Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOC100233156	100233156	broad.mit.edu	37	GL000218.1	40716	40716	+	Missense_Mutation	SNP	C	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrGL000218.1:40716C>T	uc011mfn.2	-	2	303	c.214G>A	c.(214-216)Gtg>Atg	p.V72M	LOC100233156_uc003jah.2_Missense_Mutation_p.V72M					Homo sapiens tektin 4 pseudogene (LOC100233156), transcript variant 1, non-coding RNA.																		GCCAGGTTCACGGCGTCACAC	0.672000														96			8		0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42832431	42832431	+	RNA	SNP	A	G	G			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:42832431A>G	uc010qey.2	-	2		c.1544T>C								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		TCTTGTGTATAGTAAGGTTTG	0.373000														34			4		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118289	118289	+	RNA	SNP	G	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrGL000205.1:118289G>A	uc002kgk.4	+	0		c.1667G>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		TGAGCTCAGTGGTGCTACCTA	0.512000														163			17		0	0	1	0	0
LOC441666	441666	broad.mit.edu	37	10	42832426	42832426	+	RNA	SNP	T	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:42832426T>C	uc010qey.2	-	2		c.1549A>G								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		AATTCTCTTGTGTATAGTAAG	0.373000														37			4		0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240819	39240819	+	Missense_Mutation	SNP	C	G	G			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:39240819C>G	uc010wfn.2	+	0	361	c.361C>G	c.(361-363)Ctg>Gtg	p.L121V		NM_033061	NP_149050			Homo sapiens keratin associated protein 4-7 (KRTAP4-7), mRNA.											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						ctgctgctgcCTGCGTCCAGT	0.657000														22			5		0	0	1	0	0
MST1P2	11209	broad.mit.edu	37	1	16974182	16974182	+	RNA	SNP	C	A	A	rs144074313	by1000genomes	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:16974182C>A	uc009vow.2	+	4		c.992C>A			MST1P2_uc010ocg.1_Non-coding_Transcript|MST1P2_uc010och.2_Intron|MST1P2_uc010oci.1_Non-coding_Transcript|MST1P2_uc001azk.2_Intron|MST1P2_uc009vox.3_Intron|MST1P2_uc001azm.4_Intron					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 2 (MST1P2), non-coding RNA.																		GAGCATATCCCGTGGAGTACC	0.672000														71			5		0.00116845	0.00116845	1	1	0
LOC441666	441666	broad.mit.edu	37	10	42832122	42832122	+	RNA	SNP	C	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:42832122C>T	uc010qey.2	-	2		c.1853G>A								Homo sapiens zinc finger protein 91 pseudogene (LOC441666), non-coding RNA.																		CAGTAAAAGGCTTTGCCACAT	0.348000														43			4		0	0	1	0	0
X97876	0	broad.mit.edu	37	9	66499716	66499716	+	Missense_Mutation	SNP	A	G	G	rs141617852	by1000genomes	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr9:66499716A>G	uc004aee.1	+	0	526	c.526A>G	c.(526-528)Aat>Gat	p.N176D	X97876_uc004aed.1_Non-coding_Transcript					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).																		CCTGGAGCCCAATCTGCTGGA	0.607000														417			37		0	0	1	0	0
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr9:35906559A>C	uc003zyr.1	+	0	371	c.275A>C	c.(274-276)cAc>cCc	p.H92P	LOC158376_uc003zys.1_5'Flank	NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	Homo sapiens histidine rich carboxyl terminus 1 (HRCT1), mRNA.	92	His-rich.					integral to membrane		p.H92P(2)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccaccacccccgccac	0.682000														49			16		0	0	1	0	0
DDX11	1663	broad.mit.edu	37	12	31237922	31237922	+	Missense_Mutation	SNP	G	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:31237922G>C	uc001rjt.1	+	4	751	c.500G>C	c.(499-501)aGa>aCa	p.R167T	DDX11_uc010sjw.1_Missense_Mutation_p.R167T|DDX11_uc010sjx.1_Non-coding_Transcript|DDX11_uc001rjr.1_Missense_Mutation_p.R167T|DDX11_uc001rjs.1_Missense_Mutation_p.R167T|DDX11_uc001rju.1_5'UTR|DDX11_uc001rjv.1_Missense_Mutation_p.R167T|DDX11_uc001rjw.1_Missense_Mutation_p.R141T|DDX11_uc001rjx.1_5'Flank	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (DDX11), transcript variant 3, mRNA.	167	Glu-rich.|Helicase ATP-binding.				G2/M transition of mitotic cell cycle|S phase of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|RNA binding|protein binding	p.R167T(18)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(11)|large_intestine(5)|lung(23)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	57	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GAAGAAGAAAGAGAGAATCTC	0.612000										Multiple Myeloma(12;0.14)				69			6		0	0	1	0	0
PHF13	148479	broad.mit.edu	37	1	6680069	6680071	+	In_Frame_Del	DEL	GAA	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:6680069_6680071delGAA	uc001aob.4	+	2	719_721	c.348_350delGAA	c.(346-351)ctgaag>ctg	p.K121del		NM_153812	NP_722519	Q86YI8	PHF13_HUMAN	Homo sapiens PHD finger protein 13 (PHF13), mRNA.	121					cell division|chromatin modification|mitotic chromosome condensation	nucleoplasm	chromatin binding|methylated histone residue binding|zinc ion binding			endometrium(3)|large_intestine(1)|lung(3)	7	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;1.46e-33)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.19e-07)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0642)		cggacaagctgaagaagaagaag	0.576													---	405	---	---	11	---					
VAMP3	9341	broad.mit.edu	37	1	7838212	7838214	+	In_Frame_Del	DEL	TCA	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:7838212_7838214delTCA	uc001aol.3	+	3	381_383	c.266_268delTCA	c.(265-270)ttcatc>ttc	p.I94del		NM_004781	NP_004772	Q15836	VAMP3_HUMAN	Homo sapiens vesicle-associated membrane protein 3 (cellubrevin) (VAMP3), mRNA.	94					cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTTATCTTCATCATCATCAT	0.365													---	1070	---	---	7	---					
AADACL3	126767	broad.mit.edu	37	1	12785492	12785493	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:12785492_12785493insT	uc009vnn.1	+	3	815_816	c.582_583insT	c.(580-585)tactgtfs	p.Y194fs	AADACL3_uc001aug.1_Frame_Shift_Ins_p.Y124fs	NM_001103170	NP_001096640	Q5VUY0	ADCL3_HUMAN	Homo sapiens arylacetamide deacetylase-like 3 (AADACL3), transcript variant 1, mRNA.	194							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TCATCTGCTACTGTTTTTTTCA	0.455													---	1139	---	---	11	---					
MST1P9	11223	broad.mit.edu	37	1	17085590	17085595	+	In_Frame_Del	DEL	GCGCTG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:17085590_17085595delGCGCTG	uc010ock.2	-	8	1126_1131	c.1126_1131delCAGCGC	c.(1126-1131)cagcgcdel	p.QR376del	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.4_5'UTR					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 9 (MST1P9), non-coding RNA.									p.K375N(1)|p.Q376_R377delQR(1)|p.Q366_R367delQR(1)		breast(1)|endometrium(11)|kidney(9)|large_intestine(1)|lung(5)|pancreas(1)|prostate(4)|stomach(1)|urinary_tract(1)	34						CAGCGGACCAGCGCTGGCACTGGACA	0.704													---	469	---	---	36	---					
EIF4G3	8672	broad.mit.edu	37	1	21226332	21226332	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:21226332delT	uc001bec.3	-	10	1945	c.1689delA	c.(1687-1689)aaafs	p.K563fs	EIF4G3_uc010odi.2_Frame_Shift_Del_p.K167fs|EIF4G3_uc010odj.2_Frame_Shift_Del_p.K562fs|EIF4G3_uc009vpz.3_Frame_Shift_Del_p.K283fs|EIF4G3_uc001bef.3_Frame_Shift_Del_p.K562fs|EIF4G3_uc001bee.3_Frame_Shift_Del_p.K569fs	NM_003760	NP_003751	O43432	IF4G3_HUMAN	Homo sapiens eukaryotic translation initiation factor 4 gamma, 3 (EIF4G3), transcript variant 3, mRNA.	563					RNA metabolic process|interspecies interaction between organisms|regulation of translational initiation	eukaryotic translation initiation factor 4F complex	RNA cap binding|protein binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CAGCTTTCACTTTTTTTAGGT	0.433													---	1336	---	---	9	---					
PHACTR4	65979	broad.mit.edu	37	1	28800272	28800273	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:28800272_28800273insC	uc001bpy.3	+	5	1295_1296	c.1060_1061insC	c.(1060-1062)tccfs	p.S354fs	PHACTR4_uc001bpv.1_Non-coding_Transcript|PHACTR4_uc001bpw.3_Frame_Shift_Ins_p.S344fs|PHACTR4_uc001bpx.3_Frame_Shift_Ins_p.S328fs	NM_023923	NP_076412	Q8IZ21	PHAR4_HUMAN	Homo sapiens phosphatase and actin regulator 4 (PHACTR4), transcript variant 2, mRNA.	344	Pro-rich.						actin binding|protein phosphatase inhibitor activity	p.P356fs*33(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTCTCCGTCCCCCCCACTG	0.515													---	1084	---	---	9	---					
CCDC28B	79140	broad.mit.edu	37	1	32670247	32670248	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:32670247_32670248delTG	uc021okt.1	+	4	706_707	c.574_575delTG	c.(574-576)tgtfs	p.C192fs	CCDC28B_uc001bul.1_Intron|IQCC_uc001bum.2_5'Flank|IQCC_uc009vua.2_5'Flank|IQCC_uc010ogz.1_5'Flank	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	Homo sapiens coiled-coil domain containing 28B (CCDC28B), mRNA.	0								p.A192V(1)		large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AACCCGTCTATGTGTGTGTGTT	0.500													---	1050	---	---	9	---					
C1orf94	84970	broad.mit.edu	37	1	34666398	34666398	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:34666398delA	uc001bxt.3	+	2	1873	c.1035delA	c.(1033-1035)ccafs	p.P345fs	C1orf94_uc001bxs.4_Frame_Shift_Del_p.P155fs	NM_001134734	NP_116273	Q6P1W5	CA094_HUMAN	Homo sapiens chromosome 1 open reading frame 94 (C1orf94), transcript variant 1, mRNA.	155							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				CCAAGGAGCCAAAAAAGGGTC	0.572													---	536	---	---	9	---					
TMCO2	127391	broad.mit.edu	37	1	40713708	40713709	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:40713708_40713709delTC	uc001cfe.2	+	0	136_137	c.43_44delTC	c.(43-45)tctfs	p.S15fs		NM_001008740	NP_001008740	Q7Z6W1	TMCO2_HUMAN	Homo sapiens transmembrane and coiled-coil domains 2 (TMCO2), mRNA.	15						integral to membrane				kidney(1)|large_intestine(3)|lung(1)|ovary(1)	6	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			CCTCTTAGAGTCTCTCTCTCTC	0.406													---	1086	---	---	12	---					
IPP	3652	broad.mit.edu	37	1	46184897	46184898	+	Frame_Shift_Del	DEL	AC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:46184897_46184898delAC	uc001cou.3	-	5	1430_1431	c.1163_1164delGT	c.(1162-1164)tgtfs	p.C388fs	IPP_uc001cos.4_Frame_Shift_Del_p.C388fs	NM_005897	NP_005888	Q9Y573	IPP_HUMAN	Homo sapiens intracisternal A particle-promoted polypeptide (IPP), transcript variant 1, mRNA.	388						actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					TAGCCCCATAACACACACACAC	0.347													---	356	---	---	10	---					
TRIM33	51592	broad.mit.edu	37	1	114968116	114968118	+	In_Frame_Del	DEL	TGT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:114968116_114968118delTGT	uc001eew.3	-	8	1732_1734	c.1648_1650delACA	c.(1648-1650)acadel	p.T550del	TRIM33_uc010owr.2_In_Frame_Del_p.T140del|TRIM33_uc010ows.2_In_Frame_Del_p.T158del|TRIM33_uc001eex.3_In_Frame_Del_p.T550del	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	Homo sapiens tripartite motif containing 33 (TRIM33), transcript variant a, mRNA.	550	Poly-Thr.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|R-SMAD binding|co-SMAD binding|ligase activity|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGCTGTTGTGTTGTTGTTGTT	0.429			T	RET	papillary thyroid								---	1460	---	---	7	---					
SYCP1	6847	broad.mit.edu	37	1	115537600	115537601	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:115537600_115537601insA	uc001efr.3	+	31	3100_3101	c.2891_2892insA	c.(2890-2892)agafs	p.R964fs	SYCP1_uc010owt.2_Non-coding_Transcript|SYCP1_uc001efq.3_Frame_Shift_Ins_p.R964fs|SYCP1_uc009wgw.3_Frame_Shift_Ins_p.R939fs	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	Homo sapiens synaptonemal complex protein 1 (SYCP1), mRNA.	964	Arg/Lys-rich (basic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAATGGATAGAAAAAAAAAAC	0.356													---	342	---	---	17	---					
NBPF14	25832	broad.mit.edu	37	1	148012532	148012532	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:148012532delT	uc001eqq.3	-	11	1459	c.1427delA	c.(1426-1428)aagfs	p.K476fs	NBPF14_uc001eqe.3_Intron|NBPF14_uc001eqf.3_Intron|NBPF14_uc001eqg.3_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc021ovz.1_Intron|NBPF14_uc021owa.1_Intron|NBPF14_uc021owb.1_Frame_Shift_Del_p.K387fs|NBPF14_uc021owc.1_Frame_Shift_Del_p.K143fs|NBPF14_uc021owe.1_Intron|NBPF14_uc021owf.1_Non-coding_Transcript|NBPF14_uc021owg.1_Frame_Shift_Del_p.K631fs|NBPF14_uc021owh.1_Frame_Shift_Del_p.K387fs|NBPF14_uc010pad.1_5'Flank|NBPF14_uc021owd.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 14 (NBPF14), mRNA.	476	NBPF 5.					cytoplasm		p.K476K(2)|p.K476N(1)|p.E475Q(1)|p.K476Q(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					GCCAACATGCTTTTCCTCCAA	0.443													---	7430	---	---	10	---					
MCL1	4170	broad.mit.edu	37	1	150551492	150551494	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:150551492_150551494delTCC	uc001euz.3	-	0	721_723	c.513_515delGGA	c.(511-516)gaggac>gac	p.E171del	MCL1_uc010pch.2_In_Frame_Del_p.E61del|MCL1_uc021oyf.1_Intron|MCL1_uc001eva.3_In_Frame_Del_p.E171del	NM_021960	NP_068779	Q07820	MCL1_HUMAN	Homo sapiens myeloid cell leukemia sequence 1 (BCL2-related) (MCL1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	171	PEST-like.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)	8	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GTACAACTCGTCCTCCTCCTCCT	0.635													---	414	---	---	7	---					
MRPL9	65005	broad.mit.edu	37	1	151735572	151735573	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:151735572_151735573insC	uc001eyv.3	-	1	288_289	c.203_204insG	c.(202-204)ggcfs	p.G68fs	MRPL9_uc009wmz.3_Non-coding_Transcript|MRPL9_uc010pdk.1_Frame_Shift_Ins_p.G68fs|MRPL9_uc009wna.1_Frame_Shift_Ins_p.G68fs|OAZ3_uc010pdl.2_5'UTR	NM_031420	NP_113608	Q9BYD2	RM09_HUMAN	Homo sapiens mitochondrial ribosomal protein L9 (MRPL9), nuclear gene encoding mitochondrial protein, mRNA.	68					translation	mitochondrial ribosome	structural constituent of ribosome			endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCGGCTTCCGGCCCTCCCCGGC	0.639													---	317	---	---	7	---					
LCE4A	199834	broad.mit.edu	37	1	152681693	152681698	+	In_Frame_Del	DEL	TGTGGT	-	-	rs74871420		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:152681693_152681698delTGTGGT	uc001fak.2	+	0	171_176	c.142_147delTGTGGT	c.(142-147)tgtggtdel	p.CG48del		NM_178356	NP_848133	Q5TA78	LCE4A_HUMAN	Homo sapiens late cornified envelope 4A (LCE4A), mRNA.	48	Cys-rich.				keratinization					endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.116)			CTCTGGGGGCTGTGGTTGCTGCAGCT	0.578													---	610	---	---	14	---					
S100A8	6279	broad.mit.edu	37	1	153362715	153362715	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:153362715delT	uc001fbs.3	-	2	316	c.146delA	c.(145-147)aagfs	p.K49fs		NM_002964	NP_002955	P05109	S10A8_HUMAN	Homo sapiens S100 calcium binding protein A8 (S100A8), mRNA.	49	EF-hand 2.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTCTGCACCCTTTTTCTGTCA	0.507													---	1028	---	---	7	---					
NES	10763	broad.mit.edu	37	1	156642803	156642804	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:156642803_156642804insG	uc001fpq.3	-	3	1309_1310	c.1176_1177insC	c.(1174-1179)cccacafs	p.P392fs	NES_uc021pbh.1_5'Flank	NM_006617	NP_006608	P48681	NEST_HUMAN	Homo sapiens nestin (NES), mRNA.	392	Tail.				G2/M transition of mitotic cell cycle|brain development|embryonic camera-type eye development|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCTGAGGTGTGGGGGGGATGG	0.594													---	846	---	---	7	---					
IPO9	55705	broad.mit.edu	37	1	201843998	201844000	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:201843998_201844000delGAG	uc001gwz.3	+	21	2922_2924	c.2872_2874delGAG	c.(2872-2874)gagdel	p.E962del		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	Homo sapiens importin 9 (IPO9), mRNA.	962					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity	p.E962D(1)		cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						ggaggaggaagaggaggaggagg	0.443													---	511	---	---	8	---					
ZC3H11A	9877	broad.mit.edu	37	1	203786225	203786225	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:203786225delT	uc001hac.3	+	4	643	c.27delT	c.(25-27)tatfs	p.Y9fs	ZC3H11A_uc001had.3_Frame_Shift_Del_p.Y9fs|ZC3H11A_uc001hae.3_Frame_Shift_Del_p.Y9fs|ZC3H11A_uc001haf.3_Frame_Shift_Del_p.Y9fs|ZC3H11A_uc010pqm.2_Intron|ZC3H11A_uc001hag.1_Frame_Shift_Del_p.Y9fs	NM_014827	NP_055642	O75152	ZC11A_HUMAN	Homo sapiens zinc finger CCCH-type containing 11A (ZC3H11A), mRNA.	9							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AAGACTGCTATTTTTTTTTCT	0.373													---	515	---	---	10	---					
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr1:237024474delA	uc001hyi.4	+	19	2516	c.2093delA	c.(2092-2094)caafs	p.Q698fs	MTR_uc010pxw.2_Frame_Shift_Del_p.Q291fs|MTR_uc010pxx.2_Intron|MTR_uc010pxy.2_Frame_Shift_Del_p.Q552fs	NM_000254	NP_000245	Q99707	METH_HUMAN	Homo sapiens 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), mRNA.	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding	p.N697T(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.308													---	444	---	---	7	---					
OTOF	9381	broad.mit.edu	37	2	26693554	26693556	+	In_Frame_Del	DEL	CTT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:26693554_26693556delCTT	uc002rhk.3	-	31	4055_4057	c.3928_3930delAAG	c.(3928-3930)aagdel	p.K1310del	OTOF_uc010yla.2_In_Frame_Del_p.K40del|OTOF_uc002rhh.3_In_Frame_Del_p.K543del|OTOF_uc002rhi.3_In_Frame_Del_p.K620del|OTOF_uc002rhj.3_In_Frame_Del_p.K543del	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	Homo sapiens otoferlin (OTOF), transcript variant 1, mRNA.	1310	Poly-Lys.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGCAGTGCCcttcttcttcttc	0.576													---	457	---	---	9	---					
FAM82A1	151393	broad.mit.edu	37	2	38178783	38178783	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:38178783delT	uc002rqn.2	+	1	551	c.425delT	c.(424-426)attfs	p.I142fs	FAM82A1_uc002rqk.1_Intron|FAM82A1_uc002rql.3_Intron|FAM82A1_uc021vga.1_Intron|FAM82A1_uc002rqm.3_Intron	NM_144713	NP_653314	Q96LZ7	RMD2_HUMAN	Homo sapiens family with sequence similarity 82, member A1 (FAM82A1), transcript variant 1, mRNA.	0						cytoplasm|integral to membrane|microtubule|spindle pole	binding			endometrium(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)	13						AAGAGTGCCATTTTTTTTGAT	0.333													---	471	---	---	8	---					
RPL23AP32	56969	broad.mit.edu	37	2	54756587	54756588	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:54756587_54756588insA	uc010yot.1	+	0	229_230	c.105_106insA	c.(103-108)cacaaafs	p.H35fs	SPTBN1_uc002rxu.3_Intron|SPTBN1_uc002rxv.1_Intron					Homo sapiens ribosomal protein L23a pseudogene 32 (RPL23AP32), non-coding RNA.																		TCCACGGCCACAAAAAAAAGAA	0.540													---	501	---	---	8	---					
RTN4	57142	broad.mit.edu	37	2	55253745	55253746	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:55253745_55253746insT	uc002rye.3	-	2	1787_1788	c.1489_1490insA	c.(1489-1491)atafs	p.I497fs	RTN4_uc002ryd.3_Frame_Shift_Ins_p.I291fs|RTN4_uc002ryf.3_Intron|RTN4_uc002ryg.3_Intron	NM_020532	NP_997404	Q9NQC3	RTN4_HUMAN	Homo sapiens reticulon 4 (RTN4), transcript variant 1, mRNA.	497					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						CTTTTCTTCTATTTTTTTTTCA	0.381													---	544	---	---	9	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:96992793_96992795delGAG	uc002svy.3	+	0	859_861	c.448_450delGAG	c.(448-450)gagdel	p.E155del	ITPRIPL1_uc002svx.3_In_Frame_Del_p.E147del|ITPRIPL1_uc010yuk.2_In_Frame_Del_p.E139del|ITPRIPL1_uc010yul.2_In_Frame_Del_p.E139del	NM_178495	NP_001156996	Q6GPH6	IPIL1_HUMAN	Homo sapiens inositol 1,4,5-trisphosphate receptor interacting protein-like 1 (ITPRIPL1), transcript variant 1, mRNA.	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													---	396	---	---	14	---					
RANBP2	5903	broad.mit.edu	37	2	109371629	109371630	+	Splice_Site	INS	-	TC	TC			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:109371629_109371630insTC	uc002tem.4	+	17	2509	c.2383_splice	c.e17-2	p.Y795_splice		NM_006267	NP_006258	P49792	RBP2_HUMAN	Homo sapiens RAN binding protein 2 (RANBP2), mRNA.	795					carbohydrate metabolic process|glucose transport|mRNA transport|mitotic prometaphase|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	Ran GTPase binding|peptidyl-prolyl cis-trans isomerase activity|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TATTTTTTTTTAGTATTCTCCC	0.312													---	1074	---	---	7	---					
OSBPL6	114880	broad.mit.edu	37	2	179196281	179196281	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:179196281delT	uc002uly.3	+	5	865	c.321delT	c.(319-321)cgtfs	p.R107fs	OSBPL6_uc002ulw.3_Frame_Shift_Del_p.R107fs|OSBPL6_uc002ulx.3_Frame_Shift_Del_p.R107fs|OSBPL6_uc010zfe.2_Frame_Shift_Del_p.R107fs|OSBPL6_uc002ulz.3_Frame_Shift_Del_p.R107fs|OSBPL6_uc002uma.3_Frame_Shift_Del_p.R86fs	NM_001201480	NP_001188409	Q9BZF3	OSBL6_HUMAN	Homo sapiens oxysterol binding protein-like 6 (OSBPL6), transcript variant 3, mRNA.	107	PH.				lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			TCTTGCAGCGTTTTTTTGTCC	0.363													---	1032	---	---	7	---					
SLC11A1	6556	broad.mit.edu	37	2	219252307	219252307	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:219252307delT	uc002vhv.3	+	6	931	c.591delT	c.(589-591)gctfs	p.A197fs	SLC11A1_uc010fvp.1_Frame_Shift_Del_p.A197fs|SLC11A1_uc010fvq.1_Frame_Shift_Del_p.A130fs|SLC11A1_uc010zkc.1_Frame_Shift_Del_p.A130fs|SLC11A1_uc002vhu.1_5'UTR|SLC11A1_uc002vhw.3_Frame_Shift_Del_p.A79fs|SLC11A1_uc010fvr.3_5'UTR	NM_000578	NP_000569	P49279	NRAM1_HUMAN	Homo sapiens solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (SLC11A1), mRNA.	197					L-arginine import|MHC class II biosynthetic process|T cell cytokine production|T cell proliferation involved in immune response|activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|mRNA stabilization|macrophage activation|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCTGGAAGCTTTTTTTGGAC	0.448													---	2014	---	---	9	---					
GAL3ST2	64090	broad.mit.edu	37	2	242738494	242738496	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr2:242738494_242738496delTCC	uc002wcj.1	+	1	175_177	c.44_46delTCC	c.(43-48)atcctc>atc	p.L20del		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	Homo sapiens galactose-3-O-sulfotransferase 2 (GAL3ST2), mRNA.	20					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity	p.L16I(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTCCGGGTCATCCTCCTCCTCCT	0.631													---	392	---	---	9	---					
VENTXP7	391518	broad.mit.edu	37	3	21447902	21447903	+	RNA	INS	-	CT	CT			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:21447902_21447903insCT	uc003ccd.3	+	0		c.685_686insCT								Homo sapiens VENT homeobox pseudogene 7 (VENTXP7), non-coding RNA.																		TGGCATACCACCCCCCACGCCC	0.658													---	31	---	---	10	---					
QRICH1	54870	broad.mit.edu	37	3	49094314	49094316	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:49094314_49094316delTGC	uc010hkq.3	-	3	1613_1615	c.1317_1319delGCA	c.(1315-1320)cagcaa>caa	p.439_440QQ>Q	QRICH1_uc003cvu.3_In_Frame_Del_p.439_440QQ>Q|QRICH1_uc003cvv.3_In_Frame_Del_p.439_440QQ>Q|QRICH1_uc021wxr.1_In_Frame_Del_p.376_377QQ>Q	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	Homo sapiens glutamine-rich 1 (QRICH1), transcript variant 2, mRNA.	439	Gln-rich.									breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		AACTTGGAgttgctgctgctgct	0.562													---	381	---	---	7	---					
LRTM1	57408	broad.mit.edu	37	3	54952381	54952385	+	Splice_Site	DEL	TTGTC	-	-	rs143751942		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:54952381_54952385delTTGTC	uc003dhl.3	-	3	1277	c.1143_splice	c.e3+1		CACNA2D3_uc003dhf.3_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	Homo sapiens leucine-rich repeats and transmembrane domains 1 (LRTM1), mRNA.							integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		ttttttttttttgtcttttGGCAAA	0.312													---	253	---	---	7	---					
LRTM1	57408	broad.mit.edu	37	3	54952382	54952385	+	Splice_Site	DEL	TGTC	-	-	rs143751942		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:54952382_54952385delTGTC	uc003dhl.3	-	3	1277	c.1143_splice	c.e3+1		CACNA2D3_uc003dhf.3_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	Homo sapiens leucine-rich repeats and transmembrane domains 1 (LRTM1), mRNA.							integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		tttttttttttgtcttttGGCAAA	0.314													---	273	---	---	14	---					
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:100148586_100148588delGAT	uc003dtx.4	+	1	1293_1295	c.13_15delGAT	c.(13-15)gatdel	p.D10del		NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	Homo sapiens leukemia NUP98 fusion partner 1 (LNP1), mRNA.	10	Poly-Asp.									cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						GGAGCACAAAGATGATGATGATG	0.507													---	1210	---	---	8	---					
PCOLCE2	26577	broad.mit.edu	37	3	142548586	142548586	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:142548586delT	uc003evd.3	-	5	1120	c.813delA	c.(811-813)aaafs	p.K271fs		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	Homo sapiens procollagen C-endopeptidase enhancer 2 (PCOLCE2), mRNA.	271						extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						TTGTAGGCAGTTTTTTTGGCC	0.383													---	962	---	---	7	---					
VEPH1	79674	broad.mit.edu	37	3	157081226	157081227	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:157081226_157081227insT	uc003fbj.2	-	8	2080_2081	c.1661_1662insA	c.(1660-1662)aacfs	p.N554fs	VEPH1_uc003fbk.2_Frame_Shift_Ins_p.N554fs|VEPH1_uc010hvu.2_Frame_Shift_Ins_p.N554fs	NM_024621	NP_078897	Q14D04	MELT_HUMAN	Homo sapiens ventricular zone expressed PH domain homolog 1 (zebrafish) (VEPH1), transcript variant 1, mRNA.	554						plasma membrane				autonomic_ganglia(1)|breast(5)|cervix(1)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|pancreas(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CTTTGCTGAGGTTTTTTTTTAA	0.396													---	902	---	---	15	---					
HTR3E	285242	broad.mit.edu	37	3	183822596	183822596	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:183822596delA	uc010hxr.3	+	2	683	c.489delA	c.(487-489)ccafs	p.P163fs	HTR3E_uc010hxq.3_Frame_Shift_Del_p.P137fs|HTR3E_uc003fml.4_Frame_Shift_Del_p.P122fs|HTR3E_uc003fmm.3_Frame_Shift_Del_p.P152fs|HTR3E_uc003fmn.3_Frame_Shift_Del_p.P137fs	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member E (HTR3E), mRNA.	137						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			ATAAGACCCCAAAAGGCCTCA	0.428													---	603	---	---	7	---					
ATP13A3	79572	broad.mit.edu	37	3	194147850	194147850	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr3:194147850delA	uc003fty.4	-	27	3481	c.3079delT	c.(3079-3081)tggfs	p.W1027fs	ATP13A3_uc003ftx.4_5'Flank	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	Homo sapiens ATPase type 13A3 (ATP13A3), mRNA.	1027					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		TGTTTGACCCAAAAAAAACCC	0.383													---	311	---	---	7	---					
CRIPAK	285464	broad.mit.edu	37	4	1388441	1388442	+	Frame_Shift_Ins	INS	-	CG	CG	rs144787346	byFrequency	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:1388441_1388442insCG	uc003gdf.2	+	0	3102_3103	c.142_143insCG	c.(142-144)atgfs	p.M48fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	Homo sapiens cysteine-rich PAK1 inhibitor (CRIPAK), mRNA.	48					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTGCTCACACATGCCCATGTGG	0.644													---	2072	---	---	15	---					
CRIPAK	285464	broad.mit.edu	37	4	1388530	1388531	+	Frame_Shift_Ins	INS	-	CA	CA			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:1388530_1388531insCA	uc003gdf.2	+	0	3191_3192	c.231_232insCA	c.(229-234)gctcatfs	p.A77fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	Homo sapiens cysteine-rich PAK1 inhibitor (CRIPAK), mRNA.	77					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GCCCACCTGCTCATGTGCCCAT	0.644													---	1855	---	---	11	---					
CRIPAK	285464	broad.mit.edu	37	4	1389425	1389426	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:1389425_1389426delCA	uc003gdf.2	+	0	4086_4087	c.1126_1127delCA	c.(1126-1128)cacfs	p.H376fs		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	Homo sapiens cysteine-rich PAK1 inhibitor (CRIPAK), mRNA.	376	Interaction with PAK1.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CCCGCCTGCTCACACGTGCCCA	0.639													---	1679	---	---	8	---					
HGFAC	3083	broad.mit.edu	37	4	3443798	3443800	+	In_Frame_Del	DEL	CTG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:3443798_3443800delCTG	uc003ghc.3	+	0	73_75	c.70_72delCTG	c.(70-72)ctgdel	p.L29del	HGFAC_uc010icw.3_In_Frame_Del_p.L29del	NM_001528	NP_001519	Q04756	HGFA_HUMAN	Homo sapiens HGF activator (HGFAC), mRNA.	29					proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCTCCTCCTCCTGCTGCTGCTGC	0.714													---	189	---	---	7	---					
PROM1	8842	broad.mit.edu	37	4	15995680	15995680	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:15995680delT	uc003goo.2	-	14	1909	c.1697delA	c.(1696-1698)aatfs	p.N566fs	PROM1_uc003gor.2_Frame_Shift_Del_p.N566fs|PROM1_uc003gos.2_Frame_Shift_Del_p.N557fs|PROM1_uc003got.2_Frame_Shift_Del_p.N566fs|PROM1_uc003gou.2_Frame_Shift_Del_p.N557fs|PROM1_uc003gop.2_Frame_Shift_Del_p.N557fs|PROM1_uc003goq.3_Frame_Shift_Del_p.N557fs	NM_006017	NP_006008	O43490	PROM1_HUMAN	Homo sapiens prominin 1 (PROM1), transcript variant 1, mRNA.	566					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding	p.N565N(2)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						AGTGCCTCTATTTTTTTTGCA	0.428													---	475	---	---	8	---					
LAP3	51056	broad.mit.edu	37	4	17585226	17585226	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:17585226delA	uc003gph.1	+	4	662	c.500delA	c.(499-501)caafs	p.Q167fs	LAP3_uc010ieg.3_3'UTR	NM_015907	NP_056991	P28838	AMPL_HUMAN	Homo sapiens leucine aminopeptidase 3 (LAP3), mRNA.	167					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|urinary_tract(1)	20						GACCTAAAGCAAAAAAAGAAG	0.547													---	560	---	---	7	---					
AASDH	132949	broad.mit.edu	37	4	57220269	57220269	+	Frame_Shift_Del	DEL	A	-	-	rs148777026		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:57220269delA	uc003hbn.3	-	7	1472	c.1319delT	c.(1318-1320)ttgfs	p.L440fs	AASDH_uc010ihb.3_5'UTR|AASDH_uc003hbo.3_Frame_Shift_Del_p.L340fs|AASDH_uc011caa.2_Frame_Shift_Del_p.L287fs|AASDH_uc011cab.2_Intron|AASDH_uc010ihc.3_Frame_Shift_Del_p.L440fs|AASDH_uc003hbp.3_Frame_Shift_Del_p.L440fs	NM_181806	NP_861522	Q4L235	ACSF4_HUMAN	Homo sapiens aminoadipate-semialdehyde dehydrogenase (AASDH), mRNA.	440					fatty acid metabolic process		ATP binding|acid-thiol ligase activity|acyl carrier activity|cofactor binding	p.?(1)		endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				TTTTCGTCCCAAAAAAAAAAT	0.363													---	360	---	---	19	---					
C4orf26	152816	broad.mit.edu	37	4	76489680	76489680	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:76489680delA	uc011cbo.2	+	2	503	c.468delA	c.(466-468)gcafs	p.A156fs	C4orf26_uc011cbn.2_Non-coding_Transcript|C4orf26_uc003hip.2_3'UTR	NM_001206981	NP_001193910	Q17RF5	CD026_HUMAN	Homo sapiens chromosome 4 open reading frame 26 (C4orf26), transcript variant 1, mRNA.	0						extracellular region				kidney(1)|large_intestine(4)|stomach(1)	6			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			ATACTGAAGCAAAAAAAAGCC	0.363													---	526	---	---	8	---					
PTPN13	5783	broad.mit.edu	37	4	87622606	87622607	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:87622606_87622607insA	uc003hpz.3	+	6	1327_1328	c.847_848insA	c.(847-849)gaafs	p.E283fs	PTPN13_uc003hpy.3_Frame_Shift_Ins_p.E283fs|PTPN13_uc003hqa.3_Frame_Shift_Ins_p.E283fs|PTPN13_uc003hqb.3_Frame_Shift_Ins_p.E283fs	NM_080683	NP_542414	Q12923	PTN13_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13), transcript variant 1, mRNA.	283						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TAGTGGCCCAGAAAAAAAACCC	0.401													---	236	---	---	7	---					
HERC5	51191	broad.mit.edu	37	4	89381265	89381266	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:89381265_89381266insA	uc003hrt.3	+	2	562_563	c.409_410insA	c.(409-411)gaafs	p.E137fs		NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	Homo sapiens hect domain and RLD 5 (HERC5), mRNA.	137					ISG15-protein conjugation|innate immune response|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		CATTTTACAAGAAAAAAAAATA	0.272													---	177	---	---	8	---					
NAP1L5	266812	broad.mit.edu	37	4	89618484	89618486	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:89618484_89618486delTCC	uc003hrx.3	-	0	538_540	c.420_422delGGA	c.(418-423)gaggaa>gaa	p.140_141EE>E	HERC3_uc011cdn.1_Intron|HERC3_uc003hrw.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	Homo sapiens nucleosome assembly protein 1-like 5 (NAP1L5), mRNA.	140	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		gtactcctcttcctcctcctcct	0.606													---	389	---	---	7	---					
CXXC4	80319	broad.mit.edu	37	4	105412465	105412467	+	Splice_Site	DEL	GCC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr4:105412465_105412467delGCC	uc003hxg.3	-	1	1	c.-14_splice	c.e1-1		AK094561_uc003hxh.1_Intron|CXXC4_uc010ilo.3_Intron	NM_025212	NP_079488	Q9H2H0	CXXC4_HUMAN	Homo sapiens CXXC finger protein 4 (CXXC4), mRNA.						Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TGGTCCTgctgccgccgccgccg	0.695													---	334	---	---	11	---					
DNAH5	1767	broad.mit.edu	37	5	13919383	13919383	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:13919383delT	uc003jfd.2	-	6	919	c.877delA	c.(877-879)agafs	p.R293fs	DNAH5_uc003jfe.1_Non-coding_Transcript	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	Homo sapiens dynein, axonemal, heavy chain 5 (DNAH5), mRNA.	293	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGGAGAGTCTTTTTTTCCAG	0.517									Kartagener syndrome				---	1278	---	---	8	---					
CDH10	1008	broad.mit.edu	37	5	24492973	24492973	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:24492973delA	uc003jgr.2	-	9	2083	c.1577delT	c.(1576-1578)ttcfs	p.F526fs	CDH10_uc011cnu.2_Non-coding_Transcript	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	Homo sapiens cadherin 10, type 2 (T2-cadherin) (CDH10), mRNA.	526	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.F525V(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTAAACTGAAAAAAAATTT	0.313										HNSCC(23;0.051)			---	1235	---	---	12	---					
PAM	5066	broad.mit.edu	37	5	102309949	102309949	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:102309949delA	uc003knt.3	+	13	1665	c.1292delA	c.(1291-1293)caafs	p.Q431fs	PAM_uc003knw.3_Frame_Shift_Del_p.Q431fs|PAM_uc003kns.3_Intron|PAM_uc003knu.3_Frame_Shift_Del_p.Q431fs|PAM_uc011cuz.2_Frame_Shift_Del_p.Q334fs|PAM_uc003knv.3_Frame_Shift_Del_p.Q431fs|PAM_uc003knx.1_Intron|PAM_uc003kny.1_Non-coding_Transcript	NM_000919	NP_000910	P19021	AMD_HUMAN	Homo sapiens peptidylglycine alpha-amidating monooxygenase (PAM), transcript variant 1, mRNA.	431	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	AATGTAGTCCAAAAAAAGGAT	0.423													---	508	---	---	7	---					
CSNK1G3	1456	broad.mit.edu	37	5	122881495	122881495	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:122881495delA	uc003ktm.3	+	1	857	c.138delA	c.(136-138)ggafs	p.G46fs	CSNK1G3_uc003ktl.3_Frame_Shift_Del_p.G46fs|CSNK1G3_uc003ktn.3_Frame_Shift_Del_p.G46fs|CSNK1G3_uc003kto.3_Frame_Shift_Del_p.G46fs|CSNK1G3_uc011cwr.2_Intron|CSNK1G3_uc011cws.2_Intron|CSNK1G3_uc010jda.3_Frame_Shift_Del_p.G46fs	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	Homo sapiens casein kinase 1, gamma 3 (CSNK1G3), transcript variant 1, mRNA.	46	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(1)	15		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		TTAGAGTTGGAAAAAAAATTG	0.363													---	538	---	---	8	---					
SLC22A4	6583	broad.mit.edu	37	5	131676327	131676327	+	Frame_Shift_Del	DEL	T	-	-	rs72552721		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:131676327delT	uc003kwq.3	+	8	1679	c.1514delT	c.(1513-1515)cttfs	p.L505fs	LOC553103_uc021ydj.1_Intron	NM_003059	NP_003050	Q9H015	S22A4_HUMAN	Homo sapiens solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (SLC22A4), mRNA.	505					body fluid secretion|sodium ion transport	apical plasma membrane|integral to plasma membrane|mitochondrion	ATP binding|PDZ domain binding|carnitine transporter activity|cation:cation antiporter activity|secondary active organic cation transmembrane transporter activity|symporter activity	p.E509fs*1(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|urinary_tract(1)	16		all_cancers(142;0.0752)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	ATCCTCACCCTTTTTTTCCCT	0.418													---	1128	---	---	7	---					
PCDHB4	56131	broad.mit.edu	37	5	140502486	140502487	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:140502486_140502487insA	uc003lip.1	+	0	906_907	c.906_907insA	c.(904-909)ttgaaafs	p.L302fs		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	Homo sapiens protocadherin beta 4 (PCDHB4), mRNA.	302	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding	p.K305fs*12(1)|p.K303K(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATACTGTTGAAAAAAAAATT	0.366													---	930	---	---	13	---					
SPRY4	81848	broad.mit.edu	37	5	141694361	141694363	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:141694361_141694363delTGC	uc010jgi.1	-	2	621_623	c.380_382delGCA	c.(379-384)agcaca>aca	p.S127del	SPRY4_uc003lml.2_In_Frame_Del_p.S104del|SPRY4_uc021yet.1_In_Frame_Del_p.S104del	NM_030964	NP_001120968	Q9C004	SPY4_HUMAN	Homo sapiens sprouty homolog 4 (Drosophila) (SPRY4), transcript variant 1, mRNA.	104					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(1)	18		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGAGGATGTGCTGCTGCTGCT	0.660									Testicular Cancer, Familial Clustering of				---	497	---	---	7	---					
PPARGC1B	133522	broad.mit.edu	37	5	149216457	149216459	+	In_Frame_Del	DEL	GGA	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:149216457_149216459delGGA	uc003lrc.3	+	7	2530_2532	c.2439_2441delGGA	c.(2437-2442)ggggag>ggg	p.E818del	PPARGC1B_uc003lrb.2_In_Frame_Del_p.E818del|PPARGC1B_uc003lrd.3_In_Frame_Del_p.E779del|PPARGC1B_uc021yfr.1_In_Frame_Del_p.E754del|PPARGC1B_uc003lre.1_In_Frame_Del_p.E797del|PPARGC1B_uc003lrf.3_In_Frame_Del_p.E797del	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	Homo sapiens peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B), transcript variant 1, mRNA.	818	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|RNA binding|RNA polymerase II transcription cofactor activity|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity	p.E818G(1)		NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			aggaagaaggggaggaggaggag	0.606													---	481	---	---	9	---					
TIMD4	91937	broad.mit.edu	37	5	156378745	156378747	+	In_Frame_Del	DEL	TTG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr5:156378745_156378747delTTG	uc003lwh.2	-	2	512_514	c.455_457delCAA	c.(454-459)acaagc>agc	p.T152del	TIMD4_uc010jii.2_In_Frame_Del_p.T152del	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	Homo sapiens T-cell immunoglobulin and mucin domain containing 4 (TIMD4), transcript variant 1, mRNA.	152	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGTGGGGCTTGTTGTTGTTGT	0.537													---	1469	---	---	15	---					
CYP21A1P	1590	broad.mit.edu	37	6	31975223	31975224	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:31975223_31975224insT	uc021yve.1	+	4	1400_1401	c.838_839insT	c.(838-840)gttfs	p.V280fs				Q5ST44	Q5ST44_HUMAN	Homo sapiens cytochrome P450, family 21, subfamily A, polypeptide 1 pseudogene (CYP21A1P), non-coding RNA.	276							electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										CTGGGCCGTGGTTTTTTTTGCT	0.614													---	819	---	---	7	---					
RING1	6015	broad.mit.edu	37	6	33178989	33178990	+	Frame_Shift_Ins	INS	-	G	G			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:33178989_33178990insG	uc003odk.3	+	4	704_705	c.510_511insG	c.(508-513)agtgggfs	p.S170fs	RING1_uc011dqx.1_Frame_Shift_Ins_p.S170fs|RING1_uc003odl.3_Frame_Shift_Ins_p.S141fs	NM_002931	NP_002922	Q06587	RING1_HUMAN	Homo sapiens ring finger protein 1 (RING1), mRNA.	170	Necessary for transcriptional repression (By similarity).				histone H2A monoubiquitination|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	PcG protein complex|cytoplasm|nuclear speck	protein binding|zinc ion binding	p.G171V(1)		endometrium(5)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|skin(4)	17						CAACGATGAGTGGGGGGGAAGG	0.619													---	1035	---	---	7	---					
TREML2	79865	broad.mit.edu	37	6	41168714	41168716	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:41168714_41168716delCAG	uc010jxm.1	-	0	210_212	c.31_33delCTG	c.(31-33)ctgdel	p.L11del		NM_024807	NP_079083	Q5T2D2	TRML2_HUMAN	Homo sapiens triggering receptor expressed on myeloid cells-like 2 (TREML2), mRNA.	11					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTGTGGCCACAGCAGCAGCAGC	0.631													---	192	---	---	9	---					
ZNF318	24149	broad.mit.edu	37	6	43323502	43323502	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:43323502delT	uc003oux.3	-	3	1648	c.1570delA	c.(1570-1572)aggfs	p.R524fs	ZNF318_uc003ouw.3_Non-coding_Transcript	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	Homo sapiens zinc finger protein 318 (ZNF318), mRNA.	524					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTACGTCGCCTTTTTTCCTGT	0.493													---	1894	---	---	13	---					
RUNX2	860	broad.mit.edu	37	6	45390446	45390448	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:45390446_45390448delCAG	uc011dvx.2	+	2	385_387	c.175_177delCAG	c.(175-177)cagdel	p.Q71del	RUNX2_uc011dvy.2_In_Frame_Del_p.Q71del|RUNX2_uc003oxt.3_In_Frame_Del_p.Q57del	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 1, mRNA.	71	Poly-Gln.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						gcagcagcaacagcagcagcagc	0.729													---	181	---	---	7	---					
KLHL31	401265	broad.mit.edu	37	6	53519759	53519759	+	Frame_Shift_Del	DEL	T	-	-	rs72352601		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:53519759delT	uc003pcb.4	-	1	453	c.312delA	c.(310-312)aaafs	p.K104fs		NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	Homo sapiens kelch-like 31 (Drosophila) (KLHL31), mRNA.	104	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					TTGACGGGTCTTTTTTTAGGA	0.423													---	784	---	---	7	---					
COX7A2	1347	broad.mit.edu	37	6	75950901	75950901	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:75950901delT	uc003phv.2	-	1	293	c.195delA	c.(193-195)aaafs	p.K65fs	COX7A2_uc021zbx.1_Non-coding_Transcript	NM_001865	NP_001856	P14406	CX7A2_HUMAN	Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 2 (liver) (COX7A2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	33						mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity			kidney(2)|lung(1)	3						CCTGGAACAGTTTTTGCTTCT	0.343													---	1033	---	---	7	---					
PHIP	55023	broad.mit.edu	37	6	79655961	79655961	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:79655961delT	uc011dyp.2	-	37	4610	c.4384delA	c.(4384-4386)aggfs	p.R1462fs	PHIP_uc003piq.3_Frame_Shift_Del_p.R487fs|PHIP_uc003pir.3_Frame_Shift_Del_p.R1463fs|IRAK1BP1_uc010kbg.1_Non-coding_Transcript|PHIP_uc003pio.4_Frame_Shift_Del_p.R349fs	NM_017934	NP_060404	Q8WWQ0	PHIP_HUMAN	Homo sapiens pleckstrin homology domain interacting protein (PHIP), mRNA.	1463					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TTTAAGATCCTTTTTTTCCTT	0.358													---	791	---	---	8	---					
TTK	7272	broad.mit.edu	37	6	80751896	80751897	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:80751896_80751897insA	uc003pjc.3	+	21	2662_2663	c.2551_2552insA	c.(2551-2553)gaafs	p.E851fs	TTK_uc003pjb.4_Frame_Shift_Ins_p.E850fs	NM_003318	NP_003309	P33981	TTK_HUMAN	Homo sapiens TTK protein kinase (TTK), transcript variant 1, mRNA.	851					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R838fs*4(3)|p.R838fs*>4(2)|p.R838fs*>5(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		CAAGACTTTTGAAAAAAAAAGG	0.302													---	399	---	---	7	---					
CYB5R4	51167	broad.mit.edu	37	6	84634230	84634231	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:84634230_84634231insA	uc003pkf.3	+	9	865_866	c.733_734insA	c.(733-735)caafs	p.Q245fs		NM_016230	NP_057314	Q7L1T6	NB5R4_HUMAN	Homo sapiens cytochrome b5 reductase 4 (CYB5R4), mRNA.	245	CS.				cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	NAD(P)H oxidase activity|cytochrome-b5 reductase activity|heme binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		GATTGTTCTACAAAAAAAAGAG	0.337													---	456	---	---	10	---					
SYNCRIP	10492	broad.mit.edu	37	6	86332353	86332354	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:86332353_86332354insT	uc003pla.2	-	7	1395_1396	c.854_855insA	c.(853-855)aacfs	p.N285fs	SYNCRIP_uc003pku.3_Frame_Shift_Ins_p.N285fs|SYNCRIP_uc003pkv.3_Frame_Shift_Ins_p.N285fs|SYNCRIP_uc003pkw.3_Frame_Shift_Ins_p.N285fs|SYNCRIP_uc003pkx.3_Frame_Shift_Ins_p.N133fs|SYNCRIP_uc003pky.3_Frame_Shift_Ins_p.N187fs|SYNCRIP_uc003pkz.2_Frame_Shift_Ins_p.N285fs	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	Homo sapiens synaptotagmin binding, cytoplasmic RNA interacting protein (SYNCRIP), transcript variant 1, mRNA.	285	RRM 2.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		AAAAGCCTCTGTTTTTTTTCTT	0.411													---	929	---	---	11	---					
GABRR2	2570	broad.mit.edu	37	6	89975427	89975429	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:89975427_89975429delAAG	uc003pnb.2	-	6	875_877	c.867_869delCTT	c.(865-870)ttcttg>ttg	p.F289del	GABRR2_uc011dzx.1_In_Frame_Del_p.F165del	NM_002043	NP_002034	P28476	GBRR2_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) receptor, rho 2 (GABRR2), mRNA.	289					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	GABA-A receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TGTTTGGAGCAAGAAGAAGAAGA	0.517													---	339	---	---	8	---					
FOXO3	2309	broad.mit.edu	37	6	108985176	108985177	+	Frame_Shift_Ins	INS	-	G	G	rs34133353		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:108985176_108985177insG	uc003psk.2	+	2	1456_1457	c.1140_1141insG	c.(1138-1143)gatgggfs	p.D380fs	FOXO3_uc003psm.2_Frame_Shift_Ins_p.D380fs|FOXO3_uc011ean.1_Frame_Shift_Ins_p.D160fs|FOXO3_uc010kdj.1_Frame_Shift_Ins_p.D160fs	NM_201559	NP_963853	O43524	FOXO3_HUMAN	Homo sapiens forkhead box O3 (FOXO3), transcript variant 2, mRNA.	380					antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(5)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	26		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		ATCTGAATGATGGGCTGACTGA	0.574													---	275	---	---	8	---					
OLIG3	167826	broad.mit.edu	37	6	137815210	137815212	+	In_Frame_Del	DEL	TGG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:137815210_137815212delTGG	uc003qhp.1	-	0	320_322	c.96_98delCCA	c.(94-99)caccag>cag	p.H32del		NM_175747	NP_786923	Q7RTU3	OLIG3_HUMAN	Homo sapiens oligodendrocyte transcription factor 3 (OLIG3), mRNA.	32	Poly-His.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.Q33K(1)		endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		ACGGCTCTCCtggtggtggtggt	0.596													---	526	---	---	9	---					
MTHFD1L	25902	broad.mit.edu	37	6	151358163	151358164	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:151358163_151358164insA	uc021zgs.1	+	25	2904_2905	c.2760_2761insA	c.(2758-2763)gacaaafs	p.D920fs	MTHFD1L_uc011een.2_Non-coding_Transcript|MTHFD1L_uc003qob.3_Frame_Shift_Ins_p.D919fs|MTHFD1L_uc021zgt.1_Frame_Shift_Ins_p.D854fs|MTHFD1L_uc003qoc.3_Frame_Shift_Ins_p.D867fs	NM_001242767	NP_001229696	Q6UB35	C1TM_HUMAN	Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	919	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity	p.L914fs*14(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		ACCAACCTGACAAAAAAGGTGT	0.480													---	524	---	---	12	---					
MLLT4	4301	broad.mit.edu	37	6	168317900	168317900	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr6:168317900delT	uc021zik.1	+	18	2872	c.2553delT	c.(2551-2553)cctfs	p.P851fs	MLLT4_uc003qwb.1_Frame_Shift_Del_p.P876fs|MLLT4_uc003qwc.2_Frame_Shift_Del_p.P892fs|MLLT4_uc021zij.1_Frame_Shift_Del_p.P876fs|MLLT4_uc021zim.1_Frame_Shift_Del_p.P438fs|MLLT4_uc003qwg.1_Frame_Shift_Del_p.P201fs	NM_001040000	NP_001035089	P55196	AFAD_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (MLLT4), transcript variant 2, mRNA.	892	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		CTGATGAGCCTTTTATCCCAA	0.398			T	MLL	AL								---	885	---	---	7	---					
STK31	56164	broad.mit.edu	37	7	23775340	23775341	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr7:23775340_23775341insA	uc003sws.4	+	6	734_735	c.667_668insA	c.(667-669)gaafs	p.E223fs	STK31_uc003swt.4_Frame_Shift_Ins_p.E200fs|STK31_uc011jze.2_Frame_Shift_Ins_p.E223fs|STK31_uc010kuq.3_Frame_Shift_Ins_p.E200fs	NM_031414	NP_116562	Q9BXU1	STK31_HUMAN	Homo sapiens serine/threonine kinase 31 (STK31), transcript variant 1, mRNA.	223							ATP binding|nucleic acid binding|protein serine/threonine kinase activity	p.E223V(2)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CATCTGTGAGGAAAAAAAATTG	0.470													---	509	---	---	7	---					
PPP1R17	10842	broad.mit.edu	37	7	31735179	31735179	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr7:31735179delA	uc003tcl.3	+	2	505	c.179delA	c.(178-180)caafs	p.Q60fs	PPP1R17_uc011kaf.2_Intron	NM_006658	NP_006649	O96001	GSUB_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 17 (PPP1R17), transcript variant 1, mRNA.	60					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction											GAGTCAGACCAAAAAAAACCA	0.438													---	779	---	---	11	---					
PURB	5814	broad.mit.edu	37	7	44924044	44924046	+	In_Frame_Del	DEL	CGC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr7:44924044_44924046delCGC	uc003tme.3	-	0	915_917	c.902_904delGCG	c.(901-906)ggcgaa>gaa	p.G301del		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	Homo sapiens purine-rich element binding protein B (PURB), mRNA.	301					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding			large_intestine(2)|lung(3)|prostate(1)|skin(1)	7						TCTGACTCTTCGCCGCCGCCGCT	0.576													---	728	---	---	8	---					
WBSCR28	135886	broad.mit.edu	37	7	73279462	73279463	+	Frame_Shift_Ins	INS	-	C	C	rs150108862	by1000genomes	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr7:73279462_73279463insC	uc003tzk.2	+	1	248_249	c.212_213insC	c.(211-213)tgcfs	p.C71fs	WBSCR28_uc003tzl.2_5'UTR	NM_182504	NP_872310	Q6UE05	WBS28_HUMAN	Homo sapiens Williams-Beuren syndrome chromosome region 28 (WBSCR28), mRNA.	71						integral to membrane				breast(2)|kidney(2)|lung(6)|skin(1)	11		Lung NSC(55;0.159)				GCTGCAGCCTGCCCCCTGGGCC	0.663													---	714	---	---	10	---					
DTX2	113878	broad.mit.edu	37	7	76112249	76112249	+	Frame_Shift_Del	DEL	A	-	-	rs147779783	byFrequency	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr7:76112249delA	uc011kgk.1	+	2	772	c.420delA	c.(418-420)ccafs	p.P140fs	DTX2_uc003uff.4_Frame_Shift_Del_p.P231fs|DTX2_uc003ufg.4_Frame_Shift_Del_p.P231fs|DTX2_uc003ufh.4_Frame_Shift_Del_p.P231fs|DTX2_uc003ufj.4_Frame_Shift_Del_p.P231fs	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	Homo sapiens deltex homolog 2 (Drosophila) (DTX2), transcript variant 1, mRNA.	231	WWE 2.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						AGCACCCCCCACACAGGACCG	0.657													---	1475	---	---	8	---					
RP1L1	94137	broad.mit.edu	37	8	10467706	10467707	+	In_Frame_Ins	INS	-	CCC	CCC			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr8:10467706_10467707insCCC	uc003wtc.3	-	3	4130_4131	c.3901_3902insGGG	c.(3901-3903)gtg>gGGGtg	p.1300_1301insG		NM_178857	NP_849188	A6NKC6	A6NKC6_HUMAN	Homo sapiens retinitis pigmentosa 1-like 1 (RP1L1), mRNA.	1300					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CTCTAATTGCACCTCTTCTTGC	0.495													---	629	---	---	7	---					
SFTPC	6440	broad.mit.edu	37	8	22021060	22021061	+	Splice_Site	DEL	GT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr8:22021060_22021061delGT	uc003xaw.4	+	7	1285	c.582_splice	c.e7+1	p.Q194_splice	SFTPC_uc003xax.4_Splice_Site_p.Q145_splice|SFTPC_uc003xay.4_Splice_Site_p.Q145_splice|SFTPC_uc003xaz.3_Splice_Site_p.Q145_splice|SFTPC_uc011kza.1_Intron|SFTPC_uc022asz.1_5'Flank|BMP1_uc011kzb.2_5'Flank|BMP1_uc003xbf.3_5'Flank|BMP1_uc003xbb.3_5'Flank|BMP1_uc003xbc.3_5'Flank|BMP1_uc003xbd.3_5'Flank|BMP1_uc003xbe.3_5'Flank|BMP1_uc011kzc.2_5'Flank|BMP1_uc003xbg.3_5'Flank|BMP1_uc003xbh.3_5'Flank|BMP1_uc003xbi.3_5'Flank	NM_001172357	NP_001165828	P11686	PSPC_HUMAN	Homo sapiens surfactant protein C (SFTPC), transcript variant 3, mRNA.	145	BRICHOS.				respiratory gaseous exchange	extracellular space		p.M146fs*41(1)		autonomic_ganglia(1)|large_intestine(1)|lung(1)	3				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CAACTTCCAGGTGTGTGTGTGT	0.545													---	147	---	---	9	---					
PXDNL	137902	broad.mit.edu	37	8	52359596	52359596	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr8:52359596delT	uc003xqu.4	-	11	1594	c.1493delA	c.(1492-1494)aagfs	p.K498fs		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	Homo sapiens peroxidasin homolog (Drosophila)-like (PXDNL), mRNA.	498	Ig-like C2-type 3.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CACAGACACCTTTTTCACCCC	0.448													---	941	---	---	8	---					
PCMTD1	115294	broad.mit.edu	37	8	52733063	52733063	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr8:52733063delT	uc003xqx.4	-	5	1263	c.922delA	c.(922-924)atgfs	p.M308fs	PCMTD1_uc011ldm.2_Frame_Shift_Del_p.M178fs|PCMTD1_uc011ldn.2_Frame_Shift_Del_p.M120fs|PCMTD1_uc010lya.3_Frame_Shift_Del_p.M232fs	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	Homo sapiens protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 (PCMTD1), mRNA.	308						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				tcctcttccattttttcatcc	0.373													---	581	---	---	22	---					
CSMD3	114788	broad.mit.edu	37	8	113662425	113662425	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr8:113662425delT	uc003ynu.3	-	18	3317	c.3158delA	c.(3157-3159)aacfs	p.N1053fs	CSMD3_uc003yns.3_Frame_Shift_Del_p.N325fs|CSMD3_uc003ynt.3_Frame_Shift_Del_p.N1013fs|CSMD3_uc011lhx.2_Frame_Shift_Del_p.N949fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	Homo sapiens CUB and Sushi multiple domains 3 (CSMD3), transcript variant a, mRNA.	1053	Sushi 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCACCAGTGGTTTTTTTCGCA	0.378										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			---	675	---	---	9	---					
COL22A1	169044	broad.mit.edu	37	8	139809072	139809072	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr8:139809072delT	uc003yvd.3	-	11	2033	c.1586delA	c.(1585-1587)aagfs	p.K529fs		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	Homo sapiens collagen, type XXII, alpha 1 (COL22A1), mRNA.	529	Collagen-like 2.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTTCACCCTTTTCCCCTTG	0.463										HNSCC(7;0.00092)			---	1495	---	---	7	---					
TOPORS	10210	broad.mit.edu	37	9	32542262	32542262	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr9:32542262delT	uc003zrb.3	-	2	2453	c.2261delA	c.(2260-2262)aatfs	p.N754fs	TOPORS_uc003zrc.3_Frame_Shift_Del_p.N689fs	NM_005802	NP_001182551	Q9NS56	TOPRS_HUMAN	Homo sapiens topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase (TOPORS), transcript variant 1, mRNA.	754	Arg-rich.|Interaction with TOP1.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	PML body|nuclear speck	DNA binding|DNA topoisomerase I binding|SUMO ligase activity|antigen binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ACTGTGATTATTTTTTTTCCT	0.428													---	774	---	---	7	---					
OR1J2	26740	broad.mit.edu	37	9	125273859	125273859	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr9:125273859delT	uc011lyv.2	+	0	779	c.779delT	c.(778-780)cttfs	p.L260fs	OR1J2_uc004bmj.2_Frame_Shift_Del_p.L260fs	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	Homo sapiens olfactory receptor, family 1, subfamily J, member 2 (OR1J2), mRNA.	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L260F(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						GGCCAGTACCTTTTCCCGACT	0.478													---	1135	---	---	7	---					
PRDM12	59335	broad.mit.edu	37	9	133543701	133543702	+	Splice_Site	DEL	GT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr9:133543701_133543702delGT	uc004bzt.1	+	3	630	c.570_splice	c.e3+1	p.E190_splice		NM_021619	NP_067632	Q9H4Q4	PRD12_HUMAN	Homo sapiens PR domain containing 12 (PRDM12), mRNA.	190	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GGCCATTGAGGTGTGTGTGTGT	0.594													---	386	---	---	24	---					
FRMD4A	55691	broad.mit.edu	37	10	13699134	13699142	+	In_Frame_Del	DEL	CGCCCCCCG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:13699134_13699142delCGCCCCCCG	uc001ims.3	-	21	2799_2807	c.2447_2455delCGGGGGGCG	c.(2446-2457)gcggggggcggt>ggt	p.AGG816del	FRMD4A_uc009xjf.1_In_Frame_Del_p.AGG816del	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	Homo sapiens FERM domain containing 4A (FRMD4A), mRNA.	816						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						AGGTACACAccgccccccgcgccccccgc	0.761													---	22	---	---	13	---					
KIAA1217	56243	broad.mit.edu	37	10	24822125	24822127	+	In_Frame_Del	DEL	GAA	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:24822125_24822127delGAA	uc001iru.4	+	15	3776_3778	c.3373_3375delGAA	c.(3373-3375)gaadel	p.E1129del	KIAA1217_uc001irs.3_In_Frame_Del_p.E1049del|KIAA1217_uc001irt.4_In_Frame_Del_p.E1094del|KIAA1217_uc010qcy.2_In_Frame_Del_p.E1093del|KIAA1217_uc010qcz.2_In_Frame_Del_p.E1094del|KIAA1217_uc001irw.3_In_Frame_Del_p.E812del|KIAA1217_uc001irz.3_In_Frame_Del_p.E812del|KIAA1217_uc001irx.3_In_Frame_Del_p.E812del|KIAA1217_uc001iry.3_In_Frame_Del_p.E812del	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	Homo sapiens KIAA1217 (KIAA1217), transcript variant 1, mRNA.	1129					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGATGAGGAGGAAGAAGAAGAAG	0.552													---	385	---	---	7	---					
ANK3	288	broad.mit.edu	37	10	61828745	61828747	+	In_Frame_Del	DEL	GTG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:61828745_61828747delGTG	uc001jky.3	-	36	12230_12232	c.11892_11894delCAC	c.(11890-11895)accact>act	p.3964_3965TT>T	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	3964	Thr-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ggtggtggcagtggtggtggtgg	0.498													---	576	---	---	8	---					
ZMIZ1	57178	broad.mit.edu	37	10	81072446	81072446	+	Frame_Shift_Del	DEL	C	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:81072446delC	uc001kaf.2	+	24	3716	c.3144delC	c.(3142-3144)gacfs	p.D1048fs	ZMIZ1_uc001kag.2_Frame_Shift_Del_p.D924fs|ZMIZ1_uc010qlq.1_Frame_Shift_Del_p.D114fs	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	Homo sapiens zinc finger, MIZ-type containing 1 (ZMIZ1), mRNA.	1048					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CTTATCTGGACCCCCCCGACC	0.557													---	1386	---	---	7	---					
TNKS2	80351	broad.mit.edu	37	10	93601945	93601946	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr10:93601945_93601946insA	uc001khp.3	+	15	2153_2154	c.1856_1857insA	c.(1855-1857)acafs	p.T619fs		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	Homo sapiens tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 (TNKS2), mRNA.	619					Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding	p.N622fs*29(1)		biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				GCAGACCCTACAAAAAAAAACA	0.391													---	301	---	---	15	---					
SPON1	10418	broad.mit.edu	37	11	14276276	14276277	+	Splice_Site	DEL	GT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:14276276_14276277delGT	uc001mle.3	+	9	1357	c.1089_splice	c.e9+1	p.E363_splice		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	Homo sapiens spondin 1, extracellular matrix protein (SPON1), mRNA.	364	Spondin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GACCTATGAGGTGTGTGTGTGT	0.594													---	258	---	---	12	---					
PLEKHA7	144100	broad.mit.edu	37	11	16822525	16822525	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:16822525delA	uc010rcu.1	-	16	2420	c.2405delT	c.(2404-2406)ttcfs	p.F802fs	PLEKHA7_uc001mmo.3_Frame_Shift_Del_p.F802fs|PLEKHA7_uc010rcv.2_Frame_Shift_Del_p.F376fs|PLEKHA7_uc001mmn.3_Frame_Shift_Del_p.F510fs	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	Homo sapiens pleckstrin homology domain containing, family A member 7 (PLEKHA7), mRNA.	802					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						GGTCACCTGGAAAAAAAAGGC	0.443													---	870	---	---	7	---					
MUC15	143662	broad.mit.edu	37	11	26587427	26587427	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:26587427delT	uc001mqw.3	-	2	333	c.60delA	c.(58-60)aaafs	p.K20fs	ANO3_uc010rdr.2_Intron|ANO3_uc001mqt.4_Intron|ANO3_uc010rds.2_Intron|ANO3_uc010rdt.2_Intron|MUC15_uc001mqx.3_5'UTR|MUC15_uc001mqy.3_Frame_Shift_Del_p.K20fs	NM_001135091	NP_663625	Q8N387	MUC15_HUMAN	Homo sapiens mucin 15, cell surface associated (MUC15), transcript variant 1, mRNA.	0						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						TTGGTATTGGTTTTTTTTTAA	0.289													---	313	---	---	7	---					
SLC22A9	114571	broad.mit.edu	37	11	63149668	63149669	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:63149668_63149669insA	uc001nww.3	+	5	1260_1261	c.992_993insA	c.(991-993)gcafs	p.A331fs	SLC22A9_uc001nwx.3_Non-coding_Transcript	NM_080866	NP_543142	Q8IVM8	S22A9_HUMAN	Homo sapiens solute carrier family 22 (organic anion transporter), member 9 (SLC22A9), mRNA.	331					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						CTGGAGGCAGCACAAAAAAAAA	0.406													---	813	---	---	8	---					
FAU	2197	broad.mit.edu	37	11	64888248	64888250	+	In_Frame_Del	DEL	TCT	-	-	rs1065065		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:64888248_64888250delTCT	uc001ocx.3	-	4	424_426	c.305_307delAGA	c.(304-309)aagaca>aca	p.K102del	MRPL49_uc021qle.1_5'Flank|MRPL49_uc001oda.2_5'Flank|MRPL49_uc021qlf.1_5'Flank	NM_001997	NP_001988	P35544	UBIM_HUMAN	Homo sapiens Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (FAU), mRNA.	0								p.K101K(1)		NS(3)|kidney(1)|large_intestine(2)	6						GCCCGACCTGTCTTCTTCTTCTT	0.542													---	772	---	---	9	---					
NOX4	50507	broad.mit.edu	37	11	89106662	89106663	+	Splice_Site	INS	-	A	A	rs56022003		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:89106662_89106663insA	uc001pct.3	-	12	1314	c.1075_splice	c.e12-1	p.C359_splice	NOX4_uc009yvr.3_Splice_Site_p.C334_splice|NOX4_uc001pcu.3_Splice_Site_p.C285_splice|NOX4_uc001pcw.3_Splice_Site_p.C52_splice|NOX4_uc001pcx.3_Splice_Site_p.C52_splice|NOX4_uc001pcv.3_Splice_Site_p.C359_splice|NOX4_uc009yvo.3_Splice_Site|NOX4_uc010rtu.2_Splice_Site_p.C193_splice|NOX4_uc009yvp.3_Intron|NOX4_uc010rtv.2_Splice_Site_p.C335_splice|NOX4_uc009yvq.3_Splice_Site_p.C335_splice	NM_016931	NP_001137309	Q9NPH5	NOX4_HUMAN	Homo sapiens NADPH oxidase 4 (NOX4), transcript variant 1, mRNA.	359	FAD-binding FR-type.|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	NAD(P)H oxidase activity|electron carrier activity|flavin adenine dinucleotide binding|heme binding|nucleotide binding|oxygen sensor activity	p.?(1)		NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AGTTGGACACTAAAAAAAAATA	0.292													---	707	---	---	7	---					
DDX10	1662	broad.mit.edu	37	11	108559769	108559769	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:108559769delT	uc001pkm.3	+	6	1020	c.955delT	c.(955-957)tttfs	p.F319fs	DDX10_uc001pkl.1_Frame_Shift_Del_p.F319fs	NM_004398	NP_004389	Q13206	DDX10_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 (DDX10), mRNA.	319	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		GAGCATTGTATTTTTTTCCAG	0.353			T	NUP98	AML*								---	1619	---	---	9	---					
CADM1	23705	broad.mit.edu	37	11	115080312	115080314	+	In_Frame_Del	DEL	TGG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr11:115080312_115080314delTGG	uc001ppi.4	-	7	1187_1189	c.1058_1060delCCA	c.(1057-1062)accatc>atc	p.T353del	CADM1_uc001ppf.4_Intron|CADM1_uc001ppk.4_Intron|CADM1_uc001ppj.4_Intron|CADM1_uc001pph.4_In_Frame_Del_p.T105del	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	Homo sapiens cell adhesion molecule 1 (CADM1), transcript variant 1, mRNA.	353				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		atggtaaggatggtggtggtggt	0.429													---	352	---	---	10	---					
KDM5A	5927	broad.mit.edu	37	12	416952	416953	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:416952_416953insT	uc001qif.1	-	22	3960_3961	c.3597_3598insA	c.(3595-3600)aaaggafs	p.K1199fs		NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	Homo sapiens lysine (K)-specific demethylase 5A (KDM5A), mRNA.	1199					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						CAGCTGGATCCTTTTTTTTGGG	0.475			T	NUP98	AML								---	648	---	---	9	---					
CD163L1	283316	broad.mit.edu	37	12	7556270	7556270	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:7556270delT	uc010sge.2	-	5	1325	c.1299delA	c.(1297-1299)aaafs	p.K433fs	CD163L1_uc001qsy.3_Frame_Shift_Del_p.K423fs	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	Homo sapiens CD163 molecule-like 1 (CD163L1), mRNA.	423	SRCR 4.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CATTACTAGGTTTAGCACGAC	0.458													---	804	---	---	7	---					
TAS2R50	259296	broad.mit.edu	37	12	11139432	11139432	+	Frame_Shift_Del	DEL	A	-	-	rs79147066		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:11139432delA	uc001qzl.2	-	0	80	c.28delT	c.(28-30)tcafs	p.S10fs	PRH1_uc001qzb.4_Intron|TAS2R14_uc021qve.1_Intron|PRH1_uc021qvg.1_Intron|PRB4_uc001qzf.1_Intron|TAS2R14_uc001qzj.3_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	Homo sapiens taste receptor, type 2, member 50 (TAS2R50), mRNA.	10					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.S10fs*3(4)|p.S10fs*25(2)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						ATTAGAATTGAAAAAAAAATG	0.318													---	293	---	---	7	---					
SCAF11	9169	broad.mit.edu	37	12	46320707	46320708	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:46320707_46320708delTC	uc001rox.3	-	10	3063_3064	c.2776_2777delGA	c.(2776-2778)gaafs	p.E926fs	SCAF11_uc001row.3_Frame_Shift_Del_p.E611fs|SCAF11_uc001roy.1_Frame_Shift_Del_p.E1000fs	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	Homo sapiens SR-related CTD-associated factor 11 (SCAF11), mRNA.	926	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GGTTCTCCTTTCTCTCTCTCTC	0.446													---	975	---	---	16	---					
TMBIM4	51643	broad.mit.edu	37	12	66531936	66531937	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:66531936_66531937insA	uc009zqr.3	-	7	737_738	c.661_662insT	c.(661-663)tatfs	p.Y221fs	LLPH_uc010ssx.2_Intron|TMBIM4_uc001stc.3_Frame_Shift_Ins_p.Y174fs|TMBIM4_uc001std.3_Frame_Shift_Ins_p.Y143fs|TMBIM4_uc001stf.3_Frame_Shift_Ins_p.L162fs|TMBIM4_uc009zqs.3_Frame_Shift_Ins_p.F158fs	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	Homo sapiens transmembrane BAX inhibitor motif containing 4 (TMBIM4), mRNA.	174						integral to membrane	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|ovary(1)|prostate(2)	9				GBM - Glioblastoma multiforme(28;0.0745)		TATCTCACTATAAAAAAAAAAC	0.351													---	235	---	---	8	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:72094757delT	uc001sws.3	+	5	1576	c.993delT	c.(991-993)ggtfs	p.G331fs		NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	Homo sapiens transmembrane protein 19 (TMEM19), mRNA.	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													---	943	---	---	8	---					
TMPO	7112	broad.mit.edu	37	12	98921671	98921672	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:98921671_98921672insA	uc001tfh.2	+	1	582_583	c.287_288insA	c.(286-288)acafs	p.T96fs	TMPO_uc001tfi.2_Frame_Shift_Ins_p.T96fs|TMPO_uc001tfl.3_Non-coding_Transcript|TMPO_uc001tfj.3_Frame_Shift_Ins_p.T96fs|TMPO_uc001tfk.3_Frame_Shift_Ins_p.T96fs	NM_003276	NP_003267	P42167	LAP2B_HUMAN	Homo sapiens thymopoietin (TMPO), transcript variant 1, mRNA.	96	Linker.|Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CAGAAAGCCACAAAAAAAACTG	0.332													---	541	---	---	8	---					
UTP20	27340	broad.mit.edu	37	12	101680156	101680157	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:101680156_101680157insT	uc001tia.1	+	4	540_541	c.384_385insT	c.(382-387)gagtttfs	p.E128fs	UTP20_uc009ztz.1_Frame_Shift_Ins_p.E128fs	NM_014503	NP_055318	O75691	UTP20_HUMAN	Homo sapiens UTP20, small subunit (SSU) processome component, homolog (yeast) (UTP20), mRNA.	128					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						ACTTTCCAGAGTTTTTTTTGAC	0.396													---	1199	---	---	7	---					
C12orf42	374470	broad.mit.edu	37	12	103695960	103695960	+	Frame_Shift_Del	DEL	G	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:103695960delG	uc001tjt.2	-	5	1097	c.1009delC	c.(1009-1011)cgcfs	p.R337fs	C12orf42_uc001tjs.3_Intron|C12orf42_uc009zuf.1_Frame_Shift_Del_p.R337fs|C12orf42_uc001tju.2_Frame_Shift_Del_p.R242fs	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	Homo sapiens chromosome 12 open reading frame 42 (C12orf42), transcript variant 1, mRNA.	337										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						CGGGTTGGGCGGGGGGGTGCT	0.587													---	526	---	---	7	---					
MSI1	4440	broad.mit.edu	37	12	120800902	120800903	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:120800902_120800903insC	uc001tye.1	-	5	409_410	c.345_346insG	c.(343-348)gggctgfs	p.G115fs		NM_002442	NP_002433	O43347	MSI1H_HUMAN	Homo sapiens musashi homolog 1 (Drosophila) (MSI1), mRNA.	115	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCACCGACAGCCCCCCCACAA	0.564													---	909	---	---	7	---					
CLIP1	6249	broad.mit.edu	37	12	122812693	122812694	+	Frame_Shift_Ins	INS	-	T	T	rs77289752		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:122812693_122812694insT	uc001ucg.2	-	16	3204_3205	c.3049_3050insA	c.(3049-3051)acafs	p.T1017fs	CLIP1_uc001uch.1_Frame_Shift_Ins_p.T1006fs|CLIP1_uc001uci.1_Frame_Shift_Ins_p.T971fs|CLIP1_uc001ucj.1_Frame_Shift_Ins_p.T592fs	NM_001247997	NP_001234926	P30622	CLIP1_HUMAN	Homo sapiens CAP-GLY domain containing linker protein 1 (CLIP1), transcript variant 3, mRNA.	1017					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		GTTGTGGCTTGTTTCCATTTTC	0.505													---	802	---	---	8	---					
POLE	5426	broad.mit.edu	37	12	133220099	133220100	+	Frame_Shift_Del	DEL	CA	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr12:133220099_133220100delCA	uc001uks.1	-	33	4381_4382	c.4337_4338delTG	c.(4336-4338)gtgfs	p.V1446fs	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Frame_Shift_Del_p.V250fs|POLE_uc010tbq.1_Non-coding_Transcript|POLE_uc009zyu.1_Frame_Shift_Del_p.V1419fs	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	Homo sapiens polymerase (DNA directed), epsilon (POLE), mRNA.	1446					DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|base-excision repair, gap-filling|nucleotide-excision repair, DNA gap filling|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|chromatin binding|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GTTTATTGACCACACACACACA	0.604								DNA polymerases (catalytic subunits)					---	1244	---	---	21	---					
WASF3	10810	broad.mit.edu	37	13	27250862	27250863	+	Splice_Site	DEL	GT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr13:27250862_27250863delGT	uc001uqv.3	+	7	941	c.716_splice	c.e7+1	p.R239_splice	WASF3_uc001uqw.3_Intron	NM_006646	NP_006637	Q9UPY6	WASF3_HUMAN	Homo sapiens WAS protein family, member 3 (WASF3), mRNA.	239					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CAGATACTAGGTGTGTGTGTGT	0.475													---	482	---	---	8	---					
RBM26	64062	broad.mit.edu	37	13	79918806	79918807	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr13:79918806_79918807insT	uc001vkz.2	-	14	2201_2202	c.2187_2188insA	c.(2185-2190)aaacagfs	p.K729fs	RBM26_uc001vky.2_Frame_Shift_Ins_p.K700fs|RBM26_uc001vla.2_Frame_Shift_Ins_p.K703fs|RBM26_uc001vkx.2_Frame_Shift_Ins_p.K439fs|RBM26_uc010tia.2_Frame_Shift_Ins_p.K84fs	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	Homo sapiens RNA binding motif protein 26 (RBM26), mRNA.	727					mRNA processing		RNA binding|nucleotide binding|protein binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTACTTACCTGTTTTTTTTTCT	0.332													---	257	---	---	7	---					
ACIN1	22985	broad.mit.edu	37	14	23528502	23528503	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr14:23528502_23528503delTC	uc001wit.4	-	18	4208_4209	c.3880_3881delGA	c.(3880-3882)gaafs	p.E1294fs	CDH24_uc001wil.3_5'Flank|CDH24_uc010akf.3_5'Flank|CDH24_uc001win.3_5'Flank|ACIN1_uc001wio.4_Non-coding_Transcript|ACIN1_uc001wip.4_Frame_Shift_Del_p.E536fs|ACIN1_uc001wiq.4_Frame_Shift_Del_p.E536fs|ACIN1_uc001wir.4_Frame_Shift_Del_p.E567fs|ACIN1_uc001wis.4_Frame_Shift_Del_p.E975fs|ACIN1_uc010akg.3_Frame_Shift_Del_p.E1281fs|ACIN1_uc010tnj.2_Frame_Shift_Del_p.E1254fs	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), transcript variant 1, mRNA.	1294	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ccgctccctttctctctctctc	0.629											OREG0022595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	237	---	---	10	---					
IL25	64806	broad.mit.edu	37	14	23845057	23845058	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr14:23845057_23845058delTG	uc001wjr.3	+	1	760_761	c.502_503delTG	c.(502-504)tgtfs	p.C168fs	IL25_uc001wjq.3_Frame_Shift_Del_p.C152fs|CMTM5_uc010akn.3_5'Flank|CMTM5_uc001wju.3_5'Flank|CMTM5_uc010ako.3_5'Flank|CMTM5_uc001wjs.3_5'Flank|CMTM5_uc001wjt.3_5'Flank|CMTM5_uc010akm.3_5'Flank	NM_022789	NP_073626	Q9H293	IL25_HUMAN	Homo sapiens interleukin 25 (IL25), transcript variant 1, mRNA.	168					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TTCCTTAGCTTGTGTGTGTGTG	0.604													---	654	---	---	14	---					
BAZ1A	11177	broad.mit.edu	37	14	35331422	35331423	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr14:35331422_35331423insT	uc001wsk.3	-	2	787_788	c.219_220insA	c.(217-222)aaagcafs	p.K73fs	BAZ1A_uc001wsl.3_Frame_Shift_Ins_p.K73fs|BAZ1A_uc001wsm.1_Frame_Shift_Ins_p.K73fs	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	Homo sapiens bromodomain adjacent to zinc finger domain, 1A (BAZ1A), transcript variant 1, mRNA.	73	Required for association with the CHRAC1/POLE3 complex.|Required for interaction with NCOR1.|WAC.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TTCTGTCTTGCTTTTTTTTCTG	0.426													---	1020	---	---	8	---					
MAX	4149	broad.mit.edu	37	14	65472892	65472892	+	Splice_Site	DEL	G	-	-	rs74781178		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr14:65472892delG	uc001xic.1	-	4	452	c.282_splice	c.e4+1		CHURC1-FNTB_uc010tsl.2_Intron|CHURC1-FNTB_uc010tsm.2_Intron|CHURC1-FNTB_uc001xia.3_Intron	NM_197957	NP_932061	P61244	MAX_HUMAN	Homo sapiens MYC associated factor X (MAX), transcript variant 6, mRNA.						transcription from RNA polymerase II promoter	MLL1 complex|cytoplasm	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		TTTTTTTTTTGCCACCATTTC	0.368													---	543	---	---	25	---					
BTBD7	55727	broad.mit.edu	37	14	93712186	93712188	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr14:93712186_93712188delTGC	uc001ybo.3	-	9	2892_2894	c.2566_2568delGCA	c.(2566-2568)gcadel	p.A856del	BTBD7_uc010aur.3_In_Frame_Del_p.A381del|BTBD7_uc010two.2_In_Frame_Del_p.A676del|BTBD7_uc001ybp.3_In_Frame_Del_p.A505del	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	Homo sapiens BTB (POZ) domain containing 7 (BTBD7), transcript variant 1, mRNA.	856	Poly-Ala.									breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		GCTTCTCAGAtgctgctgctgct	0.537													---	307	---	---	8	---					
FAN1	22909	broad.mit.edu	37	15	31196894	31196894	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr15:31196894delA	uc001zff.3	+	1	319	c.28delA	c.(28-30)aaafs	p.K10fs	FAN1_uc001zfc.3_Frame_Shift_Del_p.K10fs|FAN1_uc010azw.2_Frame_Shift_Del_p.K10fs|FAN1_uc001zfd.3_Frame_Shift_Del_p.K10fs|FAN1_uc001zfe.3_5'UTR	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	Homo sapiens FANCD2/FANCI-associated nuclease 1 (FAN1), transcript variant 1, mRNA.	10					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding			autonomic_ganglia(2)|breast(2)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(6)|lung(8)|skin(1)	29						ACCTCCTGACAAAAAAAGGCC	0.353								Direct reversal of damage					---	743	---	---	13	---					
SRP14	6727	broad.mit.edu	37	15	40328597	40328599	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr15:40328597_40328599delTGC	uc001zkq.2	-	4	418_420	c.346_348delGCA	c.(346-348)gcadel	p.A116del	SRP14_uc001zkr.2_3'UTR|LOC100131089_uc021sjc.1_5'Flank|LOC100131089_uc021sjd.1_5'Flank|LOC100131089_uc021sje.1_5'Flank|LOC100131089_uc001zks.2_5'Flank	NM_003134	NP_003125	P37108	SRP14_HUMAN	Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein) (SRP14), mRNA.	116	Ala/Thr-rich.				SRP-dependent cotranslational protein targeting to membrane|negative regulation of translational elongation|response to drug	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		ctgcggcaggtgctgctgctgct	0.478													---	432	---	---	14	---					
LEO1	123169	broad.mit.edu	37	15	52258134	52258134	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr15:52258134delT	uc002abo.3	-	1	642	c.626delA	c.(625-627)aagfs	p.K209fs	LEO1_uc010bfd.3_Frame_Shift_Del_p.K209fs	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Homo sapiens Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (LEO1), mRNA.	209	Asp-rich.				histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|skin(1)	14				all cancers(107;0.00264)		AGAATTAGCCTTTTCCTCCTC	0.433													---	1662	---	---	7	---					
FAM63B	54629	broad.mit.edu	37	15	59144132	59144134	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr15:59144132_59144134delGCT	uc002afj.3	+	7	1907_1909	c.1705_1707delGCT	c.(1705-1707)gctdel	p.A574del	FAM63B_uc002afi.3_In_Frame_Del_p.A574del|FAM63B_uc002afk.3_Non-coding_Transcript|FAM63B_uc002afl.3_Non-coding_Transcript	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	Homo sapiens family with sequence similarity 63, member B (FAM63B), transcript variant 1, mRNA.	574	Gln-rich.									central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						ACAAGCAGCAGCTGCTGCTGCTG	0.468													---	603	---	---	8	---					
TAOK2	9344	broad.mit.edu	37	16	29994531	29994533	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr16:29994531_29994533delGAG	uc010bzm.2	+	10	1194_1196	c.1159_1161delGAG	c.(1159-1161)gagdel	p.E399del	BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.2_In_Frame_Del_p.E392del|TAOK2_uc021tgf.1_In_Frame_Del_p.E392del|TAOK2_uc002dva.2_In_Frame_Del_p.E392del|TAOK2_uc002dvc.2_In_Frame_Del_p.E392del|TAOK2_uc002dvd.2_In_Frame_Del_p.E219del	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	Homo sapiens TAO kinase 2 (TAOK2), transcript variant 1, mRNA.	392	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CAACgaggaagaggaggaggagg	0.611													---	357	---	---	8	---					
SRCAP	10847	broad.mit.edu	37	16	30736370	30736371	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr16:30736370_30736371insC	uc002dze.1	+	24	6010_6011	c.5625_5626insC	c.(5623-5628)cagcccfs	p.Q1875fs	SRCAP_uc002dzf.3_Non-coding_Transcript|SRCAP_uc002dzg.1_Frame_Shift_Ins_p.Q1670fs	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Homo sapiens Snf2-related CREBBP activator protein (SRCAP), mRNA.	1875	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CTCGACGCCAGCCCCCCCCACC	0.569													---	611	---	---	14	---					
CTRL	1506	broad.mit.edu	37	16	67963919	67963919	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr16:67963919delT	uc002euw.3	-	6	736	c.713delA	c.(712-714)aacfs	p.N238fs		NM_001907	NP_001898	P40313	CTRL_HUMAN	Homo sapiens chymotrypsin-like (CTRL), mRNA.	238	Peptidase S1.				digestion|proteolysis	extracellular space	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|urinary_tract(1)	4		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		CACATTGCAGTTTTTGGTGCC	0.552													---	646	---	---	8	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr16:69782978_69782980delTCC	uc002exs.3	-	5	583_585	c.567_569delGGA	c.(565-570)gaggaa>gaa	p.189_190EE>E		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	Homo sapiens NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) (NOB1), mRNA.	189	Poly-Glu.					nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CCCGTTTTCTTCCTCCTCCTCCT	0.522													---	557	---	---	11	---					
ZFHX3	463	broad.mit.edu	37	16	72822564	72822566	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr16:72822564_72822566delTGC	uc002fck.3	-	9	10282_10284	c.9609_9611delGCA	c.(9607-9612)cagcaa>caa	p.3203_3204QQ>Q	ZFHX3_uc002fcl.3_In_Frame_Del_p.2289_2290QQ>Q	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	3203	Poly-Gln.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cacctgtggttgctgctgctgct	0.650													---	672	---	---	18	---					
BC139719	0	broad.mit.edu	37	16	90161003	90161004	+	Frame_Shift_Ins	INS	-	GG	GG	rs142805492	by1000genomes	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr16:90161003_90161004insGG	uc002fqq.3	+	2	233_234	c.233_234insGG	c.(232-234)tcgfs	p.S78fs	BC139719_uc002fqp.3_Intron					Homo sapiens, Similar to tubulin, beta, 2, clone IMAGE:4873024, mRNA.																		TCCGTGCGCTCGGGGCCCTTCG	0.673													---	388	---	---	8	---					
WRAP53	55135	broad.mit.edu	37	17	7606714	7606715	+	Frame_Shift_Ins	INS	-	G	G	rs146634933		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:7606714_7606715insG	uc010vuh.2	+	10	1712_1713	c.1557_1558insG	c.(1555-1560)tgtgggfs	p.C519fs	WRAP53_uc010vui.2_Frame_Shift_Ins_p.C519fs|WRAP53_uc002gip.3_Frame_Shift_Ins_p.C519fs|WRAP53_uc002gir.3_Frame_Shift_Ins_p.C519fs|WRAP53_uc002giq.3_Non-coding_Transcript|WRAP53_uc010cnl.3_Frame_Shift_Ins_p.C486fs|EFNB3_uc002gis.3_5'Flank	NM_001143990	NP_060551	Q9BUR4	WAP53_HUMAN	Homo sapiens WD repeat containing, antisense to TP53 (WRAP53), transcript variant 2, mRNA.	519					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	RNA binding|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						TCTGGTGGTGTGGGGGGGCGCC	0.599													---	358	---	---	7	---					
TRPV2	51393	broad.mit.edu	37	17	16335490	16335492	+	In_Frame_Del	DEL	TGC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:16335490_16335492delTGC	uc002gpy.3	+	11	2264_2266	c.1865_1867delTGC	c.(1864-1869)gtgctg>gtg	p.L627del	TRPV2_uc002gpz.3_In_Frame_Del_p.L197del	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily V, member 2 (TRPV2), mRNA.	627					sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CGCGGCATGGTGCTGCTGCTGCT	0.596													---	383	---	---	15	---					
DHRS7B	25979	broad.mit.edu	37	17	21094331	21094333	+	In_Frame_Del	DEL	GAA	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:21094331_21094333delGAA	uc002gyo.3	+	6	887_889	c.843_845delGAA	c.(841-846)gggaag>ggg	p.K285del		NM_015510	NP_056325	Q6IAN0	DRS7B_HUMAN	Homo sapiens dehydrogenase/reductase (SDR family) member 7B (DHRS7B), mRNA.	285						integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|pancreas(2)	7						CTGCTGTGGGGAAGAAGAAGAAA	0.507													---	911	---	---	9	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	Splice_Site	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	-	rs483929	by1000genomes	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	uc002hwe.4	-	2	287	c.246_splice	c.e2-1	p.S82_splice		NM_033060	NP_149049	Q9BYQ7	KRA41_HUMAN	Homo sapiens keratin associated protein 4-1 (KRTAP4-1), mRNA.	101	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].					keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													---	369	---	---	14	---					
CCDC43	124808	broad.mit.edu	37	17	42756252	42756253	+	Frame_Shift_Ins	INS	-	T	T			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:42756252_42756253insT	uc002ihc.2	-	4	690_691	c.646_647insA	c.(646-648)aggfs	p.R216fs	CCDC43_uc021tye.1_Non-coding_Transcript|CCDC43_uc010czw.1_3'UTR	NM_144609	NP_653210	Q96MW1	CCD43_HUMAN	Homo sapiens coiled-coil domain containing 43 (CCDC43), transcript variant 1, mRNA.	216										lung(2)	2		Prostate(33;0.0322)				TCTCTGTGTCCTTTTTTTTTCC	0.465													---	180	---	---	7	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:45219612delA	uc002ile.4	-	10	1506	c.1379delT	c.(1378-1380)ctafs	p.L460fs	CDC27_uc002ild.4_Frame_Shift_Del_p.L454fs|CDC27_uc002ilf.4_Frame_Shift_Del_p.L454fs|CDC27_uc010wkp.2_Frame_Shift_Del_p.L393fs|CDC27_uc010wkq.1_Intron	NM_001114091	NP_001107563	P30260	CDC27_HUMAN	Homo sapiens cell division cycle 27 homolog (S. cerevisiae) (CDC27), transcript variant 1, mRNA.	454				Missing (in Ref. 1; AAA60471).	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													---	167	---	---	16	---					
PRR11	55771	broad.mit.edu	37	17	57247170	57247171	+	Frame_Shift_Ins	INS	-	A	A			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr17:57247170_57247171insA	uc002ixf.2	+	1	369_370	c.57_58insA	c.(55-60)ttcaaafs	p.F19fs	PRR11_uc021uar.1_Non-coding_Transcript	NM_018304	NP_060774	Q96HE9	PRR11_HUMAN	Homo sapiens proline rich 11 (PRR11), mRNA.	19								p.E23fs*9(3)|p.E23fs*46(1)		breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|pancreas(1)	16	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AAAGATTATTCAAAAAAAAAGA	0.361													---	439	---	---	11	---					
ADNP2	22850	broad.mit.edu	37	18	77894260	77894261	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr18:77894260_77894261insC	uc002lnw.3	+	3	1419_1420	c.964_965insC	c.(964-966)tccfs	p.S322fs		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	Homo sapiens ADNP homeobox 2 (ADNP2), mRNA.	322	Pro-rich.				cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A325fs*59(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|liver(1)|lung(15)|ovary(5)|prostate(2)	42		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CCTCACTCATTCCCCCCCTGCT	0.644													---	441	---	---	8	---					
TNFSF9	8744	broad.mit.edu	37	19	6531149	6531151	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:6531149_6531151delGCT	uc002mfh.2	+	0	140_142	c.102_104delGCT	c.(100-105)gggctg>ggg	p.L41del		NM_003811	NP_003802	P41273	TNFL9_HUMAN	Homo sapiens tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9), mRNA.	41	Poly-Leu.				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						TGGTCGCGGGgctgctgctgctg	0.768													---	199	---	---	7	---					
RETN	56729	broad.mit.edu	37	19	7734228	7734230	+	In_Frame_Del	DEL	CTC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:7734228_7734230delCTC	uc002mhg.1	+	1	53_55	c.16_18delCTC	c.(16-18)ctcdel	p.L9del	RETN_uc002mhf.1_In_Frame_Del_p.L9del|RETN_uc010dvm.1_Non-coding_Transcript	NM_001193374	NP_065148	Q9HD89	RETN_HUMAN	Homo sapiens resistin (RETN), transcript variant 2, mRNA.	9							hormone activity			ovary(1)	1						AGCTCTCTGTCTCCTCCTCCTCC	0.596													---	969	---	---	9	---					
ZNF626	199777	broad.mit.edu	37	19	20808338	20808338	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:20808338delT	uc002npb.1	-	3	495	c.345delA	c.(343-345)aaafs	p.K115fs	ZNF626_uc002npc.1_Frame_Shift_Del_p.K39fs	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	Homo sapiens zinc finger protein 626 (ZNF626), transcript variant 1, mRNA.	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						TTATACATCCTTTTTTTAACT	0.353													---	637	---	---	7	---					
SPRED3	399473	broad.mit.edu	37	19	38882864	38882866	+	In_Frame_Del	DEL	CCT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:38882864_38882866delCCT	uc002oim.3	+	2	363_365	c.359_361delCCT	c.(358-363)ccctcc>ccc	p.S128del	SPRED3_uc002oil.1_In_Frame_Del_p.S128del	NM_001042522	NP_001035987	Q2MJR0	SPRE3_HUMAN	Homo sapiens sprouty-related, EVH1 domain containing 3 (SPRED3), transcript variant 1, mRNA.	128	Ser-rich.				multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCACTCAccccctcctcctcctc	0.645													---	87	---	---	7	---					
RYR1	6261	broad.mit.edu	37	19	38948159	38948160	+	Frame_Shift_Del	DEL	TG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:38948159_38948160delTG	uc002oit.3	+	16	1944_1945	c.1814_1815delTG	c.(1813-1815)ctgfs	p.L605fs	RYR1_uc002oiu.3_Frame_Shift_Del_p.L605fs	NM_000540	NP_000531	P21817	RYR1_HUMAN	Homo sapiens ryanodine receptor 1 (skeletal) (RYR1), transcript variant 1, mRNA.	605	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	I band|cell cortex|cytosol|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTATGCTCCCTGTGTGTGTGTA	0.530													---	1177	---	---	8	---					
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	-	-	rs62639328	byFrequency	TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:46299165_46299167delCCT	uc002pdm.3	-	5	2285_2287	c.2114_2116delAGG	c.(2113-2118)gagggc>ggc	p.E705del	RSPH6A_uc002pdl.3_In_Frame_Del_p.E441del	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	Homo sapiens radial spoke head 6 homolog A (Chlamydomonas) (RSPH6A), mRNA.	705	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tcctcctcgccctcctcctcctc	0.586													---	818	---	---	8	---					
FUZ	80199	broad.mit.edu	37	19	50310483	50310485	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:50310483_50310485delCAG	uc002ppq.2	-	10	1384_1386	c.1180_1182delCTG	c.(1180-1182)ctgdel	p.L394del	FUZ_uc002ppt.2_Non-coding_Transcript|FUZ_uc002ppu.2_In_Frame_Del_p.L358del	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	Homo sapiens fuzzy homolog (Drosophila) (FUZ), transcript variant 1, mRNA.	394	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TCTGGGGAGACAGCAGCAGCAGC	0.635													---	303	---	---	13	---					
ZNF416	55659	broad.mit.edu	37	19	58084579	58084579	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr19:58084579delA	uc002qpf.3	-	3	864	c.693delT	c.(691-693)tttfs	p.F231fs		NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	Homo sapiens zinc finger protein 416 (ZNF416), mRNA.	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		CTCTAGGGTGAAAAAAAGTGT	0.453													---	1177	---	---	7	---					
FRG1B	284802	broad.mit.edu	37	20	29628310	29628312	+	In_Frame_Del	DEL	AGG	-	-	rs111939959		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr20:29628310_29628312delAGG	uc010ztl.1	+	2	254_256	c.222_224delAGG	c.(220-225)gcagga>gca	p.G75del	FRG1B_uc002wvm.1_Non-coding_Transcript|FRG1B_uc010ztj.1_Non-coding_Transcript|FRG1B_uc010gdr.1_Non-coding_Transcript|FRG1B_uc010ztk.1_In_Frame_Del_p.G27del					Homo sapiens FSHD region gene 1 family, member B (FRG1B), non-coding RNA.											endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTAAAACAGCAGGAGAAGAAGAA	0.355													---	668	---	---	7	---					
BCL2L1	598	broad.mit.edu	37	20	30309591	30309591	+	Frame_Shift_Del	DEL	A	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr20:30309591delA	uc002wwl.3	-	1	797	c.431delT	c.(430-432)ttcfs	p.F144fs	BCL2L1_uc002wwk.3_Non-coding_Transcript|BCL2L1_uc002wwm.3_Intron|BCL2L1_uc002wwn.3_Frame_Shift_Del_p.F144fs|BCL2L1_uc002wwo.1_Frame_Shift_Del_p.F144fs	NM_138578	NP_612815	Q07817	B2CL1_HUMAN	Homo sapiens BCL2-like 1 (BCL2L1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	144					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			GCCGAAGGAGAAAAAGGCCAC	0.542													---	1603	---	---	9	---					
CTCFL	140690	broad.mit.edu	37	20	56099187	56099187	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr20:56099187delT	uc010giw.1	-	1	186	c.75delA	c.(73-75)aaafs	p.K25fs	CTCFL_uc010gix.1_Frame_Shift_Del_p.K25fs|CTCFL_uc002xym.2_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjb.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gja.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjc.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjd.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gje.3_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjg.3_Intron|CTCFL_uc010gjf.3_Intron|CTCFL_uc010gjh.2_Frame_Shift_Del_p.K25fs|CTCFL_uc010gji.2_Intron|CTCFL_uc010gjj.2_Frame_Shift_Del_p.K25fs|CTCFL_uc021wfe.1_Frame_Shift_Del_p.K25fs|CTCFL_uc021wff.1_Intron|CTCFL_uc021wfg.1_Intron|CTCFL_uc010gjk.1_Frame_Shift_Del_p.K25fs|CTCFL_uc010gjl.1_Frame_Shift_Del_p.K25fs	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	Homo sapiens CCCTC-binding factor (zinc finger protein)-like (CTCFL), mRNA.	25					DNA methylation involved in gamete generation|cell cycle|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CCTTCAGGCCTTTTTCCGGCA	0.502													---	1766	---	---	9	---					
SCAF4	57466	broad.mit.edu	37	21	33044257	33044259	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr21:33044257_33044259delGCT	uc002ypd.2	-	19	3323_3325	c.2897_2899delAGC	c.(2896-2901)cagcca>cca	p.Q966del	SCAF4_uc002ype.2_In_Frame_Del_p.Q944del|SCAF4_uc010glu.2_In_Frame_Del_p.Q951del	NM_020706	NP_065757	O95104	SFR15_HUMAN	Homo sapiens SR-related CTD-associated factor 4 (SCAF4), transcript variant 1, mRNA.	966	Poly-Gln.					nucleus	RNA binding|nucleotide binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GATGGTGgtggctgctgctgctg	0.581													---	616	---	---	24	---					
KRTAP10-6	386674	broad.mit.edu	37	21	46012219	46012220	+	In_Frame_Ins	INS	-	GGGGCGCAGCAGCTG	GGGGCGCAGCAGCTG	rs71199613		TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr21:46012219_46012220insGGGGCGCAGCAGCTG	uc002zfm.3	-	0	167_168	c.146_147insCAGCTGCTGCGCCCC	c.(145-147)ccg>ccCAGCTGCTGCGCCCCg	p.49_49P>PSCCAP	TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198688	NP_941961	P60371	KR106_HUMAN	Homo sapiens keratin associated protein 10-6 (KRTAP10-6), mRNA.	49	29 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						GGCAGGGGGCCGGGGCGCAGCA	0.688													---	287	---	---	7	---					
CCT8L2	150160	broad.mit.edu	37	22	17071787	17071787	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr22:17071787delT	uc002zlp.1	-	0	1914	c.1654delA	c.(1654-1656)atcfs	p.I552fs		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	Homo sapiens chaperonin containing TCP1, subunit 8 (theta)-like 2 (CCT8L2), mRNA.	552					cellular protein metabolic process	cytoplasm	ATP binding|anion channel activity|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AATCCAAGGATTTTTTTTGTT	0.408													---	617	---	---	7	---					
MED15	51586	broad.mit.edu	37	22	20918817	20918819	+	In_Frame_Del	DEL	CAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr22:20918817_20918819delCAG	uc002zsp.3	+	5	612_614	c.532_534delCAG	c.(532-534)cagdel	p.Q188del	MED15_uc002zsn.1_In_Frame_Del_p.Q107del|MED15_uc002zso.2_In_Frame_Del_p.Q117del|MED15_uc002zsq.3_In_Frame_Del_p.Q188del|MED15_uc010gso.3_In_Frame_Del_p.Q188del|MED15_uc002zsr.3_In_Frame_Del_p.Q162del|MED15_uc011ahs.2_In_Frame_Del_p.Q162del|MED15_uc011aht.1_In_Frame_Del_p.Q162del|MED15_uc002zss.3_In_Frame_Del_p.Q107del|MED15_uc011ahu.2_5'Flank	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	Homo sapiens mediator complex subunit 15 (MED15), transcript variant 1, mRNA.	188	Poly-Gln.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			ggcggcgctacagcagcagcagc	0.626											OREG0026319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	124	---	---	7	---					
C22orf43	51233	broad.mit.edu	37	22	23959767	23959769	+	In_Frame_Del	DEL	CAT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr22:23959767_23959769delCAT	uc002zxf.3	-	6	810_812	c.512_514delATG	c.(511-516)gatgcc>gcc	p.D171del		NM_016449	NP_057533	Q6PGQ1	CV043_HUMAN	Homo sapiens chromosome 22 open reading frame 43 (C22orf43), mRNA.	171	Asp-rich.									endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)	11						CTTACCTGGGcatcatcatcatc	0.433													---	379	---	---	9	---					
TRIOBP	11078	broad.mit.edu	37	22	38120029	38120031	+	In_Frame_Del	DEL	CCT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr22:38120029_38120031delCCT	uc003atr.3	+	6	1737_1739	c.1466_1468delCCT	c.(1465-1470)gcctcc>gcc	p.S491del	TRIOBP_uc003atu.3_In_Frame_Del_p.S319del|TRIOBP_uc003atq.1_In_Frame_Del_p.S491del|TRIOBP_uc003ats.1_In_Frame_Del_p.S319del	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	Homo sapiens TRIO and F-actin binding protein (TRIOBP), transcript variant 6, mRNA.	491					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	GTP-Rho binding|actin binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AATCCCAGAGCCTCCTCTCCCAG	0.601													---	838	---	---	14	---					
RANGAP1	5905	broad.mit.edu	37	22	41650469	41650471	+	In_Frame_Del	DEL	TCC	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr22:41650469_41650471delTCC	uc003azs.3	-	9	2571_2573	c.1101_1103delGGA	c.(1099-1104)gaggaa>gaa	p.367_368EE>E	RANGAP1_uc003azt.3_In_Frame_Del_p.367_368EE>E|RANGAP1_uc003azu.3_In_Frame_Del_p.367_368EE>E|RANGAP1_uc011aoz.2_In_Frame_Del_p.312_313EE>E	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Homo sapiens Ran GTPase activating protein 1 (RANGAP1), mRNA.	367	Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	Ran GTPase activator activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ctcttctccttcctcctcctcct	0.562													---	689	---	---	9	---					
BIK	638	broad.mit.edu	37	22	43525245	43525247	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr22:43525245_43525247delGCT	uc003bdk.3	+	4	480_482	c.417_419delGCT	c.(415-420)gcgctg>gcg	p.L144del		NM_001197	NP_001188	Q13323	BIK_HUMAN	Homo sapiens BCL2-interacting killer (apoptosis-inducing) (BIK), mRNA.	144	Leucine-zipper (Potential).				apoptosis|induction of apoptosis|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	endomembrane system|integral to membrane				breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|urinary_tract(1)	5		Ovarian(80;0.0694)				tgctgctggcgctgctgctgctg	0.724													---	398	---	---	12	---					
PLXNB2	23654	broad.mit.edu	37	22	50722162	50722163	+	Frame_Shift_Ins	INS	-	C	C			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chr22:50722162_50722163insC	uc003bkv.4	-	14	2531_2532	c.2438_2439insG	c.(2437-2439)ggcfs	p.G813fs	PLXNB2_uc003bkt.1_5'Flank|PLXNB2_uc003bku.1_5'Flank	NM_012401	NP_036533	O15031	PLXB2_HUMAN	Homo sapiens plexin B2 (PLXNB2), mRNA.	813	IPT/TIG 1.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CACCCAGGGGGCCCGTCTCAGG	0.658													---	224	---	---	7	---					
GUCY2F	2986	broad.mit.edu	37	X	108619355	108619355	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrX:108619355delT	uc022cch.1	-	16	3277	c.3192delA	c.(3190-3192)aaafs	p.K1064fs	GUCY2F_uc011msq.2_Non-coding_Transcript|GUCY2F_uc004eod.4_Frame_Shift_Del_p.K1064fs	NM_001522	NP_001513	P51841	GUC2F_HUMAN	Homo sapiens guanylate cyclase 2F, retinal (GUCY2F), mRNA.	1064					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						TCATGAAGCCTTTTTTCCCAA	0.418													---	1354	---	---	10	---					
CUL4B	8450	broad.mit.edu	37	X	119694117	119694119	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrX:119694117_119694119delGAG	uc004esw.3	-	2	866_868	c.429_431delCTC	c.(427-432)tcctca>tca	p.143_144SS>S	CUL4B_uc004esv.3_In_Frame_Del_p.125_126SS>S	NM_003588	NP_003579	Q13620	CUL4B_HUMAN	Homo sapiens cullin 4B (CUL4B), transcript variant 1, mRNA.	143	Ser-rich.				DNA repair|cell cycle|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TGGTGAAGATgaggaggaggagg	0.488													---	439	---	---	9	---					
HTATSF1	27336	broad.mit.edu	37	X	135585048	135585050	+	In_Frame_Del	DEL	AAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrX:135585048_135585050delAAG	uc004ezw.3	+	5	1104_1106	c.682_684delAAG	c.(682-684)aagdel	p.K232del	HTATSF1_uc004ezx.3_In_Frame_Del_p.K232del	NM_001163280	NP_055315	O43719	HTSF1_HUMAN	Homo sapiens HIV-1 Tat specific factor 1 (HTATSF1), transcript variant 1, mRNA.	232	Poly-Lys.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	RNA binding|nucleotide binding|protein binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					TGATGCCTCAAAGAAGAAGAAGA	0.335													---	654	---	---	7	---					
MAGEC1	9947	broad.mit.edu	37	X	140996449	140996449	+	Frame_Shift_Del	DEL	T	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrX:140996449delT	uc004fbt.3	+	3	3583	c.3259delT	c.(3259-3261)tttfs	p.F1087fs	MAGEC1_uc010nsl.2_Frame_Shift_Del_p.F154fs|MAGEC1_uc022cfi.1_Frame_Shift_Del_p.F746fs	NM_005462	NP_005453	O60732	MAGC1_HUMAN	Homo sapiens melanoma antigen family C, 1 (MAGEC1), mRNA.	1087	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AGTAGTAGAGTTTTTGGCCAT	0.468										HNSCC(15;0.026)			---	1277	---	---	7	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrX:150817142_150817144delGCT	uc004fev.4	+	8	1017_1019	c.685_687delGCT	c.(685-687)gctdel	p.A236del		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	Homo sapiens PAS domain containing 1 (PASD1), mRNA.	236	Poly-Ala.					nucleus	signal transducer activity	p.A229A(2)|p.A235D(1)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.433													---	784	---	---	12	---					
ZNF185	7739	broad.mit.edu	37	X	152087570	152087572	+	In_Frame_Del	DEL	GAG	-	-			TCGA-HZ-7924-01A-11D-2154-08	TCGA-HZ-7924-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c4c1f4b1-d515-4a44-a975-38fa092bca24	cbb96d11-05d7-46a3-ace3-0b6010d95fb2	g.chrX:152087570_152087572delGAG	uc011myg.2	+	6	523_525	c.475_477delGAG	c.(475-477)gagdel	p.E165del	ZNF185_uc011myi.2_In_Frame_Del_p.E165del|ZNF185_uc011myj.2_In_Frame_Del_p.E165del|ZNF185_uc011myh.2_In_Frame_Del_p.E165del|ZNF185_uc011myk.2_In_Frame_Del_p.E165del|ZNF185_uc010ntv.2_In_Frame_Del_p.E165del|ZNF185_uc004fgw.4_In_Frame_Del_p.E30del|ZNF185_uc004fgu.3_5'UTR|ZNF185_uc004fgv.3_5'Flank	NM_001178106	NP_001171577	O15231	ZN185_HUMAN	Homo sapiens zinc finger protein 185 (LIM domain) (ZNF185), transcript variant 1, mRNA.	165	Poly-Glu.					cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGACACCgaggaggaggagg	0.596													---	158	---	---	7	---					
