Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SEZ6L	23544	broad.mit.edu	37	22	26695087	26695087	+	Missense_Mutation	SNP	A	C	C			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr22:26695087A>C	uc003acb.3	+	4	1496	c.1300A>C	c.(1300-1302)Atc>Ctc	p.I434L	SEZ6L_uc003acd.3_Missense_Mutation_p.I434L|SEZ6L_uc011akd.2_Missense_Mutation_p.I434L|SEZ6L_uc003ace.3_Missense_Mutation_p.I434L|SEZ6L_uc011akc.2_Missense_Mutation_p.I434L|SEZ6L_uc003acc.3_Missense_Mutation_p.I434L|SEZ6L_uc003acf.1_Missense_Mutation_p.I207L|SEZ6L_uc010gvc.1_Missense_Mutation_p.I207L	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	Homo sapiens seizure related 6 homolog (mouse)-like (SEZ6L), transcript variant 1, mRNA.	434	Sushi 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						GCTGACATGCATCAATGCCTC	0.597000														25			7		0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40342768	40342768	+	Splice_Site	SNP	G	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr2:40342768G>T	uc002rrx.3	-	10	2570	c.2546_splice	c.e10-1	p.D849_splice	LOC100128590_uc002rrw.3_Intron|SLC8A1_uc002rry.3_Splice_Site_p.D844_splice|SLC8A1_uc002rsb.2_Splice_Site_p.D841_splice|SLC8A1_uc002rrz.3_Splice_Site_p.D836_splice|SLC8A1_uc002rsa.3_Splice_Site_p.D813_splice|SLC8A1_uc002rsd.4_Splice_Site_p.D813_splice	NM_021097	NP_066920	P32418	NAC1_HUMAN	Homo sapiens solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1), transcript variant A, mRNA.	849					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGGCAAATGTGTCTGCAGAGG	0.507000														49			16		2.89027e-11	3.07091e-11	1	1	0
ITGAL	3683	broad.mit.edu	37	16	30510706	30510706	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr16:30510706C>T	uc002dyi.4	+	16	2217	c.2041C>T	c.(2041-2043)Cgg>Tgg	p.R681W	ITGAL_uc002dyj.4_Missense_Mutation_p.R598W|ITGAL_uc010vev.2_Missense_Mutation_p.R77W	NM_002209	NP_002200	P20701	ITAL_HUMAN	Homo sapiens integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (ITGAL), transcript variant 1, mRNA.	681					T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	cell adhesion molecule binding|receptor activity	p.R681Q(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GGATGGCCACCGGACCAGAAG	0.537000														185			57		0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61941834	61941834	+	Silent	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr20:61941834C>T	uc011aau.2	+	10	1465	c.1365C>T	c.(1363-1365)ggC>ggT	p.G455G	COL20A1_uc011aav.2_Silent_p.G276G	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	Homo sapiens collagen, type XX, alpha 1 (COL20A1), mRNA.	455	Fibronectin type-III 2.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GCGGGGTTGGCGAAGGCCTGC	0.687000														12			3		0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123185435	123185435	+	Silent	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr4:123185435C>T	uc003ieh.3	+	42	7215	c.7170C>T	c.(7168-7170)ccC>ccT	p.P2390P	KIAA1109_uc003iel.1_Silent_p.P325P|KIAA1109_uc003iek.2_Silent_p.P1009P	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	Homo sapiens KIAA1109 (KIAA1109), mRNA.	2390					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CAACAATACCCTCAGCCTCAG	0.398000														64			27		0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128494189	128494189	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr7:128494189G>A	uc003vnz.4	+	39	6855	c.6646G>A	c.(6646-6648)Gac>Aac	p.D2216N	FLNC_uc003voa.4_Missense_Mutation_p.D2183N	NM_001458	NP_001449	Q14315	FLNC_HUMAN	Homo sapiens filamin C, gamma (FLNC), transcript variant 1, mRNA.	2216	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GGTCGGCGGGGACCCCTTCCC	0.697000														38			30		0	0	1	0	0
ETS1	2113	broad.mit.edu	37	11	128332410	128332410	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr11:128332410C>T	uc010sbs.1	-	7	1488	c.1172G>A	c.(1171-1173)cGt>cAt	p.R391H	ETS1_uc001qej.2_Missense_Mutation_p.R435H|ETS1_uc009zch.2_Missense_Mutation_p.R175H|ETS1_uc009zcg.2_3'UTR	NM_005238	NP_005229	P14921	ETS1_HUMAN	Homo sapiens v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) (ETS1), transcript variant 2, mRNA.	391					PML body organization|cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GCGTAGGCCACGGCTCAGTTT	0.458000														42			21		0	0	1	0	0
CAPS	828	broad.mit.edu	37	19	5915243	5915243	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr19:5915243G>A	uc002mdt.3	+	4	630	c.480G>A	c.(478-480)gcG>gcA	p.A160A	CAPS_uc002mdu.3_Silent_p.A133A	NM_004058	NP_004049	Q13938	CAYP1_HUMAN	Homo sapiens calcyphosine (CAPS), transcript variant 1, mRNA.	160	EF-hand 4.				intracellular signal transduction	cytoplasm	calcium ion binding			cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	4						TCACACTGGCGGAATTCCAGG	0.667000														37			18		0	0	1	0	0
GPR135	64582	broad.mit.edu	37	14	59930877	59930877	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr14:59930877G>A	uc010apj.3	-	0	1183	c.1068C>T	c.(1066-1068)gcC>gcT	p.A356A	GPR135_uc001xed.2_Non-coding_Transcript	NM_022571	NP_072093	Q8IZ08	GP135_HUMAN	Homo sapiens G protein-coupled receptor 135 (GPR135), mRNA.	356						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.134)		GGGCCTGCCGGGCGGCGGCCA	0.667000														16			5		0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57553705	57553705	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr12:57553705G>A	uc001snd.3	+	11	2362	c.1896G>A	c.(1894-1896)ctG>ctA	p.L632L		NM_002332	NP_002323	Q07954	LRP1_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 1 (LRP1), mRNA.	632					aorta morphogenesis|apoptotic cell clearance|negative regulation of Wnt receptor signaling pathway|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGGCCAGGCTGGAGAAAGCTG	0.567000														130			3		0	0	1	0	0
GPT	2875	broad.mit.edu	37	8	145730778	145730778	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr8:145730778G>A	uc003zdh.4	+	4	868	c.645G>A	c.(643-645)gcG>gcA	p.A215A	GPT_uc011llj.1_Silent_p.A215A	NM_005309	NP_005300	P24298	ALAT1_HUMAN	Homo sapiens glutamic-pyruvate transaminase (alanine aminotransferase) (GPT), mRNA.	215					gluconeogenesis	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)		L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GTGCCTGGGCGCTGGACGTGG	0.672000														39			3		0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116045883	116045883	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr10:116045883G>A	uc001lbl.1	+	10	1504	c.1183G>A	c.(1183-1185)Gtg>Atg	p.V395M	VWA2_uc001lbk.1_Missense_Mutation_p.V395M|VWA2_uc009xyf.1_Missense_Mutation_p.V91M	NM_198496	NP_940898	Q5GFL6	VWA2_HUMAN	Homo sapiens von Willebrand factor A domain containing 2 (VWA2), mRNA.	395	VWFA 2.					extracellular region		p.A394V(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GCTGGTGGCGGTGCCTGTGGG	0.662000														177			4		0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31779208	31779208	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr6:31779208G>A	uc003nxh.3	-	1	725	c.542C>T	c.(541-543)gCt>gTt	p.A181V	HSPA1L_uc010jte.3_Missense_Mutation_p.A181V|HSPA1L_uc021yuz.1_Missense_Mutation_p.A181V	NM_005527	NP_005518	P34931	HS71L_HUMAN	Homo sapiens heat shock 70kDa protein 1-like (HSPA1L), mRNA.	181					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						GGCAATGGCAGCAGCCGTGGG	0.458000														72			3		0	0	1	0	0
MEF2B	100271849	broad.mit.edu	37	19	19258532	19258532	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr19:19258532G>A	uc002nlp.2	-	5	1095	c.368C>T	c.(367-369)cCg>cTg	p.P123L	MEF2B_uc002nll.2_Missense_Mutation_p.P123L|MEF2B_uc010xqo.1_Missense_Mutation_p.P123L|MEF2B_uc010xqp.1_Missense_Mutation_p.P123L|MEF2B_uc002nlo.2_Missense_Mutation_p.P123L|MEF2B_uc002nlk.2_Missense_Mutation_p.P126L	NM_005919	NP_005910			Homo sapiens MEF2BNB-MEF2B readthrough (MEF2BNB-MEF2B), transcript variant 1, mRNA.											breast(1)|haematopoietic_and_lymphoid_tissue(21)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			GGGCAAGGCCGGATCACCCCC	0.627000														114			3		0	0	1	0	0
C3orf43	255798	broad.mit.edu	37	3	196235046	196235046	+	Silent	SNP	T	C	C			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr3:196235046T>C	uc003fws.3	-	2	514	c.357A>G	c.(355-357)agA>agG	p.R119R	C3orf43_uc003fwr.3_Silent_p.R111R	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	Homo sapiens chromosome 3 open reading frame 43 (C3orf43), mRNA.	119						integral to membrane				NS(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)	8	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		CCCATACAACTCTAACGCGCT	0.483000														73			25		0	0	1	0	0
TMEM50B	757	broad.mit.edu	37	21	34839360	34839360	+	RNA	SNP	C	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr21:34839360C>A	uc002yrs.2	-	2		c.382G>T			TMEM50B_uc010gmb.2_Non-coding_Transcript	NM_006134		P56557	TM50B_HUMAN	Homo sapiens transmembrane protein 50B (TMEM50B), transcript variant 1, mRNA.							endoplasmic reticulum|integral to membrane|plasma membrane				breast(1)|kidney(1)|ovary(1)|skin(1)	4						GTGTGAAAGGCATGGTTCAAC	0.368000														101			3		0.014758	0.0152052	1	1	0
ELFN2	114794	broad.mit.edu	37	22	37769205	37769205	+	Silent	SNP	G	A	A	rs148494870	by1000genomes	TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr22:37769205G>A	uc003asq.4	-	2	3156	c.2370C>T	c.(2368-2370)caC>caT	p.H790H	ELFN2_uc021wph.1_Silent_p.H790H	NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	Homo sapiens extracellular leucine-rich repeat and fibronectin type III domain containing 2 (ELFN2), mRNA.	790						cell surface|integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	35	Melanoma(58;0.0574)					TGCGCAGGGCGTGACCGGCGG	0.627000														82			44		0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88679156	88679156	+	Missense_Mutation	SNP	T	G	G			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr15:88679156T>G	uc002bme.2	-	8	1187	c.881A>C	c.(880-882)aAt>aCt	p.N294T	NTRK3_uc002bmh.2_Missense_Mutation_p.N294T|NTRK3_uc002bmf.2_Missense_Mutation_p.N294T|NTRK3_uc021sua.1_Missense_Mutation_p.N294T|NTRK3_uc010upl.1_Missense_Mutation_p.N196T|NTRK3_uc010bnh.1_Missense_Mutation_p.N294T|NTRK3_uc002bmg.3_Missense_Mutation_p.N294T	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	Homo sapiens neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant 1, mRNA.	294	Ig-like C2-type 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AACACTGGCATTGCTCATGCC	0.542000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)				63			33		0	0	1	0	0
PALB2	79728	broad.mit.edu	37	16	23646583	23646583	+	Silent	SNP	G	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr16:23646583G>T	uc002dlx.1	-	3	1484	c.1284C>A	c.(1282-1284)gtC>gtA	p.V428V		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	Homo sapiens partner and localizer of BRCA2 (PALB2), mRNA.	428					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		GACTCTGAATGACAGCCTCCA	0.393000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks						85			3		1	1	1	1	0
ITGA2	3673	broad.mit.edu	37	5	52360756	52360756	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr5:52360756G>A	uc003joy.3	+	13	1760	c.1617G>A	c.(1615-1617)caG>caA	p.Q539Q	ITGA2_uc011cqa.2_Non-coding_Transcript|ITGA2_uc011cqb.2_Non-coding_Transcript|ITGA2_uc011cqc.2_Silent_p.Q463Q|ITGA2_uc011cqd.2_Non-coding_Transcript|ITGA2_uc011cqe.2_Non-coding_Transcript	NM_002203	NP_002194	P17301	ITA2_HUMAN	Homo sapiens integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2), mRNA.	539					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity	p.Q539Q(3)|p.G538C(1)		breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TTTTGGGTCAGCACCAATTTC	0.428000														104			3		0	0	1	0	0
ELMO3	79767	broad.mit.edu	37	16	67237636	67237636	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr16:67237636G>A	uc002esa.3	+	19	2221	c.2178G>A	c.(2176-2178)ctG>ctA	p.L726L	ELMO3_uc002esb.3_Silent_p.L709L|ELMO3_uc002esc.3_Silent_p.L560L|MIR328_uc010vjf.1_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	Homo sapiens engulfment and cell motility 3 (ELMO3), mRNA.	673					apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding			cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		AGACACGGCTGGACCTGGAGC	0.672000														139			4		0	0	1	0	0
ITGA6	3655	broad.mit.edu	37	2	173292654	173292654	+	Silent	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr2:173292654C>T	uc002uhp.1	+	0	341	c.138C>T	c.(136-138)ttC>ttT	p.F46F	ITGA6_uc010fqk.1_Intron|ITGA6_uc010zdy.1_Intron|ITGA6_uc002uho.1_Silent_p.F46F	NM_001079818	NP_001073286	P23229	ITA6_HUMAN	Homo sapiens integrin, alpha 6 (ITGA6), transcript variant 1, mRNA.	46					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			TCTTCGGCTTCTCGCTGGCCA	0.672000														39			19		0	0	1	0	0
GALNT4	8693	broad.mit.edu	37	12	89864264	89864264	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr12:89864264G>A	uc001tbc.3	-	6	1051	c.684C>T	c.(682-684)agC>agT	p.S228S	GALNT4_uc001tba.3_Silent_p.S186S|GALNT4_uc001tbb.3_Silent_p.S98S|GALNT4_uc010sun.2_Non-coding_Transcript|GALNT4_uc009zsp.3_Non-coding_Transcript|GALNT4_uc009zsq.3_Intron	NM_172240	NP_001186706	Q8N4A0	GALT4_HUMAN	Homo sapiens POC1 centriolar protein homolog B (Chlamydomonas) (POC1B), transcript variant 1, mRNA.	0	Catalytic subdomain A.				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(4)|kidney(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)	14						TAACTCCACCGCTGTGAACTG	0.388000														68			3		0	0	1	0	0
abParts	0	broad.mit.edu	37	22	22453352	22453352	+	RNA	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr22:22453352C>T	uc021wml.1	+	6		c.473C>T								Parts of antibodies, mostly variable regions.																		CAGGAGCCATCGTTCTCAGTG	0.522000														46			22		0	0	1	0	0
STOML2	30968	broad.mit.edu	37	9	35102741	35102741	+	Missense_Mutation	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr9:35102741G>A	uc003zwi.3	-	1	188	c.125C>T	c.(124-126)cCg>cTg	p.P42L	STOML2_uc011lou.2_Missense_Mutation_p.P42L	NM_013442	NP_038470	Q9UJZ1	STML2_HUMAN	Homo sapiens stomatin (EPB72)-like 2 (STOML2), mRNA.	42						cytoskeleton	receptor binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|prostate(1)	16			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTCCTGCTGCGGCACGAACAG	0.642000														111			52		0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95735751	95735751	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr5:95735751C>T	uc003kls.2	-	9	1575	c.1336G>A	c.(1336-1338)Gcc>Acc	p.A446T	PCSK1_uc010jbi.2_Missense_Mutation_p.A136T|PCSK1_uc021ybq.1_Missense_Mutation_p.A399T	NM_000439	NP_000430	P29120	NEC1_HUMAN	Homo sapiens proprotein convertase subtilisin/kexin type 1 (PCSK1), transcript variant 1, mRNA.	446					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGAGCTTTGGCATTTAGCAAG	0.493000														49			47		0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380580	147380580	+	Silent	SNP	C	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr1:147380580C>A	uc021ovm.1	+	0	498	c.498C>A	c.(496-498)atC>atA	p.I166I	GJA8_uc001epu.2_Silent_p.I166I	NM_005267	NP_005258	P48165	CXA8_HUMAN	Homo sapiens gap junction protein, alpha 8, 50kDa (GJA8), mRNA.	166					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					TGGGCTTCATCGTGGGCCACT	0.607000														144			101		9.33504e-39	1.05797e-38	1	1	0
AP5Z1	9907	broad.mit.edu	37	7	4830986	4830986	+	Silent	SNP	G	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr7:4830986G>T	uc003sne.3	+	16	2479	c.2394G>T	c.(2392-2394)gtG>gtT	p.V798V	AP5Z1_uc010ksp.3_Non-coding_Transcript|AP5Z1_uc003snf.3_Silent_p.V275V|MIR4656_uc021zzb.1_5'Flank	NM_014855	NP_055670	O43299	K0415_HUMAN	Homo sapiens KIAA0415 (KIAA0415), mRNA.	798					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										GCCGGCTGGTGGAGAGGGAGG	0.667000														28			18		1.02788e-11	1.12736e-11	1	1	0
WDR66	144406	broad.mit.edu	37	12	122359381	122359381	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr12:122359381C>T	uc009zxk.3	+	1	329	c.170C>T	c.(169-171)aCg>aTg	p.T57M	WDR66_uc021rfh.1_Missense_Mutation_p.T57M	NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	Homo sapiens WD repeat domain 66 (WDR66), transcript variant 1, mRNA.	57	Glu-rich.						calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		gagaggaaaacgggcgaggag	0.468000														17			7		0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47532397	47532397	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr21:47532397C>T	uc002zia.1	+	2	702	c.620C>T	c.(619-621)aCg>aTg	p.T207M	COL6A2_uc002zhz.1_Missense_Mutation_p.T207M|COL6A2_uc002zhy.1_Missense_Mutation_p.T207M	NM_001849	NP_001840	P12110	CO6A2_HUMAN	Homo sapiens collagen, type VI, alpha 2 (COL6A2), transcript variant 2C2, mRNA.	207	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		ATCGCCAGCACGCCGCACGAG	0.662000														26			13		0	0	1	0	0
EFNB1	1947	broad.mit.edu	37	X	68060182	68060182	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chrX:68060182G>A	uc004dxe.2	+	4	1506	c.726G>A	c.(724-726)gcG>gcA	p.A242A	EFNB1_uc004dxd.4_Silent_p.A242A	NM_004429	NP_004420	P98172	EFNB1_HUMAN	Homo sapiens ephrin-B1 (EFNB1), mRNA.	242					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding	p.A242T(1)		breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						CATTGTTCGCGGCTGTCGGTG	0.587000														36			9		0	0	1	0	0
SLC25A33	84275	broad.mit.edu	37	1	9642501	9642501	+	Missense_Mutation	SNP	C	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr1:9642501C>T	uc001apw.3	+	6	1131	c.908C>T	c.(907-909)gCc>gTc	p.A303V		NM_032315	NP_115691	Q9BSK2	S2533_HUMAN	Homo sapiens solute carrier family 25, member 33 (SLC25A33), nuclear gene encoding mitochondrial protein, mRNA.	303					transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|kidney(1)|lung(4)|prostate(1)|skin(1)	9	all_lung(157;0.246)	all_epithelial(116;1.16e-18)|all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Breast(348;0.00191)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.44e-05)|Kidney(185;0.000262)|KIRC - Kidney renal clear cell carcinoma(229;0.000957)|BRCA - Breast invasive adenocarcinoma(304;0.0019)|STAD - Stomach adenocarcinoma(132;0.00355)|READ - Rectum adenocarcinoma(331;0.0419)		CCAAATACTGCCATTGTGTTG	0.453000														20			7		0	0	1	0	0
ZNF414	84330	broad.mit.edu	37	19	8576745	8576745	+	Silent	SNP	G	A	A			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr19:8576745G>A	uc002mke.4	-	4	748	c.630C>T	c.(628-630)ccC>ccT	p.P210P	ZNF414_uc010dwf.3_Silent_p.P199P|ZNF414_uc002mkf.3_Silent_p.P210P	NM_001146175	NP_001139647	Q96IQ9	ZN414_HUMAN	Homo sapiens zinc finger protein 414 (ZNF414), transcript variant 1, mRNA.	210					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(2)	2						CCAGGGCCGGGGGTGGCGGCG	0.726000														5			3		0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74274412	74274412	+	Missense_Mutation	SNP	A	T	T			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr4:74274412A>T	uc003hgs.4	+	3	445	c.372A>T	c.(370-372)gaA>gaT	p.E124D	ALB_uc011cbe.2_Intron|ALB_uc003hgw.4_Intron|ALB_uc011cbf.2_Missense_Mutation_p.E14D	NM_000477	NP_000468	P02768	ALBU_HUMAN	Homo sapiens albumin (ALB), mRNA.	124	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	DNA binding|antioxidant activity|chaperone binding|copper ion binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AGAGAAATGAATGCTTCTTGC	0.433000														35			14		0	0	1	0	0
KCNK12	56660	broad.mit.edu	37	2	47797086	47797086	+	Frame_Shift_Del	DEL	T	-	-			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr2:47797086delT	uc002rwb.3	-	0	385	c.385delA	c.(385-387)accfs	p.T129fs	MSH2_uc002rvz.3_Intron	NM_022055	NP_071338	Q9HB15	KCNKC_HUMAN	Homo sapiens potassium channel, subfamily K, member 12 (KCNK12), mRNA.	129						integral to membrane	potassium channel activity|voltage-gated ion channel activity	p.0?(2)|p.?(1)		NS(1)|endometrium(1)|lung(3)|ovary(1)	6		all_hematologic(82;0.0495)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TCACCTATGGTTGACACCACG	0.721													---	4	---	---	2	---					
KDM3B	51780	broad.mit.edu	37	5	137727661	137727661	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EL-A3T9-01A-21D-A22D-08	TCGA-EL-A3T9-11A-11D-A22D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d692ecd0-2433-426b-9af2-a30c44a80f7c	60ecca33-9f6a-4c77-a862-6f3d723029c9	g.chr5:137727661delG	uc003lcy.1	+	7	2540	c.2340delG	c.(2338-2340)ccgfs	p.P780fs	KDM3B_uc010jew.1_Frame_Shift_Del_p.P436fs|KDM3B_uc011cys.1_Intron	NM_016604	NP_057688	Q7LBC6	KDM3B_HUMAN	Homo sapiens lysine (K)-specific demethylase 3B (KDM3B), mRNA.	780					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TGTCCTCCCCGGCAGATTTTT	0.532													---	270	---	---	193	---					
