Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
WDR8	49856	broad.mit.edu	37	1	3553603	3553603	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:3553603C>T	uc001ako.2	-	5	580	c.472G>A	c.(472-474)GAT>AAT	p.D158N	WDR8_uc001akn.3_Missense_Mutation_p.D158N|WDR8_uc010nzi.1_Missense_Mutation_p.D158N	NM_017818	NP_060288	Q9P2S5	WRP73_HUMAN	WD repeat domain 8	158						centrosome	protein binding				0	all_cancers(77;0.0128)|all_epithelial(69;0.00526)|Ovarian(185;0.0634)|Lung NSC(156;0.162)|all_lung(157;0.172)	all_epithelial(116;7.37e-22)|all_lung(118;8.23e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;4.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.16e-22)|GBM - Glioblastoma multiforme(42;1.05e-14)|Colorectal(212;1.19e-05)|BRCA - Breast invasive adenocarcinoma(365;2.67e-05)|COAD - Colon adenocarcinoma(227;5.82e-05)|Kidney(185;0.000364)|KIRC - Kidney renal clear cell carcinoma(229;0.00223)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CTCACGTAATCTTTGCAGTCG	0.567000													4	19					0	0	0.009096	0	0	
TAS1R1	80835	broad.mit.edu	37	1	6631246	6631246	+	Missense_Mutation	SNP	G	A	A	rs139619592		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:6631246G>A	uc001ant.2	+	2	469	c.469G>A	c.(469-471)GCC>ACC	p.A157T	TAS1R1_uc001anu.2_Missense_Mutation_p.A157T|TAS1R1_uc001anv.2_Missense_Mutation_p.A157T|TAS1R1_uc001anw.2_Missense_Mutation_p.A157T	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	157	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CACCACAGCCGCCCTGCTGAG	0.607000													10	67					0	0	0.028581	0	0	
MIIP	60672	broad.mit.edu	37	1	12091346	12091346	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:12091346T>G	uc001ato.1	+	9	1146	c.966T>G	c.(964-966)ATT>ATG	p.I322M		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	322										ovary(1)	1						GCTGGGACATTTTTCCTCCGA	0.612000													6	50					0	0	0.021553	0	0	
VPS13D	55187	broad.mit.edu	37	1	12336474	12336474	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:12336474G>A	uc001atv.2	+	19	2970	c.2829G>A	c.(2827-2829)CAG>CAA	p.Q943Q	VPS13D_uc001atw.2_Silent_p.Q943Q|VPS13D_uc001atx.2_Silent_p.Q131Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	943					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGTTGGAGCAGCATACCCGCG	0.488000											OREG0013110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	95					0	0	0.004672	0	0	
VPS13D	55187	broad.mit.edu	37	1	12338075	12338075	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:12338075A>C	uc001atv.2	+	19	4571	c.4430A>C	c.(4429-4431)GAA>GCA	p.E1477A	VPS13D_uc001atw.2_Missense_Mutation_p.E1477A|VPS13D_uc001atx.2_Missense_Mutation_p.E665A	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	1477					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GATTTCTTTGAATCTTTGCAT	0.463000													19	130					0	0	0.012319	0	0	
PRAMEF4	400735	broad.mit.edu	37	1	12942969	12942969	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:12942969C>A	uc001aun.2	-	2	318	c.247G>T	c.(247-249)GTG>TTG	p.V83L		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	83										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCATCGAGCACAGCTTGGAAG	0.622000													12	75					6.40141e-05	6.58859e-05	0.010729	1	0	
SPEN	23013	broad.mit.edu	37	1	16255927	16255927	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:16255927A>T	uc001axk.1	+	11	3396	c.3192A>T	c.(3190-3192)AAA>AAT	p.K1064N	SPEN_uc010obp.1_Missense_Mutation_p.K1023N	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1064					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCAGCCCCAAAGACTGTCAGG	0.458000													4	116					0	0	0.009096	0	0	
KIF17	57576	broad.mit.edu	37	1	20998458	20998458	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:20998458C>T	uc001bdr.3	-	12	2813	c.2695G>A	c.(2695-2697)GTC>ATC	p.V899I	KIF17_uc001bdp.3_Missense_Mutation_p.V177I|KIF17_uc001bdq.3_Missense_Mutation_p.V177I|KIF17_uc009vpx.2_Missense_Mutation_p.V269I|KIF17_uc001bds.3_Missense_Mutation_p.V899I	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	899					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TTTGTGATGACGGGATGTGGG	0.577000													22	74					0	0	0.016522	0	0	
MAN1C1	57134	broad.mit.edu	37	1	26012981	26012981	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:26012981C>T	uc001bkm.2	+	2	921	c.591C>T	c.(589-591)AAC>AAT	p.N197N	MAN1C1_uc009vry.1_Silent_p.N17N	NM_020379	NP_065112	Q9NR34	MA1C1_HUMAN	mannosidase, alpha, class 1C, member 1	197	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(1)	1		Colorectal(325;3.78e-05)|Lung NSC(340;0.000181)|all_lung(284;0.000245)|Renal(390;0.000714)|Ovarian(437;0.00159)|Breast(348;0.0156)|Myeloproliferative disorder(586;0.0257)|all_neural(195;0.0515)|Esophageal squamous(538;0.232)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0574)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.15e-07)|COAD - Colon adenocarcinoma(152;4.31e-06)|STAD - Stomach adenocarcinoma(196;0.00125)|BRCA - Breast invasive adenocarcinoma(304;0.00141)|KIRC - Kidney renal clear cell carcinoma(1967;0.00146)|GBM - Glioblastoma multiforme(114;0.0149)|READ - Rectum adenocarcinoma(331;0.0803)		TGGGGAAAAACGAACTCCGTC	0.493000													5	180					0	0	0.021553	0	0	
YTHDF2	51441	broad.mit.edu	37	1	29069898	29069898	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:29069898A>C	uc001brc.2	+	4	1613	c.1116A>C	c.(1114-1116)GGA>GGC	p.G372G	YTHDF2_uc001brd.2_Silent_p.G369G|YTHDF2_uc010ofx.1_Silent_p.G322G|YTHDF2_uc001bre.2_Silent_p.G322G	NM_016258	NP_057342	Q9Y5A9	YTHD2_HUMAN	high glucose-regulated protein 8	372					humoral immune response					ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.000601)|all_lung(284;0.000771)|Breast(348;0.00502)|Renal(390;0.00758)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;5.46e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		ATGGAGTAGGACAGTCTCAGG	0.522000													29	163					0	0	0.027356	0	0	
CSMD2	114784	broad.mit.edu	37	1	33988919	33988919	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:33988919A>C	uc001bxn.1	-	66	10094	c.10065T>G	c.(10063-10065)GCT>GCG	p.A3355A	CSMD2_uc001bxm.1_Silent_p.A3499A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3355	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGCCATCTAAAGCCCAGTGAT	0.468000													7	72					0	0	0.003080	0	0	
OSCP1	127700	broad.mit.edu	37	1	36888482	36888482	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:36888482T>C	uc001cap.2	-	7	748	c.666A>G	c.(664-666)AAA>AAG	p.K222K	OSCP1_uc001caq.2_Silent_p.K212K	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	222					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTTCTTCACCTTTGTTGTTGA	0.398000													6	98					0	0	0.003080	0	0	
MACF1	23499	broad.mit.edu	37	1	39798125	39798125	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:39798125C>T	uc010oiu.1	+	1	1316	c.1185C>T	c.(1183-1185)GCC>GCT	p.A395A	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1960					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACCCTAAGGCCACAGCAAGCC	0.468000													17	91					0	0	0.004990	0	0	
PIK3R3	8503	broad.mit.edu	37	1	46511630	46511630	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:46511630G>A	uc001cpb.3	-	9	1903	c.1147C>T	c.(1147-1149)CGT>TGT	p.R383C	PIK3R3_uc009vyb.2_Missense_Mutation_p.R324C|PIK3R3_uc009vyc.2_Missense_Mutation_p.R400C|PIK3R3_uc001cpc.3_Missense_Mutation_p.R383C|PIK3R3_uc010olw.1_Missense_Mutation_p.R429C|PIK3R3_uc010olv.1_Missense_Mutation_p.R173C	NM_003629	NP_003620	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3	383	SH2 2.				insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding				0	Acute lymphoblastic leukemia(166;0.155)					CTACTCTCACGAATTAAGAAT	0.393000													31	242					0	0	0.012213	0	0	
CYP4A11	1579	broad.mit.edu	37	1	47403681	47403681	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:47403681A>G	uc001cqp.3	-	2	375	c.324T>C	c.(322-324)ATT>ATC	p.I108I	CYP4A11_uc001cqq.2_Silent_p.I108I|CYP4A11_uc010omm.1_RNA	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	108					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	ATCTCCCCAGAATCACCTTCA	0.502000													4	147					0	0	0.014758	0	0	
C1orf168	199920	broad.mit.edu	37	1	57257967	57257967	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:57257967T>C	uc001cym.3	-	2	925	c.519A>G	c.(517-519)AAA>AAG	p.K173K	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Silent_p.K173K	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	173										ovary(3)|skin(2)	5						GCCCCATGCCTTTTTGCCCTT	0.493000													3	212					0	0	0.004672	0	0	
CACHD1	57685	broad.mit.edu	37	1	65146982	65146982	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:65146982G>A	uc001dbo.1	+	25	3400	c.3295G>A	c.(3295-3297)GAA>AAA	p.E1099K	CACHD1_uc001dbp.1_Missense_Mutation_p.E854K|CACHD1_uc001dbq.1_Missense_Mutation_p.E854K|CACHD1_uc010opa.1_Missense_Mutation_p.E343K	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	1150	Cytoplasmic (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						TGACAGAGATGAAAGGGACGA	0.428000													11	91					0	0	0.010729	0	0	
IL12RB2	3595	broad.mit.edu	37	1	67793930	67793930	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:67793930T>G	uc001ddu.2	+	5	1167	c.527T>G	c.(526-528)ATT>AGT	p.I176S	IL12RB2_uc010oqi.1_Missense_Mutation_p.I176S|IL12RB2_uc010oqj.1_Missense_Mutation_p.I176S|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.I176S|IL12RB2_uc010oqm.1_Missense_Mutation_p.I176S|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	176	Extracellular (Potential).|Fibronectin type-III 1.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						TGTAAAGACATTTATTGTGAC	0.398000													7	303					0	0	0.006214	0	0	
LRRC7	57554	broad.mit.edu	37	1	70555444	70555444	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:70555444G>A	uc001dep.2	+	23	4403	c.4373G>A	c.(4372-4374)GGA>GAA	p.G1458E	LRRC7_uc009wbg.2_Missense_Mutation_p.G742E|LRRC7_uc001deq.2_Missense_Mutation_p.G652E	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1458	PDZ.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCTGGCCTTGGATTTAGTATC	0.289000													10	121					0	0	0.013537	0	0	
WDR63	126820	broad.mit.edu	37	1	85546958	85546958	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:85546958C>A	uc001dkt.2	+	4	336	c.145C>A	c.(145-147)CAA>AAA	p.Q49K	WDR63_uc009wcl.2_Missense_Mutation_p.Q49K	NM_145172	NP_660155	Q8IWG1	WDR63_HUMAN	WD repeat domain 63	49										upper_aerodigestive_tract(2)|ovary(2)|skin(1)	5				all cancers(265;0.00391)|Epithelial(280;0.00922)|Colorectal(170;0.166)		CACCAAGACCCAAGAAATATT	0.343000													12	137					1.61879e-10	1.70094e-10	0.013537	1	0	
COL24A1	255631	broad.mit.edu	37	1	86487966	86487966	+	Missense_Mutation	SNP	C	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:86487966C>G	uc001dlj.2	-	18	2255	c.2213G>C	c.(2212-2214)GGT>GCT	p.G738A	COL24A1_uc010osd.1_Missense_Mutation_p.G38A|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	738					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		TCCTGGTAAACCAACAGCACC	0.398000													13	79					0	0	0.013537	0	0	
LRRC8C	84230	broad.mit.edu	37	1	90178825	90178825	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:90178825A>T	uc001dnl.3	+	3	938	c.696A>T	c.(694-696)AAA>AAT	p.K232N		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	232						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		CTCTGGATAAAAAGGAAGGTG	0.448000													27	135					0	0	0.006320	0	0	
BRDT	676	broad.mit.edu	37	1	92442816	92442816	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:92442816A>G	uc001dok.3	+	6	1184	c.835A>G	c.(835-837)ATT>GTT	p.I279V	BRDT_uc001dol.3_Missense_Mutation_p.I279V|BRDT_uc010osz.1_Missense_Mutation_p.I283V|BRDT_uc009wdf.2_Missense_Mutation_p.I206V|BRDT_uc010ota.1_Missense_Mutation_p.I233V|BRDT_uc010otb.1_Missense_Mutation_p.I233V|BRDT_uc001dom.3_Missense_Mutation_p.I279V	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		CTGTAGTGAGATTCTTAAAGA	0.338000													16	155					0	0	0.028581	0	0	
AMY2B	280	broad.mit.edu	37	1	104115765	104115765	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:104115765T>G	uc001duq.2	+	5	1012	c.396T>G	c.(394-396)AGT>AGG	p.S132R	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.S132R|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	132					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		CCTGTGGAAGTTACTTCAACC	0.403000													81	630					0	0	0.014410	0	0	
AMY2B	280	broad.mit.edu	37	1	104117951	104117951	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:104117951A>G	uc001duq.2	+	8	1601	c.985A>G	c.(985-987)ACC>GCC	p.T329A	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.T329A|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	329					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		CTCTATTCTTACCTTCTGGGA	0.388000													10	411					0	0	0.013537	0	0	
AKNAD1	254268	broad.mit.edu	37	1	109394496	109394496	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:109394496A>C	uc001dwa.2	-	2	1060	c.791T>G	c.(790-792)ATT>AGT	p.I264S	AKNAD1_uc010ovb.1_Intron|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	264										ovary(3)	3						TTTGGGAGCAATCTTAGAGAA	0.398000													56	321					0	0	0.014410	0	0	
CAPZA1	829	broad.mit.edu	37	1	113212713	113212713	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:113212713A>G	uc001ecj.1	+	10	1212	c.820A>G	c.(820-822)ATA>GTA	p.I274V		NM_006135	NP_006126	P52907	CAZA1_HUMAN	F-actin capping protein alpha-1 subunit	274					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex|WASH complex	actin binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGAACAAGATACTCAGCTA	0.428000													4	113					0	0	0.009096	0	0	
LRIG2	9860	broad.mit.edu	37	1	113655213	113655213	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:113655213A>T	uc001edf.1	+	14	2109	c.1911A>T	c.(1909-1911)AAA>AAT	p.K637N	LRIG2_uc009wgn.1_Missense_Mutation_p.K534N	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	637	Ig-like C2-type 2.|Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CCTGGCAGAAAGATGGTGGTA	0.493000													17	202					0	0	0.007413	0	0	
TRIM45	80263	broad.mit.edu	37	1	117656011	117656011	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:117656011C>T	uc001egz.2	-	5	2152	c.1564G>A	c.(1564-1566)GCT>ACT	p.A522T	TRIM45_uc009whe.2_Missense_Mutation_p.A504T|TRIM45_uc001eha.2_Missense_Mutation_p.A418T	NM_025188	NP_079464	Q9H8W5	TRI45_HUMAN	tripartite motif-containing 45 isoform 1	522						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)	1	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		GCGCAGCGAGCGGTTTTCTGG	0.617000													7	98					0	0	0.001984	0	0	
ADAM30	11085	broad.mit.edu	37	1	120436891	120436891	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:120436891G>A	uc001eij.2	-	1	2223	c.2069C>T	c.(2068-2070)TCC>TTC	p.S690F		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	690	Helical; (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CATTATGATGGACACAACCCA	0.453000													4	138					0	0	0.014758	0	0	
SETDB1	9869	broad.mit.edu	37	1	150936034	150936034	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:150936034A>T	uc001evu.2	+	20	3676	c.3486A>T	c.(3484-3486)AAA>AAT	p.K1162N	SETDB1_uc001evv.2_Missense_Mutation_p.K1162N|SETDB1_uc009wmg.1_Missense_Mutation_p.K1162N	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1162	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGGCAGTAAAATCAACCCGAG	0.483000													15	369					0	0	0.004990	0	0	
POGZ	23126	broad.mit.edu	37	1	151378288	151378288	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:151378288A>C	uc001eyd.1	-	19	3529	c.3223T>G	c.(3223-3225)TTC>GTC	p.F1075V	POGZ_uc001eye.1_Missense_Mutation_p.F1022V|POGZ_uc010pdb.1_Missense_Mutation_p.F1066V|POGZ_uc001eyf.1_Missense_Mutation_p.F1031V|POGZ_uc010pdc.1_Missense_Mutation_p.F1013V|POGZ_uc009wmv.1_Missense_Mutation_p.F980V|POGZ_uc010pdd.1_Missense_Mutation_p.F566V	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	1075	HTH CENPB-type.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			ovary(3)	3	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CGCAGCATGAAACGCACAGCC	0.522000													11	113					0	0	0.008291	0	0	
FLG	2312	broad.mit.edu	37	1	152286342	152286342	+	Missense_Mutation	SNP	A	C	C	rs140261784	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:152286342A>C	uc001ezu.1	-	3	1056	c.1020T>G	c.(1018-1020)GAT>GAG	p.D340E	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	340	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTGTCTTCATCATGGGACC	0.562000									Ichthyosis				57	401					0	0	0.014410	0	0	
FLG2	388698	broad.mit.edu	37	1	152325738	152325738	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:152325738T>G	uc001ezw.3	-	3	4597	c.4524A>C	c.(4522-4524)GAA>GAC	p.E1508D	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1508	Filaggrin 5.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAGTGCACTTCACTGTCAC	0.502000													11	579					0	0	0.008291	0	0	
C1orf43	25912	broad.mit.edu	37	1	154180073	154180073	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:154180073T>C	uc001fei.2	-	7	1008	c.618A>G	c.(616-618)AAA>AAG	p.K206K	C1orf189_uc001fee.1_5'Flank|C1orf43_uc001fef.1_Silent_p.K103K|C1orf43_uc001feg.2_Silent_p.K172K|C1orf43_uc001feh.2_Silent_p.K154K|C1orf43_uc001fej.2_Silent_p.K188K|C1orf43_uc009wos.1_3'UTR	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	206						integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					GAGTTAGGTCTTTGGCTGCTG	0.502000													6	242					0	0	0.001984	0	0	
ADAR	103	broad.mit.edu	37	1	154574777	154574777	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:154574777C>T	uc001ffh.2	-	2	541	c.341G>A	c.(340-342)CGT>CAT	p.R114H	ADAR_uc001ffj.2_Missense_Mutation_p.R114H|ADAR_uc001ffi.2_Missense_Mutation_p.R114H|ADAR_uc001ffk.2_Translation_Start_Site|ADAR_uc001ffl.1_Translation_Start_Site|ADAR_uc001ffm.1_Intron|ADAR_uc001ffn.1_Intron	NM_001111	NP_001102	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific isoform a	114					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		ACTCCTGCCACGTGGTGAAGG	0.537000													20	111					0	0	0.010504	0	0	
PBXIP1	57326	broad.mit.edu	37	1	154919262	154919262	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:154919262A>C	uc001ffr.2	-	10	947	c.888T>G	c.(886-888)CTT>CTG	p.L296L	PBXIP1_uc001ffs.2_Silent_p.L267L|PBXIP1_uc010pep.1_Silent_p.L141L	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	296	Potential.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCAGGCTCTGAAGCTCTTCCT	0.552000													17	126					0	0	0.006122	0	0	
OR10Z1	128368	broad.mit.edu	37	1	158576882	158576882	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:158576882C>T	uc010pio.1	+	1	654	c.654C>T	c.(652-654)TAC>TAT	p.Y218Y		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	218	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					CCATCTCCTACGCCTACATCT	0.512000													29	273					0	0	0.007291	0	0	
SPTA1	6708	broad.mit.edu	37	1	158614075	158614075	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:158614075G>A	uc001fst.1	-	30	4505	c.4306C>T	c.(4306-4308)CGG>TGG	p.R1436W		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1436	Spectrin 14.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AAATCGTCCCGTTTCTTCATC	0.368000													9	134					0	0	0.010729	0	0	
OLFML2B	25903	broad.mit.edu	37	1	161968040	161968040	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:161968040G>T	uc001gbu.2	-	6	1473	c.1049C>A	c.(1048-1050)GCA>GAA	p.A350E	OLFML2B_uc010pkq.1_Missense_Mutation_p.A351E	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	350										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			ACGGGTGGCTGCAGGCCTCCG	0.587000													27	162					3.65163e-15	3.86578e-15	0.006320	1	0	
DUSP27	92235	broad.mit.edu	37	1	167096038	167096038	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:167096038A>T	uc001geb.1	+	5	1670	c.1670A>T	c.(1669-1671)CAC>CTC	p.H557L		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	557					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						TTTGGATTTCACAAGAAAGAC	0.552000													8	95					0	0	0.004482	0	0	
SELE	6401	broad.mit.edu	37	1	169694904	169694904	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:169694904T>C	uc001ggm.3	-	13	1971	c.1814A>G	c.(1813-1815)AAG>AGG	p.K605R	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	605	Cytoplasmic (Potential).				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					GTAAGAAGGCTTTTGGTAGCT	0.388000													15	129					0	0	0.028581	0	0	
C1orf156	92342	broad.mit.edu	37	1	169762022	169762022	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:169762022T>C	uc001ggn.2	-	2	1093	c.815A>G	c.(814-816)GAG>GGG	p.E272G	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank|C1orf112_uc009wvt.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	272						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CTTACAAAACTCAGACCACTC	0.323000													4	188					0	0	0.009096	0	0	
METTL13	51603	broad.mit.edu	37	1	171755119	171755119	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:171755119T>C	uc001ghz.2	+	3	1361	c.1014T>C	c.(1012-1014)CTT>CTC	p.L338L	METTL13_uc001gia.2_Silent_p.L252L|METTL13_uc001gib.2_Silent_p.L182L|METTL13_uc010pml.1_Silent_p.L337L	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	338							methyltransferase activity|protein binding			kidney(1)	1						CAGTGGCCCTTCACCGAGGTC	0.617000													5	33					0	0	0.014758	0	0	
SLC9A11	284525	broad.mit.edu	37	1	173570870	173570870	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:173570870A>C	uc001giz.2	-	2	469	c.46T>G	c.(46-48)TTA>GTA	p.L16V	SLC9A11_uc010pmq.1_Intron	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	16					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						CCGCAGAGTAAATCAGGTCTG	0.418000													43	265					0	0	0.009718	0	0	
TNN	63923	broad.mit.edu	37	1	175054550	175054550	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:175054550C>T	uc001gkl.1	+	6	1357	c.1244C>T	c.(1243-1245)CCG>CTG	p.P415L	TNN_uc010pmx.1_Missense_Mutation_p.P415L	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	415	Fibronectin type-III 2.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGTCTGCACCCGGGGACTGAG	0.602000													4	22					0	0	0.009096	0	0	
CEP350	9857	broad.mit.edu	37	1	180022921	180022921	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:180022921T>G	uc001gnt.2	+	24	5409	c.5026T>G	c.(5026-5028)TTT>GTT	p.F1676V	CEP350_uc009wxl.2_Missense_Mutation_p.F1675V	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1676						centrosome|nucleus|spindle				ovary(4)	4						ACAAGATAGCTTTTCTAAATT	0.398000													20	168					0	0	0.012319	0	0	
FAM5C	339479	broad.mit.edu	37	1	190129816	190129816	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:190129816A>C	uc001gse.1	-	7	1398	c.1166T>G	c.(1165-1167)ATC>AGC	p.I389S	FAM5C_uc010pot.1_Missense_Mutation_p.I287S	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	389						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TGGCAGGCTGATGAGGGGTTG	0.383000													4	131					0	0	0.014758	0	0	
ASPM	259266	broad.mit.edu	37	1	197086984	197086984	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:197086984T>G	uc001gtu.2	-	17	4257	c.4000A>C	c.(4000-4002)AAA>CAA	p.K1334Q	ASPM_uc001gtv.2_Missense_Mutation_p.K1334Q|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1334					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ATTAATAATTTTCTCTGTGCT	0.303000													9	323					0	0	0.004482	0	0	
KIF14	9928	broad.mit.edu	37	1	200587269	200587269	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:200587269T>G	uc010ppk.1	-	2	1022	c.583A>C	c.(583-585)AAA>CAA	p.K195Q	KIF14_uc010ppj.1_5'UTR	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	195	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TCTTTGTATTTCTTATCAGCC	0.368000													6	322					0	0	0.001984	0	0	
CAMSAP1L1	23271	broad.mit.edu	37	1	200816802	200816802	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:200816802T>G	uc001gvl.2	+	11	1530	c.1260T>G	c.(1258-1260)GTT>GTG	p.V420V	CAMSAP1L1_uc001gvk.2_Silent_p.V409V|CAMSAP1L1_uc001gvm.2_Silent_p.V393V	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	420						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TGTCTTATGTTGATGGCTTCA	0.318000													26	156					0	0	0.027356	0	0	
LMOD1	25802	broad.mit.edu	37	1	201869385	201869385	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:201869385A>T	uc001gxb.2	-	2	1004	c.756T>A	c.(754-756)GAT>GAA	p.D252E	LMOD1_uc010ppu.1_Missense_Mutation_p.D201E	NM_012134	NP_036266	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	252	8 X approximate tandem repeats.|6.				muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			ovary(1)|pancreas(1)|skin(1)	3						TTACCTTCTCATCCTCCTTTT	0.383000													3	75					0	0	0.004672	0	0	
FMOD	2331	broad.mit.edu	37	1	203317106	203317106	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:203317106T>G	uc001gzr.2	-	2	429	c.293A>C	c.(292-294)AAG>ACG	p.K98T	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	98	LRRNT.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			GGGCAGGTACTTGAGGTTGCG	0.582000													4	42					0	0	0.009096	0	0	
TRAF3IP3	80342	broad.mit.edu	37	1	209950798	209950798	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:209950798A>G	uc001hho.2	+	12	1445	c.1155A>G	c.(1153-1155)AGA>AGG	p.R385R	TRAF3IP3_uc001hhl.2_Silent_p.R365R|TRAF3IP3_uc001hhm.1_Intron|TRAF3IP3_uc001hhn.2_Silent_p.R365R|TRAF3IP3_uc009xcr.2_Silent_p.R385R	NM_025228	NP_079504	Q9Y228	T3JAM_HUMAN	TRAF3-interacting JNK-activating modulator	385	Cytoplasmic (Potential).|Potential.					integral to membrane	protein binding			large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.045)		AAGGGGACAGAGACCTGTGCA	0.512000													4	76					0	0	0.009096	0	0	
VASH2	79805	broad.mit.edu	37	1	213147373	213147373	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:213147373A>T	uc001hjy.2	+	6	1160	c.956A>T	c.(955-957)CAG>CTG	p.Q319L	VASH2_uc001hjv.2_RNA|VASH2_uc001hjx.2_Missense_Mutation_p.Q254L|VASH2_uc010ptn.1_Missense_Mutation_p.Q215L|VASH2_uc001hjw.2_Missense_Mutation_p.Q275L	NM_001136475	NP_001129947	Q86V25	VASH2_HUMAN	vasohibin 2 isoform 3	319					positive regulation of angiogenesis|positive regulation of endothelial cell proliferation	cytoplasm					0				OV - Ovarian serous cystadenocarcinoma(81;0.00479)|all cancers(67;0.00844)|GBM - Glioblastoma multiforme(131;0.0496)|Epithelial(68;0.0986)		AGAAGGAGACAGGCAAGCCCC	0.552000													7	50					0	0	0.006214	0	0	
CENPF	1063	broad.mit.edu	37	1	214815833	214815833	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:214815833G>A	uc001hkm.2	+	12	4326	c.4152G>A	c.(4150-4152)TTG>TTA	p.L1384L		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGGCTCCATTGGACGAGAGTA	0.423000													20	95					0	0	0.008871	0	0	
TP53BP2	7159	broad.mit.edu	37	1	223971971	223971971	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:223971971G>A	uc010pvb.1	-	17	3501	c.3209C>T	c.(3208-3210)GCG>GTG	p.A1070V	TP53BP2_uc001hod.2_Missense_Mutation_p.A941V|TP53BP2_uc010puz.1_Missense_Mutation_p.A303V|TP53BP2_uc010pva.1_Missense_Mutation_p.A709V	NM_001031685	NP_001026855	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2 isoform 1	1064	Mediates interaction with APC2.|SH3.				apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(2)|lung(1)	3				GBM - Glioblastoma multiforme(131;0.0958)		ATCCCAAAGCGCATAAATGAC	0.403000													4	177					0	0	0.009096	0	0	
PARP1	142	broad.mit.edu	37	1	226553738	226553738	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:226553738A>T	uc001hqd.3	-	18	2593	c.2422T>A	c.(2422-2424)TCT>ACT	p.S808T		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	808	PARP catalytic.				cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		GCTTCTTCAGAATCTCTGTCA	0.448000								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					7	94					0	0	0.001984	0	0	
PARP1	142	broad.mit.edu	37	1	226570854	226570854	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:226570854A>C	uc001hqd.3	-	8	1213	c.1042T>G	c.(1042-1044)TTG>GTG	p.L348V		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	348					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TTAACCTTCAATTTCTTGAGG	0.498000								Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					5	413					0	0	0.021553	0	0	
C1orf198	84886	broad.mit.edu	37	1	230979513	230979513	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:230979513T>C	uc001hub.2	-	3	558	c.514A>G	c.(514-516)AGG>GGG	p.R172G	C1orf198_uc009xfh.1_Missense_Mutation_p.R42G|C1orf198_uc001huc.1_5'UTR|C1orf198_uc001hud.1_Missense_Mutation_p.R134G	NM_032800	NP_116189	Q9H425	CA198_HUMAN	hypothetical protein LOC84886 isoform 1	172											0	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				CTGGAGGACCTGCTGCCTTGG	0.667000													27	197					0	0	0.009535	0	0	
SIPA1L2	57568	broad.mit.edu	37	1	232564266	232564266	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:232564266T>A	uc001hvg.2	-	15	4459	c.4301A>T	c.(4300-4302)CAG>CTG	p.Q1434L	SIPA1L2_uc001hvf.2_Missense_Mutation_p.Q508L	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1434					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CACCACTGTCTGATGCTGAGT	0.438000													20	119					0	0	0.014323	0	0	
RYR2	6262	broad.mit.edu	37	1	237730077	237730077	+	Splice_Site	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:237730077T>C	uc001hyl.1	+	28	3543	c.3423_splice	c.e28+2	p.K1141_splice		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCTTCAAGGTGAGTGGACTT	0.532000													8	197					0	0	0.008291	0	0	
RYR2	6262	broad.mit.edu	37	1	237806673	237806673	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:237806673T>C	uc001hyl.1	+	48	7388	c.7268T>C	c.(7267-7269)TTG>TCG	p.L2423S		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2423	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGTCCATTTTGAGATCCCTC	0.418000													35	238					0	0	0.021022	0	0	
ZNF496	84838	broad.mit.edu	37	1	247486469	247486469	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr1:247486469A>G	uc001ico.2	-	5	1103	c.638T>C	c.(637-639)CTC>CCC	p.L213P	ZNF496_uc009xgv.2_Missense_Mutation_p.L213P|ZNF496_uc001icp.2_Missense_Mutation_p.L213P|ZNF496_uc010pyv.1_Missense_Mutation_p.L213P	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	213					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GGGTAGCTGGAGGGTGGTCAC	0.522000													3	107					0	0	0.004672	0	0	
DIP2C	22982	broad.mit.edu	37	10	408454	408454	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:408454G>A	uc001ifp.2	-	22	2860	c.2770C>T	c.(2770-2772)CCT>TCT	p.P924S	DIP2C_uc009xhi.1_Missense_Mutation_p.P310S|DIP2C_uc010pzz.1_Missense_Mutation_p.P245S	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	924						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CGAGGCTTAGGCAAGTTTGTG	0.567000													6	90					0	0	0.021553	0	0	
UPF2	26019	broad.mit.edu	37	10	12077149	12077149	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:12077149C>T	uc001ila.2	-	1	748	c.274G>A	c.(274-276)GAA>AAA	p.E92K	UPF2_uc001ilb.2_Missense_Mutation_p.E92K|UPF2_uc001ilc.2_Missense_Mutation_p.E92K|UPF2_uc009xiz.1_Missense_Mutation_p.E92K	NM_080599	NP_542166	Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog	92	Potential.|Glu/Lys-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			central_nervous_system(2)|ovary(1)	3		Renal(717;0.228)				tttttttcttcctcttctttt	0.308000													11	274					0	0	0.008291	0	0	
NMT2	9397	broad.mit.edu	37	10	15174868	15174868	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:15174868T>G	uc001inz.1	-	6	751	c.667A>C	c.(667-669)AAA>CAA	p.K223Q	NMT2_uc001ioa.1_Missense_Mutation_p.K210Q|NMT2_uc009xjo.1_Missense_Mutation_p.K223Q|NMT2_uc010qbz.1_Missense_Mutation_p.K35Q	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	223					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						CCGACCAGTTTTTTATTTGAA	0.468000													35	143					0	0	0.017118	0	0	
ITGA8	8516	broad.mit.edu	37	10	15639293	15639293	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:15639293A>G	uc001ioc.1	-	21	2124	c.2124T>C	c.(2122-2124)TTT>TTC	p.F708F	ITGA8_uc010qcb.1_Silent_p.F693F	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	708	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						TCAGTGGTCGAAATCCCTACA	0.502000													26	131					0	0	0.021523	0	0	
MASTL	84930	broad.mit.edu	37	10	27470425	27470425	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:27470425A>C	uc001itm.2	+	11	3036	c.2397A>C	c.(2395-2397)GAA>GAC	p.E799D	MASTL_uc001itl.2_Missense_Mutation_p.E798D|MASTL_uc009xkw.1_Missense_Mutation_p.E760D|MASTL_uc009xkx.1_RNA	NM_032844	NP_116233	Q96GX5	GWL_HUMAN	microtubule associated serine/threonine	799	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|mitosis|negative regulation of protein phosphatase type 2A activity|regulation of cell cycle|response to DNA damage stimulus	centrosome|cleavage furrow|nucleus	ATP binding|protein phosphatase 2A binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CTTGGCCAGAAGGTGAAGAAA	0.294000													28	201					0	0	0.006320	0	0	
ERCC6	2074	broad.mit.edu	37	10	50678377	50678377	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:50678377T>G	uc001jhs.3	-	18	3783	c.3629A>C	c.(3628-3630)AAG>ACG	p.K1210T	ERCC6_uc009xod.2_Missense_Mutation_p.K370T|ERCC6_uc010qgr.1_Missense_Mutation_p.K580T|ERCC6_uc001jhr.3_Missense_Mutation_p.K578T	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1210					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						TCTGCAATGCTTAGAGTTCTT	0.423000								Direct_reversal_of_damage|NER					76	788					0	0	0.014410	0	0	
ANK3	288	broad.mit.edu	37	10	61828586	61828586	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:61828586T>C	uc001jky.2	-	37	12245	c.12053A>G	c.(12052-12054)GAA>GGA	p.E4018G	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	4018					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CATCTTTTTTTCTTCTTCAGA	0.458000													54	350					0	0	0.014410	0	0	
PCBD1	5092	broad.mit.edu	37	10	72644971	72644971	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:72644971T>G	uc001jrn.1	-	3	405	c.154A>C	c.(154-156)AGA>CGA	p.R52R		NM_000281	NP_000272	P61457	PHS_HUMAN	pterin-4 alpha-carbinolamine	52					L-phenylalanine catabolic process|regulation of transcription, DNA-dependent|tetrahydrobiopterin biosynthetic process|transcription, DNA-dependent	cytosol|nucleus	4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|transcription coactivator activity				0						AGGGCCACTCTTGTCATGAAC	0.507000													10	98					0	0	0.006214	0	0	
CDHR1	92211	broad.mit.edu	37	10	85955269	85955269	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:85955269G>A	uc001kcv.2	+	2	75	c.75G>A	c.(73-75)CCG>CCA	p.P25P	CDHR1_uc001kcw.2_Silent_p.P25P	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	25	Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						ACTTCGCCCCGCACTTCTTCG	0.612000													11	37					0	0	0.010729	0	0	
GRID1	2894	broad.mit.edu	37	10	87628808	87628808	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:87628808G>T	uc001kdl.1	-	6	1011	c.910C>A	c.(910-912)CTG>ATG	p.L304M	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	304	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TCGCAGAGCAGGGAGGAGATG	0.577000										Multiple Myeloma(13;0.14)			7	154					1.12685e-05	1.1632e-05	0.004482	1	0	
TCTN3	26123	broad.mit.edu	37	10	97440352	97440352	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:97440352A>C	uc001klb.3	-	13	1711	c.1467T>G	c.(1465-1467)ACT>ACG	p.T489T	TCTN3_uc001kla.3_Silent_p.T333T|TCTN3_uc010qoi.1_Silent_p.T341T	NM_015631	NP_056446	Q6NUS6	TECT3_HUMAN	tectonic 3 isoform a precursor	489	Extracellular (Potential).				apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		GACAGCAGGAAGTACAGTTTA	0.458000													55	176					0	0	0.014410	0	0	
ZNF518A	9849	broad.mit.edu	37	10	97919522	97919522	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:97919522T>G	uc001klp.2	+	6	4300	c.3443T>G	c.(3442-3444)TTT>TGT	p.F1148C	ZNF518A_uc001klo.1_Missense_Mutation_p.F618C|ZNF518A_uc001klq.2_Missense_Mutation_p.F1148C|ZNF518A_uc001klr.2_Missense_Mutation_p.F1148C	NM_014803	NP_055618	Q6AHZ1	Z518A_HUMAN	zinc finger protein 518	1148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		CTGAAAATTTTTAACCCTGTT	0.353000													3	194					0	0	0.004672	0	0	
C10orf28	27291	broad.mit.edu	37	10	99968636	99968636	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:99968636A>C	uc001kow.3	+	4	1060	c.765A>C	c.(763-765)GGA>GGC	p.G255G	C10orf28_uc001kox.3_Silent_p.G255G|C10orf28_uc001koy.3_Silent_p.G255G|C10orf28_uc009xvx.2_Silent_p.G255G|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	255							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		CATCAGATGGAATATTGAATC	0.393000													10	203					0	0	0.006214	0	0	
GSTO2	119391	broad.mit.edu	37	10	106058933	106058933	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:106058933A>C	uc001kyb.2	+	7	1251	c.623A>C	c.(622-624)AAG>ACG	p.K208T	GSTO2_uc010qqx.1_Missense_Mutation_p.K174T|GSTO2_uc001kyc.2_Missense_Mutation_p.K180T|GSTO2_uc010qqy.1_Missense_Mutation_p.E110D	NM_183239	NP_899062	Q9H4Y5	GSTO2_HUMAN	glutathione S-transferase omega 2	208	GST C-terminal.				water-soluble vitamin metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.178)		Epithelial(162;1.14e-09)|all cancers(201;3.89e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0155)	Glutathione(DB00143)	TCAGCCATGAAGTGGGACCCC	0.517000													13	165					0	0	0.004990	0	0	
TCF7L2	6934	broad.mit.edu	37	10	114710655	114710655	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:114710655C>T	uc001lae.3	+	1	647	c.140C>T	c.(139-141)TCT>TTT	p.S47F	TCF7L2_uc001lac.3_Missense_Mutation_p.S47F|TCF7L2_uc010qrk.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrl.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrm.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrn.1_Missense_Mutation_p.S47F|TCF7L2_uc001lad.3_Missense_Mutation_p.S47F|TCF7L2_uc001lag.3_Missense_Mutation_p.S47F|TCF7L2_uc001laf.3_Missense_Mutation_p.S47F|TCF7L2_uc010qro.1_Missense_Mutation_p.S47F|TCF7L2_uc001lah.2_Missense_Mutation_p.S47F|TCF7L2_uc010qrp.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrq.1_Missense_Mutation_p.S47F|TCF7L2_uc010qrr.1_5'Flank|TCF7L2_uc010qrs.1_5'Flank|TCF7L2_uc010qrt.1_5'Flank	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	47	CTNNB1-binding (By similarity).				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		GTCAAATCGTCTCTAGTCAAT	0.498000													9	32					0	0	0.006214	0	0	
NHLRC2	374354	broad.mit.edu	37	10	115636359	115636359	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:115636359T>G	uc001lax.1	+	3	623	c.411T>G	c.(409-411)CTT>CTG	p.L137L		NM_198514	NP_940916	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	137	Thioredoxin.				cell redox homeostasis					ovary(1)	1				Epithelial(162;0.017)|all cancers(201;0.0187)		GTGCTGTTCTTCGATACAACA	0.403000													6	256					0	0	0.001984	0	0	
ADRB1	153	broad.mit.edu	37	10	115804230	115804230	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:115804230G>A	uc001lba.2	+	1	425	c.339G>A	c.(337-339)CCG>CCA	p.P113P		NM_000684	NP_000675	P08588	ADRB1_HUMAN	beta-1-adrenergic receptor	113	Helical; Name=2; (By similarity).				positive regulation of cAMP biosynthetic process	integral to plasma membrane	alpha-2A adrenergic receptor binding|beta1-adrenergic receptor activity|protein heterodimerization activity				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0124)|all cancers(201;0.0298)	Acebutolol(DB01193)|Alprenolol(DB00866)|Amiodarone(DB01118)|Arbutamine(DB01102)|Atenolol(DB00335)|Betaxolol(DB00195)|Bevantolol(DB01295)|Bisoprolol(DB00612)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Desipramine(DB01151)|Dobutamine(DB00841)|Dopamine(DB00988)|Epinephrine(DB00668)|Esmolol(DB00187)|Isoetharine(DB00221)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Metoprolol(DB00264)|Nadolol(DB01203)|Norepinephrine(DB00368)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Practolol(DB01297)|Propranolol(DB00571)|Risperidone(DB00734)|Timolol(DB00373)|Ziprasidone(DB00246)	TGGTGGTGCCGTTCGGGGCCA	0.667000													21	76					0	0	0.024334	0	0	
PRAP1	118471	broad.mit.edu	37	10	135165920	135165920	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr10:135165920A>G	uc001lmp.2	+	5	510	c.432A>G	c.(430-432)CAA>CAG	p.Q144Q	PRAP1_uc001lmr.2_Silent_p.Q135Q|PRAP1_uc001lmq.1_Silent_p.Q116Q	NM_145202	NP_660203	Q96NZ9	PRAP1_HUMAN	proline-rich acidic protein 1 isoform 1	144						extracellular region					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.08e-06)|OV - Ovarian serous cystadenocarcinoma(35;7.88e-06)|Epithelial(32;9.48e-06)		AGGAAGACCAAGACCACATCT	0.672000													3	135					0	0	0.004672	0	0	
OR51A7	119687	broad.mit.edu	37	11	4928908	4928908	+	Missense_Mutation	SNP	C	A	A	rs142232152	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:4928908C>A	uc010qyq.1	+	1	309	c.309C>A	c.(307-309)TTC>TTA	p.F103L		NM_001004749	NP_001004749	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGAATTCTTCATTCATGGAT	0.438000													37	287					1.42033e-22	1.51732e-22	0.019004	1	0	
UBQLNL	143630	broad.mit.edu	37	11	5536993	5536993	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:5536993C>A	uc001maz.3	-	1	964	c.679G>T	c.(679-681)GAG>TAG	p.E227*	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	227										large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CTGGCCAGCTCCAGAGTCTGC	0.453000													11	300					0.00010058	0.000103069	0.013537	1	0	
DNHD1	144132	broad.mit.edu	37	11	6588890	6588890	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:6588890T>C	uc001mdw.3	+	36	12715	c.12151T>C	c.(12151-12153)TGC>CGC	p.C4051R	DNHD1_uc001mea.3_Missense_Mutation_p.C320R|DNHD1_uc001meb.2_Missense_Mutation_p.C319R|DNHD1_uc001mec.2_Missense_Mutation_p.C319R|DNHD1_uc010rao.1_Missense_Mutation_p.C309R|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4051					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCGACCTGAGTGCCTGGCAGG	0.612000													8	44					0	0	0.003080	0	0	
ST5	6764	broad.mit.edu	37	11	8732693	8732693	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:8732693C>T	uc001mgt.2	-	10	2444	c.2258G>A	c.(2257-2259)TGG>TAG	p.W753*	ST5_uc009yfr.2_Nonsense_Mutation_p.W333*|ST5_uc001mgu.2_Nonsense_Mutation_p.W333*|ST5_uc001mgv.2_Nonsense_Mutation_p.W753*|ST5_uc010rbq.1_RNA|ST5_uc010rbp.1_Nonsense_Mutation_p.W266*|ST5_uc009yfs.2_RNA	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	753	UDENN.				positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CACAGGAAGCCAGTCCTTGGC	0.592000													23	104					0	0	0.021523	0	0	
MICAL2	9645	broad.mit.edu	37	11	12262590	12262590	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:12262590C>T	uc001mjz.2	+	18	2506	c.2218C>T	c.(2218-2220)CGC>TGC	p.R740C	MICAL2_uc010rch.1_Intron|MICAL2_uc001mka.2_Missense_Mutation_p.R740C|MICAL2_uc010rci.1_Missense_Mutation_p.R740C|MICAL2_uc001mkb.2_Intron|MICAL2_uc001mkc.2_Intron|MICAL2_uc001mkd.2_Intron|MICAL2_uc010rcj.1_Intron|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	740						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CTCCCAGGAACGCCGTGTCTC	0.577000													19	185					0	0	0.008871	0	0	
MICALCL	84953	broad.mit.edu	37	11	12345546	12345546	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:12345546A>C	uc001mkg.1	+	5	1855	c.1564A>C	c.(1564-1566)AGA>CGA	p.R522R		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	522	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		ACTTAGAAGAAGAAAGAAGCT	0.338000													15	87					0	0	0.024245	0	0	
SAAL1	113174	broad.mit.edu	37	11	18124847	18124847	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:18124847T>C	uc001mnq.2	-	2	232	c.182A>G	c.(181-183)CAG>CGG	p.Q61R	SAAL1_uc001mnr.2_Missense_Mutation_p.Q61R|SAAL1_uc001mns.2_RNA|SAAL1_uc009yhf.2_Missense_Mutation_p.Q61R	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	61					acute-phase response	extracellular region	binding				0						CTCCGTCAGCTGCTCCTCATC	0.388000													6	320					0	0	0.013537	0	0	
PRMT3	10196	broad.mit.edu	37	11	20473684	20473684	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:20473684T>A	uc001mqb.2	+	11	1219	c.1002T>A	c.(1000-1002)TTT>TTA	p.F334L	PRMT3_uc001mqc.2_Missense_Mutation_p.F257L|PRMT3_uc010rdn.1_Missense_Mutation_p.F272L	NM_005788	NP_005779	O60678	ANM3_HUMAN	protein arginine methyltransferase 3 isoform 1	334							zinc ion binding				0						AGGGCTATTTTCTTCTGTTTG	0.338000													17	125					0	0	0.007413	0	0	
ANO5	203859	broad.mit.edu	37	11	22301112	22301112	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:22301112T>G	uc001mqi.2	+	22	2860	c.2543T>G	c.(2542-2544)TTT>TGT	p.F848C	ANO5_uc001mqj.2_Missense_Mutation_p.F847C	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	848	Helical; (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TTAGTTAAATTTTTGCTGGCC	0.363000													13	99					0	0	0.013537	0	0	
PAMR1	25891	broad.mit.edu	37	11	35454104	35454104	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:35454104T>G	uc001mwg.2	-	11	2006	c.1963A>C	c.(1963-1965)ACT>CCT	p.T655P	PAMR1_uc001mwf.2_Missense_Mutation_p.T672P|PAMR1_uc010rew.1_Missense_Mutation_p.T544P|PAMR1_uc010rex.1_Missense_Mutation_p.T615P	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	655	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GAAGGGGCAGTGGGTTCCCAG	0.587000													11	61					0	0	0.008291	0	0	
OR5T3	390154	broad.mit.edu	37	11	56019824	56019824	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:56019824A>C	uc010rjd.1	+	1	149	c.149A>C	c.(148-150)GAT>GCT	p.D50A		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	50	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					TTCACAGATGATTTTGAGCTG	0.378000													13	171					0	0	0.020292	0	0	
GLYAT	10249	broad.mit.edu	37	11	58480280	58480280	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:58480280A>G	uc001nnb.2	-	4	424	c.269T>C	c.(268-270)CTT>CCT	p.L90P	GLYAT_uc001nnc.2_Missense_Mutation_p.L90P	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	90					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TGGTGATCCAAGGAATTCCTG	0.398000													23	178					0	0	0.016522	0	0	
GLYATL1	92292	broad.mit.edu	37	11	58723472	58723472	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:58723472G>A	uc001nnf.2	+	8	1257	c.881G>A	c.(880-882)TGC>TAC	p.C294Y	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.C325Y|GLYATL1_uc001nni.1_Missense_Mutation_p.C294Y|GLYATL1_uc001nnj.1_Missense_Mutation_p.C294Y			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	294						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	CAATGGACTTGCTACCCACAG	0.423000													15	121					0	0	0.024245	0	0	
OR5A1	219982	broad.mit.edu	37	11	59211523	59211523	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:59211523T>C	uc001nnx.1	+	1	882	c.882T>C	c.(880-882)AGT>AGC	p.S294S		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	294	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						TCATTTACAGTTTGAGGAACA	0.453000													9	323					0	0	0.004482	0	0	
RAB3IL1	5866	broad.mit.edu	37	11	61675527	61675527	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:61675527T>G	uc001nso.2	-	2	421	c.263A>C	c.(262-264)AAG>ACG	p.K88T	RAB3IL1_uc001nsp.2_Missense_Mutation_p.K135T	NM_013401	NP_037533	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	88	Potential.						protein binding			skin(2)|central_nervous_system(1)	3						GGCACCCACCTTCTGCGCTCT	0.637000													4	81					0	0	0.009096	0	0	
AHNAK	79026	broad.mit.edu	37	11	62289401	62289401	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:62289401A>C	uc001ntl.2	-	5	12788	c.12488T>G	c.(12487-12489)GTT>GGT	p.V4163G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4163					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CTTGATGTCAACTTCAGGGCC	0.507000													32	250					0	0	0.012213	0	0	
AHNAK	79026	broad.mit.edu	37	11	62298592	62298592	+	Silent	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:62298592T>A	uc001ntl.2	-	5	3597	c.3297A>T	c.(3295-3297)CCA>CCT	p.P1099P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1099					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TGTCCACATCTGGAACCTGCA	0.453000													38	313					0	0	0.021022	0	0	
EML3	256364	broad.mit.edu	37	11	62376884	62376884	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:62376884G>A	uc001ntu.1	-	6	1008	c.700C>T	c.(700-702)CGC>TGC	p.R234C	EML3_uc001ntr.1_Missense_Mutation_p.R206C|EML3_uc001nts.1_Missense_Mutation_p.R206C|EML3_uc001ntt.1_Missense_Mutation_p.R118C|EML3_uc010rly.1_Missense_Mutation_p.R234C|EML3_uc009yny.1_Missense_Mutation_p.R17C	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	234						cytoplasm|microtubule	protein binding			ovary(1)	1						TCAAGGCTGCGGATGCCAGAC	0.577000													12	87					0	0	0.024245	0	0	
RTN3	10313	broad.mit.edu	37	11	63521149	63521149	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:63521149T>G	uc001nxq.2	+	7	3150	c.2963T>G	c.(2962-2964)TTC>TGC	p.F988C	RTN3_uc001nxo.2_Missense_Mutation_p.F192C|RTN3_uc001nxm.2_Missense_Mutation_p.F211C|RTN3_uc001nxn.2_Missense_Mutation_p.F969C|RTN3_uc001nxp.2_Missense_Mutation_p.F192C|RTN3_uc009yov.2_Missense_Mutation_p.F876C|RTN3_uc010rmt.1_RNA|RTN3_uc010rmu.1_Intron	NM_201428	NP_958831	O95197	RTN3_HUMAN	reticulon 3 isoform b	988	Helical; (Potential).|Interaction with FADD.|Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				ovary(1)	1						CTGCTCATTTTCAGTGTCCCG	0.378000													6	389					0	0	0.001984	0	0	
SF1	7536	broad.mit.edu	37	11	64536752	64536752	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:64536752T>G	uc001obb.1	-	7	1099	c.722A>C	c.(721-723)AAG>ACG	p.K241T	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Missense_Mutation_p.K215T|SF1_uc001oaz.1_Missense_Mutation_p.K366T|SF1_uc001oba.1_Missense_Mutation_p.K241T|SF1_uc001obc.1_Missense_Mutation_p.K241T|SF1_uc001obd.1_Missense_Mutation_p.K241T|SF1_uc001obe.1_Missense_Mutation_p.K126T|SF1_uc010rno.1_Missense_Mutation_p.K126T	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	241					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						AAGCTGCATCTTCCGTAGATC	0.473000													23	119					0	0	0.021523	0	0	
PPP2R5B	5526	broad.mit.edu	37	11	64694201	64694201	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:64694201C>T	uc001oby.2	+	3	802	c.217C>T	c.(217-219)CTG>TTG	p.L73L	PPP2R5B_uc001obz.2_Silent_p.L73L	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	73					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						GGCTTCCGAGCTGCACGAGCT	0.662000													14	61					0	0	0.020292	0	0	
B3GNT1	11041	broad.mit.edu	37	11	66113606	66113606	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:66113606C>T	uc001ohr.2	-	2	1307	c.1162G>A	c.(1162-1164)GCT>ACT	p.A388T	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	388	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						TGATTTTCAGCCTCCTTTTGG	0.512000													38	242					0	0	0.021022	0	0	
PC	5091	broad.mit.edu	37	11	66617526	66617526	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:66617526C>T	uc001ojn.1	-	18	2829	c.2780G>A	c.(2779-2781)AGC>AAC	p.S927N	PC_uc001ojo.1_Missense_Mutation_p.S927N|PC_uc001ojp.1_Missense_Mutation_p.S927N|PC_uc001ojm.1_5'Flank	NM_022172	NP_071504	P11498	PYC_HUMAN	pyruvate carboxylase precursor	927					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			ovary(2)|lung(1)|kidney(1)	4		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CTCTGCCCGGCTCAATCCATT	0.642000													10	145					0	0	0.016723	0	0	
KRTAP5-8	57830	broad.mit.edu	37	11	71249236	71249236	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:71249236T>G	uc001oqr.1	+	1	166	c.135T>G	c.(133-135)TGT>TGG	p.C45W		NM_021046	NP_066384	O75690	KRA58_HUMAN	keratin associated protein 5-8	45	9 X 4 AA repeats of C-C-X-P.					extracellular region|keratin filament	structural constituent of epidermis				0						TGCCAGCCTGTTCCTGCTCCA	0.692000													28	168					0	0	0.019004	0	0	
KRTAP5-9	3846	broad.mit.edu	37	11	71259851	71259851	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:71259851C>A	uc001oqs.1	+	1	386	c.148C>A	c.(148-150)CCA>ACA	p.P50T		NM_005553	NP_005544	P26371	KRA59_HUMAN	keratin associated protein 5-9	50	3.|8 X 4 AA repeats of C-C-X-P.				epidermis development	keratin filament					0						CTGCTGTGTTCCAGCCTGTTC	0.647000													38	180					1.57019e-19	1.67234e-19	0.007835	1	0	
INPPL1	3636	broad.mit.edu	37	11	71939801	71939801	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:71939801C>T	uc001osf.2	+	4	575	c.428C>T	c.(427-429)CCG>CTG	p.P143L	INPPL1_uc001osg.2_5'UTR	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	143					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CCGCTGCCCCCGCGCTCTGGC	0.672000													11	43					0	0	0.008291	0	0	
KCTD14	65987	broad.mit.edu	37	11	77727862	77727862	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:77727862T>C	uc001oyw.3	-	2	570	c.545A>G	c.(544-546)TAT>TGT	p.Y182C		NM_023930	NP_076419	Q9BQ13	KCD14_HUMAN	potassium channel tetramerisation domain	182						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			GACCTCTGAATAATATGCATC	0.532000													46	280					0	0	0.013114	0	0	
NOX4	50507	broad.mit.edu	37	11	89073338	89073338	+	Missense_Mutation	SNP	C	A	A	rs55696571		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:89073338C>A	uc001pct.2	-	15	1578	c.1339G>T	c.(1339-1341)GAT>TAT	p.D447Y	NOX4_uc009yvr.2_Missense_Mutation_p.D422Y|NOX4_uc001pcu.2_Missense_Mutation_p.D373Y|NOX4_uc001pcw.2_Missense_Mutation_p.D140Y|NOX4_uc001pcx.2_Missense_Mutation_p.D100Y|NOX4_uc001pcv.2_Missense_Mutation_p.D407Y|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.D281Y|NOX4_uc009yvp.2_Missense_Mutation_p.D211Y|NOX4_uc010rtv.1_Missense_Mutation_p.D383Y|NOX4_uc009yvq.2_Missense_Mutation_p.D423Y	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	447	Cytoplasmic (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				TTCCAGTCATCCCTTTAAAAT	0.328000													18	165					8.00594e-06	8.2885e-06	0.007413	1	0	
AMOTL1	154810	broad.mit.edu	37	11	94528193	94528193	+	Silent	SNP	T	C	C	rs138638061	by1000genomes	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:94528193T>C	uc001pfb.2	+	2	236	c.66T>C	c.(64-66)TGT>TGC	p.C22C	AMOTL1_uc001pfc.2_Intron	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	22						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CTTCTGCTTGTTATAGCCCCA	0.507000													4	126					0	0	0.014758	0	0	
FAM76B	143684	broad.mit.edu	37	11	95516419	95516419	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:95516419T>G	uc001pfn.2	-	5	685	c.373A>C	c.(373-375)AAG>CAG	p.K125Q	FAM76B_uc001pfm.2_RNA	NM_144664	NP_653265	Q5HYJ3	FA76B_HUMAN	hypothetical protein LOC143684	125											0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CATAATAACTTTCCATCAACC	0.348000													4	122					0	0	0.014758	0	0	
JRKL	8690	broad.mit.edu	37	11	96125232	96125232	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:96125232G>A	uc009ywu.2	+	2	1671	c.1419G>A	c.(1417-1419)GAG>GAA	p.E473E	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Silent_p.E473E	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	473					central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		TAATTCCAGAGAAACATATTA	0.393000													7	57					0	0	0.003080	0	0	
DYNC2H1	79659	broad.mit.edu	37	11	102984309	102984309	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:102984309A>G	uc001pho.2	+	2	383	c.239A>G	c.(238-240)AAG>AGG	p.K80R	DYNC2H1_uc001phn.1_Missense_Mutation_p.K80R|DYNC2H1_uc009yxe.1_Missense_Mutation_p.K80R	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	80	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GTGTTTTTCAAGCTGCGACCT	0.303000													9	164					0	0	0.008291	0	0	
DYNC2H1	79659	broad.mit.edu	37	11	102984404	102984404	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:102984404G>A	uc001pho.2	+	2	478	c.334G>A	c.(334-336)GTA>ATA	p.V112I	DYNC2H1_uc001phn.1_Missense_Mutation_p.V112I|DYNC2H1_uc009yxe.1_Missense_Mutation_p.V112I	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	112	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTACCAAGCAGTACGGCAAGT	0.328000													12	78					0	0	0.013537	0	0	
PDGFD	80310	broad.mit.edu	37	11	103814315	103814315	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:103814315T>G	uc001phq.2	-	5	1009	c.637A>C	c.(637-639)AAA>CAA	p.K213Q	PDGFD_uc001php.2_Missense_Mutation_p.K207Q	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	213					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TCTGCAATTTTTTTGTCCAGA	0.433000													12	60					0	0	0.013537	0	0	
ARHGAP20	57569	broad.mit.edu	37	11	110462822	110462822	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:110462822C>T	uc001pkz.1	-	11	1307	c.1022G>A	c.(1021-1023)CGA>CAA	p.R341Q	ARHGAP20_uc001pky.1_Missense_Mutation_p.R318Q|ARHGAP20_uc009yyb.1_Missense_Mutation_p.R305Q|ARHGAP20_uc001pla.1_Missense_Mutation_p.R305Q|ARHGAP20_uc001plb.2_5'Flank	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	341					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GCTAGAACCTCGCCAGAAGGC	0.418000													31	211					0	0	0.015359	0	0	
MIR34C	407042	broad.mit.edu	37	11	111384173	111384173	+	RNA	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:111384173A>G	hsa-mir-34c|MI0000743	+			c.10A>G			BTG4_uc001plj.2_5'Flank|BTG4_uc001plk.2_5'Flank|uc001pll.2_RNA|C11orf88_uc009yyd.2_5'Flank|C11orf88_uc001pln.3_5'Flank|C11orf88_uc001plo.1_5'Flank																	0						GAGTCTAGTTACTAGGCAGTG	0.443000													5	85					0	0	0.021553	0	0	
BCO2	83875	broad.mit.edu	37	11	112065392	112065392	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:112065392T>G	uc001pnf.2	+	5	767	c.650T>G	c.(649-651)TTT>TGT	p.F217C	BCO2_uc001pne.1_Missense_Mutation_p.F44C|BCO2_uc001png.2_Intron|BCO2_uc001pnh.2_Missense_Mutation_p.F183C|BCO2_uc010rwt.1_Missense_Mutation_p.F112C|BCO2_uc009yyn.2_Missense_Mutation_p.F183C|BCO2_uc001pni.2_Missense_Mutation_p.F183C	NM_031938	NP_114144	Q9BYV7	BCDO2_HUMAN	beta-carotene dioxygenase 2 isoform a	217					carotene metabolic process|retinal metabolic process|retinoic acid metabolic process		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TGGAGCAAATTTATTGCTGTG	0.373000													24	157					0	0	0.021523	0	0	
FAM55D	54827	broad.mit.edu	37	11	114453400	114453400	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:114453400A>G	uc001ppc.2	-	3	621	c.440T>C	c.(439-441)CTG>CCG	p.L147P	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	147						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		ACCTGCCATCAGCGCTGGGGA	0.587000													10	55					0	0	0.006214	0	0	
C2CD2L	9854	broad.mit.edu	37	11	118981567	118981567	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:118981567A>C	uc001pvo.2	+	4	940	c.581A>C	c.(580-582)AAC>ACC	p.N194T	DPAGT1_uc010ryz.1_5'Flank|C2CD2L_uc001pvn.2_Missense_Mutation_p.N194T	NM_014807	NP_055622	O14523	C2C2L_HUMAN	transmembrane protein 24	194						integral to membrane					0						TTGGAAGTCAACCTGGAGGAA	0.547000													36	281					0	0	0.021022	0	0	
GRIK4	2900	broad.mit.edu	37	11	120673464	120673464	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:120673464A>G	uc001pxn.2	+	4	432	c.145A>G	c.(145-147)AAG>GAG	p.K49E	GRIK4_uc009zav.1_Missense_Mutation_p.K49E|GRIK4_uc009zaw.1_Missense_Mutation_p.K49E|GRIK4_uc009zax.1_Missense_Mutation_p.K49E	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	49	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CACCCTGGCCAAGAACCGCAT	0.582000											OREG0021427	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	105					0	0	0.004990	0	0	
TBCEL	219899	broad.mit.edu	37	11	120916421	120916421	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:120916421A>C	uc009zay.2	+	2	100	c.22A>C	c.(22-24)AGT>CGT	p.S8R	TBCEL_uc001pxo.2_Missense_Mutation_p.S8R|TBCEL_uc001pxp.2_5'UTR|TBCEL_uc001pxq.2_RNA	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	8						cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TAGTGGAAGAAGTTTCATGCA	0.353000													10	96					0	0	0.010729	0	0	
CHEK1	1111	broad.mit.edu	37	11	125513723	125513723	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:125513723C>T	uc009zbo.2	+	9	1743	c.851C>T	c.(850-852)TCA>TTA	p.S284L	CHEK1_uc010sbh.1_Missense_Mutation_p.S300L|CHEK1_uc010sbi.1_Missense_Mutation_p.S284L|CHEK1_uc001qcf.3_Missense_Mutation_p.S284L|CHEK1_uc009zbp.2_Missense_Mutation_p.S284L|CHEK1_uc001qcg.3_Missense_Mutation_p.S284L|CHEK1_uc009zbq.2_Missense_Mutation_p.S284L|CHEK1_uc001qci.1_RNA|CHEK1_uc001qcj.2_5'Flank	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	284					cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		GGTGGTGTGTCAGAGTCTCCC	0.378000								Other_conserved_DNA_damage_response_genes					8	104					0	0	0.008291	0	0	
CDON	50937	broad.mit.edu	37	11	125864268	125864268	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr11:125864268T>A	uc009zbw.2	-	14	2689	c.2561A>T	c.(2560-2562)AAC>ATC	p.N854I	CDON_uc001qdb.3_Missense_Mutation_p.N231I|CDON_uc001qdc.3_Missense_Mutation_p.N854I	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	854	Extracellular (Potential).|Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		AGTGTTATTGTTACTTGATGG	0.343000													9	65					0	0	0.004482	0	0	
Unknown	0	broad.mit.edu	37	12	92018	92018	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:92018T>C	uc010sdi.1	-	2	320	c.292A>G	c.(292-294)AGT>GGT	p.S98G	uc010sdj.1_RNA					SubName: Full=DEAD/H box polypeptide 11 like 11;																		GACTCCACACTCTCCTGGGTT	0.592000													5	8					0	0	0.014758	0	0	
KDM5A	5927	broad.mit.edu	37	12	401986	401986	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:401986T>C	uc001qif.1	-	27	5168	c.4805A>G	c.(4804-4806)GAG>GGG	p.E1602G	KDM5A_uc001qie.1_Missense_Mutation_p.E1607G	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1602					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						ATCATCAGACTCCTCTGCTCC	0.478000			T 	NUP98	AML								4	236					0	0	0.009096	0	0	
ITFG2	55846	broad.mit.edu	37	12	2929369	2929369	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:2929369A>C	uc001qlb.1	+	5	588	c.524A>C	c.(523-525)AAG>ACG	p.K175T	ITFG2_uc010seb.1_5'UTR|ITFG2_uc010sec.1_RNA	NM_018463	NP_060933	Q969R8	ITFG2_HUMAN	integrin alpha FG-GAP repeat containing 2	175											0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			GTGTCCCTCAAGAAATGGATG	0.602000													6	32					0	0	0.021553	0	0	
GRIN2B	2904	broad.mit.edu	37	12	13717464	13717464	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:13717464C>T	uc001rbt.2	-	13	2887	c.2708G>A	c.(2707-2709)CGC>CAC	p.R903H		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	903	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTTGGCCGTGCGCAGCAGGCG	0.582000													21	232					0	0	0.016522	0	0	
PIK3C2G	5288	broad.mit.edu	37	12	18691172	18691172	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:18691172T>G	uc001rdt.2	+	24	3399	c.3283T>G	c.(3283-3285)TTT>GTT	p.F1095V	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.F1136V|PIK3C2G_uc010sic.1_Missense_Mutation_p.F914V	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1095	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				TTTTCAAGATTTTGTGGAACT	0.393000													3	123					0	0	0.004672	0	0	
KCNJ8	3764	broad.mit.edu	37	12	21918912	21918912	+	Silent	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:21918912G>T	uc001rff.2	-	3	1358	c.1020C>A	c.(1018-1020)TCC>TCA	p.S340S		NM_004982	NP_004973	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel J8	340	Cytoplasmic (By similarity).					voltage-gated potassium channel complex					0					Levosimendan(DB00922)	TGCCAAATTTGGAGTAATCCA	0.493000													20	163					1.2644e-06	1.31096e-06	0.010504	1	0	
ITPR2	3709	broad.mit.edu	37	12	26875410	26875410	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:26875410C>T	uc001rhg.2	-	5	862	c.445G>A	c.(445-447)GTG>ATG	p.V149M	ITPR2_uc001rhh.1_Missense_Mutation_p.V87M|ITPR2_uc001rhi.1_Missense_Mutation_p.V149M	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	149	MIR 1.|Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCCAAGGACACACGCATGGCA	0.383000													25	187					0	0	0.007291	0	0	
FGD4	121512	broad.mit.edu	37	12	32791654	32791654	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:32791654A>C	uc001rkz.2	+	16	2445	c.1968A>C	c.(1966-1968)TCA>TCC	p.S656S	FGD4_uc001rlc.2_Silent_p.S741S|FGD4_uc001rky.2_Silent_p.S408S|FGD4_uc001rla.2_Silent_p.S312S|FGD4_uc010ske.1_Silent_p.S768S|FGD4_uc001rlb.1_RNA	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	656	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TGGAGAAGTCAAAACCTTGGC	0.433000													3	122					0	0	0.004672	0	0	
SFRS2IP	9169	broad.mit.edu	37	12	46320310	46320310	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:46320310A>G	uc001rox.2	-	11	3461	c.3174T>C	c.(3172-3174)TCT>TCC	p.S1058S	SFRS2IP_uc001row.2_Silent_p.S743S|SFRS2IP_uc001roy.1_Silent_p.S1132S	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1058					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		TTTTATTCCAAGAATTTCCTG	0.398000													5	162					0	0	0.021553	0	0	
LACRT	90070	broad.mit.edu	37	12	55026976	55026976	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:55026976C>T	uc001sgi.1	-	2	138	c.100G>A	c.(100-102)GAA>AAA	p.E34K		NM_033277	NP_150593	Q9GZZ8	LACRT_HUMAN	lacritin precursor	34					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			central_nervous_system(1)	1						GTCCCAGCTTCCTGGGCAGGA	0.582000													55	321					0	0	0.014410	0	0	
OR6C4	341418	broad.mit.edu	37	12	55945482	55945482	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:55945482A>C	uc010spp.1	+	1	472	c.472A>C	c.(472-474)ATC>CTC	p.I158L		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTTACCACCAATCATCCTGAT	0.478000													6	241					0	0	0.021553	0	0	
ESYT1	23344	broad.mit.edu	37	12	56530645	56530645	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:56530645A>C	uc001sjq.2	+	16	1800	c.1750A>C	c.(1750-1752)AAC>CAC	p.N584H	ESYT1_uc001sjr.2_Missense_Mutation_p.N594H	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	584						integral to membrane				ovary(4)|skin(1)	5						CTCTGGTCCAAACTCCAGACT	0.527000													18	129					0	0	0.004990	0	0	
MYO1A	4640	broad.mit.edu	37	12	57437101	57437101	+	Nonsense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:57437101C>A	uc001smw.3	-	11	1177	c.934G>T	c.(934-936)GAA>TAA	p.E312*	MYO1A_uc010sqz.1_Nonsense_Mutation_p.E150*|MYO1A_uc009zpd.2_Nonsense_Mutation_p.E312*	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	312	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						CTCTCTACTTCTTCTGAATTC	0.507000													19	107					2.94398e-08	3.07046e-08	0.007413	1	0	
DPY19L2	283417	broad.mit.edu	37	12	64061913	64061913	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:64061913A>G	uc001srp.1	-	1	442	c.261T>C	c.(259-261)AAT>AAC	p.N87N	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	87					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		GCGCCAGGGAATTACGGACGA	0.612000													28	148					0	0	0.007291	0	0	
WIF1	11197	broad.mit.edu	37	12	65460501	65460501	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:65460501C>T	uc001ssk.2	-	6	795	c.650G>A	c.(649-651)CGA>CAA	p.R217Q		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	217	EGF-like 2.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		ATTCATACATCGTGGGGTACA	0.423000			T	HMGA2	pleomorphic salivary gland adenoma								7	46					0	0	0.001984	0	0	
NUP107	57122	broad.mit.edu	37	12	69085815	69085815	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:69085815A>C	uc001suf.2	+	5	486	c.371A>C	c.(370-372)AAC>ACC	p.N124T	NUP107_uc001sug.2_Intron|NUP107_uc010stj.1_Missense_Mutation_p.N95T	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	124					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			CTGTTCACAAACACAGAGCCC	0.403000													3	140					0	0	0.004672	0	0	
SLC35E3	55508	broad.mit.edu	37	12	69141776	69141776	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:69141776G>C	uc001suh.2	+	2	691	c.469G>C	c.(469-471)GTG>CTG	p.V157L		NM_018656	NP_061126	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E2	157	Helical; (Potential).					integral to membrane					0	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			CCTTGGAATGGTGTTTGCTGC	0.308000													4	312					0	0	0.009096	0	0	
PTPRR	5801	broad.mit.edu	37	12	71092045	71092045	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:71092045T>G	uc001swi.1	-	8	1695	c.1279A>C	c.(1279-1281)AAT>CAT	p.N427H	PTPRR_uc001swh.1_Missense_Mutation_p.N182H|PTPRR_uc009zrs.2_Missense_Mutation_p.N276H|PTPRR_uc010stq.1_Missense_Mutation_p.N315H|PTPRR_uc010str.1_Missense_Mutation_p.N276H	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	427	Tyrosine-protein phosphatase.|Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		AGAAGCTTACTTGGTAAAATG	0.204000													4	120					0	0	0.009096	0	0	
GLIPR1L2	144321	broad.mit.edu	37	12	75816695	75816695	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:75816695C>T	uc001sxr.1	+	4	604	c.596C>T	c.(595-597)ACG>ATG	p.T199M	GLIPR1L2_uc001sxp.1_Missense_Mutation_p.T199M|GLIPR1L2_uc001sxq.1_Missense_Mutation_p.T92M	NM_152436	NP_689649	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	199						integral to membrane				ovary(1)	1						GGAACACTGACGAGAAGACCT	0.294000													24	250					0	0	0.008361	0	0	
E2F7	144455	broad.mit.edu	37	12	77423918	77423918	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:77423918A>C	uc001sym.3	-	10	1813	c.1577T>G	c.(1576-1578)CTT>CGT	p.L526R	E2F7_uc009zse.2_Missense_Mutation_p.L13R	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	526					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						TGCAGAAGCAAGTGAGACATC	0.527000													16	72					0	0	0.028581	0	0	
SLC5A8	160728	broad.mit.edu	37	12	101576638	101576638	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:101576638T>C	uc001thz.3	-	9	1498	c.1108A>G	c.(1108-1110)AAA>GAA	p.K370E		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	370	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						AAGTAAGGTTTGATTAGATCT	0.358000													16	130					0	0	0.004990	0	0	
NUP37	79023	broad.mit.edu	37	12	102512287	102512287	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:102512287C>T	uc001tjc.2	-	1	75	c.10G>A	c.(10-12)GAT>AAT	p.D4N	NUP37_uc009zub.1_Missense_Mutation_p.D4N|C12orf48_uc001tjd.2_5'Flank|C12orf48_uc001tje.2_5'Flank|C12orf48_uc001tjg.2_5'Flank|C12orf48_uc010swa.1_5'Flank|C12orf48_uc001tjf.2_5'Flank|C12orf48_uc001tjh.2_5'Flank|C12orf48_uc010swb.1_5'Flank|C12orf48_uc001tji.2_5'Flank	NM_024057	NP_076962	Q8NFH4	NUP37_HUMAN	nucleoporin 37kDa	4					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			ovary(1)	1						CTTGAGGCATCTTGCTTCATC	0.393000													28	192					0	0	0.010818	0	0	
MED13L	23389	broad.mit.edu	37	12	116446774	116446774	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:116446774T>C	uc001tvw.2	-	10	1499	c.1444A>G	c.(1444-1446)AGA>GGA	p.R482G		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	482					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ATTAAGGGTCTCTTTTGCAGC	0.463000													27	216					0	0	0.024334	0	0	
SBNO1	55206	broad.mit.edu	37	12	123805055	123805055	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:123805055T>G	uc010tap.1	-	18	2591	c.2591A>C	c.(2590-2592)AAA>ACA	p.K864T	SBNO1_uc010tao.1_Missense_Mutation_p.K863T|SBNO1_uc010taq.1_Intron	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	864	Potential.						ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTCAGCTAATTTTTCTAGCTT	0.453000													34	181					0	0	0.015359	0	0	
GTF2H3	2967	broad.mit.edu	37	12	124130078	124130078	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:124130078T>C	uc001ufo.1	+	3	196	c.170T>C	c.(169-171)CTT>CCT	p.L57P	GTF2H3_uc010tau.1_Missense_Mutation_p.L16P	NM_001516	NP_001507	Q13889	TF2H3_HUMAN	general transcription factor IIH, polypeptide 3,	57					mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	core TFIIH complex|holo TFIIH complex	damaged DNA binding|metal ion binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|translation factor activity, nucleic acid binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.1e-05)|Epithelial(86;0.000388)|all cancers(50;0.00362)		TCCAACAAACTTGCTGTGATA	0.383000								NER					3	81					0	0	0.004672	0	0	
SCARB1	949	broad.mit.edu	37	12	125294827	125294827	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:125294827G>A	uc001ugo.3	-	6	988	c.735C>T	c.(733-735)TTC>TTT	p.F245F	SCARB1_uc001ugn.3_Silent_p.F245F|SCARB1_uc001ugm.3_Silent_p.F245F|SCARB1_uc010tbd.1_Silent_p.F245F|SCARB1_uc010tbe.1_Silent_p.F204F|SCARB1_uc001ugp.3_Silent_p.F245F	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	245	Extracellular (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	CGGAATGCCAGAAGTCAACCT	0.567000													9	41					0	0	0.006214	0	0	
FZD10	11211	broad.mit.edu	37	12	130647613	130647613	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:130647613C>T	uc001uii.2	+	1	582	c.126C>T	c.(124-126)TGC>TGT	p.C42C	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	42	FZ.|Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TCCCGATGTGCAAGGACATCG	0.642000													3	19					0	0	0.021553	0	0	
CHFR	55743	broad.mit.edu	37	12	133433083	133433083	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr12:133433083T>C	uc001ulf.2	-	10	1320	c.1236A>G	c.(1234-1236)TCA>TCG	p.S412S	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Silent_p.S400S|CHFR_uc010tbs.1_Silent_p.S412S|CHFR_uc001uld.2_Silent_p.S371S|CHFR_uc010tbt.1_Silent_p.S320S	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	412					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TGTCAACGTCTGACAGCTCCA	0.512000													6	353					0	0	0.003080	0	0	
LOC284232	284232	broad.mit.edu	37	13	19419867	19419867	+	RNA	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:19419867T>G	uc010tcj.1	-	1		c.26243A>C				NR_027995				Homo sapiens ankyrin repeat domain 20 family, member A2 pseudogene (LOC284232), non-coding RNA.												0						AACAAGAAACTTAAATTTTCA	0.333000													4	80					0	0	0.009096	0	0	
LOC374491	374491	broad.mit.edu	37	13	25157654	25157654	+	RNA	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:25157654T>G	uc001upm.2	+	6		c.488T>G			LOC374491_uc001upn.2_RNA|LOC374491_uc001upo.2_5'Flank					Homo sapiens mRNA; cDNA DKFZp434J0717 (from clone DKFZp434J0717).												0						GCCTGTATTATTTTGGAGAAA	0.393000													6	29					0	0	0.001984	0	0	
NBEA	26960	broad.mit.edu	37	13	35692531	35692531	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:35692531T>C	uc001uvb.2	+	17	2369	c.2163T>C	c.(2161-2163)GAT>GAC	p.D721D		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	721						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATATTCATGATGTGCTACAGT	0.318000													12	12					0	0	0.016723	0	0	
NBEA	26960	broad.mit.edu	37	13	36242525	36242525	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:36242525C>T	uc001uvb.2	+	57	8825	c.8619C>T	c.(8617-8619)GAC>GAT	p.D2873D	NBEA_uc010abi.2_Silent_p.D1531D|NBEA_uc010tef.1_Silent_p.D666D|NBEA_uc001uvd.2_Silent_p.D451D	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2873	WD 4.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGAGCAGTGACGGCCAGAACC	0.423000													6	23					0	0	0.021553	0	0	
FREM2	341640	broad.mit.edu	37	13	39338478	39338478	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:39338478T>G	uc001uwv.2	+	3	5610	c.5301T>G	c.(5299-5301)AAT>AAG	p.N1767K		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	1767	Calx-beta 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TTCGTCTGAATTGGGCATGGA	0.343000													4	146					0	0	0.009096	0	0	
HNRNPA1L2	144983	broad.mit.edu	37	13	53216635	53216635	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:53216635A>C	uc001vgx.1	+	7	1081	c.8A>C	c.(7-9)AAG>ACG	p.K3T	HNRNPA1L2_uc001vgy.1_Missense_Mutation_p.K3T|HNRNPA1L2_uc001vgz.1_Missense_Mutation_p.K3T	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	3					mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						GTCATGTCTAAGTCAGCGTCT	0.433000													5	219					0	0	0.021553	0	0	
PCDH17	27253	broad.mit.edu	37	13	58298873	58298873	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:58298873A>C	uc001vhq.1	+	4	3817	c.2925A>C	c.(2923-2925)GTA>GTC	p.V975V	PCDH17_uc010aec.1_Silent_p.V974V|PCDH17_uc001vhr.1_Silent_p.V64V	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	975	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCTCTTTGTACCTACAGTTG	0.448000													12	120					0	0	0.020292	0	0	
PCDH9	5101	broad.mit.edu	37	13	67205388	67205388	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:67205388A>G	uc001vik.2	-	4	3986	c.3294T>C	c.(3292-3294)TCT>TCC	p.S1098S	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Silent_p.S1064S|PCDH9_uc010thl.1_Silent_p.S1056S	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1098	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TCTTGTCCGGAGAGGCCTGGT	0.512000													42	113					0	0	0.014410	0	0	
MYCBP2	23077	broad.mit.edu	37	13	77715012	77715012	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:77715012A>G	uc001vkf.2	-	51	7347	c.7256T>C	c.(7255-7257)GTC>GCC	p.V2419A	MYCBP2_uc010aev.2_Missense_Mutation_p.V1823A	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	2419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTTTGGTTTGACCAACTGAGT	0.408000													11	478					0	0	0.008291	0	0	
SLITRK5	26050	broad.mit.edu	37	13	88330472	88330472	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:88330472G>A	uc001vln.2	+	2	3048	c.2829G>A	c.(2827-2829)CCG>CCA	p.P943P	SLITRK5_uc010tic.1_Silent_p.P702P	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	943	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ACGTTGAGCCGGACTACCTCG	0.468000													46	142					0	0	0.013114	0	0	
DOCK9	23348	broad.mit.edu	37	13	99519764	99519764	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:99519764A>G	uc001vnt.2	-	30	3259	c.3204T>C	c.(3202-3204)TTT>TTC	p.F1068F	DOCK9_uc001vnw.2_Silent_p.F1067F|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.F1068F|DOCK9_uc010tis.1_Silent_p.F1067F|DOCK9_uc010tit.1_Silent_p.F1068F|DOCK9_uc010tiq.1_Silent_p.F32F|DOCK9_uc010afu.1_Silent_p.F914F	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	1068					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CTACACGGAGAAATTCAAACT	0.358000													6	278					0	0	0.001984	0	0	
IRS2	8660	broad.mit.edu	37	13	110434788	110434788	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr13:110434788G>A	uc001vqv.2	-	1	4127	c.3613C>T	c.(3613-3615)CGA>TGA	p.R1205*		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1205					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			TGCAACTGTCGTGGGGAGGTG	0.716000													2	0					0	0	0.004672	0	0	
OR4M1	441670	broad.mit.edu	37	14	20248901	20248901	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:20248901C>T	uc010tku.1	+	1	420	c.420C>T	c.(418-420)CTC>CTT	p.L140L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	140	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCGACGTCTCTGCTGTATCC	0.517000													39	848					0	0	0.009718	0	0	
RPGRIP1	57096	broad.mit.edu	37	14	21794020	21794020	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:21794020G>A	uc001wag.2	+	16	2398	c.2398G>A	c.(2398-2400)GAG>AAG	p.E800K	RPGRIP1_uc001wah.2_Missense_Mutation_p.E442K|RPGRIP1_uc001wai.2_Intron|RPGRIP1_uc001wak.2_Missense_Mutation_p.E275K|RPGRIP1_uc010aim.2_Missense_Mutation_p.E183K|RPGRIP1_uc001wal.2_Missense_Mutation_p.E159K|RPGRIP1_uc001wam.2_Missense_Mutation_p.E117K	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	800					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		ACCTCAGAACGAGCTGTGGAT	0.502000													15	53					0	0	0.004990	0	0	
PSMB11	122706	broad.mit.edu	37	14	23511989	23511989	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:23511989C>T	uc010ake.1	+	1	614	c.555C>T	c.(553-555)TAC>TAT	p.Y185Y		NM_001099780	NP_001093250	A5LHX3	PSB11_HUMAN	proteasome beta 11 subunit precursor	185					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00643)		CCTATGCCTACGGCGTGCTAG	0.642000													12	73					0	0	0.016723	0	0	
TGM1	7051	broad.mit.edu	37	14	24727813	24727813	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:24727813G>A	uc001wod.2	-	8	1350	c.1226C>T	c.(1225-1227)ACA>ATA	p.T409I	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	409					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	GGTAAGGGATGTGTCTGTGTC	0.577000													10	62					0	0	0.006214	0	0	
NOVA1	4857	broad.mit.edu	37	14	26949249	26949249	+	Silent	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:26949249C>A	uc001wpy.2	-	3	699	c.381G>T	c.(379-381)GTG>GTT	p.V127V	NOVA1_uc001wpz.2_Silent_p.V127V|NOVA1_uc001wqa.2_Silent_p.V5V|NOVA1_uc001wqb.2_Silent_p.V127V	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	130					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		CTGTCTTGGCCACATTTTGGG	0.433000													16	262					1.99824e-07	2.07793e-07	0.004990	1	0	
STRN3	29966	broad.mit.edu	37	14	31416341	31416341	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:31416341A>T	uc001wqu.2	-	5	887	c.671T>A	c.(670-672)CTG>CAG	p.L224Q	STRN3_uc001wqv.2_Missense_Mutation_p.L224Q|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	224					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		ACCTCCATTCAGGATCTGTTC	0.323000													4	195					0	0	0.009096	0	0	
ERO1L	30001	broad.mit.edu	37	14	53119797	53119797	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:53119797G>A	uc001wzv.2	-	12	1271	c.1045C>T	c.(1045-1047)CAT>TAT	p.H349Y	ERO1L_uc001wzw.2_RNA|ERO1L_uc010aof.2_RNA	NM_014584	NP_055399	Q96HE7	ERO1A_HUMAN	ERO1-like precursor	349					chaperone mediated protein folding requiring cofactor|electron transport chain|protein thiol-disulfide exchange|response to temperature stimulus|transport	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome	disulfide oxidoreductase activity|flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor				0	Breast(41;0.226)					TTGATTTCATGAAGTATTTCC	0.244000													4	74					0	0	0.009096	0	0	
TMEM30B	161291	broad.mit.edu	37	14	61747020	61747020	+	Silent	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:61747020G>T	uc001xfl.2	-	1	1511	c.846C>A	c.(844-846)GCC>GCA	p.A282A	PRKCH_uc010tsa.1_Intron|TMEM30B_uc010apr.1_RNA	NM_001017970	NP_001017970	Q3MIR4	CC50B_HUMAN	transmembrane protein 30B	282						integral to membrane					0				OV - Ovarian serous cystadenocarcinoma(108;0.107)|BRCA - Breast invasive adenocarcinoma(234;0.181)		TGACGCGGTAGGCGCCCCGCG	0.662000													3	22					0.00024832	0.000254095	0.009096	1	0	
SYNE2	23224	broad.mit.edu	37	14	64593322	64593322	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:64593322G>A	uc001xgm.2	+	73	13944	c.13714G>A	c.(13714-13716)GCT>ACT	p.A4572T	SYNE2_uc001xgl.2_Missense_Mutation_p.A4572T|SYNE2_uc010apy.2_Missense_Mutation_p.A957T|SYNE2_uc010apz.1_Missense_Mutation_p.A464T	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4572	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCAGACGCTGGCTCTTGAGTT	0.498000													6	216					0	0	0.001984	0	0	
PLEKHG3	26030	broad.mit.edu	37	14	65210268	65210268	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:65210268A>G	uc001xho.1	+	17	3776	c.3507A>G	c.(3505-3507)TCA>TCG	p.S1169S	PLEKHG3_uc001xhn.1_Silent_p.S1113S|PLEKHG3_uc001xhp.2_Silent_p.S1290S|PLEKHG3_uc010aqh.1_Silent_p.S711S|PLEKHG3_uc001xhq.1_Silent_p.S674S	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	1169					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GACCAAGCTCACCGGTGGCCC	0.662000													4	31					0	0	0.001984	0	0	
SPTB	6710	broad.mit.edu	37	14	65264532	65264532	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:65264532A>C	uc001xht.2	-	9	1151	c.1097T>G	c.(1096-1098)CTT>CGT	p.L366R	SPTB_uc001xhr.2_Missense_Mutation_p.L366R|SPTB_uc001xhs.2_Missense_Mutation_p.L366R|SPTB_uc001xhu.2_Missense_Mutation_p.L366R	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	366	Spectrin 1.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GATGGTAAAAAGTAGAACTTC	0.423000													30	140					0	0	0.008361	0	0	
NRXN3	9369	broad.mit.edu	37	14	79432563	79432563	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:79432563G>A	uc001xun.2	+	9	1963	c.1472G>A	c.(1471-1473)GGA>GAA	p.G491E	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.G616E	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	864	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCTCGTTTTGGACTGAGGAAC	0.468000													15	103					0	0	0.028581	0	0	
STON2	85439	broad.mit.edu	37	14	81864716	81864716	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:81864716A>G	uc010tvu.1	-	1	212	c.11T>C	c.(10-12)TTG>TCG	p.L4S	STON2_uc001xvk.1_Missense_Mutation_p.L4S|STON2_uc010atc.1_Missense_Mutation_p.L4S	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	4					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CACATGGTCCAAAGTCGTCAT	0.532000													3	45					0	0	0.009096	0	0	
FLRT2	23768	broad.mit.edu	37	14	86089254	86089254	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:86089254G>A	uc001xvr.2	+	2	2163	c.1396G>A	c.(1396-1398)GTT>ATT	p.V466I	FLRT2_uc010atd.2_Missense_Mutation_p.V466I	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	466	Fibronectin type-III.|Extracellular (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		AGGGGGCATCGTTCAGGAGCG	0.498000													11	162					0	0	0.008291	0	0	
KCNK13	56659	broad.mit.edu	37	14	90650597	90650597	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:90650597G>A	uc001xye.1	+	2	919	c.477G>A	c.(475-477)TCG>TCA	p.S159S		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	159	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TCATGAAGTCGTGCCACCAGC	0.602000													19	116					0	0	0.012319	0	0	
TRIP11	9321	broad.mit.edu	37	14	92488050	92488050	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:92488050G>A	uc001xzy.2	-	4	1226	c.438C>T	c.(436-438)TTC>TTT	p.F146F		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	146	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TCCCATAAGCGAATGAAGATG	0.448000			T	PDGFRB	AML								11	76					0	0	0.008291	0	0	
TRIP11	9321	broad.mit.edu	37	14	92491681	92491681	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:92491681A>C	uc001xzy.2	-	3	1073	c.285T>G	c.(283-285)AGT>AGG	p.S95R		NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	95	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		GATTTCGGTAACTTGTAGATT	0.294000			T	PDGFRB	AML								4	110					0	0	0.014758	0	0	
KIAA1409	57578	broad.mit.edu	37	14	94063712	94063712	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:94063712A>C	uc001ybv.1	+	21	2750	c.2667A>C	c.(2665-2667)AAA>AAC	p.K889N	KIAA1409_uc001ybs.1_Missense_Mutation_p.K889N	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1066						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CAGTGGAAAAAGTTGCTGTAA	0.423000													8	169					0	0	0.003080	0	0	
SETD3	84193	broad.mit.edu	37	14	99932051	99932051	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:99932051T>C	uc001ygc.2	-	2	262	c.92A>G	c.(91-93)GAG>GGG	p.E31G	SETD3_uc001ygd.2_Missense_Mutation_p.E31G|SETD3_uc001ygf.2_Missense_Mutation_p.E31G	NM_032233	NP_115609	Q86TU7	SETD3_HUMAN	SET domain containing 3 isoform a	31					peptidyl-lysine dimethylation|peptidyl-lysine monomethylation|peptidyl-lysine trimethylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone methyltransferase activity (H3-K36 specific)|transcription coactivator activity				0		all_cancers(154;0.224)|all_epithelial(191;0.0644)|Melanoma(154;0.0866)				CTGCAGCAGCTCACTGGTCAG	0.498000													4	90					0	0	0.009096	0	0	
MIR369	442914	broad.mit.edu	37	14	101531947	101531947	+	RNA	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:101531947C>T	hsa-mir-369|MI0000777	+			c.13C>T			uc010txp.1_RNA|MIR410_hsa-mir-410|MI0002465_5'Flank|MIR656_hsa-mir-656|MI0003678_5'Flank																	0						GAAGGGAGATCGACCGTGTTA	0.537000													22	157					0	0	0.012319	0	0	
AHNAK2	113146	broad.mit.edu	37	14	105419971	105419971	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr14:105419971G>T	uc010axc.1	-	7	1937	c.1817C>A	c.(1816-1818)ACA>AAA	p.T606K	AHNAK2_uc001ypx.2_Missense_Mutation_p.T506K	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	606						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGTGTCTTCTGTGGCTTTTTC	0.483000													39	596					6.99958e-10	7.322e-10	0.027894	1	0	
RTF1	23168	broad.mit.edu	37	15	41772842	41772842	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:41772842C>T	uc001zny.2	+	18	2102	c.2090C>T	c.(2089-2091)TCT>TTT	p.S697F		NM_015138	NP_055953	Q92541	RTF1_HUMAN	Paf1/RNA polymerase II complex component	697					histone modification|regulation of transcription, DNA-dependent|transcription initiation, DNA-dependent	nucleoplasm	protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(109;1.79e-19)|all_epithelial(112;8.18e-17)|Lung NSC(122;3.16e-11)|all_lung(180;8.14e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;1.15e-16)|GBM - Glioblastoma multiforme(113;1.81e-06)|BRCA - Breast invasive adenocarcinoma(123;0.119)		CCAAGGAGATCTCTGAACTTG	0.557000													7	55					0	0	0.004482	0	0	
MGA	23269	broad.mit.edu	37	15	42003309	42003309	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:42003309A>C	uc001zog.1	+	8	2937	c.2846A>C	c.(2845-2847)AAT>ACT	p.N949T	MGA_uc010ucy.1_Missense_Mutation_p.N949T|MGA_uc010ucz.1_Missense_Mutation_p.N949T	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	949						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ATCTCAGAAAATCAGGCGAAT	0.408000													16	215					0	0	0.028581	0	0	
MGA	23269	broad.mit.edu	37	15	42032110	42032110	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:42032110G>A	uc010uda.1	+	3	268	c.142G>A	c.(142-144)GGT>AGT	p.G48S	MGA_uc010ucy.1_Intron|MGA_uc010ucz.1_Intron	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1413						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TCAGGTTAATGGTAAGAGTTA	0.443000													24	207					0	0	0.027356	0	0	
SEMA6D	80031	broad.mit.edu	37	15	48056380	48056380	+	Silent	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:48056380T>A	uc010bek.2	+	11	1335	c.975T>A	c.(973-975)GGT>GGA	p.G325G	SEMA6D_uc001zvw.2_Silent_p.G325G|SEMA6D_uc001zvx.1_Silent_p.G325G|SEMA6D_uc001zvy.2_Silent_p.G325G|SEMA6D_uc001zvz.2_Silent_p.G325G|SEMA6D_uc001zwa.2_Silent_p.G325G|SEMA6D_uc001zwb.2_Silent_p.G325G|SEMA6D_uc001zwc.2_Silent_p.G325G	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	325	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GCATCCCTGGTTCTGCTGTCT	0.458000													4	144					0	0	0.009096	0	0	
MYEF2	50804	broad.mit.edu	37	15	48435171	48435171	+	Nonsense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:48435171G>T	uc001zwi.3	-	17	1861	c.1737C>A	c.(1735-1737)TGC>TGA	p.C579*	MYEF2_uc001zwg.3_Nonsense_Mutation_p.C117*|MYEF2_uc001zwh.3_Nonsense_Mutation_p.C167*|MYEF2_uc001zwj.3_Nonsense_Mutation_p.C555*	NM_016132	NP_057216	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	579	RRM 3.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			lung(2)|ovary(1)	3		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		TCATTATTCTGCAGGCTTTTT	0.393000													18	138					3.99206e-14	4.21983e-14	0.007413	1	0	
UNC13C	440279	broad.mit.edu	37	15	54786926	54786926	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:54786926A>C	uc002ack.2	+	18	5054	c.5054A>C	c.(5053-5055)TAC>TCC	p.Y1685S		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	1685	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GTTCCTGAATACTCCTTGTAA	0.353000													11	252					0	0	0.008291	0	0	
BBS4	585	broad.mit.edu	37	15	73029293	73029293	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:73029293C>T	uc002avb.2	+	15	1482	c.1439C>T	c.(1438-1440)ACG>ATG	p.T480M	BBS4_uc010ukv.1_Missense_Mutation_p.T468M|BBS4_uc002avc.2_Missense_Mutation_p.T308M|BBS4_uc002avd.2_Missense_Mutation_p.T488M	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	480	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						GCATACAGGACGCTCCCCTCA	0.522000									Bardet-Biedl_syndrome				16	139					0	0	0.024245	0	0	
CPEB1	64506	broad.mit.edu	37	15	83221347	83221347	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:83221347G>A	uc002bit.2	-	8	1415	c.1278C>T	c.(1276-1278)TTC>TTT	p.F426F	CPEB1_uc002biq.2_Silent_p.F286F|CPEB1_uc002bir.2_Silent_p.F291F|CPEB1_uc002bis.2_Silent_p.F286F|CPEB1_uc010uod.1_Silent_p.F135F|CPEB1_uc010uoe.1_Silent_p.F364F|CPEB1_uc002biu.2_Silent_p.F388F|CPEB1_uc010uof.1_Silent_p.F286F|CPEB1_uc002biv.2_Silent_p.F361F|CPEB1_uc002bip.2_Silent_p.F135F	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	366	RRM 1.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			TCTCTAGTTCGAAGACCAGAT	0.493000													11	72					0	0	0.013537	0	0	
AGBL1	123624	broad.mit.edu	37	15	87531292	87531292	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:87531292A>C	uc002blz.1	+	23	3238	c.3158A>C	c.(3157-3159)AAG>ACG	p.K1053T		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	1053					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						aactttttcaagatgaacctt	0.045000													40	282					0	0	0.007835	0	0	
WDR93	56964	broad.mit.edu	37	15	90244983	90244983	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr15:90244983A>C	uc002boj.2	+	2	107	c.6A>C	c.(4-6)TCA>TCC	p.S2S	WDR93_uc002bok.3_Silent_p.S2S|WDR93_uc010bnr.2_Silent_p.S2S	NM_020212	NP_064597	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	2					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			ovary(2)	2	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			CTGTGATGTCATTCCCAAGAG	0.458000													6	183					0	0	0.001984	0	0	
IFT140	9742	broad.mit.edu	37	16	1574665	1574665	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:1574665A>C	uc002cmb.2	-	24	3391	c.3029T>G	c.(3028-3030)CTG>CGG	p.L1010R	IFT140_uc002clz.2_Missense_Mutation_p.L623R	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1010	TPR 5.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				GGAGGCCGCCAGGTTTCCTGT	0.622000													6	61					0	0	0.001984	0	0	
TRAF7	84231	broad.mit.edu	37	16	2222327	2222327	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:2222327A>C	uc002cow.2	+	8	710	c.611A>C	c.(610-612)GAG>GCG	p.E204A		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	204					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						CCCATCTTTGAGGTGGACCCC	0.677000													8	30					0	0	0.006214	0	0	
ADCY9	115	broad.mit.edu	37	16	4016903	4016903	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:4016903C>T	uc002cvx.2	-	11	3474	c.2935G>A	c.(2935-2937)GGC>AGC	p.G979S		NM_001116	NP_001107	O60503	ADCY9_HUMAN	adenylate cyclase 9	979	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6						ACCTCCTGGCCGATGAGGCTG	0.582000													15	115					0	0	0.007413	0	0	
TNP2	7142	broad.mit.edu	37	16	11362947	11362947	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:11362947T>A	uc002das.2	-	1	214	c.173A>T	c.(172-174)AAC>ATC	p.N58I	C16orf75_uc002daq.1_Intron	NM_005425	NP_005416	Q05952	STP2_HUMAN	transition protein 2 (during histone to	58					cell differentiation|multicellular organismal development|spermatogenesis	nucleosome|nucleus	DNA binding				0						TCCAGTTGGGTTGCGGTGGCT	0.612000													6	125					0	0	0.001984	0	0	
TMC7	79905	broad.mit.edu	37	16	19041646	19041646	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:19041646G>T	uc002dfq.2	+	6	942	c.812G>T	c.(811-813)AGC>ATC	p.S271I	TMC7_uc010vao.1_Missense_Mutation_p.S271I|TMC7_uc002dfp.2_Missense_Mutation_p.S271I|TMC7_uc010vap.1_Missense_Mutation_p.S161I	NM_024847	NP_079123	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7 isoform a	271	Helical; (Potential).					integral to membrane				skin(2)|ovary(1)	3						TATTTGTTAAGCACAATCGCC	0.473000													21	165					2.32416e-17	2.46788e-17	0.014323	1	0	
GTF3C1	2975	broad.mit.edu	37	16	27492434	27492434	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:27492434C>T	uc002dov.1	-	27	4202	c.4162G>A	c.(4162-4164)GAA>AAA	p.E1388K	GTF3C1_uc002dou.2_Missense_Mutation_p.E1388K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1388						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TCTGGGATTTCAAGGTTAGAA	0.478000													19	182					0	0	0.008871	0	0	
SPN	6693	broad.mit.edu	37	16	29675643	29675643	+	Silent	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:29675643T>A	uc002dtm.2	+	2	730	c.594T>A	c.(592-594)ACT>ACA	p.T198T	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Silent_p.T198T|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	198	Extracellular (Potential).				blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						AGACCTCCACTGGGACCACTG	0.572000													5	299					0	0	0.021553	0	0	
MAZ	4150	broad.mit.edu	37	16	29818187	29818187	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:29818187C>T	uc002dty.2	+	1	333	c.165C>T	c.(163-165)TCC>TCT	p.S55S	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Silent_p.S32S|MAZ_uc010vdx.1_Silent_p.S32S|MAZ_uc002dtw.2_Silent_p.S55S|MAZ_uc002dtx.2_Silent_p.S55S|MAZ_uc010bzg.2_Silent_p.S55S|MAZ_uc002dtz.1_5'Flank|MAZ_uc002dua.2_5'Flank|MAZ_uc010vdy.1_5'Flank	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	55					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1						TCTTTGCCTCCCAGGGCTGCG	0.453000													3	29					0	0	0.004672	0	0	
NETO2	81831	broad.mit.edu	37	16	47143516	47143516	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:47143516T>G	uc002eer.1	-	7	1146	c.761A>C	c.(760-762)AAG>ACG	p.K254T	NETO2_uc002eeq.1_Missense_Mutation_p.K27T|NETO2_uc010vgf.1_Missense_Mutation_p.K111T|NETO2_uc002ees.1_Missense_Mutation_p.K247T	NM_018092	NP_060562	Q8NC67	NETO2_HUMAN	neuropilin- and tolloid-like protein 2	254	Extracellular (Potential).|CUB 2.					integral to membrane	receptor activity				0		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				GCTGCAAAACTTGGCCTTCAG	0.423000										HNSCC(25;0.065)			18	200					0	0	0.007413	0	0	
CMIP	80790	broad.mit.edu	37	16	81641288	81641288	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:81641288C>T	uc002fgp.2	+	2	489	c.417C>T	c.(415-417)GTC>GTT	p.V139V	CMIP_uc002fgq.1_Silent_p.V45V|CMIP_uc010vnq.1_5'Flank	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	105	PH.					cytoplasm|nucleus					0						GGGGAACTGTCTTACTGCAGG	0.498000													18	125					0	0	0.006122	0	0	
PLCG2	5336	broad.mit.edu	37	16	81944213	81944213	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:81944213A>C	uc002fgt.2	+	18	1974	c.1822A>C	c.(1822-1824)AGC>CGC	p.S608R	PLCG2_uc010chg.1_Missense_Mutation_p.S608R	NM_002661	NP_002652	P16885	PLCG2_HUMAN	phospholipase C, gamma 2	608	SH2 1.			TFSSI -> RFRRM (in Ref. 1; CAA32194/ AAA60112 and 3; AAQ76815).	intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			large_intestine(4)|lung(2)|ovary(1)|skin(1)	8						CCTCACCTTCAGCAGCATCTA	0.652000													8	289					0	0	0.003080	0	0	
USP10	9100	broad.mit.edu	37	16	84797843	84797843	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:84797843C>T	uc002fii.2	+	10	1948	c.1806C>T	c.(1804-1806)ATC>ATT	p.I602I	USP10_uc010voe.1_Silent_p.I606I|USP10_uc010vof.1_Silent_p.I164I|USP10_uc002fij.2_Silent_p.I128I	NM_005153	NP_005144	Q14694	UBP10_HUMAN	ubiquitin specific protease 10	602					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity				0						AGACTCCAATCACCGGCATTT	0.488000													38	177					0	0	0.008740	0	0	
FBXO31	79791	broad.mit.edu	37	16	87369863	87369863	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr16:87369863C>T	uc002fjw.2	-	6	784	c.740G>A	c.(739-741)CGG>CAG	p.R247Q	FBXO31_uc010vot.1_Missense_Mutation_p.R75Q|FBXO31_uc002fjv.2_Missense_Mutation_p.R139Q	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	247					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		CAGCCACGTCCGAAACTCCTT	0.547000													19	74					0	0	0.014323	0	0	
SMYD4	114826	broad.mit.edu	37	17	1703659	1703659	+	Silent	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:1703659T>A	uc002ftm.3	-	5	1197	c.1029A>T	c.(1027-1029)ACA>ACT	p.T343T	SMYD4_uc002ftn.1_Silent_p.T198T	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	343							zinc ion binding			skin(3)|kidney(2)	5						AGACACCCAGTGTGAGAAGCA	0.488000													27	144					0	0	0.024334	0	0	
OR1A1	8383	broad.mit.edu	37	17	3119805	3119805	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:3119805T>C	uc010vrc.1	+	1	891	c.891T>C	c.(889-891)GCT>GCC	p.A297A		NM_014565	NP_055380	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ACATGAAGGCTGCCCTGCGGA	0.438000													35	126					0	0	0.019004	0	0	
ALOX15	246	broad.mit.edu	37	17	4534935	4534935	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:4534935T>C	uc002fyh.2	-	14	1963	c.1949A>G	c.(1948-1950)TAC>TGC	p.Y650C	ALOX15_uc010vsd.1_Missense_Mutation_p.Y611C|ALOX15_uc010vse.1_Missense_Mutation_p.Y672C	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	650	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GGGCCGCAGGTACTCGTAGGG	0.567000													14	148					0	0	0.028581	0	0	
NUP88	4927	broad.mit.edu	37	17	5308509	5308509	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:5308509T>G	uc002gbo.1	-	6	938	c.912A>C	c.(910-912)GAA>GAC	p.E304D	NUP88_uc010vsx.1_Missense_Mutation_p.E304D|NUP88_uc010cle.1_Missense_Mutation_p.E303D|NUP88_uc010vsy.1_Missense_Mutation_p.E304D	NM_002532	NP_002523	Q99567	NUP88_HUMAN	nucleoporin 88kDa	304					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	transporter activity			kidney(1)	1						CATAGTTATCTTCAGCCGCAG	0.443000													12	84					0	0	0.013537	0	0	
CLEC10A	10462	broad.mit.edu	37	17	6978394	6978394	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:6978394C>T	uc002gek.2	-	9	1233	c.930G>A	c.(928-930)CAG>CAA	p.Q310Q	CLEC10A_uc002gej.2_Silent_p.Q286Q|CLEC10A_uc002gel.2_Silent_p.Q283Q|CLEC10A_uc010clv.1_3'UTR	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	310	Extracellular (Potential).				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						CCTGGCTGGTCTGACCCAGGC	0.637000													6	68					0	0	0.004482	0	0	
MYH10	4628	broad.mit.edu	37	17	8411923	8411923	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:8411923T>G	uc002gll.2	-	24	3166	c.3070A>C	c.(3070-3072)AAC>CAC	p.N1024H	MYH10_uc002glm.2_Missense_Mutation_p.N1055H|MYH10_uc010cnx.2_Missense_Mutation_p.N1033H	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1024	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						TTGGCCAAGTTTTTCGCCTTT	0.423000													7	371					0	0	0.003080	0	0	
MYH13	8735	broad.mit.edu	37	17	10215260	10215260	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:10215260T>C	uc002gmk.1	-	32	4589	c.4499A>G	c.(4498-4500)GAG>GGG	p.E1500G		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1500	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CCTCAGTGTCTCTAACTGGTC	0.542000													15	121					0	0	0.028581	0	0	
MED9	55090	broad.mit.edu	37	17	17394653	17394653	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:17394653G>A	uc002grh.1	+	2	341	c.285G>A	c.(283-285)CAG>CAA	p.Q95Q		NM_018019	NP_060489	Q9NWA0	MED9_HUMAN	mediator complex subunit 9	95					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		protein binding				0						GCAAGTTCCAGGAGATGCGCA	0.587000													16	116					0	0	0.004990	0	0	
LRRC48	83450	broad.mit.edu	37	17	17900913	17900913	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:17900913C>T	uc010vxd.1	+	10	1343	c.964C>T	c.(964-966)CGC>TGC	p.R322C	LRRC48_uc002gsa.2_Missense_Mutation_p.R322C|LRRC48_uc010vxc.1_Missense_Mutation_p.R322C|LRRC48_uc002gsb.2_Missense_Mutation_p.R322C|LRRC48_uc010vxe.1_RNA	NM_001130090	NP_001123562	Q9H069	LRC48_HUMAN	leucine rich repeat containing 48 isoform a	322						cytoplasm				pancreas(1)	1	all_neural(463;0.228)					GCAGGGCAAACGCAAGATTGC	0.567000													4	22					0	0	0.014758	0	0	
CYTSB	92521	broad.mit.edu	37	17	20108508	20108508	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:20108508A>C	uc002gwq.2	+	4	1291	c.1146A>C	c.(1144-1146)GAA>GAC	p.E382D	CYTSB_uc010cqx.2_Missense_Mutation_p.E382D|CYTSB_uc002gwr.2_Missense_Mutation_p.E382D|CYTSB_uc002gws.2_Missense_Mutation_p.E382D|CYTSB_uc002gwv.2_Missense_Mutation_p.E301D|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.E158D|CYTSB_uc002gwt.2_Missense_Mutation_p.E301D|CYTSB_uc002gwu.2_Missense_Mutation_p.E301D	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	382				E -> G (in Ref. 2; AAW29999/AAW30000/ AAW30002).		nucleus					0						AGATGGAAGAAAACCACCATA	0.438000													15	153					0	0	0.004990	0	0	
PROCA1	147011	broad.mit.edu	37	17	27031404	27031404	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:27031404T>G	uc002hcb.3	-	4	486	c.283A>C	c.(283-285)ACC>CCC	p.T95P	PROCA1_uc010crv.2_Missense_Mutation_p.T21P|PROCA1_uc002hca.1_Missense_Mutation_p.T93P	NM_152465	NP_689678	Q8NCQ7	PRCA1_HUMAN	protein interacting with cyclin A1	121					lipid catabolic process		calcium ion binding|phospholipase A2 activity			ovary(1)	1	Lung NSC(42;0.00431)					TGGGAGCAGGTTGGGCCCGCG	0.642000													35	210					0	0	0.019004	0	0	
TBC1D3	729873	broad.mit.edu	37	17	36375134	36375134	+	RNA	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:36375134T>G	uc010wdn.1	-	1		c.44A>C			uc002hpx.2_RNA			Q8IZP1	TBC3A_HUMAN	Homo sapiens TBC1D3 mRNA for TBC1 domain family, member 3, complete cds.							intracellular	Rab GTPase activator activity				0	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACAAGGTGACTTTTTCATCTT	0.358000													4	106					0	0	0.021553	0	0	
CDK12	51755	broad.mit.edu	37	17	37627139	37627139	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:37627139T>G	uc010cvv.2	+	2	1640	c.1054T>G	c.(1054-1056)TCC>GCC	p.S352A	CDK12_uc010wef.1_Missense_Mutation_p.S351A|CDK12_uc002hrw.3_Missense_Mutation_p.S352A	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	352					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.S352F(1)		ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						CAGTAGGAAATCCATGAAGTC	0.353000										TCGA Ovarian(9;0.13)			5	121					0	0	0.014758	0	0	
GRB7	2886	broad.mit.edu	37	17	37901697	37901697	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:37901697T>C	uc002hsr.2	+	11	1365	c.1115T>C	c.(1114-1116)CTG>CCG	p.L372P	GRB7_uc002hss.2_Missense_Mutation_p.L372P|GRB7_uc010cwc.2_Missense_Mutation_p.L372P|GRB7_uc002hst.2_Missense_Mutation_p.L372P	NM_005310	NP_005301	Q14451	GRB7_HUMAN	growth factor receptor-bound protein 7	372					blood coagulation|epidermal growth factor receptor signaling pathway|leukocyte migration|negative regulation of translation|positive regulation of cell migration|stress granule assembly	cytosol|focal adhesion|stress granule	phosphatidylinositol binding|protein kinase binding|SH3/SH2 adaptor activity			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;6.86e-60)|all cancers(3;1.65e-53)|BRCA - Breast invasive adenocarcinoma(8;2.03e-43)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATAATACCCTGGTGGCCATG	0.622000													19	95					0	0	0.007413	0	0	
KRT40	125115	broad.mit.edu	37	17	39140420	39140420	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:39140420C>T	uc010cxh.1	-	3	267	c.106G>A	c.(106-108)GGT>AGT	p.G36S	KRT40_uc002hvq.1_RNA	NM_182497	NP_872303	Q6A162	K1C40_HUMAN	type I hair keratin KA36	36	Head.					intermediate filament	structural molecule activity				0		Breast(137;0.00043)				GCACAGGTACCGGGGAGACAA	0.572000													19	74					0	0	0.007413	0	0	
KRTAP4-7	100132476	broad.mit.edu	37	17	39240908	39240908	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:39240908T>C	uc010wfn.1	+	1	450	c.450T>C	c.(448-450)TGT>TGC	p.C150C		NM_033061	NP_149050			keratin associated protein 4-7												0						CCTTGTGCTGTGCCTCCTCTT	0.567000													3	7					0	0	0.004672	0	0	
Unknown	0	broad.mit.edu	37	17	39296526	39296526	+	RNA	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:39296526T>C	uc010cxk.1	-	1		c.178A>G								Homo sapiens partial mRNA for keratin associated protein 4.6 (KRTAP4.6 gene).																		CAGCAGGTGGTCTgacagcag	0.537000													6	44					0	0	0.003080	0	0	
KRT34	3885	broad.mit.edu	37	17	39535633	39535633	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:39535633T>C	uc002hwm.2	-	5	986	c.974A>G	c.(973-975)GAG>GGG	p.E325G		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	325	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				CAGCTCGATCTCCAGGGCGTT	0.607000													18	132					0	0	0.007413	0	0	
RND2	8153	broad.mit.edu	37	17	41180175	41180175	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:41180175T>A	uc002icn.2	+	4	505	c.398T>A	c.(397-399)CTG>CAG	p.L133Q		NM_005440	NP_005431	P52198	RND2_HUMAN	Rho family GTPase 2 precursor	133					small GTPase mediated signal transduction	acrosomal membrane	GTP binding|GTPase activity				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		CTGAGGGAGCTGTCCAAGCAG	0.562000													7	84					0	0	0.003080	0	0	
SLC4A1	6521	broad.mit.edu	37	17	42338113	42338113	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:42338113C>T	uc002igf.3	-	5	388	c.239G>A	c.(238-240)CGC>CAC	p.R80H	SLC4A1_uc002igg.3_Missense_Mutation_p.R80H	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	80	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TTGCACCCAGCGCGCCGCCTC	0.617000													4	47					0	0	0.014758	0	0	
CCDC43	124808	broad.mit.edu	37	17	42756257	42756257	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:42756257T>G	uc002ihc.2	-	5	686	c.642A>C	c.(640-642)AAA>AAC	p.K214N	CCDC43_uc010czw.1_3'UTR	NM_144609	NP_653210	Q96MW1	CCD43_HUMAN	coiled-coil domain containing 43 isoform 1	214	Potential.										0		Prostate(33;0.0322)				GTGTCCTTTTTTTTTCCTTTT	0.473000													7	62					0	0	0.001984	0	0	
OSBPL7	114881	broad.mit.edu	37	17	45896428	45896428	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:45896428C>T	uc002ilx.1	-	5	496	c.293G>A	c.(292-294)CGG>CAG	p.R98Q	OSBPL7_uc002ilw.1_5'Flank	NM_145798	NP_665741	Q9BZF2	OSBL7_HUMAN	oxysterol-binding protein-like protein 7	98	PH.				lipid transport		lipid binding				0						GACCGACAGCCGGACATCGAT	0.557000													5	100					0	0	0.014758	0	0	
SNX11	29916	broad.mit.edu	37	17	46189961	46189961	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:46189961A>G	uc002inf.1	+	4	422	c.68A>G	c.(67-69)GAC>GGC	p.D23G	SNX11_uc010wlg.1_Missense_Mutation_p.D15G|SNX11_uc010wlh.1_Missense_Mutation_p.D15G|SNX11_uc010wli.1_5'UTR|SNX11_uc010wlj.1_Intron|SNX11_uc002ing.1_Missense_Mutation_p.D23G|SNX11_uc002inh.1_Missense_Mutation_p.D23G	NM_152244	NP_689450	Q9Y5W9	SNX11_HUMAN	sorting nexin 11	23	PX.				cell communication|protein transport	membrane	phosphatidylinositol binding				0						CGTGTTCAGGACCCCCGAGTG	0.488000													8	347					0	0	0.006214	0	0	
HOXB1	3211	broad.mit.edu	37	17	46607133	46607133	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:46607133G>A	uc002ink.1	-	2	688	c.682C>T	c.(682-684)CTG>TTG	p.L228L		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	228	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCCGGCTCAGGTACTTGTTG	0.572000													11	260					0	0	0.010729	0	0	
B4GALNT2	124872	broad.mit.edu	37	17	47241594	47241594	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:47241594T>C	uc002ion.2	+	8	1150	c.1091T>C	c.(1090-1092)ATT>ACT	p.I364T	B4GALNT2_uc010wlt.1_Missense_Mutation_p.I278T|B4GALNT2_uc010wlu.1_Missense_Mutation_p.I304T	NM_153446	NP_703147	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	364	Lumenal (Potential).				lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			large_intestine(1)|ovary(1)	2			all cancers(6;0.000316)			CCCCTGGAAATTAAAGACAAT	0.522000													5	191					0	0	0.001984	0	0	
DLX3	1747	broad.mit.edu	37	17	48069187	48069187	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:48069187T>G	uc002ipy.2	-	3	784	c.558A>C	c.(556-558)AAA>AAC	p.K186N		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	186	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCTTGTAGAGTTTCTTGAACT	0.532000													5	107					0	0	0.001984	0	0	
EPN3	55040	broad.mit.edu	37	17	48614290	48614290	+	Missense_Mutation	SNP	G	A	A	rs141972412		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:48614290G>A	uc002ira.3	+	2	808	c.373G>A	c.(373-375)GAG>AAG	p.E125K	EPN3_uc010wms.1_Missense_Mutation_p.E180K|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.E125K	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	125	ENTH.					clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CAACGTGCGCGAGAAGGTCAA	0.637000													9	69					0	0	0.008291	0	0	
DHX40	79665	broad.mit.edu	37	17	57652734	57652734	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:57652734T>G	uc002ixn.1	+	7	1022	c.875T>G	c.(874-876)CTT>CGT	p.L292R	DHX40_uc010woe.1_Missense_Mutation_p.L215R|DHX40_uc002ixo.1_Missense_Mutation_p.L193R	NM_024612	NP_078888	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	292	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TGTGAGTTACTTTTTCAGATG	0.318000													4	119					0	0	0.009096	0	0	
MRC2	9902	broad.mit.edu	37	17	60741993	60741993	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:60741993G>C	uc002jad.2	+	2	605	c.203G>C	c.(202-204)TGC>TCC	p.C68S	MRC2_uc002jac.2_Missense_Mutation_p.C68S	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	68	Extracellular (Potential).|Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						ACCCCGGCTTGCAATACCAGC	0.637000													7	113					0	0	0.003080	0	0	
ABCA5	23461	broad.mit.edu	37	17	67250625	67250625	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:67250625A>C	uc002jif.2	-	31	5293	c.4075T>G	c.(4075-4077)TTA>GTA	p.L1359V	ABCA5_uc002jib.2_Missense_Mutation_p.L325V|ABCA5_uc002jic.2_Missense_Mutation_p.L582V|ABCA5_uc002jid.2_Missense_Mutation_p.L276V|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.L1359V	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	1359	ABC transporter 2.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					TAATCTCCTAAAAATACCTAT	0.358000													3	105					0	0	0.009096	0	0	
KCNJ16	3773	broad.mit.edu	37	17	68129047	68129047	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:68129047A>C	uc002jin.2	+	5	1305	c.819A>C	c.(817-819)AAA>AAC	p.K273N	KCNJ16_uc002jio.2_Missense_Mutation_p.K273N|KCNJ16_uc002jip.2_Missense_Mutation_p.K273N|KCNJ16_uc002jiq.2_Missense_Mutation_p.K305N	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	273	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CAGTAGCCAAAGATAACTTTG	0.448000													48	288					0	0	0.014410	0	0	
C1QTNF1	114897	broad.mit.edu	37	17	77043792	77043793	+	Missense_Mutation	DNP	GC	AT	AT			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:77043792_77043793GC>AT	uc002jwp.2	+	4	808_809	c.468_469GC>AT	c.(466-471)ATGCAC>ATATAC	p.156_157MH>IY	C1QTNF1_uc002jwq.2_Missense_Mutation_p.74_75MH>IY|C1QTNF1_uc002jwr.3_Missense_Mutation_p.166_167MH>IY|C1QTNF1_uc002jws.2_Missense_Mutation_p.156_157MH>IY|C1QTNF1_uc002jwt.2_Missense_Mutation_p.254_255MH>IY	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	156_157	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			AGAAGCCCATGCACAGCAACCA	0.599000													4	69					0	0	0.004672	0	0	
RNF213	57674	broad.mit.edu	37	17	78324165	78324165	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr17:78324165A>T	uc002jyh.1	+	6	4595	c.4372A>T	c.(4372-4374)ATC>TTC	p.I1458F		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGAAGATGGAATCCGTAGCGC	0.353000													10	84					0	0	0.008291	0	0	
MAPRE2	10982	broad.mit.edu	37	18	32707044	32707044	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr18:32707044A>C	uc002kyg.2	+	5	923	c.743A>C	c.(742-744)AAT>ACT	p.N248T	MAPRE2_uc010xcb.1_Missense_Mutation_p.N205T|MAPRE2_uc010xcc.1_Missense_Mutation_p.N236T|MAPRE2_uc002kyf.2_Missense_Mutation_p.N248T|MAPRE2_uc002kyh.2_Missense_Mutation_p.N195T|MAPRE2_uc010xcd.1_Missense_Mutation_p.N205T	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	248	DCTN1-binding.|EB1 C-terminal.				cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						ATACAGCTTAATGAACAGGTA	0.527000													9	93					0	0	0.006214	0	0	
ZNF532	55205	broad.mit.edu	37	18	56587298	56587298	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr18:56587298A>G	uc002lho.2	+	4	2326	c.1779A>G	c.(1777-1779)CCA>CCG	p.P593P	ZNF532_uc002lhp.2_Silent_p.P591P|ZNF532_uc010xeg.1_Silent_p.P591P|ZNF532_uc002lhr.2_Silent_p.P591P|ZNF532_uc002lhs.2_Silent_p.P591P	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GTGTCAATCCAGTCCCTGTTT	0.557000													6	52					0	0	0.021553	0	0	
ZNF407	55628	broad.mit.edu	37	18	72344603	72344603	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr18:72344603T>C	uc002llw.2	+	1	1685	c.1628T>C	c.(1627-1629)TTG>TCG	p.L543S	ZNF407_uc010xfc.1_Missense_Mutation_p.L543S|ZNF407_uc010dqu.1_Missense_Mutation_p.L543S|ZNF407_uc002llu.2_Missense_Mutation_p.L542S	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	543	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		AGGACAGATTTGGAAATCCAT	0.463000													50	333					0	0	0.014410	0	0	
JSRP1	126306	broad.mit.edu	37	19	2252554	2252554	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:2252554T>G	uc002lvi.1	-	6	805	c.770A>C	c.(769-771)AAG>ACG	p.K257T	JSRP1_uc002lvj.1_Missense_Mutation_p.K257T	NM_144616	NP_653217	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	257	Arg-rich.					sarcoplasmic reticulum membrane				pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCTCTTTCTTAGGTCTCTC	0.706000													11	53					0	0	0.013537	0	0	
SPPL2B	56928	broad.mit.edu	37	19	2337467	2337467	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:2337467C>T	uc002lvs.2	+	3	292	c.212C>T	c.(211-213)ACG>ATG	p.T71M	SPPL2B_uc010dsw.1_Missense_Mutation_p.T43M|SPPL2B_uc010dsy.1_Missense_Mutation_p.T43M|SPPL2B_uc010dsz.1_Missense_Mutation_p.T71M|SPPL2B_uc002lvr.2_Missense_Mutation_p.T71M|SPPL2B_uc010dta.1_5'Flank|SPPL2B_uc002lvu.2_5'Flank	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	71	Cytoplasmic (Potential).|PA.					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCAACTGGACGGCCTCCCTG	0.642000													22	75					0	0	0.018920	0	0	
MAP2K2	5605	broad.mit.edu	37	19	4117551	4117551	+	Missense_Mutation	SNP	A	C	C	rs121434498		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:4117551A>C	uc002lzk.2	-	2	423	c.169T>G	c.(169-171)TTT>GTT	p.F57V		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	57			F -> C (in CFC syndrome).		activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGGTGAGAAAGGCTTCCAGC	0.597000									Cardiofaciocutaneous_syndrome				8	89					0	0	0.024245	0	0	
KDM4B	23030	broad.mit.edu	37	19	5135478	5135478	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:5135478G>A	uc002mbq.3	+	15	2440	c.2214G>A	c.(2212-2214)GAG>GAA	p.E738E	KDM4B_uc010xim.1_Silent_p.E772E|KDM4B_uc002mbr.3_Silent_p.E496E	NM_015015	NP_055830	O94953	KDM4B_HUMAN	jumonji domain containing 2B	738	PHD-type 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			lung(1)	1						CTGGCGGTGAGAACACGGAGC	0.637000													6	25					0	0	0.021553	0	0	
PTPRS	5802	broad.mit.edu	37	19	5244113	5244113	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:5244113T>C	uc002mbv.2	-	11	1603	c.1369A>G	c.(1369-1371)ATC>GTC	p.I457V	PTPRS_uc002mbu.1_Missense_Mutation_p.I444V|PTPRS_uc010xin.1_Missense_Mutation_p.I444V|PTPRS_uc002mbw.2_Missense_Mutation_p.I444V|PTPRS_uc002mbx.2_Missense_Mutation_p.I448V|PTPRS_uc002mby.2_Missense_Mutation_p.I444V	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	457	Extracellular (Potential).|Fibronectin type-III 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TAGCCGCGGATCAGGCCGTTG	0.682000													7	60					0	0	0.016723	0	0	
FBN3	84467	broad.mit.edu	37	19	8167646	8167646	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:8167646C>T	uc002mjf.2	-	39	5072	c.5051G>A	c.(5050-5052)TGG>TAG	p.W1684*		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1684	TB 7.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GGGTCTATTCCAGGCCTGGCC	0.542000													4	120					0	0	0.009096	0	0	
FBN3	84467	broad.mit.edu	37	19	8196690	8196690	+	Missense_Mutation	SNP	C	T	T	rs143761441		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:8196690C>T	uc002mjf.2	-	14	1759	c.1738G>A	c.(1738-1740)GGC>AGC	p.G580S		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	580	EGF-like 7; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						ACGCAGATGCCGGGCGTCTGG	0.552000													3	8					0	0	0.009096	0	0	
MUC16	94025	broad.mit.edu	37	19	9048508	9048508	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9048508C>T	uc002mkp.2	-	5	33327	c.33123G>A	c.(33121-33123)GTG>GTA	p.V11041V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11043	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGAGGTCACCACTCCTGGTA	0.488000													12	143					0	0	0.010729	0	0	
MUC16	94025	broad.mit.edu	37	19	9069337	9069337	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9069337C>T	uc002mkp.2	-	3	18313	c.18109G>A	c.(18109-18111)GGA>AGA	p.G6037R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6039	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTGTGTGTCCGGATGGCTGG	0.448000													38	312					0	0	0.008740	0	0	
MUC16	94025	broad.mit.edu	37	19	9076788	9076788	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9076788G>A	uc002mkp.2	-	3	10862	c.10658C>T	c.(10657-10659)ACC>ATC	p.T3553I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3554	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTTGGGTGTGGTAGTTGAGAT	0.547000													15	248					0	0	0.024245	0	0	
MUC16	94025	broad.mit.edu	37	19	9086693	9086693	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9086693T>G	uc002mkp.2	-	1	5326	c.5122A>C	c.(5122-5124)ACT>CCT	p.T1708P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1708	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCTTCAGTAGTTGACTCAGAA	0.488000													23	247					0	0	0.024334	0	0	
MUC16	94025	broad.mit.edu	37	19	9090185	9090185	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9090185T>C	uc002mkp.2	-	1	1834	c.1630A>G	c.(1630-1632)AAA>GAA	p.K544E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	544	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTCTCTGTTTTCATGCTAGGA	0.532000													5	128					0	0	0.014758	0	0	
ZNF560	147741	broad.mit.edu	37	19	9577597	9577597	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9577597T>G	uc002mlp.1	-	10	2236	c.2026A>C	c.(2026-2028)AAA>CAA	p.K676Q	ZNF560_uc010dwr.1_Missense_Mutation_p.K570Q	NM_152476	NP_689689	Q96MR9	ZN560_HUMAN	zinc finger protein 560	676	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|pancreas(1)|liver(1)	6						GCATGAGTTTTTAAGTGTTGA	0.358000													40	379					0	0	0.009718	0	0	
ZNF846	162993	broad.mit.edu	37	19	9868802	9868802	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9868802T>C	uc002mmb.1	-	6	1482	c.951A>G	c.(949-951)AAA>AAG	p.K317K	ZNF846_uc010xky.1_RNA|ZNF846_uc010xkz.1_RNA|ZNF846_uc010dww.2_Silent_p.K188K|ZNF846_uc002mmc.1_Silent_p.K188K	NM_001077624	NP_001071092	Q147U1	ZN846_HUMAN	zinc finger protein 846	317	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TAGTGAAGGCTTTTCCACATT	0.398000													27	211					0	0	0.024334	0	0	
OLFM2	93145	broad.mit.edu	37	19	9967528	9967528	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:9967528G>A	uc002mmp.2	-	5	670	c.642C>T	c.(640-642)TTC>TTT	p.F214F	OLFM2_uc002mmo.2_Silent_p.F136F	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	214	Olfactomedin-like.					extracellular region				large_intestine(1)|skin(1)	2						TCCAGGAGCCGAAGCGGGACC	0.652000													4	33					0	0	0.009096	0	0	
DNM2	1785	broad.mit.edu	37	19	10908118	10908118	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:10908118T>C	uc002mps.1	+	10	1423	c.1259T>C	c.(1258-1260)CTC>CCC	p.L420P	DNM2_uc010dxk.2_RNA|DNM2_uc002mpt.1_Intron|DNM2_uc002mpv.1_Missense_Mutation_p.L420P|DNM2_uc002mpu.1_Intron|DNM2_uc010dxl.1_Intron|DNM2_uc002mpw.2_Missense_Mutation_p.L153P	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	420					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			ATTGTAAAACTCAAAGAGCCG	0.502000													16	127					0	0	0.006122	0	0	
ZNF823	55552	broad.mit.edu	37	19	11832957	11832957	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:11832957A>G	uc002msm.2	-	4	1518	c.1392T>C	c.(1390-1392)ACT>ACC	p.T464T	ZNF823_uc010xmd.1_Silent_p.T282T|ZNF823_uc010dyi.1_Silent_p.T420T	NM_001080493	NP_001073962	P16415	ZN823_HUMAN	ZFP-36 for a zinc finger protein	464	C2H2-type 11; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTCCAGTGTGAGTTGTCTCAT	0.403000										HNSCC(68;0.2)			26	174					0	0	0.021523	0	0	
ZNF20	7568	broad.mit.edu	37	19	12246374	12246374	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:12246374T>C	uc002mtf.1	-	3	284	c.141A>G	c.(139-141)GGA>GGG	p.G47G	ZNF20_uc002mte.1_Silent_p.G12G|ZNF20_uc002mtg.1_Silent_p.G47G	NM_021143	NP_066966	P17024	ZNF20_HUMAN	zinc finger protein 20	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TCCATGTTTTTCCTAAAACAC	0.358000													10	101					0	0	0.013537	0	0	
ZNF564	163050	broad.mit.edu	37	19	12637395	12637395	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:12637395T>G	uc002mty.2	-	4	1737	c.1527A>C	c.(1525-1527)CAA>CAC	p.Q509H	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	509	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTTTCCACATTGCTTACATT	0.353000													31	202					0	0	0.009535	0	0	
DDX39	10212	broad.mit.edu	37	19	14521953	14521953	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:14521953T>A	uc010xnp.1	-	5	506	c.461A>T	c.(460-462)AAG>ATG	p.K154M	DDX39_uc002myo.2_Missense_Mutation_p.K154M|DDX39_uc010dzl.2_RNA|DDX39_uc010dzm.1_Missense_Mutation_p.K154M	NM_005804	NP_005795	O00148	DX39A_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39	154	Helicase ATP-binding.				mRNA export from nucleus|nuclear mRNA splicing, via spliceosome	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding				0						TTCATCCTTCTTGATGGAGAG	0.587000													5	247					0	0	0.014758	0	0	
EMR3	84658	broad.mit.edu	37	19	14758024	14758024	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:14758024T>C	uc002mzi.3	-	8	999	c.851A>G	c.(850-852)AAG>AGG	p.K284R	EMR3_uc010dzp.2_Missense_Mutation_p.K232R|EMR3_uc010xnv.1_Missense_Mutation_p.K158R	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	284	Extracellular (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						CGTCACAGACTTGGAGAGAGA	0.468000													12	340					0	0	0.020292	0	0	
TSSK6	83983	broad.mit.edu	37	19	19625642	19625642	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:19625642C>T	uc002nmr.2	-	1	828	c.595G>A	c.(595-597)GGC>AGC	p.G199S	TSSK6_uc002nmq.2_RNA|NDUFA13_uc002nms.2_5'Flank|NDUFA13_uc010xqx.1_5'Flank|NDUFA13_uc010xqy.1_5'Flank	NM_032037	NP_114426	Q9BXA6	TSSK6_HUMAN	testis-specific serine kinase 6	199	Protein kinase.				multicellular organismal development|sperm chromatin condensation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			stomach(1)	1						AGCACGACGCCCATGCTCCAC	0.657000													24	57					0	0	0.018920	0	0	
ZNF14	7561	broad.mit.edu	37	19	19822523	19822523	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:19822523T>G	uc002nnk.1	-	4	1721	c.1567A>C	c.(1567-1569)AAA>CAA	p.K523Q		NM_021030	NP_066358	P17017	ZNF14_HUMAN	zinc finger protein 14	523	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Renal(1328;0.0474)				GTGTGAATTTTTTCATGTTCT	0.408000													6	303					0	0	0.001984	0	0	
ZNF43	7594	broad.mit.edu	37	19	21991547	21991547	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:21991547C>T	uc002nqj.2	-	4	1422	c.1292G>A	c.(1291-1293)TGT>TAT	p.C431Y	ZNF43_uc010ecv.2_Missense_Mutation_p.C425Y|ZNF43_uc002nql.2_Missense_Mutation_p.C425Y|ZNF43_uc002nqm.2_Missense_Mutation_p.C425Y|ZNF43_uc002nqk.2_Missense_Mutation_p.C361Y	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	431	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GGCTTTGCCACATTCTTCACA	0.388000													10	216					0	0	0.006214	0	0	
ZNF208	7757	broad.mit.edu	37	19	22156857	22156857	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:22156857T>C	uc002nqp.2	-	4	1128	c.979A>G	c.(979-981)ACC>GCC	p.T327A	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTAATAAGGGTTGAGACCTTA	0.393000													47	74					0	0	0.014410	0	0	
ZNF257	113835	broad.mit.edu	37	19	22270892	22270892	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:22270892A>G	uc010ecx.2	+	4	509	c.340A>G	c.(340-342)AGA>GGA	p.R114G	ZNF257_uc010ecy.2_Missense_Mutation_p.R82G	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTACAATTAAGAAAGGGCTG	0.358000													12	86					0	0	0.010729	0	0	
ZNF181	339318	broad.mit.edu	37	19	35232041	35232041	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:35232041T>G	uc002nvu.3	+	4	1218	c.755T>G	c.(754-756)CTC>CGC	p.L252R	ZNF181_uc010xsa.1_Missense_Mutation_p.L251R|ZNF181_uc010xsb.1_Missense_Mutation_p.L251R|ZNF181_uc010xsc.1_Missense_Mutation_p.L187R	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	zinc finger protein 181 isoform 1	252	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CAGTCAATCCTCAATCGCCAC	0.448000													6	281					0	0	0.021553	0	0	
FFAR1	2864	broad.mit.edu	37	19	35842879	35842879	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:35842879T>G	uc002nzc.2	+	1	435	c.425T>G	c.(424-426)TTT>TGT	p.F142C		NM_005303	NP_005294	O14842	FFAR1_HUMAN	free fatty acid receptor 1	142	Helical; Name=4; (Potential).				energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)	1	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	GGTCTGGTCTTTGGGTTGGAG	0.662000													4	100					0	0	0.009096	0	0	
ZNF585A	199704	broad.mit.edu	37	19	37642537	37642537	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:37642537A>C	uc002ofo.1	-	5	2495	c.2264T>G	c.(2263-2265)TTC>TGC	p.F755C	ZNF585A_uc002ofm.1_Missense_Mutation_p.F700C|ZNF585A_uc002ofn.1_Missense_Mutation_p.F700C	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	755	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTCTGAACGAAGCCTTTCCC	0.488000													15	129					0	0	0.028581	0	0	
FCGBP	8857	broad.mit.edu	37	19	40366468	40366468	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:40366468A>G	uc002omp.3	-	30	13774	c.13766T>C	c.(13765-13767)CTG>CCG	p.L4589P		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4589	VWFD 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ATCGAAAGCCAGCGAGAGCCC	0.667000													12	60					0	0	0.020292	0	0	
ZNF780A	284323	broad.mit.edu	37	19	40580508	40580508	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:40580508T>C	uc002omy.2	-	6	2066	c.1841A>G	c.(1840-1842)GAA>GGA	p.E614G	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E614G|ZNF780A_uc010xvh.1_Missense_Mutation_p.E615G	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	614	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TTCCTTACATTCAAAGGGTTT	0.418000													25	256					0	0	0.018920	0	0	
CYP2B6	1555	broad.mit.edu	37	19	41518644	41518644	+	Silent	SNP	C	T	T	rs35661880	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:41518644C>T	uc002opr.1	+	8	1225	c.1218C>T	c.(1216-1218)GAC>GAT	p.D406D	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Silent_p.D206D	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	406					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AAAAACCAGACGCCTTCAATC	0.453000													90	327					0	0	0.014410	0	0	
CYP2A13	1553	broad.mit.edu	37	19	41596320	41596320	+	Missense_Mutation	SNP	G	A	A	rs146392271		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:41596320G>A	uc002opt.2	+	4	514	c.505G>A	c.(505-507)GAT>AAT	p.D169N		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	169					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	CGCCAATATCGATCCCACCTT	0.552000													10	126					0	0	0.020292	0	0	
ZNF223	7766	broad.mit.edu	37	19	44564948	44564948	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:44564948A>C	uc002oyf.1	+	4	442	c.189A>C	c.(187-189)GAA>GAC	p.E63D	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	63	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				TAAGGGAGGAAAAGTTTTGGA	0.398000													45	360					0	0	0.014410	0	0	
ZNF225	7768	broad.mit.edu	37	19	44636097	44636097	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:44636097G>A	uc002oyj.1	+	5	1573	c.1330G>A	c.(1330-1332)GAC>AAC	p.D444N	ZNF225_uc010eje.1_Missense_Mutation_p.D361N|ZNF225_uc010ejf.1_Missense_Mutation_p.D444N	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	zinc finger protein 225	444	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				GTTGGATCTTGACTTTCATCA	0.453000													13	133					0	0	0.016723	0	0	
ZFP112	7771	broad.mit.edu	37	19	44833807	44833807	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:44833807T>G	uc010ejj.2	-	5	634	c.521A>C	c.(520-522)TAT>TCT	p.Y174S	ZFP112_uc002ozc.3_Missense_Mutation_p.Y168S|ZFP112_uc010xwy.1_Missense_Mutation_p.Y191S|ZFP112_uc010xwz.1_Missense_Mutation_p.Y173S	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						CCAAGATGGATACCCTTGACT	0.368000													16	247					0	0	0.004990	0	0	
ZNF180	7733	broad.mit.edu	37	19	44981801	44981801	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:44981801T>G	uc002ozf.3	-	5	1179	c.897A>C	c.(895-897)AAA>AAC	p.K299N	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Missense_Mutation_p.K272N|ZNF180_uc002ozg.3_Missense_Mutation_p.K298N|ZNF180_uc010ejm.2_Missense_Mutation_p.K274N	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				AATCAAAGGTTTTTCCTCCTC	0.343000													8	218					0	0	0.004482	0	0	
ZNF180	7733	broad.mit.edu	37	19	44982338	44982338	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:44982338T>C	uc002ozf.3	-	5	642	c.360A>G	c.(358-360)AAA>AAG	p.K120K	ZNF180_uc002ozh.3_5'UTR|ZNF180_uc002ozi.3_Silent_p.K93K|ZNF180_uc002ozg.3_Silent_p.K119K|ZNF180_uc010ejm.2_Silent_p.K95K	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	120	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				AAGTTGAATCTTTTTTTCCAA	0.338000													12	110					0	0	0.010729	0	0	
PNMAL1	55228	broad.mit.edu	37	19	46973452	46973452	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:46973452T>G	uc002peq.3	-	2	1147	c.841A>C	c.(841-843)AGC>CGC	p.S281R	PNMAL1_uc002per.3_Missense_Mutation_p.S281R	NM_018215	NP_060685	Q86V59	PNML1_HUMAN	PNMA-like 1 isoform a	281											0		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ATCGCCATGCTTTCAGCATCA	0.527000													17	327					0	0	0.004990	0	0	
DHDH	27294	broad.mit.edu	37	19	49447725	49447725	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:49447725A>T	uc002ple.1	+	6	896	c.856A>T	c.(856-858)AGT>TGT	p.S286C		NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase	286					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		GGCAGGCATGAGTTATGAGGC	0.627000													13	97					0	0	0.020292	0	0	
NR1H2	7376	broad.mit.edu	37	19	50881883	50881883	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:50881883T>C	uc010enw.2	+	7	856	c.580T>C	c.(580-582)TCA>CCA	p.S194P	NR1H2_uc002prv.3_RNA|NR1H2_uc002prz.3_Missense_Mutation_p.S193P|NR1H2_uc002psa.3_Missense_Mutation_p.S96P	NM_007121	NP_009052	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	193	Poly-Ser.				negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		CAGCAGCAGCTCAGCCTCTGG	0.607000													5	24					0	0	0.006214	0	0	
ZNF880	400713	broad.mit.edu	37	19	52888022	52888022	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:52888022A>G	uc002pzc.2	+	4	1238	c.1189A>G	c.(1189-1191)AAT>GAT	p.N397D		NM_001145434	NP_001138906	Q6PDB4	ZN880_HUMAN	zinc finger protein LOC400713	397	C2H2-type 8.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						TTGTCTAACCAATCATCATAG	0.403000													4	76					0	0	0.014758	0	0	
ZNF808	388558	broad.mit.edu	37	19	53057134	53057134	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:53057134A>C	uc010epq.1	+	5	1142	c.965A>C	c.(964-966)AAG>ACG	p.K322T	ZNF808_uc002pzq.2_RNA|ZNF808_uc010epr.1_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	322	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		GAGTGTGGCAAGGTCTTTCGT	0.383000													30	248					0	0	0.009535	0	0	
ZNF160	90338	broad.mit.edu	37	19	53571418	53571418	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:53571418T>G	uc010eqk.2	-	7	2785	c.2369A>C	c.(2368-2370)AAA>ACA	p.K790T	ZNF160_uc002qaq.3_Missense_Mutation_p.K790T|ZNF160_uc002qar.3_Missense_Mutation_p.K790T	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	790	C2H2-type 20.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		CTCATTACATTTGTAACGCTT	0.448000													30	247					0	0	0.008361	0	0	
ZNF677	342926	broad.mit.edu	37	19	53741755	53741755	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:53741755C>A	uc002qbf.1	-	5	410	c.225G>T	c.(223-225)GAG>GAT	p.E75D	ZNF677_uc002qbg.1_Missense_Mutation_p.E75D	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	75	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		GGTATAATTCCTCTTTATTAT	0.348000													24	161					6.44725e-10	6.75426e-10	0.014323	1	0	
PRPF31	26121	broad.mit.edu	37	19	54627955	54627955	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:54627955C>T	uc002qdh.2	+	8	1171	c.775C>T	c.(775-777)CTG>TTG	p.L259L	PRPF31_uc010yek.1_Silent_p.L259L	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	259	Nop.				assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCGCAAGACGCTGTCGGGCTT	0.652000													5	65					0	0	0.001984	0	0	
KIR3DL1	3811	broad.mit.edu	37	19	55341674	55341674	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:55341674T>G	uc002qhk.3	+	9	1342	c.1279T>G	c.(1279-1281)TTG>GTG	p.L427V	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Missense_Mutation_p.L352V|KIR3DL1_uc010esf.2_Missense_Mutation_p.L332V|KIR3DL1_uc010yfo.1_Missense_Mutation_p.L369V|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_5'Flank|KIR2DS4_uc002qhm.1_5'Flank	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	427	Cytoplasmic (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		AGATACCATCTTGTACACGGA	0.512000													14	496					0	0	0.028581	0	0	
KIR2DS4	3809	broad.mit.edu	37	19	55349282	55349282	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:55349282C>A	uc002qhm.1	+	3	368	c.322C>A	c.(322-324)CCC>ACC	p.P108T	KIR2DS4_uc010yfj.1_Missense_Mutation_p.P101T|KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Missense_Mutation_p.P108T|KIR2DS4_uc002qhn.1_Missense_Mutation_p.P55T	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	108	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		TCCTCACTCCCCCTATCAGTT	0.507000													56	692					2.41709e-19	2.57044e-19	0.014410	1	0	
BRSK1	84446	broad.mit.edu	37	19	55813018	55813018	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:55813018A>C	uc002qkg.2	+	8	1094	c.817A>C	c.(817-819)AGG>CGG	p.R273R	BRSK1_uc002qkf.2_Silent_p.R289R|BRSK1_uc002qkh.2_5'Flank	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	273	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GCCCGAAAAAAGGCTCAGTGT	0.577000													4	19					0	0	0.014758	0	0	
NLRP9	338321	broad.mit.edu	37	19	56243492	56243492	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:56243492A>C	uc002qly.2	-	2	1733	c.1705T>G	c.(1705-1707)TTC>GTC	p.F569V		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	569						cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ATATAAATGAAAACTTCTTCA	0.343000													5	124					0	0	0.014758	0	0	
ZNF211	10520	broad.mit.edu	37	19	58152729	58152729	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr19:58152729A>G	uc002qpq.2	+	3	1055	c.875A>G	c.(874-876)AAA>AGA	p.K292R	ZNF211_uc010yhb.1_Missense_Mutation_p.K296R|ZNF211_uc002qpp.2_Missense_Mutation_p.K305R|ZNF211_uc002qpr.2_Missense_Mutation_p.K356R|ZNF211_uc002qps.2_Missense_Mutation_p.K357R|ZNF211_uc002qpt.2_Missense_Mutation_p.K304R|ZNF211_uc010yhc.1_Missense_Mutation_p.K304R|ZNF211_uc010yhd.1_Missense_Mutation_p.K231R|ZNF211_uc010yhe.1_Missense_Mutation_p.K283R	NM_198855	NP_942152	Q13398	ZN211_HUMAN	zinc finger protein 211 isoform 2	292	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GAATGTGGAAAATTCTTTACC	0.413000													20	155					0	0	0.010504	0	0	
TPO	7173	broad.mit.edu	37	2	1507813	1507813	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:1507813A>T	uc002qww.2	+	14	2571	c.2480A>T	c.(2479-2481)GAC>GTC	p.D827V	TPO_uc010ewj.2_RNA|TPO_uc002qwu.2_Missense_Mutation_p.D770V|TPO_uc002qwr.2_Missense_Mutation_p.D827V|TPO_uc002qwx.2_Missense_Mutation_p.D770V|TPO_uc010yio.1_Missense_Mutation_p.D654V|TPO_uc010yip.1_Intron|TPO_uc002qwy.1_Intron|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	827	Extracellular (Potential).|EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CTCTGCGCGGACCCCTACGAG	0.572000													16	66					0	0	0.004990	0	0	
TAF1B	9014	broad.mit.edu	37	2	10074061	10074061	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:10074061A>C	uc002qzz.2	+	15	1815	c.1715A>C	c.(1714-1716)AAA>ACA	p.K572T	TAF1B_uc010yja.1_Missense_Mutation_p.K317T|TAF1B_uc010exd.2_Missense_Mutation_p.K317T	NM_005680	NP_005671	Q53T94	TAF1B_HUMAN	TBP-associated factor 1B	572					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|breast(1)|pancreas(1)	3	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTTGAGAAAAAATACAGTGTA	0.303000													14	81					0	0	0.020292	0	0	
ODC1	4953	broad.mit.edu	37	2	10584276	10584276	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:10584276T>C	uc010exg.1	-	5	828	c.394A>G	c.(394-396)ACT>GCT	p.T132A	ODC1_uc002ran.1_5'Flank|ODC1_uc002rao.1_Missense_Mutation_p.T132A|ODC1_uc010yjd.1_Missense_Mutation_p.T2A	NM_002539	NP_002530	P11926	DCOR_HUMAN	ornithine decarboxylase 1	132					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	CTATCAAAAGTCATCATCTGG	0.428000													13	663					0	0	0.020292	0	0	
APOB	338	broad.mit.edu	37	2	21225959	21225959	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:21225959G>T	uc002red.2	-	29	12463	c.12335C>A	c.(12334-12336)GCT>GAT	p.A4112D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4112					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACCCACTCAGCATTGTTCTG	0.488000													40	403					8.69298e-16	9.21665e-16	0.027894	1	0	
APOB	338	broad.mit.edu	37	2	21233516	21233516	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:21233516T>A	uc002red.2	-	26	6352	c.6224A>T	c.(6223-6225)GAG>GTG	p.E2075V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2075	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGCAAGGTCTCAAAAAATGG	0.353000													7	239					0	0	0.001984	0	0	
APOB	338	broad.mit.edu	37	2	21233884	21233884	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:21233884A>T	uc002red.2	-	26	5984	c.5856T>A	c.(5854-5856)CAT>CAA	p.H1952Q		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1952					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACACGAGATGATGACTTGTGG	0.478000													14	322					0	0	0.020292	0	0	
APOB	338	broad.mit.edu	37	2	21234742	21234742	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:21234742C>T	uc002red.2	-	26	5126	c.4998G>A	c.(4996-4998)GTG>GTA	p.V1666V		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1666					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CATTCTCCAGCACCAGGAGAC	0.463000													6	121					0	0	0.021553	0	0	
ITSN2	50618	broad.mit.edu	37	2	24523025	24523025	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:24523025T>G	uc002rfe.2	-	12	1355	c.1097A>C	c.(1096-1098)AAA>ACA	p.K366T	ITSN2_uc002rff.2_Missense_Mutation_p.K366T|ITSN2_uc002rfg.2_Missense_Mutation_p.K366T|ITSN2_uc010eyd.2_Missense_Mutation_p.K391T	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	366	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCTTTCCGTTTGTCCTCAAA	0.458000													29	279					0	0	0.008361	0	0	
NLRC4	58484	broad.mit.edu	37	2	32476658	32476658	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:32476658T>A	uc002roi.2	-	4	521	c.275A>T	c.(274-276)CAG>CTG	p.Q92L	NLRC4_uc002roj.1_Missense_Mutation_p.Q92L|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	92					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TTCTGATGTCTGATGAAAAAG	0.438000													15	157					0	0	0.028581	0	0	
YIPF4	84272	broad.mit.edu	37	2	32526534	32526534	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:32526534A>G	uc002rok.2	+	5	834	c.567A>G	c.(565-567)GGA>GGG	p.G189G		NM_032312	NP_115688	Q9BSR8	YIPF4_HUMAN	Yip1 domain family, member 4	189						endoplasmic reticulum|integral to membrane	protein binding				0	Acute lymphoblastic leukemia(172;0.155)					TGGTGGTTGGATCATTTGAAG	0.348000													23	245					0	0	0.016522	0	0	
BIRC6	57448	broad.mit.edu	37	2	32678936	32678936	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:32678936T>C	uc010ezu.2	+	23	4813	c.4679T>C	c.(4678-4680)CTT>CCT	p.L1560P		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1560					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					CTCACTGGACTTTTGGAAGTT	0.398000													29	315					0	0	0.008361	0	0	
TTC27	55622	broad.mit.edu	37	2	32855667	32855667	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:32855667T>C	uc002rom.2	+	2	397	c.166T>C	c.(166-168)TTT>CTT	p.F56L	TTC27_uc010ymx.1_Missense_Mutation_p.F6L	NM_017735	NP_060205	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	56							protein binding			central_nervous_system(1)	1						TCAAAATATTTTTAATTCAAC	0.358000													5	119					0	0	0.021553	0	0	
PLEKHH2	130271	broad.mit.edu	37	2	43924480	43924480	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:43924480G>A	uc010yny.1	+	7	756	c.673G>A	c.(673-675)GGA>AGA	p.G225R	PLEKHH2_uc002rte.3_Missense_Mutation_p.G225R|PLEKHH2_uc002rtf.3_Missense_Mutation_p.G224R	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	225						cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GTTCACTGAAGGAAAAGACAT	0.358000													13	113					0	0	0.016723	0	0	
PREPL	9581	broad.mit.edu	37	2	44549015	44549015	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:44549015A>T	uc002ruf.2	-	13	2080	c.2045T>A	c.(2044-2046)CTA>CAA	p.L682Q	PREPL_uc002rug.2_Missense_Mutation_p.L616Q|PREPL_uc002ruh.2_Missense_Mutation_p.L620Q|PREPL_uc010fax.2_Missense_Mutation_p.L682Q|PREPL_uc002rui.3_Missense_Mutation_p.L593Q|PREPL_uc002ruj.1_Missense_Mutation_p.L593Q|PREPL_uc002ruk.1_Missense_Mutation_p.L682Q	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	682					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGAATATCTAGAATAATATT	0.413000													6	158					0	0	0.021553	0	0	
SOCS5	9655	broad.mit.edu	37	2	46986354	46986354	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:46986354A>C	uc002rvf.2	+	2	849	c.685A>C	c.(685-687)AAA>CAA	p.K229Q	SOCS5_uc010yoe.1_Missense_Mutation_p.K198Q|SOCS5_uc002rvg.2_Missense_Mutation_p.K229Q	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	229					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TTTAGCCCAAAAATGGCATTT	0.378000													5	195					0	0	0.014758	0	0	
FSHR	2492	broad.mit.edu	37	2	49191026	49191026	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:49191026A>T	uc002rww.2	-	10	1008	c.934T>A	c.(934-936)TCC>ACC	p.S312T	FSHR_uc002rwx.2_Missense_Mutation_p.S250T|FSHR_uc010fbn.2_Missense_Mutation_p.S286T	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	312	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GCCAGAGAGGATCTCTGACCC	0.403000									Gonadal_Dysgenesis_46_XX				6	348					0	0	0.003080	0	0	
SPTBN1	6711	broad.mit.edu	37	2	54872493	54872493	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:54872493A>C	uc002rxu.2	+	21	4646	c.4397A>C	c.(4396-4398)AAG>ACG	p.K1466T	SPTBN1_uc002rxx.2_Missense_Mutation_p.K1453T	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1466	Spectrin 12.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GTGCAGACCAAGTTCATGGAG	0.557000													17	162					0	0	0.004990	0	0	
REL	5966	broad.mit.edu	37	2	61145345	61145345	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:61145345A>C	uc002sam.1	+	6	779	c.555A>C	c.(553-555)GAA>GAC	p.E185D	REL_uc002san.1_Missense_Mutation_p.E185D	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	185	RHD.				positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			ATACTGCAGAATTAAGGATTT	0.308000			A		Hodgkin Lymphoma								9	76					0	0	0.004482	0	0	
ZNF638	27332	broad.mit.edu	37	2	71654264	71654264	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:71654264T>C	uc002shx.2	+	24	5584	c.5265T>C	c.(5263-5265)ACT>ACC	p.T1755T	ZNF638_uc002shy.2_Silent_p.T1755T|ZNF638_uc002shz.2_Silent_p.T1755T|ZNF638_uc002sia.2_Silent_p.T1755T|ZNF638_uc002sib.1_3'UTR|ZNF638_uc010fed.2_Intron|ZNF638_uc002sic.2_Silent_p.T852T|ZNF638_uc002sid.2_Silent_p.T124T	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	1755					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						ATGAAGTAACTGAAGAGGATG	0.388000													7	308					0	0	0.001984	0	0	
HK2	3099	broad.mit.edu	37	2	75104388	75104388	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:75104388T>G	uc002snd.2	+	8	2897	c.971T>G	c.(970-972)CTC>CGC	p.L324R		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	324	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						GGGGGGAAGCTCAGCCCAGAG	0.547000													12	521					0	0	0.010729	0	0	
ANKRD20B	729171	broad.mit.edu	37	2	95464636	95464636	+	RNA	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:95464636A>G	uc010fhp.2	-	17		c.2754T>C				NR_003366				Homo sapiens ankyrin repeat domain 20B (ANKRD20B), non-coding RNA.												0						ATCCTCCTCAAGTTTTTCATT	0.289000													23	70					0	0	0.014323	0	0	
Unknown	0	broad.mit.edu	37	2	95558407	95558407	+	RNA	SNP	A	G	G	rs5006801		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:95558407A>G	uc002stv.1	-	6		c.594T>C								Homo sapiens cDNA FLJ44118 fis, clone TESTI4047069.																		CTCAAAACAGAATGCATCTGG	0.463000													3	53					0	0	0.009096	0	0	
CHST10	9486	broad.mit.edu	37	2	101023091	101023091	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:101023091A>G	uc002tam.2	-	3	406	c.47T>C	c.(46-48)TTC>TCC	p.F16S		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	16	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						CATGAACATGAAAATCACCCA	0.478000													4	372					0	0	0.009096	0	0	
NPAS2	4862	broad.mit.edu	37	2	101582145	101582145	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:101582145T>A	uc002tap.1	+	10	1110	c.824T>A	c.(823-825)CTG>CAG	p.L275Q	NPAS2_uc010yvt.1_Missense_Mutation_p.L340Q	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	275	PAS 2.				central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						ATAGGATACCTGCCTTTTGAA	0.562000													5	245					0	0	0.021553	0	0	
SLC9A2	6549	broad.mit.edu	37	2	103281748	103281748	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:103281748T>G	uc002tca.2	+	3	1085	c.943T>G	c.(943-945)TTC>GTC	p.F315V		NM_003048	NP_003039	Q9UBY0	SL9A2_HUMAN	solute carrier family 9 (sodium/hydrogen	315	Helical; Name=I/M7; (Potential).					integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			central_nervous_system(3)|skin(3)|breast(2)	8						ACTGTTTGTTTTCCTGTACAG	0.443000													18	217					0	0	0.027356	0	0	
RGPD4	285190	broad.mit.edu	37	2	108476224	108476224	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:108476224A>C	uc010ywk.1	+	12	1763	c.1681A>C	c.(1681-1683)AAC>CAC	p.N561H	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	561					intracellular transport		binding			skin(2)	2						GCATGAAATAAACACTCTAAG	0.358000													15	204					0	0	0.008871	0	0	
RANBP2	5903	broad.mit.edu	37	2	109371385	109371385	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:109371385A>C	uc002tem.3	+	16	2353	c.2227A>C	c.(2227-2229)AAA>CAA	p.K743Q		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	743					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						GGAGTCTGTAAAAGAGATGCT	0.333000													52	434					0	0	0.014410	0	0	
THSD7B	80731	broad.mit.edu	37	2	138033526	138033526	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:138033526A>G	uc002tva.1	+	11	2337	c.2337A>G	c.(2335-2337)TTA>TTG	p.L779L	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.L669L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTTGCATCTTAGTGCCAGAGT	0.418000													5	59					0	0	0.014758	0	0	
LRP1B	53353	broad.mit.edu	37	2	141032079	141032079	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:141032079T>A	uc002tvj.1	-	85	14028	c.13056A>T	c.(13054-13056)GAA>GAT	p.E4352D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4352	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTTTGGTCCTTCATAGCGCG	0.428000										TSP Lung(27;0.18)			22	188					0	0	0.012319	0	0	
LRP1B	53353	broad.mit.edu	37	2	141128301	141128301	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:141128301A>G	uc002tvj.1	-	71	11958	c.10986T>C	c.(10984-10986)AGT>AGC	p.S3662S		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3662	Extracellular (Potential).|LDL-receptor class A 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTCTTCATCACTGCCATCCA	0.398000										TSP Lung(27;0.18)			44	479					0	0	0.014410	0	0	
RIF1	55183	broad.mit.edu	37	2	152319680	152319680	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:152319680A>T	uc002txm.2	+	30	3776	c.3646A>T	c.(3646-3648)AGT>TGT	p.S1216C	RIF1_uc002txl.2_Missense_Mutation_p.S1216C|RIF1_uc002txn.2_Missense_Mutation_p.S1216C|RIF1_uc002txo.2_Missense_Mutation_p.S1216C|RIF1_uc002txp.2_RNA	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	1216					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ATACCCTACAAGTCGGAGGCA	0.388000													9	243					0	0	0.004482	0	0	
NEB	4703	broad.mit.edu	37	2	152573961	152573961	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:152573961A>C	uc010fnx.2	-	10	982	c.791T>G	c.(790-792)TTT>TGT	p.F264C		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	264	Nebulin 6.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTTCTTGGCAAATTCTATATC	0.423000													5	68					0	0	0.021553	0	0	
LY75	4065	broad.mit.edu	37	2	160706613	160706613	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:160706613A>C	uc002ubc.3	-	23	3097	c.3028T>G	c.(3028-3030)TTA>GTA	p.L1010V	LY75_uc002ubb.3_Missense_Mutation_p.L1010V|LY75_uc010fos.2_Missense_Mutation_p.L1010V	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1010	Extracellular (Potential).|C-type lectin 6.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		CCAATCCATAAAGTAGCTTCC	0.338000													4	107					0	0	0.021553	0	0	
SLC38A11	151258	broad.mit.edu	37	2	165796034	165796034	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:165796034A>C	uc002ucv.1	-	7	832	c.295T>G	c.(295-297)TTC>GTC	p.F99V	SLC38A11_uc002ucu.1_Missense_Mutation_p.F77V|SLC38A11_uc002ucw.1_Missense_Mutation_p.F99V	NM_173512	NP_775783	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	99	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane		p.L99H(1)		ovary(1)	1						CCAATAATGAAGTGGCGACCA	0.333000													16	143					0	0	0.006122	0	0	
CSRNP3	80034	broad.mit.edu	37	2	166451672	166451672	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:166451672A>C	uc002udf.2	+	4	473	c.97A>C	c.(97-99)AGT>CGT	p.S33R	CSRNP3_uc002udg.2_Missense_Mutation_p.S33R	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	33	Ser-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						CAGCAGTGAAAGTGCTGACAG	0.453000													33	178					0	0	0.017118	0	0	
XIRP2	129446	broad.mit.edu	37	2	168099931	168099931	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:168099931G>A	uc002udx.2	+	8	2047	c.2029G>A	c.(2029-2031)GCG>ACG	p.A677T	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.A502T|XIRP2_uc010fpq.2_Missense_Mutation_p.A455T|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	502					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGAAGAATCAGCGGTAACTAT	0.433000													28	134					0	0	0.007291	0	0	
B3GALT1	8708	broad.mit.edu	37	2	168725733	168725733	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:168725733T>G	uc002udz.1	+	2	535	c.184T>G	c.(184-186)TCT>GCT	p.S62A		NM_020981	NP_066191	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta	62	Lumenal (Potential).				lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4						CAACCCACATTCTTTTGAATT	0.408000													38	181					0	0	0.019004	0	0	
KLHL23	151230	broad.mit.edu	37	2	170592685	170592685	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:170592685G>C	uc002ufh.1	+	4	1499	c.1161G>C	c.(1159-1161)GAG>GAC	p.E387D	KLHL23_uc002ufi.1_Missense_Mutation_p.E387D	NM_144711	NP_653312	Q8NBE8	KLH23_HUMAN	kelch-like 23	387	Kelch 3.										0						AAGAGGCTGAGTTCTATGATC	0.403000													61	225					0	0	0.014410	0	0	
MYO3B	140469	broad.mit.edu	37	2	171073866	171073866	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:171073866A>G	uc002ufy.2	+	6	707	c.564A>G	c.(562-564)AGA>AGG	p.R188R	MYO3B_uc002ufv.2_Silent_p.R175R|MYO3B_uc010fqb.1_Silent_p.R175R|MYO3B_uc002ufz.2_Silent_p.R188R|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002uga.2_Silent_p.R175R	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	188	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						GTCTGCGGAGAAACACATCTG	0.423000													56	432					0	0	0.014410	0	0	
DCAF17	80067	broad.mit.edu	37	2	172336628	172336628	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:172336628A>G	uc002ugx.2	+	13	1576	c.1347A>G	c.(1345-1347)AAA>AAG	p.K449K	DCAF17_uc010zdq.1_RNA|DCAF17_uc010fqf.1_Silent_p.K382K|DCAF17_uc010zdr.1_RNA|DCAF17_uc010fqg.2_Silent_p.K169K	NM_025000	NP_079276	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17 isoform 1	449						CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus					0						CTGAAGGAAAAGCTCACCTGG	0.383000													6	192					0	0	0.021553	0	0	
SLC25A12	8604	broad.mit.edu	37	2	172683315	172683315	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:172683315T>C	uc002uhh.2	-	9	1012	c.923A>G	c.(922-924)CAG>CGG	p.Q308R	SLC25A12_uc010fqh.2_Missense_Mutation_p.Q201R	NM_003705	NP_003696	O75746	CMC1_HUMAN	solute carrier family 25, member 12	308					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	TACCTGTCTCTGAAGTTCTGC	0.398000													4	117					0	0	0.009096	0	0	
HAT1	8520	broad.mit.edu	37	2	172822019	172822019	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:172822019T>G	uc002uhi.2	+	5	546	c.470T>G	c.(469-471)TTT>TGT	p.F157C	HAT1_uc010fqi.2_5'UTR|HAT1_uc002uhj.2_Missense_Mutation_p.F72C	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	157					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GGAGAAAACTTTACCTTTCAG	0.323000													3	111					0	0	0.004672	0	0	
TTN	7273	broad.mit.edu	37	2	179435725	179435725	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:179435725T>A	uc010zfg.1	-	275	67654	c.67430A>T	c.(67429-67431)AAG>ATG	p.K22477M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K16172M|TTN_uc010zfi.1_Missense_Mutation_p.K16105M|TTN_uc010zfj.1_Missense_Mutation_p.K15980M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23404							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATTCTTTCTTCTCAACAAT	0.418000													11	494					0	0	0.016723	0	0	
TTN	7273	broad.mit.edu	37	2	179490044	179490044	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:179490044A>C	uc010zfg.1	-	190	37024	c.36800T>G	c.(36799-36801)CTA>CGA	p.L12267R	TTN_uc010zfh.1_Missense_Mutation_p.L5962R|TTN_uc010zfi.1_Missense_Mutation_p.L5895R|TTN_uc010zfj.1_Missense_Mutation_p.L5770R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	13194							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTGCTGTTAGTTGGACTTC	0.378000													51	489					0	0	0.014410	0	0	
TTN	7273	broad.mit.edu	37	2	179592845	179592845	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:179592845G>T	uc010zfg.1	-	64	16198	c.15974C>A	c.(15973-15975)ACT>AAT	p.T5325N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.T1986N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6252							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTTCACAGTTAAGATGCC	0.368000													13	51					1.52009e-12	1.60441e-12	0.024245	1	0	
TTN	7273	broad.mit.edu	37	2	179598199	179598199	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:179598199G>A	uc010zfg.1	-	51	12313	c.12089C>T	c.(12088-12090)GCA>GTA	p.A4030V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.A691V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4957							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGATCTCCTGCTGTCACCTG	0.473000													24	238					0	0	0.007291	0	0	
TTN	7273	broad.mit.edu	37	2	179600525	179600525	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:179600525A>G	uc010zfg.1	-	47	11140	c.10916T>C	c.(10915-10917)ATC>ACC	p.I3639T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I300T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4566							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCAATGATGATCAACTCTGC	0.398000													4	125					0	0	0.014758	0	0	
TTN	7273	broad.mit.edu	37	2	179642153	179642153	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:179642153C>T	uc010zfg.1	-	26	4863	c.4639G>A	c.(4639-4641)GTG>ATG	p.V1547M	TTN_uc010zfh.1_Missense_Mutation_p.V1501M|TTN_uc010zfi.1_Missense_Mutation_p.V1501M|TTN_uc010zfj.1_Missense_Mutation_p.V1501M|TTN_uc002unb.2_Missense_Mutation_p.V1547M|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1547							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACCTTCCACAGTTAAAATC	0.378000													7	77					0	0	0.001984	0	0	
ANKAR	150709	broad.mit.edu	37	2	190541514	190541514	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:190541514G>A	uc002uqw.1	+	1	85	c.85G>A	c.(85-87)GTC>ATC	p.V29I	ANKAR_uc002uqu.2_Intron|ANKAR_uc002uqv.1_Missense_Mutation_p.V100I	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	100						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			CTATAGAGAGGTCCATCAAAT	0.413000													9	312					0	0	0.004482	0	0	
DNAH7	56171	broad.mit.edu	37	2	196682507	196682507	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:196682507T>G	uc002utj.3	-	50	9439	c.9338A>C	c.(9337-9339)CAG>CCG	p.Q3113P		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3113	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TCCCAGAAGCTGATCTTGCAT	0.333000													11	110					0	0	0.010729	0	0	
DNAH7	56171	broad.mit.edu	37	2	196729698	196729698	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:196729698G>T	uc002utj.3	-	41	6782	c.6681C>A	c.(6679-6681)AGC>AGA	p.S2227R		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2227					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGATGAGCCAGCTTCTGTCTG	0.348000													39	199					9.39024e-22	1.00163e-21	0.009718	1	0	
HECW2	57520	broad.mit.edu	37	2	197183343	197183343	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:197183343T>G	uc002utm.1	-	9	2454	c.2271A>C	c.(2269-2271)GAA>GAC	p.E757D	HECW2_uc002utl.1_Missense_Mutation_p.E401D	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	757	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CAGCACTGCCTTCTTCTTGCG	0.662000													22	92					0	0	0.016522	0	0	
SGOL2	151246	broad.mit.edu	37	2	201434462	201434462	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:201434462A>C	uc002uvw.2	+	6	663	c.550A>C	c.(550-552)ACA>CCA	p.T184P	SGOL2_uc002uvv.3_Missense_Mutation_p.T184P|SGOL2_uc010zhd.1_Missense_Mutation_p.T184P|SGOL2_uc010zhe.1_Missense_Mutation_p.T184P	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	184					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						TAAATCAAAGACATTACCTGA	0.323000													25	162					0	0	0.016522	0	0	
SGOL2	151246	broad.mit.edu	37	2	201437583	201437583	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:201437583A>C	uc002uvw.2	+	7	2627	c.2514A>C	c.(2512-2514)AAA>AAC	p.K838N	SGOL2_uc010zhd.1_Missense_Mutation_p.K838N|SGOL2_uc010zhe.1_Missense_Mutation_p.K838N	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	838					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						ACCTAGAAAAAGATAACTTCT	0.313000													30	245					0	0	0.008361	0	0	
ALS2	57679	broad.mit.edu	37	2	202590090	202590090	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:202590090T>G	uc002uyo.2	-	20	3692	c.3336A>C	c.(3334-3336)CAA>CAC	p.Q1112H	ALS2_uc002uyp.3_Missense_Mutation_p.Q1112H|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	1112	MORN 3.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TGTAGACTCCTTGACCGCACA	0.388000													13	643					0	0	0.020292	0	0	
MAP2	4133	broad.mit.edu	37	2	210558070	210558070	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:210558070A>G	uc002vde.1	+	7	1424	c.1176A>G	c.(1174-1176)AAA>AAG	p.K392K	MAP2_uc002vdc.1_Silent_p.K392K|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.K388K	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	392					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CCTTACCCAAAGATGCTCACA	0.433000													3	141					0	0	0.009096	0	0	
MAP2	4133	broad.mit.edu	37	2	210574811	210574811	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:210574811A>G	uc002vde.1	+	12	5154	c.4906A>G	c.(4906-4908)ATC>GTC	p.I1636V	MAP2_uc002vdd.1_Missense_Mutation_p.I337V|MAP2_uc002vdf.1_Missense_Mutation_p.I280V|MAP2_uc002vdg.1_Missense_Mutation_p.I280V|MAP2_uc002vdh.1_Missense_Mutation_p.I337V|MAP2_uc002vdi.1_Missense_Mutation_p.I1632V	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1636					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CAAGTCTGCCATCTTGGTGCC	0.557000													6	179					0	0	0.001984	0	0	
C2orf67	151050	broad.mit.edu	37	2	211019060	211019060	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:211019060T>G	uc002vds.2	-	2	455	c.247A>C	c.(247-249)ATG>CTG	p.M83L	C2orf67_uc002vdt.2_Missense_Mutation_p.M83L|C2orf67_uc002vdw.2_Missense_Mutation_p.M83L|C2orf67_uc002vdy.1_Missense_Mutation_p.M83L|C2orf67_uc002vdv.2_Missense_Mutation_p.M83L|C2orf67_uc002vdx.1_Missense_Mutation_p.M83L	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	83										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		TTAGATCTCATTAAAAAAACA	0.313000													20	189					0	0	0.008871	0	0	
CPS1	1373	broad.mit.edu	37	2	211540529	211540529	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:211540529A>G	uc002vee.3	+	36	4371	c.4239A>G	c.(4237-4239)CAA>CAG	p.Q1413Q	CPS1_uc010fur.2_Silent_p.Q1419Q|CPS1_uc010fus.2_Silent_p.Q962Q	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1413					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GGCCGTCTCAAGAAGGACAGA	0.438000													8	50					0	0	0.004482	0	0	
ERBB4	2066	broad.mit.edu	37	2	212566700	212566700	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:212566700T>C	uc002veg.1	-	12	1579	c.1481A>G	c.(1480-1482)GAA>GGA	p.E494G	ERBB4_uc002veh.1_Missense_Mutation_p.E494G|ERBB4_uc010zji.1_Missense_Mutation_p.E494G|ERBB4_uc010zjj.1_Missense_Mutation_p.E494G|ERBB4_uc010fut.1_Missense_Mutation_p.E494G	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	494	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ACTACAATTTTCAGCTTTTCT	0.343000										TSP Lung(8;0.080)			33	242					0	0	0.012213	0	0	
ABCA12	26154	broad.mit.edu	37	2	215840618	215840618	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:215840618C>T	uc002vew.2	-	34	5492	c.5272G>A	c.(5272-5274)GTT>ATT	p.V1758I	ABCA12_uc002vev.2_Missense_Mutation_p.V1440I|ABCA12_uc010zjn.1_Missense_Mutation_p.V685I	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	1758	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GCAGTGGTAACAAAGACGATG	0.498000													17	189					0	0	0.004990	0	0	
XRCC5	7520	broad.mit.edu	37	2	217001884	217001884	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:217001884C>T	uc002vfy.2	+	11	1327	c.1187C>T	c.(1186-1188)GCT>GTT	p.A396V	XRCC5_uc002vfz.2_Missense_Mutation_p.A282V	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	396	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		GTTCGATATGCTTATGACAAA	0.398000								Direct_reversal_of_damage|NHEJ					27	237					0	0	0.024334	0	0	
USP37	57695	broad.mit.edu	37	2	219341575	219341575	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:219341575T>C	uc002vie.2	-	19	2484	c.2031A>G	c.(2029-2031)GAA>GAG	p.E677E	USP37_uc010fvs.1_Silent_p.E677E|USP37_uc010zkf.1_Silent_p.E677E|USP37_uc002vif.2_Silent_p.E677E|USP37_uc002vig.2_Silent_p.E583E	NM_020935	NP_065986	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	677					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(3)|ovary(1)|prostate(1)	5		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		TTTCCAGGTCTTCCTGCTGCT	0.383000													21	136					0	0	0.014323	0	0	
ZFAND2B	130617	broad.mit.edu	37	2	220072471	220072471	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:220072471T>C	uc002vka.2	+	3	424	c.252T>C	c.(250-252)TGT>TGC	p.C84C	ZFAND2B_uc010zkt.1_Silent_p.C84C|ZFAND2B_uc010fwd.1_Silent_p.C84C|ZFAND2B_uc002vjy.1_Silent_p.C84C|ZFAND2B_uc002vjz.1_Silent_p.C84C|ZFAND2B_uc002vkb.1_5'UTR	NM_138802	NP_620157	Q8WV99	ZFN2B_HUMAN	zinc finger, AN1-type domain 2B	84						endoplasmic reticulum	protein binding|zinc ion binding				0		Renal(207;0.0915)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACAGAGACTGTCGCTCTGATC	0.547000													4	141					0	0	0.009096	0	0	
WDR69	164781	broad.mit.edu	37	2	228769686	228769686	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:228769686A>C	uc002vpn.1	+	8	769	c.690A>C	c.(688-690)TCA>TCC	p.S230S	WDR69_uc010zlw.1_Silent_p.S215S|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	230	WD 4.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		TTAACACCTCAGGAGACAGAA	0.408000													27	265					0	0	0.007291	0	0	
SPHKAP	80309	broad.mit.edu	37	2	228890176	228890176	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:228890176T>G	uc002vpq.2	-	5	422	c.375A>C	c.(373-375)GAA>GAC	p.E125D	SPHKAP_uc002vpp.2_Missense_Mutation_p.E125D|SPHKAP_uc010zlx.1_Missense_Mutation_p.E125D	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	125						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAATTTCATTTTCTTTTGGTT	0.363000													4	237					0	0	0.009096	0	0	
SLC16A14	151473	broad.mit.edu	37	2	230902235	230902235	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:230902235T>G	uc002vqd.1	-	5	1757	c.1394A>C	c.(1393-1395)GAC>GCC	p.D465A	FBXO36_uc010fxi.1_Intron	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	465	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TTGCGTGATGTCATAGATCCA	0.338000													8	130					0	0	0.003080	0	0	
CAB39	51719	broad.mit.edu	37	2	231678800	231678800	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:231678800A>C	uc002vqx.2	+	7	1096	c.664A>C	c.(664-666)AAT>CAT	p.N222H	CAB39_uc010fxr.2_Missense_Mutation_p.N222H|CAB39_uc010fxq.2_Missense_Mutation_p.N222H|CAB39_uc002vqy.2_5'UTR	NM_016289	NP_057373	Q9Y376	CAB39_HUMAN	calcium binding protein 39	222					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	kinase binding			central_nervous_system(1)	1		all_lung(227;4.63e-07)|all_hematologic(139;1.83e-06)|Lung NSC(271;2.11e-05)|Acute lymphoblastic leukemia(138;5.51e-05)|Hepatocellular(293;0.0207)|Lung SC(224;0.187)		all cancers(144;1.64e-12)|Epithelial(121;5.29e-11)|LUSC - Lung squamous cell carcinoma(224;0.0154)|Lung(119;0.0177)|COAD - Colon adenocarcinoma(134;0.226)		TCATTCAGAAAATTATGTGAC	0.204000													4	160					0	0	0.009096	0	0	
COL6A3	1293	broad.mit.edu	37	2	238289663	238289663	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:238289663C>T	uc002vwl.2	-	5	2077	c.1792G>A	c.(1792-1794)GAC>AAC	p.D598N	COL6A3_uc002vwo.2_Missense_Mutation_p.D392N|COL6A3_uc010znj.1_Missense_Mutation_p.D191N|COL6A3_uc002vwq.2_Missense_Mutation_p.D392N|COL6A3_uc002vwr.2_Missense_Mutation_p.D191N|COL6A3_uc010znk.1_Missense_Mutation_p.D598N	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	598	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGGGAGGAGTCGAAAGCGATC	0.592000													16	110					0	0	0.024245	0	0	
PPP1R7	5510	broad.mit.edu	37	2	242105831	242105831	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr2:242105831A>C	uc002wat.1	+	8	809	c.794A>C	c.(793-795)GAG>GCG	p.E265A	PPP1R7_uc010fzm.1_Missense_Mutation_p.E249A|PPP1R7_uc002war.2_Missense_Mutation_p.E259A|PPP1R7_uc002was.2_Missense_Mutation_p.E265A|PPP1R7_uc002wau.1_Missense_Mutation_p.E222A|PPP1R7_uc002wav.1_Missense_Mutation_p.E191A	NM_002712	NP_002703	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	265	LRR 9.					cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			ovary(3)	3		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)		AATGGCATCGAGGTCATCGAG	0.617000													5	45					0	0	0.001984	0	0	
DEFB129	140881	broad.mit.edu	37	20	210029	210029	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:210029C>A	uc002wda.2	+	2	174	c.169C>A	c.(169-171)CCA>ACA	p.P57T		NM_080831	NP_543021	Q9H1M3	DB129_HUMAN	beta defensin 129 precursor	57					defense response to bacterium	extracellular region				ovary(1)	1		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			TTGTGTTGGACCAAAAGTGGT	0.378000													6	135					0.00198382	0.00202114	0.001984	1	0	
TGM3	7053	broad.mit.edu	37	20	2315813	2315813	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:2315813A>G	uc002wfx.3	+	11	1791	c.1694A>G	c.(1693-1695)AAG>AGG	p.K565R		NM_003245	NP_003236	Q08188	TGM3_HUMAN	transglutaminase 3 precursor	565					cell envelope organization|hair follicle morphogenesis|keratinization|peptide cross-linking|protein tetramerization	cytoplasm|extrinsic to internal side of plasma membrane	acyltransferase activity|calcium ion binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding|protein-glutamine gamma-glutamyltransferase activity	p.K565K(1)		large_intestine(4)|ovary(3)|breast(1)|skin(1)	9					L-Glutamine(DB00130)	AAGTACCTGAAGTCAGACAAC	0.557000													18	164					0	0	0.006122	0	0	
GPCPD1	56261	broad.mit.edu	37	20	5559187	5559187	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:5559187T>G	uc002wme.3	-	8	757	c.544A>C	c.(544-546)ATG>CTG	p.M182L	GPCPD1_uc002wmd.3_Missense_Mutation_p.M1L	NM_019593	NP_062539	Q9NPB8	GPCP1_HUMAN	hypothetical protein LOC56261	182					glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity				0						CTATTGGACATTTTGTGGAGT	0.453000													5	124					0	0	0.014758	0	0	
PLCB1	23236	broad.mit.edu	37	20	8630095	8630095	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:8630095G>T	uc002wnb.2	+	7	596	c.593G>T	c.(592-594)AGG>ATG	p.R198M	PLCB1_uc010zrb.1_Missense_Mutation_p.R97M|PLCB1_uc010gbv.1_Missense_Mutation_p.R198M|PLCB1_uc002wmz.1_Missense_Mutation_p.R198M|PLCB1_uc002wna.2_Missense_Mutation_p.R198M|PLCB1_uc002wnc.1_Missense_Mutation_p.R97M	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	198					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCATCTTCAAGGGTGAGCATG	0.254000													4	170					0.00909568	0.00925341	0.009096	1	0	
ANKRD5	63926	broad.mit.edu	37	20	10035216	10035216	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:10035216A>G	uc002wno.2	+	10	2534	c.2141A>G	c.(2140-2142)AAG>AGG	p.K714R	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.K714R|ANKRD5_uc010gbz.2_Missense_Mutation_p.K525R	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	714							calcium ion binding			ovary(1)|breast(1)	2						GGTTATACTAAGAAAGTGGAT	0.363000													6	150					0	0	0.021553	0	0	
C20orf26	26074	broad.mit.edu	37	20	20056254	20056254	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:20056254A>G	uc002wru.2	+	6	637	c.561A>G	c.(559-561)AAA>AAG	p.K187K	C20orf26_uc010gcw.1_Silent_p.K141K|C20orf26_uc010zse.1_Silent_p.K187K|C20orf26_uc010zsf.1_Silent_p.K187K	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	187										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		ACGTTCGCAAAGCCAGGTACA	0.483000													34	119					0	0	0.014410	0	0	
NKX2-2	4821	broad.mit.edu	37	20	21494272	21494272	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:21494272G>A	uc002wsi.2	-	1	393	c.36C>T	c.(34-36)GTC>GTT	p.V12V		NM_002509	NP_002500	O95096	NKX22_HUMAN	NK2 transcription factor related, locus 2	12					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			pancreas(1)|skin(1)	2						AGATGTCCTTGACCGAAAACC	0.572000													23	123					0	0	0.024334	0	0	
TMEM90B	79953	broad.mit.edu	37	20	24523780	24523780	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:24523780T>C	uc002wtw.1	+	2	680	c.47T>C	c.(46-48)ATC>ACC	p.I16T		NM_024893	NP_079169	Q9H7V2	SYNG1_HUMAN	transmembrane protein 90B	16	Cytoplasmic (Potential).				response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane					0						CACAGTAAAATCAGTGATGCT	0.517000													20	141					0	0	0.007413	0	0	
HCK	3055	broad.mit.edu	37	20	30674564	30674564	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:30674564G>A	uc002wxh.2	+	9	1140	c.969G>A	c.(967-969)GTG>GTA	p.V323V	HCK_uc010gdy.2_Silent_p.V302V|HCK_uc002wxi.2_Silent_p.V301V	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	323	Protein kinase.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTCATGCGGTGGTCACCAAGG	0.572000													21	75					0	0	0.014323	0	0	
RALY	22913	broad.mit.edu	37	20	32660008	32660008	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:32660008C>T	uc002xab.2	+	3	426	c.128C>T	c.(127-129)TCT>TTT	p.S43F	RALY_uc010zui.1_Missense_Mutation_p.S43F|RALY_uc002xac.2_Missense_Mutation_p.S43F|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.S43F	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	43	RRM.					catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1						ACCATCTTCTCTAAGTATGGC	0.512000													29	145					0	0	0.013726	0	0	
C20orf152	140894	broad.mit.edu	37	20	34571996	34571996	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:34571996A>C	uc002xes.1	+	5	656	c.500A>C	c.(499-501)GAG>GCG	p.E167A	C20orf152_uc002xer.1_Missense_Mutation_p.E167A|C20orf152_uc010gfp.1_Intron			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	167	cNMP.										0	Breast(12;0.00631)					ACCAAGGACGAGGATGGCAGC	0.542000													28	137					0	0	0.027356	0	0	
EMILIN3	90187	broad.mit.edu	37	20	39990482	39990482	+	Missense_Mutation	SNP	G	A	A	rs148759441		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:39990482G>A	uc002xjy.1	-	4	1951	c.1727C>T	c.(1726-1728)ACG>ATG	p.T576M		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	576						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				TGAGCTGCCCGTCCCTTCTGC	0.612000													17	218					0	0	0.006122	0	0	
ADNP	23394	broad.mit.edu	37	20	49509420	49509420	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:49509420C>T	uc002xvt.1	-	5	2176	c.1831G>A	c.(1831-1833)GCT>ACT	p.A611T	ADNP_uc002xvu.1_Missense_Mutation_p.A611T	NM_015339	NP_056154	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector	611						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						GGCACTGCAGCTTGAGGTGAA	0.433000													15	575					0	0	0.024245	0	0	
BCAS1	8537	broad.mit.edu	37	20	52601953	52601953	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:52601953T>C	uc002xws.2	-	7	1351	c.1013A>G	c.(1012-1014)AAG>AGG	p.K338R	BCAS1_uc010zza.1_Missense_Mutation_p.K96R|BCAS1_uc010zzb.1_Missense_Mutation_p.K286R|BCAS1_uc010gim.2_Missense_Mutation_p.K286R|BCAS1_uc002xwt.2_Missense_Mutation_p.K338R|BCAS1_uc010gil.1_Missense_Mutation_p.K338R	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	338						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			TTTGGAATTCTTGCCAGCCCC	0.517000													5	450					0	0	0.014758	0	0	
MC3R	4159	broad.mit.edu	37	20	54824097	54824097	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:54824097C>T	uc002xxb.2	+	1	310	c.198C>T	c.(196-198)AAC>AAT	p.N66N		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	103	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding	p.N103N(1)		ovary(2)|breast(2)	4			Colorectal(105;0.202)			TGGTCAGGAACGGCAACCTGC	0.562000													13	112					0	0	0.016723	0	0	
CASS4	57091	broad.mit.edu	37	20	55012519	55012519	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:55012519T>G	uc002xxp.2	+	3	561	c.336T>G	c.(334-336)GTT>GTG	p.V112V	CASS4_uc002xxq.3_Silent_p.V112V|CASS4_uc002xxr.2_Silent_p.V112V|CASS4_uc010zze.1_Intron|CASS4_uc010gio.2_Silent_p.V112V	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	112					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						CAGGCCCCGTTTATGAGCAGA	0.617000													6	196					0	0	0.021553	0	0	
CDH26	60437	broad.mit.edu	37	20	58559774	58559774	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:58559774T>C	uc002ybe.2	+	6	922	c.622T>C	c.(622-624)TCT>CCT	p.S208P	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	208	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			CTTCCTCATTTCTCAAACACC	0.373000													33	257					0	0	0.010818	0	0	
CDH26	60437	broad.mit.edu	37	20	58559811	58559811	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:58559811T>G	uc002ybe.2	+	6	959	c.659T>G	c.(658-660)GTT>GGT	p.V220G	CDH26_uc010zzy.1_RNA	NM_177980	NP_817089	Q8IXH8	CAD26_HUMAN	cadherin-like 26 isoform a	220	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|central_nervous_system(1)	4	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GGTTTCCGGGTTGATCGCCTT	0.378000													37	261					0	0	0.023175	0	0	
TAF4	6874	broad.mit.edu	37	20	60587991	60587991	+	Splice_Site	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:60587991C>T	uc002ybs.2	-	3	1522	c.1522_splice	c.e3-1	p.A508_splice		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4						interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TTCCAGGTGCCTGAAAAATAA	0.478000													40	120					0	0	0.007835	0	0	
TCFL5	10732	broad.mit.edu	37	20	61485451	61485451	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:61485451C>T	uc002ydp.2	-	5	1390	c.1297G>A	c.(1297-1299)GAG>AAG	p.E433K	TCFL5_uc002ydo.2_Missense_Mutation_p.E206K|TCFL5_uc002ydq.2_Missense_Mutation_p.E432K	NM_006602	NP_006593	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 protein	433	Helix-loop-helix motif.				cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)	1	Breast(26;5.68e-08)					TTGTCAGTCTCGGCATTGCAG	0.488000													14	141					0	0	0.016723	0	0	
DIDO1	11083	broad.mit.edu	37	20	61513128	61513128	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:61513128C>T	uc002ydr.1	-	16	4444	c.4180G>A	c.(4180-4182)GAG>AAG	p.E1394K	DIDO1_uc002yds.1_Missense_Mutation_p.E1394K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1394					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					AAGGCCCTCTCCGGGTCGTAC	0.602000													23	160					0	0	0.012319	0	0	
YTHDF1	54915	broad.mit.edu	37	20	61834292	61834292	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr20:61834292T>C	uc002yeh.2	-	4	1294	c.1000A>G	c.(1000-1002)AGA>GGA	p.R334G	YTHDF1_uc011aaq.1_Missense_Mutation_p.R284G	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	334										ovary(2)	2						GCCGCGTTTCTGTTGCGTGGG	0.647000													4	86					0	0	0.009096	0	0	
GRIK1	2897	broad.mit.edu	37	21	31027143	31027143	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr21:31027143A>C	uc002yno.1	-	5	1231	c.767T>G	c.(766-768)TTT>TGT	p.F256C	GRIK1_uc002ynn.2_Missense_Mutation_p.F256C|GRIK1_uc011acs.1_Missense_Mutation_p.F256C|GRIK1_uc011act.1_Missense_Mutation_p.F200C|GRIK1_uc010glq.1_Missense_Mutation_p.F114C|GRIK1_uc002ynr.2_Missense_Mutation_p.F256C	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	256	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GGTTGTGAAAAAGTAGTGATA	0.408000													33	319					0	0	0.013726	0	0	
ERG	2078	broad.mit.edu	37	21	39795341	39795341	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr21:39795341C>T	uc010gnw.2	-	5	695	c.400G>A	c.(400-402)GTG>ATG	p.V134M	ERG_uc002yxa.2_Missense_Mutation_p.V127M|ERG_uc011aek.1_Missense_Mutation_p.V35M|ERG_uc010gnv.2_Missense_Mutation_p.V35M|ERG_uc010gnx.2_Missense_Mutation_p.V134M|ERG_uc011ael.1_Missense_Mutation_p.V134M|ERG_uc002yxb.2_Missense_Mutation_p.V134M|ERG_uc011aem.1_Missense_Mutation_p.V127M|ERG_uc002yxc.3_Missense_Mutation_p.V134M	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	134	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				CCTGCTGGCACGATAACTCTG	0.612000													6	53					0	0	0.021553	0	0	
BACE2	25825	broad.mit.edu	37	21	42647325	42647325	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr21:42647325T>G	uc002yyw.2	+	9	1794	c.1331T>G	c.(1330-1332)ATT>AGT	p.I444S	BACE2_uc002yyx.2_Missense_Mutation_p.I394S|BACE2_uc002yyy.2_Missense_Mutation_p.F388V|BACE2_uc010goo.2_RNA	NM_012105	NP_036237	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2 isoform A	444	Extracellular (Potential).				membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				GTGTCTGAAATTTCCGGGCCT	0.512000													24	132					0	0	0.006320	0	0	
COL6A2	1292	broad.mit.edu	37	21	47546039	47546039	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr21:47546039A>C	uc002zia.1	+	26	2392	c.2310A>C	c.(2308-2310)GAA>GAC	p.E770D	COL6A2_uc002zhy.1_Missense_Mutation_p.E770D|COL6A2_uc002zhz.1_Missense_Mutation_p.E770D|COL6A2_uc002zib.1_Missense_Mutation_p.E176D|COL6A2_uc002zic.1_5'Flank	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	770	VWFA 2.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ACGAGAGTGAAAACCTCTACT	0.597000													8	269					0	0	0.003080	0	0	
MYO18B	84700	broad.mit.edu	37	22	26423450	26423450	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr22:26423450C>T	uc003abz.1	+	43	7760	c.7510C>T	c.(7510-7512)CAC>TAC	p.H2504Y	MYO18B_uc003aca.1_Missense_Mutation_p.H2385Y|MYO18B_uc010guy.1_Missense_Mutation_p.H2386Y|MYO18B_uc010guz.1_Missense_Mutation_p.H2384Y|MYO18B_uc011aka.1_Missense_Mutation_p.H1658Y|MYO18B_uc011akb.1_Missense_Mutation_p.H2017Y|MYO18B_uc010gva.1_Missense_Mutation_p.H487Y|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2504						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGATCCCGCTCACCTGTCTGA	0.542000													4	49					0	0	0.014758	0	0	
TRIOBP	11078	broad.mit.edu	37	22	38120199	38120199	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr22:38120199C>T	uc003atr.2	+	7	1907	c.1636C>T	c.(1636-1638)CGA>TGA	p.R546*	TRIOBP_uc003atu.2_Nonsense_Mutation_p.R374*|TRIOBP_uc003atq.1_Nonsense_Mutation_p.R546*|TRIOBP_uc003ats.1_Nonsense_Mutation_p.R374*	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	546					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TAGAGCTGCACGAGACAACCC	0.587000													17	213					0	0	0.006122	0	0	
XRCC6	2547	broad.mit.edu	37	22	42054327	42054327	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr22:42054327T>G	uc003bao.1	+	11	1563	c.1493T>G	c.(1492-1494)ATG>AGG	p.M498R	XRCC6_uc003bap.1_Missense_Mutation_p.M457R|XRCC6_uc011apc.1_Missense_Mutation_p.M448R|XRCC6_uc003baq.1_Missense_Mutation_p.M498R|XRCC6_uc003bar.1_Missense_Mutation_p.M498R|XRCC6_uc003bas.1_Missense_Mutation_p.M448R	NM_001469	NP_001460	P12956	XRCC6_HUMAN	ATP-dependent DNA helicase II, 70 kDa subunit	498					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			skin(2)|ovary(1)|lung(1)|kidney(1)	5						TTGGATTTGATGGAGCCGGAA	0.468000								Direct_reversal_of_damage|NHEJ					27	80					0	0	0.024334	0	0	
LMF2	91289	broad.mit.edu	37	22	50941834	50941834	+	Missense_Mutation	SNP	G	A	A	rs144527949		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr22:50941834G>A	uc003blp.2	-	14	2141	c.2110C>T	c.(2110-2112)CGG>TGG	p.R704W	LMF2_uc010hba.2_Missense_Mutation_p.R526W|LMF2_uc003blo.2_Missense_Mutation_p.R679W	NM_033200	NP_149977	Q9BU23	LMF2_HUMAN	lipase maturation factor 2	704						endoplasmic reticulum membrane|integral to membrane				breast(1)	1		all_cancers(38;1.31e-09)|all_epithelial(38;1.81e-08)|all_lung(38;0.000817)|Breast(42;0.00387)|Lung NSC(38;0.0124)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TTCTTTCGCCGGGTGGTCCTC	0.672000													3	37					0	0	0.004672	0	0	
CHL1	10752	broad.mit.edu	37	3	447378	447378	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:447378T>A	uc003bou.2	+	27	3882	c.3611T>A	c.(3610-3612)TTT>TAT	p.F1204Y	CHL1_uc003bot.2_Missense_Mutation_p.F1220Y|CHL1_uc011asi.1_Missense_Mutation_p.F1167Y	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1204	Cytoplasmic (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		ACAGCAACTTTTCCCCTTCGG	0.428000													12	93					0	0	0.010729	0	0	
LMCD1	29995	broad.mit.edu	37	3	8543665	8543665	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:8543665A>T	uc003bqq.2	+	1	155	c.41A>T	c.(40-42)AAG>ATG	p.K14M	uc003bqp.2_5'Flank|LMCD1_uc011atd.1_Translation_Start_Site|LMCD1_uc011ate.1_Translation_Start_Site	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	14					positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		GGAGTTAAAAAGGTGAGTGGA	0.522000													7	62					0	0	0.003080	0	0	
SRGAP3	9901	broad.mit.edu	37	3	9055164	9055164	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:9055164A>C	uc003brf.1	-	17	2651	c.1975T>G	c.(1975-1977)TTC>GTC	p.F659V	SRGAP3_uc003brg.1_Missense_Mutation_p.F635V	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	659	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GTAGGCCCGAAGCAGATGGCC	0.527000			T	RAF1	pilocytic astrocytoma								17	59					0	0	0.006122	0	0	
SLC6A11	6538	broad.mit.edu	37	3	10861460	10861460	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:10861460C>T	uc003bvz.2	+	3	489	c.455C>T	c.(454-456)GCA>GTA	p.A152V	SLC6A11_uc003bvy.1_Missense_Mutation_p.A152V	NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	152	Extracellular (Potential).				neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		ATCATCCTGGCATGGGCCATT	0.493000													43	207					0	0	0.009718	0	0	
KCNH8	131096	broad.mit.edu	37	3	19492867	19492867	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:19492867T>G	uc003cbk.1	+	10	1991	c.1796T>G	c.(1795-1797)CTT>CGT	p.L599R	KCNH8_uc011awe.1_3'UTR|KCNH8_uc010hex.1_Missense_Mutation_p.L60R|KCNH8_uc011awf.1_3'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	599	cNMP.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						ATGGAAGTTCTTAAAGACAGC	0.448000													29	136					0	0	0.006320	0	0	
CMTM6	54918	broad.mit.edu	37	3	32525568	32525568	+	Missense_Mutation	SNP	A	C	C	rs112118640		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:32525568A>C	uc003cfa.1	-	4	602	c.436T>G	c.(436-438)TTT>GTT	p.F146V		NM_017801	NP_060271	Q9NX76	CKLF6_HUMAN	CKLF-like MARVEL transmembrane domain containing	146	MARVEL.|Helical; (Potential).				chemotaxis	extracellular space|integral to membrane	cytokine activity				0						AGGAACATAAAACTTGCTATA	0.378000													18	202					0	0	0.006122	0	0	
GOLGA4	2803	broad.mit.edu	37	3	37368800	37368800	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:37368800A>G	uc003cgv.2	+	14	5727	c.5423A>G	c.(5422-5424)TAT>TGT	p.Y1808C	GOLGA4_uc010hgr.1_Missense_Mutation_p.Y1369C|GOLGA4_uc003cgw.2_Missense_Mutation_p.Y1830C|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Missense_Mutation_p.Y1689C	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1808	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						AACAAGAAATATTCCTTGATA	0.383000													8	107					0	0	0.003080	0	0	
ITGA9	3680	broad.mit.edu	37	3	37574896	37574896	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:37574896G>T	uc003chd.2	+	14	1518	c.1465G>T	c.(1465-1467)GTG>TTG	p.V489L	ITGA9_uc003chc.2_Missense_Mutation_p.V489L	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	489	Extracellular (Potential).				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		ACAGCAGCCTGTGAACTGCCT	0.567000													11	24					0.00010058	0.000103069	0.013537	1	0	
SCN11A	11280	broad.mit.edu	37	3	38950547	38950547	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:38950547T>A	uc011ays.1	-	9	1439	c.1240A>T	c.(1240-1242)ATA>TTA	p.I414L		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	414					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTGGCCTCTATCTCTGCAGCT	0.493000													9	245					0	0	0.006214	0	0	
SLC25A38	54977	broad.mit.edu	37	3	39433052	39433052	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:39433052T>C	uc003cjo.2	+	4	798	c.397T>C	c.(397-399)TCT>CCT	p.S133P		NM_017875	NP_060345	Q96DW6	S2538_HUMAN	solute carrier family 25, member 38	133	Solcar 2.|Helical; Name=3; (Potential).				erythrocyte differentiation|heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		GGGGGTGGGCTCTCGCTCTGT	0.527000													5	223					0	0	0.021553	0	0	
ZNF621	285268	broad.mit.edu	37	3	40573631	40573631	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:40573631C>T	uc003ckm.2	+	5	586	c.370C>T	c.(370-372)CAC>TAC	p.H124Y	ZNF621_uc003ckn.2_Missense_Mutation_p.H124Y|ZNF621_uc003cko.2_Missense_Mutation_p.H89Y|ZNF621_uc011aze.1_Missense_Mutation_p.H116Y	NM_001098414	NP_001091884	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		CGTTTCTCAGCACTTTGATTT	0.403000													4	147					0	0	0.009096	0	0	
NME6	10201	broad.mit.edu	37	3	48336623	48336623	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:48336623T>C	uc003csp.3	-	5	387	c.336A>G	c.(334-336)CCA>CCG	p.P112P	NME6_uc003cso.2_Silent_p.P120P|NME6_uc011bbh.1_Missense_Mutation_p.Q99R|NME6_uc010hju.2_Silent_p.P14P|NME6_uc011bbi.1_Intron	NM_005793	NP_005784	O75414	NDK6_HUMAN	nucleoside diphosphate kinase type 6	112					anti-apoptosis|apoptosis|CTP biosynthetic process|GTP biosynthetic process|negative regulation of cell growth|negative regulation of mitosis|UTP biosynthetic process	mitochondrion	ATP binding|metal ion binding|nucleoside diphosphate kinase activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		GGATAGAATCTGGGGCCACAT	0.587000													13	63					0	0	0.016723	0	0	
PBRM1	55193	broad.mit.edu	37	3	52620667	52620667	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:52620667T>A	uc003des.2	-	20	3173	c.3161A>T	c.(3160-3162)GAG>GTG	p.E1054V	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.E1054V|PBRM1_uc003der.2_Missense_Mutation_p.E1022V|PBRM1_uc003det.2_Missense_Mutation_p.E1069V|PBRM1_uc003deu.2_Missense_Mutation_p.E1069V|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.E1054V|PBRM1_uc010hmk.1_Missense_Mutation_p.E1029V|PBRM1_uc003dey.2_Missense_Mutation_p.E1029V|PBRM1_uc003dez.1_Missense_Mutation_p.E1053V|PBRM1_uc003dfb.1_Missense_Mutation_p.E966V|PBRM1_uc003dfa.1_Missense_Mutation_p.E400V	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	1054	BAH 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AAAAACATCCTCATCTCGGAA	0.398000			Mis|N|F|S|D|O		clear cell renal carcinoma|breast								16	90					0	0	0.024245	0	0	
IL17RD	54756	broad.mit.edu	37	3	57131970	57131970	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:57131970A>C	uc003dil.2	-	12	1850	c.1761T>G	c.(1759-1761)GTT>GTG	p.V587V	IL17RD_uc003dik.2_Silent_p.V563V|IL17RD_uc010hna.2_Silent_p.V443V|IL17RD_uc011bex.1_Silent_p.V443V	NM_017563	NP_060033	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D precursor	587	Cytoplasmic (Potential).					Golgi membrane|integral to membrane|plasma membrane	receptor activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		CATCATTTAAAACCAAGCCCG	0.557000													8	37					0	0	0.004482	0	0	
EPHA3	2042	broad.mit.edu	37	3	89498524	89498524	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:89498524T>C	uc003dqy.2	+	14	2721	c.2496T>C	c.(2494-2496)GAT>GAC	p.D832D	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	832	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCAATCAGGATGTAAGTATTT	0.438000										TSP Lung(6;0.00050)			29	145					0	0	0.010818	0	0	
PROS1	5627	broad.mit.edu	37	3	93596037	93596037	+	Splice_Site	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:93596037T>A	uc003drb.3	-	14	1986	c.1645_splice	c.e14-1	p.D549_splice	PROS1_uc010hoo.2_Splice_Site_p.D418_splice|PROS1_uc003dqz.3_Splice_Site_p.D418_splice	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein						leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	CAGAATATCCTGAAGAGCAGA	0.338000													5	69					0	0	0.014758	0	0	
OR5H1	26341	broad.mit.edu	37	3	97852429	97852429	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:97852429A>T	uc011bgt.1	+	1	888	c.888A>T	c.(886-888)CAA>CAT	p.Q296H		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						GAAATAAGCAAGTCACAGTTT	0.323000													21	174					0	0	0.008871	0	0	
ZBTB11	27107	broad.mit.edu	37	3	101371354	101371354	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:101371354A>C	uc003dve.3	-	10	2860	c.2630T>G	c.(2629-2631)ATG>AGG	p.M877R		NM_014415	NP_055230	O95625	ZBT11_HUMAN	zinc finger protein ZNF-U69274	877	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						ATGGTTGTTCATGTGTCTCCT	0.398000													28	209					0	0	0.009535	0	0	
ALCAM	214	broad.mit.edu	37	3	105243281	105243281	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:105243281A>C	uc003dvx.2	+	3	863	c.323A>C	c.(322-324)GAA>GCA	p.E108A	ALCAM_uc003dvv.2_Missense_Mutation_p.E108A|ALCAM_uc003dvw.1_Missense_Mutation_p.E108A|ALCAM_uc003dvy.2_Missense_Mutation_p.E108A|ALCAM_uc011bhh.1_Missense_Mutation_p.E57A	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	108	Extracellular (Potential).|Ig-like V-type 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						ATCAGTGATGAAAAGAGATTT	0.413000													35	205					0	0	0.019004	0	0	
IFT57	55081	broad.mit.edu	37	3	107881466	107881466	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:107881466A>G	uc003dwx.3	-	11	1396	c.1148T>C	c.(1147-1149)CTG>CCG	p.L383P		NM_018010	NP_060480	Q9NWB7	IFT57_HUMAN	estrogen-related receptor beta like 1	383	pDED.				activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			ovary(1)|skin(1)|pancreas(1)	3			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			TTCTTGCTTCAGTTTTGTTAA	0.363000													17	120					0	0	0.004990	0	0	
MYH15	22989	broad.mit.edu	37	3	108118049	108118049	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:108118049A>T	uc003dxa.1	-	35	4919	c.4862T>A	c.(4861-4863)ATT>AAT	p.I1621N		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1621	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GGTAACCTCAATTCTGCTCTT	0.478000													22	206					0	0	0.014323	0	0	
GRAMD1C	54762	broad.mit.edu	37	3	113652477	113652477	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:113652477T>G	uc003eaq.3	+	12	1405	c.1329T>G	c.(1327-1329)TCT>TCG	p.S443S	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Silent_p.S276S|GRAMD1C_uc003eas.2_Silent_p.S238S|GRAMD1C_uc003eat.2_Silent_p.S102S	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	443						integral to membrane				ovary(2)|skin(1)	3						TCATCCGATCTTCAAAACAGA	0.299000													23	176					0	0	0.024334	0	0	
ZDHHC23	254887	broad.mit.edu	37	3	113672689	113672689	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:113672689T>G	uc003eau.2	+	3	603	c.304T>G	c.(304-306)TTC>GTC	p.F102V	ZDHHC23_uc003eav.2_Missense_Mutation_p.F96V	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	102	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						GCTGCCTGTCTTCCTTCATGT	0.512000													52	353					0	0	0.014410	0	0	
ZDHHC23	254887	broad.mit.edu	37	3	113675244	113675244	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:113675244T>G	uc003eau.2	+	4	1230	c.931T>G	c.(931-933)TTC>GTC	p.F311V	ZDHHC23_uc003eav.2_Missense_Mutation_p.F305V|ZDHHC23_uc003eaw.1_5'Flank	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23	311	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						CCTTTTGATCTTCTTGCTCAC	0.388000													5	370					0	0	0.021553	0	0	
ADPRH	141	broad.mit.edu	37	3	119306346	119306346	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:119306346A>G	uc003ecs.2	+	5	993	c.695A>G	c.(694-696)AAA>AGA	p.K232R	ADPRH_uc010hqv.2_Missense_Mutation_p.K232R|ADPRH_uc011bjb.1_Missense_Mutation_p.K125R|ADPRH_uc003ect.2_Missense_Mutation_p.K232R	NM_001125	NP_001116	P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	232					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			ovary(1)	1		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		AATTACCTAAAACTTAGAGGG	0.408000													3	145					0	0	0.004672	0	0	
PLA1A	51365	broad.mit.edu	37	3	119325745	119325745	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:119325745A>G	uc003ecu.2	+	2	237	c.198A>G	c.(196-198)CTA>CTG	p.L66L	PLA1A_uc003ecv.2_Silent_p.L66L|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Intron	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	66					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						GTGGGCAGCTAGTAGAAGGAA	0.483000													4	373					0	0	0.009096	0	0	
PARP9	83666	broad.mit.edu	37	3	122264287	122264287	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:122264287T>G	uc010hri.2	-	7	1626	c.1481A>C	c.(1480-1482)AAT>ACT	p.N494T	PARP9_uc003eff.3_Missense_Mutation_p.N459T|PARP9_uc011bjs.1_Missense_Mutation_p.N459T|PARP9_uc003efg.2_Missense_Mutation_p.N39T|PARP9_uc003efi.2_Missense_Mutation_p.N459T|PARP9_uc003efh.2_Missense_Mutation_p.N494T|PARP9_uc003efj.2_Missense_Mutation_p.N459T	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	494					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		ACCACTGTAATTGTTCAAACT	0.443000													22	132					0	0	0.014323	0	0	
DIRC2	84925	broad.mit.edu	37	3	122591434	122591434	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:122591434T>G	uc003efw.3	+	8	1450	c.1311T>G	c.(1309-1311)TTT>TTG	p.F437L	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Missense_Mutation_p.F275L	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	437					transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		TTCTCACATTTTATCATACAG	0.299000													14	124					0	0	0.016723	0	0	
PODXL2	50512	broad.mit.edu	37	3	127379476	127379476	+	Missense_Mutation	SNP	A	C	C	rs115568415	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:127379476A>C	uc003ejq.2	+	3	629	c.605A>C	c.(604-606)CAG>CCG	p.Q202P		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	202	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						GCCAAGCCTCAGGTCCGTGAC	0.418000													4	137					0	0	0.009096	0	0	
IFT122	55764	broad.mit.edu	37	3	129182431	129182431	+	Silent	SNP	C	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:129182431C>G	uc003emm.2	+	6	584	c.378C>G	c.(376-378)GTC>GTG	p.V126V	IFT122_uc003eml.2_Silent_p.V177V|IFT122_uc003emn.2_Silent_p.V126V|IFT122_uc003emo.2_Silent_p.V74V|IFT122_uc003emp.2_5'UTR|IFT122_uc010htc.2_Silent_p.V177V|IFT122_uc011bky.1_5'UTR|IFT122_uc003emq.2_Silent_p.V74V|IFT122_uc003emr.2_5'UTR|IFT122_uc011bla.1_5'UTR|IFT122_uc011bkx.1_Silent_p.V74V|IFT122_uc011bkz.1_RNA	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	126	WD 3.				camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						AGAAGTCTGTCTCCAAACACA	0.338000													4	139					0	0	0.009096	0	0	
STAG1	10274	broad.mit.edu	37	3	136162135	136162135	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:136162135C>T	uc003era.1	-	15	1832	c.1540G>A	c.(1540-1542)GAG>AAG	p.E514K	STAG1_uc003erb.1_Missense_Mutation_p.E514K|STAG1_uc003erc.1_Missense_Mutation_p.E288K|STAG1_uc010hua.1_Missense_Mutation_p.E377K	NM_005862	NP_005853	Q8WVM7	STAG1_HUMAN	stromal antigen 1	514					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(2)	2						ATACCTTCCTCTCCTTGAACA	0.358000													7	160					0	0	0.003080	0	0	
DZIP1L	199221	broad.mit.edu	37	3	137786411	137786411	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:137786411G>A	uc003erq.2	-	14	2327	c.1964C>T	c.(1963-1965)ACC>ATC	p.T655I		NM_173543	NP_775814	Q8IYY4	DZI1L_HUMAN	DAZ interacting protein 1-like	655						intracellular	zinc ion binding			ovary(1)|pancreas(1)	2						CTCCTCCGAGGTCTCTGTGTC	0.637000													17	107					0	0	0.004990	0	0	
CLSTN2	64084	broad.mit.edu	37	3	140275381	140275381	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:140275381C>T	uc003etn.2	+	11	1891	c.1701C>T	c.(1699-1701)ATC>ATT	p.I567I	CLSTN2_uc003etm.2_Silent_p.I567I	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	567	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CGCAGTCCATCCTGGTGATGG	0.517000										HNSCC(16;0.037)			37	326					0	0	0.008740	0	0	
IGSF10	285313	broad.mit.edu	37	3	151155183	151155183	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:151155183A>G	uc011bod.1	-	6	7166	c.7166T>C	c.(7165-7167)CTG>CCG	p.L2389P	IGSF10_uc011bob.1_Missense_Mutation_p.L416P|IGSF10_uc011boc.1_Missense_Mutation_p.L368P	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2389	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCTTGCTATCAGATACTGATA	0.388000													38	292					0	0	0.007835	0	0	
KCNAB1	7881	broad.mit.edu	37	3	156170727	156170727	+	Splice_Site	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:156170727T>C	uc003far.2	+	3	421	c.357_splice	c.e3+2	p.E119_splice	KCNAB1_uc011bon.1_Splice_Site_p.E119_splice|KCNAB1_uc003fas.2_Splice_Site_p.E108_splice|KCNAB1_uc003fat.2_Splice_Site_p.E101_splice|KCNAB1_uc010hvt.1_Splice_Site_p.E101_splice	NM_172160	NP_751892	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related							cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			ovary(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TCAGATGAGGTAAGTTACCTT	0.368000													19	285					0	0	0.008871	0	0	
SHOX2	6474	broad.mit.edu	37	3	157818055	157818055	+	Missense_Mutation	SNP	G	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:157818055G>C	uc003fbr.2	-	3	740	c.601C>G	c.(601-603)CAA>GAA	p.Q201E	SHOX2_uc003fbs.2_Missense_Mutation_p.Q225E|SHOX2_uc010hvw.2_Missense_Mutation_p.Q201E	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	201					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TTATGGAGTTGATTTTCTTGT	0.308000													26	148					0	0	0.012213	0	0	
PIK3CA	5290	broad.mit.edu	37	3	178921553	178921553	+	Missense_Mutation	SNP	T	A	A	rs121913284		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:178921553T>A	uc003fjk.2	+	5	1192	c.1035T>A	c.(1033-1035)AAT>AAA	p.N345K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	345					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.N345K(29)|p.N345I(2)|p.N345S(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCTACGTGAATGTAAATATTC	0.308000		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			32	188					0	0	0.010818	0	0	
USP13	8975	broad.mit.edu	37	3	179426569	179426569	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:179426569A>T	uc003fkh.2	+	6	710	c.629A>T	c.(628-630)AAG>ATG	p.K210M	USP13_uc003fkf.2_Missense_Mutation_p.K210M	NM_003940	NP_003931	Q92995	UBP13_HUMAN	ubiquitin thiolesterase 13	210	UBP-type.				ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(1)	1	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			AGTGGTTGGAAGTGTGCCAGA	0.493000													12	174					0	0	0.010729	0	0	
EIF2B5	8893	broad.mit.edu	37	3	183861999	183861999	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:183861999T>C	uc003fmp.2	+	14	2346	c.1982T>C	c.(1981-1983)ATT>ACT	p.I661T	EIF2B5_uc003fmq.2_Missense_Mutation_p.I382T|EIF2B5_uc003fmr.2_Missense_Mutation_p.I69T	NM_003907	NP_003898	Q13144	EI2BE_HUMAN	eukaryotic translation initiation factor 2B,	661	W2.				astrocyte development|myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|positive regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus|RNA metabolic process	cytosol|eukaryotic translation initiation factor 2B complex|nucleus	guanyl-nucleotide exchange factor activity|transferase activity|translation initiation factor activity|translation initiation factor binding			ovary(5)	5	all_cancers(143;7.59e-11)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GCTCTTGGTATTTCCATGGCC	0.478000													38	281					0	0	0.009718	0	0	
PSMD2	5708	broad.mit.edu	37	3	184023845	184023845	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:184023845A>C	uc003fnn.1	+	14	1739	c.1706A>C	c.(1705-1707)AAG>ACG	p.K569T	PSMD2_uc011brj.1_Missense_Mutation_p.K410T|PSMD2_uc011brk.1_Missense_Mutation_p.K439T	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	569	PC 5.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	CCTGTAGGGAAGGGTGAGGCC	0.532000											OREG0015947	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	142					0	0	0.008871	0	0	
VPS8	23355	broad.mit.edu	37	3	184700383	184700383	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:184700383G>A	uc003fpb.1	+	40	3615	c.3444G>A	c.(3442-3444)ATG>ATA	p.M1148I	VPS8_uc010hyd.1_Missense_Mutation_p.M1058I|VPS8_uc010hye.1_Missense_Mutation_p.M577I	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	1150							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			TGGAGGCAATGATGGCCCCTC	0.393000													22	96					0	0	0.016522	0	0	
MAP3K13	9175	broad.mit.edu	37	3	185191526	185191526	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr3:185191526C>T	uc010hyf.2	+	12	2673	c.2407C>T	c.(2407-2409)CGA>TGA	p.R803*	MAP3K13_uc011brt.1_Nonsense_Mutation_p.R596*|MAP3K13_uc011bru.1_Nonsense_Mutation_p.R659*|MAP3K13_uc003fpi.2_Nonsense_Mutation_p.R803*|MAP3K13_uc010hyg.2_Nonsense_Mutation_p.R493*	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	803					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AGCGCTACCTCGAAAAACAAG	0.507000													21	179					0	0	0.008871	0	0	
POLN	353497	broad.mit.edu	37	4	2077220	2077220	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:2077220A>G	uc003ger.2	-	22	2414	c.2414T>C	c.(2413-2415)CTG>CCG	p.L805P	POLN_uc010icg.1_Missense_Mutation_p.L253P	NM_181808	NP_861524	Q7Z5Q5	DPOLN_HUMAN	DNA-directed DNA polymerase nu	805					DNA repair|DNA replication	nucleus	DNA binding|DNA-directed DNA polymerase activity			kidney(2)|ovary(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(23;0.0955)			TTCAAACAGCAGCTCATCATG	0.622000								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					12	61					0	0	0.016723	0	0	
JAKMIP1	152789	broad.mit.edu	37	4	6082037	6082037	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:6082037T>C	uc003giu.3	-	7	1380	c.1104A>G	c.(1102-1104)AAA>AAG	p.K368K	JAKMIP1_uc010idb.1_Silent_p.K368K|JAKMIP1_uc010idc.1_Silent_p.K203K|JAKMIP1_uc010idd.1_Silent_p.K368K|JAKMIP1_uc011bwc.1_Silent_p.K203K|JAKMIP1_uc003giv.3_Silent_p.K368K|JAKMIP1_uc010ide.2_Silent_p.K368K	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	368	Mediates interaction with TYK2 and GABBR1.|Potential.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						ACAGCTTTTCTTTCTGCAGCC	0.582000													4	36					0	0	0.021553	0	0	
SLC10A4	201780	broad.mit.edu	37	4	48490855	48490855	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:48490855T>C	uc003gyc.2	+	3	1432	c.1213T>C	c.(1213-1215)TCT>CCT	p.S405P	ZAR1_uc003gyd.2_5'Flank	NM_152679	NP_689892	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	405	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)	1						TACAGATATTTCTTATAAAAA	0.358000													7	109					0	0	0.001984	0	0	
UGT2B7	7364	broad.mit.edu	37	4	69964267	69964267	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:69964267C>T	uc003heg.3	+	2	777	c.731C>T	c.(730-732)ACT>ATT	p.T244I	UGT2B7_uc010ihq.2_Missense_Mutation_p.T244I	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	244					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						GGAAGACCCACTACATTATCT	0.353000													24	190					0	0	0.018920	0	0	
UGT2B7	7364	broad.mit.edu	37	4	69973826	69973826	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:69973826C>T	uc003heg.3	+	5	1142	c.1096C>T	c.(1096-1098)CCA>TCA	p.P366S	UGT2B7_uc010ihq.2_Intron	NM_001074	NP_001065	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2B7 precursor	366					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|skin(1)	2						CCTAGGTCATCCAAAGACCAG	0.418000													26	204					0	0	0.006320	0	0	
ANKRD17	26057	broad.mit.edu	37	4	74019707	74019707	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:74019707C>T	uc003hgp.2	-	6	1241	c.1124G>A	c.(1123-1125)GGA>GAA	p.G375E	ANKRD17_uc003hgo.2_Missense_Mutation_p.G262E|ANKRD17_uc003hgq.2_Missense_Mutation_p.G375E|ANKRD17_uc003hgr.2_Missense_Mutation_p.G375E|ANKRD17_uc011cbd.1_Missense_Mutation_p.G4E	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	375	ANK 5.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCCAGCACTTCCAGCTTCCAT	0.443000													29	226					0	0	0.008361	0	0	
NAAA	27163	broad.mit.edu	37	4	76846936	76846936	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:76846936G>A	uc003hjb.2	-	5	682	c.618C>T	c.(616-618)ATC>ATT	p.I206I	NAAA_uc003hja.2_Silent_p.I206I|NAAA_uc003hjc.3_Silent_p.I206I|NAAA_uc003hjd.3_Intron|NAAA_uc011cbq.1_Silent_p.I105I	NM_014435	NP_055250	Q02083	NAAA_HUMAN	N-acylethanolamine acid amidase isoform 1	206					lipid metabolic process	lysosome	hydrolase activity			skin(1)	1						ACAGGGCAGCGATAGCATTCT	0.433000													7	97					0	0	0.001984	0	0	
NUP54	53371	broad.mit.edu	37	4	77053844	77053844	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:77053844G>A	uc003hjs.2	-	6	867	c.739C>T	c.(739-741)CGT>TGT	p.R247C	NUP54_uc010ije.2_5'UTR|NUP54_uc011cbs.1_Missense_Mutation_p.R67C|NUP54_uc011cbt.1_Missense_Mutation_p.R199C|NUP54_uc003hjt.2_Missense_Mutation_p.R67C	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	247	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						TTTGGCGAACGCTCAACAACA	0.373000													24	124					0	0	0.016522	0	0	
PRKG2	5593	broad.mit.edu	37	4	82064024	82064024	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:82064024A>C	uc003hmh.2	-	10	1345	c.1331T>G	c.(1330-1332)TTT>TGT	p.F444C	PRKG2_uc011ccf.1_Missense_Mutation_p.F24C|PRKG2_uc011ccg.1_Missense_Mutation_p.F24C|PRKG2_uc011cch.1_Intron	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	444					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						TGATGAGGAAAATCTGGCCAC	0.468000													6	236					0	0	0.021553	0	0	
SEC31A	22872	broad.mit.edu	37	4	83774845	83774845	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:83774845T>A	uc003hnf.2	-	18	2196	c.2032A>T	c.(2032-2034)AAT>TAT	p.N678Y	SEC31A_uc003hne.2_Missense_Mutation_p.N411Y|SEC31A_uc011ccl.1_Missense_Mutation_p.N639Y|SEC31A_uc003hnl.2_Missense_Mutation_p.N639Y|SEC31A_uc003hng.2_Missense_Mutation_p.N678Y|SEC31A_uc003hnh.2_Missense_Mutation_p.N678Y|SEC31A_uc003hni.2_Missense_Mutation_p.N678Y|SEC31A_uc003hnj.2_Missense_Mutation_p.N639Y|SEC31A_uc011ccm.1_Missense_Mutation_p.N673Y|SEC31A_uc011ccn.1_Missense_Mutation_p.N678Y|SEC31A_uc003hnk.2_Missense_Mutation_p.N639Y|SEC31A_uc003hnm.2_Missense_Mutation_p.N678Y|SEC31A_uc003hnn.1_Missense_Mutation_p.N678Y	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	678	WD 7.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TCTCCTTCATTTTCAAGCCTG	0.388000													23	128					0	0	0.018920	0	0	
PTPN13	5783	broad.mit.edu	37	4	87684297	87684297	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:87684297A>T	uc003hpz.2	+	24	4451	c.3971A>T	c.(3970-3972)GAT>GTT	p.D1324V	PTPN13_uc003hpy.2_Missense_Mutation_p.D1324V|PTPN13_uc003hqa.2_Missense_Mutation_p.D1305V|PTPN13_uc003hqb.2_Missense_Mutation_p.D1133V	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	1324						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TCAGACATGGATGAAGCCACT	0.373000													25	179					0	0	0.007291	0	0	
TACR3	6870	broad.mit.edu	37	4	104511116	104511116	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:104511116C>T	uc003hxe.1	-	5	1264	c.1121G>A	c.(1120-1122)TGT>TAT	p.C374Y		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	374	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GATGAAAGGACACCAGCGAAA	0.453000													19	118					0	0	0.007413	0	0	
PPA2	27068	broad.mit.edu	37	4	106320269	106320269	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:106320269A>C	uc003hxl.2	-	8	728	c.708T>G	c.(706-708)AAT>AAG	p.N236K	PPA2_uc003hxm.2_Missense_Mutation_p.N218K|PPA2_uc003hxn.2_Missense_Mutation_p.N207K|PPA2_uc003hxo.2_Missense_Mutation_p.N134K|PPA2_uc003hxp.2_Missense_Mutation_p.N70K|PPA2_uc003hxq.2_Missense_Mutation_p.N143K|PPA2_uc003hxr.2_Missense_Mutation_p.N143K	NM_176869	NP_789845	Q9H2U2	IPYR2_HUMAN	inorganic pyrophosphatase 2 isoform 1 precursor	236					diphosphate metabolic process|tRNA aminoacylation for protein translation	mitochondrial matrix	inorganic diphosphatase activity|magnesium ion binding			pancreas(1)	1		Myeloproliferative disorder(5;0.0255)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.03e-07)		ATCTAAACCAATTAAGAGTAG	0.294000													30	169					0	0	0.009535	0	0	
TBCK	93627	broad.mit.edu	37	4	107016730	107016730	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:107016730T>A	uc010ilv.2	-	25	2845	c.2480A>T	c.(2479-2481)GAG>GTG	p.E827V	TBCK_uc003hyb.2_Missense_Mutation_p.E570V|TBCK_uc003hye.2_Missense_Mutation_p.E788V|TBCK_uc003hyc.2_Missense_Mutation_p.E764V|TBCK_uc003hyd.2_Missense_Mutation_p.E655V|TBCK_uc003hyf.2_Missense_Mutation_p.E827V	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	827	Rhodanese.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CTGGGTAAGCTCCCCTTCTGC	0.453000													22	141					0	0	0.018920	0	0	
ANK2	287	broad.mit.edu	37	4	114279513	114279513	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:114279513T>C	uc003ibe.3	+	38	9839	c.9739T>C	c.(9739-9741)TCT>CCT	p.S3247P	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.S549P|ANK2_uc011cgb.1_Missense_Mutation_p.S3262P	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3214					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGCCCCGACTCTTCTGAACC	0.483000													39	187					0	0	0.007835	0	0	
ANK2	287	broad.mit.edu	37	4	114302620	114302620	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:114302620A>T	uc003ibe.3	+	46	11967	c.11867A>T	c.(11866-11868)AAT>ATT	p.N3956I	ANK2_uc003ibd.3_Missense_Mutation_p.N1862I|ANK2_uc003ibf.3_Missense_Mutation_p.N1871I|ANK2_uc011cgc.1_Missense_Mutation_p.N1047I|ANK2_uc003ibg.3_Missense_Mutation_p.N947I|ANK2_uc003ibh.3_Missense_Mutation_p.N576I|ANK2_uc011cgd.1_Missense_Mutation_p.N1258I|ANK2_uc010imr.2_Missense_Mutation_p.M130L|ANK2_uc010ims.2_Missense_Mutation_p.M69L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3923				NN -> SM (in Ref. 5; AC093879).	axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAGGACAACAATGAGTAAAGC	0.478000													11	87					0	0	0.008291	0	0	
MYOZ2	51778	broad.mit.edu	37	4	120107204	120107204	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:120107204C>T	uc003icp.3	+	6	857	c.644C>T	c.(643-645)ACA>ATA	p.T215I		NM_016599	NP_057683	Q9NPC6	MYOZ2_HUMAN	myozenin 2	215							protein phosphatase 2B binding				0						CTATTGCTAACAGATCCCAGG	0.383000													21	188					0	0	0.010504	0	0	
PDE5A	8654	broad.mit.edu	37	4	120423782	120423782	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:120423782A>C	uc003idh.2	-	19	2515	c.2360T>G	c.(2359-2361)TTT>TGT	p.F787C	uc003ide.3_Intron|PDE5A_uc003idf.2_Missense_Mutation_p.F745C|PDE5A_uc003idg.2_Missense_Mutation_p.F735C	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	787	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	TCCTTGATCAAAAAATTCAGT	0.313000													3	184					0	0	0.004672	0	0	
PDE5A	8654	broad.mit.edu	37	4	120488237	120488237	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:120488237T>G	uc003idh.2	-	4	1049	c.894A>C	c.(892-894)AAA>AAC	p.K298N	PDE5A_uc003idf.2_Missense_Mutation_p.K256N|PDE5A_uc003idg.2_Missense_Mutation_p.K246N	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	298	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	CCTTTTCATCTTTTTCAGTAA	0.378000													4	198					0	0	0.014758	0	0	
DCLK2	166614	broad.mit.edu	37	4	151168778	151168778	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:151168778T>C	uc003ilm.3	+	13	1902	c.1802T>C	c.(1801-1803)CTC>CCC	p.L601P	DCLK2_uc003iln.3_Missense_Mutation_p.L600P|DCLK2_uc003ilo.3_Missense_Mutation_p.L618P|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	601	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					CAGGAAGATCTCTTCGACCAG	0.488000													3	77					0	0	0.004672	0	0	
PET112L	5188	broad.mit.edu	37	4	152638205	152638205	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:152638205G>A	uc003iml.2	-	4	475	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	PET112L_uc003imm.3_Nonsense_Mutation_p.Q155*	NM_004564	NP_004555	O75879	GATB_HUMAN	PET112-like precursor	155						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding				0	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)			L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGGAGCCTCTGCTGGGTAATT	0.478000													12	163					0	0	0.014323	0	0	
TDO2	6999	broad.mit.edu	37	4	156841122	156841122	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:156841122A>G	uc003ipf.1	+	12	1265	c.1201A>G	c.(1201-1203)AGC>GGC	p.S401G		NM_005651	NP_005642	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	401					tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	CTCCTACTTCAGCAGTGATGA	0.353000													6	113					0	0	0.001984	0	0	
CCDC111	201973	broad.mit.edu	37	4	185593465	185593465	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr4:185593465A>C	uc003iwk.2	+	7	1128	c.695A>C	c.(694-696)AAA>ACA	p.K232T	CCDC111_uc010isd.1_RNA|CCDC111_uc003iwj.2_Missense_Mutation_p.K232T|CCDC111_uc003iwl.2_Missense_Mutation_p.K232T|CCDC111_uc003iwm.2_Missense_Mutation_p.K103T|CCDC111_uc003iwn.2_Missense_Mutation_p.K57T	NM_152683	NP_689896	Q96LW4	CC111_HUMAN	coiled-coil domain containing 111	232					DNA replication, synthesis of RNA primer		DNA primase activity			central_nervous_system(1)	1		all_lung(41;9.65e-12)|Lung NSC(41;1.64e-11)|Colorectal(36;0.00531)|Hepatocellular(41;0.00932)|Renal(120;0.0246)|Prostate(90;0.0283)|all_hematologic(60;0.0749)|all_neural(102;0.131)		all cancers(43;5.84e-27)|Epithelial(43;2.2e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.28e-11)|STAD - Stomach adenocarcinoma(60;2.66e-05)|GBM - Glioblastoma multiforme(59;3.03e-05)|Colorectal(24;7.57e-05)|BRCA - Breast invasive adenocarcinoma(30;0.000249)|COAD - Colon adenocarcinoma(29;0.000502)|LUSC - Lung squamous cell carcinoma(40;0.00995)|READ - Rectum adenocarcinoma(43;0.173)		TCTTTCAATAAAATGTTCACA	0.448000													22	123					0	0	0.010504	0	0	
IRX1	79192	broad.mit.edu	37	5	3599747	3599747	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:3599747G>A	uc003jde.2	+	2	737	c.685G>A	c.(685-687)GAC>AAC	p.D229N		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	229						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GGAAAGCATCGACATTGACAA	0.642000													6	66					0	0	0.021553	0	0	
FASTKD3	79072	broad.mit.edu	37	5	7868084	7868084	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:7868084T>C	uc003jeb.2	-	2	250	c.113A>G	c.(112-114)AAG>AGG	p.K38R	FASTKD3_uc011cmp.1_5'UTR|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	38					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						CAGACGCTCCTTGACTACCTT	0.403000													6	186					0	0	0.021553	0	0	
DNAH5	1767	broad.mit.edu	37	5	13769199	13769199	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:13769199T>G	uc003jfd.2	-	58	9809	c.9767A>C	c.(9766-9768)AAG>ACG	p.K3256T	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3256	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TACCTCAGCCTTGACCTTTTC	0.428000									Kartagener_syndrome				47	645					0	0	0.014410	0	0	
ANKH	56172	broad.mit.edu	37	5	14758683	14758683	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:14758683A>C	uc003jfm.3	-	3	669	c.338T>G	c.(337-339)ATT>AGT	p.I113S		NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	113	Extracellular (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						TTTATTGATAATGTAGTATCC	0.413000													5	159					0	0	0.021553	0	0	
PRDM9	56979	broad.mit.edu	37	5	23526783	23526783	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:23526783G>A	uc003jgo.2	+	11	1768	c.1586G>A	c.(1585-1587)TGT>TAT	p.C529Y		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	529	C2H2-type 2; degenerate.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TATGGAGAGTGTGGACAAGGT	0.468000										HNSCC(3;0.000094)			15	146					0	0	0.020292	0	0	
PDZD2	23037	broad.mit.edu	37	5	32077580	32077580	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:32077580A>C	uc003jhl.2	+	19	3938	c.3550A>C	c.(3550-3552)AAG>CAG	p.K1184Q	PDZD2_uc003jhm.2_Missense_Mutation_p.K1184Q|PDZD2_uc011cnx.1_Missense_Mutation_p.K1010Q	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1184					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						ATCTCTGGGAAAGCTGACCAC	0.498000													9	132					0	0	0.004482	0	0	
ADAMTS12	81792	broad.mit.edu	37	5	33616123	33616123	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:33616123T>C	uc003jia.1	-	15	2361	c.2198A>G	c.(2197-2199)GAA>GGA	p.E733G	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E648G	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	733	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCCCTCAATTTCCATCACTCT	0.438000										HNSCC(64;0.19)			80	148					0	0	0.014410	0	0	
ADAMTS12	81792	broad.mit.edu	37	5	33891900	33891900	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:33891900A>C	uc003jia.1	-	1	225	c.62T>G	c.(61-63)TTT>TGT	p.F21C	ADAMTS12_uc010iuq.1_Missense_Mutation_p.F21C|ADAMTS12_uc003jib.1_Missense_Mutation_p.F21C	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	21					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AAGCGCCCCAAAGTTAAGGAG	0.488000										HNSCC(64;0.19)			41	198					0	0	0.007835	0	0	
SPEF2	79925	broad.mit.edu	37	5	35654723	35654723	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:35654723A>G	uc003jjo.2	+	7	984	c.873A>G	c.(871-873)AAA>AAG	p.K291K	SPEF2_uc003jjn.1_Silent_p.K291K|SPEF2_uc003jjq.3_Silent_p.K291K	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	291					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGTACATTAAAAAAATCCAGA	0.398000													13	163					0	0	0.020292	0	0	
UGT3A1	133688	broad.mit.edu	37	5	35965721	35965721	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:35965721A>T	uc003jjv.1	-	4	767	c.610T>A	c.(610-612)TTT>ATT	p.F204I	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.F204I|UGT3A1_uc011cor.1_Missense_Mutation_p.F170I|UGT3A1_uc003jjy.1_Missense_Mutation_p.F150I	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	204	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AACATCAGAAAATTCTTCACT	0.473000													10	147					0	0	0.010729	0	0	
UGT3A2	167127	broad.mit.edu	37	5	36066860	36066860	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:36066860C>T	uc003jjz.1	-	1	125	c.32G>A	c.(31-33)GGC>GAC	p.G11D	UGT3A2_uc011cos.1_Missense_Mutation_p.G11D|UGT3A2_uc011cot.1_5'UTR	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	11						integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAGAAGGAAGCCCACTAGAAG	0.612000													23	160					0	0	0.018920	0	0	
C5orf42	65250	broad.mit.edu	37	5	37108536	37108536	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:37108536T>C	uc011cpa.1	-	51	9507	c.9276A>G	c.(9274-9276)AAA>AAG	p.K3092K	C5orf42_uc003jko.1_Silent_p.K123K|C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Silent_p.K1610K|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.K2185K	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	3092										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TTCCATGTTTTTTTGTATGCT	0.398000													12	244					0	0	0.010729	0	0	
C5orf34	375444	broad.mit.edu	37	5	43503793	43503793	+	Missense_Mutation	SNP	C	T	T	rs145557336	byFrequency	TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:43503793C>T	uc003jnz.1	-	6	1319	c.1002G>A	c.(1000-1002)ATG>ATA	p.M334I		NM_198566	NP_940968	Q96MH7	CE034_HUMAN	hypothetical protein LOC375444	334										breast(1)	1	Lung NSC(6;2.07e-05)					TGTACCAAACCATTTTCACTA	0.378000													61	362					0	0	0.014410	0	0	
SFRS12	140890	broad.mit.edu	37	5	65458386	65458386	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:65458386T>G	uc003juo.2	+	6	1033	c.373T>G	c.(373-375)TTT>GTT	p.F125V	SFRS12_uc003jun.2_Missense_Mutation_p.F241V|SFRS12_uc010iwy.2_Missense_Mutation_p.F125V	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	125	RRM.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		GGCCCTTGCTTTTAATGGAGT	0.373000													8	142					0	0	0.008291	0	0	
ANKRA2	57763	broad.mit.edu	37	5	72858699	72858699	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:72858699G>T	uc003kcu.1	-	2	654	c.8C>A	c.(7-9)ACA>AAA	p.T3K	UTP15_uc003kcw.1_5'Flank|UTP15_uc011cso.1_5'Flank|UTP15_uc011csp.1_5'Flank|ANKRA2_uc003kcv.2_Missense_Mutation_p.T3K	NM_023039	NP_075526	Q9H9E1	ANRA2_HUMAN	ankyrin repeat, family A (RFXANK-like), 2	3						cytoskeleton|cytosol|membrane	low-density lipoprotein particle binding				0		Lung NSC(167;0.0378)|Ovarian(174;0.0908)		OV - Ovarian serous cystadenocarcinoma(47;3.71e-54)		ATTTGTTGATGTATCCATGAT	0.393000													6	127					1.12685e-05	1.1632e-05	0.004482	1	0	
ENC1	8507	broad.mit.edu	37	5	73931059	73931059	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:73931059C>T	uc003kdc.3	-	2	2383	c.1252G>A	c.(1252-1254)GAC>AAC	p.D418N	ENC1_uc011css.1_Missense_Mutation_p.D345N	NM_003633	NP_003624	O14682	ENC1_HUMAN	ectodermal-neural cortex (with BTB-like domain)	418	Kelch 3.				nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			ovary(1)|pancreas(1)|skin(1)	3		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		ATTGTGGGGTCATAATGTTCT	0.552000													20	104					0	0	0.008871	0	0	
ARSK	153642	broad.mit.edu	37	5	94927138	94927138	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:94927138T>G	uc003kld.2	+	6	1063	c.905T>G	c.(904-906)CTT>CGT	p.L302R	ARSK_uc010jbg.2_Missense_Mutation_p.L143R|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	302						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		CAATTAGATCTTCTTCAGAAA	0.348000													8	220					0	0	0.003080	0	0	
PPIP5K2	23262	broad.mit.edu	37	5	102494226	102494226	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:102494226A>G	uc003kod.3	+	16	2205	c.1686A>G	c.(1684-1686)ATA>ATG	p.I562M	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Missense_Mutation_p.I562M	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	562					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						ACCTCAAAATATATGCCTCTG	0.333000													19	131					0	0	0.010504	0	0	
PCDHGC4	56098	broad.mit.edu	37	5	140865158	140865158	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:140865158T>G	uc003lky.1	+	1	418	c.418T>G	c.(418-420)TTG>GTG	p.L140V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Missense_Mutation_p.L140V	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	140	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCTGGACTTGGAAATTGG	0.542000													20	82					0	0	0.008871	0	0	
NR3C1	2908	broad.mit.edu	37	5	142661596	142661596	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:142661596T>G	uc003lmz.2	-	9	2684	c.2192A>C	c.(2191-2193)AAT>ACT	p.N731T	NR3C1_uc003lmy.2_Missense_Mutation_p.N732T|NR3C1_uc003lna.2_Intron|NR3C1_uc003lnb.2_Missense_Mutation_p.N731T|NR3C1_uc011dbk.1_Missense_Mutation_p.N334T|NR3C1_uc003lnc.2_Missense_Mutation_p.N731T|NR3C1_uc003lnd.2_Missense_Mutation_p.N731T|NR3C1_uc003lne.2_Missense_Mutation_p.N731T|NR3C1_uc003lnf.2_Missense_Mutation_p.N732T	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	731	Steroid-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	GTTAAGGAGATTTTCAACCAC	0.358000													7	110					0	0	0.003080	0	0	
WWC1	23286	broad.mit.edu	37	5	167841353	167841353	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr5:167841353G>A	uc003lzu.2	+	9	1035	c.942G>A	c.(940-942)AGG>AGA	p.R314R	WWC1_uc003lzv.2_Silent_p.R314R|WWC1_uc011den.1_Silent_p.R314R|WWC1_uc003lzw.2_Silent_p.R113R	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	314	Potential.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		TGGCCCCCAGGATCGCCAACC	0.547000													9	16					0	0	0.006214	0	0	
MAK	4117	broad.mit.edu	37	6	10804105	10804105	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:10804105A>G	uc003mzl.2	-	6	740	c.511T>C	c.(511-513)TTA>CTA	p.L171L	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Silent_p.L171L|MAK_uc010jov.1_RNA	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	171	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				GATCTCAGTAAAACTTCAGGG	0.418000													5	156					0	0	0.014758	0	0	
SLC17A1	6568	broad.mit.edu	37	6	25799054	25799054	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:25799054T>G	uc003nfh.3	-	12	1479	c.1363A>C	c.(1363-1365)ATT>CTT	p.I455L	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Missense_Mutation_p.I453L|SLC17A1_uc010jqc.1_Missense_Mutation_p.I399L	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	455					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						CAGTCCTGAATTTCTGCTGTA	0.433000													17	167					0	0	0.006122	0	0	
HIST1H2AC	8334	broad.mit.edu	37	6	26124540	26124540	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:26124540C>T	uc003ngm.2	+	1	168	c.80C>T	c.(79-81)CCG>CTG	p.P27L	HIST1H2BC_uc003ngk.3_5'Flank|HIST1H2BC_uc003ngl.2_5'Flank|HIST1H2AC_uc003ngn.2_RNA|HIST1H2AC_uc003ngo.2_RNA|HIST1H2AC_uc003ngp.2_Missense_Mutation_p.P27L	NM_003512	NP_003503	Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	27					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CTCCAGTTCCCGGTGGGCCGA	0.612000													3	52					0	0	0.004672	0	0	
BTN3A1	11119	broad.mit.edu	37	6	26410259	26410259	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:26410259T>C	uc003nhv.2	+	7	1331	c.963T>C	c.(961-963)TCT>TCC	p.S321S	BTN3A1_uc011dkj.1_Silent_p.S321S|BTN3A1_uc011dkk.1_Silent_p.S269S|BTN3A1_uc010jqj.2_Silent_p.S321S	NM_007048	NP_008979	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1 isoform a	321	Cytoplasmic (Potential).				lipid metabolic process	integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2						AGTATGCATCTCGTAAGTGCC	0.468000													32	238					0	0	0.017118	0	0	
MAS1L	116511	broad.mit.edu	37	6	29455004	29455004	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:29455004T>G	uc011dlq.1	-	1	676	c.676A>C	c.(676-678)AAG>CAG	p.K226Q		NM_052967	NP_443199	P35410	MAS1L_HUMAN	MAS1 oncogene-like	226	Helical; Name=5; (Potential).					cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			ovary(7)|lung(2)	9						CCAGAAAGCTTTAGAAATATG	0.443000													4	87					0	0	0.009096	0	0	
DHX16	8449	broad.mit.edu	37	6	30630751	30630751	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:30630751T>C	uc003nqz.2	-	8	1577	c.1365A>G	c.(1363-1365)AGA>AGG	p.R455R	DHX16_uc003nqy.2_5'Flank|DHX16_uc011dmo.1_Silent_p.R395R	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	455	Helicase ATP-binding.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						TGGCAGCCACTCTCCGGGGTT	0.527000													6	86					0	0	0.008291	0	0	
ITPR3	3710	broad.mit.edu	37	6	33632880	33632880	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:33632880A>G	uc011drk.1	+	13	1518	c.1299A>G	c.(1297-1299)TCA>TCG	p.S433S		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	433	Cytoplasmic (Potential).|MIR 5.				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CCATCGTGTCAGTGCCCGTGT	0.567000													19	92					0	0	0.014323	0	0	
FTSJD2	23070	broad.mit.edu	37	6	37430704	37430704	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:37430704C>T	uc003ons.2	+	13	1678	c.1425C>T	c.(1423-1425)TCC>TCT	p.S475S		NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	475					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						ACACGGATTCCGACGTCAACT	0.502000													22	194					0	0	0.010504	0	0	
DNAH8	1769	broad.mit.edu	37	6	38690577	38690577	+	Translation_Start_Site	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:38690577C>T	uc003ooe.1	+	1	26	c.-574C>T	c.(-576--572)CACGA>CATGA		DNAH8_uc003ood.1_Translation_Start_Site	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GCATTCCGCACGACGGGGGAT	0.483000													4	37					0	0	0.009096	0	0	
DNAH8	1769	broad.mit.edu	37	6	38950132	38950132	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:38950132A>C	uc003ooe.1	+	84	12794	c.12194A>C	c.(12193-12195)AAA>ACA	p.K4065T	DNAH8_uc003oog.1_Missense_Mutation_p.K514T	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GAGCGACGAAAATTTGGCCCC	0.343000													8	280					0	0	0.004482	0	0	
HSP90AB1	3326	broad.mit.edu	37	6	44220806	44220806	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:44220806T>C	uc003oxa.1	+	11	1840	c.1756T>C	c.(1756-1758)TCT>CCT	p.S586P	HSP90AB1_uc011dvr.1_Missense_Mutation_p.S576P|HSP90AB1_uc003oxb.1_Missense_Mutation_p.S586P|HSP90AB1_uc011dvs.1_Missense_Mutation_p.S406P|HSP90AB1_uc003oxc.1_Missense_Mutation_p.S224P	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	586					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TAGACTTGTGTCTTCACCTTG	0.473000													6	115					0	0	0.001984	0	0	
TCTE1	202500	broad.mit.edu	37	6	44254189	44254189	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:44254189C>T	uc003oxi.2	-	3	514	c.358G>A	c.(358-360)GTG>ATG	p.V120M	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	120										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TTGGCGGTCACAGCCAGTGGT	0.592000													20	151					0	0	0.006320	0	0	
TDRD6	221400	broad.mit.edu	37	6	46661814	46661814	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:46661814A>T	uc003oyj.2	+	1	5949	c.5949A>T	c.(5947-5949)AAA>AAT	p.K1983N	TDRD6_uc010jze.2_Missense_Mutation_p.K1977N	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1983					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			TAGAGTATAAAAACAGGGATG	0.393000													6	153					0	0	0.001984	0	0	
TDRD6	221400	broad.mit.edu	37	6	46663629	46663629	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:46663629A>C	uc003oyj.2	+	2	6118	c.6118A>C	c.(6118-6120)AGA>CGA	p.R2040R	TDRD6_uc010jze.2_Silent_p.R2034R	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	2040	Tudor 8.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTCAAGTCTAAGAAACACATG	0.363000													5	240					0	0	0.014758	0	0	
EFHC1	114327	broad.mit.edu	37	6	52288746	52288746	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:52288746A>G	uc003pap.3	+	2	281	c.66A>G	c.(64-66)AAA>AAG	p.K22K	EFHC1_uc011dwv.1_5'UTR|EFHC1_uc011dww.1_Silent_p.K3K	NM_018100	NP_060570	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	22						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			ovary(2)|skin(1)	3	Lung NSC(77;0.109)					TTCTTCAGAAAACAGCCTTCC	0.378000													4	122					0	0	0.014758	0	0	
DST	667	broad.mit.edu	37	6	56434681	56434681	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:56434681A>C	uc003pdf.2	-	48	7522	c.7494T>G	c.(7492-7494)GAT>GAG	p.D2498E	DST_uc003pcz.3_Missense_Mutation_p.D2320E|DST_uc011dxj.1_Missense_Mutation_p.D2349E|DST_uc011dxk.1_Missense_Mutation_p.D2360E|DST_uc003pcy.3_Missense_Mutation_p.D1994E	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	4406					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ATTTTCCTAAATCCTCTGCAC	0.313000													24	190					0	0	0.024334	0	0	
LCA5	167691	broad.mit.edu	37	6	80197201	80197201	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:80197201A>C	uc003pix.2	-	8	2049	c.1614T>G	c.(1612-1614)AAT>AAG	p.N538K	LCA5_uc003piy.2_Missense_Mutation_p.N538K	NM_001122769	NP_001116241	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	538					protein transport	cilium axoneme|microtubule basal body	protein binding				0		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		CATTTCCTGAATTCTGACCTT	0.423000													4	224					0	0	0.021553	0	0	
GABRR1	2569	broad.mit.edu	37	6	89907959	89907959	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:89907959A>C	uc003pna.2	-	5	807	c.352T>G	c.(352-354)TTT>GTT	p.F118V	GABRR1_uc011dzv.1_Missense_Mutation_p.F95V	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	118	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GTCATCGTAAAGTCCTGGGAG	0.557000													22	189					0	0	0.016522	0	0	
ASCC3	10973	broad.mit.edu	37	6	101214491	101214491	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:101214491C>T	uc003pqk.2	-	10	2016	c.1687G>A	c.(1687-1689)GAA>AAA	p.E563K	ASCC3_uc011eai.1_Missense_Mutation_p.E465K|ASCC3_uc003pql.2_Missense_Mutation_p.E563K	NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	563	Helicase ATP-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CCAGTCAATTCTTTCACAATG	0.363000													13	102					0	0	0.013537	0	0	
GRIK2	2898	broad.mit.edu	37	6	102124587	102124587	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:102124587G>T	uc003pqp.3	+	4	880	c.631G>T	c.(631-633)GCA>TCA	p.A211S	GRIK2_uc003pqn.2_Missense_Mutation_p.A211S|GRIK2_uc003pqo.3_Missense_Mutation_p.A211S|GRIK2_uc010kcw.2_Missense_Mutation_p.A211S	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	211	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TACAAAGGATGCAAAACCCTT	0.368000													15	94					1.05317e-09	1.10005e-09	0.020292	1	0	
ZBTB24	9841	broad.mit.edu	37	6	109798005	109798005	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:109798005T>C	uc003ptl.1	-	3	1249	c.1081A>G	c.(1081-1083)ACC>GCC	p.T361A	ZBTB24_uc011ear.1_RNA|ZBTB24_uc010kds.1_Intron|ZBTB24_uc010kdt.1_RNA	NM_014797	NP_055612	O43167	ZBT24_HUMAN	zinc finger and BTB domain containing 24 isoform	361	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0154)|all cancers(137;0.0216)|OV - Ovarian serous cystadenocarcinoma(136;0.0242)|BRCA - Breast invasive adenocarcinoma(108;0.059)		GAGTGCTTGGTGGTCAGAGCC	0.602000													6	34					0	0	0.003080	0	0	
AKD1	221264	broad.mit.edu	37	6	109954220	109954220	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:109954220A>C	uc003ptn.2	-	12	1237	c.1160T>G	c.(1159-1161)ATG>AGG	p.M387R	AKD1_uc003ptr.3_Missense_Mutation_p.M387R	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	387					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TGGTCCTGGCATAGGTGGAAG	0.368000													21	102					0	0	0.018920	0	0	
SLC16A10	117247	broad.mit.edu	37	6	111543321	111543321	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:111543321A>C	uc003pus.2	+	6	1606	c.1431A>C	c.(1429-1431)CAA>CAC	p.Q477H	SLC16A10_uc003put.2_Missense_Mutation_p.Q163H	NM_018593	NP_061063	Q8TF71	MOT10_HUMAN	solute carrier family 16, member 10	477	Extracellular (Potential).				aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity				0		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		GTAAGAAGCAAAGAGAGATCA	0.433000													12	206					0	0	0.013537	0	0	
RFX6	222546	broad.mit.edu	37	6	117245856	117245856	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:117245856T>G	uc003pxm.2	+	15	1643	c.1580T>G	c.(1579-1581)CTT>CGT	p.L527R		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	527					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ATTCGAATGCTTCTCGATGAA	0.388000													6	188					0	0	0.001984	0	0	
ROS1	6098	broad.mit.edu	37	6	117715842	117715842	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:117715842A>C	uc003pxp.1	-	9	1115	c.916T>G	c.(916-918)TTA>GTA	p.L306V	ROS1_uc011ebi.1_RNA|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	306	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AAATGTTTTAAAGATCTCTTT	0.348000			T	GOPC|ROS1	glioblastoma|NSCLC								4	115					0	0	0.009096	0	0	
DCBLD1	285761	broad.mit.edu	37	6	117842710	117842710	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:117842710A>C	uc003pxs.2	+	4	608	c.483A>C	c.(481-483)CGA>CGC	p.R161R	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Silent_p.R161R	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	161	LCCL.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		GTTTGGAACGAGCTAGCCATT	0.318000													9	82					0	0	0.010729	0	0	
L3MBTL3	84456	broad.mit.edu	37	6	130407341	130407341	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:130407341C>T	uc003qbt.2	+	16	1634	c.1464C>T	c.(1462-1464)AAC>AAT	p.N488N	L3MBTL3_uc003qbu.2_Silent_p.N463N	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	488	MBT 3.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		ACAAAAGGAACCCTATGTTTA	0.393000													23	342					0	0	0.014323	0	0	
EPB41L2	2037	broad.mit.edu	37	6	131191232	131191232	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:131191232T>A	uc003qch.2	-	15	2260	c.2078A>T	c.(2077-2079)AAG>ATG	p.K693M	EPB41L2_uc003qce.1_Missense_Mutation_p.K71M|EPB41L2_uc003qcf.1_Intron|EPB41L2_uc003qcg.1_Intron|EPB41L2_uc011eby.1_Intron|EPB41L2_uc003qci.2_Missense_Mutation_p.K623M|EPB41L2_uc010kfk.2_Intron|EPB41L2_uc010kfl.1_Missense_Mutation_p.K623M|EPB41L2_uc003qcd.1_5'Flank|EPB41L2_uc003qcj.1_Missense_Mutation_p.K90M	NM_001431	NP_001422	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	693					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			central_nervous_system(1)|skin(1)	2	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TGCCCGCTTCTTCTCCTCCAC	0.403000													18	130					0	0	0.010504	0	0	
UTRN	7402	broad.mit.edu	37	6	145069618	145069618	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:145069618G>A	uc003qkt.2	+	54	8268	c.8176G>A	c.(8176-8178)GAC>AAC	p.D2726N		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2726	Spectrin 20.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CTTACTCATTGACTCGCTGCA	0.443000													12	73					0	0	0.024245	0	0	
ARID1B	57492	broad.mit.edu	37	6	157256693	157256693	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr6:157256693A>G	uc003qqn.2	+	4	1959	c.1807A>G	c.(1807-1809)AGA>GGA	p.R603G	ARID1B_uc003qqo.2_Missense_Mutation_p.R616G|ARID1B_uc003qqp.2_Missense_Mutation_p.R603G|ARID1B_uc003qqq.1_Missense_Mutation_p.R31G	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	661					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		ACAGCAAGAAAGACCATCAAG	0.373000													4	139					0	0	0.009096	0	0	
SUN1	23353	broad.mit.edu	37	7	892458	892458	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:892458T>G	uc011jvp.1	+	10	1001	c.922T>G	c.(922-924)TTA>GTA	p.L308V	GET4_uc003sjj.1_RNA|SUN1_uc003sjf.2_Missense_Mutation_p.L225V|SUN1_uc011jvq.1_Missense_Mutation_p.L205V|SUN1_uc003sjg.2_Missense_Mutation_p.L213V|SUN1_uc011jvr.1_Missense_Mutation_p.L117V|SUN1_uc003sji.2_Missense_Mutation_p.L146V|SUN1_uc003sjk.2_5'UTR	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	335	Helical.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						AGGTCTCTCCTTACGGGGCCA	0.493000													5	460					0	0	0.001984	0	0	
GLCCI1	113263	broad.mit.edu	37	7	8125957	8125957	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:8125957A>G	uc003srk.2	+	8	1992	c.1433A>G	c.(1432-1434)AAG>AGG	p.K478R		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	478											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		CTTATGCTCAAGAACTCCCCT	0.493000													42	769					0	0	0.011902	0	0	
DNAH11	8701	broad.mit.edu	37	7	21779255	21779255	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:21779255G>A	uc003svc.2	+	49	7930	c.7899G>A	c.(7897-7899)CCG>CCA	p.P2633P		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2633	AAA 3 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GCATGAATCCGATGGTGGGCA	0.423000									Kartagener_syndrome				8	136					0	0	0.006214	0	0	
LOC402644	402644	broad.mit.edu	37	7	28319254	28319254	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:28319254A>C	uc010kuz.1	-	1	65	c.65T>G	c.(64-66)TTT>TGT	p.F22C		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						AAACAGCTCAAAGGAGACGTG	0.502000													3	120					0	0	0.004672	0	0	
CRHR2	1395	broad.mit.edu	37	7	30693214	30693214	+	Silent	SNP	C	T	T	rs143275254		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:30693214C>T	uc003tbn.2	-	12	1342	c.1098G>A	c.(1096-1098)GTG>GTA	p.V366V	CRHR2_uc010kvw.1_3'UTR|CRHR2_uc010kvx.1_Silent_p.V365V|CRHR2_uc010kvy.1_Silent_p.V202V|CRHR2_uc003tbo.2_Silent_p.V352V|CRHR2_uc003tbp.2_Silent_p.V393V	NM_001883	NP_001874	Q13324	CRFR2_HUMAN	corticotropin releasing hormone receptor 2	366	Cytoplasmic (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(2)|ovary(1)|skin(1)	4						CGGCTGAGCGCACCTGTGGGG	0.647000													4	101					0	0	0.009096	0	0	
AMPH	273	broad.mit.edu	37	7	38530710	38530710	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:38530710T>G	uc003tgu.2	-	5	405	c.336A>C	c.(334-336)AAA>AAC	p.K112N	AMPH_uc003tgv.2_Missense_Mutation_p.K112N	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	112	BAR.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CATCCACGAGTTTTTGATGGA	0.393000													44	396					0	0	0.014410	0	0	
C7orf36	57002	broad.mit.edu	37	7	39612132	39612132	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:39612132A>C	uc003thc.3	+	3	517	c.508A>C	c.(508-510)AAC>CAC	p.N170H		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	170											0						GTTTAACAAAAACTGTAGCAA	0.383000													3	237					0	0	0.004672	0	0	
INHBA	3624	broad.mit.edu	37	7	41739626	41739626	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:41739626A>G	uc003thq.2	-	1	582	c.347T>C	c.(346-348)CTT>CCT	p.L116P	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Missense_Mutation_p.L116P|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	116					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CTGCTCCATAAGTTCATTCAT	0.532000										TSP Lung(11;0.080)			54	609					0	0	0.014410	0	0	
GLI3	2737	broad.mit.edu	37	7	42005486	42005486	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:42005486G>A	uc011kbh.1	-	15	3276	c.3185C>T	c.(3184-3186)TCG>TTG	p.S1062L	GLI3_uc011kbg.1_Missense_Mutation_p.S1003L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1062					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ACAGGGGGACGAGTGGAAGTT	0.637000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				9	78					0	0	0.004482	0	0	
HECW1	23072	broad.mit.edu	37	7	43490478	43490478	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:43490478T>G	uc003tid.1	+	12	3055	c.2450T>G	c.(2449-2451)CTG>CGG	p.L817R	HECW1_uc011kbi.1_Intron	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	817					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity	p.R817Q(1)		ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTTCCTTCCCTGAGGCCTGAA	0.428000													4	195					0	0	0.021553	0	0	
HECW1	23072	broad.mit.edu	37	7	43581478	43581478	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:43581478T>G	uc003tid.1	+	26	4734	c.4129T>G	c.(4129-4131)TTG>GTG	p.L1377V	HECW1_uc011kbi.1_Missense_Mutation_p.L1343V	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1377	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GCCCTGTGATTTGAGTGACCT	0.423000													11	158					0	0	0.008291	0	0	
URGCP	55665	broad.mit.edu	37	7	43918314	43918314	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:43918314A>G	uc003tiw.2	-	6	805	c.748T>C	c.(748-750)TTC>CTC	p.F250L	URGCP_uc003tiu.2_Missense_Mutation_p.F207L|URGCP_uc003tiv.2_Missense_Mutation_p.F175L|URGCP_uc003tix.2_Missense_Mutation_p.F241L|URGCP_uc003tiy.2_Missense_Mutation_p.F207L|URGCP_uc003tiz.2_Missense_Mutation_p.F207L|URGCP_uc011kbj.1_Missense_Mutation_p.F207L	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	250					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						TCTTCCCGGAAGCTCCCCATG	0.617000													7	49					0	0	0.001984	0	0	
ADCY1	107	broad.mit.edu	37	7	45688316	45688316	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:45688316C>T	uc003tne.3	+	5	1086	c.1068C>T	c.(1066-1068)TGC>TGT	p.C356C	ADCY1_uc003tnd.2_Silent_p.C131C	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	356	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCTACTACTGCGTGTCGGGCC	0.577000													6	88					0	0	0.021553	0	0	
ABCA13	154664	broad.mit.edu	37	7	48311482	48311482	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:48311482T>G	uc003toq.2	+	17	2244	c.2219T>G	c.(2218-2220)TTT>TGT	p.F740C	ABCA13_uc010kyr.2_Missense_Mutation_p.F243C	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	740					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GTGGAATTTTTTGAGAAATTA	0.368000													6	43					0	0	0.021553	0	0	
ABCA13	154664	broad.mit.edu	37	7	48319313	48319313	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:48319313C>A	uc003toq.2	+	18	8547	c.8522C>A	c.(8521-8523)ACA>AAA	p.T2841K	ABCA13_uc010kys.1_5'Flank	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	2841					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATAACTTCCACAAGAACTTTG	0.353000													25	224					4.72057e-08	4.9161e-08	0.021523	1	0	
POM121L12	285877	broad.mit.edu	37	7	53104142	53104142	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:53104142G>A	uc003tpz.2	+	1	794	c.778G>A	c.(778-780)GCC>ACC	p.A260T		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	260											0						GGTCCAGCCCGCCCCATCCGC	0.657000													10	89					0	0	0.008291	0	0	
CHCHD2	51142	broad.mit.edu	37	7	56170610	56170610	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:56170610T>G	uc003tsa.2	-	3	476	c.395A>C	c.(394-396)AAG>ACG	p.K132T	PSPH_uc003trj.2_Intron	NM_016139	NP_057223	Q9Y6H1	CHCH2_HUMAN	coiled-coil-helix-coiled-coil-helix domain	132	CHCH.					mitochondrion					0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			CTCACAGAGCTTGATGTCACC	0.498000													16	125					0	0	0.024245	0	0	
GTF2IRD1	9569	broad.mit.edu	37	7	73950527	73950527	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:73950527T>C	uc003uaq.2	+	11	1724	c.1331T>C	c.(1330-1332)CTG>CCG	p.L444P	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.L476P|GTF2IRD1_uc003uap.2_Missense_Mutation_p.L444P|GTF2IRD1_uc003uar.1_Missense_Mutation_p.L444P	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	444						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						ACCACGAAGCTGGAGCCAGCC	0.642000													5	92					0	0	0.014758	0	0	
NCF1	653361	broad.mit.edu	37	7	74193722	74193722	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:74193722T>G	uc003ubb.2	+	4	419	c.349T>G	c.(349-351)TTC>GTC	p.F117V	NCF1_uc010lbs.1_Missense_Mutation_p.F117V|NCF1_uc011kfh.1_Intron	NM_000265	NP_000256	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	117	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			skin(1)	1						CCTCCTCGACTTCTTCAAGGT	0.502000													5	69					0	0	0.021553	0	0	
AKAP9	10142	broad.mit.edu	37	7	91667822	91667822	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:91667822A>C	uc003ulg.2	+	17	4653	c.4428A>C	c.(4426-4428)CAA>CAC	p.Q1476H	AKAP9_uc003ule.2_Missense_Mutation_p.Q1488H|AKAP9_uc003ulf.2_Missense_Mutation_p.Q1476H|AKAP9_uc003uli.2_Missense_Mutation_p.Q1101H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	1488					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CATCAAAGCAAGCACATGCTG	0.338000			T	BRAF	papillary thyroid								16	137					0	0	0.028581	0	0	
AKAP9	10142	broad.mit.edu	37	7	91730334	91730334	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:91730334A>C	uc003ulg.2	+	45	11286	c.11061A>C	c.(11059-11061)CAA>CAC	p.Q3687H	AKAP9_uc003ulf.2_Missense_Mutation_p.Q3679H|AKAP9_uc003uli.2_Missense_Mutation_p.Q3310H|AKAP9_uc003ulj.2_Missense_Mutation_p.Q1457H|AKAP9_uc003ull.2_Missense_Mutation_p.Q583H	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	3691					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CTTTACTTCAAACTCTGAGCC	0.388000			T	BRAF	papillary thyroid								8	176					0	0	0.004482	0	0	
SAMD9	54809	broad.mit.edu	37	7	92734770	92734770	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:92734770T>G	uc003umf.2	-	3	897	c.641A>C	c.(640-642)AAA>ACA	p.K214T	SAMD9_uc003umg.2_Missense_Mutation_p.K214T	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	214						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ATTGCTAAATTTCATCTTGAC	0.408000													5	389					0	0	0.003080	0	0	
SAMD9L	219285	broad.mit.edu	37	7	92764157	92764157	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:92764157A>G	uc003umh.1	-	5	2344	c.1128T>C	c.(1126-1128)TCT>TCC	p.S376S	SAMD9L_uc003umj.1_Silent_p.S376S|SAMD9L_uc003umi.1_Silent_p.S376S|SAMD9L_uc010lfb.1_Silent_p.S376S|SAMD9L_uc003umk.1_Silent_p.S376S|SAMD9L_uc010lfc.1_Silent_p.S376S|SAMD9L_uc010lfd.1_Silent_p.S376S|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	376										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CCTCTTTTCTAGATGCTACCA	0.423000													17	559					0	0	0.008871	0	0	
ARPC1B	10095	broad.mit.edu	37	7	98985726	98985726	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:98985726G>A	uc003upz.2	+	4	323	c.234G>A	c.(232-234)GTG>GTA	p.V78V	ARPC1A_uc011kit.1_RNA|ARPC1B_uc003uqa.2_Silent_p.V78V|ARPC1B_uc003uqb.2_Silent_p.V78V|ARPC1B_uc003uqc.2_Silent_p.V78V|ARPC1B_uc003uqd.2_5'Flank	NM_005720	NP_005711	O15143	ARC1B_HUMAN	actin related protein 2/3 complex subunit 1B	78	WD 2.				cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton				0	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			ACGCCTACGTGTGGACGCTGA	0.642000													9	125					0	0	0.013537	0	0	
CYP3A43	64816	broad.mit.edu	37	7	99447302	99447302	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:99447302T>G	uc003urx.1	+	7	758	c.655T>G	c.(655-657)TTT>GTT	p.F219V	CYP3A43_uc003ury.1_Missense_Mutation_p.F219V|CYP3A43_uc003urz.1_Missense_Mutation_p.F219V|CYP3A43_uc003usa.1_RNA|CYP3A43_uc010lgi.1_Intron|CYP3A43_uc003usb.1_Missense_Mutation_p.L81R	NM_057095	NP_476436	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A,	219			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TTTGGATCCCTTTTTACTCTT	0.219000													4	130					0	0	0.014758	0	0	
MCM7	4176	broad.mit.edu	37	7	99693469	99693469	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:99693469G>A	uc003usw.1	-	11	2033	c.1523C>T	c.(1522-1524)CCT>CTT	p.P508L	MCM7_uc003usv.1_Missense_Mutation_p.P332L|MCM7_uc003usx.1_Missense_Mutation_p.P332L|uc003usy.1_5'Flank|MIR25_hsa-mir-25|MI0000082_5'Flank|uc003usz.1_5'Flank|MIR93_hsa-mir-93|MI0000095_5'Flank|uc003uta.1_5'Flank|MIR106B_hsa-mir-106b|MI0000734_5'Flank	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	508	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CAGTGCAGCAGGTAGCTGTAT	0.607000													28	218					0	0	0.024334	0	0	
MUC17	140453	broad.mit.edu	37	7	100679619	100679619	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:100679619C>T	uc003uxp.1	+	3	4975	c.4922C>T	c.(4921-4923)ACG>ATG	p.T1641M	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1641	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|25.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTCAGCACCACGCCGGTGGCC	0.488000													68	573					0	0	0.014410	0	0	
LAMB4	22798	broad.mit.edu	37	7	107748104	107748104	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:107748104G>A	uc010ljo.1	-	6	647	c.563C>T	c.(562-564)TCG>TTG	p.S188L	LAMB4_uc003vey.2_Missense_Mutation_p.S188L	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	188	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TTCAATATCCGAGTATTTGGA	0.348000													25	97					0	0	0.018920	0	0	
CFTR	1080	broad.mit.edu	37	7	117235072	117235072	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:117235072T>G	uc003vjd.2	+	15	2711	c.2579T>G	c.(2578-2580)ATT>AGT	p.I860S	CFTR_uc011knq.1_Missense_Mutation_p.I266S	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	860	Helical; Name=7; (Potential).|ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AAGAGCTTAATTTTTGTGCTA	0.338000									Cystic_Fibrosis				3	148					0	0	0.004672	0	0	
CFTR	1080	broad.mit.edu	37	7	117243768	117243768	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:117243768T>G	uc003vjd.2	+	17	2972	c.2840T>G	c.(2839-2841)ATT>AGT	p.I947S	CFTR_uc011knq.1_Missense_Mutation_p.I353S	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	947	Cytoplasmic (Potential).|ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GTGTCGAAAATTTTACACCAC	0.403000									Cystic_Fibrosis				5	284					0	0	0.014758	0	0	
WNT16	51384	broad.mit.edu	37	7	120965524	120965524	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:120965524A>G	uc003vjv.2	+	1	104	c.55A>G	c.(55-57)ACC>GCC	p.T19A		NM_016087	NP_057171	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family,	Error:Variant_position_missing_in_Q9UBV4_after_alignment					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			lung(2)|ovary(2)|large_intestine(1)	5	all_neural(327;0.117)					TTCTCAAAAGACCTCCCTATG	0.448000													10	264					0	0	0.008291	0	0	
FEZF1	389549	broad.mit.edu	37	7	121942244	121942244	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:121942244T>G	uc003vkd.2	-	4	1309	c.1235A>C	c.(1234-1236)AAC>ACC	p.N412T	FEZF1_uc003vkc.2_Missense_Mutation_p.N362T|uc010lko.1_5'Flank	NM_001024613	NP_001019784	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1 isoform 1	412	C2H2-type 6.				cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)	3						GAGGTCAAAGTTCCTGCAGAA	0.542000													5	176					0	0	0.021553	0	0	
LMOD2	442721	broad.mit.edu	37	7	123302476	123302476	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:123302476T>C	uc003vky.2	+	2	993	c.836T>C	c.(835-837)TTC>TCC	p.F279S		NM_207163	NP_997046	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	279						cytoskeleton	actin binding|tropomyosin binding				0						GAGTCCAACTTCATAACGGGA	0.547000													4	142					0	0	0.009096	0	0	
PAX4	5078	broad.mit.edu	37	7	127253104	127253104	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:127253104C>T	uc010lld.1	-	6	869	c.663G>A	c.(661-663)GAG>GAA	p.E221E	PAX4_uc003vmf.2_Silent_p.E219E|PAX4_uc003vmg.1_Silent_p.E221E|PAX4_uc003vmh.2_Silent_p.E219E	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	229	Homeobox.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						ACTTGAGCTTCTCTTGCCGAC	0.448000													30	68					0	0	0.015359	0	0	
PLXNA4	91584	broad.mit.edu	37	7	131815261	131815261	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:131815261T>G	uc003vra.3	-	32	5891	c.5662A>C	c.(5662-5664)ACC>CCC	p.T1888P	PLXNA4_uc003vqz.3_Missense_Mutation_p.T173P	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1888	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CTCATGAGGGTTATGACTTGT	0.532000													48	176					0	0	0.014410	0	0	
ATP6V0A4	50617	broad.mit.edu	37	7	138455901	138455901	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:138455901T>C	uc003vuf.2	-	2	330	c.92A>G	c.(91-93)GAG>GGG	p.E31G	ATP6V0A4_uc003vug.2_Missense_Mutation_p.E31G|ATP6V0A4_uc003vuh.2_Missense_Mutation_p.E31G	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit	31	Cytoplasmic (Potential).				cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			pancreas(1)	1						CAATCCGAGCTCTCCGAGCTC	0.478000													41	514					0	0	0.014410	0	0	
LUC7L2	51631	broad.mit.edu	37	7	139092001	139092001	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:139092001G>A	uc003vux.2	+	6	966	c.592G>A	c.(592-594)GGA>AGA	p.G198R	LUC7L2_uc011kqs.1_Missense_Mutation_p.G195R|LUC7L2_uc011kqt.1_Missense_Mutation_p.G264R|LUC7L2_uc003vuy.2_Missense_Mutation_p.G197R|LUC7L2_uc003vuz.1_Missense_Mutation_p.G145R|LUC7L2_uc003vva.2_Missense_Mutation_p.G145R	NM_016019	NP_057103	Q9Y383	LC7L2_HUMAN	LUC7-like 2	198	C2H2-type; atypical.						enzyme binding|metal ion binding				0	Melanoma(164;0.242)					TGCCTATTTAGGACTTCATGA	0.398000													15	196					0	0	0.024245	0	0	
BRAF	673	broad.mit.edu	37	7	140453134	140453134	+	Missense_Mutation	SNP	T	C	C	rs121913377		TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:140453134T>C	uc003vwc.3	-	15	1862	c.1801A>G	c.(1801-1803)AAA>GAA	p.K601E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	601	Protein kinase.		K -> Q (in CFC syndrome).|K -> E (in colorectal cancer).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.K601E(47)|p.V600_K601>E(8)|p.K601N(7)|p.K601del(4)|p.K601Q(3)|p.T599_R603>I(2)|p.V600_W604del(1)|p.K601K(1)|p.K601L(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.K601I(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	CATCGAGATTTCACTGTAGCT	0.368000		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				19	150					0	0	0.008871	0	0	
TAS2R5	54429	broad.mit.edu	37	7	141491039	141491039	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:141491039C>T	uc003vwr.1	+	1	1023	c.878C>T	c.(877-879)GCT>GTT	p.A293V		NM_018980	NP_061853	Q9NYW4	TA2R5_HUMAN	taste receptor T2R5	293	Cytoplasmic (Potential).				chemosensory behavior|sensory perception of taste		taste receptor activity				0	Melanoma(164;0.0171)					ACAGTGTGTGCTCGGAGATGC	0.493000													6	220					0	0	0.021553	0	0	
PRSS1	5644	broad.mit.edu	37	7	142460771	142460771	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:142460771C>T	uc003wak.2	+	5	661	c.644C>T	c.(643-645)TCC>TTC	p.S215F	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.S155F	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	215	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GGAGTTGTCTCCTGGGGTGAT	0.502000									Hereditary_Pancreatitis				7	207					0	0	0.001984	0	0	
ZNF425	155054	broad.mit.edu	37	7	148801048	148801048	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:148801048A>T	uc003wfj.2	-	4	1988	c.1915T>A	c.(1915-1917)TCT>ACT	p.S639T		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	639	C2H2-type 16.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			ATCACACAAGAGAATGGCTTT	0.537000													27	327					0	0	0.006320	0	0	
MLL3	58508	broad.mit.edu	37	7	151860106	151860106	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr7:151860106G>A	uc003wla.2	-	43	10775	c.10556C>T	c.(10555-10557)TCA>TTA	p.S3519L	MLL3_uc003wkz.2_Missense_Mutation_p.S2580L|MLL3_uc003wky.2_Missense_Mutation_p.S1028L	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3519					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GATTGATGGTGAATCAGGAAC	0.468000			N		medulloblastoma								5	373					0	0	0.014758	0	0	
MYOM2	9172	broad.mit.edu	37	8	2063895	2063895	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:2063895T>A	uc003wpx.3	+	26	3462	c.3324T>A	c.(3322-3324)GAT>GAA	p.D1108E	MYOM2_uc011kwi.1_Missense_Mutation_p.D533E	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1108					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TTATTGGAGATGGTATGCTAT	0.343000													22	120					0	0	0.018920	0	0	
XKR6	286046	broad.mit.edu	37	8	10755462	10755462	+	Nonstop_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:10755462T>G	uc003wtk.1	-	3	1953	c.1926A>C	c.(1924-1926)TAA>TAC	p.*642Y		NM_173683	NP_775954	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related	642						integral to membrane				ovary(1)|skin(1)	2				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CAAGATGCTCTTAGAGTGAAG	0.448000													21	131					0	0	0.018920	0	0	
FBXO16	157574	broad.mit.edu	37	8	28340913	28340913	+	Silent	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:28340913T>A	uc003xgu.2	-	2	149	c.51A>T	c.(49-51)ACA>ACT	p.T17T	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Silent_p.T16T|FBXO16_uc003xgw.2_Silent_p.T16T	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	17										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		TGCTCATCTTTGTCTGCATTT	0.398000													8	313					0	0	0.006214	0	0	
WHSC1L1	54904	broad.mit.edu	37	8	38146168	38146168	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:38146168T>C	uc003xli.2	-	19	3856	c.3338A>G	c.(3337-3339)GAG>GGG	p.E1113G	WHSC1L1_uc011lbm.1_Missense_Mutation_p.E1113G|WHSC1L1_uc010lwe.2_Missense_Mutation_p.E1064G	NM_023034	NP_075447	Q9BZ95	NSD3_HUMAN	WHSC1L1 protein isoform long	1113	AWS.				cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)	1	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			GTTCAGGCACTCCGATTCCAA	0.498000			T	NUP98	AML								3	117					0	0	0.014758	0	0	
PTTG3P	26255	broad.mit.edu	37	8	67679829	67679829	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:67679829G>A	uc011leu.1	-	1	412	c.412C>T	c.(412-414)CAT>TAT	p.H138Y	SGK3_uc003xwp.2_Intron|SGK3_uc003xwr.2_Intron	NR_002734				RecName: Full=Securin-3; AltName: Full=Pituitary tumor transforming gene 3 protein;          Short=hPTTG3; AltName: Full=rcPTTG1;												0						AAGGGGAGATGTGCAATCTGG	0.478000													4	132					0	0	0.009096	0	0	
KCNB2	9312	broad.mit.edu	37	8	73848915	73848915	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:73848915G>A	uc003xzb.2	+	3	1913	c.1325G>A	c.(1324-1326)CGG>CAG	p.R442Q		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	442	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			GCTCTTGAGCGGGCCAAAAGG	0.448000													26	144					0	0	0.021523	0	0	
MATN2	4147	broad.mit.edu	37	8	99030226	99030226	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:99030226A>G	uc003yic.2	+	12	1932	c.1701A>G	c.(1699-1701)AAA>AAG	p.K567K	MATN2_uc010mbh.1_Silent_p.K526K|MATN2_uc003yid.2_Silent_p.K567K|MATN2_uc003yie.1_Silent_p.K567K|MATN2_uc010mbi.1_Silent_p.K400K|MATN2_uc010mbj.1_Silent_p.K66K	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	567	EGF-like 9.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			CTTCAGGGAAAGATGTCTGCC	0.483000													59	468					0	0	0.014410	0	0	
RIMS2	9699	broad.mit.edu	37	8	105026758	105026758	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:105026758C>T	uc003yls.2	+	17	2710	c.2469C>T	c.(2467-2469)GTC>GTT	p.V823V	RIMS2_uc003ylp.2_Silent_p.V1083V|RIMS2_uc003ylw.2_Silent_p.V897V|RIMS2_uc003ylq.2_Silent_p.V897V|RIMS2_uc003ylr.2_Silent_p.V922V	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1145					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTGGGTCTGTCCAGACAAGCC	0.413000										HNSCC(12;0.0054)			4	67					0	0	0.009096	0	0	
TM7SF4	81501	broad.mit.edu	37	8	105361784	105361784	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:105361784A>G	uc003ylx.1	+	2	1053	c.1004A>G	c.(1003-1005)GAG>GGG	p.E335G		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	335					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCAGGGTTTGAGGTTCACTTG	0.363000													39	290					0	0	0.021022	0	0	
EBAG9	9166	broad.mit.edu	37	8	110569190	110569190	+	Missense_Mutation	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:110569190G>T	uc003ynf.2	+	5	583	c.348G>T	c.(346-348)TTG>TTT	p.L116F	EBAG9_uc010mcn.1_RNA|EBAG9_uc003yng.2_Missense_Mutation_p.L116F	NM_198120	NP_936056	O00559	RCAS1_HUMAN	estrogen receptor binding site associated	116	Cytoplasmic (Potential).				apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity				0			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)			GAGAACCATTGAATTTTGGCA	0.328000													4	88					1.23904e-05	1.27714e-05	0.014758	1	0	
KLHL38	340359	broad.mit.edu	37	8	124664441	124664441	+	Silent	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:124664441C>A	uc003yqs.1	-	1	750	c.726G>T	c.(724-726)CTG>CTT	p.L242L		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	242											0						GCGAGGACTGCAGGAGGGCAT	0.557000													8	112					2.74318e-10	2.87809e-10	0.006214	1	0	
FAM91A1	157769	broad.mit.edu	37	8	124801950	124801950	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:124801950T>G	uc003yqv.2	+	15	1437	c.1376T>G	c.(1375-1377)GTT>GGT	p.V459G	FAM91A1_uc011lik.1_Missense_Mutation_p.V459G|FAM91A1_uc011lil.1_Missense_Mutation_p.V217G	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	459										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			AAAGATCTAGTTGCGCAAACT	0.348000													25	113					0	0	0.016522	0	0	
FER1L6	654463	broad.mit.edu	37	8	124985675	124985675	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:124985675T>C	uc003yqw.2	+	7	655	c.449T>C	c.(448-450)GTC>GCC	p.V150A		NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	150	C2 1.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTCCTCAGGTCTTTCACCAC	0.493000													16	107					0	0	0.006122	0	0	
BAI1	575	broad.mit.edu	37	8	143623495	143623495	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr8:143623495C>T	uc003ywm.2	+	27	4083	c.3900C>T	c.(3898-3900)CCC>CCT	p.P1300P		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1300	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GGCCCCTGCCCGACTTCCCCA	0.647000													6	39					0	0	0.001984	0	0	
PTPRD	5789	broad.mit.edu	37	9	8521506	8521506	+	Missense_Mutation	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:8521506A>T	uc003zkk.2	-	19	1443	c.732T>A	c.(730-732)AAT>AAA	p.N244K	PTPRD_uc003zkp.2_Missense_Mutation_p.N244K|PTPRD_uc003zkq.2_Missense_Mutation_p.N244K|PTPRD_uc003zkr.2_Missense_Mutation_p.N238K|PTPRD_uc003zks.2_Missense_Mutation_p.N234K|PTPRD_uc003zkl.2_Missense_Mutation_p.N244K|PTPRD_uc003zkm.2_Missense_Mutation_p.N231K|PTPRD_uc003zkn.2_Missense_Mutation_p.N244K|PTPRD_uc003zko.2_Missense_Mutation_p.N241K	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	244	Extracellular (Potential).|Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGATTTCATGATTAGTGGGTG	0.453000										TSP Lung(15;0.13)			13	113					0	0	0.020292	0	0	
NFIB	4781	broad.mit.edu	37	9	14307364	14307364	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:14307364G>A	uc003zle.2	-	2	621	c.186C>T	c.(184-186)CTC>CTT	p.L62L	NFIB_uc003zlf.2_Silent_p.L62L|NFIB_uc011lmo.1_Silent_p.L62L	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	62	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		GCTTTTCACTGAGAAGCTCAT	0.458000			T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								28	167					0	0	0.008361	0	0	
PTPLAD2	401494	broad.mit.edu	37	9	21029331	21029331	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:21029331A>G	uc010miq.1	-	2	151	c.105T>C	c.(103-105)TTT>TTC	p.F35F	PTPLAD2_uc003zoj.1_5'UTR|PTPLAD2_uc010mir.1_Silent_p.F35F	NM_001010915	NP_001010915	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain	35	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			skin(1)	1				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		TCATATTTGTAAATATCCAAG	0.313000													6	202					0	0	0.021553	0	0	
IFNA5	3442	broad.mit.edu	37	9	21304795	21304795	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:21304795A>G	uc011lnh.1	-	1	461	c.461T>C	c.(460-462)CTG>CCG	p.L154P		NM_002169	NP_002160	P01569	IFNA5_HUMAN	interferon, alpha 5 precursor	154					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			ovary(1)	1				Lung(24;2.34e-24)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		CTTCTCTGTCAGATAGAGGGT	0.438000													25	556					0	0	0.018920	0	0	
AQP7	364	broad.mit.edu	37	9	33385656	33385656	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:33385656T>A	uc003zst.2	-	7	906	c.734A>T	c.(733-735)CAG>CTG	p.Q245L	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Missense_Mutation_p.Q188L|AQP7_uc010mjs.2_Missense_Mutation_p.Q153L|AQP7_uc010mjt.2_Missense_Mutation_p.Q153L|AQP7_uc011lnx.1_Missense_Mutation_p.Q245L|AQP7_uc011lny.1_Missense_Mutation_p.Q244L|AQP7_uc003zss.3_Missense_Mutation_p.Q153L|AQP7_uc011lnz.1_Missense_Mutation_p.Q153L|AQP7_uc011loa.1_Silent_p.T113T	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	245	Extracellular (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCTGAAGACCTGTTTGCCCCA	0.597000													4	157					0	0	0.001984	0	0	
UBAP2	55833	broad.mit.edu	37	9	33943446	33943446	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:33943446G>A	uc003ztq.1	-	15	1800	c.1687C>T	c.(1687-1689)CCC>TCC	p.P563S	UBAP2_uc011loc.1_Missense_Mutation_p.P472S|UBAP2_uc011lod.1_Missense_Mutation_p.P296S|UBAP2_uc011loe.1_Missense_Mutation_p.P318S|UBAP2_uc011lof.1_Missense_Mutation_p.P488S|UBAP2_uc011log.1_Missense_Mutation_p.P509S|UBAP2_uc003ztr.2_Missense_Mutation_p.P435S|UBAP2_uc003zts.2_Missense_Mutation_p.P196S	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	563										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		AAGCTGATGGGAATCTGATTA	0.393000													4	168					0	0	0.009096	0	0	
TMEM8B	51754	broad.mit.edu	37	9	35846984	35846984	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:35846984T>G	uc003zym.2	+	11	1826	c.811T>G	c.(811-813)TTC>GTC	p.F271V	TMEM8B_uc003zyk.2_Missense_Mutation_p.F271V|TMEM8B_uc003zyl.2_Missense_Mutation_p.F438V|TMEM8B_uc003zyn.2_Missense_Mutation_p.L166R|TMEM8B_uc003zyo.2_Missense_Mutation_p.F271V	NM_001042589	NP_001036054	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B isoform a	271	Helical; (Potential).				cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			ovary(1)	1						CACCATGTTCTTCTCCACGGT	0.547000													5	257					0	0	0.014758	0	0	
RECK	8434	broad.mit.edu	37	9	36112368	36112368	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:36112368G>A	uc003zyv.2	+	16	2041	c.1955G>A	c.(1954-1956)AGT>AAT	p.S652N	RECK_uc003zyw.2_Missense_Mutation_p.S524N|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	652	Kazal-like 1.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			ACTTACCCCAGTGCCTGCATT	0.488000													10	141					0	0	0.010729	0	0	
ZCCHC7	84186	broad.mit.edu	37	9	37356915	37356915	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:37356915A>G	uc003zzq.2	+	9	1455	c.1282A>G	c.(1282-1284)AGG>GGG	p.R428G	ZCCHC7_uc011lqh.1_Missense_Mutation_p.R138G|ZCCHC7_uc011lqi.1_Missense_Mutation_p.R427G|ZCCHC7_uc010mlt.2_Missense_Mutation_p.R427G	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	428							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		CCATGATATAAGGAAGGGCCG	0.398000													5	93					0	0	0.014758	0	0	
ZNF658	26149	broad.mit.edu	37	9	40784134	40784134	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:40784134C>A	uc004abs.2	-	4	363	c.211G>T	c.(211-213)GAT>TAT	p.D71Y	ZNF658_uc010mmm.1_Missense_Mutation_p.D71Y|ZNF658_uc010mmn.1_Missense_Mutation_p.D71Y	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AGGAATTCATCTTCTAAAGAC	0.433000													12	72					0.000308642	0.000315361	0.024245	1	0	
TRPM3	80036	broad.mit.edu	37	9	73151027	73151027	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:73151027T>C	uc004aid.2	-	25	5210	c.4966A>G	c.(4966-4968)ATC>GTC	p.I1656V	TRPM3_uc004ahu.2_Missense_Mutation_p.I1498V|TRPM3_uc004ahv.2_Missense_Mutation_p.I1458V|TRPM3_uc004ahw.2_Missense_Mutation_p.I1528V|TRPM3_uc004ahx.2_Missense_Mutation_p.I1515V|TRPM3_uc004ahy.2_Missense_Mutation_p.I1518V|TRPM3_uc004ahz.2_Missense_Mutation_p.I1505V|TRPM3_uc004aia.2_Missense_Mutation_p.I1503V|TRPM3_uc004aib.2_Missense_Mutation_p.I1493V|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1681	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TTGTCACTGATGGAGAAGCTC	0.577000													10	536					0	0	0.013537	0	0	
TRPM3	80036	broad.mit.edu	37	9	73151754	73151754	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:73151754A>C	uc004aid.2	-	25	4483	c.4239T>G	c.(4237-4239)GAT>GAG	p.D1413E	TRPM3_uc004ahu.2_Missense_Mutation_p.D1255E|TRPM3_uc004ahv.2_Missense_Mutation_p.D1215E|TRPM3_uc004ahw.2_Missense_Mutation_p.D1285E|TRPM3_uc004ahx.2_Missense_Mutation_p.D1272E|TRPM3_uc004ahy.2_Missense_Mutation_p.D1275E|TRPM3_uc004ahz.2_Missense_Mutation_p.D1262E|TRPM3_uc004aia.2_Missense_Mutation_p.D1260E|TRPM3_uc004aib.2_Missense_Mutation_p.D1250E|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1438	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						GAGGGTCTATATCACAGTGGA	0.507000													7	174					0	0	0.003080	0	0	
ALDH1A1	216	broad.mit.edu	37	9	75567908	75567908	+	Silent	SNP	G	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:75567908G>T	uc004ajd.2	-	1	62	c.9C>A	c.(7-9)TCC>TCA	p.S3S	ALDH1A1_uc011lsh.1_Intron	NM_000689	NP_000680	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1A1	3					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			ovary(3)|lung(1)	4					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GCGTGCCTGAGGATGACATTT	0.428000													13	103					1.5739e-10	1.65624e-10	0.028581	1	0	
PRUNE2	158471	broad.mit.edu	37	9	79325825	79325825	+	Silent	SNP	A	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:79325825A>T	uc010mpk.2	-	8	1489	c.1365T>A	c.(1363-1365)GGT>GGA	p.G455G		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	455					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						GAGGCCCAGCACCTTCTCCCA	0.607000													4	50					0	0	0.009096	0	0	
FLJ46321	389763	broad.mit.edu	37	9	84607680	84607680	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:84607680C>T	uc004amn.2	+	4	2342	c.2295C>T	c.(2293-2295)TCC>TCT	p.S765S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	765						integral to membrane					0						ATATGCTTTCCATGGAGAATG	0.468000													11	111					0	0	0.010729	0	0	
C9orf103	414328	broad.mit.edu	37	9	86258448	86258448	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:86258448A>G	uc004amu.1	+	5	331	c.317A>G	c.(316-318)GAG>GGG	p.E106G	C9orf103_uc004amt.1_Missense_Mutation_p.E60G|C9orf103_uc010mpv.1_Missense_Mutation_p.E60G	NM_001001551	NP_001001551	Q5T6J7	GNTK_HUMAN	gluconokinase-like protein	106					carbohydrate metabolic process	cytoplasm	ATP binding|gluconokinase activity|shikimate kinase activity				0						CTGAAGTGTGAGGAGTCGGGA	0.512000													3	143					0	0	0.004672	0	0	
KIF27	55582	broad.mit.edu	37	9	86457159	86457159	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:86457159T>G	uc004ana.2	-	17	3858	c.3714A>C	c.(3712-3714)CCA>CCC	p.P1238P	KIF27_uc010mpw.2_Silent_p.P1172P|KIF27_uc010mpx.2_Silent_p.P1141P	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	1238					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						TACACTCTGATGGTGCTAGTT	0.408000													3	148					0	0	0.009096	0	0	
FAM75C1	441452	broad.mit.edu	37	9	90536533	90536533	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:90536533A>C	uc010mqi.2	+	4	1740	c.1711A>C	c.(1711-1713)AGA>CGA	p.R571R	FAM75C1_uc004apq.3_Silent_p.R554R	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						TGATTTATTAAGACGCACAGA	0.527000													6	231					0	0	0.021553	0	0	
ZNF782	158431	broad.mit.edu	37	9	99580994	99580994	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:99580994T>G	uc004awp.1	-	6	1592	c.1311A>C	c.(1309-1311)CTA>CTC	p.L437L	ZNF782_uc011lup.1_Silent_p.L305L	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	437	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				GGTGTATTCTTAGGCCTGACT	0.418000													6	403					0	0	0.021553	0	0	
TEX10	54881	broad.mit.edu	37	9	103111616	103111616	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:103111616A>C	uc004bas.2	-	2	245	c.30T>G	c.(28-30)GAT>GAG	p.D10E	TEX10_uc011lvf.1_5'Flank|TEX10_uc011lvg.1_Missense_Mutation_p.D13E|TEX10_uc011lvh.1_Intron|TEX10_uc004bat.2_Missense_Mutation_p.D10E	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	10						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CTTTTTGAAAATCATGTTGGC	0.294000													5	75					0	0	0.014758	0	0	
TMEFF1	8577	broad.mit.edu	37	9	103204421	103204421	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:103204421C>T	uc004bay.1	+	1	234	c.201C>T	c.(199-201)TTC>TTT	p.F67F	C9orf30_uc004baw.2_Silent_p.F67F|C9orf30_uc004bax.2_RNA	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	Error:Variant_position_missing_in_Q8IYR6_after_alignment					multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				TGCGGGATTTCAAACAGCTGA	0.527000													8	78					0	0	0.004482	0	0	
SLC44A1	23446	broad.mit.edu	37	9	108136917	108136917	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:108136917C>A	uc004bcn.2	+	13	1754	c.1533C>A	c.(1531-1533)TTC>TTA	p.F511L	SLC44A1_uc010mtk.1_Missense_Mutation_p.F511L|SLC44A1_uc004bco.1_Missense_Mutation_p.F303L	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	511	Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	GCACCAACTTCTGCACCTCAG	0.413000													70	263					5.02462e-34	5.37589e-34	0.014410	1	0	
LPAR1	1902	broad.mit.edu	37	9	113637849	113637849	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:113637849T>G	uc004bfa.2	-	5	1202	c.947A>C	c.(946-948)AAA>ACA	p.K316T	LPAR1_uc011lwm.1_Missense_Mutation_p.K317T|LPAR1_uc004bfb.2_Missense_Mutation_p.K316T|LPAR1_uc004bfc.2_Missense_Mutation_p.K316T|LPAR1_uc011lwn.1_Missense_Mutation_p.K298T|LPAR1_uc011lwo.1_Missense_Mutation_p.K317T|LPAR1_uc010mub.2_Missense_Mutation_p.K316T	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	316	Cytoplasmic (Potential).				positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GCTCATTTCTTTGTCGCGGTA	0.557000													7	234					0	0	0.001984	0	0	
LPAR1	1902	broad.mit.edu	37	9	113704450	113704450	+	Splice_Site	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:113704450T>C	uc004bfa.2	-	4	301	c.46_splice	c.e4-1	p.F16_splice	LPAR1_uc011lwm.1_Splice_Site_p.F17_splice|LPAR1_uc004bfb.2_Splice_Site_p.F16_splice|LPAR1_uc004bfc.2_Splice_Site_p.F16_splice|LPAR1_uc011lwn.1_Splice_Site|LPAR1_uc011lwo.1_Splice_Site_p.F17_splice|LPAR1_uc010mub.2_Splice_Site_p.F16_splice	NM_057159	NP_476500	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1						positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				ovary(2)	2						GGCTGTGAACTAAAAGAAAAA	0.368000													6	111					0	0	0.021553	0	0	
SNX30	401548	broad.mit.edu	37	9	115579987	115579987	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:115579987T>C	uc004bgj.3	+	3	499	c.351T>C	c.(349-351)AGT>AGC	p.S117S		NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	117	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						CTTTGCAGAGTACTCGGGTGG	0.428000													6	109					0	0	0.001984	0	0	
DBC1	1620	broad.mit.edu	37	9	121929915	121929915	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:121929915G>A	uc004bkc.2	-	8	2189	c.1733C>T	c.(1732-1734)CCC>CTC	p.P578L		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	578					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TTCCCCGAAGGGCATGTTCCA	0.542000													13	118					0	0	0.013537	0	0	
NDUFA8	4702	broad.mit.edu	37	9	124914536	124914536	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:124914536A>G	uc004blv.2	-	2	345	c.203T>C	c.(202-204)TTG>TCG	p.L68S		NM_014222	NP_055037	P51970	NDUA8_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	68	CHCH 1.				mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)	1					NADH(DB00157)	AAAGAAGTCCAAAGCACACTT	0.413000													8	96					0	0	0.003080	0	0	
SCAI	286205	broad.mit.edu	37	9	127790688	127790688	+	Missense_Mutation	SNP	C	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:127790688C>A	uc004bpe.2	-	5	477	c.396G>T	c.(394-396)CAG>CAT	p.Q132H	SCAI_uc004bpd.2_Missense_Mutation_p.Q155H|SCAI_uc010mwu.2_RNA	NM_001144877	NP_001138349	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion isoform 2	132	Required for interaction with MKL1 (By similarity).|Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			ovary(2)|breast(2)|central_nervous_system(1)	5						GATAGTATAGCTGCCCAATCT	0.338000													9	114					2.52707e-12	2.66326e-12	0.006214	1	0	
PTGES2	80142	broad.mit.edu	37	9	130884681	130884681	+	Missense_Mutation	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:130884681C>T	uc004bti.2	-	6	1443	c.965G>A	c.(964-966)CGG>CAG	p.R322Q	PTGES2_uc004btj.2_RNA|PTGES2_uc004btk.2_Missense_Mutation_p.R131Q|PTGES2_uc004btl.2_Missense_Mutation_p.R131Q|PTGES2_uc004btm.2_RNA	NM_025072	NP_079348	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	322	GST C-terminal.|Cytoplasmic (Potential).				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity				0						CATGAAGGGCCGGTCCTTGCC	0.647000													18	122					0	0	0.004990	0	0	
SPTAN1	6709	broad.mit.edu	37	9	131346634	131346634	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:131346634A>C	uc004bvl.3	+	17	2380	c.2267A>C	c.(2266-2268)AAG>ACG	p.K756T	SPTAN1_uc011mbg.1_Missense_Mutation_p.K756T|SPTAN1_uc011mbh.1_Missense_Mutation_p.K768T|SPTAN1_uc004bvm.3_Missense_Mutation_p.K756T|SPTAN1_uc004bvn.3_Missense_Mutation_p.K756T	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	756	Spectrin 8.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GAAAACATCAAGAAGAAACAG	0.547000													5	84					0	0	0.001984	0	0	
CCBL1	883	broad.mit.edu	37	9	131600576	131600576	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:131600576A>G	uc004bwh.2	-	4	457	c.272T>C	c.(271-273)CTC>CCC	p.L91P	CCBL1_uc004bwf.2_Missense_Mutation_p.L125P|CCBL1_uc004bwg.2_Intron|CCBL1_uc010myn.2_Missense_Mutation_p.L91P|CCBL1_uc004bwj.2_Intron|CCBL1_uc011mbl.1_Missense_Mutation_p.L185P|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.L91P	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	91					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	CACATTCCTGAGCGGGTCTAT	0.592000													6	81					0	0	0.021553	0	0	
OLFM1	10439	broad.mit.edu	37	9	138011358	138011358	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:138011358C>T	uc010nar.2	+	6	1108	c.792C>T	c.(790-792)TAC>TAT	p.Y264Y	OLFM1_uc004cfl.3_Silent_p.Y246Y|OLFM1_uc004cfn.3_Silent_p.Y15Y	NM_014279	NP_055094	Q99784	NOE1_HUMAN	olfactomedin related ER localized protein	264	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		AGGTGTGGTACATGGACGGCT	0.532000													21	141					0	0	0.014323	0	0	
MAMDC4	158056	broad.mit.edu	37	9	139748065	139748065	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chr9:139748065C>T	uc004cjs.2	+	4	447	c.397C>T	c.(397-399)CTG>TTG	p.L133L	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	133	Extracellular (Potential).|MAM 1.				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTCGCCAACCCTGCGAGAGGC	0.682000													10	43					0	0	0.008291	0	0	
MSL3	10943	broad.mit.edu	37	X	11779011	11779011	+	Missense_Mutation	SNP	T	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:11779011T>A	uc004cuw.2	+	4	442	c.337T>A	c.(337-339)TTA>ATA	p.L113I	MSL3_uc004cuv.1_Missense_Mutation_p.L113I|MSL3_uc004cux.2_Missense_Mutation_p.L54I|MSL3_uc011mig.1_5'UTR|MSL3_uc011mih.1_Missense_Mutation_p.L101I|MSL3_uc004cuy.2_5'UTR|MSL3_uc011mii.1_5'UTR	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	113					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGACTCTGTCTTAAAAGGCCT	0.418000													3	12					0	0	0.009096	0	0	
KLHL15	80311	broad.mit.edu	37	X	24006435	24006435	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:24006435T>G	uc004dba.3	-	4	1674	c.1418A>C	c.(1417-1419)AAG>ACG	p.K473T		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	473	Kelch 3.									ovary(1)|breast(1)	2						GTAATTCATCTTGCTCTTATT	0.458000													44	147					0	0	0.013114	0	0	
ZFX	7543	broad.mit.edu	37	X	24226360	24226360	+	Silent	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:24226360T>G	uc004dbf.2	+	7	1224	c.966T>G	c.(964-966)GTT>GTG	p.V322V	ZFX_uc004dbd.1_Silent_p.V322V|ZFX_uc010nfx.1_Silent_p.V93V|ZFX_uc004dbe.2_Silent_p.V322V|ZFX_uc011mjv.1_Silent_p.V361V|ZFX_uc010nfy.1_Intron|ZFX_uc010nfz.2_Silent_p.V25V	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						CTGACGAAGTTTATATGGAAG	0.443000													4	69					0	0	0.014758	0	0	
IL1RAPL1	11141	broad.mit.edu	37	X	29301159	29301159	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:29301159A>C	uc004dby.2	+	3	695	c.187A>C	c.(187-189)AAT>CAT	p.N63H		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	63	Ig-like C2-type 1.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TATCAGAACAAATTACTCCCT	0.418000													22	81					0	0	0.014323	0	0	
KDM6A	7403	broad.mit.edu	37	X	44928861	44928861	+	Missense_Mutation	SNP	C	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:44928861C>G	uc004dge.3	+	17	2336	c.1961C>G	c.(1960-1962)CCT>CGT	p.P654R	KDM6A_uc010nhk.2_Missense_Mutation_p.P620R|KDM6A_uc011mkz.1_Missense_Mutation_p.P706R|KDM6A_uc011mla.1_Missense_Mutation_p.P609R|KDM6A_uc011mlb.1_Missense_Mutation_p.P661R|KDM6A_uc011mlc.1_Missense_Mutation_p.P358R|KDM6A_uc011mld.1_Missense_Mutation_p.P293R	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	654					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TCGGCAGGTCCTAATGGTGAA	0.443000			D|N|F|S		renal|oesophageal SCC|MM								8	18					0	0	0.013537	0	0	
ITIH5L	347365	broad.mit.edu	37	X	54785174	54785174	+	Missense_Mutation	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:54785174T>C	uc004dtj.2	-	8	1363	c.1333A>G	c.(1333-1335)AAC>GAC	p.N445D		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	445	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						ATTCCCCGGTTTTCCAGGGAC	0.582000													3	19					0	0	0.004672	0	0	
TRO	7216	broad.mit.edu	37	X	54955296	54955296	+	Missense_Mutation	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:54955296A>C	uc004dtq.2	+	12	2246	c.2139A>C	c.(2137-2139)GAA>GAC	p.E713D	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.E244D|TRO_uc004dtw.2_Missense_Mutation_p.E316D|TRO_uc004dtx.2_Missense_Mutation_p.E96D	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	713					embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GAGCCCAAGAAAATGCAGATG	0.493000													6	16					0	0	0.021553	0	0	
ZC4H2	55906	broad.mit.edu	37	X	64140008	64140008	+	Silent	SNP	C	T	T			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:64140008C>T	uc004dvu.2	-	3	439	c.351G>A	c.(349-351)CTG>CTA	p.L117L	ZC4H2_uc004dvv.2_Silent_p.L94L|ZC4H2_uc011mov.1_Silent_p.L94L|ZC4H2_uc011mow.1_Silent_p.L117L|ZC4H2_uc004dvw.1_Silent_p.L117L	NM_018684	NP_061154	Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	117							metal ion binding|protein binding			ovary(1)	1						GGAGCCTCTGCAGGCCCAGAG	0.522000													15	56					0	0	0.020292	0	0	
RLIM	51132	broad.mit.edu	37	X	73812787	73812787	+	Silent	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:73812787A>G	uc004ebu.2	-	5	653	c.363T>C	c.(361-363)TCT>TCC	p.S121S	RLIM_uc004ebw.2_Silent_p.S121S	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	121					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CTGCTCTCCAAGATTGGTTTC	0.393000													17	195					0	0	0.007413	0	0	
KLHL4	56062	broad.mit.edu	37	X	86773290	86773290	+	Missense_Mutation	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:86773290G>A	uc004efb.2	+	1	576	c.394G>A	c.(394-396)GAT>AAT	p.D132N	KLHL4_uc004efa.2_Missense_Mutation_p.D132N	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	132						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GATGATGGCTGATGACAATAT	0.363000													11	73					0	0	0.024245	0	0	
TCEAL5	340543	broad.mit.edu	37	X	102529262	102529262	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:102529262T>G	uc004ejz.1	-	3	525	c.230A>C	c.(229-231)AAG>ACG	p.K77T		NM_001012979	NP_001012997	Q5H9L2	TCAL5_HUMAN	transcription elongation factor A (SII)-like 5	77	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(1)|breast(1)	2						ACCTTCAGACTTGCCCTGCTT	0.418000													3	98					0	0	0.004672	0	0	
CXorf57	55086	broad.mit.edu	37	X	105855681	105855681	+	Missense_Mutation	SNP	A	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:105855681A>G	uc004emi.3	+	1	522	c.371A>G	c.(370-372)AAA>AGA	p.K124R	CXorf57_uc004emj.3_Missense_Mutation_p.K124R|CXorf57_uc004emh.2_Missense_Mutation_p.K124R	NM_018015	NP_060485	Q6NSI4	CX057_HUMAN	hypothetical protein LOC55086	124										ovary(1)|lung(1)|breast(1)	3						AATATTCTTAAAGTTGGCATT	0.453000													8	213					0	0	0.003080	0	0	
KIAA1210	57481	broad.mit.edu	37	X	118221482	118221482	+	Silent	SNP	T	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:118221482T>C	uc004era.3	-	11	3711	c.3711A>G	c.(3709-3711)CAA>CAG	p.Q1237Q		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	1237										ovary(4)|skin(1)	5						CTGAGAAAACTTGGTGCTTGA	0.478000													7	28					0	0	0.003080	0	0	
THOC2	57187	broad.mit.edu	37	X	122830587	122830587	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:122830587T>G	uc004etu.2	-	6	483	c.451A>C	c.(451-453)ATC>CTC	p.I151L	THOC2_uc011muh.1_Missense_Mutation_p.I72L|THOC2_uc011mui.1_Missense_Mutation_p.I36L	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	151					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TTTGTCTTGATTTTAACTGAC	0.358000													12	98					0	0	0.010729	0	0	
USP26	83844	broad.mit.edu	37	X	132162027	132162027	+	Silent	SNP	A	C	C			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:132162027A>C	uc010nrm.1	-	6	692	c.222T>G	c.(220-222)ACT>ACG	p.T74T	USP26_uc011mvf.1_Silent_p.T74T	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	74					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					TATTTTGTAAAGTTAAATGCA	0.328000													19	71					0	0	0.012319	0	0	
ARHGEF6	9459	broad.mit.edu	37	X	135862980	135862980	+	Missense_Mutation	SNP	T	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:135862980T>G	uc004fab.2	-	1	524	c.62A>C	c.(61-63)AAA>ACA	p.K21T		NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	21	CH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					GATGGTCTTTTTAGGGGACTC	0.458000													17	155					0	0	0.004990	0	0	
SPANXN2	494119	broad.mit.edu	37	X	142795330	142795330	+	Silent	SNP	G	A	A			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:142795330G>A	uc004fbz.2	-	2	1102	c.348C>T	c.(346-348)GAC>GAT	p.D116D		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	116										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCAGATGAGTCCAGGTCTT	0.522000													13	408					0	0	0.024334	0	0	
FGD1	2245	broad.mit.edu	37	X	54472631	54472632	+	Frame_Shift_Ins	INS	-	G	G			TCGA-CD-5801-01A-11D-1600-08	TCGA-CD-5801-10A-01D-1600-08									Somatic	Phase_I	Capture				Illumina GAIIx	6097aab1-54ce-4157-85fd-3543fe555da7	797549d4-068f-4f51-9d73-4f187492e0bf	g.chrX:54472631_54472632insG	uc004dtg.2	-	18	3530_3531	c.2796_2797insC	c.(2794-2799)TCTGAGfs	p.S932fs		NM_004463	NP_004454	P98174	FGD1_HUMAN	faciogenital dysplasia protein	932_933					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TCCCTGTCCTCAGACAGTGTGG	0.644													10	23	---	---	---	---						.
