	3	1262	c.881T>C	c.(880-882)ATA>ACA	p.I294T	AJAP1_uc001aln.2_Missense_Mutation_p.I294T	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	294	Helical; Signal-anchor for type III membrane protein; (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		ATCATGGTCATAGCTGCTCTC	0.532000													63	114					0	0	1	0	0	
CHD5	26038	broad.mit.edu	37	1	6209392	6209392	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:6209392C>T	uc001amb.1	-	8	1175	c.1075G>A	c.(1075-1077)GAC>AAC	p.D359N	CHD5_uc001amc.1_5'Flank	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	359	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGGCAGGTGTCGCACAGGATG	0.607000													16	36					0	0	1	0	0	
TNFRSF25	8718	broad.mit.edu	37	1	6521693	6521693	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:6521693C>T	uc001ane.2	-	10	1143	c.1055G>A	c.(1054-1056)CGC>CAC	p.R352H	TNFRSF25_uc001ana.2_Missense_Mutation_p.R169H|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Missense_Mutation_p.R125H|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Missense_Mutation_p.R315H|TNFRSF25_uc001ang.2_Missense_Mutation_p.R307H|TNFRSF25_uc001anh.2_Missense_Mutation_p.R361H	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	352	Death.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CCCCAGCGTGCGCACGAACTC	0.692000													11	17					0	0	1	0	0	
TNFRSF25	8718	broad.mit.edu	37	1	6525249	6525249	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:6525249C>T	uc001ane.2	-	3	282	c.194G>A	c.(193-195)TGC>TAC	p.C65Y	TNFRSF25_uc001ana.2_Intron|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Intron|TNFRSF25_uc009vlz.2_Intron|TNFRSF25_uc001anf.2_Missense_Mutation_p.C65Y|TNFRSF25_uc001ang.2_Intron|TNFRSF25_uc001anh.2_Missense_Mutation_p.C65Y|TNFRSF25_uc001ani.1_Missense_Mutation_p.C65Y	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	65	TNFR-Cys 1.|Extracellular (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		GGAGTTGCCGCAGGGCTCCGT	0.592000													13	17					0	0	1	0	0	
KLHL21	9903	broad.mit.edu	37	1	6659214	6659214	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:6659214G>A	uc001aoa.2	-	2	1372	c.1320C>T	c.(1318-1320)TGC>TGT	p.C440C	KLHL21_uc001anz.1_Silent_p.C440C|KLHL21_uc009vme.2_Silent_p.C73C	NM_014851	NP_055666	Q9UJP4	KLH21_HUMAN	kelch-like 21	440	Kelch 4.				anaphase|cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|cytoplasm|polar microtubule				central_nervous_system(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;7.39e-28)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.4e-05)|Kidney(185;4.95e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000528)|KIRC - Kidney renal clear cell carcinoma(229;0.000927)|STAD - Stomach adenocarcinoma(132;0.0172)|READ - Rectum adenocarcinoma(331;0.0644)		CCGGGTCGTAGCACTGCATCA	0.637000													15	28					0	0	1	0	0	
PER3	8863	broad.mit.edu	37	1	7887206	7887206	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:7887206G>A	uc001aoo.2	+	17	2368	c.2193G>A	c.(2191-2193)TCG>TCA	p.S731S	PER3_uc009vmg.1_Silent_p.S739S|PER3_uc009vmh.1_Silent_p.S732S|PER3_uc001aop.2_Silent_p.S739S|PER3_uc010nzw.1_Silent_p.S420S	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	731	CSNK1E binding domain (By similarity).|Nuclear localization signal (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity	p.G733fs*115(1)		ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		AGACGCGGTCGGCCGGCTGCA	0.557000													20	14					0	0	1	0	0	
SLC45A1	50651	broad.mit.edu	37	1	8390709	8390709	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:8390709G>A	uc001apb.2	+	4	1156	c.1156G>A	c.(1156-1158)GAC>AAC	p.D386N	SLC45A1_uc001apc.2_Missense_Mutation_p.D84N	NM_001080397	NP_001073866	Q9Y2W3	S45A1_HUMAN	DNB5	386					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GGGCGGCCACGACAGCTACCT	0.662000													16	30					0	0	1	0	0	
SLC2A7	155184	broad.mit.edu	37	1	9075181	9075181	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:9075181C>T	uc009vmo.1	-	6	710	c.710G>A	c.(709-711)CGA>CAA	p.R237Q		NM_207420	NP_997303	Q6PXP3	GTR7_HUMAN	intestinal facilitative glucose transporter 7	237	Cytoplasmic (Potential).					integral to membrane|plasma membrane	sugar transmembrane transporter activity				0	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CATACCTTGTCGCGCTGTGGC	0.662000													10	11					0	0	1	0	0	
CASZ1	54897	broad.mit.edu	37	1	10700033	10700033	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:10700033G>A	uc001aro.2	-	21	4566	c.4246C>T	c.(4246-4248)CGG>TGG	p.R1416W		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GCCGTCTTCCGCCGCTTGCCG	0.627000													21	25					0	0	1	0	0	
MTOR	2475	broad.mit.edu	37	1	11303337	11303337	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:11303337T>C	uc001asd.2	-	9	1367	c.1246A>G	c.(1246-1248)ACC>GCC	p.T416A		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	416					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TGGTTCATGGTATCTTGGAGA	0.473000													45	57					0	0	1	0	0	
C1orf187	374946	broad.mit.edu	37	1	11766419	11766419	+	Missense_Mutation	SNP	G	A	A	rs149999195		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:11766419G>A	uc001asr.1	+	2	244	c.104G>A	c.(103-105)CGG>CAG	p.R35Q		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	35					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		ACCCCTGCCCGGAACCTCCCT	0.706000													18	32					0	0	1	0	0	
CLCN6	1185	broad.mit.edu	37	1	11900199	11900199	+	Splice_Site	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:11900199G>C	uc001ate.3	+	23	2643	c.2530_splice	c.e23-1	p.I844_splice	CLCN6_uc010oat.1_Splice_Site_p.I560_splice|CLCN6_uc010oau.1_Splice_Site_p.I822_splice|CLCN6_uc010oav.1_5'Flank|CLCN6_uc010oaw.1_5'Flank|CLCN6_uc010oax.1_5'Flank|CLCN6_uc010oay.1_5'Flank|CLCN6_uc010oaz.1_5'Flank|CLCN6_uc010oba.1_5'Flank	NM_001286	NP_001277	P51797	CLCN6_HUMAN	chloride channel 6 isoform ClC-6a						cell volume homeostasis|signal transduction	endosome membrane|integral to membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000816)|KIRC - Kidney renal clear cell carcinoma(229;0.00268)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CTTTGCCCTAGATCGTGGGGA	0.572000													42	65					0	0	1	0	0	
VPS13D	55187	broad.mit.edu	37	1	12359286	12359286	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:12359286C>T	uc001atv.2	+	25	6202	c.6061C>T	c.(6061-6063)CGG>TGG	p.R2021W	VPS13D_uc001atw.2_Missense_Mutation_p.R2021W|VPS13D_uc001atx.2_Missense_Mutation_p.R1209W	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2021					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GCGCTGTTCACGGGTTCTCCT	0.438000													30	57					0	0	1	0	0	
VPS13D	55187	broad.mit.edu	37	1	12401935	12401935	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:12401935C>T	uc001atv.2	+	41	8866	c.8725C>T	c.(8725-8727)CCC>TCC	p.P2909S	VPS13D_uc001atw.2_Missense_Mutation_p.P2884S|VPS13D_uc001atx.2_Missense_Mutation_p.P2096S	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2908					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GACCACCACACCCACCAGGTA	0.577000													32	64					0	0	1	0	0	
PRDM2	7799	broad.mit.edu	37	1	14075941	14075941	+	Missense_Mutation	SNP	C	T	T	rs144833671	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:14075941C>T	uc001avi.2	+	6	1326	c.470C>T	c.(469-471)GCC>GTC	p.A157V	PRDM2_uc001avg.2_Missense_Mutation_p.A157V|PRDM2_uc001avh.2_Missense_Mutation_p.A157V|PRDM2_uc001avj.2_RNA|PRDM2_uc009vod.1_5'UTR|PRDM2_uc001avk.2_5'UTR|PRDM2_uc009voe.2_RNA|PRDM2_uc009vof.2_RNA	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	157						Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GAAGAGCGAGCCAGCGCCCGG	0.468000													7	19					0	0	1	0	0	
EFHD2	79180	broad.mit.edu	37	1	15755104	15755104	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:15755104G>A	uc001awh.2	+	4	684	c.607G>A	c.(607-609)GTG>ATG	p.V203M		NM_024329	NP_077305	Q96C19	EFHD2_HUMAN	EF-hand domain family, member D2	203						membrane raft					0		Renal(390;0.00145)|Breast(348;0.00173)|Colorectal(325;0.00215)|all_lung(284;0.00366)|Lung NSC(340;0.00395)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)|Hepatocellular(190;0.152)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.59e-07)|COAD - Colon adenocarcinoma(227;3.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000119)|KIRC - Kidney renal clear cell carcinoma(229;0.00251)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCATCAACGTGTCCAGCCG	0.572000													3	19					0	0	1	0	0	
PLEKHM2	23207	broad.mit.edu	37	1	16011067	16011067	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:16011067A>G	uc010obo.1	+	1	241	c.14A>G	c.(13-15)GAG>GGG	p.E5G		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	5	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GAGCCGGGGGAGGTGAAGGAC	0.338000													5	11					0	0	1	0	0	
PLEKHM2	23207	broad.mit.edu	37	1	16052022	16052022	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:16052022C>T	uc010obo.1	+	8	1150	c.923C>T	c.(922-924)ACG>ATG	p.T308M		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	308	Interaction with KIF5B.				Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GATGCCTGCACGGAGCTCGAG	0.657000													4	4					0	0	1	0	0	
PLEKHM2	23207	broad.mit.edu	37	1	16053733	16053733	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:16053733C>T	uc010obo.1	+	9	1393	c.1166C>T	c.(1165-1167)TCC>TTC	p.S389F		NM_015164	NP_055979	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M	389					Golgi organization	cytoplasm	kinesin binding			ovary(1)	1		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		AGCGAGCGCTCCGAGCCGGGC	0.672000													10	9					0	0	1	0	0	
FAM131C	348487	broad.mit.edu	37	1	16389001	16389001	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:16389001G>T	uc001axz.3	-	3	357	c.167C>A	c.(166-168)CCT>CAT	p.P56H	FAM131C_uc010obz.1_Missense_Mutation_p.P56H	NM_182623	NP_872429	Q96AQ9	F131C_HUMAN	hypothetical protein LOC348487	56											0		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;8.32e-08)|COAD - Colon adenocarcinoma(227;5.56e-06)|BRCA - Breast invasive adenocarcinoma(304;9.12e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.00656)|READ - Rectum adenocarcinoma(331;0.0649)		GACCTGCCAAGGATCCCAACA	0.602000													3	4					0.115264	0.115772	1	1	0	
FBXO42	54455	broad.mit.edu	37	1	16583174	16583174	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:16583174G>A	uc001ayg.2	-	5	799	c.583C>T	c.(583-585)CCA>TCA	p.P195S	FBXO42_uc001aye.3_5'Flank|FBXO42_uc001ayf.2_Missense_Mutation_p.P102S	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	195	Kelch 2.									upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		TAAGGGCTTGGCCGCGTCCAG	0.468000													20	38					0	0	1	0	0	
NBPF1	55672	broad.mit.edu	37	1	16914226	16914226	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:16914226G>A	uc009vos.1	-	10	1448	c.560C>T	c.(559-561)GCC>GTC	p.A187V	NBPF1_uc009vot.1_5'Flank|NBPF1_uc001ayz.1_5'Flank|NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	187	NBPF 1.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TTACCTGGGGGCAGATGATTC	0.438000													84	362					0	0	1	0	0	
CROCC	9696	broad.mit.edu	37	1	17256811	17256811	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:17256811G>A	uc001azt.2	+	6	721	c.652G>A	c.(652-654)GCC>ACC	p.A218T	CROCC_uc009voy.1_5'UTR|CROCC_uc009voz.1_5'UTR	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	218	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CCTGGAAAGCGCCCTCATCCG	0.677000													7	21					0	0	1	0	0	
PAX7	5081	broad.mit.edu	37	1	19062247	19062247	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:19062247G>A	uc001bay.2	+	8	1875	c.1277G>A	c.(1276-1278)CGG>CAG	p.R426Q	PAX7_uc001baz.2_Missense_Mutation_p.R424Q|PAX7_uc010oct.1_Missense_Mutation_p.R426Q	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	426					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		TGCAGCCAGCGGGCCGACTCC	0.701000			T	FOXO1A	alveolar rhabdomyosarcoma								47	65					0	0	1	0	0	
HP1BP3	50809	broad.mit.edu	37	1	21076290	21076290	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:21076290G>A	uc001bdw.1	-	10	1207	c.1067C>T	c.(1066-1068)CCG>CTG	p.P356L	HP1BP3_uc001bdv.1_Missense_Mutation_p.P318L|HP1BP3_uc010odh.1_Missense_Mutation_p.P318L|HP1BP3_uc001bdy.1_Missense_Mutation_p.P356L|HP1BP3_uc010odf.1_Missense_Mutation_p.P15L|HP1BP3_uc010odg.1_Missense_Mutation_p.P204L	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	356	H15 3.				nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		GCAGGTCTTCGGCTCATTCAT	0.453000													41	79					0	0	1	0	0	
EIF4G3	8672	broad.mit.edu	37	1	21191619	21191619	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:21191619G>A	uc001bec.2	-	16	2847	c.2591C>T	c.(2590-2592)GCT>GTT	p.A864V	EIF4G3_uc010odi.1_Missense_Mutation_p.A468V|EIF4G3_uc010odj.1_Missense_Mutation_p.A863V|EIF4G3_uc009vpz.2_Missense_Mutation_p.A584V|EIF4G3_uc001bed.2_Missense_Mutation_p.A864V|EIF4G3_uc001bef.2_Missense_Mutation_p.A900V|EIF4G3_uc001bee.2_Missense_Mutation_p.A870V	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	864	eIF3/EIF4A-binding (By similarity).|MIF4G.|HEAT 3.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		AGCACTGGCAGCCTCAAGTTC	0.413000													48	69					0	0	1	0	0	
RAP1GAP	5909	broad.mit.edu	37	1	21929366	21929366	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:21929366G>A	uc001bex.2	-	19	1727	c.1469C>T	c.(1468-1470)TCG>TTG	p.S490L	RAP1GAP_uc001bev.2_Missense_Mutation_p.S575L|RAP1GAP_uc001bew.2_Missense_Mutation_p.S554L|RAP1GAP_uc001bey.2_Missense_Mutation_p.S516L	NM_002885	NP_002876	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein isoform c	490					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|ovary(1)	3		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		GAACGGGCCCGACTTCTTCCT	0.652000													19	25					0	0	1	0	0	
EPHA8	2046	broad.mit.edu	37	1	22925427	22925427	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:22925427C>T	uc001bfx.1	+	13	2400	c.2275C>T	c.(2275-2277)CGA>TGA	p.R759*		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	759	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CTATGTCCACCGAGACCTGGC	0.642000													11	25					0	0	1	0	0	
ASAP3	55616	broad.mit.edu	37	1	23782638	23782638	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:23782638C>T	uc001bha.2	-	2	303	c.179G>A	c.(178-180)CGG>CAG	p.R60Q	ASAP3_uc010odz.1_5'UTR|ASAP3_uc010oea.1_Missense_Mutation_p.R60Q|ASAP3_uc001bhc.1_Missense_Mutation_p.R60Q	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	60					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						ATGGATTGCCCGCACAGCCTT	0.582000													24	24					0	0	1	0	0	
IL28RA	163702	broad.mit.edu	37	1	24485550	24485550	+	Missense_Mutation	SNP	G	A	A	rs146955345		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:24485550G>A	uc001bis.2	-	6	806	c.793C>T	c.(793-795)CGG>TGG	p.R265W	IL28RA_uc001bir.2_Missense_Mutation_p.R265W|IL28RA_uc001bit.2_Intron|IL28RA_uc001biu.2_Missense_Mutation_p.R181W	NM_170743	NP_734464	Q8IU57	I28RA_HUMAN	interleukin 28 receptor, alpha isoform 1	265	Cytoplasmic (Potential).				cytokine-mediated signaling pathway|negative regulation of cell proliferation|regulation of defense response to virus by host	interleukin-28 receptor complex	protein binding|receptor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00117)|all_lung(284;0.00151)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.21e-24)|Colorectal(126;6.61e-08)|COAD - Colon adenocarcinoma(152;3.56e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00918)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.185)		ACCAGGGCCCGTGGCATCTTT	0.552000													37	62					0	0	1	0	0	
AIM1L	55057	broad.mit.edu	37	1	26648679	26648679	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:26648679C>T	uc001bmd.3	-	18	2168	c.1738G>A	c.(1738-1740)GAA>AAA	p.E580K		NM_001039775	NP_001034864	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	580	Ricin B-type lectin.						sugar binding			pancreas(1)	1		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		ATCTGGCCTTCGAACATCTGG	0.622000													100	127					0	0	1	0	0	
ZNF683	257101	broad.mit.edu	37	1	26691260	26691260	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:26691260G>A	uc001bmg.1	-	4	895	c.777C>T	c.(775-777)GCC>GCT	p.A259A	ZNF683_uc001bmh.1_Silent_p.A259A|ZNF683_uc009vsj.1_Silent_p.A259A	NM_173574	NP_775845	Q8IZ20	ZN683_HUMAN	zinc finger protein 683	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		AGGCTTGGAAGGCCCCTGGGT	0.652000													13	25					0	0	1	0	0	
ARID1A	8289	broad.mit.edu	37	1	27058097	27058097	+	Splice_Site	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:27058097T>C	uc001bmv.1	+	3	2176	c.1803_splice	c.e3+2	p.Q601_splice	ARID1A_uc001bmt.1_Splice_Site_p.Q601_splice|ARID1A_uc001bmu.1_Splice_Site_p.Q601_splice|ARID1A_uc001bmw.1_Splice_Site_p.Q218_splice	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a						androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCACCGCAGGTAAGATATCCC	0.577000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								44	62					0	0	1	0	0	
SLC9A1	6548	broad.mit.edu	37	1	27428997	27428997	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:27428997G>A	uc001bnm.2	-	8	2325	c.1699C>T	c.(1699-1701)CGC>TGC	p.R567C	SLC9A1_uc001bnl.2_Missense_Mutation_p.R71C|SLC9A1_uc010ofk.1_Missense_Mutation_p.R228C	NM_003047	NP_003038	P19634	SL9A1_HUMAN	solute carrier family 9, isoform A1	567	Cytoplasmic (Potential).				regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	TCCTTGGAGCGCTCGCCAGCT	0.582000											OREG0013277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	64	82					0	0	1	0	0	
RCC1	1104	broad.mit.edu	37	1	28864477	28864477	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:28864477C>T	uc001bqg.1	+	10	1309	c.1224C>T	c.(1222-1224)GGC>GGT	p.G408G	SNHG3-RCC1_uc001bqa.1_Silent_p.G408G|SNHG3-RCC1_uc001bqb.1_Silent_p.G408G|SNHG3-RCC1_uc001bqc.1_Silent_p.G408G|RCC1_uc001bqe.1_Silent_p.G425G|RCC1_uc001bqf.1_Silent_p.G439G	NM_001269	NP_001260	P18754	RCC1_HUMAN	regulator of chromosome condensation 1 isoform	408	RCC1 7.				cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCGGGGGCCAGCATACAG	0.567000													11	15					0	0	1	0	0	
PTPRU	10076	broad.mit.edu	37	1	29586063	29586063	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:29586063G>A	uc001bru.2	+	5	772	c.662G>A	c.(661-663)CGC>CAC	p.R221H	PTPRU_uc001brv.2_Missense_Mutation_p.R221H|PTPRU_uc001brw.2_Missense_Mutation_p.R221H|PTPRU_uc009vtq.2_Missense_Mutation_p.R221H|PTPRU_uc009vtr.2_Missense_Mutation_p.R221H	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	221	Extracellular (Potential).|Ig-like C2-type.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GAGGCCGAACGCTTCCTCTTG	0.687000													15	22					0	0	1	0	0	
PTPRU	10076	broad.mit.edu	37	1	29644433	29644433	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:29644433C>T	uc001bru.2	+	26	3827	c.3717C>T	c.(3715-3717)GAC>GAT	p.D1239D	PTPRU_uc001brv.2_Silent_p.D1235D|PTPRU_uc001brw.2_Silent_p.D1229D|PTPRU_uc009vtq.2_Silent_p.D1235D|PTPRU_uc009vtr.2_Silent_p.D1226D|PTPRU_uc001brx.2_5'Flank	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1239	Tyrosine-protein phosphatase 2.|Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CCCTGACTGACGTGAGAGCTT	0.622000													11	22					0	0	1	0	0	
KPNA6	23633	broad.mit.edu	37	1	32628102	32628102	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:32628102C>T	uc001bug.2	+	9	976	c.888C>T	c.(886-888)TGC>TGT	p.C296C	KPNA6_uc001buh.2_Silent_p.C71C|KPNA6_uc010ogx.1_Silent_p.C293C|KPNA6_uc010ogy.1_Silent_p.C301C|KPNA6_uc009vtz.2_Silent_p.C191C	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	296	ARM 6.				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CCGGAGTCTGCCGGAGATTGG	0.418000													34	49					0	0	1	0	0	
TXLNA	200081	broad.mit.edu	37	1	32655736	32655736	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:32655736C>T	uc001bui.2	+	6	914	c.849C>T	c.(847-849)GAC>GAT	p.D283D	TXLNA_uc001buj.2_Silent_p.D283D	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin	283	Potential.				cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CACTGAATGACATTCAGCTGC	0.567000													5	6					0	0	1	0	0	
TXLNA	200081	broad.mit.edu	37	1	32658000	32658000	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:32658000C>T	uc001bui.2	+	7	1117	c.1052C>T	c.(1051-1053)GCA>GTA	p.A351V	TXLNA_uc001buj.2_Missense_Mutation_p.A351V	NM_175852	NP_787048	P40222	TXLNA_HUMAN	taxilin	351	Potential.				cell proliferation|exocytosis	cytoplasm|extracellular region	cytokine activity|high molecular weight B cell growth factor receptor binding			ovary(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTAAAGGAGGCAGAAGAGCGG	0.577000													23	29					0	0	1	0	0	
TSSK3	81629	broad.mit.edu	37	1	32829406	32829406	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:32829406T>C	uc001bvf.2	+	2	797	c.356T>C	c.(355-357)GTT>GCT	p.V119A	uc001bve.1_5'Flank	NM_052841	NP_443073	Q96PN8	TSSK3_HUMAN	testis-specific serine kinase 3	119	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.17)|Breast(348;0.212)				CGTCAGATGGTTGAGGCCATC	0.597000													38	57					0	0	1	0	0	
KIAA1522	57648	broad.mit.edu	37	1	33236614	33236614	+	Nonsense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:33236614A>T	uc001bvv.2	+	6	1793	c.1657A>T	c.(1657-1659)AAA>TAA	p.K553*	KIAA1522_uc001bvu.1_Nonsense_Mutation_p.K612*|KIAA1522_uc010ohm.1_Nonsense_Mutation_p.K564*|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	553	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCAGCCCCCTAAACCAGAGCG	0.642000													38	45					0	0	1	0	0	
TFAP2E	339488	broad.mit.edu	37	1	36053953	36053953	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:36053953C>T	uc010ohy.1	+	4	793	c.585C>T	c.(583-585)AGC>AGT	p.S195S	PSMB2_uc001bzd.1_Intron	NM_178548	NP_848643	Q6VUC0	AP2E_HUMAN	transcription factor AP-2 epsilon (activating	195						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				CCAAAGCCAGCAGCCTCTCAG	0.488000													5	65					0	0	1	0	0	
EIF2C1	26523	broad.mit.edu	37	1	36384666	36384666	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:36384666G>A	uc001bzl.2	+	18	2489	c.2276G>A	c.(2275-2277)CGA>CAA	p.R759Q	EIF2C1_uc001bzk.2_Missense_Mutation_p.R684Q|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	759	Piwi.				negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGCACCAGCCGACCATCCCAT	0.522000													15	19					0	0	1	0	0	
MAP7D1	55700	broad.mit.edu	37	1	36636750	36636750	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:36636750C>T	uc001bzz.2	+	2	441	c.225C>T	c.(223-225)GTC>GTT	p.V75V	MAP7D1_uc001caa.2_Silent_p.V75V|MAP7D1_uc001cab.2_Silent_p.V75V|MAP7D1_uc001cac.2_5'Flank	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	75	Pro-rich.					cytoplasm|spindle				ovary(3)|breast(2)	5		Myeloproliferative disorder(586;0.0393)				CAGGGCAGGTCGGGCCTAGGC	0.662000													29	37					0	0	1	0	0	
C1orf113	79729	broad.mit.edu	37	1	36785787	36785787	+	Missense_Mutation	SNP	C	T	T	rs150094016	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:36785787C>T	uc010oia.1	+	14	1551	c.1523C>T	c.(1522-1524)TCG>TTG	p.S508L	C1orf113_uc010oib.1_Missense_Mutation_p.S397L|C1orf113_uc010oic.1_RNA|C1orf113_uc009vuz.1_Missense_Mutation_p.S154L	NM_001162530	NP_001156002	A4FU49	SH321_HUMAN	SH3 domain-containing protein C1orf113 isoform	392											0		Myeloproliferative disorder(586;0.0393)				CACTTCTCTTCGGAGGAAGCC	0.557000													28	35					0	0	1	0	0	
MRPS15	64960	broad.mit.edu	37	1	36921447	36921447	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:36921447C>T	uc001cas.2	-	8	880	c.716G>A	c.(715-717)CGG>CAG	p.R239Q		NM_031280	NP_112570	P82914	RT15_HUMAN	mitochondrial ribosomal protein S15 precursor	239					translation	mitochondrial small ribosomal subunit|nuclear membrane	structural constituent of ribosome			ovary(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGGTTCCTCCGCTTTGCTTG	0.463000													56	70					0	0	1	0	0	
CSF3R	1441	broad.mit.edu	37	1	36934824	36934824	+	Silent	SNP	G	A	A	rs142503546		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:36934824G>A	uc001caw.1	-	12	1687	c.1509C>T	c.(1507-1509)ATC>ATT	p.I503I	CSF3R_uc001cat.1_Silent_p.I66I|CSF3R_uc009vvc.1_Intron|CSF3R_uc001cau.1_5'UTR|CSF3R_uc001cav.1_Silent_p.I503I|CSF3R_uc001cax.1_Silent_p.I503I|CSF3R_uc001cay.1_Silent_p.I503I	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	503	Extracellular (Potential).|Fibronectin type-III 4.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	AGGGAGTCACGATGATCTCAT	0.498000													21	25					0	0	1	0	0	
EPHA10	284656	broad.mit.edu	37	1	38227453	38227453	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:38227453G>A	uc009vvi.2	-	3	560	c.474C>T	c.(472-474)GAC>GAT	p.D158D	EPHA10_uc001cbw.3_Silent_p.D158D	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	158	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGAAGCTCTCGTCCGCCGCGA	0.667000													28	37					0	0	1	0	0	
MTF1	4520	broad.mit.edu	37	1	38288281	38288281	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:38288281G>T	uc001cce.1	-	9	1420	c.1279C>A	c.(1279-1281)CTC>ATC	p.L427I	MTF1_uc009vvj.1_Missense_Mutation_p.L118I	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	427	Pro-rich.					nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GGCTCGGAGAGGCCAGGTTGC	0.547000													26	36					2.79863e-10	2.91803e-10	1	1	0	
POU3F1	5453	broad.mit.edu	37	1	38512179	38512179	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:38512179G>T	uc001ccp.1	-	1	272	c.237C>A	c.(235-237)GGC>GGA	p.G79G		NM_002699	NP_002690	Q03052	PO3F1_HUMAN	POU domain, class 3, transcription factor 1	79	Gly-rich.				positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CGCCGCCGCCGCCTCCTCCCG	0.567000													4	3					0.150653	0.151095	1	1	0	
PPT1	5538	broad.mit.edu	37	1	40546109	40546109	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:40546109C>T	uc001cfb.2	-	6	819	c.587G>A	c.(586-588)CGC>CAC	p.R196H	PPT1_uc010ojf.1_Missense_Mutation_p.R146H|PPT1_uc010ojg.1_Missense_Mutation_p.R93H|PPT1_uc009vwa.2_RNA	NM_000310	NP_000301	P50897	PPT1_HUMAN	palmitoyl-protein thioesterase 1 isoform 1	196					brain development|cofactor metabolic process|cofactor transport|DNA fragmentation involved in apoptotic nuclear change|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	axon|cytosol|Golgi apparatus|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity			ovary(1)	1	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCTGTGGTTGCGATACACATC	0.468000													89	151					0	0	1	0	0	
HIVEP3	59269	broad.mit.edu	37	1	42047178	42047178	+	Silent	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:42047178T>A	uc001cgz.3	-	4	4504	c.3291A>T	c.(3289-3291)GGA>GGT	p.G1097G	HIVEP3_uc001cha.3_Silent_p.G1097G|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1097					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTCCCGGGGGTCCACCATGTG	0.612000													7	54					0	0	1	0	0	
ELOVL1	64834	broad.mit.edu	37	1	43831048	43831048	+	Splice_Site	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:43831048C>T	uc001ciz.2	-	4	290	c.47_splice	c.e4-1	p.D16_splice	ELOVL1_uc001cja.2_Splice_Site_p.D16_splice|ELOVL1_uc001cjb.2_Splice_Site_p.D16_splice|ELOVL1_uc001cjc.2_Splice_Site|ELOVL1_uc010okh.1_Splice_Site_p.D16_splice	NM_022821	NP_073732	Q9BW60	ELOV1_HUMAN	elongation of very long chain fatty acids-like						fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding				0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATCCGGGGATCTATGAATAAG	0.517000													11	6					0	0	1	0	0	
ST3GAL3	6487	broad.mit.edu	37	1	44202014	44202014	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:44202014G>A	uc001ckc.2	+	2	258	c.81G>A	c.(79-81)GCG>GCA	p.A27A	ST3GAL3_uc009vwu.1_RNA|ST3GAL3_uc010okj.1_RNA|ST3GAL3_uc001cjz.2_Silent_p.A27A|ST3GAL3_uc001cka.2_Silent_p.A27A|ST3GAL3_uc001ckb.2_Silent_p.A27A|ST3GAL3_uc001ckd.2_Silent_p.A27A|ST3GAL3_uc001cke.2_Silent_p.A27A|ST3GAL3_uc001ckf.2_Silent_p.A27A|ST3GAL3_uc001ckg.2_Silent_p.A27A|ST3GAL3_uc001ckh.2_Silent_p.A27A|ST3GAL3_uc001cki.2_Silent_p.A27A|ST3GAL3_uc009vwv.2_Silent_p.A27A|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_RNA|ST3GAL3_uc001ckk.2_Silent_p.A27A|ST3GAL3_uc009vwy.2_Translation_Start_Site|ST3GAL3_uc009vwx.2_RNA|ST3GAL3_uc001ckm.2_Silent_p.A27A|ST3GAL3_uc001ckl.2_Silent_p.A27A|ST3GAL3_uc009vwz.2_Translation_Start_Site|ST3GAL3_uc001ckn.2_RNA|ST3GAL3_uc001ckp.2_Silent_p.A27A|ST3GAL3_uc001cko.2_Silent_p.A27A|ST3GAL3_uc009vxa.2_Translation_Start_Site|ST3GAL3_uc001ckq.2_Silent_p.A27A|ST3GAL3_uc001ckr.2_Silent_p.A27A|ST3GAL3_uc009vxb.2_Silent_p.A27A	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	27	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				ATTATTCTGCGTGGAAGCTAC	0.468000													60	64					0	0	1	0	0	
KIF2C	11004	broad.mit.edu	37	1	45226082	45226082	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:45226082G>A	uc001cmg.3	+	15	1613	c.1498G>A	c.(1498-1500)GCG>ACG	p.A500T	KIF2C_uc010olb.1_Missense_Mutation_p.A459T|KIF2C_uc010olc.1_Missense_Mutation_p.A387T|KIF2C_uc001cmh.3_Missense_Mutation_p.A446T	NM_006845	NP_006836	Q99661	KIF2C_HUMAN	kinesin family member 2C	500	Kinesin-motor.				blood coagulation|cell division|cell proliferation|chromosome segregation|establishment or maintenance of microtubule cytoskeleton polarity|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|kinesin complex|microtubule|nucleus	ATP binding|centromeric DNA binding|microtubule motor activity|microtubule plus-end binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TGAGCGAGGCGCGGACACTTC	0.557000													20	20					0	0	1	0	0	
MKNK1	8569	broad.mit.edu	37	1	47024370	47024370	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:47024370C>A	uc001cqb.2	-	14	1519	c.1275G>T	c.(1273-1275)GAG>GAT	p.E425D	MKNK1_uc010omd.1_Missense_Mutation_p.E289D|MKNK1_uc001cqc.2_Missense_Mutation_p.E384D|MKNK1_uc009vyi.2_3'UTR|MKNK1_uc010ome.1_3'UTR	NM_003684	NP_003675	Q9BUB5	MKNK1_HUMAN	MAP kinase-interacting serine/threonine kinase 1	425					intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2	Acute lymphoblastic leukemia(166;0.155)					CAGCTAGTGCCTCTGGCTCCT	0.617000													31	44					2.61193e-14	2.76265e-14	1	1	0	
MOBKL2C	148932	broad.mit.edu	37	1	47078650	47078650	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:47078650G>A	uc001cqf.3	-	2	575	c.344C>T	c.(343-345)CCG>CTG	p.P115L	MKNK1_uc010omf.1_Intron|MOBKL2C_uc001cqe.3_Missense_Mutation_p.P167L	NM_201403	NP_958805	Q70IA8	MOL2C_HUMAN	MOB1, Mps One Binder kinase activator-like 2C	115							metal ion binding			pancreas(1)	1	Acute lymphoblastic leukemia(166;0.155)					CATATAGCGCGGCGCAGAGAG	0.657000													19	32					0	0	1	0	0	
SSBP3	23648	broad.mit.edu	37	1	54694479	54694479	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:54694479C>T	uc001cxe.2	-	15	1246	c.948G>A	c.(946-948)TCG>TCA	p.S316S	SSBP3_uc001cxf.2_Silent_p.S296S|SSBP3_uc001cxg.2_Silent_p.S289S|SSBP3_uc001cxd.2_Silent_p.S5S	NM_145716	NP_663768	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3 isoform a	316	Gly-rich.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0						TCGGACCGTCCGAGCCGGGAC	0.687000													7	14					0	0	1	0	0	
PCSK9	255738	broad.mit.edu	37	1	55524222	55524222	+	Missense_Mutation	SNP	C	T	T	rs141502002	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:55524222C>T	uc001cyf.1	+	9	1696	c.1405C>T	c.(1405-1407)CGG>TGG	p.R469W	PCSK9_uc010oom.1_RNA	NM_174936	NP_777596	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	469			R -> W.		cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GGGGCCTACACGGATGGCCAC	0.647000													13	46					0	0	1	0	0	
PRKAA2	5563	broad.mit.edu	37	1	57169680	57169680	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:57169680C>T	uc001cyk.3	+	7	896	c.825C>T	c.(823-825)TAC>TAT	p.Y275Y		NM_006252	NP_006243	P54646	AAPK2_HUMAN	AMP-activated protein kinase alpha 2 catalytic	275					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(4)|ovary(1)|stomach(1)	6						TGCCCAGTTACTTATTTCCTG	0.353000													63	101					0	0	1	0	0	
C1orf168	199920	broad.mit.edu	37	1	57258264	57258264	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:57258264A>G	uc001cym.3	-	2	628	c.222T>C	c.(220-222)CTT>CTC	p.L74L	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.L74L	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	74										ovary(3)|skin(2)	5						TCTGAGGTTGAAGAGGCTGGG	0.468000													53	72					0	0	1	0	0	
DAB1	1600	broad.mit.edu	37	1	57480759	57480759	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:57480759G>A	uc001cys.1	-	14	1915	c.1241C>T	c.(1240-1242)ACG>ATG	p.T414M	DAB1_uc001cyt.1_Missense_Mutation_p.T412M|DAB1_uc001cyq.1_Missense_Mutation_p.T412M|DAB1_uc001cyr.1_Missense_Mutation_p.T328M|DAB1_uc009vzw.1_Missense_Mutation_p.T396M|DAB1_uc009vzx.1_Missense_Mutation_p.T414M	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	447					cell differentiation|nervous system development					skin(2)|ovary(1)	3						ATCCTTAAACGTTTCTTTGCC	0.607000													17	50					0	0	1	0	0	
FGGY	55277	broad.mit.edu	37	1	59978070	59978070	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:59978070C>T	uc001czi.3	+	7	970	c.758C>T	c.(757-759)GCG>GTG	p.A253V	FGGY_uc001czg.2_Missense_Mutation_p.A141V|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.A253V|FGGY_uc001czj.3_Missense_Mutation_p.A253V|FGGY_uc001czk.3_Missense_Mutation_p.A141V|FGGY_uc001czl.3_Missense_Mutation_p.A165V	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	253					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					CCTGGGATTGCGGTCGCAGCT	0.498000													44	54					0	0	1	0	0	
C1orf87	127795	broad.mit.edu	37	1	60491137	60491137	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:60491137G>A	uc001czs.1	-	8	1155	c.1063C>T	c.(1063-1065)CTG>TTG	p.L355L		NM_152377	NP_689590	Q8N0U7	CA087_HUMAN	hypothetical protein LOC127795	355							calcium ion binding			ovary(1)|breast(1)	2						CTCAGGGTCAGATATAATCCA	0.294000													33	52					0	0	1	0	0	
DOCK7	85440	broad.mit.edu	37	1	62961311	62961311	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:62961311A>T	uc001daq.2	-	39	4972	c.4938T>A	c.(4936-4938)GAT>GAA	p.D1646E	DOCK7_uc001dan.2_Missense_Mutation_p.D1507E|DOCK7_uc001dao.2_Missense_Mutation_p.D1507E|DOCK7_uc001dap.2_Missense_Mutation_p.D1624E|DOCK7_uc001dam.2_Missense_Mutation_p.D826E|DOCK7_uc010oov.1_Missense_Mutation_p.D385E	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1655	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						TTTTCACAGTATCAGAAAGAA	0.348000													14	41					0	0	1	0	0	
ALG6	29929	broad.mit.edu	37	1	63876980	63876980	+	Nonsense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:63876980A>T	uc010oow.1	+	8	963	c.658A>T	c.(658-660)AAA>TAA	p.K220*	ALG6_uc001daz.2_RNA|ALG6_uc009waj.2_RNA|ALG6_uc010oox.1_Nonsense_Mutation_p.K19*	NM_013339	NP_037471	Q9Y672	ALG6_HUMAN	dolichyl pyrophosphate Man9GlcNAc2	220					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity				0						CAAGTGTTTTAAAAAAGGCCT	0.353000													21	35					0	0	1	0	0	
EFCAB7	84455	broad.mit.edu	37	1	64027499	64027499	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:64027499G>T	uc001dbf.2	+	11	1762	c.1468G>T	c.(1468-1470)GGC>TGC	p.G490C		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	490							calcium ion binding				0						ACACTCTATGGGCTACAATAA	0.348000													15	26					2.48551e-13	2.61948e-13	1	1	0	
IL12RB2	3595	broad.mit.edu	37	1	67861595	67861595	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:67861595C>T	uc001ddu.2	+	16	3052	c.2412C>T	c.(2410-2412)AAC>AAT	p.N804N	IL12RB2_uc010oqi.1_3'UTR|IL12RB2_uc010oqj.1_3'UTR|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Silent_p.N718N|IL12RB2_uc010oqm.1_3'UTR|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	804	Cytoplasmic (Potential).			N->A: No effect on in vitro STAT4 binding to a phosphorylated Y-800 peptide.	positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						TACCCTCCAACATAGATGACC	0.572000													97	145					0	0	1	0	0	
LRRIQ3	127255	broad.mit.edu	37	1	74649219	74649219	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:74649219G>A	uc001dfy.3	-	2	342	c.150C>T	c.(148-150)ATC>ATT	p.I50I	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	50										ovary(2)	2						ctctaagagagatgcaagact	0.154000													14	23					0	0	1	0	0	
ST6GALNAC3	256435	broad.mit.edu	37	1	76779524	76779524	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:76779524C>T	uc001dhh.2	+	2	216	c.53C>T	c.(52-54)GCG>GTG	p.A18V	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.A18V|ST6GALNAC3_uc010orh.1_Intron	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	18	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						TTCATAGCAGCGTTCCTTTTC	0.403000													25	47					0	0	1	0	0	
IFI44L	10964	broad.mit.edu	37	1	79102859	79102859	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:79102859A>G	uc010oro.1	+	6	1198	c.1019A>G	c.(1018-1020)AAG>AGG	p.K340R	IFI44L_uc010orp.1_Missense_Mutation_p.K77R|IFI44L_uc010orq.1_Missense_Mutation_p.K77R	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	340						cytoplasm					0						GCAAAAGTGAAGCAAGTTCAC	0.289000													25	38					0	0	1	0	0	
TGFBR3	7049	broad.mit.edu	37	1	92178028	92178028	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:92178028G>A	uc001doh.2	-	13	2404	c.1938C>T	c.(1936-1938)AAC>AAT	p.N646N	TGFBR3_uc009wde.2_Intron|TGFBR3_uc010osy.1_Silent_p.N604N|TGFBR3_uc001doi.2_Silent_p.N645N|TGFBR3_uc001doj.2_Silent_p.N645N	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	646	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TCCTATCAGGGTTCGAATATG	0.393000													39	56					0	0	1	0	0	
EVI5	7813	broad.mit.edu	37	1	93202119	93202119	+	Silent	SNP	C	T	T	rs140717428		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:93202119C>T	uc001dox.2	-	2	127	c.117G>A	c.(115-117)TCG>TCA	p.S39S	EVI5_uc010otf.1_Silent_p.S39S	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	39	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		TGACTGTATGCGATACTGTGT	0.438000													54	94					0	0	1	0	0	
MTF2	22823	broad.mit.edu	37	1	93599728	93599728	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:93599728C>A	uc009wdj.2	+	14	1692	c.1400C>A	c.(1399-1401)TCG>TAG	p.S467*	MTF2_uc010oth.1_Nonsense_Mutation_p.S365*|MTF2_uc009wdk.2_Nonsense_Mutation_p.S410*|MTF2_uc001dpi.3_Nonsense_Mutation_p.S194*|MTF2_uc010oti.1_Nonsense_Mutation_p.S365*|MTF2_uc001dpj.3_Nonsense_Mutation_p.S365*|MTF2_uc001dpl.3_Nonsense_Mutation_p.S365*|MTF2_uc001dpm.3_Nonsense_Mutation_p.S136*	NM_007358	NP_031384	Q9Y483	MTF2_HUMAN	metal response element binding transcription	467						nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_lung(203;0.00196)|Lung NSC(277;0.00902)|Melanoma(281;0.099)|Ovarian(761;0.109)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00076)|GBM - Glioblastoma multiforme(16;0.00157)|Epithelial(280;0.0886)		GAAACTACCTCGTCTAGCATT	0.343000													30	36					3.90053e-15	4.13625e-15	1	1	0	
AGL	178	broad.mit.edu	37	1	100330058	100330058	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:100330058A>G	uc001dsi.1	+	5	977	c.577A>G	c.(577-579)ACC>GCC	p.T193A	AGL_uc001dsj.1_Missense_Mutation_p.T193A|AGL_uc001dsk.1_Missense_Mutation_p.T193A|AGL_uc001dsl.1_Missense_Mutation_p.T193A|AGL_uc001dsm.1_Missense_Mutation_p.T177A|AGL_uc001dsn.1_Missense_Mutation_p.T176A	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	193	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TAGAAAGTATACCTGGAATGA	0.358000													44	59					0	0	1	0	0	
LRRC39	127495	broad.mit.edu	37	1	100618013	100618013	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:100618013C>T	uc001dsw.1	-	9	1079	c.880G>A	c.(880-882)GAA>AAA	p.E294K	LRRC39_uc001dsx.1_Missense_Mutation_p.E294K|LRRC39_uc001dsy.1_Missense_Mutation_p.E294K|LRRC39_uc001dsz.1_Missense_Mutation_p.E294K	NM_144620	NP_653221	Q96DD0	LRC39_HUMAN	leucine rich repeat containing 39	294	Poly-Glu.									ovary(2)|skin(1)	3		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0826)|all cancers(265;0.135)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		TCCTCTTCTTCATCTGTGCCT	0.373000													70	82					0	0	1	0	0	
RTCD1	8634	broad.mit.edu	37	1	100756997	100756997	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:100756997C>T	uc001dtc.2	+	11	1256	c.1038C>T	c.(1036-1038)GAC>GAT	p.D346D	RTCD1_uc001dtd.2_Silent_p.D359D	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform	346					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		ATGAAGAAGACGCCGCTAAAG	0.343000													49	84					0	0	1	0	0	
S1PR1	1901	broad.mit.edu	37	1	101705418	101705418	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:101705418C>T	uc001dud.2	+	2	1392	c.878C>T	c.(877-879)GCG>GTG	p.A293V	S1PR1_uc009weg.2_Missense_Mutation_p.A293V	NM_001400	NP_001391	P21453	S1PR1_HUMAN	sphingosine-1-phosphate receptor 1	293	Extracellular (By similarity).				cell adhesion	integral to membrane	lysosphingolipid and lysophosphatidic acid receptor activity			ovary(2)|lung(1)	3						CTCTTCAGAGCGGAGTACTTC	0.562000													100	174					0	0	1	0	0	
COL11A1	1301	broad.mit.edu	37	1	103491152	103491152	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:103491152A>G	uc001dul.2	-	7	1233	c.915T>C	c.(913-915)GAT>GAC	p.D305D	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Silent_p.D317D|COL11A1_uc001dun.2_Silent_p.D266D|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	305	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATTCTTGAAAATCATCAACGA	0.338000													20	29					0	0	1	0	0	
AMY2B	280	broad.mit.edu	37	1	104120145	104120145	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:104120145A>G	uc001duq.2	+	10	1751	c.1135A>G	c.(1135-1137)AAT>GAT	p.N379D	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.N379D|AMY2B_uc001dus.1_RNA	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	379					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		ACCAAATAATAATGGAGTAAT	0.363000													55	111					0	0	1	0	0	
AMY2B	280	broad.mit.edu	37	1	104120389	104120389	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:104120389A>G	uc001duq.2	+	11	1884	c.1268A>G	c.(1267-1269)AAC>AGC	p.N423S	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.N423S|AMY2B_uc001dus.1_RNA	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	423					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		CCTTTTACAAACTGGTATGAT	0.348000													84	130					0	0	1	0	0	
AMY2A	279	broad.mit.edu	37	1	104162293	104162293	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:104162293C>A	uc001dut.2	+	4	695	c.631C>A	c.(631-633)CTT>ATT	p.L211I	AMY2A_uc010ouq.1_Missense_Mutation_p.L211I	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	211					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	AGGGTTCAGACTTGATGCTTC	0.433000													20	256					9.93527e-08	1.02395e-07	1	1	0	
EPS8L3	79574	broad.mit.edu	37	1	110300588	110300588	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:110300588C>T	uc001dyr.1	-	9	955	c.810G>A	c.(808-810)GGG>GGA	p.G270G	EPS8L3_uc001dys.1_Silent_p.G270G|EPS8L3_uc001dyq.1_Silent_p.G271G|EPS8L3_uc009wfm.1_Silent_p.G237G|EPS8L3_uc009wfn.1_Silent_p.G245G|EPS8L3_uc009wfo.1_Silent_p.G217G	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	270						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		TGTTTTTTTTCCCAAATTTCT	0.557000													10	90					0	0	1	0	0	
KCNA3	3738	broad.mit.edu	37	1	111216137	111216137	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:111216137G>A	uc001dzv.1	-	1	1519	c.1295C>T	c.(1294-1296)CCG>CTG	p.P432L		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	432						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAAGGCATCCGGGATGCTGCT	0.547000													18	27					0	0	1	0	0	
KCNA3	3738	broad.mit.edu	37	1	111217309	111217309	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:111217309C>T	uc001dzv.1	-	1	347	c.123G>A	c.(121-123)GCG>GCA	p.A41A		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	41						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGGCGGGCTCCGCGTAGCCGT	0.781000													7	4					0	0	1	0	0	
MAGI3	260425	broad.mit.edu	37	1	114225544	114225544	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:114225544G>A	uc001edk.2	+	21	3535	c.3354G>A	c.(3352-3354)TCG>TCA	p.S1118S	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1143					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATAATCCTTCGTCTTCAAATG	0.318000													9	26					0	0	1	0	0	
SLC22A15	55356	broad.mit.edu	37	1	116534699	116534699	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:116534699G>A	uc001egb.3	+	2	265	c.135G>A	c.(133-135)ACG>ACA	p.T45T	SLC22A15_uc001ega.2_Silent_p.T45T	NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	45					ion transport	integral to membrane	transmembrane transporter activity	p.T45M(1)		large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTGGGGCCACGCCATCCTACC	0.557000													19	18					0	0	1	0	0	
IGSF3	3321	broad.mit.edu	37	1	117150572	117150572	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:117150572A>G	uc001egr.1	-	5	1919	c.1214T>C	c.(1213-1215)CTC>CCC	p.L405P	IGSF3_uc001egq.1_Missense_Mutation_p.L405P|IGSF3_uc001egs.1_Missense_Mutation_p.L78P	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	405	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		ACTGAGGGGGAGGACTATGAT	0.517000													47	68					0	0	1	0	0	
IGSF3	3321	broad.mit.edu	37	1	117150721	117150721	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:117150721G>A	uc001egr.1	-	5	1770	c.1065C>T	c.(1063-1065)AGC>AGT	p.S355S	IGSF3_uc001egq.1_Silent_p.S355S|IGSF3_uc001egs.1_Silent_p.S28S	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	355	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AGACACTGTCGCTCTCTTTGG	0.567000													34	66					0	0	1	0	0	
IGSF3	3321	broad.mit.edu	37	1	117150811	117150811	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:117150811G>A	uc001egr.1	-	5	1680	c.975C>T	c.(973-975)ATC>ATT	p.I325I	IGSF3_uc001egq.1_Silent_p.I325I|IGSF3_uc001egs.1_5'UTR	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	325	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CCATGGTGGCGATGAGCGAGC	0.582000													11	8					0	0	1	0	0	
HAO2	51179	broad.mit.edu	37	1	119923812	119923812	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:119923812G>A	uc001ehq.1	+	3	456	c.104G>A	c.(103-105)CGG>CAG	p.R35Q	HAO2_uc001ehr.1_Missense_Mutation_p.R35Q	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	35	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		AGCATCACGCGGGATGACAAC	0.483000													49	80					0	0	1	0	0	
HMGCS2	3158	broad.mit.edu	37	1	120302555	120302555	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:120302555C>T	uc001eid.2	-	3	668	c.617G>A	c.(616-618)CGT>CAT	p.R206H	HMGCS2_uc010oxj.1_Intron|HMGCS2_uc001eie.2_Missense_Mutation_p.R114H	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	206					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		ACCTGTGGGACGAGCATTACC	0.517000													24	35					0	0	1	0	0	
NOTCH2	4853	broad.mit.edu	37	1	120539712	120539712	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:120539712C>T	uc001eik.2	-	4	915	c.659G>A	c.(658-660)AGC>AAC	p.S220N	NOTCH2_uc001eil.2_Missense_Mutation_p.S220N|NOTCH2_uc001eim.3_Missense_Mutation_p.S137N	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	220	Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACATACAGGCTGTCACAGTA	0.577000			N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				23	39					0	0	1	0	0	
NBPF9	400818	broad.mit.edu	37	1	144621649	144621649	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:144621649C>G	uc009wig.1	+	9	1057	c.981C>G	c.(979-981)AAC>AAG	p.N327K	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Missense_Mutation_p.N327K|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_Missense_Mutation_p.N258K|NBPF9_uc001eli.3_RNA|NBPF9_uc010oyf.1_Missense_Mutation_p.N258K|NBPF9_uc010oyg.1_Missense_Mutation_p.N292K|NBPF9_uc009wii.1_Missense_Mutation_p.N56K	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	327						cytoplasm					0						ACCAGCAGAACAAATACAGTA	0.428000													52	148					0	0	1	0	0	
PIAS3	10401	broad.mit.edu	37	1	145581207	145581207	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:145581207T>C	uc001eoc.1	+	8	1027	c.936T>C	c.(934-936)CCT>CCC	p.P312P	NBPF10_uc001emp.3_Intron|PIAS3_uc001eod.1_5'UTR	NM_006099	NP_006090	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	312	SP-RING-type.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTGCTGACCCTGACAGTGAGG	0.562000													18	32					0	0	1	0	0	
BCL9	607	broad.mit.edu	37	1	147096166	147096166	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:147096166C>T	uc001epq.2	+	10	4427	c.3687C>T	c.(3685-3687)ACC>ACT	p.T1229T	BCL9_uc010ozr.1_Silent_p.T1143T	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	1229	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CTGGAGCCACCGGAATACCTG	0.567000			T	IGH@|IGL@	B-ALL								33	63					0	0	1	0	0	
SV2A	9900	broad.mit.edu	37	1	149882489	149882489	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:149882489C>G	uc001etg.2	-	4	1335	c.844G>C	c.(844-846)GAG>CAG	p.E282Q	SV2A_uc001eth.2_Missense_Mutation_p.E282Q	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	282	Helical; (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	GCCAGAAACTCGGAGAAATAG	0.522000													11	26					0	0	1	0	0	
RPRD2	23248	broad.mit.edu	37	1	150445057	150445057	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:150445057G>A	uc009wlr.2	+	11	3834	c.3633G>A	c.(3631-3633)GGG>GGA	p.G1211G	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Silent_p.G1185G	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1211	Pro-rich.						protein binding			ovary(1)	1						AGCCAGTGGGGCCATCATCTG	0.532000													4	76					0	0	1	0	0	
ADAMTSL4	54507	broad.mit.edu	37	1	150525976	150525976	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:150525976G>A	uc001eux.2	+	6	745	c.509G>A	c.(508-510)CGG>CAG	p.R170Q	ADAMTSL4_uc001euw.2_Missense_Mutation_p.R170Q|ADAMTSL4_uc009wlw.2_Missense_Mutation_p.R170Q|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.R170Q	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	170					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CCACTGCACCGGAACCGCAGG	0.587000													27	56					0	0	1	0	0	
POGZ	23126	broad.mit.edu	37	1	151397495	151397495	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:151397495C>T	uc001eyd.1	-	8	1427	c.1121G>A	c.(1120-1122)CGG>CAG	p.R374Q	POGZ_uc001eye.1_Missense_Mutation_p.R321Q|POGZ_uc010pdb.1_Missense_Mutation_p.R365Q|POGZ_uc001eyf.1_Missense_Mutation_p.R321Q|POGZ_uc010pdc.1_Missense_Mutation_p.R312Q|POGZ_uc009wmv.1_Missense_Mutation_p.R279Q|POGZ_uc010pdd.1_Intron	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	374					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ACATATTTTCCGTCCACCATC	0.403000													4	7					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	1	151994944	151994944	+	RNA	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:151994944C>T	uc001ezm.1	+	12		c.2878C>T								Homo sapiens cDNA FLJ43896 fis, clone TESTI4009752.																		ACGATGTTTACGTTGAGGAGG	0.418000													9	17					0	0	1	0	0	
FLG	2312	broad.mit.edu	37	1	152283170	152283170	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:152283170T>G	uc001ezu.1	-	3	4228	c.4192A>C	c.(4192-4194)AGT>CGT	p.S1398R	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1398	Ser-rich.|Filaggrin 8.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCCTCACTGTTAGTGACC	0.567000									Ichthyosis				156	220					0	0	1	0	0	
FLG	2312	broad.mit.edu	37	1	152285339	152285339	+	Missense_Mutation	SNP	C	A	A	rs140188504		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:152285339C>A	uc001ezu.1	-	3	2059	c.2023G>T	c.(2023-2025)GAC>TAC	p.D675Y	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	675	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAGCTGTCTGCAGAGTGC	0.527000									Ichthyosis				158	253					7.9336e-59	8.62238e-59	1	1	0	
CRCT1	54544	broad.mit.edu	37	1	152488062	152488062	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:152488062G>A	uc001ezz.2	+	2	276	c.203G>A	c.(202-204)CGC>CAC	p.R68H		NM_019060	NP_061933	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	68	Cys-rich.										0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGGAGACGCCGCCGACAGCGG	0.652000													6	6					0	0	1	0	0	
ILF2	3608	broad.mit.edu	37	1	153640491	153640491	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:153640491T>C	uc001fcr.2	-	5	357	c.276A>G	c.(274-276)CCA>CCG	p.P92P	ILF2_uc010pdy.1_Silent_p.P54P|ILF2_uc009wok.2_Silent_p.P92P|ILF2_uc009wol.1_Silent_p.P54P	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	92					immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAAATGTCCCTGGAGCCACAA	0.348000													28	46					0	0	1	0	0	
ATP8B2	57198	broad.mit.edu	37	1	154302929	154302929	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:154302929C>T	uc001fey.1	+	2	335	c.146C>T	c.(145-147)GCG>GTG	p.A49V	ATP8B2_uc001few.2_Missense_Mutation_p.A30V|ATP8B2_uc001fex.2_Missense_Mutation_p.A63V	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	49	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TTCCAGTATGCGGTAAGCGAC	0.527000													27	46					0	0	1	0	0	
SHE	126669	broad.mit.edu	37	1	154461771	154461771	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:154461771G>T	uc001ffb.2	-	3	867	c.780C>A	c.(778-780)CCC>CCA	p.P260P	SHE_uc001ffc.2_RNA	NM_001010846	NP_001010846	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	260										breast(3)|ovary(2)|central_nervous_system(1)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CGGGTTCACAGGGACTGTCAA	0.527000													41	59					4.67007e-22	5.0066e-22	1	1	0	
CHRNB2	1141	broad.mit.edu	37	1	154544057	154544057	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:154544057T>C	uc001ffg.2	+	5	1022	c.758T>C	c.(757-759)ATC>ACC	p.I253T		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	253	Helical; (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	TCGCTAGCCATCCTTGTCTTC	0.542000													56	74					0	0	1	0	0	
DCST1	149095	broad.mit.edu	37	1	155015874	155015874	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155015874G>A	uc001fgn.1	+	10	1157	c.1061G>A	c.(1060-1062)CGC>CAC	p.R354H	DCST1_uc010per.1_Missense_Mutation_p.R379H|DCST1_uc010pes.1_Missense_Mutation_p.R329H	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	354	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			AGCTGGGAGCGCGTGAGCACC	0.667000													19	51					0	0	1	0	0	
EFNA4	1945	broad.mit.edu	37	1	155041446	155041446	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155041446G>A	uc001fhd.2	+	4	674	c.587G>A	c.(586-588)CGT>CAT	p.R196H	EFNA3_uc010pew.1_Intron|EFNA4_uc001fhc.2_Intron|EFNA4_uc001fhe.2_Intron	NM_005227	NP_005218	P52798	EFNA4_HUMAN	ephrin A4 isoform a	196					cell-cell signaling	anchored to membrane|extracellular region|integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity				0	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CTGATTCTTCGTCTTCTGCGA	0.597000													37	61					0	0	1	0	0	
MUC1	4582	broad.mit.edu	37	1	155160514	155160514	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155160514C>T	uc010pfj.1	-	3	945	c.539G>A	c.(538-540)GGT>GAT	p.G180D	RAG1AP1_uc010pey.1_Intron|MUC1_uc001fhy.2_Missense_Mutation_p.G10D|MUC1_uc001fhz.2_Missense_Mutation_p.G10D|MUC1_uc010pfb.1_Missense_Mutation_p.G10D|MUC1_uc010pfc.1_RNA|MUC1_uc009wph.2_Missense_Mutation_p.G10D|MUC1_uc010pfd.1_Missense_Mutation_p.V78I|MUC1_uc010pfe.1_Intron|MUC1_uc010pff.1_Missense_Mutation_p.V134I|MUC1_uc009wpi.2_Missense_Mutation_p.G10D|MUC1_uc010pfg.1_RNA|MUC1_uc010pfh.1_Missense_Mutation_p.G156D|MUC1_uc010pfi.1_Missense_Mutation_p.G156D|MUC1_uc010pfk.1_RNA|MUC1_uc010pfl.1_RNA|MUC1_uc001fin.2_Intron|MUC1_uc009wpk.2_Missense_Mutation_p.V34I|MUC1_uc001fip.2_Missense_Mutation_p.V60I|MUC1_uc009wqg.2_Intron|MUC1_uc009wpo.2_Missense_Mutation_p.G47D|MUC1_uc009wps.2_Missense_Mutation_p.G68D|MUC1_uc009wpt.2_Missense_Mutation_p.G71D|MUC1_uc001fic.2_Missense_Mutation_p.G59D|MUC1_uc009wpu.2_Intron|MUC1_uc009wpq.2_Missense_Mutation_p.G73D|MUC1_uc009wpv.2_Missense_Mutation_p.V60I|MUC1_uc001fim.2_Intron|MUC1_uc001fib.2_Missense_Mutation_p.V60I|MUC1_uc009wpw.2_Intron|MUC1_uc001fie.2_Intron|MUC1_uc009wpr.2_Intron|MUC1_uc001fig.2_Intron|MUC1_uc001fif.2_Intron|MUC1_uc009wpx.2_Intron|MUC1_uc001fid.2_Intron|MUC1_uc009wpj.2_Intron|MUC1_uc001fij.2_Missense_Mutation_p.G94D|MUC1_uc009wpy.2_Intron|MUC1_uc010pfm.1_Missense_Mutation_p.G10D|MUC1_uc001fiq.2_Missense_Mutation_p.G10D|MUC1_uc009wpz.2_Missense_Mutation_p.G112D|MUC1_uc010pfn.1_Missense_Mutation_p.G85D|MUC1_uc009wqa.2_Missense_Mutation_p.G168D|MUC1_uc010pfo.1_Missense_Mutation_p.V78I|MUC1_uc010pfp.1_Missense_Mutation_p.V78I|MUC1_uc001fii.2_Intron|MUC1_uc001fih.2_Intron|MUC1_uc001fia.2_Missense_Mutation_p.G85D|MUC1_uc009wqc.2_Missense_Mutation_p.G82D|MUC1_uc009wqd.2_Missense_Mutation_p.G106D|MUC1_uc009wqb.2_Missense_Mutation_p.G10D|MUC1_uc010pfq.1_Missense_Mutation_p.G82D|MUC1_uc010pfr.1_Missense_Mutation_p.V88I|MUC1_uc001fit.2_Missense_Mutation_p.G10D|MUC1_uc009wqe.2_Intron|MUC1_uc001fil.2_Missense_Mutation_p.V79I|MUC1_uc009wpm.2_Missense_Mutation_p.G103D|MUC1_uc009wpp.2_Missense_Mutation_p.V79I|MUC1_uc010pfs.1_RNA|MUC1_uc001fik.2_Missense_Mutation_p.G103D|MUC1_uc001fio.2_Missense_Mutation_p.V79I|MUC1_uc009wqf.2_Intron|MUC1_uc009wpl.2_Intron|MUC1_uc009wpn.2_Missense_Mutation_p.G94D|MUC1_uc001fis.1_Intron			P15941	MUC1_HUMAN	SubName: Full=Mucin 1, cell surface associated;	1085	Extracellular (Potential).|SEA.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCCCAGAAAACCCCCTTGTTT	0.527000			T	IGH@	B-NHL								50	82					0	0	1	0	0	
PKLR	5313	broad.mit.edu	37	1	155265256	155265256	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155265256G>A	uc001fkb.3	-	4	518	c.479C>T	c.(478-480)CCG>CTG	p.P160L	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Missense_Mutation_p.P129L|PKLR_uc010pga.1_Missense_Mutation_p.P96L	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	160					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GCGGATCTCCGGTCCCTTGGT	0.692000													8	5					0	0	1	0	0	
RUSC1	23623	broad.mit.edu	37	1	155296779	155296779	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155296779G>A	uc001fkj.2	+	8	2499	c.2270G>A	c.(2269-2271)CGT>CAT	p.R757H	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Missense_Mutation_p.R651H|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_Missense_Mutation_p.R288H|RUSC1_uc001fkl.2_Missense_Mutation_p.R347H|RUSC1_uc001fkp.2_Missense_Mutation_p.R288H|RUSC1_uc001fkq.2_Missense_Mutation_p.R182H|RUSC1_uc010pgb.1_Missense_Mutation_p.R255H|RUSC1_uc009wqp.1_Missense_Mutation_p.R282H|RUSC1_uc001fkn.2_Missense_Mutation_p.R66H|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Missense_Mutation_p.R288H|RUSC1_uc001fks.2_Missense_Mutation_p.R66H	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	757						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			GCACCGGGGCGTCATGGGACT	0.632000													38	57					0	0	1	0	0	
ASH1L	55870	broad.mit.edu	37	1	155448107	155448107	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155448107T>G	uc009wqq.2	-	3	5034	c.4554A>C	c.(4552-4554)AGA>AGC	p.R1518S	ASH1L_uc001fkt.2_Missense_Mutation_p.R1518S|ASH1L_uc009wqr.1_Missense_Mutation_p.R1518S	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1518					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CCTTTCCAAATCTATAGCGCT	0.453000													39	49					0	0	1	0	0	
SEMA4A	64218	broad.mit.edu	37	1	156132858	156132858	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:156132858C>T	uc001fnl.2	+	10	1211	c.1107C>T	c.(1105-1107)GGC>GGT	p.G369G	SEMA4A_uc009wrq.2_Silent_p.G369G|SEMA4A_uc001fnm.2_Silent_p.G369G|SEMA4A_uc001fnn.2_Silent_p.G237G|SEMA4A_uc001fno.2_Silent_p.G369G	NM_022367	NP_071762	Q9H3S1	SEM4A_HUMAN	semaphorin B precursor	369	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.158)					CTTATAGGGGCCCTGAGACCA	0.478000													19	53					0	0	1	0	0	
RHBG	57127	broad.mit.edu	37	1	156347148	156347148	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:156347148C>A	uc010pho.1	+	2	282	c.244C>A	c.(244-246)CTG>ATG	p.L82M	RHBG_uc010phm.1_Intron|RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_Missense_Mutation_p.L13M|RHBG_uc009wrz.2_Missense_Mutation_p.L13M|RHBG_uc001for.2_Missense_Mutation_p.L52M	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	82	Helical; (Potential).				transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					CATGGTCTTCCTGCAGCGTTA	0.632000													64	115					1.15062e-32	1.24721e-32	1	1	0	
CD1C	911	broad.mit.edu	37	1	158262642	158262642	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:158262642C>T	uc001fru.2	+	4	1159	c.867C>T	c.(865-867)GGC>GGT	p.G289G	CD1C_uc001frv.2_Silent_p.G92G	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	289	Extracellular (Potential).|Ig-like.				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					GTCTAGGAGGCCAGGACATCA	0.522000													18	27					0	0	1	0	0	
OR6K2	81448	broad.mit.edu	37	1	158670411	158670411	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:158670411T>C	uc001fsu.1	-	1	32	c.32A>G	c.(31-33)GAG>GGG	p.E11G		NM_001005279	NP_001005279	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					GAAGATAAACTCCTGAATGGT	0.448000													20	44					0	0	1	0	0	
IFI16	3428	broad.mit.edu	37	1	158986369	158986369	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:158986369A>G	uc001ftf.1	+	5	1035	c.428A>G	c.(427-429)AAG>AGG	p.K143R	IFI16_uc001ftg.2_Missense_Mutation_p.K143R|IFI16_uc010pis.1_Intron	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	143	Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					AAAGGGAGTAAGGTGTCCGAG	0.493000													8	23					0	0	1	0	0	
CRP	1401	broad.mit.edu	37	1	159683558	159683558	+	Silent	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:159683558A>C	uc001ftw.2	-	2	536	c.432T>G	c.(430-432)ACT>ACG	p.T144T	CRP_uc001ftx.1_Intron|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	144	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CTGCCCCCACAGTGTATCCCT	0.542000													139	215					0	0	1	0	0	
ATP1A2	477	broad.mit.edu	37	1	160098557	160098557	+	Missense_Mutation	SNP	C	T	T	rs28934002		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:160098557C>T	uc001fvc.2	+	9	1265	c.1133C>T	c.(1132-1134)ACC>ATC	p.T378I	ATP1A2_uc001fvb.2_Missense_Mutation_p.T378I|ATP1A2_uc010piz.1_Missense_Mutation_p.T223I|ATP1A2_uc001fvd.2_Missense_Mutation_p.T114I|ATP1A2_uc009wtg.1_Missense_Mutation_p.T66I	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	378	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AAGACGGGCACCCTCACCCAG	0.602000													26	51					0	0	1	0	0	
COPA	1314	broad.mit.edu	37	1	160275305	160275305	+	Missense_Mutation	SNP	G	A	A	rs144155845		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:160275305G>A	uc009wti.2	-	17	1979	c.1585C>T	c.(1585-1587)CGT>TGT	p.R529C	COPA_uc001fvv.3_Missense_Mutation_p.R538C|COPA_uc009wtj.1_Missense_Mutation_p.R475C	NM_004371	NP_004362	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha isoform	529					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			ovary(1)|skin(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTCTTGACACGAATGTTCTCA	0.443000													42	58					0	0	1	0	0	
FCRLA	84824	broad.mit.edu	37	1	161682964	161682964	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:161682964C>T	uc001gbe.2	+	6	1185	c.943C>T	c.(943-945)CCT>TCT	p.P315S	FCRLA_uc001gbd.2_Missense_Mutation_p.P309S|FCRLA_uc001gbf.2_Missense_Mutation_p.P220S|FCRLA_uc001gbg.2_Missense_Mutation_p.P169S|FCRLA_uc009wuo.2_Missense_Mutation_p.P175S|FCRLA_uc009wup.2_Missense_Mutation_p.P125S|FCRLA_uc009wuq.2_Missense_Mutation_p.P74S	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	292	Pro-rich.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GGCCCCTGGGCCTCTGCCTCC	0.567000													27	46					0	0	1	0	0	
FAM78B	149297	broad.mit.edu	37	1	166135339	166135339	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:166135339G>A	uc001gdr.2	-	2	737	c.147C>T	c.(145-147)TTC>TTT	p.F49F	FAM78B_uc010plc.1_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	49										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CGGAGGCTTTGAAGTAGGGGG	0.622000													4	14					0	0	1	0	0	
ADCY10	55811	broad.mit.edu	37	1	167839514	167839514	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:167839514C>A	uc001ger.2	-	14	1895	c.1597G>T	c.(1597-1599)GCC>TCC	p.A533S	ADCY10_uc009wvk.2_Missense_Mutation_p.A441S|ADCY10_uc010plj.1_Missense_Mutation_p.A380S|ADCY10_uc009wvl.2_Missense_Mutation_p.A532S	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	533					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TTACCTTGGGCCAGGTACTCA	0.378000													18	37					3.6726e-16	3.90464e-16	1	1	0	
ATP1B1	481	broad.mit.edu	37	1	169076064	169076064	+	RNA	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:169076064C>T	uc001gfs.1	+	1		c.118C>T						P05026	AT1B1_HUMAN	Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)					GACCCGCCATCGCCATGGCCC	0.672000													6	17					0	0	1	0	0	
CEP350	9857	broad.mit.edu	37	1	179965804	179965804	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:179965804G>A	uc001gnt.2	+	6	895	c.512G>A	c.(511-513)CGA>CAA	p.R171Q	CEP350_uc001gnr.1_Missense_Mutation_p.R145Q|CEP350_uc009wxl.2_Missense_Mutation_p.R170Q|CEP350_uc001gnu.2_Missense_Mutation_p.R5Q	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	171						centrosome|nucleus|spindle				ovary(4)	4						ATAGGCAGTCGAGAAGAACGG	0.408000													4	24					0	0	1	0	0	
LHX4	89884	broad.mit.edu	37	1	180243343	180243343	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:180243343G>A	uc001goe.1	+	6	1025	c.802G>A	c.(802-804)GGC>AGC	p.G268S	uc001gof.1_Intron	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	268						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CTCAGAACTTGGCCACACCAA	0.493000													47	74					0	0	1	0	0	
CACNA1E	777	broad.mit.edu	37	1	181706764	181706764	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:181706764G>A	uc001gow.2	+	23	3691	c.3526G>A	c.(3526-3528)GTC>ATC	p.V1176I	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1064I|CACNA1E_uc001gox.1_Missense_Mutation_p.V402I|CACNA1E_uc009wxt.2_Missense_Mutation_p.V402I	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1176	Extracellular (Potential).|III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						AGAGGACCCCGTCCTGACCAA	0.617000													47	66					0	0	1	0	0	
C1orf14	81626	broad.mit.edu	37	1	182922237	182922237	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:182922237G>A	uc001gpu.2	-	1	317	c.32C>T	c.(31-33)GCG>GTG	p.A11V	C1orf14_uc001gpv.2_5'UTR|C1orf14_uc010pnz.1_5'UTR|C1orf14_uc001gpw.2_5'UTR	NM_030933	NP_112195	Q9BZQ2	SHP1L_HUMAN	chromosome 1 open reading frame 14	83											0				Colorectal(1306;1.64e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00267)		GAATGAGTCCGCGGGCACCGA	0.716000													5	4					0	0	1	0	0	
FAM129A	116496	broad.mit.edu	37	1	184764591	184764591	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:184764591G>A	uc001gra.2	-	14	2501	c.2307C>T	c.(2305-2307)AGC>AGT	p.S769S	FAM129A_uc001grb.1_Intron	NM_052966	NP_443198	Q9BZQ8	NIBAN_HUMAN	niban protein isoform 2	769	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				ovary(3)|skin(1)	4						CCTCCCTCTCGCTGACTTCAC	0.607000													136	207					0	0	1	0	0	
CDC73	79577	broad.mit.edu	37	1	193104571	193104571	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:193104571C>T	uc001gtb.2	+	4	601	c.358C>T	c.(358-360)CGA>TGA	p.R120*	MIR1278_hsa-mir-1278|MI0006425_5'Flank	NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	120					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						AGGTCTTCAGCGATCTACTCA	0.333000									Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				19	37					0	0	1	0	0	
CACNA1S	779	broad.mit.edu	37	1	201042762	201042762	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:201042762G>A	uc001gvv.2	-	15	2299	c.2072C>T	c.(2071-2073)CCA>CTA	p.P691L		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	691	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TGACTTGTCTGGGAGACCCCT	0.537000													116	168					0	0	1	0	0	
CACNA1S	779	broad.mit.edu	37	1	201047120	201047120	+	Silent	SNP	G	A	A	rs141808465	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:201047120G>A	uc001gvv.2	-	11	1733	c.1506C>T	c.(1504-1506)TTC>TTT	p.F502F		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	502	Helical; Name=S3 of repeat II; (Potential).|II.				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TACACACCACGAAGCAGTCGA	0.592000													31	41					0	0	1	0	0	
CACNA1S	779	broad.mit.edu	37	1	201063104	201063104	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:201063104C>T	uc001gvv.2	-	3	531	c.304G>A	c.(304-306)GCC>ACC	p.A102T		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	102	I.|Helical; Name=S2 of repeat I; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	ATCTTCATGGCGGCTTCAATC	0.507000													24	37					0	0	1	0	0	
GPR37L1	9283	broad.mit.edu	37	1	202096944	202096944	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:202096944C>A	uc001gxj.2	+	2	769	c.706C>A	c.(706-708)CTG>ATG	p.L236M		NM_004767	NP_004758	O60883	ETBR2_HUMAN	G-protein coupled receptor 37 like 1 precursor	236	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|central_nervous_system(1)	2						CACCAGCACCCTGCCCAAGGT	0.627000													5	74					0.184627	0.185078	1	1	0	
PIK3C2B	5287	broad.mit.edu	37	1	204438269	204438269	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:204438269C>T	uc001haw.2	-	3	1141	c.662G>A	c.(661-663)CGC>CAC	p.R221H	PIK3C2B_uc010pqv.1_Missense_Mutation_p.R221H|PIK3C2B_uc001hax.1_Missense_Mutation_p.R221H|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	221	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CCCCAGTAGGCGCCCCTGACC	0.522000													162	281					0	0	1	0	0	
NFASC	23114	broad.mit.edu	37	1	204951100	204951100	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:204951100G>A	uc001hbj.2	+	21	2750	c.2422G>A	c.(2422-2424)GGG>AGG	p.G808R	NFASC_uc010pra.1_Missense_Mutation_p.G804R|NFASC_uc001hbi.2_Missense_Mutation_p.G804R|NFASC_uc010prb.1_Missense_Mutation_p.G819R|NFASC_uc010prc.1_Missense_Mutation_p.G375R|NFASC_uc001hbk.1_Missense_Mutation_p.G614R|NFASC_uc001hbl.1_Missense_Mutation_p.G58R	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	808	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAATGACTTCGGGAAGGGCCC	0.602000													6	20					0	0	1	0	0	
PIGR	5284	broad.mit.edu	37	1	207109149	207109149	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:207109149G>A	uc001hez.2	-	5	1244	c.1060C>T	c.(1060-1062)CGC>TGC	p.R354C	PIGR_uc009xbz.2_Missense_Mutation_p.R354C	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	354	Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GTGGGGCTGCGGGGAATCGTG	0.602000											OREG0014186	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	17					0	0	1	0	0	
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	T	T	rs55749440		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:207787753C>T	uc001hfy.2	+	32	5370	c.5230C>T	c.(5230-5232)CGA>TGA	p.R1744*	CR1_uc001hfx.2_Nonsense_Mutation_p.R2194*	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1744	Extracellular (Potential).|Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						CTTTAGGTTCCGATTAAAAGG	0.423000													6	46					0	0	1	0	0	
CAMK1G	57172	broad.mit.edu	37	1	209776581	209776581	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:209776581A>G	uc001hhd.2	+	4	346	c.244A>G	c.(244-246)ACC>GCC	p.T82A	CAMK1G_uc001hhf.3_Missense_Mutation_p.T82A|CAMK1G_uc001hhe.2_Missense_Mutation_p.T82A	NM_020439	NP_065172	Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	82	Protein kinase.					Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		AAACATTGTGACCCTGGAGGA	0.468000													18	32					0	0	1	0	0	
RCOR3	55758	broad.mit.edu	37	1	211486067	211486067	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:211486067C>T	uc001hig.2	+	10	1076	c.907C>T	c.(907-909)CGC>TGC	p.R303C	RCOR3_uc010psv.1_RNA|RCOR3_uc001hie.2_Missense_Mutation_p.R361C|RCOR3_uc010psw.1_Missense_Mutation_p.R361C|RCOR3_uc001hif.2_Intron|RCOR3_uc009xcz.2_RNA	NM_018254	NP_060724	Q9P2K3	RCOR3_HUMAN	REST corepressor 3 isoform d	303	SANT 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		TCCAGGTGTCCGCAAATATGG	0.393000													41	78					0	0	1	0	0	
FLVCR1	28982	broad.mit.edu	37	1	213032160	213032160	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:213032160C>T	uc001hjt.2	+	1	564	c.366C>T	c.(364-366)GCC>GCT	p.A122A	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	122	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		TGGTCAACGCCTTTCAGTGGA	0.612000													20	26					0	0	1	0	0	
EPRS	2058	broad.mit.edu	37	1	220195819	220195819	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:220195819C>T	uc001hly.1	-	9	1255	c.985G>A	c.(985-987)GGG>AGG	p.G329R	EPRS_uc010puf.1_Missense_Mutation_p.G80R|EPRS_uc001hlz.1_Missense_Mutation_p.G329R|EPRS_uc009xdt.1_Missense_Mutation_p.G130R	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	329	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AACTGGCTCCCTTTTTTCATT	0.348000													36	85					0	0	1	0	0	
IARS2	55699	broad.mit.edu	37	1	220313568	220313568	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:220313568G>C	uc001hmc.2	+	19	2455	c.2351G>C	c.(2350-2352)CGG>CCG	p.R784P	IARS2_uc001hmd.2_Missense_Mutation_p.R120P	NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	784					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	AAAGTTGTTCGGCTGTTACGG	0.308000													12	27					0	0	1	0	0	
DUSP10	11221	broad.mit.edu	37	1	221912920	221912920	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:221912920G>A	uc001hmy.1	-	2	349	c.167C>T	c.(166-168)GCG>GTG	p.A56V	DUSP10_uc001hmx.1_5'Flank|DUSP10_uc001hmz.1_Intron	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	56					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		CGTCAGATTCGCAGCCTTGAG	0.567000													20	62					0	0	1	0	0	
HHIPL2	79802	broad.mit.edu	37	1	222713534	222713534	+	Missense_Mutation	SNP	C	T	T	rs149049815	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:222713534C>T	uc001hnh.1	-	4	1326	c.1268G>A	c.(1267-1269)CGT>CAT	p.R423H		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	423					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		CACAGCACAACGCCACATGTT	0.597000													6	68					0	0	1	0	0	
MIA3	375056	broad.mit.edu	37	1	222794552	222794552	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:222794552G>A	uc001hnl.2	+	2	194	c.185G>A	c.(184-186)CGT>CAT	p.R62H		NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	62	SH3.|Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		CCGGATTGTCGTTTTGTGAAT	0.388000													21	44					0	0	1	0	0	
TLR5	7100	broad.mit.edu	37	1	223284234	223284234	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:223284234G>C	uc001hnv.1	-	4	2586	c.2140C>G	c.(2140-2142)CAC>GAC	p.H714D	TLR5_uc001hnw.1_Missense_Mutation_p.H714D	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	714	Cytoplasmic (Potential).|TIR.		Missing (in 10% of the population; abolishes flagellin signaling; associated with resistance to SLEB1).		cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		GTGTCCAGGTGTTTGAGCAAA	0.458000													19	34					0	0	1	0	0	
SRP9	6726	broad.mit.edu	37	1	225971006	225971006	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:225971006G>A	uc001hpg.2	+	2	205	c.77G>A	c.(76-78)CGT>CAT	p.R26H	SRP9_uc001hpf.3_RNA|SRP9_uc001hph.2_Missense_Mutation_p.R26H|SRP9_uc001hpi.3_RNA|SRP9_uc001hpj.1_Intron	NM_003133	NP_003124	P49458	SRP09_HUMAN	signal recognition particle 9kDa isoform 2	26					negative regulation of translational elongation|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle receptor complex|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding				0						TTTCAGGCACGTGTGGTTCTC	0.303000													32	27					0	0	1	0	0	
WNT3A	89780	broad.mit.edu	37	1	228210547	228210547	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:228210547G>A	uc001hrq.1	+	2	329	c.251G>A	c.(250-252)CGC>CAC	p.R84H	WNT3A_uc001hrp.1_Missense_Mutation_p.R84H	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	84					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				TTCCGCGGCCGCCGGTGGAAC	0.637000													19	36					0	0	1	0	0	
OBSCN	84033	broad.mit.edu	37	1	228481946	228481946	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:228481946C>T	uc009xez.1	+	42	11269	c.11225C>T	c.(11224-11226)CCG>CTG	p.P3742L	OBSCN_uc001hsn.2_Missense_Mutation_p.P3742L|OBSCN_uc001hsq.1_Missense_Mutation_p.P998L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3742	Ig-like 38.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AAGGCGGCACCGGTGGAGTGG	0.622000													62	89					0	0	1	0	0	
ACTA1	58	broad.mit.edu	37	1	229568141	229568141	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:229568141G>A	uc001htm.2	-	4	597	c.492C>T	c.(490-492)AAC>AAT	p.N164N		NM_001100	NP_001091	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	164					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton				0	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	AAATGGGCACGTTGTGGGTGA	0.667000													16	33					0	0	1	0	0	
NUP133	55746	broad.mit.edu	37	1	229599297	229599297	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:229599297G>C	uc001htn.2	-	19	2770	c.2678C>G	c.(2677-2679)GCT>GGT	p.A893G		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	893					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				CACCTGATCAGCAAACTGGGT	0.453000													18	41					0	0	1	0	0	
PGBD5	79605	broad.mit.edu	37	1	230486757	230486757	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:230486757G>A	uc010pwb.1	-	3	634	c.634C>T	c.(634-636)CGG>TGG	p.R212W	PGBD5_uc001htv.2_Missense_Mutation_p.R311W	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	212						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		CTGAATTTCCGCTTTTTCCTC	0.572000													28	60					0	0	1	0	0	
PCNXL2	80003	broad.mit.edu	37	1	233231580	233231580	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:233231580G>A	uc001hvl.2	-	22	4102	c.3867C>T	c.(3865-3867)TTC>TTT	p.F1289F	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_Intron|PCNXL2_uc001hvp.1_RNA|PCNXL2_uc009xfv.1_RNA	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1289						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				ATGTCAGGACGAACTGTAACT	0.443000													13	14					0	0	1	0	0	
TARBP1	6894	broad.mit.edu	37	1	234527354	234527354	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:234527354T>A	uc001hwd.2	-	30	4835	c.4835A>T	c.(4834-4836)CAG>CTG	p.Q1612L		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	1612					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			CGAGAGCAGCTGCTGCCTGGT	0.478000													19	20					0	0	1	0	0	
FH	2271	broad.mit.edu	37	1	241672068	241672068	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:241672068A>G	uc001hyx.2	-	5	605	c.573T>C	c.(571-573)TTT>TTC	p.F191F		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	191					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		TTGCTGTGGGAAAAGTATCAT	0.333000			Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				14	24					0	0	1	0	0	
ZNF496	84838	broad.mit.edu	37	1	247473056	247473056	+	Silent	SNP	G	A	A	rs112850226		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:247473056G>A	uc001ico.2	-	7	1302	c.837C>T	c.(835-837)CGC>CGT	p.R279R	ZNF496_uc009xgv.2_Silent_p.R315R|ZNF496_uc001icp.2_Silent_p.R279R|ZNF496_uc001icq.1_Silent_p.R54R	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	279	KRAB.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			ACTCTGGAACGCGTGGCTCAT	0.517000													22	27					0	0	1	0	0	
OR2T33	391195	broad.mit.edu	37	1	248436550	248436550	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:248436550G>T	uc010pzi.1	-	1	567	c.567C>A	c.(565-567)GAC>GAA	p.D189E		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGACTGAAGTGTCAGCACAAG	0.532000													11	54					9.16793e-09	9.48677e-09	1	1	0	
OR2T3	343173	broad.mit.edu	37	1	248636988	248636988	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:248636988G>C	uc001iel.1	+	1	337	c.337G>C	c.(337-339)GCT>CCT	p.A113P		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGACCCTGGCTGGAGCTGA	0.552000													28	45					0	0	1	0	0	
OR2T10	127069	broad.mit.edu	37	1	248756419	248756419	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:248756419A>G	uc010pzn.1	-	1	651	c.651T>C	c.(649-651)TCT>TCC	p.S217S		NM_001004693	NP_001004693	Q8NGZ9	O2T10_HUMAN	olfactory receptor, family 2, subfamily T,	217	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TATAGTAGTAAGACACTGAAA	0.453000													13	78					0	0	1	0	0	
DIP2C	22982	broad.mit.edu	37	10	372999	372999	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:372999G>A	uc001ifp.2	-	31	3961	c.3871C>T	c.(3871-3873)CGG>TGG	p.R1291W		NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	1291						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTGACGGCCCGCGGGTGAAGG	0.607000													21	32					0	0	1	0	0	
C10orf18	54906	broad.mit.edu	37	10	5762725	5762725	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:5762725C>T	uc001iij.2	+	5	659	c.34C>T	c.(34-36)CGC>TGC	p.R12C		NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	12										ovary(1)|central_nervous_system(1)	2						TAGACTTGAACGCAGTGAAAA	0.274000													10	15					0	0	1	0	0	
IL15RA	3601	broad.mit.edu	37	10	6008149	6008149	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:6008149G>A	uc001iiv.2	-	2	324	c.242C>T	c.(241-243)ACG>ATG	p.T81M	IL15RA_uc010qau.1_Missense_Mutation_p.T81M|IL15RA_uc001iiw.2_Missense_Mutation_p.T45M|IL15RA_uc001iix.2_Missense_Mutation_p.T45M|IL15RA_uc001iiy.2_Intron	NM_002189	NP_002180	Q13261	I15RA_HUMAN	interleukin 15 receptor, alpha isoform 1	81	Sushi.|Extracellular (Potential).				cell proliferation	cytoplasmic vesicle membrane|endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane|nuclear membrane	cytokine receptor activity				0						GGCGACATTCGTGGCCTTGTT	0.572000													19	18					0	0	1	0	0	
PRKCQ	5588	broad.mit.edu	37	10	6533724	6533724	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:6533724G>A	uc001ijj.1	-	8	786	c.711C>T	c.(709-711)TAC>TAT	p.Y237Y	PRKCQ_uc009xim.1_Silent_p.Y237Y|PRKCQ_uc001iji.1_Silent_p.Y270Y|PRKCQ_uc009xin.1_Silent_p.Y201Y|PRKCQ_uc010qax.1_Silent_p.Y112Y	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	237	Phorbol-ester/DAG-type 2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TCTTGTAATTGTAGACTTTAA	0.502000													37	75					0	0	1	0	0	
TAF3	83860	broad.mit.edu	37	10	8006080	8006080	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:8006080G>A	uc010qbd.1	+	3	607	c.607G>A	c.(607-609)GAC>AAC	p.D203N		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	203					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						CACTAAAGGGGACACGCTAGA	0.468000													44	49					0	0	1	0	0	
USP6NL	9712	broad.mit.edu	37	10	11504898	11504898	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:11504898C>T	uc001ikt.3	-	15	2350	c.2029G>A	c.(2029-2031)GTC>ATC	p.V677I	USP6NL_uc001iks.1_Missense_Mutation_p.V694I	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	677						intracellular	Rab GTPase activator activity				0						GAAGCACTGACGGAAAGAGTA	0.527000													8	20					0	0	1	0	0	
ECHDC3	79746	broad.mit.edu	37	10	11805348	11805348	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:11805348G>A	uc001ikw.3	+	5	937	c.717G>A	c.(715-717)AAG>AAA	p.K239K	ECHDC3_uc009xix.2_Silent_p.K108K	NM_024693	NP_078969	Q96DC8	ECHD3_HUMAN	enoyl Coenzyme A hydratase domain containing 3	239						mitochondrion	catalytic activity				0						TCGCTAGGAAGATCGCATCGC	0.642000													24	35					0	0	1	0	0	
SEPHS1	22929	broad.mit.edu	37	10	13364896	13364896	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:13364896C>T	uc001imk.2	-	8	1262	c.903G>A	c.(901-903)GCG>GCA	p.A301A	SEPHS1_uc001imh.2_Silent_p.A225A|SEPHS1_uc010qbs.1_Silent_p.A253A|SEPHS1_uc001imi.2_Silent_p.A299A|SEPHS1_uc001imj.2_Silent_p.A301A|SEPHS1_uc010qbt.1_Silent_p.A234A	NM_012247	NP_036379	P49903	SPS1_HUMAN	selenophosphate synthetase 1	301					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			skin(1)	1						CCTTGCTCACCGCAGCCATCT	0.582000													16	23					0	0	1	0	0	
C1QL3	389941	broad.mit.edu	37	10	16562696	16562696	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:16562696C>T	uc001ioj.1	-	1	1309	c.369G>A	c.(367-369)ACG>ACA	p.T123T		NM_001010908	NP_001010908	Q5VWW1	C1QL3_HUMAN	complement component 1, q subcomponent-like 3	123	C1q.					collagen				ovary(1)	1						TCTTGGGCACCGTGCTGTAGG	0.582000													25	46					0	0	1	0	0	
C10orf140	387640	broad.mit.edu	37	10	21804329	21804329	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:21804329C>T	uc009xkd.2	-	4	4676	c.2423G>A	c.(2422-2424)CGT>CAT	p.R808H	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	727						nucleus	nucleotide binding			ovary(1)	1						ACCTGTAGGACGAGGGCTTCT	0.438000													54	69					0	0	1	0	0	
MYO3A	53904	broad.mit.edu	37	10	26305796	26305796	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:26305796G>A	uc001isn.2	+	7	916	c.556G>A	c.(556-558)GTA>ATA	p.V186I	MYO3A_uc009xko.1_Missense_Mutation_p.V186I|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Missense_Mutation_p.V186I|MYO3A_uc001ism.2_Missense_Mutation_p.V186I	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	186	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GAACACATCCGTAGGAACACC	0.443000													23	52					0	0	1	0	0	
MYO3A	53904	broad.mit.edu	37	10	26446278	26446278	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:26446278C>T	uc001isn.2	+	26	3193	c.2833C>T	c.(2833-2835)CAA>TAA	p.Q945*	MYO3A_uc009xko.1_Nonsense_Mutation_p.Q945*|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	945	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GGTGGTGGGCCAACCTCATTT	0.383000													31	50					0	0	1	0	0	
GAD2	2572	broad.mit.edu	37	10	26570016	26570016	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:26570016G>T	uc001isp.2	+	12	1739	c.1236G>T	c.(1234-1236)GAG>GAT	p.E412D	GAD2_uc001isq.2_Missense_Mutation_p.E412D	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	412					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	TTAGAGAAGAGGTATGTCTCT	0.418000													26	43					2.48779e-11	2.61117e-11	1	1	0	
PTCHD3	374308	broad.mit.edu	37	10	27702415	27702415	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:27702415G>A	uc001itu.2	-	1	883	c.765C>T	c.(763-765)TGC>TGT	p.C255C		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	255					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						TGTACCTCGCGCACACCTGCT	0.622000													26	20					0	0	1	0	0	
KIAA1462	57608	broad.mit.edu	37	10	30315305	30315305	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:30315305G>A	uc001iux.2	-	2	3831	c.3772C>T	c.(3772-3774)CGC>TGC	p.R1258C	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.R1120C|KIAA1462_uc009xle.1_Missense_Mutation_p.R1258C	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	1258										ovary(4)	4						CTCATCAGGCGGTCAGGGTCT	0.532000													14	51					0	0	1	0	0	
ZNF438	220929	broad.mit.edu	37	10	31137669	31137669	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:31137669T>C	uc010qdz.1	-	7	2100	c.1665A>G	c.(1663-1665)AAA>AAG	p.K555K	ZNF438_uc001ivn.2_Silent_p.K506K|ZNF438_uc010qdy.1_Silent_p.K545K|ZNF438_uc001ivo.3_Silent_p.K119K|ZNF438_uc009xlg.2_Silent_p.K555K|ZNF438_uc001ivp.3_Silent_p.K545K|ZNF438_uc010qea.1_Silent_p.K555K|ZNF438_uc010qeb.1_Silent_p.K555K|ZNF438_uc010qec.1_Silent_p.K119K	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	555	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				CATGATGAAGTTTCATGTGTG	0.463000													84	134					0	0	1	0	0	
CCDC7	221016	broad.mit.edu	37	10	32740786	32740786	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:32740786T>C	uc001iwj.2	+	2	786	c.216T>C	c.(214-216)AGT>AGC	p.S72S	CCDC7_uc009xlu.1_RNA|CCDC7_uc001iwk.2_Silent_p.S72S|CCDC7_uc009xlv.2_RNA|CCDC7_uc009xlw.1_RNA|CCDC7_uc009xlx.1_Silent_p.S72S|CCDC7_uc009xly.1_RNA	NM_145023	NP_659460	Q96M83	CCDC7_HUMAN	coiled-coil domain containing 7	72											0		Breast(68;0.000207)|Prostate(175;0.0107)				TTCCATCGAGTAAGACAAAGA	0.323000													17	32					0	0	1	0	0	
FZD8	8325	broad.mit.edu	37	10	35929087	35929087	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:35929087G>A	uc001iyz.1	-	1	1276	c.1271C>T	c.(1270-1272)GCG>GTG	p.A424V		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	424	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						CATACCGGCCGCCAGGAACCA	0.632000													11	23					0	0	1	0	0	
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	Missense_Mutation	SNP	A	G	G	rs2257765		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:38654432A>G	uc010qex.1	+	5	599	c.524A>G	c.(523-525)AAT>AGT	p.N175S	HSD17B7P2_uc001izq.2_RNA|HSD17B7P2_uc001izo.1_RNA|HSD17B7P2_uc001izp.1_Missense_Mutation_p.N173S					SubName: Full=cDNA FLJ60462, highly similar to 3-keto-steroid reductase (EC 1.1.1.270);												0						TCATCTCGCAATGCAAGGAAA	0.453000													7	46					0	0	1	0	0	
PPYR1	5540	broad.mit.edu	37	10	47087071	47087071	+	Silent	SNP	G	A	A	rs143217098		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:47087071G>A	uc001jee.2	+	3	707	c.288G>A	c.(286-288)CCG>CCA	p.P96P	ANXA8_uc001jed.3_Intron|PPYR1_uc009xna.2_Silent_p.P96P	NM_005972	NP_005963	P50391	NPY4R_HUMAN	pancreatic polypeptide receptor 1	96	Helical; Name=2; (Potential).				blood circulation|digestion|feeding behavior	integral to plasma membrane				ovary(1)|skin(1)	2						TCTGCCAGCCGCTGACCGCCG	0.562000													23	155					0	0	1	0	0	
AGAP6	414189	broad.mit.edu	37	10	51754188	51754188	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:51754188A>G	uc001jix.3	+	4	793	c.395A>G	c.(394-396)CAT>CGT	p.H132R		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	132					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						TGTACAAACCATGTAAGTAAA	0.299000													9	89					0	0	1	0	0	
PRKG1	5592	broad.mit.edu	37	10	53667314	53667314	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:53667314C>T	uc001jjm.2	+	5	895	c.701C>T	c.(700-702)GCT>GTT	p.A234V	PRKG1_uc001jjn.2_Missense_Mutation_p.A249V|PRKG1_uc001jjo.2_Missense_Mutation_p.A249V	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	234	cGMP 2.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		AGCAAGCTTGCTGATGTCCTT	0.433000													41	71					0	0	1	0	0	
PCDH15	65217	broad.mit.edu	37	10	56077099	56077099	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:56077099G>A	uc001jju.1	-	8	1203	c.808C>T	c.(808-810)CTT>TTT	p.L270F	PCDH15_uc010qhq.1_Missense_Mutation_p.L275F|PCDH15_uc010qhr.1_Missense_Mutation_p.L270F|PCDH15_uc010qhs.1_Missense_Mutation_p.L275F|PCDH15_uc010qht.1_Missense_Mutation_p.L270F|PCDH15_uc010qhu.1_Missense_Mutation_p.L270F|PCDH15_uc001jjv.1_Missense_Mutation_p.L248F|PCDH15_uc010qhv.1_Missense_Mutation_p.L270F|PCDH15_uc010qhw.1_Missense_Mutation_p.L233F|PCDH15_uc010qhx.1_Missense_Mutation_p.L270F|PCDH15_uc010qhy.1_Missense_Mutation_p.L275F|PCDH15_uc010qhz.1_Missense_Mutation_p.L270F|PCDH15_uc010qia.1_Missense_Mutation_p.L248F|PCDH15_uc010qib.1_Missense_Mutation_p.L248F|PCDH15_uc001jjw.2_Missense_Mutation_p.L270F	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	270	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTTGGCACAAGGACACAAGGA	0.463000										HNSCC(58;0.16)			40	68					0	0	1	0	0	
RTKN2	219790	broad.mit.edu	37	10	63959571	63959571	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:63959571T>C	uc001jlw.2	-	11	1333	c.1236A>G	c.(1234-1236)TCA>TCG	p.S412S	RTKN2_uc009xpf.1_Silent_p.S214S|RTKN2_uc001jlv.2_Silent_p.S66S	NM_145307	NP_660350	Q8IZC4	RTKN2_HUMAN	rhotekin 2	412					signal transduction	intracellular					0	Prostate(12;0.0297)|all_hematologic(501;0.215)					GTTTCCGTGGTGACATAATCT	0.373000													21	55					0	0	1	0	0	
JMJD1C	221037	broad.mit.edu	37	10	64967560	64967560	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:64967560T>C	uc001jmn.2	-	10	4169	c.3869A>G	c.(3868-3870)CAT>CGT	p.H1290R	JMJD1C_uc001jml.2_Missense_Mutation_p.H1071R|JMJD1C_uc001jmm.2_Missense_Mutation_p.H1002R|JMJD1C_uc010qiq.1_Missense_Mutation_p.H1108R|JMJD1C_uc009xpi.2_Missense_Mutation_p.H1108R|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.H327R	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1290					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTTCTCCACATGCCATTCAGT	0.423000													43	93					0	0	1	0	0	
H2AFY2	55506	broad.mit.edu	37	10	71835526	71835526	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:71835526A>G	uc001jqm.2	+	2	571	c.112A>G	c.(112-114)AAG>GAG	p.K38E	H2AFY2_uc001jqn.2_RNA	NM_018649	NP_061119	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	38	Histone H2A.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			skin(1)	1						AGGGACGTTCAAGTACCGGAT	0.562000													17	30					0	0	1	0	0	
ADAMTS14	140766	broad.mit.edu	37	10	72495033	72495033	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:72495033C>T	uc001jrh.2	+	9	1461	c.1461C>T	c.(1459-1461)GGC>GGT	p.G487G	ADAMTS14_uc001jrg.2_Silent_p.G490G|ADAMTS14_uc001jri.1_Silent_p.G10G	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	487	Disintegrin.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						TTGACTTTGGCAGTGGCTACC	0.597000													15	27					0	0	1	0	0	
UNC5B	219699	broad.mit.edu	37	10	73058904	73058904	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:73058904C>T	uc001jro.2	+	17	3153	c.2708C>T	c.(2707-2709)ACG>ATG	p.T903M	UNC5B_uc001jrp.2_Missense_Mutation_p.T892M|UNC5B_uc001jrq.1_5'Flank	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	903	Cytoplasmic (Potential).|Death.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GCGAGCCCCACGGGTGTGATC	0.612000													81	131					0	0	1	0	0	
PSAP	5660	broad.mit.edu	37	10	73594249	73594249	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:73594249C>T	uc001jsm.2	-	2	158	c.54G>A	c.(52-54)CCG>CCA	p.P18P		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	18	Saposin A-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						GTCCAAGGACCGGGCCGGCTA	0.587000													4	20					0	0	1	0	0	
PPP3CB	5532	broad.mit.edu	37	10	75238307	75238307	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:75238307G>A	uc001jue.2	-	3	496	c.361C>T	c.(361-363)CGA>TGA	p.R121*	PPP3CB_uc001juf.2_Nonsense_Mutation_p.R121*|PPP3CB_uc001jug.2_Nonsense_Mutation_p.R121*|PPP3CB_uc001jui.2_Nonsense_Mutation_p.R121*|PPP3CB_uc001juh.2_Nonsense_Mutation_p.R35*	NM_021132	NP_066955	P16298	PP2BB_HUMAN	protein phosphatase 3, catalytic subunit, beta	121	Catalytic.									skin(1)	1	Prostate(51;0.0119)					AAAAGGTATCGTGTATTAGCA	0.343000													32	39					0	0	1	0	0	
AGAP5	729092	broad.mit.edu	37	10	75451802	75451802	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:75451802T>C	uc009xri.2	-	4	436	c.395A>G	c.(394-396)CAT>CGT	p.H132R	AGAP5_uc001juu.3_Missense_Mutation_p.H93R	NM_001144000	NP_001137472	A6NIR3	AGAP5_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	132					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						TTTACTTACATGGTTTGTACA	0.299000													6	118					0	0	1	0	0	
MYST4	23522	broad.mit.edu	37	10	76789460	76789460	+	Silent	SNP	C	T	T	rs146568876		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:76789460C>T	uc001jwn.1	+	18	5371	c.4878C>T	c.(4876-4878)TAC>TAT	p.Y1626Y	MYST4_uc001jwo.1_Silent_p.Y1334Y|MYST4_uc001jwp.1_Silent_p.Y1443Y	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1626	Ser-rich.|Interaction with RUNX1 and RUNX2.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					AAAACAGCTACGCCCAAATCA	0.527000			T	CREBBP	AML								53	55					0	0	1	0	0	
ZNF503	84858	broad.mit.edu	37	10	77158594	77158594	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:77158594C>T	uc001jxg.2	-	2	2190	c.1854G>A	c.(1852-1854)CCG>CCA	p.P618P	C10orf41_uc010qlf.1_5'Flank	NM_032772	NP_116161	Q96F45	ZN503_HUMAN	zinc finger protein 503	618					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1	all_cancers(46;0.105)|all_epithelial(25;0.00449)|Prostate(51;0.0112)|Ovarian(15;0.088)					CGGCGGGCACCGGCACGGGGG	0.662000													5	8					0	0	1	0	0	
KCNMA1	3778	broad.mit.edu	37	10	78651292	78651292	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:78651292C>T	uc001jxn.2	-	26	3510	c.3333G>A	c.(3331-3333)GCG>GCA	p.A1111A	KCNMA1_uc001jxj.2_Silent_p.A1057A|KCNMA1_uc001jxk.1_Silent_p.A729A|KCNMA1_uc009xrt.1_Silent_p.A902A|KCNMA1_uc001jxl.1_Silent_p.A736A|KCNMA1_uc001jxo.2_Silent_p.A1094A|KCNMA1_uc001jxm.2_Silent_p.A1053A|KCNMA1_uc001jxq.2_Silent_p.A1083A|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1111	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CCCCTAAGTCCGCAAATGGCC	0.567000													16	20					0	0	1	0	0	
DLG5	9231	broad.mit.edu	37	10	79553804	79553804	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:79553804G>A	uc001jzk.2	-	31	5688	c.5618C>T	c.(5617-5619)GCG>GTG	p.A1873V	DLG5_uc001jzi.2_Missense_Mutation_p.A628V|DLG5_uc001jzj.2_Missense_Mutation_p.A1288V	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1873	Guanylate kinase-like.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AAGCTTCTGCGCCGCCTCAAA	0.592000													10	143					0	0	1	0	0	
ZMIZ1	57178	broad.mit.edu	37	10	81053363	81053363	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:81053363C>G	uc001kaf.2	+	12	1755	c.1183C>G	c.(1183-1185)CCC>GCC	p.P395A	ZMIZ1_uc001kag.2_Missense_Mutation_p.P271A|ZMIZ1_uc001kah.1_Missense_Mutation_p.P277A	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	395	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			GGGCCCCCGGCCCCAGTCCCT	0.667000													48	69					0	0	1	0	0	
SFTPD	6441	broad.mit.edu	37	10	81701716	81701716	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:81701716C>T	uc001kbh.2	-	5	587	c.544G>A	c.(544-546)GCA>ACA	p.A182T	MBL1P_uc001kbf.2_Intron	NM_003019	NP_003010	P35247	SFTPD_HUMAN	pulmonary surfactant-associated protein D	182	Collagen-like.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			skin(1)	1	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			TCACCTGCTGCCCCTGTGTTT	0.647000													39	60					0	0	1	0	0	
FAM190B	54462	broad.mit.edu	37	10	86132007	86132007	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:86132007C>T	uc001kdh.1	+	2	1393	c.1199C>T	c.(1198-1200)TCG>TTG	p.S400L	FAM190B_uc001kdg.1_Missense_Mutation_p.S400L|FAM190B_uc010qmd.1_Missense_Mutation_p.S400L	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	400										ovary(3)|skin(1)	4						ATTTCCTTGTCGTCTTTGTCA	0.333000													22	32					0	0	1	0	0	
BMPR1A	657	broad.mit.edu	37	10	88676973	88676973	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:88676973G>A	uc001kdy.2	+	9	1306	c.758G>A	c.(757-759)TGG>TAG	p.W253*		NM_004329	NP_004320	P36894	BMR1A_HUMAN	bone morphogenetic protein receptor, type IA	253	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|immune response|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	integral to membrane|plasma membrane	ATP binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta receptor activity			lung(3)|large_intestine(1)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	8						ATGGGCAAATGGCGTGGCGAA	0.438000			Mis|N|F			gastrointestinal polyps			Hereditary_Mixed_Polyposis_syndrome_type_2|Juvenile_Polyposis				28	28					0	0	1	0	0	
AGAP11	119385	broad.mit.edu	37	10	88768527	88768527	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:88768527G>A	uc001kee.2	+	12	1722	c.518G>A	c.(517-519)CGG>CAG	p.R173Q	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	173	PH.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						ATTGACCTTCGGACATCTACC	0.443000													42	123					0	0	1	0	0	
CYP26A1	1592	broad.mit.edu	37	10	94834693	94834693	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:94834693G>A	uc001kil.2	+	3	617	c.572G>A	c.(571-573)CGC>CAC	p.R191H	CYP26A1_uc001kik.1_Missense_Mutation_p.R122H|CYP26A1_uc001kim.1_Missense_Mutation_p.R89H	NM_000783	NP_000774	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A,	191					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		Colorectal(252;0.122)				ATCGCCATGCGCATCCTACTG	0.652000													30	41					0	0	1	0	0	
GPR120	338557	broad.mit.edu	37	10	95326941	95326941	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:95326941G>A	uc010qnt.1	+	1	520	c.464G>A	c.(463-465)CGG>CAG	p.R155Q	GPR120_uc010qnu.1_Missense_Mutation_p.R155Q	NM_181745	NP_859529	Q5NUL3	O3FA1_HUMAN	G protein-coupled receptor 120	155	Cytoplasmic (Potential).				negative regulation of cytokine secretion|negative regulation of inflammatory response|regulation of glucose transport	integral to membrane|plasma membrane	fatty acid binding				0		Colorectal(252;0.122)				CGGCGGGCGCGGGCAGTGCTG	0.726000													14	14					0	0	1	0	0	
SORBS1	10580	broad.mit.edu	37	10	97117446	97117446	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:97117446G>A	uc001kkp.2	-	21	2115	c.2070C>T	c.(2068-2070)GAC>GAT	p.D690D	SORBS1_uc001kkk.2_Silent_p.D184D|SORBS1_uc001kkl.2_Silent_p.D292D|SORBS1_uc001kkn.2_Silent_p.D455D|SORBS1_uc001kkm.2_Silent_p.D490D|SORBS1_uc001kko.2_Silent_p.D712D|SORBS1_uc001kkq.2_Silent_p.D541D|SORBS1_uc001kkr.2_Silent_p.D396D|SORBS1_uc001kks.2_Silent_p.D396D|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Silent_p.D437D|SORBS1_uc001kkv.2_Silent_p.D528D|SORBS1_uc001kkw.2_Silent_p.D644D|SORBS1_uc010qoe.1_Silent_p.D405D|SORBS1_uc010qof.1_Silent_p.D758D	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	690				D -> V (in Ref. 1; AAD27647 and 3; AAF22175).	focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GAAGAGGGATGTCACCACCTT	0.517000													24	49					0	0	1	0	0	
ALDH18A1	5832	broad.mit.edu	37	10	97371130	97371130	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:97371130G>A	uc001kkz.2	-	16	2235	c.1993C>T	c.(1993-1995)CGA>TGA	p.R665*	ALDH18A1_uc001kky.2_Nonsense_Mutation_p.R663*|ALDH18A1_uc010qog.1_Nonsense_Mutation_p.R554*|ALDH18A1_uc010qoh.1_Nonsense_Mutation_p.R453*	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	665	Gamma-glutamyl phosphate reductase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	TACTCAGTTCGGAGTGACTTC	0.502000													97	133					0	0	1	0	0	
PIK3AP1	118788	broad.mit.edu	37	10	98469322	98469322	+	Splice_Site	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:98469322A>G	uc001kmq.2	-	2	558	c.430_splice	c.e2+1	p.D144_splice		NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1							cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		AGAAATCCTTACCTTCGGAAA	0.453000													6	110					0	0	1	0	0	
RRP12	23223	broad.mit.edu	37	10	99139503	99139503	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:99139503G>A	uc001knf.2	-	14	1697	c.1558C>T	c.(1558-1560)CGC>TGC	p.R520C	RRP12_uc009xvm.2_Missense_Mutation_p.R238C|RRP12_uc010qou.1_Missense_Mutation_p.R459C|RRP12_uc009xvn.2_Missense_Mutation_p.R420C	NM_015179	NP_055994	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog isoform 1	520						integral to membrane|nuclear membrane|nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GGGGAGAGGCGCAGGTCACAC	0.607000													17	25					0	0	1	0	0	
SFRP5	6425	broad.mit.edu	37	10	99531377	99531377	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:99531377G>A	uc001kor.3	-	1	380	c.214C>T	c.(214-216)CGG>TGG	p.R72W		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	72	FZ.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		TTGGGCAGCCGCATGCGCTTG	0.692000													15	23					0	0	1	0	0	
CRTAC1	55118	broad.mit.edu	37	10	99625397	99625397	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:99625397C>T	uc001kou.1	-	15	2250	c.1894G>A	c.(1894-1896)GCT>ACT	p.A632T	GOLGA7B_uc001kos.2_Silent_p.S148S|CRTAC1_uc001kot.1_Silent_p.P407P	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	632	Ala-rich.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		gctccagcagcggcagcagca	0.488000													10	11					0	0	1	0	0	
CNNM1	26507	broad.mit.edu	37	10	101120624	101120624	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:101120624C>T	uc001kpp.3	+	3	2039	c.1750C>T	c.(1750-1752)CGG>TGG	p.R584W	CNNM1_uc009xwe.2_Missense_Mutation_p.R584W|CNNM1_uc010qpi.1_Missense_Mutation_p.R584W|CNNM1_uc009xwf.2_Missense_Mutation_p.R584W|CNNM1_uc009xwg.2_Translation_Start_Site	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	584					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		GGTCCCGCAACGGGAGCGGAA	0.522000													48	122					0	0	1	0	0	
NKX2-3	159296	broad.mit.edu	37	10	101295035	101295035	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:101295035G>A	uc009xwj.2	+	2	851	c.652G>A	c.(652-654)GCG>ACG	p.A218T		NM_145285	NP_660328	Q8TAU0	NKX23_HUMAN	NK2 transcription factor related, locus 3	218						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.45e-08)		TGGCGCACAcgcgcccccgcc	0.547000													8	11					0	0	1	0	0	
ENTPD7	57089	broad.mit.edu	37	10	101464363	101464363	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:101464363A>G	uc001kqa.3	+	13	1916	c.1738A>G	c.(1738-1740)ACA>GCA	p.T580A	ENTPD7_uc009xwl.2_Missense_Mutation_p.T582A	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	580	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		CCACCGACAAACACGAGCCTC	0.542000													14	30					0	0	1	0	0	
FGF8	2253	broad.mit.edu	37	10	103531218	103531218	+	Splice_Site	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:103531218A>G	uc001ktp.1	-	5	581	c.411_splice	c.e5+1	p.K137_splice	FGF8_uc001ktq.1_Splice_Site_p.K148_splice|FGF8_uc001ktr.1_Splice_Site_p.K119_splice|FGF8_uc001kts.1_Splice_Site_p.K108_splice|FGF8_uc009xwr.1_Splice_Site_p.K44_splice	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor						bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		CTGGGGCCTCACCTTGGCGAT	0.612000													20	38					0	0	1	0	0	
PITX3	5309	broad.mit.edu	37	10	103991469	103991469	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:103991469C>T	uc001kuu.1	-	3	351	c.197G>A	c.(196-198)CGC>CAC	p.R66H		NM_005029	NP_005020	O75364	PITX3_HUMAN	paired-like homeodomain 3	66	Homeobox.				dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GAAGTGCGTGCGCTGCCGCCG	0.667000													9	9					0	0	1	0	0	
GBF1	8729	broad.mit.edu	37	10	104128195	104128195	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:104128195G>A	uc001kux.1	+	22	3100	c.2860G>A	c.(2860-2862)GCC>ACC	p.A954T	GBF1_uc001kuy.1_Missense_Mutation_p.A954T|GBF1_uc001kuz.1_Missense_Mutation_p.A955T	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	954					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CATCCAGAAAGCCATCTCAGG	0.502000													24	41					0	0	1	0	0	
CNNM2	54805	broad.mit.edu	37	10	104836892	104836892	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:104836892G>A	uc001kwm.2	+	8	2707	c.2583G>A	c.(2581-2583)ACG>ACA	p.T861T	CNNM2_uc001kwn.2_Silent_p.T839T	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	861					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		ACTGTGTGACGCACAGTAAGG	0.612000													16	44					0	0	1	0	0	
PDCD11	22984	broad.mit.edu	37	10	105162907	105162907	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:105162907C>T	uc001kwy.1	+	4	354	c.267C>T	c.(265-267)TGC>TGT	p.C89C		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	89	S1 motif 1.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTTTGGGTTGCGTGAAAGAGG	0.458000													65	109					0	0	1	0	0	
PDCD11	22984	broad.mit.edu	37	10	105185248	105185248	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:105185248C>T	uc001kwy.1	+	20	3358	c.3271C>T	c.(3271-3273)CGA>TGA	p.R1091*		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1091	S1 motif 9.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GGTCACTGCCCGAGTGATTGG	0.537000													18	41					0	0	1	0	0	
PDCD11	22984	broad.mit.edu	37	10	105200090	105200090	+	Missense_Mutation	SNP	G	A	A	rs141994658		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:105200090G>A	uc001kwy.1	+	29	4279	c.4192G>A	c.(4192-4194)GGA>AGA	p.G1398R		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1398					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTTCCTCCCCGGAGACACTGG	0.393000													48	94					0	0	1	0	0	
SH3PXD2A	9644	broad.mit.edu	37	10	105372688	105372688	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:105372688C>T	uc001kxj.1	-	11	1236	c.1096G>A	c.(1096-1098)GTT>ATT	p.V366I	SH3PXD2A_uc010qqr.1_Missense_Mutation_p.V256I|SH3PXD2A_uc010qqs.1_Missense_Mutation_p.V201I|SH3PXD2A_uc010qqt.1_Missense_Mutation_p.V243I|SH3PXD2A_uc009xxn.1_Missense_Mutation_p.V201I|SH3PXD2A_uc010qqu.1_Missense_Mutation_p.V309I	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	394					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CTGTCAGGAACGCCCACGGCA	0.632000													16	27					0	0	1	0	0	
TCF7L2	6934	broad.mit.edu	37	10	114912186	114912186	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:114912186C>T	uc001lae.3	+	11	1763	c.1256C>T	c.(1255-1257)GCG>GTG	p.A419V	TCF7L2_uc001lac.3_Missense_Mutation_p.A396V|TCF7L2_uc010qrk.1_Missense_Mutation_p.A396V|TCF7L2_uc010qrl.1_Missense_Mutation_p.A396V|TCF7L2_uc010qrm.1_Missense_Mutation_p.A419V|TCF7L2_uc010qrn.1_Missense_Mutation_p.A362V|TCF7L2_uc001lad.3_Missense_Mutation_p.A392V|TCF7L2_uc001lag.3_Missense_Mutation_p.A443V|TCF7L2_uc001laf.3_Missense_Mutation_p.A396V|TCF7L2_uc010qro.1_Missense_Mutation_p.A396V|TCF7L2_uc001lah.2_Missense_Mutation_p.A401V|TCF7L2_uc010qrp.1_Missense_Mutation_p.A396V|TCF7L2_uc010qrq.1_Missense_Mutation_p.A392V|TCF7L2_uc010qrr.1_Missense_Mutation_p.A334V|TCF7L2_uc010qrs.1_Missense_Mutation_p.A290V|TCF7L2_uc010qrt.1_Missense_Mutation_p.A290V|TCF7L2_uc010qru.1_Missense_Mutation_p.A318V|TCF7L2_uc010qrv.1_Missense_Mutation_p.A236V|TCF7L2_uc010qrw.1_Missense_Mutation_p.A123V|TCF7L2_uc010qrx.1_Missense_Mutation_p.A276V	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	419					anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		GGCTGGTCCGCGCGGGATAAC	0.527000													56	102					0	0	1	0	0	
AFAP1L2	84632	broad.mit.edu	37	10	116082999	116082999	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:116082999C>G	uc001lbn.2	-	5	638	c.337G>C	c.(337-339)GCC>CCC	p.A113P	AFAP1L2_uc001lbo.2_Missense_Mutation_p.A113P|AFAP1L2_uc010qse.1_Missense_Mutation_p.A166P|AFAP1L2_uc001lbp.2_Missense_Mutation_p.A113P|AFAP1L2_uc001lbr.1_Missense_Mutation_p.A113P	NM_001001936	NP_001001936	Q8N4X5	AF1L2_HUMAN	KIAA1914 protein isoform 1	113					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			ovary(1)|breast(1)	2		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		TTTGGGATGGCAAGCTGTTTC	0.498000													4	5					0	0	1	0	0	
VAX1	11023	broad.mit.edu	37	10	118896129	118896129	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:118896129G>T	uc009xyx.2	-	2	528	c.283C>A	c.(283-285)CTG>ATG	p.L95M	VAX1_uc001ldb.1_Missense_Mutation_p.L95M	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	95						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		TCCAAGTCCAGGCCCTTGGGC	0.657000													6	50					0.0215528	0.0216901	1	1	0	
INPP5F	22876	broad.mit.edu	37	10	121582587	121582587	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:121582587T>C	uc001leo.2	+	18	2203	c.2037T>C	c.(2035-2037)CCT>CCC	p.P679P	INPP5F_uc001lep.2_Silent_p.P69P	NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	679							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		TTTTAGGCCCTGAACCCACTC	0.368000													28	58					0	0	1	0	0	
WDR11	55717	broad.mit.edu	37	10	122645359	122645359	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:122645359A>G	uc010qtf.1	+	15	2120	c.1882A>G	c.(1882-1884)AGA>GGA	p.R628G	WDR11_uc010qte.1_Missense_Mutation_p.R230G|WDR11_uc001lfd.1_Missense_Mutation_p.R146G|WDR11_uc009xzn.2_5'Flank	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	628						integral to membrane					0						GAAGAGCCTGAGAAAGAAGCA	0.473000													36	58					0	0	1	0	0	
TACC2	10579	broad.mit.edu	37	10	123970335	123970335	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:123970335C>T	uc001lfv.2	+	9	6755	c.6395C>T	c.(6394-6396)CCG>CTG	p.P2132L	TACC2_uc001lfw.2_Missense_Mutation_p.P278L|TACC2_uc009xzx.2_Missense_Mutation_p.P2087L|TACC2_uc010qtv.1_Missense_Mutation_p.P2136L|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.P210L|TACC2_uc001lga.2_Missense_Mutation_p.P210L|TACC2_uc009xzy.2_Missense_Mutation_p.P210L|TACC2_uc001lgb.2_Missense_Mutation_p.P167L|TACC2_uc010qtw.1_Missense_Mutation_p.P227L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2132						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AAACCGAGGCCGCCTTCCTTA	0.547000													7	175					0	0	1	0	0	
CTBP2	1488	broad.mit.edu	37	10	126727587	126727587	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:126727587G>A	uc009yak.2	-	3	324	c.37C>T	c.(37-39)CGA>TGA	p.R13*	CTBP2_uc009yal.2_Nonsense_Mutation_p.R13*|CTBP2_uc001lif.3_Nonsense_Mutation_p.R13*|CTBP2_uc001lih.3_Nonsense_Mutation_p.R13*	NM_001329	NP_001320	P56545	CTBP2_HUMAN	C-terminal binding protein 2 isoform 1	13					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding				0		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CTGTCCAATCGCTGTCTCTTG	0.453000													35	58					0	0	1	0	0	
C10orf137	26098	broad.mit.edu	37	10	127438079	127438079	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:127438079C>T	uc001liq.1	+	22	3515	c.3222C>T	c.(3220-3222)TGC>TGT	p.C1074C	C10orf137_uc001lio.1_Silent_p.C1040C|C10orf137_uc001lip.1_Silent_p.C778C|C10orf137_uc001lis.1_Silent_p.C400C|C10orf137_uc001lit.1_5'UTR	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	1074					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				ATGCTCCCTGCGAACTGCTTA	0.443000													26	52					0	0	1	0	0	
DOCK1	1793	broad.mit.edu	37	10	128851058	128851058	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:128851058G>A	uc001ljt.2	+	22	2316	c.2252G>A	c.(2251-2253)CGC>CAC	p.R751H	DOCK1_uc010qun.1_Missense_Mutation_p.R772H	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	751					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TTCATCGTGCGCTCCAGGATC	0.458000													8	12					0	0	1	0	0	
MKI67	4288	broad.mit.edu	37	10	129902379	129902379	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:129902379T>C	uc001lke.2	-	13	7920	c.7725A>G	c.(7723-7725)TCA>TCG	p.S2575S	MKI67_uc001lkf.2_Silent_p.S2215S|MKI67_uc009yav.1_Silent_p.S2150S|MKI67_uc009yaw.1_Silent_p.S1725S	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2575	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CAATAGTCATTGACTCTTCAG	0.498000													58	75					0	0	1	0	0	
EBF3	253738	broad.mit.edu	37	10	131641447	131641447	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:131641447G>A	uc001lki.1	-	12	1180	c.1121C>T	c.(1120-1122)GCG>GTG	p.A374V		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	383					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CAGGTCCGCCGCCCGCTTCAG	0.602000													4	18					0	0	1	0	0	
GPR123	84435	broad.mit.edu	37	10	134942560	134942560	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:134942560G>A	uc001llx.3	+	7	1664	c.1228G>A	c.(1228-1230)GAC>AAC	p.D410N	GPR123_uc001llw.2_Missense_Mutation_p.D1129N	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	410	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CTTCGGGCACGACCCCCACCT	0.682000													3	1					0	0	1	0	0	
B4GALNT4	338707	broad.mit.edu	37	11	375731	375731	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:375731G>A	uc001lpb.2	+	10	952	c.943G>A	c.(943-945)GCA>ACA	p.A315T		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	315	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGAGACCAGCGCAGACATGCT	0.562000													4	43					0	0	1	0	0	
MUC6	4588	broad.mit.edu	37	11	1013590	1013590	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:1013590A>G	uc001lsw.2	-	33	7237	c.7186T>C	c.(7186-7188)TGC>CGC	p.C2396R		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	2396	CTCK.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGGGGGCGGCAGCAGCTGCAG	0.647000													3	2					0	0	1	0	0	
MUC2	4583	broad.mit.edu	37	11	1084335	1084335	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:1084335G>A	uc001lsx.1	+	19	2494	c.2467G>A	c.(2467-2469)GTC>ATC	p.V823I		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	823						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ATGCCCTTGCGTCCATAACAA	0.622000													13	19					0	0	1	0	0	
MUC2	4583	broad.mit.edu	37	11	1096474	1096474	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:1096474C>A	uc001lsx.1	+	37	13612	c.13585C>A	c.(13585-13587)CCC>ACC	p.P4529T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4529	VWFD 4.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCACTGCGATCCCAACGACAA	0.582000													27	44					4.22769e-11	4.43055e-11	1	1	0	
MUC5B	727897	broad.mit.edu	37	11	1278846	1278846	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:1278846C>T	uc009ycr.1	+	63	17493	c.17367C>T	c.(17365-17367)GAC>GAT	p.D5789D	MUC5B_uc001ltb.2_Silent_p.D5455D	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5452	VWFC 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TGCCCTGTGACGCCCAGGGTC	0.677000													10	12					0	0	1	0	0	
OSBPL5	114879	broad.mit.edu	37	11	3125509	3125509	+	Silent	SNP	G	A	A	rs138582624	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:3125509G>A	uc001lxk.2	-	10	1316	c.1158C>T	c.(1156-1158)CGC>CGT	p.R386R	OSBPL5_uc010qxq.1_Silent_p.R297R|OSBPL5_uc009ydw.2_Silent_p.R318R|OSBPL5_uc001lxl.2_Silent_p.R318R|OSBPL5_uc009ydx.2_Silent_p.R410R	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	386					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GTAGCACCACGCGGGACAGGT	0.622000													24	33					0	0	1	0	0	
RRM1	6240	broad.mit.edu	37	11	4148290	4148290	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:4148290G>A	uc001lyw.3	+	14	1815	c.1496G>A	c.(1495-1497)CGC>CAC	p.R499H	RRM1_uc009yej.2_RNA|RRM1_uc009yei.2_Missense_Mutation_p.R459H|RRM1_uc010qyc.1_Missense_Mutation_p.R402H|RRM1_uc010qyd.1_Missense_Mutation_p.R161H	NM_001033	NP_001024	P23921	RIR1_HUMAN	ribonucleoside-diphosphate reductase M1 chain	499					deoxyribonucleotide biosynthetic process|DNA replication|nucleobase, nucleoside and nucleotide interconversion	cytosol|nucleoplasm|ribonucleoside-diphosphate reductase complex	ATP binding|ribonucleoside-diphosphate reductase activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.00502)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0848)|LUSC - Lung squamous cell carcinoma(625;0.205)	Clofarabine(DB00631)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Hydroxyurea(DB01005)	AAACGCCATCGCCCCATTGGA	0.408000													36	77					0	0	1	0	0	
OR52H1	390067	broad.mit.edu	37	11	5566416	5566416	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:5566416T>C	uc010qzh.1	-	1	338	c.338A>G	c.(337-339)CAC>CGC	p.H113R	HBG2_uc001mak.1_Intron	NM_001005289	NP_001005289	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H,	113	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGTTATAGTGAAGGAAGAA	0.458000													24	58					0	0	1	0	0	
OR52E4	390081	broad.mit.edu	37	11	5905781	5905781	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:5905781T>C	uc010qzs.1	+	1	259	c.259T>C	c.(259-261)TTC>CTC	p.F87L	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTAGGAATCTTCTGGTTCAA	0.453000													59	76					0	0	1	0	0	
CNGA4	1262	broad.mit.edu	37	11	6261451	6261451	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:6261451C>T	uc001mco.2	+	4	534	c.427C>T	c.(427-429)CGC>TGC	p.R143C	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.R103C	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	143	Extracellular (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGGCTGAACCGCTTTCTCCG	0.607000													61	111					0	0	1	0	0	
DNHD1	144132	broad.mit.edu	37	11	6592278	6592278	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:6592278C>T	uc001mdw.3	+	42	14100	c.13536C>T	c.(13534-13536)GGC>GGT	p.G4512G	DNHD1_uc001mea.3_Silent_p.G781G|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Silent_p.G780G|DNHD1_uc010rao.1_Silent_p.G770G|DNHD1_uc009yfg.2_Silent_p.G137G	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4512					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		AGCTGAAGGGCGCACCCCCGT	0.682000													10	32					0	0	1	0	0	
DCHS1	8642	broad.mit.edu	37	11	6653519	6653519	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:6653519A>G	uc001mem.1	-	6	3634	c.3224T>C	c.(3223-3225)GTG>GCG	p.V1075A		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1075	Cadherin 10.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGACCCAGACACTGCCATTAC	0.577000													34	46					0	0	1	0	0	
SYT9	143425	broad.mit.edu	37	11	7334764	7334764	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:7334764C>T	uc001mfe.2	+	3	873	c.636C>T	c.(634-636)GAC>GAT	p.D212D	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_Intron	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	212	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		ATAATGATGACGGGAGACGGA	0.403000													36	53					0	0	1	0	0	
MICAL2	9645	broad.mit.edu	37	11	12247894	12247894	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:12247894G>A	uc001mjz.2	+	14	2153	c.1865G>A	c.(1864-1866)CGG>CAG	p.R622Q	MICAL2_uc010rch.1_Missense_Mutation_p.R622Q|MICAL2_uc001mka.2_Missense_Mutation_p.R622Q|MICAL2_uc010rci.1_Missense_Mutation_p.R622Q|MICAL2_uc001mkb.2_Missense_Mutation_p.R622Q|MICAL2_uc001mkc.2_Missense_Mutation_p.R622Q|MICAL2_uc001mkd.2_Missense_Mutation_p.R451Q|MICAL2_uc010rcj.1_Missense_Mutation_p.R24Q	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	622						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GAGCTCTTCCGGGGCACCCCA	0.587000													26	36					0	0	1	0	0	
MICAL2	9645	broad.mit.edu	37	11	12247914	12247914	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:12247914G>A	uc001mjz.2	+	14	2173	c.1885G>A	c.(1885-1887)GTG>ATG	p.V629M	MICAL2_uc010rch.1_Missense_Mutation_p.V629M|MICAL2_uc001mka.2_Missense_Mutation_p.V629M|MICAL2_uc010rci.1_Missense_Mutation_p.V629M|MICAL2_uc001mkb.2_Missense_Mutation_p.V629M|MICAL2_uc001mkc.2_Missense_Mutation_p.V629M|MICAL2_uc001mkd.2_Missense_Mutation_p.V458M|MICAL2_uc010rcj.1_Missense_Mutation_p.V31M	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	629						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		ACTGAGGCCCGTGGGTAAGCA	0.572000													20	36					0	0	1	0	0	
MRGPRX1	259249	broad.mit.edu	37	11	18955440	18955440	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:18955440C>T	uc001mpg.2	-	1	1110	c.892G>A	c.(892-894)GCG>ACG	p.A298T		NM_147199	NP_671732	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	298	Cytoplasmic (Potential).			AS -> TP (in Ref. 2; AAL86880).	acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(2)|central_nervous_system(1)	3						ACCTCAGACGCGTCCTGCAGA	0.562000													22	47					0	0	1	0	0	
E2F8	79733	broad.mit.edu	37	11	19256596	19256596	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:19256596C>T	uc001mpm.2	-	5	983	c.461G>A	c.(460-462)CGT>CAT	p.R154H	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.R154H	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	154	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						AATGCGTCGACGTTCAACATC	0.413000													5	16					0	0	1	0	0	
NAV2	89797	broad.mit.edu	37	11	20104605	20104605	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:20104605C>T	uc001mpr.3	+	26	5748	c.5387C>T	c.(5386-5388)GCG>GTG	p.A1796V	NAV2_uc001mpp.2_Missense_Mutation_p.A1729V|NAV2_uc009yhx.2_Missense_Mutation_p.A857V|NAV2_uc009yhz.2_Missense_Mutation_p.A438V|NAV2_uc001mpu.2_Missense_Mutation_p.A231V	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1	1852						nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						CCAAAATCTGCGTCCTCTCAT	0.498000													20	28					0	0	1	0	0	
ANO5	203859	broad.mit.edu	37	11	22272355	22272355	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:22272355A>T	uc001mqi.2	+	11	1399	c.1082A>T	c.(1081-1083)GAT>GTT	p.D361V	ANO5_uc001mqj.2_Missense_Mutation_p.D360V	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	361	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						CAAGTGTGTGATTATTGGAGA	0.383000													44	55					0	0	1	0	0	
BDNF	627	broad.mit.edu	37	11	27680000	27680000	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:27680000G>A	uc010rdu.1	-	2	963	c.112C>T	c.(112-114)CGG>TGG	p.R38W	BDNFOS_uc001mrm.2_RNA|BDNFOS_uc009yij.2_RNA|BDNFOS_uc009yik.2_RNA|BDNFOS_uc009yil.2_RNA|BDNFOS_uc001mrp.2_RNA|BDNFOS_uc009yim.2_RNA|BDNFOS_uc009yin.2_RNA|BDNFOS_uc009yio.2_RNA|BDNFOS_uc009yip.2_RNA|BDNFOS_uc001mrn.2_RNA|BDNFOS_uc009yiq.2_RNA|BDNFOS_uc001mro.2_RNA|BDNFOS_uc009yir.2_RNA|BDNFOS_uc009yis.2_Intron|BDNFOS_uc009yit.2_RNA|BDNFOS_uc009yiu.2_RNA|BDNFOS_uc009yiv.2_RNA|BDNFOS_uc009yiw.2_RNA|BDNFOS_uc009yix.2_RNA|BDNFOS_uc009yiy.2_RNA|BDNFOS_uc009yiz.2_RNA|BDNFOS_uc001mrq.3_RNA|BDNFOS_uc001mrr.3_RNA|BDNFOS_uc009yja.2_RNA|BDNFOS_uc009yjb.2_RNA|BDNF_uc010rdv.1_Missense_Mutation_p.R38W|BDNF_uc001mrt.2_Missense_Mutation_p.R53W|BDNF_uc010rdw.1_Missense_Mutation_p.R38W|BDNF_uc009yjd.2_Missense_Mutation_p.R38W|BDNF_uc001mru.2_Missense_Mutation_p.R38W|BDNF_uc010rdx.1_Missense_Mutation_p.R38W|BDNF_uc010rdy.1_Missense_Mutation_p.R38W|BDNF_uc009yjg.2_Missense_Mutation_p.R38W|BDNF_uc009yje.2_Missense_Mutation_p.R120W|BDNF_uc009yjf.2_Missense_Mutation_p.R67W|BDNF_uc001mrv.2_Missense_Mutation_p.R38W|BDNF_uc001mrw.3_Missense_Mutation_p.R38W|BDNF_uc001mrx.2_Missense_Mutation_p.R38W|BDNF_uc001mry.3_Missense_Mutation_p.R38W|BDNF_uc001mrz.3_Missense_Mutation_p.R38W|BDNF_uc001msa.2_Missense_Mutation_p.R46W	NM_001143816	NP_001137288	P23560	BDNF_HUMAN	brain-derived neurotrophic factor isoform a	38						extracellular region	growth factor activity				0						CCATGGGTCCGCACACCTGGG	0.507000													53	67					0	0	1	0	0	
QSER1	79832	broad.mit.edu	37	11	32953667	32953667	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:32953667C>T	uc001mty.2	+	4	743	c.476C>T	c.(475-477)TCC>TTC	p.S159F	QSER1_uc001mtz.1_Missense_Mutation_p.S159F|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	159	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					CTTGGGGGATCCCAGCAGACT	0.443000													59	92					0	0	1	0	0	
C11orf74	119710	broad.mit.edu	37	11	36669606	36669606	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:36669606C>T	uc001mwy.1	+	5	472	c.399C>T	c.(397-399)AGC>AGT	p.S133S	C11orf74_uc010rfd.1_RNA|C11orf74_uc001mww.1_Silent_p.S59S|C11orf74_uc001mwx.1_RNA|C11orf74_uc001mwz.1_Silent_p.S59S|C11orf74_uc010rfe.1_RNA	NM_138787	NP_620142	Q86VG3	CK074_HUMAN	hypothetical protein LOC119710	133											0	all_lung(20;0.226)	all_hematologic(20;0.0118)				AGGATGTAAGCACCAGCATTC	0.458000													69	106					0	0	1	0	0	
TTC17	55761	broad.mit.edu	37	11	43427343	43427343	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:43427343G>A	uc001mxi.2	+	13	1617	c.1603G>A	c.(1603-1605)GAA>AAA	p.E535K	TTC17_uc001mxh.2_Missense_Mutation_p.E535K|TTC17_uc010rfj.1_Missense_Mutation_p.E478K|TTC17_uc001mxj.2_Missense_Mutation_p.E305K	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	535							binding			ovary(5)	5						CAGGATCCACGAACTCAGCAG	0.413000													32	67					0	0	1	0	0	
TTC17	55761	broad.mit.edu	37	11	43511893	43511893	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:43511893G>A	uc001mxi.2	+	22	3149	c.3135G>A	c.(3133-3135)GCG>GCA	p.A1045A	TTC17_uc010rfj.1_Silent_p.A1045A|TTC17_uc001mxl.2_Silent_p.A101A|TTC17_uc001mxm.2_Silent_p.A26A	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1045	TPR 4.						binding			ovary(5)	5						TGCACTATGCGCCACACCAGA	0.567000													30	48					0	0	1	0	0	
AMBRA1	55626	broad.mit.edu	37	11	46419316	46419316	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:46419316G>A	uc010rgu.1	-	18	3941	c.3581C>T	c.(3580-3582)ACG>ATG	p.T1194M	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.T1165M|AMBRA1_uc001ncu.1_Missense_Mutation_p.T1104M|AMBRA1_uc001ncv.2_Missense_Mutation_p.T1197M|AMBRA1_uc001ncw.2_Missense_Mutation_p.T1075M|AMBRA1_uc001ncx.2_Missense_Mutation_p.T1134M	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1194					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		TTCAGTGCCCGTCTGAGAGCT	0.667000													15	28					0	0	1	0	0	
CKAP5	9793	broad.mit.edu	37	11	46804910	46804910	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:46804910T>C	uc001ndi.1	-	18	2273	c.2163A>G	c.(2161-2163)TCA>TCG	p.S721S	CKAP5_uc009ylg.1_Silent_p.S607S|CKAP5_uc001ndj.1_Silent_p.S721S	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	721					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						AGAAAGCCATTGACACAACCT	0.353000													22	42					0	0	1	0	0	
CKAP5	9793	broad.mit.edu	37	11	46819663	46819663	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:46819663C>T	uc001ndi.1	-	10	1253	c.1143G>A	c.(1141-1143)CTG>CTA	p.L381L	CKAP5_uc009ylg.1_Silent_p.L267L|CKAP5_uc001ndj.1_Silent_p.L381L	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	381	HEAT 2.				cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						TTGCCTCCTGCAGGGCTTGTA	0.338000													51	90					0	0	1	0	0	
MADD	8567	broad.mit.edu	37	11	47312287	47312287	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:47312287G>A	uc001ner.1	+	20	3472	c.3281G>A	c.(3280-3282)CGG>CAG	p.R1094Q	MADD_uc001neq.2_Missense_Mutation_p.R1074Q|MADD_uc001nev.1_Missense_Mutation_p.R1031Q|MADD_uc001nes.1_Missense_Mutation_p.R1051Q|MADD_uc001net.1_Missense_Mutation_p.R1094Q|MADD_uc009yln.1_Missense_Mutation_p.R1031Q|MADD_uc001neu.1_Missense_Mutation_p.R1031Q|MADD_uc001nex.2_Missense_Mutation_p.R1094Q|MADD_uc001nez.2_Missense_Mutation_p.R1031Q|MADD_uc001new.2_Missense_Mutation_p.R1074Q|MADD_uc009ylo.2_Missense_Mutation_p.R12Q	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1094					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		CTGGGACCTCGGGCACCAAGT	0.498000													17	30					0	0	1	0	0	
CELF1	10658	broad.mit.edu	37	11	47504307	47504307	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:47504307G>A	uc001nfl.2	-	6	637	c.627C>T	c.(625-627)AGC>AGT	p.S209S	CELF1_uc001nfm.2_Silent_p.S209S|CELF1_uc001nfn.2_Silent_p.S209S|CELF1_uc001nfo.1_Silent_p.S235S|CELF1_uc010rhm.1_Silent_p.S208S|CELF1_uc001nfp.2_Silent_p.S236S|CELF1_uc001nfq.1_Silent_p.S209S|CELF1_uc001nfr.1_Silent_p.S209S	NM_001025596	NP_001020767	Q92879	CELF1_HUMAN	CUG triplet repeat, RNA-binding protein 1	209					embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|ovary(1)	3						CAGATGCTGCGCTGATTTGCT	0.483000													31	43					0	0	1	0	0	
C1QTNF4	114900	broad.mit.edu	37	11	47612294	47612294	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:47612294C>T	uc001ngc.2	-	2	336	c.69G>A	c.(67-69)CCG>CCA	p.P23P		NM_031909	NP_114115	Q9BXJ3	C1QT4_HUMAN	C1q and tumor necrosis factor related protein 4	23						extracellular region					0						CAGAGGATCCCGGGCCGGGGG	0.721000													8	11					0	0	1	0	0	
OR4C16	219428	broad.mit.edu	37	11	55339828	55339828	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:55339828A>G	uc010rih.1	+	1	225	c.225A>G	c.(223-225)ATA>ATG	p.I75M		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				CTACTTCCATAACCCCTAGAA	0.423000													65	103					0	0	1	0	0	
OR8J3	81168	broad.mit.edu	37	11	55904902	55904902	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:55904902G>A	uc010riz.1	-	1	293	c.293C>T	c.(292-294)GCC>GTC	p.A98V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					CAGTTGGGTGGCACATTCATA	0.433000													5	113					0	0	1	0	0	
OR8H1	219469	broad.mit.edu	37	11	56058538	56058538	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:56058538T>C	uc010rje.1	-	1	1	c.1A>G	c.(1-3)ATG>GTG	p.M1V		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					CTTCTACCCATGATGTTCAAT	0.358000													28	64					0	0	1	0	0	
OR8J1	219477	broad.mit.edu	37	11	56128015	56128015	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:56128015C>T	uc010rjh.1	+	1	293	c.293C>T	c.(292-294)GCC>GTC	p.A98V		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TATGAATGTGCCACCCAACTG	0.418000													30	57					0	0	1	0	0	
OR8J1	219477	broad.mit.edu	37	11	56128086	56128086	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:56128086C>T	uc010rjh.1	+	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGCCTATGACCGCTATGTGGC	0.493000													29	58					0	0	1	0	0	
OR9Q1	219956	broad.mit.edu	37	11	57947085	57947085	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:57947085G>A	uc001nmj.2	+	3	485	c.169G>A	c.(169-171)GCT>ACT	p.A57T		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	57	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				CCAGCTCCACGCTCCAATGTA	0.488000													17	163					0	0	1	0	0	
MS4A14	84689	broad.mit.edu	37	11	60183894	60183894	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:60183894C>T	uc001npj.2	+	5	2018	c.1453C>T	c.(1453-1455)CGG>TGG	p.R485W	MS4A14_uc001npi.2_Missense_Mutation_p.R373W|MS4A14_uc001npn.2_Missense_Mutation_p.R223W|MS4A14_uc001npk.2_Missense_Mutation_p.R468W|MS4A14_uc001npl.2_Missense_Mutation_p.R223W|MS4A14_uc001npm.2_Missense_Mutation_p.R223W	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	485	Gln-rich.					integral to membrane	receptor activity			breast(1)	1						ATCCTCAAGACGGCATTCCTT	0.388000													45	66					0	0	1	0	0	
MS4A5	64232	broad.mit.edu	37	11	60215121	60215121	+	Splice_Site	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:60215121G>T	uc001npo.2	+	5	579	c.493_splice	c.e5-1	p.G165_splice		NM_023945	NP_076434	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member							integral to membrane	receptor activity			large_intestine(1)|ovary(1)	2						TTCTATTACAGGGAATTTTGA	0.348000													25	47					1.96895e-08	2.03435e-08	1	1	0	
HNRNPUL2	221092	broad.mit.edu	37	11	62490153	62490153	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:62490153G>A	uc001nuw.2	-	6	1208	c.1015C>T	c.(1015-1017)CGA>TGA	p.R339*	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	339	B30.2/SPRY.				cell killing	nucleus	ATP binding|nucleic acid binding				0						TTGAGTCCTCGTCCATCGAAA	0.418000													40	63					0	0	1	0	0	
ZBTB3	79842	broad.mit.edu	37	11	62519825	62519825	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:62519825G>A	uc001nuz.2	-	2	1584	c.1462C>T	c.(1462-1464)CGG>TGG	p.R488W		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	488	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						GCATGTCGCCGTAGTGTGTAA	0.562000													21	34					0	0	1	0	0	
FERMT3	83706	broad.mit.edu	37	11	63990891	63990891	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:63990891G>A	uc001nyl.2	+	15	2080	c.1931G>A	c.(1930-1932)CGG>CAG	p.R644Q	FERMT3_uc001nym.2_Missense_Mutation_p.R640Q|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	644					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						CTGTCGACGCGGGAGCGGGCC	0.592000													17	40					0	0	1	0	0	
CCDC88B	283234	broad.mit.edu	37	11	64112079	64112079	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:64112079C>T	uc001nzy.2	+	14	2110	c.2066C>T	c.(2065-2067)ACG>ATG	p.T689M	CCDC88B_uc009ypo.1_Missense_Mutation_p.T686M|CCDC88B_uc001nzz.1_Missense_Mutation_p.T338M	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	689					microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						CTGGAAGGGACGGTCAGGGAC	0.637000													3	6					0	0	1	0	0	
NRXN2	9379	broad.mit.edu	37	11	64390500	64390500	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:64390500G>A	uc001oap.2	-	6	1271	c.760C>T	c.(760-762)CGG>TGG	p.R254W	NRXN2_uc001oar.2_Missense_Mutation_p.R1300W|NRXN2_uc001oas.2_Missense_Mutation_p.R1230W|NRXN2_uc001oao.2_5'UTR|NRXN2_uc001oaq.2_Missense_Mutation_p.R967W	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	254	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCCTGATCCCGGCCCCCGATC	0.522000													5	17					0	0	1	0	0	
CDC42BPG	55561	broad.mit.edu	37	11	64597667	64597667	+	Silent	SNP	G	A	A	rs142016620		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:64597667G>A	uc001obs.3	-	29	3366	c.3366C>T	c.(3364-3366)AAC>AAT	p.N1122N		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1122	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						GATAGGTACCGTTGCTGCGCA	0.493000													10	20					0	0	1	0	0	
SAC3D1	29901	broad.mit.edu	37	11	64812092	64812092	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:64812092A>G	uc001ocm.2	+	2	1359	c.970A>G	c.(970-972)ACG>GCG	p.T324A	SAC3D1_uc010rnv.1_Missense_Mutation_p.T311A	NM_013299	NP_037431			SAC3 domain containing 1												0						GCCTGCCAGTACGTGCAAGGT	0.627000													4	64					0	0	1	0	0	
SYVN1	84447	broad.mit.edu	37	11	64897648	64897648	+	Splice_Site	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:64897648C>T	uc001odb.2	-	13	1329	c.1235_splice	c.e13-1	p.A412_splice	SYVN1_uc001odc.2_Intron|SYVN1_uc009yqc.2_Intron	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b						ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						GAAAGGGCTGCTGAAGAGCAG	0.612000													11	17					0	0	1	0	0	
MALAT1	378938	broad.mit.edu	37	11	65272702	65272702	+	RNA	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:65272702T>C	uc010roh.1	+	1		c.7470T>C			uc001ody.2_5'Flank	NR_002819				Homo sapiens clone alpha1 mRNA sequence.												0						AGGACAACCATGGAGCCTTCC	0.488000													15	23					0	0	1	0	0	
EHBP1L1	254102	broad.mit.edu	37	11	65350743	65350743	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:65350743G>A	uc001oeo.3	+	9	2865	c.2600G>A	c.(2599-2601)CGT>CAT	p.R867H	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	867	Glu-rich.									central_nervous_system(1)	1						CTGATGACCCGTAAGACAGAA	0.557000													18	28					0	0	1	0	0	
SIPA1	6494	broad.mit.edu	37	11	65417119	65417119	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:65417119T>C	uc001ofb.2	+	11	2780	c.2613T>C	c.(2611-2613)GCT>GCC	p.A871A	SIPA1_uc010rom.1_Silent_p.A769A|SIPA1_uc001ofd.2_Silent_p.A871A	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	871					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						TACCCAGTGCTGACAGTGAGA	0.607000													35	63					0	0	1	0	0	
CST6	1474	broad.mit.edu	37	11	65779667	65779667	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:65779667C>T	uc001ogr.2	+	1	206	c.152C>T	c.(151-153)GCG>GTG	p.A51V	CST6_uc001ogq.1_RNA|CST6_uc001ogs.1_5'Flank	NM_001323	NP_001314	Q15828	CYTM_HUMAN	cystatin M precursor	51					anatomical structure morphogenesis	extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1						GTGCAGAAGGCGGCGCAGGCG	0.701000													3	6					0	0	1	0	0	
CD248	57124	broad.mit.edu	37	11	66084119	66084119	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:66084119G>A	uc001ohm.1	-	1	397	c.380C>T	c.(379-381)CCG>CTG	p.P127L		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	127	C-type lectin.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GCGCTGGGCCGGGCAGGGGCC	0.697000													14	31					0	0	1	0	0	
SPTBN2	6712	broad.mit.edu	37	11	66458926	66458926	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:66458926G>A	uc001ojd.2	-	26	5466	c.5394C>T	c.(5392-5394)GCC>GCT	p.A1798A		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1798	Spectrin 14.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CGTACGCCGCGGCCAGCACCT	0.701000													16	10					0	0	1	0	0	
PC	5091	broad.mit.edu	37	11	66639172	66639172	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:66639172T>C	uc001ojn.1	-	3	356	c.307A>G	c.(307-309)ATC>GTC	p.I103V	PC_uc001ojo.1_Missense_Mutation_p.I103V|PC_uc001ojp.1_Missense_Mutation_p.I103V	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	103	Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	GCCACCTTGATGATGTCTGGG	0.652000													4	4					0	0	1	0	0	
RHOD	29984	broad.mit.edu	37	11	66838982	66838982	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:66838982C>T	uc001ojv.2	+	5	627	c.542C>T	c.(541-543)GCC>GTC	p.A181V		NM_014578	NP_055393	O00212	RHOD_HUMAN	ras homolog D precursor	181					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0						AACGTCCACGCCGTCTTCCAG	0.687000													4	18					0	0	1	0	0	
CABP4	57010	broad.mit.edu	37	11	67225916	67225916	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:67225916G>A	uc001olo.2	+	5	803	c.726G>A	c.(724-726)CCG>CCA	p.P242P	CABP4_uc001oln.2_Silent_p.P137P	NM_145200	NP_660201	P57796	CABP4_HUMAN	calcium binding protein 4	242					visual perception	cytoplasm|extracellular region|terminal button	calcium ion binding				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			TCGGGGAGCCGCTGGCGGGTC	0.632000													43	58					0	0	1	0	0	
TBX10	347853	broad.mit.edu	37	11	67400555	67400555	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:67400555T>C	uc001omp.2	-	5	657	c.569A>G	c.(568-570)CAC>CGC	p.H190R		NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	190	T-box.				anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGGTAGCGGTGCATAGAGTT	0.582000													72	125					0	0	1	0	0	
SUV420H1	51111	broad.mit.edu	37	11	67934466	67934466	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:67934466T>C	uc001onm.1	-	10	1413	c.1157A>G	c.(1156-1158)CAG>CGG	p.Q386R	SUV420H1_uc009yse.1_5'UTR|SUV420H1_uc001onn.1_Missense_Mutation_p.Q214R|SUV420H1_uc009ysf.2_Missense_Mutation_p.Q146R|SUV420H1_uc001ono.1_Missense_Mutation_p.Q386R|SUV420H1_uc001onp.2_Missense_Mutation_p.Q386R|SUV420H1_uc010rqa.1_Missense_Mutation_p.Q363R|SUV420H1_uc001onq.2_Missense_Mutation_p.Q386R	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	386					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GTTTTTTTCCTGAGTGGTATC	0.328000													25	29					0	0	1	0	0	
LRP5	4041	broad.mit.edu	37	11	68153968	68153968	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:68153968G>A	uc001ont.2	+	6	1275	c.1200G>A	c.(1198-1200)GCG>GCA	p.A400A	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	400	LDL-receptor class B 6.|Beta-propeller 2.|Extracellular (Potential).		A -> E (in OPPG).		adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						TCCGCAGGGCGTACCTGGACG	0.642000													21	41					0	0	1	0	0	
LRP5	4041	broad.mit.edu	37	11	68204455	68204455	+	Missense_Mutation	SNP	G	A	A	rs28939709		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:68204455G>A	uc001ont.2	+	19	4174	c.4099G>A	c.(4099-4101)GAG>AAG	p.E1367K	LRP5_uc009ysg.2_Missense_Mutation_p.E777K	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1367	LDL-receptor class A 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CGGCTCCGACGAGCTCATGTG	0.632000													25	43					0	0	1	0	0	
MTL5	9633	broad.mit.edu	37	11	68506209	68506209	+	Silent	SNP	C	T	T	rs138790602	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:68506209C>T	uc001ooc.2	-	6	1016	c.876G>A	c.(874-876)TCG>TCA	p.S292S	MTL5_uc001ood.1_Silent_p.S292S|MTL5_uc009ysi.1_3'UTR	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	292					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			GAGTTGATCCCGAGGGGAAAG	0.403000													22	42					0	0	1	0	0	
PPFIA1	8500	broad.mit.edu	37	11	70200480	70200480	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:70200480C>T	uc001opo.2	+	17	2435	c.2237C>T	c.(2236-2238)CCG>CTG	p.P746L	PPFIA1_uc001opn.1_Missense_Mutation_p.P746L|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	746					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CCTTCCTCCCCGAGAGCCCTT	0.567000													9	26					0	0	1	0	0	
ARAP1	116985	broad.mit.edu	37	11	72423533	72423533	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:72423533G>A	uc001osu.2	-	6	1017	c.828C>T	c.(826-828)GAC>GAT	p.D276D	ARAP1_uc001osv.2_Silent_p.D276D|ARAP1_uc001osr.2_Silent_p.D36D|ARAP1_uc001oss.2_Silent_p.D31D|ARAP1_uc009yth.2_Silent_p.D31D|ARAP1_uc010rre.1_Silent_p.D31D	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	276					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						CCCCTTGGTCGTCCCCAGACA	0.682000													74	99					0	0	1	0	0	
P2RY2	5029	broad.mit.edu	37	11	72946018	72946018	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:72946018C>T	uc001otj.2	+	3	1147	c.814C>T	c.(814-816)CGC>TGC	p.R272C	P2RY2_uc001otk.2_Missense_Mutation_p.R272C|P2RY2_uc001otl.2_Missense_Mutation_p.R272C	NM_002564	NP_002555	P41231	P2RY2_HUMAN	purinergic receptor P2Y2	272	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(1)|skin(1)	4					Suramin(DB04786)	CTACTCCTTCCGCTCGCTGGA	0.632000													17	38					0	0	1	0	0	
PPME1	51400	broad.mit.edu	37	11	73950295	73950295	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:73950295C>T	uc001ouw.2	+	9	927	c.828C>T	c.(826-828)GAC>GAT	p.D276D	PPME1_uc009yty.2_Silent_p.D146D|PPME1_uc001oux.2_Silent_p.D89D	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	276					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					AGGAAGATGACATGGAGGTGG	0.403000													6	18					0	0	1	0	0	
XRRA1	143570	broad.mit.edu	37	11	74638466	74638466	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:74638466G>A	uc009yub.2	-	7	800	c.468C>T	c.(466-468)TAC>TAT	p.Y156Y	XRRA1_uc001ovm.2_Intron|XRRA1_uc001ovo.2_Intron|XRRA1_uc001ovq.3_Silent_p.Y156Y|XRRA1_uc001ovp.3_Translation_Start_Site|XRRA1_uc001ovr.2_Translation_Start_Site	NM_182969	NP_892014	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	156					response to X-ray	cytoplasm|nucleus				central_nervous_system(1)	1						CATATTTCACGTAGATAGTTT	0.433000													13	26					0	0	1	0	0	
ARRB1	408	broad.mit.edu	37	11	74994515	74994515	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:74994515A>G	uc001owe.1	-	5	392	c.170T>C	c.(169-171)CTG>CCG	p.L57P	ARRB1_uc001owf.1_Missense_Mutation_p.L57P	NM_004041	NP_004032	P49407	ARRB1_HUMAN	arrestin beta 1 isoform A	57	Interaction with CHRM2 (By similarity).|Interaction with SRC (By similarity).				G-protein coupled receptor internalization|histone H4 acetylation|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|positive regulation of histone acetylation|positive regulation of Rho protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|post-Golgi vesicle-mediated transport|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|signal transduction|stress fiber assembly|transcription from RNA polymerase II promoter	chromatin|coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane fraction|nucleus|plasma membrane|pseudopodium|soluble fraction	angiotensin receptor binding|enzyme inhibitor activity|GTPase activator activity|insulin-like growth factor receptor binding|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding			breast(2)	2						GGCGCAGGTCAGCGTCACATA	0.672000													10	23					0	0	1	0	0	
MAP6	4135	broad.mit.edu	37	11	75298331	75298331	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:75298331C>A	uc001owu.2	-	4	2280	c.2215G>T	c.(2215-2217)GGT>TGT	p.G739C		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	739	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					ACTATACGACCTTGATTCTTT	0.512000													14	153					9.16793e-09	9.48677e-09	1	1	0	
OMP	4975	broad.mit.edu	37	11	76814175	76814175	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:76814175G>A	uc010rsk.1	+	1	290	c.290G>A	c.(289-291)CGC>CAC	p.R97H	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	97					sensory perception of smell|synaptic transmission						0						CTCATGACACGCCAGCTGCTG	0.617000													10	16					0	0	1	0	0	
ME3	10873	broad.mit.edu	37	11	86209065	86209065	+	Silent	SNP	G	A	A	rs149425348	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:86209065G>A	uc001pbz.2	-	5	899	c.645C>T	c.(643-645)TGC>TGT	p.C215C	ME3_uc001pca.2_Silent_p.C215C|ME3_uc009yvk.2_Silent_p.C215C|ME3_uc010rtr.1_RNA	NM_001014811	NP_001014811	Q16798	MAON_HUMAN	mitochondrial malic enzyme 3 precursor	215					aerobic respiration|malate metabolic process|oxygen metabolic process|pyruvate metabolic process	mitochondrial matrix	malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|metal ion binding|NAD binding			ovary(1)	1		Acute lymphoblastic leukemia(157;4.34e-06)|all_hematologic(158;0.00252)			NADH(DB00157)	TCACCCCTCCGCATGCCGTGT	0.662000													43	67					0	0	1	0	0	
CTSC	1075	broad.mit.edu	37	11	88068128	88068128	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:88068128A>G	uc001pck.3	-	2	396	c.295T>C	c.(295-297)TAC>CAC	p.Y99H	CTSC_uc001pcl.3_5'UTR|CTSC_uc001pcm.3_Missense_Mutation_p.Y99H|CTSC_uc001pcn.3_Missense_Mutation_p.Y99H	NM_001814	NP_001805	P53634	CATC_HUMAN	cathepsin C isoform a preproprotein	99					immune response	lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AACCACTTGTAGTCATTCAAC	0.383000													17	39					0	0	1	0	0	
UBTFL1	642623	broad.mit.edu	37	11	89819560	89819560	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:89819560A>C	uc010rub.1	+	1	443	c.443A>C	c.(442-444)AAA>ACA	p.K148T		NM_001143975	NP_001137447	P0CB47	UBFL1_HUMAN	upstream binding transcription factor, RNA	148	HMG box 1.				multicellular organismal development	cytoplasm|nucleus	DNA binding				0						ATGAAACAGAAATATATTCAG	0.443000													10	8					0	0	1	0	0	
FAT3	120114	broad.mit.edu	37	11	92507279	92507279	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:92507279C>T	uc001pdj.3	+	6	4285	c.4268C>T	c.(4267-4269)GCA>GTA	p.A1423V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1423	Cadherin 13.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTTTGGATGCAGAGCAGAGG	0.423000										TCGA Ovarian(4;0.039)			17	40					0	0	1	0	0	
FAT3	120114	broad.mit.edu	37	11	92533807	92533807	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:92533807G>A	uc001pdj.3	+	9	7645	c.7628G>A	c.(7627-7629)CGA>CAA	p.R2543Q		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2543	Cadherin 23.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCCAAGGATCGATTCCTCATA	0.483000										TCGA Ovarian(4;0.039)			5	10					0	0	1	0	0	
FUT4	2526	broad.mit.edu	37	11	94278208	94278208	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:94278208C>T	uc001pez.2	+	1	1192	c.909C>T	c.(907-909)TCC>TCT	p.S303S	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_5'Flank	NM_002033	NP_002024	P22083	FUT4_HUMAN	fucosyltransferase 4	303	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			skin(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CCTCGCACTCCCCGGGGCTGC	0.662000													9	23					0	0	1	0	0	
PGR	5241	broad.mit.edu	37	11	100933308	100933308	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:100933308A>G	uc001pgh.2	-	4	2825	c.2082T>C	c.(2080-2082)ATT>ATC	p.I694I	PGR_uc001pgg.2_Silent_p.I75I|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	694	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CATCTGGTTCAATGCTCATTA	0.438000													93	142					0	0	1	0	0	
PGR	5241	broad.mit.edu	37	11	100998809	100998809	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:100998809G>A	uc001pgh.2	-	1	1736	c.993C>T	c.(991-993)GGC>GGT	p.G331G	PGR_uc001pgi.2_Silent_p.G331G|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	331	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CCCCGGCCCCGCCGTCGTAAC	0.662000													23	20					0	0	1	0	0	
PGR	5241	broad.mit.edu	37	11	100999101	100999101	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:100999101C>A	uc001pgh.2	-	1	1444	c.701G>T	c.(700-702)GGT>GTT	p.G234V	PGR_uc001pgi.2_Missense_Mutation_p.G234V|PGR_uc009yww.1_RNA|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA|uc010rum.1_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	234	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	CAGAAGCGGACCCGCAGACTC	0.726000													4	17					0.00909568	0.00915813	1	1	0	
RDX	5962	broad.mit.edu	37	11	110128524	110128524	+	Silent	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:110128524A>C	uc001pku.2	-	7	976	c.666T>G	c.(664-666)GCT>GCG	p.A222A	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Silent_p.A222A|RDX_uc009yxz.2_Intron|RDX_uc009yya.2_Intron|RDX_uc010rwe.1_Silent_p.A86A	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	222	FERM.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		TCAGACCCAAAGCATCAACAC	0.338000													52	94					0	0	1	0	0	
ZBTB16	7704	broad.mit.edu	37	11	114118084	114118084	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:114118084A>C	uc001pop.2	+	6	2053	c.1789A>C	c.(1789-1791)ACA>CCA	p.T597P	ZBTB16_uc001poq.2_Missense_Mutation_p.T597P	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	597					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		TAGGGTGCACACAGGTACCGA	0.582000													17	28					0	0	1	0	0	
FAM55A	120400	broad.mit.edu	37	11	114393092	114393092	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:114393092T>C	uc001ppa.2	-	6	1233	c.816A>G	c.(814-816)ATA>ATG	p.I272M	FAM55A_uc010rxd.1_Missense_Mutation_p.I121M	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	414						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		AATCATGATCTATCAGAGAGT	0.423000													33	71					0	0	1	0	0	
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:115080343G>T	uc001ppi.3	-	8	1158	c.1029C>A	c.(1027-1029)ACC>ACA	p.T343T	CADM1_uc001ppf.3_Intron|CADM1_uc001ppk.3_Intron|CADM1_uc001ppj.3_Intron|CADM1_uc001pph.3_Silent_p.T95T	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	343	Extracellular (Potential).			PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.269000													21	26					1.96292e-10	2.04979e-10	1	1	0	
APOA4	337	broad.mit.edu	37	11	116692194	116692194	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:116692194C>T	uc001pps.1	-	3	684	c.580G>A	c.(580-582)GTG>ATG	p.V194M		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		AGCTCCTCCACGTTCTGGTCG	0.637000													84	143					0	0	1	0	0	
APOA1	335	broad.mit.edu	37	11	116707074	116707074	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:116707074C>T	uc001ppu.1	-	4	333	c.254G>A	c.(253-255)CGC>CAC	p.R85H	APOA1_uc001ppv.1_Missense_Mutation_p.R85H	NM_000039	NP_000030	P02647	APOA1_HUMAN	apolipoprotein A-I preproprotein	85	10 X approximate tandem repeats.|1.				Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|cholesterol import|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|negative regulation of cytokine secretion involved in immune response|negative regulation of interleukin-1 beta secretion|negative regulation of very-low-density lipoprotein particle remodeling|phosphatidylcholine biosynthetic process|phospholipid efflux|platelet activation|platelet degranulation|positive regulation of cholesterol esterification|positive regulation of hydrolase activity|protein stabilization|reverse cholesterol transport	endocytic vesicle|endoplasmic reticulum lumen|plasma membrane|spherical high-density lipoprotein particle|stored secretory granule|very-low-density lipoprotein particle	apolipoprotein A-I receptor binding|beta-amyloid binding|cholesterol binding|cholesterol transporter activity|enzyme binding|high-density lipoprotein particle receptor binding|identical protein binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.59e-05)|all cancers(92;0.000162)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GAGCTGTTCGCGCAGCTTGCT	0.602000													18	46					0	0	1	0	0	
SIK3	23387	broad.mit.edu	37	11	116719913	116719913	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:116719913G>A	uc001ppy.2	-	21	3460	c.3424C>T	c.(3424-3426)CGC>TGC	p.R1142C	SIK3_uc001ppz.2_Missense_Mutation_p.R981C|SIK3_uc001pqa.2_Missense_Mutation_p.R1082C|SIK3_uc001ppw.2_Missense_Mutation_p.R499C|SIK3_uc001ppx.2_Missense_Mutation_p.R520C	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	1142						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						ACGGAGGGGCGTGCTGGGTAC	0.592000													23	50					0	0	1	0	0	
SIK3	23387	broad.mit.edu	37	11	116745890	116745890	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:116745890C>A	uc001ppy.2	-	11	1273	c.1237G>T	c.(1237-1239)GGT>TGT	p.G413C	SIK3_uc001ppz.2_Missense_Mutation_p.G312C|SIK3_uc001pqa.2_Missense_Mutation_p.G365C	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	413						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						TCAGCCACACCCACTGTGTGC	0.532000													19	27					1.33834e-09	1.3926e-09	1	1	0	
SIK3	23387	broad.mit.edu	37	11	116746643	116746643	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:116746643C>T	uc001ppy.2	-	9	1040	c.1004G>A	c.(1003-1005)CGT>CAT	p.R335H	SIK3_uc001ppz.2_Missense_Mutation_p.R234H|SIK3_uc001pqa.2_Intron	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	335						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						TGCTCCGAGACGCAGGGTTTT	0.483000													40	57					0	0	1	0	0	
IL10RA	3587	broad.mit.edu	37	11	117860269	117860269	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:117860269C>T	uc001prv.2	+	3	378	c.301C>T	c.(301-303)CGG>TGG	p.R101W	IL10RA_uc010rxl.1_Missense_Mutation_p.R81W|IL10RA_uc010rxm.1_Missense_Mutation_p.R81W|IL10RA_uc010rxn.1_Intron|IL10RA_uc001prw.2_5'UTR	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	101	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GGCCAGAGTGCGGGCTGTGGA	0.577000													4	56					0	0	1	0	0	
MPZL2	10205	broad.mit.edu	37	11	118130911	118130911	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:118130911A>G	uc001psn.2	-	4	583	c.442T>C	c.(442-444)TTC>CTC	p.F148L	MPZL2_uc001pso.2_Missense_Mutation_p.F148L|MPZL2_uc001psp.1_Missense_Mutation_p.F148L	NM_005797	NP_005788	O60487	MPZL2_HUMAN	myelin protein zero-like 2 precursor	148	Extracellular (Potential).				anatomical structure morphogenesis|homophilic cell adhesion	cytoskeleton|integral to membrane				skin(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		ATCTCAGAGAAGCGTACTGTA	0.388000													40	70					0	0	1	0	0	
MLL	4297	broad.mit.edu	37	11	118365419	118365419	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:118365419G>A	uc001pta.2	+	18	5314	c.5291G>A	c.(5290-5292)CGT>CAT	p.R1764H	MLL_uc001ptb.2_Missense_Mutation_p.R1767H	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1764					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		CAAATGGAACGTGTTTTTCCA	0.328000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								8	26					0	0	1	0	0	
PHLDB1	23187	broad.mit.edu	37	11	118499081	118499081	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:118499081T>C	uc001ptr.1	+	7	1895	c.1542T>C	c.(1540-1542)CGT>CGC	p.R514R	PHLDB1_uc001pts.2_Silent_p.R514R|PHLDB1_uc001ptt.2_Silent_p.R514R|PHLDB1_uc001ptu.1_Intron|PHLDB1_uc001ptv.1_Silent_p.R314R|PHLDB1_uc001ptw.1_5'Flank	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	514											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CACGGGGCCGTAGGACACGGA	0.657000													15	13					0	0	1	0	0	
RNF26	79102	broad.mit.edu	37	11	119206681	119206681	+	Silent	SNP	C	A	A	rs145563235		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:119206681C>A	uc001pwh.2	+	1	1445	c.849C>A	c.(847-849)GGC>GGA	p.G283G		NM_032015	NP_114404	Q9BY78	RNF26_HUMAN	ring finger protein 26	283							zinc ion binding			ovary(1)	1		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.8e-05)		TAGCACTGGGCTCAGAGGCCT	0.672000													5	61					0.000602214	0.000609638	1	1	0	
C11orf63	79864	broad.mit.edu	37	11	122774667	122774667	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:122774667C>T	uc001pym.2	+	3	676	c.379C>T	c.(379-381)CGC>TGC	p.R127C	C11orf63_uc001pyl.1_Missense_Mutation_p.R127C	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	127										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		TTCAGACCTCCGCTATGACCC	0.458000													111	157					0	0	1	0	0	
OR10S1	219873	broad.mit.edu	37	11	123848364	123848364	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:123848364A>G	uc001pzm.1	-	1	35	c.35T>C	c.(34-36)ATG>ACG	p.M12T		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTCCGTTGTCATGGTCATCTT	0.468000													48	64					0	0	1	0	0	
OR8D1	283159	broad.mit.edu	37	11	124180467	124180467	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:124180467A>G	uc010sag.1	-	1	196	c.196T>C	c.(196-198)TTG>CTG	p.L66L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		ACGAAGGACAAGCTGCTGAGG	0.468000													19	48					0	0	1	0	0	
ROBO3	64221	broad.mit.edu	37	11	124744032	124744032	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:124744032C>T	uc001qbc.2	+	12	2043	c.1851C>T	c.(1849-1851)AGC>AGT	p.S617S	ROBO3_uc010saq.1_5'Flank|ROBO3_uc001qbd.2_5'Flank|ROBO3_uc010sar.1_5'Flank|ROBO3_uc001qbe.2_5'Flank	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	617	Fibronectin type-III 1.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		ACACAGTCAGCGGTCTGCAGC	0.587000													44	88					0	0	1	0	0	
ROBO3	64221	broad.mit.edu	37	11	124748587	124748587	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:124748587C>A	uc001qbc.2	+	23	3620	c.3428C>A	c.(3427-3429)TCT>TAT	p.S1143Y	ROBO3_uc001qbd.2_Missense_Mutation_p.S68Y|ROBO3_uc010sar.1_Missense_Mutation_p.S192Y|ROBO3_uc001qbe.2_Missense_Mutation_p.S68Y|ROBO3_uc001qbf.1_Missense_Mutation_p.S27Y	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1143	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		GAAACCCCCTCTCCCACACCT	0.622000													16	19					0.00741294	0.00747851	1	1	0	
ADAMTS8	11095	broad.mit.edu	37	11	130278465	130278465	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:130278465C>T	uc001qgg.3	-	8	2351	c.1993G>A	c.(1993-1995)GGC>AGC	p.G665S	ADAMTS8_uc001qgf.2_Missense_Mutation_p.G146S	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	665	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		TGGTCACAGCCGGCCTTGACA	0.627000													25	66					0	0	1	0	0	
JAM3	83700	broad.mit.edu	37	11	133938946	133938946	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:133938946C>T	uc001qhb.1	+	1	127	c.103C>T	c.(103-105)CGC>TGC	p.R35C	JAM3_uc009zcz.1_Missense_Mutation_p.R35C	NM_032801	NP_116190	Q9BX67	JAM3_HUMAN	junctional adhesion molecule 3 precursor	Error:Variant_position_missing_in_Q9BX67_after_alignment					angiogenesis|blood coagulation|regulation of neutrophil chemotaxis	cell-cell contact zone|desmosome|extracellular space|integral to membrane	integrin binding			ovary(1)	1	all_hematologic(175;0.127)	all_cancers(12;1.06e-21)|all_epithelial(12;3.37e-16)|all_lung(97;7.03e-06)|Lung NSC(97;1.67e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0506)|Esophageal squamous(93;0.0566)		Epithelial(10;1.55e-09)|BRCA - Breast invasive adenocarcinoma(10;1.35e-08)|all cancers(11;2.81e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00402)|Lung(977;0.245)		CAAGCCGCGCCGCGCTGCCGC	0.741000													6	16					0	0	1	0	0	
B4GALNT3	283358	broad.mit.edu	37	12	662743	662743	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:662743G>A	uc001qii.1	+	14	1654	c.1654G>A	c.(1654-1656)GCT>ACT	p.A552T	B4GALNT3_uc001qij.1_Missense_Mutation_p.A455T|B4GALNT3_uc001qik.1_Missense_Mutation_p.A101T	NM_173593	NP_775864	Q6L9W6	B4GN3_HUMAN	beta	552	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			ovary(1)|skin(1)	2	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GCCCAGGCCCGCTGGTGACAG	0.642000													18	40					0	0	1	0	0	
DCP1B	196513	broad.mit.edu	37	12	2058419	2058419	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:2058419C>T	uc001qjx.1	-	8	1686	c.1606G>A	c.(1606-1608)GTC>ATC	p.V536I	DCP1B_uc010sdy.1_Missense_Mutation_p.V434I	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	536					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			TTTGGCGGGACGGAGGTGGGT	0.627000													14	22					0	0	1	0	0	
CACNA1C	775	broad.mit.edu	37	12	2717706	2717706	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:2717706C>T	uc009zdu.1	+	28	3759	c.3446C>T	c.(3445-3447)ACG>ATG	p.T1149M	CACNA1C_uc009zdv.1_Missense_Mutation_p.T1126M|CACNA1C_uc001qkb.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkc.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qke.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkf.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qjz.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkd.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkg.2_Missense_Mutation_p.T1129M|CACNA1C_uc009zdw.1_Missense_Mutation_p.T1129M|CACNA1C_uc001qkh.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkl.2_Missense_Mutation_p.T1149M|CACNA1C_uc001qkn.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qko.2_Missense_Mutation_p.T1149M|CACNA1C_uc001qkp.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkr.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qku.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkq.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qks.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qkt.2_Missense_Mutation_p.T1129M|CACNA1C_uc001qka.1_Missense_Mutation_p.T664M|CACNA1C_uc001qki.1_Missense_Mutation_p.T865M|CACNA1C_uc001qkj.1_Missense_Mutation_p.T865M|CACNA1C_uc001qkk.1_Missense_Mutation_p.T865M|CACNA1C_uc001qkm.1_Missense_Mutation_p.T865M	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1149	Extracellular (Potential).|III.|Dihydropyridine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GACTCCCACACGGAAGACAAG	0.428000													4	13					0	0	1	0	0	
ANO2	57101	broad.mit.edu	37	12	5939605	5939605	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:5939605C>T	uc001qnm.2	-	6	896	c.824G>A	c.(823-825)CGC>CAC	p.R275H		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	280	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						ACTTACAATGCGGCTGCGGGT	0.493000													8	9					0	0	1	0	0	
LPAR5	57121	broad.mit.edu	37	12	6729439	6729439	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:6729439G>A	uc009zer.2	-	2	1257	c.976C>T	c.(976-978)CGG>TGG	p.R326W	LPAR5_uc001qps.2_Missense_Mutation_p.R326W|LPAR5_uc010sff.1_Missense_Mutation_p.R326W	NM_001142961	NP_001136433	Q9H1C0	LPAR5_HUMAN	lysophosphatidic acid receptor 5	326	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2						AGCGCCGCCCGCGTCCCGTTG	0.721000													8	6					0	0	1	0	0	
COPS7A	50813	broad.mit.edu	37	12	6840179	6840179	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:6840179G>A	uc001qqj.2	+	8	1041	c.802G>A	c.(802-804)GCC>ACC	p.A268T	COPS7A_uc009zex.2_RNA|COPS7A_uc001qqk.2_Missense_Mutation_p.R217H|COPS7A_uc001qql.2_RNA|COPS7A_uc001qqh.2_Missense_Mutation_p.A268T|COPS7A_uc001qqi.2_Missense_Mutation_p.A268T|COPS7A_uc001qqm.2_RNA|COPS7A_uc001qqn.3_Missense_Mutation_p.A268T|COPS7A_uc001qqo.2_Missense_Mutation_p.A268T	NM_001164094	NP_001157566	Q9UBW8	CSN7A_HUMAN	COP9 complex subunit 7a	268					cullin deneddylation	cytoplasm|signalosome				ovary(1)	1						CCGAGGGAGCGCCAAGATTTG	0.527000													14	30					0	0	1	0	0	
CD163L1	283316	broad.mit.edu	37	12	7531681	7531681	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:7531681G>A	uc001qsy.2	-	9	2290	c.2264C>T	c.(2263-2265)TCG>TTG	p.S755L	CD163L1_uc010sge.1_Missense_Mutation_p.S765L	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	755	SRCR 7.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GCCAGAATTCGACATTAAGAT	0.448000													34	63					0	0	1	0	0	
SLC2A3	6515	broad.mit.edu	37	12	8083109	8083109	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:8083109T>G	uc001qtr.2	-	5	902	c.640A>C	c.(640-642)ATT>CTT	p.I214L	SLC2A3_uc001qts.2_Missense_Mutation_p.I214L	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	214	Cytoplasmic (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		TTTCTGTTAATGAGCAAAAAT	0.423000													51	57					0	0	1	0	0	
LOC653113	653113	broad.mit.edu	37	12	8391292	8391292	+	RNA	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:8391292G>A	uc010sgk.1	-	2		c.249C>T				NR_024254				Homo sapiens family with sequence similarity 86, member A pseudogene (LOC653113), non-coding RNA.												0						AGAAAGCACCGGGCATACTTG	0.562000													12	52					0	0	1	0	0	
LOC653113	653113	broad.mit.edu	37	12	8391338	8391338	+	RNA	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:8391338T>C	uc010sgk.1	-	2		c.203A>G				NR_024254				Homo sapiens family with sequence similarity 86, member A pseudogene (LOC653113), non-coding RNA.												0						CACAGGATGCTTCACAGTCTA	0.527000													17	49					0	0	1	0	0	
PHC1	1911	broad.mit.edu	37	12	9089850	9089850	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:9089850C>T	uc001qvd.2	+	13	2712	c.2556C>T	c.(2554-2556)CGC>CGT	p.R852R	PHC1_uc001qve.2_Silent_p.R852R	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	852					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						ACTATGCTCGCGTTCGCAGGC	0.537000													7	17					0	0	1	0	0	
PZP	5858	broad.mit.edu	37	12	9345170	9345170	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:9345170C>T	uc001qvl.2	-	12	1449	c.1420G>A	c.(1420-1422)GCA>ACA	p.A474T	PZP_uc009zgl.2_Missense_Mutation_p.A343T	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GTATAGTGTGCCGTGATAGTC	0.488000													9	82					0	0	1	0	0	
CLEC2D	29121	broad.mit.edu	37	12	9847461	9847461	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:9847461A>G	uc001qwg.1	+	5	589	c.567A>G	c.(565-567)ATA>ATG	p.I189M	CLEC2D_uc001qwf.1_3'UTR|CLEC2D_uc009zgs.1_RNA|CLEC2D_uc001qwh.1_RNA|CLEC2D_uc009zgt.1_RNA|CLEC2D_uc009zgu.1_3'UTR	NM_013269	NP_037401	Q9UHP7	CLC2D_HUMAN	osteoclast inhibitory lectin isoform 1	189	Extracellular (Potential).				cell surface receptor linked signaling pathway	cell surface|endoplasmic reticulum|integral to plasma membrane|membrane fraction	sugar binding|transmembrane receptor activity				0						AATCAGATATACATGTCTAGA	0.333000													11	21					0	0	1	0	0	
GRIN2B	2904	broad.mit.edu	37	12	13717474	13717474	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:13717474G>A	uc001rbt.2	-	13	2877	c.2698C>T	c.(2698-2700)CGC>TGC	p.R900C		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	900	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGCAGCAGGCGCAGGATGTTG	0.582000													72	128					0	0	1	0	0	
PLEKHA5	54477	broad.mit.edu	37	12	19418767	19418767	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:19418767C>T	uc001reb.2	+	8	780	c.694C>T	c.(694-696)CGC>TGC	p.R232C	PLEKHA5_uc010sie.1_Missense_Mutation_p.R232C|PLEKHA5_uc001rea.2_Missense_Mutation_p.R232C|PLEKHA5_uc009zin.2_5'UTR|PLEKHA5_uc010sif.1_Missense_Mutation_p.R124C|PLEKHA5_uc010sig.1_Missense_Mutation_p.R124C|PLEKHA5_uc010sih.1_Missense_Mutation_p.R124C	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	232	PH.						1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					TCACATTAATCGCAAATATGC	0.328000													28	63					0	0	1	0	0	
PDE3A	5139	broad.mit.edu	37	12	20523104	20523104	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:20523104G>A	uc001reh.1	+	1	908	c.886G>A	c.(886-888)GTG>ATG	p.V296M		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	296					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CAGCTCCGTCGTGTCCGCCGA	0.622000													21	32					0	0	1	0	0	
SLCO1C1	53919	broad.mit.edu	37	12	20874789	20874789	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:20874789T>G	uc001rej.3	+	9	1182	c.827T>G	c.(826-828)CTT>CGT	p.L276R	SLCO1C1_uc010sii.1_Missense_Mutation_p.L276R|SLCO1C1_uc010sij.1_Missense_Mutation_p.L227R|SLCO1C1_uc009zip.2_Missense_Mutation_p.L110R|SLCO1C1_uc001rei.2_Missense_Mutation_p.L276R|SLCO1C1_uc010sik.1_Missense_Mutation_p.L158R	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	276	Helical; Name=6; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					GCCTGGTGGCTTGGCTATCTA	0.423000													15	31					0	0	1	0	0	
SLCO1B3	28234	broad.mit.edu	37	12	21229432	21229432	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:21229432G>A	uc010sil.1	+	15	2042	c.1977G>A	c.(1975-1977)ACG>ACA	p.T659T	LST-3TM12_uc010sim.1_Silent_p.T598T|LST-3TM12_uc010sin.1_Silent_p.T551T			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TTGATACAACGTGTATGAAGT	0.358000													56	119					0	0	1	0	0	
SLCO1A2	6579	broad.mit.edu	37	12	21453486	21453486	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:21453486G>A	uc001rer.2	-	7	957	c.706C>T	c.(706-708)CCC>TCC	p.P236S	SLCO1A2_uc001res.2_Missense_Mutation_p.P236S|SLCO1A2_uc010siq.1_Missense_Mutation_p.P104S|SLCO1A2_uc010sio.1_Missense_Mutation_p.P104S|SLCO1A2_uc010sip.1_Missense_Mutation_p.P104S|SLCO1A2_uc001ret.2_Missense_Mutation_p.P234S|SLCO1A2_uc001reu.2_Missense_Mutation_p.P216S	NM_021094	NP_066580	P46721	SO1A2_HUMAN	organic anion transporting polypeptide A	236	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GTGTCAGTGGGAGTTATGATC	0.363000													12	17					0	0	1	0	0	
ST8SIA1	6489	broad.mit.edu	37	12	22408261	22408261	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:22408261C>A	uc001rfo.3	-	3	926	c.444G>T	c.(442-444)AAG>AAT	p.K148N	ST8SIA1_uc009zix.2_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	148	Lumenal (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						AGCCACTCTTCTTCAGAATCC	0.522000													50	87					4.83215e-14	5.10571e-14	1	1	0	
ST8SIA1	6489	broad.mit.edu	37	12	22487107	22487107	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:22487107C>T	uc001rfo.3	-	1	542	c.60G>A	c.(58-60)GCG>GCA	p.A20A	ST8SIA1_uc009zix.2_Translation_Start_Site|uc001rfp.1_Intron	NM_003034	NP_003025	Q92185	SIA8A_HUMAN	alpha-2,8-sialyltransferase 1	20	Cytoplasmic (Potential).				glycosphingolipid biosynthetic process|protein glycosylation	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(3)	3						GGAACTTCCACGCCAGTACAG	0.716000													44	58					0	0	1	0	0	
KRAS	3845	broad.mit.edu	37	12	25398281	25398281	+	Missense_Mutation	SNP	C	T	T	rs112445441		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:25398281C>T	uc001rgp.1	-	2	219	c.38G>A	c.(37-39)GGC>GAC	p.G13D	KRAS_uc001rgq.1_Missense_Mutation_p.G13D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	13	GTP.		G -> R (in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway).|G -> D (in a breast carcinoma cell line and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G13D(2647)|p.G13C(182)|p.G13S(58)|p.G13R(41)|p.G13V(27)|p.G13A(24)|p.G13G(11)|p.G13E(4)|p.G12_G13insG(4)|p.G13N(3)|p.G13I(1)|p.G13_V14>DI(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CTTGCCTACGCCACCAGCTCC	0.338000	G13D(NCIH647_LUNG)|G13D(MDAMB231_BREAST)|G13D(NCIH747_LARGE_INTESTINE)|G13D(T84_LARGE_INTESTINE)|G13D(LOVO_LARGE_INTESTINE)|G13D(DLD1_LARGE_INTESTINE)|G13D(DV90_LUNG)|G13D(HCT15_LARGE_INTESTINE)|G13D(HCT116_LARGE_INTESTINE)|G13D(TOLEDO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G13D(NOMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			11	14					0	0	1	0	0	
C12orf71	728858	broad.mit.edu	37	12	27235392	27235392	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:27235392C>T	uc001rhq.2	-	1	64	c.25G>A	c.(25-27)GAC>AAC	p.D9N		NM_001080406	NP_001073875	A8MTZ7	CL071_HUMAN	hypothetical protein LOC728858	9											0						TCCTCTATGTCGCTGTTAGAG	0.463000													11	16					0	0	1	0	0	
FAR2	55711	broad.mit.edu	37	12	29486714	29486714	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:29486714C>T	uc001ris.3	+	12	1682	c.1535C>T	c.(1534-1536)ACG>ATG	p.T512M	FAR2_uc001rit.2_Missense_Mutation_p.T512M|FAR2_uc009zjm.2_Missense_Mutation_p.T415M	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	512					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						GCATCCAGCACGCTCAAAGTT	0.408000													33	45					0	0	1	0	0	
OVCH1	341350	broad.mit.edu	37	12	29639191	29639191	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:29639191C>A	uc001rix.1	-	8	983	c.983G>T	c.(982-984)AGA>ATA	p.R328I		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	328	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					ACCCTTTCCTCTCTGGCTTCC	0.448000													37	37					1.48734e-19	1.59037e-19	1	1	0	
KIF21A	55605	broad.mit.edu	37	12	39752103	39752103	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:39752103G>A	uc001rly.2	-	8	1238	c.1092C>T	c.(1090-1092)TAC>TAT	p.Y364Y	KIF21A_uc001rlx.2_Silent_p.Y364Y|KIF21A_uc001rlz.2_Silent_p.Y364Y|KIF21A_uc010skl.1_Silent_p.Y364Y|KIF21A_uc001rma.1_Silent_p.Y372Y	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	364					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CTCGATTGGCGTATTTCAGGG	0.398000													63	112					0	0	1	0	0	
LRRK2	120892	broad.mit.edu	37	12	40740562	40740562	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:40740562T>C	uc001rmg.3	+	42	6238	c.6117T>C	c.(6115-6117)CGT>CGC	p.R2039R	LRRK2_uc009zjw.2_Silent_p.R877R|LRRK2_uc001rmi.2_Silent_p.R872R	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2039	Protein kinase.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				CAGGGTTTCGTGCACCTGAAG	0.373000													9	30					0	0	1	0	0	
CNTN1	1272	broad.mit.edu	37	12	41374776	41374776	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:41374776T>C	uc001rmm.1	+	16	1983	c.1870T>C	c.(1870-1872)TGG>CGG	p.W624R	CNTN1_uc001rmn.1_Missense_Mutation_p.W613R	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	624	Fibronectin type-III 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GGCACTTACTTGGAGCCGTGG	0.433000													59	65					0	0	1	0	0	
RAPGEF3	10411	broad.mit.edu	37	12	48134142	48134142	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:48134142G>A	uc009zkp.2	-	21	2582	c.2142C>T	c.(2140-2142)GCC>GCT	p.A714A	uc001rpv.2_RNA|RAPGEF3_uc001rpw.2_Silent_p.A49A|RAPGEF3_uc001rpx.2_Silent_p.A171A|RAPGEF3_uc010sln.1_Intron|RAPGEF3_uc001rpy.2_RNA|RAPGEF3_uc009zkq.2_Silent_p.A714A|RAPGEF3_uc001rpz.3_Silent_p.A756A	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	714					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		CAAACATGACGGCAAAGAAGG	0.607000													22	48					0	0	1	0	0	
CCNT1	904	broad.mit.edu	37	12	49110342	49110342	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:49110342C>T	uc001rse.1	-	1	440	c.117G>A	c.(115-117)CAG>CAA	p.Q39Q	CCNT1_uc009zkz.1_5'UTR	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	39					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						TGGCCGCCTGCTGGCGATAAG	0.537000											OREG0021767	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	94					0	0	1	0	0	
ADCY6	112	broad.mit.edu	37	12	49177014	49177014	+	Silent	SNP	G	A	A	rs147362088		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:49177014G>A	uc001rsh.3	-	1	864	c.204C>T	c.(202-204)GAC>GAT	p.D68D	ADCY6_uc001rsj.3_Silent_p.D68D|ADCY6_uc001rsi.3_Silent_p.D68D	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	68	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						GGATGAAGGCGTCATCCTGCC	0.711000													13	31					0	0	1	0	0	
CACNB3	784	broad.mit.edu	37	12	49221650	49221650	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:49221650C>T	uc001rsl.1	+	13	1624	c.1423C>T	c.(1423-1425)CGC>TGC	p.R475C	CACNB3_uc010sly.1_Missense_Mutation_p.R462C|CACNB3_uc010slz.1_Missense_Mutation_p.R474C|CACNB3_uc001rsk.1_Missense_Mutation_p.R322C	NM_000725	NP_000716	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3	475					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0					Verapamil(DB00661)	GAACTGGCAGCGCAACCGGCC	0.657000													13	34					0	0	1	0	0	
KCNH3	23416	broad.mit.edu	37	12	49938099	49938099	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:49938099G>A	uc001ruh.1	+	7	1383	c.1123G>A	c.(1123-1125)GCC>ACC	p.A375T	KCNH3_uc010smj.1_Missense_Mutation_p.A315T	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	375	Helical; Name=Segment S5; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						GCACTGGGTCGCCTGCGTCTG	0.592000													5	10					0	0	1	0	0	
ACVR1B	91	broad.mit.edu	37	12	52374774	52374774	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:52374774G>A	uc001rzn.2	+	4	644	c.602G>A	c.(601-603)CGC>CAC	p.R201H	ACVR1B_uc001rzl.2_Missense_Mutation_p.R201H|ACVR1B_uc001rzm.2_Missense_Mutation_p.R201H|ACVR1B_uc010snn.1_Missense_Mutation_p.R201H	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	201	Cytoplasmic (Potential).|GS.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	TTTGTCCAGCGCACAGTGGCC	0.498000											OREG0021829	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	40					0	0	1	0	0	
KRT86	3892	broad.mit.edu	37	12	52695798	52695798	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:52695798G>A	uc010snq.1	+	2	231	c.98G>A	c.(97-99)CGT>CAT	p.R33H	KRT86_uc009zmg.2_Missense_Mutation_p.R33H|KRT81_uc001sac.2_Intron|KRT86_uc001sad.2_Missense_Mutation_p.R33H	NM_002284	NP_002275	O43790	KRT86_HUMAN	keratin 86	33	Head.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCCCCTACCGTGGCATCTCC	0.711000													26	23					0	0	1	0	0	
KRT6B	3854	broad.mit.edu	37	12	52845339	52845339	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:52845339G>A	uc001sak.2	-	1	572	c.524C>T	c.(523-525)GCC>GTC	p.A175V		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	175	Coil 1A.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		GATGAAGGAGGCAAACTTGTT	0.602000													22	115					0	0	1	0	0	
KRT6A	3853	broad.mit.edu	37	12	52886449	52886449	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:52886449G>A	uc001sam.2	-	1	733	c.524C>T	c.(523-525)GCC>GTC	p.A175V		NM_005554	NP_005545	P02538	K2C6A_HUMAN	keratin 6A	175	Coil 1A.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			ovary(4)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.189)		GATGAAGGAGGCAAACTTGTT	0.587000													8	157					0	0	1	0	0	
KRT73	319101	broad.mit.edu	37	12	53002213	53002213	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:53002213C>T	uc001sas.2	-	9	1425	c.1390G>A	c.(1390-1392)GGG>AGG	p.G464R		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	464	Tail.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCTGCCATCCCGGCCATGGAG	0.622000													13	25					0	0	1	0	0	
KRT4	3851	broad.mit.edu	37	12	53207430	53207430	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:53207430C>T	uc001saz.2	-	1	906	c.635G>A	c.(634-636)CGC>CAC	p.R212H		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	138						keratin filament	structural molecule activity	p.R212R(1)		ovary(4)|skin(2)	6						GATCTGTTCGCGCTCTTCCGT	0.572000													83	94					0	0	1	0	0	
MAP3K12	7786	broad.mit.edu	37	12	53875972	53875972	+	Missense_Mutation	SNP	C	T	T	rs149876591		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:53875972C>T	uc001sdm.1	-	14	2332	c.2234G>A	c.(2233-2235)CGC>CAC	p.R745H	MAP3K12_uc001sdn.1_Missense_Mutation_p.R778H	NM_006301	NP_006292	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase	745					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			lung(2)|ovary(1)|breast(1)|skin(1)	5						TAGTGACTGGCGCATGTTCAG	0.512000											OREG0021873	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	139					0	0	1	0	0	
HOXC13	3229	broad.mit.edu	37	12	54338978	54338978	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:54338978C>T	uc001sei.2	+	2	1046	c.931C>T	c.(931-933)CGG>TGG	p.R311W	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	311	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GTTCCAGAACCGGCGGGTCAA	0.572000			T	NUP98	AML								27	47					0	0	1	0	0	
HOXC8	3224	broad.mit.edu	37	12	54403386	54403386	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:54403386G>A	uc001ser.2	+	1	497	c.318G>A	c.(316-318)GCG>GCA	p.A106A		NM_022658	NP_073149	P31273	HXC8_HUMAN	homeobox C8	106						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGCAAGAGGCGAGCGTGGTGC	0.547000													82	118					0	0	1	0	0	
PPP1R1A	5502	broad.mit.edu	37	12	54975883	54975883	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:54975883G>A	uc001sgg.2	-	5	451	c.280C>T	c.(280-282)CAA>TAA	p.Q94*		NM_006741	NP_006732	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	94					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity				0						TGCTGCTGTTGCCCCAGGTGA	0.602000													16	17					0	0	1	0	0	
IKZF4	64375	broad.mit.edu	37	12	56415292	56415292	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:56415292C>T	uc001sjb.1	+	2	174	c.15C>T	c.(13-15)CCC>CCT	p.P5P	IKZF4_uc010sqa.1_Intron|IKZF4_uc001sjc.1_Silent_p.P5P|IKZF4_uc001sjd.1_5'UTR|IKZF4_uc009zoi.1_Intron	NM_022465	NP_071910	Q9H2S9	IKZF4_HUMAN	zinc finger protein, subfamily 1A, 4	5					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			ATACACCACCCGCACTCCCTC	0.632000													4	8					0	0	1	0	0	
ERBB3	2065	broad.mit.edu	37	12	56481671	56481671	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:56481671T>C	uc001sjh.2	+	6	899	c.706T>C	c.(706-708)TCA>CCA	p.S236P	ERBB3_uc009zoj.2_RNA|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.S177P|ERBB3_uc001sji.2_5'Flank	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	236	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CGGGGGCTGCTCAGGCCCTCA	0.547000													55	105					0	0	1	0	0	
ERBB3	2065	broad.mit.edu	37	12	56487604	56487604	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:56487604G>T	uc001sjh.2	+	13	1730	c.1537G>T	c.(1537-1539)GGC>TGC	p.G513C	ERBB3_uc009zoj.2_Intron|ERBB3_uc010sqb.1_Intron|ERBB3_uc010sqc.1_Missense_Mutation_p.G454C|ERBB3_uc009zok.2_Translation_Start_Site|ERBB3_uc001sjk.2_5'Flank|ERBB3_uc001sjj.1_Missense_Mutation_p.G81C	NM_001982	NP_001973	P21860	ERBB3_HUMAN	erbB-3 isoform 1 precursor	513	Extracellular (Potential).				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(3)|central_nervous_system(2)|stomach(1)|ovary(1)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CTGGGGCCCAGGCCCTGGTCA	0.577000													38	81					1.49673e-21	1.60375e-21	1	1	0	
PAN2	9924	broad.mit.edu	37	12	56720737	56720737	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:56720737C>T	uc001skx.2	-	7	1299	c.926G>A	c.(925-927)TGC>TAC	p.C309Y	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.C309Y|PAN2_uc001sky.2_Missense_Mutation_p.C309Y	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	309					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						ACAGAATTGGCACTGCCCTAC	0.502000													21	44					0	0	1	0	0	
RBMS2	5939	broad.mit.edu	37	12	56962790	56962790	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:56962790C>T	uc001sln.2	+	3	464	c.265C>T	c.(265-267)CTG>TTG	p.L89L	RBMS2_uc010sqp.1_5'UTR|RBMS2_uc010sqq.1_5'UTR|RBMS2_uc009zou.2_Intron	NM_002898	NP_002889	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting	89	RRM 1.				RNA processing	nucleus	nucleotide binding|RNA binding				0						TAAGGCCATACTGGACAAGAC	0.453000													14	30					0	0	1	0	0	
GPR182	11318	broad.mit.edu	37	12	57389547	57389547	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57389547C>T	uc001smk.2	+	2	648	c.554C>T	c.(553-555)CCG>CTG	p.P185L	RDH16_uc010sqx.1_Intron	NM_007264	NP_009195	O15218	GP182_HUMAN	G protein-coupled receptor 182	185	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(1)	1						GCCATCATCCCGCTGCCTGAG	0.647000													21	48					0	0	1	0	0	
NAB2	4665	broad.mit.edu	37	12	57485188	57485188	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57485188G>A	uc001smz.2	+	2	742	c.364G>A	c.(364-366)GTC>ATC	p.V122I		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	122					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TGCTGTTCCCGTCTCCAGCAT	0.617000													36	73					0	0	1	0	0	
STAT6	6778	broad.mit.edu	37	12	57499332	57499332	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57499332G>A	uc009zpe.2	-	8	982	c.731C>T	c.(730-732)GCG>GTG	p.A244V	STAT6_uc009zpf.2_Missense_Mutation_p.A244V|STAT6_uc001sna.2_Missense_Mutation_p.A244V|STAT6_uc010srb.1_Missense_Mutation_p.A134V|STAT6_uc010src.1_Missense_Mutation_p.A134V|STAT6_uc010srd.1_Missense_Mutation_p.A134V|STAT6_uc009zpg.2_Missense_Mutation_p.A293V	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	244					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						CCCACCAGCCGCCCCTACCTC	0.627000													11	20					0	0	1	0	0	
MBD6	114785	broad.mit.edu	37	12	57919830	57919830	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57919830G>A	uc001soj.1	+	6	1303	c.1079G>A	c.(1078-1080)CGT>CAT	p.R360H	MBD6_uc001sok.1_Missense_Mutation_p.R227H|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	360	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						TCATCACTTCGTCCCTCTCAG	0.647000													36	35					0	0	1	0	0	
MBD6	114785	broad.mit.edu	37	12	57922092	57922092	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57922092C>T	uc001soj.1	+	10	2793	c.2569C>T	c.(2569-2571)CGG>TGG	p.R857W	MBD6_uc001sok.1_Missense_Mutation_p.R725W|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	857						chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						GTCAGGGAAACGGGGCCGGAG	0.706000													10	19					0	0	1	0	0	
AVIL	10677	broad.mit.edu	37	12	58203443	58203443	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:58203443G>T	uc001sqj.1	-	8	905	c.876C>A	c.(874-876)ATC>ATA	p.I292I	AVIL_uc009zqe.1_Silent_p.I285I|AVIL_uc001sqk.1_5'Flank|AVIL_uc001sql.3_Silent_p.I269I	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	292	Gelsolin-like 3.|Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					TCCACACGTAGATTTTGGTTC	0.458000													29	47					5.6714e-07	5.81298e-07	1	1	0	
AVIL	10677	broad.mit.edu	37	12	58207051	58207051	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:58207051A>G	uc001sqj.1	-	3	326	c.297T>C	c.(295-297)CAT>CAC	p.H99H	AVIL_uc009zqe.1_Silent_p.H92H|AVIL_uc001sql.3_Silent_p.H76H	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	99	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					TGTCTGACTCATGGTACTGGA	0.463000													52	76					0	0	1	0	0	
MSRB3	253827	broad.mit.edu	37	12	65762800	65762800	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:65762800G>A	uc001ssn.2	+	4	368	c.307G>A	c.(307-309)GGT>AGT	p.G103S	MSRB3_uc001ssm.2_Missense_Mutation_p.G96S|MSRB3_uc009zqp.2_Missense_Mutation_p.G96S	NM_198080	NP_932346	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3 isoform 1	103					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		ATTTGACTCCGGTTCAGGTAT	0.318000													15	24					0	0	1	0	0	
NUP107	57122	broad.mit.edu	37	12	69113183	69113183	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:69113183A>G	uc001suf.2	+	13	1261	c.1146A>G	c.(1144-1146)AAA>AAG	p.K382K	NUP107_uc001sug.2_Silent_p.K229K|NUP107_uc010stj.1_Silent_p.K353K	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	382					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AAGGCTGGAAACTGTACCATG	0.418000													18	43					0	0	1	0	0	
ZFC3H1	196441	broad.mit.edu	37	12	72013181	72013181	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:72013181G>A	uc001swo.2	-	27	5417	c.5058C>T	c.(5056-5058)GGC>GGT	p.G1686G		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1686					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						GAAGATTATCGCCTCGATTCT	0.343000													20	24					0	0	1	0	0	
TPH2	121278	broad.mit.edu	37	12	72425063	72425063	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:72425063T>C	uc009zrw.1	+	10	1331	c.1190T>C	c.(1189-1191)GTG>GCG	p.V397A	TPH2_uc001swy.2_Missense_Mutation_p.V307A	NM_173353	NP_775489	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	397					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			ovary(2)|central_nervous_system(1)|skin(1)	4					L-Tryptophan(DB00150)	AAGGCATGTGTGAAAGCCTTT	0.413000													51	59					0	0	1	0	0	
TRHDE	29953	broad.mit.edu	37	12	73014965	73014965	+	Silent	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:73014965T>A	uc001sxa.2	+	14	2442	c.2412T>A	c.(2410-2412)GTT>GTA	p.V804V		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	804	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GATCTCTTGTTCAAGCATCCT	0.333000													16	54					0	0	1	0	0	
PPFIA2	8499	broad.mit.edu	37	12	81661753	81661753	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:81661753C>T	uc001szo.1	-	29	3585	c.3424G>A	c.(3424-3426)GAT>AAT	p.D1142N	PPFIA2_uc010sue.1_Intron|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA|PPFIA2_uc010suf.1_RNA|PPFIA2_uc009zsh.2_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	1041										ovary(3)|lung(2)|pancreas(1)	6						AAGTTTTCATCCAGGGCTATA	0.423000													4	4					0	0	1	0	0	
ALX1	8092	broad.mit.edu	37	12	85674140	85674140	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:85674140C>T	uc001tae.3	+	1	105	c.101C>T	c.(100-102)ACG>ATG	p.T34M		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	34					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		GTTATGGAGACGCTGGACAAT	0.567000													34	61					0	0	1	0	0	
LUM	4060	broad.mit.edu	37	12	91497971	91497971	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:91497971G>A	uc001tbm.2	-	3	1377	c.988C>T	c.(988-990)CGT>TGT	p.R330C	LUM_uc001tbn.2_RNA	NM_002345	NP_002336	P51884	LUM_HUMAN	lumican precursor	330					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)	2						TTAGCAACACGTAGACATTCA	0.383000													24	55					0	0	1	0	0	
EEA1	8411	broad.mit.edu	37	12	93206754	93206754	+	Splice_Site	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:93206754A>G	uc001tck.2	-	16	2308	c.2043_splice	c.e16+1	p.Q681_splice		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD						early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						CTGTTTCCCTACCTGCTGTTT	0.353000													26	46					0	0	1	0	0	
ELK3	2004	broad.mit.edu	37	12	96641143	96641143	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:96641143C>T	uc001teo.1	+	3	912	c.633C>T	c.(631-633)TCC>TCT	p.S211S		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	211	Poly-Ala.				negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CGGCGGCGTCCGCCTTCCTGG	0.582000													45	60					0	0	1	0	0	
UTP20	27340	broad.mit.edu	37	12	101736357	101736357	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:101736357C>T	uc001tia.1	+	33	4391	c.4235C>T	c.(4234-4236)ACG>ATG	p.T1412M		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	1412					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						TTGCTTTGTACGGTTTTTGAG	0.338000													13	13					0	0	1	0	0	
STAB2	55576	broad.mit.edu	37	12	104139055	104139055	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:104139055G>T	uc001tjw.2	+	57	6322	c.6136G>T	c.(6136-6138)GTT>TTT	p.V2046F	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2046	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CACTCAGGCAGGTCAGTCATG	0.597000													9	15					3.09899e-07	3.18111e-07	1	1	0	
NUAK1	9891	broad.mit.edu	37	12	106461103	106461103	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:106461103G>A	uc001tlj.1	-	7	2843	c.1463C>T	c.(1462-1464)TCG>TTG	p.S488L		NM_014840	NP_055655	O60285	NUAK1_HUMAN	AMPK-related protein kinase 5	488							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|central_nervous_system(1)	2						CAACAGCTCCGAAGACTCACT	0.597000													28	54					0	0	1	0	0	
RIC8B	55188	broad.mit.edu	37	12	107237716	107237716	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:107237716C>T	uc001tlx.2	+	6	1277	c.1152C>T	c.(1150-1152)CTC>CTT	p.L384L	RIC8B_uc001tlw.2_Silent_p.L384L|RIC8B_uc001tly.2_Silent_p.L344L|RIC8B_uc001tlz.2_RNA|RIC8B_uc009zur.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	384					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						GAAAATTTCTCAAAGATCAGG	0.333000													25	47					0	0	1	0	0	
FICD	11153	broad.mit.edu	37	12	108910878	108910878	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:108910878G>A	uc001tmx.1	+	2	275	c.129G>A	c.(127-129)CCG>CCA	p.P43P		NM_007076	NP_009007	Q9BVA6	FICD_HUMAN	Huntingtin interacting protein E	43	Helical; (Potential).				negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity				0						TGCTGCTGCCGCTGGGGGCTG	0.652000													17	24					0	0	1	0	0	
MYO1H	283446	broad.mit.edu	37	12	109839056	109839056	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:109839056G>A	uc010sxn.1	+	5	681	c.681G>A	c.(679-681)CAG>CAA	p.Q227Q		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						GAGACCCCCAGCTGTATAAAT	0.552000													11	16					0	0	1	0	0	
ATXN2	6311	broad.mit.edu	37	12	111908405	111908405	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:111908405G>T	uc001tsj.2	-	19	3302	c.3140C>A	c.(3139-3141)CCA>CAA	p.P1047Q	ATXN2_uc001tsh.2_Missense_Mutation_p.P782Q|ATXN2_uc001tsi.2_Missense_Mutation_p.P758Q|ATXN2_uc001tsk.2_RNA|ATXN2_uc001tsg.2_Missense_Mutation_p.P235Q|ATXN2_uc001tsl.1_Missense_Mutation_p.P66Q	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	1047	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						GGGCTGATTTGGGAACTGCTG	0.483000													37	68					6.48837e-15	6.87338e-15	1	1	0	
RPH3A	22895	broad.mit.edu	37	12	113328777	113328777	+	Missense_Mutation	SNP	G	A	A	rs140115309		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:113328777G>A	uc010syl.1	+	19	2106	c.1744G>A	c.(1744-1746)GCT>ACT	p.A582T	RPH3A_uc001ttz.2_Missense_Mutation_p.A582T|RPH3A_uc001tty.2_Missense_Mutation_p.A578T|RPH3A_uc009zwe.1_Missense_Mutation_p.A577T|RPH3A_uc010sym.1_Missense_Mutation_p.A533T|RPH3A_uc001tua.2_Missense_Mutation_p.A342T	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	582	C2 2.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TGCCATGGACGCTAATGGCTA	0.577000													13	20					0	0	1	0	0	
DTX1	1840	broad.mit.edu	37	12	113515236	113515236	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:113515236G>A	uc001tuk.1	+	2	603	c.267G>A	c.(265-267)ATG>ATA	p.M89I		NM_004416	NP_004407	Q86Y01	DTX1_HUMAN	deltex homolog 1	89	WWE 1.				negative regulation of neuron differentiation|Notch signaling pathway|regulation of Notch signaling pathway|transcription from RNA polymerase II promoter	cytoplasm|nucleus	Notch binding|SH3 domain binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4						CAGGCACCATGCGGCCCGTGC	0.697000													20	30					0	0	1	0	0	
DDX54	79039	broad.mit.edu	37	12	113601049	113601049	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:113601049G>A	uc001tup.2	-	16	1997	c.1969C>T	c.(1969-1971)CGG>TGG	p.R657W	DDX54_uc001tuq.3_Missense_Mutation_p.R657W	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	657					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						GACCGCTGCCGCTTCCGGCCC	0.652000													28	28					0	0	1	0	0	
DDX54	79039	broad.mit.edu	37	12	113603823	113603823	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:113603823C>A	uc001tup.2	-	13	1457	c.1429G>T	c.(1429-1431)GAT>TAT	p.D477Y	DDX54_uc001tuq.3_Missense_Mutation_p.D477Y	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	477					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						AGCATGCCATCCACACCGGCC	0.667000													13	38					5.50884e-06	5.62949e-06	1	1	0	
IQCD	115811	broad.mit.edu	37	12	113645772	113645772	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:113645772G>A	uc001tuv.1	-	2	622	c.200C>T	c.(199-201)ACC>ATC	p.T67I	IQCD_uc001tuu.2_Missense_Mutation_p.T67I	NM_138451	NP_612460	Q96DY2	IQCD_HUMAN	IQ motif containing D	67										ovary(1)	1						CGACAGCAAGGTCACCAGCTC	0.537000													72	112					0	0	1	0	0	
MAP1LC3B2	643246	broad.mit.edu	37	12	117013778	117013778	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:117013778C>T	uc009zwk.1	+	2	185	c.31C>T	c.(31-33)CGC>TGC	p.R11C		NM_001085481	NP_001078950	A6NCE7	MP3B2_HUMAN	microtubule-associated protein 1 light chain 3	11					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule					0						CAAGCAGCGGCGCACCTTCGA	0.602000													56	54					0	0	1	0	0	
NOS1	4842	broad.mit.edu	37	12	117672561	117672561	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:117672561C>T	uc001twm.1	-	21	3730	c.3044G>A	c.(3043-3045)CGG>CAG	p.R1015Q		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1015	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GATAGTTGACCGACTGCAGGA	0.478000													7	9					0	0	1	0	0	
KSR2	283455	broad.mit.edu	37	12	118198971	118198971	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:118198971C>T	uc001two.2	-	4	799	c.744G>A	c.(742-744)CCG>CCA	p.P248P		NM_173598	NP_775869	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	277	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			lung(10)|central_nervous_system(2)|stomach(1)|large_intestine(1)|breast(1)	15	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCTCATGGGCGGCGTGCCCG	0.701000													96	148					0	0	1	0	0	
CCDC60	160777	broad.mit.edu	37	12	119916943	119916943	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:119916943C>T	uc001txe.2	+	4	851	c.386C>T	c.(385-387)ACA>ATA	p.T129I	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	129										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GCTAGAGTCACACGTCGCCCA	0.483000													19	30					0	0	1	0	0	
GCN1L1	10985	broad.mit.edu	37	12	120576636	120576636	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:120576636C>T	uc001txo.2	-	46	6032	c.6019G>A	c.(6019-6021)GTG>ATG	p.V2007M		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2007	HEAT 17.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCCGTGGGCACGAGGGATTCA	0.557000													53	109					0	0	1	0	0	
SPPL3	121665	broad.mit.edu	37	12	121229361	121229361	+	Splice_Site	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:121229361C>A	uc001tzd.2	-	3	583	c.102_splice	c.e3-1	p.R34_splice	SPPL3_uc009zwz.2_Splice_Site_p.R34_splice	NM_139015	NP_620584	Q8TCT6	PSL4_HUMAN	signal peptide peptidase 3							integral to membrane	aspartic-type endopeptidase activity				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATTAAGGGACCTGTGGAAAAA	0.313000													24	27					4.4004e-07	4.5125e-07	1	1	0	
RNF34	80196	broad.mit.edu	37	12	121868063	121868063	+	Silent	SNP	G	A	A	rs111862260	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:121868063G>A	uc001uam.1	+	7	1404	c.1290G>A	c.(1288-1290)CCG>CCA	p.P430P	KDM2B_uc001uaq.2_Intron|KDM2B_uc010szy.1_3'UTR|KDM2B_uc001uar.2_Intron|KDM2B_uc001uas.2_Intron|KDM2B_uc001uat.2_3'UTR|KDM2B_uc001uau.2_3'UTR|KDM2B_uc001uao.2_Intron|KDM2B_uc010szx.1_3'UTR|KDM2B_uc001uap.2_Intron	NM_025126	NP_079402	Q969K3	RNF34_HUMAN	ring finger protein 34 isoform 2	Error:Variant_position_missing_in_Q969K3_after_alignment					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		CCCAGAGCCCGCCCCGTATTT	0.443000													30	43					0	0	1	0	0	
HPD	3242	broad.mit.edu	37	12	122295334	122295334	+	Missense_Mutation	SNP	G	A	A	rs140596268		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:122295334G>A	uc001ubj.2	-	4	138	c.98C>T	c.(97-99)GCG>GTG	p.A33V	HPD_uc001ubk.2_Translation_Start_Site	NM_002150	NP_002141	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	33					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding				0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	GTAGAATGACGTGGCCTGAAT	0.607000													29	52					0	0	1	0	0	
WDR66	144406	broad.mit.edu	37	12	122439464	122439464	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:122439464C>T	uc009zxk.2	+	21	3439	c.3297C>T	c.(3295-3297)CCC>CCT	p.P1099P		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	1099							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GCCTGAATCCCGAGGGATGGA	0.498000													42	53					0	0	1	0	0	
GPR109B	8843	broad.mit.edu	37	12	123200619	123200619	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:123200619C>T	uc001ucy.3	-	1	821	c.666G>A	c.(664-666)CGG>CGA	p.R222R	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	222	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	TCTTGGCATGCCGGTCCATTT	0.537000													12	29					0	0	1	0	0	
GPR109B	8843	broad.mit.edu	37	12	123200736	123200736	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:123200736G>A	uc001ucy.3	-	1	704	c.549C>T	c.(547-549)TGC>TGT	p.C183C	GPR81_uc001ucw.1_Intron	NM_006018	NP_006009	P49019	HCAR3_HUMAN	G protein-coupled receptor 109B	183	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	GGAAGGTATGGCAGATGCTGA	0.537000													20	26					0	0	1	0	0	
HIP1R	9026	broad.mit.edu	37	12	123334437	123334437	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:123334437C>T	uc001udj.1	+	5	432	c.373C>T	c.(373-375)CGC>TGC	p.R125C	HIP1R_uc001udg.1_Missense_Mutation_p.R113C|HIP1R_uc001udi.1_Missense_Mutation_p.R125C|HIP1R_uc001udh.2_Missense_Mutation_p.R125C	NM_003959	NP_003950	O75146	HIP1R_HUMAN	huntingtin interacting protein-1-related	125	ENTH.				receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		TTTGCATGACCGCTACGGACA	0.587000													8	41					0	0	1	0	0	
PITPNM2	57605	broad.mit.edu	37	12	123472180	123472180	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:123472180C>T	uc001uej.1	-	21	3280	c.3141G>A	c.(3139-3141)CCG>CCA	p.P1047P	PITPNM2_uc001uek.1_Silent_p.P1041P	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	1047					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CGCCTGAGGGCGGCTGGGTCA	0.667000													14	30					0	0	1	0	0	
NCOR2	9612	broad.mit.edu	37	12	124826379	124826379	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:124826379C>T	uc010tba.1	-	34	5319	c.5202G>A	c.(5200-5202)GCG>GCA	p.A1734A	NCOR2_uc010tay.1_Silent_p.A1733A|NCOR2_uc010taz.1_Silent_p.A1717A|NCOR2_uc010tbb.1_Silent_p.A1726A|NCOR2_uc010tbc.1_Silent_p.A1716A|NCOR2_uc010tax.1_5'Flank	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	1734					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CTCGGGGACCCGCAGCGTAGT	0.667000													38	48					0	0	1	0	0	
FZD10	11211	broad.mit.edu	37	12	130647705	130647705	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:130647705C>T	uc001uii.2	+	1	674	c.218C>T	c.(217-219)CCG>CTG	p.P73L	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	73	FZ.|Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GAGTTCGCGCCGCTGGTGGAG	0.642000													8	60					0	0	1	0	0	
RIMBP2	23504	broad.mit.edu	37	12	130926898	130926898	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:130926898G>A	uc001uil.2	-	8	1112	c.948C>T	c.(946-948)GGC>GGT	p.G316G	RIMBP2_uc001uim.2_Silent_p.G224G|RIMBP2_uc001uin.1_5'UTR	NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	316	Fibronectin type-III 1.					cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGGGCTCCCAGCCCACAATAA	0.567000													58	104					0	0	1	0	0	
EP400	57634	broad.mit.edu	37	12	132445535	132445535	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:132445535C>T	uc001ujn.2	+	1	406	c.371C>T	c.(370-372)ACG>ATG	p.T124M	EP400_uc001ujl.2_Missense_Mutation_p.T124M|EP400_uc001ujm.2_Missense_Mutation_p.T124M|EP400_uc001ujj.1_Missense_Mutation_p.T124M|EP400_uc001ujk.2_Missense_Mutation_p.T124M	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	124					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		ATTCAGGTCACGTCCCCCTTG	0.672000													9	10					0	0	1	0	0	
EP400NL	347918	broad.mit.edu	37	12	132589446	132589446	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:132589446C>A	uc001ujv.2	+	1	905	c.881C>A	c.(880-882)GCT>GAT	p.A294D	EP400NL_uc001ujr.2_Missense_Mutation_p.A162D|EP400NL_uc001ujs.3_Missense_Mutation_p.A225D|EP400NL_uc009zyq.2_Missense_Mutation_p.A162D|EP400NL_uc001ujt.2_Missense_Mutation_p.A162D|EP400NL_uc001ujw.1_Translation_Start_Site					RecName: Full=EP400 N-terminal-like protein;												0						CTCCCCGGGGCTGGGGGCGCA	0.736000													3	0					0.00909568	0.00915813	1	1	0	
GOLGA3	2802	broad.mit.edu	37	12	133362988	133362988	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:133362988C>T	uc001ukz.1	-	15	3619	c.3060G>A	c.(3058-3060)GCG>GCA	p.A1020A	GOLGA3_uc001ula.1_Silent_p.A1020A|GOLGA3_uc001ulb.2_Silent_p.A1020A	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1020	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTCCGCGTCCGCAGCCTCCT	0.667000													13	21					0	0	1	0	0	
LOC284232	284232	broad.mit.edu	37	13	19433058	19433058	+	RNA	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:19433058T>C	uc010tcj.1	-	1		c.13052A>G				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						GTTGATTTCTTTACAATTTTT	0.348000													4	38					0	0	1	0	0	
MPHOSPH8	54737	broad.mit.edu	37	13	20235838	20235838	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:20235838G>A	uc001umh.2	+	8	1801	c.1792G>A	c.(1792-1794)GAT>AAT	p.D598N	MPHOSPH8_uc001umg.2_Missense_Mutation_p.D598N	NM_017520	NP_059990	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	598					cell cycle	cytoplasm|nucleus					0		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		ACCAACACAGGATTCCAGTGG	0.463000													65	113					0	0	1	0	0	
SACS	26278	broad.mit.edu	37	13	23905080	23905080	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:23905080G>T	uc001uon.2	-	10	13524	c.12935C>A	c.(12934-12936)TCT>TAT	p.S4312Y	SACS_uc001uoo.2_Missense_Mutation_p.S4165Y|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4312	J.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTCCACCACAGATGTCACTTC	0.403000													58	105					2.3441e-25	2.52621e-25	1	1	0	
C1QTNF9	338872	broad.mit.edu	37	13	24892996	24892996	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:24892996G>A	uc001upj.2	+	3	268	c.207G>A	c.(205-207)ACG>ACA	p.T69T	C1QTNF9_uc001upe.2_RNA	NM_178540	NP_848635	P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	69	Collagen-like 1.					collagen	hormone activity				0		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		AGGATGGGACGAGTGGAGAGA	0.463000													24	49					0	0	1	0	0	
PARP4	143	broad.mit.edu	37	13	25030482	25030482	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:25030482G>A	uc001upl.2	-	21	2665	c.2559C>T	c.(2557-2559)AGC>AGT	p.S853S	PARP4_uc010tdc.1_Silent_p.S853S	NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	853					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AGTATACCTCGCTTTCTTTTT	0.383000													18	49					0	0	1	0	0	
FAM123A	219287	broad.mit.edu	37	13	25745243	25745243	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:25745243C>T	uc001uqb.2	-	1	615	c.515G>A	c.(514-516)CGC>CAC	p.R172H	FAM123A_uc001uqa.2_Missense_Mutation_p.R172H|FAM123A_uc001uqc.2_Missense_Mutation_p.R172H	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	172										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		GTTTTCCGAGCGCCCGTTCTT	0.706000													5	38					0	0	1	0	0	
ATP8A2	51761	broad.mit.edu	37	13	26117431	26117431	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:26117431T>C	uc001uqk.2	+	10	924	c.782T>C	c.(781-783)CTT>CCT	p.L261P	ATP8A2_uc010tdi.1_Missense_Mutation_p.L221P|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.L221P	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	221	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ATTTTTAGCCTTGTTGCCCTT	0.363000													30	57					0	0	1	0	0	
ATP8A2	51761	broad.mit.edu	37	13	26153014	26153014	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:26153014A>C	uc001uqk.2	+	21	1986	c.1844A>C	c.(1843-1845)CAT>CCT	p.H615P	ATP8A2_uc010tdi.1_Missense_Mutation_p.H575P|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.H125P	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	575	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ACATTATGCCATCTGGAATAC	0.388000													16	37					0	0	1	0	0	
GPR12	2835	broad.mit.edu	37	13	27332975	27332975	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:27332975C>T	uc010aal.2	-	2	1212	c.990G>A	c.(988-990)TCG>TCA	p.S330S	GPR12_uc010tdl.1_Silent_p.S171S	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	330	Cytoplasmic (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		CATCACTGGGCGAGCGCGCTC	0.542000													17	31					0	0	1	0	0	
USP12	219333	broad.mit.edu	37	13	27645266	27645266	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:27645266T>C	uc001uqy.2	-	8	1206	c.953A>G	c.(952-954)TAT>TGT	p.Y318C		NM_182488	NP_872294	O75317	UBP12_HUMAN	ubiquitin thiolesterase 12	318					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(1)	1		Lung SC(185;0.0161)		all cancers(112;0.0508)|GBM - Glioblastoma multiforme(144;0.168)|Epithelial(112;0.244)|OV - Ovarian serous cystadenocarcinoma(117;0.246)		TATTGCAATATAATGGCCTCG	0.274000													22	31					0	0	1	0	0	
SLC46A3	283537	broad.mit.edu	37	13	29292078	29292078	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:29292078T>C	uc001usi.2	-	1	1028	c.58A>G	c.(58-60)ACC>GCC	p.T20A	SLC46A3_uc001usg.2_5'Flank|SLC46A3_uc001usj.2_Missense_Mutation_p.T20A|SLC46A3_uc001ush.2_Missense_Mutation_p.T20A|SLC46A3_uc001usk.2_5'Flank	NM_181785	NP_861450	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3 isoform a	20					transmembrane transport	integral to membrane				central_nervous_system(1)|skin(1)	2		Lung SC(185;0.0367)		all cancers(112;0.159)		AGTGGACCGGTCAAAGTCATA	0.368000													30	46					0	0	1	0	0	
SPG20	23111	broad.mit.edu	37	13	36888472	36888472	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:36888472G>A	uc001uvn.2	-	7	1645	c.1375C>T	c.(1375-1377)CGG>TGG	p.R459W	SPG20_uc010ten.1_Missense_Mutation_p.R449W|SPG20_uc001uvm.2_Missense_Mutation_p.R459W|SPG20_uc001uvo.2_Missense_Mutation_p.R459W|SPG20_uc001uvq.2_Missense_Mutation_p.R459W	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	459					cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		GGTTGAATCCGCTCTCGGAGT	0.458000													35	77					0	0	1	0	0	
SMAD9	4093	broad.mit.edu	37	13	37427804	37427804	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:37427804A>C	uc001uvw.2	-	6	1355	c.1012T>G	c.(1012-1014)TTG>GTG	p.L338V	SMAD9_uc001uvx.2_Missense_Mutation_p.L301V|SMAD9_uc010tep.1_Missense_Mutation_p.L131V	NM_001127217	NP_001120689	O15198	SMAD9_HUMAN	SMAD family member 9 isoform a	338	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity				0		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		ACGTAGTACAAGTGCACACCT	0.542000													12	34					0	0	1	0	0	
POSTN	10631	broad.mit.edu	37	13	38171373	38171373	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:38171373A>T	uc001uwo.3	-	2	284	c.166T>A	c.(166-168)TAC>AAC	p.Y56N	POSTN_uc001uwp.3_Missense_Mutation_p.Y56N|POSTN_uc001uwr.2_Missense_Mutation_p.Y56N|POSTN_uc001uwq.2_Missense_Mutation_p.Y56N|POSTN_uc010teu.1_Missense_Mutation_p.Y56N|POSTN_uc010tev.1_Missense_Mutation_p.Y56N|POSTN_uc010tew.1_Missense_Mutation_p.Y56N|POSTN_uc010tex.1_5'UTR	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	56	EMI.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GTGCTGAAGTATTTCTTTTTG	0.353000													19	33					0	0	1	0	0	
C13orf23	80209	broad.mit.edu	37	13	39586971	39586971	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:39586971G>A	uc001uwy.2	-	11	3291	c.2418C>T	c.(2416-2418)TTC>TTT	p.F806F	C13orf23_uc001uwz.2_Silent_p.F784F	NM_025138	NP_079414	Q86XN7	CM023_HUMAN	hypothetical protein LOC80209 isoform 1	806										ovary(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)	5		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;3.7e-08)|Epithelial(112;4.28e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00114)|BRCA - Breast invasive adenocarcinoma(63;0.00366)|GBM - Glioblastoma multiforme(144;0.0146)		GCAGCCCCGGGAATGAGGGAA	0.567000													9	106					0	0	1	0	0	
MTRF1	9617	broad.mit.edu	37	13	41834765	41834765	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:41834765C>T	uc001uxx.2	-	4	749	c.279G>A	c.(277-279)CTG>CTA	p.L93L	MTRF1_uc001uxy.2_Silent_p.L93L|MTRF1_uc001uxz.2_5'UTR|MTRF1_uc010tff.1_Silent_p.L106L|MTRF1_uc001uyc.1_Silent_p.L93L	NM_004294	NP_004285	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	93					regulation of translational termination	mitochondrion	translation release factor activity, codon specific				0		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		GGATATGCTGCAGACATTGCT	0.448000													77	150					0	0	1	0	0	
TNFSF11	8600	broad.mit.edu	37	13	43174915	43174915	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:43174915C>T	uc001uyu.2	+	3	564	c.415C>T	c.(415-417)CAC>TAC	p.H139Y	TNFSF11_uc001uyt.2_Missense_Mutation_p.H66Y	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	139	Extracellular (Potential).	Cleavage (By similarity).			immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		TGGATCACAGCACATCAGAGC	0.333000													20	36					0	0	1	0	0	
NUFIP1	26747	broad.mit.edu	37	13	45563529	45563529	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:45563529G>A	uc001uzp.2	-	1	85	c.43C>T	c.(43-45)CAT>TAT	p.H15Y	KIAA1704_uc010tfo.1_5'Flank|KIAA1704_uc001uzq.2_5'Flank|KIAA1704_uc001uzr.1_5'Flank|KIAA1704_uc001uzs.2_5'Flank	NM_012345	NP_036477	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein	15					box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding				0		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		GGAGACGCATGCCACCCGATA	0.637000													4	11					0	0	1	0	0	
SIAH3	283514	broad.mit.edu	37	13	46358084	46358084	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:46358084G>A	uc001vap.2	-	2	326	c.244C>T	c.(244-246)CGC>TGC	p.R82C		NM_198849	NP_942146	Q8IW03	SIAH3_HUMAN	seven in absentia homolog 3	82	SIAH-type; degenerate.|His-rich.				multicellular organismal development|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding			ovary(1)|skin(1)	2						gcgtggtggcggaggtggtgg	0.428000													20	20					0	0	1	0	0	
C13orf18	80183	broad.mit.edu	37	13	46917563	46917563	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:46917563G>A	uc010acl.2	-	15	2551	c.1946C>T	c.(1945-1947)GCG>GTG	p.A649V	C13orf18_uc010tfy.1_Missense_Mutation_p.A172V|C13orf18_uc001vbf.3_Missense_Mutation_p.A582V|C13orf18_uc001vbg.3_Missense_Mutation_p.A377V|C13orf18_uc010tfz.1_Missense_Mutation_p.A492V|C13orf18_uc010acm.2_Missense_Mutation_p.A514V|C13orf18_uc010acn.2_Missense_Mutation_p.A434V|C13orf18_uc001vbe.3_Nonsense_Mutation_p.R598*|C13orf18_uc001vbh.3_Missense_Mutation_p.A649V|C13orf18_uc001vbi.3_Missense_Mutation_p.A492V	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	649											0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		TTTTCTCCTCGCTGTGATCCT	0.517000													16	32					0	0	1	0	0	
RCBTB2	1102	broad.mit.edu	37	13	49085916	49085916	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:49085916C>T	uc001vch.2	-	9	1144	c.773G>A	c.(772-774)CGT>CAT	p.R258H	RCBTB2_uc010tgg.1_Missense_Mutation_p.R263H|RCBTB2_uc001vci.2_Missense_Mutation_p.R234H|RCBTB2_uc010tgh.1_Missense_Mutation_p.V32M|RCBTB2_uc001vcj.2_Missense_Mutation_p.R262H|RCBTB2_uc010acv.1_RNA|RCBTB2_uc010tgi.1_Missense_Mutation_p.R234H	NM_001268	NP_001259	O95199	RCBT2_HUMAN	regulator of chromosome condensation and BTB	258	RCC1 4.						Ran guanyl-nucleotide exchange factor activity			ovary(2)|lung(2)|skin(1)	5		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		CCTCTGGACACGGATGCCTTG	0.493000													17	30					0	0	1	0	0	
FNDC3A	22862	broad.mit.edu	37	13	49781277	49781277	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:49781277C>T	uc001vcm.2	+	26	3648	c.3343C>T	c.(3343-3345)CGC>TGC	p.R1115C	FNDC3A_uc001vcn.2_Missense_Mutation_p.R1115C|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcq.2_Missense_Mutation_p.R1059C	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	1115	Fibronectin type-III 9.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		CTGTGAATATCGCTTCCGTGT	0.488000													32	61					0	0	1	0	0	
KPNA3	3839	broad.mit.edu	37	13	50296165	50296165	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:50296165G>A	uc001vdj.2	-	9	1067	c.652C>T	c.(652-654)CGG>TGG	p.R218W		NM_002267	NP_002258	O00505	IMA3_HUMAN	karyopherin alpha 3	218	NLS binding site (major) (By similarity).|ARM 4.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|protein complex assembly	cytoplasm|nuclear pore	nuclear localization sequence binding|protein transporter activity				0		Lung NSC(96;2.46e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.42e-09)		GTGACGTTCCGAAGGAAGGTG	0.478000													27	50					0	0	1	0	0	
CCDC70	83446	broad.mit.edu	37	13	52439720	52439720	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:52439720T>C	uc001vfu.3	+	2	502	c.206T>C	c.(205-207)ATG>ACG	p.M69T	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	69						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		AGGGAAGAGATGTGGACTTTC	0.463000													28	52					0	0	1	0	0	
ATP7B	540	broad.mit.edu	37	13	52513215	52513215	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:52513215C>T	uc001vfw.2	-	17	3828	c.3671G>A	c.(3670-3672)CGG>CAG	p.R1224Q	ATP7B_uc010adv.2_Missense_Mutation_p.R794Q|ATP7B_uc001vfx.2_Missense_Mutation_p.R1017Q|ATP7B_uc001vfy.2_Missense_Mutation_p.R1113Q|ATP7B_uc010tgt.1_Missense_Mutation_p.R1159Q|ATP7B_uc010tgu.1_Missense_Mutation_p.R1176Q|ATP7B_uc010tgv.1_Missense_Mutation_p.R1146Q|ATP7B_uc001vfv.2_Missense_Mutation_p.R496Q|ATP7B_uc010tgs.1_Missense_Mutation_p.R435Q	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1224	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GGCTGTCTTCCGGTTGTCCCC	0.527000									Wilson_disease				30	52					0	0	1	0	0	
THSD1P1	374500	broad.mit.edu	37	13	52742420	52742420	+	RNA	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:52742420C>T	uc001vgk.2	-	9		c.2178G>A			THSD1P1_uc001vgm.1_RNA|THSD1P1_uc010adx.1_RNA|THSD1P1_uc010ady.1_RNA|THSD1P1_uc001vgl.1_RNA					Homo sapiens cDNA FLJ14630 fis, clone NT2RP2000459.												0						TCCTGCCTGGCGATCCCCAAG	0.473000													27	30					0	0	1	0	0	
PCDH8	5100	broad.mit.edu	37	13	53421516	53421516	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:53421516G>A	uc001vhi.2	-	1	1259	c.1056C>T	c.(1054-1056)CCC>CCT	p.P352P	PCDH8_uc001vhj.2_Silent_p.P352P	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	352	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		TGGCGATGTCGGGTGCGTTGT	0.736000													13	5					0	0	1	0	0	
PCDH17	27253	broad.mit.edu	37	13	58207236	58207236	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:58207236C>T	uc001vhq.1	+	1	1448	c.556C>T	c.(556-558)CGC>TGC	p.R186C	PCDH17_uc010aec.1_Missense_Mutation_p.R186C	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	186	Extracellular (Potential).|Cadherin 2.|Cell attachment site (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CGTTAAGTCCCGCGGCGACGG	0.637000													9	13					0	0	1	0	0	
PCDH17	27253	broad.mit.edu	37	13	58298910	58298910	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:58298910G>A	uc001vhq.1	+	4	3854	c.2962G>A	c.(2962-2964)GAA>AAA	p.E988K	PCDH17_uc010aec.1_Missense_Mutation_p.E987K|PCDH17_uc001vhr.1_Missense_Mutation_p.E77K	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	988	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGAGACTTACGAAACTGTGAA	0.413000													27	29					0	0	1	0	0	
SLITRK1	114798	broad.mit.edu	37	13	84454612	84454612	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:84454612C>T	uc001vlk.2	-	1	1917	c.1031G>A	c.(1030-1032)GGC>GAC	p.G344D		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	344	Extracellular (Potential).|LRRNT 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCAGCTGCAGCCCCCAGGGCA	0.542000													28	56					0	0	1	0	0	
SLITRK5	26050	broad.mit.edu	37	13	88330138	88330138	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:88330138C>T	uc001vln.2	+	2	2714	c.2495C>T	c.(2494-2496)GCC>GTC	p.A832V	SLITRK5_uc010tic.1_Missense_Mutation_p.A591V	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	832	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CGGAGCCCCGCCTACAGCGTC	0.473000													9	18					0	0	1	0	0	
GPC5	2262	broad.mit.edu	37	13	92345484	92345484	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:92345484T>C	uc010tif.1	+	3	735	c.369T>C	c.(367-369)AGT>AGC	p.S123S		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	123						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				ATTACACCAGTATACTTTTTT	0.433000													22	37					0	0	1	0	0	
IPO5	3843	broad.mit.edu	37	13	98637707	98637707	+	Silent	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:98637707T>A	uc001vnf.1	+	3	269	c.204T>A	c.(202-204)CGT>CGA	p.R68R	IPO5_uc001vne.2_Silent_p.R86R|IPO5_uc010tik.1_Silent_p.R68R|IPO5_uc010til.1_Silent_p.R8R	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	68	Importin N-terminal.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						TCCTAAGACGTCTCTTGTCCT	0.403000													37	62					0	0	1	0	0	
DOCK9	23348	broad.mit.edu	37	13	99520227	99520227	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:99520227C>T	uc001vnt.2	-	29	3187	c.3132G>A	c.(3130-3132)AAG>AAA	p.K1044K	DOCK9_uc001vnw.2_Silent_p.K1043K|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.K1044K|DOCK9_uc010tis.1_Silent_p.K1043K|DOCK9_uc010tit.1_Silent_p.K1044K|DOCK9_uc010tiq.1_Silent_p.K8K|DOCK9_uc010afu.1_Silent_p.K890K	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1044					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGTTGATCTGCTTGAAGACAA	0.433000													17	12					0	0	1	0	0	
FAM155A	728215	broad.mit.edu	37	13	108518676	108518676	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:108518676T>C	uc001vql.2	-	1	785	c.269A>G	c.(268-270)CAG>CGG	p.Q90R		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	90	Poly-Gln.					integral to membrane	binding			skin(1)	1						ctgctgctgctgccgctgcct	0.408000													15	14					0	0	1	0	0	
LIG4	3981	broad.mit.edu	37	13	108861668	108861668	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:108861668G>T	uc001vqn.2	-	2	2222	c.1949C>A	c.(1948-1950)ACT>AAT	p.T650N	LIG4_uc001vqo.2_Missense_Mutation_p.T650N|LIG4_uc010agg.1_Missense_Mutation_p.T583N|LIG4_uc010agf.2_Missense_Mutation_p.T650N|LIG4_uc001vqp.2_Missense_Mutation_p.T650N	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	650					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					GTTAACGTTAGTAAGGTTAGG	0.373000								NHEJ					19	40					3.99206e-14	4.22023e-14	1	1	0	
COL4A1	1282	broad.mit.edu	37	13	110828808	110828808	+	Silent	SNP	C	T	T	rs148308759		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:110828808C>T	uc001vqw.3	-	36	3143	c.3021G>A	c.(3019-3021)CCG>CCA	p.P1007P	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1007	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTTTTGGTCCCGGAAGTCCTG	0.473000													8	67					0	0	1	0	0	
CARS2	79587	broad.mit.edu	37	13	111358282	111358282	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:111358282C>A	uc001vrd.2	-	1	199	c.159G>T	c.(157-159)CAG>CAT	p.Q53H	CARS2_uc010tjm.1_Intron	NM_024537	NP_078813	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial	53					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding				0	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	TGTTGTACACCTGCACACCCG	0.607000													3	3					1	1	1	1	0	
C13orf16	121793	broad.mit.edu	37	13	111980580	111980580	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:111980580C>T	uc001vsa.2	+	3	238	c.109C>T	c.(109-111)CGA>TGA	p.R37*		NM_152324	NP_689537	Q8N6K0	CM016_HUMAN	hypothetical protein LOC121793	37	Extracellular (Potential).					integral to membrane					0	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		all cancers(43;0.113)|GBM - Glioblastoma multiforme(44;0.174)|BRCA - Breast invasive adenocarcinoma(86;0.188)			CTCCAGGGACCGATGCCAGGA	0.567000													26	36					0	0	1	0	0	
C13orf28	122258	broad.mit.edu	37	13	113052428	113052428	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:113052428G>T	uc001vsd.1	+	3	248	c.217G>T	c.(217-219)GCA>TCA	p.A73S		NM_145248	NP_660291	Q96KW9	SPAC7_HUMAN	hypothetical protein LOC122258 precursor	73						extracellular region					0	all_lung(23;0.000633)|Lung NSC(43;0.0161)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0997)|Medulloblastoma(90;0.163)					GCCAAGTACAGCATCAACATT	0.438000													5	86					3.59834e-05	3.65893e-05	1	1	0	
OR4K1	79544	broad.mit.edu	37	14	20404217	20404217	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:20404217A>G	uc001vwj.1	+	1	392	c.392A>G	c.(391-393)CAC>CGC	p.H131R		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AAGCCTCTGCACTACAGTACA	0.438000													35	112					0	0	1	0	0	
CHD8	57680	broad.mit.edu	37	14	21896280	21896280	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:21896280C>T	uc001was.1	-	4	606	c.512G>A	c.(511-513)CGC>CAC	p.R171H	CHD8_uc001war.1_Missense_Mutation_p.R67H	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	450					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTCCAATCTGCGGTTTTCCTC	0.522000													47	113					0	0	1	0	0	
TOX4	9878	broad.mit.edu	37	14	21961062	21961062	+	Silent	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:21961062T>A	uc001waz.2	+	7	1390	c.1287T>A	c.(1285-1287)GCT>GCA	p.A429A	TOX4_uc001way.2_Silent_p.A299A|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Silent_p.A406A|TOX4_uc010tlv.1_Silent_p.A299A	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	429	Gln/Pro-rich.|Poly-Ala.					chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		CAGCAGCAGCTGCTGCTGCTG	0.582000													82	111					0	0	1	0	0	
OR10G3	26533	broad.mit.edu	37	14	22038482	22038482	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:22038482G>A	uc010tmb.1	-	1	394	c.394C>T	c.(394-396)CGC>TGC	p.R132C		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	132	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		ACAGGGTAGCGCAGGGGCTGA	0.552000													15	31					0	0	1	0	0	
FOXG1	2290	broad.mit.edu	37	14	29237391	29237391	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:29237391C>T	uc001wqe.2	+	1	1105	c.906C>T	c.(904-906)CGC>CGT	p.R302R		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	302				RAGSLYWPMSPFLSLHHPR -> APAPSTGPCRPSCPCTTP (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCATGGACCGCGCCGGCTCCC	0.701000													40	50					0	0	1	0	0	
PRKD1	5587	broad.mit.edu	37	14	30107951	30107951	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:30107951A>G	uc001wqh.2	-	5	1037	c.856T>C	c.(856-858)TAC>CAC	p.Y286H		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	286	Phorbol-ester/DAG-type 2.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TTCTTGCAGTACTGGCACACT	0.473000													15	27					0	0	1	0	0	
NPAS3	64067	broad.mit.edu	37	14	34269285	34269285	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:34269285C>T	uc001wru.2	+	12	1836	c.1772C>T	c.(1771-1773)GCG>GTG	p.A591V	NPAS3_uc001wrs.2_Missense_Mutation_p.A578V|NPAS3_uc001wrt.2_Missense_Mutation_p.A559V|NPAS3_uc001wrv.2_Missense_Mutation_p.A561V	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	591					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GAGGCGGGCGCGCAGGCCTCC	0.697000													5	8					0	0	1	0	0	
BAZ1A	11177	broad.mit.edu	37	14	35234330	35234330	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:35234330G>A	uc001wsk.2	-	22	4014	c.3446C>T	c.(3445-3447)GCG>GTG	p.A1149V	BAZ1A_uc001wsl.2_Missense_Mutation_p.A1117V	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1149	PHD-type.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CTTGCAACGCGCATTCAGTAT	0.443000													15	36					0	0	1	0	0	
SSTR1	6751	broad.mit.edu	37	14	38679518	38679518	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:38679518G>A	uc001wul.1	+	3	1541	c.924G>A	c.(922-924)TCG>TCA	p.S308S	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	308	Helical; Name=7; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GTCAGCTGTCGGTCATCCTCG	0.552000													55	59					0	0	1	0	0	
CTAGE5	4253	broad.mit.edu	37	14	39748655	39748655	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:39748655C>T	uc001wvg.3	+	4	556	c.220C>T	c.(220-222)CGA>TGA	p.R74*	CTAGE5_uc010tqe.1_Nonsense_Mutation_p.R62*|CTAGE5_uc001wuz.3_Nonsense_Mutation_p.R62*|CTAGE5_uc001wuy.3_Translation_Start_Site|CTAGE5_uc001wvb.3_Nonsense_Mutation_p.R45*|CTAGE5_uc001wvc.3_Nonsense_Mutation_p.R45*|CTAGE5_uc001wva.3_Nonsense_Mutation_p.R45*|CTAGE5_uc001wve.1_Nonsense_Mutation_p.R45*|CTAGE5_uc001wvh.3_Nonsense_Mutation_p.R74*|CTAGE5_uc001wvf.3_Translation_Start_Site|CTAGE5_uc001wvi.3_Nonsense_Mutation_p.R74*|CTAGE5_uc010amz.2_Translation_Start_Site|CTAGE5_uc001wvj.3_Nonsense_Mutation_p.R45*	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	74							enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TTTTTTAGGACGAGAGAAAAA	0.294000													14	36					0	0	1	0	0	
CTAGE5	4253	broad.mit.edu	37	14	39790150	39790150	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:39790150C>A	uc001wvg.3	+	19	1898	c.1562C>A	c.(1561-1563)CCC>CAC	p.P521H	CTAGE5_uc010tqe.1_Missense_Mutation_p.P483H|CTAGE5_uc001wuz.3_Missense_Mutation_p.P509H|CTAGE5_uc001wuy.3_Missense_Mutation_p.P441H|CTAGE5_uc001wvb.3_Intron|CTAGE5_uc001wvc.3_Intron|CTAGE5_uc001wva.3_Missense_Mutation_p.P492H|CTAGE5_uc001wvh.3_Intron|CTAGE5_uc001wvf.3_Missense_Mutation_p.P446H|CTAGE5_uc001wvi.3_Missense_Mutation_p.P526H|CTAGE5_uc010amz.2_Missense_Mutation_p.P137H|CTAGE5_uc001wvj.3_Missense_Mutation_p.P492H	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	521	Pro-rich.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		CCATATGGTCCCTCACCATTG	0.428000													39	75					5.73435e-26	6.18635e-26	1	1	0	
FBXO33	254170	broad.mit.edu	37	14	39871611	39871611	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:39871611A>T	uc001wvk.2	-	2	1042	c.704T>A	c.(703-705)ATT>AAT	p.I235N		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	F-box protein 33	235											0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		TTACTGTTTAATTTTTTTGCC	0.318000													18	41					0	0	1	0	0	
KLHL28	54813	broad.mit.edu	37	14	45414389	45414389	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:45414389C>T	uc001wvq.2	-	2	989	c.743G>A	c.(742-744)CGC>CAC	p.R248H	KLHL28_uc001wvr.2_Missense_Mutation_p.R248H|KLHL28_uc001wvt.3_Missense_Mutation_p.R248H	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	248										ovary(1)	1						TTTACAAGTGCGATCATCACG	0.383000													24	47					0	0	1	0	0	
FAM179B	23116	broad.mit.edu	37	14	45431631	45431631	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:45431631G>A	uc001wvv.2	+	1	216	c.7G>A	c.(7-9)GCT>ACT	p.A3T	FAM179B_uc001wvw.2_Missense_Mutation_p.A3T|FAM179B_uc010anc.2_RNA|KLHL28_uc001wvq.2_5'Flank|KLHL28_uc001wvr.2_5'Flank|FAM179B_uc010anb.1_Missense_Mutation_p.A3T|FAM179B_uc001wvu.2_Missense_Mutation_p.A3T	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	3							binding			skin(2)|upper_aerodigestive_tract(1)	3						CTGCATGGCGGCTGCCCCCTC	0.617000													21	28					0	0	1	0	0	
FAM179B	23116	broad.mit.edu	37	14	45497410	45497410	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:45497410A>G	uc001wvv.2	+	10	3745	c.3536A>G	c.(3535-3537)AAC>AGC	p.N1179S	FAM179B_uc001wvw.2_Missense_Mutation_p.N1179S|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1179							binding			skin(2)|upper_aerodigestive_tract(1)	3						TCTACTTATAACAAGATGAGA	0.303000													6	51					0	0	1	0	0	
FANCM	57697	broad.mit.edu	37	14	45605395	45605395	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:45605395A>G	uc001wwd.3	+	1	260	c.161A>G	c.(160-162)GAT>GGT	p.D54G	FANCM_uc001wwc.2_Missense_Mutation_p.D54G|FANCM_uc010anf.2_Missense_Mutation_p.D54G|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	54					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						GAGTCGGACGATGATGTGTTG	0.642000								Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				34	39					0	0	1	0	0	
C14orf106	55320	broad.mit.edu	37	14	45693275	45693275	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:45693275C>T	uc001wwf.2	-	11	2974	c.2515G>A	c.(2515-2517)GTC>ATC	p.V839I		NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	839					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						GTTTCTTTGACGGAAGGTCTA	0.368000													14	38					0	0	1	0	0	
C14orf106	55320	broad.mit.edu	37	14	45711515	45711515	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:45711515T>C	uc001wwf.2	-	4	1324	c.865A>G	c.(865-867)AGT>GGT	p.S289G	C14orf106_uc010anh.2_RNA	NM_018353	NP_060823	Q6P0N0	M18BP_HUMAN	chromosome 14 open reading frame 106	289					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding				0						CAATTAGTACTGAGAGTCTCA	0.368000													6	96					0	0	1	0	0	
SOS2	6655	broad.mit.edu	37	14	50611935	50611935	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:50611935T>C	uc001wxs.3	-	16	2718	c.2620A>G	c.(2620-2622)AGT>GGT	p.S874G	SOS2_uc010tql.1_Missense_Mutation_p.S841G|SOS2_uc010tqm.1_RNA	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	874	Ras-GEF.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					TTTACTGCACTGACTATCTCC	0.338000													4	78					0	0	1	0	0	
FRMD6	122786	broad.mit.edu	37	14	52178272	52178272	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:52178272G>A	uc001wzd.2	+	8	1023	c.738G>A	c.(736-738)TCG>TCA	p.S246S	FRMD6_uc001wzb.2_Silent_p.S238S|FRMD6_uc001wzc.2_Silent_p.S238S|FRMD6_uc001wze.2_Silent_p.S169S|FRMD6_uc001wzf.2_5'Flank	NM_152330	NP_689543	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	246	FERM.					cytoskeleton|mitochondrion|plasma membrane	binding			ovary(1)|breast(1)|central_nervous_system(1)	3	all_epithelial(31;0.0163)|Breast(41;0.089)					TTGAAGCATCGCTGACTCTTG	0.338000													26	47					0	0	1	0	0	
PELI2	57161	broad.mit.edu	37	14	56645119	56645119	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:56645119G>A	uc001xch.2	+	2	430	c.144G>A	c.(142-144)CGG>CGA	p.R48R		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	48					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						TCTACAAGCGGCCCAAGGCAA	0.517000													41	55					0	0	1	0	0	
DAAM1	23002	broad.mit.edu	37	14	59789729	59789729	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:59789729C>T	uc001xdz.1	+	6	685	c.560C>T	c.(559-561)GCG>GTG	p.A187V	DAAM1_uc001xea.1_Missense_Mutation_p.A187V|DAAM1_uc001xeb.1_Missense_Mutation_p.A187V	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	187	GBD/FH3.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		TGTATAAAGGCGTTAATGAAC	0.438000													21	34					0	0	1	0	0	
GPR135	64582	broad.mit.edu	37	14	59930994	59930994	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:59930994G>A	uc010apj.2	-	1	1066	c.951C>T	c.(949-951)TAC>TAT	p.Y317Y	GPR135_uc001xed.2_RNA	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	G protein-coupled receptor 135	317	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0				OV - Ovarian serous cystadenocarcinoma(108;0.134)		GCACGCGCGCGTAGGTGTTCA	0.642000													15	21					0	0	1	0	0	
DCAF5	8816	broad.mit.edu	37	14	69521952	69521952	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:69521952C>A	uc001xkp.2	-	9	1670	c.1451G>T	c.(1450-1452)GGG>GTG	p.G484V	DCAF5_uc001xkq.2_Missense_Mutation_p.G483V	NM_003861	NP_003852	Q96JK2	DCAF5_HUMAN	WD repeat domain 22	484						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)	2						CCGCAGGGGCCCCAGGTGGAA	0.627000													24	24					5.45024e-15	5.77664e-15	1	1	0	
MAP3K9	4293	broad.mit.edu	37	14	71199761	71199761	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:71199761G>A	uc001xmm.2	-	11	2325	c.2325C>T	c.(2323-2325)TGC>TGT	p.C775C	MAP3K9_uc010ttk.1_Silent_p.C503C|MAP3K9_uc001xmk.2_Silent_p.C508C|MAP3K9_uc001xml.2_Silent_p.C789C	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	775					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GAAGCAGCTGGCACTTGCCAG	0.652000													24	40					0	0	1	0	0	
PCNX	22990	broad.mit.edu	37	14	71444403	71444403	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:71444403G>T	uc001xmo.2	+	6	1795	c.1349G>T	c.(1348-1350)AGC>ATC	p.S450I	PCNX_uc001xmn.3_Missense_Mutation_p.S450I|PCNX_uc010are.1_Missense_Mutation_p.S450I	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	450						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		AAAAGGACTAGCAGTGAAAAG	0.522000													5	42					1.23904e-05	1.26366e-05	1	1	0	
C14orf169	79697	broad.mit.edu	37	14	73958888	73958888	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:73958888C>T	uc001xok.1	+	3	1246	c.1167C>T	c.(1165-1167)ACC>ACT	p.T389T	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	389	JmjC.				negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		TGCTGCAGACCGTGCTGGAAC	0.577000													62	98					0	0	1	0	0	
HEATR4	399671	broad.mit.edu	37	14	73989186	73989186	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:73989186C>T	uc010tub.1	-	3	993	c.671G>A	c.(670-672)CGA>CAA	p.R224Q	HEATR4_uc010tua.1_Missense_Mutation_p.R177Q	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		CCCAGGCCTTCGAGGACGCTT	0.612000													18	32					0	0	1	0	0	
LTBP2	4053	broad.mit.edu	37	14	74975410	74975410	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:74975410C>A	uc001xqa.2	-	24	3936	c.3549G>T	c.(3547-3549)GAG>GAT	p.E1183D		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1183	Cys-rich.|EGF-like 12; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CGCAGTGCTCCTCCCCCATGC	0.652000													19	25					3.10358e-05	3.15741e-05	1	1	0	
LTBP2	4053	broad.mit.edu	37	14	74995223	74995223	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:74995223C>T	uc001xqa.2	-	12	2718	c.2331G>A	c.(2329-2331)ACG>ACA	p.T777T		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	777					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GCCAGGTGTCCGTGACGACCC	0.647000													25	36					0	0	1	0	0	
C14orf4	64207	broad.mit.edu	37	14	77492225	77492225	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:77492225C>T	uc001xsy.2	-	1	2810	c.1911G>A	c.(1909-1911)GCG>GCA	p.A637A		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	637						nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		TGGGCGAGTGCGCTGTGCCCA	0.682000													11	18					0	0	1	0	0	
ALKBH1	8846	broad.mit.edu	37	14	78174328	78174328	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:78174328G>A	uc001xuc.1	-	1	29	c.20C>T	c.(19-21)GCC>GTC	p.A7V	ALKBH1_uc001xud.1_RNA|C14orf156_uc001xue.3_5'Flank	NM_006020	NP_006011	Q13686	ALKB1_HUMAN	alkylated DNA repair protein alkB homolog	7					DNA dealkylation involved in DNA repair|DNA demethylation|oxidative demethylation|RNA repair	mitochondrion	DNA-(apurinic or apyrimidinic site) lyase activity|ferrous iron binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)|skin(1)	2			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		AGAGCCCACGGCCGCTGCCAT	0.637000													28	34					0	0	1	0	0	
NRXN3	9369	broad.mit.edu	37	14	80328229	80328229	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:80328229G>A	uc001xun.2	+	17	3599	c.3108G>A	c.(3106-3108)ACG>ACA	p.T1036T	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Silent_p.T612T|NRXN3_uc010asw.2_Silent_p.T434T|NRXN3_uc001xur.3_Silent_p.T407T	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1618	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCAACGGCACGCTCATGAAGG	0.532000													15	22					0	0	1	0	0	
TSHR	7253	broad.mit.edu	37	14	81610526	81610526	+	Silent	SNP	G	A	A	rs145012289	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:81610526G>A	uc001xvd.1	+	10	2280	c.2124G>A	c.(2122-2124)GGG>GGA	p.G708G		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	708	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	CATACCGGGGGCAGAGGGTTC	0.493000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						47	71					0	0	1	0	0	
FOXN3	1112	broad.mit.edu	37	14	89878419	89878419	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:89878419G>A	uc001xxo.3	-	2	539	c.402C>T	c.(400-402)CGC>CGT	p.R134R	FOXN3_uc001xxn.3_Silent_p.R134R|FOXN3_uc010atk.2_Silent_p.R134R|FOXN3_uc001xxp.2_Silent_p.R134R	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1	134	Fork-head.				DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						TCACTGGCAGGCGCTTGGTTG	0.483000													38	70					0	0	1	0	0	
TTC7B	145567	broad.mit.edu	37	14	91142998	91142998	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:91142998G>A	uc001xyp.2	-	9	1143	c.1021C>T	c.(1021-1023)CGG>TGG	p.R341W	TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	341							binding			ovary(2)	2		Melanoma(154;0.222)				ACAGCGTCCCGGTTGGCCTGA	0.537000													27	49					0	0	1	0	0	
CCDC88C	440193	broad.mit.edu	37	14	91779774	91779774	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:91779774G>A	uc010aty.2	-	15	2485	c.2386C>T	c.(2386-2388)CGC>TGC	p.R796C		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	796	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				AGCGCCTGGCGCTCAGCCTCC	0.687000													5	18					0	0	1	0	0	
FBLN5	10516	broad.mit.edu	37	14	92347755	92347755	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:92347755G>A	uc001xzx.3	-	9	1343	c.870C>T	c.(868-870)AAC>AAT	p.N290N	FBLN5_uc010aud.2_Silent_p.N295N|FBLN5_uc010aue.2_Silent_p.N331N	NM_006329	NP_006320	Q9UBX5	FBLN5_HUMAN	fibulin 5 precursor	290	EGF-like 6; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6		all_cancers(154;0.0722)				GCTCACATTCGTTGATGTCTG	0.547000													26	52					0	0	1	0	0	
FAM181A	90050	broad.mit.edu	37	14	94394791	94394791	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:94394791C>T	uc001ybz.1	+	3	653	c.346C>T	c.(346-348)CGG>TGG	p.R116W	C14orf86_uc001yby.2_5'Flank|FAM181A_uc010aus.1_Missense_Mutation_p.R54W|FAM181A_uc001yca.1_Missense_Mutation_p.R54W	NM_138344	NP_612353	Q8N9Y4	F181A_HUMAN	hypothetical protein LOC90050	116											0						GAAGTATTCCCGGCTCCCGCG	0.637000													18	20					0	0	1	0	0	
DEGS2	123099	broad.mit.edu	37	14	100615484	100615484	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:100615484A>C	uc001ygx.2	-	2	734	c.646T>G	c.(646-648)TCC>GCC	p.S216A		NM_206918	NP_996801	Q6QHC5	DEGS2_HUMAN	degenerative spermatocyte homolog 2, lipid	216	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity				0		Melanoma(154;0.212)				CCCAGGAAGGAGCTGGCCAGC	0.647000													30	47					0	0	1	0	0	
WDR25	79446	broad.mit.edu	37	14	100992378	100992378	+	Splice_Site	SNP	G	A	A	rs142505900		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:100992378G>A	uc010avx.2	+	5	1365	c.1272_splice	c.e5+1	p.H424_splice	WDR25_uc001yhm.2_Splice_Site_p.H416_splice|WDR25_uc001yhn.2_Splice_Site_p.H424_splice|WDR25_uc010avy.2_Splice_Site|WDR25_uc001yho.2_Splice_Site_p.H167_splice	NM_001161476	NP_001154948	Q64LD2	WDR25_HUMAN	WD repeat domain 25												0		Melanoma(154;0.212)				GATTTTCCACGTAAGAAATCC	0.542000													23	18					0	0	1	0	0	
MIR431	574038	broad.mit.edu	37	14	101347457	101347457	+	RNA	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:101347457G>A	hsa-mir-431|MI0001721	+			c.114G>A			RTL1_uc010txj.1_Silent_p.H1223H|MIR433_hsa-mir-433|MI0001723_5'Flank|uc001yig.3_5'Flank|MIR127_hsa-mir-127|MI0000472_5'Flank																	0						CACCAACGACGTGCAGCTCCA	0.617000													5	5					0	0	1	0	0	
PPP2R5C	5527	broad.mit.edu	37	14	102372842	102372842	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:102372842G>A	uc001yko.2	+	10	1267	c.1127G>A	c.(1126-1128)CGC>CAC	p.R376H	PPP2R5C_uc010txr.1_Missense_Mutation_p.R407H|PPP2R5C_uc001ykk.2_Missense_Mutation_p.R431H|PPP2R5C_uc010txt.1_Missense_Mutation_p.R366H|PPP2R5C_uc001ykn.2_Missense_Mutation_p.R376H|PPP2R5C_uc001ykp.2_Missense_Mutation_p.R376H|PPP2R5C_uc001ykq.2_Intron	NM_002719	NP_002710	Q13362	2A5G_HUMAN	gamma isoform of regulatory subunit B56, protein	376					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein binding|protein phosphatase type 2A regulator activity|protein phosphatase type 2A regulator activity			ovary(1)|breast(1)	2						TCCTTGTACCGCAACTCAAAG	0.398000													40	72					0	0	1	0	0	
DYNC1H1	1778	broad.mit.edu	37	14	102476662	102476662	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:102476662C>T	uc001yks.2	+	31	6435	c.6271C>T	c.(6271-6273)CGG>TGG	p.R2091W		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2091	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CTTCGGTCTTCGGGCTTTGAA	0.428000													27	43					0	0	1	0	0	
TECPR2	9895	broad.mit.edu	37	14	102918829	102918829	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:102918829G>A	uc001ylw.1	+	16	3653	c.3505G>A	c.(3505-3507)GCC>ACC	p.A1169T	TECPR2_uc010awl.2_Missense_Mutation_p.A1169T|TECPR2_uc010txx.1_Missense_Mutation_p.A332T	NM_014844	NP_055659	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1169							protein binding			lung(1)|central_nervous_system(1)|skin(1)	3						GCCTCCCGAAGCCGAGATGCG	0.682000													7	17					0	0	1	0	0	
C14orf73	91828	broad.mit.edu	37	14	103566847	103566847	+	Silent	SNP	C	T	T	rs147118623		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:103566847C>T	uc001ymk.2	+	1	367	c.291C>T	c.(289-291)ACC>ACT	p.T97T		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	97											0		Melanoma(154;0.155)	Epithelial(46;0.221)			GCCCAGCTACCGGCCATTCCC	0.632000													13	15					0	0	1	0	0	
C14orf73	91828	broad.mit.edu	37	14	103574001	103574001	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:103574001C>T	uc001ymk.2	+	9	1811	c.1735C>T	c.(1735-1737)CGC>TGC	p.R579C		NM_001077594	NP_001071062	Q17RC7	EX3L4_HUMAN	hypothetical protein LOC91828	579											0		Melanoma(154;0.155)	Epithelial(46;0.221)			GTTCGTGGTCCGCGAGTACCT	0.602000													4	1					0	0	1	0	0	
EIF5	1983	broad.mit.edu	37	14	103803484	103803484	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:103803484A>T	uc001ymq.2	+	6	881	c.359A>T	c.(358-360)AAT>ATT	p.N120I	EIF5_uc001ymr.2_Missense_Mutation_p.N120I|EIF5_uc001yms.2_Missense_Mutation_p.N120I|EIF5_uc001ymt.2_Missense_Mutation_p.N120I|EIF5_uc001ymu.2_Missense_Mutation_p.N120I|SNORA28_uc001ymv.1_5'Flank	NM_001969	NP_001960	P55010	IF5_HUMAN	eukaryotic translation initiation factor 5	120					regulation of translational initiation|RNA metabolic process	cytosol	GTP binding|GTPase activity|translation initiation factor activity			pancreas(1)|breast(1)|skin(1)	3		Melanoma(154;0.155)	Epithelial(46;0.182)			ACAATAGGTAATTCTTGTAAA	0.368000													8	91					0	0	1	0	0	
MARK3	4140	broad.mit.edu	37	14	103934416	103934416	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:103934416A>G	uc001ymz.3	+	12	1823	c.1157A>G	c.(1156-1158)AAG>AGG	p.K386R	MARK3_uc001ymx.3_Missense_Mutation_p.K386R|MARK3_uc001ymw.3_Missense_Mutation_p.K386R|MARK3_uc001yna.3_Splice_Site_p.V371_splice|MARK3_uc001ymy.3_Missense_Mutation_p.K307R|MARK3_uc010awp.2_Missense_Mutation_p.K409R|MARK3_uc010tyb.1_Splice_Site_p.V182_splice	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	386							ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			TCACTTGCTAAGGTTAGGCCG	0.443000													30	49					0	0	1	0	0	
C14orf180	400258	broad.mit.edu	37	14	105054178	105054178	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:105054178C>T	uc001yow.1	+	3	505	c.204C>T	c.(202-204)CGC>CGT	p.R68R	C14orf180_uc010tyh.1_Silent_p.R68R|C14orf180_uc010awy.1_Silent_p.R68R	NM_001008404	NP_001008404	Q8N912	CN180_HUMAN	hypothetical protein LOC400258	68						integral to membrane					0		Melanoma(154;0.226)	all cancers(16;0.00405)|OV - Ovarian serous cystadenocarcinoma(23;0.0319)|Epithelial(46;0.0784)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.127)		CCTCGAGGCGCGTGTGGTTCC	0.677000													6	11					0	0	1	0	0	
KIAA0284	283638	broad.mit.edu	37	14	105352923	105352923	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:105352923C>T	uc010axb.2	+	12	2571	c.2347C>T	c.(2347-2349)CGG>TGG	p.R783W	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.R713W|KIAA0284_uc001yps.2_Missense_Mutation_p.R689W|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	783						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GAGCAGGGGTCGGCGCTCACC	0.692000													4	16					0	0	1	0	0	
CDCA4	55038	broad.mit.edu	37	14	105478046	105478046	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:105478046G>A	uc001yqa.2	-	2	317	c.221C>T	c.(220-222)ACG>ATG	p.T74M	CDCA4_uc001yqb.2_Missense_Mutation_p.T74M	NM_145701	NP_663747	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	74	SERTA.					nucleus				ovary(1)	1		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		CCCATCCTGCGTCATCTCCTC	0.642000													27	38					0	0	1	0	0	
GPR132	29933	broad.mit.edu	37	14	105518286	105518286	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:105518286G>A	uc001yqd.2	-	4	1087	c.188C>T	c.(187-189)ACT>ATT	p.T63I	GPR132_uc001yqc.2_5'UTR|GPR132_uc001yqe.2_Missense_Mutation_p.T54I	NM_013345	NP_037477	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	63	Helical; Name=1; (Potential).				response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		CAGCCACGCAGTCAGGCAGTT	0.642000													26	43					0	0	1	0	0	
JAG2	3714	broad.mit.edu	37	14	105612833	105612833	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:105612833G>A	uc001yqg.2	-	22	3002	c.2598C>T	c.(2596-2598)ATC>ATT	p.I866I	JAG2_uc010axf.2_5'UTR|JAG2_uc001yqf.2_Silent_p.I270I|JAG2_uc001yqh.2_Silent_p.I828I	NM_002226	NP_002217	Q9Y219	JAG2_HUMAN	jagged 2 isoform a precursor	866	Extracellular (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			lung(3)|breast(2)	5		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCCCGAACCCGATCACTGTGG	0.682000													25	30					0	0	1	0	0	
BTBD6	90135	broad.mit.edu	37	14	105716436	105716436	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:105716436C>T	uc010tyq.1	+	5	993	c.885C>T	c.(883-885)AAC>AAT	p.N295N	BRF1_uc010tyo.1_Intron|BRF1_uc010typ.1_Intron|BRF1_uc001yql.2_5'Flank|BRF1_uc001yqo.2_5'Flank|BRF1_uc010axg.1_Intron|BRF1_uc001yqp.2_Intron|BRF1_uc001yqn.2_5'Flank|BRF1_uc010axh.1_5'Flank|BRF1_uc010axj.1_5'Flank	NM_033271	NP_150374	Q96KE9	BTBD6_HUMAN	BTB domain protein BDPL	295						cytoplasmic mRNA processing body					0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.0163)|Epithelial(46;0.0391)	Epithelial(152;0.18)		AGTTTGCCAACGGCGCTGCCC	0.597000													30	68					0	0	1	0	0	
ADAM6	8755	broad.mit.edu	37	14	106091693	106091693	+	RNA	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:106091693G>A	uc010tyt.1	-	3646		c.61933C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron					Parts of antibodies, mostly variable regions.												0						GGGCATGATGGGCATGGGGGA	0.602000													56	233					0	0	1	0	0	
ADAM6	8755	broad.mit.edu	37	14	106110436	106110436	+	RNA	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:106110436G>A	uc010tyt.1	-	3641		c.60933C>T			uc001yrs.2_Intron|uc001yrt.2_Intron|uc001yrw.1_Intron|uc001yrx.1_Intron|uc001yrz.1_RNA					Parts of antibodies, mostly variable regions.												0						CACAACATTTGCGCTCTGCAG	0.607000													19	147					0	0	1	0	0	
ADAM6	8755	broad.mit.edu	37	14	107199215	107199215	+	RNA	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:107199215T>G	uc010tyt.1	-	21		c.1483A>C								Parts of antibodies, mostly variable regions.												0						TCCCCCAGACTCCACCAGCTG	0.572000													46	67					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	15	20644812	20644812	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:20644812A>G	uc001ytg.2	-	21	3155	c.2446T>C	c.(2446-2448)TTC>CTC	p.F816L	uc010tyx.1_RNA|uc001yth.3_Missense_Mutation_p.F816L|uc010tyy.1_Missense_Mutation_p.F816L					RecName: Full=Putative HERC2-like protein 3;																		CTCCCCAAGAAGTCAAACAGC	0.547000													6	26					0	0	1	0	0	
OR4M2	390538	broad.mit.edu	37	15	22369050	22369050	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:22369050C>T	uc010tzu.1	+	1	475	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTCTATCATACAGGTGGCTCT	0.507000													56	284					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	15	22440617	22440617	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:22440617G>A	uc001yug.2	-	1	249	c.230C>T	c.(229-231)ACG>ATG	p.T77M						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).																		ATCGATGATCGTTGTTTTATG	0.483000													11	50					0	0	1	0	0	
NIPA1	123606	broad.mit.edu	37	15	23049010	23049010	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:23049010G>A	uc001yvc.2	-	5	834	c.809C>T	c.(808-810)ACG>ATG	p.T270M	NIPA1_uc001yvd.2_Missense_Mutation_p.T100M|NIPA1_uc001yve.2_Missense_Mutation_p.T195M	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	270	Helical; (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		CAGGACCAGCGTGGTAAACAC	0.602000													15	22					0	0	1	0	0	
ATP10A	57194	broad.mit.edu	37	15	25925385	25925385	+	Missense_Mutation	SNP	G	A	A	rs146387652		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:25925385G>A	uc010ayu.2	-	20	3855	c.3749C>T	c.(3748-3750)GCG>GTG	p.A1250V		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1250	Extracellular (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGCACAAGACGCATTGTAAAT	0.493000													34	72					0	0	1	0	0	
ATP10A	57194	broad.mit.edu	37	15	25958891	25958891	+	Silent	SNP	G	A	A	rs139578740		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:25958891G>A	uc010ayu.2	-	10	2380	c.2274C>T	c.(2272-2274)ACC>ACT	p.T758T		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	758	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGATCTCATCGGTAAGCGGGT	0.617000													19	39					0	0	1	0	0	
GABRA5	2558	broad.mit.edu	37	15	27188486	27188486	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:27188486G>A	uc001zbd.1	+	11	1341	c.1002G>A	c.(1000-1002)GCG>GCA	p.A334A	GABRA5_uc001zbe.1_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	334	Helical; (Potential).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCTTCTCGGCGCTGATAGAGT	0.542000													3	5					0	0	1	0	0	
HERC2	8924	broad.mit.edu	37	15	28437159	28437159	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:28437159C>T	uc001zbj.2	-	53	8505	c.8399G>A	c.(8398-8400)CGT>CAT	p.R2800H	HERC2_uc001zbk.1_Missense_Mutation_p.R335H	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	2800	DOC.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTCAATGAGACGGGATGCCTG	0.597000											OREG0022997	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	104					0	0	1	0	0	
RYR3	6263	broad.mit.edu	37	15	33858966	33858966	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:33858966C>T	uc001zhi.2	+	12	1304	c.1234C>T	c.(1234-1236)CGG>TGG	p.R412W	RYR3_uc010bar.2_Missense_Mutation_p.R412W	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	412	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCGGATCATCCGGAACACTAC	0.537000													24	55					0	0	1	0	0	
GOLGA8A	23015	broad.mit.edu	37	15	34673720	34673720	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:34673720G>A	uc001zii.2	-	16	1813	c.1704C>T	c.(1702-1704)GTC>GTT	p.V568V	GOLGA8A_uc001zih.2_Silent_p.V424V|uc001zil.2_5'Flank	NM_181077	NP_851422	A7E2F4	GOG8A_HUMAN	golgi autoantigen, golgin subfamily a, 8A	596	Golgi-targeting domain (By similarity).			V -> I (in Ref. 1; AAF28463, 2; BAA74878, 4; AAI44610/AAI50330/AAI52411 and 5; CAH18214).		Golgi cisterna membrane					0		all_lung(180;2.78e-08)		all cancers(64;8.27e-19)|GBM - Glioblastoma multiforme(113;6.98e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		GGAGCTGCACGACTGGCTGTG	0.592000													22	127					0	0	1	0	0	
MEIS2	4212	broad.mit.edu	37	15	37375970	37375970	+	Splice_Site	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:37375970A>G	uc001zjr.2	-	7	1791	c.754_splice	c.e7+1	p.G252_splice	MEIS2_uc001zjl.2_Splice_Site_p.G239_splice|MEIS2_uc010ucj.1_Splice_Site_p.G239_splice|MEIS2_uc001zjm.2_Splice_Site_p.G164_splice|MEIS2_uc001zjn.2_Splice_Site_p.G106_splice|MEIS2_uc001zjo.2_Splice_Site_p.G252_splice|MEIS2_uc001zjp.2_Splice_Site_p.G252_splice|MEIS2_uc001zjs.2_Splice_Site_p.G252_splice|MEIS2_uc001zju.2_Splice_Site_p.G239_splice|MEIS2_uc001zjt.2_Splice_Site_p.G252_splice	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c						negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TTGACCTTTTACCTTGCTCAC	0.502000													22	43					0	0	1	0	0	
PLCB2	5330	broad.mit.edu	37	15	40590816	40590816	+	Missense_Mutation	SNP	G	A	A	rs143144314	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:40590816G>A	uc001zld.2	-	10	1245	c.944C>T	c.(943-945)ACG>ATG	p.T315M	PLCB2_uc010bbo.2_Missense_Mutation_p.T315M|PLCB2_uc010ucm.1_Missense_Mutation_p.T315M	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	315	PI-PLC X-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GAGTGGCTGCGTCATGTCGTG	0.572000													26	31					0	0	1	0	0	
DISP2	85455	broad.mit.edu	37	15	40659533	40659533	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:40659533C>T	uc001zlk.1	+	8	1309	c.1220C>T	c.(1219-1221)GCC>GTC	p.A407V		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	407					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CAGAGTAGTGCCATCTACCAA	0.577000													78	175					0	0	1	0	0	
DISP2	85455	broad.mit.edu	37	15	40661144	40661144	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:40661144G>A	uc001zlk.1	+	8	2920	c.2831G>A	c.(2830-2832)CGT>CAT	p.R944H		NM_033510	NP_277045	A7MBM2	DISP2_HUMAN	dispatched B	944					smoothened signaling pathway	integral to membrane				ovary(2)	2		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		GGCCTCCGCCGTGGTTGGTTC	0.622000													44	70					0	0	1	0	0	
C15orf23	90417	broad.mit.edu	37	15	40685709	40685709	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:40685709C>T	uc001zll.2	+	9	977	c.862C>T	c.(862-864)CGA>TGA	p.R288*	C15orf23_uc010ucp.1_3'UTR|C15orf23_uc001zlo.2_3'UTR|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	288	Potential.					nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		GGAAAGAGTCCGATTCCTAGA	0.358000													35	62					0	0	1	0	0	
RPAP1	26015	broad.mit.edu	37	15	41812993	41812993	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:41812993G>A	uc001zod.2	-	22	3515	c.3391C>T	c.(3391-3393)CGG>TGG	p.R1131W	RPAP1_uc001zoc.2_Missense_Mutation_p.R150W	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1131	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		TGCAGGACCCGCATGGCTGTG	0.662000													27	32					0	0	1	0	0	
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42139703	42139703	+	Missense_Mutation	SNP	C	T	T	rs141583854	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:42139703C>T	uc010bco.2	+	19	2217	c.2116C>T	c.(2116-2118)CGG>TGG	p.R706W	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.R937W|JMJD7-PLA2G4B_uc010bcn.2_Intron|JMJD7-PLA2G4B_uc001zoq.3_Missense_Mutation_p.R407W	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	706	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						CGACTCCTTCCGGGAGTACTC	0.662000													40	63					0	0	1	0	0	
TMEM87A	25963	broad.mit.edu	37	15	42519917	42519917	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:42519917A>G	uc010udd.1	-	14	1450	c.1291T>C	c.(1291-1293)TGT>CGT	p.C431R		NM_015497	NP_056312	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A isoform 1	431						integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		ACCGACTGACATGTCACTATT	0.363000													18	39					0	0	1	0	0	
ZFP106	64397	broad.mit.edu	37	15	42734448	42734448	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:42734448C>T	uc001zpw.2	-	7	3852	c.3517G>A	c.(3517-3519)GGA>AGA	p.G1173R	ZFP106_uc001zpu.2_Missense_Mutation_p.G358R|ZFP106_uc001zpv.2_Missense_Mutation_p.G358R|ZFP106_uc001zpx.2_Missense_Mutation_p.G401R	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	1173						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		AGAGAGGCTCCGGTGGGTGAT	0.507000													38	49					0	0	1	0	0	
ZFP106	64397	broad.mit.edu	37	15	42743379	42743379	+	Missense_Mutation	SNP	G	A	A	rs142329440		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:42743379G>A	uc001zpw.2	-	2	1357	c.1022C>T	c.(1021-1023)GCG>GTG	p.A341V	ZFP106_uc001zpu.2_5'Flank|ZFP106_uc001zpv.2_Intron|ZFP106_uc001zpx.2_Intron|ZFP106_uc010udh.1_Missense_Mutation_p.A124V|ZFP106_uc001zpy.1_Missense_Mutation_p.A364V	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	zinc finger protein 106 homolog	341						nucleolus	zinc ion binding			central_nervous_system(2)|ovary(1)	3		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		TTCCCTTGCCGCACTGCCATT	0.468000													6	96					0	0	1	0	0	
UBR1	197131	broad.mit.edu	37	15	43237587	43237587	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:43237587C>T	uc001zqq.2	-	47	5256	c.5190G>A	c.(5188-5190)GAG>GAA	p.E1730E		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1730					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		TCCTAGCAATCTCTTCTATAA	0.443000													18	40					0	0	1	0	0	
CCNDBP1	23582	broad.mit.edu	37	15	43482524	43482524	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:43482524C>A	uc001zqv.2	+	6	661	c.430C>A	c.(430-432)CCT>ACT	p.P144T	CCNDBP1_uc001zqu.2_Missense_Mutation_p.P16T|CCNDBP1_uc010bdc.2_Missense_Mutation_p.P144T|CCNDBP1_uc010bdb.2_Missense_Mutation_p.P16T|CCNDBP1_uc010udl.1_5'UTR|CCNDBP1_uc001zqw.2_RNA|CCNDBP1_uc001zqx.2_Missense_Mutation_p.P16T|CCNDBP1_uc010bdd.2_Missense_Mutation_p.P16T|CCNDBP1_uc001zqy.2_Missense_Mutation_p.P16T	NM_012142	NP_036274	O95273	CCDB1_HUMAN	cyclin D-type binding-protein 1 isoform 1	144	Required for interaction with CCND1.|Interaction with RPLP0.|Interaction with TCF3.				cell cycle	cytoplasm|nucleus	protein binding			ovary(1)|kidney(1)	2		all_cancers(109;3.31e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.42e-07)		TTTCCCCAGCCCTGAGAACAA	0.458000													19	28					1.96292e-10	2.04979e-10	1	1	0	
TUBGCP4	27229	broad.mit.edu	37	15	43675642	43675642	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:43675642C>T	uc001zro.2	+	7	903	c.663C>T	c.(661-663)GAC>GAT	p.D221D	TUBGCP4_uc001zrn.2_Silent_p.D221D|TUBGCP4_uc010bdh.2_RNA	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	221					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		CAGAAGAGGACGAGGAGGATC	0.527000													12	35					0	0	1	0	0	
TUBGCP4	27229	broad.mit.edu	37	15	43692300	43692300	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:43692300C>T	uc001zro.2	+	14	1720	c.1480C>T	c.(1480-1482)CAC>TAC	p.H494Y	TUBGCP4_uc001zrn.2_Missense_Mutation_p.H493Y|TUBGCP4_uc010bdh.2_RNA	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	494					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		TGAGCTGCAGCACTGCTGGGC	0.453000													15	27					0	0	1	0	0	
DUOX2	50506	broad.mit.edu	37	15	45399615	45399615	+	Missense_Mutation	SNP	G	A	A	rs140940946	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:45399615G>A	uc010bea.2	-	14	1824	c.1621C>T	c.(1621-1623)CGG>TGG	p.R541W	DUOX2_uc001zun.2_Missense_Mutation_p.R541W	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	541	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		AGCACGTCCCGCAGGGTGGTA	0.537000													43	63					0	0	1	0	0	
DUOX2	50506	broad.mit.edu	37	15	45404879	45404879	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:45404879G>T	uc010bea.2	-	4	401	c.198C>A	c.(196-198)GCC>GCA	p.A66A	DUOX2_uc001zun.2_Silent_p.A66A|DUOXA2_uc001zuo.2_5'Flank|DUOXA2_uc010beb.2_5'Flank	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	66	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ACACACCGTCGGCGTAATTGG	0.682000													32	60					1.47244e-24	1.58434e-24	1	1	0	
PLDN	26258	broad.mit.edu	37	15	45884368	45884368	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:45884368G>A	uc001zvq.2	+	2	343	c.118G>A	c.(118-120)GAG>AAG	p.E40K	PLDN_uc001zvr.2_RNA|PLDN_uc001zvs.2_RNA	NM_012388	NP_036520	Q9UL45	PLDN_HUMAN	pallidin	40					post-Golgi vesicle-mediated transport|synaptic vesicle docking involved in exocytosis	BLOC-1 complex|endomembrane system|membrane	identical protein binding|syntaxin-13 binding			skin(1)	1		Lung NSC(122;1.6e-06)|all_lung(180;1.13e-05)|Melanoma(134;0.027)		all cancers(107;6.58e-18)|GBM - Glioblastoma multiforme(94;5.91e-07)		AGGGTTAATAGAGGACTTGAC	0.358000													23	41					0	0	1	0	0	
CYP19A1	1588	broad.mit.edu	37	15	51503148	51503148	+	Nonsense_Mutation	SNP	G	A	A	rs72552260		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:51503148G>A	uc001zyz.3	-	11	1620	c.1369C>T	c.(1369-1371)CGA>TGA	p.R457*	CYP19A1_uc001zza.3_Nonsense_Mutation_p.R457*	NM_031226	NP_112503	P11511	CP19A_HUMAN	cytochrome P450, family 19	457					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(3)	3				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	ACGTGGAATCGTCTCAGAAGT	0.468000													31	53					0	0	1	0	0	
MYO5C	55930	broad.mit.edu	37	15	52556467	52556467	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:52556467C>T	uc010bff.2	-	9	1104	c.967G>A	c.(967-969)GTT>ATT	p.V323I	MYO5C_uc010uga.1_RNA|MYO5C_uc010ugb.1_RNA|MYO5C_uc010ugc.1_Silent_p.T222T	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	323	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		ATTTTAAAAACGTCCATCTGA	0.438000													13	30					0	0	1	0	0	
UNC13C	440279	broad.mit.edu	37	15	54786877	54786877	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:54786877A>C	uc002ack.2	+	18	5005	c.5005A>C	c.(5005-5007)AAT>CAT	p.N1669H		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1669	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATGGTTTTATAATGAATATGT	0.323000													38	68					0	0	1	0	0	
UNC13C	440279	broad.mit.edu	37	15	54916051	54916051	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:54916051A>G	uc002ack.2	+	30	6258	c.6258A>G	c.(6256-6258)GAA>GAG	p.E2086E	UNC13C_uc002acm.2_Silent_p.E7E	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2086	C2 2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		CCTTTGTGGAAGTTTGTATAC	0.388000													17	30					0	0	1	0	0	
NEDD4	4734	broad.mit.edu	37	15	56144650	56144650	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:56144650G>A	uc002adj.2	-	9	2675	c.2375C>T	c.(2374-2376)ACG>ATG	p.T792M	NEDD4_uc002adl.2_Missense_Mutation_p.T373M|NEDD4_uc002adi.2_Missense_Mutation_p.T720M|NEDD4_uc010ugj.1_Missense_Mutation_p.T776M|NEDD4_uc010bfm.2_Missense_Mutation_p.T775M|NEDD4_uc002adk.2_RNA	NM_198400	NP_006145	P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally	792	Mediates interaction with TNIK (By similarity).|WW 2.				development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|breast(1)	4				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		CCAAGTAGTCGTTCTGGAATT	0.378000													20	37					0	0	1	0	0	
SLTM	79811	broad.mit.edu	37	15	59181694	59181694	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:59181694T>C	uc002afp.2	-	16	2227	c.2139A>G	c.(2137-2139)CAA>CAG	p.Q713Q	SLTM_uc002afn.2_Silent_p.Q255Q|SLTM_uc002afo.2_Silent_p.Q695Q|SLTM_uc002afq.2_Silent_p.Q282Q|SLTM_uc010bgd.2_Silent_p.Q282Q	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	713	Arg/Glu-rich.|Potential.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						GAAGCTGCTGTTGTTGCCTTC	0.413000													28	36					0	0	1	0	0	
TLN2	83660	broad.mit.edu	37	15	63000909	63000909	+	Missense_Mutation	SNP	G	A	A	rs145362831		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:63000909G>A	uc002alb.3	+	18	2381	c.2381G>A	c.(2380-2382)CGA>CAA	p.R794Q		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	794					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						TTTGCCAGCCGAGGCGAGCCC	0.617000													23	25					0	0	1	0	0	
USP3	9960	broad.mit.edu	37	15	63824852	63824852	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:63824852G>A	uc002amf.2	+	2	227	c.98G>A	c.(97-99)CGG>CAG	p.R33Q	USP3_uc010uii.1_RNA|USP3_uc002amg.2_5'UTR|USP3_uc002amh.2_Missense_Mutation_p.R11Q|USP3_uc010uij.1_Missense_Mutation_p.R33Q|USP3_uc010uik.1_Intron|USP3_uc010bgs.2_Missense_Mutation_p.R16Q	NM_006537	NP_006528	Q9Y6I4	UBP3_HUMAN	ubiquitin thiolesterase 3	33	UBP-type.				DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(80;0.0187)		TTAGTGTGCCGGTCCAACAAA	0.363000													37	48					0	0	1	0	0	
SMAD3	4088	broad.mit.edu	37	15	67473668	67473668	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:67473668G>A	uc002aqj.2	+	6	1046	c.748G>A	c.(748-750)GCC>ACC	p.A250T	SMAD3_uc010ujr.1_Missense_Mutation_p.A145T|SMAD3_uc010ujs.1_Missense_Mutation_p.A206T|SMAD3_uc010ujt.1_Missense_Mutation_p.A55T	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	250	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GACATTCCACGCCTCGCAGCC	0.592000													23	31					0	0	1	0	0	
LBXCOR1	390598	broad.mit.edu	37	15	68122574	68122574	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:68122574C>T	uc002aqy.1	+	5	2321	c.2321C>T	c.(2320-2322)ACG>ATG	p.T774M		NM_001031807	NP_001026977	P84550	SKOR1_HUMAN	transcriptional corepressor Corl1	818					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity				0						GATTTGGAAACGAGGAAATCC	0.517000													20	30					0	0	1	0	0	
PKM2	5315	broad.mit.edu	37	15	72511345	72511345	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:72511345G>A	uc002atx.1	-	2	335	c.94C>T	c.(94-96)CGC>TGC	p.R32C	PKM2_uc010bit.1_Missense_Mutation_p.R37C|PKM2_uc010uki.1_Missense_Mutation_p.R106C|PKM2_uc002atv.1_Missense_Mutation_p.R67C|PKM2_uc002atw.1_Missense_Mutation_p.R32C|PKM2_uc002aty.1_Missense_Mutation_p.R32C|PKM2_uc010ukj.1_Silent_p.A47A|PKM2_uc010ukk.1_Missense_Mutation_p.R32C|PKM2_uc010biu.1_Missense_Mutation_p.R53C|PKM2_uc002atz.1_RNA	NM_182471	NP_872271	P14618	KPYM_HUMAN	pyruvate kinase, muscle isoform M1	32					glycolysis|programmed cell death	cytosol|nucleus|plasma membrane	ATP binding|magnesium ion binding|potassium ion binding|protein binding|pyruvate kinase activity			breast(1)	1					Pyruvic acid(DB00119)	ATGTCCAGGCGGCACATGTGC	0.572000													28	41					0	0	1	0	0	
NEO1	4756	broad.mit.edu	37	15	73581529	73581529	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:73581529G>T	uc002avm.3	+	25	3834	c.3692G>T	c.(3691-3693)CGA>CTA	p.R1231L	NEO1_uc010ukx.1_Missense_Mutation_p.R1220L|NEO1_uc010uky.1_Missense_Mutation_p.R1231L|NEO1_uc010ukz.1_Missense_Mutation_p.R644L|NEO1_uc002avn.3_Missense_Mutation_p.R869L	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	1231	Cytoplasmic (Potential).				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						GCTGGAAGGCGAGGAATGAGA	0.502000													16	19					1.5739e-10	1.64606e-10	1	1	0	
CD276	80381	broad.mit.edu	37	15	73996677	73996677	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:73996677G>A	uc002avv.1	+	6	1467	c.1233G>A	c.(1231-1233)TCG>TCA	p.S411S	CD276_uc010bjd.1_Silent_p.S265S|CD276_uc002avu.1_Silent_p.S411S|CD276_uc002avw.1_Silent_p.S193S|CD276_uc010ulb.1_Silent_p.S357S|CD276_uc002avx.2_RNA	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	411	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						TGACCACGTCGCAGATGGCCA	0.647000											OREG0023265	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	28					0	0	1	0	0	
LOXL1	4016	broad.mit.edu	37	15	74235272	74235272	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:74235272C>T	uc002awc.1	+	2	1516	c.1180C>T	c.(1180-1182)CGC>TGC	p.R394C		NM_005576	NP_005567	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1 preproprotein	394	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding				0						GTACTCCCTGCGCTGTGCTGC	0.587000													10	148					0	0	1	0	0	
GOLGA6A	342096	broad.mit.edu	37	15	74367334	74367334	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:74367334G>T	uc002axa.1	-	11	897	c.856C>A	c.(856-858)CCA>ACA	p.P286T		NM_001038640	NP_001033729	Q9NYA3	GOG6A_HUMAN	golgi autoantigen, golgin subfamily a, 6	286	Potential.										0						GCCAGGGATGGGGGCTCAGCT	0.537000													18	88					1.06801e-11	1.12212e-11	1	1	0	
ISLR	3671	broad.mit.edu	37	15	74468067	74468067	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:74468067C>T	uc002axg.1	+	2	1150	c.868C>T	c.(868-870)CGT>TGT	p.R290C	ISLR_uc002axh.1_Missense_Mutation_p.R290C	NM_005545	NP_005536	O14498	ISLR_HUMAN	immunoglobulin superfamily containing	290	Ig-like.				cell adhesion	extracellular region				large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						CACTGATGGGCGTGCCCTGCC	0.642000													43	85					0	0	1	0	0	
CCDC33	80125	broad.mit.edu	37	15	74627335	74627335	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:74627335G>A	uc002axo.2	+	18	2439	c.2045G>A	c.(2044-2046)CGC>CAC	p.R682H	CCDC33_uc002axp.2_Missense_Mutation_p.R538H|CCDC33_uc002axq.2_Missense_Mutation_p.R309H|CCDC33_uc002axr.2_Missense_Mutation_p.R275H	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	885	Potential.						protein binding			ovary(3)|skin(2)	5						TCAGCTCGACGCTGGGGACGA	0.572000													28	63					0	0	1	0	0	
CLK3	1198	broad.mit.edu	37	15	74911553	74911553	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:74911553C>T	uc010uln.1	+	2	921	c.460C>T	c.(460-462)CGA>TGA	p.R154*	CLK3_uc002ayg.3_Nonsense_Mutation_p.R6*|CLK3_uc002ayh.3_5'UTR|CLK3_uc010ulm.1_Nonsense_Mutation_p.R154*|CLK3_uc002ayj.3_Nonsense_Mutation_p.R6*|CLK3_uc002ayk.3_5'UTR	NM_001130028	NP_001123500	P49761	CLK3_HUMAN	CDC-like kinase 3 isoform a	154						acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)	2						TCACTGTAAGCGATACCGCTC	0.607000													64	85					0	0	1	0	0	
CSK	1445	broad.mit.edu	37	15	75094779	75094779	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:75094779C>T	uc010bkb.1	+	14	1461	c.1278C>T	c.(1276-1278)GAC>GAT	p.D426D	CSK_uc002ays.2_Silent_p.D426D|CSK_uc010bkc.1_Silent_p.D235D	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	426	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						GGCACCTGGACGCCGCCATGC	0.637000													36	68					0	0	1	0	0	
SIN3A	25942	broad.mit.edu	37	15	75664484	75664484	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:75664484C>A	uc002bai.2	-	21	3917	c.3658G>T	c.(3658-3660)GAG>TAG	p.E1220*	SIN3A_uc002baj.2_Nonsense_Mutation_p.E1220*|SIN3A_uc010uml.1_Nonsense_Mutation_p.E1220*	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1220					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						GGCACATGCTCCTTGGTCCAT	0.502000													45	83					3.94638e-17	4.20442e-17	1	1	0	
SNX33	257364	broad.mit.edu	37	15	75949393	75949393	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:75949393G>A	uc002bau.2	+	2	1658	c.1562G>A	c.(1561-1563)CGC>CAC	p.R521H	SNX33_uc002bav.2_Missense_Mutation_p.R134H	NM_153271	NP_695003	Q8WV41	SNX33_HUMAN	sorting nexin 33	521	BAR.				cell communication		phosphatidylinositol binding|protein binding			ovary(1)	1						AGGCGCTGCCGCGTGGTGGGT	0.627000													36	39					0	0	1	0	0	
CRABP1	1381	broad.mit.edu	37	15	78633425	78633425	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:78633425G>A	uc002bdp.2	+	2	216	c.111G>A	c.(109-111)GCG>GCA	p.A37A		NM_004378	NP_004369	P29762	RABP1_HUMAN	cellular retinoic acid binding protein 1	37					multicellular organismal development|signal transduction	cytoplasm	retinal binding|retinol binding|transporter activity				0					Alitretinoin(DB00523)|Etretinate(DB00926)	TAGCGGCTGCGTCCAAGCCGC	0.632000													7	14					0	0	1	0	0	
CTSH	1512	broad.mit.edu	37	15	79227367	79227367	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:79227367C>T	uc002ben.2	-	6	419	c.322G>A	c.(322-324)GTG>ATG	p.V108M	CTSH_uc010unf.1_RNA|CTSH_uc010bll.1_Intron|CTSH_uc010ung.1_Missense_Mutation_p.V120M	NM_148979	NP_683880	P09668	CATH_HUMAN	cathepsin H isoform b precursor	120					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(2)|large_intestine(1)	3						CGCCAGTCCACGGAAGGTGGG	0.458000													4	70					0	0	1	0	0	
KIAA1024	23251	broad.mit.edu	37	15	79760622	79760622	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:79760622G>A	uc002bew.1	+	4	2722	c.2647G>A	c.(2647-2649)GAA>AAA	p.E883K	KIAA1024_uc010unk.1_3'UTR	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	883						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						TAAAGAAGCCGAATTCAGACG	0.433000													10	15					0	0	1	0	0	
KIAA1199	57214	broad.mit.edu	37	15	81173411	81173411	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:81173411G>A	uc002bfw.1	+	5	811	c.551G>A	c.(550-552)TGG>TAG	p.W184*	KIAA1199_uc010unn.1_Nonsense_Mutation_p.W184*	NM_018689	NP_061159	Q8WUJ3	K1199_HUMAN	KIAA1199 precursor	184										upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						GAAAGGAGCTGGGGCCACCGT	0.463000													6	144					0	0	1	0	0	
AEN	64782	broad.mit.edu	37	15	89169555	89169555	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:89169555C>T	uc002bmt.2	+	2	266	c.115C>T	c.(115-117)CGG>TGG	p.R39W	AEN_uc010bnl.2_Missense_Mutation_p.R39W|AEN_uc010bnm.1_Missense_Mutation_p.R39W	NM_022767	NP_073604	Q8WTP8	AEN_HUMAN	interferon stimulated exonuclease gene	39					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding				0						ACAGCACCAGCGGTTCATGGC	0.642000													6	11					0	0	1	0	0	
FANCI	55215	broad.mit.edu	37	15	89848426	89848426	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:89848426C>T	uc010bnp.1	+	29	3229	c.3139C>T	c.(3139-3141)CGT>TGT	p.R1047C	FANCI_uc002bnm.1_Missense_Mutation_p.R987C|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Missense_Mutation_p.R808C|FANCI_uc002bnq.1_Missense_Mutation_p.R460C	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	1047					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					CATTCTGCTGCGTGACTTGTC	0.483000								Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				39	63					0	0	1	0	0	
C15orf42	90381	broad.mit.edu	37	15	90169247	90169247	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:90169247C>T	uc002boe.2	+	21	5557	c.5557C>T	c.(5557-5559)CTG>TTG	p.L1853L	C15orf42_uc010upv.1_RNA	NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1853					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTCTCCGCTGCTGTTCCAGGG	0.562000													20	40					0	0	1	0	0	
ANPEP	290	broad.mit.edu	37	15	90349232	90349232	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:90349232G>A	uc002bop.3	-	2	875	c.583C>T	c.(583-585)CGC>TGC	p.R195C		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	195	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TACTCGCTGCGGTAGAAGCCC	0.622000													36	74					0	0	1	0	0	
CRTC3	64784	broad.mit.edu	37	15	91185350	91185350	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:91185350C>T	uc002bpp.2	+	15	1944	c.1838C>T	c.(1837-1839)ACG>ATG	p.T613M	CRTC3_uc002bpo.2_Missense_Mutation_p.T612M	NM_022769	NP_073606	Q6UUV7	CRTC3_HUMAN	transducer of regulated CREB protein 3 isoform	613					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus			CRTC3/MAML2(26)	salivary_gland(26)|ovary(1)	27	Melanoma(11;0.00551)|Lung NSC(78;0.0931)|all_lung(78;0.163)		BRCA - Breast invasive adenocarcinoma(143;0.0745)			GTTGAAGAGACGTTTCGAGCT	0.498000			T	MAML2	salivary gland mucoepidermoid								22	38					0	0	1	0	0	
BLM	641	broad.mit.edu	37	15	91312684	91312684	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:91312684G>A	uc002bpr.2	+	12	2520	c.2423G>A	c.(2422-2424)CGT>CAT	p.R808H	BLM_uc010uqh.1_Missense_Mutation_p.R808H|BLM_uc010uqi.1_Missense_Mutation_p.R433H|BLM_uc010bnx.2_Missense_Mutation_p.R808H|BLM_uc002bps.1_Missense_Mutation_p.R370H	NM_000057	NP_000048	P54132	BLM_HUMAN	Bloom syndrome protein	808	Helicase ATP-binding.				double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			ovary(3)|skin(2)|breast(1)	6	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			CATGATTTTCGTCAAGATTAC	0.413000			Mis|N|F			leukemia|lymphoma|skin squamous cell |other cancers		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Bloom_syndrome				48	48					0	0	1	0	0	
PRC1	9055	broad.mit.edu	37	15	91528045	91528045	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:91528045C>T	uc002bqm.2	-	2	179	c.22G>A	c.(22-24)GCG>ACG	p.A8T	PRC1_uc002bqn.2_Missense_Mutation_p.A8T|PRC1_uc002bqo.2_Missense_Mutation_p.A8T|PRC1_uc010uqs.1_Missense_Mutation_p.A8T|PRC1_uc010uqt.1_Intron	NM_003981	NP_003972	O43663	PRC1_HUMAN	protein regulator of cytokinesis 1 isoform 1	8	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			ovary(1)|skin(1)	2	Lung NSC(78;0.0987)|all_lung(78;0.175)					GACTCCTCCGCCAGCACCTCA	0.448000													36	61					0	0	1	0	0	
MCTP2	55784	broad.mit.edu	37	15	94901823	94901823	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:94901823A>G	uc002btj.2	+	9	1348	c.1283A>G	c.(1282-1284)CAT>CGT	p.H428R	MCTP2_uc010urg.1_3'UTR|MCTP2_uc002bti.2_Missense_Mutation_p.H428R|MCTP2_uc010boj.2_Missense_Mutation_p.H157R|MCTP2_uc010bok.2_Missense_Mutation_p.H428R|MCTP2_uc002btk.3_Missense_Mutation_p.H16R|MCTP2_uc002btl.2_Missense_Mutation_p.H16R	NM_018349	NP_060819	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2 isoform 1	428	C2 2.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			AACAAAAAGCATGAGGAACGT	0.507000													15	26					0	0	1	0	0	
IGF1R	3480	broad.mit.edu	37	15	99500322	99500322	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:99500322A>G	uc002bul.2	+	21	3805	c.3755A>G	c.(3754-3756)AAC>AGC	p.N1252S	IGF1R_uc010bon.2_Missense_Mutation_p.N1251S	NM_000875	NP_000866	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor precursor	1252	Protein kinase.|Cytoplasmic (Potential).				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			lung(3)|kidney(3)|ovary(1)|central_nervous_system(1)	8	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	TGGCAGTATAACCCCAAGATG	0.582000													34	53					0	0	1	0	0	
LRRK1	79705	broad.mit.edu	37	15	101586241	101586241	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:101586241C>T	uc002bwr.2	+	21	3338	c.3019C>T	c.(3019-3021)CGG>TGG	p.R1007W	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1007					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CCACGGTATGCGGCACCCCAC	0.562000													40	80					0	0	1	0	0	
LRRK1	79705	broad.mit.edu	37	15	101593491	101593491	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:101593491A>C	uc002bwr.2	+	26	4239	c.3920A>C	c.(3919-3921)GAG>GCG	p.E1307A	LRRK1_uc010usb.1_RNA|LRRK1_uc010usc.1_RNA|LRRK1_uc002bws.2_RNA	NM_024652	NP_078928	Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1307	Protein kinase.				small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|lung(4)|central_nervous_system(3)|large_intestine(1)	12	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCCGGCAGGAGGCCAGCATG	0.657000													20	31					0	0	1	0	0	
ITFG3	83986	broad.mit.edu	37	16	314628	314628	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:314628C>T	uc002cgf.2	+	12	1555	c.1360C>T	c.(1360-1362)CGG>TGG	p.R454W	ITFG3_uc002cgg.2_Missense_Mutation_p.R454W|ITFG3_uc010uud.1_RNA|ITFG3_uc002cgh.2_Missense_Mutation_p.R454W	NM_032039	NP_114428	Q9H0X4	ITFG3_HUMAN	integrin alpha FG-GAP repeat containing 3	454	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(16;0.000129)|all_epithelial(16;0.000206)|Hepatocellular(16;0.00264)|Lung NSC(18;0.0626)|all_lung(18;0.13)				CGGGGAGGCCCGGCACAGCCT	0.642000													19	29					0	0	1	0	0	
WFIKKN1	117166	broad.mit.edu	37	16	683935	683935	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:683935G>A	uc002cht.1	+	2	1767	c.1525G>A	c.(1525-1527)GAT>AAT	p.D509N	WFIKKN1_uc002chs.1_3'UTR|uc010uuk.1_5'Flank	NM_053284	NP_444514	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz	509	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity				0		Hepatocellular(780;0.00335)				TGAGGTGCGCGATGGCGTGGC	0.677000													3	7					0	0	1	0	0	
RHOT2	89941	broad.mit.edu	37	16	720697	720697	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:720697C>T	uc002cip.2	+	9	630	c.563C>T	c.(562-564)GCG>GTG	p.A188V	RHOT2_uc002ciq.2_Missense_Mutation_p.A81V|RHOT2_uc010bqy.2_5'Flank	NM_138769	NP_620124	Q8IXI1	MIRO2_HUMAN	ras homolog gene family, member T2	188	EF-hand 1.|Mitochondrial intermembrane (Potential).				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			pancreas(1)	1		Hepatocellular(780;0.0218)				TGCGCCCAGGCGCTGACGCGC	0.682000													41	74					0	0	1	0	0	
CHTF18	63922	broad.mit.edu	37	16	847749	847749	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:847749C>T	uc002cke.3	+	21	2852	c.2789C>T	c.(2788-2790)GCA>GTA	p.A930V	CHTF18_uc002ckf.3_Missense_Mutation_p.A958V|CHTF18_uc010brf.2_Missense_Mutation_p.A512V|CHTF18_uc002ckg.3_Missense_Mutation_p.A448V	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	930					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				GTCCCGAGTGCAGGTGTGTGT	0.632000													20	26					0	0	1	0	0	
CACNA1H	8912	broad.mit.edu	37	16	1270618	1270618	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:1270618G>A	uc002cks.2	+	35	6934	c.6686G>A	c.(6685-6687)AGG>AAG	p.R2229K	CACNA1H_uc002ckt.2_Missense_Mutation_p.R2223K|CACNA1H_uc002cku.2_Missense_Mutation_p.R924K|CACNA1H_uc010brj.2_Missense_Mutation_p.R940K|CACNA1H_uc002ckv.2_Missense_Mutation_p.R918K	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	2229	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ACGCCTCACAGGGACTCCCTG	0.756000													8	12					0	0	1	0	0	
BAIAP3	8938	broad.mit.edu	37	16	1395258	1395258	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:1395258G>A	uc002clk.1	+	22	2054	c.2054G>A	c.(2053-2055)CGC>CAC	p.R685H	BAIAP3_uc002clj.2_Missense_Mutation_p.R667H|BAIAP3_uc010uuz.1_Missense_Mutation_p.R650H|BAIAP3_uc010uva.1_Missense_Mutation_p.R622H|BAIAP3_uc010uvc.1_Missense_Mutation_p.R614H	NM_003933	NP_003924	O94812	BAIP3_HUMAN	BAI1-associated protein 3	685	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			pancreas(1)	1		Hepatocellular(780;0.0893)				AGGGACAGCCGCTCTCTGGCC	0.647000													42	46					0	0	1	0	0	
GNPTG	84572	broad.mit.edu	37	16	1412311	1412311	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:1412311C>T	uc002clm.2	+	7	551	c.516C>T	c.(514-516)CAC>CAT	p.H172H		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	172						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				GCCACCCCCACGCCTTGCTAG	0.687000													20	18					0	0	1	0	0	
IGFALS	3483	broad.mit.edu	37	16	1841250	1841250	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:1841250C>T	uc002cmy.2	-	2	1250	c.1169G>A	c.(1168-1170)AGC>AAC	p.S390N	IGFALS_uc010uvn.1_Missense_Mutation_p.S428N|IGFALS_uc010uvo.1_Missense_Mutation_p.S24N	NM_004970	NP_004961	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid	390	LRR 14.				cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding				0						CAGGTGCAGGCTGTGCAGCTT	0.667000													19	34					0	0	1	0	0	
RPL3L	6123	broad.mit.edu	37	16	1996656	1996656	+	Silent	SNP	G	A	A	rs141671269		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:1996656G>A	uc002cnh.2	-	7	968	c.921C>T	c.(919-921)TAC>TAT	p.Y307Y		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	307					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						CAGTCACGTCGTAGCTGGTGG	0.642000													25	37					0	0	1	0	0	
TSC2	7249	broad.mit.edu	37	16	2105425	2105425	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:2105425G>A	uc002con.2	+	6	610	c.504G>A	c.(502-504)ATG>ATA	p.M168I	TSC2_uc010bsd.2_Missense_Mutation_p.M168I|TSC2_uc002coo.2_Missense_Mutation_p.M168I|TSC2_uc010uvv.1_Missense_Mutation_p.M131I|TSC2_uc010uvw.1_Missense_Mutation_p.M119I|TSC2_uc002cop.2_Intron	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	168	Required for interaction with TSC1.				cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				TGCAGTGGATGGATGTTGGCT	0.552000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				48	72					0	0	1	0	0	
PKD1	5310	broad.mit.edu	37	16	2165400	2165400	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:2165400C>T	uc002cos.1	-	10	2285	c.2076G>A	c.(2074-2076)GCG>GCA	p.A692A	PKD1_uc002cot.1_Silent_p.A692A	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	692	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CGGGGGGCCCCGCGGGAACGG	0.682000													2	2					0	0	1	0	0	
CASKIN1	57524	broad.mit.edu	37	16	2228903	2228903	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:2228903C>T	uc010bsg.1	-	19	4231	c.4199G>A	c.(4198-4200)CGC>CAC	p.R1400H		NM_020764	NP_065815	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	1400					signal transduction	cytoplasm				skin(2)	2						ccgcaccTACCGCGGGCCCTG	0.373000													4	3					0	0	1	0	0	
ABCA3	21	broad.mit.edu	37	16	2328359	2328359	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:2328359G>A	uc002cpy.1	-	30	5360	c.4648C>T	c.(4648-4650)CGG>TGG	p.R1550W	ABCA3_uc010bsk.1_Missense_Mutation_p.R1492W	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	1550	ABC transporter 2.				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				AGCAGGCGCCGGGCCACGGGG	0.632000													33	49					0	0	1	0	0	
ABCA3	21	broad.mit.edu	37	16	2349441	2349441	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:2349441G>A	uc002cpy.1	-	14	2416	c.1704C>T	c.(1702-1704)AAC>AAT	p.N568N	ABCA3_uc010bsk.1_Silent_p.N510N|ABCA3_uc010bsl.1_Silent_p.N568N	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	568	ABC transporter 1.|ATP 1 (Potential).		N -> D (in SMDP3).		response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				TCCCGGCACCGTTGTGGCCCA	0.637000													7	107					0	0	1	0	0	
PRSS21	10942	broad.mit.edu	37	16	2871046	2871046	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:2871046G>A	uc002crt.2	+	5	747	c.641G>A	c.(640-642)CGC>CAC	p.R214H	PRSS21_uc002crs.2_Missense_Mutation_p.R212H|PRSS21_uc002crr.2_Missense_Mutation_p.R214H	NM_006799	NP_006790	Q9Y6M0	TEST_HUMAN	testisin isoform 1	214	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			ovary(1)|skin(1)	2						TACAGTTTCCGCAAGGACATC	0.552000													106	176					0	0	1	0	0	
NLRC3	197358	broad.mit.edu	37	16	3613868	3613868	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:3613868G>A	uc010btn.2	-	5	1481	c.1070C>T	c.(1069-1071)CCG>CTG	p.P357L		NM_178844	NP_849172	Q7RTR2	NLRC3_HUMAN	NOD3 protein	357	NACHT.				I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						CAGGGTCCTCGGGGGCCACAG	0.672000													19	34					0	0	1	0	0	
CREBBP	1387	broad.mit.edu	37	16	3828769	3828769	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:3828769G>A	uc002cvv.2	-	9	2077	c.1873C>T	c.(1873-1875)CGC>TGC	p.R625C	CREBBP_uc002cvw.2_Missense_Mutation_p.R587C	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	625	KIX.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TTTTCCATGCGGCGATCCTTT	0.463000			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				62	75					0	0	1	0	0	
VASN	114990	broad.mit.edu	37	16	4432309	4432309	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:4432309C>T	uc002cwj.1	+	2	1586	c.1431C>T	c.(1429-1431)CGC>CGT	p.R477R	CORO7_uc002cwe.2_Intron|CORO7_uc002cwf.2_Intron|CORO7_uc002cwg.3_Intron|CORO7_uc002cwh.3_Intron|CORO7_uc010uxh.1_Intron|CORO7_uc010uxi.1_Intron|CORO7_uc002cwi.1_Intron|CORO7_uc010uxj.1_Intron|CORO7_uc010btp.1_Intron	NM_138440	NP_612449	Q6EMK4	VASN_HUMAN	slit-like 2 precursor	477	Fibronectin type-III.|Extracellular (Potential).					extracellular region|integral to membrane					0						CCTCCCTGCGCGTGGGGCTGC	0.692000													6	12					0	0	1	0	0	
GLYR1	84656	broad.mit.edu	37	16	4862113	4862113	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:4862113G>A	uc002cxx.3	-	13	1293	c.1256C>T	c.(1255-1257)GCG>GTG	p.A419V	GLYR1_uc002cxy.2_RNA|GLYR1_uc002cxz.1_Missense_Mutation_p.A333V|GLYR1_uc002cya.2_Missense_Mutation_p.A413V|GLYR1_uc010uxv.1_Missense_Mutation_p.A338V	NM_032569	NP_115958	Q49A26	GLYR1_HUMAN	cytokine-like nuclear factor n-pac	419				A -> T (in Ref. 7; AAH47223).	pentose-phosphate shunt	nucleus	coenzyme binding|DNA binding|methylated histone residue binding|phosphogluconate dehydrogenase (decarboxylating) activity				0						CTTCCCCATCGCCTGGAAGCA	0.572000													25	32					0	0	1	0	0	
GRIN2A	2903	broad.mit.edu	37	16	9858350	9858350	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:9858350G>A	uc002czo.3	-	13	3599	c.3051C>T	c.(3049-3051)TCC>TCT	p.S1017S	GRIN2A_uc010uym.1_Silent_p.S1017S|GRIN2A_uc010uyn.1_Silent_p.S860S|GRIN2A_uc002czr.3_Silent_p.S1017S	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1017	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGAATCCACGGATTTCTTCC	0.532000													41	59					0	0	1	0	0	
GRIN2A	2903	broad.mit.edu	37	16	9943710	9943710	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:9943710G>T	uc002czo.3	-	5	1779	c.1231C>A	c.(1231-1233)CTG>ATG	p.L411M	GRIN2A_uc010uym.1_Missense_Mutation_p.L411M|GRIN2A_uc010uyn.1_Missense_Mutation_p.L254M|GRIN2A_uc002czr.3_Missense_Mutation_p.L411M	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	411	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GCCTCCTCCAGGGTGACGATG	0.577000													38	58					2.40579e-17	2.56709e-17	1	1	0	
TXNDC11	51061	broad.mit.edu	37	16	11829888	11829888	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:11829888A>G	uc010buu.1	-	2	518	c.456T>C	c.(454-456)AGT>AGC	p.S152S	TXNDC11_uc002dbg.1_Silent_p.S152S	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	152	Thioredoxin 1.				cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						CTGAAAGCCGACTTGCTGCTT	0.502000													5	85					0	0	1	0	0	
RSL1D1	26156	broad.mit.edu	37	16	11933615	11933615	+	Silent	SNP	G	A	A	rs144452977	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:11933615G>A	uc002dbp.1	-	8	1156	c.1083C>T	c.(1081-1083)TCC>TCT	p.S361S	RSL1D1_uc010buv.1_Silent_p.S360S|RSL1D1_uc010uyw.1_Silent_p.S141S|RSL1D1_uc010buw.2_RNA	NM_015659	NP_056474	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	361					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						TTTCGTCTTCGGATTCATTTG	0.398000													58	103					0	0	1	0	0	
KIAA0430	9665	broad.mit.edu	37	16	15710928	15710928	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:15710928C>T	uc002ddr.2	-	15	3251	c.3058G>A	c.(3058-3060)GGC>AGC	p.G1020S	KIAA0430_uc002ddq.2_Missense_Mutation_p.G854S|KIAA0430_uc010uzv.1_Missense_Mutation_p.G1016S|KIAA0430_uc010uzw.1_Missense_Mutation_p.G1019S	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1019						peroxisome	nucleotide binding|RNA binding				0						GGCACGGTGCCCTCGTGGGTC	0.458000													34	50					0	0	1	0	0	
MYH11	4629	broad.mit.edu	37	16	15847322	15847322	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:15847322G>A	uc002ddy.2	-	15	1900	c.1793C>T	c.(1792-1794)CCG>CTG	p.P598L	MYH11_uc002ddv.2_Missense_Mutation_p.P605L|MYH11_uc002ddw.2_Missense_Mutation_p.P598L|MYH11_uc002ddx.2_Missense_Mutation_p.P605L|MYH11_uc010bvg.2_Missense_Mutation_p.P430L|MYH11_uc002dea.1_Missense_Mutation_p.P304L	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	598	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GTCATTCAGCGGGTCCATATT	0.537000			T	CBFB	AML								22	48					0	0	1	0	0	
ABCC1	4363	broad.mit.edu	37	16	16200615	16200615	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:16200615C>A	uc010bvi.2	+	21	2931	c.2756C>A	c.(2755-2757)TCC>TAC	p.S919Y	ABCC1_uc010bvj.2_Missense_Mutation_p.S860Y|ABCC1_uc010bvk.2_Missense_Mutation_p.S863Y|ABCC1_uc010bvl.2_Missense_Mutation_p.S919Y|ABCC1_uc010bvm.2_Missense_Mutation_p.S804Y|ABCC1_uc002del.3_Missense_Mutation_p.S813Y	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	919	Cytoplasmic.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AGCTCCTCCTCCTATAGTGGG	0.577000													31	46					5.09552e-08	5.25948e-08	1	1	0	
Unknown	0	broad.mit.edu	37	16	16468218	16468218	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:16468218C>A	uc002dey.2	+	5	1136	c.849C>A	c.(847-849)GCC>GCA	p.A283A						SubName: Full=cDNA FLJ42525 fis, clone BRACE3001391, highly similar to Polycystin;																		GTACCACGGCCCACGTGGGCA	0.652000													13	18					0.00316338	0.00319607	1	1	0	
GPR139	124274	broad.mit.edu	37	16	20084857	20084857	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:20084857C>T	uc002dgu.1	-	1	244	c.82G>A	c.(82-84)GTG>ATG	p.V28M	GPR139_uc010vaw.1_Translation_Start_Site	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	28	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(2)	2						ACCACGGGCACGAAACCCAAG	0.682000													7	8					0	0	1	0	0	
PDILT	204474	broad.mit.edu	37	16	20380898	20380898	+	Silent	SNP	G	A	A	rs150342728	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:20380898G>A	uc002dhc.1	-	8	1255	c.1032C>T	c.(1030-1032)GAC>GAT	p.D344D		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	344					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TGTACCTGGCGTCAGAGCTCA	0.468000													63	88					0	0	1	0	0	
LOC100132247	100132247	broad.mit.edu	37	16	22545865	22545865	+	Missense_Mutation	SNP	G	C	C	rs147500263	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:22545865G>C	uc010bxg.2	+	9	1743	c.1561G>C	c.(1561-1563)GCC>CCC	p.A521P	LOC100132247_uc010vbv.1_Missense_Mutation_p.A521P|LOC100132247_uc010vbw.1_Intron|LOC100132247_uc010bxi.2_Missense_Mutation_p.A502P|LOC100132247_uc010bxk.2_Missense_Mutation_p.A338P|uc010vbx.1_5'Flank	NM_001135865	NP_001129337	A8MRT5	K220L_HUMAN	hypothetical protein LOC100132247	521	Pro-rich.					integral to membrane					0						TCAGCTCACTGCCCTTCCACC	0.567000													44	313					0	0	1	0	0	
ERN2	10595	broad.mit.edu	37	16	23713538	23713538	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:23713538G>A	uc002dma.3	-	11	1451	c.1282C>T	c.(1282-1284)CTG>TTG	p.L428L	ERN2_uc010bxp.2_Silent_p.L428L|ERN2_uc010bxq.1_Silent_p.L236L	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	380	Lumenal (Potential).			L -> P (in Ref. 1; BAB21297).	apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CCACTCCCCAGGGTGGGATGG	0.607000													41	83					0	0	1	0	0	
ERN2	10595	broad.mit.edu	37	16	23716327	23716327	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:23716327G>A	uc002dma.3	-	8	1044	c.875C>T	c.(874-876)CCG>CTG	p.P292L	ERN2_uc010bxp.2_Missense_Mutation_p.P292L|ERN2_uc010bxq.1_Missense_Mutation_p.P100L	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	244	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CGTGAGATGCGGCAGCTGGCG	0.677000													26	43					0	0	1	0	0	
PRKCB	5579	broad.mit.edu	37	16	24192209	24192209	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:24192209C>T	uc002dmd.2	+	13	1690	c.1493C>T	c.(1492-1494)ACC>ATC	p.T498I	PRKCB_uc002dme.2_Missense_Mutation_p.T498I	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	498	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	GGGGTGACAACCAAGACATTC	0.522000													38	59					0	0	1	0	0	
RBBP6	5930	broad.mit.edu	37	16	24582742	24582742	+	Missense_Mutation	SNP	C	T	T	rs138495629	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:24582742C>T	uc002dmh.2	+	18	5395	c.4355C>T	c.(4354-4356)ACG>ATG	p.T1452M	RBBP6_uc002dmi.2_Missense_Mutation_p.T1418M|RBBP6_uc010bxr.2_Missense_Mutation_p.T612M|RBBP6_uc002dmk.2_Missense_Mutation_p.T1285M	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1452	Interaction with p53 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GAGGCTAGAACGTCAGATAAA	0.398000													20	41					0	0	1	0	0	
GTF3C1	2975	broad.mit.edu	37	16	27561201	27561201	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:27561201A>G	uc002dov.1	-	1	51	c.11T>C	c.(10-12)CTG>CCG	p.L4P	GTF3C1_uc002dou.2_Missense_Mutation_p.L4P|KIAA0556_uc002dow.2_5'Flank	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	4						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CAACGACTCCAGCGCGTCCAT	0.697000													10	15					0	0	1	0	0	
CD19	930	broad.mit.edu	37	16	28948671	28948671	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:28948671C>T	uc002drs.2	+	9	1340	c.1278C>T	c.(1276-1278)AAC>AAT	p.N426N	uc010vct.1_Intron|CD19_uc010byo.1_Silent_p.N426N	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	426	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						ACGACTCCAACCTTGGGCAGG	0.632000													22	32					0	0	1	0	0	
NFATC2IP	84901	broad.mit.edu	37	16	28967620	28967620	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:28967620C>T	uc002dru.2	+	5	823	c.808C>T	c.(808-810)CGT>TGT	p.R270C	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Intron|NFATC2IP_uc002drv.2_5'UTR|NFATC2IP_uc010vdh.1_5'Flank	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	270						cytoplasm|nucleus				ovary(1)	1						ACTCAAAATCCGTTGCCGGGC	0.612000													13	28					0	0	1	0	0	
SEZ6L2	26470	broad.mit.edu	37	16	29884960	29884960	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:29884960C>T	uc002duq.3	-	13	2435	c.2195G>A	c.(2194-2196)CGC>CAC	p.R732H	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.R662H|SEZ6L2_uc002dur.3_Missense_Mutation_p.R662H|SEZ6L2_uc002dus.3_Missense_Mutation_p.R618H|SEZ6L2_uc010vec.1_Missense_Mutation_p.R732H|SEZ6L2_uc010ved.1_Missense_Mutation_p.R688H	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	732	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						TGGCAGGCAGCGGTACTGGAC	0.667000													20	24					0	0	1	0	0	
TAOK2	9344	broad.mit.edu	37	16	29997691	29997691	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:29997691C>T	uc002dva.1	+	16	2881	c.2098C>T	c.(2098-2100)CGC>TGC	p.R700C	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.R700C|TAOK2_uc002dvc.1_Missense_Mutation_p.R700C|TAOK2_uc010bzm.1_Missense_Mutation_p.R707C|TAOK2_uc002dvd.1_Missense_Mutation_p.R527C	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	700	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GGCCGTGCAGCGCACGCGGGC	0.652000													32	37					0	0	1	0	0	
ZNF689	115509	broad.mit.edu	37	16	30616334	30616334	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:30616334G>A	uc002dyx.2	-	3	1074	c.754C>T	c.(754-756)CGG>TGG	p.R252W	ZNF689_uc010bzy.2_5'UTR	NM_138447	NP_612456	Q96CS4	ZN689_HUMAN	zinc finger protein HIT-39	252	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			Colorectal(24;0.198)			TGTGTGGTCCGGTGATTGGCC	0.617000													28	51					0	0	1	0	0	
PHKG2	5261	broad.mit.edu	37	16	30767987	30767987	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:30767987G>A	uc002dzk.1	+	9	971	c.878G>A	c.(877-879)CGT>CAT	p.R293H	PHKG2_uc002dzi.1_Missense_Mutation_p.R297H|PHKG2_uc002dzj.1_Missense_Mutation_p.R191H	NM_000294	NP_000285	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	293					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)			TTCTTTGAGCGTTGTGAAGGC	0.607000													31	48					0	0	1	0	0	
ZNF646	9726	broad.mit.edu	37	16	31089180	31089180	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:31089180G>A	uc002eap.2	+	2	1824	c.1535G>A	c.(1534-1536)CGG>CAG	p.R512Q		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	512	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						AACCACGTGCGGGTACATTGC	0.627000													4	25					0	0	1	0	0	
MYST1	84148	broad.mit.edu	37	16	31131804	31131804	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:31131804G>A	uc002eay.2	+	3	449	c.431G>A	c.(430-432)CGC>CAC	p.R144H	MYST1_uc002eax.2_Missense_Mutation_p.R144H	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	144					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						AACCAAAAGCGCAAGCATGAT	0.567000													11	17					0	0	1	0	0	
PRSS36	146547	broad.mit.edu	37	16	31154777	31154777	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:31154777G>T	uc002ebd.2	-	8	1045	c.986C>A	c.(985-987)CCG>CAG	p.P329Q	PRSS36_uc010vff.1_Missense_Mutation_p.P104Q|PRSS36_uc010vfg.1_Missense_Mutation_p.P329Q|PRSS36_uc010vfh.1_Missense_Mutation_p.P329Q	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	329	Peptidase S1 2.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CCCTGGCCGCGGGGCCTTCCC	0.667000													17	26					5.03518e-11	5.27141e-11	1	1	0	
ITGAM	3684	broad.mit.edu	37	16	31309156	31309156	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:31309156G>A	uc002ebq.2	+	14	1686	c.1588G>A	c.(1588-1590)GTA>ATA	p.V530I	ITGAM_uc002ebr.2_Missense_Mutation_p.V531I|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Intron	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	530	FG-GAP 6.|Extracellular (Potential).|Potential.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GCTGGGGGACGTAAATGGGGA	0.612000													36	59					0	0	1	0	0	
N4BP1	9683	broad.mit.edu	37	16	48585361	48585361	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:48585361C>T	uc002efp.2	-	4	2290	c.2053G>A	c.(2053-2055)GGA>AGA	p.G685R		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	685					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				GATAATATTCCGAGCTCCTGG	0.413000													51	77					0	0	1	0	0	
SNX20	124460	broad.mit.edu	37	16	50707922	50707922	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:50707922G>A	uc002egk.2	-	4	519	c.346C>T	c.(346-348)CGC>TGC	p.R116C	SNX20_uc010vgp.1_Intron|SNX20_uc002egi.3_Intron	NM_182854	NP_878274	Q7Z614	SNX20_HUMAN	sorting nexin 20 isoform 1	116	PX.	Phosphatidylinositol 3-phosphate (By similarity).		R->Q: Decreased binding activity to all phospholipids.	cell communication|protein transport	endosome membrane|nucleus|plasma membrane	phosphatidylinositol binding|protein binding			ovary(1)	1						TCGGAATAGCGCCGTTCCAGG	0.567000													24	44					0	0	1	0	0	
CYLD	1540	broad.mit.edu	37	16	50826538	50826538	+	Nonsense_Mutation	SNP	C	T	T	rs121908388		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:50826538C>T	uc002egp.1	+	16	2687	c.2272C>T	c.(2272-2274)CGA>TGA	p.R758*	CYLD_uc010cbs.1_Nonsense_Mutation_p.R755*|CYLD_uc002egq.1_Nonsense_Mutation_p.R755*|CYLD_uc002egr.1_Nonsense_Mutation_p.R755*	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	758					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.R758*(2)		skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				TCAGATGCCTCGATTTGGAAA	0.264000			Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				6	13					0	0	1	0	0	
RBL2	5934	broad.mit.edu	37	16	53501054	53501054	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:53501054C>T	uc002ehi.3	+	14	2066	c.1948C>T	c.(1948-1950)CGT>TGT	p.R650C	RBL2_uc010vgv.1_Missense_Mutation_p.R576C|RBL2_uc002ehj.2_Missense_Mutation_p.R360C|RBL2_uc010vgw.1_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	650	Spacer.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GACTGAAGTTCGTGCTGATAC	0.423000													56	86					0	0	1	0	0	
MMP2	4313	broad.mit.edu	37	16	55522591	55522591	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:55522591C>T	uc002ehz.3	+	6	1280	c.969C>T	c.(967-969)TAC>TAT	p.Y323Y	MMP2_uc010vhd.1_Silent_p.Y247Y|MMP2_uc010ccc.2_Silent_p.Y273Y	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	323	Fibronectin type-II 2.|Collagen-binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CTGAGGACTACGACCGCGACA	0.602000													5	6					0	0	1	0	0	
FAM192A	80011	broad.mit.edu	37	16	57201038	57201038	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:57201038G>A	uc010vhk.1	-	5	708	c.449C>T	c.(448-450)GCG>GTG	p.A150V	FAM192A_uc002ekz.3_Missense_Mutation_p.A149V|FAM192A_uc002ekv.3_Missense_Mutation_p.A72V|FAM192A_uc002ekw.3_Missense_Mutation_p.A149V|FAM192A_uc002ekx.3_Missense_Mutation_p.A149V|FAM192A_uc002eky.3_Missense_Mutation_p.A149V	NM_024946	NP_079222	Q9GZU8	F192A_HUMAN	NEFA-interacting nuclear protein NIP30	150						nucleus					0						CAACAGCTTCGCCTGGGAGAA	0.438000													64	88					0	0	1	0	0	
CNGB1	1258	broad.mit.edu	37	16	57935308	57935308	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:57935308A>G	uc002emt.2	-	29	2989	c.2924T>C	c.(2923-2925)CTG>CCG	p.L975P	CNGB1_uc010cdh.2_Missense_Mutation_p.L969P	NM_001297	NP_001288	Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1 isoform	975	Helical; Name=H6; (Potential).|cAMP (By similarity).				sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)|pancreas(1)	4						AAGCCTCTTCAGCATGTCAAA	0.572000													43	88					0	0	1	0	0	
TPPP3	51673	broad.mit.edu	37	16	67424238	67424238	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:67424238G>A	uc002esz.2	-	3	1205	c.370C>T	c.(370-372)CGG>TGG	p.R124W	TPPP3_uc002eta.2_Missense_Mutation_p.R124W|TPPP3_uc002etb.2_Missense_Mutation_p.R124W	NM_016140	NP_057224	Q9BW30	TPPP3_HUMAN	tubulin polymerization-promoting protein family	124					microtubule bundle formation	cytoplasm|microtubule	calcium ion binding|tubulin binding			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0336)|Epithelial(162;0.0781)		TCCGTCAGCCGGTCTACAGCA	0.617000													75	87					0	0	1	0	0	
HSD11B2	3291	broad.mit.edu	37	16	67470747	67470747	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:67470747C>T	uc002etd.2	+	5	1175	c.1059C>T	c.(1057-1059)TAC>TAT	p.Y353Y		NM_000196	NP_000187	P80365	DHI2_HUMAN	hydroxysteroid (11-beta) dehydrogenase 2	353					glucocorticoid biosynthetic process	endoplasmic reticulum|microsome					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0401)|Epithelial(162;0.0891)	NADH(DB00157)	TCCACTACTACCTGCCTGAAG	0.642000													53	88					0	0	1	0	0	
CTCF	10664	broad.mit.edu	37	16	67670706	67670706	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:67670706C>T	uc002etl.2	+	11	2241	c.1951C>T	c.(1951-1953)CGG>TGG	p.R651W	CTCF_uc010cek.2_Missense_Mutation_p.R323W|CTCF_uc002etm.1_Missense_Mutation_p.R140W	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	651					chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		CGCCAAGAAGCGGAGAGGACG	0.592000													60	159					0	0	1	0	0	
CENPT	80152	broad.mit.edu	37	16	67865197	67865197	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:67865197G>A	uc002eun.3	-	10	1174	c.625C>T	c.(625-627)CGC>TGC	p.R209C	CENPT_uc002eum.3_Missense_Mutation_p.R209C|CENPT_uc010vkc.1_5'UTR|CENPT_uc010vkd.1_5'UTR|CENPT_uc010vke.1_Missense_Mutation_p.R106C	NM_025082	NP_079358	Q96BT3	CENPT_HUMAN	centromere protein T	209					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		GGAGGTCTGCGGGCCAAGCCA	0.597000													18	30					0	0	1	0	0	
SMPD3	55512	broad.mit.edu	37	16	68395144	68395144	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:68395144G>A	uc002ewa.2	-	9	2355	c.1933C>T	c.(1933-1935)CGA>TGA	p.R645*	SMPD3_uc010cfe.2_Nonsense_Mutation_p.R628*|SMPD3_uc010vlh.1_Nonsense_Mutation_p.R637*	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	645	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	ACCATCAGTCGCATGGCTACT	0.637000													13	8					0	0	1	0	0	
SMPD3	55512	broad.mit.edu	37	16	68405487	68405487	+	Missense_Mutation	SNP	C	T	T	rs149257689		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:68405487C>T	uc002ewa.2	-	3	1020	c.598G>A	c.(598-600)GTC>ATC	p.V200I	SMPD3_uc010cfe.2_Missense_Mutation_p.V200I|SMPD3_uc010vlh.1_Missense_Mutation_p.V200I	NM_018667	NP_061137	Q9NY59	NSMA2_HUMAN	neutral sphingomyelin phosphodiesterase 3	200	Lumenal (Potential).				cell cycle|multicellular organismal development|sphingomyelin catabolic process	Golgi membrane|integral to membrane|plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity			skin(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0184)|Epithelial(162;0.0785)	Phosphatidylserine(DB00144)	CTCCCGGGGACGGCCCGGGCC	0.652000													14	19					0	0	1	0	0	
CDH3	1001	broad.mit.edu	37	16	68713830	68713830	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:68713830C>T	uc002ewf.2	+	7	1952	c.820C>T	c.(820-822)CGG>TGG	p.R274W	CDH3_uc010vli.1_Missense_Mutation_p.R219W	NM_001793	NP_001784	P22223	CADH3_HUMAN	cadherin 3, type 1 preproprotein	274	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(1)		ovary(3)|breast(1)|skin(1)	5		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CACCATTCACCGGAGCACAGG	0.557000													32	38					0	0	1	0	0	
TMCO7	79613	broad.mit.edu	37	16	68941412	68941412	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:68941412C>T	uc002ewi.3	+	10	1746	c.1734C>T	c.(1732-1734)CTC>CTT	p.L578L		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	578						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TGGAGCATCTCGGGGACTTGC	0.488000													27	40					0	0	1	0	0	
TMCO7	79613	broad.mit.edu	37	16	69117396	69117396	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:69117396C>T	uc002ewi.3	+	18	3129	c.3117C>T	c.(3115-3117)AGC>AGT	p.S1039S		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	1039						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		AGGTGCTGAGCGCCGTCCTCA	0.587000													6	10					0	0	1	0	0	
MTSS1L	92154	broad.mit.edu	37	16	70712206	70712206	+	Silent	SNP	G	A	A	rs3813907		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:70712206G>A	uc002ezj.2	-	8	833	c.573C>T	c.(571-573)ATC>ATT	p.I191I	MTSS1L_uc002ezk.1_Silent_p.I108I	NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	191	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						CCCGCTCCTCGATCAGCGCCC	0.677000													35	60					0	0	1	0	0	
DHX38	9785	broad.mit.edu	37	16	72141380	72141380	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:72141380G>A	uc002fcb.2	+	20	3097	c.2742G>A	c.(2740-2742)CCG>CCA	p.P914P	DHX38_uc010vmp.1_Silent_p.P226P	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	914					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				TCATGGACCCGCCCCCGGAGG	0.632000													15	26					0	0	1	0	0	
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:72821615G>A	uc002fck.2	-	10	11233	c.10560C>T	c.(10558-10560)GGC>GGT	p.G3520G	uc002fcj.1_RNA|ZFHX3_uc002fcl.2_Silent_p.G2606G	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.408000													5	22					0	0	1	0	0	
LOC283922	283922	broad.mit.edu	37	16	74372644	74372644	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:74372644A>G	uc002fcr.2	-	9	1661	c.315T>C	c.(313-315)CCT>CCC	p.P105P	LOC283922_uc010vms.1_RNA					Homo sapiens cDNA FLJ39449 fis, clone PROST2008360, highly similar to Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.												0						TACCCTTGTCAGGGGGAACAA	0.443000													9	41					0	0	1	0	0	
CNTNAP4	85445	broad.mit.edu	37	16	76528929	76528929	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:76528929T>C	uc002feu.1	+	16	2588	c.2203T>C	c.(2203-2205)TAT>CAT	p.Y735H	CNTNAP4_uc002fev.1_Missense_Mutation_p.Y599H|CNTNAP4_uc010chb.1_Missense_Mutation_p.Y662H|CNTNAP4_uc002fex.1_Missense_Mutation_p.Y738H|CNTNAP4_uc002few.2_Missense_Mutation_p.Y710H	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	735	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TGATTCTCAGTATTACTGCAA	0.363000													43	90					0	0	1	0	0	
ADAMTS18	170692	broad.mit.edu	37	16	77369733	77369733	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:77369733G>A	uc002ffc.3	-	12	2198	c.1779C>T	c.(1777-1779)TCC>TCT	p.S593S	ADAMTS18_uc010chc.1_Silent_p.S181S|ADAMTS18_uc002ffe.1_Silent_p.S289S	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	593	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TCGACCAGGCGGACCACTGGC	0.572000													76	132					0	0	1	0	0	
MBTPS1	8720	broad.mit.edu	37	16	84129294	84129294	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:84129294G>A	uc002fhi.2	-	4	1040	c.538C>T	c.(538-540)CAT>TAT	p.H180Y		NM_003791	NP_003782	Q14703	MBTP1_HUMAN	membrane-bound transcription factor site-1	180					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			ovary(2)	2						CTGCTCGAATGCCTTCCCGTA	0.592000													60	83					0	0	1	0	0	
FOXF1	2294	broad.mit.edu	37	16	86544636	86544636	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:86544636T>C	uc002fjl.2	+	1	504	c.461T>C	c.(460-462)ATG>ACG	p.M154T	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	154					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0						CTCAAGCCCATGTACAGCATG	0.672000													27	57					0	0	1	0	0	
JPH3	57338	broad.mit.edu	37	16	87678038	87678038	+	Missense_Mutation	SNP	C	T	T	rs142120839	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:87678038C>T	uc002fkd.2	+	2	811	c.557C>T	c.(556-558)GCC>GTC	p.A186V	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	186	Cytoplasmic (Potential).			A -> D (in Ref. 1; BAB11983).	calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		CCGGCGGTGGCCGGCAGCCCG	0.697000													7	92					0	0	1	0	0	
C16orf7	9605	broad.mit.edu	37	16	89777020	89777021	+	Missense_Mutation	DNP	GC	AT	AT			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:89777020_89777021GC>AT	uc002fom.1	-	10	1356_1357	c.1231_1232GC>AT	c.(1231-1233)GCG>ATG	p.A411M	C16orf7_uc002fol.1_Missense_Mutation_p.A341M|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	411					ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CTCCTCCACCGCGGTCTTCAGC	0.658000													21	11					0	0	1	0	0	
SCARF1	8578	broad.mit.edu	37	17	1548210	1548210	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:1548210G>A	uc002fsz.1	-	3	233	c.183C>T	c.(181-183)GAC>GAT	p.D61D	SCARF1_uc002fsy.1_Silent_p.D61D|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Silent_p.D61D	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	61	EGF-like 1.|Extracellular (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TCTGGCAGGCGTCCGGCCCCT	0.642000													11	19					0	0	1	0	0	
WDR81	124997	broad.mit.edu	37	17	1637421	1637421	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:1637421G>A	uc002fti.2	+	7	1670	c.1409G>A	c.(1408-1410)CGC>CAC	p.R470H	WDR81_uc002fth.2_Missense_Mutation_p.R646H|WDR81_uc010vqp.1_Missense_Mutation_p.R494H|WDR81_uc002ftj.2_Missense_Mutation_p.R1697H|WDR81_uc010vqq.1_Missense_Mutation_p.R328H	NM_001163811	NP_001157283	Q562E7	WDR81_HUMAN	WD repeat domain 81 isoform 4	470										skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		ACCCAGCACCGCAAGAGCGTC	0.677000													20	28					0	0	1	0	0	
KIAA0664	23277	broad.mit.edu	37	17	2597526	2597526	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:2597526C>T	uc002fuy.1	-	18	2951	c.2865G>A	c.(2863-2865)GCG>GCA	p.A955A	KIAA0664_uc002fux.1_Silent_p.A888A|KIAA0664_uc010ckc.1_5'UTR	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	955							binding			breast(2)	2						CCTCGGTGAACGCGGGCTTGT	0.637000													7	10					0	0	1	0	0	
ITGAE	3682	broad.mit.edu	37	17	3651333	3651333	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:3651333C>T	uc002fwo.3	-	17	2137	c.2038G>A	c.(2038-2040)GTT>ATT	p.V680I		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	680	FG-GAP 7.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TTCAGGCGAACCACAGGCCGG	0.512000													10	23					0	0	1	0	0	
CAMTA2	23125	broad.mit.edu	37	17	4880409	4880409	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:4880409C>T	uc002gah.1	-	11	1952	c.1844G>A	c.(1843-1845)CGA>CAA	p.R615Q	CAMTA2_uc010cku.1_Missense_Mutation_p.R638Q|CAMTA2_uc002gag.1_Missense_Mutation_p.R614Q|CAMTA2_uc002gai.1_Missense_Mutation_p.R617Q|CAMTA2_uc010ckv.1_Missense_Mutation_p.R262Q	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	615	IPT/TIG.				cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						TCGGCGGGCTCGATACTCAAA	0.592000													43	60					0	0	1	0	0	
CAMTA2	23125	broad.mit.edu	37	17	4886166	4886166	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:4886166G>A	uc002gah.1	-	5	333	c.225C>T	c.(223-225)ATC>ATT	p.I75I	CAMTA2_uc010cku.1_Silent_p.I98I|CAMTA2_uc002gag.1_Silent_p.I98I|CAMTA2_uc002gai.1_Silent_p.I77I|CAMTA2_uc010ckv.1_5'Flank|CAMTA2_uc010vsu.1_5'UTR	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	75	CG-1.				cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GATTGTAGAGGATGATGGAGC	0.537000													31	54					0	0	1	0	0	
BCL6B	255877	broad.mit.edu	37	17	6930069	6930069	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:6930069G>A	uc002geg.2	+	7	1157	c.1100G>A	c.(1099-1101)CGG>CAG	p.R367Q	BCL6B_uc010clt.1_Missense_Mutation_p.R368Q	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	367	C2H2-type 2.					nucleus	zinc ion binding			skin(1)	1						CGTTTTAACCGGCCAGCAAAC	0.572000													42	72					0	0	1	0	0	
C17orf74	201243	broad.mit.edu	37	17	7329696	7329696	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:7329696G>A	uc002ggw.2	+	3	459	c.386G>A	c.(385-387)CGC>CAC	p.R129H	FGF11_uc010vtw.1_Intron	NM_175734	NP_783861	Q0P670	CQ074_HUMAN	hypothetical protein LOC201243	129	Arg-rich.					integral to membrane					0		Prostate(122;0.157)				cgccgccgccgccgccaccgc	0.413000													26	48					0	0	1	0	0	
ZBTB4	57659	broad.mit.edu	37	17	7365565	7365565	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:7365565A>G	uc002ghc.3	-	4	2986	c.2736T>C	c.(2734-2736)GCT>GCC	p.A912A	ZBTB4_uc002ghd.3_Silent_p.A912A	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	912					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		TGACTTTGGCAGCCCCTATCC	0.642000													59	86					0	0	1	0	0	
TRAPPC1	58485	broad.mit.edu	37	17	7833935	7833935	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:7833935G>A	uc002gjo.1	-	4	543	c.427C>T	c.(427-429)CGG>TGG	p.R143W	KCNAB3_uc002gjm.1_5'Flank|KCNAB3_uc010vul.1_5'Flank|CNTROB_uc002gjp.2_5'Flank|CNTROB_uc002gjq.2_5'Flank	NM_021210	NP_067033	Q9Y5R8	TPPC1_HUMAN	trafficking protein particle complex 1	143					ER to Golgi vesicle-mediated transport	endoplasmic reticulum					0		Prostate(122;0.173)				CAGCCAGCCCGGGCGGAGAAG	0.597000													21	25					0	0	1	0	0	
ALOX12B	242	broad.mit.edu	37	17	7976235	7976235	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:7976235C>T	uc002gjy.1	-	15	2221	c.1960G>A	c.(1960-1962)GTG>ATG	p.V654M		NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	654	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						GCCTCCTCCACGAAGTGAATG	0.682000										Multiple Myeloma(8;0.094)			16	20					0	0	1	0	0	
PFAS	5198	broad.mit.edu	37	17	8172397	8172397	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:8172397C>A	uc002gkr.2	+	28	3973	c.3832C>A	c.(3832-3834)CCA>ACA	p.P1278T	PFAS_uc010vuv.1_Missense_Mutation_p.P854T|PFAS_uc002gks.2_3'UTR	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	1278	Glutamine amidotransferase type-1.				'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CAATGGGTCCCCAGGGGGCGT	0.642000													32	53					4.00102e-26	4.31866e-26	1	1	0	
ARHGEF15	22899	broad.mit.edu	37	17	8219412	8219412	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:8219412G>A	uc002glc.2	+	9	1771	c.1650G>A	c.(1648-1650)CCG>CCA	p.P550P	ARHGEF15_uc002gld.2_Silent_p.P550P|ARHGEF15_uc010vuw.1_Silent_p.P439P	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	550	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						TCCCGCTGCCGTCCTTCCTGC	0.677000													5	11					0	0	1	0	0	
MYH10	4628	broad.mit.edu	37	17	8408178	8408178	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:8408178G>A	uc002gll.2	-	26	3436	c.3340C>T	c.(3340-3342)CGA>TGA	p.R1114*	MYH10_uc002glm.2_Nonsense_Mutation_p.R1145*|MYH10_uc010cnx.2_Nonsense_Mutation_p.R1123*	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1114	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TGTAGCTCTCGCACAACTTTA	0.493000													11	147					0	0	1	0	0	
MFSD6L	162387	broad.mit.edu	37	17	8700837	8700837	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:8700837C>T	uc002glp.1	-	1	1750	c.1602G>A	c.(1600-1602)TGG>TGA	p.W534*		NM_152599	NP_689812	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing	534	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1						GCAAGGCCAACCAGAGCAACA	0.607000													22	36					0	0	1	0	0	
WDR16	146845	broad.mit.edu	37	17	9489257	9489257	+	Missense_Mutation	SNP	G	A	A	rs141718755	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:9489257G>A	uc002gly.2	+	2	307	c.238G>A	c.(238-240)GCC>ACC	p.A80T	WDR16_uc002glz.2_Intron|WDR16_uc010coc.2_Missense_Mutation_p.A90T	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	80	WD 1.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						AGAGTACATCGCCTCCGGACA	0.478000													37	70					0	0	1	0	0	
DHRS7C	201140	broad.mit.edu	37	17	9694592	9694592	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:9694592T>C	uc010vvb.1	-	1	10	c.10A>G	c.(10-12)ATG>GTG	p.M4V	DHRS7C_uc010cof.2_Missense_Mutation_p.M4V	NM_001105571	NP_001099041	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	4						extracellular region	binding|oxidoreductase activity				0						AGCATGGCCATGACTCCCATC	0.577000													11	12					0	0	1	0	0	
MYH4	4622	broad.mit.edu	37	17	10348335	10348335	+	Silent	SNP	C	T	T	rs141762664		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:10348335C>T	uc002gmn.2	-	37	5535	c.5424G>A	c.(5422-5424)GCG>GCA	p.A1808A	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	1808	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CACCCTTCAGCGCCAGCTGCT	0.557000													46	92					0	0	1	0	0	
MYH3	4621	broad.mit.edu	37	17	10533718	10533718	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:10533718G>A	uc002gmq.1	-	36	5421	c.5344C>T	c.(5344-5346)CGG>TGG	p.R1782W		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1782	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TTCTTCATCCGCTCAAGGTGG	0.577000													43	90					0	0	1	0	0	
MYH3	4621	broad.mit.edu	37	17	10533732	10533732	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:10533732C>T	uc002gmq.1	-	36	5407	c.5330G>A	c.(5329-5331)AGC>AAC	p.S1777N		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1777	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						AAGGTGGGCGCTGGTGTCCTG	0.587000													38	93					0	0	1	0	0	
MAP2K4	6416	broad.mit.edu	37	17	12011144	12011144	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:12011144C>T	uc002gnj.2	+	5	620	c.551C>T	c.(550-552)TCG>TTG	p.S184L	MAP2K4_uc002gnk.2_Missense_Mutation_p.S195L|MAP2K4_uc010vvi.1_Missense_Mutation_p.S66L|MAP2K4_uc010vvj.1_Missense_Mutation_p.S56L	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4	184	Protein kinase.				cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.S184L(2)|p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		ATGTCTACCTCGTTTGATAAG	0.299000			D|Mis|N		pancreatic|breast|colorectal								44	87					0	0	1	0	0	
TRIM16	10626	broad.mit.edu	37	17	15532407	15532407	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:15532407G>A	uc002gox.2	-	9	1774	c.1217C>T	c.(1216-1218)CCG>CTG	p.P406L	TRIM16_uc002gor.1_Missense_Mutation_p.P406L|TRIM16_uc002gow.2_Missense_Mutation_p.P190L|TRIM16_uc002goy.2_Missense_Mutation_p.P276L	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	406	B30.2/SPRY.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		GGGGAGGTCCGGGTAGGGATG	0.597000													11	26					0	0	1	0	0	
TRIM16	10626	broad.mit.edu	37	17	15554526	15554526	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:15554526G>A	uc002gox.2	-	4	955	c.398C>T	c.(397-399)GCC>GTC	p.A133V	TRIM16_uc002gor.1_Missense_Mutation_p.A133V|TRIM16_uc002goy.2_Intron	NM_006470	NP_006461	O95361	TRI16_HUMAN	tripartite motif-containing 16	133	B box-type 2.				histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		GCTGTGGTGGGCAGGGCAGTA	0.577000													26	36					0	0	1	0	0	
RAI1	10743	broad.mit.edu	37	17	17698048	17698048	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:17698048C>T	uc002grm.2	+	3	2255	c.1786C>T	c.(1786-1788)CGG>TGG	p.R596W	RAI1_uc002grn.1_Missense_Mutation_p.R596W	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	596						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GGACTGTCCGCGGCTGCTGCT	0.637000													20	54					0	0	1	0	0	
MYO15A	51168	broad.mit.edu	37	17	18023050	18023050	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:18023050C>T	uc010vxh.1	+	2	1274	c.936C>T	c.(934-936)TAC>TAT	p.Y312Y		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	312	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					ACGACGATTACGAACCCCCAT	0.612000													31	57					0	0	1	0	0	
TOP3A	7156	broad.mit.edu	37	17	18180995	18180995	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:18180995C>T	uc002gsx.1	-	18	3050	c.2821G>A	c.(2821-2823)GCT>ACT	p.A941T	TOP3A_uc010cpz.1_Missense_Mutation_p.A393T|TOP3A_uc010vxr.1_Missense_Mutation_p.A471T|TOP3A_uc002gsw.1_Missense_Mutation_p.A393T|TOP3A_uc010vxs.1_Missense_Mutation_p.A839T	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	941					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						TCACCTGGAGCGGTGTTCTCA	0.572000													35	68					0	0	1	0	0	
MAPK7	5598	broad.mit.edu	37	17	19284209	19284209	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:19284209G>A	uc002gvn.2	+	4	1073	c.687G>A	c.(685-687)GCG>GCA	p.A229A	B9D1_uc010cqm.1_5'Flank|B9D1_uc002gvl.3_5'Flank|MAPK7_uc002gvo.2_Silent_p.A90A|MAPK7_uc002gvq.2_Silent_p.A229A|MAPK7_uc002gvp.2_Silent_p.A229A	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	229	Necessary for oligomerization (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					GGTACCGTGCGCCCGAGCTCA	0.567000													16	19					0	0	1	0	0	
RNF112	7732	broad.mit.edu	37	17	19315988	19315988	+	Silent	SNP	G	A	A	rs149061657	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:19315988G>A	uc010vyw.1	+	3	472	c.273G>A	c.(271-273)CCG>CCA	p.P91P	RNF112_uc010vyu.1_Silent_p.P91P|RNF112_uc010vyv.1_Silent_p.P91P|RNF112_uc010vyx.1_Silent_p.P43P	NM_007148	NP_009079	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	91							GTP binding|GTPase activity|zinc ion binding			ovary(2)	2						GCTGTGAGCCGCCCTGCTGTC	0.657000													14	20					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	17	19349553	19349553	+	RNA	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:19349553G>A	uc002gvw.2	-	1		c.626C>T								Homo sapiens mRNA for ribosomal protein S2, partial cds.																		GTGCGGAGACGATGCCAGTGC	0.617000													4	2					0	0	1	0	0	
MAP2K3	5606	broad.mit.edu	37	17	21208385	21208385	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:21208385T>C	uc002gys.2	+	9	984	c.719T>C	c.(718-720)CTG>CCG	p.L240P	MAP2K3_uc002gyt.2_Missense_Mutation_p.L211P|MAP2K3_uc002gyu.2_Missense_Mutation_p.L211P	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	240	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		AACCCAGAGCTGAACCAGAAG	0.627000													18	126					0	0	1	0	0	
WSB1	26118	broad.mit.edu	37	17	25637145	25637145	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:25637145C>T	uc002gzd.1	+	7	1259	c.943C>T	c.(943-945)CGA>TGA	p.R315*	WSB1_uc002gze.1_Nonsense_Mutation_p.R169*|WSB1_uc002gzf.1_RNA	NM_015626	NP_056441	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box-containing 1 isoform 1	315	WD 6.				intracellular signal transduction	intracellular	protein binding				0	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CCGGTGGGTACGATCTGTATC	0.418000													36	52					0	0	1	0	0	
RAB34	83871	broad.mit.edu	37	17	27042713	27042713	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27042713C>T	uc002hce.2	-	5	949	c.325G>A	c.(325-327)GCT>ACT	p.A109T	RAB34_uc002hcg.2_Missense_Mutation_p.A109T|RAB34_uc002hcf.2_Missense_Mutation_p.A110T|RAB34_uc010was.1_Missense_Mutation_p.A166T|RAB34_uc010wat.1_Missense_Mutation_p.A166T|RAB34_uc002hch.2_Missense_Mutation_p.A109T|RAB34_uc010wau.1_Missense_Mutation_p.A87T|RAB34_uc010wav.1_Missense_Mutation_p.A167T	NM_031934	NP_114140	Q9BZG1	RAB34_HUMAN	Ras-related protein RAB34 isoform 1	109	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	Golgi apparatus	GTP binding				0	Lung NSC(42;0.00431)					TCCTGCCCAGCGGTATCCCAA	0.547000													26	75					0	0	1	0	0	
FLOT2	2319	broad.mit.edu	37	17	27215973	27215973	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27215973C>T	uc002hdc.2	-	2	244	c.121G>A	c.(121-123)GAC>AAC	p.D41N		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	41					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			CTCTGAGTGTCGGAGATACAC	0.592000													11	20					0	0	1	0	0	
PHF12	57649	broad.mit.edu	37	17	27248714	27248714	+	Silent	SNP	C	T	T	rs149472520	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27248714C>T	uc002hdg.1	-	5	1358	c.828G>A	c.(826-828)ACG>ACA	p.T276T	PHF12_uc010wbb.1_Silent_p.T258T|PHF12_uc002hdi.1_Silent_p.T272T|PHF12_uc002hdj.1_Silent_p.T276T|PHF12_uc010crw.1_Translation_Start_Site|PHF12_uc002hdh.1_Silent_p.T59T	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	276	PHD-type 2; atypical.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			ACCTGTTACACGTGAAGCAGA	0.398000													38	57					0	0	1	0	0	
SEZ6	124925	broad.mit.edu	37	17	27285070	27285070	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27285070C>T	uc002hdp.2	-	11	2391	c.2197G>A	c.(2197-2199)GTG>ATG	p.V733M	SEZ6_uc010crx.1_5'Flank|SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.V733M|SEZ6_uc002hdq.1_Missense_Mutation_p.V608M	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	733	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			TAAGTGACCACGGTGCCGTGC	0.607000													25	48					0	0	1	0	0	
SEZ6	124925	broad.mit.edu	37	17	27308688	27308688	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27308688G>A	uc002hdp.2	-	2	619	c.425C>T	c.(424-426)CCG>CTG	p.P142L	SEZ6_uc002hdm.2_RNA|SEZ6_uc010cry.1_Missense_Mutation_p.P142L|SEZ6_uc002hdq.1_Missense_Mutation_p.P17L|SEZ6_uc010crz.1_Missense_Mutation_p.P142L	NM_178860	NP_849191	Q53EL9	SEZ6_HUMAN	seizure related 6 homolog isoform 1	142	Pro-rich.|Extracellular (Potential).					integral to membrane|plasma membrane				large_intestine(1)|central_nervous_system(1)	2	Lung NSC(42;0.0137)		Epithelial(11;4.73e-06)|all cancers(11;2.91e-05)|BRCA - Breast invasive adenocarcinoma(11;8.06e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.111)			CTCTGACTCCGGACTCCAGGG	0.647000													5	17					0	0	1	0	0	
MYO18A	399687	broad.mit.edu	37	17	27493048	27493048	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27493048C>T	uc002hdt.1	-	2	1069	c.911G>A	c.(910-912)CGG>CAG	p.R304Q	MYO18A_uc010csa.1_Missense_Mutation_p.R304Q|MYO18A_uc002hdu.1_Missense_Mutation_p.R304Q	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	304	PDZ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CACCTTGAGCCGCACGCTGTC	0.612000													58	77					0	0	1	0	0	
TAOK1	57551	broad.mit.edu	37	17	27869613	27869613	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27869613G>A	uc002hdz.1	+	20	2773	c.2579G>A	c.(2578-2580)CGC>CAC	p.R860H	TAOK1_uc010wbe.1_Missense_Mutation_p.R712H|TAOK1_uc010wbf.1_Missense_Mutation_p.R860H	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	860	Potential.			R -> C (in Ref. 1; AAG38502).	mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			CAGAATGAGCGCACAGAACGA	0.378000													45	65					0	0	1	0	0	
SSH2	85464	broad.mit.edu	37	17	27958582	27958582	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27958582G>A	uc002heo.1	-	15	3549	c.3549C>T	c.(3547-3549)AGC>AGT	p.S1183S	SSH2_uc010wbh.1_Silent_p.S1210S	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1183					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TTAGGTCTGCGCTACTTAGCT	0.507000													37	71					0	0	1	0	0	
SLC6A4	6532	broad.mit.edu	37	17	28525491	28525491	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:28525491G>A	uc002hey.3	-	15	2420	c.1876C>T	c.(1876-1878)CGC>TGC	p.R626C	SLC6A4_uc010csg.2_RNA	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	626	Required for serotonin uptake activity.|Cytoplasmic (Potential).				response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	GCATTCAAGCGGATGTCCCCA	0.438000													25	41					0	0	1	0	0	
LRRC37B	114659	broad.mit.edu	37	17	30348267	30348267	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:30348267G>A	uc002hgu.2	+	1	113	c.102G>A	c.(100-102)CCG>CCA	p.P34P	LRRC37B_uc010wbx.1_Intron|LRRC37B_uc010csu.2_Silent_p.P34P	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	34	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				TCAAGGACCCGCTCCAGCTGA	0.617000													18	97					0	0	1	0	0	
RHBDL3	162494	broad.mit.edu	37	17	30621430	30621430	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:30621430C>T	uc002hhe.1	+	5	651	c.637C>T	c.(637-639)CGC>TGC	p.R213C	RHBDL3_uc010csw.1_Missense_Mutation_p.R205C|RHBDL3_uc010csx.1_Missense_Mutation_p.R213C|RHBDL3_uc010csy.1_Missense_Mutation_p.R115C|RHBDL3_uc002hhf.1_Missense_Mutation_p.R115C	NM_138328	NP_612201	P58872	RHBL3_HUMAN	rhomboid protease 3	213					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)				ACAGGTTTGGCGCTACCTGAC	0.473000													5	64					0	0	1	0	0	
PSMD11	5717	broad.mit.edu	37	17	30804557	30804557	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:30804557G>A	uc010cta.1	+	9	908	c.868G>A	c.(868-870)GTG>ATG	p.V290M	PSMD11_uc010wbz.1_Missense_Mutation_p.V290M|PSMD11_uc002hhm.2_Missense_Mutation_p.V290M	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	290	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			ATTAAAATGCGTGGCTCAGGC	0.408000													4	74					0	0	1	0	0	
ZNF830	91603	broad.mit.edu	37	17	33289371	33289371	+	Missense_Mutation	SNP	G	T	T	rs138078734	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:33289371G>T	uc002hih.3	+	1	823	c.786G>T	c.(784-786)AAG>AAT	p.K262N	CCT6B_uc002hig.2_5'Flank|CCT6B_uc010ctg.2_5'Flank|CCT6B_uc010wcc.1_5'Flank	NM_052857	NP_443089	Q96NB3	ZN830_HUMAN	coiled-coil domain containing 16	262					cell division|mitosis	cytoplasm|nucleus	metal ion binding			breast(1)	1		Ovarian(249;0.17)				GAGTACGAAAGGTTGATGCTC	0.463000													25	36					3.01185e-09	3.1308e-09	1	1	0	
AMAC1	146861	broad.mit.edu	37	17	33521221	33521221	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:33521221C>T	uc002hjd.2	-	1	192	c.106G>A	c.(106-108)GCC>ACC	p.A36T		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	36						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		CCACTGGTGGCATCAGAGGGC	0.667000													36	35					0	0	1	0	0	
SLFN12	55106	broad.mit.edu	37	17	33749996	33749996	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:33749996C>T	uc002hji.3	-	2	429	c.52G>A	c.(52-54)GTG>ATG	p.V18M	SLFN12_uc002hjj.3_Missense_Mutation_p.V18M|SLFN12_uc010cts.2_Missense_Mutation_p.V18M	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	18							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACTCTTCCCACATCTAGAACC	0.393000													61	102					0	0	1	0	0	
CASC3	22794	broad.mit.edu	37	17	38319960	38319960	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:38319960C>T	uc010cwt.1	+	7	1307	c.1012C>T	c.(1012-1014)CGG>TGG	p.R338W	CASC3_uc010cws.1_Missense_Mutation_p.R338W|CASC3_uc002hue.2_Missense_Mutation_p.R338W	NM_007359	NP_031385	O15234	CASC3_HUMAN	metastatic lymph node 51	338					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			ovary(1)	1						GCATGGTGGCCGGTCTGGTGA	0.557000													68	145					0	0	1	0	0	
KRT27	342574	broad.mit.edu	37	17	38938526	38938526	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:38938526C>A	uc002hvg.2	-	1	261	c.220G>T	c.(220-222)GGG>TGG	p.G74W		NM_181537	NP_853515	Q7Z3Y8	K1C27_HUMAN	keratin 27	74	Head.|Gly-rich.					cytoplasm|intermediate filament	structural molecule activity				0		Breast(137;0.000812)				TGCTCATTCCCTGTGAAGGCA	0.582000													35	48					2.42023e-17	2.57982e-17	1	1	0	
KRT39	390792	broad.mit.edu	37	17	39116561	39116561	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:39116561G>A	uc002hvo.1	-	6	1225	c.1189C>T	c.(1189-1191)CGC>TGC	p.R397C	KRT39_uc010wfm.1_Missense_Mutation_p.R130C	NM_213656	NP_998821	Q6A163	K1C39_HUMAN	type I hair keratin KA35	397	Coil 2.|Rod.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)|Ovarian(249;0.15)				AGAAGGCTGCGGTATGTGGTA	0.478000													12	115					0	0	1	0	0	
KRT31	3881	broad.mit.edu	37	17	39551220	39551220	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:39551220G>A	uc002hwn.2	-	6	1030	c.977C>T	c.(976-978)GCG>GTG	p.A326V	KRT31_uc010cxn.2_Missense_Mutation_p.A326V	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	326	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GCGGATCTCCGCCAGCTGGGA	0.617000													34	56					0	0	1	0	0	
KRT17	3872	broad.mit.edu	37	17	39777997	39777997	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:39777997C>T	uc002hxh.2	-	4	803	c.682G>A	c.(682-684)GCC>ACC	p.A228T	JUP_uc010wfs.1_Intron	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	228	Coil 1B.|Rod.				epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				CCTCGCAGGGCGTTCATCTCC	0.597000									Steatocystoma_Multiplex				15	31					0	0	1	0	0	
STAT5A	6776	broad.mit.edu	37	17	40453375	40453375	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:40453375G>A	uc002hzj.1	+	10	1714	c.1072G>A	c.(1072-1074)GGG>AGG	p.G358R	STAT5A_uc010cya.1_Missense_Mutation_p.G358R|STAT5A_uc010cyb.1_Missense_Mutation_p.G358R|STAT5A_uc010cyc.1_Missense_Mutation_p.G328R	NM_003152	NP_003143	P42229	STA5A_HUMAN	signal transducer and activator of transcription	358					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|oxaloacetate metabolic process|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(22;1.56e-06)|all_epithelial(22;3.17e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		GCTGGTGGGCGGGAAGCTGAA	0.557000													40	76					0	0	1	0	0	
HSD17B1	3292	broad.mit.edu	37	17	40705488	40705488	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:40705488G>A	uc002hzw.2	+	3	1265	c.297G>A	c.(295-297)CCG>CCA	p.P99P	HSD17B1_uc002hzx.2_Silent_p.P99P|HSD17B1_uc010wgm.1_RNA|uc002hzy.2_Silent_p.S31S|HSD17B1_uc010cyi.2_Silent_p.P130P	NM_000413	NP_000404	P14061	DHB1_HUMAN	hydroxysteroid (17-beta) dehydrogenase 1	99					estrogen biosynthetic process	cytosol	binding|estradiol 17-beta-dehydrogenase activity				0		all_cancers(22;5.59e-08)|all_epithelial(22;7e-07)|Ovarian(249;0.0261)		BRCA - Breast invasive adenocarcinoma(366;0.129)	NADH(DB00157)	TGCTGGGGCCGCTGGAGGCGC	0.672000													24	29					0	0	1	0	0	
TUBG1	7283	broad.mit.edu	37	17	40765935	40765935	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:40765935C>T	uc002ian.2	+	8	1160	c.762C>T	c.(760-762)ATC>ATT	p.I254I		NM_001070	NP_001061	P23258	TBG1_HUMAN	tubulin, gamma 1	254					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		ATGACCTCATCGGCCTCATCG	0.592000													38	128					0	0	1	0	0	
TUBG2	27175	broad.mit.edu	37	17	40814996	40814996	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:40814996C>T	uc010wgr.1	+	5	661	c.405C>T	c.(403-405)TTC>TTT	p.F135F	TUBG2_uc002iaq.2_5'UTR|TUBG2_uc002iar.2_Intron|TUBG2_uc002ias.2_5'UTR|TUBG2_uc002iap.2_Intron	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	135					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		CACAGGGCTTCGTGCTGTGTC	0.348000													60	69					0	0	1	0	0	
CNTNAP1	8506	broad.mit.edu	37	17	40844682	40844682	+	Missense_Mutation	SNP	G	A	A	rs144243880		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:40844682G>A	uc002iay.2	+	17	2912	c.2696G>A	c.(2695-2697)CGG>CAG	p.R899Q	CNTNAP1_uc010wgs.1_RNA	NM_003632	NP_003623	P78357	CNTP1_HUMAN	contactin associated protein 1 precursor	899	Laminin G-like 3.|Extracellular (Potential).				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(3)|breast(3)|upper_aerodigestive_tract(1)|lung(1)	8		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		TGGGTTCTGCGGCCTATGCCA	0.577000													30	58					0	0	1	0	0	
AOC3	8639	broad.mit.edu	37	17	41004138	41004138	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:41004138A>G	uc002ibv.2	+	1	938	c.778A>G	c.(778-780)ACT>GCT	p.T260A		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	260	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	TGCCCGCTGGACTATCCAGAA	0.597000													19	37					0	0	1	0	0	
AOC3	8639	broad.mit.edu	37	17	41006671	41006671	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:41006671T>A	uc002ibv.2	+	2	1967	c.1807T>A	c.(1807-1809)TAC>AAC	p.Y603N		NM_003734	NP_003725	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3 precursor	603	Extracellular (Potential).				amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			central_nervous_system(2)|ovary(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CCCCCGGGGCTACCGCATCCA	0.647000													25	31					0	0	1	0	0	
AARSD1	80755	broad.mit.edu	37	17	41108509	41108509	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:41108509G>A	uc002icc.2	-	5	461	c.458C>T	c.(457-459)GCC>GTC	p.A153V	AARSD1_uc002icd.2_Missense_Mutation_p.A266V|AARSD1_uc002ice.2_Missense_Mutation_p.A236V|AARSD1_uc002icf.2_Missense_Mutation_p.A327V|AARSD1_uc010whg.1_Missense_Mutation_p.A327V|AARSD1_uc010cyu.1_Missense_Mutation_p.A153V	NM_025267	NP_079543	Q9BTE6	AASD1_HUMAN	alanyl-tRNA synthetase domain containing 1	153					alanyl-tRNA aminoacylation	cytoplasm	alanine-tRNA ligase activity|ATP binding|metal ion binding|nucleic acid binding				0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CTGCTCAATGGCAGCTACTTG	0.488000													17	37					0	0	1	0	0	
RUNDC1	146923	broad.mit.edu	37	17	41141481	41141481	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:41141481C>T	uc002ici.1	+	3	793	c.781C>T	c.(781-783)CGA>TGA	p.R261*	RUNDC1_uc010whi.1_Nonsense_Mutation_p.R31*	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	261											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		CAACCCAGCCCGAGTCAAAGA	0.483000													29	39					0	0	1	0	0	
NBR1	4077	broad.mit.edu	37	17	41343459	41343459	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:41343459C>T	uc010czd.2	+	10	1074	c.934C>T	c.(934-936)CGT>TGT	p.R312C	NBR1_uc010diz.2_Missense_Mutation_p.R312C|NBR1_uc010whu.1_Missense_Mutation_p.R312C|NBR1_uc010whv.1_Missense_Mutation_p.R312C|NBR1_uc010whw.1_Missense_Mutation_p.R291C|NBR1_uc010whx.1_Missense_Mutation_p.R121C	NM_031862	NP_114068	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	312					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			skin(1)	1		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GAAGAAACAACGTAAAGCAGA	0.403000													6	13					0	0	1	0	0	
UBTF	7343	broad.mit.edu	37	17	42288502	42288502	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:42288502G>C	uc002igb.2	-	11	1175	c.1108C>G	c.(1108-1110)CAG>GAG	p.Q370E	UBTF_uc002igc.2_Missense_Mutation_p.Q333E|UBTF_uc010czs.2_Missense_Mutation_p.Q370E|UBTF_uc002igd.2_Missense_Mutation_p.Q333E|UBTF_uc010czt.2_Missense_Mutation_p.Q370E|UBTF_uc002ige.2_Missense_Mutation_p.Q333E	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	370					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		ACCCGCTGCTGCTCCTCCTCA	0.637000													49	66					0	0	1	0	0	
SLC4A1	6521	broad.mit.edu	37	17	42330695	42330695	+	Missense_Mutation	SNP	C	T	T	rs121912748		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:42330695C>T	uc002igf.3	-	17	2251	c.2102G>A	c.(2101-2103)GGC>GAC	p.G701D		NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	701	Membrane (anion exchange).|Helical; (Potential).		G -> D (in AR-dRTA).		bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CAGGTGGAAGCCGGAGCCCTT	0.637000													23	47					0	0	1	0	0	
FZD2	2535	broad.mit.edu	37	17	42636425	42636425	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:42636425C>T	uc002igx.1	+	1	1501	c.1369C>T	c.(1369-1371)CGG>TGG	p.R457W		NM_001466	NP_001457	Q14332	FZD2_HUMAN	frizzled 2 precursor	457	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		AAAGCTGGAGCGGCTCATGGT	0.617000													42	47					0	0	1	0	0	
PLCD3	113026	broad.mit.edu	37	17	43192542	43192542	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:43192542T>G	uc002iib.2	-	11	1745	c.1631A>C	c.(1630-1632)CAC>CCC	p.H544P		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	phospholipase C delta 3	544	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|lung(1)	3					Phosphatidylserine(DB00144)	GGGGGCAGGGTGCAGGGTCGC	0.672000													3	4					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	17	45127136	45127136	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:45127136C>T	uc010wkj.1	+	2	688	c.334C>T	c.(334-336)CTG>TTG	p.L112L	uc010wkl.1_RNA					SubName: Full=Putative uncharacterized protein LRRC37A3;																		AGTCTCTGTGCTGACACCCTT	0.547000													5	48					0	0	1	0	0	
TBKBP1	9755	broad.mit.edu	37	17	45786619	45786619	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:45786619G>A	uc002ilu.2	+	8	2369	c.1520G>A	c.(1519-1521)CGC>CAC	p.R507H		NM_014726	NP_055541	A7MCY6	TBKB1_HUMAN	TBK1 binding protein 1	507					innate immune response						0						AGCCCGCGGCGCGCCTTCGAG	0.751000													3	1					0	0	1	0	0	
HOXB5	3215	broad.mit.edu	37	17	46670643	46670643	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:46670643G>A	uc002inr.2	-	1	461	c.402C>T	c.(400-402)GAC>GAT	p.D134D		NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5	134						nucleus	sequence-specific DNA binding				0						CGCTGGCCTCGTCTATTTCGG	0.682000													20	25					0	0	1	0	0	
HOXB6	3216	broad.mit.edu	37	17	46674002	46674002	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:46674002G>A	uc002ins.1	-	4	773	c.448C>T	c.(448-450)CGC>TGC	p.R150C	HOXB5_uc002inr.2_5'Flank|HOXB6_uc010dbh.1_Missense_Mutation_p.R150C|HOXB6_uc002int.1_3'UTR	NM_018952	NP_061825	P17509	HXB6_HUMAN	homeobox B6	150	Homeobox.			GR -> A (in Ref. 7; AAA36004).	anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TATGTCTGGCGGCCTCGCCGG	0.657000													36	58					0	0	1	0	0	
COL1A1	1277	broad.mit.edu	37	17	48267382	48267382	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:48267382C>T	uc002iqm.2	-	36	2665	c.2539G>A	c.(2539-2541)GCT>ACT	p.A847T		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	847	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	GGGGGTCCAGCGGGTCCGGCA	0.672000			T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta						48	44					0	0	1	0	0	
XYLT2	64132	broad.mit.edu	37	17	48434499	48434499	+	Silent	SNP	G	A	A	rs145129008		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:48434499G>A	uc002iqo.2	+	9	1936	c.1827G>A	c.(1825-1827)GCG>GCA	p.A609A	XYLT2_uc010dbo.2_Intron	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	609	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					TGACGCAGGCGGTGCAGCCCT	0.647000													20	21					0	0	1	0	0	
EPN3	55040	broad.mit.edu	37	17	48618282	48618282	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:48618282T>G	uc002ira.3	+	7	1543	c.1108T>G	c.(1108-1110)TCT>GCT	p.S370A	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Missense_Mutation_p.S398A|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.S343A	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	370	5 X 3 AA repeats of [DE]-P-W.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			GCTCTCCTCCTCTGAGCCCTG	0.677000													14	25					0	0	1	0	0	
KIF2B	84643	broad.mit.edu	37	17	51901717	51901717	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:51901717C>T	uc002iua.2	+	1	1479	c.1323C>T	c.(1321-1323)GGC>GGT	p.G441G	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	441	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TAATGCATGGCAAGTTTTCCC	0.507000													23	38					0	0	1	0	0	
TOM1L1	10040	broad.mit.edu	37	17	53014489	53014489	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:53014489C>T	uc002iud.2	+	10	1110	c.935C>T	c.(934-936)GCC>GTC	p.A312V	TOM1L1_uc002iuc.2_Missense_Mutation_p.A312V|TOM1L1_uc010dca.1_Missense_Mutation_p.A312V|TOM1L1_uc010wnb.1_Missense_Mutation_p.A305V|TOM1L1_uc010wnc.1_Missense_Mutation_p.A235V|TOM1L1_uc010dbz.2_Missense_Mutation_p.A235V|TOM1L1_uc010wnd.1_Missense_Mutation_p.A200V|TOM1L1_uc010dcb.1_RNA	NM_005486	NP_005477	O75674	TM1L1_HUMAN	target of myb1-like 1	312					intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			ovary(1)	1						GAGCCTTCTGCCCCATCTCAA	0.453000													36	50					0	0	1	0	0	
VEZF1	7716	broad.mit.edu	37	17	56056610	56056610	+	Silent	SNP	C	T	T	rs145983359	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:56056610C>T	uc002ivf.1	-	5	1184	c.1041G>A	c.(1039-1041)CAG>CAA	p.Q347Q	VEZF1_uc010dcn.1_Silent_p.Q197Q	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	347	Poly-Gln.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						gttgttgctgctgctgctgct	0.303000													31	106					0	0	1	0	0	
VEZF1	7716	broad.mit.edu	37	17	56060687	56060687	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:56060687G>A	uc002ivf.1	-	2	244	c.101C>T	c.(100-102)GCC>GTC	p.A34V	VEZF1_uc010dcn.1_5'UTR	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	34					cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						GGGCTCCACGGCAGAGCTCAG	0.478000													49	81					0	0	1	0	0	
OR4D1	26689	broad.mit.edu	37	17	56233200	56233200	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:56233200C>T	uc010wno.1	+	1	686	c.686C>T	c.(685-687)TCG>TTG	p.S229L	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AGGTCCCACTCGGGAAAGGCA	0.507000													23	36					0	0	1	0	0	
MKS1	54903	broad.mit.edu	37	17	56291642	56291642	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:56291642C>T	uc002ivr.1	-	6	697	c.622G>A	c.(622-624)GCA>ACA	p.A208T	MKS1_uc010wnq.1_Missense_Mutation_p.A5T|MKS1_uc002ivs.1_Missense_Mutation_p.A208T	NM_017777	NP_060247	Q9NXB0	MKS1_HUMAN	Meckel syndrome type 1 protein isoform 1	208					cilium assembly	centrosome|cilium|microtubule basal body	protein binding			ovary(1)	1						CCCAGGTCTGCCATGATGTGC	0.522000													19	45					0	0	1	0	0	
RAD51C	5889	broad.mit.edu	37	17	56811500	56811500	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:56811500G>A	uc002iwu.2	+	9	1090	c.1048G>A	c.(1048-1050)GTT>ATT	p.V350I	RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	350					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TAGAGATACTGTTGTTACTTC	0.348000								Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				12	18					0	0	1	0	0	
TLK2	11011	broad.mit.edu	37	17	60598172	60598172	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:60598172C>T	uc010ddp.2	+	3	388	c.120C>T	c.(118-120)TGC>TGT	p.C40C	TLK2_uc002izx.3_5'UTR|TLK2_uc002izz.3_Silent_p.C40C|TLK2_uc002jaa.3_Silent_p.C40C|TLK2_uc010wpd.1_Silent_p.C40C	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	40					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						AGAGCTTGTGCAGCGTCGGAT	0.323000													5	112					0	0	1	0	0	
TANC2	26115	broad.mit.edu	37	17	61498206	61498206	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:61498206C>T	uc002jal.3	+	25	4886	c.4863C>T	c.(4861-4863)GCC>GCT	p.A1621A	TANC2_uc010wpe.1_3'UTR|TANC2_uc002jao.3_Silent_p.A732A	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1621							binding			ovary(2)	2						CCAGCCCAGCCGTCCATTCAA	0.572000													36	75					0	0	1	0	0	
CCDC47	57003	broad.mit.edu	37	17	61824306	61824306	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:61824306G>A	uc002jbs.3	-	13	1723	c.1387C>T	c.(1387-1389)CGT>TGT	p.R463C	CCDC47_uc010ddx.2_Missense_Mutation_p.R463C	NM_020198	NP_064583	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47 precursor	463	Potential.					integral to membrane	protein binding				0						TTTTGCTCACGCCTCAATGCA	0.383000													15	12					0	0	1	0	0	
FTSJ3	117246	broad.mit.edu	37	17	61898289	61898289	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:61898289C>T	uc002jbz.2	-	17	2060	c.1982G>A	c.(1981-1983)CGG>CAG	p.R661Q	FTSJ3_uc002jca.2_Missense_Mutation_p.R661Q	NM_017647	NP_060117	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3	661					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			ovary(1)	1						GTCCAGTATCCGATGTTTCGC	0.488000													34	54					0	0	1	0	0	
SMARCD2	6603	broad.mit.edu	37	17	61912912	61912912	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:61912912G>A	uc010deb.1	-	5	900	c.583C>T	c.(583-585)CGG>TGG	p.R195W	SMARCD2_uc010wpt.1_Missense_Mutation_p.R147W|SMARCD2_uc010dea.1_Missense_Mutation_p.R120W|SMARCD2_uc010dec.1_Missense_Mutation_p.R174W	NM_001098426	NP_001091896	Q92925	SMRD2_HUMAN	SWI/SNF-related matrix-associated	195					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity				0						ATGTAGATCCGAAGCTTTCGC	0.522000													26	47					0	0	1	0	0	
CSH1	1442	broad.mit.edu	37	17	61972557	61972557	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:61972557C>T	uc002jcs.1	-	5	595	c.479G>A	c.(478-480)CGG>CAG	p.R160Q	CSH2_uc002jck.2_Intron|CSH1_uc002jcp.1_Silent_p.P150P|CSH1_uc002jcq.1_Missense_Mutation_p.R121Q|CSH1_uc002jcr.1_3'UTR|CSH1_uc002jct.1_Missense_Mutation_p.R126Q|CSH1_uc002jcu.1_Silent_p.P244P|CSH1_uc002jcv.1_Missense_Mutation_p.R65Q|CSH1_uc002jcw.2_Silent_p.P159P|CSH1_uc002jcy.2_3'UTR	NM_001317	NP_001308	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 1 isoform 1	160					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			skin(1)	1						CTGCCCAGTCCGGCGGCTGCC	0.547000									Russell-Silver_syndrome				61	96					0	0	1	0	0	
KPNA2	3838	broad.mit.edu	37	17	66040473	66040473	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:66040473G>A	uc002jgk.2	+	9	1333	c.1201G>A	c.(1201-1203)GTG>ATG	p.V401M	KPNA2_uc002jgl.2_Missense_Mutation_p.V401M	NM_002266	NP_002257	P52292	IMA2_HUMAN	karyopherin alpha 2	401	NLS binding site (minor) (By similarity).|ARM 8.				DNA metabolic process|G2 phase of mitotic cell cycle|interspecies interaction between organisms|M phase specific microtubule process|NLS-bearing substrate import into nucleus|regulation of DNA recombination	cytoplasm|nuclear pore|nucleoplasm	histone deacetylase binding|nuclear localization sequence binding|protein transporter activity			central_nervous_system(2)	2	all_cancers(12;1.18e-09)		BRCA - Breast invasive adenocarcinoma(8;1.03e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTGTGGGCCGTGACCAACTA	0.388000													17	211					0	0	1	0	0	
FAM20A	54757	broad.mit.edu	37	17	66533689	66533689	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:66533689G>A	uc002jho.2	-	11	1843	c.1555C>T	c.(1555-1557)CAG>TAG	p.Q519*	FAM20A_uc010wqp.1_Nonsense_Mutation_p.Q381*|PRKAR1A_uc002jhm.2_Intron|FAM20A_uc002jhn.2_Nonsense_Mutation_p.Q230*	NM_017565	NP_060035	Q96MK3	FA20A_HUMAN	family with sequence similarity 20, member A	519						extracellular region					0	Breast(10;1.64e-13)					ATGACACTCTGCTGTCCATGG	0.567000													11	19					0	0	1	0	0	
KCNJ16	3773	broad.mit.edu	37	17	68128923	68128923	+	Missense_Mutation	SNP	C	T	T	rs145663054	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:68128923C>T	uc002jin.2	+	5	1181	c.695C>T	c.(694-696)ACG>ATG	p.T232M	KCNJ16_uc002jio.2_Missense_Mutation_p.T232M|KCNJ16_uc002jip.2_Missense_Mutation_p.T232M|KCNJ16_uc002jiq.2_Missense_Mutation_p.T264M	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	232	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					GGGAGGATGACGATGGCATTT	0.478000													30	58					0	0	1	0	0	
KCNJ16	3773	broad.mit.edu	37	17	68129127	68129127	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:68129127T>A	uc002jin.2	+	5	1385	c.899T>A	c.(898-900)GTT>GAT	p.V300D	KCNJ16_uc002jio.2_Missense_Mutation_p.V300D|KCNJ16_uc002jip.2_Missense_Mutation_p.V300D|KCNJ16_uc002jiq.2_Missense_Mutation_p.V332D	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	300	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					AGCTCCTATGTTCCCCGAGAA	0.408000													37	66					0	0	1	0	0	
RAB37	326624	broad.mit.edu	37	17	72739292	72739292	+	Missense_Mutation	SNP	C	T	T	rs148960641		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:72739292C>T	uc002jlk.2	+	4	327	c.271C>T	c.(271-273)CGG>TGG	p.R91W	RAB37_uc002jlc.2_Missense_Mutation_p.R84W|RAB37_uc010dfu.2_Missense_Mutation_p.R84W|RAB37_uc002jld.2_Missense_Mutation_p.R84W|RAB37_uc010wrb.1_Missense_Mutation_p.R59W|RAB37_uc010wrc.1_Missense_Mutation_p.R96W|RAB37_uc010wrd.1_Missense_Mutation_p.R59W|RAB37_uc010wre.1_Missense_Mutation_p.R54W|RAB37_uc002jll.3_RNA	NM_001006638	NP_001006639	Q96AX2	RAB37_HUMAN	RAB37, member RAS oncogene family isoform 2	91					protein transport|small GTPase mediated signal transduction	ER-Golgi intermediate compartment	GTP binding			ovary(1)	1						TGGGCAGGAACGGTTCCGAAG	0.597000													32	68					0	0	1	0	0	
GGA3	23163	broad.mit.edu	37	17	73239146	73239146	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:73239146T>C	uc002jni.1	-	6	535	c.526A>G	c.(526-528)AAG>GAG	p.K176E	GGA3_uc002jnj.1_Missense_Mutation_p.K143E|GGA3_uc010wrw.1_Missense_Mutation_p.K54E|GGA3_uc002jnk.1_Missense_Mutation_p.K104E|GGA3_uc010wrx.1_Missense_Mutation_p.K54E|GGA3_uc010wry.1_Missense_Mutation_p.K104E|GGA3_uc010wrz.1_Intron	NM_138619	NP_619525	Q9NZ52	GGA3_HUMAN	ADP-ribosylation factor binding protein 3	176	GAT.|Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			ovary(1)|breast(1)	2			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			TCCTTTACCTTGGACTTCTCC	0.552000													43	81					0	0	1	0	0	
GRB2	2885	broad.mit.edu	37	17	73316454	73316454	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:73316454C>T	uc002jnx.3	-	6	1006	c.649G>A	c.(649-651)GTC>ATC	p.V217I	GRB2_uc002jny.3_Missense_Mutation_p.V176I	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	217					axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	GACTCTTAGACGTTCCGGTTC	0.473000													85	131					0	0	1	0	0	
KIAA0195	9772	broad.mit.edu	37	17	73486331	73486331	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:73486331C>A	uc002jnz.3	+	10	1246	c.971C>A	c.(970-972)CCC>CAC	p.P324H	KIAA0195_uc010wsa.1_Missense_Mutation_p.P334H|KIAA0195_uc010wsb.1_5'UTR	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	324	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGCGTCCTGCCCATCCTCCCC	0.672000													39	76					2.77807e-22	2.97982e-22	1	1	0	
GALR2	8811	broad.mit.edu	37	17	74071131	74071131	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:74071131C>T	uc002jqm.1	+	1	248	c.167C>T	c.(166-168)GCG>GTG	p.A56V	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	56	Cytoplasmic (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						GGCGGCCAGGCGGTCAGCACT	0.657000													25	24					0	0	1	0	0	
TIMP2	7077	broad.mit.edu	37	17	76851906	76851906	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:76851906G>A	uc002jwf.2	-	5	808	c.506C>T	c.(505-507)CCG>CTG	p.P169L	TIMP2_uc002jwe.2_Missense_Mutation_p.P92L|TIMP2_uc010wty.1_Missense_Mutation_p.P92L	NM_003255	NP_003246	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2 precursor	169							metal ion binding|metalloendopeptidase inhibitor activity			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			GCACTCGTCCGGGGAGGAGAT	0.637000													29	50					0	0	1	0	0	
ENPP7	339221	broad.mit.edu	37	17	77707394	77707394	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:77707394C>T	uc002jxa.2	+	2	362	c.342C>T	c.(340-342)GGC>GGT	p.G114G		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	114					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCACGCTGGGCATCCAGAGGT	0.592000													17	22					0	0	1	0	0	
ENPP7	339221	broad.mit.edu	37	17	77709291	77709291	+	Silent	SNP	C	T	T	rs149462169	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:77709291C>T	uc002jxa.2	+	3	869	c.849C>T	c.(847-849)AAC>AAT	p.N283N		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	283					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			ACGGACCAAACGGGATGCTGC	0.587000													16	45					0	0	1	0	0	
GAA	2548	broad.mit.edu	37	17	78090851	78090851	+	Silent	SNP	C	T	T	rs150431943	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:78090851C>T	uc002jxo.2	+	17	2456	c.2274C>T	c.(2272-2274)GCC>GCT	p.A758A	GAA_uc002jxp.2_Silent_p.A758A|GAA_uc002jxq.2_Silent_p.A758A	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	758					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	TGCTCCAGGCCGGGAAGGCCG	0.647000													21	25					0	0	1	0	0	
SLC26A11	284129	broad.mit.edu	37	17	78195370	78195370	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:78195370C>T	uc002jyb.1	+	3	280	c.11C>T	c.(10-12)TCG>TTG	p.S4L	SGSH_uc002jxz.3_5'Flank|SGSH_uc002jya.3_5'Flank|SGSH_uc002jxy.2_5'Flank|SGSH_uc010wue.1_5'Flank|SLC26A11_uc002jyc.1_Missense_Mutation_p.S4L|SLC26A11_uc002jyd.1_Missense_Mutation_p.S4L|SLC26A11_uc010dhv.1_Missense_Mutation_p.S4L	NM_173626	NP_775897	Q86WA9	S2611_HUMAN	solute carrier family 26, member 11	4	Extracellular (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity				0	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			ATGCCTTCTTCGGTGACGGCG	0.687000													4	13					0	0	1	0	0	
AATK	9625	broad.mit.edu	37	17	79094123	79094123	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:79094123G>A	uc010dia.2	-	11	3693	c.3613C>T	c.(3613-3615)CGC>TGC	p.R1205C	AATK_uc010dhz.2_RNA	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	1205						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CGCAGGTTGCGCGCGCTCTGG	0.657000													13	21					0	0	1	0	0	
AATK	9625	broad.mit.edu	37	17	79095729	79095729	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:79095729C>T	uc010dia.2	-	11	2087	c.2007G>A	c.(2005-2007)GCG>GCA	p.A669A	AATK_uc010dhz.2_RNA	NM_001080395	NP_001073864	Q6ZMQ8	LMTK1_HUMAN	apoptosis-associated tyrosine kinase	669						integral to membrane|mitochondrion|perinuclear region of cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(4)|ovary(2)|lung(2)|upper_aerodigestive_tract(1)	9	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			CGGCCCTCCGCGCTCCCACCT	0.706000													12	18					0	0	1	0	0	
SLC38A10	124565	broad.mit.edu	37	17	79220706	79220706	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:79220706C>T	uc002jzz.1	-	15	2596	c.2221G>A	c.(2221-2223)GAG>AAG	p.E741K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E659K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	741					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			TTATCCTCCTCGTCCTCCTGC	0.652000													26	36					0	0	1	0	0	
SLC38A10	124565	broad.mit.edu	37	17	79234119	79234119	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:79234119C>T	uc002jzz.1	-	11	1582	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	SLC38A10_uc002jzy.1_Missense_Mutation_p.E321K|SLC38A10_uc002kab.2_Missense_Mutation_p.E403K	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	403					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			GCCAAGTCCTCGGGGACCTCC	0.662000													5	15					0	0	1	0	0	
DCXR	51181	broad.mit.edu	37	17	79994510	79994510	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:79994510T>C	uc002kdg.2	-	5	373	c.358A>G	c.(358-360)AGG>GGG	p.R120G		NM_016286	NP_057370	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	120					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity				0	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			ATTAAGCCCCTGGCCACAATC	0.612000													30	35					0	0	1	0	0	
DUS1L	64118	broad.mit.edu	37	17	80018606	80018606	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:80018606G>A	uc002kdq.2	-	9	1412	c.993C>T	c.(991-993)CAC>CAT	p.H331H	DUS1L_uc002kdp.2_Silent_p.H200H|DUS1L_uc002kdr.2_Silent_p.H331H|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	331					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGCAGATCCAGTGGAAGGGCA	0.677000													16	12					0	0	1	0	0	
FASN	2194	broad.mit.edu	37	17	80041487	80041487	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:80041487C>T	uc002kdu.2	-	31	5364	c.5247G>A	c.(5245-5247)GCG>GCA	p.A1749A	FASN_uc002kdv.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	1749	Enoyl reductase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GCTTCTCTTCCGCCAAGGAGT	0.612000													6	10					0	0	1	0	0	
FASN	2194	broad.mit.edu	37	17	80049207	80049207	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:80049207G>A	uc002kdu.2	-	9	1500	c.1383C>T	c.(1381-1383)CCC>CCT	p.P461P	FASN_uc002kdw.1_5'Flank	NM_004104	NP_004095	P49327	FAS_HUMAN	fatty acid synthase	461	Acyl and malonyl transferases (By similarity).			AVPA -> LSPT (in Ref. 2; AAA73576).	energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	TGGCGGTGGCGGGGACAGCCG	0.697000													9	10					0	0	1	0	0	
ADCYAP1	116	broad.mit.edu	37	18	909505	909505	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:909505G>C	uc010dkg.2	+	5	519	c.400G>C	c.(400-402)GAC>CAC	p.D134H	ADCYAP1_uc010dkh.2_Missense_Mutation_p.D134H	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	134					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						GCGCCACTCGGACGGGATCTT	0.627000													43	93					0	0	1	0	0	
TMEM200C	645369	broad.mit.edu	37	18	5891840	5891840	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:5891840A>G	uc002kmx.1	-	1	264	c.223T>C	c.(223-225)TGG>CGG	p.W75R		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	75						integral to membrane					0						GCCTTGGGCCAGTAGCCCACC	0.662000													10	25					0	0	1	0	0	
LAMA1	284217	broad.mit.edu	37	18	6950849	6950849	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:6950849A>C	uc002knm.2	-	58	8423	c.8329T>G	c.(8329-8331)TTT>GTT	p.F2777V	LAMA1_uc002knk.2_Missense_Mutation_p.F107V|LAMA1_uc002knl.2_Missense_Mutation_p.F230V|LAMA1_uc010wzj.1_Missense_Mutation_p.F2253V	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2777	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCAAGGTCAAACATGAAGTGG	0.577000													20	46					0	0	1	0	0	
LAMA1	284217	broad.mit.edu	37	18	6958539	6958539	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:6958539G>A	uc002knm.2	-	55	7995	c.7901C>T	c.(7900-7902)ACG>ATG	p.T2634M	LAMA1_uc002knk.2_5'Flank|LAMA1_uc002knl.2_Missense_Mutation_p.T87M|LAMA1_uc010wzj.1_Missense_Mutation_p.T2110M	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2634	Laminin G-like 3.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGCAGTGACGTCCCCTCTCC	0.458000													30	28					0	0	1	0	0	
ANKRD12	23253	broad.mit.edu	37	18	9254358	9254358	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:9254358G>T	uc002knv.2	+	9	1350	c.1093G>T	c.(1093-1095)GAT>TAT	p.D365Y	ANKRD12_uc002knw.2_Missense_Mutation_p.D342Y|ANKRD12_uc002knx.2_Missense_Mutation_p.D342Y|ANKRD12_uc010dkx.1_Missense_Mutation_p.D72Y	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	365						nucleus				ovary(2)|central_nervous_system(1)	3						TGAGTTCAAAGATGATGATGA	0.348000													27	57					2.41591e-17	2.57655e-17	1	1	0	
TUBB6	84617	broad.mit.edu	37	18	12325616	12325616	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:12325616C>T	uc002kqw.2	+	4	873	c.828C>T	c.(826-828)CGC>CGT	p.R276R	TUBB6_uc002kqv.2_Silent_p.R204R|TUBB6_uc010dld.2_RNA|TUBB6_uc002kqx.2_Silent_p.R239R|TUBB6_uc002kqy.2_Intron	NM_032525	NP_115914	Q9BUF5	TBB6_HUMAN	tubulin, beta 6	276					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity				0				READ - Rectum adenocarcinoma(1;0.0649)		TCACCAGCCGCGGCAGCCAGC	0.682000													33	30					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	18	14179436	14179436	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:14179436C>A	uc010xag.1	+	1	341	c.43C>A	c.(43-45)CTG>ATG	p.L15M						RecName: Full=Putative ankyrin repeat domain-containing protein 20A5;																		CCAGACGGTCCTGGGCTCCAT	0.602000													5	13					0.000602214	0.000609638	1	1	0	
RIOK3	8780	broad.mit.edu	37	18	21057190	21057190	+	Silent	SNP	C	T	T	rs56187215		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:21057190C>T	uc002kui.3	+	11	1919	c.1302C>T	c.(1300-1302)CAC>CAT	p.H434H	RIOK3_uc010dls.2_Silent_p.H434H|RIOK3_uc010xas.1_Silent_p.H418H|RIOK3_uc010xat.1_Silent_p.H178H	NM_003831	NP_003822	O14730	RIOK3_HUMAN	sudD suppressor of bimD6 homolog	434	Protein kinase.				chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCCACCCTCACGGCCTGGAGT	0.413000													39	58					0	0	1	0	0	
ZNF521	25925	broad.mit.edu	37	18	22807137	22807137	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:22807137T>C	uc002kvk.2	-	4	992	c.745A>G	c.(745-747)AGT>GGT	p.S249G	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S249G|ZNF521_uc002kvl.2_Missense_Mutation_p.S29G	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	249	C2H2-type 6.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCACACTGACTGCACTTCTGA	0.547000			T	PAX5	ALL								30	50					0	0	1	0	0	
KCTD1	284252	broad.mit.edu	37	18	24039669	24039669	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:24039669T>C	uc002kvw.2	-	4	1090	c.530A>G	c.(529-531)AAC>AGC	p.N177S	KCTD1_uc010xbj.1_Missense_Mutation_p.N785S|KCTD1_uc010xbk.1_Missense_Mutation_p.N177S|KCTD1_uc002kvy.2_Missense_Mutation_p.N95S	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	177					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			ATTGACAGAGTTACACATCAC	0.502000													36	47					0	0	1	0	0	
FHOD3	80206	broad.mit.edu	37	18	34310626	34310626	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:34310626A>G	uc002kzt.1	+	16	2956	c.2859A>G	c.(2857-2859)GGA>GGG	p.G953G	FHOD3_uc002kzs.1_Silent_p.G970G|FHOD3_uc010dmz.1_Silent_p.G685G|FHOD3_uc010dnb.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	953	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CTGCAGATGGAAAAAGGCAAG	0.413000													26	49					0	0	1	0	0	
SYT4	6860	broad.mit.edu	37	18	40851770	40851770	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:40851770T>A	uc002law.2	-	3	1246	c.877A>T	c.(877-879)ATC>TTC	p.I293F	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Missense_Mutation_p.I275F|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	293	Phospholipid binding (Probable).|C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CAGAGAGAGATCAGTAACTCA	0.383000													42	57					0	0	1	0	0	
SETBP1	26040	broad.mit.edu	37	18	42281385	42281385	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:42281385C>T	uc010dni.2	+	2	370	c.74C>T	c.(73-75)GCC>GTC	p.A25V	SETBP1_uc002lay.2_Missense_Mutation_p.A25V	NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	25						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GTCTCCTCAGCCAAGCCCCCA	0.617000									Schinzel-Giedion_syndrome				4	3					0	0	1	0	0	
SETBP1	26040	broad.mit.edu	37	18	42281469	42281469	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:42281469A>G	uc010dni.2	+	2	454	c.158A>G	c.(157-159)GAG>GGG	p.E53G	SETBP1_uc002lay.2_Missense_Mutation_p.E53G	NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	53						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GTGGGCGGAGAGCGCATGGAG	0.622000									Schinzel-Giedion_syndrome				18	27					0	0	1	0	0	
SETBP1	26040	broad.mit.edu	37	18	42531549	42531549	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:42531549C>T	uc010dni.2	+	4	2540	c.2244C>T	c.(2242-2244)CAC>CAT	p.H748H		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	748						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCATCAAGCACCCCAGGCCTG	0.562000									Schinzel-Giedion_syndrome				21	40					0	0	1	0	0	
SETBP1	26040	broad.mit.edu	37	18	42531687	42531687	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:42531687C>T	uc010dni.2	+	4	2678	c.2382C>T	c.(2380-2382)AGC>AGT	p.S794S		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	794						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCCCTGCCAGCACTGAAACCA	0.488000									Schinzel-Giedion_syndrome				26	34					0	0	1	0	0	
TCEB3C	162699	broad.mit.edu	37	18	44555201	44555201	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:44555201C>T	uc010xdb.1	-	1	1249	c.1013G>A	c.(1012-1014)CGC>CAC	p.R338H	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	338	Interaction with elongin BC (By similarity).|Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						GCACTGCTGGCGCAGCGTCGG	0.652000													28	615					0	0	1	0	0	
SMAD2	4087	broad.mit.edu	37	18	45395688	45395688	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:45395688C>T	uc002lcy.2	-	4	694	c.446G>A	c.(445-447)TGC>TAC	p.C149Y	SMAD2_uc002lcz.2_Missense_Mutation_p.C149Y|SMAD2_uc010xdc.1_Missense_Mutation_p.C119Y|SMAD2_uc010xdd.1_Missense_Mutation_p.C119Y	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	149	MH1.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						AGCATATTCGCAGTTTTCAAT	0.388000													11	19					0	0	1	0	0	
ACAA2	10449	broad.mit.edu	37	18	47322226	47322226	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:47322226A>G	uc002ldw.3	-	4	735	c.338T>C	c.(337-339)GTT>GCT	p.V113A	ACAA2_uc002ldx.3_Missense_Mutation_p.V110A	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2	113					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						ACATAAAACAACTTCAGCTTC	0.368000													23	34					0	0	1	0	0	
MAPK4	5596	broad.mit.edu	37	18	48256134	48256134	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:48256134C>T	uc002lev.2	+	6	2674	c.1674C>T	c.(1672-1674)GAC>GAT	p.D558D	MAPK4_uc010xdm.1_Silent_p.D347D|MAPK4_uc010doz.2_3'UTR	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	558					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		ACCTGCCGGACAATAAACTGG	0.617000													3	5					0	0	1	0	0	
DCC	1630	broad.mit.edu	37	18	50936875	50936875	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:50936875A>T	uc002lfe.1	+	20	3576	c.2989A>T	c.(2989-2991)ATG>TTG	p.M997L	DCC_uc010xdr.1_Missense_Mutation_p.M825L|DCC_uc010dpf.1_Missense_Mutation_p.M632L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	997	Extracellular (Potential).|Fibronectin type-III 6.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGACTGGATTATGGAAACAAT	0.363000													52	83					0	0	1	0	0	
CDH20	28316	broad.mit.edu	37	18	59221697	59221697	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:59221697C>T	uc010dps.1	+	11	2187	c.2175C>T	c.(2173-2175)TAC>TAT	p.Y725Y	CDH20_uc002lif.2_Silent_p.Y719Y	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	725	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TCCACAGCTACGTGCTGGCCA	0.657000													10	18					0	0	1	0	0	
KIAA1468	57614	broad.mit.edu	37	18	59855209	59855209	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:59855209C>T	uc002lil.2	+	1	686	c.471C>T	c.(469-471)GGC>GGT	p.G157G	PIGN_uc002lii.3_5'Flank|PIGN_uc002lij.3_5'Flank|KIAA1468_uc002lik.1_Silent_p.G157G|KIAA1468_uc010xel.1_Silent_p.G157G	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	157							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GAGCAGCCGGCGTTGGGGGCG	0.662000											OREG0025032	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	8					0	0	1	0	0	
SERPINB5	5268	broad.mit.edu	37	18	61156698	61156698	+	Splice_Site	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:61156698G>A	uc002liz.3	+	4	566	c.424_splice	c.e4+1	p.G142_splice	SERPINB5_uc002liy.2_Splice_Site_p.G142_splice	NM_002639	NP_002630	P36952	SPB5_HUMAN	serine (or cysteine) proteinase inhibitor, clade						cellular component movement|regulation of proteolysis	cytoplasm|extracellular space	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)	1						CTCACAGATGGCAAGTACCCT	0.378000													19	37					0	0	1	0	0	
SERPINB7	8710	broad.mit.edu	37	18	61463517	61463517	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:61463517C>T	uc002ljl.2	+	5	450	c.354C>T	c.(352-354)GCC>GCT	p.A118A	SERPINB7_uc002ljm.2_Silent_p.A118A|SERPINB7_uc010xet.1_Silent_p.A101A|SERPINB7_uc010dqg.2_Silent_p.A118A	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	118					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				TTGAGTGTGCCGAAAAATTAT	0.308000													16	24					0	0	1	0	0	
SERPINB2	5055	broad.mit.edu	37	18	61570186	61570186	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:61570186A>G	uc010xeu.1	+	9	1228	c.895A>G	c.(895-897)AAA>GAA	p.K299E	SERPINB2_uc002ljo.2_Missense_Mutation_p.K299E|SERPINB2_uc010dqh.2_Missense_Mutation_p.K229E|SERPINB2_uc002ljp.1_Missense_Mutation_p.K104E|SERPINB2_uc002ljq.1_Missense_Mutation_p.K104E	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	299					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CAGCAAAGACAAAATGGCTGA	0.348000													9	34					0	0	1	0	0	
DOK6	220164	broad.mit.edu	37	18	67365809	67365809	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:67365809G>A	uc002lkl.2	+	5	769	c.579G>A	c.(577-579)TGG>TGA	p.W193*		NM_152721	NP_689934	Q6PKX4	DOK6_HUMAN	docking protein 6	193	IRS-type PTB.						insulin receptor binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				ACTCAACGTGGTTCACGTTTG	0.473000													4	37					0	0	1	0	0	
RTTN	25914	broad.mit.edu	37	18	67788837	67788837	+	Silent	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:67788837A>C	uc002lkp.2	-	26	3551	c.3483T>G	c.(3481-3483)TCT>TCG	p.S1161S	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.S249S	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1161							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				GTTCTAGTGAAGAATTTTTTC	0.299000													25	48					0	0	1	0	0	
CBLN2	147381	broad.mit.edu	37	18	70209264	70209264	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:70209264G>A	uc002lku.2	-	2	367	c.132C>T	c.(130-132)CCC>CCT	p.P44P	CBLN2_uc002lkv.2_Silent_p.P44P	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	44	Helical; (Potential).					integral to membrane					0		Esophageal squamous(42;0.131)				GGCAGCAGGCGGGCAGTAGCA	0.582000													13	11					0	0	1	0	0	
KCNG2	26251	broad.mit.edu	37	18	77624158	77624158	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:77624158G>A	uc010xfl.1	+	1	491	c.491G>A	c.(490-492)CGC>CAC	p.R164H		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	164	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		cggcgccTGCGCGACGTGGTG	0.368000													7	8					0	0	1	0	0	
PQLC1	80148	broad.mit.edu	37	18	77679291	77679291	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:77679291G>A	uc002lnl.2	-	5	673	c.501C>T	c.(499-501)TCC>TCT	p.S167S	PQLC1_uc010dre.2_Silent_p.S84S|PQLC1_uc002lnk.2_Silent_p.S149S|PQLC1_uc010xfm.1_Intron	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	167						integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		CAAACAGGGCGGAGTCAATGG	0.637000													20	33					0	0	1	0	0	
C18orf22	79863	broad.mit.edu	37	18	77798609	77798609	+	Silent	SNP	G	A	A	rs143262320	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:77798609G>A	uc002lns.2	+	4	621	c.483G>A	c.(481-483)GCG>GCA	p.A161A	C18orf22_uc010drh.2_Silent_p.A161A|C18orf22_uc010dri.1_Intron|C18orf22_uc002lnt.2_5'Flank	NM_024805	NP_079081	Q8N0V3	RBFA_HUMAN	hypothetical protein LOC79863 precursor	161					rRNA processing	mitochondrion					0		all_cancers(4;3.21e-14)|all_epithelial(4;7.11e-09)|all_lung(4;0.00366)|Lung NSC(4;0.00683)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0545)|all_hematologic(56;0.15)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;6.46e-08)|BRCA - Breast invasive adenocarcinoma(31;0.00376)		GAAGTGCCGCGCACATGAGGT	0.498000													24	41					0	0	1	0	0	
HCN2	610	broad.mit.edu	37	19	608110	608110	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:608110C>T	uc002lpe.2	+	4	1418	c.1365C>T	c.(1363-1365)TAC>TAT	p.Y455Y		NM_001194	NP_001185	Q9UL51	HCN2_HUMAN	hyperpolarization activated cyclic	455	Helical; Name=Segment S6; (Potential).				cell-cell signaling|muscle contraction	voltage-gated potassium channel complex	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity				0		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCTGCTACGCCATGTTCA	0.662000													64	23					0	0	1	0	0	
MED16	10025	broad.mit.edu	37	19	871999	871999	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:871999C>T	uc002lqd.1	-	12	2176	c.2025G>A	c.(2023-2025)GTG>GTA	p.V675V	MED16_uc010drw.1_Intron|MED16_uc002lqe.2_Silent_p.V664V|MED16_uc002lqf.2_Silent_p.V664V	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	675	WD 4.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCCGTATACACGGGCAGGC	0.592000													17	28					0	0	1	0	0	
SBNO2	22904	broad.mit.edu	37	19	1123582	1123582	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:1123582C>T	uc002lrk.3	-	7	817	c.579G>A	c.(577-579)GCG>GCA	p.A193A	SBNO2_uc002lrj.3_Silent_p.A136A|SBNO2_uc010dse.2_Silent_p.A186A|SBNO2_uc010xgj.1_Silent_p.A136A|SBNO2_uc010dsf.2_Silent_p.A136A	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	193	Poly-Glu.				macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCAGctcctccgcctcctcct	0.527000													23	10					0	0	1	0	0	
PCSK4	54760	broad.mit.edu	37	19	1483414	1483414	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:1483414G>A	uc002ltb.1	-	12	1502	c.1440C>T	c.(1438-1440)GCC>GCT	p.A480A	PCSK4_uc002lsz.2_5'UTR|PCSK4_uc002lta.2_Silent_p.A292A	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	480					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGGAGGCCGGCGCAGGCCG	0.682000													4	47					0	0	1	0	0	
S1PR4	8698	broad.mit.edu	37	19	3179235	3179235	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:3179235C>T	uc002lxg.2	+	1	470	c.445C>T	c.(445-447)CGG>TGG	p.R149W		NM_003775	NP_003766	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4 precursor	149	Cytoplasmic (By similarity).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|skin(1)	2						CACCATGGTGCGGCCGGTGGC	0.692000													74	15					0	0	1	0	0	
TJP3	27134	broad.mit.edu	37	19	3730369	3730369	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:3730369G>A	uc010xhv.1	+	4	335	c.335G>A	c.(334-336)CGG>CAG	p.R112Q	TJP3_uc010xhs.1_Missense_Mutation_p.R93Q|TJP3_uc010xht.1_Missense_Mutation_p.R57Q|TJP3_uc010xhu.1_Missense_Mutation_p.R102Q|TJP3_uc010xhw.1_Missense_Mutation_p.R112Q	NM_014428	NP_055243	O95049	ZO3_HUMAN	tight junction protein 3	93	PDZ 1.					tight junction	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AAACGTCCCCGGAGGATCCAC	0.557000													4	5					0	0	1	0	0	
ANKRD24	170961	broad.mit.edu	37	19	4207553	4207553	+	Missense_Mutation	SNP	G	A	A	rs146188452	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:4207553G>A	uc010dtt.1	+	9	869	c.593G>A	c.(592-594)CGT>CAT	p.R198H	ANKRD24_uc002lzs.2_Missense_Mutation_p.R169H|ANKRD24_uc002lzt.2_Missense_Mutation_p.R170H	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	198	ANK 4.										0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		GACCTGTGCCGTCTCCTACTG	0.493000											OREG0025162	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	78					0	0	1	0	0	
SEMA6B	10501	broad.mit.edu	37	19	4556000	4556000	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:4556000G>A	uc010duc.1	-	5	509	c.471C>T	c.(469-471)AGC>AGT	p.S157S	SEMA6B_uc010dud.2_Silent_p.S157S|SEMA6B_uc010xih.1_Silent_p.S157S	NM_032108	NP_115484	Q9H3T3	SEM6B_HUMAN	semaphorin 6B precursor	157	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGACTCACGCTGTAGTTGG	0.592000													77	12					0	0	1	0	0	
INSR	3643	broad.mit.edu	37	19	7143042	7143042	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:7143042G>A	uc002mgd.1	-	12	2436	c.2327C>T	c.(2326-2328)ACG>ATG	p.T776M	INSR_uc002mge.1_Missense_Mutation_p.T764M	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	776	Fibronectin type-III 2.|Extracellular (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGCTGCCACCGTGGGCACGGC	0.582000													22	37					0	0	1	0	0	
INSR	3643	broad.mit.edu	37	19	7170609	7170609	+	Silent	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:7170609T>A	uc002mgd.1	-	6	1531	c.1422A>T	c.(1420-1422)GGA>GGT	p.G474G	INSR_uc002mge.1_Silent_p.G474G|INSR_uc002mgf.2_Silent_p.G474G	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	474					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCCCCTTGGTTCCTGAAACTT	0.428000													12	200					0	0	1	0	0	
ARHGEF18	23370	broad.mit.edu	37	19	7521235	7521235	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:7521235C>T	uc002mgi.2	+	8	1816	c.1563C>T	c.(1561-1563)ACC>ACT	p.T521T	ARHGEF18_uc010xjm.1_Silent_p.T363T|ARHGEF18_uc002mgh.2_Silent_p.T363T|ARHGEF18_uc002mgj.1_Silent_p.T164T	NM_001130955	NP_001124427	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor 18	521	PH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1		Renal(5;0.0902)				TCCTGCTGACCGACGTACTTT	0.458000													350	80					0	0	1	0	0	
ZNF358	140467	broad.mit.edu	37	19	7585043	7585043	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:7585043G>A	uc002mgn.2	+	2	1085	c.915G>A	c.(913-915)GCG>GCA	p.A305A	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	305	C2H2-type 6.				embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						AGAGCTCGGCGCTGCTGCAGC	0.701000													30	8					0	0	1	0	0	
LRRC8E	80131	broad.mit.edu	37	19	7963631	7963631	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:7963631G>A	uc002mir.2	+	3	325	c.224G>A	c.(223-225)CGG>CAG	p.R75Q		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	75						integral to membrane				lung(1)|pancreas(1)	2						TTGCTGCCTCGGGGGATCCCT	0.507000													113	20					0	0	1	0	0	
ADAMTS10	81794	broad.mit.edu	37	19	8651494	8651494	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:8651494T>C	uc002mkj.1	-	20	2625	c.2351A>G	c.(2350-2352)CAG>CGG	p.Q784R	ADAMTS10_uc002mki.1_Missense_Mutation_p.Q271R|ADAMTS10_uc002mkk.1_Missense_Mutation_p.Q416R	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1	784	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			pancreas(2)|skin(2)	4						GCTCTGGACCTGGTCTGGCCC	0.617000											OREG0025221	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	66	18					0	0	1	0	0	
MUC16	94025	broad.mit.edu	37	19	9083880	9083880	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:9083880C>T	uc002mkp.2	-	1	8139	c.7935G>A	c.(7933-7935)CCG>CCA	p.P2645P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2645	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGGAGTGTCCGGGAGTAAAG	0.493000													10	25					0	0	1	0	0	
OR1M1	125963	broad.mit.edu	37	19	9204168	9204168	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:9204168T>C	uc010xkj.1	+	1	248	c.248T>C	c.(247-249)GTG>GCG	p.V83A		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	83	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						AAGATGCTGGTGAGCCTTCAA	0.532000													38	21					0	0	1	0	0	
C19orf66	55337	broad.mit.edu	37	19	10200705	10200705	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:10200705C>T	uc002mmu.3	+	5	664	c.366C>T	c.(364-366)CGC>CGT	p.R122R	C19orf66_uc002mmv.3_Silent_p.R122R|C19orf66_uc002mmw.3_Silent_p.R71R	NM_018381	NP_060851	Q9NUL5	CS066_HUMAN	hypothetical protein LOC55337	122											0						GGTGGCGCCGCGTGCCCCAGC	0.577000													3	10					0	0	1	0	0	
CDKN2D	1032	broad.mit.edu	37	19	10677960	10677960	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:10677960A>G	uc002mpa.2	-	2	577	c.275T>C	c.(274-276)GTC>GCC	p.V92A	KRI1_uc002mox.1_5'Flank|KRI1_uc002moy.1_5'Flank|CDKN2D_uc002mpb.2_Missense_Mutation_p.V92A	NM_001800	NP_001791	P55273	CDN2D_HUMAN	cyclin-dependent kinase inhibitor 2D	92	ANK 2.				anti-apoptosis|autophagic cell death|cell cycle arrest|DNA synthesis involved in DNA repair|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of caspase activity|negative regulation of cell growth|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|response to retinoic acid|response to UV|response to vitamin D	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding				0			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CTCCACTAGGACCTTCAGGGT	0.597000									Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System				98	24					0	0	1	0	0	
MAN2B1	4125	broad.mit.edu	37	19	12772078	12772078	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:12772078G>A	uc002mub.2	-	7	1098	c.1022C>T	c.(1021-1023)GCG>GTG	p.A341V	MAN2B1_uc010dyv.1_Missense_Mutation_p.A341V	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	341					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						ACTGACCTGCGCATTTACCAG	0.517000													28	74					0	0	1	0	0	
PRDX2	7001	broad.mit.edu	37	19	12910705	12910705	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:12910705T>C	uc002mvd.2	-	5	629	c.479A>G	c.(478-480)CAG>CGG	p.Q160R		NM_005809	NP_005800	P32119	PRDX2_HUMAN	peroxiredoxin 2 isoform a	160	Thioredoxin.				anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity				0						CTGGAAGGCCTGGACCAGCCG	0.502000													66	15					0	0	1	0	0	
GCDH	2639	broad.mit.edu	37	19	13008170	13008170	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:13008170C>T	uc002mvq.2	+	10	1087	c.1010C>T	c.(1009-1011)GCA>GTA	p.A337V	GCDH_uc010xms.1_Missense_Mutation_p.A304V|GCDH_uc002mvp.2_Missense_Mutation_p.A337V|GCDH_uc010xmt.1_Missense_Mutation_p.A171V|GCDH_uc010xmu.1_Missense_Mutation_p.A293V	NM_000159	NP_000150	Q92947	GCDH_HUMAN	glutaryl-Coenzyme A dehydrogenase isoform a	337					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding				0						AAGAAGCTGGCAGACATGCTC	0.622000													17	36					0	0	1	0	0	
CC2D1A	54862	broad.mit.edu	37	19	14034191	14034191	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:14034191C>T	uc002mxo.2	+	15	1986	c.1687C>T	c.(1687-1689)CGG>TGG	p.R563W	CC2D1A_uc002mxp.2_Missense_Mutation_p.R563W|CC2D1A_uc010dzh.2_Missense_Mutation_p.R132W|CC2D1A_uc002mxq.1_Missense_Mutation_p.R208W	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	563					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			CCTGGTCCAGCGGCCTGGCCC	0.687000													4	80					0	0	1	0	0	
PRKACA	5566	broad.mit.edu	37	19	14217673	14217673	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:14217673G>A	uc002myc.2	-	3	336	c.136C>T	c.(136-138)CGA>TGA	p.R46*	PRKACA_uc002myb.2_Nonsense_Mutation_p.R38*|PRKACA_uc010xnm.1_Translation_Start_Site|PRKACA_uc002myd.2_Translation_Start_Site	NM_002730	NP_002721	P17612	KAPCA_HUMAN	cAMP-dependent protein kinase catalytic subunit	46	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			lung(1)	1						GTCTTGATTCGTTCAAACTGA	0.602000													66	18					0	0	1	0	0	
BRD4	23476	broad.mit.edu	37	19	15355182	15355182	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:15355182C>T	uc002nar.2	-	13	2663	c.2441G>A	c.(2440-2442)GGC>GAC	p.G814D		NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	814					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			AAAGACGCTGCCTGGGAGCTG	0.667000			T	NUT|C15orf55	lethal midline carcinoma of young people								3	13					0	0	1	0	0	
WIZ	58525	broad.mit.edu	37	19	15536330	15536330	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:15536330G>A	uc002nbc.2	-	5	1876	c.1853C>T	c.(1852-1854)ACC>ATC	p.T618I	WIZ_uc002nba.3_Missense_Mutation_p.T485I|WIZ_uc002nbb.3_Missense_Mutation_p.T444I	NM_021241	NP_067064	O95785	WIZ_HUMAN	widely-interspaced zinc finger motifs	1301						nucleus	zinc ion binding				0						AGGGGCCACGGTGGGAGGCCC	0.697000													8	8					0	0	1	0	0	
CYP4F12	66002	broad.mit.edu	37	19	15795637	15795637	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:15795637G>A	uc002nbl.2	+	8	991	c.930G>A	c.(928-930)GGG>GGA	p.G310G		NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					ATGAAGATGGGAAGGCATTGT	0.388000													22	40					0	0	1	0	0	
HSH2D	84941	broad.mit.edu	37	19	16268143	16268143	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:16268143C>T	uc002ndp.3	+	8	1129	c.598C>T	c.(598-600)CGC>TGC	p.R200C	HSH2D_uc002ndr.2_Missense_Mutation_p.R143C|HSH2D_uc010ead.2_RNA	NM_032855	NP_116244	Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	200						cytoplasm|nucleus					0						TGGAGAGACCCGCCAGAAACT	0.552000													21	31					0	0	1	0	0	
ABHD8	79575	broad.mit.edu	37	19	17411739	17411739	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:17411739C>T	uc002ngb.3	-	2	927	c.687G>A	c.(685-687)GCG>GCA	p.A229A		NM_024527	NP_078803	Q96I13	ABHD8_HUMAN	abhydrolase domain containing 8	229							hydrolase activity				0						CCTCAGCCAGCGCATAGAAGG	0.602000													50	72					0	0	1	0	0	
GLT25D1	79709	broad.mit.edu	37	19	17683348	17683348	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:17683348C>T	uc002nhc.1	+	6	898	c.886C>T	c.(886-888)CGC>TGC	p.R296C	GLT25D1_uc010eax.1_Intron	NM_024656	NP_078932	Q8NBJ5	GT251_HUMAN	glycosyltransferase 25 domain containing 1	296					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity				0						AGTGCCATTGCGCGCCCACAG	0.557000													33	70					0	0	1	0	0	
B3GNT3	10331	broad.mit.edu	37	19	17922600	17922600	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:17922600G>A	uc002nhk.1	+	3	873	c.788G>A	c.(787-789)CGG>CAG	p.R263Q	B3GNT3_uc002nhl.1_Missense_Mutation_p.R263Q|B3GNT3_uc010ebd.1_Missense_Mutation_p.R263Q|B3GNT3_uc010ebe.1_Missense_Mutation_p.R263Q	NM_014256	NP_055071	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal	263	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			upper_aerodigestive_tract(1)	1						CAGAATGAGCGGTACCCACCC	0.602000													33	45					0	0	1	0	0	
JAK3	3718	broad.mit.edu	37	19	17948862	17948862	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:17948862A>C	uc002nhn.3	-	12	1680	c.1580T>G	c.(1579-1581)CTG>CGG	p.L527R	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.L527R	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	527	Protein kinase 1.		L -> P (in a gastric adenocarcinoma sample; somatic mutation).		B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding	p.L527P(1)		haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CCCATGGCCCAGGTTCTCATG	0.572000		2	Mis		acute megakaryocytic leukemia|								44	52					0	0	1	0	0	
KCNN1	3780	broad.mit.edu	37	19	18092827	18092827	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:18092827A>G	uc002nht.2	+	5	1118	c.808A>G	c.(808-810)ACG>GCG	p.T270A	KCNN1_uc010xqa.1_Missense_Mutation_p.T270A	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	270					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						CACCTTCAACACGCGCTTCGT	0.612000													5	7					0	0	1	0	0	
KIAA1683	80726	broad.mit.edu	37	19	18378115	18378115	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:18378115C>T	uc002nin.2	-	3	451	c.235G>A	c.(235-237)GTC>ATC	p.V79I	KIAA1683_uc010ebn.2_Missense_Mutation_p.V79I|KIAA1683_uc010xqe.1_Missense_Mutation_p.V33I	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	79						mitochondrion				ovary(2)	2						AGGCGTGGGACGCGGCGGGAC	0.632000													7	96					0	0	1	0	0	
GDF15	9518	broad.mit.edu	37	19	18499097	18499097	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:18499097G>A	uc002niv.2	+	2	311	c.279G>A	c.(277-279)GTG>GTA	p.V93V		NM_004864	NP_004855	Q99988	GDF15_HUMAN	growth differentiation factor 15	93					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)	1						TTCCCACAGTGCGGCTGGGAT	0.577000											OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	24					0	0	1	0	0	
ELL	8178	broad.mit.edu	37	19	18569015	18569015	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:18569015C>T	uc002njh.2	-	6	941	c.869G>A	c.(868-870)CGG>CAG	p.R290Q	ELL_uc010ebq.2_Missense_Mutation_p.R233Q|ELL_uc002njg.2_Missense_Mutation_p.R157Q	NM_006532	NP_006523	P55199	ELL_HUMAN	elongation factor RNA polymerase II	290					positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	Cajal body|nuclear speck|transcription elongation factor complex	protein binding			lung(1)	1				GBM - Glioblastoma multiforme(1328;7.81e-07)		GCGGCATTACCGGACGAGCAC	0.627000			T	MLL	AL								21	35					0	0	1	0	0	
KLHL26	55295	broad.mit.edu	37	19	18779108	18779108	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:18779108C>T	uc002njz.1	+	3	928	c.901C>T	c.(901-903)CGC>TGC	p.R301C		NM_018316	NP_060786	Q53HC5	KLH26_HUMAN	kelch-like 26	301										ovary(1)	1						GCAGTCTCCGCGCACCGCCGT	0.662000													30	45					0	0	1	0	0	
SFRS14	10147	broad.mit.edu	37	19	19112468	19112468	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:19112468C>T	uc002nkx.2	-	8	3091	c.2945G>A	c.(2944-2946)CGA>CAA	p.R982Q	SFRS14_uc002nkz.1_Missense_Mutation_p.R996Q|SFRS14_uc002nla.1_Missense_Mutation_p.R982Q|SFRS14_uc002nlb.2_Missense_Mutation_p.R982Q|SFRS14_uc010xqk.1_Missense_Mutation_p.R751Q	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	982					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			ATAGGCAATTCGAACTGGTTC	0.403000													25	34					0	0	1	0	0	
HAPLN4	404037	broad.mit.edu	37	19	19371881	19371881	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:19371881G>A	uc002nmb.2	-	3	280	c.225C>T	c.(223-225)GCC>GCT	p.A75A	HAPLN4_uc002nmc.2_Silent_p.A75A	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	75	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			GACCGTGGGCGGCTGCCTCAT	0.662000													17	21					0	0	1	0	0	
ATP13A1	57130	broad.mit.edu	37	19	19762529	19762529	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:19762529G>A	uc002nnh.3	-	17	2332	c.2304C>T	c.(2302-2304)CAC>CAT	p.H768H	ATP13A1_uc002nne.2_5'UTR|ATP13A1_uc002nnf.3_Silent_p.H136H|ATP13A1_uc002nng.2_Silent_p.H650H	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	ATPase type 13A1	768	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(3)|large_intestine(2)|central_nervous_system(1)	6						GGATCAGCGTGTGGGCCTTTT	0.612000													24	22					0	0	1	0	0	
ZNF90	7643	broad.mit.edu	37	19	20236314	20236314	+	RNA	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:20236314T>A	uc002nos.1	+	5		c.990T>A			ZNF90_uc002not.1_RNA			Q03938	ZNF90_HUMAN	Synthetic construct DNA, clone: pF1KB9685, Homo sapiens ZNF90 gene for zinc finger protein 90, without stop codon, in Flexi system.							Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						ACTATCAAAATTCACCTGTAT	0.388000													6	14					0	0	1	0	0	
ZNF208	7757	broad.mit.edu	37	19	22155896	22155896	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:22155896A>C	uc002nqp.2	-	5	1789	c.1640T>G	c.(1639-1641)ATT>AGT	p.I547S	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAGACCTTAATAAAGGTTTT	0.398000													5	66					0	0	1	0	0	
C19orf2	8725	broad.mit.edu	37	19	30500156	30500156	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:30500156G>A	uc002nsr.2	+	8	961	c.931G>A	c.(931-933)GAC>AAC	p.D311N	C19orf2_uc002nsq.2_Missense_Mutation_p.D293N|C19orf2_uc002nss.2_Missense_Mutation_p.D271N|C19orf2_uc002nst.2_Missense_Mutation_p.D235N	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	311	Poly-Asp.			Missing (in Ref. 1; AAD08679, 2; BAF84859 and 4; BAA34781).	protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		cgacgacgacgacaacattga	0.254000													11	20					0	0	1	0	0	
ZNF536	9745	broad.mit.edu	37	19	30934862	30934862	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:30934862G>A	uc002nsu.1	+	2	531	c.393G>A	c.(391-393)CCG>CCA	p.P131P	ZNF536_uc010edd.1_Silent_p.P131P	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	131	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCAAGTACCCGTGCCCACTCT	0.627000													24	22					0	0	1	0	0	
TSHZ3	57616	broad.mit.edu	37	19	31767913	31767913	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:31767913G>A	uc002nsy.3	-	2	2851	c.2786C>T	c.(2785-2787)CCC>CTC	p.P929L		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	929	Homeobox; atypical.				negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					CCGCTCCTGGGGGCTCAGGTC	0.592000													17	26					0	0	1	0	0	
ATP4A	495	broad.mit.edu	37	19	36046232	36046232	+	Missense_Mutation	SNP	G	A	A	rs145835787		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36046232G>A	uc002oal.1	-	15	2191	c.2162C>T	c.(2161-2163)GCG>GTG	p.A721V	ATP4A_uc010eee.1_5'UTR	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	721	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GGCCACAATCGCACCCTGCAG	0.642000													8	23					0	0	1	0	0	
HAUS5	23354	broad.mit.edu	37	19	36106176	36106176	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36106176C>T	uc002oam.1	+	6	424	c.373C>T	c.(373-375)CGA>TGA	p.R125*		NM_015302	NP_056117	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	125					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle					0						CACCCAGCGTCGAGCTCTCCT	0.632000													6	18					0	0	1	0	0	
MLL4	9757	broad.mit.edu	37	19	36223432	36223432	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36223432G>A	uc010eei.2	+	29	5982	c.5982G>A	c.(5980-5982)GCG>GCA	p.A1994A		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1994					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGACTTCGCGGCCAGCCTGC	0.677000													16	40					0	0	1	0	0	
TMEM149	79713	broad.mit.edu	37	19	36230720	36230720	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36230720G>A	uc002obc.2	-	4	713	c.612C>T	c.(610-612)TGC>TGT	p.C204C	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Silent_p.C204C|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Silent_p.C284C	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	204	Cytoplasmic (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGGGACTCCGCAGACCAAGC	0.602000													58	91					0	0	1	0	0	
NPHS1	4868	broad.mit.edu	37	19	36333366	36333366	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36333366T>C	uc002oby.2	-	18	2421	c.2421A>G	c.(2419-2421)AAA>AAG	p.K807K		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	807	Ig-like C2-type 7.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCTGGGCCAGTTTGGCATGGT	0.592000													50	76					0	0	1	0	0	
NPHS1	4868	broad.mit.edu	37	19	36339017	36339017	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36339017G>A	uc002oby.2	-	11	1366	c.1366C>T	c.(1366-1368)CGG>TGG	p.R456W		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	456	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTCCCAGCCCGGAGCTTCTGG	0.622000													28	71					0	0	1	0	0	
KIRREL2	84063	broad.mit.edu	37	19	36351456	36351456	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36351456G>A	uc002ocb.3	+	7	1027	c.815G>A	c.(814-816)CGC>CAC	p.R272H	KIRREL2_uc002obz.3_Missense_Mutation_p.R272H|KIRREL2_uc002oca.3_Missense_Mutation_p.R222H|KIRREL2_uc002occ.3_Missense_Mutation_p.R219H|KIRREL2_uc002ocd.3_Missense_Mutation_p.R269H	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	272	Ig-like C2-type 3.|Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTCGGGGCCCGCGGGCCAAGG	0.652000													34	52					0	0	1	0	0	
APLP1	333	broad.mit.edu	37	19	36370282	36370282	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36370282G>A	uc002oce.2	+	17	2030	c.1892G>A	c.(1891-1893)CGC>CAC	p.R631H	APLP1_uc010xsz.1_Missense_Mutation_p.R592H|APLP1_uc002ocf.2_Missense_Mutation_p.R632H|APLP1_uc002ocg.2_Missense_Mutation_p.R535H|APLP1_uc010xta.1_Missense_Mutation_p.R625H	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	631	Cytoplasmic (Potential).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGCAGCTCCGCGAACTGCAG	0.667000													19	68					0	0	1	0	0	
ZNF567	163081	broad.mit.edu	37	19	37211524	37211524	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:37211524T>G	uc010xtl.1	+	6	2120	c.1898T>G	c.(1897-1899)ATT>AGT	p.I633S	ZNF567_uc002oep.3_Missense_Mutation_p.I602S|ZNF567_uc002oeq.1_Intron	NM_152603	NP_689816	Q8N184	ZN567_HUMAN	zinc finger protein 567	633	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AGAAACCTCATTGTCCATCAA	0.333000													27	32					0	0	1	0	0	
ZNF607	84775	broad.mit.edu	37	19	38190535	38190535	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:38190535C>T	uc002ohc.1	-	5	1093	c.497G>A	c.(496-498)CGT>CAT	p.R166H	ZNF607_uc002ohb.1_Missense_Mutation_p.R165H	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			AGGTTTCTCACGAGCATTAAT	0.383000													32	54					0	0	1	0	0	
MAP4K1	11184	broad.mit.edu	37	19	39108029	39108029	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:39108029G>A	uc002oix.1	-	3	321	c.213C>T	c.(211-213)CAC>CAT	p.H71H	MAP4K1_uc002oiy.1_Silent_p.H71H|EIF3K_uc010xuh.1_5'Flank|EIF3K_uc002oiz.1_5'Flank|EIF3K_uc010xui.1_5'Flank	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	71	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGATGTTGGCGTGCCGGCAAG	0.557000													28	46					0	0	1	0	0	
CAPN12	147968	broad.mit.edu	37	19	39233692	39233692	+	Silent	SNP	G	A	A	rs149932497		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:39233692G>A	uc002ojd.1	-	2	597	c.288C>T	c.(286-288)GAC>GAT	p.D96D		NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	96	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			CCTGACACACGTCTGTGCGGC	0.522000													25	48					0	0	1	0	0	
LRFN1	57622	broad.mit.edu	37	19	39798594	39798594	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:39798594G>A	uc002okw.2	-	2	1995	c.1995C>T	c.(1993-1995)GCC>GCT	p.A665A		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	665	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGCCCACCGCGGCCCGAGACT	0.721000													3	7					0	0	1	0	0	
SUPT5H	6829	broad.mit.edu	37	19	39963854	39963854	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:39963854G>A	uc002olo.3	+	24	2449	c.2270G>A	c.(2269-2271)CGC>CAC	p.R757H	SUPT5H_uc002olp.3_Missense_Mutation_p.R757H|SUPT5H_uc002olq.3_Missense_Mutation_p.R753H|SUPT5H_uc002oln.3_Missense_Mutation_p.R757H|SUPT5H_uc002olr.3_Missense_Mutation_p.R757H|SUPT5H_uc002ols.1_Missense_Mutation_p.R380H|SUPT5H_uc010egp.1_Silent_p.A122A	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	757	9 X 7 AA approximate tandem repeats of G- S-[QR]-T-P-X-[YQ], motif CTR1.|CTR1-1; approximate.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGCTCACGGCGCCCGGGCGGC	0.667000													24	34					0	0	1	0	0	
FCGBP	8857	broad.mit.edu	37	19	40364397	40364397	+	Missense_Mutation	SNP	C	T	T	rs148917660	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:40364397C>T	uc002omp.3	-	31	14253	c.14245G>A	c.(14245-14247)GGT>AGT	p.G4749S		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4749	TIL 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CAGGAGTCACCGCAGAGCTCA	0.647000													15	21					0	0	1	0	0	
FCGBP	8857	broad.mit.edu	37	19	40424533	40424533	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:40424533G>A	uc002omp.3	-	4	1678	c.1670C>T	c.(1669-1671)TCG>TTG	p.S557L		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	557	VWFD 1.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TGGCAGGCGCGAGCGCTGGTT	0.582000													5	10					0	0	1	0	0	
HIPK4	147746	broad.mit.edu	37	19	40886655	40886655	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:40886655G>A	uc002onp.2	-	3	1528	c.1243C>T	c.(1243-1245)CGA>TGA	p.R415*		NM_144685	NP_653286	Q8NE63	HIPK4_HUMAN	homeodomain interacting protein kinase 4	415						cytoplasm	ATP binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2			Lung(22;4.95e-05)|LUSC - Lung squamous cell carcinoma(20;0.000292)			TTCTCCTCTCGGAAGAAGGGG	0.632000													35	69					0	0	1	0	0	
PRX	57716	broad.mit.edu	37	19	40900561	40900561	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:40900561G>A	uc002onr.2	-	7	3967	c.3698C>T	c.(3697-3699)GCG>GTG	p.A1233V	PRX_uc002onq.2_Missense_Mutation_p.A1094V|PRX_uc002ons.2_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	1233	Glu-rich (acidic).				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGCCTCGCCCGCCTGTGCCTC	0.682000													27	34					0	0	1	0	0	
LTBP4	8425	broad.mit.edu	37	19	41116547	41116547	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:41116547C>G	uc002ooh.1	+	15	1995	c.1995C>G	c.(1993-1995)CAC>CAG	p.H665Q	LTBP4_uc002oog.1_Missense_Mutation_p.H628Q|LTBP4_uc002ooi.1_Missense_Mutation_p.H598Q|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc010xvo.1_Missense_Mutation_p.T37R|LTBP4_uc010ehb.1_5'Flank|LTBP4_uc002ook.1_5'Flank|LTBP4_uc002ool.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	665	Cys-rich.|EGF-like 5; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGCACCGCACGGAGCCAGCT	0.687000													6	11					0	0	1	0	0	
LTBP4	8425	broad.mit.edu	37	19	41133678	41133678	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:41133678G>A	uc002ooh.1	+	33	4636	c.4636G>A	c.(4636-4638)GGC>AGC	p.G1546S	LTBP4_uc002oog.1_Missense_Mutation_p.G1509S|LTBP4_uc002ooi.1_Missense_Mutation_p.G1479S|LTBP4_uc002ooj.1_Missense_Mutation_p.G419S|LTBP4_uc002ook.1_Missense_Mutation_p.G680S|LTBP4_uc002ool.1_Missense_Mutation_p.G558S|LTBP4_uc010xvp.1_Missense_Mutation_p.G306S	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1546	EGF-like 15.			G -> D (in Ref. 1; CAA73944).	growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTGCACCAACGGCCGCTGCGT	0.682000													3	6					0	0	1	0	0	
NUMBL	9253	broad.mit.edu	37	19	41188655	41188655	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:41188655C>T	uc002oon.2	-	5	545	c.377G>A	c.(376-378)CGA>CAA	p.R126Q	NUMBL_uc010xvq.1_Missense_Mutation_p.R85Q|NUMBL_uc002ooo.2_Missense_Mutation_p.R126Q|NUMBL_uc010xvr.1_Missense_Mutation_p.R85Q	NM_004756	NP_004747	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	126	PID.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			lung(3)|ovary(1)|breast(1)	5			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			GTCCACCACTCGGAGCCCATC	0.652000													4	41					0	0	1	0	0	
ADCK4	79934	broad.mit.edu	37	19	41211331	41211331	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:41211331G>A	uc002oor.2	-	6	691	c.389C>T	c.(388-390)TCC>TTC	p.S130F	ADCK4_uc002ooq.1_Intron|ADCK4_uc002oos.2_Missense_Mutation_p.S130F	NM_024876	NP_079152	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4 isoform a	130						integral to membrane	protein serine/threonine kinase activity				0			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			GAAGGGGCTGGAGTCCAGCCC	0.468000													35	60					0	0	1	0	0	
CYP2A7	1549	broad.mit.edu	37	19	41386063	41386063	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:41386063C>T	uc002opm.2	-	4	1122	c.580G>A	c.(580-582)GAG>AAG	p.E194K	CYP2A7_uc002opo.2_Missense_Mutation_p.E194K|CYP2A7_uc002opn.2_Missense_Mutation_p.E143K	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	194						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TCTTTGTCCTCATAGTCAAAG	0.562000													6	72					0	0	1	0	0	
AXL	558	broad.mit.edu	37	19	41758814	41758814	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:41758814T>C	uc010ehj.2	+	16	2058	c.1868T>C	c.(1867-1869)ATG>ACG	p.M623T	CYP2F1_uc010xvw.1_Intron|AXL_uc010ehk.2_Missense_Mutation_p.M614T	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	623	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						TTACCTTTCATGAAACATGGA	0.493000													30	73					0	0	1	0	0	
CCDC97	90324	broad.mit.edu	37	19	41826288	41826288	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:41826288C>T	uc002oqg.2	+	4	946	c.824C>T	c.(823-825)TCG>TTG	p.S275L	CYP2F1_uc010xvw.1_Intron	NM_052848	NP_443080	Q96F63	CCD97_HUMAN	coiled-coil domain containing 97	275											0						GTTCCCGACTCGGAGGAGAGG	0.632000													21	41					0	0	1	0	0	
CEACAM5	1048	broad.mit.edu	37	19	42219022	42219022	+	Missense_Mutation	SNP	C	T	T	rs113097830	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:42219022C>T	uc002ork.2	+	3	678	c.557C>T	c.(556-558)CCG>CTG	p.P186L	CEACAM5_uc010ehz.1_Missense_Mutation_p.P186L|CEACAM5_uc002orj.1_Missense_Mutation_p.P186L|CEACAM5_uc002orl.2_Missense_Mutation_p.P186L	NM_004363	NP_004354	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion	186	Ig-like 2.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				skin(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CAGAGCCTCCCGGTCAGTCCC	0.522000													75	127					0	0	1	0	0	
DMRTC2	63946	broad.mit.edu	37	19	42354689	42354689	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:42354689A>G	uc002ors.2	+	8	995	c.912A>G	c.(910-912)TCA>TCG	p.S304S	DMRTC2_uc002orr.1_Silent_p.S232S|DMRTC2_uc010xwe.1_Silent_p.S355S	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	304	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						TGAAAGATTCATCCCAGGCTC	0.642000													23	38					0	0	1	0	0	
ARHGEF1	9138	broad.mit.edu	37	19	42398554	42398554	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:42398554G>T	uc002orx.2	+	10	884	c.775G>T	c.(775-777)GCC>TCC	p.A259S	ARHGEF1_uc002orw.1_Missense_Mutation_p.A259S|ARHGEF1_uc002ory.2_Missense_Mutation_p.A226S|ARHGEF1_uc002orz.2_Missense_Mutation_p.A97S|ARHGEF1_uc002osa.2_Missense_Mutation_p.A274S|ARHGEF1_uc002osb.2_Missense_Mutation_p.A241S|ARHGEF1_uc002osc.2_5'Flank|ARHGEF1_uc002osd.2_5'Flank	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	259				EPA -> DPP (in Ref. 1; AAB17896).	cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GGACGAGCCTGCCAAGACCAA	0.627000													13	35					6.31663e-08	6.5166e-08	1	1	0	
DEDD2	162989	broad.mit.edu	37	19	42703893	42703893	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:42703893C>T	uc002osu.1	-	5	746	c.678G>A	c.(676-678)GCG>GCA	p.A226A	DEDD2_uc002osv.1_RNA|DEDD2_uc002osw.1_Silent_p.A221A|DEDD2_uc002osx.1_3'UTR|DEDD2_uc002osy.1_Silent_p.A226A	NM_133328	NP_579874	Q8WXF8	DEDD2_HUMAN	death effector domain-containing  DNA binding	226					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity				0		Prostate(69;0.0704)				CCAGCTGCCGCGCCAGCGCCT	0.657000													7	9					0	0	1	0	0	
ZNF526	116115	broad.mit.edu	37	19	42729656	42729656	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:42729656C>T	uc002osz.1	+	3	1257	c.1101C>T	c.(1099-1101)CGC>CGT	p.R367R		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	367	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				ACTGTGGCCGCGGCTTTGGCA	0.597000													31	42					0	0	1	0	0	
LIPE	3991	broad.mit.edu	37	19	42911849	42911849	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:42911849G>A	uc002otr.2	-	5	2028	c.1751C>T	c.(1750-1752)ACG>ATG	p.T584M	uc010eif.1_Intron	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	584					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				GACCGTGAGCGTGGGGTCGGC	0.642000													28	54					0	0	1	0	0	
CEACAM8	1088	broad.mit.edu	37	19	43093151	43093151	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:43093151T>A	uc002oud.2	-	4	845	c.743A>T	c.(742-744)TAT>TTT	p.Y248F	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	248	Ig-like C2-type 2.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				TGCATGGTAATAGGTGTCTGA	0.502000													33	43					0	0	1	0	0	
IRGC	56269	broad.mit.edu	37	19	44223371	44223371	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:44223371G>A	uc002oxh.2	+	2	808	c.661G>A	c.(661-663)GCC>ACC	p.A221T		NM_019612	NP_062558	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	221						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			ovary(1)|central_nervous_system(1)|skin(1)	3		Prostate(69;0.0435)				CCTCTCGCCGGCCCGCTACGA	0.701000													19	17					0	0	1	0	0	
CLPTM1	1209	broad.mit.edu	37	19	45477826	45477826	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:45477826A>G	uc002pai.2	+	4	455	c.440A>G	c.(439-441)GAG>GGG	p.E147G	CLPTM1_uc010ejv.1_Missense_Mutation_p.E45G|CLPTM1_uc010xxf.1_Missense_Mutation_p.E45G|CLPTM1_uc010xxg.1_Missense_Mutation_p.E133G	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	147	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		GGCTGCTACGAGCACTTTGCT	0.577000													17	39					0	0	1	0	0	
PPP5C	5536	broad.mit.edu	37	19	46887054	46887054	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:46887054A>G	uc002pem.2	+	6	777	c.717A>G	c.(715-717)GTA>GTG	p.V239V	PPP5C_uc010xya.1_Silent_p.V106V|PPP5C_uc002pen.2_Silent_p.V217V|PPP5C_uc010xyb.1_Silent_p.V97V	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	239	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		AGATTACAGTATGTGGGGACA	0.552000													34	68					0	0	1	0	0	
ZC3H4	23211	broad.mit.edu	37	19	47569825	47569825	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:47569825C>T	uc002pga.3	-	15	3738	c.3700G>A	c.(3700-3702)GCC>ACC	p.A1234T	ZC3H4_uc002pgb.1_RNA	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	1234							nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGTGGGGTGGCGGTGGTGGCA	0.716000													7	8					0	0	1	0	0	
DHX34	9704	broad.mit.edu	37	19	47870299	47870299	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:47870299C>T	uc010xyn.1	+	7	1996	c.1655C>T	c.(1654-1656)GCC>GTC	p.A552V	DHX34_uc010elc.1_Missense_Mutation_p.A467V	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	552						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCACCACCAGCCAGCCTGGAA	0.617000													9	35					0	0	1	0	0	
SLC8A2	6543	broad.mit.edu	37	19	47969508	47969508	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:47969508C>T	uc002pgx.2	-	2	431	c.153G>A	c.(151-153)CCG>CCA	p.P51P	SLC8A2_uc010xyq.1_Intron|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Silent_p.P51P	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	51	Extracellular (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GCAGCACCCCCGGCTGGCAGC	0.701000													7	10					0	0	1	0	0	
EHD2	30846	broad.mit.edu	37	19	48220237	48220237	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:48220237G>A	uc002phj.3	+	2	618	c.368G>A	c.(367-369)CGC>CAC	p.R123H	EHD2_uc010xyu.1_Intron	NM_014601	NP_055416	Q9NZN4	EHD2_HUMAN	EH-domain containing 2	123					blood coagulation|endocytic recycling	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding			ovary(1)|skin(1)	2		all_cancers(25;6.74e-07)|all_lung(116;2.02e-05)|Lung NSC(112;3.77e-05)|all_epithelial(76;4.89e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		OV - Ovarian serous cystadenocarcinoma(262;0.000336)|all cancers(93;0.000415)|Epithelial(262;0.0132)|GBM - Glioblastoma multiforme(486;0.0537)		AAGCCCTTCCGCAAACTCAAC	0.537000													19	51					0	0	1	0	0	
CCDC114	93233	broad.mit.edu	37	19	48806955	48806955	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:48806955G>T	uc002pir.2	-	8	1512	c.829C>A	c.(829-831)CTG>ATG	p.L277M	CCDC114_uc002piq.2_Missense_Mutation_p.L86M|CCDC114_uc002pio.2_Missense_Mutation_p.L314M|CCDC114_uc002pis.1_5'Flank|CCDC114_uc002pit.1_Missense_Mutation_p.L314M|CCDC114_uc002piu.1_Missense_Mutation_p.L314M	NM_144577	NP_653178	Q96M63	CC114_HUMAN	coiled-coil domain containing 114 isoform 2	277										ovary(1)	1		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		TCCCCCATCAGCTGGGACAGT	0.652000													42	73					4.07013e-28	4.39788e-28	1	1	0	
GRIN2D	2906	broad.mit.edu	37	19	48946554	48946554	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:48946554C>T	uc002pjc.3	+	13	3459	c.3371C>T	c.(3370-3372)GCG>GTG	p.A1124V	GRIN2D_uc010elx.2_Missense_Mutation_p.A359V|GRWD1_uc002pjd.2_5'Flank	NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	1124	Cytoplasmic (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	CTGGGCGGCGCGTCGCTGGGC	0.592000													6	13					0	0	1	0	0	
GRWD1	83743	broad.mit.edu	37	19	48954443	48954443	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:48954443C>T	uc002pjd.2	+	6	1211	c.978C>T	c.(976-978)GGC>GGT	p.G326G		NM_031485	NP_113673	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	326	WD 3.					nucleolus				ovary(1)	1		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		TGCTCAGTGGCGGGGATGATG	0.637000													19	23					0	0	1	0	0	
FUT2	2524	broad.mit.edu	37	19	49206867	49206867	+	Silent	SNP	C	T	T	rs138643842		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49206867C>T	uc002pke.3	+	2	765	c.654C>T	c.(652-654)GCC>GCT	p.A218A	FUT2_uc010emc.2_Silent_p.A218A	NM_001097638	NP_001091107	Q10981	FUT2_HUMAN	fucosyltransferase 2	218	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			central_nervous_system(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		GGGTGGTGGCCGACCGGCGAT	0.617000													11	119					0	0	1	0	0	
IZUMO1	284359	broad.mit.edu	37	19	49247735	49247735	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49247735G>T	uc002pkj.2	-	4	920	c.372C>A	c.(370-372)ACC>ACA	p.T124T	IZUMO1_uc010eme.2_RNA|IZUMO1_uc010emf.2_RNA	NM_182575	NP_872381	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1 precursor	124	Extracellular (Potential).				fusion of sperm to egg plasma membrane	integral to membrane				ovary(1)	1		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		GAGCAACATAGGTGGCAAAGG	0.517000													26	52					7.38237e-10	7.6895e-10	1	1	0	
FUT1	2523	broad.mit.edu	37	19	49254455	49254455	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49254455A>G	uc002pkk.2	-	4	1059	c.84T>C	c.(82-84)CAT>CAC	p.H28H		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	28	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		AGCTGTCTTGATGGATATGGA	0.592000													13	36					0	0	1	0	0	
PPFIA3	8541	broad.mit.edu	37	19	49637338	49637338	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49637338C>T	uc002pmr.2	+	11	1625	c.1293C>T	c.(1291-1293)TCC>TCT	p.S431S	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010emt.2_Silent_p.S355S|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Silent_p.S299S	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	431	Potential.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		AGCGGCTGTCCGAGACGGTGG	0.637000													37	55					0	0	1	0	0	
HRC	3270	broad.mit.edu	37	19	49656860	49656860	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49656860C>T	uc002pmv.2	-	1	1822	c.1635G>A	c.(1633-1635)GAG>GAA	p.E545E		NM_002152	NP_002143	P23327	SRCH_HUMAN	histidine rich calcium binding protein	545					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			ovary(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		cgtcttcttcctcctcctcct	0.333000													7	7					0	0	1	0	0	
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49926533G>C	uc002pnn.1	-	1	166	c.64C>G	c.(64-66)CTG>GTG	p.L22V		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	22					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.597000													15	17					0	0	1	0	0	
PRR12	57479	broad.mit.edu	37	19	50128756	50128756	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:50128756G>A	uc002poo.3	+	14	6003	c.6003G>A	c.(6001-6003)CAG>CAA	p.Q2001Q		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	1180							DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		ACCTGGGCCAGGAGGAGGTGG	0.677000													9	14					0	0	1	0	0	
SCAF1	58506	broad.mit.edu	37	19	50155638	50155638	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:50155638G>A	uc002poq.2	+	7	2116	c.1992G>A	c.(1990-1992)GCG>GCA	p.A664A		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	664	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		Aggccccggcgcccgccccgc	0.607000													5	7					0	0	1	0	0	
SCAF1	58506	broad.mit.edu	37	19	50155754	50155754	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:50155754G>A	uc002poq.2	+	7	2232	c.2108G>A	c.(2107-2109)CGG>CAG	p.R703Q		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	703	Ser-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		GCCATCAAGCGGACCATCACG	0.687000													6	9					0	0	1	0	0	
C19orf41	126123	broad.mit.edu	37	19	50666366	50666366	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:50666366A>G	uc002prp.1	-	1	173	c.86T>C	c.(85-87)CTG>CCG	p.L29P		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	29	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		CAGGGCCTCCAGCACCAAGGG	0.711000													9	12					0	0	1	0	0	
MYH14	79784	broad.mit.edu	37	19	50735200	50735200	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:50735200C>T	uc002prr.1	+	9	1010	c.963C>T	c.(961-963)CTC>CTT	p.L321L	MYH14_uc010enu.1_Silent_p.L329L|MYH14_uc002prq.1_Silent_p.L329L	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	321	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		ACCTCCTCCTCGAGCCCTGCT	0.627000													20	30					0	0	1	0	0	
KCNC3	3748	broad.mit.edu	37	19	50826646	50826646	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:50826646G>T	uc002pru.1	-	2	1859	c.1564C>A	c.(1564-1566)CTG>ATG	p.L522M	KCNC3_uc002prt.1_Missense_Mutation_p.L158M	NM_004977	NP_004968	Q14003	KCNC3_HUMAN	Shaw-related voltage-gated potassium channel	522	Helical; Name=Segment S6; (Potential).				cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			pancreas(1)	1		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		AGGGCACACAGCGCCCCGACC	0.602000													24	41					3.01185e-09	3.1308e-09	1	1	0	
MYBPC2	4606	broad.mit.edu	37	19	50939882	50939882	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:50939882C>A	uc002psf.2	+	5	405	c.354C>A	c.(352-354)ACC>ACA	p.T118T		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	118	Ig-like C2-type 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		AGGTGTACACCGTGGAGCTGC	0.597000													22	49					1.10923e-09	1.15479e-09	1	1	0	
SHANK1	50944	broad.mit.edu	37	19	51217127	51217127	+	Silent	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:51217127A>T	uc002psx.1	-	5	739	c.720T>A	c.(718-720)ATT>ATA	p.I240I		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	240	ANK 1.				cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CCCGGAAGTCAATGTGGGCCC	0.667000													10	51					0	0	1	0	0	
KLK10	5655	broad.mit.edu	37	19	51520463	51520463	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:51520463G>A	uc002puy.2	-	3	253	c.172C>T	c.(172-174)CCC>TCC	p.P58S	KLK10_uc002puz.2_Missense_Mutation_p.P58S|KLK10_uc002pva.2_Missense_Mutation_p.P58S	NM_145888	NP_665895	O43240	KLK10_HUMAN	kallikrein-related peptidase 10 preproprotein	58	Peptidase S1.				cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			lung(2)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		ACCTGCCAGGGCTGCGAGCCG	0.672000											OREG0025646	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	7					0	0	1	0	0	
ZNF836	162962	broad.mit.edu	37	19	52658574	52658574	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:52658574G>A	uc010ydi.1	-	5	2736	c.2362C>T	c.(2362-2364)CGT>TGT	p.R788C	ZNF836_uc010ydj.1_Missense_Mutation_p.R788C	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	788	C2H2-type 21.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GATTGATGACGAAAGACCTTG	0.433000													36	56					0	0	1	0	0	
PPP2R1A	5518	broad.mit.edu	37	19	52723442	52723442	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:52723442G>A	uc002pyp.2	+	11	1462	c.1303G>A	c.(1303-1305)GGA>AGA	p.G435R	PPP2R1A_uc010ydk.1_Missense_Mutation_p.G380R|PPP2R1A_uc002pyq.2_Missense_Mutation_p.G256R	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	435	HEAT 11.|PP2A subunit C binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		TCTCCTGTAGGGAGTGGAGTT	0.522000			Mis		clear cell ovarian carcinoma								5	110					0	0	1	0	0	
ZNF480	147657	broad.mit.edu	37	19	52817449	52817449	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:52817449C>T	uc010ydl.1	+	3	186	c.116C>T	c.(115-117)GCG>GTG	p.A39V	ZNF480_uc002pyv.2_Intron|ZNF480_uc010ydm.1_Missense_Mutation_p.A39V|ZNF480_uc010epn.2_Intron|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		TTCTCTCAGGCGGAGTGGAAA	0.473000													59	105					0	0	1	0	0	
ZNF816A	125893	broad.mit.edu	37	19	53453156	53453156	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:53453156A>G	uc002qal.1	-	5	2173	c.1872T>C	c.(1870-1872)AAT>AAC	p.N624N	ZNF321_uc010eqj.2_Intron|ZNF321_uc002qak.1_Intron|ZNF816A_uc002qam.1_Silent_p.N608N	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	624	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		TGCCACACTCATTACACTTGT	0.383000													63	100					0	0	1	0	0	
NLRP12	91662	broad.mit.edu	37	19	54301519	54301519	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:54301519C>T	uc002qch.3	-	8	3125	c.2905G>A	c.(2905-2907)GCC>ACC	p.A969T	NLRP12_uc010eqw.2_Intron|NLRP12_uc002qci.3_Intron|NLRP12_uc002qcj.3_Missense_Mutation_p.A970T|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	969					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGTCTGCAGGCGGGATGTTGC	0.587000													22	35					0	0	1	0	0	
LILRA6	79168	broad.mit.edu	37	19	54742958	54742958	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:54742958G>A	uc002qeu.1	-	8	1441	c.1317C>T	c.(1315-1317)CAC>CAT	p.H439H	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Silent_p.H283H	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	439	Extracellular (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AATCCTTGGCGTGTGAGGCTG	0.597000													19	68					0	0	1	0	0	
LILRA3	11026	broad.mit.edu	37	19	54803262	54803262	+	Missense_Mutation	SNP	C	A	A	rs150090129	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:54803262C>A	uc002qfd.2	-	4	480	c.415G>T	c.(415-417)GGG>TGG	p.G139W	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Missense_Mutation_p.G139W	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	139	Ig-like C2-type 2.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GTCACATTCCCTCCTGAGGTC	0.542000													7	133					0.000157383	0.000159875	1	1	0	
LILRA1	11024	broad.mit.edu	37	19	55106616	55106616	+	Missense_Mutation	SNP	C	T	T	rs138781448	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:55106616C>T	uc002qgh.1	+	5	592	c.410C>T	c.(409-411)TCA>TTA	p.S137L	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.S137L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	137	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		GTGGTGACCTCAGGAGGGAAC	0.532000													6	110					0	0	1	0	0	
NLRP2	55655	broad.mit.edu	37	19	55481624	55481624	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:55481624C>T	uc002qij.2	+	2	327	c.241C>T	c.(241-243)CGA>TGA	p.R81*	NLRP2_uc010yfp.1_Nonsense_Mutation_p.R58*|NLRP2_uc010esn.2_Nonsense_Mutation_p.R81*|NLRP2_uc010eso.2_Nonsense_Mutation_p.R81*|NLRP2_uc010esp.2_Nonsense_Mutation_p.R81*	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	81	DAPIN.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AAAGATGCACCGAATGGATCT	0.522000													23	40					0	0	1	0	0	
PTPRH	5794	broad.mit.edu	37	19	55693262	55693262	+	Missense_Mutation	SNP	C	T	T	rs140496718		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:55693262C>T	uc002qjq.2	-	20	3281	c.3208G>A	c.(3208-3210)GTA>ATA	p.V1070I	PTPRH_uc010esv.2_Missense_Mutation_p.V892I|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1070	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TGCAGGAATACGTACTGAGCC	0.622000													47	63					0	0	1	0	0	
PTPRH	5794	broad.mit.edu	37	19	55696967	55696967	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:55696967C>T	uc002qjq.2	-	18	3038	c.2965G>A	c.(2965-2967)GTT>ATT	p.V989I	PTPRH_uc010esv.2_Missense_Mutation_p.V811I	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	989	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GAGGAGGGAACGCCGTGATCC	0.607000													13	21					0	0	1	0	0	
FIZ1	84922	broad.mit.edu	37	19	56104134	56104134	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:56104134G>A	uc002qli.3	-	3	1263	c.1173C>T	c.(1171-1173)ACC>ACT	p.T391T	FIZ1_uc002qlj.3_Silent_p.T391T	NM_032836	NP_116225	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CCCGGGCGGCGGTCGCCGCCT	0.741000													14	22					0	0	1	0	0	
NLRP4	147945	broad.mit.edu	37	19	56390204	56390204	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:56390204C>T	uc002qmd.3	+	9	3163	c.2741C>T	c.(2740-2742)GCG>GTG	p.A914V	NLRP4_uc002qmf.2_Missense_Mutation_p.A839V|NLRP4_uc010etf.2_Missense_Mutation_p.A689V	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	914							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AAGGATCTCGCGTCTGTTCTC	0.542000													12	18					0	0	1	0	0	
ZNF444	55311	broad.mit.edu	37	19	56671150	56671150	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:56671150C>A	uc002qmm.2	+	5	931	c.564C>A	c.(562-564)TCC>TCA	p.S188S	ZNF444_uc002qmn.1_Silent_p.S187S	NM_018337	NP_060807	Q8N0Y2	ZN444_HUMAN	zinc finger protein 444	188	C2H2-type 1.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0531)		GCAAAACGTCCCTGAAACCAG	0.716000													4	4					0.217242	0.21756	1	1	0	
ZNF256	10172	broad.mit.edu	37	19	58452730	58452730	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:58452730C>A	uc002qqu.2	-	3	1681	c.1446G>T	c.(1444-1446)TGG>TGT	p.W482C	ZNF256_uc010euj.2_Missense_Mutation_p.W329C	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	482	C2H2-type 10.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		TATGAACTTTCCAGTGTGAGA	0.448000													30	38					1.39806e-14	1.48025e-14	1	1	0	
ZNF497	162968	broad.mit.edu	37	19	58867745	58867745	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:58867745G>A	uc002qsh.1	-	3	1446	c.1257C>T	c.(1255-1257)TGC>TGT	p.C419C	A1BG_uc002qsd.3_5'Flank|A1BG_uc002qsf.1_Intron|ZNF497_uc002qsi.1_Silent_p.C419C|uc002qsj.1_5'Flank|uc002qsk.1_5'Flank	NM_198458	NP_940860	Q6ZNH5	ZN497_HUMAN	zinc finger protein 497	419	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0278)		AGGCCTTGCCGCATTCTGCGC	0.711000													3	6					0	0	1	0	0	
ZNF324	25799	broad.mit.edu	37	19	58982407	58982407	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:58982407C>T	uc002qsw.1	+	4	642	c.548C>T	c.(547-549)GCG>GTG	p.A183V	ZNF324_uc002qsx.1_5'UTR	NM_014347	NP_055162	O75467	Z324A_HUMAN	zinc finger protein 324	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		ACAGAGCATGCGTTGCTGGGG	0.657000													21	20					0	0	1	0	0	
FAM110C	642273	broad.mit.edu	37	2	45589	45589	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:45589C>T	uc010yim.1	-	1	797	c.797G>A	c.(796-798)GGC>GAC	p.G266D		NM_001077710	NP_001071178	Q1W6H9	F110C_HUMAN	hypothetical protein LOC642273	266						microtubule|microtubule organizing center|spindle pole					0	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00221)		all cancers(51;0.000815)|Epithelial(75;0.00379)|OV - Ovarian serous cystadenocarcinoma(76;0.0127)|GBM - Glioblastoma multiforme(21;0.232)		CTCGTCGTCGCCGCCGCTGTG	0.667000													13	18					0	0	1	0	0	
PXDN	7837	broad.mit.edu	37	2	1652064	1652064	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:1652064C>T	uc002qxa.2	-	17	3552	c.3488G>A	c.(3487-3489)CGG>CAG	p.R1163Q		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1163					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CCCGTGGTCCCGGCCCCGCTG	0.602000													39	74					0	0	1	0	0	
MYT1L	23040	broad.mit.edu	37	2	1796190	1796190	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:1796190T>C	uc002qxe.2	-	24	4150	c.3323A>G	c.(3322-3324)AAA>AGA	p.K1108R	MYT1L_uc002qxd.2_Missense_Mutation_p.K1106R|MYT1L_uc010ewk.2_Missense_Mutation_p.K106R	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	1108	Potential.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTCAATCACTTTGTTCTCCTC	0.542000													7	19					0	0	1	0	0	
RPS7	6201	broad.mit.edu	37	2	3628430	3628430	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:3628430G>A	uc002qxw.2	+	7	649	c.543G>A	c.(541-543)ACG>ACA	p.T181T	RPS7_uc002qxy.2_RNA	NM_001011	NP_001002	P62081	RS7_HUMAN	ribosomal protein S7	181					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		AGAAGCTCACGGGCAAGGATG	0.303000													16	23					0	0	1	0	0	
COLEC11	78989	broad.mit.edu	37	2	3691383	3691383	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:3691383C>T	uc002qya.2	+	7	639	c.491C>T	c.(490-492)GCG>GTG	p.A164V	COLEC11_uc002qxz.2_Missense_Mutation_p.A161V|COLEC11_uc002qyb.2_Missense_Mutation_p.A140V|COLEC11_uc002qyc.2_Missense_Mutation_p.A140V|COLEC11_uc010ewo.2_Missense_Mutation_p.A116V|COLEC11_uc010ewp.2_Missense_Mutation_p.A138V|COLEC11_uc010ewq.2_Missense_Mutation_p.A114V|COLEC11_uc010ewr.2_Missense_Mutation_p.A114V|COLEC11_uc010ews.2_Missense_Mutation_p.A90V	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	164	C-type lectin.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		AAGCGCTACGCGGACGCCCAG	0.657000													26	44					0	0	1	0	0	
ROCK2	9475	broad.mit.edu	37	2	11359113	11359113	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:11359113G>T	uc002rbd.1	-	10	1748	c.1299C>A	c.(1297-1299)TCC>TCA	p.S433S		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	433	Potential.|Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TTGATTGTATGGAATCAGTTT	0.284000													18	24					2.21704e-12	2.33175e-12	1	1	0	
DDX1	1653	broad.mit.edu	37	2	15760382	15760382	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:15760382C>T	uc002rce.2	+	17	1545	c.1257C>T	c.(1255-1257)TCC>TCT	p.S419S	DDX1_uc010yjq.1_Silent_p.S327S	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	419	Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		AGAAACTGTCCGAGAAGATAA	0.368000													30	65					0	0	1	0	0	
SMC6	79677	broad.mit.edu	37	2	17899380	17899380	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:17899380A>G	uc002rco.2	-	12	1352	c.1056T>C	c.(1054-1056)GAT>GAC	p.D352D	SMC6_uc010exo.2_Silent_p.D352D|SMC6_uc002rcn.2_Silent_p.D352D|SMC6_uc002rcp.1_Silent_p.D378D|SMC6_uc002rcq.2_Silent_p.D378D|SMC6_uc002rcr.1_Silent_p.D352D	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	352	Potential.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TAGCAACAACATCTGCTTTCA	0.363000													43	79					0	0	1	0	0	
KCNS3	3790	broad.mit.edu	37	2	18112465	18112465	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:18112465G>T	uc002rcv.2	+	3	641	c.190G>T	c.(190-192)GAT>TAT	p.D64Y	KCNS3_uc002rcw.2_Missense_Mutation_p.D64Y	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	64	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CAGTGTGGCCGATAAGGAGTA	0.478000													51	61					2.43468e-25	2.62246e-25	1	1	0	
APOB	338	broad.mit.edu	37	2	21232207	21232207	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:21232207T>C	uc002red.2	-	26	7661	c.7533A>G	c.(7531-7533)AAA>AAG	p.K2511K		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2511					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCTCTCGGAATTTGGCCTTCA	0.438000													34	44					0	0	1	0	0	
ASXL2	55252	broad.mit.edu	37	2	26101090	26101090	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:26101090A>G	uc002rgs.2	-	1	223	c.2T>C	c.(1-3)ATG>ACG	p.M1T		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	1					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTTTCCCTCATGTCGGGTCT	0.667000													48	89					0	0	1	0	0	
C2orf53	339779	broad.mit.edu	37	2	27360918	27360918	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:27360918A>G	uc002rjb.2	-	3	860	c.280T>C	c.(280-282)TCC>CCC	p.S94P		NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	94	Pro-rich.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAAGTAGGGGAACTTGGGAGA	0.323000													11	25					0	0	1	0	0	
SNX17	9784	broad.mit.edu	37	2	27597016	27597016	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:27597016G>A	uc002rkg.1	+	6	719	c.497G>A	c.(496-498)CGA>CAA	p.R166Q	SNX17_uc010ylj.1_Missense_Mutation_p.R146Q|SNX17_uc010ylk.1_5'UTR|SNX17_uc010eza.1_5'UTR|SNX17_uc002rki.1_RNA|SNX17_uc002rkh.1_5'UTR|SNX17_uc010yll.1_5'UTR|SNX17_uc010ylm.1_5'UTR|SNX17_uc010yln.1_Missense_Mutation_p.R154Q|SNX17_uc010ylo.1_Missense_Mutation_p.R84Q|SNX17_uc010ylp.1_Missense_Mutation_p.R141Q|SNX17_uc010ylq.1_5'UTR	NM_014748	NP_055563	Q15036	SNX17_HUMAN	sorting nexin 17	166	Ras-associating.				cell communication|endosome transport|intracellular protein transport|regulation of endocytosis|signal transduction	cytoplasmic vesicle membrane|cytosol|early endosome|Golgi apparatus	low-density lipoprotein particle receptor binding|phosphatidylinositol binding|protein C-terminus binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCTTAGTTCGAGAAAAAGAG	0.468000													35	59					0	0	1	0	0	
FOSL2	2355	broad.mit.edu	37	2	28627027	28627027	+	Silent	SNP	C	T	T	rs112541505		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:28627027C>T	uc002rma.2	+	2	965	c.156C>T	c.(154-156)AAC>AAT	p.N52N	FOSL2_uc010ymi.1_Silent_p.N13N	NM_005253	NP_005244	P15408	FOSL2_HUMAN	FOS-like antigen 2	52					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(172;0.155)					CCACCATCAACGCCATCACGA	0.527000													10	87					0	0	1	0	0	
EHD3	30845	broad.mit.edu	37	2	31483572	31483572	+	Silent	SNP	C	T	T	rs147844646		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:31483572C>T	uc002rnu.2	+	4	1307	c.699C>T	c.(697-699)TAC>TAT	p.Y233Y	EHD3_uc010ymt.1_Intron	NM_014600	NP_055415	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	233					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					TGCGGGTGTACGGGGCCCTCA	0.577000													38	25					0	0	1	0	0	
MEMO1	51072	broad.mit.edu	37	2	32093439	32093439	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:32093439C>T	uc002rnx.2	-	9	1267	c.885G>A	c.(883-885)ACG>ACA	p.T295T	MEMO1_uc010ymu.1_Silent_p.T272T|MEMO1_uc010ezq.2_Silent_p.T295T|MEMO1_uc002rny.2_RNA|MEMO1_uc002rnz.2_RNA	NM_015955	NP_057039	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1 isoform 1	295					regulation of microtubule-based process	cytosol|nucleus				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					TTCAGTGGACCGTGAGTGCTC	0.493000													7	15					0	0	1	0	0	
NLRC4	58484	broad.mit.edu	37	2	32460605	32460605	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:32460605C>T	uc002roi.2	-	8	2893	c.2647G>A	c.(2647-2649)GCA>ACA	p.A883T	NLRC4_uc002roj.1_Missense_Mutation_p.A883T|NLRC4_uc010ezt.1_Missense_Mutation_p.A218T	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	883	LRR 10.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AGCATCAGTGCGGTGAGCTGT	0.517000													6	78					0	0	1	0	0	
BIRC6	57448	broad.mit.edu	37	2	32626547	32626547	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:32626547A>T	uc010ezu.2	+	8	1408	c.1274A>T	c.(1273-1275)GAA>GTA	p.E425V		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	425					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTAAAGTTTGAAATTAATGCC	0.358000													20	49					0	0	1	0	0	
FAM98A	25940	broad.mit.edu	37	2	33813510	33813510	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:33813510G>A	uc002rpa.1	-	4	488	c.414C>T	c.(412-414)GGC>GGT	p.G138G	FAM98A_uc010yne.1_Intron|FAM98A_uc010ynd.1_5'Flank|FAM98A_uc002roz.1_Silent_p.G15G	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	138										ovary(1)	1	all_hematologic(175;0.115)					CCTCACTACCGCCTCCTTCTT	0.418000													43	64					0	0	1	0	0	
CRIM1	51232	broad.mit.edu	37	2	36739444	36739444	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:36739444C>T	uc002rpd.2	+	10	1726	c.1687C>T	c.(1687-1689)CGC>TGC	p.R563C		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	563	Antistasin-like 3.|Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TGACATCTGTCGCTGTAAGAA	0.463000													61	91					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	2	38709137	38709137	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:38709137G>A	uc002rqu.1	+	1	212	c.145G>A	c.(145-147)GGG>AGG	p.G49R						SubName: Full=RPLP0 protein;																		GTCCCTTCGCGGGAAGGTCGT	0.517000													26	34					0	0	1	0	0	
PKDCC	91461	broad.mit.edu	37	2	42282160	42282160	+	Nonsense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:42282160G>T	uc002rsg.2	+	4	1293	c.1114G>T	c.(1114-1116)GGA>TGA	p.G372*		NM_138370	NP_612379	Q504Y2	PKDCC_HUMAN	protein kinase-like protein SgK493	372	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(1)	1						CAACGCCACAGGTGAGCTCTC	0.592000													33	75					1.74807e-11	1.8357e-11	1	1	0	
MTA3	57504	broad.mit.edu	37	2	42909709	42909709	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:42909709A>G	uc002rso.1	+	10	1373	c.703A>G	c.(703-705)AAT>GAT	p.N235D	MTA3_uc002rsp.1_Missense_Mutation_p.N235D|MTA3_uc002rsq.2_Missense_Mutation_p.N291D|MTA3_uc002rsr.2_Missense_Mutation_p.N291D	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	291	SANT.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						CAAAGACTTCAATGACATACG	0.358000													10	5					0	0	1	0	0	
PRKCE	5581	broad.mit.edu	37	2	46313362	46313362	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:46313362G>A	uc002rut.2	+	11	1650	c.1453G>A	c.(1453-1455)GTC>ATC	p.V485I		NM_005400	NP_005391	Q02156	KPCE_HUMAN	protein kinase C, epsilon	485	Protein kinase.				activation of phospholipase C activity|induction of apoptosis|intracellular signal transduction|nerve growth factor receptor signaling pathway|platelet activation	cytosol|endoplasmic reticulum|plasma membrane	ATP binding|enzyme activator activity|metal ion binding|signal transducer activity			lung(4)|ovary(3)|kidney(1)|breast(1)|large_intestine(1)	10		all_hematologic(82;0.155)|Acute lymphoblastic leukemia(82;0.209)	LUSC - Lung squamous cell carcinoma(58;0.171)			CCTCTTTTTCGTCATGGAATA	0.488000													44	79					0	0	1	0	0	
EPAS1	2034	broad.mit.edu	37	2	46605204	46605204	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:46605204G>C	uc002ruv.2	+	10	1909	c.1421G>C	c.(1420-1422)AGC>ACC	p.S474T	EPAS1_uc002ruw.2_5'Flank	NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	474	Poly-Ser.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			AGTGCCACCAGCAGCAGCAGC	0.647000													8	1					0	0	1	0	0	
TSPYL6	388951	broad.mit.edu	37	2	54482354	54482354	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:54482354A>G	uc002rxr.2	-	1	1056	c.935T>C	c.(934-936)GTG>GCG	p.V312A	ACYP2_uc002rxq.3_Intron	NM_001003937	NP_001003937	Q8N831	TSYL6_HUMAN	TSPY-like 6	312					nucleosome assembly	nucleus					0						GACCTCATACACCTTTACAAT	0.468000													43	58					0	0	1	0	0	
BCL11A	53335	broad.mit.edu	37	2	60688652	60688652	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:60688652G>T	uc002sae.1	-	4	1623	c.1395C>A	c.(1393-1395)TCC>TCA	p.S465S	BCL11A_uc002sab.2_Silent_p.S465S|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Silent_p.S134S|BCL11A_uc010ypj.1_Silent_p.S431S|BCL11A_uc002sad.1_Silent_p.S313S|BCL11A_uc002saf.1_Silent_p.S431S	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	465					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGGCCACCACGGACTTGAGCG	0.483000			T	IGH@	B-CLL								15	22					2.31682e-05	2.35817e-05	1	1	0	
BCL11A	53335	broad.mit.edu	37	2	60688858	60688858	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:60688858G>A	uc002sae.1	-	4	1417	c.1189C>T	c.(1189-1191)CGC>TGC	p.R397C	BCL11A_uc002sab.2_Missense_Mutation_p.R397C|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.R66C|BCL11A_uc010ypj.1_Missense_Mutation_p.R363C|BCL11A_uc002sad.1_Missense_Mutation_p.R245C|BCL11A_uc002saf.1_Missense_Mutation_p.R363C	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	397	C2H2-type 2.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GTGTGGCTGCGCCGGTGCACC	0.617000			T	IGH@	B-CLL								54	84					0	0	1	0	0	
USP34	9736	broad.mit.edu	37	2	61552563	61552563	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:61552563C>T	uc002sbe.2	-	21	2982	c.2960G>A	c.(2959-2961)CGT>CAT	p.R987H		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	987					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GAATTGAAGACGAACTTGAAC	0.279000													11	33					0	0	1	0	0	
UGP2	7360	broad.mit.edu	37	2	64085069	64085069	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:64085069C>T	uc002scm.2	+	3	560	c.254C>T	c.(253-255)TCG>TTG	p.S85L	UGP2_uc002scl.2_Missense_Mutation_p.S74L|UGP2_uc010ypx.1_Missense_Mutation_p.S94L	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	85					glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						CCTGAAGATTCGGTAAGTTTT	0.408000													44	89					0	0	1	0	0	
MEIS1	4211	broad.mit.edu	37	2	66667042	66667042	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:66667042G>A	uc002sdu.2	+	3	764	c.307G>A	c.(307-309)GAG>AAG	p.E103K	MEIS1_uc002sdt.2_Missense_Mutation_p.E103K|MEIS1_uc002sdv.2_Missense_Mutation_p.E101K|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Missense_Mutation_p.E38K|MEIS1_uc002sdw.1_5'Flank	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	103							sequence-specific DNA binding transcription factor activity				0						TACCCCCCGCGAGCCGGGGGT	0.473000													6	13					0	0	1	0	0	
MEIS1	4211	broad.mit.edu	37	2	66775109	66775109	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:66775109T>C	uc002sdu.2	+	9	1380	c.923T>C	c.(922-924)TTG>TCG	p.L308S	MEIS1_uc002sdt.2_Missense_Mutation_p.L308S|MEIS1_uc002sdv.2_Missense_Mutation_p.L306S|MEIS1_uc010yqh.1_RNA|MEIS1_uc010yqi.1_Missense_Mutation_p.L243S|MEIS1_uc002sdw.1_Missense_Mutation_p.L164S	NM_002398	NP_002389	O00470	MEIS1_HUMAN	Meis homeobox 1	308	Homeobox; TALE-type.						sequence-specific DNA binding transcription factor activity				0						AAAAAGCAGTTGGCACAAGAC	0.423000													18	52					0	0	1	0	0	
GMCL1	64395	broad.mit.edu	37	2	70096881	70096881	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:70096881G>A	uc002sfu.2	+	12	1456	c.1249G>A	c.(1249-1251)GGC>AGC	p.G417S		NM_178439	NP_848526	Q96IK5	GMCL1_HUMAN	germ cell-less	417					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				ovary(3)	3						TTTTAACTTCGGCTTCGACCT	0.363000													35	53					0	0	1	0	0	
MXD1	4084	broad.mit.edu	37	2	70164383	70164383	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:70164383A>G	uc002sfy.2	+	5	595	c.335A>G	c.(334-336)GAC>GGC	p.D112G	MXD1_uc010yqp.1_Missense_Mutation_p.D112G|MXD1_uc010yqq.1_Missense_Mutation_p.D49G|MXD1_uc010yqr.1_RNA|MXD1_uc010yqs.1_Missense_Mutation_p.D102G	NM_002357	NP_002348	Q05195	MAD1_HUMAN	MAX dimerization protein 1	112					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0						GAAGATTGTGACAGAAAAGCC	0.542000													66	76					0	0	1	0	0	
TIA1	7072	broad.mit.edu	37	2	70454867	70454867	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:70454867G>A	uc002sgj.3	-	6	615	c.398C>T	c.(397-399)TCA>TTA	p.S133L	TIA1_uc002sgk.3_Missense_Mutation_p.S122L|TIA1_uc002sgl.3_RNA|TIA1_uc002sgm.3_Missense_Mutation_p.S133L	NM_022173	NP_071505	P31483	TIA1_HUMAN	TIA1 cytotoxic granule-associated RNA binding	133	RRM 2.				apoptosis|induction of apoptosis|regulation of nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|poly(A) RNA binding|protein binding				0						TGTTACTTACGATATTCTTCC	0.284000													31	56					0	0	1	0	0	
ZNF638	27332	broad.mit.edu	37	2	71658542	71658542	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:71658542G>A	uc002shx.2	+	26	6055	c.5736G>A	c.(5734-5736)GCG>GCA	p.A1912A	ZNF638_uc002shy.2_Silent_p.A1912A|ZNF638_uc002shz.2_Silent_p.A1912A|ZNF638_uc002sia.2_Silent_p.A1912A|ZNF638_uc010fed.2_RNA|ZNF638_uc002sic.2_Silent_p.A1009A|ZNF638_uc002sid.2_Silent_p.A281A	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1912					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						AATCAGTGGCGTCTGATGTCC	0.308000													23	36					0	0	1	0	0	
DYSF	8291	broad.mit.edu	37	2	71801427	71801427	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:71801427C>T	uc002sie.2	+	30	3650	c.3274C>T	c.(3274-3276)CGC>TGC	p.R1092C	DYSF_uc010feg.2_Missense_Mutation_p.R1123C|DYSF_uc010feh.2_Missense_Mutation_p.R1078C|DYSF_uc002sig.3_Missense_Mutation_p.R1078C|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R1092C|DYSF_uc010fef.2_Missense_Mutation_p.R1109C|DYSF_uc010fei.2_Missense_Mutation_p.R1109C|DYSF_uc010fek.2_Missense_Mutation_p.R1110C|DYSF_uc010fej.2_Missense_Mutation_p.R1079C|DYSF_uc010fel.2_Missense_Mutation_p.R1079C|DYSF_uc010feo.2_Missense_Mutation_p.R1124C|DYSF_uc010fem.2_Missense_Mutation_p.R1093C|DYSF_uc010fen.2_Missense_Mutation_p.R1110C|DYSF_uc002sif.2_Missense_Mutation_p.R1093C|DYSF_uc010yqy.1_5'Flank	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1092	Cytoplasmic (Potential).|Arg-rich.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTTCCGCCGCCGCCGCTGGCG	0.667000													67	91					0	0	1	0	0	
TET3	200424	broad.mit.edu	37	2	74274599	74274599	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:74274599G>A	uc002skb.3	+	1	1150	c.1150G>A	c.(1150-1152)GAC>AAC	p.D384N	TET3_uc010fez.1_Missense_Mutation_p.D384N	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	384							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTCGGAGCCCGACACCCACCA	0.657000													15	17					0	0	1	0	0	
TET3	200424	broad.mit.edu	37	2	74328868	74328868	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:74328868C>T	uc002skb.3	+	9	4548	c.4548C>T	c.(4546-4548)ATC>ATT	p.I1516I		NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	1516							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						ACGAGAACATCGGCGGCGTGG	0.667000													31	50					0	0	1	0	0	
SLC4A5	57835	broad.mit.edu	37	2	74491388	74491388	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:74491388G>A	uc002sko.1	-	5	603	c.601C>T	c.(601-603)CGG>TGG	p.R201W	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.R201W|SLC4A5_uc010ffc.1_Missense_Mutation_p.R201W|SLC4A5_uc002skp.1_Missense_Mutation_p.R137W|SLC4A5_uc002sks.1_Missense_Mutation_p.R201W	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	201	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						AGCTCTGGCCGCAGGAGACCA	0.552000													38	37					0	0	1	0	0	
DCTN1	1639	broad.mit.edu	37	2	74589792	74589792	+	Silent	SNP	G	A	A	rs115689748	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:74589792G>A	uc002skx.2	-	30	3905	c.3594C>T	c.(3592-3594)ACC>ACT	p.T1198T	SLC4A5_uc002skl.2_RNA|DCTN1_uc002skt.1_Silent_p.T132T|DCTN1_uc002skv.2_Silent_p.T1064T|DCTN1_uc002sku.2_Silent_p.T1059T|DCTN1_uc002skw.1_Silent_p.T1174T|DCTN1_uc010ffd.2_Silent_p.T1173T|DCTN1_uc002sky.2_Silent_p.T1156T	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	1198	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GCTTCTCGACGGTGTCACTCA	0.542000													12	18					0	0	1	0	0	
LRRTM4	80059	broad.mit.edu	37	2	77745718	77745718	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:77745718A>G	uc002snr.2	-	3	1692	c.1277T>C	c.(1276-1278)ATT>ACT	p.I426T	LRRTM4_uc002snq.2_Missense_Mutation_p.I426T|LRRTM4_uc002sns.2_Missense_Mutation_p.I426T|LRRTM4_uc002snt.2_Missense_Mutation_p.I427T	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	426	Helical; (Potential).					integral to membrane		p.I426F(1)		pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		ACTCCCGGCAATAATTTTGTG	0.493000													24	47					0	0	1	0	0	
C2orf89	129293	broad.mit.edu	37	2	85108085	85108085	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:85108085C>T	uc010ysl.1	-	1	168	c.79G>A	c.(79-81)GGC>AGC	p.G27S	C2orf89_uc002sou.3_Missense_Mutation_p.G27S|C2orf89_uc010fgc.1_Missense_Mutation_p.G27S	NM_001080824	NP_001074293	Q86V40	CB089_HUMAN	hypothetical protein LOC129293 precursor	27	Extracellular (Potential).					integral to membrane				ovary(1)	1						TTGGCGGTGCCGGGCGCCCCG	0.701000													8	7					0	0	1	0	0	
VAMP5	10791	broad.mit.edu	37	2	85818963	85818963	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:85818963G>A	uc002spu.1	+	2	202	c.119G>A	c.(118-120)CGT>CAT	p.R40H		NM_006634	NP_006625	O95183	VAMP5_HUMAN	vesicle-associated membrane protein 5	40	v-SNARE coiled-coil homology.|Cytoplasmic (Potential).				cell differentiation|vesicle-mediated transport	endomembrane system					0						CTGCAGCAGCGTTCAGACCAA	0.582000													55	66					0	0	1	0	0	
SFTPB	6439	broad.mit.edu	37	2	85892896	85892896	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:85892896G>A	uc002sqh.2	-	5	421	c.415C>T	c.(415-417)CAC>TAC	p.H139Y	SFTPB_uc002sqi.2_Missense_Mutation_p.H151Y|SFTPB_uc002sqj.2_Missense_Mutation_p.H139Y	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	139	Saposin B-type 1.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						AGGCCCAGGTGCATACAGATG	0.647000													30	47					0	0	1	0	0	
KDM3A	55818	broad.mit.edu	37	2	86676934	86676934	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:86676934G>A	uc002sri.3	+	3	518	c.191G>A	c.(190-192)TGT>TAT	p.C64Y	KDM3A_uc010ytj.1_Missense_Mutation_p.C64Y|KDM3A_uc010ytk.1_Intron	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	64					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						GTCTAGGTGTGTGTGGAATTT	0.378000													27	56					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	2	89111172	89111172	+	RNA	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:89111172T>C	uc002sth.1	-	2		c.195A>G								full-length cDNA clone CS0DL003YK18 of B cells (Ramos cell line) Cot 25-normalized of Homo sapiens (human).																		GCTGAAGGCATGGAGAATGTA	0.527000													10	23					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	2	89292225	89292225	+	Splice_Site	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:89292225T>C	uc010ytr.1	-	82		c.6983_splice	c.e82-1		uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		ATCTGGCACCTGAGATTGGAA	0.473000													50	87					0	0	1	0	0	
REV1	51455	broad.mit.edu	37	2	100058920	100058920	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:100058920C>T	uc002tad.2	-	5	574	c.362G>A	c.(361-363)GGA>GAA	p.G121E	REV1_uc002tac.2_Missense_Mutation_p.G121E|REV1_uc002tae.1_Missense_Mutation_p.G100E	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	121	BRCT.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						GAGGAGTCGTCCAGCTTTGAT	0.418000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					26	41					0	0	1	0	0	
AFF3	3899	broad.mit.edu	37	2	100266104	100266104	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:100266104G>A	uc002tag.2	-	12	1404	c.1168C>T	c.(1168-1170)CGC>TGC	p.R390C	AFF3_uc002taf.2_Missense_Mutation_p.R415C|AFF3_uc010fiq.1_Missense_Mutation_p.R390C|AFF3_uc010yvr.1_Missense_Mutation_p.R543C|AFF3_uc002tah.1_Missense_Mutation_p.R415C	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	390					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GAGAGAGCGCGGAGAGCCGTT	0.363000													44	60					0	0	1	0	0	
PDCL3	79031	broad.mit.edu	37	2	101192912	101192912	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:101192912G>A	uc002tao.2	+	6	786	c.674G>A	c.(673-675)CGG>CAG	p.R225Q		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	225					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0						TCCTCAGTGCGGCGCTCTGTC	0.478000													24	28					0	0	1	0	0	
RNF149	284996	broad.mit.edu	37	2	101924991	101924991	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:101924991C>T	uc002taz.1	-	1	162	c.60G>A	c.(58-60)TTG>TTA	p.L20L	RNF149_uc002tax.1_RNA	NM_173647	NP_775918	Q8NC42	RN149_HUMAN	ring finger protein 149 precursor	20						integral to membrane	ligase activity|zinc ion binding			ovary(1)|breast(1)	2						CCAGGGCGAGCAACGCCAGAG	0.607000													10	10					0	0	1	0	0	
IL1R2	7850	broad.mit.edu	37	2	102641036	102641036	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:102641036G>A	uc002tbm.2	+	7	1022	c.793G>A	c.(793-795)GGC>AGC	p.G265S	IL1R2_uc002tbn.2_Missense_Mutation_p.G265S|IL1R2_uc002tbo.1_Missense_Mutation_p.G265S	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	265	Extracellular (Potential).|Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	TCTGGGAACCGGCACACCCTT	0.607000													15	32					0	0	1	0	0	
RGPD4	285190	broad.mit.edu	37	2	108489198	108489198	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:108489198A>C	uc010ywk.1	+	20	4820	c.4738A>C	c.(4738-4740)AGT>CGT	p.S1580R	RGPD4_uc002tdu.2_Missense_Mutation_p.S767R|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1580					intracellular transport		binding			skin(2)	2						ATCTTTGAAAAGTAACAACAG	0.353000													126	193					0	0	1	0	0	
RANBP2	5903	broad.mit.edu	37	2	109381658	109381658	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:109381658C>T	uc002tem.3	+	20	4789	c.4663C>T	c.(4663-4665)CGA>TGA	p.R1555*		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1555	RanBP2-type 4.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						ATGCTTAGTGCGAAATGAAGC	0.403000													80	121					0	0	1	0	0	
SH3RF3	344558	broad.mit.edu	37	2	110015252	110015252	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:110015252G>A	uc010ywt.1	+	4	1152	c.1152G>A	c.(1150-1152)GCG>GCA	p.A384A		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	384							zinc ion binding			ovary(1)	1						CCTTCACCGCGCTCAGTGTGA	0.597000													12	14					0	0	1	0	0	
TSN	7247	broad.mit.edu	37	2	122514875	122514875	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:122514875G>A	uc002tnl.2	+	2	361	c.126G>A	c.(124-126)CTG>CTA	p.L42L	TSN_uc002tnm.2_5'UTR|TSN_uc010yze.1_Silent_p.L42L|TSN_uc010flt.2_Intron	NM_004622	NP_004613	Q15631	TSN_HUMAN	translin	42					DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding			breast(2)|large_intestine(1)	3		Ovarian(717;0.0563)|Prostate(154;0.116)				TAACTCTACTGCAAGGGGTCC	0.363000													19	43					0	0	1	0	0	
MYO7B	4648	broad.mit.edu	37	2	128394393	128394393	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:128394393A>G	uc002top.2	+	46	6207	c.6154A>G	c.(6154-6156)ACC>GCC	p.T2052A	MYO7B_uc002tos.1_Missense_Mutation_p.T162A|MYO7B_uc002tot.2_Missense_Mutation_p.T162A	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2052	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTATCCCTTCACCAAGATCTC	0.667000													27	19					0	0	1	0	0	
HS6ST1	9394	broad.mit.edu	37	2	129026306	129026306	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:129026306C>T	uc002tpt.3	-	2	700	c.666G>A	c.(664-666)CCG>CCA	p.P222P		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	222	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		CGTAGCAGGGCGGCAGCTCCT	0.662000													30	56					0	0	1	0	0	
LCT	3938	broad.mit.edu	37	2	136547367	136547367	+	Silent	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:136547367A>C	uc002tuu.1	-	16	5348	c.5337T>G	c.(5335-5337)GCT>GCG	p.A1779A		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1779	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		TGTCCTGCACAGCTGCTCAAA	0.522000													22	59					0	0	1	0	0	
GTDC1	79712	broad.mit.edu	37	2	144899478	144899478	+	Nonsense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:144899478G>T	uc002tvp.2	-	6	771	c.492C>A	c.(490-492)TAC>TAA	p.Y164*	GTDC1_uc002tvo.2_Nonsense_Mutation_p.Y164*|GTDC1_uc002tvq.2_Nonsense_Mutation_p.Y164*|GTDC1_uc002tvr.2_Nonsense_Mutation_p.Y164*|GTDC1_uc010fnn.2_Nonsense_Mutation_p.Y164*|GTDC1_uc002tvs.2_Nonsense_Mutation_p.Y132*|GTDC1_uc010fno.2_Nonsense_Mutation_p.Y35*|GTDC1_uc002tvt.1_Nonsense_Mutation_p.Y164*	NM_001006636	NP_001006637	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	164					biosynthetic process		transferase activity, transferring glycosyl groups			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.0914)		TGATGGGAAAGTAAATAACTT	0.373000													27	52					1.50538e-07	1.54915e-07	1	1	0	
GPD2	2820	broad.mit.edu	37	2	157352618	157352618	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:157352618T>C	uc002tzf.3	+	3	525	c.165T>C	c.(163-165)CCT>CCC	p.P55P	GPD2_uc010zch.1_Intron|GPD2_uc002tzd.3_Silent_p.P55P	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	55					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						GGGAGCCTCCTTCCAGAGAAG	0.453000													27	35					0	0	1	0	0	
CCDC148	130940	broad.mit.edu	37	2	159077162	159077162	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:159077162G>A	uc002tzq.2	-	11	1578	c.1315C>T	c.(1315-1317)CGT>TGT	p.R439C	CCDC148_uc002tzr.2_Missense_Mutation_p.R287C|CCDC148_uc010foh.2_Missense_Mutation_p.R152C	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	439										ovary(2)	2						TCTTCTAGACGCTGAAGATCT	0.313000													10	15					0	0	1	0	0	
TANC1	85461	broad.mit.edu	37	2	160080864	160080864	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:160080864G>A	uc002uag.2	+	23	4074	c.3800G>A	c.(3799-3801)GGA>GAA	p.G1267E	TANC1_uc010zcm.1_Missense_Mutation_p.G1259E|TANC1_uc010fom.1_Missense_Mutation_p.G1073E|TANC1_uc010fon.2_Missense_Mutation_p.G111E	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1267	ANK 11.					cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CTCAGAAAGGGAGCCAAGTTA	0.597000													18	30					0	0	1	0	0	
LY75	4065	broad.mit.edu	37	2	160667123	160667123	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:160667123C>T	uc002ubc.3	-	32	4682	c.4613G>A	c.(4612-4614)CGG>CAG	p.R1538Q	LY75_uc002ubb.3_Missense_Mutation_p.R1538Q|LY75_uc010fos.2_Missense_Mutation_p.R1538Q	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1538	Extracellular (Potential).				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		CTGGATCCACCGTGACCCATT	0.393000													66	131					0	0	1	0	0	
DPP4	1803	broad.mit.edu	37	2	162875265	162875265	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:162875265G>A	uc002ubz.2	-	16	1955	c.1394C>T	c.(1393-1395)GCG>GTG	p.A465V	DPP4_uc010fpb.2_Missense_Mutation_p.A141V	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	465	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	ATAATACTTCGCCTCTTTACT	0.473000													26	70					0	0	1	0	0	
TTC21B	79809	broad.mit.edu	37	2	166740436	166740436	+	Silent	SNP	C	T	T	rs148113339	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:166740436C>T	uc002udk.2	-	26	3685	c.3552G>A	c.(3550-3552)GCG>GCA	p.A1184A	TTC21B_uc002udj.1_RNA	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	1184						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						AATTCATTTTCGCAATACGCT	0.423000													29	62					0	0	1	0	0	
SCN1A	6323	broad.mit.edu	37	2	166908335	166908335	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:166908335G>A	uc010zcz.1	-	6	876	c.858C>T	c.(856-858)TCC>TCT	p.S286S	SCN1A_uc002udo.3_Silent_p.S155S|SCN1A_uc010fpk.2_Silent_p.S155S	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	286	I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GTTCCTCCAAGGAAGCATTGG	0.383000													22	34					0	0	1	0	0	
FASTKD1	79675	broad.mit.edu	37	2	170393848	170393848	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:170393848T>C	uc002uev.3	-	12	2465	c.2077A>G	c.(2077-2079)ATT>GTT	p.I693V	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.I636V	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	693					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						ATGCCACCAATACCtttataa	0.229000													5	93					0	0	1	0	0	
CYBRD1	79901	broad.mit.edu	37	2	172379172	172379172	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:172379172C>T	uc002ugy.3	+	1	307	c.117C>T	c.(115-117)GGC>GGT	p.G39G	CYBRD1_uc002ugz.3_Silent_p.G39G	NM_024843	NP_079119	Q53TN4	CYBR1_HUMAN	cytochrome b reductase 1 isoform 1	39	Cytochrome b561.				cellular iron ion homeostasis|electron transport chain|transmembrane transport	integral to membrane	ferric-chelate reductase activity|metal ion binding				0						AGGGGCTTGGCTGGGATGGGA	0.642000													11	30					0	0	1	0	0	
ATF2	1386	broad.mit.edu	37	2	175962206	175962206	+	Nonsense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:175962206A>T	uc002ujl.2	-	11	1206	c.944T>A	c.(943-945)TTA>TAA	p.L315*	ATF2_uc010fqv.2_Nonsense_Mutation_p.L266*|ATF2_uc002ujv.2_Nonsense_Mutation_p.L62*|ATF2_uc002ujm.2_Nonsense_Mutation_p.L257*|ATF2_uc002ujn.2_RNA|ATF2_uc002ujo.2_Intron|ATF2_uc002ujp.2_RNA|ATF2_uc002ujq.2_Nonsense_Mutation_p.L315*|ATF2_uc002ujr.2_RNA|ATF2_uc010fqu.2_Nonsense_Mutation_p.L297*|ATF2_uc002ujs.2_Nonsense_Mutation_p.L257*|ATF2_uc002ujt.2_RNA|ATF2_uc002uju.2_RNA|ATF2_uc002ujw.1_Nonsense_Mutation_p.L257*|ATF2_uc002ujx.1_RNA	NM_001880	NP_001871	P15336	ATF2_HUMAN	activating transcription factor 2	315					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(1)|breast(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.125)			TGGCTGTTGTAATGACTGCGG	0.433000													42	85					0	0	1	0	0	
EVX2	344191	broad.mit.edu	37	2	176947159	176947159	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:176947159G>A	uc010zeu.1	-	2	632	c.446C>T	c.(445-447)TCG>TTG	p.S149L		NM_001080458	NP_001073927	Q03828	EVX2_HUMAN	even-skipped homeobox 2	149						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCCGGCAGCCGAGCCGCTCTC	0.721000													19	23					0	0	1	0	0	
HOXD4	3233	broad.mit.edu	37	2	177017378	177017378	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:177017378C>T	uc002uks.2	+	2	725	c.476C>T	c.(475-477)ACG>ATG	p.T159M		NM_014621	NP_055436	P09016	HXD4_HUMAN	homeobox D4	159	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00765)|Epithelial(96;0.105)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		CGGTCCCGAACGGCCTACACC	0.557000													23	45					0	0	1	0	0	
HOXD3	3232	broad.mit.edu	37	2	177036848	177036848	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:177036848C>T	uc002ukt.1	+	3	1321	c.1145C>T	c.(1144-1146)CCG>CTG	p.P382L		NM_006898	NP_008829	P31249	HXD3_HUMAN	homeobox D3	382					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		CTCTCGCACCCGTCGTCGGCC	0.662000													10	20					0	0	1	0	0	
HOXD1	3231	broad.mit.edu	37	2	177054164	177054164	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:177054164G>T	uc002ukv.3	+	1	858	c.635G>T	c.(634-636)AGG>ATG	p.R212M	HOXD1_uc010fqy.2_Missense_Mutation_p.R212M|HOXD1_uc010zez.1_Missense_Mutation_p.R212M	NM_024501	NP_078777	Q9GZZ0	HXD1_HUMAN	homeobox D1	212						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.0226)		AAAGTGAAGAGGAATGCCTCT	0.662000													11	33					1.36491e-13	1.4407e-13	1	1	0	
TTC30B	150737	broad.mit.edu	37	2	178416830	178416830	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:178416830T>C	uc002uln.2	-	1	695	c.662A>G	c.(661-663)CAG>CGG	p.Q221R	TTC30B_uc010zfc.1_5'UTR	NM_152517	NP_689730	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	221	TPR 4.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			CTCAGGGTGCTGGCGGATGCC	0.537000													19	49					0	0	1	0	0	
TTN	7273	broad.mit.edu	37	2	179396497	179396497	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:179396497G>A	uc010zfg.1	-	307	97365	c.97141C>T	c.(97141-97143)CGC>TGC	p.R32381C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R26076C|TTN_uc010zfi.1_Missense_Mutation_p.R26009C|TTN_uc010zfj.1_Missense_Mutation_p.R25884C|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33308							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTGCGAGCGCATTCTCAGT	0.443000													30	48					0	0	1	0	0	
TTN	7273	broad.mit.edu	37	2	179436014	179436014	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:179436014C>T	uc010zfg.1	-	275	67365	c.67141G>A	c.(67141-67143)GAA>AAA	p.E22381K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E16076K|TTN_uc010zfi.1_Missense_Mutation_p.E16009K|TTN_uc010zfj.1_Missense_Mutation_p.E15884K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23308							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTATTTCTTTCCTTGCGTTCT	0.413000													32	64					0	0	1	0	0	
TTN	7273	broad.mit.edu	37	2	179454179	179454179	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:179454179T>A	uc010zfg.1	-	253	54793	c.54569A>T	c.(54568-54570)GAG>GTG	p.E18190V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E11885V|TTN_uc010zfi.1_Missense_Mutation_p.E11818V|TTN_uc010zfj.1_Missense_Mutation_p.E11693V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19117							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACAACTTCCTCTGTCTTCAC	0.423000													17	25					0	0	1	0	0	
TTN	7273	broad.mit.edu	37	2	179463736	179463736	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:179463736T>C	uc010zfg.1	-	240	49221	c.48997A>G	c.(48997-48999)ATG>GTG	p.M16333V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.M10028V|TTN_uc010zfi.1_Missense_Mutation_p.M9961V|TTN_uc010zfj.1_Missense_Mutation_p.M9836V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17260							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGACAGTCATGGAGTTACGA	0.418000													16	18					0	0	1	0	0	
ZNF385B	151126	broad.mit.edu	37	2	180348060	180348060	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:180348060G>A	uc002unn.3	-	6	1213	c.609C>T	c.(607-609)AGC>AGT	p.S203S	ZNF385B_uc002unj.2_Silent_p.S101S|ZNF385B_uc002unk.2_RNA|ZNF385B_uc002unl.2_Silent_p.S100S|ZNF385B_uc002unm.2_Silent_p.S127S	NM_152520	NP_689733	Q569K4	Z385B_HUMAN	zinc finger protein 385B isoform 1	203						nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1			Epithelial(96;0.174)|OV - Ovarian serous cystadenocarcinoma(117;0.201)			TAGCCTTTGCGCTGTCCTTGG	0.453000													21	30					0	0	1	0	0	
ZNF804A	91752	broad.mit.edu	37	2	185801480	185801480	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:185801480A>C	uc002uph.2	+	4	1951	c.1357A>C	c.(1357-1359)ATT>CTT	p.I453L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	453						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAAACCATCAATTTCCTATAG	0.338000													41	61					0	0	1	0	0	
FAM171B	165215	broad.mit.edu	37	2	187626790	187626790	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:187626790T>C	uc002ups.2	+	8	1833	c.1721T>C	c.(1720-1722)ATG>ACG	p.M574T	FAM171B_uc002upr.1_Missense_Mutation_p.M541T|FAM171B_uc002upt.2_Missense_Mutation_p.M43T	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	574	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						GGCCAATTGATGGAACCAGTA	0.443000													28	39					0	0	1	0	0	
GTF3C3	9330	broad.mit.edu	37	2	197636558	197636558	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:197636558A>G	uc002uts.2	-	15	2264	c.2174T>C	c.(2173-2175)TTG>TCG	p.L725S	GTF3C3_uc010zgu.1_Missense_Mutation_p.L696S	NM_012086	NP_036218	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide	725						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(3)|breast(3)|pancreas(1)	7						TTTCAGCATCAAACGGAGACA	0.418000													35	34					0	0	1	0	0	
MARS2	92935	broad.mit.edu	37	2	198571099	198571099	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:198571099C>A	uc002uuq.2	+	1	1013	c.970C>A	c.(970-972)CTG>ATG	p.L324M	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	324					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	GCCTGCCTTCCTGTTAGGGGC	0.537000													74	125					1.1397e-45	1.23669e-45	1	1	0	
SATB2	23314	broad.mit.edu	37	2	200137060	200137060	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:200137060C>A	uc002uuy.1	-	11	2893	c.2076G>T	c.(2074-2076)GAG>GAT	p.E692D	SATB2_uc010fsq.1_Missense_Mutation_p.E574D|SATB2_uc002uuz.1_Missense_Mutation_p.E692D|SATB2_uc002uva.1_Missense_Mutation_p.E692D	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	692						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCAGCAGCTCCTCGTCCTTAT	0.557000													39	76					2.45108e-15	2.60189e-15	1	1	0	
ALS2CR4	65062	broad.mit.edu	37	2	202488987	202488987	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:202488987G>A	uc002uyh.1	-	14	1319	c.1218C>T	c.(1216-1218)GCC>GCT	p.A406A	ALS2CR4_uc002uyg.1_Silent_p.A398A|ALS2CR4_uc010zho.1_Silent_p.A201A	NM_001044385	NP_001037850	Q96Q45	TM237_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	430						integral to membrane	protein binding				0						ATTATGAAGAGGCTTTGATTT	0.328000													11	26					0	0	1	0	0	
INO80D	54891	broad.mit.edu	37	2	206872047	206872047	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:206872047G>A	uc002vaz.3	-	10	2284	c.1879C>T	c.(1879-1881)CGG>TGG	p.R627W		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	627					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						TCAGGTAGCCGTGGCAGGACA	0.383000													5	60					0	0	1	0	0	
MDH1B	130752	broad.mit.edu	37	2	207611098	207611098	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:207611098C>A	uc002vbs.2	-	8	1324	c.1269G>T	c.(1267-1269)GAG>GAT	p.E423D	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.E423D|MDH1B_uc010fuj.2_Missense_Mutation_p.E325D|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	423					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		AAGTTCCATTCTCAAATTTCA	0.393000													13	30					2.27111e-07	2.33363e-07	1	1	0	
CRYGC	1420	broad.mit.edu	37	2	208993062	208993062	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:208993062G>A	uc002vco.3	-	3	428	c.390C>T	c.(388-390)TGC>TGT	p.C130C		NM_020989	NP_066269	P07315	CRGC_HUMAN	crystallin, gamma C	130	Beta/gamma crystallin 'Greek key' 4.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		AGAGGACCCAGCAGCCCTCCA	0.632000													21	46					0	0	1	0	0	
CRYGB	1419	broad.mit.edu	37	2	209010699	209010699	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:209010699G>A	uc002vcp.3	-	2	84	c.51C>T	c.(49-51)TAC>TAT	p.Y17Y		NM_005210	NP_005201	P07316	CRGB_HUMAN	crystallin, gamma B	17	Beta/gamma crystallin 'Greek key' 1.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		TGGTGCATTCGTAGCTGCGGC	0.567000													35	59					0	0	1	0	0	
MAP2	4133	broad.mit.edu	37	2	210560785	210560785	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:210560785C>T	uc002vde.1	+	7	4139	c.3891C>T	c.(3889-3891)ACC>ACT	p.T1297T	MAP2_uc002vdc.1_Silent_p.T1297T|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.T1293T	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1297					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TAGTGCAAACCACAACTGATG	0.512000													43	77					0	0	1	0	0	
CPS1	1373	broad.mit.edu	37	2	211464228	211464228	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:211464228G>A	uc002vee.3	+	14	1624	c.1492G>A	c.(1492-1494)GCA>ACA	p.A498T	CPS1_uc010fur.2_Missense_Mutation_p.A504T|CPS1_uc010fus.2_Missense_Mutation_p.A47T	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	498					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GGTCATCAAGGCAGAACAGCC	0.468000													43	67					0	0	1	0	0	
ATIC	471	broad.mit.edu	37	2	216209520	216209520	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:216209520C>T	uc002vex.3	+	13	1420	c.1246C>T	c.(1246-1248)CGA>TGA	p.R416*	ATIC_uc010zjo.1_Nonsense_Mutation_p.R357*|ATIC_uc002vey.3_Nonsense_Mutation_p.R415*	NM_004044	NP_004035	P31939	PUR9_HUMAN	5-aminoimidazole-4-carboxamide ribonucleotide	416					IMP biosynthetic process|purine base metabolic process	cytosol	IMP cyclohydrolase activity|phosphoribosylaminoimidazolecarboxamide formyltransferase activity|protein homodimerization activity		ATIC/ALK(24)	haematopoietic_and_lymphoid_tissue(22)|ovary(2)|lung(2)|soft_tissue(2)|skin(1)	29		Renal(323;0.229)		Epithelial(149;2.02e-06)|all cancers(144;0.000316)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.0097)	Tetrahydrofolic acid(DB00116)	GTCTGCCCTCCGAGACCTCAT	0.433000			T	ALK	ALCL								24	29					0	0	1	0	0	
FN1	2335	broad.mit.edu	37	2	216286852	216286852	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:216286852C>T	uc002vfa.2	-	10	1774	c.1508G>A	c.(1507-1509)CGT>CAT	p.R503H	FN1_uc002vfb.2_Missense_Mutation_p.R503H|FN1_uc002vfc.2_Missense_Mutation_p.R503H|FN1_uc002vfd.2_Missense_Mutation_p.R503H|FN1_uc002vfe.2_Missense_Mutation_p.R503H|FN1_uc002vff.2_Missense_Mutation_p.R503H|FN1_uc002vfg.2_Missense_Mutation_p.R503H|FN1_uc002vfh.2_Missense_Mutation_p.R503H|FN1_uc002vfi.2_Missense_Mutation_p.R503H|FN1_uc002vfj.2_Missense_Mutation_p.R503H|FN1_uc002vfl.2_Missense_Mutation_p.R503H	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	503	Collagen-binding.|Fibronectin type-I 7.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCATTCCCCACGACCATTCCC	0.473000													47	78					0	0	1	0	0	
SMARCAL1	50485	broad.mit.edu	37	2	217315647	217315647	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:217315647C>T	uc002vgc.3	+	12	2260	c.1930C>T	c.(1930-1932)CGG>TGG	p.R644W	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.R644W|SMARCAL1_uc010fvg.2_Missense_Mutation_p.R622W	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	644			R -> W (in SIOD).		chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		AGTCATGCTGCGGCGCCTCAA	0.602000									Schimke_Immuno-Osseous_Dysplasia				25	58					0	0	1	0	0	
USP37	57695	broad.mit.edu	37	2	219362579	219362579	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:219362579G>A	uc002vie.2	-	13	1612	c.1159C>T	c.(1159-1161)CGC>TGC	p.R387C	USP37_uc010fvs.1_Missense_Mutation_p.R387C|USP37_uc010zkf.1_Missense_Mutation_p.R387C|USP37_uc002vif.2_Missense_Mutation_p.R387C|USP37_uc002vig.2_Missense_Mutation_p.R315C	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	387					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TGTGCAAAGCGTCTAGTAAAA	0.323000													32	43					0	0	1	0	0	
RNF25	64320	broad.mit.edu	37	2	219529162	219529162	+	Missense_Mutation	SNP	C	T	T	rs140256402	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:219529162C>T	uc002vit.2	-	10	986	c.898G>A	c.(898-900)GTC>ATC	p.V300I	RNF25_uc010fvw.2_Missense_Mutation_p.V188I	NM_022453	NP_071898	Q96BH1	RNF25_HUMAN	ring finger protein 25	300					positive regulation of NF-kappaB transcription factor activity	cytosol|nucleus	NF-kappaB binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Renal(207;0.0474)		Epithelial(149;6.99e-07)|all cancers(144;0.000129)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGATTGGACGGCTGGTGAG	0.567000													27	63					0	0	1	0	0	
ACCN4	55515	broad.mit.edu	37	2	220400033	220400033	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:220400033G>A	uc002vma.2	+	5	1554	c.1540G>A	c.(1540-1542)GAG>AAG	p.E514K	ACCN4_uc002vlz.2_Missense_Mutation_p.E533K|ACCN4_uc002vmb.2_Missense_Mutation_p.E187K	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	514	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		CAACCGCAACGAGACCTACAT	0.398000													6	10					0	0	1	0	0	
SLC4A3	6508	broad.mit.edu	37	2	220495067	220495067	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:220495067C>T	uc002vmp.3	+	6	1073	c.804C>T	c.(802-804)GAC>GAT	p.D268D	SLC4A3_uc002vmn.2_Silent_p.D295D|SLC4A3_uc002vmo.3_Silent_p.D295D|SLC4A3_uc010fwm.2_5'UTR|SLC4A3_uc010fwn.1_5'Flank	NM_005070	NP_005061	P48751	B3A3_HUMAN	solute carrier family 4, anion exchanger, member	268	Cytoplasmic.				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	5		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCTGGACGACATGAAGAGTG	0.637000													15	35					0	0	1	0	0	
SPHKAP	80309	broad.mit.edu	37	2	228881735	228881735	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:228881735T>C	uc002vpq.2	-	7	3882	c.3835A>G	c.(3835-3837)AGC>GGC	p.S1279G	SPHKAP_uc002vpp.2_Missense_Mutation_p.S1279G|SPHKAP_uc010zlx.1_Missense_Mutation_p.S1279G	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1279						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAGGACGCGCTACTGACCGGC	0.507000													28	50					0	0	1	0	0	
ALPPL2	251	broad.mit.edu	37	2	233272672	233272672	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:233272672G>A	uc002vss.3	+	5	646	c.593G>A	c.(592-594)CGC>CAC	p.R198H		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	198					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GCCTCGGCCCGCCAGGAGGGG	0.672000													42	78					0	0	1	0	0	
EFHD1	80303	broad.mit.edu	37	2	233546345	233546345	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:233546345G>T	uc002vtc.2	+	4	844	c.636G>T	c.(634-636)GAG>GAT	p.E212D	EFHD1_uc010fyf.2_Missense_Mutation_p.E116D|EFHD1_uc002vtd.2_Missense_Mutation_p.E100D	NM_025202	NP_079478	Q9BUP0	EFHD1_HUMAN	EF-hand domain family, member D1	212							calcium ion binding|protein binding				0		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Breast(86;0.0199)|Renal(207;0.025)		Epithelial(121;2.08e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00825)|Lung(119;0.0101)		TGAAAGCTGAGCAAGATGAGC	0.542000													56	81					3.93605e-18	4.20214e-18	1	1	0	
UGT1A5	54579	broad.mit.edu	37	2	234681073	234681073	+	Silent	SNP	C	T	T	rs114123636	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:234681073C>T	uc002vuw.2	+	5	1473	c.1473C>T	c.(1471-1473)GAC>GAT	p.D491D	UGT1A8_uc002vup.2_Silent_p.D487D|UGT1A10_uc002vur.2_Silent_p.D487D|UGT1A9_uc002vus.2_Silent_p.D487D|UGT1A7_uc002vut.2_Silent_p.D487D|UGT1A6_uc002vuu.2_Silent_p.D222D|UGT1A6_uc002vuv.3_Silent_p.D489D|UGT1A4_uc002vux.2_Silent_p.D491D|UGT1A3_uc002vuy.2_Silent_p.D491D|UGT1A9_uc002vva.2_RNA|UGT1A1_uc002vvb.2_Silent_p.D490D	NM_019078	NP_061951	P35504	UD15_HUMAN	UDP glycosyltransferase 1 family, polypeptide A5	491					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		ATTCCTTGGACGTGATTGGTT	0.567000													49	84					0	0	1	0	0	
AGAP1	116987	broad.mit.edu	37	2	237028996	237028996	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:237028996G>A	uc002vvs.2	+	17	2870	c.2275G>A	c.(2275-2277)GAG>AAG	p.E759K	AGAP1_uc002vvt.2_Missense_Mutation_p.E706K	NM_001037131	NP_001032208	Q9UPQ3	AGAP1_HUMAN	centaurin, gamma 2 isoform 1	759					protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			ovary(2)|skin(1)	3						CTCCCGGGACGAGGTGAACGA	0.716000													22	61					0	0	1	0	0	
MLPH	79083	broad.mit.edu	37	2	238449011	238449011	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:238449011C>T	uc002vwt.2	+	10	1352	c.1125C>T	c.(1123-1125)CGC>CGT	p.R375R	MLPH_uc002vws.2_Silent_p.R232R|MLPH_uc010fyt.1_Silent_p.R347R|MLPH_uc002vwu.2_Silent_p.R347R|MLPH_uc002vwv.2_Silent_p.R307R|MLPH_uc002vww.2_Silent_p.R323R|MLPH_uc002vwx.2_Silent_p.R231R|MLPH_uc010fyu.2_Silent_p.R127R	NM_024101	NP_077006	Q9BV36	MELPH_HUMAN	melanophilin isoform 1	375	Potential.						metal ion binding			ovary(1)	1		Breast(86;0.000381)|Renal(207;0.000966)|Ovarian(221;0.0695)|all_hematologic(139;0.095)|all_lung(227;0.17)|Melanoma(123;0.203)		Epithelial(121;1.17e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.02e-10)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.15e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000439)|Lung(119;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0316)		CTGGAGTGCGCACGGAGGCCG	0.622000													7	33					0	0	1	0	0	
ESPNL	339768	broad.mit.edu	37	2	239013386	239013386	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:239013386A>C	uc002vxq.3	+	3	685	c.575A>C	c.(574-576)AAG>ACG	p.K192T		NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	192	ANK 6.									pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		TTCCTGGTGAAGGACTGTGGC	0.682000													3	11					0	0	1	0	0	
HDAC4	9759	broad.mit.edu	37	2	240056118	240056118	+	Missense_Mutation	SNP	C	T	T	rs115644432	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:240056118C>T	uc002vyk.3	-	11	1909	c.1117G>A	c.(1117-1119)GCC>ACC	p.A373T	HDAC4_uc010fyz.1_Missense_Mutation_p.A368T|HDAC4_uc010zoa.1_Missense_Mutation_p.A368T|HDAC4_uc010fza.2_Missense_Mutation_p.A373T|HDAC4_uc010fyy.2_Missense_Mutation_p.A325T|HDAC4_uc010znz.1_Missense_Mutation_p.A256T|HDAC4_uc010fzb.1_RNA	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	373				A -> T (in Ref. 1; AAD29046 and 2; BAA22957).	B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		AGTCTCTCGGCGTCCTGCTGG	0.687000													4	13					0	0	1	0	0	
KIF1A	547	broad.mit.edu	37	2	241658494	241658494	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:241658494C>T	uc002vzy.2	-	45	4986	c.4840G>A	c.(4840-4842)GTG>ATG	p.V1614M	KIF1A_uc010fzk.2_Missense_Mutation_p.V1715M|KIF1A_uc002vzw.2_Missense_Mutation_p.V275M|KIF1A_uc002vzx.2_Missense_Mutation_p.V341M	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1614	PH.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AACCGCTCCACGGTGTCCTTG	0.657000													43	58					0	0	1	0	0	
PASK	23178	broad.mit.edu	37	2	242066771	242066771	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:242066771A>G	uc002wao.1	-	10	1651	c.1559T>C	c.(1558-1560)GTG>GCG	p.V520A	PASK_uc010zol.1_Missense_Mutation_p.V334A|PASK_uc010zom.1_Missense_Mutation_p.V485A|PASK_uc010fzl.1_Missense_Mutation_p.V520A|PASK_uc010zon.1_Missense_Mutation_p.V301A|PASK_uc002wap.2_Missense_Mutation_p.V63A|PASK_uc002waq.2_Missense_Mutation_p.V520A	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	520					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CTCTATTGCCACAGGTTCCTC	0.567000													62	95					0	0	1	0	0	
HDLBP	3069	broad.mit.edu	37	2	242196109	242196109	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:242196109C>T	uc002waz.2	-	6	791	c.563G>A	c.(562-564)CGC>CAC	p.R188H	HDLBP_uc002wba.2_Missense_Mutation_p.R188H|HDLBP_uc002wbb.2_Missense_Mutation_p.R209H|HDLBP_uc010fzn.1_5'UTR	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	188	KH 1.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		GTCATCTGGGCGTGGGATCTG	0.488000													45	61					0	0	1	0	0	
DEFB125	245938	broad.mit.edu	37	20	76799	76799	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:76799C>T	uc002wcw.2	+	2	212	c.212C>T	c.(211-213)CCT>CTT	p.P71L		NM_153325	NP_697020	Q8N687	DB125_HUMAN	defensin, beta 125 preproprotein	71					defense response to bacterium	extracellular region				ovary(1)|central_nervous_system(1)|skin(1)	3		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			CCAGCATTTCCTGTGATTCAC	0.363000													57	107					0	0	1	0	0	
SLC4A11	83959	broad.mit.edu	37	20	3211445	3211445	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:3211445G>A	uc002wig.2	-	10	1311	c.1263C>T	c.(1261-1263)TAC>TAT	p.Y421Y	SLC4A11_uc010zqe.1_Silent_p.Y448Y|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Silent_p.Y405Y	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	421	Helical; (Potential).|Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						AGAAGAGCGCGTAGAGCAGGC	0.682000													21	38					0	0	1	0	0	
JAG1	182	broad.mit.edu	37	20	10629262	10629262	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:10629262A>G	uc002wnw.2	-	12	2020	c.1504T>C	c.(1504-1506)TGT>CGT	p.C502R	JAG1_uc010gcd.1_Missense_Mutation_p.C60R	NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	502	EGF-like 8; calcium-binding (Potential).|Extracellular (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						TCATTCTGACAGTGACCCCCA	0.488000									Alagille_Syndrome				16	25					0	0	1	0	0	
ISM1	140862	broad.mit.edu	37	20	13279773	13279773	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:13279773C>T	uc010gce.1	+	6	1068	c.1062C>T	c.(1060-1062)CCC>CCT	p.P354P	TASP1_uc010zri.1_Intron	NM_080826	NP_543016	B1AKI9	ISM1_HUMAN	isthmin 1 homolog precursor	354	AMOP.					extracellular region					0						CCAGCGGGCCCAAGGAGAAGC	0.647000													5	16					0	0	1	0	0	
NINL	22981	broad.mit.edu	37	20	25442243	25442243	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:25442243T>C	uc002wux.1	-	21	3685	c.3611A>G	c.(3610-3612)GAA>GGA	p.E1204G	NINL_uc010gdn.1_Missense_Mutation_p.E855G|NINL_uc002wuw.1_5'Flank	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1204	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GCATTCAAGTTCAACTCTAAG	0.438000													27	32					0	0	1	0	0	
DEFB118	117285	broad.mit.edu	37	20	29960908	29960908	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:29960908G>T	uc002wvr.2	+	2	333	c.307G>T	c.(307-309)GTT>TTT	p.V103F		NM_054112	NP_473453	Q96PH6	DB118_HUMAN	beta-defensin 118 precursor	103					cell-matrix adhesion|defense response to bacterium|innate immune response|spermatogenesis	extracellular region				ovary(3)|pancreas(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			GAAAGATATGGTTGAAGAGTC	0.458000													33	33					6.53348e-20	6.99334e-20	1	1	0	
SNTA1	6640	broad.mit.edu	37	20	32000508	32000508	+	Missense_Mutation	SNP	G	A	A	rs139467962		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:32000508G>A	uc002wzd.1	-	4	1054	c.782C>T	c.(781-783)GCG>GTG	p.A261V	SNTA1_uc010zuf.1_Intron	NM_003098	NP_003089	Q13424	SNTA1_HUMAN	acidic alpha 1 syntrophin	261	PH 1.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			skin(1)	1						GATGGCAGTCGCCCACGACCT	0.607000													27	24					0	0	1	0	0	
CEP250	11190	broad.mit.edu	37	20	34092805	34092805	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:34092805A>C	uc002xcm.2	+	31	7279	c.6608A>C	c.(6607-6609)GAG>GCG	p.E2203A	CEP250_uc010zve.1_Missense_Mutation_p.E1571A	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	2203	Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			TCTGTCCTGGAGCGGGACTCA	0.607000													10	22					0	0	1	0	0	
DLGAP4	22839	broad.mit.edu	37	20	35127677	35127677	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:35127677G>A	uc002xff.2	+	9	2478	c.2043G>A	c.(2041-2043)TCG>TCA	p.S681S	DLGAP4_uc010zvp.1_Silent_p.S681S|DLGAP4_uc002xfg.2_Intron|DLGAP4_uc002xfh.2_Intron|DLGAP4_uc002xfi.2_5'UTR|DLGAP4_uc002xfj.2_5'UTR	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCCACCTCTCGGAGGACAACG	0.468000													25	32					0	0	1	0	0	
C20orf117	140710	broad.mit.edu	37	20	35444330	35444330	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:35444330G>A	uc002xgd.1	-	5	1128	c.801C>T	c.(799-801)TGC>TGT	p.C267C	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	267											0		Myeloproliferative disorder(115;0.00874)				AGCTCTCCCCGCACTCTCCGC	0.667000													8	9					0	0	1	0	0	
C20orf117	140710	broad.mit.edu	37	20	35444560	35444560	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:35444560C>T	uc002xgd.1	-	5	898	c.571G>A	c.(571-573)GCG>ACG	p.A191T	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	191											0		Myeloproliferative disorder(115;0.00874)				GCTGACAGCGCGCTGTCCAGG	0.617000													21	40					0	0	1	0	0	
KIAA0406	9675	broad.mit.edu	37	20	36640541	36640541	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:36640541T>C	uc002xhl.2	-	3	1887	c.1678A>G	c.(1678-1680)ATA>GTA	p.I560V	KIAA0406_uc002xhm.2_Missense_Mutation_p.I560V	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	560							binding				0		Myeloproliferative disorder(115;0.00874)				TCTTCAAGTATAGATGTCACA	0.433000													80	102					0	0	1	0	0	
PPP1R16B	26051	broad.mit.edu	37	20	37536791	37536791	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:37536791C>T	uc002xje.2	+	10	1338	c.1149C>T	c.(1147-1149)AAC>AAT	p.N383N	PPP1R16B_uc010ggc.2_Silent_p.N341N	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	383					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				CCACCTACAACGGGGACATCA	0.592000													23	40					0	0	1	0	0	
PLCG1	5335	broad.mit.edu	37	20	39798904	39798904	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:39798904G>A	uc002xjp.1	+	24	2924	c.2803G>A	c.(2803-2805)GCC>ACC	p.A935T	PLCG1_uc002xjo.1_Missense_Mutation_p.A935T|PLCG1_uc010zwe.1_Missense_Mutation_p.A561T|PLCG1_uc010ggf.2_Missense_Mutation_p.A259T	NM_182811	NP_877963	P19174	PLCG1_HUMAN	phospholipase C, gamma 1 isoform b	935					activation of phospholipase C activity|axon guidance|blood coagulation|cellular response to epidermal growth factor stimulus|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular signal transduction|leukocyte migration|nerve growth factor receptor signaling pathway|phospholipid catabolic process|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of epithelial cell migration|T cell receptor signaling pathway	cytosol|lamellipodium|plasma membrane|ruffle	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|receptor signaling protein activity			lung(3)|breast(3)|skin(2)	8		Myeloproliferative disorder(115;0.00878)				GACAGCAGACGCCAGGGTGAG	0.647000													16	27					0	0	1	0	0	
CHD6	84181	broad.mit.edu	37	20	40045241	40045241	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:40045241G>A	uc002xka.1	-	33	6651	c.6473C>T	c.(6472-6474)GCC>GTC	p.A2158V	CHD6_uc002xjz.1_5'Flank	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2158					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GTGGATCTGGGCCGCCAATGC	0.517000													50	81					0	0	1	0	0	
PABPC1L	80336	broad.mit.edu	37	20	43545401	43545401	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:43545401C>T	uc010ggv.1	+	3	474	c.392C>T	c.(391-393)GCG>GTG	p.A131V	PABPC1L_uc010zwq.1_RNA	NM_001124756	NP_001118228	Q4VXU2	PAP1L_HUMAN	poly(A)-binding protein, cytoplasmic 1-like	131	RRM 2.						nucleotide binding|RNA binding			ovary(1)	1						GCCCAGGTGGCGTGTGACGAG	0.562000													55	115					0	0	1	0	0	
C20orf165	128497	broad.mit.edu	37	20	44515246	44515246	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:44515246C>T	uc002xqf.2	-	2	603	c.594G>A	c.(592-594)GCG>GCA	p.A198A		NM_080608	NP_542175	Q9BR10	CT165_HUMAN	chromosome 20 open reading frame 165	198						integral to membrane					0		Myeloproliferative disorder(115;0.0122)				GCTCCCACCGCGCCCCCTCCA	0.622000													45	58					0	0	1	0	0	
CTSA	5476	broad.mit.edu	37	20	44527008	44527008	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:44527008C>T	uc002xqj.3	+	15	1836	c.1362C>T	c.(1360-1362)GGC>GGT	p.G454G	CTSA_uc002xqh.2_Silent_p.G472G|CTSA_uc002xqi.2_RNA|CTSA_uc010zxi.1_Silent_p.G455G|CTSA_uc002xqk.3_Silent_p.G454G	NM_001127695	NP_001121167	P10619	PPGB_HUMAN	cathepsin A isoform b precursor	454					intracellular protein transport|proteolysis	endoplasmic reticulum|lysosome|nucleus	enzyme activator activity|protein binding|serine-type carboxypeptidase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CTCCTCAGGGCGCCGGCCACA	0.572000													8	17					0	0	1	0	0	
MMP9	4318	broad.mit.edu	37	20	44639150	44639150	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:44639150C>T	uc002xqz.2	+	3	419	c.400C>T	c.(400-402)CGG>TGG	p.R134W		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	134					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	AGACTTGCCGCGGGCGGTGAT	0.617000													25	36					0	0	1	0	0	
MMP9	4318	broad.mit.edu	37	20	44641102	44641102	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:44641102G>A	uc002xqz.2	+	8	1230	c.1211G>A	c.(1210-1212)GGC>GAC	p.G404D		NM_004994	NP_004985	P14780	MMP9_HUMAN	matrix metalloproteinase 9 preproprotein	404					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CATGAGTTCGGCCACGCGCTG	0.642000													30	53					0	0	1	0	0	
SLC12A5	57468	broad.mit.edu	37	20	44669091	44669091	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:44669091G>A	uc010zxl.1	+	7	837	c.761G>A	c.(760-762)CGT>CAT	p.R254H	SLC12A5_uc002xra.2_Missense_Mutation_p.R231H|SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.R231H	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	254	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	AACAACATGCGTGTTTACGGC	0.547000													29	42					0	0	1	0	0	
SLC12A5	57468	broad.mit.edu	37	20	44671923	44671923	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:44671923T>G	uc010zxl.1	+	9	1343	c.1267T>G	c.(1267-1269)TTC>GTC	p.F423V	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.F400V	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	423	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GACCTCCTACTTCACCCTGCT	0.562000													112	126					0	0	1	0	0	
ELMO2	63916	broad.mit.edu	37	20	44997547	44997547	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:44997547C>T	uc002xrt.1	-	21	2155	c.1945G>A	c.(1945-1947)GCA>ACA	p.A649T	ELMO2_uc010zxq.1_Missense_Mutation_p.A381T|ELMO2_uc002xrs.1_Missense_Mutation_p.A396T|ELMO2_uc002xru.1_Missense_Mutation_p.A649T|ELMO2_uc010zxr.1_Missense_Mutation_p.A661T|ELMO2_uc010zxs.1_Missense_Mutation_p.A466T	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	649	PH.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TTATTAGGTGCGATGAAGTTT	0.458000													41	94					0	0	1	0	0	
ELMO2	63916	broad.mit.edu	37	20	45017707	45017707	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:45017707G>T	uc002xrt.1	-	7	606	c.396C>A	c.(394-396)CTC>CTA	p.L132L	ELMO2_uc002xru.1_Silent_p.L132L|ELMO2_uc010zxr.1_Silent_p.L132L|ELMO2_uc010zxs.1_5'UTR|ELMO2_uc002xrw.2_5'Flank|ELMO2_uc002xrx.1_Silent_p.L132L	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	132					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CACTTTCCACGAGCCTTGTCA	0.522000													24	43					7.07758e-08	7.29798e-08	1	1	0	
SLC2A10	81031	broad.mit.edu	37	20	45354006	45354006	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:45354006G>A	uc002xsl.2	+	2	428	c.331G>A	c.(331-333)GCC>ACC	p.A111T		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	111	Helical; Name=4; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GGTTGGCTTCGCCATTTCCCT	0.652000													35	52					0	0	1	0	0	
SULF2	55959	broad.mit.edu	37	20	46295140	46295140	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:46295140C>T	uc002xto.2	-	12	1999	c.1669G>A	c.(1669-1671)GCC>ACC	p.A557T	SULF2_uc002xtr.2_Missense_Mutation_p.A557T|SULF2_uc002xtq.2_Missense_Mutation_p.A557T|SULF2_uc010zyd.1_5'Flank	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	557					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CGGGGCTGGGCGGCATCACCC	0.647000													35	67					0	0	1	0	0	
SULF2	55959	broad.mit.edu	37	20	46307454	46307454	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:46307454G>T	uc002xto.2	-	8	1489	c.1159C>A	c.(1159-1161)CTC>ATC	p.L387I	SULF2_uc002xtr.2_Missense_Mutation_p.L387I|SULF2_uc002xtq.2_Missense_Mutation_p.L387I	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	387					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						AGCAGCTTGAGGATGGATTTC	0.607000													57	133					2.2129e-31	2.39488e-31	1	1	0	
ARFGEF2	10564	broad.mit.edu	37	20	47605105	47605105	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:47605105G>T	uc002xtx.3	+	18	2591	c.2439G>T	c.(2437-2439)GAG>GAT	p.E813D	ARFGEF2_uc010zyf.1_Missense_Mutation_p.E106D	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	813					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TGCCAGAAGAGTATCTCTCAA	0.313000													38	47					3.2961e-07	3.38175e-07	1	1	0	
SLC9A8	23315	broad.mit.edu	37	20	48472053	48472053	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:48472053C>T	uc002xuv.1	+	8	858	c.648C>T	c.(646-648)CCC>CCT	p.P216P	SLC9A8_uc010zym.1_5'UTR|SLC9A8_uc010zyj.1_Silent_p.P232P|SLC9A8_uc010zyk.1_Missense_Mutation_p.R205C|SLC9A8_uc010zyl.1_Missense_Mutation_p.R177C|SLC9A8_uc010gib.1_Missense_Mutation_p.R171C	NM_015266	NP_056081	Q9Y2E8	SL9A8_HUMAN	sodium/hydrogen exchanger 8	216						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			ATGTGGACCCCGTGCTCAACA	0.473000													37	55					0	0	1	0	0	
PTPN1	5770	broad.mit.edu	37	20	49196318	49196318	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:49196318C>T	uc002xvl.2	+	8	1117	c.943C>T	c.(943-945)CGA>TGA	p.R315*	PTPN1_uc010zys.1_Nonsense_Mutation_p.R242*	NM_002827	NP_002818	P18031	PTN1_HUMAN	protein tyrosine phosphatase, non-receptor type	315					blood coagulation|interferon-gamma-mediated signaling pathway|negative regulation of insulin receptor signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol|endoplasmic reticulum membrane	protein tyrosine phosphatase activity|zinc ion binding				0		Lung NSC(126;0.163)			Clodronate(DB00720)|Tiludronate(DB01133)	GCCACCCAAACGAATCCTGGA	0.567000											OREG0026029	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	59					0	0	1	0	0	
C20orf43	51507	broad.mit.edu	37	20	55093208	55093208	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:55093208G>A	uc002xxt.2	+	9	915	c.808G>A	c.(808-810)GCT>ACT	p.A270T	C20orf43_uc010zzf.1_Missense_Mutation_p.A300T|C20orf43_uc002xxu.2_Missense_Mutation_p.A269T|C20orf43_uc002xxv.2_3'UTR|GCNT7_uc010zzg.1_Intron	NM_016407	NP_057491	Q9BY42	CT043_HUMAN	hypothetical protein LOC51507	270										ovary(1)	1			Colorectal(105;0.202)			GAGGTCCATCGCTGACAGTGA	0.542000													33	50					0	0	1	0	0	
STX16	8675	broad.mit.edu	37	20	57246273	57246273	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:57246273C>T	uc002xzi.2	+	7	1447	c.712C>T	c.(712-714)CGA>TGA	p.R238*	STX16_uc010zzq.1_Nonsense_Mutation_p.R52*|STX16_uc002xzk.2_Nonsense_Mutation_p.R221*|STX16_uc002xzm.2_Nonsense_Mutation_p.R234*|STX16_uc002xzj.2_Nonsense_Mutation_p.R217*|STX16_uc002xzl.2_Nonsense_Mutation_p.R52*	NM_001001433	NP_001001433	O14662	STX16_HUMAN	syntaxin 16 isoform a	238	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			ovary(1)	1	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			AGAGCGGGAACGAGAGATTCG	0.473000													41	54					0	0	1	0	0	
GNAS	2778	broad.mit.edu	37	20	57485424	57485424	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:57485424C>T	uc002xzw.2	+	12	3220	c.2935C>T	c.(2935-2937)CGG>TGG	p.R979W	GNAS_uc002xzt.2_3'UTR|GNAS_uc010gjq.2_Missense_Mutation_p.R277W|GNAS_uc002xzx.2_Missense_Mutation_p.R277W|GNAS_uc010gjr.2_Missense_Mutation_p.R227W|GNAS_uc002xzy.2_Missense_Mutation_p.R262W|GNAS_uc002yaa.2_Missense_Mutation_p.R322W|GNAS_uc010zzt.1_Missense_Mutation_p.R337W|GNAS_uc002yab.2_Intron|GNAS_uc002yad.2_Missense_Mutation_p.R227W|GNAS_uc002yae.2_Missense_Mutation_p.R261W	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	336					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			ACGCGTGACCCGGGCCAAGTA	0.443000			Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			16	37					0	0	1	0	0	
ZNF831	128611	broad.mit.edu	37	20	57766438	57766438	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:57766438C>T	uc002yan.2	+	1	364	c.364C>T	c.(364-366)CCT>TCT	p.P122S		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	122						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGCACTCTGCCTGTCCTGTC	0.682000													14	25					0	0	1	0	0	
LAMA5	3911	broad.mit.edu	37	20	60887229	60887229	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:60887229C>T	uc002ycq.2	-	69	9571	c.9504G>A	c.(9502-9504)CCG>CCA	p.P3168P		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	3168	Laminin G-like 3.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGGTCTCACCGGGGACGCCC	0.687000													6	5					0	0	1	0	0	
BHLHE23	128408	broad.mit.edu	37	20	61637728	61637728	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:61637728G>A	uc002yeb.2	-	1	660	c.351C>T	c.(349-351)AAC>AAT	p.N117N		NM_080606	NP_542173	Q8NDY6	BHE23_HUMAN	basic helix-loop-helix domain containing, class	117	Helix-loop-helix motif.				transcription, DNA-dependent	nucleus	DNA binding				0						CCAGCGCGTCGTTTAGGTCGT	0.368000													12	9					0	0	1	0	0	
COL20A1	57642	broad.mit.edu	37	20	61941805	61941805	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:61941805G>A	uc011aau.1	+	11	1436	c.1336G>A	c.(1336-1338)GTG>ATG	p.V446M	COL20A1_uc011aav.1_Missense_Mutation_p.V267M	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	446	Fibronectin type-III 2.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					CCTGGTCTCCGTGTTCCCCAT	0.687000													7	12					0	0	1	0	0	
CHRNA4	1137	broad.mit.edu	37	20	61981737	61981737	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:61981737G>T	uc002yes.2	-	5	1204	c.1026C>A	c.(1024-1026)ACC>ACA	p.T342T	CHRNA4_uc002yet.1_Silent_p.T166T|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.T271T|CHRNA4_uc002yev.1_Silent_p.T166T|CHRNA4_uc010gkf.1_Silent_p.T166T	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	342	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TGCGTACCCAGGTGGGCATGG	0.617000													4	72					0.00909568	0.00915813	1	1	0	
DNAJC5	80331	broad.mit.edu	37	20	62560719	62560719	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:62560719G>A	uc002yhf.2	+	3	332	c.162G>A	c.(160-162)GCG>GCA	p.A54A	DNAJC5_uc002yhg.1_Silent_p.A54A|DNAJC5_uc002yhh.2_RNA	NM_025219	NP_079495	Q9H3Z4	DNJC5_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	54	J.				neurotransmitter secretion|protein folding	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|melanosome|plasma membrane	heat shock protein binding|unfolded protein binding			pancreas(1)	1	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CGGAGGCCGCGGACAAGTTTA	0.552000													24	31					0	0	1	0	0	
UCKL1	54963	broad.mit.edu	37	20	62571561	62571561	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:62571561G>A	uc010gkn.2	-	14	1552	c.1509C>T	c.(1507-1509)ATC>ATT	p.I503I	UCKL1_uc002yhj.2_Silent_p.I146I|UCKL1_uc011abm.1_Silent_p.I488I|UCKL1_uc011abn.1_RNA	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	uridine-cytidine kinase 1-like 1	503					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCGTGGTGATGATTCTCACTC	0.592000													17	30					0	0	1	0	0	
ZNF512B	57473	broad.mit.edu	37	20	62597786	62597786	+	Missense_Mutation	SNP	C	T	T	rs148308453		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:62597786C>T	uc002yhl.1	-	5	796	c.742G>A	c.(742-744)GTC>ATC	p.V248I		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					GCCTTGGTGACGGGCATGGGC	0.597000													118	246					0	0	1	0	0	
TPTE	7179	broad.mit.edu	37	21	10951271	10951271	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:10951271T>C	uc002yip.1	-	10	809	c.441A>G	c.(439-441)GTA>GTG	p.V147V	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.V129V|TPTE_uc002yir.1_Silent_p.V109V|TPTE_uc010gkv.1_Silent_p.V9V	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	147	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTACCTTTCTACAAATACTC	0.229000													15	66					0	0	1	0	0	
TPTE	7179	broad.mit.edu	37	21	10996060	10996060	+	RNA	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:10996060G>T	uc002yis.1	-	12		c.2126C>A						P56180	TPTE_HUMAN	Homo sapiens putative tyrosine phosphatase mRNA, complete cds.						signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGAGCCTGAGGAATCTTTTC	0.383000													12	38					7.03913e-09	7.29497e-09	1	1	0	
NCAM2	4685	broad.mit.edu	37	21	22370819	22370819	+	Translation_Start_Site	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:22370819G>T	uc002yld.1	+	1	187	c.-62G>T	c.(-64--60)AAGGT>AATGT		NCAM2_uc011acb.1_Translation_Start_Site	NM_004540	NP_004531	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2 precursor						neuron cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)	4		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GGCAGCGAAAGGTTCTCTCTC	0.423000													8	8					1.06961e-07	1.10181e-07	1	1	0	
GABPA	2551	broad.mit.edu	37	21	27137032	27137032	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:27137032C>T	uc002ylx.3	+	9	1597	c.1070C>T	c.(1069-1071)GCA>GTA	p.A357V	GABPA_uc002yly.3_Missense_Mutation_p.A357V	NM_002040	NP_002031	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha	357	ETS.				positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)|central_nervous_system(1)	2						GAACTGGTTGCACAGAAATGG	0.388000													33	67					0	0	1	0	0	
SYNJ1	8867	broad.mit.edu	37	21	34058147	34058147	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:34058147C>A	uc002yqh.2	-	9	1146	c.1146G>T	c.(1144-1146)AAG>AAT	p.K382N	SYNJ1_uc011ads.1_Missense_Mutation_p.K343N|SYNJ1_uc002yqf.2_Missense_Mutation_p.K343N|SYNJ1_uc002yqg.2_Missense_Mutation_p.K343N|SYNJ1_uc002yqi.2_Missense_Mutation_p.K382N	NM_003895	NP_003886	O43426	SYNJ1_HUMAN	synaptojanin 1 isoform a	343	SAC.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			ovary(4)|skin(1)	5						ATTTTTCTGCCTTTCCTCCCT	0.338000													4	70					0.000602214	0.000609638	1	1	0	
KCNJ6	3763	broad.mit.edu	37	21	38997730	38997730	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:38997730G>A	uc011aej.1	-	4	1056	c.1003C>T	c.(1003-1005)CGG>TGG	p.R335W	KCNJ6_uc002ywo.2_Missense_Mutation_p.R335W	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	335	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	GGTGTGAACCGGTAACCCCAC	0.527000													19	39					0	0	1	0	0	
BRWD1	54014	broad.mit.edu	37	21	40627704	40627704	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:40627704G>A	uc002yxk.1	-	19	2261	c.2122C>T	c.(2122-2124)CGT>TGT	p.R708C	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.R708C|BRWD1_uc010goe.1_RNA|BRWD1_uc010gof.1_Missense_Mutation_p.R161C|BRWD1_uc010gog.1_RNA|BRWD1_uc010goh.1_Intron|BRWD1_uc010goi.1_Missense_Mutation_p.R428C	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	708					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CCACTACGACGCAGACCAATA	0.438000													20	44					0	0	1	0	0	
UMODL1	89766	broad.mit.edu	37	21	43508547	43508547	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:43508547C>T	uc002zaf.1	+	5	747	c.747C>T	c.(745-747)GAC>GAT	p.D249D	UMODL1_uc002zad.1_Silent_p.D177D|UMODL1_uc002zae.1_Silent_p.D177D|UMODL1_uc002zag.1_Silent_p.D249D|UMODL1_uc010gow.1_Silent_p.D41D|UMODL1_uc002zai.1_5'UTR|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Intron|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Silent_p.D41D	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	249	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TGCTGGGTGACATTGCGAAGC	0.637000													9	24					0	0	1	0	0	
ABCG1	9619	broad.mit.edu	37	21	43702507	43702507	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:43702507A>G	uc002zaq.2	+	6	818	c.712A>G	c.(712-714)ATG>GTG	p.M238V	ABCG1_uc002zan.2_Missense_Mutation_p.M240V|ABCG1_uc002zam.2_Missense_Mutation_p.M216V|ABCG1_uc002zao.2_Missense_Mutation_p.M235V|ABCG1_uc002zap.2_Missense_Mutation_p.M238V|ABCG1_uc002zar.2_Missense_Mutation_p.M249V|ABCG1_uc011aev.1_Missense_Mutation_p.M249V	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	238	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	CCCTCCAGTCATGTTCTTCGA	0.617000													24	40					0	0	1	0	0	
TRPM2	7226	broad.mit.edu	37	21	45784127	45784127	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:45784127G>A	uc002zet.1	+	4	598	c.385G>A	c.(385-387)GAC>AAC	p.D129N	TRPM2_uc002zeu.1_Missense_Mutation_p.D129N|TRPM2_uc002zew.1_Missense_Mutation_p.D129N|TRPM2_uc010gpt.1_Missense_Mutation_p.D129N	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	129	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGCCTTTGGCGACATCGTCTT	0.567000													24	59					0	0	1	0	0	
TRPM2	7226	broad.mit.edu	37	21	45833790	45833790	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:45833790G>A	uc002zet.1	+	21	3192	c.2979G>A	c.(2977-2979)CCG>CCA	p.P993P	TRPM2_uc002zeu.1_Silent_p.P993P|TRPM2_uc002zew.1_Silent_p.P993P|TRPM2_uc010gpt.1_Silent_p.P993P|TRPM2_uc002zex.1_Silent_p.P779P|TRPM2_uc002zey.1_Silent_p.P506P	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	993	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACTTCAACCCGGAGCACTGCA	0.642000													87	132					0	0	1	0	0	
C21orf29	54084	broad.mit.edu	37	21	45924736	45924736	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:45924736C>A	uc002zfe.1	-	11	1849	c.1783G>T	c.(1783-1785)GGA>TGA	p.G595*	C21orf29_uc010gpv.1_Nonsense_Mutation_p.G527*	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	595	EAR 6.				cell adhesion	extracellular region	structural molecule activity				0						TAATCTTCTCCCACCGAGAAA	0.453000													24	44					7.01153e-11	7.33674e-11	1	1	0	
C21orf29	54084	broad.mit.edu	37	21	45947323	45947323	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:45947323C>T	uc002zfe.1	-	7	1067	c.1001G>A	c.(1000-1002)CGC>CAC	p.R334H	C21orf29_uc010gpv.1_Missense_Mutation_p.R266H	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	334	EAR 1.				cell adhesion	extracellular region	structural molecule activity				0						CTGAGGGATGCGGAACACCTC	0.522000													49	57					0	0	1	0	0	
KRTAP10-10	353333	broad.mit.edu	37	21	46057780	46057780	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:46057780C>A	uc002zfq.2	+	1	508	c.446C>A	c.(445-447)CCT>CAT	p.P149H	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	149	15 X 5 AA repeats of C-C-X(3).|10.					keratin filament					0						TGCTGTGTGCCTGTCTGCTCT	0.577000													135	202					8.93811e-64	9.71925e-64	1	1	0	
PCBP3	54039	broad.mit.edu	37	21	47333910	47333910	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:47333910T>A	uc002zhq.1	+	8	771	c.646T>A	c.(646-648)TCC>ACC	p.S216T	PCBP3_uc010gqb.2_Missense_Mutation_p.S216T|PCBP3_uc002zhp.1_Missense_Mutation_p.S216T|PCBP3_uc010gqc.1_Intron|PCBP3_uc002zhs.1_Intron|PCBP3_uc002zhr.1_Missense_Mutation_p.S216T|PCBP3_uc002zht.1_Missense_Mutation_p.S184T	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	216					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		AAAGCCCGCCTCCACCCCTGT	0.622000													31	43					0	0	1	0	0	
CECR1	51816	broad.mit.edu	37	22	17687997	17687997	+	Missense_Mutation	SNP	C	T	T	rs77563738	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:17687997C>T	uc002zmk.1	-	2	718	c.506G>A	c.(505-507)CGG>CAG	p.R169Q	CECR1_uc010gqu.1_Missense_Mutation_p.R169Q|CECR1_uc011agi.1_Missense_Mutation_p.R127Q|CECR1_uc011agj.1_Missense_Mutation_p.R127Q	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	cat eye syndrome critical region protein 1	169	PRB domain.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			ovary(1)	1		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				CACCCGCTTCCGATAATCCTC	0.512000													24	35					0	0	1	0	0	
HIRA	7290	broad.mit.edu	37	22	19344515	19344515	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:19344515C>T	uc002zpf.1	-	19	2514	c.2294G>A	c.(2293-2295)CGC>CAC	p.R765H	HIRA_uc011agx.1_Missense_Mutation_p.R631H|HIRA_uc010grn.1_Intron|HIRA_uc010gro.1_Missense_Mutation_p.R721H|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	765	Interaction with PAX3 (By similarity).|Interaction with histone H2B.|Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GAGGAGACGGCGACCACAGGT	0.587000													75	131					0	0	1	0	0	
COMT	1312	broad.mit.edu	37	22	19956139	19956139	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:19956139C>T	uc002zqu.2	+	6	945	c.696C>T	c.(694-696)CAC>CAT	p.H232H	COMT_uc002zqv.2_Silent_p.H232H|COMT_uc002zqw.2_Silent_p.H232H|COMT_uc011ahd.1_Silent_p.H232H|COMT_uc002zqx.2_Silent_p.H232H	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	232					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	TCCTAGCACACGTGCGCGGGA	0.607000													18	25					0	0	1	0	0	
ZNF74	7625	broad.mit.edu	37	22	20759882	20759882	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:20759882G>A	uc010gsm.2	+	6	771	c.559G>A	c.(559-561)GCC>ACC	p.A187T	ZNF74_uc002zsg.2_Missense_Mutation_p.A116T|ZNF74_uc002zsh.2_Missense_Mutation_p.A187T|ZNF74_uc002zsi.2_Missense_Mutation_p.A116T|ZNF74_uc010gsn.2_Missense_Mutation_p.A116T	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	187					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TCCCCTCTTCGCCCAGCAACG	0.667000													13	6					0	0	1	0	0	
KLHL22	84861	broad.mit.edu	37	22	20796462	20796462	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:20796462C>T	uc002zsl.1	-	7	1912	c.1803G>A	c.(1801-1803)CCG>CCA	p.P601P	KLHL22_uc011ahr.1_Silent_p.P458P	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	601					cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TCCCGCGGGGCGGCTCAAGGA	0.652000													10	19					0	0	1	0	0	
HIC2	23119	broad.mit.edu	37	22	21799658	21799658	+	Silent	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:21799658G>C	uc002zur.3	+	3	704	c.474G>C	c.(472-474)CGG>CGC	p.R158R	HIC2_uc002zus.3_Silent_p.R158R	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	158					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			skin(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GCATGGGGCGGCCCCCCCGCA	0.716000													8	7					0	0	1	0	0	
LOC96610	96610	broad.mit.edu	37	22	22712343	22712343	+	RNA	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:22712343C>T	uc011aim.1	+	41		c.4131C>T								Parts of antibodies, mostly variable regions.												0						CCACCCTCAGCGTCTGGGACC	0.552000													3	38					0	0	1	0	0	
LOC96610	96610	broad.mit.edu	37	22	22735449	22735449	+	RNA	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:22735449C>T	uc011aim.1	+	46		c.5245C>T								Parts of antibodies, mostly variable regions.												0						CCACCCTCAGCGTCTGGGACC	0.552000													73	16					0	0	1	0	0	
UPB1	51733	broad.mit.edu	37	22	24911250	24911250	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:24911250G>A	uc003aaf.2	+	6	824	c.703G>A	c.(703-705)GGG>AGG	p.G235R	UPB1_uc003aae.2_Missense_Mutation_p.G167R|UPB1_uc011ajt.1_Missense_Mutation_p.G235R	NM_016327	NP_057411	Q9UBR1	BUP1_HUMAN	beta-ureidopropionase	235	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			ovary(2)	2	Colorectal(2;0.0339)					CATTTGCTACGGGCGGCACCA	0.557000													46	69					0	0	1	0	0	
CRYBB1	1414	broad.mit.edu	37	22	27008142	27008142	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:27008142C>T	uc003acy.1	-	3	263	c.193G>A	c.(193-195)GAA>AAA	p.E65K		NM_001887	NP_001878	P53674	CRBB1_HUMAN	crystallin, beta B1	65	Beta/gamma crystallin 'Greek key' 1.				visual perception		structural constituent of eye lens			ovary(1)	1						TTTTCCAGTTCGAAGACCACC	0.537000													50	13					0	0	1	0	0	
TBC1D10A	83874	broad.mit.edu	37	22	30690039	30690039	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:30690039C>T	uc011akt.1	-	7	790	c.766G>A	c.(766-768)GCC>ACC	p.A256T	GATSL3_uc003ahf.2_RNA|GATSL3_uc003ahg.2_RNA|GATSL3_uc003ahh.2_RNA|GATSL3_uc010gvq.2_RNA|GATSL3_uc003ahi.2_Missense_Mutation_p.A114T|TBC1D10A_uc003ahj.3_Missense_Mutation_p.A168T|TBC1D10A_uc010gvu.2_Missense_Mutation_p.A263T|TBC1D10A_uc003ahk.3_Missense_Mutation_p.A256T	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	256	Rab-GAP TBC.					intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						TGCTTGTGGGCCACCGGCGAC	0.602000													36	51					0	0	1	0	0	
PES1	23481	broad.mit.edu	37	22	30980630	30980630	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:30980630G>A	uc003aij.1	-	5	517	c.443C>T	c.(442-444)CCG>CTG	p.P148L	PES1_uc003aik.1_Missense_Mutation_p.P148L|PES1_uc003ail.1_Missense_Mutation_p.P148L|PES1_uc003aim.1_Missense_Mutation_p.P148L|PES1_uc003ain.1_Missense_Mutation_p.P9L|PES1_uc003aio.1_Missense_Mutation_p.P9L	NM_014303	NP_055118	O00541	PESC_HUMAN	pescadillo homolog 1, containing BRCT domain	148	Sufficient for nucleolar localization.				cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|regulation of cell cycle	chromosome|nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						GCCAGTCCGCGGGAAGGTGGA	0.607000													13	14					0	0	1	0	0	
SELM	140606	broad.mit.edu	37	22	31501001	31501001	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:31501001C>T	uc011ali.1	-	6	453	c.393G>A	c.(391-393)GCG>GCA	p.A131A	SELM_uc011alj.1_RNA|INPP5J_uc010gwf.2_5'Flank	NM_080430	NP_536355	Q8WWX9	SELM_HUMAN	selenoprotein M precursor	131						endoplasmic reticulum|Golgi apparatus|nucleus|perinuclear region of cytoplasm					0						GCTTCGCGGGCGCCCACACGT	0.667000													8	24					0	0	1	0	0	
RASD2	23551	broad.mit.edu	37	22	35943100	35943100	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:35943100G>A	uc003anx.2	+	2	449	c.244G>A	c.(244-246)GCC>ACC	p.A82T	RASD2_uc003any.2_Missense_Mutation_p.A82T	NM_014310	NP_055125	Q96D21	RHES_HUMAN	RASD family, member 2 precursor	82					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			lung(2)|skin(1)	3						CCCCTTCCCCGCCATGCGCAG	0.642000													65	26					0	0	1	0	0	
TMPRSS6	164656	broad.mit.edu	37	22	37482393	37482393	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:37482393G>A	uc003aqs.1	-	8	1044	c.930C>T	c.(928-930)GTC>GTT	p.V310V	TMPRSS6_uc003aqt.1_Silent_p.V301V|TMPRSS6_uc003aqu.2_Silent_p.V301V	NM_153609	NP_705837	Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	310	CUB 1.|Extracellular (Potential).				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(4)|ovary(1)|skin(1)	6						TCTTCCAGACGACCGCCATGA	0.672000													21	6					0	0	1	0	0	
ELFN2	114794	broad.mit.edu	37	22	37769234	37769234	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:37769234G>A	uc003asq.3	-	3	3127	c.2341C>T	c.(2341-2343)CGG>TGG	p.R781W		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	781	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					ACCTCCTCCCGGTGGTGCTTC	0.602000													61	14					0	0	1	0	0	
ELFN2	114794	broad.mit.edu	37	22	37771065	37771065	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:37771065G>T	uc003asq.3	-	3	1296	c.510C>A	c.(508-510)ACC>ACA	p.T170T		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	170	LRR 5.|Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GGCTGGCAAAGGTGGCACCGT	0.647000													29	48					3.93418e-24	4.22873e-24	1	1	0	
SOX10	6663	broad.mit.edu	37	22	38373922	38373922	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:38373922G>T	uc003aun.1	-	3	927	c.649C>A	c.(649-651)CCA>ACA	p.P217T	POLR2F_uc003aum.2_Intron|SOX10_uc003auo.1_Missense_Mutation_p.P217T	NM_006941	NP_008872	P56693	SOX10_HUMAN	SRY (sex determining region Y)-box 10	217						cytoplasm|nucleus	DNA binding|identical protein binding|transcription coactivator activity				0	Melanoma(58;0.045)					CCCTCTCCTGGGTGCCGGTGG	0.687000													5	49					0.248553	0.248795	1	1	0	
KCNJ4	3761	broad.mit.edu	37	22	38824088	38824088	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:38824088C>T	uc003avs.1	-	2	147	c.50G>A	c.(49-51)CGC>CAC	p.R17H	KCNJ4_uc003avt.1_Missense_Mutation_p.R17H	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	17	Cytoplasmic (By similarity).			KR -> NG (in Ref. 3; AAC60632).	synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					GCGGTTGCGGCGCTTCCGCCG	0.642000													144	218					0	0	1	0	0	
CACNA1I	8911	broad.mit.edu	37	22	40055783	40055783	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:40055783G>A	uc003ayc.2	+	14	2530	c.2530G>A	c.(2530-2532)GCC>ACC	p.A844T	CACNA1I_uc003ayd.2_Missense_Mutation_p.A809T|CACNA1I_uc003aye.2_Missense_Mutation_p.A759T|CACNA1I_uc003ayf.2_Missense_Mutation_p.A724T	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	844	Helical; Name=S6 of repeat II; (Potential).|II.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CTACTTTGTCGCCCTCATGAC	0.582000													15	95					0	0	1	0	0	
EP300	2033	broad.mit.edu	37	22	41572350	41572350	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:41572350C>T	uc003azl.3	+	30	5274	c.4879C>T	c.(4879-4881)CGG>TGG	p.R1627W		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1627	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.R1627W(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						GATGGATGGTCGGGATGCGTT	0.577000			T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				6	111					0	0	1	0	0	
RANGAP1	5905	broad.mit.edu	37	22	41650492	41650492	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:41650492G>A	uc003azs.2	-	10	2550	c.1080C>T	c.(1078-1080)GAC>GAT	p.D360D	RANGAP1_uc003azt.2_Silent_p.D360D|RANGAP1_uc003azu.2_Silent_p.D360D|RANGAP1_uc003azr.2_5'Flank|RANGAP1_uc010gyk.2_5'Flank|RANGAP1_uc011aoz.1_Silent_p.D305D	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	360	Asp/Glu-rich (highly acidic).|Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						cctcgtcctcGTCATCACTGC	0.294000													48	69					0	0	1	0	0	
ZC3H7B	23264	broad.mit.edu	37	22	41745305	41745305	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:41745305G>T	uc003azw.2	+	16	2164	c.1948G>T	c.(1948-1950)GGC>TGC	p.G650C	ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	666					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						GCAGTACTCAGGTGAGGGGCA	0.672000													6	83					0.0293803	0.0295531	1	1	0	
PHF5A	84844	broad.mit.edu	37	22	41864625	41864625	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:41864625G>A	uc003bab.2	-	1	84	c.33C>T	c.(31-33)TGC>TGT	p.C11C	ACO2_uc003bac.2_5'Flank|ACO2_uc003bad.2_5'Flank	NM_032758	NP_116147	Q7RTV0	PHF5A_HUMAN	PHD-finger 5A	11					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent	nuclear speck|U12-type spliceosomal complex|U2 snRNP	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCTGCTTGCGGCAAAAGATCA	0.577000													41	16					0	0	1	0	0	
A4GALT	53947	broad.mit.edu	37	22	43089474	43089474	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:43089474C>T	uc003bdb.2	-	3	745	c.484G>A	c.(484-486)GTG>ATG	p.V162M	A4GALT_uc010gzd.2_Missense_Mutation_p.V162M	NM_017436	NP_059132	Q9NPC4	A4GAT_HUMAN	alpha 1,4-galactosyltransferase	162	Lumenal (Potential).				glycosphingolipid biosynthetic process|plasma membrane organization	Golgi stack|integral to Golgi membrane|membrane fraction	lactosylceramide 4-alpha-galactosyltransferase activity			central_nervous_system(2)	2						CGCCCCTGCACGGCCGCGTAC	0.657000													18	45					0	0	1	0	0	
C22orf9	23313	broad.mit.edu	37	22	45599828	45599828	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:45599828G>T	uc003bfx.1	-	6	621	c.555C>A	c.(553-555)GTC>GTA	p.V185V	C22orf9_uc010gzw.1_Silent_p.V37V|C22orf9_uc003bfv.1_Silent_p.V194V|C22orf9_uc003bfw.1_Silent_p.V190V|C22orf9_uc010gzx.2_Silent_p.V167V|MIR1249_hsa-mir-1249|MI0006384_5'Flank	NM_001009880	NP_001009880	Q6ICG6	K0930_HUMAN	hypothetical protein LOC23313 isoform b	185							protein binding				0		Ovarian(80;0.00965)|all_neural(38;0.0244)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|READ - Rectum adenocarcinoma(1;0.000617)|Colorectal(1;0.0024)		GCTCCACACAGACCATCTCTC	0.582000													5	57					5.9392e-07	6.08442e-07	1	1	0	
FAM118A	55007	broad.mit.edu	37	22	45719261	45719261	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:45719261C>T	uc003bfz.3	+	4	869	c.253C>T	c.(253-255)CGG>TGG	p.R85W	FAM118A_uc003bga.3_Missense_Mutation_p.R85W	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	85						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		GACAAAGGACCGGGACCTGTT	0.587000													23	58					0	0	1	0	0	
CELSR1	9620	broad.mit.edu	37	22	46760452	46760452	+	Silent	SNP	G	A	A	rs141928741		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:46760452G>A	uc003bhw.1	-	33	8736	c.8736C>T	c.(8734-8736)GGC>GGT	p.G2912G		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	2912	Cytoplasmic (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCCTGGCTGCGCCCCCGCTCT	0.692000													18	32					0	0	1	0	0	
SBF1	6305	broad.mit.edu	37	22	50885769	50885769	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:50885769G>A	uc003blh.2	-	40	5760	c.5565C>T	c.(5563-5565)GAC>GAT	p.D1855D	SBF1_uc003ble.2_Silent_p.D319D|SBF1_uc003blf.2_Silent_p.D331D|SBF1_uc011arx.1_Silent_p.D1493D	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1829	PH.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		AGGCCTTCTCGTCCACAGTCT	0.652000													26	47					0	0	1	0	0	
ITPR1	3708	broad.mit.edu	37	3	4859884	4859884	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:4859884C>T	uc003bqa.2	+	57	8190	c.7842C>T	c.(7840-7842)ACC>ACT	p.T2614T	ITPR1_uc010hca.1_Silent_p.T2599T|ITPR1_uc011asu.1_Silent_p.T625T|ITPR1_uc003bqc.2_Silent_p.T1584T|ITPR1_uc010hcc.1_Silent_p.T382T|ITPR1_uc011asv.1_Silent_p.T338T	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2662	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGGACTCCACCGAATATACTG	0.498000													9	23					0	0	1	0	0	
GRM7	2917	broad.mit.edu	37	3	7721813	7721813	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:7721813G>A	uc003bqm.2	+	9	2803	c.2529G>A	c.(2527-2529)CCG>CCA	p.P843P	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.P843P|GRM7_uc003bql.2_Silent_p.P843P|GRM7_uc003bqn.1_Silent_p.P426P	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	843	Helical; Name=7; (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TATACATGCCGAAAGTGTACA	0.493000													26	46					0	0	1	0	0	
SETD5	55209	broad.mit.edu	37	3	9514939	9514939	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:9514939G>A	uc003brt.2	+	20	3650	c.3215G>A	c.(3214-3216)CGA>CAA	p.R1072Q	SETD5_uc003bru.2_Missense_Mutation_p.R974Q|SETD5_uc003brv.2_Missense_Mutation_p.R961Q|SETD5_uc010hck.2_Missense_Mutation_p.R554Q|SETD5_uc003brx.2_Missense_Mutation_p.R741Q	NM_001080517	NP_001073986	Q9C0A6	SETD5_HUMAN	SET domain containing 5	1072										ovary(2)	2	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		CTGGAGTACCGAAAACGGAAA	0.463000													18	24					0	0	1	0	0	
TADA3	10474	broad.mit.edu	37	3	9832966	9832966	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:9832966C>T	uc003bsx.1	-	2	733	c.185G>A	c.(184-186)CGT>CAT	p.R62H	TADA3_uc010hcn.1_Missense_Mutation_p.R62H|TADA3_uc003bsy.2_Missense_Mutation_p.R62H|ARPC4_uc003bsz.1_5'Flank|ARPC4_uc003bta.1_5'Flank|ARPC4_uc003btb.1_5'Flank|ARPC4_uc003btc.1_5'Flank	NM_006354	NP_006345	O75528	TADA3_HUMAN	transcriptional adaptor 3 isoform a	62	Potential.				estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity				0						CTCAAGCACACGCAGGCGCCG	0.602000													18	35					0	0	1	0	0	
TTLL3	26140	broad.mit.edu	37	3	9867614	9867614	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:9867614G>A	uc003btg.2	+	8	1072	c.856G>A	c.(856-858)GCC>ACC	p.A286T	ARPC4_uc003btc.1_Intron|TTLL3_uc003btd.3_Missense_Mutation_p.A253T|TTLL3_uc003btf.3_Missense_Mutation_p.A74T|TTLL3_uc010hco.1_Missense_Mutation_p.A222T|TTLL3_uc003bth.3_Missense_Mutation_p.A74T|TTLL3_uc011atj.1_Missense_Mutation_p.A222T|TTLL3_uc003btj.3_Missense_Mutation_p.A74T|TTLL3_uc003bti.3_Missense_Mutation_p.A74T|TTLL3_uc003btk.2_Missense_Mutation_p.A89T	NM_001025930	NP_001021100	Q9Y4R7	TTLL3_HUMAN	tubulin tyrosine ligase-like family, member 3	286	TTL.				axoneme assembly|cilium assembly|protein polyglycylation	cilium axoneme|cytoplasm|microtubule	protein-glycine ligase activity, initiating|tubulin-tyrosine ligase activity			large_intestine(2)	2	Medulloblastoma(99;0.227)					GAAGCCAGGAGCCAAGTCCCG	0.522000													7	42					0	0	1	0	0	
IRAK2	3656	broad.mit.edu	37	3	10268070	10268070	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:10268070C>A	uc003bve.1	+	10	1301	c.1225C>A	c.(1225-1227)CTC>ATC	p.L409I		NM_001570	NP_001561	O43187	IRAK2_HUMAN	interleukin-1 receptor-associated kinase 2	409	Protein kinase.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB transcription factor activity|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|endosome membrane|plasma membrane	ATP binding|NF-kappaB-inducing kinase activity|protein heterodimerization activity|protein homodimerization activity			lung(5)|breast(3)	8						GGCCGAGGTCCTCACGGGCAT	0.537000													15	9					1.15088e-07	1.18493e-07	1	1	0	
HRH1	3269	broad.mit.edu	37	3	11300948	11300948	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:11300948C>T	uc010hdr.2	+	2	567	c.225C>T	c.(223-225)ATC>ATT	p.I75I	HRH1_uc010hds.2_Silent_p.I75I|HRH1_uc010hdt.2_Silent_p.I75I|HRH1_uc003bwb.3_Silent_p.I75I	NM_001098213	NP_001091683	P35367	HRH1_HUMAN	histamine receptor H1	75	Helical; Name=2; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			large_intestine(1)|ovary(1)	2					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	CGGACTTGATCGTGGGTGCCG	0.572000													42	56					0	0	1	0	0	
HDAC11	79885	broad.mit.edu	37	3	13525045	13525045	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:13525045G>A	uc003bxy.2	+	3	366	c.233G>A	c.(232-234)CGC>CAC	p.R78H	HDAC11_uc010heb.2_Missense_Mutation_p.R50H|HDAC11_uc011aux.1_Intron|HDAC11_uc003bxz.2_Missense_Mutation_p.R50H|HDAC11_uc011auy.1_Missense_Mutation_p.R50H	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	78	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						CACACGAGGCGCTATCTTAAT	0.647000													29	64					0	0	1	0	0	
FGD5	152273	broad.mit.edu	37	3	14861510	14861510	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:14861510C>T	uc003bzc.2	+	1	1042	c.932C>T	c.(931-933)ACC>ATC	p.T311I	FGD5_uc011avk.1_Missense_Mutation_p.T311I	NM_152536	NP_689749	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	311	Glu-rich.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|kidney(1)|pancreas(1)	5						GCAGCCGCCACCCTGGAGGAC	0.567000													30	49					0	0	1	0	0	
NR2C2	7182	broad.mit.edu	37	3	15062331	15062331	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:15062331A>G	uc003bzj.3	+	5	665	c.448A>G	c.(448-450)ACC>GCC	p.T150A	NR2C2_uc003bzi.2_Missense_Mutation_p.T169A	NM_003298	NP_003289	P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	150	Nuclear receptor.				cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						GAAAAATTTGACCTACAGCTG	0.448000													32	58					0	0	1	0	0	
ZFYVE20	64145	broad.mit.edu	37	3	15119589	15119589	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:15119589C>T	uc003bzm.1	-	11	1605	c.991G>A	c.(991-993)GCT>ACT	p.A331T	ZFYVE20_uc010hek.1_Missense_Mutation_p.A331T	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	331	Necessary for the interaction with RAB4A.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						TACCTTAAAGCGTCTATCAGC	0.493000													19	33					0	0	1	0	0	
ANKRD28	23243	broad.mit.edu	37	3	15737709	15737709	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:15737709G>A	uc003caj.1	-	15	1644	c.1501C>T	c.(1501-1503)CGT>TGT	p.R501C	ANKRD28_uc003cai.1_Missense_Mutation_p.R347C|ANKRD28_uc011avz.1_Missense_Mutation_p.R347C|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.R531C|ANKRD28_uc003cam.2_Missense_Mutation_p.R534C	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	501						nucleoplasm	protein binding			breast(1)	1						TGCTTATCACGGATCCCTGGA	0.383000													5	1					0	0	1	0	0	
SATB1	6304	broad.mit.edu	37	3	18393620	18393620	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:18393620T>C	uc003cbh.2	-	10	3378	c.1643A>G	c.(1642-1644)AAC>AGC	p.N548S	SATB1_uc003cbi.2_Missense_Mutation_p.N548S|SATB1_uc003cbj.2_Missense_Mutation_p.N548S	NM_002971	NP_002962	Q01826	SATB1_HUMAN	special AT-rich sequence binding protein 1	548	CUT 2.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			skin(2)|ovary(1)|lung(1)	4						CATGGAGAGGTTCTCCCACAG	0.517000													38	48					0	0	1	0	0	
TOP2B	7155	broad.mit.edu	37	3	25674015	25674015	+	Silent	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:25674015A>C	uc011awn.1	-	10	1231	c.1188T>G	c.(1186-1188)TCT>TCG	p.S396S	TOP2B_uc003cdj.2_Silent_p.S391S	NM_001068	NP_001059	Q02880	TOP2B_HUMAN	DNA topoisomerase II, beta isozyme	396					DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|resolution of meiotic recombination intermediates|sister chromatid segregation	cytosol|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex|WINAC complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						CCTTAGTCTGAGAATCAAAAG	0.318000													5	5					0	0	1	0	0	
EOMES	8320	broad.mit.edu	37	3	27759208	27759208	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:27759208C>T	uc003cdx.2	-	6	1414	c.1414G>A	c.(1414-1416)GTT>ATT	p.V472I	EOMES_uc003cdy.3_Missense_Mutation_p.V491I|EOMES_uc010hfn.2_3'UTR|EOMES_uc011axc.1_Missense_Mutation_p.V196I	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	472					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						AAGGATTGAACGCCGTACCGA	0.507000													31	62					0	0	1	0	0	
AZI2	64343	broad.mit.edu	37	3	28379465	28379465	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:28379465T>C	uc003ceb.2	-	4	934	c.402A>G	c.(400-402)GAA>GAG	p.E134E	AZI2_uc003cec.2_Silent_p.E22E|AZI2_uc003ced.2_Silent_p.E134E|AZI2_uc003cee.3_Silent_p.E134E|AZI2_uc003ceg.2_Silent_p.E134E|AZI2_uc011axd.1_Silent_p.E134E|AZI2_uc003cef.2_Silent_p.E134E	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	134	Potential.					mitochondrion|plasma membrane				ovary(2)	2						GCTGGAGGAGTTCTACTTCTT	0.328000													24	29					0	0	1	0	0	
DYNC1LI1	51143	broad.mit.edu	37	3	32568309	32568309	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:32568309C>T	uc003cfb.3	-	13	1642	c.1554G>A	c.(1552-1554)ACG>ACA	p.T518T	DYNC1LI1_uc011axh.1_Silent_p.T402T	NM_016141	NP_057225	Q9Y6G9	DC1L1_HUMAN	dynein, cytoplasmic 1, light intermediate chain	518					cell division|interspecies interaction between organisms|mitosis|positive regulation of mitotic cell cycle spindle assembly checkpoint|transport	centrosome|condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|plasma membrane|spindle pole	ATP binding|motor activity			ovary(1)	1						CTTCTCCTTCCGTAGGAGATG	0.398000													33	62					0	0	1	0	0	
ARPP21	10777	broad.mit.edu	37	3	35785437	35785437	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:35785437C>T	uc003cgb.2	+	18	2276	c.2012C>T	c.(2011-2013)CCA>CTA	p.P671L	ARPP21_uc003cga.2_Missense_Mutation_p.P652L|ARPP21_uc011axy.1_Missense_Mutation_p.P672L|ARPP21_uc003cgf.2_Missense_Mutation_p.P507L|ARPP21_uc003cgg.2_Missense_Mutation_p.P194L|uc011axz.1_5'Flank|MIR128-2_hsa-mir-128-2|MI0000727_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	671	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						CAACAGATGCCACAGGCAGCA	0.493000													41	63					0	0	1	0	0	
DCLK3	85443	broad.mit.edu	37	3	36759553	36759553	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:36759553G>T	uc003cgi.2	-	4	2192	c.1701C>A	c.(1699-1701)ATC>ATA	p.I567I		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	567	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						GGCCCAGCTGGATGATGTTAA	0.552000													61	104					1.64573e-32	1.78201e-32	1	1	0	
PLCD1	5333	broad.mit.edu	37	3	38049344	38049344	+	Missense_Mutation	SNP	G	A	A	rs142785779	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:38049344G>A	uc003chn.2	-	15	2315	c.2191C>T	c.(2191-2193)CGC>TGC	p.R731C	PLCD1_uc003chm.2_Missense_Mutation_p.R752C	NM_006225	NP_006216	P51178	PLCD1_HUMAN	phospholipase C, delta 1 isoform 2	731					intracellular signal transduction|lipid catabolic process|phospholipid metabolic process	cytoplasm	calcium ion binding|GTPase activating protein binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		TGGACATGGCGGTATCCTGGT	0.617000													9	21					0	0	1	0	0	
ULK4	54986	broad.mit.edu	37	3	41938397	41938397	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:41938397G>A	uc003ckv.3	-	15	1648	c.1447C>T	c.(1447-1449)CGA>TGA	p.R483*	ULK4_uc003ckw.2_Nonsense_Mutation_p.R483*|ULK4_uc003ckx.1_Nonsense_Mutation_p.R483*	NM_017886	NP_060356	Q96C45	ULK4_HUMAN	unc-51-like kinase 4	483							ATP binding|protein serine/threonine kinase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGCTTGGCTCGGGAGGCCCCC	0.512000													37	76					0	0	1	0	0	
NKTR	4820	broad.mit.edu	37	3	42680001	42680001	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:42680001G>A	uc003clo.2	+	13	2952	c.2805G>A	c.(2803-2805)TCG>TCA	p.S935S	NKTR_uc003clm.1_Silent_p.S682S|NKTR_uc003clp.2_Silent_p.S682S|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Silent_p.S825S|NKTR_uc003clr.1_Silent_p.S682S|NKTR_uc003cls.2_Silent_p.S635S	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	935					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CAACCAAGTCGTCCACAAATA	0.458000													22	34					0	0	1	0	0	
ANO10	55129	broad.mit.edu	37	3	43647331	43647331	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:43647331A>G	uc003cmv.2	-	2	185	c.14T>C	c.(13-15)TTA>TCA	p.L5S	ANO10_uc011azs.1_Missense_Mutation_p.L5S|ANO10_uc003cmw.2_Missense_Mutation_p.L5S|ANO10_uc010hil.2_Missense_Mutation_p.L5S|ANO10_uc011azt.1_Missense_Mutation_p.L5S	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	transmembrane protein 16K	5	Cytoplasmic (Potential).				cell death	chloride channel complex	chloride channel activity			ovary(2)	2						CAAAGCTGATAAGGTCACTTT	0.353000													8	35					0	0	1	0	0	
XCR1	2829	broad.mit.edu	37	3	46063377	46063377	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:46063377C>T	uc003cpe.2	-	3	287	c.63G>A	c.(61-63)CCG>CCA	p.P21P	uc003cpd.1_5'Flank|XCR1_uc003cpf.2_Silent_p.P21P	NM_005283	NP_005274	P46094	XCR1_HUMAN	XC chemokine receptor 1	21	Extracellular (Potential).				chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		GGTTCTCACACGGCTGGCTCT	0.552000													33	47					0	0	1	0	0	
LRRC2	79442	broad.mit.edu	37	3	46563024	46563024	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:46563024G>T	uc010hji.2	-	8	1418	c.1054C>A	c.(1054-1056)CTT>ATT	p.L352I	LRRC2_uc003cpu.3_Missense_Mutation_p.L352I	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	352										ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		CTTTCTTTAAGGTCTTCAATA	0.308000													9	14					3.09899e-07	3.18111e-07	1	1	0	
SETD2	29072	broad.mit.edu	37	3	47139450	47139450	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:47139450C>A	uc003cqs.2	-	9	5190	c.5137G>T	c.(5137-5139)GAT>TAT	p.D1713Y	SETD2_uc003cqv.2_Missense_Mutation_p.D1780Y	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1713					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CTTACTGAATCCTTCTTACGA	0.418000			N|F|S|Mis		clear cell renal carcinoma								32	55					3.11337e-16	3.31179e-16	1	1	0	
SETD2	29072	broad.mit.edu	37	3	47163427	47163427	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:47163427C>T	uc003cqs.2	-	3	2752	c.2699G>A	c.(2698-2700)TGC>TAC	p.C900Y	SETD2_uc003cqv.2_Missense_Mutation_p.C889Y	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	900					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		GTTCTCTCCGCATTTCAAGAG	0.388000			N|F|S|Mis		clear cell renal carcinoma								37	49					0	0	1	0	0	
SMARCC1	6599	broad.mit.edu	37	3	47629765	47629765	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:47629765T>C	uc003crq.2	-	28	3370	c.3252A>G	c.(3250-3252)CCA>CCG	p.P1084P	SMARCC1_uc011bbc.1_RNA|SMARCC1_uc011bbd.1_Silent_p.P975P	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	1084	Pro-rich.				chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		CAGGTGGTGGTGGCGGTGGCT	0.587000													21	28					0	0	1	0	0	
NME6	10201	broad.mit.edu	37	3	48336187	48336187	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:48336187G>A	uc003csp.3	-	6	552	c.501C>T	c.(499-501)TGC>TGT	p.C167C	NME6_uc003cso.2_Silent_p.C175C|NME6_uc011bbh.1_Missense_Mutation_p.A154V|NME6_uc010hju.2_Silent_p.C69C|NME6_uc011bbi.1_Silent_p.C100C	NM_005793	NP_005784	O75414	NDK6_HUMAN	nucleoside diphosphate kinase type 6	167					anti-apoptosis|apoptosis|CTP biosynthetic process|GTP biosynthetic process|negative regulation of cell growth|negative regulation of mitosis|UTP biosynthetic process	mitochondrion	ATP binding|metal ion binding|nucleoside diphosphate kinase activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CTGGGCTATAGCACACAGGGC	0.562000													8	86					0	0	1	0	0	
CELSR3	1951	broad.mit.edu	37	3	48682920	48682920	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:48682920C>T	uc003cul.2	-	24	8034	c.7753G>A	c.(7753-7755)GCA>ACA	p.A2585T	CELSR3_uc003cuf.1_Missense_Mutation_p.A2655T|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Missense_Mutation_p.A568T	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2585	Helical; Name=2; (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGGAGCTCTGCCACCCCCAGG	0.632000													26	51					0	0	1	0	0	
USP19	10869	broad.mit.edu	37	3	49156569	49156569	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:49156569C>T	uc003cwd.1	-	2	171	c.10G>A	c.(10-12)GGG>AGG	p.G4R	USP19_uc003cwa.2_5'Flank|USP19_uc003cvz.3_Missense_Mutation_p.G4R|USP19_uc011bcg.1_Missense_Mutation_p.G4R|USP19_uc003cwb.2_Missense_Mutation_p.G4R|USP19_uc003cwc.1_5'Flank|USP19_uc011bch.1_Missense_Mutation_p.G4R|USP19_uc011bci.1_Missense_Mutation_p.G4R	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	4	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCACTGGCCCCGCCAGACATC	0.632000													28	57					0	0	1	0	0	
LAMB2	3913	broad.mit.edu	37	3	49162267	49162267	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:49162267A>G	uc003cwe.2	-	21	3275	c.2976T>C	c.(2974-2976)ATT>ATC	p.I992I	LAMB2_uc003cwf.1_Silent_p.I992I	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	992	Laminin EGF-like 10.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCATTGGGTCAATGTTCCCAC	0.617000													7	53					0	0	1	0	0	
BSN	8927	broad.mit.edu	37	3	49698693	49698693	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:49698693C>T	uc003cxe.3	+	6	9529	c.9415C>T	c.(9415-9417)CGT>TGT	p.R3139C		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3139					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CGCTGATAGCCGTGCCCCACT	0.612000													22	43					0	0	1	0	0	
MST1	4485	broad.mit.edu	37	3	49722763	49722763	+	Silent	SNP	C	A	A	rs3882323		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:49722763C>A	uc003cxg.2	-	13	1548	c.1476G>T	c.(1474-1476)CGG>CGT	p.R492R		NM_020998	NP_066278	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth	478					proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCTTGGAACGCCGCTGATCCA	0.602000													3	39					0.150653	0.151095	1	1	0	
GMPPB	29925	broad.mit.edu	37	3	49760113	49760113	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:49760113G>A	uc003cxk.1	-	5	702	c.477C>T	c.(475-477)TTC>TTT	p.F159F	AMIGO3_uc003cxj.2_5'Flank|GMPPB_uc003cxl.1_Silent_p.F159F	NM_021971	NP_068806	Q9Y5P6	GMPPB_HUMAN	GDP-mannose pyrophosphorylase B isoform 2	159					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCTTCTCCACGAACCGGTGAA	0.572000													15	26					0	0	1	0	0	
TRAIP	10293	broad.mit.edu	37	3	49866635	49866635	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:49866635T>C	uc003cxs.1	-	15	1417	c.1311A>G	c.(1309-1311)CCA>CCG	p.P437P	TRAIP_uc010hla.1_Silent_p.P338P	NM_005879	NP_005870	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	437	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TAACAGGCAATGGGCGGATCA	0.552000													35	70					0	0	1	0	0	
CAMKV	79012	broad.mit.edu	37	3	49898957	49898957	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:49898957T>C	uc003cxt.1	-	5	549	c.356A>G	c.(355-357)GAG>GGG	p.E119G	CAMKV_uc011bcy.1_Missense_Mutation_p.E44G|CAMKV_uc003cxv.1_Missense_Mutation_p.E119G|CAMKV_uc003cxw.1_5'UTR|CAMKV_uc003cxx.1_5'UTR|CAMKV_uc003cxu.2_Missense_Mutation_p.E119G|CAMKV_uc011bcz.1_Missense_Mutation_p.E82G|CAMKV_uc011bda.1_Intron|CAMKV_uc011bdb.1_RNA	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	119	Protein kinase.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TGTGTCTCGCTCCGAGTAGTA	0.607000													5	67					0	0	1	0	0	
ZMYND10	51364	broad.mit.edu	37	3	50381254	50381254	+	Missense_Mutation	SNP	C	T	T	rs146847253	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:50381254C>T	uc003dag.1	-	3	375	c.229G>A	c.(229-231)GCA>ACA	p.A77T	RASSF1_uc003dad.1_5'Flank|RASSF1_uc003dae.1_5'Flank|RASSF1_uc010hlk.1_5'Flank|RASSF1_uc003daf.1_5'Flank|RASSF1_uc011bdq.1_5'Flank|ZMYND10_uc010hll.1_Missense_Mutation_p.A77T|ZMYND10_uc003dah.1_5'UTR|ZMYND10_uc010hlm.1_Missense_Mutation_p.A34T	NM_015896	NP_056980	O75800	ZMY10_HUMAN	zinc finger, MYND domain-containing 10	77						cytoplasm	protein binding|zinc ion binding			lung(4)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		ATCTCCACTGCGATCAGCTCC	0.582000										TSP Lung(30;0.18)			27	50					0	0	1	0	0	
RBM15B	29890	broad.mit.edu	37	3	51429992	51429992	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:51429992G>T	uc003dbd.2	+	1	1262	c.1162G>T	c.(1162-1164)GAC>TAC	p.D388Y		NM_013286	NP_037418	Q8NDT2	RB15B_HUMAN	RNA binding motif protein 15B	388	RRM 2.				interspecies interaction between organisms|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleoplasm	nucleotide binding|protein binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000224)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCAGAACCTGGACATGGCCCA	0.582000													19	28					8.28177e-16	8.7959e-16	1	1	0	
VPRBP	9730	broad.mit.edu	37	3	51475715	51475715	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:51475715C>T	uc003dbe.1	-	8	880	c.712G>A	c.(712-714)GAG>AAG	p.E238K	VPRBP_uc003dbg.1_Missense_Mutation_p.E238K	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	238					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		AAGGAGATCTCCATGTCTCCA	0.463000													104	145					0	0	1	0	0	
RAD54L2	23132	broad.mit.edu	37	3	51677945	51677945	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:51677945A>G	uc011bdt.1	+	15	2530	c.2405A>G	c.(2404-2406)AAT>AGT	p.N802S	RAD54L2_uc003dbh.2_Missense_Mutation_p.N391S|RAD54L2_uc011bdu.1_Missense_Mutation_p.N496S|RAD54L2_uc003dbj.2_Missense_Mutation_p.N128S	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	802	Helicase C-terminal.					nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		AATCAGTTCAATGATCCCAGC	0.507000													5	12					0	0	1	0	0	
RAD54L2	23132	broad.mit.edu	37	3	51680401	51680401	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:51680401G>A	uc011bdt.1	+	18	3055	c.2930G>A	c.(2929-2931)CGC>CAC	p.R977H	RAD54L2_uc003dbh.2_Missense_Mutation_p.R566H|RAD54L2_uc011bdu.1_Missense_Mutation_p.R671H|RAD54L2_uc003dbj.2_Missense_Mutation_p.R303H	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	977						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GAAGACAAACGCACATCAGTC	0.512000													12	7					0	0	1	0	0	
TLR9	54106	broad.mit.edu	37	3	52255992	52255992	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:52255992G>A	uc003dda.1	-	2	2974	c.2340C>T	c.(2338-2340)GCC>GCT	p.A780A	TLR9_uc003ddb.2_Silent_p.A877A	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	780	Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GACCGGGCACGGCAGCCTGCA	0.657000													15	18					0	0	1	0	0	
PPM1M	132160	broad.mit.edu	37	3	52281754	52281754	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:52281754C>A	uc003ddf.3	+	4	536	c.171C>A	c.(169-171)GCC>GCA	p.A57A	PPM1M_uc011bed.1_Silent_p.A218A|PPM1M_uc010hmd.2_Silent_p.A57A|PPM1M_uc003ddg.3_Silent_p.A6A|PPM1M_uc003ddh.3_5'Flank			Q96MI6	PPM1M_HUMAN	RecName: Full=Protein phosphatase 1M;          EC=3.1.3.16; AltName: Full=Protein phosphatase 2C isoform eta;          Short=PP2C-eta;          Short=PP2CE;	57	PP2C-like.				protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding				0				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		GCTGCACAGCCCTGGTGGCTG	0.647000													8	5					1.12685e-05	1.15096e-05	1	1	0	
DNAH1	25981	broad.mit.edu	37	3	52393996	52393996	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:52393996C>T	uc011bef.1	+	27	4733	c.4472C>T	c.(4471-4473)GCG>GTG	p.A1491V		NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1491	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTGCTGTCAGCGCTAATCGTC	0.567000													48	88					0	0	1	0	0	
STAB1	23166	broad.mit.edu	37	3	52555418	52555418	+	Missense_Mutation	SNP	G	A	A	rs142954501		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:52555418G>A	uc003dej.2	+	56	6024	c.5950G>A	c.(5950-5952)GTG>ATG	p.V1984M	STAB1_uc003dek.1_Translation_Start_Site|STAB1_uc003del.2_Translation_Start_Site	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1984	Extracellular (Potential).|Laminin EGF-like 2.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TGACCGTGGCGTGTGCATGGA	0.637000													36	62					0	0	1	0	0	
SPCS1	28972	broad.mit.edu	37	3	52740858	52740858	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:52740858T>G	uc011bei.1	+	3	552	c.347T>G	c.(346-348)GTC>GGC	p.V116G	GLT8D1_uc003dfj.2_5'Flank|GLT8D1_uc003dfk.2_5'Flank|GLT8D1_uc003dfl.2_5'Flank|GLT8D1_uc003dfm.2_5'Flank|GLT8D1_uc003dfn.2_5'Flank|GLT8D1_uc003dfo.1_5'Flank|GLT8D1_uc010hmm.1_5'Flank	NM_014041	NP_054760	Q9Y6A9	SPCS1_HUMAN	signal peptidase complex subunit 1 homolog	116	Helical; (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to endoplasmic reticulum membrane|microsome|signal peptidase complex	peptidase activity				0				BRCA - Breast invasive adenocarcinoma(193;6.51e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)|OV - Ovarian serous cystadenocarcinoma(275;0.0469)		GGGTGGACTGTCTATATAGTT	0.428000													91	124					0	0	1	0	0	
CACNA1D	776	broad.mit.edu	37	3	53700370	53700370	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:53700370C>T	uc003dgv.3	+	7	1087	c.924C>T	c.(922-924)ATC>ATT	p.I308I	CACNA1D_uc003dgu.3_Silent_p.I308I|CACNA1D_uc003dgy.3_Silent_p.I308I|CACNA1D_uc003dgw.3_5'UTR	NM_001128840	NP_001122312	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type,	308	Extracellular (Potential).|I.				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(6)|upper_aerodigestive_tract(2)|liver(1)|central_nervous_system(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	TTGCAGATATCGTAGCTGAAG	0.567000													67	84					0	0	1	0	0	
LRTM1	57408	broad.mit.edu	37	3	54952736	54952736	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:54952736G>A	uc003dhl.2	-	3	922	c.788C>T	c.(787-789)GCG>GTG	p.A263V	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	263	Extracellular (Potential).					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		TCGCTCCCCCGCGTTGTGGTT	0.627000													14	30					0	0	1	0	0	
ASB14	142686	broad.mit.edu	37	3	57312678	57312678	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:57312678C>T	uc003diq.2	-	8	1254	c.666G>A	c.(664-666)CCG>CCA	p.P222P	ASB14_uc003dip.1_Silent_p.P101P	NM_001142733	NP_001136205	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box-containing 14	386	ANK 10.				intracellular signal transduction						0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		GGCAGTTAACCGGGTCTTGAT	0.488000													7	57					0	0	1	0	0	
PRICKLE2	166336	broad.mit.edu	37	3	64133162	64133162	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:64133162C>T	uc003dmf.2	-	7	1590	c.1004G>A	c.(1003-1005)CGG>CAG	p.R335Q		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	335						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GGCACTGCGCCGGGACTCCTT	0.597000													65	111					0	0	1	0	0	
ADAMTS9	56999	broad.mit.edu	37	3	64672445	64672445	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:64672445G>A	uc003dmg.2	-	2	347	c.315C>T	c.(313-315)TTC>TTT	p.F105F	ADAMTS9_uc011bfo.1_Silent_p.F105F|ADAMTS9_uc003dmh.1_5'UTR|ADAMTS9_uc003dmk.1_Silent_p.F105F|uc003dml.2_Intron	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	105					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		ACTGCTGGCCGAAGGCAGAGA	0.502000													15	24					0	0	1	0	0	
KBTBD8	84541	broad.mit.edu	37	3	67049611	67049611	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:67049611T>C	uc003dmy.2	+	2	276	c.223T>C	c.(223-225)TTC>CTC	p.F75L	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	75	BTB.									ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		CAGCCCTTACTTCAGGTATGA	0.428000													49	89					0	0	1	0	0	
FAM19A4	151647	broad.mit.edu	37	3	68782295	68782295	+	Nonstop_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:68782295A>G	uc003dnh.1	-	6	864	c.421T>C	c.(421-423)TAG>CAG	p.*141Q	FAM19A4_uc003dni.1_Nonstop_Mutation_p.*141Q	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine	141						extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TCTCTTCGCTACCGCGTTACC	0.493000													40	55					0	0	1	0	0	
TMF1	7110	broad.mit.edu	37	3	69097100	69097100	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:69097100A>G	uc003dnn.2	-	2	1003	c.756T>C	c.(754-756)GGT>GGC	p.G252G	TMF1_uc011bfx.1_Silent_p.G252G	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	252					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		TGGTAGAAGTACCTGATGAAA	0.408000													31	31					0	0	1	0	0	
CNTN3	5067	broad.mit.edu	37	3	74334537	74334537	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:74334537A>G	uc003dpm.1	-	19	2703	c.2623T>C	c.(2623-2625)TAT>CAT	p.Y875H		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	875	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GCCGTGTAATAGGCCAGGTTG	0.507000													73	105					0	0	1	0	0	
ROBO1	6091	broad.mit.edu	37	3	78737895	78737895	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:78737895C>T	uc003dqe.2	-	9	1281	c.1073G>A	c.(1072-1074)CGT>CAT	p.R358H	ROBO1_uc003dqb.2_Missense_Mutation_p.R319H|ROBO1_uc003dqc.2_Missense_Mutation_p.R322H|ROBO1_uc003dqd.2_Missense_Mutation_p.R322H|ROBO1_uc010hoh.2_Translation_Start_Site|ROBO1_uc003dqf.1_Missense_Mutation_p.R37H	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	358	Extracellular (Potential).|Ig-like C2-type 4.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AACCTGGTCACGGGGTTTCAC	0.428000													9	12					0	0	1	0	0	
ROBO1	6091	broad.mit.edu	37	3	78796030	78796030	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:78796030G>A	uc003dqe.2	-	5	728	c.520C>T	c.(520-522)CAA>TAA	p.Q174*	ROBO1_uc003dqb.2_Nonsense_Mutation_p.Q135*|ROBO1_uc003dqc.2_Nonsense_Mutation_p.Q135*|ROBO1_uc003dqd.2_Nonsense_Mutation_p.Q135*	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	174	Extracellular (Potential).|Ig-like C2-type 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GAAGGGTTTTGTCTGAAGTCA	0.443000													12	24					0	0	1	0	0	
PROS1	5627	broad.mit.edu	37	3	93593131	93593131	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:93593131A>G	uc003drb.3	-	15	2330	c.1989T>C	c.(1987-1989)GCT>GCC	p.A663A	PROS1_uc010hoo.2_Silent_p.A532A|PROS1_uc003dqz.3_Silent_p.A532A	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	663	Laminin G-like 2.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	GACATGAGTGAGCTCTAATAT	0.343000													22	31					0	0	1	0	0	
CLDND1	56650	broad.mit.edu	37	3	98235544	98235544	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:98235544G>A	uc003dsp.2	-	5	1601	c.721C>T	c.(721-723)CGG>TGG	p.R241W	CLDND1_uc003dso.2_Intron|CLDND1_uc003dsq.2_Missense_Mutation_p.R241W|CLDND1_uc003dss.2_Missense_Mutation_p.R241W|CLDND1_uc003dsr.2_Missense_Mutation_p.R146W|CLDND1_uc003dst.2_Missense_Mutation_p.R264W|CLDND1_uc003dsu.2_Missense_Mutation_p.R241W|CLDND1_uc003dsv.2_Missense_Mutation_p.R241W	NM_019895	NP_063948	Q9NY35	CLDN1_HUMAN	claudin domain containing 1 protein isoform a	241						integral to membrane				ovary(1)	1						TACTCTTTCCGGTTGGTGTGA	0.428000													26	44					0	0	1	0	0	
GPR15	2838	broad.mit.edu	37	3	98251047	98251047	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:98251047C>T	uc011bgy.1	+	1	170	c.170C>T	c.(169-171)GCG>GTG	p.A57V		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	57	Cytoplasmic (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CTCATGGGAGCGTTGCATTTC	0.498000													24	33					0	0	1	0	0	
CPOX	1371	broad.mit.edu	37	3	98300252	98300252	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:98300252G>A	uc003dsx.2	-	6	1369	c.1276C>T	c.(1276-1278)CGA>TGA	p.R426*		NM_000097	NP_000088	P36551	HEM6_HUMAN	coproporphyrinogen oxidase precursor	426	Important for dimerization.					mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity				0						TCTCCTTACCGGGCAGTTAGA	0.413000													19	39					0	0	1	0	0	
TOMM70A	9868	broad.mit.edu	37	3	100096645	100096645	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:100096645C>T	uc003dtw.2	-	6	1428	c.996G>A	c.(994-996)TTG>TTA	p.L332L		NM_014820	NP_055635	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70	332	Cytoplasmic (Potential).|TPR 4.				protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			ovary(1)	1						CTCGTAGTAGCAATGCTTCTG	0.378000													30	49					0	0	1	0	0	
BOC	91653	broad.mit.edu	37	3	112998720	112998720	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:112998720C>T	uc003dzx.2	+	13	2691	c.2070C>T	c.(2068-2070)AGC>AGT	p.S690S	BOC_uc003dzy.2_Silent_p.S690S|BOC_uc003dzz.2_Silent_p.S691S|BOC_uc003eab.2_Silent_p.S391S|BOC_uc003eac.2_Silent_p.S5S	NM_033254	NP_150279	Q9BWV1	BOC_HUMAN	brother of CDO precursor	690	Fibronectin type-III 2.|Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|pancreas(1)	6			Epithelial(53;0.227)			TGGGGGAGAGCGAGCCCAGCG	0.612000													38	77					0	0	1	0	0	
DRD3	1814	broad.mit.edu	37	3	113878640	113878640	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:113878640T>C	uc003ebd.2	-	4	768	c.345A>G	c.(343-345)ACA>ACG	p.T115T	DRD3_uc010hqn.1_Silent_p.T115T|DRD3_uc003ebb.1_Silent_p.T115T|DRD3_uc003ebc.1_Silent_p.T115T	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	115	Helical; Name=3.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GGATGCTGGCTGTACACATCA	0.507000													36	56					0	0	1	0	0	
POLQ	10721	broad.mit.edu	37	3	121251977	121251977	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:121251977C>T	uc003eee.3	-	6	949	c.820G>A	c.(820-822)GTG>ATG	p.V274M		NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	274	Helicase ATP-binding.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CAGGAAGCCACAAGCTCCAAA	0.423000								DNA_polymerases_(catalytic_subunits)					25	48					0	0	1	0	0	
CASR	846	broad.mit.edu	37	3	121980530	121980530	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:121980530C>T	uc003eev.3	+	4	1020	c.648C>T	c.(646-648)GAC>GAT	p.D216D	CASR_uc003eew.3_Silent_p.D216D	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	216	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CAGCTGATGACGACTATGGGC	0.537000													60	93					0	0	1	0	0	
ALDH1L1	10840	broad.mit.edu	37	3	125850310	125850310	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:125850310C>T	uc003eim.1	-	13	1730	c.1540G>A	c.(1540-1542)GTC>ATC	p.V514I	ALDH1L1_uc010hse.1_Intron|ALDH1L1_uc011bki.1_Missense_Mutation_p.V413I|ALDH1L1_uc003eio.2_Missense_Mutation_p.V216I	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	514	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	AGCGTGTAGACGGCACCCGCA	0.642000													34	56					0	0	1	0	0	
PLXNA1	5361	broad.mit.edu	37	3	126740964	126740964	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:126740964G>A	uc003ejg.2	+	21	4010	c.4006G>A	c.(4006-4008)GGG>AGG	p.G1336R		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1359	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GACACTGTTCGGGCAGCTGCT	0.627000													13	23					0	0	1	0	0	
PODXL2	50512	broad.mit.edu	37	3	127358266	127358266	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:127358266C>T	uc003ejq.2	+	2	273	c.249C>T	c.(247-249)AGC>AGT	p.S83S		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	83	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						GCTTCCCCAGCGAAGAGAATG	0.602000													19	35					0	0	1	0	0	
ABTB1	80325	broad.mit.edu	37	3	127399266	127399266	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:127399266A>G	uc003ejt.2	+	12	1473	c.1385A>G	c.(1384-1386)CAG>CGG	p.Q462R	ABTB1_uc003ejr.2_Missense_Mutation_p.Q320R|ABTB1_uc003ejs.2_Missense_Mutation_p.Q437R|ABTB1_uc003eju.2_Missense_Mutation_p.Q320R|ABTB1_uc010hsm.2_Missense_Mutation_p.Q189R	NM_172027	NP_742024	Q969K4	ABTB1_HUMAN	ankyrin repeat and BTB (POZ) domain containing 1	462	Potential.					cytoplasm|nucleolus|plasma membrane	translation elongation factor activity				0						GAGGCGCAGCAGCGTCTGCGG	0.667000													8	7					0	0	1	0	0	
EEFSEC	60678	broad.mit.edu	37	3	127965713	127965713	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:127965713C>T	uc003eki.2	+	2	389	c.351C>T	c.(349-351)ATC>ATT	p.I117I	EEFSEC_uc003ekj.2_Silent_p.I117I	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	117						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						TGCTGGTCATCGATGTGACCA	0.522000													72	136					0	0	1	0	0	
GATA2	2624	broad.mit.edu	37	3	128204753	128204753	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:128204753G>A	uc003ekm.3	-	4	1123	c.688C>T	c.(688-690)CGC>TGC	p.R230C	GATA2_uc003ekn.3_Missense_Mutation_p.R230C|GATA2_uc003eko.2_Missense_Mutation_p.R230C	NM_001145661	NP_001139133	P23769	GATA2_HUMAN	GATA binding protein 2 isoform 1	230					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(13)|lung(1)|skin(1)	15				GBM - Glioblastoma multiforme(114;0.173)		AGGCCTGGGCGCAGGGGACTG	0.642000			Mis		AML(CML blast transformation)								18	29					0	0	1	0	0	
ASTE1	28990	broad.mit.edu	37	3	130743281	130743281	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:130743281T>C	uc003env.1	-	3	1312	c.870A>G	c.(868-870)GAA>GAG	p.E290E	NEK11_uc003enx.2_5'Flank|NEK11_uc003eny.2_5'Flank|NEK11_uc003eoa.2_5'Flank|NEK11_uc003enz.2_5'Flank|NEK11_uc010htn.2_5'Flank|NEK11_uc011blk.1_5'Flank|NEK11_uc011bll.1_5'Flank|NEK11_uc003enw.1_5'Flank|NEK11_uc011blm.1_5'Flank|ASTE1_uc010htm.1_Silent_p.E290E|ASTE1_uc011blj.1_RNA	NM_014065	NP_054784	Q2TB18	ASTE1_HUMAN	asteroid homolog 1	290					DNA repair		nuclease activity				0						AGCAGAGAAGTTCCTTAACAT	0.433000													26	54					0	0	1	0	0	
DNAJC13	23317	broad.mit.edu	37	3	132175582	132175582	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:132175582G>A	uc003eor.2	+	12	1320	c.1255G>A	c.(1255-1257)GTT>ATT	p.V419I	DNAJC13_uc010htq.1_Missense_Mutation_p.V419I|DNAJC13_uc003eos.1_Missense_Mutation_p.V86I	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	419							heat shock protein binding			ovary(1)|breast(1)	2						AGGGGATGTCGTTGCTTCAAA	0.438000													28	62					0	0	1	0	0	
PPP2R3A	5523	broad.mit.edu	37	3	135722322	135722322	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:135722322C>T	uc003eqv.1	+	2	2547	c.1982C>T	c.(1981-1983)CCA>CTA	p.P661L	PPP2R3A_uc011blz.1_Intron	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'',	661					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			ovary(3)|pancreas(1)|lung(1)|breast(1)|skin(1)	7						CAGCAGACTCCAGAGGTGATC	0.363000													25	62					0	0	1	0	0	
PRR23B	389151	broad.mit.edu	37	3	138738987	138738987	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:138738987C>T	uc003esy.1	-	1	782	c.517G>A	c.(517-519)GGC>AGC	p.G173S		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	173										breast(1)	1						GCGGCTGAGCCGGTTGGGGAG	0.652000													30	47					0	0	1	0	0	
ZBTB38	253461	broad.mit.edu	37	3	141163979	141163979	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:141163979C>T	uc003etw.2	+	8	3731	c.2749C>T	c.(2749-2751)CGC>TGC	p.R917C	ZBTB38_uc010hun.2_Missense_Mutation_p.R914C|ZBTB38_uc010huo.2_Missense_Mutation_p.R917C|ZBTB38_uc003ety.2_Missense_Mutation_p.R917C|ZBTB38_uc010hup.2_Missense_Mutation_p.R918C	NM_001080412	NP_001073881	Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	917					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CAAACCGTGGCGCCCTTACTA	0.507000													15	29					0	0	1	0	0	
CHST2	9435	broad.mit.edu	37	3	142840163	142840163	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:142840163G>A	uc003evm.2	+	2	1394	c.505G>A	c.(505-507)GTG>ATG	p.V169M		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	169	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						GCTGGTGTACGTGTTCACCAC	0.652000													11	18					0	0	1	0	0	
CLRN1	7401	broad.mit.edu	37	3	150645745	150645745	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:150645745A>G	uc003eyk.1	-	3	968	c.677T>C	c.(676-678)GTA>GCA	p.V226A	CLRN1OS_uc011bny.1_Intron|CLRN1_uc003eyj.2_Intron	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	226					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			ATCTGCAGCTACATTAGTTGT	0.358000													29	42					0	0	1	0	0	
IGSF10	285313	broad.mit.edu	37	3	151154554	151154554	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:151154554C>T	uc011bod.1	-	6	7795	c.7795G>A	c.(7795-7797)GAT>AAT	p.D2599N	IGSF10_uc011bob.1_Missense_Mutation_p.D626N|IGSF10_uc011boc.1_Missense_Mutation_p.D578N	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2599	Ig-like C2-type 12.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATCCCAGAATCGGAGGTTTGG	0.423000													47	80					0	0	1	0	0	
IGSF10	285313	broad.mit.edu	37	3	151164291	151164291	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:151164291C>T	uc011bod.1	-	4	3478	c.3478G>A	c.(3478-3480)GCC>ACC	p.A1160T		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1160					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGGTAACTGGCGTTTACTTTG	0.413000													116	200					0	0	1	0	0	
SCHIP1	29970	broad.mit.edu	37	3	159583997	159583997	+	Nonsense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:159583997G>T	uc003fcs.1	+	3	871	c.805G>T	c.(805-807)GGA>TGA	p.G269*	SCHIP1_uc003fcq.1_Nonsense_Mutation_p.G345*|SCHIP1_uc003fcr.1_Nonsense_Mutation_p.G258*|SCHIP1_uc003fct.1_Nonsense_Mutation_p.G256*|SCHIP1_uc010hvz.1_Nonsense_Mutation_p.G229*|SCHIP1_uc003fcu.1_Nonsense_Mutation_p.G26*|SCHIP1_uc003fcv.1_Nonsense_Mutation_p.G42*	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	269						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			GTTGGCACTTGGAAGCTTCTT	0.408000													50	85					1.83081e-24	1.96891e-24	1	1	0	
SMC4	10051	broad.mit.edu	37	3	160141239	160141239	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:160141239C>T	uc003fdh.2	+	14	2159	c.2046C>T	c.(2044-2046)ACC>ACT	p.T682T	IFT80_uc003fda.2_Intron|SMC4_uc010hwc.1_Silent_p.T446T|SMC4_uc003fdi.2_Silent_p.T657T|SMC4_uc003fdj.2_Silent_p.T682T|SMC4_uc010hwd.2_Silent_p.T682T|SMC4_uc003fdl.2_Silent_p.T385T	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	682	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAAAGATGACCGAAATTCAAA	0.279000													45	53					0	0	1	0	0	
SMC4	10051	broad.mit.edu	37	3	160150302	160150302	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:160150302A>G	uc003fdh.2	+	22	3642	c.3529A>G	c.(3529-3531)AGT>GGT	p.S1177G	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.S1152G|SMC4_uc003fdj.2_Missense_Mutation_p.S1177G|SMC4_uc010hwd.2_Missense_Mutation_p.S1119G|SMC4_uc003fdl.2_Missense_Mutation_p.S880G	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1177					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AATCATGTTCAGGTGTGTAAT	0.388000													7	11					0	0	1	0	0	
WDR49	151790	broad.mit.edu	37	3	167249049	167249049	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:167249049A>G	uc003fev.1	-	9	1322	c.1016T>C	c.(1015-1017)CTT>CCT	p.L339P	WDR49_uc003feu.1_Missense_Mutation_p.L164P|WDR49_uc011bpd.1_Missense_Mutation_p.L403P|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	339										large_intestine(1)|ovary(1)|skin(1)	3						AGCACTGAGAAGTTTTTGAGG	0.448000													34	49					0	0	1	0	0	
TNFSF10	8743	broad.mit.edu	37	3	172241171	172241171	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:172241171C>A	uc003fid.2	-	1	99	c.4G>T	c.(4-6)GCT>TCT	p.A2S	TNFSF10_uc003fie.2_Missense_Mutation_p.A2S|TNFSF10_uc010hwu.1_RNA	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	2	Cytoplasmic (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TCCATCATAGCCATGATCCTG	0.527000													28	57					2.65835e-16	2.8307e-16	1	1	0	
NCEH1	57552	broad.mit.edu	37	3	172351781	172351781	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:172351781A>G	uc011bpx.1	-	5	969	c.831T>C	c.(829-831)AAT>AAC	p.N277N	NCEH1_uc003fig.2_Silent_p.N269N|NCEH1_uc011bpw.1_Silent_p.N104N|NCEH1_uc011bpy.1_Silent_p.N104N	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	237	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						GGGTGTTCACATTTTGCTGAT	0.393000													29	43					0	0	1	0	0	
ACTL6A	86	broad.mit.edu	37	3	179298752	179298752	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:179298752C>T	uc003fjw.2	+	10	1074	c.901C>T	c.(901-903)CGG>TGG	p.R301W	ACTL6A_uc003fjx.2_Missense_Mutation_p.R259W|ACTL6A_uc003fjy.2_Missense_Mutation_p.R259W	NM_004301	NP_004292	O96019	ACL6A_HUMAN	actin-like 6A isoform 1	301					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			ovary(1)	1	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			TGGTGCAGAGCGGCTAAAGAT	0.368000													46	80					0	0	1	0	0	
LAMP3	27074	broad.mit.edu	37	3	182870248	182870248	+	Missense_Mutation	SNP	G	A	A	rs151059567	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:182870248G>A	uc003flh.3	-	3	1027	c.803C>T	c.(802-804)ACG>ATG	p.T268M		NM_014398	NP_055213	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	268	Lumenal (Potential).				cell proliferation	integral to membrane|lysosomal membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			AGAGGCTTGCGTTGCGTTGGG	0.458000													107	168					0	0	1	0	0	
MCF2L2	23101	broad.mit.edu	37	3	183035921	183035921	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:183035921G>A	uc003fli.1	-	7	778	c.688C>T	c.(688-690)CCC>TCC	p.P230S	MCF2L2_uc003flj.1_Missense_Mutation_p.P230S|MCF2L2_uc003flp.1_Missense_Mutation_p.P265S	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	230					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ATGCTTCTGGGCAGCTCTGCT	0.572000													14	27					0	0	1	0	0	
ABCC5	10057	broad.mit.edu	37	3	183665239	183665239	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:183665239C>T	uc003fmg.2	-	23	3452	c.3287G>A	c.(3286-3288)CGG>CAG	p.R1096Q	ABCC5_uc011bqt.1_Missense_Mutation_p.R624Q|ABCC5_uc010hxl.2_Missense_Mutation_p.R1053Q	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	1096	ABC transmembrane type-1 2.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGCCAGCCACCGCATCGCACA	0.527000													14	16					0	0	1	0	0	
DVL3	1857	broad.mit.edu	37	3	183885455	183885455	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:183885455G>A	uc003fms.2	+	12	1426	c.1286G>A	c.(1285-1287)CGT>CAT	p.R429H	DVL3_uc011bqw.1_Missense_Mutation_p.R412H|DVL3_uc003fmt.2_Missense_Mutation_p.R100H|DVL3_uc003fmu.2_Missense_Mutation_p.R261H	NM_004423	NP_004414	Q92997	DVL3_HUMAN	dishevelled 3	429	DEP.				canonical Wnt receptor signaling pathway|intracellular signal transduction|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent	cytoplasm	beta-catenin binding|frizzled binding|protease binding|protein heterodimerization activity|signal transducer activity			ovary(1)|lung(1)|breast(1)	3	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.08e-34)|OV - Ovarian serous cystadenocarcinoma(80;1.31e-22)			TTGGAGGTCCGTGACCGCATG	0.572000													20	43					0	0	1	0	0	
PSMD2	5708	broad.mit.edu	37	3	184018118	184018118	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:184018118G>C	uc003fnn.1	+	3	276	c.243G>C	c.(241-243)CAG>CAC	p.Q81H	PSMD2_uc011brj.1_5'Flank|PSMD2_uc011brk.1_5'Flank	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	81					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	TGCGAAGGCAGATTCGTTCTT	0.488000													30	44					0	0	1	0	0	
RTP1	132112	broad.mit.edu	37	3	186915363	186915363	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:186915363C>T	uc003frg.2	+	1	90	c.60C>T	c.(58-60)TCC>TCT	p.S20S		NM_153708	NP_714919	P59025	RTP1_HUMAN	receptor transporting protein 1	20	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			ovary(2)|breast(1)	3	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CCTCACTCTCCGTGTTCTCAC	0.522000													37	65					0	0	1	0	0	
RTP2	344892	broad.mit.edu	37	3	187416477	187416477	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:187416477C>T	uc003fro.1	-	2	916	c.487G>A	c.(487-489)GTT>ATT	p.V163I		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	163	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		TTCCAGTGAACGATGCCCTCC	0.652000													21	38					0	0	1	0	0	
TPRG1	285386	broad.mit.edu	37	3	189038590	189038590	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:189038590G>A	uc003frv.1	+	11	2036	c.809G>A	c.(808-810)CGT>CAT	p.R270H	TPRG1_uc003frw.1_Missense_Mutation_p.R270H	NM_198485	NP_940887	Q6ZUI0	TPRG1_HUMAN	tumor protein p63 regulated 1	270											0	all_cancers(143;6.12e-12)|all_hematologic(3;0.0359)|Ovarian(172;0.0925)	all_lung(153;8.23e-09)|Lung NSC(153;3.55e-06)|all_neural(597;0.0019)|Myeloproliferative disorder(1037;0.0255)	Lung(62;6.93e-06)	GBM - Glioblastoma multiforme(93;4.77e-14)		TCCCTTGCCCGTGGGAGTATT	0.413000													10	22					0	0	1	0	0	
CCDC50	152137	broad.mit.edu	37	3	191087798	191087798	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:191087798G>A	uc003fsw.2	+	5	1011	c.421G>A	c.(421-423)GCA>ACA	p.A141T	CCDC50_uc003fsv.2_Missense_Mutation_p.A141T	NM_174908	NP_777568	Q8IVM0	CCD50_HUMAN	Ymer protein short isoform	141						cytoplasm	protein binding				0	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		CCGTGCTTATGCAGATAGTTA	0.383000													48	97					0	0	1	0	0	
C3orf59	151963	broad.mit.edu	37	3	192516769	192516769	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:192516769G>A	uc011bsp.1	-	2	1203	c.882C>T	c.(880-882)AGC>AGT	p.S294S		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	294											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		ACTGCACCTCGCTCCTGGCAA	0.517000													16	25					0	0	1	0	0	
OPA1	4976	broad.mit.edu	37	3	193336664	193336664	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:193336664C>T	uc003ftm.2	+	5	797	c.563C>T	c.(562-564)CCG>CTG	p.P188L	OPA1_uc003ftg.2_Missense_Mutation_p.P206L|OPA1_uc003fth.2_Missense_Mutation_p.P170L|OPA1_uc003fti.2_Missense_Mutation_p.P188L|OPA1_uc003ftj.2_Missense_Mutation_p.P206L|OPA1_uc003ftk.2_Missense_Mutation_p.P152L|OPA1_uc003ftl.2_Missense_Mutation_p.P170L|OPA1_uc003ftn.2_Missense_Mutation_p.P152L	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	188	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TAAGGTTCTCCGGAAGAAACG	0.378000													36	71					0	0	1	0	0	
ACAP2	23527	broad.mit.edu	37	3	195013108	195013108	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:195013108C>T	uc003fun.3	-	19	2080	c.1839G>A	c.(1837-1839)GCG>GCA	p.A613A		NM_012287	NP_036419	Q15057	ACAP2_HUMAN	centaurin, beta 2	613					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)	2						TTTCATATGACGCCCTATAAA	0.413000													43	69					0	0	1	0	0	
SDHAP1	255812	broad.mit.edu	37	3	195701373	195701373	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:195701373G>A	uc011btq.1	-	8	1120	c.491C>T	c.(490-492)GCC>GTC	p.A164V	SDHAP1_uc003fvx.3_RNA|SDHAP1_uc011btp.1_RNA					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						AGAGGCACAGGCGGCCTCCCC	0.587000													15	122					0	0	1	0	0	
RNF168	165918	broad.mit.edu	37	3	196229935	196229935	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:196229935T>C	uc003fwq.2	-	1	648	c.110A>G	c.(109-111)AAA>AGA	p.K37R	RNF168_uc010iah.2_5'UTR	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	37	RING-type.				double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GAAGCACGGTTTACACAGCGT	0.587000													34	59					0	0	1	0	0	
LRRC33	375387	broad.mit.edu	37	3	196386950	196386950	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:196386950G>A	uc003fwv.2	+	3	540	c.436G>A	c.(436-438)GAG>AAG	p.E146K		NM_198565	NP_940967	Q86YC3	LRC33_HUMAN	leucine rich repeat containing 33 precursor	146	Extracellular (Potential).|LRR 4.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.9e-23)|all cancers(36;1.76e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00326)		CGCCCTGACGGAGGACATGGC	0.662000													12	25					0	0	1	0	0	
DLG1	1739	broad.mit.edu	37	3	196792302	196792302	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:196792302G>A	uc003fxo.3	-	23	2441	c.2251C>T	c.(2251-2253)CGA>TGA	p.R751*	DLG1_uc011bub.1_Nonsense_Mutation_p.R647*|DLG1_uc011buc.1_Nonsense_Mutation_p.R635*|DLG1_uc011bud.1_Nonsense_Mutation_p.R434*|DLG1_uc003fxn.3_Nonsense_Mutation_p.R773*|DLG1_uc011bue.1_Nonsense_Mutation_p.R739*|DLG1_uc010ial.2_Nonsense_Mutation_p.R751*	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	751	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TCATAATCTCGTTTTGGTCTA	0.313000													18	35					0	0	1	0	0	
DLG1	1739	broad.mit.edu	37	3	196793609	196793609	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:196793609G>A	uc003fxo.3	-	21	2287	c.2097C>T	c.(2095-2097)TAC>TAT	p.Y699Y	DLG1_uc011bub.1_Silent_p.Y595Y|DLG1_uc011buc.1_Silent_p.Y583Y|DLG1_uc011bud.1_Silent_p.Y382Y|DLG1_uc003fxn.3_Silent_p.Y721Y|DLG1_uc011bue.1_Silent_p.Y687Y|DLG1_uc010ial.2_Silent_p.Y699Y	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	699					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		AAGATAAGACGTATTCTTCTT	0.303000													30	60					0	0	1	0	0	
ABCA11P	79963	broad.mit.edu	37	4	420302	420302	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:420302A>C	uc003gae.2	-	5	1139	c.604T>G	c.(604-606)TGT>GGT	p.C202G	ABCA11P_uc003gac.2_Missense_Mutation_p.C151G|ABCA11P_uc003gad.2_RNA|ABCA11P_uc011buv.1_3'UTR|ABCA11P_uc010ibd.1_Missense_Mutation_p.C202G					RecName: Full=Putative ATP-binding cassette sub-family A member 11;												0						TTTGGGACACAGTGAGTTCTC	0.478000													14	27					0	0	1	0	0	
PDE6B	5158	broad.mit.edu	37	4	661762	661762	+	Missense_Mutation	SNP	A	G	G	rs138682290	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:661762A>G	uc003gap.2	+	21	2523	c.2470A>G	c.(2470-2472)AAG>GAG	p.K824E	PDE6B_uc003gao.3_Missense_Mutation_p.K824E|PDE6B_uc011buy.1_Missense_Mutation_p.K545E|PDE6B_uc011buz.1_Missense_Mutation_p.K256E	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	824					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						TCTGGAGGAGAAGGAGGAGGA	0.562000													44	67					0	0	1	0	0	
LOC348926	348926	broad.mit.edu	37	4	3949803	3949803	+	RNA	SNP	C	T	T	rs76496960		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:3949803C>T	uc011bvu.1	-	5		c.532G>A			LOC348926_uc003ghn.2_RNA	NR_024253				Homo sapiens hypothetical protein LOC348926, mRNA (cDNA clone IMAGE:4546485), partial cds.												0						CCCTGCCCTGCGCCCCGAGGT	0.657000													19	30					0	0	1	0	0	
OTOP1	133060	broad.mit.edu	37	4	4199699	4199699	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:4199699G>A	uc003ghp.1	-	5	892	c.862C>T	c.(862-864)CTG>TTG	p.L288L		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	288	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		TTCTTCCACAGGACGTAGAGC	0.562000													27	45					0	0	1	0	0	
OTOP1	133060	broad.mit.edu	37	4	4228387	4228387	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:4228387C>T	uc003ghp.1	-	1	235	c.205G>A	c.(205-207)GTG>ATG	p.V69M		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	69	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCCACGAACACGATCAGCCCA	0.602000													3	5					0	0	1	0	0	
EVC2	132884	broad.mit.edu	37	4	5620262	5620262	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:5620262C>T	uc003gij.2	-	15	2703	c.2649G>A	c.(2647-2649)GCG>GCA	p.A883A	EVC2_uc011bwb.1_Silent_p.A323A|EVC2_uc003gik.2_Silent_p.A803A	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	883						integral to membrane				large_intestine(3)|ovary(2)	5						CTTCTCGCCACGCAGTCTGAA	0.612000													21	30					0	0	1	0	0	
EVC	2121	broad.mit.edu	37	4	5803693	5803693	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:5803693C>T	uc003gil.1	+	16	2505	c.2321C>T	c.(2320-2322)GCG>GTG	p.A774V	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	774					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				CTGATGGAGGCGGCAGTGGAG	0.607000													12	13					0	0	1	0	0	
C4orf50	389197	broad.mit.edu	37	4	5990091	5990091	+	Translation_Start_Site	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:5990091G>T	uc003git.1	-	1	76	c.-14C>A	c.(-16--12)CCCTG>CCATG			NM_207405	NP_997288	Q6ZRC1	CD050_HUMAN	hypothetical protein LOC389197											pancreas(2)|breast(1)	3						CCATTGCTCAGGGAGCTCAGA	0.493000													11	25					7.03913e-09	7.29497e-09	1	1	0	
JAKMIP1	152789	broad.mit.edu	37	4	6107463	6107463	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:6107463G>A	uc003giu.3	-	3	637	c.361C>T	c.(361-363)CGC>TGC	p.R121C	JAKMIP1_uc010idb.1_Missense_Mutation_p.R121C|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Missense_Mutation_p.R121C|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Missense_Mutation_p.R121C|JAKMIP1_uc010ide.2_Missense_Mutation_p.R121C	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	121	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GCGCCGTCGCGCAGCACGTTC	0.731000													10	14					0	0	1	0	0	
JAKMIP1	152789	broad.mit.edu	37	4	6107671	6107671	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:6107671C>T	uc003giu.3	-	3	429	c.153G>A	c.(151-153)CTG>CTA	p.L51L	JAKMIP1_uc010idb.1_Silent_p.L51L|JAKMIP1_uc010idc.1_Intron|JAKMIP1_uc010idd.1_Silent_p.L51L|JAKMIP1_uc011bwc.1_Intron|JAKMIP1_uc003giv.3_Silent_p.L51L|JAKMIP1_uc010ide.2_Silent_p.L51L	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	51	Potential.|Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						TCGCCTCCTGCAGCCGCTCGC	0.527000													13	21					0	0	1	0	0	
SORCS2	57537	broad.mit.edu	37	4	7725544	7725544	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:7725544C>T	uc003gkb.3	+	19	2545	c.2545C>T	c.(2545-2547)CGC>TGC	p.R849C	SORCS2_uc011bwi.1_Missense_Mutation_p.R677C	NM_020777	NP_065828	Q96PQ0	SORC2_HUMAN	VPS10 domain receptor protein SORCS 2 precursor	849	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(1)|central_nervous_system(1)	2						CGGCATCTACCGCGTGTCCGT	0.522000													29	45					0	0	1	0	0	
SH3TC1	54436	broad.mit.edu	37	4	8228895	8228895	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:8228895G>A	uc003gkv.3	+	12	1575	c.1474G>A	c.(1474-1476)GAC>AAC	p.D492N	SH3TC1_uc003gkw.3_Missense_Mutation_p.D416N|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	492							binding			large_intestine(2)|pancreas(1)	3						AGCCGAGGATGACTGGGAGGA	0.662000													7	9					0	0	1	0	0	
ACOX3	8310	broad.mit.edu	37	4	8398744	8398744	+	Missense_Mutation	SNP	C	T	T	rs116281866	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:8398744C>T	uc010idk.2	-	9	1121	c.976G>A	c.(976-978)GCT>ACT	p.A326T	ACOX3_uc003glc.3_Missense_Mutation_p.A326T|ACOX3_uc003gld.3_Missense_Mutation_p.A326T|ACOX3_uc003gle.1_Missense_Mutation_p.A231T	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	326					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						AAGCGAAGAGCGATGGCCACG	0.587000													19	53					0	0	1	0	0	
GPR78	27201	broad.mit.edu	37	4	8588903	8588903	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:8588903G>A	uc003glk.2	+	3	1324	c.905G>A	c.(904-906)CGC>CAC	p.R302H	CPZ_uc003gll.2_Intron	NM_080819	NP_543009	Q96P69	GPR78_HUMAN	G protein-coupled receptor 78	302	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(4)|ovary(2)	6						CGGCCGTTCCGCCAAGTCCTG	0.662000													27	30					0	0	1	0	0	
CPZ	8532	broad.mit.edu	37	4	8608573	8608573	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:8608573G>A	uc003glm.2	+	6	1142	c.1016G>A	c.(1015-1017)CGC>CAC	p.R339H	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.R202H|CPZ_uc003glo.2_Missense_Mutation_p.R328H|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	339					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCGGAGACCCGCGGCGCACGC	0.652000													19	16					0	0	1	0	0	
WDR1	9948	broad.mit.edu	37	4	10080545	10080545	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:10080545G>A	uc003gmf.2	-	12	1648	c.1365C>T	c.(1363-1365)CCC>CCT	p.P455P	WDR1_uc003gmg.2_Silent_p.P315P|WDR1_uc010idm.2_RNA|hsa-mir-3138|MI0014161_5'Flank	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	455	WD 8.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		TGTCCCCGCCGGGGTGCACTG	0.597000													19	27					0	0	1	0	0	
HS3ST1	9957	broad.mit.edu	37	4	11400913	11400913	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:11400913C>T	uc003gmq.2	-	2	1040	c.717G>A	c.(715-717)CCG>CCA	p.P239P		NM_005114	NP_005105	O14792	HS3S1_HUMAN	heparan sulfate D-glucosaminyl	239						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			skin(1)	1						CATTGATCTGCGGCGACAGCT	0.567000													24	26					0	0	1	0	0	
CPEB2	132864	broad.mit.edu	37	4	15009113	15009113	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:15009113A>G	uc003gni.1	+	2	623	c.536A>G	c.(535-537)AAA>AGA	p.K179R	CPEB2_uc003gnj.1_Missense_Mutation_p.K179R|CPEB2_uc003gnk.1_Missense_Mutation_p.K179R|CPEB2_uc003gnl.1_Missense_Mutation_p.K179R|CPEB2_uc003gnm.1_Missense_Mutation_p.K179R|CPEB2_uc003gnn.1_Missense_Mutation_p.K179R	NM_182485	NP_872291	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding	179					regulation of translation	cytoplasm	nucleotide binding|RNA binding			skin(1)	1						GCACCACCGAAATTTACTCGC	0.398000													31	55					0	0	1	0	0	
CCKAR	886	broad.mit.edu	37	4	26483560	26483560	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:26483560G>T	uc003gse.1	-	5	1140	c.987C>A	c.(985-987)ATC>ATA	p.I329I		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	329	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	TGGCGCTGAAGATGGGCATCC	0.607000													33	57					3.11337e-16	3.31179e-16	1	1	0	
TLR1	7096	broad.mit.edu	37	4	38800236	38800236	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:38800236T>C	uc003gtl.2	-	4	491	c.217A>G	c.(217-219)ATT>GTT	p.I73V		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	73	Extracellular (Potential).|LRR 2.				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						ATTATCAAAATCCTCAGTTTT	0.328000													56	103					0	0	1	0	0	
N4BP2	55728	broad.mit.edu	37	4	40127935	40127935	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:40127935G>A	uc003guy.3	+	12	4850	c.4512G>A	c.(4510-4512)CAG>CAA	p.Q1504Q	N4BP2_uc010ifq.2_Silent_p.Q1424Q|N4BP2_uc010ifr.2_Silent_p.Q1424Q	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	1504						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						TTGCCTTACAGGAAAAACATA	0.279000													10	23					0	0	1	0	0	
RBM47	54502	broad.mit.edu	37	4	40440469	40440469	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:40440469C>T	uc003gvc.2	-	4	1152	c.442G>A	c.(442-444)GTG>ATG	p.V148M	RBM47_uc003gvd.2_Missense_Mutation_p.V148M|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.V110M|RBM47_uc003gvg.1_Missense_Mutation_p.V148M	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	148	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CAGTTGTCCACGCTGCAGCAC	0.627000													25	28					0	0	1	0	0	
BEND4	389206	broad.mit.edu	37	4	42145857	42145857	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:42145857G>C	uc003gwn.2	-	3	1222	c.642C>G	c.(640-642)CAC>CAG	p.H214Q	BEND4_uc003gwm.2_Missense_Mutation_p.H214Q|BEND4_uc011byy.1_Missense_Mutation_p.H214Q	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	214											0						CAATGTGACAGTGCTCCTGTC	0.443000													15	19					0	0	1	0	0	
SPATA18	132671	broad.mit.edu	37	4	52943043	52943043	+	Missense_Mutation	SNP	C	A	A	rs150116592		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:52943043C>A	uc003gzl.2	+	7	1135	c.857C>A	c.(856-858)CCG>CAG	p.P286Q	SPATA18_uc010igl.1_RNA|SPATA18_uc011bzq.1_Missense_Mutation_p.P254Q|SPATA18_uc003gzk.1_Missense_Mutation_p.P286Q	NM_145263	NP_660306	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18 homolog	286	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			ovary(2)|skin(2)	4			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GTCAGGAGACCGTCCCCAAAC	0.672000													23	35					7.87624e-14	8.31787e-14	1	1	0	
PDGFRA	5156	broad.mit.edu	37	4	55129867	55129867	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:55129867C>T	uc003han.3	+	4	732	c.401C>T	c.(400-402)ACG>ATG	p.T134M	PDGFRA_uc003haa.2_Intron|PDGFRA_uc003hal.2_Missense_Mutation_p.T134M|PDGFRA_uc010igq.1_Missense_Mutation_p.T28M|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	134	Extracellular (Potential).|Ig-like C2-type 2.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTAGGAATGACGGATTATTTA	0.408000			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			30	89					0	0	1	0	0	
CEP135	9662	broad.mit.edu	37	4	56841070	56841070	+	Nonsense_Mutation	SNP	C	T	T	rs138291324		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:56841070C>T	uc003hbi.2	+	11	1642	c.1408C>T	c.(1408-1410)CGA>TGA	p.R470*	CEP135_uc003hbj.2_Nonsense_Mutation_p.R176*	NM_025009	NP_079285	Q66GS9	CP135_HUMAN	centrosome protein 4	470	Potential.				centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	Glioma(25;0.08)|all_neural(26;0.101)					TATAATACAGCGAAGATCTTG	0.358000													23	59					0	0	1	0	0	
KIAA1211	57482	broad.mit.edu	37	4	57181497	57181497	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:57181497T>C	uc003hbk.2	+	8	2220	c.1829T>C	c.(1828-1830)CTG>CCG	p.L610P	KIAA1211_uc010iha.2_Missense_Mutation_p.L603P|KIAA1211_uc011bzz.1_Missense_Mutation_p.L520P|KIAA1211_uc003hbm.1_Missense_Mutation_p.L496P	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	610										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCAGTCAACCTGAGCCAGATC	0.677000													13	11					0	0	1	0	0	
TMPRSS11F	389208	broad.mit.edu	37	4	68930611	68930611	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:68930611T>C	uc003hdt.1	-	8	856	c.807A>G	c.(805-807)CCA>CCG	p.P269P	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron|SYT14L_uc010ihn.2_5'Flank	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	269	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TCACTGCGGGTGGTGTTATAG	0.348000													15	26					0	0	1	0	0	
YTHDC1	91746	broad.mit.edu	37	4	69182036	69182036	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:69182036C>T	uc003hdx.2	-	16	2308	c.1955G>A	c.(1954-1956)CGA>CAA	p.R652Q	YTHDC1_uc003hdy.2_Missense_Mutation_p.R634Q	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	652	Arg-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						ACTTACTACTCGTTTATCTCT	0.458000													82	111					0	0	1	0	0	
UGT2B10	7365	broad.mit.edu	37	4	69870669	69870669	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:69870669C>A	uc011cao.1	-	9	1517	c.1381G>T	c.(1381-1383)GCT>TCT	p.A461S	UGT2B10_uc011can.1_Missense_Mutation_p.A377S			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	498	Helical; (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GCCACACAGGCCAGCAGGAAC	0.448000													15	143					1.49906e-05	1.52809e-05	1	1	0	
UTP3	57050	broad.mit.edu	37	4	71555158	71555158	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:71555158T>A	uc003hfo.2	+	1	963	c.764T>A	c.(763-765)ATC>AAC	p.I255N		NM_020368	NP_065101	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit processome component	255					brain development|chromatin modification|gene silencing	nucleolus					0			Lung(101;0.235)			GAACAAGGGATCATTCCACCC	0.433000													29	64					0	0	1	0	0	
RUFY3	22902	broad.mit.edu	37	4	71660563	71660563	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:71660563C>T	uc003hfr.2	+	14	2104	c.1509C>T	c.(1507-1509)AAC>AAT	p.N503N	RUFY3_uc011cay.1_Silent_p.N439N	NM_001037442	NP_001032519	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					negative regulation of axonogenesis	filopodium|growth cone					0		all_hematologic(202;0.248)	Lung(101;0.235)			GATTACAAAACGACAGGAGCA	0.363000													36	63					0	0	1	0	0	
CCDC158	339965	broad.mit.edu	37	4	77300523	77300523	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:77300523G>A	uc003hkb.3	-	8	1102	c.949C>T	c.(949-951)CGT>TGT	p.R317C	CCDC158_uc003hkd.2_Missense_Mutation_p.R317C	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	317	Potential.									skin(3)|ovary(2)|pancreas(1)	6						CTGAGCTGACGCATATACATA	0.398000													24	42					0	0	1	0	0	
SHROOM3	57619	broad.mit.edu	37	4	77660524	77660524	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:77660524C>T	uc011cbx.1	+	5	2151	c.1198C>T	c.(1198-1200)CGG>TGG	p.R400W	SHROOM3_uc011cbz.1_Missense_Mutation_p.R224W|SHROOM3_uc003hkf.1_Missense_Mutation_p.R275W|SHROOM3_uc003hkg.2_Missense_Mutation_p.R178W	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	400					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			GCACCGTGAGCGGCCCAGCTC	0.587000													25	42					0	0	1	0	0	
FRAS1	80144	broad.mit.edu	37	4	79300892	79300892	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:79300892C>T	uc003hlb.2	+	27	3745	c.3305C>T	c.(3304-3306)ACC>ATC	p.T1102I	FRAS1_uc003hkw.2_Missense_Mutation_p.T1102I	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1101	CSPG 1.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						AAAATACACACCCCTAGTCTT	0.418000													23	29					0	0	1	0	0	
BMP2K	55589	broad.mit.edu	37	4	79786730	79786730	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:79786730C>T	uc003hlk.2	+	10	1253	c.1087C>T	c.(1087-1089)CCA>TCA	p.P363S	BMP2K_uc010ijl.1_RNA|BMP2K_uc003hlj.2_Missense_Mutation_p.P363S	NM_198892	NP_942595	Q9NSY1	BMP2K_HUMAN	BMP-2 inducible kinase isoform a	363						nucleus	ATP binding|protein serine/threonine kinase activity			lung(1)	1						TACCATTGGACCAACAGAAAC	0.373000													22	34					0	0	1	0	0	
PLAC8	51316	broad.mit.edu	37	4	84026090	84026090	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:84026090C>T	uc003hoe.2	-	3	363	c.202G>A	c.(202-204)GTC>ATC	p.V68I	PLAC8_uc011cco.1_Missense_Mutation_p.V68I|PLAC8_uc010ijy.2_RNA|PLAC8_uc010ijz.2_Intron|PLAC8_uc003hod.2_Missense_Mutation_p.V68I	NM_001130716	NP_001124188	Q9NZF1	PLAC8_HUMAN	placenta-specific 8	68										ovary(1)	1		Hepatocellular(203;0.114)				CTCATTGCGACGCTTGTTCCA	0.448000													26	50					0	0	1	0	0	
SPP1	6696	broad.mit.edu	37	4	88898240	88898240	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:88898240G>T	uc003hra.2	+	3	249	c.84G>T	c.(82-84)GAG>GAT	p.E28D	SPP1_uc003hrb.2_Missense_Mutation_p.E28D|SPP1_uc003hrc.2_Missense_Mutation_p.E28D|SPP1_uc011cde.1_Translation_Start_Site|SPP1_uc003hrd.2_Missense_Mutation_p.E28D	NM_001040058	NP_001035147	P10451	OSTP_HUMAN	secreted phosphoprotein 1 isoform a	28					biomineral tissue development|cell adhesion|decidualization|embryo implantation|ossification|response to vitamin D	extracellular space	cytokine activity			ovary(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-05)		GAAGTTCTGAGGAAAAGCAGG	0.353000													17	28					1.64113e-05	1.67208e-05	1	1	0	
ATOH1	474	broad.mit.edu	37	4	94750179	94750179	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:94750179G>A	uc003hta.1	+	1	102	c.102G>A	c.(100-102)CCG>CCA	p.P34P		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	34	Poly-Pro.				transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CGCCGCCGCCGCCGCAGCCAC	0.672000													19	27					0	0	1	0	0	
ATOH1	474	broad.mit.edu	37	4	94750450	94750450	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:94750450C>T	uc003hta.1	+	1	373	c.373C>T	c.(373-375)CGG>TGG	p.R125W		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	125					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		GGTGAAAGTGCGGGAACAGCT	0.692000													15	27					0	0	1	0	0	
SLC39A8	64116	broad.mit.edu	37	4	103228644	103228644	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:103228644C>T	uc003hwb.1	-	3	1030	c.501G>A	c.(499-501)GGG>GGA	p.G167G	SLC39A8_uc011ceo.1_Silent_p.G167G|SLC39A8_uc003hwa.1_Silent_p.G100G|SLC39A8_uc003hwc.2_Silent_p.G167G	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	167	Helical; (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		CAATAGCCAGCCCCACAAAAA	0.363000													53	102					0	0	1	0	0	
TACR3	6870	broad.mit.edu	37	4	104512673	104512673	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:104512673A>T	uc003hxe.1	-	4	1199	c.1056T>A	c.(1054-1056)AAT>AAA	p.N352K		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	352	Helical; Name=7; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AGATGATGGGATTGTACATGG	0.408000													40	70					0	0	1	0	0	
NPNT	255743	broad.mit.edu	37	4	106861729	106861729	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:106861729C>T	uc003hya.2	+	7	904	c.699C>T	c.(697-699)AAC>AAT	p.N233N	NPNT_uc011cfc.1_Silent_p.N250N|NPNT_uc011cfd.1_Silent_p.N263N|NPNT_uc011cfe.1_Silent_p.N263N|NPNT_uc010ilt.1_Silent_p.N233N|NPNT_uc011cff.1_Silent_p.N233N|NPNT_uc010ilu.1_Silent_p.N129N	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	233	EGF-like 5; calcium-binding (Potential).				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		GATGTTATAACATACGTGGGT	0.423000													39	62					0	0	1	0	0	
ALPK1	80216	broad.mit.edu	37	4	113352968	113352968	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:113352968C>T	uc003iap.3	+	11	2544	c.2265C>T	c.(2263-2265)TGC>TGT	p.C755C	ALPK1_uc003ian.3_Silent_p.C755C|ALPK1_uc011cfx.1_Silent_p.C677C|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Silent_p.C583C	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	755							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		AAACCAACTGCGATGTCAAAG	0.468000													24	44					0	0	1	0	0	
NDST3	9348	broad.mit.edu	37	4	118975891	118975891	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:118975891T>G	uc003ibx.2	+	2	1229	c.826T>G	c.(826-828)TTG>GTG	p.L276V	NDST3_uc011cgf.1_Missense_Mutation_p.L276V|NDST3_uc003ibw.2_Missense_Mutation_p.L276V	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	276	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TGGCAACAACTTGAACTTTTG	0.418000													57	118					0	0	1	0	0	
TRPC3	7222	broad.mit.edu	37	4	122853799	122853799	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:122853799C>T	uc003ieg.2	-	2	688	c.614G>A	c.(613-615)CGT>CAT	p.R205H	TRPC3_uc010inr.2_Missense_Mutation_p.R132H|TRPC3_uc003ief.2_Missense_Mutation_p.R132H|TRPC3_uc011cgl.1_5'UTR	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	120	Cytoplasmic (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						CAGAGTGAGACGCTTGCTGGC	0.647000													18	24					0	0	1	0	0	
ADAD1	132612	broad.mit.edu	37	4	123329146	123329146	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:123329146G>A	uc003ieo.2	+	8	1040	c.808G>A	c.(808-810)GAC>AAC	p.D270N	ADAD1_uc003iep.2_Missense_Mutation_p.D270N|ADAD1_uc003ieq.2_Missense_Mutation_p.D252N	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	270	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						AGTATTGCATGACACTCATGC	0.388000													33	38					0	0	1	0	0	
TBC1D9	23158	broad.mit.edu	37	4	141578953	141578953	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:141578953G>T	uc010ioj.2	-	12	2207	c.1935C>A	c.(1933-1935)GAC>GAA	p.D645E		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	645	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				AGACACCTTGGTCCACCAGTG	0.507000													65	100					9.61042e-55	1.04393e-54	1	1	0	
C4orf51	646603	broad.mit.edu	37	4	146601541	146601541	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:146601541C>T	uc003ikk.2	+	1	186	c.186C>T	c.(184-186)TGC>TGT	p.C62C		NM_001080531	NP_001074000	C9J302	CD051_HUMAN	chromosome 4 open reading frame 51	62											0						AGTCCATGTGCAGCCAATTTT	0.423000													20	26					0	0	1	0	0	
FBXW7	55294	broad.mit.edu	37	4	153247289	153247289	+	Missense_Mutation	SNP	G	A	A	rs149680468		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:153247289G>A	uc003ims.2	-	10	1662	c.1513C>T	c.(1513-1515)CGC>TGC	p.R505C	FBXW7_uc011cii.1_Missense_Mutation_p.R505C|FBXW7_uc003imt.2_Missense_Mutation_p.R505C|FBXW7_uc011cih.1_Missense_Mutation_p.R329C|FBXW7_uc003imq.2_Missense_Mutation_p.R425C|FBXW7_uc003imr.2_Missense_Mutation_p.R387C	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	505	WD 4.		R -> L (in an ovarian cancer cell line).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding	p.R505C(36)|p.R505L(6)|p.R505G(4)|p.R425C(2)|p.R425G(2)|p.R266G(2)|p.R505H(2)|p.R505S(1)|p.R505P(1)|p.R266C(1)		haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				TGAACACAGCGGACTGCTGCA	0.468000			Mis|N|D|F		colorectal|endometrial|T-ALL								52	66					0	0	1	0	0	
TDO2	6999	broad.mit.edu	37	4	156825180	156825180	+	Nonsense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:156825180A>T	uc003ipf.1	+	2	110	c.46A>T	c.(46-48)AAA>TAA	p.K16*		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	16					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	ATATACTTTTAAAAAACTCCC	0.353000													27	46					0	0	1	0	0	
FSTL5	56884	broad.mit.edu	37	4	162697165	162697165	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:162697165A>C	uc003iqh.2	-	5	907	c.471T>G	c.(469-471)AAT>AAG	p.N157K	FSTL5_uc003iqi.2_Missense_Mutation_p.N156K|FSTL5_uc010iqv.2_Missense_Mutation_p.N156K	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	157						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TATATTTTTGATTTTGTAAAT	0.294000													15	34					0	0	1	0	0	
TLL1	7092	broad.mit.edu	37	4	166910564	166910564	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:166910564T>C	uc003irh.1	+	2	848	c.201T>C	c.(199-201)GAT>GAC	p.D67D	TLL1_uc011cjn.1_Silent_p.D67D|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	67					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CCTTAGATGATGAAGACTTAA	0.333000													37	58					0	0	1	0	0	
ANXA10	11199	broad.mit.edu	37	4	169083678	169083678	+	Splice_Site	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:169083678G>A	uc003irm.2	+	4	341	c.196_splice	c.e4-1	p.D66_splice	ANXA10_uc003irn.2_5'Flank	NM_007193	NP_009124	Q9UJ72	ANX10_HUMAN	annexin A10								calcium ion binding|calcium-dependent phospholipid binding				0		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0325)		TTCCTCCACAGGACCTGATTG	0.388000													18	29					0	0	1	0	0	
NEK1	4750	broad.mit.edu	37	4	170322819	170322819	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:170322819G>A	uc003isb.1	-	31	3975	c.3483C>T	c.(3481-3483)AAC>AAT	p.N1161N	NEK1_uc003isc.1_Silent_p.N1117N|NEK1_uc003isd.1_Silent_p.N1189N|NEK1_uc003ise.1_Silent_p.N1145N|NEK1_uc003isf.1_Silent_p.N1092N	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1161					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		GCCATTCTTCGTTCAGGGCAC	0.413000													103	129					0	0	1	0	0	
GALNTL6	442117	broad.mit.edu	37	4	173873245	173873245	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:173873245C>T	uc003isv.2	+	10	1943	c.1207C>T	c.(1207-1209)CGG>TGG	p.R403W		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	403	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						CATTTACCAGCGGCGGCCGGA	0.512000													31	49					0	0	1	0	0	
GALNTL6	442117	broad.mit.edu	37	4	173930422	173930422	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:173930422G>A	uc003isv.2	+	11	2201	c.1465G>A	c.(1465-1467)GAA>AAA	p.E489K		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	489	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						GGATGGTTCTGAAAGAACATG	0.552000													21	44					0	0	1	0	0	
ADAM29	11086	broad.mit.edu	37	4	175898755	175898755	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:175898755T>C	uc003iuc.2	+	5	2749	c.2079T>C	c.(2077-2079)TGT>TGC	p.C693C	ADAM29_uc003iud.2_Silent_p.C693C|ADAM29_uc010irr.2_Silent_p.C693C|ADAM29_uc011cki.1_Silent_p.C693C	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	693	Helical; (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TATTATGTTGTCTTTATCGAC	0.343000													14	17					0	0	1	0	0	
ENPP6	133121	broad.mit.edu	37	4	185038136	185038136	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:185038136A>G	uc003iwc.2	-	5	870	c.728T>C	c.(727-729)ATG>ACG	p.M243T		NM_153343	NP_699174	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	243	Extracellular (Potential).				lipid catabolic process	extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)	1		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		AATGTCGGTCATTCCGTGATC	0.532000													20	38					0	0	1	0	0	
TLR3	7098	broad.mit.edu	37	4	187004768	187004768	+	Missense_Mutation	SNP	G	A	A	rs150315296		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:187004768G>A	uc003iyq.2	+	4	2029	c.1928G>A	c.(1927-1929)CGC>CAC	p.R643H	TLR3_uc011ckz.1_Missense_Mutation_p.R366H|TLR3_uc003iyr.2_Missense_Mutation_p.R366H	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	643	Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TTAGATATGCGCTTTAATCCC	0.433000													60	82					0	0	1	0	0	
FAT1	2195	broad.mit.edu	37	4	187541438	187541438	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:187541438C>T	uc003izf.2	-	10	6490	c.6302G>A	c.(6301-6303)CGC>CAC	p.R2101H		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2101	Extracellular (Potential).|Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AGTGACATAGCGAATGACATG	0.468000										HNSCC(5;0.00058)			63	135					0	0	1	0	0	
SDHA	6389	broad.mit.edu	37	5	230997	230997	+	Silent	SNP	C	T	T	rs140243793		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:230997C>T	uc003jao.3	+	7	892	c.777C>T	c.(775-777)TAC>TAT	p.Y259Y	SDHA_uc003jan.2_Silent_p.Y259Y|SDHA_uc011clv.1_Silent_p.Y259Y|SDHA_uc011clw.1_Silent_p.Y211Y|SDHA_uc003jap.3_Silent_p.Y259Y|SDHA_uc003jaq.3_Silent_p.Y34Y|SDHA_uc003jar.3_Translation_Start_Site	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	259					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	CCAGAGGCTACGGGCGCACCT	0.602000									Familial_Paragangliomas				18	54					0	0	1	0	0	
SDHA	6389	broad.mit.edu	37	5	233669	233669	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:233669A>G	uc003jao.3	+	8	1088	c.973A>G	c.(973-975)AGG>GGG	p.R325G	SDHA_uc003jan.2_Missense_Mutation_p.R325G|SDHA_uc011clv.1_Missense_Mutation_p.R325G|SDHA_uc011clw.1_Missense_Mutation_p.R277G|SDHA_uc003jap.3_Missense_Mutation_p.R325G|SDHA_uc003jaq.3_Missense_Mutation_p.R100G|SDHA_uc003jar.3_5'UTR	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	325					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TCAAGGCGAAAGGTTTATGGA	0.507000									Familial_Paragangliomas				66	112					0	0	1	0	0	
CLPTM1L	81037	broad.mit.edu	37	5	1335244	1335244	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:1335244C>T	uc003jch.2	-	6	770	c.724G>A	c.(724-726)GAC>AAC	p.D242N	CLPTM1L_uc003jcg.2_Missense_Mutation_p.D109N	NM_030782	NP_110409	Q96KA5	CLP1L_HUMAN	CLPTM1-like	242	Extracellular (Potential).				apoptosis	integral to membrane				breast(1)|central_nervous_system(1)	2	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		GAGACCTTGTCGTAGGACACG	0.637000													47	63					0	0	1	0	0	
FASTKD3	79072	broad.mit.edu	37	5	7867738	7867738	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:7867738T>C	uc003jeb.2	-	2	596	c.459A>G	c.(457-459)ATA>ATG	p.I153M	FASTKD3_uc011cmp.1_Intron|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	153					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						TATTCTCCAGTATTTCTTTTG	0.438000													29	44					0	0	1	0	0	
TRIO	7204	broad.mit.edu	37	5	14291209	14291209	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:14291209C>T	uc003jff.2	+	5	931	c.925C>T	c.(925-927)CCC>TCC	p.P309S	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.P260S|TRIO_uc003jfh.1_5'Flank	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	309					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GAACCTCTTGCCCAAGGTGTC	0.557000													39	51					0	0	1	0	0	
TRIO	7204	broad.mit.edu	37	5	14364895	14364895	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:14364895G>A	uc003jff.2	+	15	2730	c.2724G>A	c.(2722-2724)CAG>CAA	p.Q908Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.Q859Q|TRIO_uc003jfh.1_Silent_p.Q557Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	908	Spectrin 3.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGTGCGTGCAGCTGCGCCACC	0.547000											OREG0016458	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	27					0	0	1	0	0	
FAM134B	54463	broad.mit.edu	37	5	16475174	16475174	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:16475174C>T	uc003jfs.2	-	9	1208	c.1170G>A	c.(1168-1170)ACG>ACA	p.T390T	FAM134B_uc003jfr.2_Silent_p.T249T	NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	390					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						CTGCTGATTGCGTCTCTTTGC	0.493000													37	44					0	0	1	0	0	
MYO10	4651	broad.mit.edu	37	5	16794807	16794807	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:16794807C>T	uc003jft.3	-	4	883	c.415G>A	c.(415-417)GAG>AAG	p.E139K	MYO10_uc003jfu.2_Missense_Mutation_p.E106K	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	139	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CGGTAGCACTCGTTGGCGATG	0.657000													10	22					0	0	1	0	0	
BASP1	10409	broad.mit.edu	37	5	17275856	17275856	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:17275856G>A	uc003jfx.2	+	2	710	c.531G>A	c.(529-531)TCG>TCA	p.S177S		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	177					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						CCGGCAGCTCGGAGGCTGCCC	0.662000													12	13					0	0	1	0	0	
CDH9	1007	broad.mit.edu	37	5	26885830	26885830	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:26885830T>G	uc003jgs.1	-	11	1944	c.1775A>C	c.(1774-1776)GAT>GCT	p.D592A	CDH9_uc011cnv.1_Missense_Mutation_p.D185A	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	592	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TCCTTGATTATCGCAGGCACA	0.473000													11	17					0	0	1	0	0	
PDZD2	23037	broad.mit.edu	37	5	31983496	31983496	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:31983496G>A	uc003jhl.2	+	3	1100	c.712G>A	c.(712-714)GCT>ACT	p.A238T	PDZD2_uc003jhm.2_Missense_Mutation_p.A238T|PDZD2_uc011cnx.1_Missense_Mutation_p.A64T	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	238					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CAAGGGCAGCGCTGGCTGTGA	0.572000													34	55					0	0	1	0	0	
SKP2	6502	broad.mit.edu	37	5	36182090	36182090	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:36182090G>A	uc003jkc.1	+	10	1414	c.1232G>A	c.(1231-1233)GGC>GAC	p.G411D	SKP2_uc011cou.1_Missense_Mutation_p.G197D|SKP2_uc003jkd.2_Intron	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	411					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGATATGGGGCATCAAATGC	0.448000													17	33					0	0	1	0	0	
RICTOR	253260	broad.mit.edu	37	5	38963142	38963142	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:38963142G>A	uc003jlp.2	-	17	1426	c.1402C>T	c.(1402-1404)CGA>TGA	p.R468*	RICTOR_uc003jlo.2_Nonsense_Mutation_p.R468*|RICTOR_uc010ivf.2_Nonsense_Mutation_p.R183*	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	468					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					GCACTGGCTCGCCTAATGAGA	0.358000													18	35					0	0	1	0	0	
FBXO4	26272	broad.mit.edu	37	5	41941319	41941319	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:41941319T>C	uc003jmq.2	+	7	1156	c.1100T>C	c.(1099-1101)CTG>CCG	p.L367P	FBXO4_uc003jmr.2_3'UTR	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	367					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				GCTGAAACTCTGACTGGTTTT	0.388000													22	40					0	0	1	0	0	
FBXO4	26272	broad.mit.edu	37	5	41941337	41941337	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:41941337G>A	uc003jmq.2	+	7	1174	c.1118G>A	c.(1117-1119)GGC>GAC	p.G373D	FBXO4_uc003jmr.2_3'UTR	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	373					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				TTTTTGAATGGCATTGAGTGG	0.373000													28	42					0	0	1	0	0	
ZNF131	7690	broad.mit.edu	37	5	43174881	43174881	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:43174881C>T	uc011cpw.1	+	7	1554	c.1518C>T	c.(1516-1518)AGC>AGT	p.S506S	ZNF131_uc003jnj.3_Silent_p.S227S|ZNF131_uc003jnk.2_Silent_p.S472S|ZNF131_uc003jnn.3_Silent_p.S227S|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	506						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TCCAGGACAGCCAGGTGCACG	0.493000													4	39					0	0	1	0	0	
ITGA2	3673	broad.mit.edu	37	5	52344542	52344542	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:52344542T>A	uc003joy.2	+	6	715	c.572T>A	c.(571-573)GTA>GAA	p.V191E	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.V115E|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	191	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TGGGATGCAGTAAAGAATTTT	0.388000													51	91					0	0	1	0	0	
SNX18	112574	broad.mit.edu	37	5	53814892	53814892	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:53814892G>A	uc003jpj.3	+	1	1300	c.1110G>A	c.(1108-1110)GCG>GCA	p.A370A	SNX18_uc011cqg.1_Silent_p.A370A|SNX18_uc003jpi.3_Silent_p.A370A	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	370	PX.				cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				CAGTGCTGGCGCAGTGCGACG	0.622000													17	18					0	0	1	0	0	
DHX29	54505	broad.mit.edu	37	5	54603263	54603263	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:54603263T>C	uc003jpx.2	-	1	259	c.139A>G	c.(139-141)ACC>GCC	p.T47A	SKIV2L2_uc003jpy.3_5'Flank|SKIV2L2_uc011cqi.1_5'Flank|DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	47	Ala-rich.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GCGGCAGCGGTGGCCGGCCTG	0.687000													33	65					0	0	1	0	0	
SKIV2L2	23517	broad.mit.edu	37	5	54618225	54618225	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:54618225G>A	uc003jpy.3	+	2	471	c.205G>A	c.(205-207)GAA>AAA	p.E69K	SKIV2L2_uc011cqi.1_Intron	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	69					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGTAGATTTCGAAGGTACAGA	0.313000													53	100					0	0	1	0	0	
CARTPT	9607	broad.mit.edu	37	5	71015160	71015160	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:71015160G>A	uc003kbv.1	+	1	167	c.40G>A	c.(40-42)GCC>ACC	p.A14T		NM_004291	NP_004282	Q16568	CART_HUMAN	cocaine- and amphetamine-regulated transcript	14					activation of MAPKK activity|adult feeding behavior|cellular glucose homeostasis|cellular response to starvation|circadian regulation of gene expression|negative regulation of appetite|negative regulation of bone resorption|negative regulation of osteoclast differentiation|neuropeptide signaling pathway|positive regulation of blood pressure|positive regulation of epinephrine secretion|positive regulation of transmission of nerve impulse|synaptic transmission	extracellular space				ovary(1)	1		Lung NSC(167;0.00153)|Ovarian(174;0.0175)|Prostate(74;0.11)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;8.4e-56)	Amphetamine(DB00182)	CCTCCTGGGCGCCGCCCTGCT	0.652000													26	50					0	0	1	0	0	
HMGCR	3156	broad.mit.edu	37	5	74655087	74655087	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:74655087C>T	uc003kdp.2	+	17	2406	c.2250C>T	c.(2248-2250)AAC>AAT	p.N750N	HMGCR_uc011cst.1_Silent_p.N770N|HMGCR_uc003kdq.2_Silent_p.N697N|HMGCR_uc010izo.2_Silent_p.N73N|HMGCR_uc010izp.2_Intron	NM_000859	NP_000850	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	750	Catalytic.				cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			ovary(1)	1		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	GAGGCTACAACGCCCATGCAG	0.468000													26	9					0	0	1	0	0	
IQGAP2	10788	broad.mit.edu	37	5	75871586	75871586	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:75871586C>T	uc003kek.2	+	5	672	c.450C>T	c.(448-450)CAC>CAT	p.H150H		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	150	CH.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ATTGCATTCACGCACTGAGGT	0.284000													17	40					0	0	1	0	0	
AP3B1	8546	broad.mit.edu	37	5	77334885	77334885	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:77334885G>A	uc003kfj.2	-	23	2916	c.2791C>T	c.(2791-2793)CAT>TAT	p.H931Y		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	931					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TTAAAAACATGCATTTTCATG	0.259000									Hermansky-Pudlak_syndrome				18	19					0	0	1	0	0	
THBS4	7060	broad.mit.edu	37	5	79366474	79366474	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:79366474C>T	uc003kgh.2	+	13	1784	c.1461C>T	c.(1459-1461)TGC>TGT	p.C487C	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	487	TSP type-3 1.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		AGGACAACTGCAAATATGTGC	0.478000													44	78					0	0	1	0	0	
VCAN	1462	broad.mit.edu	37	5	82833213	82833213	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:82833213C>G	uc003kii.3	+	8	4747	c.4391C>G	c.(4390-4392)GCT>GGT	p.A1464G	VCAN_uc003kij.3_Missense_Mutation_p.A477G|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.A128G	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1464	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTGTCTACTGCTGTGCAACCT	0.423000													31	54					0	0	1	0	0	
VCAN	1462	broad.mit.edu	37	5	82834710	82834710	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:82834710C>T	uc003kii.3	+	8	6244	c.5888C>T	c.(5887-5889)GCA>GTA	p.A1963V	VCAN_uc003kij.3_Missense_Mutation_p.A976V|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.A627V	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1963	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GGAGATGCAGCATTTAGGGAC	0.453000													30	38					0	0	1	0	0	
VCAN	1462	broad.mit.edu	37	5	82836247	82836247	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:82836247A>C	uc003kii.3	+	8	7781	c.7425A>C	c.(7423-7425)AAA>AAC	p.K2475N	VCAN_uc003kij.3_Missense_Mutation_p.K1488N|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.K1139N	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2475	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAAGCGCTAAAGCTGTTACTG	0.468000													45	48					0	0	1	0	0	
EDIL3	10085	broad.mit.edu	37	5	83680199	83680199	+	Translation_Start_Site	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:83680199G>A	uc003kio.1	-	1	413	c.-6C>T	c.(-8--4)GACGG>GATGG		EDIL3_uc003kip.1_Translation_Start_Site	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like						cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TCATGATCCCGTCTCCCGGAC	0.672000													22	48					0	0	1	0	0	
GPR98	84059	broad.mit.edu	37	5	90119297	90119297	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:90119297G>A	uc003kju.2	+	76	16348	c.16252G>A	c.(16252-16254)GTG>ATG	p.V5418M	GPR98_uc003kjt.2_Missense_Mutation_p.V3124M|GPR98_uc003kjw.2_Missense_Mutation_p.V1079M	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5418	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AACAGTCGTCGTGCTCCAGAA	0.478000													23	39					0	0	1	0	0	
ANKRD32	84250	broad.mit.edu	37	5	94024237	94024237	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:94024237G>A	uc003kkr.3	+	17	2228	c.2148G>A	c.(2146-2148)GGG>GGA	p.G716G	ANKRD32_uc003kks.2_Silent_p.G80G	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	716										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CAGCCTTGGGGAAAACTGGTG	0.363000													21	50					0	0	1	0	0	
ARSK	153642	broad.mit.edu	37	5	94901772	94901772	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:94901772G>A	uc003kld.2	+	2	355	c.197G>A	c.(196-198)CGT>CAT	p.R66H	ARSK_uc010jbg.2_Translation_Start_Site|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	66						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		ATGAAGACACGTGGGACTTCC	0.393000													24	22					0	0	1	0	0	
RHOBTB3	22836	broad.mit.edu	37	5	95119641	95119641	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:95119641A>G	uc003klm.2	+	10	2134	c.1597A>G	c.(1597-1599)ATA>GTA	p.I533V		NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	533	Interaction with Rab9.			I->K: Abolishes interaction with RAB9A.	retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		GAACCTTGATATAGTTGACCT	0.368000													7	71					0	0	1	0	0	
ELL2	22936	broad.mit.edu	37	5	95234256	95234256	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:95234256G>A	uc003klr.3	-	8	1563	c.1213C>T	c.(1213-1215)CGG>TGG	p.R405W		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	405					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TGAGTCCCCCGGCCTTCTGGA	0.483000													26	57					0	0	1	0	0	
ERAP2	64167	broad.mit.edu	37	5	96244744	96244744	+	Missense_Mutation	SNP	G	A	A	rs150106511		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:96244744G>A	uc003kmq.2	+	14	2802	c.2092G>A	c.(2092-2094)GAA>AAA	p.E698K	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.E698K|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.E647K|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	698	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		CGCACTTCTCGAAGGTCTGAG	0.413000													40	62					0	0	1	0	0	
NUDT12	83594	broad.mit.edu	37	5	102895167	102895167	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:102895167C>T	uc003koi.2	-	3	302	c.209G>A	c.(208-210)TGT>TAT	p.C70Y	NUDT12_uc011cvb.1_Missense_Mutation_p.C52Y|NUDT12_uc010jbq.1_3'UTR	NM_031438	NP_113626	Q9BQG2	NUD12_HUMAN	nudix-type motif 12	70	ANK 2.					nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity				0		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		TGATCTGTCACACCTATAGAT	0.323000													18	36					0	0	1	0	0	
FBXL17	64839	broad.mit.edu	37	5	107559886	107559886	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:107559886T>G	uc011cvc.1	-	5	1957	c.1550A>C	c.(1549-1551)GAG>GCG	p.E517A	FBXL17_uc003kon.3_Missense_Mutation_p.E119A	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	517											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		ATATTGAAGCTCAGGACAGTG	0.388000													28	45					0	0	1	0	0	
KCNN2	3781	broad.mit.edu	37	5	113698877	113698877	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:113698877C>T	uc003kqo.2	+	1	862	c.405C>T	c.(403-405)AGC>AGT	p.S135S		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	135						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		AGCGGCTCAGCGACTACGCGC	0.547000													20	28					0	0	1	0	0	
AQPEP	206338	broad.mit.edu	37	5	115298452	115298452	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:115298452G>A	uc003kro.2	+	1	302	c.138G>A	c.(136-138)TCG>TCA	p.S46S	AQPEP_uc003krp.2_RNA|uc003krn.1_5'UTR	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	46	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						TCCCACCGTCGGAGCTGCCTG	0.701000													15	38					0	0	1	0	0	
SEMA6A	57556	broad.mit.edu	37	5	115783385	115783385	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:115783385C>T	uc010jck.2	-	19	2726	c.2017G>A	c.(2017-2019)GTC>ATC	p.V673I	SEMA6A_uc003krx.3_Missense_Mutation_p.V690I|SEMA6A_uc011cwe.1_Missense_Mutation_p.V52I|SEMA6A_uc003krv.3_Missense_Mutation_p.V100I|SEMA6A_uc003krw.3_Missense_Mutation_p.V150I|SEMA6A_uc010jcj.2_Missense_Mutation_p.V217I	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	673	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGATCACAGACGCAGTAGACG	0.622000													22	18					0	0	1	0	0	
PHAX	51808	broad.mit.edu	37	5	125939525	125939525	+	Silent	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:125939525T>G	uc003kua.1	+	2	382	c.360T>G	c.(358-360)GCT>GCG	p.A120A		NM_032177	NP_115553	Q9H814	PHAX_HUMAN	RNA U, small nuclear RNA export adaptor	120	Necessary for interaction with CBP80 (By similarity).				ncRNA metabolic process|protein transport|snRNA export from nucleus|spliceosomal snRNP assembly	Cajal body|cytosol	RNA binding				0						TATGGGGTGCTGTGCTGCAGG	0.478000													29	29					0	0	1	0	0	
SHROOM1	134549	broad.mit.edu	37	5	132159958	132159958	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:132159958C>T	uc003kxx.2	-	7	2200	c.1395G>A	c.(1393-1395)AGG>AGA	p.R465R	SHROOM1_uc003kxy.1_Silent_p.R465R	NM_133456	NP_597713	Q2M3G4	SHRM1_HUMAN	shroom family member 1	465					actin filament bundle assembly|cell morphogenesis	cytoplasm|microtubule	actin filament binding			pancreas(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGCTTGTGGGCCTGGAAATAC	0.567000													19	22					0	0	1	0	0	
PHF15	23338	broad.mit.edu	37	5	133914490	133914490	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:133914490C>T	uc003kzo.1	+	11	2035	c.1856C>T	c.(1855-1857)ACG>ATG	p.T619M	PHF15_uc011cxt.1_Missense_Mutation_p.T663M|PHF15_uc003kzk.2_Missense_Mutation_p.T679M|PHF15_uc003kzm.2_Missense_Mutation_p.T620M|PHF15_uc003kzn.2_3'UTR	NM_015288	NP_056103	Q9NQC1	JADE2_HUMAN	PHD finger protein 15	619	Pro-rich.				histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGTTCACGGACGACTCCAGAC	0.657000													14	39					0	0	1	0	0	
TGFBI	7045	broad.mit.edu	37	5	135391436	135391436	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:135391436C>T	uc003lbf.3	+	11	1639	c.1478C>T	c.(1477-1479)ACG>ATG	p.T493M	TGFBI_uc003lbg.3_Missense_Mutation_p.T226M|TGFBI_uc003lbh.3_Missense_Mutation_p.T319M|TGFBI_uc011cyb.1_Missense_Mutation_p.T319M|TGFBI_uc010jed.2_Missense_Mutation_p.T226M	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	493	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACCCTGTTCACGATGGACCGG	0.567000													7	30					0	0	1	0	0	
PKD2L2	27039	broad.mit.edu	37	5	137244597	137244597	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:137244597A>G	uc003lby.2	+	8	1346	c.1290A>G	c.(1288-1290)GGA>GGG	p.G430G	PKD2L2_uc003lbw.1_Silent_p.G430G|PKD2L2_uc003lbx.2_Intron|PKD2L2_uc011cyi.1_Silent_p.G38G	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	430	Extracellular (Potential).					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTGTTTTTGGATCACAAGTTG	0.303000													3	36					0	0	1	0	0	
CTNNA1	1495	broad.mit.edu	37	5	138145810	138145810	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:138145810C>T	uc003ldh.2	+	4	480	c.385C>T	c.(385-387)CGA>TGA	p.R129*	CTNNA1_uc011cyx.1_Nonsense_Mutation_p.R26*|CTNNA1_uc011cyy.1_Nonsense_Mutation_p.R6*|CTNNA1_uc003ldi.2_Intron|CTNNA1_uc003ldj.2_Nonsense_Mutation_p.R129*	NM_001903	NP_001894	P35221	CTNA1_HUMAN	catenin, alpha 1	129	Interaction with JUP and CTNNB1.|Involved in homodimerization.			R -> P (in Ref. 3; AAA18949).	adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			breast(6)|ovary(2)|large_intestine(2)|kidney(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TCGGGCAGCTCGAGCTTTGCT	0.473000													36	50					0	0	1	0	0	
PCDHA1	56147	broad.mit.edu	37	5	140166926	140166926	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140166926G>A	uc003lhb.2	+	1	1051	c.1051G>A	c.(1051-1053)GCG>ACG	p.A351T	PCDHA1_uc003lha.2_Missense_Mutation_p.A351T|PCDHA1_uc003lgz.2_Missense_Mutation_p.A351T	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	351	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAGAACTGGCGGTCACTTC	0.483000													36	53					0	0	1	0	0	
PCDHA10	56139	broad.mit.edu	37	5	140237715	140237715	+	Silent	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140237715C>G	uc003lhx.2	+	1	2082	c.2082C>G	c.(2080-2082)GTC>GTG	p.V694V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Silent_p.V694V	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	694	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTGGATGTCAACGTGTACC	0.672000													23	35					0	0	1	0	0	
PCDHA11	56138	broad.mit.edu	37	5	140250745	140250745	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140250745C>T	uc003lia.2	+	1	2915	c.2057C>T	c.(2056-2058)GCG>GTG	p.A686V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.A686V	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	686	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGGGCGCCGCGAGCCCAGAG	0.667000													35	43					0	0	1	0	0	
PCDHA12	56137	broad.mit.edu	37	5	140256290	140256290	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140256290C>T	uc003lic.2	+	1	1360	c.1233C>T	c.(1231-1233)AGC>AGT	p.S411S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.S411S	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	411	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCTGGACAGCGCCCTGGACC	0.607000													80	168					0	0	1	0	0	
PCDHB1	29930	broad.mit.edu	37	5	140431806	140431806	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140431806G>A	uc003lik.1	+	1	828	c.751G>A	c.(751-753)GTA>ATA	p.V251I		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	251	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGAGCCCAGGTATCAGAGAA	0.567000													8	21					0	0	1	0	0	
PCDHB2	56133	broad.mit.edu	37	5	140474383	140474383	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140474383C>T	uc003lil.2	+	1	147	c.9C>T	c.(7-9)GCC>GCT	p.A3A	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	3					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAATGGAGGCCGGAGAGGGGA	0.532000													17	29					0	0	1	0	0	
PCDHB2	56133	broad.mit.edu	37	5	140474556	140474556	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140474556T>G	uc003lil.2	+	1	320	c.182T>G	c.(181-183)CTT>CGT	p.L61R	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	61	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATAGGAGAACTTGCTGTGAGG	0.502000													25	22					0	0	1	0	0	
PCDHB5	26167	broad.mit.edu	37	5	140517067	140517067	+	Missense_Mutation	SNP	C	T	T	rs150651540		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140517067C>T	uc003liq.2	+	1	2268	c.2051C>T	c.(2050-2052)TCG>TTG	p.S684L		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	684	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGGCCGACTCGCTCACTGTC	0.697000													76	121					0	0	1	0	0	
PCDHB6	56130	broad.mit.edu	37	5	140530541	140530541	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140530541A>G	uc003lir.2	+	1	703	c.703A>G	c.(703-705)AAT>GAT	p.N235D	PCDHB6_uc011dah.1_Missense_Mutation_p.N99D	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	235	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTTGGACATCAATGACAACGT	0.572000													24	36					0	0	1	0	0	
PCDHB17	54661	broad.mit.edu	37	5	140537160	140537160	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140537160C>T	uc003lis.2	+	1	1581	c.1581C>T	c.(1579-1581)TTC>TTT	p.F527F		NR_001280				SubName: Full=Protocadherin-psi1;												0						TGCAGGAGTTCGAGTTCCGCG	0.657000													45	76					0	0	1	0	0	
PCDHB17	54661	broad.mit.edu	37	5	140537175	140537175	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140537175C>T	uc003lis.2	+	1	1596	c.1596C>T	c.(1594-1596)GGC>GGT	p.G532G		NR_001280				SubName: Full=Protocadherin-psi1;												0						TCCGCGTGGGCGCCTCAGACC	0.657000													39	63					0	0	1	0	0	
PCDHB7	56129	broad.mit.edu	37	5	140553461	140553461	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140553461C>A	uc003lit.2	+	1	1219	c.1045C>A	c.(1045-1047)CTG>ATG	p.L349M		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	349	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAGCTGCTCCTGTCTTCACT	0.463000													24	27					1.66031e-10	1.73554e-10	1	1	0	
PCDHB7	56129	broad.mit.edu	37	5	140554770	140554770	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140554770G>A	uc003lit.2	+	1	2528	c.2354G>A	c.(2353-2355)CGC>CAC	p.R785H	PCDHB8_uc011dai.1_5'Flank	NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	785	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAGAAAATCGCCCATTTCAG	0.443000													14	131					0	0	1	0	0	
PCDHB8	56128	broad.mit.edu	37	5	140559570	140559570	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140559570C>T	uc011dai.1	+	1	2141	c.1955C>T	c.(1954-1956)CCG>CTG	p.P652L	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	652	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCGAGCCTCCGTGCTCGGCC	0.711000													20	37					0	0	1	0	0	
PCDHB18	54660	broad.mit.edu	37	5	140615913	140615913	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140615913C>T	uc003ljc.1	+	1	1976	c.1628C>T	c.(1627-1629)TCG>TTG	p.S543L		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						GACGGCGACTCGGGCCAGAAC	0.721000													53	85					0	0	1	0	0	
PCDHB15	56121	broad.mit.edu	37	5	140626234	140626234	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140626234C>T	uc003lje.2	+	1	1088	c.1088C>T	c.(1087-1089)ACA>ATA	p.T363I		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	363	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTCCAGAGACAGAAGTGGCC	0.418000													46	61					0	0	1	0	0	
PCDHGA7	56108	broad.mit.edu	37	5	140762727	140762727	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140762727G>A	uc003lka.1	+	1	261	c.261G>A	c.(259-261)GCG>GCA	p.A87A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.A87A	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	87	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCACTGCGGGCAGGATAG	0.572000													39	63					0	0	1	0	0	
PCDHGA7	56108	broad.mit.edu	37	5	140763083	140763083	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140763083G>A	uc003lka.1	+	1	617	c.617G>A	c.(616-618)CGG>CAG	p.R206Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.R206Q	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	206	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGAAGAGCGGGTTCACCAC	0.622000													7	11					0	0	1	0	0	
PCDHGB5	56101	broad.mit.edu	37	5	140779342	140779342	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140779342G>A	uc003lkf.1	+	1	1648	c.1648G>A	c.(1648-1650)GAC>AAC	p.D550N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.D550N	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	550	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGGTGGGCGACCGAAACGA	0.677000													19	26					0	0	1	0	0	
PCDHGA11	56105	broad.mit.edu	37	5	140800995	140800995	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140800995C>T	uc003lkq.1	+	1	459	c.201C>T	c.(199-201)ATC>ATT	p.I67I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Silent_p.I67I|PCDHGA11_uc003lkp.1_Silent_p.I67I	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	67	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGTCCGCATCGTCTCCAGAG	0.612000													29	58					0	0	1	0	0	
PCDHGB8P	56120	broad.mit.edu	37	5	140807364	140807364	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140807364G>A	uc011daz.1	+	1	1512	c.1153G>A	c.(1153-1155)GTG>ATG	p.V385M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_5'Flank|PCDHGA12_uc003lkt.1_5'Flank	NR_001297				Homo sapiens PCDH-psi3 pseudogene, mRNA sequence.												0						CTACGTGTCCGTGAGCGCACA	0.647000													14	9					0	0	1	0	0	
PCDHGA12	26025	broad.mit.edu	37	5	140811757	140811757	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:140811757C>T	uc003lkt.1	+	1	1600	c.1431C>T	c.(1429-1431)CAC>CAT	p.H477H	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Silent_p.H477H	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	477	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACCGCCCACGACCCCGACT	0.562000													19	28					0	0	1	0	0	
HDAC3	8841	broad.mit.edu	37	5	141008157	141008157	+	Silent	SNP	G	A	A	rs141006049		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:141008157G>A	uc003llf.2	-	8	726	c.660C>T	c.(658-660)AAC>AAT	p.N220N	HDAC3_uc003lle.1_Silent_p.N163N	NM_003883	NP_003874	O15379	HDAC3_HUMAN	histone deacetylase 3	220	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	GCAGGGGCACGTTCAGACAGT	0.542000													33	50					0	0	1	0	0	
ARHGAP26	23092	broad.mit.edu	37	5	142500657	142500657	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:142500657T>C	uc011dbj.1	+	18	1678	c.1643T>C	c.(1642-1644)ATG>ACG	p.M548T	ARHGAP26_uc003lmt.2_Missense_Mutation_p.M548T|ARHGAP26_uc003lmw.2_Missense_Mutation_p.M548T	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	548	Rho-GAP.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAGCCATCATGGACATCAAA	0.443000													34	63					0	0	1	0	0	
SH3RF2	153769	broad.mit.edu	37	5	145442093	145442093	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:145442093G>A	uc003lnt.2	+	10	2257	c.2019G>A	c.(2017-2019)GCG>GCA	p.A673A	SH3RF2_uc011dbl.1_Silent_p.A673A|SH3RF2_uc003lnu.2_Silent_p.A164A|SH3RF2_uc011dbn.1_Silent_p.A164A|SH3RF2_uc011dbo.1_Silent_p.A130A	NM_152550	NP_689763	Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	673							ligase activity|protein phosphatase 1 binding|zinc ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCTCAAGGCGTCCCAGCCTG	0.577000													26	51					0	0	1	0	0	
TCERG1	10915	broad.mit.edu	37	5	145849218	145849218	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:145849218A>T	uc003lob.2	+	7	1350	c.1310A>T	c.(1309-1311)GAA>GTA	p.E437V	TCERG1_uc003loc.2_Missense_Mutation_p.E416V|TCERG1_uc011dbt.1_Missense_Mutation_p.E416V	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	437	WW 2.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAATGGACTGAATATAAAACA	0.413000													73	121					0	0	1	0	0	
CCNJL	79616	broad.mit.edu	37	5	159707575	159707575	+	Silent	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:159707575G>T	uc003lyb.1	-	3	489	c.237C>A	c.(235-237)TCC>TCA	p.S79S	CCNJL_uc011dee.1_Silent_p.S79S|CCNJL_uc003lyc.1_RNA|CCNJL_uc011def.1_Silent_p.S79S	NM_024565	NP_078841	Q8IV13	CCNJL_HUMAN	cyclin J-like	79	Cyclin N-terminal.					nucleus					0	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAGCTGCTTGGAGGTGGTGA	0.627000													45	67					2.12129e-23	2.27772e-23	1	1	0	
ATP10B	23120	broad.mit.edu	37	5	160042941	160042941	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:160042941C>T	uc003lym.1	-	17	3404	c.2557G>A	c.(2557-2559)GCC>ACC	p.A853T	ATP10B_uc010jit.1_Missense_Mutation_p.A170T|ATP10B_uc003lyn.2_Missense_Mutation_p.A411T	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	853	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CGGAAACTGGCCCATCTCCGG	0.507000													14	27					0	0	1	0	0	
GABRA1	2554	broad.mit.edu	37	5	161292758	161292758	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:161292758C>T	uc010jiw.2	+	5	687	c.219C>T	c.(217-219)TTC>TTT	p.F73F	GABRA1_uc010jix.2_Silent_p.F73F|GABRA1_uc010jiy.2_Silent_p.F73F|GABRA1_uc003lyx.3_Silent_p.F73F|GABRA1_uc010jiz.2_Silent_p.F73F|GABRA1_uc010jja.2_Silent_p.F73F|GABRA1_uc010jjb.2_Silent_p.F73F	NM_000806	NP_000797	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha	73	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|pancreas(1)	3	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	CTGATATCTTCGTCACCAGTT	0.398000													65	87					0	0	1	0	0	
DUSP1	1843	broad.mit.edu	37	5	172195819	172195819	+	Silent	SNP	C	T	T	rs138845473		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:172195819C>T	uc003mbv.1	-	4	1298	c.1050G>A	c.(1048-1050)ACG>ACA	p.T350T	DUSP1_uc011dez.1_Silent_p.T208T|DUSP1_uc003mbu.1_Silent_p.T238T	NM_004417	NP_004408	P28562	DUS1_HUMAN	dual specificity phosphatase 1	350	Tyrosine-protein phosphatase.				cell cycle|endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|protein binding			breast(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00431)|all_lung(126;0.00729)	all_hematologic(541;4.11e-18)|Breast(839;0.00637)|Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.15)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)	GBM - Glioblastoma multiforme(465;0.0103)		GCGCACTGTTCGTGGAGTGGA	0.622000													6	84					0	0	1	0	0	
BNIP1	662	broad.mit.edu	37	5	172585829	172585829	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:172585829G>A	uc003mcj.3	+	4	456	c.352G>A	c.(352-354)GGA>AGA	p.G118R	BNIP1_uc003mci.3_Missense_Mutation_p.G161R|BNIP1_uc003mck.3_Intron|BNIP1_uc003mcl.3_Intron	NM_001205	NP_001196	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kD interacting protein 1	118	Cytoplasmic (Potential).				anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TCTTCAGGGAGGAGATCTCTT	0.413000													28	40					0	0	1	0	0	
GPRIN1	114787	broad.mit.edu	37	5	176023843	176023843	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:176023843C>A	uc003meo.1	-	2	3168	c.2993G>T	c.(2992-2994)CGG>CTG	p.R998L		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	998	Interaction with GNAO1 (By similarity).					growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGAGCAGCACCGCGGCCGGCG	0.682000													8	21					0.000442599	0.000448719	1	1	0	
SLC34A1	6569	broad.mit.edu	37	5	176815279	176815279	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:176815279T>C	uc003mgk.3	+	8	943	c.842T>C	c.(841-843)CTG>CCG	p.L281P		NM_003052	NP_003043	Q06495	NPT2A_HUMAN	solute carrier family 34 (sodium phosphate),	281	Extracellular (Potential).				phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(1)	1	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCCCACAGCTGGACGAGTCT	0.587000													37	62					0	0	1	0	0	
DDX41	51428	broad.mit.edu	37	5	176940358	176940358	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:176940358A>C	uc003mho.2	-	11	1247	c.1226T>G	c.(1225-1227)ATC>AGC	p.I409S	DOK3_uc003mhi.3_5'Flank|DOK3_uc003mhj.3_5'Flank|DOK3_uc003mhl.2_5'Flank|DDX41_uc003mhm.2_Missense_Mutation_p.I189S|DDX41_uc003mhn.2_Missense_Mutation_p.I278S|DDX41_uc003mhp.2_Missense_Mutation_p.I278S|DDX41_uc003mhq.1_Missense_Mutation_p.I189S	NM_016222	NP_057306	Q9UJV9	DDX41_HUMAN	DEAD-box protein abstrakt	409	Helicase C-terminal.				apoptosis|multicellular organismal development	catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|zinc ion binding				0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.191)			GCCCACCTGGATGACATCCAG	0.597000													41	81					0	0	1	0	0	
ZFP2	80108	broad.mit.edu	37	5	178359024	178359024	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:178359024C>T	uc003mjn.1	+	5	1219	c.710C>T	c.(709-711)ACA>ATA	p.T237I	ZFP2_uc010jky.2_Missense_Mutation_p.T237I|ZFP2_uc010jkx.1_Missense_Mutation_p.T237I	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		AGAACTCATACAGGAGAAAAA	0.373000													36	35					0	0	1	0	0	
ZNF354C	30832	broad.mit.edu	37	5	178506224	178506224	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:178506224G>T	uc003mju.2	+	5	906	c.791G>T	c.(790-792)AGA>ATA	p.R264I		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	264	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		TCTCATCAGAGAATTCATACT	0.388000													34	37					2.20474e-14	2.33316e-14	1	1	0	
ADAMTS2	9509	broad.mit.edu	37	5	178563003	178563003	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:178563003G>A	uc003mjw.2	-	13	1992	c.1992C>T	c.(1990-1992)ACC>ACT	p.T664T		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	664	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCACCTCCCCGGTCTCCCTGG	0.627000													47	68					0	0	1	0	0	
MAML1	9794	broad.mit.edu	37	5	179201504	179201504	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:179201504A>G	uc003mkm.2	+	5	2940	c.2677A>G	c.(2677-2679)ATG>GTG	p.M893V	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	893					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATGGCTCCCATGAGCTCAGC	0.637000													13	25					0	0	1	0	0	
TRIM41	90933	broad.mit.edu	37	5	180661180	180661180	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:180661180T>G	uc003mne.1	+	6	1992	c.1298T>G	c.(1297-1299)CTG>CGG	p.L433R	TRIM41_uc003mnc.1_3'UTR|TRIM41_uc003mnd.1_Missense_Mutation_p.L433R|TRIM41_uc003mnf.1_RNA|TRIM41_uc003mng.1_Missense_Mutation_p.L13R	NM_033549	NP_291027	Q8WV44	TRI41_HUMAN	tripartite motif-containing 41 isoform 1	433	B30.2/SPRY.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding				0	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAAGTGGACCTGACGCTGGAC	0.667000													22	54					0	0	1	0	0	
DUSP22	56940	broad.mit.edu	37	6	335143	335143	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:335143G>A	uc003msx.2	+	4	607	c.168G>A	c.(166-168)GCG>GCA	p.A56A	DUSP22_uc011dhn.1_Silent_p.A56A|DUSP22_uc003msy.1_Silent_p.A13A	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	56					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		TCCCAGCAGCGGATTCACCAT	0.318000													8	58					0	0	1	0	0	
DUSP22	56940	broad.mit.edu	37	6	345898	345898	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:345898G>A	uc003msx.2	+	5	672	c.233G>A	c.(232-234)CGG>CAG	p.R78Q	DUSP22_uc011dhn.1_Missense_Mutation_p.R78Q|DUSP22_uc003msy.1_Missense_Mutation_p.R35Q	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	78	Tyrosine-protein phosphatase.				apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		CACGAGTGCCGGCTCCGCGGT	0.423000													6	56					0	0	1	0	0	
FAM50B	26240	broad.mit.edu	37	6	3850382	3850382	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:3850382C>T	uc003mvu.2	+	2	449	c.337C>T	c.(337-339)CGC>TGC	p.R113C		NM_012135	NP_036267	Q9Y247	FA50B_HUMAN	family with sequence similarity 50, member B	113						nucleus				pancreas(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				gcggcGCGAGCGCAAGCGTAA	0.532000													14	12					0	0	1	0	0	
DSP	1832	broad.mit.edu	37	6	7565711	7565711	+	Silent	SNP	C	T	T	rs121912992		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:7565711C>T	uc003mxp.1	+	7	1176	c.897C>T	c.(895-897)AGC>AGT	p.S299S	DSP_uc003mxq.1_Silent_p.S299S	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	299	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.		S -> R (in ARVD8).		cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		ACGACTGGAGCGACAAGAACA	0.547000													4	51					0	0	1	0	0	
DSP	1832	broad.mit.edu	37	6	7578041	7578041	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:7578041C>A	uc003mxp.1	+	21	3186	c.2907C>A	c.(2905-2907)ACC>ACA	p.T969T	DSP_uc003mxq.1_Silent_p.T969T	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	969	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CCTCATACACCTCAGGACTGG	0.428000													50	69					1.64573e-32	1.78201e-32	1	1	0	
CCDC90A	63933	broad.mit.edu	37	6	13801587	13801587	+	Missense_Mutation	SNP	G	A	A	rs145895773		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:13801587G>A	uc003nbd.2	-	4	802	c.674C>T	c.(673-675)GCG>GTG	p.A225V	CCDC90A_uc010jpf.2_RNA	NM_001031713	NP_001026883	Q96AQ8	CC90A_HUMAN	coiled-coil domain containing 90A precursor	225						integral to membrane|mitochondrion					0	Breast(50;0.0027)|Ovarian(93;0.0964)	all_hematologic(90;0.117)				TTTCACATTCGCAATCTGAGA	0.358000													30	20					0	0	1	0	0	
RBM24	221662	broad.mit.edu	37	6	17292117	17292117	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:17292117T>C	uc003nbz.3	+	4	482	c.478T>C	c.(478-480)TAC>CAC	p.Y160H	RBM24_uc003nby.3_3'UTR|RBM24_uc011dix.1_Missense_Mutation_p.Y102H|RBM24_uc003nca.2_Missense_Mutation_p.Y115H|RBM24_uc011diy.1_Silent_p.N73N|RBM24_uc011diz.1_Silent_p.N58N	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	160	Ala-rich.				cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			ATACGCACAATACTCAGCAgc	0.478000													40	20					0	0	1	0	0	
MRS2	57380	broad.mit.edu	37	6	24412566	24412566	+	Silent	SNP	C	T	T	rs148187811		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:24412566C>T	uc003neb.2	+	5	653	c.531C>T	c.(529-531)CTC>CTT	p.L177L	MRS2_uc003nea.2_Silent_p.L177L|MRS2_uc011djl.1_Silent_p.L180L|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Silent_p.L127L|MRS2_uc003nec.2_Silent_p.L54L	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	177	Mitochondrial matrix (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0						AGGGTCAACTCGTTACATACC	0.383000													37	19					0	0	1	0	0	
LRRC16A	55604	broad.mit.edu	37	6	25606376	25606376	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:25606376C>T	uc011djw.1	+	35	4098	c.3722C>T	c.(3721-3723)GCA>GTA	p.A1241V	LRRC16A_uc010jpx.2_Missense_Mutation_p.A1196V|LRRC16A_uc010jpy.2_Missense_Mutation_p.A1235V	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1241					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						AAAGCGGAAGCAGGCTCCAGG	0.567000													11	21					0	0	1	0	0	
SLC17A3	10786	broad.mit.edu	37	6	25845699	25845699	+	Missense_Mutation	SNP	C	T	T	rs114720409	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:25845699C>T	uc003nfi.3	-	11	1284	c.1174G>A	c.(1174-1176)GTT>ATT	p.V392I	SLC17A3_uc003nfk.3_Missense_Mutation_p.V470I	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	392	Helical; (Potential).				glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						AACAGGTTAACGGCAAACAGC	0.413000													32	60					0	0	1	0	0	
HIST1H1T	3010	broad.mit.edu	37	6	26108248	26108248	+	Missense_Mutation	SNP	C	T	T	rs142806773		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:26108248C>T	uc003ngj.2	-	1	117	c.74G>A	c.(73-75)CGA>CAA	p.R25Q		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	25					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						CTTCCTCCCTCGCTTCTTGGT	0.517000													22	25					0	0	1	0	0	
HIST1H1T	3010	broad.mit.edu	37	6	26108309	26108309	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:26108309C>T	uc003ngj.2	-	1	56	c.13G>A	c.(13-15)GTG>ATG	p.V5M		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	5					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						GCTGCAGGCACGGTTTCAGAC	0.542000													18	28					0	0	1	0	0	
MRPS18B	28973	broad.mit.edu	37	6	30590656	30590656	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:30590656C>A	uc003nqo.2	+	5	559	c.402C>A	c.(400-402)ATC>ATA	p.I134I	MRPS18B_uc011dml.1_Intron|MRPS18B_uc010jsd.1_Silent_p.I111I	NM_014046	NP_054765	Q9Y676	RT18B_HUMAN	mitochondrial ribosomal protein S18B precursor	134					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			ovary(1)	1						CGGGTATCATCTTCTATGCTC	0.498000													17	39					6.49762e-13	6.84434e-13	1	1	0	
DDR1	780	broad.mit.edu	37	6	30860096	30860096	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:30860096G>A	uc003nrr.2	+	9	1135	c.876G>A	c.(874-876)ACG>ACA	p.T292T	DDR1_uc010jse.2_Silent_p.T292T|DDR1_uc003nrq.2_Silent_p.T292T|DDR1_uc003nrs.2_Silent_p.T292T|DDR1_uc003nrt.2_Silent_p.T292T|DDR1_uc011dms.1_Silent_p.T310T|DDR1_uc003nru.2_Silent_p.T292T|DDR1_uc003nrv.2_Silent_p.T292T|DDR1_uc003nrw.1_Silent_p.T91T|DDR1_uc003nry.1_5'Flank|DDR1_uc003nrx.1_5'Flank	NM_013993	NP_054699	Q08345	DDR1_HUMAN	discoidin domain receptor family, member 1	292	Extracellular (Potential).				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|central_nervous_system(3)|large_intestine(1)|ovary(1)	9					Imatinib(DB00619)	ACATGCACACGCTGGGAGCCC	0.672000													17	34					0	0	1	0	0	
VARS2	57176	broad.mit.edu	37	6	30883960	30883960	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:30883960G>A	uc003nsc.1	+	6	1237	c.605G>A	c.(604-606)CGG>CAG	p.R202Q	VARS2_uc003nsd.2_Missense_Mutation_p.R202Q|VARS2_uc011dmx.1_Missense_Mutation_p.R202Q|VARS2_uc011dmy.1_Missense_Mutation_p.R62Q|VARS2_uc011dmz.1_Missense_Mutation_p.R232Q|VARS2_uc011dna.1_Missense_Mutation_p.R202Q|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_5'Flank	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	202					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						TGGAAGGAACGGGGAGTGAGG	0.562000													24	37					0	0	1	0	0	
DPCR1	135656	broad.mit.edu	37	6	30920773	30920773	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:30920773G>A	uc003nsg.2	+	3	4061	c.4061G>A	c.(4060-4062)CGC>CAC	p.R1354H		NM_080870	NP_543146	Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	478	Cytoplasmic (Potential).					integral to membrane					0						CGGACACGCCGCACACTAACC	0.517000													18	32					0	0	1	0	0	
NFKBIL1	4795	broad.mit.edu	37	6	31526079	31526079	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:31526079C>T	uc003nub.2	+	4	956	c.837C>T	c.(835-837)GCC>GCT	p.A279A	NFKBIL1_uc011dnr.1_Silent_p.A241A|NFKBIL1_uc011dns.1_Silent_p.A256A|NFKBIL1_uc011dnt.1_RNA|NFKBIL1_uc003nuc.2_Silent_p.A264A	NM_005007	NP_004998	Q9UBC1	IKBL1_HUMAN	nuclear factor of kappa light polypeptide gene	279					cytoplasmic sequestering of transcription factor		protein binding				0						CAACCAGGGCCGGGCCCAGGG	0.706000													3	8					0	0	1	0	0	
BAT3	7917	broad.mit.edu	37	6	31619438	31619438	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:31619438C>T	uc003nvg.3	-	2	417	c.103G>A	c.(103-105)GCC>ACC	p.A35T	BAT3_uc003nvf.3_Missense_Mutation_p.A35T|BAT3_uc003nvh.3_Missense_Mutation_p.A35T|BAT3_uc003nvi.3_Missense_Mutation_p.A35T|BAT3_uc011dnw.1_Missense_Mutation_p.A35T|BAT3_uc011dnx.1_Missense_Mutation_p.A35T|BAT3_uc003nvj.1_Missense_Mutation_p.A35T|APOM_uc003nvk.2_5'Flank	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	35	Ubiquitin-like.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						CTCACCTGGGCCCCCACAATA	0.507000													31	41					0	0	1	0	0	
MSH5	4439	broad.mit.edu	37	6	31715180	31715180	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:31715180C>A	uc003nwv.1	+	10	862	c.783C>A	c.(781-783)TGC>TGA	p.C261*	MSH5_uc003nwt.1_Nonsense_Mutation_p.C278*|MSH5_uc003nwu.1_Nonsense_Mutation_p.C261*|MSH5_uc003nww.1_Nonsense_Mutation_p.C261*|MSH5_uc003nwx.1_Nonsense_Mutation_p.C278*|MSH5_uc011dof.1_5'UTR	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	261					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						TCAACAGATGCCACTGTAAGT	0.473000								Direct_reversal_of_damage|MMR					16	15					1.67942e-08	1.73695e-08	1	1	0	
TNXB	7148	broad.mit.edu	37	6	32020768	32020768	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:32020768C>T	uc003nzl.2	-	26	8990	c.8788G>A	c.(8788-8790)GCA>ACA	p.A2930T		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCTTCCTCTGCAGCTGAGAAG	0.647000													12	25					0	0	1	0	0	
TNXB	7148	broad.mit.edu	37	6	32035444	32035444	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:32035444C>T	uc003nzl.2	-	18	6740	c.6538G>A	c.(6538-6540)GTC>ATC	p.V2180I		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2252					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCACCCGTGACGCCCACAGCA	0.637000													12	24					0	0	1	0	0	
TNXB	7148	broad.mit.edu	37	6	32035620	32035620	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:32035620C>T	uc003nzl.2	-	18	6564	c.6362G>A	c.(6361-6363)CGC>CAC	p.R2121H		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2193	Fibronectin type-III 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGAGTCGAAGCGGCCCTGGGG	0.692000													28	43					0	0	1	0	0	
TNXB	7148	broad.mit.edu	37	6	32063940	32063940	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:32063940G>A	uc003nzl.2	-	3	1892	c.1690C>T	c.(1690-1692)CGA>TGA	p.R564*		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	564	EGF-like 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCGCGGCCTCGGCAGCCCCCG	0.682000													5	5					0	0	1	0	0	
NOTCH4	4855	broad.mit.edu	37	6	32172014	32172014	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:32172014G>A	uc003obb.2	-	19	3157	c.3018C>T	c.(3016-3018)GAC>GAT	p.D1006D	NOTCH4_uc003oba.2_5'Flank|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1006	Extracellular (Potential).|EGF-like 26.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ACTCGTCCACGTCTCCCTCAC	0.607000													20	26					0	0	1	0	0	
HLA-DRA	3122	broad.mit.edu	37	6	32407731	32407731	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:32407731G>A	uc003obh.2	+	1	85	c.4G>A	c.(4-6)GCC>ACC	p.A2T	HLA-DRA_uc003obi.2_Missense_Mutation_p.A2T	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	2					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						GAAGAAAATGGCCATAAGTGG	0.468000									T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|Kaposi_Sarcoma_Familial_Clustering_of				4	53					0	0	1	0	0	
ITPR3	3710	broad.mit.edu	37	6	33634933	33634933	+	Missense_Mutation	SNP	C	T	T	rs139434169	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:33634933C>T	uc011drk.1	+	15	1798	c.1579C>T	c.(1579-1581)CGT>TGT	p.R527C		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	527	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						GGCCCCGTTCCGTGAGAAGGG	0.592000													27	68					0	0	1	0	0	
ITPR3	3710	broad.mit.edu	37	6	33641396	33641396	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:33641396G>A	uc011drk.1	+	23	3176	c.2957G>A	c.(2956-2958)CGC>CAC	p.R986H		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	986	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CTGGATTACCGCATATCCTAC	0.542000													8	204					0	0	1	0	0	
ITPR3	3710	broad.mit.edu	37	6	33653503	33653503	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:33653503G>A	uc011drk.1	+	41	5785	c.5566G>A	c.(5566-5568)GAA>AAA	p.E1856K	ITPR3_uc003oey.2_5'Flank	NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1856	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CGAGGTGAGCGAACGTGTGCA	0.652000													25	51					0	0	1	0	0	
GRM4	2914	broad.mit.edu	37	6	34059859	34059859	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:34059859G>A	uc003oir.3	-	2	707	c.537C>T	c.(535-537)TAC>TAT	p.Y179Y	GRM4_uc011dsn.1_Silent_p.Y179Y|GRM4_uc010jvh.2_Silent_p.Y179Y|GRM4_uc010jvi.2_Intron|GRM4_uc010jvk.1_Silent_p.Y98Y|GRM4_uc011dsl.1_Silent_p.Y39Y|GRM4_uc003oiq.2_Silent_p.Y46Y|GRM4_uc011dsm.1_Silent_p.Y10Y	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	179	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	CTGTGGAGGCGTAGCTGATCT	0.652000													23	32					0	0	1	0	0	
GRM4	2914	broad.mit.edu	37	6	34100766	34100766	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:34100766G>A	uc003oir.3	-	1	678	c.508C>T	c.(508-510)CGC>TGC	p.R170C	GRM4_uc011dsn.1_Missense_Mutation_p.R170C|GRM4_uc010jvh.2_Missense_Mutation_p.R170C|GRM4_uc010jvi.2_5'UTR|GRM4_uc010jvk.1_Missense_Mutation_p.R89C	NM_000841	NP_000832	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4 precursor	170	Extracellular (Potential).				activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6					L-Glutamic Acid(DB00142)	TTGAAGAGGCGAAGGATGTTG	0.637000													14	25					0	0	1	0	0	
SCUBE3	222663	broad.mit.edu	37	6	35214016	35214016	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:35214016G>A	uc003okf.1	+	21	2792	c.2786G>A	c.(2785-2787)CGA>CAA	p.R929Q	SCUBE3_uc003okg.1_Missense_Mutation_p.R928Q|SCUBE3_uc003okh.1_Missense_Mutation_p.R816Q	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	929					protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						GACATTGTGCGAGATGGCCGG	0.418000													34	81					0	0	1	0	0	
PPARD	5467	broad.mit.edu	37	6	35392205	35392205	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:35392205G>A	uc003okm.2	+	7	1036	c.727G>A	c.(727-729)GTG>ATG	p.V243M	PPARD_uc003okl.2_Missense_Mutation_p.V243M|PPARD_uc003okn.2_Missense_Mutation_p.V243M|PPARD_uc011dtb.1_Missense_Mutation_p.V204M|PPARD_uc011dtc.1_Missense_Mutation_p.V145M	NM_006238	NP_006229	Q03181	PPARD_HUMAN	peroxisome proliferative activated receptor,	243					apoptosis|axon ensheathment|cholesterol metabolic process|decidualization|embryo implantation|fatty acid beta-oxidation|fatty acid transport|generation of precursor metabolites and energy|glucose metabolic process|glucose transport|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|linoleic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1					Icosapent(DB00159)|Sulindac(DB00605)|Treprostinil(DB00374)	GGAGATCAGCGTGCACGTCTT	0.587000													20	43					0	0	1	0	0	
C6orf81	221481	broad.mit.edu	37	6	35704936	35704936	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:35704936C>T	uc003ola.2	+	1	78	c.51C>T	c.(49-51)AGC>AGT	p.S17S	LOC285847_uc010jvy.1_5'Flank|C6orf81_uc003olb.1_Silent_p.S17S	NM_145028	NP_659465	Q5T9G4	CF081_HUMAN	hypothetical protein LOC221481	17							binding			ovary(1)	1						TCCGCAAAAGCGTAGTCAGCC	0.592000											OREG0017379	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	43					0	0	1	0	0	
KCTD20	222658	broad.mit.edu	37	6	36442765	36442765	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:36442765G>A	uc003ome.2	+	3	751	c.360G>A	c.(358-360)ACG>ACA	p.T120T	KCTD20_uc011dtm.1_Intron|KCTD20_uc011dtn.1_Intron|KCTD20_uc010jwk.2_Intron|KCTD20_uc011dto.1_Intron	NM_173562	NP_775833	Q7Z5Y7	KCD20_HUMAN	potassium channel tetramerisation domain	120	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2						AGAAAGTGACGCTTCTTGTAG	0.423000													37	66					0	0	1	0	0	
CPNE5	57699	broad.mit.edu	37	6	36710078	36710078	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:36710078C>T	uc003omr.1	-	21	1816	c.1749G>A	c.(1747-1749)ACG>ACA	p.T583T	CPNE5_uc003omp.1_Silent_p.T291T|CPNE5_uc010jwn.1_Silent_p.T233T|CPNE5_uc003omq.1_Silent_p.T233T	NM_020939	NP_065990	Q9HCH3	CPNE5_HUMAN	copine V	583										skin(1)	1						ACGCAGGGGGCGTGCGGGCTG	0.692000													8	58					0	0	1	0	0	
ZFAND3	60685	broad.mit.edu	37	6	38120035	38120035	+	Missense_Mutation	SNP	G	A	A	rs112599440		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:38120035G>A	uc003onx.2	+	6	969	c.554G>A	c.(553-555)CGC>CAC	p.R185H		NM_021943	NP_068762	Q9H8U3	ZFAN3_HUMAN	zinc finger, AN1-type domain 3	185	AN1-type.						DNA binding|zinc ion binding			ovary(1)	1						ATGTTACATCGCCTCCCCGAG	0.572000													58	89					0	0	1	0	0	
BTBD9	114781	broad.mit.edu	37	6	38548022	38548022	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:38548022G>A	uc003ooa.3	-	6	1582	c.1006C>T	c.(1006-1008)CGG>TGG	p.R336W	BTBD9_uc003ony.3_Missense_Mutation_p.R268W|BTBD9_uc010jwv.2_Missense_Mutation_p.R268W|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.R336W	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	336					cell adhesion						0						AAGAGTATCCGTATGTGATTG	0.418000													26	42					0	0	1	0	0	
GLO1	2739	broad.mit.edu	37	6	38654677	38654677	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:38654677A>T	uc003ooc.2	-	2	280	c.158T>A	c.(157-159)CTT>CAT	p.L53H		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	53					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	CGTCATTCCAAGAACTCTAGT	0.328000													25	35					0	0	1	0	0	
KCNK17	89822	broad.mit.edu	37	6	39267230	39267230	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:39267230G>A	uc003ooo.2	-	5	1112	c.972C>T	c.(970-972)CAC>CAT	p.H324H	KCNK17_uc003oop.2_3'UTR	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	324	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						aGCCTGCAGCGTGAGCAGAAG	0.328000													12	25					0	0	1	0	0	
KCNK17	89822	broad.mit.edu	37	6	39267459	39267459	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:39267459C>A	uc003ooo.2	-	5	883	c.743G>T	c.(742-744)TGG>TTG	p.W248L	KCNK17_uc003oop.2_3'UTR	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	248	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						AAAGAGGATCCACAGGGACAC	0.572000													45	95					4.18559e-23	4.4919e-23	1	1	0	
DAAM2	23500	broad.mit.edu	37	6	39856480	39856480	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:39856480C>T	uc003oow.2	+	17	2242	c.2086C>T	c.(2086-2088)CGG>TGG	p.R696W	DAAM2_uc003oox.2_Missense_Mutation_p.R696W|uc003ooz.1_5'Flank	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	696	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CGAGGAGATCCGGCAGGCCAT	0.557000													17	26					0	0	1	0	0	
TREM1	54210	broad.mit.edu	37	6	41250435	41250435	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:41250435T>C	uc003oqf.1	-	2	168	c.104A>G	c.(103-105)CAG>CGG	p.Q35R	TREM1_uc003oqg.1_Missense_Mutation_p.Q35R	NM_018643	NP_061113	Q9NP99	TREM1_HUMAN	triggering receptor expressed on myeloid cells 1	35	Extracellular (Potential).|Ig-like V-type.			Q -> K (in Ref. 3; AAL74018).	blood coagulation|humoral immune response|intracellular signal transduction|leukocyte migration	extracellular region|integral to membrane|intracellular|plasma membrane	receptor activity			breast(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)				Glutathione(DB00143)	ATCCAGGGTCTGCCCCTCTTT	0.458000													50	73					0	0	1	0	0	
TRERF1	55809	broad.mit.edu	37	6	42236784	42236784	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:42236784C>T	uc003osd.2	-	5	1108	c.545G>A	c.(544-546)CGC>CAC	p.R182H	TRERF1_uc011duq.1_Missense_Mutation_p.R182H|TRERF1_uc003osb.2_Missense_Mutation_p.R21H|TRERF1_uc003osc.2_Missense_Mutation_p.R21H|TRERF1_uc003ose.2_Missense_Mutation_p.R182H	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	182					cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CAGCAGCTGGCGGAGAGCACT	0.602000													6	98					0	0	1	0	0	
UBR2	23304	broad.mit.edu	37	6	42585024	42585024	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:42585024G>A	uc011dur.1	+	11	1229	c.1229G>A	c.(1228-1230)CGA>CAA	p.R410Q	UBR2_uc011dus.1_Intron|UBR2_uc010jxv.1_5'UTR|UBR2_uc003osh.2_Intron|UBR2_uc003osf.2_Intron	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	410					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GATCACGAGCGAGCAGTGTCG	0.463000													39	58					0	0	1	0	0	
PRPH2	5961	broad.mit.edu	37	6	42689775	42689775	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:42689775G>A	uc003osk.2	-	1	584	c.298C>T	c.(298-300)CCG>TCG	p.P100S		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	100	Helical; (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			GCCAGGTACGGCTTCAGCCAG	0.577000													26	43					0	0	1	0	0	
CUL9	23113	broad.mit.edu	37	6	43153844	43153844	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:43153844A>G	uc003ouk.2	+	4	977	c.902A>G	c.(901-903)GAG>GGG	p.E301G	CUL9_uc003ouj.1_Missense_Mutation_p.E301G|CUL9_uc003oul.2_Missense_Mutation_p.E301G|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_5'Flank	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	301					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CGGGAACTGGAGTTCAGCATG	0.612000													5	85					0	0	1	0	0	
ZNF318	24149	broad.mit.edu	37	6	43310528	43310528	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:43310528G>A	uc003oux.2	-	7	3240	c.3162C>T	c.(3160-3162)CCC>CCT	p.P1054P	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1054					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			AAGCAGCAGTGGGCTGATCCA	0.463000													41	56					0	0	1	0	0	
AARS2	57505	broad.mit.edu	37	6	44272877	44272877	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:44272877G>A	uc010jza.1	-	11	1496	c.1493C>T	c.(1492-1494)GCG>GTG	p.A498V	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	498					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CTCCCCAAGCGCATGGACATC	0.607000											OREG0017473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	68					0	0	1	0	0	
RUNX2	860	broad.mit.edu	37	6	45390581	45390581	+	Nonsense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:45390581G>T	uc011dvx.1	+	3	520	c.310G>T	c.(310-312)GAG>TAG	p.E104*	RUNX2_uc011dvy.1_Nonsense_Mutation_p.E104*|RUNX2_uc003oxt.2_Nonsense_Mutation_p.E90*	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	runt-related transcription factor 2 isoform a	104	Runt.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3						CACCATGGTGGAGATCATCGC	0.488000													12	18					7.03913e-09	7.29497e-09	1	1	0	
PAQR8	85315	broad.mit.edu	37	6	52268150	52268150	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:52268150C>A	uc003pao.3	+	2	313	c.139C>A	c.(139-141)CGG>AGG	p.R47R		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	47	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					CCAGCTCTTCCGGGAGCCTTA	0.622000													29	50					2.4375e-19	2.60499e-19	1	1	0	
FBXO9	26268	broad.mit.edu	37	6	52957325	52957325	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:52957325G>A	uc003pbo.2	+	8	833	c.782G>A	c.(781-783)CGG>CAG	p.R261Q	FBXO9_uc003pbk.2_Missense_Mutation_p.R217Q|FBXO9_uc003pbl.2_Missense_Mutation_p.R251Q|FBXO9_uc003pbm.2_Missense_Mutation_p.R141Q|FBXO9_uc003pbn.2_Missense_Mutation_p.R141Q	NM_012347	NP_036479	Q9UK97	FBX9_HUMAN	F-box only protein 9 isoform 1	261						ubiquitin ligase complex	ubiquitin-protein ligase activity			pancreas(1)	1	Lung NSC(77;0.103)					TTTTTAGAACGGCCTCGTGTT	0.413000													48	47					0	0	1	0	0	
GCLC	2729	broad.mit.edu	37	6	53385602	53385602	+	Silent	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:53385602A>C	uc003pbw.1	-	3	808	c.420T>G	c.(418-420)GCT>GCG	p.A140A	GCLC_uc003pbx.2_Silent_p.A140A	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	140					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	TTGTGCAAAGAGCCTGATTTT	0.453000													93	122					0	0	1	0	0	
KIAA1586	57691	broad.mit.edu	37	6	56917539	56917539	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:56917539T>C	uc003pdj.2	+	4	412	c.242T>C	c.(241-243)GTG>GCG	p.V81A	KIAA1586_uc011dxm.1_Missense_Mutation_p.V54A	NM_020931	NP_065982	Q9HCI6	K1586_HUMAN	hypothetical protein LOC57691	81							nucleic acid binding				0	Lung NSC(77;0.0969)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTTTTAAATGTGAAGAAGGTG	0.308000													18	28					0	0	1	0	0	
ZNF451	26036	broad.mit.edu	37	6	57012049	57012049	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:57012049G>A	uc003pdm.1	+	10	1390	c.1166G>A	c.(1165-1167)CGA>CAA	p.R389Q	ZNF451_uc003pdl.2_Missense_Mutation_p.R389Q|ZNF451_uc003pdn.1_Missense_Mutation_p.R389Q|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Missense_Mutation_p.R389Q	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	389					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CACAAAGTCCGAGTCATTAAC	0.398000													26	36					0	0	1	0	0	
KHDRBS2	202559	broad.mit.edu	37	6	62604604	62604604	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:62604604C>T	uc003peg.2	-	6	993	c.746G>A	c.(745-747)GGG>GAG	p.G249E		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	249	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TGTTGGTGCCCCCCGGGCTCG	0.552000													32	33					0	0	1	0	0	
DDX43	55510	broad.mit.edu	37	6	74117732	74117732	+	Nonsense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:74117732A>T	uc003pgw.2	+	9	1431	c.1087A>T	c.(1087-1089)AAA>TAA	p.K363*	DDX43_uc011dyn.1_RNA	NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	363	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						AGAAGAGCTTAAAAAAGGTGT	0.323000													20	42					0	0	1	0	0	
COL12A1	1303	broad.mit.edu	37	6	75799910	75799910	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:75799910C>T	uc003phs.2	-	63	9023	c.8857G>A	c.(8857-8859)GCA>ACA	p.A2953T	COL12A1_uc003pht.2_Missense_Mutation_p.A1789T	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2953	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CTGGCTCCTGCGCTACCAGGA	0.622000													83	169					0	0	1	0	0	
COL12A1	1303	broad.mit.edu	37	6	75834938	75834938	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:75834938A>G	uc003phs.2	-	40	6678	c.6512T>C	c.(6511-6513)TTA>TCA	p.L2171S	COL12A1_uc003pht.2_Missense_Mutation_p.L1007S	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2171	Fibronectin type-III 17.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GAGATTGTGTAAGGTATATGA	0.413000													20	30					0	0	1	0	0	
COL12A1	1303	broad.mit.edu	37	6	75890672	75890672	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:75890672T>C	uc003phs.2	-	11	2313	c.2147A>G	c.(2146-2148)GAG>GGG	p.E716G	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_Missense_Mutation_p.E374G	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	716	Fibronectin type-III 3.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GGTGGTCTCCTCTCCAGCTAA	0.448000													41	90					0	0	1	0	0	
MYO6	4646	broad.mit.edu	37	6	76623869	76623869	+	Missense_Mutation	SNP	C	T	T	rs146419641	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:76623869C>T	uc003pih.1	+	34	3808	c.3529C>T	c.(3529-3531)CGC>TGC	p.R1177C	MYO6_uc003pii.1_Missense_Mutation_p.R1154C|MYO6_uc003pij.1_Missense_Mutation_p.R125C	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1186					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		CCCATTCATCCGCCCTGCCGA	0.522000													56	96					0	0	1	0	0	
MYO6	4646	broad.mit.edu	37	6	76624686	76624686	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:76624686G>A	uc003pih.1	+	35	4094	c.3815G>A	c.(3814-3816)CGG>CAG	p.R1272Q	MYO6_uc003pii.1_Missense_Mutation_p.R1249Q|MYO6_uc003pij.1_Missense_Mutation_p.R220Q	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	1281					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AGACAGGCTCGGCCCACCTAT	0.517000													9	15					0	0	1	0	0	
IMPG1	3617	broad.mit.edu	37	6	76713645	76713645	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:76713645G>A	uc003pik.1	-	11	1288	c.1158C>T	c.(1156-1158)GCC>GCT	p.A386A		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	386					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CAGGACCAAAGGCTGGCAGTG	0.388000													23	41					0	0	1	0	0	
TBX18	9096	broad.mit.edu	37	6	85447043	85447043	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:85447043C>T	uc003pkl.1	-	8	1184	c.1184G>A	c.(1183-1185)TGC>TAC	p.C395Y	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	395					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.C395F(1)		ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AGGAGAGGAGCAAGAGGAGCC	0.572000													25	38					0	0	1	0	0	
AKIRIN2	55122	broad.mit.edu	37	6	88391420	88391420	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:88391420T>C	uc003pmk.2	-	2	880	c.297A>G	c.(295-297)GAA>GAG	p.E99E		NM_018064	NP_060534	Q53H80	AKIR2_HUMAN	akirin 2	99					innate immune response|transcription, DNA-dependent	transcriptional repressor complex					0						GGAAACTCGTTTCTAAATGTC	0.353000													8	21					0	0	1	0	0	
ZBTB24	9841	broad.mit.edu	37	6	109787639	109787639	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:109787639G>A	uc003ptl.1	-	7	1677	c.1509C>T	c.(1507-1509)GAC>GAT	p.D503D	MICAL1_uc011eaq.1_5'Flank|ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Silent_p.D447D|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	503	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		CCTTCAAGTTGTCTAAGCGAG	0.458000													39	74					0	0	1	0	0	
ZBTB24	9841	broad.mit.edu	37	6	109796613	109796613	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:109796613C>T	uc003ptl.1	-	5	1445	c.1277G>A	c.(1276-1278)CGA>CAA	p.R426Q	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Missense_Mutation_p.R370Q|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	426	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		TGTGTGTGTTCGCAGATGTTT	0.468000													29	54					0	0	1	0	0	
TUBE1	51175	broad.mit.edu	37	6	112400892	112400892	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:112400892G>A	uc003pvq.2	-	6	506	c.392C>T	c.(391-393)TCG>TTG	p.S131L	TUBE1_uc003pvr.2_Missense_Mutation_p.S56L	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	131					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		GTGCTCTGCCGACTTTCTGAA	0.373000													41	55					0	0	1	0	0	
ROS1	6098	broad.mit.edu	37	6	117642517	117642517	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:117642517T>A	uc003pxp.1	-	35	5881	c.5682A>T	c.(5680-5682)GAA>GAT	p.E1894D	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Missense_Mutation_p.E206D	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1894	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CTGTCACCCCTTCCTTGGCAC	0.398000			T	GOPC|ROS1	glioblastoma|NSCLC								64	112					0	0	1	0	0	
ROS1	6098	broad.mit.edu	37	6	117662759	117662759	+	Missense_Mutation	SNP	C	T	T	rs141448347		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:117662759C>T	uc003pxp.1	-	29	4905	c.4706G>A	c.(4705-4707)CGG>CAG	p.R1569Q	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1569	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GGTGTCTGACCGCACAGTTGT	0.428000			T	GOPC|ROS1	glioblastoma|NSCLC								21	44					0	0	1	0	0	
NUS1	116150	broad.mit.edu	37	6	118014204	118014204	+	Splice_Site	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:118014204G>T	uc003pxw.2	+	2	633	c.416_splice	c.e2-1	p.G139_splice		NM_138459	NP_612468	Q96E22	NGBR_HUMAN	nuclear undecaprenyl pyrophosphate synthase 1						angiogenesis|cell differentiation	integral to membrane	receptor activity|transferase activity, transferring alkyl or aryl (other than methyl) groups			central_nervous_system(1)	1		all_cancers(87;0.0395)|all_epithelial(87;0.0301)		GBM - Glioblastoma multiforme(226;0.02)|OV - Ovarian serous cystadenocarcinoma(136;0.115)|all cancers(137;0.146)		CTTTTTTAAAGGTATTTTCAA	0.318000													11	18					3.86212e-05	3.92521e-05	1	1	0	
HSF2	3298	broad.mit.edu	37	6	122753116	122753116	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:122753116C>T	uc003pyu.2	+	13	1549	c.1362C>T	c.(1360-1362)CTC>CTT	p.L454L	HSF2_uc003pyv.2_Silent_p.L436L	NM_004506	NP_004497	Q03933	HSF2_HUMAN	heat shock transcription factor 2 isoform a	454					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		TTGCATTCCTCGATGGGAACC	0.418000													71	91					0	0	1	0	0	
LAMA2	3908	broad.mit.edu	37	6	129511427	129511427	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:129511427C>T	uc003qbn.2	+	11	1650	c.1545C>T	c.(1543-1545)TGC>TGT	p.C515C	LAMA2_uc003qbo.2_Silent_p.C515C	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	515	Laminin EGF-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGAAAGGCTGCGATGAGTGTT	0.443000													24	29					0	0	1	0	0	
KIAA1244	57221	broad.mit.edu	37	6	138619829	138619829	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:138619829T>C	uc003qhu.2	+	22	3735	c.3735T>C	c.(3733-3735)AAT>AAC	p.N1245N		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1245					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CTGACTGGAATGAGCCACCTC	0.478000													12	23					0	0	1	0	0	
LATS1	9113	broad.mit.edu	37	6	150004891	150004891	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:150004891G>A	uc003qmu.1	-	4	1882	c.1334C>T	c.(1333-1335)CCG>CTG	p.P445L	LATS1_uc010kif.1_Missense_Mutation_p.P340L|LATS1_uc003qmv.1_Missense_Mutation_p.P445L|LATS1_uc003qmw.2_Missense_Mutation_p.P445L|LATS1_uc010kig.1_Missense_Mutation_p.P340L	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	445					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		CCCACTGCTCGGGGATGACTG	0.423000													97	168					0	0	1	0	0	
PLEKHG1	57480	broad.mit.edu	37	6	151161247	151161247	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:151161247G>A	uc003qny.1	+	17	3685	c.3373G>A	c.(3373-3375)GCA>ACA	p.A1125T	PLEKHG1_uc011eem.1_Missense_Mutation_p.A1184T	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1125					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		GCAATTGTCCGCAGCTTGCTC	0.498000													42	58					0	0	1	0	0	
MTHFD1L	25902	broad.mit.edu	37	6	151355726	151355726	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:151355726A>G	uc003qob.2	+	25	2952	c.2684A>G	c.(2683-2685)TAC>TGC	p.Y895C	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Missense_Mutation_p.Y896C|MTHFD1L_uc003qoc.2_Missense_Mutation_p.Y843C	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	895	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		ATAGATCGTTACACTCAACAG	0.418000													15	26					0	0	1	0	0	
RMND1	55005	broad.mit.edu	37	6	151766824	151766824	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:151766824G>A	uc003qoi.2	-	2	303	c.123C>T	c.(121-123)TGC>TGT	p.C41C	RMND1_uc011eeq.1_5'Flank|RMND1_uc003qoj.2_Silent_p.C41C|RMND1_uc011eer.1_Silent_p.C41C	NM_017909	NP_060379	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog	41											0		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		TCAGTGTGCTGCATGTTGTAT	0.378000													33	54					0	0	1	0	0	
ARID1B	57492	broad.mit.edu	37	6	157528929	157528929	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:157528929C>T	uc003qqn.2	+	20	6752	c.6600C>T	c.(6598-6600)CAC>CAT	p.H2200H	ARID1B_uc003qqo.2_Silent_p.H2160H|ARID1B_uc003qqp.2_Silent_p.H2147H	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2205					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		TCCTTTTGCACGAGGGCCGGT	0.527000													57	87					0	0	1	0	0	
TULP4	56995	broad.mit.edu	37	6	158924181	158924181	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:158924181C>T	uc003qrf.2	+	13	4843	c.3486C>T	c.(3484-3486)GAC>GAT	p.D1162D	TULP4_uc003qrg.2_Intron	NM_020245	NP_064630	Q9NRJ4	TULP4_HUMAN	tubby like protein 4 isoform 1	1162					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		AGCACCTGGACGTGTCCCGAC	0.557000													41	73					0	0	1	0	0	
RSPH3	83861	broad.mit.edu	37	6	159401904	159401904	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:159401904G>A	uc003qrx.2	-	6	1377	c.1187C>T	c.(1186-1188)GCC>GTC	p.A396V	RSPH3_uc010kju.2_Missense_Mutation_p.A300V	NM_031924	NP_114130	Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog	396										ovary(1)|skin(1)	2		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		TGCTCGGGCGGCGATTTTTTG	0.483000													24	41					0	0	1	0	0	
SLC22A3	6581	broad.mit.edu	37	6	160864677	160864677	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:160864677G>A	uc003qti.2	+	9	1440	c.1413G>A	c.(1411-1413)TCG>TCA	p.S471S	SLC22A3_uc011efx.1_RNA	NM_021977	NP_068812	O75751	S22A3_HUMAN	solute carrier family 22 member 3	471	Helical; (Potential).					integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		TCGGAGTTTCGCTCTGTTCAG	0.378000													16	29					0	0	1	0	0	
LPAL2	80350	broad.mit.edu	37	6	160906847	160906847	+	RNA	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:160906847G>A	uc003qtj.2	-	5		c.850C>T			LPAL2_uc011efy.1_RNA	NR_028093				Homo sapiens cDNA FLJ43922 fis, clone TESTI4012406.												0		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		AAAGACGTACGCATTTGGGTA	0.468000													97	172					0	0	1	0	0	
UNC93A	54346	broad.mit.edu	37	6	167717522	167717522	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:167717522G>A	uc003qvq.2	+	5	916	c.741G>A	c.(739-741)TCG>TCA	p.S247S	UNC93A_uc003qvr.2_Silent_p.S205S	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	247						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ctttactgtcgactttcaagc	0.294000													28	51					0	0	1	0	0	
TBP	6908	broad.mit.edu	37	6	170871058	170871058	+	Silent	SNP	G	A	A	rs113440919		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:170871058G>A	uc003qxt.2	+	3	466	c.234G>A	c.(232-234)CAG>CAA	p.Q78Q	TBP_uc003qxu.2_Silent_p.Q78Q|TBP_uc011ehf.1_Silent_p.Q58Q|TBP_uc011ehg.1_Silent_p.Q78Q	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	78	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.164000													4	33					0	0	1	0	0	
C7orf50	84310	broad.mit.edu	37	7	1049627	1049627	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:1049627G>A	uc003sju.2	-	3	352	c.282C>T	c.(280-282)GCC>GCT	p.A94A	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Silent_p.A94A|C7orf50_uc011jvu.1_Silent_p.A94A	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	94							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		CCGAGCGCCTGGCAGGCGGGT	0.667000													5	5					0	0	1	0	0	
SDK1	221935	broad.mit.edu	37	7	4050642	4050642	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:4050642A>G	uc003smx.2	+	15	2315	c.2176A>G	c.(2176-2178)ACA>GCA	p.T726A	SDK1_uc010kso.2_Missense_Mutation_p.T2A	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	726	Fibronectin type-III 1.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CCCTGAGATGACAGGCGTCAC	0.527000													12	20					0	0	1	0	0	
SDK1	221935	broad.mit.edu	37	7	4247845	4247845	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:4247845A>C	uc003smx.2	+	37	5468	c.5329A>C	c.(5329-5331)AGC>CGC	p.S1777R	SDK1_uc010kso.2_Missense_Mutation_p.S1033R|SDK1_uc003smy.2_Missense_Mutation_p.S264R	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1777	Fibronectin type-III 11.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTACCTGGTCAGCATATCAGC	0.607000													21	21					0	0	1	0	0	
TNRC18	84629	broad.mit.edu	37	7	5372608	5372608	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:5372608C>T	uc003soi.3	-	19	6141	c.5792G>A	c.(5791-5793)CGG>CAG	p.R1931Q		NM_001080495	NP_001073964	O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1931							DNA binding				0		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CTTCTTGGGCCGCAGCAGCCC	0.721000													4	2					0	0	1	0	0	
RNF216	54476	broad.mit.edu	37	7	5781254	5781254	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:5781254C>T	uc003soy.1	-	4	413	c.223G>A	c.(223-225)GGT>AGT	p.G75S	RNF216_uc010ksz.1_5'UTR|RNF216_uc010kta.1_Intron|RNF216_uc011jwj.1_Intron|RNF216_uc003sox.1_Missense_Mutation_p.G132S	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	75					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		AGAAATTCACCGTAGTCATCC	0.458000													48	89					0	0	1	0	0	
DAGLB	221955	broad.mit.edu	37	7	6449620	6449620	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:6449620C>T	uc003sqa.2	-	15	2037	c.1867G>A	c.(1867-1869)GAA>AAA	p.E623K	DAGLB_uc003spy.2_Missense_Mutation_p.E169K|DAGLB_uc003spz.2_Missense_Mutation_p.E320K|DAGLB_uc011jwt.1_Missense_Mutation_p.E437K|DAGLB_uc011jwu.1_Missense_Mutation_p.E494K|DAGLB_uc003sqb.2_Missense_Mutation_p.E342K|DAGLB_uc003sqc.2_Missense_Mutation_p.E342K|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Missense_Mutation_p.E582K	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	623	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		AATTCCGCTTCGTGTGACCAC	0.592000													38	52					0	0	1	0	0	
DAGLB	221955	broad.mit.edu	37	7	6456287	6456287	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:6456287G>A	uc003sqa.2	-	11	1568	c.1398C>T	c.(1396-1398)TAC>TAT	p.Y466Y	DAGLB_uc003spy.2_Silent_p.Y12Y|DAGLB_uc003spz.2_Silent_p.Y163Y|DAGLB_uc011jwt.1_Silent_p.Y280Y|DAGLB_uc011jwu.1_Silent_p.Y337Y|DAGLB_uc003sqb.2_Silent_p.Y185Y|DAGLB_uc003sqc.2_Silent_p.Y185Y|DAGLB_uc011jwv.1_Intron|DAGLB_uc003sqd.3_Silent_p.Y425Y|DAGLB_uc011jww.1_RNA	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	466	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GGGAGAAGGCGTAGCACCTGA	0.607000													48	74					0	0	1	0	0	
HDAC9	9734	broad.mit.edu	37	7	18688172	18688172	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:18688172C>T	uc003suh.2	+	10	1365	c.1324C>T	c.(1324-1326)CGT>TGT	p.R442C	HDAC9_uc003sue.2_Missense_Mutation_p.R442C|HDAC9_uc011jyd.1_Missense_Mutation_p.R442C|HDAC9_uc003sui.2_Missense_Mutation_p.R445C|HDAC9_uc003suj.2_Missense_Mutation_p.R401C|HDAC9_uc011jya.1_Missense_Mutation_p.R439C|HDAC9_uc003sua.1_Missense_Mutation_p.R420C|HDAC9_uc011jyb.1_Missense_Mutation_p.R398C|HDAC9_uc003sud.1_Missense_Mutation_p.R442C|HDAC9_uc011jyc.1_Missense_Mutation_p.R401C|HDAC9_uc003suf.1_Missense_Mutation_p.R473C|HDAC9_uc010kud.1_Missense_Mutation_p.R445C|HDAC9_uc011jye.1_Missense_Mutation_p.R414C|HDAC9_uc011jyf.1_Missense_Mutation_p.R365C|HDAC9_uc010kue.1_Missense_Mutation_p.R185C	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	442					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CAAATTGCCCCGTCACAGACC	0.488000													28	49					0	0	1	0	0	
MACC1	346389	broad.mit.edu	37	7	20197933	20197933	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:20197933A>T	uc003sus.3	-	5	2360	c.2051T>A	c.(2050-2052)ATT>AAT	p.I684N	MACC1_uc010kug.2_Missense_Mutation_p.I684N	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5	684					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						GTCTGCTTGAATTTGATCAAA	0.348000													14	40					0	0	1	0	0	
SP4	6671	broad.mit.edu	37	7	21469089	21469089	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:21469089G>A	uc003sva.2	+	3	487	c.306G>A	c.(304-306)TGG>TGA	p.W102*	SP4_uc003svb.2_5'UTR	NM_003112	NP_003103	Q02446	SP4_HUMAN	Sp4 transcription factor	102					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(3)|skin(2)	5						GAAACGCTTGGCAACTTGTTG	0.428000													24	39					0	0	1	0	0	
GPNMB	10457	broad.mit.edu	37	7	23300296	23300296	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:23300296A>G	uc003swc.2	+	6	1083	c.922A>G	c.(922-924)ACC>GCC	p.T308A	GPNMB_uc003swb.2_Missense_Mutation_p.T308A|GPNMB_uc011jyy.1_Missense_Mutation_p.T250A|GPNMB_uc011jyz.1_Missense_Mutation_p.T209A	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	308	PKD.|Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			GCTCAATGGAACCTTCAGCCT	0.483000													56	111					0	0	1	0	0	
CLK2P	1197	broad.mit.edu	37	7	23624866	23624866	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:23624866G>A	uc003swk.2	-	1	1281	c.631C>T	c.(631-633)CGG>TGG	p.R211W		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						AGATACTGCCGCAGCGGTTTG	0.507000													34	55					0	0	1	0	0	
GHRHR	2692	broad.mit.edu	37	7	31013640	31013640	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:31013640C>T	uc003tbx.2	+	7	686	c.638C>T	c.(637-639)ACC>ATC	p.T213I	GHRHR_uc003tbw.1_Missense_Mutation_p.T213I|GHRHR_uc003tby.2_Missense_Mutation_p.T149I|GHRHR_uc003tbz.2_Intron	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	213	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CATTTCGCCACCATGACCAAC	0.622000													54	66					0	0	1	0	0	
GLI3	2737	broad.mit.edu	37	7	42005852	42005852	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:42005852G>A	uc011kbh.1	-	15	2910	c.2819C>T	c.(2818-2820)CCG>CTG	p.P940L	GLI3_uc011kbg.1_Missense_Mutation_p.P881L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	940					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P940T(1)		lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CGTCGGCGGCGGCCCTCCTGT	0.711000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				13	23					0	0	1	0	0	
HECW1	23072	broad.mit.edu	37	7	43503275	43503275	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:43503275C>T	uc003tid.1	+	14	3273	c.2668C>T	c.(2668-2670)CGA>TGA	p.R890*	HECW1_uc011kbi.1_Nonsense_Mutation_p.R856*	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	890	Potential.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AAACATTCAGCGAACCATTGC	0.488000													24	53					0	0	1	0	0	
URGCP	55665	broad.mit.edu	37	7	43916923	43916923	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:43916923A>G	uc003tiw.2	-	6	2196	c.2139T>C	c.(2137-2139)TTT>TTC	p.F713F	URGCP_uc003tiu.2_Silent_p.F670F|URGCP_uc003tiv.2_Silent_p.F638F|URGCP_uc003tix.2_Silent_p.F704F|URGCP_uc003tiy.2_Silent_p.F670F|URGCP_uc003tiz.2_Silent_p.F670F|URGCP_uc011kbj.1_Silent_p.F670F	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	713					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						ACCGCAGCCCAAACATGGTGT	0.627000													22	39					0	0	1	0	0	
PGAM2	5224	broad.mit.edu	37	7	44105054	44105054	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:44105054C>T	uc003tjs.2	-	1	110	c.75G>A	c.(73-75)TGG>TGA	p.W25*		NM_000290	NP_000281	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2	25					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity				0						CTGCATCGAACCAGCCACAGA	0.597000													33	42					0	0	1	0	0	
GCK	2645	broad.mit.edu	37	7	44186118	44186118	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:44186118G>A	uc003tkl.2	-	8	1433	c.963C>T	c.(961-963)TCC>TCT	p.S321S	GCK_uc003tkh.1_5'Flank|GCK_uc003tki.1_5'Flank|GCK_uc003tkj.1_Silent_p.S320S|GCK_uc003tkk.1_Silent_p.S322S	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	321					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GCAGCTGCTCGGAGGCCTCCC	0.647000													30	30					0	0	1	0	0	
GCK	2645	broad.mit.edu	37	7	44193002	44193002	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:44193002G>A	uc003tkl.2	-	2	576	c.106C>T	c.(106-108)CGG>TGG	p.R36W	GCK_uc003tkj.1_Missense_Mutation_p.R35W|GCK_uc003tkk.1_Missense_Mutation_p.R37W	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	36			R -> W (in MODY2).		cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						TTCTGCATCCGTCTCATCACC	0.627000													77	128					0	0	1	0	0	
NPC1L1	29881	broad.mit.edu	37	7	44578499	44578499	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:44578499C>T	uc003tlb.2	-	2	1553	c.1497G>A	c.(1495-1497)ACG>ACA	p.T499T	NPC1L1_uc003tlc.2_Silent_p.T499T|NPC1L1_uc011kbw.1_Silent_p.T499T|NPC1L1_uc003tld.2_Silent_p.T499T	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	499	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCAGCAGGAGCGTGCGGTTGT	0.567000													33	47					0	0	1	0	0	
IGFBP1	3484	broad.mit.edu	37	7	45928424	45928424	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:45928424G>T	uc003tnp.2	+	1	466	c.173G>T	c.(172-174)GGC>GTC	p.G58V	IGFBP1_uc003tno.3_Missense_Mutation_p.G58V|IGFBP1_uc010kyn.2_Missense_Mutation_p.G58V	NM_000596	NP_000587	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	58	IGFBP N-terminal.					extracellular space	insulin-like growth factor binding			lung(1)	1						GCCGGCTGCGGCTGTTGCCCG	0.776000													3	4					0.004672	0.00471796	1	1	0	
EGFR	1956	broad.mit.edu	37	7	55238900	55238900	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:55238900C>T	uc003tqk.2	+	16	2159	c.1913C>T	c.(1912-1914)ACG>ATG	p.T638M	EGFR_uc010kzg.1_Missense_Mutation_p.T593M|EGFR_uc011kco.1_Missense_Mutation_p.T585M|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	638	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGCTGTCCAACGAATGGGTAA	0.438000		8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			15	36					0	0	1	0	0	
ZNF716	441234	broad.mit.edu	37	7	57522222	57522222	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:57522222C>A	uc011kdi.1	+	2	208	c.96C>A	c.(94-96)TGC>TGA	p.C32*		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AATGGCAATGCCTGGATCATG	0.373000													17	30					2.48551e-13	2.61948e-13	1	1	0	
WBSCR17	64409	broad.mit.edu	37	7	70597962	70597962	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:70597962C>A	uc003tvy.2	+	1	174	c.174C>A	c.(172-174)CCC>CCA	p.P58P		NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	58	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GCGCCAGCCCCATCCAGGATG	0.711000													16	19					1.52009e-12	1.59956e-12	1	1	0	
TYW1B	441250	broad.mit.edu	37	7	72267523	72267523	+	Silent	SNP	G	A	A	rs138229913	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:72267523G>A	uc011kej.1	-	6	897	c.738C>T	c.(736-738)TTC>TTT	p.F246F	TYW1B_uc011keh.1_Silent_p.F84F|TYW1B_uc011kek.1_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	246					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						TGGAGCTCTCGAAGGGTTCTT	0.448000													4	50					0	0	1	0	0	
STX1A	6804	broad.mit.edu	37	7	73118587	73118587	+	Splice_Site	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:73118587C>T	uc003tyx.2	-	6	385	c.358_splice	c.e6-1	p.H120_splice	WBSCR22_uc003tyw.1_3'UTR|STX1A_uc003tyy.2_Splice_Site_p.H120_splice|STX1A_uc010lbj.1_Splice_Site_p.H120_splice	NM_004603	NP_004594	Q16623	STX1A_HUMAN	syntaxin 1A isoform 1						energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity				0		Lung NSC(55;0.0908)|all_lung(88;0.198)				GCGTGGAGTGCTGGGGGCCCG	0.657000													17	23					0	0	1	0	0	
CLDN3	1365	broad.mit.edu	37	7	73184217	73184217	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:73184217C>G	uc003tzg.3	-	1	384	c.163G>C	c.(163-165)GTG>CTG	p.V55L	RFC2_uc011kfa.1_Intron	NM_001306	NP_001297	O15551	CLD3_HUMAN	claudin 3	55	Extracellular (Potential).				response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity				0		Lung NSC(55;0.159)				GTGCTCTGCACCACGCAGTTC	0.642000													23	38					0	0	1	0	0	
LIMK1	3984	broad.mit.edu	37	7	73535598	73535598	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:73535598C>T	uc003uaa.1	+	16	2076	c.1911C>T	c.(1909-1911)AGC>AGT	p.S637S	RFC2_uc011kfa.1_Intron|LIMK1_uc010lbl.1_RNA|LIMK1_uc003uab.2_Silent_p.S603S	NM_002314	NP_002305	P53667	LIMK1_HUMAN	LIM domain kinase 1	637					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			stomach(2)|ovary(1)	3		Lung NSC(55;0.137)				GCGGCGAGAGCGGACTGCCTG	0.692000													6	16					0	0	1	0	0	
CLIP2	7461	broad.mit.edu	37	7	73753186	73753186	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:73753186C>T	uc003uam.2	+	3	857	c.530C>T	c.(529-531)ACG>ATG	p.T177M	CLIP2_uc003uan.2_Missense_Mutation_p.T177M	NM_003388	NP_003379	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	177						microtubule associated complex				skin(3)	3						GGCACGGCCACGCCCCCGCTG	0.672000													20	30					0	0	1	0	0	
POM121C	100101267	broad.mit.edu	37	7	75070845	75070845	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:75070845G>A	uc010lde.1	-	2	656	c.656C>T	c.(655-657)CCG>CTG	p.P219L	POM121C_uc003udk.3_5'UTR|POM121C_uc003udl.1_RNA			A8CG34	P121C_HUMAN	Homo sapiens POM121-2 mRNA for nuclear pore membrane protein 121-2, partial cds.	219	Required for targeting to the nucleus and nuclear pore complex.|Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						AAGTACCCCCGGACAGGAATA	0.527000													9	9					0	0	1	0	0	
RHBDD2	57414	broad.mit.edu	37	7	75511493	75511493	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:75511493G>A	uc003udw.1	+	2	609	c.525G>A	c.(523-525)TCG>TCA	p.S175S	RHBDD2_uc003udv.1_Silent_p.S34S	NM_001040456	NP_001035546	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2 isoform a	175	Helical; (Potential).					integral to membrane	serine-type endopeptidase activity				0						TGGGTGCCTCGTGGCTCATTC	0.597000													5	49					0	0	1	0	0	
GRM3	2913	broad.mit.edu	37	7	86469103	86469103	+	Missense_Mutation	SNP	C	T	T	rs141671463		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:86469103C>T	uc003uid.2	+	4	3372	c.2273C>T	c.(2272-2274)ACG>ATG	p.T758M	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.T630M|GRM3_uc010leh.2_Missense_Mutation_p.T350M	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	758	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane		p.T758M(1)		lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	GCCTTCAAAACGCGGAAGTGC	0.428000													28	46					0	0	1	0	0	
ABCB4	5244	broad.mit.edu	37	7	87092178	87092178	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:87092178G>A	uc003uiv.1	-	4	258	c.182C>T	c.(181-183)ACC>ATC	p.T61I	ABCB4_uc003uiw.1_Missense_Mutation_p.T61I|ABCB4_uc003uix.1_Missense_Mutation_p.T61I|ABCB4_uc003uiy.2_Missense_Mutation_p.T61I	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	61	ABC transmembrane type-1 1.|Helical; (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GGCCATGATGGTACCCAGCGA	0.398000													27	35					0	0	1	0	0	
ABCB1	5243	broad.mit.edu	37	7	87150160	87150160	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:87150160G>A	uc003uiz.1	-	23	3136	c.2718C>T	c.(2716-2718)ACC>ACT	p.T906T	ABCB1_uc011khc.1_Silent_p.T842T	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	906	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AAGAAACAACGGTTCGGAAGT	0.418000													25	42					0	0	1	0	0	
AKAP9	10142	broad.mit.edu	37	7	91708607	91708607	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:91708607A>G	uc003ulg.2	+	31	7385	c.7160A>G	c.(7159-7161)CAA>CGA	p.Q2387R	AKAP9_uc003ulf.2_Missense_Mutation_p.Q2379R|AKAP9_uc003uli.2_Missense_Mutation_p.Q2010R|AKAP9_uc003ulj.2_Missense_Mutation_p.Q157R	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2399	Potential.|Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTAAAACATCAATTGGATGTG	0.368000			T	BRAF	papillary thyroid								34	51					0	0	1	0	0	
AKAP9	10142	broad.mit.edu	37	7	91712892	91712892	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:91712892C>T	uc003ulg.2	+	33	8794	c.8569C>T	c.(8569-8571)CAC>TAC	p.H2857Y	AKAP9_uc003ulf.2_Missense_Mutation_p.H2849Y|AKAP9_uc003uli.2_Missense_Mutation_p.H2480Y|AKAP9_uc003ulj.2_Missense_Mutation_p.H627Y|AKAP9_uc003ulk.2_Missense_Mutation_p.H132Y	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	2869					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAGAGGGAACACTATGTTGC	0.368000			T	BRAF	papillary thyroid								21	29					0	0	1	0	0	
ANKIB1	54467	broad.mit.edu	37	7	91936795	91936795	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:91936795C>T	uc003ulw.2	+	3	687	c.311C>T	c.(310-312)GCA>GTA	p.A104V		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	104							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CCTCGCTTGGCACGCCCCACA	0.423000													34	62					0	0	1	0	0	
PEG10	23089	broad.mit.edu	37	7	94293052	94293052	+	Missense_Mutation	SNP	C	T	T	rs147863226	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:94293052C>T	uc011kie.1	+	2	629	c.412C>T	c.(412-414)CGC>TGC	p.R138C		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	62					apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CATCGAGCTCCGCGGTGCTGC	0.597000													4	14					0	0	1	0	0	
DLX5	1749	broad.mit.edu	37	7	96650268	96650268	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:96650268G>A	uc003uon.2	-	3	858	c.650C>T	c.(649-651)TCG>TTG	p.S217L		NM_005221	NP_005212	P56178	DLX5_HUMAN	distal-less homeobox 5	217					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					AGACTGCGGCGAGTTACACGC	0.617000													22	28					0	0	1	0	0	
LMTK2	22853	broad.mit.edu	37	7	97800879	97800879	+	Silent	SNP	C	T	T	rs138179178		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:97800879C>T	uc003upd.1	+	7	977	c.684C>T	c.(682-684)AGC>AGT	p.S228S		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	228	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					ATCTGCGCAGCGAGCAGGAGC	0.607000													27	52					0	0	1	0	0	
TECPR1	25851	broad.mit.edu	37	7	97850995	97850995	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:97850995C>T	uc003upg.2	-	23	3340	c.3135G>A	c.(3133-3135)TCG>TCA	p.S1045S		NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	1045	TECPR 8.					integral to membrane	protein binding			pancreas(1)	1						GGGCATACACCGACGTCTGCC	0.423000													17	31					0	0	1	0	0	
TRRAP	8295	broad.mit.edu	37	7	98490105	98490105	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:98490105G>A	uc003upp.2	+	5	529	c.320G>A	c.(319-321)CGT>CAT	p.R107H	TRRAP_uc011kis.1_Missense_Mutation_p.R107H	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	107					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GAACATCTTCGTCCTCACACA	0.333000													35	57					0	0	1	0	0	
SMURF1	57154	broad.mit.edu	37	7	98636091	98636091	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:98636091G>A	uc003upu.1	-	15	2006	c.1686C>T	c.(1684-1686)TTC>TTT	p.F562F	SMURF1_uc003upv.1_Silent_p.F536F|SMURF1_uc003upt.2_Silent_p.F536F	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	562	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GGATCCGCCCGAAGGCGTTGT	0.507000													20	36					0	0	1	0	0	
SMURF1	57154	broad.mit.edu	37	7	98655069	98655069	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:98655069A>C	uc003upu.1	-	4	629	c.309T>G	c.(307-309)AAT>AAG	p.N103K	SMURF1_uc003upv.1_Missense_Mutation_p.N103K|SMURF1_uc003upt.2_Missense_Mutation_p.N103K	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	103					BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			TGCTGATGGCATTGGAGAGCA	0.443000													33	38					0	0	1	0	0	
COPS6	10980	broad.mit.edu	37	7	99688088	99688088	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:99688088C>T	uc003usu.2	+	4	432	c.401C>T	c.(400-402)TCG>TTG	p.S134L		NM_006833	NP_006824	Q7L5N1	CSN6_HUMAN	COP9 signalosome subunit 6	134	MPN.				cullin deneddylation|interspecies interaction between organisms	cytoplasm|signalosome	protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CCTGACCCCTCGGACATCCAC	0.532000													20	36					0	0	1	0	0	
EPHB4	2050	broad.mit.edu	37	7	100405135	100405135	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:100405135C>T	uc003uwn.1	-	13	2677	c.2186G>A	c.(2185-2187)CGG>CAG	p.R729Q	EPHB4_uc003uwm.1_Missense_Mutation_p.R636Q|EPHB4_uc010lhj.1_Missense_Mutation_p.R729Q	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	729	Cytoplasmic (Potential).|Protein kinase.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GGCAAGGTACCGCATGCCCGA	0.592000													40	45					0	0	1	0	0	
EMID2	136227	broad.mit.edu	37	7	101196619	101196619	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:101196619G>A	uc010lhy.1	+	11	1228	c.1036G>A	c.(1036-1038)GTG>ATG	p.V346M	EMID2_uc003uyo.1_Missense_Mutation_p.V348M	NM_133457	NP_597714	Q96A83	EMID2_HUMAN	EMI domain containing 2	348	Collagen-like 2.					collagen				ovary(1)	1	Lung NSC(181;0.215)					TGAACCTGGCGTGAAGGGGGA	0.617000													29	35					0	0	1	0	0	
ORAI2	80228	broad.mit.edu	37	7	102087230	102087230	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:102087230G>C	uc010lhz.1	+	4	731	c.496G>C	c.(496-498)GTG>CTG	p.V166L	ORAI2_uc003uzj.2_Missense_Mutation_p.V166L|ORAI2_uc003uzk.2_Missense_Mutation_p.V166L|ORAI2_uc011kks.1_Missense_Mutation_p.V89L	NM_001126340	NP_001119812	Q96SN7	ORAI2_HUMAN	ORAI calcium release-activated calcium modulator	166	Helical; (Potential).					integral to membrane	protein binding			ovary(1)|kidney(1)	2						GGCCGAGGTGGTGCTGCTCTG	0.682000													46	89					0	0	1	0	0	
LRRC17	10234	broad.mit.edu	37	7	102575025	102575025	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:102575025C>T	uc003vau.2	+	2	1054	c.665C>T	c.(664-666)CCG>CTG	p.P222L	FBXL13_uc010liq.1_Intron|FBXL13_uc003vaq.2_Intron|FBXL13_uc010lir.1_Intron|FBXL13_uc003var.2_Intron|FBXL13_uc003vas.2_Intron|LRRC17_uc003vat.2_Missense_Mutation_p.P222L	NM_001031692	NP_001026862	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17 isoform 1	222					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				ovary(1)	1						CAATTGGACCCGAAACCCCAA	0.423000													19	34					0	0	1	0	0	
PSMC2	5701	broad.mit.edu	37	7	103004703	103004703	+	Silent	SNP	G	A	A	rs144680798		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:103004703G>A	uc003vbs.2	+	8	775	c.705G>A	c.(703-705)GCG>GCA	p.A235A	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Silent_p.A98A	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	235					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						GGACTGATGCGTGCTTCATTC	0.468000													51	104					0	0	1	0	0	
RELN	5649	broad.mit.edu	37	7	103185661	103185661	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:103185661C>T	uc003vca.2	-	42	6593	c.6433G>A	c.(6433-6435)GGA>AGA	p.G2145R	RELN_uc010liz.2_Missense_Mutation_p.G2145R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2145	EGF-like 5.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CATTTGGTTCCATTGATACAG	0.453000													45	63					0	0	1	0	0	
RELN	5649	broad.mit.edu	37	7	103197465	103197465	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:103197465G>A	uc003vca.2	-	38	5916	c.5756C>T	c.(5755-5757)ACC>ATC	p.T1919I	RELN_uc010liz.2_Missense_Mutation_p.T1919I	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1919					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTAGCATTGGTTTGGGCAGT	0.393000													88	118					0	0	1	0	0	
PUS7	54517	broad.mit.edu	37	7	105121515	105121515	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:105121515T>C	uc003vcx.2	-	9	1378	c.1159A>G	c.(1159-1161)ACG>GCG	p.T387A	PUS7_uc010lji.2_Missense_Mutation_p.T393A|PUS7_uc003vcy.2_Missense_Mutation_p.T387A|PUS7_uc003vcz.1_Missense_Mutation_p.T387A	NM_019042	NP_061915	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog	387	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)	1						ACCTGATACGTAGGGACAGCT	0.363000													20	24					0	0	1	0	0	
ATXN7L1	222255	broad.mit.edu	37	7	105516905	105516905	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:105516905G>T	uc003vde.2	-	1	127	c.100C>A	c.(100-102)CGC>AGC	p.R34S	ATXN7L1_uc003vdi.2_Missense_Mutation_p.R34S|CDHR3_uc003vdk.2_5'Flank|uc003vdj.1_5'Flank	NM_020725	NP_065776	Q9ULK2	AT7L1_HUMAN	ataxin 7-like 1 isoform 1	34											0						GGCACTTTGCGATCCAGTGTC	0.577000													17	21					9.16793e-09	9.48677e-09	1	1	0	
PIK3CG	5294	broad.mit.edu	37	7	106508275	106508275	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:106508275G>A	uc003vdv.3	+	2	354	c.269G>A	c.(268-270)CGG>CAG	p.R90Q	PIK3CG_uc003vdu.2_Missense_Mutation_p.R90Q|PIK3CG_uc003vdw.2_Missense_Mutation_p.R90Q	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	90					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding	p.R90W(1)		lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TTCTACCACCGGCTGGGACCG	0.642000													14	19					0	0	1	0	0	
LAMB1	3912	broad.mit.edu	37	7	107591745	107591745	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:107591745A>G	uc003vew.2	-	24	3652	c.3317T>C	c.(3316-3318)ATG>ACG	p.M1106T	LAMB1_uc003vev.2_Missense_Mutation_p.M1130T	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1106	Laminin EGF-like 12.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAACCCAGGCATGCACTGGCA	0.592000													9	38					0	0	1	0	0	
NRCAM	4897	broad.mit.edu	37	7	107872810	107872810	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:107872810G>A	uc003vfb.2	-	7	858	c.387C>T	c.(385-387)CGC>CGT	p.R129R	NRCAM_uc003vfc.2_Silent_p.R123R|NRCAM_uc011kmk.1_Silent_p.R124R|NRCAM_uc003vfd.2_Silent_p.R124R|NRCAM_uc003vfe.2_Silent_p.R124R	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	129	Ig-like 1.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						CTGCAGCTCCGCGTTCGTTCC	0.458000													9	122					0	0	1	0	0	
IQUB	154865	broad.mit.edu	37	7	123142741	123142741	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:123142741A>G	uc003vkn.2	-	6	1510	c.933T>C	c.(931-933)ATT>ATC	p.I311I	IQUB_uc003vko.2_Silent_p.I311I|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Silent_p.I311I|IQUB_uc003vkq.2_3'UTR	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	311										ovary(3)|large_intestine(1)	4						CATATACACCAATGTTAGTCA	0.323000													3	31					0	0	1	0	0	
SND1	27044	broad.mit.edu	37	7	127338982	127338982	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:127338982C>A	uc003vmi.2	+	4	629	c.403C>A	c.(403-405)CGG>AGG	p.R135R		NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	135	TNase-like 1.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CTTAGCCACCCGGAGAGAAGG	0.463000													14	20					0.00316338	0.00319607	1	1	0	
LRRC4	64101	broad.mit.edu	37	7	127669747	127669747	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:127669747C>T	uc003vmk.2	-	2	1084	c.947G>A	c.(946-948)CGA>CAA	p.R316Q	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	316	Extracellular (Potential).|LRRCT.					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		TATATACTCTCGAAGCCACCA	0.567000													10	22					0	0	1	0	0	
LRRC4	64101	broad.mit.edu	37	7	127669830	127669830	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:127669830C>T	uc003vmk.2	-	2	1001	c.864G>A	c.(862-864)CCG>CCA	p.P288P	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	288	LRR 9.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GGTACCTCAGCGGGGTAAAGA	0.517000													12	33					0	0	1	0	0	
FAM71F1	84691	broad.mit.edu	37	7	128359088	128359088	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:128359088C>T	uc003vno.1	+	3	691	c.638C>T	c.(637-639)ACG>ATG	p.T213M	FAM71F1_uc010llo.1_Missense_Mutation_p.T114M|FAM71F1_uc011koq.1_Missense_Mutation_p.T105M|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Missense_Mutation_p.T114M|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.T213M	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	213										skin(1)	1						ATTCTTGTCACGCACTGCCTG	0.537000													37	73					0	0	1	0	0	
FLNC	2318	broad.mit.edu	37	7	128486812	128486812	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:128486812G>A	uc003vnz.3	+	24	4350	c.4141G>A	c.(4141-4143)GGG>AGG	p.G1381R	FLNC_uc003voa.3_Missense_Mutation_p.G1381R	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1381	Filamin 12.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						AGCGGGCACCGGGGGCCTTGG	0.587000													17	40					0	0	1	0	0	
STRA8	346673	broad.mit.edu	37	7	134928082	134928082	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:134928082C>A	uc011kpx.1	+	4	339	c.339C>A	c.(337-339)TCC>TCA	p.S113S		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	STRA8	113					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus					0						CAATAGCATCCTTCAACCTGG	0.512000													24	48					1.17739e-12	1.23958e-12	1	1	0	
DGKI	9162	broad.mit.edu	37	7	137294333	137294333	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:137294333C>T	uc003vtt.2	-	9	1017	c.1016G>A	c.(1015-1017)CGG>CAG	p.R339Q	DGKI_uc003vtu.2_Missense_Mutation_p.R39Q	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	339					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTTCTTCTTCCGATTTGAAGC	0.423000													22	28					0	0	1	0	0	
BRAF	673	broad.mit.edu	37	7	140534454	140534454	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:140534454T>C	uc003vwc.3	-	3	520	c.459A>G	c.(457-459)CAA>CAG	p.Q153Q		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	153					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	CGATAGGTTTTTGTGGTGACT	0.413000		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				61	89					0	0	1	0	0	
SSBP1	6742	broad.mit.edu	37	7	141438980	141438980	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:141438980C>A	uc003vwo.1	+	2	92	c.14C>A	c.(13-15)CCT>CAT	p.P5H	FLJ40852_uc011krh.1_5'Flank|FLJ40852_uc010lnm.2_5'Flank|FLJ40852_uc010lnn.2_5'Flank|FLJ40852_uc003vwm.3_5'Flank|FLJ40852_uc010lno.2_5'Flank|SSBP1_uc011kri.1_Missense_Mutation_p.P5H|SSBP1_uc010lnp.1_Missense_Mutation_p.P5H	NM_003143	NP_003134	Q04837	SSBP_HUMAN	single-stranded DNA binding protein 1 precursor	5					DNA replication|positive regulation of helicase activity	mitochondrial nucleoid	single-stranded DNA binding			ovary(1)	1	Melanoma(164;0.0171)					TTTCGAAGACCTGTATTACAG	0.338000													47	73					2.5401e-28	2.74609e-28	1	1	0	
Unknown	0	broad.mit.edu	37	7	142001204	142001204	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:142001204G>A	uc011kro.1	+	2	341	c.296G>A	c.(295-297)CGG>CAG	p.R99Q						SubName: Full=V_segment translation product; Flags: Fragment;																		CTGAAGATCCGGTCCACAAAG	0.443000													9	11					0	0	1	0	0	
TAS2R40	259286	broad.mit.edu	37	7	142919509	142919509	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:142919509C>T	uc011ksx.1	+	1	338	c.338C>T	c.(337-339)GCC>GTC	p.A113V		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	113	Helical; Name=3; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					TGGTTTGCTGCCTGGCTCAAA	0.393000													46	90					0	0	1	0	0	
FAM115C	285966	broad.mit.edu	37	7	143400364	143400364	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:143400364G>A	uc003wdf.2	+	2	360	c.277G>A	c.(277-279)GTG>ATG	p.V93M	FAM115C_uc003wdg.2_Intron|FAM115C_uc011ktk.1_Intron|FAM115C_uc003wdh.2_Missense_Mutation_p.V93M|FAM115C_uc011ktm.1_Intron|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	93											0						TGGGGCTCCCGTGGGAGTGCA	0.582000													18	64					0	0	1	0	0	
CNTNAP2	26047	broad.mit.edu	37	7	147183036	147183036	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:147183036C>T	uc003weu.1	+	11	2196	c.1680C>T	c.(1678-1680)CCC>CCT	p.P560P		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	560	EGF-like 1.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GATGTGTGCCCAATCACTGTG	0.453000										HNSCC(39;0.1)			46	91					0	0	1	0	0	
KRBA1	84626	broad.mit.edu	37	7	149430494	149430494	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:149430494C>T	uc003wfz.2	+	18	2850	c.2451C>T	c.(2449-2451)CTC>CTT	p.L817L	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.L424L	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	817	Potential.									ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGATCGGCTCGCCACAGCGC	0.692000													11	12					0	0	1	0	0	
SSPO	23145	broad.mit.edu	37	7	149485991	149485991	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:149485991G>A	uc010lpk.2	+	29	4210	c.4210G>A	c.(4210-4212)GAT>AAT	p.D1404N		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	1404	LDL-receptor class A 1.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGACTGTGGCGATGGCTCTGA	0.587000													15	15					0	0	1	0	0	
ABP1	26	broad.mit.edu	37	7	150554844	150554844	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:150554844G>A	uc003why.1	+	3	5504	c.1286G>A	c.(1285-1287)CGG>CAG	p.R429Q	ABP1_uc003whz.1_Missense_Mutation_p.R429Q|ABP1_uc003wia.1_Missense_Mutation_p.R429Q	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	429					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	CCCCTTCGGCGGCACTTTAAT	0.527000													36	28					0	0	1	0	0	
SLC4A2	6522	broad.mit.edu	37	7	150771378	150771378	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:150771378C>T	uc003wit.3	+	17	3044	c.2788C>T	c.(2788-2790)CGG>TGG	p.R930W	SLC4A2_uc011kve.1_Missense_Mutation_p.R921W|SLC4A2_uc003wiu.3_Missense_Mutation_p.R916W|SLC4A2_uc003wiv.3_Missense_Mutation_p.R124W	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	930	Membrane (anion exchange).|Cytoplasmic (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTTCCTGGCCGGGTGCGTGG	0.637000													32	46					0	0	1	0	0	
MLL3	58508	broad.mit.edu	37	7	151877839	151877839	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:151877839T>C	uc003wla.2	-	36	7325	c.7106A>G	c.(7105-7107)AAT>AGT	p.N2369S	MLL3_uc003wkz.2_Missense_Mutation_p.N1430S|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2369					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATTTACAGTATTCTGTGTATC	0.418000			N		medulloblastoma								30	44					0	0	1	0	0	
DPP6	1804	broad.mit.edu	37	7	154561207	154561207	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:154561207C>T	uc003wlk.2	+	9	1093	c.964C>T	c.(964-966)CGT>TGT	p.R322C	DPP6_uc003wli.2_Missense_Mutation_p.R258C|DPP6_uc003wlm.2_Missense_Mutation_p.R260C|DPP6_uc011kvq.1_Missense_Mutation_p.R215C	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	322	Extracellular (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CAATGATTCCCGTGTCCCCAT	0.552000													21	26					0	0	1	0	0	
HTR5A	3361	broad.mit.edu	37	7	154862986	154862986	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:154862986C>T	uc003wlu.1	+	1	441	c.377C>T	c.(376-378)ACG>ATG	p.T126M	uc011kvt.1_Missense_Mutation_p.V10M|uc003wlt.2_Missense_Mutation_p.V10M	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	126	Helical; Name=3; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CTTTGCTGCACGGCCAGCATC	0.652000													15	27					0	0	1	0	0	
INSIG1	3638	broad.mit.edu	37	7	155094088	155094088	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:155094088C>T	uc003wly.2	+	4	876	c.665C>T	c.(664-666)ACG>ATG	p.T222M	INSIG1_uc011kvu.1_Missense_Mutation_p.T70M|INSIG1_uc003wlz.2_Intron	NM_005542	NP_005533	O15503	INSI1_HUMAN	insulin induced gene 1 isoform 1	222	Helical; (Potential).				cell proliferation|ER-nuclear sterol response pathway	endoplasmic reticulum membrane|integral to membrane	protein binding				0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTTCTAGCTACGCTGATCACG	0.433000													22	28					0	0	1	0	0	
CNPY1	285888	broad.mit.edu	37	7	155301697	155301697	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:155301697C>T	uc003wmc.1	-	2	181	c.36G>A	c.(34-36)ACG>ACA	p.T12T		NM_001103176	NP_001096646	Q3B7I2	CNPY1_HUMAN	canopy 1 homolog	12											0	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TTCTCTCCTTCGTCACAGGGT	0.418000													33	58					0	0	1	0	0	
RBM33	155435	broad.mit.edu	37	7	155534589	155534589	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:155534589G>A	uc010lqk.1	+	13	2494	c.2126G>A	c.(2125-2127)CGT>CAT	p.R709H	RBM33_uc011kvv.1_Missense_Mutation_p.R518H	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	709							nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		AGCAATTTGCGTGAATTACCC	0.507000													54	99					0	0	1	0	0	
DNAJB6	10049	broad.mit.edu	37	7	157177650	157177650	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:157177650T>A	uc003wnk.2	+	7	722	c.568T>A	c.(568-570)TCG>ACG	p.S190T	DNAJB6_uc003wnj.2_Missense_Mutation_p.S190T|DNAJB6_uc003wnl.2_Missense_Mutation_p.S177T|DNAJB6_uc011kvy.1_Missense_Mutation_p.S141T|DNAJB6_uc011kvz.1_Intron|DNAJB6_uc010lqt.2_Missense_Mutation_p.S190T	NM_058246	NP_490647	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	190	Interaction with KRT18.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding	p.S190S(1)		ovary(2)	2	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CAACTTCAAATCGATATCAAC	0.403000													8	93					0	0	1	0	0	
PTPRN2	5799	broad.mit.edu	37	7	158109576	158109576	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:158109576C>T	uc003wno.2	-	3	333	c.212G>A	c.(211-213)CGC>CAC	p.R71H	PTPRN2_uc003wnp.2_Missense_Mutation_p.R54H|PTPRN2_uc003wnq.2_Missense_Mutation_p.R71H|PTPRN2_uc003wnr.2_Intron|PTPRN2_uc011kwa.1_Missense_Mutation_p.R94H	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	71	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CACCTCGTAGCGGTAAAAGTC	0.607000													13	28					0	0	1	0	0	
ESYT2	57488	broad.mit.edu	37	7	158526907	158526907	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:158526907C>T	uc003wob.1	-	22	2739	c.2673G>A	c.(2671-2673)GCG>GCA	p.A891A	ESYT2_uc003wny.1_RNA|ESYT2_uc003wnz.1_Silent_p.A330A|ESYT2_uc003woa.1_Silent_p.A468A	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	919						integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						GCTATGTCATCGCCTGAGGCC	0.527000													17	24					0	0	1	0	0	
ARHGEF10	9639	broad.mit.edu	37	8	1876637	1876637	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:1876637G>A	uc003wpr.2	+	24	2920	c.2742G>A	c.(2740-2742)TCG>TCA	p.S914S	ARHGEF10_uc003wps.2_Silent_p.S876S|ARHGEF10_uc010lre.2_Silent_p.S565S	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	939					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CCATCGTCTCGTTTCAAAATT	0.488000													62	162					0	0	1	0	0	
ARHGEF10	9639	broad.mit.edu	37	8	1900959	1900959	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:1900959G>A	uc003wpr.2	+	28	3664	c.3486G>A	c.(3484-3486)CCG>CCA	p.P1162P	ARHGEF10_uc003wps.2_Silent_p.P1124P|ARHGEF10_uc010lre.2_Silent_p.P813P	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	1187					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TGGCCCTGCCGGTCCCACGTC	0.642000													25	81					0	0	1	0	0	
MYOM2	9172	broad.mit.edu	37	8	2017398	2017398	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:2017398G>A	uc003wpx.3	+	7	793	c.655G>A	c.(655-657)GCA>ACA	p.A219T	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	219	Ig-like C2-type 1.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CTCTCCAAGGGCAGACTTTGA	0.522000													18	23					0	0	1	0	0	
CSMD1	64478	broad.mit.edu	37	8	3081363	3081363	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:3081363G>T	uc011kwk.1	-	28	4765	c.4375C>A	c.(4375-4377)CCA>ACA	p.P1459T	CSMD1_uc011kwj.1_Missense_Mutation_p.P851T|CSMD1_uc003wqe.2_Missense_Mutation_p.P615T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1459	Extracellular (Potential).|CUB 9.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACACCTGCTGGGCCCGTCAGA	0.507000													19	45					0.00741294	0.00747851	1	1	0	
CSMD1	64478	broad.mit.edu	37	8	3141845	3141845	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:3141845G>A	uc011kwk.1	-	26	4367	c.3977C>T	c.(3976-3978)ACG>ATG	p.T1326M	CSMD1_uc011kwj.1_Missense_Mutation_p.T718M|CSMD1_uc003wqe.2_Missense_Mutation_p.T482M	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1326	Extracellular (Potential).|CUB 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGCCATCTCCGTGTCGAAAAC	0.562000											OREG0018505	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	37					0	0	1	0	0	
CSMD1	64478	broad.mit.edu	37	8	3224649	3224649	+	Missense_Mutation	SNP	G	A	A	rs147113316	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:3224649G>A	uc011kwk.1	-	20	3413	c.3023C>T	c.(3022-3024)ACG>ATG	p.T1008M	CSMD1_uc011kwj.1_Missense_Mutation_p.T400M|CSMD1_uc003wqe.2_Missense_Mutation_p.T164M	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1008	Extracellular (Potential).|CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGCCTTGATCGTATGAGGCAA	0.478000													15	25					0	0	1	0	0	
CSMD1	64478	broad.mit.edu	37	8	3855509	3855509	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:3855509G>A	uc011kwk.1	-	5	1124	c.734C>T	c.(733-735)ACC>ATC	p.T245I		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	245	Extracellular (Potential).|CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGCGCAATGGTGTCCCCGGG	0.547000													4	11					0	0	1	0	0	
SGK223	157285	broad.mit.edu	37	8	8235431	8235431	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:8235431C>T	uc003wsh.3	-	2	488	c.488G>A	c.(487-489)GGC>GAC	p.G163D		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	163							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GTTGTGCAGGCCGACCATGGT	0.592000													32	111					0	0	1	0	0	
TNKS	8658	broad.mit.edu	37	8	9627729	9627729	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:9627729A>G	uc003wss.2	+	26	3859	c.3854A>G	c.(3853-3855)AAT>AGT	p.N1285S	TNKS_uc011kww.1_Missense_Mutation_p.N1048S	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1285	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		CCGAGCGTCAATGGGCTGGCA	0.473000													15	51					0	0	1	0	0	
TNKS	8658	broad.mit.edu	37	8	9627753	9627753	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:9627753T>C	uc003wss.2	+	26	3883	c.3878T>C	c.(3877-3879)GTC>GCC	p.V1293A	TNKS_uc011kww.1_Missense_Mutation_p.V1056A	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1293	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		GCTGAATATGTCATCTACAGA	0.468000													10	41					0	0	1	0	0	
SOX7	83595	broad.mit.edu	37	8	10583281	10583281	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:10583281C>T	uc003wtf.2	-	2	1213	c.1134G>A	c.(1132-1134)ACG>ACA	p.T378T	SOX7_uc011kwz.1_Silent_p.T430T	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	378	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		AGTACGTGGCCGTGGCATCAG	0.637000													13	57					0	0	1	0	0	
SOX7	83595	broad.mit.edu	37	8	10690428	10690428	+	Nonsense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:10690428C>A	uc011kwz.1	-	3	229	c.196G>T	c.(196-198)GGA>TGA	p.G66*	PINX1_uc003wth.2_Nonsense_Mutation_p.G66*|PINX1_uc003wti.2_Nonsense_Mutation_p.G66*	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	Error:Variant_position_missing_in_Q9BT81_after_alignment					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GCTCCGAGTCCCAGGTGGTTA	0.438000													7	17					1.76689e-08	1.8265e-08	1	1	0	
FAM86B1	85002	broad.mit.edu	37	8	12042911	12042911	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:12042911G>A	uc010lse.2	-	6	809	c.764C>T	c.(763-765)ACG>ATG	p.T255M	FAM66D_uc011kxp.1_Intron|FAM86B1_uc003wvf.3_RNA|FAM86B1_uc003wvi.3_Missense_Mutation_p.T61M|FAM86B1_uc010lsd.2_RNA|FAM86B1_uc003wvh.3_Missense_Mutation_p.T98M|FAM86B1_uc011kxq.1_Missense_Mutation_p.T61M|FAM86B1_uc010lsf.2_Missense_Mutation_p.T98M|FAM86B1_uc003wvj.3_Missense_Mutation_p.T189M|FAM86B1_uc003wvk.3_Missense_Mutation_p.T289M|FAM86B1_uc010lsg.2_RNA|FAM86B1_uc003wvl.3_RNA	NM_001083537	NP_001077006	Q8N7N1	F86B1_HUMAN	hypothetical protein LOC85002	255											0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		CAGCTGGCACGTCTCTGGGTT	0.647000													38	85					0	0	1	0	0	
LONRF1	91694	broad.mit.edu	37	8	12594270	12594270	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:12594270T>A	uc003wwd.1	-	6	1454	c.1391A>T	c.(1390-1392)TAT>TTT	p.Y464F	LONRF1_uc011kxv.1_Missense_Mutation_p.Y53F|LONRF1_uc010lsp.1_Missense_Mutation_p.Y64F	NM_152271	NP_689484	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger	464					proteolysis		ATP-dependent peptidase activity|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(644;0.236)		AATATCACCATAAGCTAAGGA	0.318000													34	102					0	0	1	0	0	
DLC1	10395	broad.mit.edu	37	8	13357421	13357421	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:13357421G>A	uc003wwm.2	-	2	604	c.160C>T	c.(160-162)CGC>TGC	p.R54C	DLC1_uc003wwn.2_Missense_Mutation_p.R54C|DLC1_uc011kxy.1_Missense_Mutation_p.R54C	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	54					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TTCTCTTTGCGGTCCACATTT	0.453000													70	232					0	0	1	0	0	
MTMR7	9108	broad.mit.edu	37	8	17198880	17198880	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:17198880G>A	uc003wxm.2	-	6	963	c.724C>T	c.(724-726)CGG>TGG	p.R242W	MTMR7_uc003wxn.2_Missense_Mutation_p.R21W	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	242	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		ACTTTAGGCCGGGTGTCAACG	0.542000													12	51					0	0	1	0	0	
PCM1	5108	broad.mit.edu	37	8	17810569	17810569	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:17810569C>T	uc003wyi.3	+	9	1584	c.1162C>T	c.(1162-1164)CGT>TGT	p.R388C	PCM1_uc011kyh.1_Missense_Mutation_p.R388C|PCM1_uc003wyj.3_Missense_Mutation_p.R388C|PCM1_uc003wyg.2_Missense_Mutation_p.R388C|PCM1_uc003wyh.2_Missense_Mutation_p.R427C|PCM1_uc010lta.1_Missense_Mutation_p.R427C	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	388					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		AGCTTCAGAACGTTTACCTGA	0.398000			T	RET|JAK2	papillary thyroid|CML|MPD								5	18					0	0	1	0	0	
SLC18A1	6570	broad.mit.edu	37	8	20036930	20036930	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:20036930C>T	uc011kyq.1	-	4	661	c.190G>A	c.(190-192)GGC>AGC	p.G64S	SLC18A1_uc003wzm.2_Missense_Mutation_p.G64S|SLC18A1_uc011kyr.1_Missense_Mutation_p.G64S|SLC18A1_uc003wzn.2_Missense_Mutation_p.G64S|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Missense_Mutation_p.G64S	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	64	Lumenal, vesicle (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		CCGGCATGGCCGAGGTGCAGA	0.517000													20	70					0	0	1	0	0	
HR	55806	broad.mit.edu	37	8	21977305	21977305	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:21977305C>T	uc003xas.2	-	14	3610	c.2945G>A	c.(2944-2946)CGT>CAT	p.R982H	HR_uc003xat.2_Missense_Mutation_p.R982H	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	982	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CTCCAGTGGACGCAGGGCAAG	0.627000													18	44					0	0	1	0	0	
LGI3	203190	broad.mit.edu	37	8	22006340	22006340	+	Missense_Mutation	SNP	C	T	T	rs143158388	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:22006340C>T	uc003xav.2	-	8	1269	c.980G>A	c.(979-981)CGC>CAC	p.R327H	LGI3_uc010ltu.2_Missense_Mutation_p.R303H	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	327	EAR 3.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		GTTAGGCTTGCGCACGCGCTG	0.617000													16	33					0	0	1	0	0	
PHYHIP	9796	broad.mit.edu	37	8	22079224	22079224	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:22079224C>T	uc003xbk.3	-	6	1329	c.635G>A	c.(634-636)CGC>CAC	p.R212H	PHYHIP_uc003xbj.3_Missense_Mutation_p.R212H	NM_001099335	NP_001092805	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	212											0				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		ATTGAAGAGGCGCTGAGCTGG	0.627000													4	29					0	0	1	0	0	
PIWIL2	55124	broad.mit.edu	37	8	22175773	22175773	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:22175773A>T	uc003xbn.2	+	20	2536	c.2388A>T	c.(2386-2388)TTA>TTT	p.L796F	PIWIL2_uc011kzf.1_Missense_Mutation_p.L796F|PIWIL2_uc010ltv.2_Missense_Mutation_p.L796F	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	796	Piwi.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		TGGGCTCCTTAAAAAAGTTTT	0.378000													5	90					0	0	1	0	0	
SORBS3	10174	broad.mit.edu	37	8	22424653	22424653	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:22424653G>A	uc003xbv.2	+	16	1610	c.1270G>A	c.(1270-1272)GGC>AGC	p.G424S	SORBS3_uc003xbw.3_Missense_Mutation_p.G82S	NM_005775	NP_005766	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3 isoform 1	424	SH3 1.|Binds to vinculin.				muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding				0		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		AGAGCACCACGGCCGCCTGGG	0.602000													35	77					0	0	1	0	0	
SORBS3	10174	broad.mit.edu	37	8	22428603	22428603	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:22428603C>T	uc003xbv.2	+	18	1952	c.1612C>T	c.(1612-1614)CGC>TGC	p.R538C	SORBS3_uc003xbw.3_Missense_Mutation_p.R196C	NM_005775	NP_005766	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3 isoform 1	538					muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding				0		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		CGCTGCCGCCCGCTCAGCCCG	0.706000													23	54					0	0	1	0	0	
EGR3	1960	broad.mit.edu	37	8	22548121	22548121	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:22548121C>T	uc003xcm.1	-	2	1387	c.1029G>A	c.(1027-1029)GCG>GCA	p.A343A	EGR3_uc011kzn.1_Silent_p.A305A|EGR3_uc011kzo.1_Silent_p.A289A	NM_004430	NP_004421	Q06889	EGR3_HUMAN	early growth response 3	343	C2H2-type 3.				circadian rhythm|muscle organ development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Prostate(55;0.0421)|Breast(100;0.102)		Colorectal(74;0.0145)|BRCA - Breast invasive adenocarcinoma(99;0.053)|COAD - Colon adenocarcinoma(73;0.0608)		CGTCGCTGCGCGCAAACTTGC	0.652000													35	105					0	0	1	0	0	
RHOBTB2	23221	broad.mit.edu	37	8	22864803	22864803	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:22864803G>A	uc003xcq.2	+	5	1582	c.1045G>A	c.(1045-1047)GAG>AAG	p.E349K	RHOBTB2_uc003xcp.2_Missense_Mutation_p.E371K|RHOBTB2_uc011kzp.1_Missense_Mutation_p.E356K|uc003xcr.2_RNA	NM_015178	NP_055993	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2 isoform 3	349	BTB 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			ovary(1)|lung(1)	2		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		TGACGTGTGCGAGAGCGTGGA	0.567000													22	58					0	0	1	0	0	
CHMP7	91782	broad.mit.edu	37	8	23106740	23106740	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:23106740G>A	uc003xdc.2	+	3	965	c.317G>A	c.(316-318)CGG>CAG	p.R106Q	CHMP7_uc011kzs.1_Intron|CHMP7_uc003xdd.2_5'UTR	NM_152272	NP_689485	Q8WUX9	CHMP7_HUMAN	CHMP family, member 7	106					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity				0		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		GAGCTGCAGCGGGAGTCAGAC	0.532000													29	81					0	0	1	0	0	
LOXL2	4017	broad.mit.edu	37	8	23159567	23159567	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:23159567G>A	uc003xdh.1	-	12	2445	c.2106C>T	c.(2104-2106)GAC>GAT	p.D702D	LOXL2_uc010lty.1_Silent_p.D241D	NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	702	Lysyl-oxidase like.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		CAGGGGGCACGTCAGTGATGT	0.612000													27	57					0	0	1	0	0	
LOXL2	4017	broad.mit.edu	37	8	23185998	23185998	+	Silent	SNP	G	A	A	rs146789742		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:23185998G>A	uc003xdh.1	-	6	1386	c.1047C>T	c.(1045-1047)ACC>ACT	p.T349T		NM_002318	NP_002309	Q9Y4K0	LOXL2_HUMAN	lysyl oxidase-like 2 precursor	349	SRCR 3.				aging|cell adhesion|protein modification process	extracellular space|membrane	copper ion binding|electron carrier activity|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|scavenger receptor activity			breast(2)|ovary(1)	3		Prostate(55;0.0453)|Breast(100;0.143)		Colorectal(74;0.0288)|COAD - Colon adenocarcinoma(73;0.096)		CGTCGCAGACGGTCCCCCATT	0.632000													21	85					0	0	1	0	0	
PPP2R2A	5520	broad.mit.edu	37	8	26218507	26218507	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:26218507T>C	uc003xeu.2	+	6	779	c.477T>C	c.(475-477)CCT>CCC	p.P159P	PPP2R2A_uc003xek.2_Intron|PPP2R2A_uc011laf.1_Silent_p.P169P	NM_002717	NP_002708	P63151	2ABA_HUMAN	alpha isoform of regulatory subunit B55, protein	159					protein dephosphorylation|signal transduction	protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity			ovary(1)|kidney(1)	2		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		TCTTTAGGCCTATGGATCTAA	0.328000													27	97					0	0	1	0	0	
PTK2B	2185	broad.mit.edu	37	8	27301752	27301752	+	Silent	SNP	G	A	A	rs144972819	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:27301752G>A	uc003xfn.1	+	28	2986	c.2178G>A	c.(2176-2178)CCG>CCA	p.P726P	PTK2B_uc003xfo.1_Silent_p.P726P|PTK2B_uc003xfp.1_Silent_p.P726P|PTK2B_uc003xfq.1_Silent_p.P726P|PTK2B_uc003xfr.1_Silent_p.P472P	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	726	Pro-rich.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		GACCCCCTCCGCAAACCAACC	0.537000													24	59					0	0	1	0	0	
CLU	1191	broad.mit.edu	37	8	27462724	27462724	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:27462724G>A	uc003xfw.1	-	4	604	c.546C>T	c.(544-546)CGC>CGT	p.R182R	CLU_uc010lux.1_Silent_p.R47R|CLU_uc003xfx.1_Silent_p.R182R|CLU_uc003xfy.1_Silent_p.R193R|CLU_uc003xfz.1_Silent_p.R234R	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	182					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TGCTGGACGCGCGGCTGAAGT	0.607000													13	60					0	0	1	0	0	
KCNU1	157855	broad.mit.edu	37	8	36691163	36691163	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:36691163C>G	uc010lvw.2	+	11	1285	c.1198C>G	c.(1198-1200)CTG>GTG	p.L400V	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	400	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GTGGGAGGATCTGAGGCGAGT	0.373000													7	49					0	0	1	0	0	
KCNU1	157855	broad.mit.edu	37	8	36793082	36793082	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:36793082C>A	uc010lvw.2	+	27	3181	c.3094C>A	c.(3094-3096)CTT>ATT	p.L1032I		NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1032	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GCCTTCAGATCTTGTGTTTTG	0.428000													48	99					9.52127e-25	1.02502e-24	1	1	0	
BRF2	55290	broad.mit.edu	37	8	37702233	37702233	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:37702233T>C	uc003xkk.2	-	4	1145	c.1035A>G	c.(1033-1035)TTA>TTG	p.L345L		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	345					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			TCCCCTGGGGTAAACCTAAGG	0.612000													19	38					0	0	1	0	0	
BRF2	55290	broad.mit.edu	37	8	37702549	37702549	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:37702549G>A	uc003xkk.2	-	4	829	c.719C>T	c.(718-720)GCA>GTA	p.A240V		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	240	2.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			AAGCCGATCTGCAGGCTGCAG	0.602000													15	31					0	0	1	0	0	
RAB11FIP1	80223	broad.mit.edu	37	8	37729779	37729779	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:37729779G>A	uc003xkm.1	-	4	2585	c.2541C>T	c.(2539-2541)AAC>AAT	p.N847N	RAB11FIP1_uc010lvz.1_Intron|RAB11FIP1_uc003xkn.1_Intron|RAB11FIP1_uc003xkl.1_Silent_p.N176N|RAB11FIP1_uc003xko.1_Silent_p.N176N|RAB11FIP1_uc003xkp.1_Intron	NM_001002814	NP_001002814	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 isoform 3	847					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CGTCAGACGCGTTTCCAGCAA	0.632000													27	78					0	0	1	0	0	
ANK1	286	broad.mit.edu	37	8	41519420	41519420	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:41519420C>T	uc003xok.2	-	41	5602	c.5518G>A	c.(5518-5520)GCC>ACC	p.A1840T	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Missense_Mutation_p.A994T|ANK1_uc003xoi.2_Missense_Mutation_p.A1840T|ANK1_uc003xoj.2_Missense_Mutation_p.A1840T|ANK1_uc003xol.2_Missense_Mutation_p.A1678T|ANK1_uc003xom.2_Missense_Mutation_p.A1881T|ANK1_uc011lcl.1_Missense_Mutation_p.A115T|ANK1_uc003xod.2_Missense_Mutation_p.A115T|ANK1_uc003xoc.2_Missense_Mutation_p.A115T|ANK1_uc003xof.2_Intron|MIR486_hsa-mir-486|MI0002470_5'Flank	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1840	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GCGGCATCGGCGCTGGACAAG	0.473000													22	74					0	0	1	0	0	
MYST3	7994	broad.mit.edu	37	8	41792210	41792210	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:41792210A>T	uc010lxb.2	-	18	4072	c.3528T>A	c.(3526-3528)AGT>AGA	p.S1176R	MYST3_uc010lxc.2_Missense_Mutation_p.S1176R|MYST3_uc003xon.3_Missense_Mutation_p.S1176R	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1176					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TGATTTCCCGACTCAACTTAA	0.463000													58	126					0	0	1	0	0	
MYST3	7994	broad.mit.edu	37	8	41906068	41906068	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:41906068A>C	uc010lxb.2	-	3	972	c.428T>G	c.(427-429)TTT>TGT	p.F143C	MYST3_uc010lxc.2_Missense_Mutation_p.F143C|MYST3_uc003xon.3_Missense_Mutation_p.F143C|MYST3_uc010lxd.2_Missense_Mutation_p.F143C	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	143	H15.|Required for activation of RUNX1-1.|Required for nuclear localization.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			CTGCTGGTGAAAGCCAGAGGC	0.478000													25	39					0	0	1	0	0	
SLC20A2	6575	broad.mit.edu	37	8	42294547	42294547	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:42294547C>T	uc010lxl.2	-	8	2177	c.1483G>A	c.(1483-1485)GCC>ACC	p.A495T	SLC20A2_uc010lxm.2_Missense_Mutation_p.A495T|SLC20A2_uc003xpe.2_Missense_Mutation_p.A495T|SLC20A2_uc011lcu.1_Missense_Mutation_p.A297T	NM_006749	NP_006740	Q08357	S20A2_HUMAN	solute carrier family 20, member 2	495	Helical; (Potential).				interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CCGAAACAGGCGGTGAGGACC	0.612000													13	54					0	0	1	0	0	
RNF170	81790	broad.mit.edu	37	8	42716955	42716955	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:42716955T>C	uc003xpo.2	-	6	917	c.440A>G	c.(439-441)CAG>CGG	p.Q147R	RNF170_uc011lcx.1_Intron|RNF170_uc010lxp.2_Missense_Mutation_p.Q63R|RNF170_uc003xpm.2_Missense_Mutation_p.Q147R|RNF170_uc003xpp.2_Missense_Mutation_p.Q51R|RNF170_uc003xpn.2_Missense_Mutation_p.Q51R|RNF170_uc003xpq.3_Missense_Mutation_p.Q147R	NM_001160223	NP_001153695	Q96K19	RN170_HUMAN	ring finger protein 170 isoform a	147						integral to membrane	zinc ion binding				0	all_lung(13;1.25e-11)|Lung NSC(13;3.55e-10)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00645)|Lung NSC(58;0.0176)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			CAGAACATCCTGAGACTGATC	0.338000													26	52					0	0	1	0	0	
PRKDC	5591	broad.mit.edu	37	8	48776075	48776075	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:48776075C>T	uc003xqi.2	-	43	5692	c.5635G>A	c.(5635-5637)GTG>ATG	p.V1879M	PRKDC_uc003xqj.2_Missense_Mutation_p.V1879M|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1879					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GAATACATCACGTCTAGAATC	0.333000								NHEJ					45	121					0	0	1	0	0	
PXDNL	137902	broad.mit.edu	37	8	52321350	52321350	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:52321350G>A	uc003xqu.3	-	17	2935	c.2834C>T	c.(2833-2835)GCG>GTG	p.A945V	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	945					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CTCCTGTCGCGCGCACTCGGT	0.652000													4	16					0	0	1	0	0	
FAM110B	90362	broad.mit.edu	37	8	59059293	59059293	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:59059293G>A	uc003xtj.1	+	5	1384	c.504G>A	c.(502-504)ACG>ACA	p.T168T		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	168						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TCTACCCCACGCAGGGCCGCA	0.692000													14	25					0	0	1	0	0	
CHD7	55636	broad.mit.edu	37	8	61734586	61734586	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:61734586C>T	uc003xue.2	+	11	3316	c.2839C>T	c.(2839-2841)CGA>TGA	p.R947*	CHD7_uc003xuf.2_Nonsense_Mutation_p.R60*	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	947	Chromo 2.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GAAACAGGAGCGACCTCCTGC	0.403000													9	42					0	0	1	0	0	
CHD7	55636	broad.mit.edu	37	8	61769311	61769311	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:61769311G>A	uc003xue.2	+	34	7949	c.7472G>A	c.(7471-7473)CGC>CAC	p.R2491H		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2491					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGCCTTTCGCGCACACCCACA	0.488000													52	140					0	0	1	0	0	
YTHDF3	253943	broad.mit.edu	37	8	64098806	64098806	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:64098806T>C	uc003xuy.2	+	5	553	c.237T>C	c.(235-237)GCT>GCC	p.A79A	YTHDF3_uc010lys.2_Silent_p.A23A|YTHDF3_uc003xuz.2_Silent_p.A23A|YTHDF3_uc003xva.2_Silent_p.A23A|YTHDF3_uc011len.1_Silent_p.A23A	NM_152758	NP_689971	Q7Z739	YTHD3_HUMAN	YTH domain family, member 3	79											0	Breast(64;0.0716)	all_cancers(86;0.169)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.146)	BRCA - Breast invasive adenocarcinoma(89;0.161)			GGTCCACAGCTGGAGACCAGC	0.443000													13	38					0	0	1	0	0	
BHLHE22	27319	broad.mit.edu	37	8	65493427	65493427	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:65493427C>T	uc003xvi.2	+	1	614	c.80C>T	c.(79-81)ACC>ATC	p.T27I	LOC401463_uc003xvh.2_Intron	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						AGCGCCTCCACCTCCAAGCGC	0.741000													3	10					0	0	1	0	0	
BHLHE22	27319	broad.mit.edu	37	8	65494354	65494354	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:65494354C>T	uc003xvi.2	+	1	1541	c.1007C>T	c.(1006-1008)CCG>CTG	p.P336L	LOC401463_uc003xvh.2_5'UTR	NM_152414	NP_689627	Q8NFJ8	BHE22_HUMAN	basic helix-loop-helix domain containing, class	336	Ala-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GCCCTGCACCCGGCGCTCGGC	0.721000													6	7					0	0	1	0	0	
DNAJC5B	85479	broad.mit.edu	37	8	66989096	66989096	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:66989096C>A	uc003xvs.1	+	4	612	c.321C>A	c.(319-321)AGC>AGA	p.S107R	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	107					protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			TGCTGTCGAGCTGGTGGGCAA	0.433000													31	81					5.45727e-16	5.79905e-16	1	1	0	
PRDM14	63978	broad.mit.edu	37	8	70981995	70981995	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:70981995G>A	uc003xym.2	-	2	303	c.101C>T	c.(100-102)CCG>CTG	p.P34L		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	34					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TCCATAGGACGGGAAAGGCGT	0.652000													3	23					0	0	1	0	0	
NCOA2	10499	broad.mit.edu	37	8	71074996	71074996	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:71074996G>A	uc003xyn.1	-	9	1088	c.926C>T	c.(925-927)GCG>GTG	p.A309V		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	309					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TTCATGCTGCGCATGGAACTT	0.448000			T	RUNXBP2	AML								42	108					0	0	1	0	0	
TRAM1	23471	broad.mit.edu	37	8	71495950	71495950	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:71495950G>A	uc003xyo.1	-	9	995	c.825C>T	c.(823-825)GGC>GGT	p.G275G	TRAM1_uc011lfc.1_Silent_p.G244G	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	275	Lumenal (Potential).|TLC.				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			CTCTTGCAAGGCCAAAACCAA	0.368000													39	139					0	0	1	0	0	
EYA1	2138	broad.mit.edu	37	8	72127878	72127878	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:72127878G>A	uc003xys.3	-	14	1733	c.1446C>T	c.(1444-1446)GCC>GCT	p.A482A	EYA1_uc003xyr.3_Silent_p.A447A|EYA1_uc003xyt.3_Silent_p.A449A|EYA1_uc010lzf.2_Silent_p.A409A|EYA1_uc003xyu.2_Silent_p.A482A|EYA1_uc011lfe.1_Silent_p.A476A|EYA1_uc003xyv.2_Silent_p.A360A	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	482					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			GTGCTTTCAGGGCCAGTGTCA	0.527000													27	83					0	0	1	0	0	
TRPA1	8989	broad.mit.edu	37	8	72964968	72964968	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:72964968G>A	uc003xza.2	-	14	1852	c.1677C>T	c.(1675-1677)GGC>GGT	p.G559G	uc011lff.1_RNA|uc003xyy.2_RNA	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	559	Cytoplasmic (Potential).|ANK 14.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTTTGGCGTGGCCTTCCCTTG	0.463000													33	104					0	0	1	0	0	
ZFHX4	79776	broad.mit.edu	37	8	77767850	77767850	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:77767850G>A	uc003yav.2	+	10	8945	c.8558G>A	c.(8557-8559)CGC>CAC	p.R2853H	ZFHX4_uc003yau.1_Missense_Mutation_p.R2898H|ZFHX4_uc003yaw.1_Missense_Mutation_p.R2853H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2853						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACGCCGACCGCAGCGAAACG	0.512000										HNSCC(33;0.089)			18	53					0	0	1	0	0	
RALYL	138046	broad.mit.edu	37	8	85799864	85799864	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:85799864G>C	uc003ycq.3	+	9	1127	c.711G>C	c.(709-711)GAG>GAC	p.E237D	RALYL_uc003ycr.3_Missense_Mutation_p.E237D|RALYL_uc003ycs.3_Missense_Mutation_p.E237D|RALYL_uc010lzy.2_Missense_Mutation_p.E226D|RALYL_uc003yct.3_Missense_Mutation_p.E250D|RALYL_uc003ycu.3_Missense_Mutation_p.E164D|RALYL_uc003ycv.3_Intron	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	237	Potential.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						AATTGGAAGAGAGTCTAGTGC	0.483000													34	81					0	0	1	0	0	
LRRCC1	85444	broad.mit.edu	37	8	86021867	86021867	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:86021867G>A	uc003ycw.2	+	2	296	c.142G>A	c.(142-144)GTC>ATC	p.V48I	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Intron|LRRCC1_uc003ycx.2_Intron|LRRCC1_uc003ycy.2_Missense_Mutation_p.V28I	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	48	LRR 1.				cell division|mitosis	centriole|nucleus					0						TCTTCATGCCGTCAATCTTCA	0.269000													5	21					0	0	1	0	0	
DCAF4L2	138009	broad.mit.edu	37	8	88886149	88886149	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:88886149C>A	uc003ydz.2	-	1	148	c.51G>T	c.(49-51)AAG>AAT	p.K17N		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	17										ovary(1)	1						CTCTGACTGTCTTTTTCTGCT	0.537000													18	50					1.15919e-05	1.1834e-05	1	1	0	
MMP16	4325	broad.mit.edu	37	8	89086899	89086899	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:89086899G>A	uc003yeb.3	-	7	1438	c.1156C>T	c.(1156-1158)CGG>TGG	p.R386W	MMP16_uc003yec.2_Missense_Mutation_p.R386W	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	386	Extracellular (Potential).|Hemopexin-like 1.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						GGCAAGCCCCGCCAGAAGTAA	0.433000													32	105					0	0	1	0	0	
OSGIN2	734	broad.mit.edu	37	8	90937019	90937019	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:90937019G>A	uc003yeg.2	+	6	1123	c.777G>A	c.(775-777)GCG>GCA	p.A259A	OSGIN2_uc003yeh.2_Silent_p.A303A	NM_004337	NP_004328	Q9Y236	OSGI2_HUMAN	oxidative stress induced growth inhibitor family	259					germ cell development|meiosis						0			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AGAATGTAGCGCTGGCAACTG	0.433000													22	71					0	0	1	0	0	
FAM92A1	137392	broad.mit.edu	37	8	94713478	94713478	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:94713478C>T	uc010maq.2	+	2	156	c.53C>T	c.(52-54)ACA>ATA	p.T18I	FAM92A1_uc003yfu.1_RNA|FAM92A1_uc003yfv.3_RNA	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	18											0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			CAACTGCAAACAGCTGTCTCA	0.453000													9	14					0	0	1	0	0	
INTS8	55656	broad.mit.edu	37	8	95837126	95837126	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:95837126G>A	uc003yhb.2	+	2	262	c.136G>A	c.(136-138)GCA>ACA	p.A46T	INTS8_uc003yha.1_Missense_Mutation_p.A46T|INTS8_uc011lgq.1_RNA|INTS8_uc011lgr.1_RNA	NM_017864	NP_060334	Q75QN2	INT8_HUMAN	integrator complex subunit 8	46					snRNA processing	integrator complex	protein binding				0	Breast(36;1.05e-06)					CCTAGATCCTGCACCAGTTCA	0.353000													14	49					0	0	1	0	0	
SDC2	6383	broad.mit.edu	37	8	97614732	97614732	+	Missense_Mutation	SNP	G	T	T	rs142924782		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:97614732G>T	uc003yhv.1	+	3	900	c.282G>T	c.(280-282)CAG>CAT	p.Q94H	SDC2_uc011lgu.1_Missense_Mutation_p.Q65H	NM_002998	NP_002989	P34741	SDC2_HUMAN	syndecan 2 precursor	94	Extracellular (Potential).					integral to plasma membrane	cytoskeletal protein binding|PDZ domain binding			ovary(2)	2	Breast(36;3.41e-05)				Sargramostim(DB00020)	TGAATATACAGAACAAGATAC	0.423000													33	87					3.03874e-20	3.25432e-20	1	1	0	
RGS22	26166	broad.mit.edu	37	8	101051172	101051172	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:101051172C>T	uc003yjb.1	-	14	2348	c.2153G>A	c.(2152-2154)TGC>TAC	p.C718Y	RGS22_uc003yja.1_Missense_Mutation_p.C537Y|RGS22_uc003yjc.1_Missense_Mutation_p.C706Y|RGS22_uc011lgz.1_RNA|RGS22_uc010mbo.1_RNA	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	718					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CGCTTGCTTGCATACTTTAAA	0.393000													11	47					0	0	1	0	0	
FBXO43	286151	broad.mit.edu	37	8	101146187	101146187	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:101146187A>G	uc003yjd.2	-	5	2683	c.1970T>C	c.(1969-1971)CTG>CCG	p.L657P	FBXO43_uc003yje.2_Missense_Mutation_p.L623P	NM_001029860	NP_001025031	Q4G163	FBX43_HUMAN	F-box protein 43 isoform b	657	IBR-type.				meiosis		zinc ion binding			kidney(1)|skin(1)	2	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TCGGCTACACAGTCCCCTTTT	0.448000													39	88					0	0	1	0	0	
GRHL2	79977	broad.mit.edu	37	8	102678915	102678915	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:102678915C>T	uc010mbu.2	+	16	2192	c.1862C>T	c.(1861-1863)ACG>ATG	p.T621M		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	621						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TTCAAGGTCACGCTCATGGAA	0.547000													27	52					0	0	1	0	0	
UBR5	51366	broad.mit.edu	37	8	103323682	103323682	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:103323682G>T	uc003ykr.1	-	20	2494	c.2461C>A	c.(2461-2463)CCA>ACA	p.P821T	UBR5_uc003yks.1_Missense_Mutation_p.P821T	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	821					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TTGGCCATTGGGTAGATGGTA	0.378000													44	87					2.01872e-29	2.18357e-29	1	1	0	
TM7SF4	81501	broad.mit.edu	37	8	105360884	105360884	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:105360884T>C	uc003ylx.1	+	2	153	c.104T>C	c.(103-105)GTT>GCT	p.V35A		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	35	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CATTTGGGAGTTTGCTGTTTG	0.517000													43	114					0	0	1	0	0	
LRP12	29967	broad.mit.edu	37	8	105509257	105509257	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:105509257A>G	uc003yma.2	-	5	1618	c.1523T>C	c.(1522-1524)CTC>CCC	p.L508P	LRP12_uc003ymb.2_Missense_Mutation_p.L489P|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	508	Helical; (Potential).				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGCTATGACGAGTAACAGGCC	0.458000													18	68					0	0	1	0	0	
KCNV1	27012	broad.mit.edu	37	8	110980553	110980553	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:110980553G>A	uc003ynr.3	-	3	1609	c.1267C>T	c.(1267-1269)CCT>TCT	p.P423S	KCNV1_uc010mcw.2_Missense_Mutation_p.P423S	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	423	Helical; Name=Segment S6; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			ATAGCAATAGGCAAGGCCAAG	0.448000													29	68					0	0	1	0	0	
CSMD3	114788	broad.mit.edu	37	8	113318290	113318290	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:113318290C>T	uc003ynu.2	-	51	8176	c.8017G>A	c.(8017-8019)GTA>ATA	p.V2673I	CSMD3_uc003yns.2_Missense_Mutation_p.V1875I|CSMD3_uc003ynt.2_Missense_Mutation_p.V2633I|CSMD3_uc011lhx.1_Missense_Mutation_p.V2569I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2673	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GATTGGCATACAGCTGTAGTG	0.393000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			69	154					0	0	1	0	0	
EXT1	2131	broad.mit.edu	37	8	118830694	118830694	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:118830694C>T	uc003yok.1	-	7	2385	c.1612G>A	c.(1612-1614)GTC>ATC	p.V538I		NM_000127	NP_000118	Q16394	EXT1_HUMAN	exostosin 1	538	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction|skeletal system development	Golgi membrane|integral to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|lung(2)	4	all_cancers(13;2.36e-26)|Lung NSC(37;5.02e-07)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.012)			CCTTCAATGACGACGACAGGC	0.527000			Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses|Langer-Giedion_syndrome				44	153					0	0	1	0	0	
ENPP2	5168	broad.mit.edu	37	8	120612982	120612982	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:120612982A>G	uc003yot.1	-	11	994	c.908T>C	c.(907-909)GTC>GCC	p.V303A	ENPP2_uc003yos.1_Missense_Mutation_p.V303A|ENPP2_uc010mdd.1_Missense_Mutation_p.V303A	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	303					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GAAGGCATAGACCGAAGGCCT	0.378000													20	74					0	0	1	0	0	
DEPDC6	64798	broad.mit.edu	37	8	121015280	121015280	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:121015280C>T	uc003yow.3	+	6	1042	c.855C>T	c.(853-855)GGC>GGT	p.G285G	DEPDC6_uc011lid.1_Silent_p.G184G	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	285	Ser-rich.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			gcagctgtggcagcagcggct	0.393000													5	16					0	0	1	0	0	
MTSS1	9788	broad.mit.edu	37	8	125565529	125565529	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:125565529T>C	uc003yrk.2	-	14	2506	c.1972A>G	c.(1972-1974)ACC>GCC	p.T658A	NDUFB9_uc011lim.1_Intron|MTSS1_uc003yrh.2_Missense_Mutation_p.T307A|MTSS1_uc011lin.1_Missense_Mutation_p.T432A|MTSS1_uc011lio.1_Missense_Mutation_p.T548A|MTSS1_uc003yri.2_Missense_Mutation_p.T376A|MTSS1_uc003yrj.2_Missense_Mutation_p.T633A|MTSS1_uc003yrl.2_Missense_Mutation_p.T662A	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	658	Pro-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GGCATGCTGGTGACACCTTGG	0.637000													26	97					0	0	1	0	0	
KIAA0196	9897	broad.mit.edu	37	8	126044624	126044624	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:126044624C>T	uc003yrt.2	-	27	3523	c.3194G>A	c.(3193-3195)CGA>CAA	p.R1065Q	KIAA0196_uc011lir.1_Missense_Mutation_p.R917Q|KIAA0196_uc003yru.1_Intron	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	1065					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			GGTCGGTTTTCGGCAGACCAT	0.507000													20	77					0	0	1	0	0	
MYC	4609	broad.mit.edu	37	8	128750777	128750777	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:128750777G>A	uc003ysh.1	+	3	782	c.269G>A	c.(268-270)GGC>GAC	p.G90D	MYC_uc003ysi.2_Missense_Mutation_p.G105D	NM_002467	NP_002458	P01106	MYC_HUMAN	myc proto-oncogene protein	90	Poly-Gly.				branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(3)|ovary(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		GACGGCGGTGGCGGGAGCTTC	0.677000		3	A|T	IGK@|BCL5|BCL7A |BTG1|TRA@|IGH@	Burkitt lymphoma| amplified in other cancers|B-CLL						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	32					0	0	1	0	0	
ASAP1	50807	broad.mit.edu	37	8	131149264	131149264	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:131149264C>T	uc003yta.1	-	13	1129	c.1101G>A	c.(1099-1101)AAG>AAA	p.K367K	ASAP1_uc003ysz.1_Silent_p.K178K|ASAP1_uc011liw.1_Silent_p.K360K	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	367	PH.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						GAAGGTTCAACTTGGCTGGTT	0.438000													31	110					0	0	1	0	0	
ADCY8	114	broad.mit.edu	37	8	131792669	131792669	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:131792669C>A	uc003ytd.3	-	18	3979	c.3723G>T	c.(3721-3723)CAG>CAT	p.Q1241H	ADCY8_uc010mds.2_Missense_Mutation_p.Q1110H	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1241	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TGCCTTCAGCCTGGGCTCCAG	0.363000										HNSCC(32;0.087)			29	96					2.81731e-10	2.93601e-10	1	1	0	
ADCY8	114	broad.mit.edu	37	8	131880110	131880110	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:131880110C>A	uc003ytd.3	-	9	2448	c.2192G>T	c.(2191-2193)AGT>ATT	p.S731I	ADCY8_uc010mds.2_Intron	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	731	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGGAAGCAAACTTTGTATTGC	0.353000										HNSCC(32;0.087)			16	70					4.7546e-09	4.93738e-09	1	1	0	
TG	7038	broad.mit.edu	37	8	133911046	133911046	+	Missense_Mutation	SNP	C	T	T	rs145085612		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:133911046C>T	uc003ytw.2	+	14	3262	c.3221C>T	c.(3220-3222)CCG>CTG	p.P1074L	TG_uc010mdw.2_5'UTR	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1074	Thyroglobulin type-1 9.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCACAGGCCCGACAACCTGC	0.343000													21	34					0	0	1	0	0	
ZFAT	57623	broad.mit.edu	37	8	135521887	135521887	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:135521887G>A	uc003yup.2	-	15	3642	c.3467C>T	c.(3466-3468)CCA>CTA	p.P1156L	ZFAT_uc011ljj.1_Missense_Mutation_p.P275L|ZFAT_uc003yun.2_Missense_Mutation_p.P1144L|ZFAT_uc003yuo.2_Missense_Mutation_p.P1144L|ZFAT_uc010meh.2_Intron|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.P1144L|ZFAT_uc010mej.2_Missense_Mutation_p.P1094L	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	1156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			CACCGTCCCTGGTGCCATGGC	0.577000													36	108					0	0	1	0	0	
COL22A1	169044	broad.mit.edu	37	8	139703108	139703108	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:139703108C>T	uc003yvd.2	-	36	3211	c.2764G>A	c.(2764-2766)GGA>AGA	p.G922R	COL22A1_uc011ljo.1_Missense_Mutation_p.G222R	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	922	Pro-rich.|Gly-rich.|Collagen-like 7.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.G922R(1)		ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCGACATGTCCGGGAGCACCC	0.532000										HNSCC(7;0.00092)			11	26					0	0	1	0	0	
EIF2C2	27161	broad.mit.edu	37	8	141561492	141561492	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:141561492C>T	uc003yvn.2	-	11	1353	c.1313G>A	c.(1312-1314)CGG>CAG	p.R438Q	EIF2C2_uc010men.2_Missense_Mutation_p.R361Q|EIF2C2_uc010meo.2_Missense_Mutation_p.R438Q	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	438					mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			CTGCTTGTTCCGCATGTCCCA	0.537000													38	128					0	0	1	0	0	
PTK2	5747	broad.mit.edu	37	8	141889676	141889676	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:141889676G>A	uc003yvu.2	-	4	486	c.256C>T	c.(256-258)CGC>TGC	p.R86C	PTK2_uc003yvr.2_5'UTR|PTK2_uc003yvs.2_Missense_Mutation_p.R86C|PTK2_uc003yvt.2_Missense_Mutation_p.R108C|PTK2_uc003yvv.2_Intron|PTK2_uc011ljr.1_Missense_Mutation_p.R86C	NM_153831	NP_722560	Q05397	FAK1_HUMAN	PTK2 protein tyrosine kinase 2 isoform a	86	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TGACTGAGGCGGAATCCATAG	0.502000													111	326					0	0	1	0	0	
DENND3	22898	broad.mit.edu	37	8	142178549	142178549	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:142178549A>G	uc003yvy.2	+	13	2238	c.1960A>G	c.(1960-1962)ATG>GTG	p.M654V	DENND3_uc010mep.2_Missense_Mutation_p.M615V|DENND3_uc003yvz.1_Missense_Mutation_p.M338V	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	654										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGCGACTTCATGAAGCGGGT	0.587000													27	89					0	0	1	0	0	
SLC45A4	57210	broad.mit.edu	37	8	142222398	142222398	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:142222398C>T	uc003ywd.1	-	7	2354	c.2046G>A	c.(2044-2046)CCG>CCA	p.P682P	SLC45A4_uc003ywc.1_Silent_p.P682P|SLC45A4_uc010meq.1_Silent_p.P680P	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	733					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CGCCGGCCAACGGGGAAGACA	0.637000													8	31					0	0	1	0	0	
SLC45A4	57210	broad.mit.edu	37	8	142222470	142222470	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:142222470C>T	uc003ywd.1	-	7	2282	c.1974G>A	c.(1972-1974)ACG>ACA	p.T658T	SLC45A4_uc003ywc.1_Silent_p.T658T|SLC45A4_uc010meq.1_Silent_p.T656T	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	709	Helical; (Potential).				transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGAATGTGGCCGTCAGGAAGC	0.657000													15	63					0	0	1	0	0	
FLJ43860	389690	broad.mit.edu	37	8	142446116	142446116	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:142446116G>A	uc003ywi.2	-	28	3533	c.3452C>T	c.(3451-3453)GCG>GTG	p.A1151V	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	1151							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGCCATGGCCGCCACCAGGTC	0.687000													6	32					0	0	1	0	0	
JRK	8629	broad.mit.edu	37	8	143745980	143745980	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:143745980C>T	uc003ywo.2	-	3	2010	c.1496G>A	c.(1495-1497)CGC>CAC	p.R499H	JRK_uc003ywp.2_Missense_Mutation_p.R499H|JRK_uc010mew.1_Missense_Mutation_p.A500T	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				ctccgcaaagcgcaggactgc	0.184000													7	12					0	0	1	0	0	
CYP11B2	1585	broad.mit.edu	37	8	143996616	143996616	+	Missense_Mutation	SNP	A	T	T	rs151052374		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:143996616A>T	uc003yxk.1	-	3	444	c.441T>A	c.(439-441)GAT>GAA	p.D147E		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	147					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GCGACAGCACATCTGGGTTCA	0.627000									Familial_Hyperaldosteronism_type_I				4	38					0	0	1	0	0	
TOP1MT	116447	broad.mit.edu	37	8	144397975	144397975	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:144397975T>C	uc003yxz.2	-	12	1494	c.1475A>G	c.(1474-1476)GAG>GGG	p.E492G	TOP1MT_uc011lkd.1_Missense_Mutation_p.E394G|TOP1MT_uc011lke.1_Missense_Mutation_p.E394G|TOP1MT_uc010mfb.2_Missense_Mutation_p.E394G|TOP1MT_uc011lkf.1_Missense_Mutation_p.E287G	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	492					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	AGCCACCTGCTCCTTCTTTGC	0.652000													23	47					0	0	1	0	0	
RHPN1	114822	broad.mit.edu	37	8	144463997	144463997	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:144463997C>T	uc003yyb.2	+	14	1789	c.1656C>T	c.(1654-1656)GGC>GGT	p.G552G		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	577	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			TGAAGGAGGGCGACTACATTG	0.682000													9	31					0	0	1	0	0	
SCRIB	23513	broad.mit.edu	37	8	144885638	144885638	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:144885638G>A	uc003yzp.1	-	24	3525	c.3518C>T	c.(3517-3519)GCG>GTG	p.A1173V	SCRIB_uc003yzn.1_5'UTR|SCRIB_uc003yzo.1_Missense_Mutation_p.A1173V	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	scribble isoform b	1173	PDZ 4.|Interaction with ARHGEF7.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)|pancreas(1)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CAGCTGCACCGCCTCGCCGTG	0.706000													5	22					0	0	1	0	0	
EPPK1	83481	broad.mit.edu	37	8	144940551	144940551	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:144940551C>T	uc003zaa.1	-	2	14894	c.14881G>A	c.(14881-14883)GTG>ATG	p.V4961M		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	4961	Plectin 62.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCGCCCACCACGCCCGCGGCC	0.721000													7	150					0	0	1	0	0	
EPPK1	83481	broad.mit.edu	37	8	144945127	144945127	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:144945127C>T	uc003zaa.1	-	1	2308	c.2295G>A	c.(2293-2295)AAG>AAA	p.K765K		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	765	Plectin 15.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGAAGAAGCCCTTGGTGTCGT	0.627000													37	146					0	0	1	0	0	
PLEC	5339	broad.mit.edu	37	8	144991738	144991738	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:144991738G>A	uc003zaf.1	-	32	12832	c.12662C>T	c.(12661-12663)TCG>TTG	p.S4221L	PLEC_uc003zab.1_Missense_Mutation_p.S4084L|PLEC_uc003zac.1_Missense_Mutation_p.S4088L|PLEC_uc003zad.2_Missense_Mutation_p.S4084L|PLEC_uc003zae.1_Missense_Mutation_p.S4052L|PLEC_uc003zag.1_Missense_Mutation_p.S4062L|PLEC_uc003zah.2_Missense_Mutation_p.S4070L|PLEC_uc003zaj.2_Missense_Mutation_p.S4111L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4221	Plectin 26.|Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GGTGTCGTCCGAGGGGTCGGT	0.612000													36	70					0	0	1	0	0	
PLEC	5339	broad.mit.edu	37	8	144998487	144998487	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:144998487C>T	uc003zaf.1	-	31	6191	c.6021G>A	c.(6019-6021)GCG>GCA	p.A2007A	PLEC_uc003zab.1_Silent_p.A1870A|PLEC_uc003zac.1_Silent_p.A1874A|PLEC_uc003zad.2_Silent_p.A1870A|PLEC_uc003zae.1_Silent_p.A1838A|PLEC_uc003zag.1_Silent_p.A1848A|PLEC_uc003zah.2_Silent_p.A1856A|PLEC_uc003zaj.2_Silent_p.A1897A	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2007	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CCTCGTCCTCCGCCAGCCGCC	0.706000													8	20					0	0	1	0	0	
PARP10	84875	broad.mit.edu	37	8	145051982	145051982	+	Silent	SNP	C	T	T	rs141748737		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145051982C>T	uc003zal.3	-	11	2856	c.2748G>A	c.(2746-2748)AAG>AAA	p.K916K	PLEC_uc003zaj.2_5'Flank|PARP10_uc003zak.3_Silent_p.K613K|PARP10_uc011lku.1_Silent_p.K928K|PARP10_uc011lkv.1_RNA	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	916	PARP catalytic.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AATACACGCCCTTCCCGTAGA	0.711000													8	16					0	0	1	0	0	
PARP10	84875	broad.mit.edu	37	8	145059956	145059956	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145059956G>A	uc003zal.3	-	3	477	c.369C>T	c.(367-369)TGC>TGT	p.C123C	PARP10_uc003zak.3_5'Flank|PARP10_uc011lku.1_Silent_p.C135C|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Silent_p.C123C|PARP10_uc010mfn.1_Intron|PARP10_uc010mfo.1_Missense_Mutation_p.A16V	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	123						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCAAGGCACAGCAAGGCTGTA	0.687000													13	45					0	0	1	0	0	
SPATC1	375686	broad.mit.edu	37	8	145101650	145101650	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145101650G>A	uc011lkw.1	+	5	1671	c.1569G>A	c.(1567-1569)GCG>GCA	p.A523A	SPATC1_uc011lkx.1_3'UTR	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	523										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGCACCCTGCGCTGACCGAGC	0.642000													21	53					0	0	1	0	0	
OPLAH	26873	broad.mit.edu	37	8	145113475	145113475	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145113475C>A	uc003zar.3	-	6	789	c.707G>T	c.(706-708)TGT>TTT	p.C236F	OPLAH_uc003zat.1_Missense_Mutation_p.C14F	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	236							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GGCGTCGGCACAGGCCGTGTG	0.687000													12	35					7.03913e-09	7.29497e-09	1	1	0	
CPSF1	29894	broad.mit.edu	37	8	145619493	145619493	+	Missense_Mutation	SNP	T	C	C	rs141624286		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145619493T>C	uc003zcj.2	-	33	3842	c.3767A>G	c.(3766-3768)TAC>TGC	p.Y1256C	MIR939_hsa-mir-939|MI0005761_5'Flank	NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	1256					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding	p.Y1256C(1)		skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			GTCCACGCTGTACACCTCCAG	0.677000													8	23					0	0	1	0	0	
CPSF1	29894	broad.mit.edu	37	8	145623706	145623706	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145623706C>T	uc003zcj.2	-	19	1955	c.1880G>A	c.(1879-1881)CGC>CAC	p.R627H		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	627					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			TTCCAGCAGGCGGATGCCCAG	0.662000													32	89					0	0	1	0	0	
SLC39A4	55630	broad.mit.edu	37	8	145640738	145640738	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145640738G>A	uc003zcq.2	-	3	640	c.540C>T	c.(538-540)GGC>GGT	p.G180G	SLC39A4_uc003zcm.1_5'Flank|SLC39A4_uc003zcn.2_5'Flank|SLC39A4_uc003zco.2_5'UTR|SLC39A4_uc003zcp.2_Silent_p.G155G	NM_130849	NP_570901	Q6P5W5	S39A4_HUMAN	solute carrier family 39 (zinc transporter),	180	Extracellular (Potential).					cytoplasmic membrane-bounded vesicle|integral to membrane|recycling endosome membrane	zinc ion transmembrane transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;1.12e-40)|all cancers(56;8.17e-36)|BRCA - Breast invasive adenocarcinoma(115;0.0407)|Colorectal(110;0.055)			CCAGGACGCCGCCAGCACTGC	0.667000													3	17					0	0	1	0	0	
MFSD3	113655	broad.mit.edu	37	8	145735316	145735316	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145735316C>A	uc003zdi.1	+	1	765	c.600C>A	c.(598-600)CCC>CCA	p.P200P		NM_138431	NP_612440	Q96ES6	MFSD3_HUMAN	major facilitator superfamily domain containing	200	Leu-rich.				transmembrane transport	integral to membrane				central_nervous_system(2)	2	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			AGCAGCGTCCCCACACCGCGC	0.706000											OREG0019059	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	12					1	1	1	1	0	
ARHGAP39	80728	broad.mit.edu	37	8	145757727	145757727	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:145757727C>T	uc003zdt.1	-	10	3404	c.2849G>A	c.(2848-2850)TGG>TAG	p.W950*	ARHGAP39_uc011llk.1_Nonsense_Mutation_p.W950*|ARHGAP39_uc003zds.1_Nonsense_Mutation_p.W981*	NM_025251	NP_079527	Q9C0H5	RHG39_HUMAN	KIAA1688 protein	950	Rho-GAP.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity				0						GGGCACCTTCCACTGGTCCAC	0.667000													19	44					0	0	1	0	0	
CBWD1	55871	broad.mit.edu	37	9	164038	164038	+	Splice_Site	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:164038C>G	uc003zga.3	-	5	537	c.431_splice	c.e5-1	p.G144_splice	CBWD1_uc010mgs.2_Splice_Site|CBWD1_uc003zgb.3_Splice_Site_p.G108_splice|CBWD1_uc003zgc.3_Splice_Site_p.G144_splice|CBWD1_uc011llr.1_Splice_Site_p.G108_splice	NM_018491	NP_060961	Q9BRT8	CBWD1_HUMAN	COBW domain containing 1 isoform 1								ATP binding|protein binding			ovary(1)	1	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCCACTGCACCTGAAAATATA	0.269000													14	130					0	0	1	0	0	
DMRT1	1761	broad.mit.edu	37	9	847112	847112	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:847112G>A	uc003zgv.2	+	2	656	c.507G>A	c.(505-507)CCG>CCA	p.P169P	DMRT1_uc003zgu.1_Silent_p.P169P	NM_021951	NP_068770	Q9Y5R6	DMRT1_HUMAN	doublesex and mab-3 related transcription factor	169					cell differentiation|male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(10;2.66e-10)|Lung NSC(10;2.82e-10)|Breast(48;0.232)		Lung(218;0.037)		CTCAGCCACCGCCGGCCAGTG	0.617000													22	32					0	0	1	0	0	
SMARCA2	6595	broad.mit.edu	37	9	2123753	2123753	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:2123753G>A	uc003zhc.2	+	27	3896	c.3797G>A	c.(3796-3798)CGG>CAG	p.R1266Q	SMARCA2_uc003zhd.2_Missense_Mutation_p.R1266Q|SMARCA2_uc010mha.2_Missense_Mutation_p.R1199Q	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1266					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GAAGATGCCCGGAACCCGAAA	0.542000													11	15					0	0	1	0	0	
ADAMTSL1	92949	broad.mit.edu	37	9	18777506	18777506	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:18777506C>T	uc003zne.3	+	19	3406	c.3279C>T	c.(3277-3279)CGC>CGT	p.R1093R		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1093						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		AGGAGCTGCGCGACCTCTACA	0.667000													7	7					0	0	1	0	0	
HAUS6	54801	broad.mit.edu	37	9	19070224	19070224	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:19070224C>T	uc003znk.2	-	12	1622	c.1369G>A	c.(1369-1371)GCC>ACC	p.A457T	HAUS6_uc011lmz.1_Missense_Mutation_p.A177T|HAUS6_uc003znl.1_Missense_Mutation_p.A321T|HAUS6_uc003znm.1_Missense_Mutation_p.A212T	NM_017645	NP_060115	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	457					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				ovary(2)	2						TACCTGTTGGCTAGATCATGT	0.274000													9	13					0	0	1	0	0	
ACER2	340485	broad.mit.edu	37	9	19450475	19450475	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:19450475C>T	uc003zny.1	+	6	827	c.669C>T	c.(667-669)TAC>TAT	p.Y223Y	ACER2_uc003znx.1_RNA|ACER2_uc003znz.1_Silent_p.Y174Y	NM_001010887	NP_001010887	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	223	Helical; (Potential).				ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2						TTGCTGCCTACCTGGGCTGTG	0.532000													45	66					0	0	1	0	0	
ELAVL2	1993	broad.mit.edu	37	9	23692861	23692861	+	Silent	SNP	G	A	A	rs138657080	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:23692861G>A	uc003zpu.2	-	7	1049	c.774C>T	c.(772-774)GAC>GAT	p.D258D	ELAVL2_uc003zps.2_Silent_p.D245D|ELAVL2_uc003zpt.2_Silent_p.D245D|ELAVL2_uc003zpv.2_Silent_p.D258D|ELAVL2_uc003zpw.2_Silent_p.D245D	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	258					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TGGTCATTCCGTCAATGGTCA	0.423000													15	31					0	0	1	0	0	
C9orf82	79886	broad.mit.edu	37	9	26884837	26884837	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:26884837A>G	uc003zqc.2	-	4	648	c.636T>C	c.(634-636)GGT>GGC	p.G212G	C9orf82_uc003zqb.2_Silent_p.G67G	NM_024828	NP_079104	Q9H8G2	CI082_HUMAN	hypothetical protein LOC79886	212											0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(42;1.39e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		CCATCTTAGAACCATCATCTG	0.299000													60	115					0	0	1	0	0	
DDX58	23586	broad.mit.edu	37	9	32487537	32487537	+	Missense_Mutation	SNP	G	A	A	rs139635230		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:32487537G>A	uc003zra.2	-	9	1465	c.1307C>T	c.(1306-1308)GCG>GTG	p.A436V	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Missense_Mutation_p.A391V|DDX58_uc011lnr.1_Missense_Mutation_p.A233V|DDX58_uc010mji.2_Missense_Mutation_p.A365V	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	436					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		TATCACTGACGCATCAAGAGA	0.453000													25	51					0	0	1	0	0	
TOPORS	10210	broad.mit.edu	37	9	32541935	32541935	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:32541935C>T	uc003zrb.2	-	3	2755	c.2588G>A	c.(2587-2589)CGG>CAG	p.R863Q	TOPORS_uc003zrc.2_Missense_Mutation_p.R796Q	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	863	Lys-rich.|Interaction with UBE2I.|Interaction with TOP1.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ACTTAGGCTCCGGGTCTTCCT	0.313000													64	119					0	0	1	0	0	
ARID3C	138715	broad.mit.edu	37	9	34623962	34623962	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:34623962G>A	uc011lon.1	-	3	474	c.474C>T	c.(472-474)GGC>GGT	p.G158G		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	158	ARID.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CCACCAGGCCGCCCTTGGCGG	0.662000													7	7					0	0	1	0	0	
SPAG8	26206	broad.mit.edu	37	9	35810882	35810882	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:35810882C>T	uc003zye.2	-	3	1152	c.1037G>A	c.(1036-1038)CGA>CAA	p.R346Q	SPAG8_uc003zyf.2_Missense_Mutation_p.R263Q|SPAG8_uc003zyg.2_Missense_Mutation_p.R346Q	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	346						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			TTTCACACCTCGAAGTGGCCA	0.532000													23	38					0	0	1	0	0	
SPAG8	26206	broad.mit.edu	37	9	35811334	35811334	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:35811334A>G	uc003zye.2	-	2	824	c.709T>C	c.(709-711)TGG>CGG	p.W237R	SPAG8_uc003zyf.2_Missense_Mutation_p.W154R|SPAG8_uc003zyg.2_Missense_Mutation_p.W237R	NM_172312	NP_758516	Q99932	SPAG8_HUMAN	sperm associated antigen 8 isoform 2	237						acrosomal vesicle|membrane				ovary(1)	1	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			TGGGGCTCCCAGGGGCAGTGC	0.547000													74	132					0	0	1	0	0	
FRMPD1	22844	broad.mit.edu	37	9	37740863	37740863	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:37740863C>T	uc004aag.1	+	15	2382	c.2338C>T	c.(2338-2340)CCC>TCC	p.P780S	FRMPD1_uc004aah.1_Missense_Mutation_p.P780S|FRMPD1_uc011lqm.1_Missense_Mutation_p.P602S|FRMPD1_uc011lqn.1_Missense_Mutation_p.P649S	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	780						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TAAGCTCACTCCCCCAGGCCC	0.642000													17	27					0	0	1	0	0	
IGFBPL1	347252	broad.mit.edu	37	9	38411500	38411500	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:38411500G>A	uc004aba.2	-	4	757	c.734C>T	c.(733-735)GCA>GTA	p.A245V		NM_001007563	NP_001007564	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like	245	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding				0				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		CATGTTGGCTGCATGGCACTG	0.493000													16	31					0	0	1	0	0	
Unknown	0	broad.mit.edu	37	9	43737470	43737470	+	RNA	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:43737470A>G	uc004acz.1	+	3		c.572A>G								Homo sapiens cDNA FLJ30083 fis, clone BGGI12001097, weakly similar to Homo sapiens contactin associated protein (Caspr) mRNA.																		CCTGATGTTCAGTGATGGTGG	0.478000													50	64					0	0	1	0	0	
FAM75A5	727905	broad.mit.edu	37	9	65506469	65506469	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:65506469C>T	uc004adx.3	-	4	1120	c.1091G>A	c.(1090-1092)CGG>CAG	p.R364Q		NM_015667	NP_056482	Q5VU36	F75A5_HUMAN	hypothetical protein LOC26165	364						integral to membrane					0						AGCCAAATTCCGCAAATAATT	0.433000													128	37					0	0	1	0	0	
FOXD4L5	653427	broad.mit.edu	37	9	70177122	70177122	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:70177122C>T	uc010moc.2	-	1	1694	c.862G>A	c.(862-864)GCG>ACG	p.A288T		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	288					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GCCAGGTCCGCGCCTTCTGCT	0.687000													21	80					0	0	1	0	0	
CBWD3	445571	broad.mit.edu	37	9	70490121	70490121	+	Translation_Start_Site	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:70490121G>A	uc004aga.3	-	1	57	c.-52C>T	c.(-54--50)TACGG>TATGG		CBWD3_uc004agc.3_RNA|CBWD3_uc004afy.3_RNA|CBWD3_uc011lrm.1_Translation_Start_Site|CBWD3_uc011lrn.1_RNA|CBWD3_uc004agb.3_Translation_Start_Site|CBWD3_uc010moe.1_RNA|CBWD3_uc004agd.1_Intron|CBWD3_uc004age.2_Translation_Start_Site	NM_201453	NP_958861	Q5JTY5	CBWD3_HUMAN	COBW domain containing 3								ATP binding				0				all cancers(8;0.00136)|Epithelial(8;0.0288)|GBM - Glioblastoma multiforme(74;0.0402)|OV - Ovarian serous cystadenocarcinoma(323;0.18)		CCAACACGCCGTACCGCAGCC	0.662000													24	35					0	0	1	0	0	
PGM5	5239	broad.mit.edu	37	9	70993145	70993145	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:70993145A>G	uc004agr.2	+	2	521	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	98					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						ACAGAATGGCATCTTGTCGAC	0.478000													14	96					0	0	1	0	0	
PRKACG	5568	broad.mit.edu	37	9	71628114	71628114	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:71628114C>T	uc004agy.2	-	1	926	c.895G>A	c.(895-897)GCC>ACC	p.A299T		NM_002732	NP_002723	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic,	299	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			ovary(1)|pancreas(1)|skin(1)	3						CTGGTTGTGGCGAACCACTTG	0.567000													42	66					0	0	1	0	0	
ZFAND5	7763	broad.mit.edu	37	9	74975132	74975132	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:74975132C>T	uc004aiv.2	-	3	435	c.157G>A	c.(157-159)GCT>ACT	p.A53T	ZFAND5_uc010mox.1_5'UTR|ZFAND5_uc010moy.1_Missense_Mutation_p.A53T|ZFAND5_uc004aix.2_Missense_Mutation_p.A53T|ZFAND5_uc004aiw.2_Missense_Mutation_p.A53T|ZFAND5_uc004aiy.2_Missense_Mutation_p.A53T	NM_006007	NP_005998	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	53							DNA binding|zinc ion binding				0						GAACCACTAGCTGTTCCTATT	0.378000													29	60					0	0	1	0	0	
PRUNE2	158471	broad.mit.edu	37	9	79328535	79328535	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:79328535G>C	uc010mpk.2	-	7	983	c.859C>G	c.(859-861)CAG>GAG	p.Q287E		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	287					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						CTCGGCTGCTGCTCCTCTGAC	0.483000													6	12					0	0	1	0	0	
VPS13A	23230	broad.mit.edu	37	9	79985472	79985472	+	Missense_Mutation	SNP	G	A	A	rs138767500		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:79985472G>A	uc004akr.2	+	65	9145	c.8885G>A	c.(8884-8886)CGT>CAT	p.R2962H	VPS13A_uc004akp.3_Missense_Mutation_p.R2962H|VPS13A_uc004akq.3_Missense_Mutation_p.R2962H|VPS13A_uc004aks.2_Missense_Mutation_p.R2923H	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2962					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						GGCATCACTCGTGGAGGAAAA	0.403000													37	50					0	0	1	0	0	
TLE4	7091	broad.mit.edu	37	9	82323523	82323523	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:82323523C>T	uc004ald.2	+	14	2009	c.1160C>T	c.(1159-1161)ACC>ATC	p.T387I	TLE4_uc004alc.2_Missense_Mutation_p.T362I|TLE4_uc010mpr.2_Missense_Mutation_p.T241I|TLE4_uc004ale.2_5'UTR|TLE4_uc011lsq.1_Missense_Mutation_p.T330I|TLE4_uc010mps.2_Missense_Mutation_p.T286I|TLE4_uc004alf.2_Missense_Mutation_p.T301I	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						AGCCTAAGGACCCCAATGGCA	0.483000													44	82					0	0	1	0	0	
HNRNPK	3190	broad.mit.edu	37	9	86585140	86585140	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:86585140C>A	uc004ang.3	-	16	1522	c.1298G>T	c.(1297-1299)CGG>CTG	p.R433L	HNRNPK_uc011lsw.1_Missense_Mutation_p.R193L|HNRNPK_uc004and.3_Missense_Mutation_p.R193L|HNRNPK_uc004ank.3_Missense_Mutation_p.R432L|HNRNPK_uc004anf.3_Missense_Mutation_p.R433L|HNRNPK_uc004anh.3_Missense_Mutation_p.R409L|HNRNPK_uc011lsx.1_Missense_Mutation_p.R409L|HNRNPK_uc004ani.3_Missense_Mutation_p.R432L|HNRNPK_uc004anj.3_Missense_Mutation_p.R432L|HNRNPK_uc004ann.3_Missense_Mutation_p.R408L|HNRNPK_uc004anl.3_Missense_Mutation_p.R433L|HNRNPK_uc004anm.3_Missense_Mutation_p.R433L|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	433	KH 3.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GGTAATGATCCGATCTTCGGA	0.413000													36	58					3.78316e-11	3.96671e-11	1	1	0	
NTRK2	4915	broad.mit.edu	37	9	87342787	87342787	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:87342787G>T	uc004aoa.1	+	11	2010	c.1072G>T	c.(1072-1074)GAC>TAC	p.D358Y	NTRK2_uc004anv.1_Missense_Mutation_p.D345Y|NTRK2_uc004any.1_Missense_Mutation_p.D358Y|NTRK2_uc004anz.1_Missense_Mutation_p.D358Y|NTRK2_uc011lsz.1_Missense_Mutation_p.D358Y|NTRK2_uc011lta.1_Missense_Mutation_p.D358Y|NTRK2_uc004aob.1_Missense_Mutation_p.D358Y|NTRK2_uc011ltb.1_Missense_Mutation_p.D202Y	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	358	Extracellular (Potential).|Ig-like C2-type 2.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						GAACAATGGGGACTACACTCT	0.453000										TSP Lung(25;0.17)			33	52					2.20262e-25	2.37499e-25	1	1	0	
SHC3	53358	broad.mit.edu	37	9	91652963	91652963	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:91652963G>A	uc004aqg.2	-	11	1908	c.1601C>T	c.(1600-1602)ACG>ATG	p.T534M		NM_016848	NP_058544	Q92529	SHC3_HUMAN	src homology 2 domain-containing transforming	534	SH2.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			lung(3)|skin(1)	4						GTGCATGCCCGTGAGGACAAA	0.642000													52	91					0	0	1	0	0	
SEMA4D	10507	broad.mit.edu	37	9	92011709	92011709	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:92011709G>A	uc004aqo.1	-	8	929	c.357C>T	c.(355-357)AGC>AGT	p.S119S	SEMA4D_uc011ltm.1_Silent_p.S119S|SEMA4D_uc011ltn.1_RNA|SEMA4D_uc011lto.1_RNA|SEMA4D_uc004aqp.1_Silent_p.S117S	NM_006378	NP_006369	Q92854	SEM4D_HUMAN	semaphorin 4D isoform 1	119	Sema.|Extracellular (Potential).				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			ovary(1)|pancreas(1)	2						GGGAAGTGGCGCTGAGTGGCT	0.597000													8	17					0	0	1	0	0	
SYK	6850	broad.mit.edu	37	9	93640023	93640023	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:93640023C>T	uc004aqz.2	+	10	1557	c.1352C>T	c.(1351-1353)GCA>GTA	p.A451V	SYK_uc004ara.2_Missense_Mutation_p.A428V|SYK_uc004arb.2_Missense_Mutation_p.A428V|SYK_uc004arc.2_Missense_Mutation_p.A451V|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	451	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						ATGGAGATGGCAGAACTTGGT	0.542000			T	ETV6|ITK	MDS|peripheral T-cell lymphoma								14	51					0	0	1	0	0	
NOL8	55035	broad.mit.edu	37	9	95077846	95077846	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:95077846A>G	uc004arv.2	-	7	1398	c.1061T>C	c.(1060-1062)TTA>TCA	p.L354S	NOL8_uc010mqw.2_RNA|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.L286S	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	354					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						TTTGATACCTAAACCTATTAA	0.353000													10	12					0	0	1	0	0	
WNK2	65268	broad.mit.edu	37	9	96055347	96055347	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:96055347C>T	uc004ati.1	+	23	5711	c.5711C>T	c.(5710-5712)ACG>ATG	p.T1904M	WNK2_uc011lud.1_Missense_Mutation_p.T1867M|WNK2_uc004atj.2_Missense_Mutation_p.T1867M|WNK2_uc004atk.2_Missense_Mutation_p.T1504M|WNK2_uc004atl.1_Missense_Mutation_p.T461M	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1904					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						AAGGTCCCCACGATCAGCGTG	0.612000													21	22					0	0	1	0	0	
FAM120A	23196	broad.mit.edu	37	9	96278450	96278450	+	Silent	SNP	G	A	A	rs138093719		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:96278450G>A	uc004atw.2	+	7	1342	c.1317G>A	c.(1315-1317)CCG>CCA	p.P439P	FAM120A_uc004atv.2_Silent_p.P439P|FAM120A_uc004atx.2_Silent_p.P221P|FAM120A_uc004aty.2_Silent_p.P220P|FAM120A_uc004atz.2_Silent_p.P88P|FAM120A_uc010mrf.1_RNA	NM_014612	NP_055427	Q9NZB2	F120A_HUMAN	oxidative stress-associated Src activator	439						cytoplasm|plasma membrane	RNA binding				0						CCATCAACCCGGCCCAGAGCG	0.607000													33	39					0	0	1	0	0	
ZNF169	169841	broad.mit.edu	37	9	97063255	97063255	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:97063255C>T	uc004aum.1	+	5	1520	c.1415C>T	c.(1414-1416)ACC>ATC	p.T472I		NM_194320	NP_919301	Q14929	ZN169_HUMAN	zinc finger protein 169	472	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.136)				CAGAAGGTCACCCTCATCAGA	0.567000													17	48					0	0	1	0	0	
OR13C4	138804	broad.mit.edu	37	9	107289041	107289041	+	Silent	SNP	A	G	G	rs141582176	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:107289041A>G	uc011lvn.1	-	1	450	c.450T>C	c.(448-450)CTT>CTC	p.L150L		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	150	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTCCACCAGAAAGCCATGATA	0.423000													53	66					0	0	1	0	0	
ABCA1	19	broad.mit.edu	37	9	107586833	107586833	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:107586833A>G	uc004bcl.2	-	18	2882	c.2569T>C	c.(2569-2571)TAT>CAT	p.Y857H		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	857					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CAAGGAAAATACCAGGGCCTG	0.502000													16	25					0	0	1	0	0	
ZNF462	58499	broad.mit.edu	37	9	109687846	109687846	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:109687846A>G	uc004bcz.2	+	3	1942	c.1653A>G	c.(1651-1653)CCA>CCG	p.P551P	ZNF462_uc010mto.2_Silent_p.P399P|ZNF462_uc004bda.2_Silent_p.P399P	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	551					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						cgccgccgccaccaccaccat	0.438000													7	14					0	0	1	0	0	
ZNF462	58499	broad.mit.edu	37	9	109689202	109689202	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:109689202G>A	uc004bcz.2	+	3	3298	c.3009G>A	c.(3007-3009)ACG>ACA	p.T1003T	ZNF462_uc010mto.2_Silent_p.T851T|ZNF462_uc004bda.2_Silent_p.T851T	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1003					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TGCCAGCTACGTTCAACAAAA	0.458000													73	68					0	0	1	0	0	
ZNF462	58499	broad.mit.edu	37	9	109746636	109746636	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:109746636C>T	uc004bcz.2	+	10	7291	c.7002C>T	c.(7000-7002)TAC>TAT	p.Y2334Y	ZNF462_uc010mto.2_Silent_p.Y2243Y|ZNF462_uc004bda.2_Silent_p.Y2242Y|ZNF462_uc011lvz.1_Silent_p.Y291Y|uc004bdc.1_Intron	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2334	C2H2-type 26.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AGCTCTGCTACTATGAGACCA	0.507000													23	53					0	0	1	0	0	
ACTL7A	10881	broad.mit.edu	37	9	111625268	111625268	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:111625268C>T	uc004bdj.1	+	1	666	c.666C>T	c.(664-666)GGC>GGT	p.G222G		NM_006687	NP_006678	Q9Y615	ACL7A_HUMAN	actin-like 7A	222						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton				0						TGGGCCATGGCGTGTCCTACG	0.617000													32	34					0	0	1	0	0	
EPB41L4B	54566	broad.mit.edu	37	9	112017946	112017946	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:112017946C>T	uc004bdz.1	-	11	1309	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	EPB41L4B_uc004bea.2_Silent_p.E338E	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	338	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						CAAACGTGTGCTCTTGCTCAC	0.547000													35	71					0	0	1	0	0	
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899061	112899061	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:112899061C>T	uc004bei.2	+	9	2125	c.1933C>T	c.(1933-1935)CGT>TGT	p.R645C	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.R413C|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.R413C|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.R223C|AKAP2_uc011lwi.1_Missense_Mutation_p.R271C|AKAP2_uc004bem.2_Missense_Mutation_p.R271C|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.R231C|AKAP2_uc011lwj.1_Missense_Mutation_p.R182C|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.R182C	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	182							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						GTTTGAGCTGCGTGCCTTCCA	0.517000													24	36					0	0	1	0	0	
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899946	112899946	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:112899946G>A	uc004bei.2	+	9	3010	c.2818G>A	c.(2818-2820)GAA>AAA	p.E940K	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.E708K|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.E708K|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.E518K|AKAP2_uc011lwi.1_Missense_Mutation_p.E566K|AKAP2_uc004bem.2_Missense_Mutation_p.E566K|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.E526K|AKAP2_uc011lwj.1_Missense_Mutation_p.E477K|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.E477K	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	477							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TGGTCTGGACGAATTGTCGGT	0.498000													47	67					0	0	1	0	0	
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900545	112900545	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:112900545C>T	uc004bei.2	+	9	3609	c.3417C>T	c.(3415-3417)CCC>CCT	p.P1139P	PALM2-AKAP2_uc004bek.3_Silent_p.P907P|PALM2-AKAP2_uc004bej.3_Silent_p.P907P|PALM2-AKAP2_uc004bel.1_Silent_p.P717P|AKAP2_uc011lwi.1_Silent_p.P765P|AKAP2_uc004bem.2_Silent_p.P765P|PALM2-AKAP2_uc010mtw.1_Silent_p.P725P|AKAP2_uc011lwj.1_Silent_p.P676P|PALM2-AKAP2_uc004ben.2_Silent_p.P676P	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	676							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						AGACCAGGCCCGAAGGAAGCT	0.602000													13	19					0	0	1	0	0	
SVEP1	79987	broad.mit.edu	37	9	113341715	113341715	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:113341715C>T	uc010mtz.2	-	1	446	c.109G>A	c.(109-111)GAG>AAG	p.E37K	SVEP1_uc010mua.1_Missense_Mutation_p.E37K|SVEP1_uc004beu.2_Missense_Mutation_p.E37K|uc004bew.1_RNA	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	37					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						GGCGCGGTCTCGGGGAAGAGG	0.716000													3	10					0	0	1	0	0	
C9orf84	158401	broad.mit.edu	37	9	114490105	114490105	+	Missense_Mutation	SNP	C	T	T	rs41316510	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:114490105C>T	uc004bfr.2	-	11	1585	c.1450G>A	c.(1450-1452)GAT>AAT	p.D484N	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.D445N|C9orf84_uc010mug.2_Missense_Mutation_p.D430N	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	484										ovary(2)	2						TCAAAGTGATCGTTATTTTCT	0.328000													40	62					0	0	1	0	0	
SUSD1	64420	broad.mit.edu	37	9	114886564	114886564	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:114886564A>G	uc004bfu.2	-	6	900	c.859T>C	c.(859-861)TGG>CGG	p.W287R	SUSD1_uc010mui.2_Missense_Mutation_p.W287R|SUSD1_uc010muj.2_Missense_Mutation_p.W287R	NM_022486	NP_071931	Q6UWL2	SUSD1_HUMAN	sushi domain containing 1 precursor	287	Sushi 2.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						CTTTCTCTCCAGGTGCCTTTC	0.527000													58	105					0	0	1	0	0	
HDHD3	81932	broad.mit.edu	37	9	116136613	116136613	+	Nonsense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:116136613G>A	uc004bhi.1	-	2	806	c.22C>T	c.(22-24)CGA>TGA	p.R8*	HDHD3_uc004bhj.2_Nonsense_Mutation_p.R8*|HDHD3_uc004bhk.2_Nonsense_Mutation_p.R8*	NM_031219	NP_112496	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain	8							phosphoglycolate phosphatase activity|protein binding				0						GTCAGCAGTCGTATCTGCAGC	0.652000													10	10					0	0	1	0	0	
ALAD	210	broad.mit.edu	37	9	116152751	116152751	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:116152751C>T	uc011lxf.1	-	7	706	c.504G>A	c.(502-504)TCG>TCA	p.S168S	ALAD_uc011lxe.1_Silent_p.S151S|ALAD_uc004bhl.3_Silent_p.S197S	NM_000031	NP_000022	P13716	HEM2_HUMAN	delta-aminolevulinic acid dehydratase	168					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding				0					Aminolevulinic acid(DB00855)	CCATCATGTCCGACGGGGCTA	0.627000													14	31					0	0	1	0	0	
ZNF618	114991	broad.mit.edu	37	9	116770651	116770651	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:116770651A>G	uc004bid.2	+	8	767	c.668A>G	c.(667-669)AAC>AGC	p.N223S	ZNF618_uc004bib.1_Missense_Mutation_p.N191S|ZNF618_uc004bic.2_Missense_Mutation_p.N191S|ZNF618_uc011lxi.1_Missense_Mutation_p.N191S|ZNF618_uc011lxj.1_Missense_Mutation_p.N191S	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GCCCCTGAGAACCGGGCAGGT	0.637000													24	29					0	0	1	0	0	
ZNF618	114991	broad.mit.edu	37	9	116811914	116811914	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:116811914G>A	uc004bid.2	+	15	2431	c.2332G>A	c.(2332-2334)GCA>ACA	p.A778T	ZNF618_uc004bic.2_Missense_Mutation_p.A685T|ZNF618_uc011lxi.1_Missense_Mutation_p.A745T|ZNF618_uc011lxj.1_Missense_Mutation_p.A746T|ZNF618_uc010mvb.2_Missense_Mutation_p.A368T	NM_133374	NP_588615	Q5T7W0	ZN618_HUMAN	zinc finger protein 618	778					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCCAACGACGCAGGCACTGT	0.632000													29	48					0	0	1	0	0	
COL27A1	85301	broad.mit.edu	37	9	116930508	116930508	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:116930508G>A	uc011lxl.1	+	3	673	c.673G>A	c.(673-675)GCT>ACT	p.A225T	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.A75T	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	225	Laminin G-like.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GACGCAGGTCGCTCACAATTA	0.562000													21	49					0	0	1	0	0	
COL27A1	85301	broad.mit.edu	37	9	117068923	117068923	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:117068923C>T	uc011lxl.1	+	58	5062	c.5062C>T	c.(5062-5064)CGG>TGG	p.R1688W	COL27A1_uc004bii.2_RNA|COL27A1_uc011lxn.1_5'Flank	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	1688	Fibrillar collagen NC1.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						GAACCCCGCCCGGGTCTGCAG	0.612000											OREG0019417	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	30					0	0	1	0	0	
CDK5RAP2	55755	broad.mit.edu	37	9	123199642	123199642	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:123199642C>T	uc004bkf.2	-	25	4067	c.3886G>A	c.(3886-3888)GAG>AAG	p.E1296K	CDK5RAP2_uc010mvi.2_Missense_Mutation_p.E305K|CDK5RAP2_uc004bke.2_Missense_Mutation_p.E581K|CDK5RAP2_uc004bkg.2_Missense_Mutation_p.E1296K|CDK5RAP2_uc011lxw.1_Missense_Mutation_p.E561K|CDK5RAP2_uc011lxx.1_RNA|CDK5RAP2_uc011lxy.1_RNA|CDK5RAP2_uc011lxz.1_Missense_Mutation_p.E561K|CDK5RAP2_uc011lya.1_Missense_Mutation_p.E561K|CDK5RAP2_uc004bkh.1_Missense_Mutation_p.E1066K|CDK5RAP2_uc004bki.2_Missense_Mutation_p.E1063K	NM_018249	NP_060719	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1296					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			ovary(2)|lung(1)|skin(1)	4						TGGAAACCCTCGGCCACACAG	0.493000													13	28					0	0	1	0	0	
DAB2IP	153090	broad.mit.edu	37	9	124461682	124461682	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:124461682C>T	uc004bln.2	+	3	292	c.223C>T	c.(223-225)CGC>TGC	p.R75C		NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	103	PH.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity	p.R75*(1)		ovary(1)|central_nervous_system(1)	2						CCACAGCTTCCGCCACATCCT	0.453000													7	12					0	0	1	0	0	
OR1N1	138883	broad.mit.edu	37	9	125289508	125289508	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:125289508T>G	uc004bmn.1	-	1	65	c.65A>C	c.(64-66)CAG>CCG	p.Q22P		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						GAGGGACTGCTGTTGCTCTGG	0.502000													14	29					0	0	1	0	0	
MAPKAP1	79109	broad.mit.edu	37	9	128206809	128206809	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:128206809C>T	uc004bpv.2	-	11	1747	c.1414G>A	c.(1414-1416)GCT>ACT	p.A472T	MAPKAP1_uc011lzt.1_Missense_Mutation_p.A275T|MAPKAP1_uc010mwz.2_RNA|MAPKAP1_uc011lzu.1_Missense_Mutation_p.A275T|MAPKAP1_uc011lzv.1_Missense_Mutation_p.A180T|MAPKAP1_uc004bpw.2_Missense_Mutation_p.A280T|MAPKAP1_uc004bpx.2_Missense_Mutation_p.A280T|MAPKAP1_uc004bpy.2_Missense_Mutation_p.A436T|MAPKAP1_uc004bpz.2_Missense_Mutation_p.A425T|MAPKAP1_uc010mxa.2_RNA|MAPKAP1_uc004bpu.2_RNA	NM_001006617	NP_001006618	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated	472	Interaction with ATF2.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			ovary(2)|lung(2)	4						ACGGTAGCAGCGTCCGATTCA	0.468000													35	61					0	0	1	0	0	
ZBTB34	403341	broad.mit.edu	37	9	129642094	129642094	+	Missense_Mutation	SNP	A	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:129642094A>C	uc004bqm.3	+	2	501	c.404A>C	c.(403-405)GAC>GCC	p.D135A		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGAGATGTTGACTCTGTTACC	0.493000													31	62					0	0	1	0	0	
RALGPS1	9649	broad.mit.edu	37	9	129931041	129931041	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:129931041G>A	uc004bqo.1	+	10	1099	c.832G>A	c.(832-834)GAC>AAC	p.D278N	RALGPS1_uc011mab.1_Missense_Mutation_p.D278N|RALGPS1_uc011mac.1_Missense_Mutation_p.D278N|RALGPS1_uc004bqq.3_Missense_Mutation_p.D278N	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	278	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						TGTGGAAGACGACAACTACAA	0.537000													43	73					0	0	1	0	0	
CDK9	1025	broad.mit.edu	37	9	130551706	130551706	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:130551706A>G	uc004bse.2	+	7	1126	c.1003A>G	c.(1003-1005)ATG>GTG	p.M335V		NM_001261	NP_001252	P50750	CDK9_HUMAN	cyclin-dependent kinase 9	335					cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(1)	1						CCTGACGTCCATGTTCGAGTA	0.627000													27	57					0	0	1	0	0	
FAM102A	399665	broad.mit.edu	37	9	130710647	130710647	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:130710647G>A	uc004bsx.1	-	5	540	c.461C>T	c.(460-462)ACG>ATG	p.T154M	FAM102A_uc004bsw.1_Missense_Mutation_p.T12M|FAM102A_uc004bsy.1_5'Flank	NM_001035254	NP_001030331	Q5T9C2	F102A_HUMAN	early estrogen-induced gene 1 protein isoform a	154										ovary(1)	1						CAGCACTCACGTCTTGAAGCA	0.612000													35	40					0	0	1	0	0	
CERCAM	51148	broad.mit.edu	37	9	131198171	131198171	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:131198171G>A	uc004buz.3	+	12	2173	c.1775G>A	c.(1774-1776)CGA>CAA	p.R592Q	CERCAM_uc004buy.1_Missense_Mutation_p.R514Q|CERCAM_uc010mxz.2_Missense_Mutation_p.R514Q	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	592	Prevents secretion from ER (Potential).				cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						CCCCAGCCCCGAGATGAGCTC	0.657000													6	10					0	0	1	0	0	
NUP188	23511	broad.mit.edu	37	9	131731771	131731771	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:131731771C>T	uc004bws.1	+	10	912	c.890C>T	c.(889-891)GCG>GTG	p.A297V		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	297					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						CATCAGTTTGCGCAGGATGGG	0.428000													20	54					0	0	1	0	0	
SH3GLB2	56904	broad.mit.edu	37	9	131771452	131771452	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:131771452C>T	uc004bwv.2	-	10	1159	c.1013G>A	c.(1012-1014)CGC>CAC	p.R338H	SH3GLB2_uc004bww.2_Missense_Mutation_p.R347H|SH3GLB2_uc004bwx.1_Missense_Mutation_p.R338H|SH3GLB2_uc011mbm.1_Missense_Mutation_p.R347H	NM_020145	NP_064530	Q9NR46	SHLB2_HUMAN	SH3-domain GRB2-like endophilin B2	338	SH3.				filopodium assembly|signal transduction	cytoplasm|nucleus	cytoskeletal adaptor activity|SH3 domain binding				0						CCGAGCTTTGCGGGTCCCACT	0.697000													12	11					0	0	1	0	0	
METTL11A	28989	broad.mit.edu	37	9	132396542	132396542	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:132396542G>A	uc004byd.1	+	3	566	c.372G>A	c.(370-372)CCG>CCA	p.P124P	METTL11A_uc010myw.1_Intron|METTL11A_uc011mbs.1_Intron	NM_014064	NP_054783	Q9BV86	NTM1A_HUMAN	methyltransferase like 11A	124					chromosome segregation|N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|spindle organization	nucleus	protein binding|protein methyltransferase activity				0						ACTTCACCCCGGAGCCGGACT	0.587000													37	57					0	0	1	0	0	
TOR1B	27348	broad.mit.edu	37	9	132571734	132571734	+	Missense_Mutation	SNP	C	T	T	rs147733415		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:132571734C>T	uc004byk.1	+	5	943	c.883C>T	c.(883-885)CGT>TGT	p.R295C		NM_014506	NP_055321	O14657	TOR1B_HUMAN	torsin family 1, member B (torsin B) precursor	295					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen	ATP binding|nucleoside-triphosphatase activity|unfolded protein binding				0		Ovarian(14;0.0586)				GATGAGGGCCCGTGGTTCTGC	0.478000													32	47					0	0	1	0	0	
LAMC3	10319	broad.mit.edu	37	9	133914603	133914603	+	Silent	SNP	C	T	T	rs148513856		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:133914603C>T	uc004caa.1	+	6	1349	c.1251C>T	c.(1249-1251)CCC>CCT	p.P417P		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	417	Laminin EGF-like 3.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GCTGTCTGCCCGGGTTCCACT	0.632000													15	24					0	0	1	0	0	
POMT1	10585	broad.mit.edu	37	9	134379721	134379721	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:134379721C>T	uc004cav.2	+	2	318	c.116C>T	c.(115-117)GCT>GTT	p.A39V	POMT1_uc011mci.1_Missense_Mutation_p.A39V|POMT1_uc004cax.2_Missense_Mutation_p.A39V|POMT1_uc011mcj.1_Intron|POMT1_uc004cau.2_Missense_Mutation_p.A39V|POMT1_uc004caw.2_Intron|POMT1_uc011mck.1_Intron|POMT1_uc011mcl.1_Intron|POMT1_uc011mcm.1_Missense_Mutation_p.A39V	NM_007171	NP_009102	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1 isoform a	39					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TACCCGCGGGCTGTGGTGTAA	0.532000											OREG0019563	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	33					0	0	1	0	0	
GTF3C4	9329	broad.mit.edu	37	9	135553865	135553865	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:135553865G>A	uc010mzv.2	+	2	1117	c.859G>A	c.(859-861)GTG>ATG	p.V287M	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	287					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TAATATCGCCGTGTGGCAGTT	0.502000													44	61					0	0	1	0	0	
TSC1	7248	broad.mit.edu	37	9	135786076	135786076	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:135786076C>T	uc004cca.2	-	12	1379	c.1145G>A	c.(1144-1146)GGT>GAT	p.G382D	TSC1_uc004ccb.3_Missense_Mutation_p.G381D|TSC1_uc011mcq.1_Missense_Mutation_p.G331D|TSC1_uc011mcr.1_Intron|TSC1_uc011mcs.1_Missense_Mutation_p.G261D|TSC1_uc004ccc.1_Missense_Mutation_p.G382D	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	382					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		TCCTTTTCCACCTGCTTAGAG	0.463000			D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				51	123					0	0	1	0	0	
SURF6	6838	broad.mit.edu	37	9	136199105	136199105	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:136199105G>A	uc004cdb.3	-	5	764	c.686C>T	c.(685-687)ACG>ATG	p.T229M		NM_006753	NP_006744	O75683	SURF6_HUMAN	surfeit 6	229						granular component	DNA binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		GGTCAGCGGCGTGAGGTTCCC	0.667000													11	69					0	0	1	0	0	
SURF2	6835	broad.mit.edu	37	9	136226922	136226922	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:136226922G>A	uc004cdi.2	+	4	482	c.434G>A	c.(433-435)CGC>CAC	p.R145H		NM_017503	NP_059973	Q15527	SURF2_HUMAN	surfeit 2	145							protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		GACGGGCCTCGCCCGCGGGAA	0.627000													3	21					0	0	1	0	0	
C9orf96	169436	broad.mit.edu	37	9	136266947	136266947	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:136266947C>A	uc004cdk.2	+	13	1340	c.1279C>A	c.(1279-1281)CCC>ACC	p.P427T	C9orf96_uc004cdl.2_Intron	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	427							ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TCAGAGCCACCCCGAGGAGGA	0.627000													13	35					5.50884e-06	5.62949e-06	1	1	0	
SARDH	1757	broad.mit.edu	37	9	136536724	136536724	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:136536724G>A	uc004cep.3	-	18	2393	c.2259C>T	c.(2257-2259)GCC>GCT	p.A753A	SARDH_uc004ceo.2_Silent_p.A753A|SARDH_uc011mdn.1_Silent_p.A753A|SARDH_uc011mdo.1_Silent_p.A585A|SARDH_uc004cen.2_Silent_p.A181A	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	753					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGGCACCCGCGGCCATCACAG	0.662000													3	11					0	0	1	0	0	
WDR5	11091	broad.mit.edu	37	9	137005059	137005059	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:137005059G>A	uc004cey.2	+	2	231	c.60G>A	c.(58-60)TCG>TCA	p.S20S	WDR5_uc004cez.2_Silent_p.S20S	NM_017588	NP_060058	P61964	WDR5_HUMAN	WD repeat domain 5	20					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding				0		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		CAACCCCTTCGTCATCCGCCA	0.622000													28	40					0	0	1	0	0	
COL5A1	1289	broad.mit.edu	37	9	137710579	137710579	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:137710579G>A	uc004cfe.2	+	55	4690	c.4308G>A	c.(4306-4308)CCG>CCA	p.P1436P		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1436	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCCCGGACCGGATGGCCTTC	0.697000													9	14					0	0	1	0	0	
OLFM1	10439	broad.mit.edu	37	9	137998693	137998693	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:137998693G>A	uc010nar.2	+	5	1091	c.775G>A	c.(775-777)GAT>AAT	p.D259N	OLFM1_uc004cfl.3_Missense_Mutation_p.D241N|OLFM1_uc004cfn.3_Missense_Mutation_p.D10N	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	259	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		CCCTGAAGGCGATAACCGGGT	0.617000													3	8					0	0	1	0	0	
MRPS2	51116	broad.mit.edu	37	9	138395646	138395646	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:138395646G>A	uc004cfv.3	+	4	632	c.558G>A	c.(556-558)ACG>ACA	p.T186T	MRPS2_uc004cfw.3_Silent_p.T96T|MRPS2_uc004cfx.3_Silent_p.T101T|MRPS2_uc010nat.2_Silent_p.T167T|uc004cfy.2_Intron	NM_016034	NP_057118	Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	186					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome				0				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		TTGGCCCCACGGTCCGCCTGC	0.607000													20	35					0	0	1	0	0	
CARD9	64170	broad.mit.edu	37	9	139264798	139264798	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139264798G>A	uc004chg.3	-	6	1065	c.899C>T	c.(898-900)ACC>ATC	p.T300I	CARD9_uc011mdw.1_Missense_Mutation_p.T300I|CARD9_uc011mdx.1_Missense_Mutation_p.T196I	NM_052813	NP_434700	Q9H257	CARD9_HUMAN	caspase recruitment domain protein 9 isoform 1	300					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			pancreas(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		GGAGAAGATGGTGTTGGCCTG	0.697000													3	11					0	0	1	0	0	
SEC16A	9919	broad.mit.edu	37	9	139370620	139370620	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139370620G>A	uc004chx.2	-	3	1757	c.1448C>T	c.(1447-1449)CCG>CTG	p.P483L	SEC16A_uc004chv.3_Missense_Mutation_p.P110L|SEC16A_uc004chw.2_Missense_Mutation_p.P483L|SEC16A_uc010nbn.2_Missense_Mutation_p.P483L|SEC16A_uc010nbo.1_Missense_Mutation_p.P483L	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	305					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CTGGTCACTCGGGGAGGAAGG	0.552000													25	27					0	0	1	0	0	
C9orf86	55684	broad.mit.edu	37	9	139733726	139733726	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139733726G>A	uc004cji.1	+	12	1814	c.1546G>A	c.(1546-1548)GCA>ACA	p.A516T	C9orf86_uc004cjj.1_Missense_Mutation_p.A517T|C9orf86_uc004cjk.1_Intron|C9orf86_uc010nbr.1_Intron|C9orf86_uc004cjl.1_Intron|C9orf86_uc010nbs.1_Missense_Mutation_p.A401T|C9orf86_uc004cjn.1_Missense_Mutation_p.A310T	NM_024718	NP_078994	Q3YEC7	PARF_HUMAN	Rab-like GTP-binding protein 1 isoform 1	516					small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		CACGAGGACCGCAGCACCCCC	0.662000													7	6					0	0	1	0	0	
ABCA2	20	broad.mit.edu	37	9	139905490	139905490	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139905490C>T	uc011mem.1	-	38	6136	c.5988G>A	c.(5986-5988)GCG>GCA	p.A1996A	ABCA2_uc011mel.1_Silent_p.A1997A|ABCA2_uc004ckl.1_Silent_p.A1927A|ABCA2_uc004ckm.1_Silent_p.A2027A	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1996	Helical; (Potential).				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CGCCCTCAACCGCCATGGCCA	0.537000													13	25					0	0	1	0	0	
ABCA2	20	broad.mit.edu	37	9	139907184	139907184	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139907184G>A	uc011mem.1	-	30	5206	c.5058C>T	c.(5056-5058)TCC>TCT	p.S1686S	ABCA2_uc011mel.1_Silent_p.S1687S|ABCA2_uc004ckl.1_Silent_p.S1617S|ABCA2_uc004ckm.1_Silent_p.S1717S|ABCA2_uc004ckn.1_RNA	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	1686					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGAAGCGGTCGGAGGTGAAGA	0.662000													26	35					0	0	1	0	0	
FUT7	2529	broad.mit.edu	37	9	139925737	139925737	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139925737G>A	uc004ckq.2	-	2	1303	c.454C>T	c.(454-456)CCC>TCC	p.P152S	ABCA2_uc011mel.1_5'Flank|ABCA2_uc011mem.1_5'Flank|ABCA2_uc004ckl.1_5'Flank|ABCA2_uc004ckm.1_5'Flank|C9orf139_uc004ckp.1_Intron	NM_004479	NP_004470	Q11130	FUT7_HUMAN	fucosyltransferase 7	152	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.96e-05)|Epithelial(140;0.000486)		CGGCCATAGGGCACAAAGATG	0.677000													4	9					0	0	1	0	0	
C9orf139	401563	broad.mit.edu	37	9	139929339	139929339	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139929339G>T	uc004ckp.1	+	3	1920	c.406G>T	c.(406-408)GGG>TGG	p.G136W	FUT7_uc004ckq.2_5'Flank	NM_207511	NP_997394	Q6ZV77	CI139_HUMAN	hypothetical protein LOC401563	136											0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		TGGCTGCCATGGGGCCCAATC	0.632000													31	48					3.6622e-26	3.95502e-26	1	1	0	
C9orf139	401563	broad.mit.edu	37	9	139929343	139929343	+	Missense_Mutation	SNP	C	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:139929343C>G	uc004ckp.1	+	3	1924	c.410C>G	c.(409-411)GCC>GGC	p.A137G	FUT7_uc004ckq.2_5'Flank	NM_207511	NP_997394	Q6ZV77	CI139_HUMAN	hypothetical protein LOC401563	137											0	all_cancers(76;0.0893)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.99e-05)|Epithelial(140;0.000493)		TGCCATGGGGCCCAATCGTGC	0.627000													32	51					0	0	1	0	0	
NOXA1	10811	broad.mit.edu	37	9	140327956	140327956	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:140327956G>A	uc004cmv.2	+	11	1096	c.961G>A	c.(961-963)GCC>ACC	p.A321T	C9orf167_uc011mew.1_Intron|NOXA1_uc004cmu.2_Missense_Mutation_p.A321T|NOXA1_uc010nch.2_Missense_Mutation_p.A265T	NM_006647	NP_006638	Q86UR1	NOXA1_HUMAN	NADPH oxidase activator 1	321	OPR.		Missing (in NOXA1truncated, a cDNA isolated from Caco-2 cells treated with butyrate).		regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|superoxide metabolic process	cytoplasm|NADPH oxidase complex	Rac GTPase binding|superoxide-generating NADPH oxidase activator activity				0	all_cancers(76;0.0926)			OV - Ovarian serous cystadenocarcinoma(145;0.000238)|Epithelial(140;0.000982)		CGTGCAGTGCGCCTTCACAGT	0.706000													5	7					0	0	1	0	0	
CACNA1B	774	broad.mit.edu	37	9	140777198	140777198	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:140777198C>T	uc004cog.2	+	3	538	c.393C>T	c.(391-393)GAC>GAT	p.D131D	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	131	I.|Extracellular (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCTCCTAGGACGACACGGAGC	0.592000													22	41					0	0	1	0	0	
PPP2R3B	28227	broad.mit.edu	37	X	306252	306252	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:306252G>A	uc004cpg.2	-	7	1236	c.1035C>T	c.(1033-1035)CAC>CAT	p.H345H	PPP2R3B_uc011mha.1_Silent_p.H184H	NM_013239	NP_037371	Q9Y5P8	P2R3B_HUMAN	protein phosphatase 2, regulatory subunit B'',	345					cell cycle arrest|protein dephosphorylation	nucleus|protein phosphatase type 2A complex	calcium ion binding|protein phosphatase type 2A regulator activity|protein serine/threonine phosphatase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCCACGCACCGTGGTCATTGT	0.667000													17	20					0	0	1	0	0	
SHOX	6473	broad.mit.edu	37	X	601806	601806	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:601806G>A	uc004cph.1	+	5	1308	c.617G>A	c.(616-618)CGG>CAG	p.R206Q	SHOX_uc004cpi.2_Missense_Mutation_p.R206Q	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	206					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGAGCCTTACGGATGCCTTTC	0.567000													35	31					0	0	1	0	0	
ARSF	416	broad.mit.edu	37	X	3002316	3002316	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:3002316C>T	uc004cre.1	+	6	660	c.439C>T	c.(439-441)CGA>TGA	p.R147*	ARSF_uc004crf.1_Nonsense_Mutation_p.R147*	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	147						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTGCGACTCCCGAAGTGACCA	0.478000													34	64					0	0	1	0	0	
MXRA5	25878	broad.mit.edu	37	X	3235295	3235295	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:3235295C>T	uc004crg.3	-	6	6584	c.6427G>A	c.(6427-6429)GCA>ACA	p.A2143T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2143						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCGTTGGCTGCTGCACGCTGC	0.711000													10	20					0	0	1	0	0	
MXRA5	25878	broad.mit.edu	37	X	3240108	3240108	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:3240108C>T	uc004crg.3	-	5	3775	c.3618G>A	c.(3616-3618)GTG>GTA	p.V1206V		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1206						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGTGTTATCCACCCAAGCTG	0.458000													30	64					0	0	1	0	0	
NLGN4X	57502	broad.mit.edu	37	X	5821129	5821129	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:5821129G>A	uc010ndh.2	-	5	2091	c.1590C>T	c.(1588-1590)TTC>TTT	p.F530F	NLGN4X_uc004crp.2_Silent_p.F550F|NLGN4X_uc004crq.2_Silent_p.F530F|NLGN4X_uc010ndi.2_Silent_p.F567F|NLGN4X_uc004crr.2_Silent_p.F530F|NLGN4X_uc010ndj.2_Silent_p.F530F	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	530	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						CAGTTTTGGCGAAGTTCGTCC	0.512000													34	42					0	0	1	0	0	
STS	412	broad.mit.edu	37	X	7267953	7267953	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:7267953T>C	uc004cry.3	+	10	1648	c.1403T>C	c.(1402-1404)TTC>TCC	p.F468S		NM_000351	NP_000342	P08842	STS_HUMAN	steryl-sulfatase precursor	468	Lumenal.				female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			central_nervous_system(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	AAGGCCTTTTTCTTCACCCCC	0.483000									Ichthyosis				11	185					0	0	1	0	0	
SHROOM2	357	broad.mit.edu	37	X	9900722	9900722	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:9900722G>A	uc004csu.1	+	6	3489	c.3399G>A	c.(3397-3399)GAG>GAA	p.E1133E	SHROOM2_uc004csv.2_5'UTR|SHROOM2_uc011mic.1_5'UTR|SHROOM2_uc004csw.1_5'UTR	NM_001649	NP_001640	Q13796	SHRM2_HUMAN	apical protein of Xenopus-like	1133					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8		Hepatocellular(5;0.000888)				CTGTCTGTGAGCGTGGAAGCC	0.657000													28	42					0	0	1	0	0	
WWC3	55841	broad.mit.edu	37	X	10094192	10094192	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:10094192C>T	uc004csx.3	+	15	2150	c.1952C>T	c.(1951-1953)ACG>ATG	p.T651M	WWC3_uc010nds.2_Missense_Mutation_p.T315M|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	651	C2.									ovary(4)	4						GACTCGGGCACGCCCAACACT	0.597000													128	223					0	0	1	0	0	
TMSL3	7117	broad.mit.edu	37	X	12994449	12994449	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:12994449G>A	uc004cvf.2	+	2	147	c.69G>A	c.(67-69)ACG>ACA	p.T23T		NM_021109	NP_066932			thymosin, beta 4												0		all_cancers(2;6.48e-24)|all_epithelial(2;3.86e-25)|Colorectal(2;8.52e-12)|all_lung(2;3.73e-07)|Lung NSC(2;7.99e-07)|Renal(2;0.0243)|Hepatocellular(203;0.0411)		Epithelial(2;5.28e-11)|OV - Ovarian serous cystadenocarcinoma(123;8.9e-10)|all cancers(2;3.21e-09)|STAD - Stomach adenocarcinoma(1;0.0201)		AGACAGAGACGCAAGAGAAAA	0.547000													39	53					0	0	1	0	0	
TXLNG	55787	broad.mit.edu	37	X	16859880	16859880	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:16859880G>A	uc004cxq.1	+	10	1629	c.1578G>A	c.(1576-1578)TCG>TCA	p.S526S	TXLNG_uc010ney.1_Silent_p.S394S	NM_018360	NP_060830	Q9NUQ3	TXLNG_HUMAN	gamma-taxilin	526					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane				lung(1)	1						CCATCGAGTCGGTTGACTAAG	0.478000													61	79					0	0	1	0	0	
RBBP7	5931	broad.mit.edu	37	X	16870926	16870926	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:16870926G>A	uc004cxt.2	-	7	1189	c.831C>T	c.(829-831)TGC>TGT	p.C277C	RBBP7_uc004cxs.1_Silent_p.C321C|RBBP7_uc004cxu.2_Silent_p.C268C|RBBP7_uc010nez.2_3'UTR	NM_002893	NP_002884	Q16576	RBBP7_HUMAN	retinoblastoma binding protein 7	277	WD 5.				cell proliferation|cellular heat acclimation|CenH3-containing nucleosome assembly at centromere|DNA replication|multicellular organismal development|negative regulation of cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex|NuRD complex	protein binding			upper_aerodigestive_tract(1)|ovary(1)	2	Hepatocellular(33;0.0997)					TGAATGAGAGGCAGTTGACTT	0.478000													83	115					0	0	1	0	0	
ZNF645	158506	broad.mit.edu	37	X	22291518	22291518	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:22291518G>A	uc004dai.1	+	1	459	c.410G>A	c.(409-411)CGC>CAC	p.R137H		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	137	C2H2-type.					intracellular	zinc ion binding			lung(1)|pancreas(1)	2						ATCAAACGCCGCCATAAGAGA	0.443000													36	58					0	0	1	0	0	
POLA1	5422	broad.mit.edu	37	X	24750565	24750565	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:24750565T>C	uc004dbl.2	+	16	1770	c.1747T>C	c.(1747-1749)TTC>CTC	p.F583L	POLA1_uc004dbn.2_Missense_Mutation_p.F447L	NM_016937	NP_058633	P09884	DPOLA_HUMAN	DNA-directed DNA polymerase alpha 1	583					cell proliferation|DNA replication checkpoint|DNA replication, synthesis of RNA primer|DNA-dependent DNA replication initiation|double-strand break repair via nonhomologous end joining|interspecies interaction between organisms|lagging strand elongation|leading strand elongation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|cytoplasm|nuclear envelope|nuclear matrix|nucleolus|nucleoplasm	chromatin binding|DNA-directed DNA polymerase activity|metal ion binding|nucleoside binding			ovary(2)|skin(1)	3					Clofarabine(DB00631)|Fludarabine(DB01073)	TCAGTCACACTTCTGTGGTAT	0.368000													19	30					0	0	1	0	0	
IL1RAPL1	11141	broad.mit.edu	37	X	29973787	29973787	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:29973787T>C	uc004dby.2	+	11	2449	c.1941T>C	c.(1939-1941)CAT>CAC	p.H647H		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	647	Cytoplasmic (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GCAATCAGCATACCTACTGTA	0.517000													16	27					0	0	1	0	0	
TAB3	257397	broad.mit.edu	37	X	30870981	30870981	+	Missense_Mutation	SNP	G	A	A	rs147799245		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:30870981G>A	uc004dcj.2	-	7	2287	c.1624C>T	c.(1624-1626)CGG>TGG	p.R542W	TAB3_uc004dck.2_Missense_Mutation_p.R542W|TAB3_uc010ngl.2_Missense_Mutation_p.R542W	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	542	Potential.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						GACTTCAACCGCTCTAGCTCC	0.463000													24	49					0	0	1	0	0	
CXorf22	170063	broad.mit.edu	37	X	35989784	35989784	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:35989784G>A	uc004ddj.2	+	12	2111	c.2052G>A	c.(2050-2052)GCG>GCA	p.A684A	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	684										large_intestine(1)|lung(1)|ovary(1)	3						TCTCAGAAGCGGAAATAGAAG	0.418000													20	25					0	0	1	0	0	
FAM47C	442444	broad.mit.edu	37	X	37027114	37027114	+	Missense_Mutation	SNP	C	T	T	rs143691874		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:37027114C>T	uc004ddl.1	+	1	645	c.631C>T	c.(631-633)CGC>TGC	p.R211C		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	211										ovary(3)	3						GTCCAGTCTCCGCCCGGAGCC	0.647000													25	36					0	0	1	0	0	
FAM47C	442444	broad.mit.edu	37	X	37027775	37027775	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:37027775C>T	uc004ddl.1	+	1	1306	c.1292C>T	c.(1291-1293)CCC>CTC	p.P431L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	431										ovary(3)	3						CTGGAGCCTCCCAAGACTCGC	0.612000													33	71					0	0	1	0	0	
USP9X	8239	broad.mit.edu	37	X	41025387	41025387	+	Nonsense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:41025387C>T	uc004dfb.2	+	16	2881	c.2248C>T	c.(2248-2250)CGA>TGA	p.R750*	USP9X_uc004dfc.2_Nonsense_Mutation_p.R750*	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	750					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						TGTGAATTGTCGAGAAGGAAA	0.373000													21	50					0	0	1	0	0	
USP9X	8239	broad.mit.edu	37	X	41075795	41075795	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:41075795G>A	uc004dfb.2	+	35	6608	c.5975G>A	c.(5974-5976)CGG>CAG	p.R1992Q	USP9X_uc004dfc.2_Missense_Mutation_p.R1992Q	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	1992					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						AGAAGTGTACGGAAACAGAAC	0.368000													44	63					0	0	1	0	0	
NDUFB11	54539	broad.mit.edu	37	X	47003890	47003890	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:47003890G>A	uc004dhd.2	-	1	720	c.189C>T	c.(187-189)GAC>GAT	p.D63D	NDUFB11_uc004dhc.2_Silent_p.D63D|RBM10_uc004dhe.1_5'Flank|RBM10_uc004dhf.2_5'Flank|RBM10_uc004dhg.2_5'Flank|RBM10_uc004dhh.2_5'Flank|RBM10_uc010nhq.2_5'Flank|RBM10_uc004dhi.2_5'Flank	NM_001135998	NP_001129470	Q9NX14	NDUBB_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	63					respiratory electron transport chain|transport	integral to membrane|mitochondrial respiratory chain complex I					0						ACAAGTTTTCGTCCTCGGGTT	0.657000											OREG0019755	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	20					0	0	1	0	0	
GLOD5	392465	broad.mit.edu	37	X	48629416	48629416	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:48629416A>G	uc011mmh.1	+	3	316	c.275A>G	c.(274-276)AAA>AGA	p.K92R		NM_001080489	NP_001073958			glyoxalase domain containing 5												0						TTTGAACCCAAAGCCGCTCAC	0.512000													8	15					0	0	1	0	0	
GATA1	2623	broad.mit.edu	37	X	48649621	48649621	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:48649621C>A	uc004dkq.3	+	2	196	c.105C>A	c.(103-105)CCC>CCA	p.P35P		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	35					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.M1fs(7)|p.F34fs*3(2)|p.P35fs*4(2)|p.F33fs*23(1)|p.F33fs*90(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						TTTTCTTCCCCTCTGGGCCTG	0.647000			Mis|F		megakaryoblastic leukemia of Downs Syndrome								5	10					1.23904e-05	1.26366e-05	1	1	0	
HDAC6	10013	broad.mit.edu	37	X	48678589	48678589	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:48678589C>T	uc011mmi.1	+	23	2359	c.2264C>T	c.(2263-2265)TCA>TTA	p.S755L	HDAC6_uc004dks.1_Missense_Mutation_p.S755L|HDAC6_uc010nig.1_Missense_Mutation_p.S603L|HDAC6_uc004dkt.1_Missense_Mutation_p.S755L|HDAC6_uc011mmk.1_Missense_Mutation_p.S736L|HDAC6_uc004dkv.1_Missense_Mutation_p.S403L|HDAC6_uc004dkw.1_Missense_Mutation_p.S403L|HDAC6_uc004dkx.1_Missense_Mutation_p.S118L	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	755	Histone deacetylase 2.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	TGCCAGGTGTCACCTGAGGGT	0.577000													35	39					0	0	1	0	0	
TFE3	7030	broad.mit.edu	37	X	48891050	48891050	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:48891050G>A	uc004dmb.3	-	8	1304	c.1066C>T	c.(1066-1068)CGT>TGT	p.R356C	TFE3_uc004dmc.3_Missense_Mutation_p.R251C|TFE3_uc004dme.1_RNA	NM_006521	NP_006512	P19532	TFE3_HUMAN	transcription factor E3	356	Basic motif.				humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		ASPSCR1/TFE3(161)|PRCC/TFE3(25)|SFPQ/TFE3(6)|NONO/TFE3(2)|CLTC/TFE3(2)	soft_tissue(120)|kidney(76)|central_nervous_system(1)	197						CGCCTGCGACGCTCAACTTTG	0.527000			T	SFPQ|ASPSCR1|PRCC|NONO|CLTC	papillary renal|alveolar soft part sarcoma|renal								29	22					0	0	1	0	0	
CCDC120	90060	broad.mit.edu	37	X	48925127	48925127	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:48925127G>A	uc010nik.2	+	10	1879	c.1372G>A	c.(1372-1374)GGT>AGT	p.G458S	CCDC120_uc011mmq.1_Missense_Mutation_p.G446S|CCDC120_uc004dmf.2_Missense_Mutation_p.G458S|CCDC120_uc010nil.2_Missense_Mutation_p.G458S|CCDC120_uc011mmr.1_Missense_Mutation_p.G458S|CCDC120_uc011mms.1_Missense_Mutation_p.G446S	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	458	Pro-rich.						protein binding			pancreas(1)	1						CCGCAGTGGCGGTGGAACAGG	0.706000													18	20					0	0	1	0	0	
GPKOW	27238	broad.mit.edu	37	X	48973476	48973476	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:48973476C>T	uc004dmr.2	-	6	828	c.821G>A	c.(820-822)CGT>CAT	p.R274H		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	274						nucleus	nucleic acid binding			ovary(2)	2						CACAGCCAGACGAACCATGGC	0.547000													25	35					0	0	1	0	0	
MAGIX	79917	broad.mit.edu	37	X	49021225	49021225	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:49021225G>A	uc010nin.1	+	4	351	c.304G>A	c.(304-306)GCA>ACA	p.A102T	MAGIX_uc010nio.1_Intron|MAGIX_uc004dmt.2_Intron|MAGIX_uc004dmu.2_Missense_Mutation_p.A43T|MAGIX_uc004dmw.2_Intron	NM_024859	NP_079135	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked isoform a	102											0						GACATGTAACGCACCTCCCCA	0.537000													64	107					0	0	1	0	0	
CACNA1F	778	broad.mit.edu	37	X	49078999	49078999	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:49078999G>A	uc004dnb.2	-	17	2365	c.2303C>T	c.(2302-2304)ACT>ATT	p.T768I	CACNA1F_uc010nip.2_Missense_Mutation_p.T757I	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	768	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	GTCCTTGGCAGTGCCTGCATC	0.572000													10	38					0	0	1	0	0	
CACNA1F	778	broad.mit.edu	37	X	49079419	49079419	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:49079419G>A	uc004dnb.2	-	15	2149	c.2087C>T	c.(2086-2088)ACG>ATG	p.T696M	CACNA1F_uc010nip.2_Missense_Mutation_p.T685M	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	696	Extracellular (Potential).|II.				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CTGGGGGAACGTGTCAAAGGT	0.567000													5	14					0	0	1	0	0	
CCNB3	85417	broad.mit.edu	37	X	50052149	50052149	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:50052149T>C	uc004dox.3	+	6	1278	c.980T>C	c.(979-981)TTC>TCC	p.F327S	CCNB3_uc004doy.2_Missense_Mutation_p.F327S|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	327					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GAGACACTTTTCCAAGAGCTA	0.443000													80	115					0	0	1	0	0	
CCNB3	85417	broad.mit.edu	37	X	50090755	50090755	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:50090755T>C	uc004dox.3	+	11	4239	c.3941T>C	c.(3940-3942)ATG>ACG	p.M1314T	CCNB3_uc004doy.2_Missense_Mutation_p.M1314T|CCNB3_uc004doz.2_Missense_Mutation_p.M210T|CCNB3_uc010njq.2_Missense_Mutation_p.M206T|CCNB3_uc004dpa.2_Missense_Mutation_p.M153T	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1314					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GCCCTCTACATGAAGAAGCTC	0.498000													12	27					0	0	1	0	0	
IQSEC2	23096	broad.mit.edu	37	X	53279669	53279669	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:53279669C>T	uc004dsd.2	-	5	2290	c.2089G>A	c.(2089-2091)GAG>AAG	p.E697K	IQSEC2_uc004dsc.2_Missense_Mutation_p.E492K	NM_001111125	NP_001104595	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2 isoform1	687					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			ovary(3)	3						TCAAGGCTCTCGTTATCTCCA	0.582000													27	42					0	0	1	0	0	
HUWE1	10075	broad.mit.edu	37	X	53657955	53657955	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:53657955T>C	uc004dsp.2	-	12	1196	c.794A>G	c.(793-795)CAT>CGT	p.H265R		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	265					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGAAAAGCCATGGGCCAGTCG	0.378000													36	60					0	0	1	0	0	
TRO	7216	broad.mit.edu	37	X	54949891	54949891	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:54949891G>A	uc004dtq.2	+	3	1033	c.926G>A	c.(925-927)GGC>GAC	p.G309D	TRO_uc011moj.1_Missense_Mutation_p.G252D|TRO_uc004dts.2_Missense_Mutation_p.G309D|TRO_uc004dtr.2_Missense_Mutation_p.G309D|TRO_uc004dtt.2_RNA|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Intron|TRO_uc004dtw.2_Intron|TRO_uc004dtx.2_5'Flank	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	309					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GCCAGCAGGGGCCCAAATTCT	0.562000													7	6					0	0	1	0	0	
MAGEH1	28986	broad.mit.edu	37	X	55478849	55478849	+	Silent	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:55478849A>G	uc004dum.2	+	1	312	c.42A>G	c.(40-42)AGA>AGG	p.R14R		NM_014061	NP_054780	Q9H213	MAGH1_HUMAN	melanoma antigen, family H, 1 protein	14	MAGE.				apoptosis					ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GTAATGCGAGAGCCGCAGAAG	0.602000													7	10					0	0	1	0	0	
MTMR8	55613	broad.mit.edu	37	X	63444306	63444306	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:63444306C>T	uc011mou.1	-	11	2059	c.1991G>A	c.(1990-1992)CGC>CAC	p.R664H	ASB12_uc004dvp.1_Missense_Mutation_p.R280H|ASB12_uc004dvq.1_Missense_Mutation_p.R289H|ASB12_uc004dvr.1_Missense_Mutation_p.R289H	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						CAAGGCTCTGCGGACGACTAA	0.488000													13	39					0	0	1	0	0	
ZC3H12B	340554	broad.mit.edu	37	X	64722913	64722913	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:64722913A>G	uc010nko.2	+	5	2311	c.2302A>G	c.(2302-2304)ATG>GTG	p.M768V		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	768							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						TTGGGTTGGAATGTGCAATGA	0.473000													36	50					0	0	1	0	0	
MSN	4478	broad.mit.edu	37	X	64949377	64949377	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:64949377C>T	uc004dwf.2	+	4	468	c.270C>T	c.(268-270)TCC>TCT	p.S90S		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	90	FERM.				leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						AGGATGTGTCCGAGGAATTGA	0.517000			T	ALK	ALCL								38	65					0	0	1	0	0	
DLG3	1741	broad.mit.edu	37	X	69669611	69669611	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:69669611C>T	uc004dyi.1	+	4	933	c.605C>T	c.(604-606)GCG>GTG	p.A202V	DLG3_uc004dyj.1_5'Flank	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	202	PDZ 1.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					GCGGTGGAGGCGCTGAAGGAG	0.637000													11	20					0	0	1	0	0	
NLGN3	54413	broad.mit.edu	37	X	70384062	70384062	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:70384062G>A	uc004dzd.1	+	5	997	c.797G>A	c.(796-798)CGC>CAC	p.R266H	NLGN3_uc010nlb.1_Missense_Mutation_p.R226H|NLGN3_uc004dzb.2_Missense_Mutation_p.R246H|NLGN3_uc004dzc.2_Missense_Mutation_p.R129H|NLGN3_uc011mps.1_Missense_Mutation_p.R226H|NLGN3_uc004dze.2_Missense_Mutation_p.R64H|NLGN3_uc011mpr.1_Missense_Mutation_p.R226H	NM_018977	NP_061850	Q9NZ94	NLGN3_HUMAN	neuroligin 3	266	Extracellular (Potential).				neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			ovary(1)	1	Renal(35;0.156)					CAGGCCCTCCGCTGGGTGAGC	0.572000													5	55					0	0	1	0	0	
RGAG4	340526	broad.mit.edu	37	X	71349920	71349920	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:71349920C>T	uc010nlh.1	-	1	1832	c.1471G>A	c.(1471-1473)GAA>AAA	p.E491K	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	491										ovary(2)|skin(1)	3	Renal(35;0.156)					AGGAAGTTTTCGGCGTGGTAA	0.547000													6	51					0	0	1	0	0	
KIAA2022	340533	broad.mit.edu	37	X	73963005	73963005	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:73963005T>C	uc004eby.2	-	3	2004	c.1387A>G	c.(1387-1389)ATG>GTG	p.M463V		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	463					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TCCCGAGCCATATAGCGACTA	0.448000													17	35					0	0	1	0	0	
MAGT1	84061	broad.mit.edu	37	X	77112909	77112909	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:77112909C>T	uc004fof.2	-	4	634	c.572G>A	c.(571-573)CGG>CAG	p.R191Q	MAGT1_uc004fog.3_Intron	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	159					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						TGAAAAACCCCGCACCTGTAA	0.448000													68	126					0	0	1	0	0	
P2RY10	27334	broad.mit.edu	37	X	78216537	78216537	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:78216537G>A	uc004ede.2	+	4	889	c.520G>A	c.(520-522)GAC>AAC	p.D174N	P2RY10_uc004edf.2_Missense_Mutation_p.D174N	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	174	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						GAGAAGCACAGACTTAAACAA	0.498000													37	44					0	0	1	0	0	
ZNF711	7552	broad.mit.edu	37	X	84510642	84510642	+	Missense_Mutation	SNP	G	A	A	rs3747423		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:84510642G>A	uc004eeo.2	+	4	804	c.457G>A	c.(457-459)GAC>AAC	p.D153N	ZNF711_uc004eep.2_Missense_Mutation_p.D153N|ZNF711_uc004eeq.2_Missense_Mutation_p.D153N	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	153					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TTCAGGAGTCGACTCTCCCAC	0.448000													42	67					0	0	1	0	0	
DACH2	117154	broad.mit.edu	37	X	85403798	85403798	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:85403798C>T	uc004eew.2	+	1	344	c.174C>T	c.(172-174)GGC>GGT	p.G58G	DACH2_uc004eex.2_Silent_p.G58G|DACH2_uc010nmq.2_5'UTR	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	58	Poly-Gly.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CCGGAGGCGGCGGCAGGGGCA	0.572000													37	43					0	0	1	0	0	
DIAPH2	1730	broad.mit.edu	37	X	96167391	96167391	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:96167391G>A	uc004efu.3	+	6	1048	c.652G>A	c.(652-654)GAC>AAC	p.D218N	DIAPH2_uc004eft.3_Missense_Mutation_p.D218N|DIAPH2_uc004efs.2_Missense_Mutation_p.D225N	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	218	GBD/FH3.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						AAAGCTTCTGGACAAAAAACA	0.313000													4	12					0	0	1	0	0	
SYTL4	94121	broad.mit.edu	37	X	99934400	99934400	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:99934400C>T	uc004egd.3	-	17	1924	c.1568G>A	c.(1567-1569)GGG>GAG	p.G523E	SYTL4_uc004egc.2_5'Flank|SYTL4_uc010nnb.2_Missense_Mutation_p.G195E|SYTL4_uc010nnc.2_Missense_Mutation_p.G523E|SYTL4_uc004ege.3_Missense_Mutation_p.G523E|SYTL4_uc004egf.3_Missense_Mutation_p.G523E	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	523	C2 2.				exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCCCCCTTCCCCACCTTTACC	0.512000													8	30					0	0	1	0	0	
DRP2	1821	broad.mit.edu	37	X	100492712	100492712	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:100492712T>A	uc004egz.2	+	5	755	c.386T>A	c.(385-387)CTG>CAG	p.L129Q	DRP2_uc011mrh.1_Missense_Mutation_p.L51Q	NM_001939	NP_001930	Q13474	DRP2_HUMAN	dystrophin related protein 2	129	Spectrin 1.				central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			ovary(2)	2						TCAGCTCAGCTGCCCCTACAG	0.552000													9	146					0	0	1	0	0	
ARMCX2	9823	broad.mit.edu	37	X	100911088	100911088	+	Missense_Mutation	SNP	A	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:100911088A>G	uc004eid.2	-	3	1842	c.1487T>C	c.(1486-1488)ATG>ACG	p.M496T	ARMCX2_uc004eie.3_Missense_Mutation_p.M496T|ARMCX2_uc004eif.3_Missense_Mutation_p.M496T|ARMCX2_uc004eig.3_Missense_Mutation_p.M496T|ARMCX2_uc010nnt.2_Missense_Mutation_p.M496T	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	496						integral to membrane	binding			ovary(6)	6						AGTAATAGTCATGTTTGTTAG	0.403000													81	96					0	0	1	0	0	
ARMCX2	9823	broad.mit.edu	37	X	100911473	100911473	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:100911473C>T	uc004eid.2	-	3	1457	c.1102G>A	c.(1102-1104)GTT>ATT	p.V368I	ARMCX2_uc004eie.3_Missense_Mutation_p.V368I|ARMCX2_uc004eif.3_Missense_Mutation_p.V368I|ARMCX2_uc004eig.3_Missense_Mutation_p.V368I|ARMCX2_uc010nnt.2_Missense_Mutation_p.V368I	NM_177949	NP_808818	Q7L311	ARMX2_HUMAN	ALEX2 protein	368						integral to membrane	binding			ovary(6)	6						TGCATGGCAACGGGTCTTCTT	0.552000													37	63					0	0	1	0	0	
TCEAL3	85012	broad.mit.edu	37	X	102864512	102864512	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:102864512G>A	uc004ekq.2	+	3	782	c.520G>A	c.(520-522)GCC>ACC	p.A174T	TCEAL3_uc004ekr.2_Missense_Mutation_p.A174T	NM_001006933	NP_001006934	Q969E4	TCAL3_HUMAN	transcription elongation factor A (SII)-like 3	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GGATCCATTCGCCCCAAGGGG	0.512000													41	220					0	0	1	0	0	
RNF128	79589	broad.mit.edu	37	X	105970199	105970199	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:105970199G>T	uc004eml.2	+	1	306	c.56G>T	c.(55-57)AGA>ATA	p.R19I	RNF128_uc004emk.2_Intron	NM_194463	NP_919445	Q8TEB7	RN128_HUMAN	ring finger protein 128 isoform 1	19						endomembrane system|integral to membrane|perinuclear region of cytoplasm	zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGCTTTTCCAGATTGCTGGCA	0.726000													4	4					0.150653	0.151095	1	1	0	
TSC22D3	1831	broad.mit.edu	37	X	106957756	106957756	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:106957756G>A	uc004eng.2	-	3	648	c.398C>T	c.(397-399)GCG>GTG	p.A133V	TSC22D3_uc004enf.2_Missense_Mutation_p.A76V|TSC22D3_uc004enh.2_Missense_Mutation_p.A199V|TSC22D3_uc004eni.2_Missense_Mutation_p.A199V|TSC22D3_uc004enj.2_Missense_Mutation_p.A199V	NM_004089	NP_004080	Q99576	T22D3_HUMAN	TSC22 domain family, member 3 isoform 2	133							sequence-specific DNA binding transcription factor activity				0						CACTTACACCGCAGAACCACC	0.562000													15	38					0	0	1	0	0	
DCX	1641	broad.mit.edu	37	X	110653323	110653323	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:110653323G>A	uc004epd.2	-	2	719	c.547C>T	c.(547-549)CGT>TGT	p.R183C	DCX_uc011msv.1_Missense_Mutation_p.R183C|DCX_uc004epe.2_Missense_Mutation_p.R102C|DCX_uc004epf.2_Missense_Mutation_p.R102C|DCX_uc004epg.2_Missense_Mutation_p.R102C	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	183	Doublecortin 1.		R -> S (in LISX1).		axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TAAATGTAACGCACTCCCTGA	0.522000													45	61					0	0	1	0	0	
TRPC5	7224	broad.mit.edu	37	X	111195335	111195335	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:111195335C>T	uc004epl.1	-	2	1233	c.314G>A	c.(313-315)CGC>CAC	p.R105H	TRPC5_uc004epm.1_Missense_Mutation_p.R105H	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	105	ANK 3.|Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						CACTTCCTTGCGTATGGCATA	0.542000													62	97					0	0	1	0	0	
SLC6A14	11254	broad.mit.edu	37	X	115572199	115572199	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:115572199T>G	uc004eqi.2	+	3	384	c.280T>G	c.(280-282)TGT>GGT	p.C94G	SLC6A14_uc011mtm.1_RNA	NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	94					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	CTTTCTGGAGTGTTCACTGGG	0.388000													114	181					0	0	1	0	0	
KLHL13	90293	broad.mit.edu	37	X	117043339	117043339	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:117043339G>A	uc004eql.2	-	5	1353	c.1291C>T	c.(1291-1293)CGC>TGC	p.R431C	KLHL13_uc004eqk.2_Missense_Mutation_p.R380C|KLHL13_uc011mtn.1_Missense_Mutation_p.R271C|KLHL13_uc011mto.1_Missense_Mutation_p.R425C|KLHL13_uc011mtp.1_Missense_Mutation_p.R433C|KLHL13_uc004eqm.2_Missense_Mutation_p.R380C|KLHL13_uc011mtq.1_Missense_Mutation_p.R415C	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	431	Kelch 2.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						AAGAAGGTGCGCTTTTCATTT	0.398000													5	60					0	0	1	0	0	
RNF113A	7737	broad.mit.edu	37	X	119005267	119005267	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:119005267G>T	uc004esb.2	-	1	525	c.310C>A	c.(310-312)CGT>AGT	p.R104S	NDUFA1_uc004esc.3_5'Flank	NM_006978	NP_008909	O15541	R113A_HUMAN	ring finger protein 113A	104							nucleic acid binding|zinc ion binding			breast(2)	2						TTCGCCGAACGGGTGGATTTA	0.557000													122	220					2.09629e-50	2.27588e-50	1	1	0	
AKAP14	158798	broad.mit.edu	37	X	119037280	119037280	+	Missense_Mutation	SNP	T	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:119037280T>G	uc004ese.2	+	3	232	c.94T>G	c.(94-96)TAC>GAC	p.Y32D	AKAP14_uc004esd.2_Missense_Mutation_p.Y32D|AKAP14_uc004esf.2_Missense_Mutation_p.Y32D	NM_178813	NP_848928	Q86UN6	AKA28_HUMAN	A kinase (PRKA) anchor protein 14 isoform a	32						cytoplasm					0						AGACAAGAACTACGAGGATGA	0.408000													40	61					0	0	1	0	0	
RHOXF2B	727940	broad.mit.edu	37	X	119293304	119293304	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:119293304C>T	uc004esl.3	+	2	653	c.463C>T	c.(463-465)CGC>TGC	p.R155C		NM_001099685	NP_001093155	P0C7M4	RHF2B_HUMAN	Rhox homeobox family, member 2B	155	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CATTTTCCAACGCGAGCAGTT	0.657000													17	18					0	0	1	0	0	
FAM70A	55026	broad.mit.edu	37	X	119410901	119410901	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:119410901G>A	uc004eso.3	-	8	813	c.586C>T	c.(586-588)CGG>TGG	p.R196W	FAM70A_uc004esp.3_Missense_Mutation_p.R172W|FAM70A_uc010nqo.2_Intron	NM_017938	NP_060408	Q5JRV8	FA70A_HUMAN	hypothetical protein LOC55026 isoform 1	196						integral to membrane				lung(1)|breast(1)	2						ATCTCCACCCGGCTGGACAGG	0.582000													26	76					0	0	1	0	0	
CUL4B	8450	broad.mit.edu	37	X	119691798	119691798	+	Missense_Mutation	SNP	T	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:119691798T>A	uc004esw.2	-	4	1144	c.707A>T	c.(706-708)AAT>ATT	p.N236I	CUL4B_uc004esv.2_Missense_Mutation_p.N218I	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	236					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TTCTTCTAAATTGTACTTAAT	0.328000													12	18					0	0	1	0	0	
CUL4B	8450	broad.mit.edu	37	X	119691804	119691804	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:119691804T>C	uc004esw.2	-	4	1138	c.701A>G	c.(700-702)AAG>AGG	p.K234R	CUL4B_uc004esv.2_Missense_Mutation_p.K216R	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	cullin 4B isoform 1	234					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			lung(1)|central_nervous_system(1)|pancreas(1)	3						TAAATTGTACTTAATTGAAGT	0.323000													11	21					0	0	1	0	0	
GLUD2	2747	broad.mit.edu	37	X	120182193	120182193	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:120182193G>A	uc004eto.2	+	1	732	c.655G>A	c.(655-657)GTT>ATT	p.V219I		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	219					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TGGTCCTGGCGTTGATGTGCC	0.458000													57	83					0	0	1	0	0	
ODZ1	10178	broad.mit.edu	37	X	123539072	123539072	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:123539072G>A	uc004euj.2	-	26	5243	c.5179C>T	c.(5179-5181)CGT>TGT	p.R1727C	ODZ1_uc011muj.1_Missense_Mutation_p.R1733C|ODZ1_uc010nqy.2_Missense_Mutation_p.R1734C	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1727	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						AAAGTGACACGCAGGGAACCA	0.537000													35	56					0	0	1	0	0	
OCRL	4952	broad.mit.edu	37	X	128703273	128703273	+	Missense_Mutation	SNP	G	A	A	rs137853260		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:128703273G>A	uc004euq.2	+	15	1664	c.1499G>A	c.(1498-1500)CGA>CAA	p.R500Q	OCRL_uc004eur.2_Missense_Mutation_p.R500Q	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	500			R -> G (in OCRL).		regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						TGGTGTGACCGAATTCTTTGG	0.428000													57	93					0	0	1	0	0	
OCRL	4952	broad.mit.edu	37	X	128723844	128723844	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:128723844G>A	uc004euq.2	+	23	2657	c.2492G>A	c.(2491-2493)TGC>TAC	p.C831Y	OCRL_uc004eur.2_Missense_Mutation_p.C823Y|OCRL_uc010nrb.2_Intron	NM_000276	NP_000267	Q01968	OCRL_HUMAN	phosphatidylinositol polyphosphate 5-phosphatase	831	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			lung(2)|ovary(1)|kidney(1)	4						CTTCCGAGATGCCATAGAAAT	0.413000													44	59					0	0	1	0	0	
UTP14A	10813	broad.mit.edu	37	X	129055422	129055422	+	Missense_Mutation	SNP	G	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:129055422G>C	uc004euz.2	+	11	1235	c.1207G>C	c.(1207-1209)GGA>CGA	p.G403R	UTP14A_uc011mup.1_Missense_Mutation_p.G351R|UTP14A_uc011muq.1_Missense_Mutation_p.G349R|UTP14A_uc004eva.1_Missense_Mutation_p.G109R	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	403					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						TGAGGCCCATGGAGTTTCTGA	0.507000													22	34					0	0	1	0	0	
RAB33A	9363	broad.mit.edu	37	X	129306239	129306239	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:129306239C>A	uc004evl.2	+	1	467	c.203C>A	c.(202-204)ACC>AAC	p.T68N	RAB33A_uc010nre.2_RNA	NM_004794	NP_004785	Q14088	RB33A_HUMAN	Ras-related protein Rab-33A	68					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding				0						ACTGAAGCCACCATCGGCGTG	0.592000													37	70					2.32173e-10	2.42324e-10	1	1	0	
GPR119	139760	broad.mit.edu	37	X	129518465	129518465	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:129518465C>A	uc011muv.1	-	1	957	c.957G>T	c.(955-957)AGG>AGT	p.R319S		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	319	Cytoplasmic (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						AGGAACTTTCCCTGGGCCTCT	0.537000													41	65					8.20599e-20	8.779e-20	1	1	0	
FAM45B	55855	broad.mit.edu	37	X	129629153	129629153	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:129629153G>A	uc010nrh.2	+	1	239	c.21G>A	c.(19-21)GCG>GCA	p.A7A	uc004evu.2_RNA	NM_207009	NP_996892			hypothetical protein LOC404636											skin(1)	1				all cancers(201;0.0293)		CCGAGTTGGCGGACACTCAGC	0.512000													21	38					0	0	1	0	0	
OR13H1	347468	broad.mit.edu	37	X	130678359	130678359	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:130678359C>T	uc011muw.1	+	1	312	c.312C>T	c.(310-312)TCC>TCT	p.S104S	IGSF1_uc004ewf.2_Intron	NM_001004486	NP_001004486	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Acute lymphoblastic leukemia(192;0.000636)					CGAGTGTCTCCTTGGCTTTGG	0.512000													6	80					0	0	1	0	0	
RAP2C	57826	broad.mit.edu	37	X	131351264	131351264	+	Missense_Mutation	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:131351264A>T	uc004ewp.2	-	2	817	c.33T>A	c.(31-33)AGT>AGA	p.S11R	uc004ewr.1_5'Flank|RAP2C_uc004ewo.2_Intron|RAP2C_uc010nrk.2_Intron|RAP2C_uc004ewq.3_Missense_Mutation_p.S11R	NM_021183	NP_067006	Q9Y3L5	RAP2C_HUMAN	RAP2C, member of RAS oncogene family precursor	11	GTP (By similarity).				negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					CAACCCCTCCACTCCCTAACA	0.517000													118	179					0	0	1	0	0	
GPC4	2239	broad.mit.edu	37	X	132439845	132439845	+	Silent	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:132439845G>A	uc004exc.1	-	6	1322	c.1110C>T	c.(1108-1110)CCC>CCT	p.P370P	GPC4_uc011mvg.1_Silent_p.P300P	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	370					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					GGCGTTCCTCGGGGTGATGTG	0.542000													108	207					0	0	1	0	0	
GPR112	139378	broad.mit.edu	37	X	135428783	135428783	+	Missense_Mutation	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:135428783T>C	uc004ezu.1	+	6	3209	c.2918T>C	c.(2917-2919)ATA>ACA	p.I973T	GPR112_uc010nsb.1_Missense_Mutation_p.I768T|GPR112_uc010nsc.1_Missense_Mutation_p.I740T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	973	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACCACAAGGATATCAGAAACC	0.498000													85	134					0	0	1	0	0	
VGLL1	51442	broad.mit.edu	37	X	135630815	135630815	+	Silent	SNP	T	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:135630815T>C	uc004ezy.2	+	3	452	c.282T>C	c.(280-282)CCT>CCC	p.P94P	MIR934_hsa-mir-934|MI0005756_5'Flank	NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					CAGAAGTACCTGTCACAAACC	0.517000													107	164					0	0	1	0	0	
MCF2	4168	broad.mit.edu	37	X	138729031	138729031	+	Silent	SNP	A	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:138729031A>T	uc011mwn.1	-	3	318	c.312T>A	c.(310-312)ATT>ATA	p.I104I	MCF2_uc004faw.2_Silent_p.I19I|MCF2_uc011mwo.1_Silent_p.I19I			P10911	MCF2_HUMAN	SubName: Full=MCF.2 cell line derived transforming sequence;	Error:Variant_position_missing_in_P10911_after_alignment					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					CTGGAAACGTAATGATCCAAG	0.328000													8	8					0	0	1	0	0	
MAMLD1	10046	broad.mit.edu	37	X	149671777	149671777	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:149671777C>T	uc004fee.1	+	5	2350	c.2274C>T	c.(2272-2274)TGC>TGT	p.C758C	MAMLD1_uc011mxu.1_Intron|MAMLD1_uc011mxv.1_Silent_p.C733C|MAMLD1_uc011mxw.1_Silent_p.C644C	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	758					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					tgcctagctgcgacgccacag	0.199000													6	10					0	0	1	0	0	
HMGB3	3149	broad.mit.edu	37	X	150154642	150154642	+	Missense_Mutation	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:150154642C>A	uc004fep.2	+	3	361	c.269C>A	c.(268-270)CCT>CAT	p.P90H	HMGB3_uc004feq.2_Missense_Mutation_p.P90H|HMGB3_uc004fer.2_Missense_Mutation_p.P90H	NM_005342	NP_005333	O15347	HMGB3_HUMAN	high-mobility group box 3	90					DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					AAGAAGGATCCTAATGCTCCC	0.403000													15	20					2.31682e-05	2.35817e-05	1	1	0	
GPR50	9248	broad.mit.edu	37	X	150349152	150349152	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:150349152G>A	uc010ntg.1	+	2	1232	c.1097G>A	c.(1096-1098)CGG>CAG	p.R366Q	uc004fes.1_5'Flank	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	366	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					ATGAATGTCCGGAATGTTCCA	0.617000													77	77					0	0	1	0	0	
CETN2	1069	broad.mit.edu	37	X	151996414	151996414	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:151996414G>A	uc004fgq.2	-	5	537	c.490C>T	c.(490-492)CGC>TGC	p.R164C	CETN2_uc004fgr.2_Missense_Mutation_p.R93C	NM_004344	NP_004335	P41208	CETN2_HUMAN	caltractin	164	EF-hand 4.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					TTCATGATGCGCAGGAACTCT	0.393000								Direct_reversal_of_damage|NER					43	98					0	0	1	0	0	
ATP2B3	492	broad.mit.edu	37	X	152825205	152825205	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:152825205G>A	uc004fht.1	+	16	2770	c.2644G>A	c.(2644-2646)GTG>ATG	p.V882M	ATP2B3_uc004fhs.1_Missense_Mutation_p.V882M|ATP2B3_uc010nuf.1_5'Flank|ATP2B3_uc004fhu.1_5'Flank	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	882	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTCAAAGCCGTGCAGATGTT	0.617000													29	57					0	0	1	0	0	
L1CAM	3897	broad.mit.edu	37	X	153131206	153131206	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153131206G>A	uc004fjb.2	-	19	2608	c.2500C>T	c.(2500-2502)CGG>TGG	p.R834W	L1CAM_uc004fjc.2_Missense_Mutation_p.R834W|L1CAM_uc010nuo.2_Missense_Mutation_p.R829W	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	834	Extracellular (Potential).|Fibronectin type-III 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCACCGGCCGCCACTTGACC	0.587000													89	138					0	0	1	0	0	
HCFC1	3054	broad.mit.edu	37	X	153219633	153219633	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153219633G>A	uc004fjp.2	-	17	4745	c.4217C>T	c.(4216-4218)GCG>GTG	p.A1406V		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	1406					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCCAGCAGCGCGGTGCCAGC	0.672000													18	30					0	0	1	0	0	
HCFC1	3054	broad.mit.edu	37	X	153227748	153227748	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153227748G>A	uc004fjp.2	-	5	1250	c.722C>T	c.(721-723)ACG>ATG	p.T241M		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	241	Kelch 4.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTATTCCACGTCAGGGTGTC	0.567000													11	18					0	0	1	0	0	
MECP2	4204	broad.mit.edu	37	X	153296753	153296753	+	Missense_Mutation	SNP	G	A	A	rs62621666		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153296753G>A	uc004fjv.2	-	4	752	c.526C>T	c.(526-528)CCC>TCC	p.P176S	MECP2_uc004fjw.2_Missense_Mutation_p.P188S	NM_004992	NP_004983	P51608	MECP2_HUMAN	methyl CpG binding protein 2 isoform 1	176					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGAGATTTGGGCTTCTTAGGT	0.607000													54	58					0	0	1	0	0	
OPN1LW	5956	broad.mit.edu	37	X	153420113	153420113	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153420113G>A	uc004fjz.3	+	4	676	c.643G>A	c.(643-645)GGG>AGG	p.G215R		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	215	Extracellular.				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCGTACCCCGGGGTGCAGTC	0.607000													60	150					0	0	1	0	0	
OPN1LW	5956	broad.mit.edu	37	X	153421957	153421957	+	Silent	SNP	C	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153421957C>A	uc004fjz.3	+	5	966	c.933C>A	c.(931-933)GCC>GCA	p.A311A		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	311	Helical; Name=7; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTACTTTGCCAAAAGTGCCA	0.537000													113	304					2.32265e-44	2.51897e-44	1	1	0	
FLNA	2316	broad.mit.edu	37	X	153593797	153593797	+	Missense_Mutation	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153593797C>T	uc004fkk.2	-	10	1736	c.1487G>A	c.(1486-1488)CGG>CAG	p.R496Q	FLNA_uc010nuu.1_Missense_Mutation_p.R496Q	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	496	Filamin 3.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCCTTCACCCGCACACCCTT	0.667000													21	42					0	0	1	0	0	
PLXNA3	55558	broad.mit.edu	37	X	153689624	153689624	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153689624C>T	uc004flm.2	+	3	953	c.780C>T	c.(778-780)TCC>TCT	p.S260S		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	260	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTTTCACGTCCAAGATCGTGC	0.592000													38	71					0	0	1	0	0	
SLC10A3	8273	broad.mit.edu	37	X	153715994	153715994	+	Missense_Mutation	SNP	G	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153715994G>T	uc004flq.2	-	3	1550	c.1286C>A	c.(1285-1287)GCC>GAC	p.A429D	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Missense_Mutation_p.A400D|SLC10A3_uc004flp.2_Missense_Mutation_p.A429D	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	429	Helical; (Potential).				organic anion transport	integral to membrane	bile acid:sodium symporter activity			ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CATGGCCAAGGCCAGCAGGCT	0.652000													18	23					5.03518e-11	5.27141e-11	1	1	0	
DKC1	1736	broad.mit.edu	37	X	154001491	154001491	+	Silent	SNP	C	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:154001491C>T	uc004fmm.2	+	11	1332	c.1122C>T	c.(1120-1122)GAC>GAT	p.D374D	DKC1_uc010nvf.2_Silent_p.D374D|SNORA56_uc004fmo.2_5'Flank	NM_001363	NP_001354	O60832	DKC1_HUMAN	dyskerin isoform 1	374					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGAGAGAGACACTTACCCTC	0.418000									Congenital_Dyskeratosis				28	68					0	0	1	0	0	
TMLHE	55217	broad.mit.edu	37	X	154754197	154754197	+	Missense_Mutation	SNP	C	T	T	rs145371120	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:154754197C>T	uc004fnn.2	-	3	444	c.278G>A	c.(277-279)CGC>CAC	p.R93H	TMLHE_uc004fno.2_Missense_Mutation_p.R93H|TMLHE_uc004fnp.3_Missense_Mutation_p.R93H	NM_018196	NP_060666	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	93					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			ovary(1)	1	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	ATCCAGGCTGCGCTGGTGAGT	0.488000													71	109					0	0	1	0	0	
SPRY3	10251	broad.mit.edu	37	X	155004342	155004342	+	Missense_Mutation	SNP	G	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:155004342G>A	uc004fnq.1	+	2	1263	c.809G>A	c.(808-810)TGC>TAC	p.C270Y	SPRY3_uc010nvl.1_Missense_Mutation_p.C171Y	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	270	Cys-rich.				multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AACACTGTGTGCAGAAAGATC	0.562000													63	72					0	0	1	0	0	
DVL1	1855	broad.mit.edu	37	1	1273434	1273434	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:1273434delG	uc001aer.3	-	14	1609	c.1562delC	c.(1561-1563)CCAfs	p.P521fs	DVL1_uc002quu.2_Frame_Shift_Del_p.P263fs|DVL1_uc009vka.2_Frame_Shift_Del_p.P204fs|DVL1_uc001aeu.1_Frame_Shift_Del_p.P280fs	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	546					canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GAAGCAGGGTGGGGGTCCCGG	0.692													13	29	---	---	---	---						.
MXRA8	54587	broad.mit.edu	37	1	1290110	1290110	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:1290110delG	uc001aew.2	-	5	932	c.901delC	c.(901-903)CGGfs	p.R301fs	MXRA8_uc001aex.3_Frame_Shift_Del_p.R301fs|MXRA8_uc001aey.3_Frame_Shift_Del_p.R301fs|MXRA8_uc010nyl.1_Frame_Shift_Del_p.R301fs|MXRA8_uc001aez.2_Frame_Shift_Del_p.R200fs|MXRA8_uc001afa.2_Frame_Shift_Del_p.R292fs	NM_032348	NP_115724	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8 precursor	301	Extracellular (Potential).					integral to membrane					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGAGAGCCCCGGGGGGGCGGC	0.741													9	12	---	---	---	---						.
MEGF6	1953	broad.mit.edu	37	1	3410404	3410404	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:3410404delC	uc001akl.2	-	34	4545	c.4318delG	c.(4318-4320)GCAfs	p.A1440fs	MEGF6_uc001akk.2_Intron	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	1440						extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		TCACAGGGTGCCCCCCCGTCA	0.667													4	4	---	---	---	---						.
NOL9	79707	broad.mit.edu	37	1	6605171	6605171	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:6605171delT	uc001ans.2	-	4	833	c.814delA	c.(814-816)AGGfs	p.R272fs	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	272					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		AGGCCTTTCCTTTTTTTCTCT	0.403													49	76	---	---	---	---						.
MASP2	10747	broad.mit.edu	37	1	11097818	11097818	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:11097818delC	uc001aru.2	-	7	961	c.940delG	c.(940-942)GTGfs	p.V314fs		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	314	Sushi 1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		TTGGCTTGCACAGGTGAAACG	0.502											OREG0013096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	95	---	---	---	---						.
ALPL	249	broad.mit.edu	37	1	21902394	21902394	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:21902394delC	uc001bet.2	+	10	1423	c.1166delC	c.(1165-1167)ACCfs	p.T389fs	ALPL_uc010odn.1_Frame_Shift_Del_p.T337fs|ALPL_uc010odo.1_Frame_Shift_Del_p.T334fs|ALPL_uc010odp.1_Frame_Shift_Del_p.T312fs|ALPL_uc001beu.3_Frame_Shift_Del_p.T389fs	NM_000478	NP_000469	P05186	PPBT_HUMAN	tissue-nonspecific alkaline phosphatase	389					response to vitamin D|skeletal system development	anchored to membrane|cytoplasm|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		all_lung(284;2.19e-05)|Lung NSC(340;2.22e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;8.7e-28)|COAD - Colon adenocarcinoma(152;1.57e-05)|GBM - Glioblastoma multiforme(114;2.66e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000177)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00856)|READ - Rectum adenocarcinoma(331;0.0623)|Lung(427;0.146)	Amifostine(DB01143)	GGTGGATACACCCCCCGTGGC	0.612													64	125	---	---	---	---						.
KIAA1522	57648	broad.mit.edu	37	1	33236735	33236735	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:33236735delC	uc001bvv.2	+	6	1914	c.1778delC	c.(1777-1779)ACCfs	p.T593fs	KIAA1522_uc001bvu.1_Frame_Shift_Del_p.T652fs|KIAA1522_uc010ohm.1_Frame_Shift_Del_p.T604fs|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	593	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CAGATATTGACCCCCCTGGGT	0.637													61	98	---	---	---	---						.
FOXD2	2306	broad.mit.edu	37	1	47903854	47903854	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:47903854delC	uc001crm.2	+	1	2166	c.47delC	c.(46-48)TCCfs	p.S16fs		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	16					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		TCCGAGAGCTCCCCGGCCGCG	0.677													4	7	---	---	---	---						.
HOOK1	51361	broad.mit.edu	37	1	60314140	60314140	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:60314140delA	uc009wad.2	+	12	1185	c.1083delA	c.(1081-1083)TTAfs	p.L361fs	HOOK1_uc001czo.2_Frame_Shift_Del_p.L361fs|HOOK1_uc001czp.2_RNA|HOOK1_uc010oor.1_Frame_Shift_Del_p.L319fs	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	hook homolog 1	361	Potential.|Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			ovary(1)|breast(1)	2	all_cancers(7;0.000129)					AAGAAGAATTAAAAAAAGCAA	0.318													33	76	---	---	---	---						.
KANK4	163782	broad.mit.edu	37	1	62740426	62740427	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:62740426_62740427insG	uc001dah.3	-	3	726_727	c.349_350insC	c.(349-351)CAGfs	p.Q117fs	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	117										ovary(3)|skin(2)|lung(1)	6						TGTTGAGGCCTGGGGGGCATTA	0.609													29	57	---	---	---	---						.
RAVER2	55225	broad.mit.edu	37	1	65296646	65296647	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:65296646_65296647insA	uc001dbs.1	+	12	2093_2094	c.2015_2016insA	c.(2014-2016)TTAfs	p.L672fs	RAVER2_uc001dbt.1_Frame_Shift_Ins_p.L564fs|RAVER2_uc010opb.1_Frame_Shift_Ins_p.L397fs	NM_018211	NP_060681	Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	685						cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)	1						GAAACTTACTTAAAAAAGAAGC	0.446													54	115	---	---	---	---						.
LRRC7	57554	broad.mit.edu	37	1	70504693	70504693	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:70504693delA	uc001dep.2	+	19	3102	c.3072delA	c.(3070-3072)ACAfs	p.T1024fs	LRRC7_uc009wbg.2_Frame_Shift_Del_p.T308fs|LRRC7_uc001deq.2_Frame_Shift_Del_p.T265fs	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1024						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CTTCTATGACAAAAAAAGTCT	0.453													14	23	---	---	---	---						.
ZRANB2	9406	broad.mit.edu	37	1	71544212	71544212	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:71544212delC	uc001dft.2	-	3	213	c.146delG	c.(145-147)GGCfs	p.G49fs	uc001dfu.1_5'Flank|ZRANB2_uc001dfs.2_Frame_Shift_Del_p.G49fs	NM_203350	NP_976225	O95218	ZRAB2_HUMAN	zinc finger protein 265 isoform 1	49					mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TATTTCAGTGCCCCCAGCTTT	0.358													59	101	---	---	---	---						.
PKN2	5586	broad.mit.edu	37	1	89206848	89206848	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:89206848delA	uc001dmn.2	+	2	568	c.226delA	c.(226-228)AAAfs	p.K76fs	PKN2_uc001dmm.1_Frame_Shift_Del_p.K76fs|PKN2_uc010osp.1_Frame_Shift_Del_p.K76fs|PKN2_uc010osq.1_Intron|PKN2_uc009wcv.2_Frame_Shift_Del_p.K76fs	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	76	REM 1.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		CACAACAGATAAAAAAAGTTT	0.308													22	15	---	---	---	---						.
TGFBR3	7049	broad.mit.edu	37	1	92177814	92177814	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:92177814delG	uc001doh.2	-	13	2618	c.2152delC	c.(2152-2154)CAGfs	p.Q718fs	TGFBR3_uc009wde.2_Frame_Shift_Del_p.Q413fs|TGFBR3_uc010osy.1_Frame_Shift_Del_p.Q676fs|TGFBR3_uc001doi.2_Frame_Shift_Del_p.Q717fs|TGFBR3_uc001doj.2_Frame_Shift_Del_p.Q717fs	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	718	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GGCAACTTCTGGGGGTGCTTC	0.463													11	23	---	---	---	---						.
GPR61	83873	broad.mit.edu	37	1	110086776	110086778	+	In_Frame_Del	DEL	GAG	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:110086776_110086778delGAG	uc001dxy.2	+	2	1815_1817	c.1132_1134delGAG	c.(1132-1134)GAGdel	p.E379del		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	379	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGGCTCCATTGAGGAGAACTTCC	0.611													28	36	---	---	---	---						.
SPAG17	200162	broad.mit.edu	37	1	118567980	118567980	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:118567980delG	uc001ehk.2	-	27	3858	c.3790delC	c.(3790-3792)CAGfs	p.Q1264fs		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1264						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTCACCCTCTGGGGGTAGCTC	0.458													78	46	---	---	---	---						.
GJA5	2702	broad.mit.edu	37	1	147230552	147230552	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:147230552delG	uc001eps.1	-	2	936	c.795delC	c.(793-795)CCCfs	p.P265fs	GJA5_uc001ept.1_Frame_Shift_Del_p.P265fs	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	265	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			GATTAAAGTCGGGGGGTGGTG	0.532													43	80	---	---	---	---						.
DENND4B	9909	broad.mit.edu	37	1	153906026	153906026	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:153906026delG	uc001fdd.1	-	20	3664	c.3263delC	c.(3262-3264)CCAfs	p.P1088fs	uc001fdc.1_Intron	NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	1088										ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCGGCGGGCTGGGGGTGGCAG	0.692													11	22	---	---	---	---						.
DCST2	127579	broad.mit.edu	37	1	155006137	155006137	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155006137delC	uc001fgm.2	-	1	121	c.41delG	c.(40-42)GGAfs	p.G14fs	DCST2_uc009wpb.2_RNA|DCST1_uc010per.1_5'Flank|DCST1_uc001fgn.1_5'Flank|DCST1_uc010pes.1_5'Flank	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	14	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			AGGCTCCTCTCCCCCCAAGGG	0.587													30	49	---	---	---	---						.
THBS3	7059	broad.mit.edu	37	1	155172646	155172646	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155172646delG	uc001fix.2	-	8	937	c.914delC	c.(913-915)CCTfs	p.P305fs	RAG1AP1_uc010pey.1_Intron|THBS3_uc009wqi.2_Frame_Shift_Del_p.P296fs|THBS3_uc001fiz.2_Frame_Shift_Del_p.P305fs|THBS3_uc001fiy.2_5'UTR|THBS3_uc010pfu.1_Frame_Shift_Del_p.P185fs|THBS3_uc010pfv.1_RNA|THBS3_uc001fja.2_RNA	NM_007112	NP_009043	P49746	TSP3_HUMAN	thrombospondin 3 precursor	305	EGF-like 1.				cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(3)|ovary(2)	5	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CTGCAGGCCAGGGGGGCAGGG	0.617													29	61	---	---	---	---						.
FAM189B	10712	broad.mit.edu	37	1	155224231	155224232	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155224231_155224232insC	uc001fjm.2	-	2	847_848	c.241_242insG	c.(241-243)GTGfs	p.V81fs	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_5'Flank|FAM189B_uc001fjn.2_Intron|FAM189B_uc001fjo.2_Intron|FAM189B_uc001fjp.2_Intron|FAM189B_uc001fjq.1_Frame_Shift_Ins_p.V81fs	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	81	Helical; (Potential).					integral to membrane	WW domain binding			ovary(1)|breast(1)	2						AATGCCAACCACCCCGGAGAAC	0.653													47	55	---	---	---	---						.
C1orf104	284618	broad.mit.edu	37	1	155291076	155291076	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155291076delC	uc001fki.2	-	2	481	c.204delG	c.(202-204)GGGfs	p.G68fs	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fkh.1_RNA|RUSC1_uc001fkj.2_Intron|RUSC1_uc001fkk.2_Intron|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank|RUSC1_uc001fkl.2_5'Flank	NM_001039517	NP_001034606	Q66K80	RUAS1_HUMAN	hypothetical protein LOC284618	68	Poly-Gly.										0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.32e-10)|all cancers(21;3.51e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TATTGCCCCACCCCCATCCTC	0.612													11	21	---	---	---	---						.
RUSC1	23623	broad.mit.edu	37	1	155296883	155296883	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:155296883delG	uc001fkj.2	+	8	2603	c.2374delG	c.(2374-2376)GGGfs	p.G792fs	RAG1AP1_uc010pey.1_Intron|C1orf104_uc001fki.2_5'Flank|RUSC1_uc001fkk.2_Frame_Shift_Del_p.G686fs|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_Frame_Shift_Del_p.G323fs|RUSC1_uc001fkl.2_Frame_Shift_Del_p.G382fs|RUSC1_uc001fkp.2_Frame_Shift_Del_p.G323fs|RUSC1_uc001fkq.2_Frame_Shift_Del_p.G217fs|RUSC1_uc010pgb.1_Frame_Shift_Del_p.G290fs|RUSC1_uc009wqp.1_Frame_Shift_Del_p.G317fs|RUSC1_uc001fkn.2_Frame_Shift_Del_p.G101fs|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Frame_Shift_Del_p.G323fs|RUSC1_uc001fks.2_Frame_Shift_Del_p.G101fs	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	792						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TGGAGTGCCTGGGGGCCCCGC	0.557													48	85	---	---	---	---						.
KLHDC9	126823	broad.mit.edu	37	1	161068706	161068706	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:161068706delC	uc001fxr.2	+	1	553	c.381delC	c.(379-381)TGCfs	p.C127fs	KLHDC9_uc001fxq.2_5'UTR|KLHDC9_uc001fxs.2_Frame_Shift_Del_p.C127fs	NM_152366	NP_689579	Q8NEP7	KLDC9_HUMAN	kelch/ankyrin repeat containing cyclin A1	127	Kelch 2.										0	all_cancers(52;1.28e-19)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CTGGTGACTGCCCCCCCGCCG	0.687													4	7	---	---	---	---						.
TMCO1	54499	broad.mit.edu	37	1	165737430	165737430	+	Frame_Shift_Del	DEL	T	-	-	rs146830030		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:165737430delT	uc001gdj.3	-	2	296	c.147delA	c.(145-147)AAAfs	p.K49fs	TMCO1_uc001gdl.3_5'UTR|TMCO1_uc001gdm.3_5'UTR|TMCO1_uc001gdk.3_Frame_Shift_Del_p.K37fs|TMCO1_uc001gdn.3_RNA|uc001gdo.2_5'Flank	NM_019026	NP_061899	Q9UM00	TMCO1_HUMAN	transmembrane and coiled-coil domains 1	49	Potential.					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				central_nervous_system(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					CATACTCACATTTTTTACTCT	0.363													12	27	---	---	---	---						.
ATP1B1	481	broad.mit.edu	37	1	169100834	169100834	+	RNA	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:169100834delA	uc001gfs.1	+	6		c.1078delA						P05026	AT1B1_HUMAN	Synthetic construct DNA, clone: pF1KB8186, Homo sapiens ATP1B1 gene for ATPase, Na+/K+ transporting, beta 1 polypeptide, without stop codon, in Flexi system.						ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	all_hematologic(923;0.208)					TTAATAAGTTAAAAAAAGATA	0.338													27	31	---	---	---	---						.
SLC9A11	284525	broad.mit.edu	37	1	173551149	173551150	+	Splice_Site	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:173551149_173551150insA	uc001giz.2	-	7	1064	c.641_splice	c.e7-1	p.D214_splice	SLC9A11_uc010pmq.1_Splice_Site	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11						sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						CATGTAAATCTAAAAAAAAGAA	0.327													13	18	---	---	---	---						.
SEC16B	89866	broad.mit.edu	37	1	177937055	177937056	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:177937055_177937056delTT	uc001gli.1	-	2	151_152	c.61_62delAA	c.(61-63)AAGfs	p.K21fs	SEC16B_uc001glk.1_5'UTR|SEC16B_uc009wwz.1_5'UTR|SEC16B_uc001glj.1_Frame_Shift_Del_p.K21fs|SEC16B_uc001gll.3_Frame_Shift_Del_p.K21fs	NM_033127	NP_149118	Q96JE7	SC16B_HUMAN	leucine zipper transcription regulator 2	21					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				ovary(3)|central_nervous_system(1)	4						GTCTGGATCCTTTGAGGGTGCT	0.550													16	27	---	---	---	---						.
SOAT1	6646	broad.mit.edu	37	1	179304653	179304653	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:179304653delT	uc001gml.2	+	4	253	c.190delT	c.(190-192)TTTfs	p.F64fs	SOAT1_uc010pni.1_5'UTR|SOAT1_uc001gmm.2_Frame_Shift_Del_p.F6fs|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_5'UTR	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	64					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	ATTGAAGCCATTTTTTATGAA	0.373													23	48	---	---	---	---						.
RNPEP	6051	broad.mit.edu	37	1	201966518	201966518	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:201966518delC	uc001gxd.2	+	5	955	c.926delC	c.(925-927)ACCfs	p.T309fs	RNPEP_uc001gxe.2_Frame_Shift_Del_p.T10fs|RNPEP_uc001gxf.2_Frame_Shift_Del_p.T178fs	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase	309					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			upper_aerodigestive_tract(1)	1				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		ACCTTTGTCACCCCCTGCCTG	0.562													55	95	---	---	---	---						.
PTPN7	5778	broad.mit.edu	37	1	202128509	202128510	+	Frame_Shift_Ins	INS	-	C	C	rs4073458		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:202128509_202128510insC	uc001gxm.1	-	2	152_153	c.21_22insG	c.(19-24)GGGCGCfs	p.G7fs	PTPN7_uc001gxl.1_Frame_Shift_Ins_p.G46fs|PTPN7_uc001gxn.1_Frame_Shift_Ins_p.G7fs|PTPN7_uc010ppv.1_5'UTR|PTPN7_uc010ppw.1_5'UTR|PTPN7_uc010ppx.1_Frame_Shift_Ins_p.G81fs|PTPN7_uc010ppy.1_RNA|PTPN7_uc001gxo.1_5'Flank	NM_002832	NP_002823	P35236	PTN7_HUMAN	protein tyrosine phosphatase, non-receptor type	7_8						cytosol|internal side of plasma membrane	protein binding|protein tyrosine phosphatase activity			skin(1)	1						GCTCTGGAGCGCCCCCCATGGG	0.634													32	48	---	---	---	---						.
PLEKHA6	22874	broad.mit.edu	37	1	204210890	204210891	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:204210890_204210891insG	uc001hau.2	-	16	2541_2542	c.2224_2225insC	c.(2224-2226)CTGfs	p.L742fs	PLEKHA6_uc009xau.1_RNA	NM_014935	NP_055750	Q9Y2H5	PKHA6_HUMAN	phosphoinositol 3-phosphate-binding protein-3	742										ovary(3)|pancreas(1)	4	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GGGGGTGTCCAGGGGCAATGTC	0.535													42	66	---	---	---	---						.
FBXO28	23219	broad.mit.edu	37	1	224301881	224301881	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:224301881delA	uc001hoh.2	+	1	91	c.50delA	c.(49-51)CAAfs	p.Q17fs	FBXO28_uc009xef.2_Frame_Shift_Del_p.Q17fs|FBXO28_uc010pvc.1_5'UTR	NM_015176	NP_055991	Q9NVF7	FBX28_HUMAN	F-box protein 28 isoform a	17										ovary(2)|kidney(2)|lung(1)	5	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		GGCGGCGGCCAAGGCGACGGC	0.706													2	4	---	---	---	---						.
SCCPDH	51097	broad.mit.edu	37	1	246923498	246923499	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:246923498_246923499insT	uc001ibr.2	+	9	1306_1307	c.959_960insT	c.(958-960)TATfs	p.Y320fs		NM_016002	NP_057086	Q8NBX0	SCPDH_HUMAN	saccharopine dehydrogenase (putative)	320						midbody	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity			ovary(1)	1	all_cancers(71;6.8e-05)|all_epithelial(71;7.93e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0545)|Lung NSC(105;0.0618)	all_cancers(173;0.0343)	OV - Ovarian serous cystadenocarcinoma(106;0.00323)	GBM - Glioblastoma multiforme(49;0.0896)		TCCTTTGGCTATTTTTCAAAAC	0.287													21	38	---	---	---	---						.
ZNF496	84838	broad.mit.edu	37	1	247486457	247486457	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr1:247486457delG	uc001ico.2	-	5	1115	c.650delC	c.(649-651)CCGfs	p.P217fs	ZNF496_uc009xgv.2_Frame_Shift_Del_p.P217fs|ZNF496_uc001icp.2_Frame_Shift_Del_p.P217fs|ZNF496_uc010pyv.1_Frame_Shift_Del_p.P217fs	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	217					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			ACCACTCACCGGGGGTAGCTG	0.522													33	54	---	---	---	---						.
LARP4B	23185	broad.mit.edu	37	10	890939	890939	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:890939delT	uc001ifs.1	-	5	528	c.487delA	c.(487-489)ACAfs	p.T163fs		NM_015155	NP_055970	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	163	HTH La-type RNA-binding.						nucleotide binding|RNA binding			ovary(2)|central_nervous_system(1)	3						AATTCCAATGTTTTTTTAAGT	0.353													37	59	---	---	---	---						.
CUBN	8029	broad.mit.edu	37	10	17107573	17107574	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:17107573_17107574insA	uc001ioo.2	-	22	3124_3125	c.3072_3073insT	c.(3070-3075)TTTGTGfs	p.F1024fs		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1024_1025	CUB 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAGTCAGTCACAAACACCAGCA	0.421													61	129	---	---	---	---						.
PTPLA	9200	broad.mit.edu	37	10	17636370	17636370	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:17636370delA	uc001ipg.2	-	6	653	c.618delT	c.(616-618)TTTfs	p.F206fs		NM_014241	NP_055056	B0YJ81	HACD1_HUMAN	protein tyrosine phosphatase-like, member A	206	Helical; (Potential).				fatty acid biosynthetic process|multicellular organismal development|signal transduction	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein tyrosine phosphatase activity			central_nervous_system(1)|skin(1)	2						ATAAGATGATAAAAAAATTAT	0.313													25	45	---	---	---	---						.
MRC1	4360	broad.mit.edu	37	10	17908612	17908612	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:17908612delG	uc001ipk.2	+	12	1928	c.1825delG	c.(1825-1827)GGGfs	p.G609fs		NM_002438	NP_002429	P22897	MRC1_HUMAN	mannose receptor C type 1 precursor	609	C-type lectin 3.|Extracellular (Potential).				receptor-mediated endocytosis	endosome membrane|integral to plasma membrane	mannose binding|receptor activity				0						CGGGATTGCAGGGGGCTTATG	0.512													11	4	---	---	---	---						.
PTCHD3	374308	broad.mit.edu	37	10	27687763	27687763	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:27687763delA	uc001itu.2	-	4	1882	c.1764delT	c.(1762-1764)TTTfs	p.F588fs		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	588					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						AATAGTCTCTAAAAAACAAAC	0.373													24	32	---	---	---	---						.
TET1	80312	broad.mit.edu	37	10	70332153	70332153	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:70332153delA	uc001jok.3	+	2	563	c.58delA	c.(58-60)AAAfs	p.K20fs		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	20					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						AGATGTAAACAAAAAAAAGAA	0.413													9	17	---	---	---	---						.
KIF20B	9585	broad.mit.edu	37	10	91514406	91514406	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:91514406delT	uc001kgs.1	+	26	4551	c.4479delT	c.(4477-4479)CGTfs	p.R1493fs	KIF20B_uc001kgr.1_Frame_Shift_Del_p.R1453fs|KIF20B_uc001kgt.1_Frame_Shift_Del_p.R704fs|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1493					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						ACAGGGAGCGTTTTTTTAAGC	0.328													38	46	---	---	---	---						.
ZNF518A	9849	broad.mit.edu	37	10	97920218	97920218	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:97920218delA	uc001klp.2	+	7	4997	c.4140delA	c.(4138-4140)TCAfs	p.S1380fs	ZNF518A_uc001klo.1_3'UTR|ZNF518A_uc001klq.2_3'UTR|ZNF518A_uc001klr.2_3'UTR	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		TTTCATTGTCAAAAAGAACTA	0.318													30	63	---	---	---	---						.
C10orf12	26148	broad.mit.edu	37	10	98742785	98742785	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:98742785delA	uc001kmv.2	+	1	1745	c.1638delA	c.(1636-1638)TCAfs	p.S546fs		NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	546										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		CAAAACGTTCAAAAAAAGAAG	0.443													38	56	---	---	---	---						.
CNNM1	26507	broad.mit.edu	37	10	101089318	101089318	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:101089318delG	uc001kpp.3	+	1	463	c.174delG	c.(172-174)GAGfs	p.E58fs	CNNM1_uc009xwe.2_Frame_Shift_Del_p.E58fs|CNNM1_uc010qpi.1_Frame_Shift_Del_p.E58fs|CNNM1_uc009xwf.2_Frame_Shift_Del_p.E58fs	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	58					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		TGTCCCTGGAGGGGGGCACCC	0.632													7	5	---	---	---	---						.
KIAA1598	57698	broad.mit.edu	37	10	118708437	118708437	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:118708437delT	uc009xyw.2	-	7	1104	c.606delA	c.(604-606)AAAfs	p.K202fs	KIAA1598_uc001lcz.3_Frame_Shift_Del_p.K202fs|KIAA1598_uc010qso.1_Frame_Shift_Del_p.K142fs|KIAA1598_uc010qsp.1_Frame_Shift_Del_p.K202fs|KIAA1598_uc010qsq.1_Frame_Shift_Del_p.K142fs|KIAA1598_uc001lcy.3_Frame_Shift_Del_p.K172fs	NM_001127211	NP_001120683	A0MZ66	SHOT1_HUMAN	shootin1 isoform a	202	Potential.				axon guidance	axon					0				all cancers(201;0.00494)		CTCTATTGCATTTTTCTAAGA	0.318													12	13	---	---	---	---						.
NKX6-2	84504	broad.mit.edu	37	10	134598431	134598431	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr10:134598431delC	uc001llr.2	-	3	908	c.823delG	c.(823-825)GACfs	p.D275fs		NM_177400	NP_796374	Q9C056	NKX62_HUMAN	NK6 transcription factor related, locus 2	275						nucleus	sequence-specific DNA binding transcription factor activity				0		all_cancers(35;2.79e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0584)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;4.06e-05)|Epithelial(32;5.53e-05)|all cancers(32;5.99e-05)		CACAAGGCGTCCCCCGCGCCG	0.637													10	21	---	---	---	---						.
RRP8	23378	broad.mit.edu	37	11	6623374	6623374	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:6623374delG	uc001med.2	-	2	250	c.171delC	c.(169-171)CCCfs	p.P57fs	ILK_uc001mee.2_5'Flank|ILK_uc001mef.2_5'Flank|ILK_uc010rap.1_5'Flank|ILK_uc010raq.1_5'Flank|ILK_uc001meg.2_5'Flank|ILK_uc001meh.2_5'Flank	NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	57					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						TACATAGGCTGGGGGGATGCT	0.557													33	76	---	---	---	---						.
ILK	3611	broad.mit.edu	37	11	6629392	6629392	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:6629392delC	uc001mee.2	+	3	341	c.206delC	c.(205-207)ACCfs	p.T69fs	ILK_uc001mef.2_Frame_Shift_Del_p.T69fs|ILK_uc010rap.1_Intron|ILK_uc010raq.1_Frame_Shift_Del_p.T69fs|ILK_uc001meg.2_5'UTR|ILK_uc001meh.2_Frame_Shift_Del_p.T69fs|ILK_uc001mei.2_5'Flank	NM_001014794	NP_001014794	Q13418	ILK_HUMAN	integrin-linked kinase	69	Interaction with LIMS1.|ANK 3.				cell junction assembly|cell proliferation|cell-matrix adhesion|integrin-mediated signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent	cytosol|focal adhesion	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)	1		Breast(177;7.61e-05)|Medulloblastoma(188;0.00263)|all_neural(188;0.026)|all_lung(207;0.152)		Epithelial(150;5.49e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00012)|Lung(200;0.00942)|LUSC - Lung squamous cell carcinoma(625;0.0163)		GGGGATGACACCCCCCTGCAT	0.557													35	58	---	---	---	---						.
SAAL1	113174	broad.mit.edu	37	11	18105214	18105214	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:18105214delT	uc001mnq.2	-	10	1157	c.1107delA	c.(1105-1107)AAAfs	p.K369fs	SAAL1_uc001mnr.2_Frame_Shift_Del_p.K368fs|SAAL1_uc001mns.2_RNA|SAAL1_uc009yhf.2_Frame_Shift_Del_p.K371fs	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	369					acute-phase response	extracellular region	binding				0						AGTTCTCTGGTTTTTTCTGAC	0.368													33	36	---	---	---	---						.
QSER1	79832	broad.mit.edu	37	11	32990615	32990615	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:32990615delA	uc001mty.2	+	10	5011	c.4744delA	c.(4744-4746)AAAfs	p.K1582fs	QSER1_uc001mtz.1_Frame_Shift_Del_p.K1343fs|QSER1_uc001mua.2_Frame_Shift_Del_p.K1087fs	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1582										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					ACCTCATATGAAAAAAATAGA	0.279													49	94	---	---	---	---						.
QSER1	79832	broad.mit.edu	37	11	32997895	32997895	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:32997895delA	uc001mty.2	+	13	5350	c.5083delA	c.(5083-5085)AAAfs	p.K1695fs	QSER1_uc001mtz.1_Frame_Shift_Del_p.K1456fs	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	1695										ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					TTCGGTGCAGAAAAAAAATGA	0.294													17	33	---	---	---	---						.
LRP4	4038	broad.mit.edu	37	11	46921056	46921057	+	Splice_Site	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:46921056_46921057insG	uc001ndn.3	-	5	577	c.431_splice	c.e5-1	p.D144_splice	LRP4_uc009ylh.1_Splice_Site_p.D95_splice	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein						endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		TGCGCATGTCTGGGGGGATGCG	0.599													39	66	---	---	---	---						.
TNKS1BP1	85456	broad.mit.edu	37	11	57070218	57070219	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:57070218_57070219insT	uc001njr.2	-	6	4709_4710	c.4397_4398insA	c.(4396-4398)AAGfs	p.K1466fs	TNKS1BP1_uc001njp.2_Frame_Shift_Ins_p.K38fs|TNKS1BP1_uc001njq.2_Frame_Shift_Ins_p.K38fs|TNKS1BP1_uc001njs.2_Frame_Shift_Ins_p.K1466fs	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1466	Tankyrase-binding.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				GAGCCACCGCCTTGGAGCTGCT	0.713													5	7	---	---	---	---						.
OR5B12	390191	broad.mit.edu	37	11	58207126	58207128	+	In_Frame_Del	DEL	AGA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:58207126_58207128delAGA	uc010rkh.1	-	1	497_499	c.497_499delTCT	c.(496-501)TTCTGT>TGT	p.F166del		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TTGGATCTACAGAAGGAGAGCCT	0.424													35	36	---	---	---	---						.
NRXN2	9379	broad.mit.edu	37	11	64375286	64375286	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:64375286delG	uc001oap.2	-	8	1894	c.1383delC	c.(1381-1383)CCCfs	p.P461fs	NRXN2_uc001oar.2_Frame_Shift_Del_p.P1507fs|NRXN2_uc001oas.2_Frame_Shift_Del_p.P1437fs|NRXN2_uc001oao.2_Frame_Shift_Del_p.P147fs|NRXN2_uc001oaq.2_Frame_Shift_Del_p.P1174fs	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	461	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CGTCGTCCGTGGGGGGGAGGC	0.697													8	7	---	---	---	---						.
MEN1	4221	broad.mit.edu	37	11	64573118	64573118	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:64573118delC	uc001obj.2	-	8	1262	c.1189delG	c.(1189-1191)GAGfs	p.E397fs	MAP4K2_uc001obh.2_5'Flank|MAP4K2_uc001obi.2_5'Flank|MAP4K2_uc010rnp.1_5'Flank|MEN1_uc001obk.2_Frame_Shift_Del_p.E397fs|MEN1_uc001obl.2_Frame_Shift_Del_p.E357fs|MEN1_uc001obm.2_Frame_Shift_Del_p.E392fs|MEN1_uc001obn.2_Frame_Shift_Del_p.E397fs|MEN1_uc001obo.2_Frame_Shift_Del_p.E397fs|MEN1_uc001obp.2_Frame_Shift_Del_p.E392fs|MEN1_uc001obq.2_Frame_Shift_Del_p.E397fs|MEN1_uc001obr.2_Frame_Shift_Del_p.E397fs	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	397					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						TGGCTTTGCTCCCCCGGCCGC	0.612			D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				15	32	---	---	---	---						.
TBX10	347853	broad.mit.edu	37	11	67402373	67402373	+	Frame_Shift_Del	DEL	G	-	-	rs144542807		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:67402373delG	uc001omp.2	-	3	379	c.291delC	c.(289-291)CCCfs	p.P97fs		NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	97	T-box.				anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCACCTGGAAGGGGGGGAACA	0.677													21	37	---	---	---	---						.
KRTAP5-10	387273	broad.mit.edu	37	11	71277026	71277026	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:71277026delG	uc001oqt.1	+	1	418	c.393delG	c.(391-393)AAGfs	p.K131fs		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	131	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GGGGCTCCAAGGGGGGCTGTG	0.483													94	169	---	---	---	---						.
UVRAG	7405	broad.mit.edu	37	11	75694431	75694433	+	In_Frame_Del	DEL	AAA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:75694431_75694433delAAA	uc001oxc.2	+	8	941_943	c.700_702delAAA	c.(700-702)AAAdel	p.K236del	UVRAG_uc010rrw.1_In_Frame_Del_p.K135del|UVRAG_uc001oxd.2_5'UTR|UVRAG_uc010rrx.1_5'UTR|UVRAG_uc009yuh.1_RNA	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	236	Potential.				DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						ATTTATTTAGAAAAAAAAAAGTG	0.310													15	26	---	---	---	---						.
MMP10	4319	broad.mit.edu	37	11	102647146	102647146	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:102647146delG	uc001phg.1	-	6	819	c.797delC	c.(796-798)CCTfs	p.P266fs		NM_002425	NP_002416	P09238	MMP10_HUMAN	matrix metalloproteinase 10 preproprotein	266					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			kidney(1)|lung(1)|breast(1)|central_nervous_system(1)	4	all_epithelial(12;0.00961)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0303)|Lung(13;0.0828)|all cancers(10;0.116)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0145)		AGTAGAGGCAGGGGGAGGTCC	0.463													33	38	---	---	---	---						.
Unknown	0	broad.mit.edu	37	11	104776330	104776330	+	RNA	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:104776330delT	uc001phy.2	-	1		c.3103delA			uc001phz.2_Intron|uc001pia.1_Intron					Homo sapiens mRNA; cDNA DKFZp667O0320 (from clone DKFZp667O0320).																		ACCTTCACTATTTTTTGTTTA	0.358													7	9	---	---	---	---						.
C11orf87	399947	broad.mit.edu	37	11	109294696	109294696	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:109294696delG	uc001pkn.2	+	2	711	c.337delG	c.(337-339)GGGfs	p.G113fs	C11orf87_uc010rwb.1_5'Flank	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	hypothetical protein LOC399947 precursor	113	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2						CCGCGGTGGCGGGGGGCTGCC	0.657													39	66	---	---	---	---						.
C11orf57	55216	broad.mit.edu	37	11	111953459	111953460	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:111953459_111953460insA	uc001pmr.3	+	6	1323_1324	c.642_643insA	c.(640-645)CTCAAAfs	p.L214fs	C11orf57_uc001pmw.3_Frame_Shift_Ins_p.L215fs|C11orf57_uc001pmt.3_Frame_Shift_Ins_p.L215fs|C11orf57_uc001pmv.3_Frame_Shift_Ins_p.L214fs|C11orf57_uc001pms.3_Frame_Shift_Ins_p.L186fs	NM_001082970	NP_001076439	Q6ZUT1	CK057_HUMAN	hypothetical protein LOC55216 isoform b	214_215	Lys-rich.									breast(2)|ovary(1)	3		all_cancers(61;9.8e-15)|all_epithelial(67;6.57e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.6e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;7.01e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0521)		AAAAGTCTCTCAAAAAACCTGC	0.411													30	54	---	---	---	---						.
HTR3B	9177	broad.mit.edu	37	11	113803746	113803749	+	Frame_Shift_Del	DEL	TCTA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:113803746_113803749delTCTA	uc001pok.2	+	6	694_697	c.627_630delTCTA	c.(625-630)CTTCTAfs	p.L209fs	HTR3B_uc001pol.2_Frame_Shift_Del_p.L198fs	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	209_210	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		AGTGGGAACTTCTATCTGTGTCCT	0.485													19	36	---	---	---	---						.
PCSK7	9159	broad.mit.edu	37	11	117095431	117095431	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:117095431delG	uc001pqr.2	-	7	1102	c.901delC	c.(901-903)CATfs	p.H301fs		NM_004716	NP_004707	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	301	Catalytic.|Extracellular (Potential).				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		CCAAGCTGATGGGGGCCATCC	0.557			T	IGH@	MLCLS								128	251	---	---	---	---						.
FOXR1	283150	broad.mit.edu	37	11	118850287	118850287	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:118850287delC	uc001pui.2	+	4	745	c.520delC	c.(520-522)CCCfs	p.P174fs	FOXR1_uc001puj.2_RNA|FOXR1_uc001puk.2_Intron	NM_181721	NP_859072	Q6PIV2	FOXR1_HUMAN	forkhead box R1	174	Fork-head.				embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CTGGTCCCGGCCCCCTCTCAA	0.592													42	97	---	---	---	---						.
MFRP	83552	broad.mit.edu	37	11	119213688	119213688	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr11:119213688delG	uc001pwj.2	-	10	1310	c.1150delC	c.(1150-1152)CACfs	p.H384fs	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Frame_Shift_Del_p.P308fs	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GAGACGAGGTGGGGGGGTGGC	0.622													5	6	---	---	---	---						.
Unknown	0	broad.mit.edu	37	12	6547958	6547958	+	RNA	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:6547958delA	uc001qoa.2	+	1		c.292delA				NR_003273				Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein) pseudogene 1 (SRP14P1), non-coding RNA.																		GAAGAGGGACAAAAAGAGCAA	0.428													10	9	---	---	---	---						.
ATN1	1822	broad.mit.edu	37	12	7045390	7045390	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:7045390delG	uc001qrw.1	+	5	1197	c.960delG	c.(958-960)CTGfs	p.L320fs	ATN1_uc001qrx.1_Frame_Shift_Del_p.L320fs|ATN1_uc001qry.1_Frame_Shift_Del_p.L319fs	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	320					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCCCTGGCCTGGGGGCCCAAC	0.647													41	76	---	---	---	---						.
C1R	715	broad.mit.edu	37	12	7242010	7242010	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:7242010delG	uc010sfy.1	-	5	706	c.647delC	c.(646-648)CCTfs	p.P216fs	C1R_uc010sfz.1_Frame_Shift_Del_p.P230fs|C1R_uc010sga.1_Frame_Shift_Del_p.P182fs	NM_001733	NP_001724	P00736	C1R_HUMAN	complement component 1, r subcomponent	216	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity				0					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCGCAGGTCAGGGGGGTAGGA	0.597													9	17	---	---	---	---						.
HTR7P1	93164	broad.mit.edu	37	12	13155743	13155743	+	RNA	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:13155743delA	uc010shq.1	+	1		c.2368delA			HEBP1_uc001rbd.2_5'Flank|HEBP1_uc001rbf.2_5'Flank|HTR7P1_uc001rbh.2_Intron	NR_002774				Homo sapiens 5-hydroxytryptamine (serotonin) receptor 7 pseudogene (HTR7P), non-coding RNA.												0						ACTACTGTAGAAAAAAAAGTC	0.433													10	9	---	---	---	---						.
HIST4H4	121504	broad.mit.edu	37	12	14923723	14923724	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:14923723_14923724insA	uc001rcf.3	-	1	342_343	c.295_296insT	c.(295-297)TATfs	p.Y99fs	HIST4H4_uc001rce.2_RNA	NM_175054	NP_778224	P62805	H4_HUMAN	histone cluster 4, H4	99					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						GCCGAAACCATAAAGGGTGCGA	0.574											OREG0021698	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	45	---	---	---	---						.
MLL2	8085	broad.mit.edu	37	12	49448408	49448408	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:49448408delC	uc001rta.3	-	3	303	c.303delG	c.(301-303)GGGfs	p.G101fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	101					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GCCCTGGGCTCCCCCCAGGGG	0.622			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			9	14	---	---	---	---						.
ACVR1B	91	broad.mit.edu	37	12	52345607	52345607	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:52345607delG	uc001rzn.2	+	1	122	c.80delG	c.(79-81)CGGfs	p.R27fs	ACVR1B_uc001rzl.2_Frame_Shift_Del_p.R27fs|ACVR1B_uc001rzm.2_Frame_Shift_Del_p.R27fs|ACVR1B_uc010snn.1_Frame_Shift_Del_p.R27fs	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	27	Extracellular (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	TCCGGGCCCCGGGGGGTCCAG	0.692													7	12	---	---	---	---						.
NAB2	4665	broad.mit.edu	37	12	57485461	57485461	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57485461delG	uc001smz.2	+	2	1015	c.637delG	c.(637-639)GGGfs	p.G213fs		NM_005967	NP_005958	Q15742	NAB2_HUMAN	NGFI-A binding protein 2	213					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CCCCCCTGCAGGGGGAGGAGT	0.701													22	14	---	---	---	---						.
MBD6	114785	broad.mit.edu	37	12	57920756	57920758	+	In_Frame_Del	DEL	CTT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57920756_57920758delCTT	uc001soj.1	+	7	2052_2054	c.1828_1830delCTT	c.(1828-1830)CTTdel	p.L611del	MBD6_uc001sok.1_In_Frame_Del_p.L478del|MBD6_uc001sol.1_RNA	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	611	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						ACCCTCAGACCTTCTTCCACCTC	0.635													66	134	---	---	---	---						.
DCTN2	10540	broad.mit.edu	37	12	57927805	57927806	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:57927805_57927806insG	uc001som.1	-	7	731_732	c.599_600insC	c.(598-600)CCAfs	p.P200fs	DCTN2_uc009zpu.1_Frame_Shift_Ins_p.P205fs|DCTN2_uc009zpv.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc009zpw.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc001soo.1_RNA|DCTN2_uc001son.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc001sop.1_Frame_Shift_Ins_p.P113fs|DCTN2_uc001soq.1_RNA|DCTN2_uc009zpx.1_Frame_Shift_Ins_p.P200fs	NM_006400	NP_006391	Q13561	DCTN2_HUMAN	dynactin 2	200					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			ovary(1)	1						GGCTGCTATCTGGGGGGGTCCC	0.500													25	48	---	---	---	---						.
DTX3	196403	broad.mit.edu	37	12	58001060	58001060	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:58001060delC	uc001sow.1	+	5	751	c.414delC	c.(412-414)CTCfs	p.L138fs	DTX3_uc001sov.1_Frame_Shift_Del_p.L131fs|DTX3_uc001sox.1_Frame_Shift_Del_p.L131fs|DTX3_uc001soy.1_Frame_Shift_Del_p.L131fs|GEFT_uc009zpy.2_5'Flank	NM_178502	NP_848597	Q8N9I9	DTX3_HUMAN	deltex homolog 3	138	Pro-rich.				Notch signaling pathway	cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					CTCGGGGGctcccccctcctc	0.537													4	9	---	---	---	---						.
AVPR1A	552	broad.mit.edu	37	12	63544421	63544421	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:63544421delC	uc001sro.1	-	1	2170	c.196delG	c.(196-198)GTGfs	p.V66fs		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	66	Helical; Name=1; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	TTGCCCAGCACGGCCACCGCG	0.687													25	32	---	---	---	---						.
WIF1	11197	broad.mit.edu	37	12	65514287	65514287	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:65514287delA	uc001ssk.2	-	2	343	c.198delT	c.(196-198)TTTfs	p.F66fs		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	66	WIF.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		AATCATGTGTAAAAGGTGCCA	0.383			T	HMGA2	pleomorphic salivary gland adenoma								32	58	---	---	---	---						.
EEA1	8411	broad.mit.edu	37	12	93213103	93213103	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:93213103delT	uc001tck.2	-	14	1974	c.1709delA	c.(1708-1710)AACfs	p.N570fs		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	570	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						TAGTGTATGGTTTTTTTCTTG	0.299													38	54	---	---	---	---						.
TMEM116	89894	broad.mit.edu	37	12	112369427	112369427	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr12:112369427delA	uc001ttc.1	-	13	1392	c.736delT	c.(736-738)TGAfs	p.*246fs	TMEM116_uc001ttd.1_Frame_Shift_Del_p.*338fs|TMEM116_uc001tte.1_Frame_Shift_Del_p.*303fs|TMEM116_uc001ttf.1_Frame_Shift_Del_p.*246fs|TMEM116_uc001ttg.1_RNA|TMEM116_uc001tth.1_Frame_Shift_Del_p.*152fs	NM_138341	NP_612350	Q8NCL8	TM116_HUMAN	transmembrane protein 116	246						integral to membrane				ovary(1)	1						TTGTAGTTTCAAAAAATGGTA	0.393													41	43	---	---	---	---						.
ZMYM2	7750	broad.mit.edu	37	13	20657094	20657094	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:20657094delA	uc001umr.2	+	24	4040	c.3742delA	c.(3742-3744)AAAfs	p.K1248fs	ZMYM2_uc001ums.2_Frame_Shift_Del_p.K1248fs|ZMYM2_uc001umt.2_Frame_Shift_Del_p.K1248fs|ZMYM2_uc001umv.2_Frame_Shift_Del_p.K628fs|ZMYM2_uc001umw.2_Frame_Shift_Del_p.K701fs	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		TAGGCATTGGAAAAAAAATCC	0.363													22	35	---	---	---	---						.
C13orf33	84935	broad.mit.edu	37	13	31480852	31480852	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:31480852delG	uc001uth.3	+	1	541	c.200delG	c.(199-201)CGGfs	p.R67fs	uc001utg.1_Intron	NM_032849	NP_116238	Q5VYS4	CM033_HUMAN	hypothetical protein LOC84935	67											0		Lung SC(185;0.0281)		all cancers(112;0.00914)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.0559)|GBM - Glioblastoma multiforme(144;0.244)		gcggcggcgcgggggggcTTC	0.582													8	8	---	---	---	---						.
COG6	57511	broad.mit.edu	37	13	40273702	40273702	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:40273702delA	uc001uxh.2	+	13	1331	c.1231delA	c.(1231-1233)AAAfs	p.K411fs	COG6_uc001uxi.2_Frame_Shift_Del_p.K359fs|COG6_uc010acb.2_Frame_Shift_Del_p.K411fs	NM_020751	NP_065802	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6 isoform	411					protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		TTTGCTAAGCAAAAAAATATT	0.289													13	23	---	---	---	---						.
HTR2A	3356	broad.mit.edu	37	13	47469818	47469818	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:47469818delT	uc001vbq.2	-	1	358	c.224delA	c.(223-225)AACfs	p.N75fs	HTR2A_uc001vbr.2_Intron|HTR2A_uc010acr.2_Frame_Shift_Del_p.N75fs	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	75	Extracellular (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGCAGACCAGTTTTTTTCCTG	0.458													32	46	---	---	---	---						.
CAB39L	81617	broad.mit.edu	37	13	49933960	49933960	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:49933960delT	uc001vcw.2	-	4	783	c.285delA	c.(283-285)AAAfs	p.K95fs	CAB39L_uc001vcx.2_Frame_Shift_Del_p.K95fs|CAB39L_uc010adf.2_Frame_Shift_Del_p.K92fs	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	95					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		GGGTCACATCTTTTTTTCCCT	0.274													16	37	---	---	---	---						.
TBC1D4	9882	broad.mit.edu	37	13	75884248	75884248	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:75884248delA	uc001vjl.1	-	14	2770	c.2423delT	c.(2422-2424)CTCfs	p.L808fs	TBC1D4_uc010tht.1_Frame_Shift_Del_p.L18fs|TBC1D4_uc010thu.1_Frame_Shift_Del_p.L18fs|TBC1D4_uc010aer.2_Frame_Shift_Del_p.L800fs|TBC1D4_uc010aes.2_Frame_Shift_Del_p.L745fs	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	808						cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		GGTTGGAGAGAGGGGGGACAG	0.498													18	25	---	---	---	---						.
EDNRB	1910	broad.mit.edu	37	13	78475266	78475267	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:78475266_78475267insA	uc001vko.2	-	4	1135_1136	c.877_878insT	c.(877-879)TATfs	p.Y293fs	EDNRB_uc001vkq.1_Frame_Shift_Ins_p.Y293fs|uc001vkn.1_Intron|EDNRB_uc010aez.1_Frame_Shift_Ins_p.Y293fs|EDNRB_uc001vkp.1_Frame_Shift_Ins_p.Y376fs	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	293	Helical; Name=5; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CATTAGTGTATAAAAAAATGCA	0.342													30	46	---	---	---	---						.
DZIP1	22873	broad.mit.edu	37	13	96293910	96293910	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:96293910delT	uc001vmk.2	-	5	1088	c.236delA	c.(235-237)AAGfs	p.K79fs	DZIP1_uc001vml.2_Frame_Shift_Del_p.K79fs|DZIP1_uc001vmn.2_Frame_Shift_Del_p.K68fs	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	79					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			CCCCGCCACCTTGTCCACGTC	0.667													60	98	---	---	---	---						.
UGGT2	55757	broad.mit.edu	37	13	96511867	96511867	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:96511867delT	uc001vmt.2	-	33	3973	c.3803delA	c.(3802-3804)AATfs	p.N1268fs	UGGT2_uc001vms.2_5'Flank	NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1268	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TGAGAGATAATTTTTTAGCAA	0.269													28	45	---	---	---	---						.
GPR18	2841	broad.mit.edu	37	13	99908125	99908126	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr13:99908125_99908126insT	uc001voe.3	-	3	502_503	c.1_2insA	c.(1-3)ATGfs	p.M1fs	UBAC2_uc001voa.3_Intron|UBAC2_uc010tiu.1_Intron|UBAC2_uc001vob.3_Intron|UBAC2_uc010tiv.1_Intron|UBAC2_uc001vod.2_Intron|UBAC2_uc001voc.2_Intron|UBAC2_uc010tiw.1_Intron|GPR18_uc010afv.2_Frame_Shift_Ins_p.M1fs	NM_005292	NP_005283	Q14330	GPR18_HUMAN	G protein-coupled receptor 18	1	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	CAGGGTGATCATTTTACAGCTT	0.327													57	110	---	---	---	---						.
TEP1	7011	broad.mit.edu	37	14	20852773	20852773	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:20852773delC	uc001vxe.2	-	22	3247	c.3207delG	c.(3205-3207)GGGfs	p.G1069fs	TEP1_uc010ahk.2_Frame_Shift_Del_p.G419fs|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Frame_Shift_Del_p.G961fs|TEP1_uc010tlh.1_5'Flank	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1069					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGCAGGTGATCCCTTTCTGTC	0.557													79	169	---	---	---	---						.
METT11D1	64745	broad.mit.edu	37	14	21462740	21462740	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:21462740delT	uc001vyn.2	+	8	933	c.736delT	c.(736-738)TTTfs	p.F246fs	METT11D1_uc001vym.2_Frame_Shift_Del_p.F246fs|METT11D1_uc001vyo.2_Frame_Shift_Del_p.F246fs|METT11D1_uc001vyp.2_Frame_Shift_Del_p.F88fs|METT11D1_uc001vyq.2_Frame_Shift_Del_p.F88fs	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	246					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TCCAGGTGTCTTTTTCAGACA	0.418													62	97	---	---	---	---						.
ZNF219	51222	broad.mit.edu	37	14	21561074	21561075	+	Frame_Shift_Del	DEL	GC	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:21561074_21561075delGC	uc001vzr.2	-	3	802_803	c.381_382delGC	c.(379-384)GCGCTAfs	p.A127fs	ZNF219_uc001vzs.2_Frame_Shift_Del_p.A127fs|ZNF219_uc010aik.1_Frame_Shift_Del_p.A127fs	NM_016423	NP_057507	Q9P2Y4	ZN219_HUMAN	zinc finger protein 219	127_128					negative regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|histamine receptor activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)	1	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;9.86e-11)|Epithelial(56;1.27e-08)|all cancers(55;6.06e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TCGCGTAGTAGCGCGCGCTCTT	0.708											OREG0022565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	30	---	---	---	---						.
SALL2	6297	broad.mit.edu	37	14	21992276	21992276	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:21992276delG	uc001wbe.2	-	2	1868	c.1586delC	c.(1585-1587)CCAfs	p.P529fs	SALL2_uc010tly.1_Frame_Shift_Del_p.P527fs|SALL2_uc010tlz.1_Frame_Shift_Del_p.P392fs|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Frame_Shift_Del_p.P394fs|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	529							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTCACTCCCTGGGGGGGTGTT	0.527													27	35	---	---	---	---						.
CBLN3	643866	broad.mit.edu	37	14	24898086	24898087	+	Frame_Shift_Ins	INS	-	C	C	rs147112147		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:24898086_24898087insC	uc001wpg.3	-	1	645_646	c.174_175insG	c.(172-177)GGGCCCfs	p.G58fs	KHNYN_uc010tpc.1_5'Flank|KHNYN_uc001wph.3_5'Flank|KHNYN_uc010alw.2_5'Flank	NM_001039771	NP_001034860	Q6UW01	CBLN3_HUMAN	cerebellin 3 precursor	58_59						cell junction|extracellular region|synapse		p.G58G(1)		central_nervous_system(1)	1				GBM - Glioblastoma multiforme(265;0.00159)		GCTCCCCCGGGCCCCCCTGCAG	0.723													4	6	---	---	---	---						.
AKAP6	9472	broad.mit.edu	37	14	33015029	33015029	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:33015029delA	uc001wrq.2	+	4	1340	c.1170delA	c.(1168-1170)CCAfs	p.P390fs	AKAP6_uc010aml.2_Frame_Shift_Del_p.P387fs	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	390					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CTACATTGCCAAAAAGAGGAC	0.418													40	75	---	---	---	---						.
AKAP6	9472	broad.mit.edu	37	14	33292703	33292703	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:33292703delA	uc001wrq.2	+	13	5854	c.5684delA	c.(5683-5685)GAAfs	p.E1895fs		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1895					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GCTGACATGGAAAATGGCAAT	0.353													22	45	---	---	---	---						.
ATL1	51062	broad.mit.edu	37	14	51089952	51089952	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:51089952delA	uc001wyf.3	+	11	1346	c.1105delA	c.(1105-1107)AAAfs	p.K369fs	ATL1_uc001wyd.3_Frame_Shift_Del_p.K369fs|ATL1_uc001wye.3_Frame_Shift_Del_p.K369fs	NM_015915	NP_056999	Q8WXF7	ATLA1_HUMAN	atlastin GTPase 1 isoform a	369	Cytoplasmic.				axonogenesis|cell death|endoplasmic reticulum organization|protein homooligomerization	axon|endoplasmic reticulum membrane|Golgi cis cisterna|Golgi membrane|integral to membrane|microsome	GTP binding|GTPase activity|identical protein binding			skin(3)|central_nervous_system(1)	4						CACATACAACAAAAAAATGGA	0.348													20	28	---	---	---	---						.
FERMT2	10979	broad.mit.edu	37	14	53360082	53360082	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:53360082delT	uc001xad.2	-	4	510	c.455delA	c.(454-456)AAGfs	p.K152fs	FERMT2_uc001xac.2_Frame_Shift_Del_p.K152fs|FERMT2_uc001xae.2_Frame_Shift_Del_p.K152fs|FERMT2_uc001xaf.2_Frame_Shift_Del_p.K152fs	NM_006832	NP_006823	Q96AC1	FERM2_HUMAN	fermitin family homolog 2 isoform 1	152					actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding				0	Breast(41;0.0342)					TAGCTTCTTCTTTTTTTTCTT	0.383													47	75	---	---	---	---						.
OTX2	5015	broad.mit.edu	37	14	57268921	57268921	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:57268921delG	uc001xcp.2	-	3	573	c.402delC	c.(400-402)CCCfs	p.P134fs	OTX2_uc010aou.2_Frame_Shift_Del_p.P134fs|OTX2_uc001xcq.2_Frame_Shift_Del_p.P142fs	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	134			P -> A (in MCOPS5).		axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					AGGTGCTAGAGGGGGGAGTGA	0.537													18	38	---	---	---	---						.
SIPA1L1	26037	broad.mit.edu	37	14	72090950	72090951	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:72090950_72090951insG	uc001xms.2	+	4	2163_2164	c.1815_1816insG	c.(1813-1818)CAAGGGfs	p.Q605fs	SIPA1L1_uc001xmt.2_Frame_Shift_Ins_p.Q605fs|SIPA1L1_uc001xmu.2_Frame_Shift_Ins_p.Q605fs|SIPA1L1_uc001xmv.2_Frame_Shift_Ins_p.Q605fs|SIPA1L1_uc010ttm.1_Frame_Shift_Ins_p.Q80fs	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	605_606					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TGGATGAACAAGGGGTGAGTTT	0.480													27	48	---	---	---	---						.
AHSA1	10598	broad.mit.edu	37	14	77935587	77935587	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:77935587delT	uc001xtw.2	+	9	1172	c.1012delT	c.(1012-1014)TTTfs	p.F338fs		NM_012111	NP_036243	O95433	AHSA1_HUMAN	activator of heat shock 90kDa protein ATPase	338					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding				0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		CGCACGCTTATTTTAGGGCCA	0.597													60	103	---	---	---	---						.
SERPINA11	256394	broad.mit.edu	37	14	94915004	94915004	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:94915004delG	uc001ydd.1	-	2	168	c.108delC	c.(106-108)CCCfs	p.P36fs		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	36					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		GCTGATGCCTGGGGGGTTGAG	0.567													68	131	---	---	---	---						.
ADAM6	8755	broad.mit.edu	37	14	107183650	107183650	+	RNA	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr14:107183650delC	uc010tyt.1	-	29		c.1907delG								Parts of antibodies, mostly variable regions.												0						GTCTCAGGGACCCCCCAGGCT	0.592													47	68	---	---	---	---						.
MTMR15	22909	broad.mit.edu	37	15	31196885	31196887	+	In_Frame_Del	DEL	CCT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:31196885_31196887delCCT	uc001zff.2	+	2	310_312	c.19_21delCCT	c.(19-21)CCTdel	p.P8del	MTMR15_uc001zfc.3_In_Frame_Del_p.P8del|MTMR15_uc010azw.2_In_Frame_Del_p.P8del|MTMR15_uc001zfd.3_In_Frame_Del_p.P8del|MTMR15_uc001zfe.2_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	8					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		AGAAGGGAAACCTCCTGACAAAA	0.340								Direct_reversal_of_damage|Editing_and_processing_nucleases					53	84	---	---	---	---						.
B2M	567	broad.mit.edu	37	15	45007689	45007690	+	Frame_Shift_Del	DEL	TA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:45007689_45007690delTA	uc001zuc.2	+	2	196_197	c.136_137delTA	c.(136-138)TATfs	p.Y46fs	B2M_uc010uek.1_Frame_Shift_Del_p.Y46fs|B2M_uc010bdx.1_Frame_Shift_Del_p.Y46fs	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	46	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		CCTGAATTGCTATGTGTCTGGG	0.401													62	97	---	---	---	---						.
B2M	567	broad.mit.edu	37	15	45007824	45007825	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:45007824_45007825insC	uc001zuc.2	+	2	331_332	c.271_272insC	c.(271-273)ACCfs	p.T91fs	B2M_uc010uek.1_Frame_Shift_Ins_p.T91fs|B2M_uc010bdx.1_Intron	NM_004048	NP_004039	P61769	B2MG_HUMAN	beta-2-microglobulin precursor	91	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			ovary(2)|skin(1)	3		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		CACTGAATTCACCCCCACTGAA	0.416													41	64	---	---	---	---						.
SLC24A5	283652	broad.mit.edu	37	15	48431210	48431211	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:48431210_48431211insT	uc001zwe.2	+	7	989_990	c.916_917insT	c.(916-918)ATTfs	p.I306fs	SLC24A5_uc010bel.2_Frame_Shift_Ins_p.I246fs|uc001zwf.1_5'Flank|SLC24A5_uc001zwk.2_5'Flank	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	306	Helical; Name=6; (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		CTTAAAAAGAATTTTTTGGGTA	0.312													32	45	---	---	---	---						.
RFX7	64864	broad.mit.edu	37	15	56386180	56386181	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:56386180_56386181insT	uc010bfn.2	-	9	3745_3746	c.3745_3746insA	c.(3745-3747)ATAfs	p.I1249fs	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Frame_Shift_Ins_p.I1063fs	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	1152					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						AACATTGGTTATTTTTTTACTG	0.416													26	54	---	---	---	---						.
GCNT3	9245	broad.mit.edu	37	15	59911278	59911280	+	In_Frame_Del	DEL	AAG	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:59911278_59911280delAAG	uc002age.2	+	3	1290_1292	c.841_843delAAG	c.(841-843)AAGdel	p.K283del	GCNT3_uc002agd.2_In_Frame_Del_p.K283del	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	283	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						CCTAACCAACAAGAAGAAGGATC	0.429													84	141	---	---	---	---						.
NARG2	79664	broad.mit.edu	37	15	60741266	60741267	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr15:60741266_60741267insT	uc002agp.2	-	10	2134_2135	c.1899_1900insA	c.(1897-1902)AAACCTfs	p.K633fs	NARG2_uc002ago.2_Frame_Shift_Ins_p.K496fs|NARG2_uc002agq.3_Frame_Shift_Ins_p.K301fs	NM_024611	NP_078887	Q659A1	NARG2_HUMAN	NMDA receptor regulated 2 isoform a	633_634						nucleus				ovary(1)|lung(1)	2						CGTTTGATAGGTTTTTTTAAAA	0.381													38	46	---	---	---	---						.
CACNA1H	8912	broad.mit.edu	37	16	1258148	1258148	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:1258148delC	uc002cks.2	+	16	3538	c.3290delC	c.(3289-3291)GCCfs	p.A1097fs	CACNA1H_uc002ckt.2_Frame_Shift_Del_p.A1097fs|CACNA1H_uc002cku.2_5'Flank|CACNA1H_uc010brj.2_5'Flank|CACNA1H_uc002ckv.2_5'Flank	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	1097	Cytoplasmic (Potential).				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CTGGATGCAGCCCCCAGCCTC	0.677													4	3	---	---	---	---						.
CLDN6	9074	broad.mit.edu	37	16	3065572	3065572	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:3065572delG	uc002csu.3	-	2	511	c.451delC	c.(451-453)CTGfs	p.L151fs		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	151	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TCAGCCACCAGGGGGTTATAG	0.627													12	18	---	---	---	---						.
KIAA0556	23247	broad.mit.edu	37	16	27761168	27761168	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:27761168delG	uc002dow.2	+	16	2911	c.2887delG	c.(2887-2889)GGGfs	p.G963fs		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	963										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						GACAGACGCTGGGGGTGACTT	0.582													13	27	---	---	---	---						.
SPN	6693	broad.mit.edu	37	16	29675364	29675365	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:29675364_29675365insC	uc002dtm.2	+	2	451_452	c.315_316insC	c.(313-318)GTGCCCfs	p.V105fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Frame_Shift_Ins_p.V105fs|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	105_106	Extracellular (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						TGTCATCAGTGCCCCAGGAAAC	0.515													32	67	---	---	---	---						.
CORO1A	11151	broad.mit.edu	37	16	30198155	30198155	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:30198155delG	uc002dww.2	+	4	462	c.340delG	c.(340-342)GGGfs	p.G114fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010vej.1_Frame_Shift_Del_p.G114fs|CORO1A_uc010bzq.2_Frame_Shift_Del_p.G114fs|CORO1A_uc010bzr.2_Frame_Shift_Del_p.G114fs|CORO1A_uc002dwx.2_Frame_Shift_Del_p.G8fs|CORO1A_uc002dwy.1_Translation_Start_Site|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	114					cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						GATCCCAGATGGGGGCCTGAT	0.652													16	33	---	---	---	---						.
FHOD1	29109	broad.mit.edu	37	16	67267852	67267853	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:67267852_67267853delGG	uc002esl.2	-	13	1865_1866	c.1753_1754delCC	c.(1753-1755)CCTfs	p.P585fs	FHOD1_uc010ced.2_Frame_Shift_Del_p.P392fs|FHOD1_uc010vjh.1_Frame_Shift_Del_p.P245fs	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	585	FH1.|Poly-Pro.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding	p.P585fs*43(1)		breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		AAGTGGGGGAGGGGGGGGTACT	0.624													7	16	---	---	---	---						.
ESRP2	80004	broad.mit.edu	37	16	68264452	68264452	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:68264452delG	uc010cfa.1	-	14	2122	c.1934delC	c.(1933-1935)CCAfs	p.P645fs	ESRP2_uc002evp.1_RNA|ESRP2_uc002evq.1_Frame_Shift_Del_p.P635fs	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	RNA binding motif protein 35B	645					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding|nucleotide binding			ovary(1)	1						GGGGGAGACTGGGGGGCTAGG	0.592													25	32	---	---	---	---						.
CHST4	10164	broad.mit.edu	37	16	71570593	71570593	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:71570593delA	uc002fan.2	+	2	194	c.13delA	c.(13-15)AAAfs	p.K5fs	CHST4_uc002fao.2_Frame_Shift_Del_p.K5fs	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	5	Cytoplasmic (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						GCTACTGCCTAAAAAAATGAA	0.463													56	87	---	---	---	---						.
ZFHX3	463	broad.mit.edu	37	16	72831391	72831392	+	In_Frame_Ins	INS	-	TGC	TGC	rs144937928		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr16:72831391_72831392insTGC	uc002fck.2	-	9	5862_5863	c.5189_5190insGCA	c.(5188-5190)CAA>CAGCAA	p.1730_1730Q>QQ	ZFHX3_uc002fcl.2_In_Frame_Ins_p.816_816Q>QQ	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1730	Poly-Gln.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				gttgttgctgttgctgctgctg	0.401													14	24	---	---	---	---						.
OR1A2	26189	broad.mit.edu	37	17	3101552	3101552	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:3101552delT	uc002fvd.1	+	1	740	c.740delT	c.(739-741)GTTfs	p.V247fs		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CTCACAGTTGTTTTTTTATAT	0.453													55	85	---	---	---	---						.
YBX2	51087	broad.mit.edu	37	17	7193758	7193758	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:7193758delG	uc002gfq.2	-	5	613	c.556delC	c.(556-558)CGGfs	p.R186fs		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	186	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GAGGGAGGCCGGGGGATGAAT	0.652													37	64	---	---	---	---						.
GPS2	2874	broad.mit.edu	37	17	7217257	7217258	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:7217257_7217258delCT	uc002gfv.1	-	5	710_711	c.447_448delAG	c.(445-450)AGAGCCfs	p.R149fs	GPS2_uc002gfw.1_Frame_Shift_Del_p.R111fs|GPS2_uc002gfx.1_Frame_Shift_Del_p.R149fs|NEURL4_uc002gfy.1_RNA|GPS2_uc002gfz.1_Frame_Shift_Del_p.R149fs	NM_004489	NP_004480	Q13227	GPS2_HUMAN	G protein pathway suppressor 2	149_150					cell cycle|inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter	transcriptional repressor complex	GTPase inhibitor activity|protein binding|transcription corepressor activity			ovary(2)|pancreas(1)	3		Prostate(122;0.157)				ATTTGTTTGGCTCTGTCAGCTG	0.530													71	109	---	---	---	---						.
MYOCD	93649	broad.mit.edu	37	17	12656041	12656041	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:12656041delC	uc002gnn.2	+	10	1735	c.1436delC	c.(1435-1437)TCCfs	p.S479fs	MYOCD_uc002gno.2_Frame_Shift_Del_p.S479fs|MYOCD_uc002gnp.1_Frame_Shift_Del_p.S383fs|MYOCD_uc002gnq.2_Frame_Shift_Del_p.S198fs	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	479	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AATGATGCCTCCCCCTCCTTC	0.627													27	61	---	---	---	---						.
MPRIP	23164	broad.mit.edu	37	17	17046886	17046886	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:17046886delC	uc002gqu.1	+	9	1108	c.1052delC	c.(1051-1053)GCCfs	p.A351fs	MPRIP_uc002gqv.1_Frame_Shift_Del_p.A351fs|MPRIP_uc002gqw.1_Intron	NM_201274	NP_958431	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase-Rho interacting protein	351	Interaction with F-actin (By similarity).					cytoplasm|cytoskeleton	actin binding				0						ACCAATGAAGCCCCCCCAGCT	0.652													13	26	---	---	---	---						.
ALDH3A2	224	broad.mit.edu	37	17	19566732	19566732	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:19566732delA	uc002gwb.1	+	7	1248	c.1027delA	c.(1027-1029)AAAfs	p.K343fs	ALDH3A2_uc002gwa.1_Frame_Shift_Del_p.K343fs|ALDH3A2_uc010cqr.1_Frame_Shift_Del_p.K150fs|ALDH3A2_uc002gwc.1_Frame_Shift_Del_p.K343fs|ALDH3A2_uc002gwd.1_Frame_Shift_Del_p.K150fs	NM_000382	NP_000373	P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3A2 isoform 2	343	Cytoplasmic.				cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase			ovary(2)	2	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	AGTGCCTGTGAAAAATGTAGA	0.363													41	57	---	---	---	---						.
MYO18A	399687	broad.mit.edu	37	17	27493332	27493332	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:27493332delG	uc002hdt.1	-	2	785	c.627delC	c.(625-627)CCCfs	p.P209fs	MYO18A_uc010csa.1_Frame_Shift_Del_p.P209fs|MYO18A_uc002hdu.1_Frame_Shift_Del_p.P209fs	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	209					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGGGCACCACGGGGGGCAGGC	0.662													42	56	---	---	---	---						.
LHX1	3975	broad.mit.edu	37	17	35300395	35300395	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:35300395delC	uc002hnh.1	+	5	2184	c.1188delC	c.(1186-1188)CACfs	p.H396fs		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	396					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				ACCTGTCCCACCCCCCCGAAA	0.597													10	23	---	---	---	---						.
HNF1B	6928	broad.mit.edu	37	17	36059174	36059174	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:36059174delG	uc002hok.3	-	8	1782	c.1561delC	c.(1561-1563)CAGfs	p.Q521fs	HNF1B_uc010wdi.1_Frame_Shift_Del_p.Q495fs	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	521					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TGGGAATACTGGGGGGGTTCC	0.517									Hereditary_Prostate_Cancer				23	37	---	---	---	---						.
WNK4	65266	broad.mit.edu	37	17	40939869	40939870	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:40939869_40939870insG	uc002ibj.2	+	8	1836_1837	c.1815_1816insG	c.(1813-1818)CCTGGGfs	p.P605fs	WNK4_uc010wgx.1_Frame_Shift_Ins_p.P269fs|WNK4_uc002ibk.1_Frame_Shift_Ins_p.P377fs|WNK4_uc010wgy.1_Intron	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	605_606					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTCAGCCCCCTGGGGGGGTGCC	0.634													39	41	---	---	---	---						.
TBX4	9496	broad.mit.edu	37	17	59560345	59560345	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:59560345delC	uc002izi.2	+	8	1151	c.1106delC	c.(1105-1107)TCCfs	p.S369fs	TBX4_uc010ddo.2_Frame_Shift_Del_p.S370fs|TBX4_uc010woy.1_Frame_Shift_Del_p.S370fs	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	369					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						TATTTCCGTTCCCCCCCTCCC	0.577													17	26	---	---	---	---						.
LRRC37A3	374819	broad.mit.edu	37	17	62856650	62856651	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:62856650_62856651insT	uc002jey.2	-	11	4144_4145	c.3613_3614insA	c.(3613-3615)AGGfs	p.R1205fs	LRRC37A3_uc010wqg.1_Frame_Shift_Ins_p.R323fs|LRRC37A3_uc002jex.1_Frame_Shift_Ins_p.R182fs|LRRC37A3_uc010wqf.1_Frame_Shift_Ins_p.R243fs|LRRC37A3_uc010dek.1_Frame_Shift_Ins_p.R211fs	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1205	Extracellular (Potential).					integral to membrane					0						ACTTCCGAGCCTTTTTTCTTCG	0.559													65	110	---	---	---	---						.
C17orf80	55028	broad.mit.edu	37	17	71233115	71233115	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:71233115delG	uc002jjm.3	+	3	1688	c.1494delG	c.(1492-1494)CAGfs	p.Q498fs	C17orf80_uc010wqu.1_Frame_Shift_Del_p.Q498fs|C17orf80_uc010dfj.2_Frame_Shift_Del_p.Q498fs|C17orf80_uc002jjk.1_Frame_Shift_Del_p.Q498fs|C17orf80_uc002jjl.3_Frame_Shift_Del_p.Q498fs	NM_017941	NP_060411	Q9BSJ5	CQ080_HUMAN	lung cancer-related protein 8 isoform a	498	Extracellular (Potential).					integral to membrane				skin(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			TCAGTCCCCAGGGGGAAAGAC	0.458													26	28	---	---	---	---						.
GALR2	8811	broad.mit.edu	37	17	74072797	74072797	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:74072797delG	uc002jqm.1	+	2	530	c.449delG	c.(448-450)TGGfs	p.W150fs	ZACN_uc002jqn.2_5'Flank|ZACN_uc002jqo.2_5'Flank|ZACN_uc010dgu.2_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	150	Helical; Name=4; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						GGGCTCATCTGGGGGCTGTCG	0.692													18	31	---	---	---	---						.
PRPSAP1	5635	broad.mit.edu	37	17	74328436	74328437	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:74328436_74328437insC	uc010wta.1	-	4	816_817	c.370_371insG	c.(370-372)GTCfs	p.V124fs	PRPSAP1_uc010wtb.1_Frame_Shift_Ins_p.V21fs	NM_002766	NP_002757	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate	95					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			ovary(1)	1						GTAGGGGATGACCCCAATAATG	0.495													51	88	---	---	---	---						.
USP36	57602	broad.mit.edu	37	17	76799940	76799942	+	In_Frame_Del	DEL	GGA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:76799940_76799942delGGA	uc002jvz.1	-	16	2660_2662	c.2335_2337delTCC	c.(2335-2337)TCCdel	p.S779del	USP36_uc002jwa.1_In_Frame_Del_p.S779del|USP36_uc002jwb.1_In_Frame_Del_p.S391del|USP36_uc002jwc.1_In_Frame_Del_p.S479del|USP36_uc002jvy.1_5'Flank	NM_025090	NP_079366	Q9P275	UBP36_HUMAN	ubiquitin specific peptidase 36	779					ubiquitin-dependent protein catabolic process	nucleolus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(99;0.000842)|OV - Ovarian serous cystadenocarcinoma(97;0.151)			CCGTCGAGATGGAGGAGCAGCTC	0.640													42	74	---	---	---	---						.
TBC1D16	125058	broad.mit.edu	37	17	77922699	77922699	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:77922699delC	uc002jxj.2	-	8	1629	c.1513delG	c.(1513-1515)GAAfs	p.E505fs	TBC1D16_uc002jxh.2_Frame_Shift_Del_p.E143fs|TBC1D16_uc002jxi.2_Frame_Shift_Del_p.E130fs|TBC1D16_uc002jxk.1_Frame_Shift_Del_p.E143fs	NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	505	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			GGATTGTCTTCCCCCCGGAAG	0.572													47	88	---	---	---	---						.
RNF213	57674	broad.mit.edu	37	17	78314019	78314019	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:78314019delC	uc002jyh.1	+	1	294	c.71delC	c.(70-72)ACCfs	p.T24fs		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GTCTTCGTCACCCCCCAGGCA	0.637													19	43	---	---	---	---						.
TSPAN10	83882	broad.mit.edu	37	17	79612444	79612445	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr17:79612444_79612445insT	uc010die.2	+	2	553_554	c.463_464insT	c.(463-465)GGGfs	p.G155fs	TSPAN10_uc002kaw.1_Frame_Shift_Ins_p.G155fs|TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10	155						integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			TGGCTTCTCTGGGGGCATCCTT	0.688													5	10	---	---	---	---						.
SPIRE1	56907	broad.mit.edu	37	18	12453139	12453140	+	Splice_Site	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:12453139_12453140insA	uc002kre.2	-	14	1824	c.1777_splice	c.e14-1	p.L593_splice	SPIRE1_uc002krc.2_Splice_Site|SPIRE1_uc010wzw.1_Splice_Site_p.L459_splice|SPIRE1_uc010wzx.1_Splice_Site_p.L382_splice|SPIRE1_uc010wzy.1_Splice_Site_p.L579_splice	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a							cytoskeleton|perinuclear region of cytoplasm	actin binding				0						AAAGCAGAGCTAAAAAATACAA	0.342													11	16	---	---	---	---						.
WBP11P1	441818	broad.mit.edu	37	18	30092428	30092428	+	RNA	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:30092428delC	uc010dmc.2	+	1		c.803delC				NR_003558				Homo sapiens cDNA clone IMAGE:5265376, partial cds.												0						CCCTGGTCCACCCCCTCCTCA	0.537													30	48	---	---	---	---						.
C18orf34	374864	broad.mit.edu	37	18	30926269	30926270	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:30926269_30926270insA	uc002kxn.2	-	8	705_706	c.563_564insT	c.(562-564)TTAfs	p.L188fs	C18orf34_uc010xbr.1_Frame_Shift_Ins_p.L188fs|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Frame_Shift_Ins_p.L188fs|C18orf34_uc002kxp.2_Frame_Shift_Ins_p.L188fs	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	188	Potential.									ovary(1)	1						TCTGTTGTTTTAAAGCTTCTTC	0.401													42	46	---	---	---	---						.
ZBTB7C	201501	broad.mit.edu	37	18	45567085	45567085	+	Frame_Shift_Del	DEL	C	-	-	rs115080210	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:45567085delC	uc002lda.2	-	1	410	c.394delG	c.(394-396)GACfs	p.D132fs	ZBTB7C_uc002ldb.2_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dnu.2_Frame_Shift_Del_p.D141fs|ZBTB7C_uc010dnv.2_Frame_Shift_Del_p.D154fs|ZBTB7C_uc010dnw.2_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dnx.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dny.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dnz.1_Frame_Shift_Del_p.D154fs|ZBTB7C_uc010dob.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010doc.1_Frame_Shift_Del_p.D141fs|ZBTB7C_uc010dod.1_Frame_Shift_Del_p.D154fs|ZBTB7C_uc010doe.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dof.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dog.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010doh.1_Frame_Shift_Del_p.D141fs|ZBTB7C_uc010doi.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010doj.1_Frame_Shift_Del_p.D141fs|ZBTB7C_uc010dok.1_Frame_Shift_Del_p.D181fs|ZBTB7C_uc010dol.1_Frame_Shift_Del_p.D141fs|ZBTB7C_uc010doa.1_Frame_Shift_Del_p.D154fs|ZBTB7C_uc010don.1_Frame_Shift_Del_p.D140fs|ZBTB7C_uc010doo.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dop.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010doq.1_Frame_Shift_Del_p.D141fs|ZBTB7C_uc010dor.1_Frame_Shift_Del_p.D154fs|ZBTB7C_uc010dos.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dot.1_Frame_Shift_Del_p.D132fs|ZBTB7C_uc010dou.1_Frame_Shift_Del_p.D141fs|ZBTB7C_uc010dom.1_Frame_Shift_Del_p.D141fs	NM_001039360	NP_001034449	A1YPR0	ZBT7C_HUMAN	zinc finger and BTB domain containing 7C	132	Glu-rich.|Asp-rich.					intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						tcccccccgtcccccCCAGGC	0.289													9	19	---	---	---	---						.
CDH7	1005	broad.mit.edu	37	18	63526952	63526953	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:63526952_63526953insA	uc002ljz.2	+	10	1828_1829	c.1503_1504insA	c.(1501-1506)CAGAAAfs	p.Q501fs	CDH7_uc002lka.2_Frame_Shift_Ins_p.Q501fs|CDH7_uc002lkb.2_Frame_Shift_Ins_p.Q501fs	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	501_502	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				AGGTTATCCAGAAAATCAGTGC	0.361													13	13	---	---	---	---						.
RTTN	25914	broad.mit.edu	37	18	67869206	67869207	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr18:67869206_67869207insT	uc002lkp.2	-	4	478_479	c.410_411insA	c.(409-411)AACfs	p.N137fs	RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Frame_Shift_Ins_p.N137fs	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	137							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				AGATTTCAGGGTTTTTTGACAA	0.356													19	33	---	---	---	---						.
SAFB2	9667	broad.mit.edu	37	19	5590343	5590343	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:5590343delC	uc002mcd.2	-	18	2683	c.2471delG	c.(2470-2472)GGCfs	p.G824fs		NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	824	Interacts with SAFB1.|Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		GGAGCCGTAGCCCCCCCAGCC	0.687													15	8	---	---	---	---						.
HSD11B1L	374875	broad.mit.edu	37	19	5687962	5687962	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:5687962delG	uc002mck.2	+	8	954	c.704delG	c.(703-705)CGGfs	p.R235fs	HSD11B1L_uc002mcu.2_3'UTR|HSD11B1L_uc002mcl.2_Frame_Shift_Del_p.R154fs|HSD11B1L_uc002mcm.2_3'UTR|HSD11B1L_uc002mcq.2_Frame_Shift_Del_p.R101fs|HSD11B1L_uc002mcr.2_3'UTR|HSD11B1L_uc002mcs.2_3'UTR|HSD11B1L_uc010dug.2_3'UTR|HSD11B1L_uc002mct.2_3'UTR|HSD11B1L_uc002mco.2_3'UTR|HSD11B1L_uc002mcn.2_3'UTR|HSD11B1L_uc002mcp.2_3'UTR|RPL36_uc002mcv.2_5'Flank|RPL36_uc002mcw.2_5'Flank	NM_198533	NP_940935	Q7Z5J1	DHI1L_HUMAN	short-chain dehydrogenase/reductase 10 isoform	235						extracellular region	binding|oxidoreductase activity				0						CCTGAGCACCGGGGGGTGCCC	0.682													5	1	---	---	---	---						.
SLC44A2	57153	broad.mit.edu	37	19	10753993	10753994	+	Frame_Shift_Ins	INS	-	TAAG	TAAG	rs17403917		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:10753993_10753994insTAAG	uc002mpf.2	+	22	2192_2193	c.2053_2054insTAAG	c.(2053-2055)CCTfs	p.P685fs	SLC44A2_uc002mpe.3_Frame_Shift_Ins_p.P683fs|SLC44A2_uc002mpg.1_3'UTR|SLC44A2_uc002mph.2_Frame_Shift_Ins_p.P234fs|SLC44A2_uc002mpi.2_3'UTR	NM_020428	NP_065161	Q8IWA5	CTL2_HUMAN	solute carrier family 44, member 2 isoform 1	685	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			ovary(1)	1			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	GGCCGAGAGGCCTTACTTCATG	0.604													24	14	---	---	---	---						.
NACC1	112939	broad.mit.edu	37	19	13248179	13248181	+	In_Frame_Del	DEL	CTT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:13248179_13248181delCTT	uc002mwm.2	+	4	1383_1385	c.1215_1217delCTT	c.(1213-1218)TCCTTC>TCC	p.F407del		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	407	BEN.				negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						TCCTGGCCTCCTTCTTTGACCGG	0.650													57	21	---	---	---	---						.
CACNA1A	773	broad.mit.edu	37	19	13395983	13395983	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:13395983delT	uc010dze.2	-	21	3830	c.3594delA	c.(3592-3594)AAAfs	p.K1198fs	CACNA1A_uc010dzc.2_Frame_Shift_Del_p.K723fs|CACNA1A_uc002mwy.3_Frame_Shift_Del_p.K1197fs|CACNA1A_uc010xne.1_Frame_Shift_Del_p.K726fs	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	1198	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	tctcttcctcttTTTTTGGCA	0.453													55	27	---	---	---	---						.
CPAMD8	27151	broad.mit.edu	37	19	17100545	17100545	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:17100545delC	uc002nfb.2	-	13	1476	c.1444delG	c.(1444-1446)GCTfs	p.A482fs		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	435						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AGGTACTGAGCCCCCACAGGC	0.592													16	32	---	---	---	---						.
KIAA0355	9710	broad.mit.edu	37	19	34833075	34833075	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:34833075delC	uc002nvd.3	+	10	3095	c.2236delC	c.(2236-2238)CCCfs	p.P746fs		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	746										ovary(1)	1	Esophageal squamous(110;0.162)					ACCGCAGCAGCCCCCGCCCCA	0.627													89	163	---	---	---	---						.
MLL4	9757	broad.mit.edu	37	19	36228635	36228635	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:36228635delG	uc010eei.2	+	35	7649	c.7649delG	c.(7648-7650)AGGfs	p.R2550fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2550					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTGCAGCTCAGGTCAACCAGG	0.597													2	4	---	---	---	---						.
CIC	23152	broad.mit.edu	37	19	42794441	42794441	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:42794441delC	uc002otf.1	+	10	1561	c.1521delC	c.(1519-1521)CGCfs	p.R507fs		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CCCACTGCCGCCCCCCACTGG	0.622			T	DUX4	soft tissue sarcoma								47	58	---	---	---	---						.
PPP1R13L	10848	broad.mit.edu	37	19	45900258	45900259	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:45900258_45900259insG	uc002pbn.2	-	4	333_334	c.256_257insC	c.(256-258)CGGfs	p.R86fs	PPP1R13L_uc002pbo.2_Frame_Shift_Ins_p.R86fs|PPP1R13L_uc002pbp.2_Frame_Shift_Ins_p.R86fs	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	86	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GGCCGCCTTCCGGGGGGACCCT	0.688													7	10	---	---	---	---						.
ZNF114	163071	broad.mit.edu	37	19	48789818	48789818	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:48789818delT	uc002pil.1	+	6	1434	c.937delT	c.(937-939)TTTfs	p.F313fs	ZNF114_uc010elv.1_Frame_Shift_Del_p.F313fs|ZNF114_uc002pim.1_Frame_Shift_Del_p.F313fs|ZNF114_uc002pin.2_Frame_Shift_Del_p.F279fs	NM_153608	NP_705836	Q8NC26	ZN114_HUMAN	zinc finger protein 114	313	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		TGGGAGAGCCTTTTTTTATCA	0.433													37	47	---	---	---	---						.
CYTH2	9266	broad.mit.edu	37	19	48981555	48981555	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:48981555delC	uc002pjj.3	+	11	1212	c.912delC	c.(910-912)ATCfs	p.I304fs	CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	304	PH.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GAGGAATCATCCCCCTGGAGA	0.448													47	49	---	---	---	---						.
SPHK2	56848	broad.mit.edu	37	19	49131530	49131530	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49131530delG	uc002pjr.2	+	6	1234	c.868delG	c.(868-870)GGGfs	p.G290fs	SPHK2_uc010xzt.1_Frame_Shift_Del_p.G231fs|SPHK2_uc002pjs.2_Frame_Shift_Del_p.G290fs|SPHK2_uc002pjt.2_Frame_Shift_Del_p.G84fs|SPHK2_uc002pju.2_Frame_Shift_Del_p.G254fs|SPHK2_uc002pjv.2_Frame_Shift_Del_p.G254fs|SPHK2_uc002pjw.2_Frame_Shift_Del_p.G352fs|SPHK2_uc010xzu.1_Frame_Shift_Del_p.G254fs	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	290	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		GAACCAGCACGGGGGGTAGGT	0.622													24	40	---	---	---	---						.
PPP1R15A	23645	broad.mit.edu	37	19	49377242	49377242	+	Frame_Shift_Del	DEL	G	-	-	rs557806	byFrequency	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49377242delG	uc002pky.3	+	2	1021	c.752delG	c.(751-753)CGAfs	p.R251fs		NM_014330	NP_055145	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	251	Glu-rich.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			lung(1)	1		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GTGTCCCCCCGATCTTCAGGC	0.547													29	49	---	---	---	---						.
CGB5	93659	broad.mit.edu	37	19	49548486	49548486	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49548486delC	uc002ply.2	+	3	798	c.433delC	c.(433-435)CCCfs	p.P145fs	CGB_uc010yad.1_Intron|CGB5_uc002plz.2_Frame_Shift_Del_p.P131fs	NM_033043	NP_149032	P01233	CGHB_HUMAN	chorionic gonadotropin, beta polypeptide 5	145					apoptosis|cell-cell signaling|cellular nitrogen compound metabolic process|female gamete generation|hormone biosynthetic process|peptide hormone processing|signal transduction	extracellular region|soluble fraction	hormone activity				0		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Choriogonadotropin alfa(DB00097)	AAAGGCCCCTCCCCCCAGCCT	0.632													9	17	---	---	---	---						.
SLC17A7	57030	broad.mit.edu	37	19	49933806	49933806	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:49933806delG	uc002pnp.2	-	12	1825	c.1653delC	c.(1651-1653)CCCfs	p.P551fs	SLC17A7_uc002pno.2_Frame_Shift_Del_p.P213fs	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	551	Cytoplasmic (Potential).|Pro-rich.				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GTGGGGGCCTGGGGGGCTGAA	0.642													11	25	---	---	---	---						.
TMEM86B	255043	broad.mit.edu	37	19	55739642	55739642	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:55739642delC	uc002qju.2	-	2	738	c.215delG	c.(214-216)GGCfs	p.G72fs	TMEM86B_uc002qjt.2_Frame_Shift_Del_p.G71fs	NM_173804	NP_776165	Q8N661	TM86B_HUMAN	transmembrane protein 86B	72					ether lipid metabolic process	cytoplasmic part|integral to membrane	alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		CTGGGTGTAGCCCCCGCTTGG	0.662													9	13	---	---	---	---						.
ZNF524	147807	broad.mit.edu	37	19	56113646	56113646	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr19:56113646delC	uc002qlk.1	+	2	251	c.168delC	c.(166-168)CGCfs	p.R56fs	FIZ1_uc002qli.3_5'Flank|FIZ1_uc002qlj.3_5'Flank	NM_153219	NP_694951	Q96C55	ZN524_HUMAN	zinc finger protein 524	56	A.T hook.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		AGCGGGGCCGCCCCCCCAAGT	0.692													6	2	---	---	---	---						.
FAM84A	151354	broad.mit.edu	37	2	14774272	14774273	+	Frame_Shift_Ins	INS	-	C	C	rs78327295		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:14774272_14774273insC	uc002rbz.1	+	2	411_412	c.169_170insC	c.(169-171)GCCfs	p.A57fs	FAM84A_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	57										pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			TGGCGTGAAGGCCCCCCCGGGT	0.634													20	23	---	---	---	---						.
ASXL2	55252	broad.mit.edu	37	2	25982513	25982513	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:25982513delT	uc002rgs.2	-	8	998	c.777delA	c.(775-777)AGAfs	p.R259fs	ASXL2_uc002rgt.1_5'UTR	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTTCATTTGTCCTACAAAAA	0.388													40	60	---	---	---	---						.
EMILIN1	11117	broad.mit.edu	37	2	27302078	27302079	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:27302078_27302079insC	uc002rii.3	+	1	573_574	c.145_146insC	c.(145-147)GCCfs	p.A49fs	EMILIN1_uc010eyq.1_Frame_Shift_Ins_p.A49fs	NM_007046	NP_008977	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1 precursor	49					cell adhesion	collagen				pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCCCAGATTGCCCCCCGGCCA	0.688													15	19	---	---	---	---						.
MPV17	4358	broad.mit.edu	37	2	27535561	27535563	+	In_Frame_Del	DEL	TCT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:27535561_27535563delTCT	uc002rjr.2	-	3	310_312	c.263_265delAGA	c.(262-267)AAGATG>ATG	p.K88del	MPV17_uc002rjq.2_In_Frame_Del_p.K88del|MPV17_uc002rjs.2_In_Frame_Del_p.K88del|MPV17_uc002rjt.2_RNA	NM_002437	NP_002428	P39210	MPV17_HUMAN	Mpv17 protein	88					cellular response to reactive oxygen species|glomerular basement membrane development|homeostatic process|inner ear development|mitochondrial genome maintenance|regulation of reactive oxygen species metabolic process	integral to peroxisomal membrane|mitochondrial inner membrane					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCAACAACATCTTCTTCAGTGC	0.522													36	50	---	---	---	---						.
SIX3	6496	broad.mit.edu	37	2	45169458	45169458	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:45169458delC	uc002run.1	+	1	422	c.215delC	c.(214-216)GCCfs	p.A72fs		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	72					visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ggcTCCAGGGCCCCCCCGGAA	0.353													7	15	---	---	---	---						.
FBXO11	80204	broad.mit.edu	37	2	48059584	48059585	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:48059584_48059585insG	uc010fbl.2	-	11	1163_1164	c.1049_1050insC	c.(1048-1050)GCTfs	p.A350fs	FBXO11_uc002rwe.2_Frame_Shift_Ins_p.A350fs|FBXO11_uc002rwf.2_Frame_Shift_Ins_p.A350fs|FBXO11_uc002rwg.1_Frame_Shift_Ins_p.A350fs|FBXO11_uc010fbk.2_5'UTR	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	434	PbH1 2.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCCAAATCCCAGCTAACGCATT	0.332													27	26	---	---	---	---						.
BCL11A	53335	broad.mit.edu	37	2	60688969	60688969	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:60688969delG	uc002sae.1	-	4	1306	c.1078delC	c.(1078-1080)CTCfs	p.L360fs	BCL11A_uc002sab.2_Frame_Shift_Del_p.L360fs|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Frame_Shift_Del_p.L326fs|BCL11A_uc002sad.1_Frame_Shift_Del_p.L208fs|BCL11A_uc002saf.1_Frame_Shift_Del_p.L326fs	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	360	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			AGAGGAGGGAGGGGGGGCGTC	0.632			T	IGH@	B-CLL								42	56	---	---	---	---						.
ATP6V1B1	525	broad.mit.edu	37	2	71191573	71191573	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:71191573delC	uc002shj.2	+	12	1236	c.1149delC	c.(1147-1149)TACfs	p.Y383fs	ATP6V1B1_uc010fdv.2_Frame_Shift_Del_p.Y366fs|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Frame_Shift_Del_p.Y341fs	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	383					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CTCAGATCTACCCCCCCATCA	0.547											OREG0014686	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	64	---	---	---	---						.
CTNNA2	1496	broad.mit.edu	37	2	80646692	80646693	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:80646692_80646693delAA	uc010ysh.1	+	8	1261_1262	c.1256_1257delAA	c.(1255-1257)CAAfs	p.Q419fs	CTNNA2_uc010yse.1_Frame_Shift_Del_p.Q419fs|CTNNA2_uc010ysf.1_Frame_Shift_Del_p.Q419fs|CTNNA2_uc010ysg.1_Frame_Shift_Del_p.Q419fs|CTNNA2_uc010ysi.1_Frame_Shift_Del_p.Q51fs	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	419					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						GAATATGCCCAAGTTTTCCGTG	0.446													24	53	---	---	---	---						.
IMMT	10989	broad.mit.edu	37	2	86400804	86400804	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:86400804delT	uc002sqz.3	-	4	778	c.390delA	c.(388-390)AAAfs	p.K130fs	IMMT_uc002sqy.3_5'Flank|IMMT_uc002srb.3_Frame_Shift_Del_p.K130fs|IMMT_uc002sra.3_Frame_Shift_Del_p.K130fs|IMMT_uc010ytd.1_Frame_Shift_Del_p.K130fs|IMMT_uc010yte.1_Frame_Shift_Del_p.K130fs|IMMT_uc002src.1_5'Flank|IMMT_uc002srd.2_Frame_Shift_Del_p.K130fs|IMMT_uc002sre.3_Frame_Shift_Del_p.K130fs|IMMT_uc010ytf.1_Frame_Shift_Del_p.K130fs|IMMT_uc010fgs.1_Frame_Shift_Del_p.K130fs	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	130	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						CTCCCTTTTGTTTTTGGAGTT	0.313													9	16	---	---	---	---						.
ANKRD20B	729171	broad.mit.edu	37	2	95483039	95483039	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:95483039delT	uc010fhq.1	-	1	508	c.116delA	c.(115-117)AATfs	p.N39fs	ANKRD20B_uc010fhp.2_RNA	NM_001012421	NP_001012421			ankyrin repeat domain 20 family, member A2												0						TTCTTCTCTATTTTTTTTGTA	0.274													8	0	---	---	---	---						.
ADRA2B	151	broad.mit.edu	37	2	96781111	96781111	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:96781111delC	uc002svi.2	-	1	778	c.778delG	c.(778-780)GAGfs	p.E260fs		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	260	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	TCAGGGGTCTCCCCCTCCTCC	0.637													17	22	---	---	---	---						.
PTPN4	5775	broad.mit.edu	37	2	120672766	120672767	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:120672766_120672767insA	uc002tmf.1	+	11	1547_1548	c.776_777insA	c.(775-777)GTAfs	p.V259fs	PTPN4_uc010flj.1_5'UTR	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	259	FERM.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	TTGAAGATTGTAAAAATTTCTT	0.218													20	36	---	---	---	---						.
TSN	7247	broad.mit.edu	37	2	122522936	122522936	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:122522936delA	uc002tnl.2	+	6	915	c.680delA	c.(679-681)GAAfs	p.E227fs	TSN_uc002tnm.2_Frame_Shift_Del_p.E180fs|TSN_uc010yze.1_3'UTR|TSN_uc010flt.2_RNA	NM_004622	NP_004613	Q15631	TSN_HUMAN	translin	227					DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding			breast(2)|large_intestine(1)	3		Ovarian(717;0.0563)|Prostate(154;0.116)				GCTTGTGTTGAAAAATAGGAG	0.512													24	49	---	---	---	---						.
NCKAP5	344148	broad.mit.edu	37	2	133751755	133751755	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:133751755delT	uc002ttp.2	-	7	773	c.399delA	c.(397-399)AAAfs	p.K133fs	NCKAP5_uc002ttq.2_Frame_Shift_Del_p.K133fs|NCKAP5_uc002tts.1_Frame_Shift_Del_p.K108fs	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	133	Potential.						protein binding				0						CAGTTTCTTCTTTTTTCTGCT	0.343													5	4	---	---	---	---						.
NOSTRIN	115677	broad.mit.edu	37	2	169699563	169699563	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:169699563delA	uc002ueg.2	+	8	570	c.566delA	c.(565-567)CAAfs	p.Q189fs	NOSTRIN_uc002uef.2_Frame_Shift_Del_p.Q189fs|NOSTRIN_uc002uei.2_Frame_Shift_Del_p.Q72fs|NOSTRIN_uc010fpu.2_Frame_Shift_Del_p.Q161fs|NOSTRIN_uc002ueh.2_Frame_Shift_Del_p.Q111fs|NOSTRIN_uc002uej.2_Frame_Shift_Del_p.Q72fs	NM_001039724	NP_001034813	Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficker isoform 2	189	Potential.				endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding				0						AATTACTACCAAAAAAACATG	0.333													18	29	---	---	---	---						.
Unknown	0	broad.mit.edu	37	2	186678578	186678578	+	RNA	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:186678578delT	uc002upm.2	+	2		c.3216delT			uc010zfu.1_Frame_Shift_Del_p.F1210fs					Homo sapiens cDNA FLJ44048 fis, clone TESTI4030669.																		CCTGAAAAAATTTTTGTCACT	0.373													41	70	---	---	---	---						.
BARD1	580	broad.mit.edu	37	2	215645975	215645975	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:215645975delT	uc002veu.2	-	4	758	c.623delA	c.(622-624)AAGfs	p.K208fs	BARD1_uc010zjm.1_Frame_Shift_Del_p.K64fs	NM_000465	NP_000456	Q99728	BARD1_HUMAN	BRCA1 associated RING domain 1	208					cell cycle arrest|DNA repair|negative regulation of apoptosis|negative regulation of mRNA 3'-end processing|negative regulation of protein export from nucleus|positive regulation of apoptosis|positive regulation of protein catabolic process|protein K6-linked ubiquitination|regulation of phosphorylation|tissue homeostasis	BRCA1-A complex|BRCA1-BARD1 complex|cytoplasm	kinase binding|protein heterodimerization activity|protein homodimerization activity|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)	2		Renal(323;0.0243)		Epithelial(149;3.2e-06)|all cancers(144;0.000461)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TAAAGTTTTCTTTTTTTGCTT	0.388									Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				28	42	---	---	---	---						.
ARPC2	10109	broad.mit.edu	37	2	219110150	219110152	+	In_Frame_Del	DEL	AAG	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:219110150_219110152delAAG	uc002vhd.2	+	8	669_671	c.557_559delAAG	c.(556-561)AAAGAA>AAA	p.E187del	ARPC2_uc002vhe.2_In_Frame_Del_p.E187del|ARPC2_uc002vhf.2_In_Frame_Del_p.E73del	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	187					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		CAGGAGTTCAAAGAAGGACGCAG	0.517													66	73	---	---	---	---						.
ZNF142	7701	broad.mit.edu	37	2	219508052	219508052	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:219508052delG	uc002vin.2	-	8	3623	c.3187delC	c.(3187-3189)CAGfs	p.Q1063fs	ZNF142_uc002vil.2_Frame_Shift_Del_p.Q1024fs|ZNF142_uc010fvt.2_Frame_Shift_Del_p.Q900fs|ZNF142_uc002vim.2_Frame_Shift_Del_p.Q900fs	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1063					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGCTGGGTCTGGGGGGTCCCT	0.607													19	36	---	---	---	---						.
TMEM198	130612	broad.mit.edu	37	2	220412523	220412523	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:220412523delG	uc002vme.2	+	4	1047	c.462delG	c.(460-462)CTGfs	p.L154fs	TMEM198_uc002vmf.2_Frame_Shift_Del_p.L154fs	NM_001005209	NP_001005209	Q66K66	TM198_HUMAN	transmembrane protein 198	154	Helical; (Potential).|Leu-rich.					integral to membrane				ovary(1)	1		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGCTGTTGCTGGGGGGCGGCC	0.721													14	31	---	---	---	---						.
IRS1	3667	broad.mit.edu	37	2	227660270	227660270	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr2:227660270delC	uc002voh.3	-	1	3237	c.3185delG	c.(3184-3186)GGCfs	p.G1062fs		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	1062					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		TCCTTGTGGGCCCCCCAGCAG	0.657													31	36	---	---	---	---						.
SIRPB1	10326	broad.mit.edu	37	20	1559235	1559235	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:1559235delG	uc010gai.2	-	2	281	c.182delC	c.(181-183)CCTfs	p.P61fs	SIRPB1_uc002wfk.3_Frame_Shift_Del_p.P61fs	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	61	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						GGGCCCCACAGGGATCAGGGA	0.537													34	22	---	---	---	---						.
TGM6	343641	broad.mit.edu	37	20	2384126	2384126	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:2384126delC	uc002wfy.1	+	8	1134	c.1073delC	c.(1072-1074)ACCfs	p.T358fs	TGM6_uc010gal.1_Frame_Shift_Del_p.T358fs	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	358					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CTGGATGCCACCCCCCAGGAG	0.582													30	67	---	---	---	---						.
DSTN	11034	broad.mit.edu	37	20	17581420	17581420	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:17581420delT	uc002wpr.2	+	2	296	c.41delT	c.(40-42)ATTfs	p.I14fs	DSTN_uc002wpq.2_5'UTR|DSTN_uc010gck.2_5'UTR	NM_006870	NP_006861	P60981	DEST_HUMAN	destrin isoform a	14	ADF-H.				actin filament severing|actin polymerization or depolymerization		actin binding			large_intestine(1)|skin(1)	2						GTATGTCGCATTTTTTATGAC	0.348													24	29	---	---	---	---						.
GZF1	64412	broad.mit.edu	37	20	23346169	23346171	+	In_Frame_Del	DEL	GAA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:23346169_23346171delGAA	uc010gdb.2	+	3	1323_1325	c.1149_1151delGAA	c.(1147-1152)GGGAAG>GGG	p.K385del	GZF1_uc002wsy.2_In_Frame_Del_p.K385del|GZF1_uc010zsq.1_Intron|GZF1_uc010zsr.1_Intron|GZF1_uc002wsz.2_In_Frame_Del_p.K385del	NM_022482	NP_071927	Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	385	C2H2-type 3.				transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			kidney(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					AGCTGTGCGGGAAGAAGTTCAAG	0.670													45	91	---	---	---	---						.
ADNP	23394	broad.mit.edu	37	20	49520470	49520470	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:49520470delT	uc002xvt.1	-	3	409	c.64delA	c.(64-66)ATAfs	p.I22fs	ADNP_uc002xvu.1_Frame_Shift_Del_p.I22fs	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	22						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TCACTAAGTATTTTTTTCACA	0.313													19	37	---	---	---	---						.
TAF4	6874	broad.mit.edu	37	20	60575303	60575303	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:60575303delT	uc002ybs.2	-	11	2664	c.2664delA	c.(2662-2664)AAAfs	p.K888fs		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	888					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TTATACCATGTTTTTTACCTA	0.353													48	73	---	---	---	---						.
DIDO1	11083	broad.mit.edu	37	20	61512527	61512528	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr20:61512527_61512528delTC	uc002ydr.1	-	16	5044_5045	c.4780_4781delGA	c.(4780-4782)GATfs	p.D1594fs	DIDO1_uc002yds.1_Frame_Shift_Del_p.D1594fs	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1594					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CCTGGAAGCATCTCTCTCGGGC	0.713													15	25	---	---	---	---						.
PIGP	51227	broad.mit.edu	37	21	38444815	38444815	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:38444815delT	uc002yvw.1	-	1	289	c.73delA	c.(73-75)ATGfs	p.M25fs	TTC3_uc002yvz.2_5'Flank|TTC3_uc011aee.1_5'Flank|PIGP_uc002yvy.1_RNA|PIGP_uc002yvx.1_Frame_Shift_Del_p.M1fs|TTC3_uc011aed.1_5'Flank|TTC3_uc010gne.1_5'Flank	NM_153681	NP_710148	P57054	PIGP_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	25					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity				0		Myeloproliferative disorder(46;0.0412)				TTTTCCACCATTTTTCCTGGG	0.488													113	155	---	---	---	---						.
MX1	4599	broad.mit.edu	37	21	42824678	42824680	+	In_Frame_Del	DEL	AGA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:42824678_42824680delAGA	uc002yzh.2	+	18	2587_2589	c.1640_1642delAGA	c.(1639-1644)GAGAAG>GAG	p.K548del	MX1_uc002yzi.2_In_Frame_Del_p.K548del|MX1_uc010goq.2_In_Frame_Del_p.K548del	NM_001144925	NP_001138397	P20591	MX1_HUMAN	myxovirus resistance protein 1	548					induction of apoptosis|response to virus|type I interferon-mediated signaling pathway	cytosol	GTP binding|GTPase activity|protein binding			ovary(1)	1		Prostate(19;3.18e-07)|all_epithelial(19;0.0277)				AAGGTCAGAGAGAAGGAGCTGGA	0.507													78	136	---	---	---	---						.
ZNF295	49854	broad.mit.edu	37	21	43413803	43413803	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr21:43413803delT	uc002zab.3	-	3	616	c.402delA	c.(400-402)AAAfs	p.K134fs	ZNF295_uc002yzz.3_Frame_Shift_Del_p.K134fs|ZNF295_uc002yzy.3_Frame_Shift_Del_p.K134fs|ZNF295_uc002zaa.3_Frame_Shift_Del_p.K134fs|ZNF295_uc010gov.1_Frame_Shift_Del_p.K134fs|ZNF295_uc002zac.2_Frame_Shift_Del_p.K134fs	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	134					negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTACAAACACTTTTTTTCTAT	0.378													24	34	---	---	---	---						.
CABIN1	23523	broad.mit.edu	37	22	24573647	24573647	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:24573647delC	uc002zzi.1	+	36	6508	c.6381delC	c.(6379-6381)CGCfs	p.R2127fs	CABIN1_uc002zzj.1_Frame_Shift_Del_p.R2048fs|CABIN1_uc002zzl.1_Frame_Shift_Del_p.R2127fs|CABIN1_uc010gul.1_Frame_Shift_Del_p.R65fs	NM_012295	NP_036427	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	2127	Required for interaction with calcineurin (By similarity).				cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						CTAAGTCCCGCCCCCTGCCCA	0.687													18	40	---	---	---	---						.
OSBP2	23762	broad.mit.edu	37	22	31289120	31289120	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:31289120delC	uc003aiy.1	+	9	1985	c.1881delC	c.(1879-1881)CACfs	p.H627fs	OSBP2_uc011ala.1_Frame_Shift_Del_p.H461fs|OSBP2_uc010gwc.1_Frame_Shift_Del_p.H454fs|OSBP2_uc011alb.1_Frame_Shift_Del_p.H578fs|OSBP2_uc003aiz.1_Frame_Shift_Del_p.H626fs|OSBP2_uc003aja.1_Frame_Shift_Del_p.H260fs|OSBP2_uc011alc.1_Frame_Shift_Del_p.H369fs|OSBP2_uc003ajb.2_Frame_Shift_Del_p.H172fs|OSBP2_uc011ald.1_Frame_Shift_Del_p.H171fs|OSBP2_uc010gwd.1_Frame_Shift_Del_p.H172fs	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	627					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						TGAGCCACCACCCCCCCTCAG	0.597													28	13	---	---	---	---						.
CBX6	23466	broad.mit.edu	37	22	39262729	39262729	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:39262729delG	uc003awl.2	-	5	787	c.724delC	c.(724-726)CTGfs	p.L242fs		NM_014292	NP_055107	O95503	CBX6_HUMAN	chromobox homolog 6	242					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex					0	Melanoma(58;0.04)					GGGGCTACCAGGGGGGCGGGC	0.687													27	51	---	---	---	---						.
POLDIP3	84271	broad.mit.edu	37	22	42988010	42988011	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:42988010_42988011insT	uc003bcu.2	-	7	1070_1071	c.971_972insA	c.(970-972)AAGfs	p.K324fs	POLDIP3_uc011app.1_Frame_Shift_Ins_p.K245fs|POLDIP3_uc003bcv.2_Frame_Shift_Ins_p.K295fs|POLDIP3_uc011apq.1_Frame_Shift_Ins_p.K341fs|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Intron	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	324	RRM.				positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						TGGCATCGTCCTTTTTCACAAA	0.540													113	54	---	---	---	---						.
EFCAB6	64800	broad.mit.edu	37	22	44004420	44004420	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:44004420delC	uc003bdy.1	-	22	2838	c.2623delG	c.(2623-2625)GCAfs	p.A875fs	EFCAB6_uc003bdz.1_Frame_Shift_Del_p.A723fs|EFCAB6_uc010gzi.1_Frame_Shift_Del_p.A723fs|EFCAB6_uc010gzj.1_Intron	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	875	EF-hand 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				CCGTACAGTGCGTTCTTTATG	0.433													31	50	---	---	---	---						.
TTLL8	164714	broad.mit.edu	37	22	50469119	50469120	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr22:50469119_50469120insG	uc011ark.1	-	12	1942_1943	c.1942_1943insC	c.(1942-1944)CTGfs	p.L648fs		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CAGCAAGGCCAGGGGGAGCCCC	0.703													7	2	---	---	---	---						.
SUMF1	285362	broad.mit.edu	37	3	4494631	4494631	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:4494631delA	uc003bpz.1	-	2	398	c.373delT	c.(373-375)TACfs	p.Y125fs	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Frame_Shift_Del_p.Y125fs|SUMF1_uc010hby.1_Frame_Shift_Del_p.Y125fs|SUMF1_uc011ast.1_Frame_Shift_Del_p.Y125fs	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	125						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		GCATCCATGTAAAAGGCATCA	0.458													38	54	---	---	---	---						.
IL17RC	84818	broad.mit.edu	37	3	9965696	9965696	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:9965696delA	uc003bua.2	+	8	1203	c.967delA	c.(967-969)AAAfs	p.K323fs	CIDEC_uc003bto.2_Intron|IL17RC_uc010hcr.2_RNA|IL17RC_uc011ato.1_RNA|IL17RC_uc010hcs.2_Frame_Shift_Del_p.K227fs|IL17RC_uc003btz.2_Frame_Shift_Del_p.K252fs|IL17RC_uc011atp.1_Frame_Shift_Del_p.K108fs|IL17RC_uc003bud.2_5'UTR|IL17RC_uc003bub.2_Frame_Shift_Del_p.K237fs|IL17RC_uc010hct.2_Frame_Shift_Del_p.K252fs|IL17RC_uc010hcu.2_Frame_Shift_Del_p.K252fs|IL17RC_uc010hcv.2_Frame_Shift_Del_p.K237fs|IL17RC_uc011atq.1_Frame_Shift_Del_p.K237fs|IL17RC_uc003buc.2_5'UTR	NM_153461	NP_703191	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C isoform 1 precursor	323	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)|pancreas(1)	2						CCGGTGGCACAAAAACCTGGT	0.572													40	60	---	---	---	---						.
VGLL4	9686	broad.mit.edu	37	3	11606282	11606282	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:11606282delC	uc003bwf.2	-	4	832	c.466delG	c.(466-468)GAGfs	p.E156fs	VGLL4_uc010hdx.1_Frame_Shift_Del_p.E162fs|VGLL4_uc003bwg.2_Frame_Shift_Del_p.E161fs|VGLL4_uc010hdv.1_Frame_Shift_Del_p.E72fs|VGLL4_uc010hdw.1_Frame_Shift_Del_p.E76fs|VGLL4_uc011aun.1_Frame_Shift_Del_p.E97fs	NM_014667	NP_055482	Q14135	VGLL4_HUMAN	vestigial like 4 isoform b	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		TGCTGCCGCTCCCCCGGGGTC	0.701													3	3	---	---	---	---						.
TRANK1	9881	broad.mit.edu	37	3	36897812	36897812	+	Frame_Shift_Del	DEL	T	-	-	rs11712950	by1000genomes	TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:36897812delT	uc003cgj.2	-	3	1921	c.1619delA	c.(1618-1620)GAGfs	p.E540fs		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1090	Glu-rich.				DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						ctcttcctcctcctcttcctc	0.433													7	3	---	---	---	---						.
ZNF619	285267	broad.mit.edu	37	3	40528461	40528461	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:40528461delA	uc011azb.1	+	6	858	c.580delA	c.(580-582)AAAfs	p.K194fs	ZNF619_uc010hhz.2_Frame_Shift_Del_p.K145fs|ZNF619_uc003ckj.2_Frame_Shift_Del_p.K138fs|ZNF619_uc011azc.1_Frame_Shift_Del_p.K154fs|ZNF619_uc011azd.1_Frame_Shift_Del_p.K110fs|ZNF619_uc011aza.1_Frame_Shift_Del_p.K96fs	NM_001145082	NP_001138554	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619 isoform 1	194					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TACAGGGAATAAAACAAAGAT	0.473													42	57	---	---	---	---						.
NBEAL2	23218	broad.mit.edu	37	3	47042816	47042816	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:47042816delC	uc003cqp.2	+	29	4711	c.4532delC	c.(4531-4533)GCCfs	p.A1511fs	NBEAL2_uc010hjm.1_Frame_Shift_Del_p.A888fs|NBEAL2_uc010hjn.1_5'Flank	NM_015175	NP_055990	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	1511							binding			ovary(1)	1		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		ATCAAAGAGGCCCCCGTGGGG	0.607													27	53	---	---	---	---						.
CELSR3	1951	broad.mit.edu	37	3	48699541	48699543	+	In_Frame_Del	DEL	AAA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:48699541_48699543delAAA	uc003cul.2	-	1	806_808	c.525_527delTTT	c.(523-528)TTTTTG>TTG	p.F175del	CELSR3_uc003cuf.1_In_Frame_Del_p.F245del	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	175	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTGCCGAATCAAAAAGTCTGAAG	0.645													42	97	---	---	---	---						.
IP6K2	51447	broad.mit.edu	37	3	48726979	48726980	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:48726979_48726980delCA	uc003cup.2	-	5	1015_1016	c.771_772delTG	c.(769-774)TGTGGCfs	p.C257fs	IP6K2_uc003cuq.2_Frame_Shift_Del_p.C257fs	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	257_258					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						ACCTGCATGCCACACACACGCA	0.525													31	56	---	---	---	---						.
PRKCD	5580	broad.mit.edu	37	3	53215749	53215752	+	Splice_Site	DEL	GTAA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:53215749_53215752delGTAA	uc003dgl.2	+	7	924	c.571_splice	c.e7+1	p.Q191_splice	PRKCD_uc003dgm.2_Splice_Site_p.Q191_splice|PRKCD_uc003dgn.2_Frame_Shift_Del_p.R191fs|PRKCD_uc010hmt.1_5'Flank	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta						activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AAATGCAGGCGTAAGTGTCTCCAC	0.574													31	27	---	---	---	---						.
ATXN7	6314	broad.mit.edu	37	3	63938154	63938156	+	In_Frame_Del	DEL	ATT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:63938154_63938156delATT	uc003dlw.3	+	5	1047_1049	c.494_496delATT	c.(493-498)CATTAT>CAT	p.Y166del	ATXN7_uc003dlv.2_In_Frame_Del_p.Y166del|ATXN7_uc010hnv.2_In_Frame_Del_p.Y166del	NM_000333	NP_000324	O15265	ATX7_HUMAN	ataxin 7 isoform a	166					cell death|histone deubiquitination|nucleus organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nuclear matrix|nucleolus	protein binding|zinc ion binding				0		Prostate(884;0.0181)		BRCA - Breast invasive adenocarcinoma(55;0.000614)|KIRC - Kidney renal clear cell carcinoma(15;0.00294)|Kidney(15;0.00305)		TTTCAATCACATTATGGTAAGTG	0.379													22	48	---	---	---	---						.
ARL13B	200894	broad.mit.edu	37	3	93761893	93761893	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:93761893delA	uc003drc.2	+	7	1119	c.833delA	c.(832-834)CAAfs	p.Q278fs	ARL13B_uc010hop.2_Frame_Shift_Del_p.Q129fs|ARL13B_uc003drd.2_Frame_Shift_Del_p.Q171fs|ARL13B_uc003dre.2_Frame_Shift_Del_p.Q263fs|ARL13B_uc003drf.2_Frame_Shift_Del_p.Q278fs|ARL13B_uc003drg.2_Frame_Shift_Del_p.Q175fs	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	278							GTP binding				0						AAAAAAAACCAAAAAATGGAG	0.328													14	18	---	---	---	---						.
ZBTB20	26137	broad.mit.edu	37	3	114058003	114058003	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:114058003delG	uc003ebi.2	-	5	2255	c.2075delC	c.(2074-2076)CCTfs	p.P692fs	ZBTB20_uc003ebj.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc010hqp.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebk.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebl.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebm.2_Frame_Shift_Del_p.P619fs|ZBTB20_uc003ebn.2_Frame_Shift_Del_p.P619fs	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	692					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGTGCCTGCAGGGGGGGTCCC	0.632													27	39	---	---	---	---						.
PLXNA1	5361	broad.mit.edu	37	3	126735391	126735391	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:126735391delC	uc003ejg.2	+	15	2981	c.2977delC	c.(2977-2979)CCCfs	p.P993fs		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1016	IPT/TIG 2.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GTGCCTGACACCCCCCGGGCA	0.627													32	69	---	---	---	---						.
ESYT3	83850	broad.mit.edu	37	3	138195072	138195072	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:138195072delT	uc003esk.2	+	21	2702	c.2476delT	c.(2476-2478)TTTfs	p.F826fs		NM_031913	NP_114119	A0FGR9	ESYT3_HUMAN	family with sequence similarity 62 (C2 domain	826	C2 3.					integral to membrane|plasma membrane					0						AAGATTTGAATTTTTTGTTCC	0.353													39	48	---	---	---	---						.
TRIM59	286827	broad.mit.edu	37	3	160155773	160155774	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:160155773_160155774insG	uc003fdm.2	-	3	1393_1394	c.1198_1199insC	c.(1198-1200)ATAfs	p.I400fs	IFT80_uc003fda.2_Intron	NM_173084	NP_775107	Q8IWR1	TRI59_HUMAN	tripartite motif-containing 59	400						integral to membrane|intracellular	zinc ion binding				0			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ATGGGAAACTATTTTCCACACA	0.337													18	30	---	---	---	---						.
EHHADH	1962	broad.mit.edu	37	3	184910086	184910086	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:184910086delT	uc003fpf.2	-	7	2127	c.2100delA	c.(2098-2100)AAAfs	p.K700fs	EHHADH_uc011brs.1_Frame_Shift_Del_p.K604fs	NM_001966	NP_001957	Q08426	ECHP_HUMAN	enoyl-Coenzyme A, hydratase/3-hydroxyacyl	700						peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			ovary(3)	3	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	GAGAAGCCAGTTTTTTTAGAT	0.463													27	62	---	---	---	---						.
PCYT1A	5130	broad.mit.edu	37	3	195966504	195966504	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr3:195966504delT	uc003fwg.2	-	9	984	c.811delA	c.(811-813)AGCfs	p.S271fs	uc003fwf.1_5'Flank|PCYT1A_uc003fwh.2_Frame_Shift_Del_p.S271fs	NM_005017	NP_005008	P49585	PCY1A_HUMAN	choline phosphate cytidylyltransferase 1 alpha	271	3 X 11 AA approximate tandem repeats.|Amphipathic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity				0	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	AGGTCAATGCTTTTTTCCTCC	0.423													22	38	---	---	---	---						.
KIAA1211	57482	broad.mit.edu	37	4	57179502	57179503	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:57179502_57179503insA	uc003hbk.2	+	7	885_886	c.494_495insA	c.(493-495)CCAfs	p.P165fs	KIAA1211_uc010iha.2_Frame_Shift_Ins_p.P158fs|KIAA1211_uc011bzz.1_Frame_Shift_Ins_p.P75fs|KIAA1211_uc003hbm.1_Frame_Shift_Ins_p.P51fs	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	165										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCTGTTAAGCCAAAAAAACAGA	0.569													29	64	---	---	---	---						.
PAICS	10606	broad.mit.edu	37	4	57307843	57307843	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:57307843delA	uc003hbs.1	+	3	262	c.31delA	c.(31-33)AAAfs	p.K11fs	PAICS_uc011cac.1_Frame_Shift_Del_p.K11fs|PAICS_uc003hbt.1_Frame_Shift_Del_p.K11fs|PAICS_uc003hbu.1_Frame_Shift_Del_p.K11fs|PAICS_uc010ihd.1_Frame_Shift_Del_p.K12fs	NM_006452	NP_006443	P22234	PUR6_HUMAN	phosphoribosylaminoimidazole carboxylase,	11	SAICAR synthetase.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|identical protein binding|phosphoribosylaminoimidazole carboxylase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Aspartic Acid(DB00128)	GAACATTGGTAAAAAATTATA	0.358													5	8	---	---	---	---						.
EPHA5	2044	broad.mit.edu	37	4	66467573	66467573	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:66467573delT	uc003hcy.2	-	3	889	c.696delA	c.(694-696)AAAfs	p.K232fs	EPHA5_uc003hcx.2_Frame_Shift_Del_p.K163fs|EPHA5_uc003hcz.2_Frame_Shift_Del_p.K232fs|EPHA5_uc011cah.1_Frame_Shift_Del_p.K232fs|EPHA5_uc011cai.1_Frame_Shift_Del_p.K232fs|EPHA5_uc003hda.2_Frame_Shift_Del_p.K232fs	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	232	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CAGAAGGGCATTTTTTATAGT	0.448										TSP Lung(17;0.13)			24	34	---	---	---	---						.
AMTN	401138	broad.mit.edu	37	4	71394929	71394930	+	Splice_Site	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:71394929_71394930insA	uc003hfk.1	+	7	446	c.357_splice	c.e7+2	p.L119_splice	AMTN_uc010ihy.1_Splice_Site_p.L118_splice	NM_212557	NP_997722	Q6UX39	AMTN_HUMAN	amelotin precursor						biomineral tissue development|cell adhesion|odontogenesis of dentine-containing tooth	basal lamina|cell-cell junction				large_intestine(1)|central_nervous_system(1)	2			Lung(101;0.235)			GAGGAATTGGTAAAAAAAATAA	0.267													6	12	---	---	---	---						.
CNOT6L	246175	broad.mit.edu	37	4	78697453	78697453	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:78697453delT	uc011ccd.1	-	2	230	c.99delA	c.(97-99)AAAfs	p.K33fs	CNOT6L_uc003hks.2_Frame_Shift_Del_p.K33fs|CNOT6L_uc011cce.1_Frame_Shift_Del_p.K33fs	NM_144571	NP_653172	Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	33					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			large_intestine(1)	1						CCCAGTGAGATTTTTTCCCAT	0.373													68	89	---	---	---	---						.
FRAS1	80144	broad.mit.edu	37	4	79410048	79410049	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:79410048_79410049insA	uc003hlb.2	+	59	9212_9213	c.8772_8773insA	c.(8770-8775)GCCAAGfs	p.A2924fs		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2919_2920	Calx-beta 4.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TGCAGTTTGCCAAGGATTTGCT	0.540													13	18	---	---	---	---						.
THAP9	79725	broad.mit.edu	37	4	83838382	83838382	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:83838382delT	uc003hnt.2	+	5	1136	c.1017delT	c.(1015-1017)TATfs	p.Y339fs	THAP9_uc003hns.1_Frame_Shift_Del_p.Y195fs|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Frame_Shift_Del_p.Y56fs	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	339							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				CTCTTGGTTATTTTTTTGTAA	0.413													54	98	---	---	---	---						.
HPGDS	27306	broad.mit.edu	37	4	95239029	95239029	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:95239029delT	uc003hte.1	-	3	312	c.221delA	c.(220-222)AACfs	p.N74fs		NM_014485	NP_055300	O60760	HPGDS_HUMAN	prostaglandin D2 synthase, hematopoietic	74	GST N-terminal.				locomotory behavior|prostaglandin biosynthetic process|signal transduction	cytoplasm|nucleus	calcium ion binding|glutathione transferase activity|magnesium ion binding|prostaglandin-D synthase activity|protein homodimerization activity			ovary(1)	1					Glutathione(DB00143)	GTTACCTGTGTTTTTGGTCAA	0.308													18	35	---	---	---	---						.
DAPP1	27071	broad.mit.edu	37	4	100789277	100789278	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:100789277_100789278insA	uc003hvf.3	+	9	868_869	c.778_779insA	c.(778-780)CAAfs	p.Q260fs	DAPP1_uc010ilh.2_3'UTR	NM_014395	NP_055210	Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and	260					signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity				0				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		ATTACAGTCACAAATAAGAAAA	0.396													42	64	---	---	---	---						.
BANK1	55024	broad.mit.edu	37	4	102951317	102951317	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:102951317delA	uc003hvy.3	+	10	2069	c.1795delA	c.(1795-1797)AAAfs	p.K599fs	BANK1_uc003hvx.3_Frame_Shift_Del_p.K584fs|BANK1_uc010ill.2_Frame_Shift_Del_p.K466fs|BANK1_uc003hvz.3_Frame_Shift_Del_p.K569fs	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	599					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		GAGTATAAAGAAAAAAACTGG	0.348													37	73	---	---	---	---						.
NHEDC1	150159	broad.mit.edu	37	4	103870465	103870465	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:103870465delT	uc003hww.2	-	4	453	c.331delA	c.(331-333)ATTfs	p.I111fs	NHEDC1_uc003hwu.2_Frame_Shift_Del_p.I111fs|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_Intron|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	111	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		AGTTGTAAAATTTTTCCCCCA	0.348													48	67	---	---	---	---						.
NDST4	64579	broad.mit.edu	37	4	115773883	115773884	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:115773883_115773884insT	uc003ibu.2	-	8	2492_2493	c.1813_1814insA	c.(1813-1815)ACAfs	p.T605fs	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	605	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.|PAPS (By similarity).					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATTTTTACCTGTTTTTTGTGGA	0.307													22	24	---	---	---	---						.
PCDH18	54510	broad.mit.edu	37	4	138452697	138452697	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:138452697delA	uc003ihe.3	-	1	933	c.546delT	c.(544-546)TTTfs	p.F182fs	PCDH18_uc003ihf.3_Frame_Shift_Del_p.F175fs|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_5'UTR|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	182	Extracellular (Potential).|Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					CCTCGATATTAAAAAAATCAT	0.493													26	33	---	---	---	---						.
FNIP2	57600	broad.mit.edu	37	4	159782570	159782571	+	Frame_Shift_Ins	INS	-	A	A	rs10004242		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:159782570_159782571insA	uc003iqe.3	+	11	1408_1409	c.1225_1226insA	c.(1225-1227)GAAfs	p.E409fs		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	409					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CGGCACTTTGGAAAAAAACCAG	0.406													20	30	---	---	---	---						.
ADAM29	11086	broad.mit.edu	37	4	175898771	175898771	+	Frame_Shift_Del	DEL	A	-	-	rs34732497		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:175898771delA	uc003iuc.2	+	5	2765	c.2095delA	c.(2095-2097)AAAfs	p.K699fs	ADAM29_uc003iud.2_Frame_Shift_Del_p.K699fs|ADAM29_uc010irr.2_Frame_Shift_Del_p.K699fs|ADAM29_uc011cki.1_Frame_Shift_Del_p.K699fs	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	699	Cytoplasmic (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TCGACTTTGTAAAAAAAGTAA	0.348													14	25	---	---	---	---						.
CCDC110	256309	broad.mit.edu	37	4	186379967	186379967	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr4:186379967delT	uc003ixu.3	-	6	1850	c.1774delA	c.(1774-1776)ACAfs	p.T592fs	CCDC110_uc003ixv.3_Frame_Shift_Del_p.T555fs|CCDC110_uc011ckt.1_Frame_Shift_Del_p.T592fs	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	592	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		AGCTGGTGTGTTTTTTTCTCT	0.303													16	31	---	---	---	---						.
PLK2	10769	broad.mit.edu	37	5	57753011	57753012	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:57753011_57753012insA	uc003jrn.2	-	7	1131_1132	c.1004_1005insT	c.(1003-1005)TTGfs	p.L335fs		NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	335					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		CACCAACCTGCAAAAAAAAGTC	0.411													17	36	---	---	---	---						.
RHOBTB3	22836	broad.mit.edu	37	5	95119656	95119656	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:95119656delA	uc003klm.2	+	10	2149	c.1612delA	c.(1612-1614)AAAfs	p.K538fs		NM_014899	NP_055714	O94955	RHBT3_HUMAN	rho-related BTB domain containing 3	538	Interaction with Rab9.				retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			lung(1)|skin(1)	2		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		TGACCTGCTTAAAAAGGCCAA	0.343													27	45	---	---	---	---						.
ZNF608	57507	broad.mit.edu	37	5	123983920	123983920	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:123983920delT	uc003ktq.1	-	4	2280	c.2157delA	c.(2155-2157)AAAfs	p.K719fs	ZNF608_uc003ktr.1_Intron|ZNF608_uc003kts.1_Frame_Shift_Del_p.K719fs|ZNF608_uc003ktt.1_Frame_Shift_Del_p.K719fs	NM_020747	NP_065798	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	719						intracellular	zinc ion binding			skin(3)|ovary(2)|lung(1)	6		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		AGTTGGTAGCTTTTTTGCCCT	0.498													24	31	---	---	---	---						.
RBM27	54439	broad.mit.edu	37	5	145647320	145647321	+	Frame_Shift_Del	DEL	AA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:145647320_145647321delAA	uc003lnz.3	+	15	2606_2607	c.2440_2441delAA	c.(2440-2442)AAAfs	p.K814fs	RBM27_uc003lny.2_Frame_Shift_Del_p.K759fs	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	814	Potential.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGAAGTGCTTAAAAAAAAACAG	0.347													34	60	---	---	---	---						.
SH3PXD2B	285590	broad.mit.edu	37	5	171785810	171785810	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:171785810delC	uc003mbr.2	-	8	805	c.634delG	c.(634-636)GTGfs	p.V212fs		NM_001017995	NP_001017995	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	212					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCATCCTGCACCCCATCCTGG	0.587													9	13	---	---	---	---						.
ZNF354B	117608	broad.mit.edu	37	5	178309869	178309869	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:178309869delA	uc003mjl.2	+	5	642	c.416delA	c.(415-417)GAAfs	p.E139fs	ZNF354B_uc003mjm.2_Frame_Shift_Del_p.E139fs	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GACAAAAATGAAAATTTACAA	0.328													28	24	---	---	---	---						.
TRIM52	84851	broad.mit.edu	37	5	180687359	180687361	+	In_Frame_Del	DEL	TTC	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr5:180687359_180687361delTTC	uc003mnp.2	-	1	759_761	c.454_456delGAA	c.(454-456)GAAdel	p.E152del	uc003mnq.2_5'Flank	NM_032765	NP_116154	Q96A61	TRI52_HUMAN	tripartite motif-containing 52	152	Glu-rich.					intracellular	zinc ion binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.0106)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0588)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.232)		CTTCCAGTATTTCTTCTTCTCGG	0.507													51	106	---	---	---	---						.
PRPF4B	8899	broad.mit.edu	37	6	4032686	4032687	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:4032686_4032687insA	uc003mvv.2	+	2	1026_1027	c.935_936insA	c.(934-936)AGAfs	p.R312fs	PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	312	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TCCAAAGAGAGAAAATCAAAAC	0.386													29	63	---	---	---	---						.
SNRNP48	154007	broad.mit.edu	37	6	7609096	7609096	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:7609096delA	uc003mxr.2	+	9	1069	c.1010delA	c.(1009-1011)CAAfs	p.Q337fs	SNRNP48_uc003mxs.2_RNA	NM_152551	NP_689764	Q6IEG0	SNR48_HUMAN	U11/U12 snRNP 48K	337					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding				0						AGAAGAAAGCAAAAAATATAA	0.289													14	10	---	---	---	---						.
HIVEP1	3096	broad.mit.edu	37	6	12089463	12089463	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:12089463delA	uc003nac.2	+	3	266	c.87delA	c.(85-87)TCAfs	p.S29fs		NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	29					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CAGAAGTTTCAAAAAAAGGTA	0.259													22	51	---	---	---	---						.
PHACTR1	221692	broad.mit.edu	37	6	13206135	13206135	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:13206135delG	uc010jpc.2	+	8	1085	c.753delG	c.(751-753)GTGfs	p.V251fs	PHACTR1_uc011dir.1_Frame_Shift_Del_p.V320fs|PHACTR1_uc003nag.1_Frame_Shift_Del_p.V251fs|PHACTR1_uc003nah.1_Frame_Shift_Del_p.V251fs	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	251						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GTATGCCCGTGGGGGGGCCAG	0.597													27	49	---	---	---	---						.
TCF19	6941	broad.mit.edu	37	6	31127312	31127312	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:31127312delC	uc003nss.2	+	2	590	c.66delC	c.(64-66)CACfs	p.H22fs	CCHCR1_uc011dne.1_5'Flank|CCHCR1_uc003nsq.3_5'Flank|CCHCR1_uc003nsp.3_5'Flank|CCHCR1_uc003nsr.3_5'Flank|CCHCR1_uc010jsk.1_5'Flank|TCF19_uc003nst.2_Frame_Shift_Del_p.H22fs	NM_001077511	NP_001070979	Q9Y242	TCF19_HUMAN	transcription factor 19	22					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACACCTTCCACCCCCCCGCCG	0.687													10	16	---	---	---	---						.
UNC5CL	222643	broad.mit.edu	37	6	41002639	41002639	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:41002639delG	uc003opi.2	-	2	264	c.175delC	c.(175-177)CAAfs	p.Q59fs	UNC5CL_uc010jxe.1_Frame_Shift_Del_p.Q59fs	NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	59	Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					TTTTCTAGTTGGGGGGTAGGC	0.582													37	77	---	---	---	---						.
CUL7	9820	broad.mit.edu	37	6	43018130	43018130	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:43018130delA	uc003otq.2	-	5	1543	c.1240delT	c.(1240-1242)TGGfs	p.W414fs	CUL7_uc011dvb.1_Frame_Shift_Del_p.W498fs|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	414	Interaction with TP53.				interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GTTGACTCCCAAAATACCTGG	0.532													20	40	---	---	---	---						.
SLC22A7	10864	broad.mit.edu	37	6	43271815	43271815	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:43271815delG	uc003out.2	+	10	1524	c.1425delG	c.(1423-1425)CTGfs	p.L475fs	SLC22A7_uc003ous.2_Frame_Shift_Del_p.L473fs	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	475	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			TGGGCCGGCTGGGGGGCTCTT	0.632													88	132	---	---	---	---						.
PLA2G7	7941	broad.mit.edu	37	6	46675819	46675820	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:46675819_46675820insA	uc010jzf.2	-	10	1217_1218	c.948_949insT	c.(946-951)TTTATCfs	p.F316fs	PLA2G7_uc010jzg.1_Intron	NM_005084	NP_005075	Q13093	PAFA_HUMAN	phospholipase A2, group VII	316_317					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding				0			Lung(136;0.192)			TCAGAGTTGATAAAAAAGAGGG	0.347													30	30	---	---	---	---						.
REV3L	5980	broad.mit.edu	37	6	111709248	111709248	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:111709248delA	uc003puy.3	-	8	1226	c.903delT	c.(901-903)TTTfs	p.F301fs	REV3L_uc003pux.3_Frame_Shift_Del_p.F223fs|REV3L_uc003puz.3_Frame_Shift_Del_p.F223fs	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	301					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTCTCTTCTGAAATTTTTTTT	0.284								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					33	43	---	---	---	---						.
FAM184A	79632	broad.mit.edu	37	6	119344234	119344234	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:119344234delT	uc003pyj.2	-	3	1374	c.1026delA	c.(1024-1026)AAAfs	p.K342fs	FAM184A_uc003pyk.3_Frame_Shift_Del_p.K222fs|FAM184A_uc003pyl.3_Frame_Shift_Del_p.K222fs	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	342	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						CATCAAGCTGTTTTTGAAGAA	0.368													38	71	---	---	---	---						.
THEMIS	387357	broad.mit.edu	37	6	128134568	128134568	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:128134568delT	uc003qbi.2	-	5	1537	c.1218delA	c.(1216-1218)AAAfs	p.K406fs	THEMIS_uc010kfa.2_Frame_Shift_Del_p.K309fs|THEMIS_uc011ebt.1_Frame_Shift_Del_p.K406fs|THEMIS_uc010kfb.2_Frame_Shift_Del_p.K371fs	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	406	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CATTCACCACTTTTTTTATTC	0.463													22	50	---	---	---	---						.
ARHGAP18	93663	broad.mit.edu	37	6	129921947	129921947	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:129921947delT	uc003qbr.2	-	11	1501	c.1412delA	c.(1411-1413)AATfs	p.N471fs	ARHGAP18_uc011ebw.1_Frame_Shift_Del_p.N471fs	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	471	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			ovary(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		TGTCATTTTATTTTTTTCTTT	0.343													23	49	---	---	---	---						.
HIVEP2	3097	broad.mit.edu	37	6	143094745	143094745	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:143094745delT	uc003qjd.2	-	5	1874	c.1131delA	c.(1129-1131)AAAfs	p.K377fs		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	377					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AATCTTGTCCTTTTTTCTCTG	0.433													75	102	---	---	---	---						.
SYNE1	23345	broad.mit.edu	37	6	152776589	152776590	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:152776589_152776590insC	uc010kiw.2	-	24	3465_3466	c.2863_2864insG	c.(2863-2865)GATfs	p.D955fs	SYNE1_uc003qot.3_Frame_Shift_Ins_p.D962fs|SYNE1_uc003qou.3_Frame_Shift_Ins_p.D955fs|SYNE1_uc010kjb.1_Frame_Shift_Ins_p.D938fs|SYNE1_uc003qow.2_Frame_Shift_Ins_p.D250fs|SYNE1_uc003qox.1_Frame_Shift_Ins_p.D471fs|SYNE1_uc003qoz.2_Frame_Shift_Ins_p.D387fs|SYNE1_uc003qoy.2_Frame_Shift_Ins_p.D522fs	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	955	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTCCTCTGGATCCCCCTTTTCC	0.510										HNSCC(10;0.0054)			31	52	---	---	---	---						.
ARID1B	57492	broad.mit.edu	37	6	157527817	157527817	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:157527817delC	uc003qqn.2	+	20	5640	c.5488delC	c.(5488-5490)CCCfs	p.P1830fs	ARID1B_uc003qqo.2_Frame_Shift_Del_p.P1790fs|ARID1B_uc003qqp.2_Frame_Shift_Del_p.P1777fs	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1835	Poly-Pro.				chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GCGCCCACCTCCCCCCTTAAG	0.552													39	60	---	---	---	---						.
IGF2R	3482	broad.mit.edu	37	6	160461692	160461694	+	In_Frame_Del	DEL	CCT	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:160461692_160461694delCCT	uc003qta.2	+	11	1564_1566	c.1416_1418delCCT	c.(1414-1419)GACCTC>GAC	p.L474del		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	474	Lumenal (Potential).|3.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AGAAGGAAGACCTCCTCTGCGGT	0.567													57	107	---	---	---	---						.
TTLL2	83887	broad.mit.edu	37	6	167754366	167754367	+	Frame_Shift_Ins	INS	-	T	T	rs150247166		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr6:167754366_167754367insT	uc003qvs.1	+	3	1066_1067	c.978_979insT	c.(976-981)AGATTTfs	p.R326fs	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	326_327	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CGCTCAGCAGATTTTTTTCCTA	0.446													74	131	---	---	---	---						.
C7orf50	84310	broad.mit.edu	37	7	1037311	1037311	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:1037311delG	uc003sju.2	-	5	605	c.535delC	c.(535-537)CTGfs	p.L179fs	C7orf50_uc003sjs.2_RNA|C7orf50_uc011jvt.1_Frame_Shift_Del_p.L179fs|C7orf50_uc011jvu.1_Frame_Shift_Del_p.L179fs	NM_032350	NP_115726	Q9BRJ6	CG050_HUMAN	hypothetical protein LOC84310	179							protein binding				0		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		CTCCCCGGCAGGGGGGGATCA	0.721													21	26	---	---	---	---						.
ETV1	2115	broad.mit.edu	37	7	13975472	13975473	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:13975472_13975473insG	uc011jxq.1	-	8	1153_1154	c.414_415insC	c.(412-417)CCCACAfs	p.P138fs	ETV1_uc011jxn.1_Frame_Shift_Ins_p.P98fs|ETV1_uc011jxo.1_Intron|ETV1_uc011jxp.1_Frame_Shift_Ins_p.P80fs|ETV1_uc003ssw.3_Frame_Shift_Ins_p.P138fs|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Frame_Shift_Ins_p.P120fs|ETV1_uc011jxs.1_Frame_Shift_Ins_p.P120fs|ETV1_uc010ktv.2_Frame_Shift_Ins_p.P7fs	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	138_139					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						CTGGATGGTGTGGGGGGGTTGG	0.530			T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								35	53	---	---	---	---						.
HOXA2	3199	broad.mit.edu	37	7	27140390	27140390	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:27140390delA	uc003syh.2	-	2	1361	c.1086delT	c.(1084-1086)TTTfs	p.F362fs		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	362						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GTGTGTCTGTAAAAAAGTCTA	0.438													60	102	---	---	---	---						.
ADCYAP1R1	117	broad.mit.edu	37	7	31104447	31104448	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:31104447_31104448insC	uc003tca.1	+	3	275_276	c.52_53insC	c.(52-54)GCCfs	p.A18fs	ADCYAP1R1_uc003tcb.1_Frame_Shift_Ins_p.A18fs|ADCYAP1R1_uc003tcc.1_Frame_Shift_Ins_p.A18fs|ADCYAP1R1_uc003tcd.1_Frame_Shift_Ins_p.A18fs|ADCYAP1R1_uc003tce.1_Frame_Shift_Ins_p.A18fs	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	18					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TCTCCTACAGGCCCCTGCCATG	0.569													9	15	---	---	---	---						.
MYO1G	64005	broad.mit.edu	37	7	45010276	45010276	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:45010276delG	uc003tmh.2	-	9	1276	c.1132delC	c.(1132-1134)CGGfs	p.R378fs	MYO1G_uc003tmf.2_5'Flank|MYO1G_uc003tmg.2_Frame_Shift_Del_p.R140fs|MYO1G_uc010kym.2_Frame_Shift_Del_p.R263fs|MYO1G_uc003tmi.1_Frame_Shift_Del_p.R290fs|MYO1G_uc003tmj.2_Frame_Shift_Del_p.R140fs	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	378	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						TCCCGGCCCCGGGGTTCCATG	0.607													51	79	---	---	---	---						.
ELN	2006	broad.mit.edu	37	7	73480300	73480300	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:73480300delG	uc003tzw.2	+	31	2168	c.2077delG	c.(2077-2079)GGGfs	p.G693fs	RFC2_uc011kfa.1_Intron|ELN_uc003tzn.2_Frame_Shift_Del_p.G687fs|ELN_uc003tzz.2_Frame_Shift_Del_p.G606fs|ELN_uc003tzo.2_Intron|ELN_uc003tzp.2_Intron|ELN_uc003tzq.2_Intron|ELN_uc003tzr.2_Intron|ELN_uc003tzs.2_Frame_Shift_Del_p.G668fs|ELN_uc003tzt.2_Intron|ELN_uc003tzu.2_Intron|ELN_uc003tzv.2_Intron|ELN_uc003tzx.2_Frame_Shift_Del_p.G677fs|ELN_uc011kff.1_Intron|ELN_uc003tzy.2_Frame_Shift_Del_p.G663fs	NM_000501	NP_001075224	P15502	ELN_HUMAN	elastin isoform a precursor	749					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			ovary(3)|pancreas(2)	5		Lung NSC(55;0.159)			Rofecoxib(DB00533)	AGGTGTCCTAGGGGGTGCCGG	0.617			T	PAX5	B-ALL		Supravalvular Aortic Stenosis|Cutis laxa |Williams-Beuren Syndrome						50	91	---	---	---	---						.
SEMA3E	9723	broad.mit.edu	37	7	83029431	83029431	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:83029431delT	uc003uhy.1	-	11	1745	c.1279delA	c.(1279-1281)ACAfs	p.T427fs		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	427	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				TTTCCATCTGTTTTTACCAAT	0.413													49	88	---	---	---	---						.
TSGA14	95681	broad.mit.edu	37	7	130052065	130052065	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:130052065delT	uc003vpz.2	-	4	209	c.162delA	c.(160-162)AAAfs	p.K54fs	TSGA14_uc010lmf.2_5'UTR|TSGA14_uc003vqa.2_Frame_Shift_Del_p.K54fs|TSGA14_uc011kpg.1_Frame_Shift_Del_p.K38fs	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	54					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					AAAGCTCATCTTTTTTGTATC	0.323													33	71	---	---	---	---						.
GIMAP8	155038	broad.mit.edu	37	7	150164231	150164232	+	Frame_Shift_Ins	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr7:150164231_150164232insA	uc003whj.2	+	2	775_776	c.445_446insA	c.(445-447)GAAfs	p.E149fs		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	149						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		AGATTTCATTGAAAAAAACAAA	0.450													30	50	---	---	---	---						.
PTK2B	2185	broad.mit.edu	37	8	27289871	27289871	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:27289871delC	uc003xfn.1	+	15	1788	c.980delC	c.(979-981)GCCfs	p.A327fs	PTK2B_uc003xfo.1_Frame_Shift_Del_p.A327fs|PTK2B_uc003xfp.1_Frame_Shift_Del_p.A327fs|PTK2B_uc003xfq.1_Frame_Shift_Del_p.A327fs|PTK2B_uc010luq.1_Frame_Shift_Del_p.A98fs|PTK2B_uc003xfr.1_Frame_Shift_Del_p.A73fs	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	327	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		ATTGAAGGTGCCCCCCAGGTG	0.607													18	41	---	---	---	---						.
FZD3	7976	broad.mit.edu	37	8	28409242	28409242	+	Frame_Shift_Del	DEL	T	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:28409242delT	uc003xgx.2	+	6	2005	c.1527delT	c.(1525-1527)AGTfs	p.S509fs	FZD3_uc010lvb.2_Frame_Shift_Del_p.S509fs	NM_017412	NP_059108	Q9NPG1	FZD3_HUMAN	frizzled 3 precursor	509	Cytoplasmic (Potential).				canonical Wnt receptor signaling pathway|cell proliferation in midbrain|commissural neuron axon guidance|establishment of planar polarity|facial nucleus development|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|neural tube closure|vasculature development	apical part of cell|axon|cytoplasm|dendrite|integral to membrane|neuron projection membrane|neuronal cell body|presynaptic active zone	G-protein coupled receptor activity|PDZ domain binding|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.109)|Kidney(114;0.13)|Colorectal(74;0.23)		AATGGGCCAGTTTTTTTCATG	0.353													46	94	---	---	---	---						.
UNC5D	137970	broad.mit.edu	37	8	35583896	35583897	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:35583896_35583897insC	uc003xjr.1	+	10	1858_1859	c.1530_1531insC	c.(1528-1533)TTTCCCfs	p.F510fs	UNC5D_uc003xjs.1_Frame_Shift_Ins_p.F505fs|UNC5D_uc003xju.1_Frame_Shift_Ins_p.F86fs|UNC5D_uc003xjt.1_Frame_Shift_Ins_p.F268fs	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	510_511	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCAGGACTTTTCCCCATGGAAA	0.470													35	79	---	---	---	---						.
TM7SF4	81501	broad.mit.edu	37	8	105360820	105360821	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:105360820_105360821insT	uc003ylx.1	+	2	89_90	c.40_41insT	c.(40-42)CTTfs	p.L14fs		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	14					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTTCCTAAGTCTTTGGGAGATT	0.460													41	86	---	---	---	---						.
DEPDC6	64798	broad.mit.edu	37	8	121013857	121013857	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr8:121013857delA	uc003yow.3	+	5	885	c.698delA	c.(697-699)GAAfs	p.E233fs	DEPDC6_uc011lid.1_Frame_Shift_Del_p.E132fs	NM_022783	NP_073620	Q8TB45	DPTOR_HUMAN	DEP domain containing 6	233					intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding				0	Lung NSC(37;9.35e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			CTGCTCAATGAAAAGTCCCCC	0.512													25	53	---	---	---	---						.
C9orf25	203259	broad.mit.edu	37	9	34401682	34401684	+	In_Frame_Del	DEL	GGA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:34401682_34401684delGGA	uc011lok.1	-	5	686_688	c.379_381delTCC	c.(379-381)TCCdel	p.S127del	C9orf25_uc003zuj.2_In_Frame_Del_p.S110del|C9orf25_uc003zuk.2_In_Frame_Del_p.S99del|C9orf25_uc011lol.1_In_Frame_Del_p.S116del|C9orf25_uc003zul.2_In_Frame_Del_p.S99del	NM_147202	NP_671735	Q8IW50	CI025_HUMAN	hypothetical protein LOC203259	127											0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.0858)		AGGAGTAGCCGGAGGAGGAGTAT	0.552													9	20	---	---	---	---						.
ARID3C	138715	broad.mit.edu	37	9	34625737	34625738	+	Splice_Site	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:34625737_34625738insC	uc011lon.1	-	2	391	c.391_splice	c.e2+1	p.G131_splice		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		CATGCCACTCACCCCTCTTTTG	0.550													39	58	---	---	---	---						.
KIAA1539	80256	broad.mit.edu	37	9	35107840	35107840	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:35107840delG	uc003zwl.2	-	3	757	c.432delC	c.(430-432)CCCfs	p.P144fs	KIAA1539_uc003zwm.2_Frame_Shift_Del_p.P144fs|KIAA1539_uc003zwn.2_Intron|KIAA1539_uc003zwo.2_Frame_Shift_Del_p.P144fs|KIAA1539_uc003zwp.1_Frame_Shift_Del_p.P144fs|KIAA1539_uc010mkk.1_Intron	NM_025182	NP_079458	Q7L5A3	K1539_HUMAN	hypothetical protein LOC80256	144						nucleus				ovary(2)	2	all_epithelial(49;0.217)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ATGGGGGGCAGGGGGGACTCC	0.617													36	57	---	---	---	---						.
TRPM6	140803	broad.mit.edu	37	9	77377518	77377518	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:77377518delA	uc004ajl.1	-	26	4307	c.4069delT	c.(4069-4071)TCAfs	p.S1357fs	TRPM6_uc004ajk.1_Frame_Shift_Del_p.S1352fs|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Frame_Shift_Del_p.S313fs	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1357	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GTTTCTGCTGAAAAAGGAACT	0.488													78	123	---	---	---	---						.
DAPK1	1612	broad.mit.edu	37	9	90321802	90321802	+	Frame_Shift_Del	DEL	G	-	-	rs56169226		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:90321802delG	uc004apc.2	+	26	3954	c.3816delG	c.(3814-3816)ATGfs	p.M1272fs	DAPK1_uc004apd.2_Frame_Shift_Del_p.M1272fs|DAPK1_uc011ltg.1_Frame_Shift_Del_p.M1206fs|DAPK1_uc011lth.1_Frame_Shift_Del_p.M1009fs|DAPK1_uc004apg.2_Frame_Shift_Del_p.M249fs	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	1272					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CCAACACCATGGGGGGGTACA	0.582									Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				25	41	---	---	---	---						.
FGD3	89846	broad.mit.edu	37	9	95738954	95738954	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:95738954delC	uc004asw.2	+	3	1044	c.416delC	c.(415-417)ACCfs	p.T139fs	FGD3_uc004asx.2_Frame_Shift_Del_p.T139fs|FGD3_uc004asz.2_Frame_Shift_Del_p.T139fs	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	139					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						TCTGAGAACACCCCCCAGAAG	0.662													11	16	---	---	---	---						.
ABCA1	19	broad.mit.edu	37	9	107548581	107548582	+	Frame_Shift_Ins	INS	-	T	T			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:107548581_107548582insT	uc004bcl.2	-	48	6711_6712	c.6398_6399insA	c.(6397-6399)AATfs	p.N2133fs	NIPSNAP3B_uc004bcj.1_Intron	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	2133	ABC transporter 2.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTATTACCTATTTTTTAGATG	0.381													33	67	---	---	---	---						.
FAM129B	64855	broad.mit.edu	37	9	130271374	130271374	+	Frame_Shift_Del	DEL	G	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:130271374delG	uc004brh.2	-	10	1400	c.1198delC	c.(1198-1200)CTGfs	p.L400fs	FAM129B_uc004bri.2_Frame_Shift_Del_p.L387fs|FAM129B_uc004brj.3_Frame_Shift_Del_p.L400fs	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	400							protein binding				0						TGCATCTTCAGGGGGTGGTAC	0.662													11	21	---	---	---	---						.
GTF3C5	9328	broad.mit.edu	37	9	135929331	135929332	+	Splice_Site	INS	-	A	A			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:135929331_135929332insA	uc004cci.3	+	6	1325	c.988_splice	c.e6+2	p.G330_splice	GTF3C5_uc010mzz.2_Splice_Site_p.G205_splice|GTF3C5_uc004ccj.3_Splice_Site_p.G330_splice	NM_012087	NP_036219	Q9Y5Q8	TF3C5_HUMAN	general transcription factor IIIC, polypeptide 5							transcription factor TFIIIC complex	DNA binding|protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;4.01e-06)|Epithelial(140;4e-05)		TGAAACACGGTAAAAATTCCTG	0.391													20	23	---	---	---	---						.
COL5A1	1289	broad.mit.edu	37	9	137703422	137703422	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:137703422delC	uc004cfe.2	+	46	4049	c.3667delC	c.(3667-3669)CCCfs	p.P1223fs		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1223	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CTTTCCTGGACCCCCTGGGCC	0.637											OREG0019605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	3	---	---	---	---						.
CAMSAP1	157922	broad.mit.edu	37	9	138703221	138703222	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:138703221_138703222delTG	uc004cgr.3	-	17	4742_4743	c.4742_4743delCA	c.(4741-4743)ACAfs	p.T1581fs	CAMSAP1_uc004cgq.3_Frame_Shift_Del_p.T1471fs|CAMSAP1_uc010nbg.2_Frame_Shift_Del_p.T1303fs	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	1581	CKK.					cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GGTTGTGGATTGTGAGTGCGTC	0.520													7	14	---	---	---	---						.
MIR602	693187	broad.mit.edu	37	9	140732961	140732961	+	RNA	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chr9:140732961delC	hsa-mir-602|MI0003615	+			c.91delC																				0						GAGAGCAGAGCCCCCCTGGCT	0.612													42	64	---	---	---	---						.
TXLNG	55787	broad.mit.edu	37	X	16850848	16850849	+	Frame_Shift_Ins	INS	-	AG	AG			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:16850848_16850849insAG	uc004cxq.1	+	6	1018_1019	c.967_968insAG	c.(967-969)CAGfs	p.Q323fs	TXLNG_uc010ney.1_Frame_Shift_Ins_p.Q191fs|TXLNG_uc004cxr.1_5'Flank	NM_018360	NP_060830	Q9NUQ3	TXLNG_HUMAN	gamma-taxilin	323	Potential.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane				lung(1)	1						TGAAAAACATCAGAGAGAGAGA	0.386													30	55	---	---	---	---						.
GPKOW	27238	broad.mit.edu	37	X	48972303	48972304	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:48972303_48972304insC	uc004dmr.2	-	8	1088_1089	c.1081_1082insG	c.(1081-1083)GACfs	p.D361fs		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	361						nucleus	nucleic acid binding			ovary(2)	2						CACACGCAGGTCCCTGTGCAAC	0.574													21	29	---	---	---	---						.
TEX13B	56156	broad.mit.edu	37	X	107224317	107224317	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:107224317delC	uc004enn.1	-	3	1025	c.932delG	c.(931-933)GGCfs	p.G311fs		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	311										ovary(1)	1						GCATCAGAGGCCCCCCAGTTG	0.562													64	108	---	---	---	---						.
ALG13	79868	broad.mit.edu	37	X	110970903	110970904	+	Frame_Shift_Ins	INS	-	C	C			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:110970903_110970904insC	uc011msy.1	+	18	2186_2187	c.2152_2153insC	c.(2152-2154)ACCfs	p.T718fs	ALG13_uc011msx.1_Frame_Shift_Ins_p.T614fs|ALG13_uc011msz.1_Frame_Shift_Ins_p.T640fs|ALG13_uc011mta.1_Frame_Shift_Ins_p.T614fs|ALG13_uc011mtb.1_Frame_Shift_Ins_p.T614fs			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	718					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						GTATGGATTTACCCCAGGGAAT	0.396													18	31	---	---	---	---						.
SLC6A14	11254	broad.mit.edu	37	X	115582694	115582694	+	Frame_Shift_Del	DEL	A	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:115582694delA	uc004eqi.2	+	8	1122	c.1018delA	c.(1018-1020)AAAfs	p.K340fs		NM_007231	NP_009162	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid	340					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			ovary(2)|pancreas(1)	3					L-Proline(DB00172)	CAATAAGTTCAAAAACAACTG	0.398													70	111	---	---	---	---						.
PGRMC1	10857	broad.mit.edu	37	X	118370513	118370513	+	Frame_Shift_Del	DEL	C	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:118370513delC	uc004erb.2	+	1	303	c.187delC	c.(187-189)CCCfs	p.P63fs	PGRMC1_uc011mts.1_Frame_Shift_Del_p.P63fs	NM_006667	NP_006658	O00264	PGRC1_HUMAN	progesterone receptor membrane component 1	63	Cytoplasmic (Potential).					cell surface|endoplasmic reticulum membrane|integral to membrane|microsome|nucleolus	heme binding|protein binding|receptor activity|steroid binding				0						CGACGAGCCGCCCCCTCTGCC	0.697													21	46	---	---	---	---						.
STAG2	10735	broad.mit.edu	37	X	123176474	123176475	+	Frame_Shift_Ins	INS	-	G	G			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:123176474_123176475insG	uc004etz.3	+	6	780_781	c.441_442insG	c.(439-444)AAAATGfs	p.K147fs	STAG2_uc004eua.2_Frame_Shift_Ins_p.K147fs|STAG2_uc004eub.2_Frame_Shift_Ins_p.K147fs|STAG2_uc004euc.2_Frame_Shift_Ins_p.K147fs|STAG2_uc004eud.2_Frame_Shift_Ins_p.K147fs|STAG2_uc004eue.2_Frame_Shift_Ins_p.K147fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	147_148					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TAATTCGAAAAATGACTGAAGA	0.292													34	44	---	---	---	---						.
BCORL1	63035	broad.mit.edu	37	X	129190011	129190011	+	Frame_Shift_Del	DEL	C	-	-	rs137862942		TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:129190011delC	uc004evb.1	+	13	5150	c.5036delC	c.(5035-5037)TCCfs	p.S1679fs	BCORL1_uc004evc.1_Frame_Shift_Del_p.S515fs	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1679					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GACGACAGATCCCCCCCAGGC	0.602													40	58	---	---	---	---						.
IDH3G	3421	broad.mit.edu	37	X	153053016	153053018	+	In_Frame_Del	DEL	TGA	-	-			TCGA-BR-A4QL-01A-31D-A25D-08	TCGA-BR-A4QL-10A-01D-A25E-08									Somatic	Phase_I	Capture				Illumina GAIIx	e4185ac3-7bc5-4881-a6fc-c72a990ce069	99b2d1f8-974a-4bcf-ad2d-84d93081945a	g.chrX:153053016_153053018delTGA	uc004fip.2	-	8	761_763	c.575_577delTCA	c.(574-579)ATCACC>ACC	p.I192del	IDH3G_uc004fio.2_In_Frame_Del_p.I134del|IDH3G_uc004fiq.2_In_Frame_Del_p.I192del|IDH3G_uc010num.2_In_Frame_Del_p.I134del|IDH3G_uc004fir.2_In_Frame_Del_p.I134del|IDH3G_uc004fit.1_In_Frame_Del_p.I192del|IDH3G_uc004fis.2_In_Frame_Del_p.I134del|IDH3G_uc004fiu.2_5'UTR	NM_004135	NP_004126	P51553	IDH3G_HUMAN	isocitrate dehydrogenase 3 (NAD+) gamma isoform	192					carbohydrate metabolic process|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleolus	ATP binding|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	TTGGCCTTGGTGATGATCTTCAG	0.586													14	24	---	---	---	---						.
