Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RCOR1	23186	broad.mit.edu	37	14	103148316	103148316	+	Splice_Site	SNP	G	T	T			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr14:103148316G>T	uc001ymb.3	+	3	673	c.436_splice	c.e3+1	p.L146_splice		NM_015156	NP_055971	Q9UKL0	RCOR1_HUMAN	Homo sapiens REST corepressor 1 (RCOR1), mRNA.	146	ELM2.|Interaction with HDAC1.				blood coagulation|histone H4 deacetylation|interspecies interaction between organisms	transcriptional repressor complex	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|protein binding|transcription regulatory region DNA binding	p.?(1)		NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	12						GAAGCAAAGTGTAAGTCTTGG	0.378000														54			3		1	1	1	1	0
MOAP1	64112	broad.mit.edu	37	14	93650551	93650551	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr14:93650551T>C	uc021saw.1	-	0	37	c.37A>G	c.(37-39)Atg>Gtg	p.M13V	MOAP1_uc001ybj.3_Missense_Mutation_p.M13V|C14orf109_uc001ybk.4_5'Flank|C14orf109_uc010auo.3_5'Flank|C14orf109_uc021sax.1_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	Homo sapiens modulator of apoptosis 1 (MOAP1), mRNA.	13					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		ttcatgtccatccccctgcac	0.507000														149			3		0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60695172	60695172	+	Silent	SNP	C	G	G			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr11:60695172C>G	uc001nqi.3	+	2	568	c.375C>G	c.(373-375)gcC>gcG	p.A125A	TMEM132A_uc001nqj.3_Silent_p.A125A|TMEM132A_uc001nqk.3_Silent_p.A138A|TMEM132A_uc001nql.1_Silent_p.A138A	NM_017870	NP_060340	Q24JP5	T132A_HUMAN	Homo sapiens transmembrane protein 132A (TMEM132A), transcript variant 1, mRNA.	125						Golgi membrane|endoplasmic reticulum membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						ACGTGCGGGCCGTTTCAGTGG	0.632000														132			13		0	0	1	0	0
FAM123C	205147	broad.mit.edu	37	2	131521451	131521451	+	Silent	SNP	G	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr2:131521451G>A	uc021voy.1	+	0	1806	c.1806G>A	c.(1804-1806)gaG>gaA	p.E602E	FAM123C_uc002trw.2_Silent_p.E602E|FAM123C_uc010fmv.2_Silent_p.E602E|FAM123C_uc010fms.1_Silent_p.E602E|FAM123C_uc010fmt.1_Silent_p.E602E|FAM123C_uc010fmu.1_Silent_p.E602E	NM_152698	NP_689911	Q8N944	F123C_HUMAN	Homo sapiens family with sequence similarity 123C (FAM123C), transcript variant 1, mRNA.	602										breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(43)|ovary(2)|pancreas(4)|prostate(3)|skin(8)	73	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		CCTCTCGAGAGGAAGAGACAC	0.592000														86			3		0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133065566	133065566	+	Missense_Mutation	SNP	A	G	G			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr6:133065566A>G	uc003qdt.3	-	6	1447	c.1436T>C	c.(1435-1437)cTc>cCc	p.L479P	VNN2_uc003qds.3_Missense_Mutation_p.L188P|VNN2_uc010kgb.3_Missense_Mutation_p.L258P|VNN2_uc003qdv.3_Missense_Mutation_p.L426P	NM_004665	NP_004656	O95498	VNN2_HUMAN	Homo sapiens vanin 2 (VNN2), transcript variant 1, mRNA.	479					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CCTCCCAAAGAGTGACACTGT	0.403000														51			50		0	0	1	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151196719	151196719	+	Splice_Site	SNP	A	G	G			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr1:151196719A>G	uc001exj.3	+	2	538	c.86_splice	c.e2-2	p.A29_splice	PIP5K1A_uc021oyo.1_Splice_Site_p.A29_splice|PIP5K1A_uc001exi.3_Intron|PIP5K1A_uc010pcu.2_Splice_Site_p.A29_splice|PIP5K1A_uc001exk.3_Intron	NM_001135638	NP_001129110	Q99755	PI51A_HUMAN	Homo sapiens phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (PIP5K1A), transcript variant 1, mRNA.	29					phospholipid biosynthetic process|signal transduction	Golgi stack|endomembrane system|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTTCCCCCCTAGCAGCATCTG	0.383000														126			3		0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54805631	54805631	+	Nonsense_Mutation	SNP	C	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr6:54805631C>A	uc003pck.3	+	4	1978	c.1862C>A	c.(1861-1863)tCa>tAa	p.S621*		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	Homo sapiens family with sequence similarity 83, member B (FAM83B), mRNA.	621										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GAAAACCACTCAGTAGCCTTA	0.398000														54			3		0.115264	0.120067	1	1	0
TAS2R20	259295	broad.mit.edu	37	12	11149659	11149659	+	Silent	SNP	T	C	C			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr12:11149659T>C	uc001qzm.2	-	0	816	c.816A>G	c.(814-816)ccA>ccG	p.P272P	PRH1_uc001qzb.4_Intron|TAS2R14_uc021qve.1_Intron|PRH1_uc021qvg.1_Intron|PRB4_uc001qzf.1_Intron|TAS2R14_uc001qzj.3_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	Homo sapiens taste receptor, type 2, member 20 (TAS2R20), mRNA.	272					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13						AGTGGAATGATGGATATATGA	0.393000														93			7		0	0	1	0	0
POGZ	23126	broad.mit.edu	37	1	151377730	151377730	+	Missense_Mutation	SNP	T	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr1:151377730T>A	uc001eyd.2	-	18	4096	c.3781A>T	c.(3781-3783)Att>Ttt	p.I1261F	POGZ_uc021oyq.1_Missense_Mutation_p.I1208F|POGZ_uc010pdb.2_Missense_Mutation_p.I1252F|POGZ_uc010pdc.2_Missense_Mutation_p.I1199F|POGZ_uc009wmv.2_Missense_Mutation_p.I1166F|POGZ_uc001eyf.2_Missense_Mutation_p.I1217F|POGZ_uc010pdd.2_Missense_Mutation_p.I752F	NM_015100	NP_055915	Q7Z3K3	POGZ_HUMAN	Homo sapiens pogo transposable element with ZNF domain (POGZ), transcript variant 1, mRNA.	1261	DDE.				cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AATGGCTGAATTTTGGAGCTA	0.468000														192			8		0	0	1	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155932417	155932417	+	Silent	SNP	G	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr1:155932417G>A	uc001fmu.2	-	12	1455	c.1200C>T	c.(1198-1200)taC>taT	p.Y400Y	ARHGEF2_uc001fmr.2_Silent_p.Y328Y|ARHGEF2_uc001fms.2_Silent_p.Y355Y|ARHGEF2_uc001fmt.2_Silent_p.Y356Y|ARHGEF2_uc010pgt.1_Silent_p.Y329Y|ARHGEF2_uc010pgu.1_Silent_p.Y401Y	NM_004723	NP_004714	Q92974	ARHG2_HUMAN	Homo sapiens Rho/Rac guanine nucleotide exchange factor (GEF) 2 (ARHGEF2), transcript variant 3, mRNA.	356	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of Rho protein signal transduction|regulation of cell proliferation|small GTPase mediated signal transduction	Golgi apparatus|cytosol|microtubule|ruffle membrane|spindle|tight junction	Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|microtubule binding|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGTCTCGGGCGTACAGCTCCT	0.557000														68			3		0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	rs121913377		TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome					70			54		0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33468782	33468782	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr9:33468782T>C	uc003zsz.3	-	7	1216	c.1115A>G	c.(1114-1116)tAc>tGc	p.Y372C	NOL6_uc003zta.3_Missense_Mutation_p.Y372C|NOL6_uc010mjv.3_Missense_Mutation_p.Y372C|NOL6_uc011lob.2_Missense_Mutation_p.Y312C|NOL6_uc003ztb.1_Missense_Mutation_p.Y372C	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	Homo sapiens nucleolar protein family 6 (RNA-associated) (NOL6), transcript variant alpha, mRNA.	372					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CAGGACCTGGTAGCCACTCAT	0.547000														314			4		0	0	1	0	0
WIPF1	7456	broad.mit.edu	37	2	175437077	175437077	+	Silent	SNP	C	T	T			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr2:175437077C>T	uc002uiz.3	-	4	556	c.456G>A	c.(454-456)gtG>gtA	p.V152V	BC046497_uc002uiw.3_Intron|BC046497_uc002uix.1_Intron|WIPF1_uc002uja.3_Silent_p.V152V|WIPF1_uc010fqt.1_Silent_p.V152V|WIPF1_uc002ujc.1_Silent_p.V152V|WIPF1_uc002ujb.2_Silent_p.V152V|WIPF1_uc010zep.1_Silent_p.V152V	NM_003387	NP_003378	O43516	WIPF1_HUMAN	Homo sapiens WAS/WASL interacting protein family, member 1 (WIPF1), transcript variant 1, mRNA.	152					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			NS(1)|breast(1)|endometrium(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)	32						CTGGAGAAGGCACAGGAAACC	0.602000														42			6		0	0	1	0	0
SLC39A7	7922	broad.mit.edu	37	6	33169616	33169616	+	Missense_Mutation	SNP	T	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr6:33169616T>A	uc003odf.3	+	2	623	c.506T>A	c.(505-507)cTt>cAt	p.L169H	RXRB_uc003odb.3_5'Flank|RXRB_uc003odc.3_5'Flank|RXRB_uc011dqr.2_5'Flank|RXRB_uc011dqs.1_5'Flank|RXRB_uc011dqt.1_5'Flank|RXRB_uc011dqu.1_5'Flank|SLC39A7_uc003odg.3_Missense_Mutation_p.L169H|SLC39A7_uc011dqv.2_Missense_Mutation_p.L44H|HSD17B8_uc003odi.1_5'Flank	NM_001077516	NP_008910	Q92504	S39A7_HUMAN	Homo sapiens solute carrier family 39 (zinc transporter), member 7 (SLC39A7), transcript variant 2, mRNA.	169						endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			NS(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						CGCTCTCTACTTCAGATCTTG	0.537000														63			69		0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45533062	45533062	+	Silent	SNP	G	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr3:45533062G>A	uc003cop.1	+	12	1478	c.1293G>A	c.(1291-1293)cgG>cgA	p.R431R	LARS2_uc010hit.1_Silent_p.R388R	NM_015340	NP_056155	Q15031	SYLM_HUMAN	Homo sapiens leucyl-tRNA synthetase 2, mitochondrial (LARS2), nuclear gene encoding mitochondrial protein, mRNA.	431					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	AGAAAGCCCGGGGGAAGAGAG	0.542000														75			3		0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48271724	48271724	+	Silent	SNP	G	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr17:48271724G>A	uc002iqm.3	-	22	1726	c.1600C>T	c.(1600-1602)Ctg>Ttg	p.L534L		NM_000088	NP_000079	P02452	CO1A1_HUMAN	Homo sapiens collagen, type I, alpha 1 (COL1A1), mRNA.	534	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GCACCAGGCAGACCAGCTTCA	0.647000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta							38			41		0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10406153	10406153	+	Missense_Mutation	SNP	C	T	T			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr17:10406153C>T	uc002gmo.3	-	23	3107	c.3013G>A	c.(3013-3015)Gag>Aag	p.E1005K	AK097500_uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	Homo sapiens myosin, heavy chain 1, skeletal muscle, adult (MYH1), mRNA.	1005						muscle myosin complex|myofibril|myosin filament	ATP binding|actin binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TGGTGGGCCTCCTGGAGAGCC	0.498000														127			11		0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41967097	41967097	+	Missense_Mutation	SNP	G	T	T			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr12:41967097G>T	uc010skn.2	+	9	2524	c.2516G>T	c.(2515-2517)aGa>aTa	p.R839I	PDZRN4_uc001rmq.4_Missense_Mutation_p.R581I|PDZRN4_uc009zjz.3_Missense_Mutation_p.R579I|PDZRN4_uc001rmr.3_Missense_Mutation_p.R466I	NM_001164595	NP_001158067	Q6ZMN7	PZRN4_HUMAN	Homo sapiens PDZ domain containing ring finger 4 (PDZRN4), transcript variant 1, mRNA.	839							ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TCCTCATATAGATATGCAAAC	0.473000														171			14		6.81908e-15	7.41204e-15	1	1	0
TNS1	7145	broad.mit.edu	37	2	218713453	218713453	+	Missense_Mutation	SNP	G	A	A			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr2:218713453G>A	uc002vgt.2	-	16	1810	c.1412C>T	c.(1411-1413)tCg>tTg	p.S471L	TNS1_uc002vgr.2_Missense_Mutation_p.S471L|TNS1_uc002vgs.2_Missense_Mutation_p.S471L|TNS1_uc010zjv.1_Missense_Mutation_p.S471L|TNS1_uc010fvj.1_Missense_Mutation_p.S539L|TNS1_uc010fvk.1_Missense_Mutation_p.S596L|TNS1_uc010fvi.1_Missense_Mutation_p.S158L	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	Homo sapiens tensin 1 (TNS1), mRNA.	471						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGGCACAGCCGAGCCCCCTGC	0.632000														92			3		0	0	1	0	0
EFS	10278	broad.mit.edu	37	14	23828540	23828540	+	Missense_Mutation	SNP	A	G	G	rs147833862		TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr14:23828540A>G	uc001wjo.3	-	3	1755	c.1147T>C	c.(1147-1149)Tat>Cat	p.Y383H	EFS_uc001wjp.3_Missense_Mutation_p.Y290H|EFS_uc010tnm.2_Missense_Mutation_p.Y214H	NM_005864	NP_005855	O43281	EFS_HUMAN	Homo sapiens embryonal Fyn-associated substrate (EFS), transcript variant 1, mRNA.	383					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		AGGTGGACATAGTCATACTCC	0.637000														184			3		0	0	1	0	0
ZNF563	147837	broad.mit.edu	37	19	12430333	12430333	+	Missense_Mutation	SNP	T	C	C			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr19:12430333T>C	uc002mtp.3	-	3	744	c.506A>G	c.(505-507)tAt>tGt	p.Y169C	ZNF563_uc002mtq.2_Missense_Mutation_p.Y169C	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	Homo sapiens zinc finger protein 563 (ZNF563), mRNA.	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						CTTACACTCATAGCGTTTCTT	0.433000														82			43		0	0	1	0	0
SESTD1	91404	broad.mit.edu	37	2	179997121	179997121	+	Silent	SNP	T	C	C			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr2:179997121T>C	uc002uni.4	-	9	1032	c.882A>G	c.(880-882)gaA>gaG	p.E294E		NM_178123	NP_835224	Q86VW0	SESD1_HUMAN	Homo sapiens SEC14 and spectrin domains 1 (SESTD1), mRNA.	294					regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			CTCTTAGTTGTTCTGATCCAG	0.443000														142			4		0	0	1	0	0
TRIM67	440730	broad.mit.edu	37	1	231299576	231299576	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr1:231299576delG	uc009xfn.1	+	0	903	c.861delG	c.(859-861)gcgfs	p.A287fs		NM_001004342	NP_001004342	Q6ZTA4	TRI67_HUMAN	Homo sapiens tripartite motif containing 67 (TRIM67), mRNA.	287						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CGGGAGGCGCGGGGGCGGGGG	0.756													---	4	---	---	2	---					
COG8	84342	broad.mit.edu	37	16	69366761	69366761	+	Frame_Shift_Del	DEL	G	-	-			TCGA-EM-A3O7-01A-11D-A21Z-08	TCGA-EM-A3O7-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	170b4810-6ae0-416c-8f15-01352110ddff	4db51cf4-0222-4e25-bf89-39317d38b490	g.chr16:69366761delG	uc002ewy.2	-	3	1509	c.1438delC	c.(1438-1440)catfs	p.H480fs	PDF_uc002ewx.1_5'Flank	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	Homo sapiens component of oligomeric golgi complex 8 (COG8), mRNA.	480					protein transport	Golgi membrane|Golgi transport complex				breast(3)|kidney(1)|large_intestine(2)|ovary(2)|skin(1)	9						TCAGCGCGATGGAAGGCCAGG	0.502													---	40	---	---	25	---					
