Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HLA-G	3135	broad.mit.edu	37	6	29855969	29855969	+	Missense_Mutation	SNP	T	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:29855969T>C	uc010jro.3	+	1	463	c.317T>C	c.(316-318)aTc>aCc	p.I106T	HLA-G_uc021ytw.1_Intron|HLA-G_uc011dmb.2_Intron|HLA-J_uc021yty.1_5'Flank|HLA-G_uc021ytv.1_Intron|HLA-J_uc021ytx.1_5'Flank			P17693	HLAG_HUMAN	Homo sapiens major histocompatibility complex, class I, H (pseudogene) (HLA-H), non-coding RNA.	104	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to membrane	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						AACCTGCGGATCGCGCTCCGC	0.697000														99			5		0	0	0.093190	0	0
ZNF492	57615	broad.mit.edu	37	19	22817127	22817127	+	Splice_Site	SNP	T	G	G			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:22817127T>G	uc002nqw.3	+	1	1	c.-243_splice	c.e1-1			NM_020855	NP_065906	Q9P255	ZN492_HUMAN	Homo sapiens zinc finger protein 492 (ZNF492), mRNA.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TGTGGCGGGGTCTTTGTCTCT	0.597000														64			21		0	0	0.153744	0	0
FAM182B	728882	broad.mit.edu	37	20	25848629	25848629	+	RNA	SNP	C	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr20:25848629C>T	uc002wvd.1	-	0		c.158G>A								Homo sapiens family with sequence similarity 182, member B (FAM182B), non-coding RNA.											lung(1)	1						gctgggatgccgtgctgcttc	0.667000														30			4		0	0	0.248553	0	0
EFCAB6	64800	broad.mit.edu	37	22	44083353	44083353	+	Missense_Mutation	SNP	A	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr22:44083353A>T	uc003bdy.2	-	10	1454	c.1140T>A	c.(1138-1140)aaT>aaA	p.N380K	EFCAB6_uc003bdz.2_Missense_Mutation_p.N228K|EFCAB6_uc010gzi.2_Missense_Mutation_p.N228K|EFCAB6_uc010gzk.1_Intron|EFCAB6_uc011aqa.2_Intron|EFCAB6_uc003bea.2_Missense_Mutation_p.N377K	NM_022785	NP_942153	Q5THR3	EFCB6_HUMAN	Homo sapiens EF-hand calcium binding domain 6 (EFCAB6), transcript variant 1, mRNA.	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding	p.N380K(2)		breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TTACATACCTATTTCTTTTTG	0.299000														123			23		0	0	0.353513	0	0
DDX12P	440081	broad.mit.edu	37	12	9572801	9572801	+	RNA	SNP	C	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:9572801C>T	uc021qut.1	-	11		c.2338G>A			DDX12P_uc001qvx.4_Non-coding_Transcript|DDX12P_uc001qvy.1_5'Flank					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene (DDX12P), non-coding RNA.									p.A751A(2)									ACCTGGAATACGCCAGCAGCA	0.557000														79			5		0	0	0.217242	0	0
ZNF320	162967	broad.mit.edu	37	19	53367338	53367338	+	RNA	SNP	G	A	A	rs4803014	by1000genomes	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:53367338G>A	uc010eqi.1	-	5		c.535C>T						A2RRD8	ZN320_HUMAN	Homo sapiens zinc finger protein 320 (ZNF320), mRNA.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(4)|large_intestine(5)|liver(1)|lung(10)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(134;0.0534)		TGTATAAAGCGTTCTGTGCAG	0.448000														276			10		0	0	0.069234	0	0
ZNF98	148198	broad.mit.edu	37	19	22605147	22605147	+	Splice_Site	SNP	A	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:22605147A>C	uc002nqt.2	-	1	1	c.-121_splice	c.e1-1			NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	Homo sapiens zinc finger protein 98 (ZNF98), mRNA.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				AGAGACAAAGACCCCGCCACA	0.607000														83			31		0	0	0.323286	0	0
KIR2DL5B	553128	broad.mit.edu	37	GL000209.1	86765	86765	+	Missense_Mutation	SNP	G	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrGL000209.1:86765G>T	uc002quk.1	+	0	75	c.20G>T	c.(19-21)aGc>aTc	p.S7I	KIR2DL2_uc002qtt.2_Intron|KIR2DL2_uc002qty.3_Intron|KIR2DL2_uc021vdb.1_Intron|KIR2DL2_uc010yie.2_Intron	NM_001018081	NP_001018091	Q8NHK4	Q8NHK4_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5B (KIR2DL5B), mRNA.	7							receptor activity										ATGGTCATCAGCATGGCGTGT	0.617000														60			5		5.18039e-06	5.64293e-06	0.278610	1	0
AK308867	0	broad.mit.edu	37	16	70268158	70268158	+	RNA	SNP	A	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr16:70268158A>C	uc010cfp.1	-	2		c.257T>G								Homo sapiens cDNA, FLJ98908.																		TTCTTCATTAAAACAGCTACT	0.333000														57			4		0	0	0.150653	0	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	Missense_Mutation	SNP	T	G	G			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr16:32890622T>G	uc002edh.1	-	4	440	c.264A>C	c.(262-264)aaA>aaC	p.K88N	SLC6A10P_uc002edi.1_Non-coding_Transcript					Homo sapiens solute carrier family 6 (neurotransmitter transporter, creatine), member 10, pseudogene (SLC6A10P), non-coding RNA.																		CGTTGGTGTTTTTGTAGACCA	0.617000														115			5		0	0	0.248553	0	0
DDX11L11	0	broad.mit.edu	37	12	92040	92040	+	Nonsense_Mutation	SNP	G	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:92040G>T	uc010sdi.1	-	1	298	c.270C>A	c.(268-270)tgC>tgA	p.C90*	DDX11L11_uc010sdj.1_Non-coding_Transcript					SubName: Full=DEAD/H box polypeptide 11 like 11;																		CACCTTTGTAGCAGGATCCCT	0.587000														95			16		0.000308642	0.000319104	0.132662	1	0
HLA-G	3135	broad.mit.edu	37	6	29855999	29855999	+	Missense_Mutation	SNP	G	C	C	rs113415054	by1000genomes	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:29855999G>C	uc010jro.3	+	1	493	c.347G>C	c.(346-348)gGc>gCc	p.G116A	HLA-G_uc021ytw.1_Intron|HLA-G_uc011dmb.2_Intron|HLA-J_uc021yty.1_5'Flank|HLA-G_uc021ytv.1_Intron|HLA-J_uc021ytx.1_5'Flank			P17693	HLAG_HUMAN	Homo sapiens major histocompatibility complex, class I, H (pseudogene) (HLA-H), non-coding RNA.	114	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to membrane	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						CAGAGCGAGGGCGGTGAGTGA	0.667000														93			5		0	0	0.105934	0	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr3:195505836G>C	uc021xjp.1	-	1	12771	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_Intron|MUC4_uc021xjn.1_Intron|MUC4_uc021xjo.1_Intron|MUC4_uc021xjg.1_Intron|MUC4_uc021xjh.1_Intron|MUC4_uc021xji.1_Intron|MUC4_uc021xjj.1_Intron|MUC4_uc021xjk.1_Intron|MUC4_uc021xjl.1_Intron|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000														20			5		0	0	0.184627	0	0
BC107568	0	broad.mit.edu	37	GL000195.1	138107	138107	+	RNA	SNP	T	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrGL000195.1:138107T>C	uc003won.1	+	0		c.141T>C								Homo sapiens cDNA clone IMAGE:3683736.																		GACGCATAGTTAAGGTGCCAG	0.602000														88			6		0	0	0.335167	0	0
FLJ43315	644316	broad.mit.edu	37	GL000211.1	86122	86122	+	RNA	SNP	G	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrGL000211.1:86122G>T	uc003bnz.1	+	5		c.870G>T			FLJ43315_uc003boa.3_Non-coding_Transcript					Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding RNA.																		GCTATGAAGAGTGCACACAGG	0.468000														58			5		0.00307968	0.00313101	0.278610	1	0
FCGBP	8857	broad.mit.edu	37	19	40396062	40396062	+	Silent	SNP	G	A	A			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:40396062G>A	uc002omp.4	-	14	7343	c.7335C>T	c.(7333-7335)tgC>tgT	p.C2445C		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Homo sapiens Fc fragment of IgG binding protein (FCGBP), mRNA.	2445						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCACGGCCACGCAGCCCAAGC	0.677000														126			8		0	0	0.146539	0	0
WASH2P	375260	broad.mit.edu	37	2	114355998	114355998	+	Missense_Mutation	SNP	C	G	G			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:114355998C>G	uc002tkh.3	+	4	674	c.616C>G	c.(616-618)Cac>Gac	p.H206D	WASH2P_uc002tka.3_Non-coding_Transcript|WASH2P_uc002tkd.3_Non-coding_Transcript					Homo sapiens WAS protein family homolog 2 pseudogene (WASH2P), non-coding RNA.																		CCAAGGTGGGCACTTGATGTC	0.612000														63			6		0	0	0.307466	0	0
FRG1B	284802	broad.mit.edu	37	20	29624093	29624093	+	Splice_Site	SNP	G	T	T	rs75468660		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr20:29624093G>T	uc010ztl.1	+	1	58	c.26_splice	c.e1+1	p.R9_splice	FRG1B_uc002wvm.1_Intron|FRG1B_uc010ztj.1_Intron|FRG1B_uc010gdr.1_Intron|FRG1B_uc010ztk.1_Intron					Homo sapiens FSHD region gene 1 family, member B (FRG1B), non-coding RNA.									p.?(6)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						CTGATTCCAGGTGAGCTTATG	0.299000														128			6		1.58986e-06	1.79596e-06	0.069234	1	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342197	60342197	+	RNA	SNP	T	C	C	rs76635225		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr17:60342197T>C	uc010woz.2	-	13		c.1932A>G								Homo sapiens TBC1 domain family, member 3 pseudogene 2 (TBC1D3P2), non-coding RNA.											breast(2)|kidney(1)|lung(2)	5						TGGGAGGGGCTGGGCATGGTT	0.488000														116			6		0	0	0.278610	0	0
FLJ43315	644316	broad.mit.edu	37	GL000211.1	91795	91795	+	RNA	SNP	G	A	A			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrGL000211.1:91795G>A	uc003bnz.1	+	6		c.1151G>A			FLJ43315_uc003boa.3_Non-coding_Transcript					Homo sapiens asparagine synthetase pseudogene (FLJ43315), non-coding RNA.																		CAATTTGTATGTTGGATAGTG	0.383000														89			8		0	0	0.069234	0	0
ANKRD36B	57730	broad.mit.edu	37	2	98201826	98201826	+	Missense_Mutation	SNP	G	A	A			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:98201826G>A	uc010yvc.1	-	1	477	c.197C>T	c.(196-198)cCg>cTg	p.P66L	ANKRD36B_uc010yve.1_Non-coding_Transcript|ANKRD36B_uc010fif.2_Non-coding_Transcript	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	Homo sapiens ankyrin repeat domain 36B (ANKRD36B), mRNA.	66																	TACCATTTCCGGTTGGCCAGT	0.453000														61			5		0	0	0.335167	0	0
LOC645166	645166	broad.mit.edu	37	1	148933289	148933289	+	Splice_Site	SNP	A	G	G	rs9729175	by1000genomes	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:148933289A>G	uc010pbc.1	+	3		c.236_splice	c.e3-2		LOC645166_uc010pbd.1_Intron|LOC645166_uc009wkw.1_Splice_Site					Homo sapiens lymphocyte-specific protein 1 pseudogene (LOC645166), transcript variant 2, non-coding RNA.																		TGCTGCCCGCAGGATATTGTG	0.562000														91			14		0	0	0.132662	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60342186	60342186	+	RNA	SNP	T	C	C	rs79096325		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr17:60342186T>C	uc010woz.2	-	13		c.1943A>G								Homo sapiens TBC1 domain family, member 3 pseudogene 2 (TBC1D3P2), non-coding RNA.											breast(2)|kidney(1)|lung(2)	5						GCTGGGGGTGTTGGGAGGGGC	0.498000														89			6		0	0	0.278610	0	0
MEGF6	1953	broad.mit.edu	37	1	3413612	3413612	+	Missense_Mutation	SNP	G	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:3413612G>C	uc001akl.3	-	27	3780	c.3553C>G	c.(3553-3555)Cac>Gac	p.H1185D	MEGF6_uc001akk.3_Intron	NM_001409	NP_001400	O75095	MEGF6_HUMAN	Homo sapiens multiple EGF-like-domains 6 (MEGF6), mRNA.	1185						extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GTGGCAGGGTGGCAGGCCGGG	0.692000														26			3		0	0	0.115264	0	0
BC080605	0	broad.mit.edu	37	9	68414289	68414289	+	RNA	SNP	C	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr9:68414289C>T	uc004aex.3	+	0		c.844C>T								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		ggaagacttgcaagtctctca	0.443000														21			4		0	0	0.248553	0	0
KAT6B	23522	broad.mit.edu	37	10	76789141	76789141	+	Missense_Mutation	SNP	G	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr10:76789141G>C	uc001jwn.1	+	17	5052	c.4559G>C	c.(4558-4560)aGc>aCc	p.S1520T	KAT6B_uc001jwo.1_Missense_Mutation_p.S1228T|KAT6B_uc001jwp.1_Missense_Mutation_p.S1337T	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	Homo sapiens K(lysine) acetyltransferase 6B (KAT6B), mRNA.	1520					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CAAAAGAACAGCAAGGAAGTC	0.552000														408			14		0	0	0.105934	0	0
PLEKHG5	57449	broad.mit.edu	37	1	6536011	6536013	+	In_Frame_Del	DEL	CTC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:6536011_6536013delCTC	uc001anp.1	-	3	856_858	c.358_360delGAG	c.(358-360)gagdel	p.E120del	PLEKHG5_uc001ann.1_In_Frame_Del_p.E80del|PLEKHG5_uc001ano.1_In_Frame_Del_p.E99del|PLEKHG5_uc001anq.1_In_Frame_Del_p.E120del|PLEKHG5_uc009vma.1_5'UTR|PLEKHG5_uc010nzr.1_In_Frame_Del_p.E112del|PLEKHG5_uc001ank.1_In_Frame_Del_p.E43del|PLEKHG5_uc009vmb.1_In_Frame_Del_p.E43del|PLEKHG5_uc001anl.1_In_Frame_Del_p.E43del|PLEKHG5_uc001anm.1_In_Frame_Del_p.E43del	NM_198681	NP_065682	O94827	PKHG5_HUMAN	Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 5 (PLEKHG5), transcript variant 2, mRNA.	99					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCACAGAGCTCTCCTCCTCCTCC	0.631											OREG0013041	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	482	---	---	7	---					
JAK1	3716	broad.mit.edu	37	1	65306996	65306997	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:65306996_65306997insT	uc001dbu.1	-	18	2829_2830	c.2580_2581insA	c.(2578-2583)aaaccafs	p.K860fs	JAK1_uc009wam.1_Frame_Shift_Ins_p.K860fs|JAK1_uc009wal.1_Frame_Shift_Ins_p.K37fs	NM_002227	NP_002218	P23458	JAK1_HUMAN	Homo sapiens Janus kinase 1 (JAK1), mRNA.	860					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCAGTTGCTGGTTTTTTTTCTG	0.470			Mis		ALL								---	632	---	---	10	---					
LPAR3	23566	broad.mit.edu	37	1	85331664	85331665	+	Frame_Shift_Ins	INS	-	A	A	rs76299065		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:85331664_85331665insA	uc001dkl.2	-	0	178_179	c.139_140insT	c.(139-141)tctfs	p.S47fs	LPAR3_uc009wcj.1_Frame_Shift_Ins_p.S47fs	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	Homo sapiens lysophosphatidic acid receptor 3 (LPAR3), mRNA.	47					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						CAGAGAATTAGAAAAAAAAATA	0.401													---	698	---	---	10	---					
RBMXL1	494115	broad.mit.edu	37	1	89448500	89448501	+	In_Frame_Ins	INS	-	CAT	CAT			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:89448500_89448501insCAT	uc021opo.1	-	0	1009_1010	c.1009_1010insATG	c.(1009-1011)agt>aATGgt	p.337_337S>NG	CCBL2_uc001dmp.2_Intron|CCBL2_uc001dmq.2_Intron|CCBL2_uc001dmr.2_Intron|RBMXL1_uc009wcx.3_In_Frame_Ins_p.337_337S>NG|RBMXL1_uc001dms.3_In_Frame_Ins_p.337_337S>NG	NM_019610	NP_062556	Q96E39	RBMXL_HUMAN	Homo sapiens RNA binding motif protein, X-linked-like 1 (RBMXL1), transcript variant 2, mRNA.	337	Ser-rich.						RNA binding|nucleotide binding										CCTGTCACAACTTGAGTAGAGA	0.500													---	1515	---	---	12	---					
BRDT	676	broad.mit.edu	37	1	92447228	92447230	+	In_Frame_Del	DEL	AGC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:92447228_92447230delAGC	uc001dol.4	+	12	2336_2338	c.1918_1920delAGC	c.(1918-1920)agcdel	p.S648del	BRDT_uc010osz.2_In_Frame_Del_p.S652del|BRDT_uc001dok.4_In_Frame_Del_p.S648del|BRDT_uc009wdf.3_In_Frame_Del_p.S575del|BRDT_uc010otb.2_In_Frame_Del_p.S602del|BRDT_uc010ota.2_In_Frame_Del_p.S602del|BRDT_uc001dom.4_In_Frame_Del_p.S648del	NM_001242805	NP_001229734	Q58F21	BRDT_HUMAN	Homo sapiens bromodomain, testis-specific (BRDT), transcript variant 3, mRNA.	648	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		ACTGAGTGAGagcagcagcagca	0.419													---	523	---	---	7	---					
CLCC1	23155	broad.mit.edu	37	1	109477407	109477407	+	Frame_Shift_Del	DEL	T	-	-	rs150759040	by1000genomes	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:109477407delT	uc021ora.1	-	9	1552	c.1541delA	c.(1540-1542)aagfs	p.K514fs	AKNAD1_uc010ovb.2_Intron|CLCC1_uc001dwg.1_Frame_Shift_Del_p.K464fs|CLCC1_uc001dwf.1_Frame_Shift_Del_p.K514fs|CLCC1_uc009wes.1_Frame_Shift_Del_p.K393fs|CLCC1_uc009wet.1_Frame_Shift_Del_p.K329fs	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Homo sapiens chloride channel CLIC-like 1 (CLCC1), transcript variant 1, mRNA.	514						Golgi apparatus|endoplasmic reticulum|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		GAGCTGGGCCTTTTCCGCTGC	0.597													---	788	---	---	7	---					
ADAM30	11085	broad.mit.edu	37	1	120436591	120436591	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:120436591delT	uc001eij.3	-	0	2557	c.2369delA	c.(2368-2370)aagfs	p.K790fs		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	Homo sapiens ADAM metallopeptidase domain 30 (ADAM30), mRNA.	790					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GCCCGGTTACTTTTTTTGTTT	0.358													---	1307	---	---	9	---					
SV2A	9900	broad.mit.edu	37	1	149885223	149885225	+	In_Frame_Del	DEL	TCA	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:149885223_149885225delTCA	uc001etg.3	-	1	659_661	c.168_170delTGA	c.(166-171)gatgac>gac	p.56_57DD>D	SV2A_uc001eth.2_In_Frame_Del_p.56_57DD>D	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	Homo sapiens synaptic vesicle glycoprotein 2A (SV2A), mRNA.	56	Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	AGCAGGGAAGTCATCATCATCAT	0.542													---	624	---	---	7	---					
ADAMTSL4	54507	broad.mit.edu	37	1	150530506	150530506	+	Frame_Shift_Del	DEL	G	-	-	rs149280379		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:150530506delG	uc009wlw.3	+	13	2490	c.2332delG	c.(2332-2334)gggfs	p.G778fs	ADAMTSL4_uc001euw.3_Frame_Shift_Del_p.G755fs|ADAMTSL4_uc001eux.3_Frame_Shift_Del_p.G755fs|ADAMTSL4_uc010pcg.2_Frame_Shift_Del_p.G716fs|ADAMTSL4_uc009wlx.3_5'UTR	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	Homo sapiens ADAMTS-like 4 (ADAMTSL4), transcript variant 1, mRNA.	755	TSP type-1 2.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCAGGAATTTGGGGGGGGTGG	0.692													---	667	---	---	10	---					
FLG2	388698	broad.mit.edu	37	1	152324558	152324559	+	Frame_Shift_Del	DEL	TG	-	-	rs140875805	byFrequency	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:152324558_152324559delTG	uc001ezw.4	-	2	5776_5777	c.5703_5704delCA	c.(5701-5706)cacagcfs	p.H1901fs	AK056431_uc001ezv.3_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	Homo sapiens filaggrin family member 2 (FLG2), mRNA.	1901							calcium ion binding|structural molecule activity	p.H1901fs*30(2)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTTGGCTGTGTGTGTGTC	0.515													---	1593	---	---	9	---					
ISG20L2	81875	broad.mit.edu	37	1	156694023	156694023	+	Frame_Shift_Del	DEL	G	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:156694023delG	uc001fps.1	-	1	1126	c.865delC	c.(865-867)ctcfs	p.L289fs	ISG20L2_uc001fpt.1_Frame_Shift_Del_p.L289fs	NM_030980	NP_112242	Q9H9L3	I20L2_HUMAN	Homo sapiens interferon stimulated exonuclease gene 20kDa-like 2 (ISG20L2), mRNA.	289	Exonuclease.				ribosome biogenesis	nucleolus	exonuclease activity|nucleic acid binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTCCGGTTGAGGGGGGGGATA	0.557													---	571	---	---	12	---					
INTS7	25896	broad.mit.edu	37	1	212115191	212115193	+	In_Frame_Del	DEL	TGC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:212115191_212115193delTGC	uc001hiw.2	-	19	3085_3087	c.2862_2864delGCA	c.(2860-2865)cagcaa>caa	p.954_955QQ>Q	INTS7_uc001hix.2_In_Frame_Del_p.830_831QQ>Q|INTS7_uc009xdb.2_In_Frame_Del_p.934_935QQ>Q|INTS7_uc001hiy.2_In_Frame_Del_p.940_941QQ>Q|INTS7_uc010pta.2_In_Frame_Del_p.905_906QQ>Q	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	Homo sapiens integrator complex subunit 7 (INTS7), transcript variant 1, mRNA.	954	Gln-rich.				snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GGCATTGCGTTGCTGCTGCTGCT	0.443													---	852	---	---	8	---					
TGFB2	7042	broad.mit.edu	37	1	218609370	218609371	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:218609370_218609371insA	uc001hlm.3	+	4	2181_2182	c.813_814insA	c.(811-816)aggaaafs	p.R271fs	TGFB2_uc001hln.3_Frame_Shift_Ins_p.R299fs|TGFB2_uc010pue.2_Intron|TGFB2_uc001hlo.3_Intron	NM_003238	NP_003229	P61812	TGFB2_HUMAN	Homo sapiens transforming growth factor, beta 2 (TGFB2), transcript variant 2, mRNA.	271					SMAD protein import into nucleus|activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		AGTCCACTAGGAAAAAAAACAG	0.431													---	466	---	---	7	---					
OR2T2	401992	broad.mit.edu	37	1	248616705	248616711	+	Frame_Shift_Del	DEL	TGCTGCG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr1:248616705_248616711delTGCTGCG	uc001iek.1	+	0	607_613	c.607_613delTGCTGCG	c.(607-615)tgctgcgtgfs	p.C203fs		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily T, member 2 (OR2T2), mRNA.	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGTATGCCTGCTGCGTGCTGATGCT	0.527													---	563	---	---	7	---					
ATP6V1C2	245973	broad.mit.edu	37	2	10917819	10917820	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:10917819_10917820delAG	uc002ras.3	+	10	1043_1044	c.934_935delAG	c.(934-936)agafs	p.R312fs	ATP6V1C2_uc002rat.3_Intron	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 (ATP6V1C2), transcript variant 1, mRNA.	312					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		GCAGACCGACAGAGAGAGAGAG	0.604													---	526	---	---	13	---					
C2orf71	388939	broad.mit.edu	37	2	29295647	29295649	+	In_Frame_Del	DEL	TCC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:29295647_29295649delTCC	uc002rmt.2	-	0	1479_1481	c.1479_1481delGGA	c.(1477-1482)gaggaa>gaa	p.493_494EE>E		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	Homo sapiens chromosome 2 open reading frame 71 (C2orf71), mRNA.	493					response to stimulus|visual perception	photoreceptor outer segment		p.E492K(1)		NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CATTTTGTCTTCCTCCTCCTCCT	0.542													---	888	---	---	7	---					
VRK2	7444	broad.mit.edu	37	2	58373509	58373509	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:58373509delA	uc002rzo.2	+	14	1827	c.1082delA	c.(1081-1083)gaafs	p.E361fs	VRK2_uc010fcb.2_Frame_Shift_Del_p.E361fs|VRK2_uc002rzt.3_Frame_Shift_Del_p.E243fs|VRK2_uc002rzs.3_Frame_Shift_Del_p.E361fs|VRK2_uc002rzv.3_Frame_Shift_Del_p.E361fs|VRK2_uc010fcd.3_Frame_Shift_Del_p.E338fs|VRK2_uc002rzu.3_Frame_Shift_Del_p.E361fs|VRK2_uc010fcc.3_Frame_Shift_Del_p.E243fs|VRK2_uc002rzp.3_Frame_Shift_Del_p.E361fs|VRK2_uc010ypg.2_Frame_Shift_Del_p.E361fs	NM_001130482	NP_001123954	Q86Y07	VRK2_HUMAN	Homo sapiens vaccinia related kinase 2 (VRK2), transcript variant 4, mRNA.	361						integral to membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	24						AGGTTAATCGAAAAAAAAGTC	0.383													---	357	---	---	8	---					
BCL11A	53335	broad.mit.edu	37	2	60689253	60689254	+	Frame_Shift_Ins	INS	-	G	G			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:60689253_60689254insG	uc002sae.1	-	3	1021_1022	c.793_794insC	c.(793-795)ctgfs	p.L265fs	BCL11A_uc002sab.3_Frame_Shift_Ins_p.L265fs|BCL11A_uc002sac.3_Intron|BCL11A_uc010ypi.2_Intron|BCL11A_uc010ypj.2_Frame_Shift_Ins_p.L231fs|BCL11A_uc002sad.1_Frame_Shift_Ins_p.L113fs|BCL11A_uc002saf.1_Frame_Shift_Ins_p.L231fs	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	Homo sapiens B-cell CLL/lymphoma 11A (zinc finger protein) (BCL11A), transcript variant 1, mRNA.	265	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGGACTAAACAGGGGGGGAGTG	0.584			T	IGH@	B-CLL								---	329	---	---	8	---					
WBP1	23559	broad.mit.edu	37	2	74687550	74687550	+	Frame_Shift_Del	DEL	T	-	-	rs8469	byFrequency	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:74687550delT	uc002slj.2	+	3	755	c.552delT	c.(550-552)cctfs	p.P184fs	INO80B_uc002sli.2_Non-coding_Transcript|WBP1_uc002sll.2_Non-coding_Transcript	NM_012477	NP_036609	Q96G27	WBP1_HUMAN	Homo sapiens WW domain binding protein 1 (WBP1), mRNA.	184							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						GTGCCCCCCCTCATCAGGAGG	0.612													---	767	---	---	10	---					
RGPD1	400966	broad.mit.edu	37	2	87211874	87211875	+	Splice_Site	INS	-	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:87211874_87211875insC	uc010fgv.3	+	19	2620	c.2582_splice	c.e19-2	p.V861_splice	RMND5A_uc002srs.4_Intron|RGPD1_uc021vkh.1_Splice_Site_p.V853_splice|RGPD1_uc002ssc.3_Splice_Site_p.V118_splice	NM_001078170	NP_001071638	Q68DN6	RGPD1_HUMAN	Homo sapiens RANBP2-like and GRIP domain containing 2 (RGPD2), mRNA.	853					intracellular transport		binding			breast(1)|endometrium(1)|lung(1)	3						tttttttttttAGTTGCAACTA	0.327													---	222	---	---	7	---					
LIPT1	51601	broad.mit.edu	37	2	99778781	99778781	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:99778781delA	uc002szp.4	+	2	522	c.484delA	c.(484-486)aaafs	p.K162fs	MRPL30_uc002szl.1_Intron|LIPT1_uc002szm.4_Frame_Shift_Del_p.K121fs|LIPT1_uc002szn.4_Frame_Shift_Del_p.K121fs|LIPT1_uc002szo.4_Frame_Shift_Del_p.K121fs|LIPT1_uc002szq.4_Frame_Shift_Del_p.K121fs|MRPL30_uc002szr.3_Intron|LIPT1_uc021vln.1_Frame_Shift_Del_p.K121fs|LIPT1_uc021vlo.1_Frame_Shift_Del_p.K121fs|LIPT1_uc021vlp.1_Frame_Shift_Del_p.K121fs	NM_145199	NP_660200	Q9Y234	LIPT_HUMAN	Homo sapiens lipoyltransferase 1 (LIPT1), nuclear gene encoding mitochondrial protein, transcript variant 5, mRNA.	121					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity			large_intestine(6)|lung(1)	7					Lipoic Acid(DB00166)	CTTTACAACCAAAAAAAAGTA	0.388													---	395	---	---	9	---					
ERCC3	2071	broad.mit.edu	37	2	128046944	128046946	+	In_Frame_Del	DEL	TCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:128046944_128046946delTCT	uc002toh.1	-	5	884_886	c.789_791delAGA	c.(787-792)gaagag>gag	p.263_264EE>E	ERCC3_uc002toe.1_In_Frame_Del_p.18_19EE>E|ERCC3_uc002tof.1_In_Frame_Del_p.199_200EE>E|ERCC3_uc002tog.1_In_Frame_Del_p.199_200EE>E|ERCC3_uc010flx.1_In_Frame_Del_p.18_19EE>E|ERCC3_uc010yzh.1_Non-coding_Transcript	NM_000122	NP_000113	P19447	ERCC3_HUMAN	Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) (ERCC3), mRNA.	263	Asp/Glu-rich (acidic).				DNA topological change|cell cycle checkpoint|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TGTCTGTGTCTCTTCTTCTTCTT	0.473			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				---	304	---	---	7	---					
FMNL2	114793	broad.mit.edu	37	2	153504389	153504390	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:153504389_153504390delTT	uc002tye.3	+	25	3616_3617	c.3249_3250delTT	c.(3247-3252)cgttctfs	p.R1083fs	FMNL2_uc010fob.3_3'UTR|FMNL2_uc002tyf.3_3'UTR	NM_052905	NP_443137	Q96PY5	FMNL2_HUMAN	Homo sapiens formin-like 2 (FMNL2), mRNA.	0					actin cytoskeleton organization	cytoplasm	Rho GTPase binding|actin binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						AGAACTTGCGTTCTGTTAATGG	0.495													---	1053	---	---	10	---					
PPIG	9360	broad.mit.edu	37	2	170493804	170493804	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:170493804delA	uc002uez.3	+	13	2256	c.2036delA	c.(2035-2037)gaafs	p.E679fs	PPIG_uc010fpx.3_Frame_Shift_Del_p.E664fs|PPIG_uc010fpy.3_Frame_Shift_Del_p.E672fs|PPIG_uc002ufb.3_Frame_Shift_Del_p.E679fs|PPIG_uc002ufd.3_Frame_Shift_Del_p.E676fs	NM_004792	NP_004783	Q13427	PPIG_HUMAN	Homo sapiens peptidylprolyl isomerase G (cyclophilin G) (PPIG), mRNA.	679					RNA splicing|protein folding	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AACAGCAGGGAAAAAAAGGCT	0.358													---	442	---	---	7	---					
RBM45	129831	broad.mit.edu	37	2	178977303	178977304	+	Frame_Shift_Ins	INS	-	G	G	rs146365140	by1000genomes	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:178977303_178977304insG	uc002ulv.3	+	0	122_123	c.30_31insG	c.(28-33)ggcgggfs	p.G10fs		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	Homo sapiens RNA binding motif protein 45 (RBM45), mRNA.	10					cell differentiation|nervous system development	cytoplasm|nucleus	RNA binding|nucleotide binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			CTGCGAGCGGCGGGGGCTTCCG	0.644											OREG0015102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	290	---	---	7	---					
KANSL1L	151050	broad.mit.edu	37	2	210887680	210887680	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:210887680delT	uc002vds.3	-	14	3165	c.2957delA	c.(2956-2958)aatfs	p.N986fs	KANSL1L_uc002vdt.3_Frame_Shift_Del_p.N944fs	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	Homo sapiens chromosome 2 open reading frame 67 (C2orf67), mRNA.	986																	CTGTCACCTATTTTTTTTAAC	0.418													---	262	---	---	7	---					
DOCK10	55619	broad.mit.edu	37	2	225729790	225729790	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:225729790delA	uc010fwz.1	-	11	1511	c.1272delT	c.(1270-1272)tttfs	p.F424fs	DOCK10_uc002vob.2_Frame_Shift_Del_p.F418fs|DOCK10_uc002vod.1_Frame_Shift_Del_p.F424fs	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	Homo sapiens dedicator of cytokinesis 10 (DOCK10), mRNA.	424							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CCACACTCACAAAAAAAGGCT	0.398													---	624	---	---	8	---					
IRS1	3667	broad.mit.edu	37	2	227660808	227660810	+	In_Frame_Del	DEL	GCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:227660808_227660810delGCT	uc021vxn.1	-	0	2645_2647	c.2645_2647delAGC	c.(2644-2649)cagccc>ccc	p.Q882del	IRS1_uc002voh.4_In_Frame_Del_p.Q882del	NM_005544	NP_005535	P35568	IRS1_HUMAN	Homo sapiens insulin receptor substrate 1 (IRS1), mRNA.	882	Poly-Gln.				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	SH2 domain binding|insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(10)|lung(33)|ovary(6)|pancreas(1)|prostate(1)|urinary_tract(2)	69		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		TGCAGCAAGGgctgctgctgctg	0.626													---	418	---	---	8	---					
COL4A4	1286	broad.mit.edu	37	2	227896886	227896886	+	Frame_Shift_Del	DEL	C	-	-	rs2229812	by1000genomes	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr2:227896886delC	uc021vxr.1	-	37	3785	c.3684delG	c.(3682-3684)aagfs	p.K1228fs	COL4A4_uc021vxs.1_Frame_Shift_Del_p.K1228fs	NM_000092	NP_000083	P53420	CO4A4_HUMAN	Homo sapiens collagen, type IV, alpha 4 (COL4A4), mRNA.	1228	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGGGACCTTTCTTTCCACGAG	0.522													---	587	---	---	7	---					
DLEC1	9940	broad.mit.edu	37	3	38162039	38162040	+	Frame_Shift_Del	DEL	GA	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr3:38162039_38162040delGA	uc003chp.1	+	33	4826_4827	c.4805_4806delGA	c.(4804-4806)ggafs	p.G1602fs	DLEC1_uc003cho.1_Frame_Shift_Del_p.G1602fs|DLEC1_uc010hgv.1_Frame_Shift_Del_p.G1605fs|DLEC1_uc003chr.1_Frame_Shift_Del_p.G673fs|DLEC1_uc003chs.1_Frame_Shift_Del_p.G159fs	NM_007337	NP_031363	Q9Y238	DLEC1_HUMAN	Homo sapiens deleted in lung and esophageal cancer 1 (DLEC1), transcript variant DLEC1-S3, mRNA.	1602					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		AGTGCGAGTGGAGAGAGAGAGA	0.579													---	369	---	---	10	---					
ROBO2	6092	broad.mit.edu	37	3	77657037	77657038	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr3:77657037_77657038insC	uc011bgk.2	+	21	3880_3881	c.3237_3238insC	c.(3235-3240)cctcccfs	p.P1079fs	ROBO2_uc021xat.1_Frame_Shift_Ins_p.P1091fs|ROBO2_uc003dpy.4_Frame_Shift_Ins_p.P1075fs|ROBO2_uc003dpz.3_Frame_Shift_Ins_p.P1079fs|ROBO2_uc011bgj.2_Non-coding_Transcript|ROBO2_uc003dqa.3_Frame_Shift_Ins_p.P202fs	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	Homo sapiens roundabout, axon guidance receptor, homolog 2 (Drosophila) (ROBO2), transcript variant 2, mRNA.	1075					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding	p.V1079fs*22(2)|p.V1095fs*22(1)		NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TCCCTCTACCTCCCCCCCCAGT	0.431													---	323	---	---	7	---					
MYLK	4638	broad.mit.edu	37	3	123368043	123368044	+	Splice_Site	INS	-	G	G	rs138786404		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr3:123368043_123368044insG	uc003ego.3	-	25	4571	c.4289_splice	c.e25-1	p.E1430_splice	MYLK_uc010hrr.3_Splice_Site|MYLK_uc011bjv.2_Splice_Site_p.E230_splice|MYLK_uc011bjw.2_Splice_Site_p.E1430_splice|MYLK_uc003egp.3_Splice_Site_p.E1361_splice|MYLK_uc003egq.3_Splice_Site_p.E1430_splice|MYLK_uc003egr.3_Splice_Site_p.E1361_splice|MYLK_uc003egs.3_Splice_Site_p.E1254_splice	NM_053025	NP_444253	Q15746	MYLK_HUMAN	Homo sapiens myosin light chain kinase (MYLK), transcript variant 1, mRNA.	1430	Actin-binding (calcium/calmodulin- insensitive) (By similarity).				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	ATP binding|actin binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTTCGGCTCTGGGGGGGGCAC	0.624													---	538	---	---	9	---					
PDGFRA	5156	broad.mit.edu	37	4	54319248	54319249	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr4:54319248_54319249delAG	uc003gzy.3	+	15	1633_1634	c.1447_1448delAG	c.(1447-1449)agafs	p.R483fs	PDGFRA_uc003haa.3_Intron|PDGFRA_uc011bzu.2_Frame_Shift_Del_p.R477fs|PDGFRA_uc003gzz.3_Frame_Shift_Del_p.R409fs|PDGFRA_uc003hab.3_Frame_Shift_Del_p.R448fs|PDGFRA_uc010ign.3_Non-coding_Transcript|FIP1L1_uc003hae.3_Frame_Shift_Del_p.P67fs	NM_030917	NP_112179	P16234	PGFRA_HUMAN	Homo sapiens FIP1 like 1 (S. cerevisiae) (FIP1L1), transcript variant 1, mRNA.	0	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of DNA replication|positive regulation of cell migration|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity	p.R487fs*3(2)		NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	agaACGCACCAGAGAGAGAGAG	0.470			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			---	347	---	---	11	---					
NAP1L5	266812	broad.mit.edu	37	4	89618431	89618433	+	In_Frame_Del	DEL	CCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr4:89618431_89618433delCCT	uc003hrx.3	-	0	591_593	c.473_475delAGG	c.(472-477)gaggct>gct	p.E158del	HERC3_uc011cdn.1_Intron|HERC3_uc003hrw.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	Homo sapiens nucleosome assembly protein 1-like 5 (NAP1L5), mRNA.	158	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		TCTGCCGCAGcctcctcctcctc	0.626													---	705	---	---	7	---					
MAML3	55534	broad.mit.edu	37	4	140810639	140810641	+	In_Frame_Del	DEL	GCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr4:140810639_140810641delGCT	uc021xsg.1	-	1	2701_2703	c.1949_1951delAGC	c.(1948-1953)cagccg>ccg	p.Q650del	MAML3_uc011chd.1_Intron	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	Homo sapiens mastermind-like 3 (Drosophila) (MAML3), mRNA.	646	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					GGAGGTGGCGgctgctgctgctg	0.586													---	342	---	---	9	---					
DUX2	26583	broad.mit.edu	37	4	190989660	190989660	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr4:190989660delC	uc021xvp.1	+	0	794	c.754delC	c.(754-756)cccfs	p.P252fs	DUX4L4_uc021xvq.1_5'Flank	NM_012147	NP_036279			Homo sapiens double homeobox 2 (DUX2), mRNA.																		AACGGGGCTTCCCGCACCCCA	0.786													---	725	---	---	9	---					
PCDHB14	56122	broad.mit.edu	37	5	140605423	140605423	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr5:140605423delT	uc003ljb.3	+	0	2346	c.2346delT	c.(2344-2346)aatfs	p.N782fs		NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	Homo sapiens protocadherin beta 14 (PCDHB14), mRNA.	782					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGTAGGAATATGGGGGAAA	0.368													---	554	---	---	9	---					
BNIP1	662	broad.mit.edu	37	5	172578611	172578611	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr5:172578611delT	uc003mci.4	+	2	324	c.220delT	c.(220-222)tttfs	p.F74fs	BNIP1_uc003mcj.4_Intron|BNIP1_uc003mck.4_Frame_Shift_Del_p.F74fs|BNIP1_uc003mcl.4_Intron|BNIP1_uc021yhw.1_Intron	NM_013979	NP_053582	Q12981	SEC20_HUMAN	Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 1 (BNIP1), transcript variant BNIP1-b, mRNA.	59					anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	SNARE complex|integral to endoplasmic reticulum membrane|nuclear envelope	protein binding			breast(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	11	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TGCTTCCACATTTTTTTTTAA	0.348													---	439	---	---	11	---					
SYNGAP1	8831	broad.mit.edu	37	6	33411201	33411203	+	In_Frame_Del	DEL	CAC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:33411201_33411203delCAC	uc011dri.2	+	14	3067_3069	c.2872_2874delCAC	c.(2872-2874)cacdel	p.H966del	SYNGAP1_uc010juy.3_In_Frame_Del_p.H937del|SYNGAP1_uc010juz.3_In_Frame_Del_p.H678del	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	Homo sapiens synaptic Ras GTPase activating protein 1 (SYNGAP1), mRNA.	966					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TTCCTCccatcaccaccaccacc	0.645													---	904	---	---	8	---					
HSP90AB1	3326	broad.mit.edu	37	6	44221052	44221052	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:44221052delT	uc003oxa.1	+	10	2086	c.2002delT	c.(2002-2004)tttfs	p.F668fs	HSP90AB1_uc011dvr.1_Frame_Shift_Del_p.F658fs|HSP90AB1_uc003oxb.1_Frame_Shift_Del_p.F668fs|HSP90AB1_uc011dvs.1_Frame_Shift_Del_p.F488fs|HSP90AB1_uc003oxc.1_Frame_Shift_Del_p.F306fs	NM_007355	NP_031381	P08238	HS90B_HUMAN	Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), mRNA.	668					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|TPR domain binding|nitric-oxide synthase regulator activity|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ATCTTCTGGCTTTTCCCTTGA	0.527													---	2344	---	---	8	---					
MYO6	4646	broad.mit.edu	37	6	76599857	76599858	+	Frame_Shift_Ins	INS	-	A	A			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:76599857_76599858insA	uc003pih.1	+	25	3021_3022	c.2742_2743insA	c.(2740-2745)cagaaafs	p.Q914fs	MYO6_uc003pig.1_Frame_Shift_Ins_p.Q914fs|MYO6_uc003pii.1_Frame_Shift_Ins_p.Q914fs	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	Homo sapiens myosin VI (MYO6), mRNA.	914					DNA damage response, signal transduction by p53 class mediator|actin filament-based movement|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	DNA-directed RNA polymerase II, holoenzyme|Golgi apparatus|cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|filamentous actin|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	ADP binding|ATP binding|actin filament binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding	p.K917fs*10(1)		breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GTGCATTACAGAAAAAAAAACA	0.381													---	413	---	---	14	---					
KIAA1009	22832	broad.mit.edu	37	6	84896233	84896233	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:84896233delA	uc010kbp.3	-	11	1315	c.1218delT	c.(1216-1218)tttfs	p.F406fs	KIAA1009_uc003pkj.4_Frame_Shift_Del_p.F330fs|KIAA1009_uc003pkk.2_Frame_Shift_Del_p.F406fs|KIAA1009_uc003pki.4_5'UTR	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	Homo sapiens KIAA1009 (KIAA1009), mRNA.	406					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		CATTTTTGTCAAAAAAAAGGT	0.358													---	725	---	---	13	---					
ARHGAP18	93663	broad.mit.edu	37	6	129959602	129959603	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:129959602_129959603insT	uc003qbr.3	-	2	577_578	c.488_489insA	c.(487-489)aacfs	p.N163fs	ARHGAP18_uc011ebw.2_Frame_Shift_Ins_p.N163fs|ARHGAP18_uc021zfe.1_Frame_Shift_Ins_p.N160fs	NM_033515	NP_277050	Q8N392	RHG18_HUMAN	Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.	163					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		GGTACTGTTTGTTTTTTTTCCT	0.421													---	1171	---	---	9	---					
MED23	9439	broad.mit.edu	37	6	131919846	131919846	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr6:131919846delT	uc003qcs.1	-	18	2450	c.2276delA	c.(2275-2277)aatfs	p.N759fs	MED23_uc003qcq.3_Frame_Shift_Del_p.N765fs|MED23_uc011eca.1_Frame_Shift_Del_p.N400fs|MED23_uc003qct.1_Frame_Shift_Del_p.N765fs	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	Homo sapiens mediator complex subunit 23 (MED23), transcript variant 1, mRNA.	759					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity	p.N759fs*7(2)|p.N765fs*7(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CTCCTCCACATTTTTTTTCAG	0.378													---	514	---	---	9	---					
NEUROD6	63974	broad.mit.edu	37	7	31378634	31378635	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr7:31378634_31378635insT	uc003tch.3	-	1	601_602	c.248_249insA	c.(247-249)aagfs	p.K83fs	NEUROD6_uc022abi.1_Frame_Shift_Ins_p.K83fs	NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	Homo sapiens neurogenic differentiation 6 (NEUROD6), mRNA.	83					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						GCTTTGTTGTCTTTTTTTTCCT	0.520													---	1251	---	---	11	---					
OGDH	4967	broad.mit.edu	37	7	44684936	44684936	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr7:44684936delT	uc003tln.3	+	2	392	c.233delT	c.(232-234)attfs	p.I78fs	OGDH_uc003tlm.3_Frame_Shift_Del_p.I78fs|OGDH_uc011kbx.2_Frame_Shift_Del_p.I78fs|OGDH_uc011kby.2_Intron|OGDH_uc003tlp.3_Frame_Shift_Del_p.I78fs|OGDH_uc011kbz.2_5'UTR|OGDH_uc003tlo.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	Homo sapiens oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (OGDH), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	78					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding	p.R81fs*19(1)		breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	TCATGGGACATTTTTTTTCGC	0.577													---	885	---	---	10	---					
AKAP9	10142	broad.mit.edu	37	7	91671392	91671393	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr7:91671392_91671393delAG	uc003ulg.3	+	18	5175_5176	c.4950_4951delAG	c.(4948-4953)tcagagfs	p.S1650fs	AKAP9_uc003ulf.3_Frame_Shift_Del_p.S1650fs|AKAP9_uc003uli.3_Frame_Shift_Del_p.S1275fs	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	Homo sapiens A kinase (PRKA) anchor protein (yotiao) 9 (AKAP9), transcript variant 2, mRNA.	1662					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	Golgi apparatus|centrosome|cytosol	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACCTGGTTTCAGAGAGAGAGAG	0.411			T	BRAF	papillary thyroid								---	304	---	---	10	---					
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr7:92146721delT	uc003uly.3	-	4	1204	c.1108delA	c.(1108-1110)attfs	p.I370fs	PEX1_uc011khr.2_Frame_Shift_Del_p.I162fs|PEX1_uc010ley.3_Frame_Shift_Del_p.I370fs|PEX1_uc011khs.2_Intron|PEX1_uc011kht.1_Non-coding_Transcript	NM_000466	NP_000457	O43933	PEX1_HUMAN	Homo sapiens peroxisomal biogenesis factor 1 (PEX1), mRNA.	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353													---	734	---	---	9	---					
FOXP2	93986	broad.mit.edu	37	7	114269971	114269973	+	In_Frame_Del	DEL	CAA	-	-	rs149757187		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr7:114269971_114269973delCAA	uc003vhb.3	+	4	882_884	c.508_510delCAA	c.(508-510)caadel	p.Q191del	FOXP2_uc003vgu.3_Non-coding_Transcript|FOXP2_uc003vgz.3_In_Frame_Del_p.Q216del|FOXP2_uc003vha.3_In_Frame_Del_p.Q99del|FOXP2_uc011kmv.2_In_Frame_Del_p.Q191del|FOXP2_uc011kmu.2_In_Frame_Del_p.Q208del|FOXP2_uc010ljz.2_In_Frame_Del_p.Q99del|FOXP2_uc003vgt.2_Non-coding_Transcript|FOXP2_uc003vgv.1_In_Frame_Del_p.Q191del|FOXP2_uc003vgx.2_In_Frame_Del_p.Q191del|FOXP2_uc003vhc.3_In_Frame_Del_p.Q216del|FOXP2_uc003vhd.3_In_Frame_Del_p.Q191del	NM_014491	NP_055306	O15409	FOXP2_HUMAN	Homo sapiens forkhead box P2 (FOXP2), transcript variant 1, mRNA.	191	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	DNA bending activity|chromatin binding|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q195Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						acagcagcagcaacaacaacaac	0.502													---	253	---	---	12	---					
DLC1	10395	broad.mit.edu	37	8	12957611	12957613	+	In_Frame_Del	DEL	GCT	-	-	rs137989738		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr8:12957611_12957613delGCT	uc003wwm.2	-	8	2677_2679	c.2233_2235delAGC	c.(2233-2235)agcdel	p.S745del	DLC1_uc003wwk.1_In_Frame_Del_p.S308del|DLC1_uc003wwl.1_In_Frame_Del_p.S342del|DLC1_uc011kxx.1_In_Frame_Del_p.S234del	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	Homo sapiens deleted in liver cancer 1 (DLC1), transcript variant 1, mRNA.	745	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of Rho protein signal transduction|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding	p.S744T(1)		NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						TCTCCGACTGGCTGCTGCTGCTG	0.621													---	346	---	---	8	---					
SFRP1	6422	broad.mit.edu	37	8	41166638	41166640	+	In_Frame_Del	DEL	GCT	-	-	rs3055861		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr8:41166638_41166640delGCT	uc003xnt.3	-	0	351_353	c.39_41delAGC	c.(37-42)gcagcc>gcc	p.13_14AA>A		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	Homo sapiens secreted frizzled-related protein 1 (SFRP1), mRNA.	13					DNA fragmentation involved in apoptotic nuclear change|brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of B cell differentiation|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|negative regulation of androgen receptor signaling pathway|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of Rac GTPase activity|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	PDZ domain binding|Wnt receptor activity|Wnt-protein binding|cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CACGCCCAGGGCTGCCCCGCGGC	0.764													---	18	---	---	12	---					
TOX	9760	broad.mit.edu	37	8	59750796	59750798	+	In_Frame_Del	DEL	CTT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr8:59750796_59750798delCTT	uc003xtw.1	-	4	987_989	c.766_768delAAG	c.(766-768)aagdel	p.K256del		NM_014729	NP_055544	O94900	TOX_HUMAN	Homo sapiens thymocyte selection-associated high mobility group box (TOX), mRNA.	256						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				CATTGGGATCCTTCTTCTTCTTC	0.453													---	862	---	---	7	---					
C8orf59	401466	broad.mit.edu	37	8	86129664	86129664	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr8:86129664delT	uc022awy.1	-	2	305	c.65delA	c.(64-66)aacfs	p.N22fs	C8orf59_uc022awz.1_Frame_Shift_Del_p.N22fs|C8orf59_uc022axa.1_Frame_Shift_Del_p.N22fs|C8orf59_uc022axb.1_Frame_Shift_Del_p.N22fs|C8orf59_uc011lfu.2_Non-coding_Transcript	NM_001099670	NP_001093143	Q8N0T1	CH059_HUMAN	Homo sapiens chromosome 8 open reading frame 59 (C8orf59), transcript variant 1, mRNA.	22																	AGCCTTAAAGTTTTTTTGGCT	0.343													---	737	---	---	7	---					
RGS22	26166	broad.mit.edu	37	8	100990177	100990178	+	Frame_Shift_Ins	INS	-	T	T	rs7841915	by1000genomes	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr8:100990177_100990178insT	uc003yjb.1	-	22	3681_3682	c.3486_3487insA	c.(3484-3489)aaattgfs	p.K1162fs	RGS22_uc003yja.1_Frame_Shift_Ins_p.K981fs|RGS22_uc003yjc.1_Frame_Shift_Ins_p.K1150fs|RGS22_uc022azf.1_Frame_Shift_Ins_p.K551fs	NM_015668	NP_056483	Q8NE09	RGS22_HUMAN	Homo sapiens regulator of G-protein signaling 22 (RGS22), mRNA.	1162					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGGACTGCCAATTTTTTTTTCT	0.312													---	344	---	---	8	---					
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	G	G			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr8:110455173_110455174insG	uc003yne.3	+	36	4498	c.4394_splice	c.e36-1	p.G1465_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 (PKHD1L1), mRNA.	1465	IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322										HNSCC(38;0.096)			---	499	---	---	20	---					
COL22A1	169044	broad.mit.edu	37	8	139809072	139809072	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr8:139809072delT	uc003yvd.3	-	11	2033	c.1586delA	c.(1585-1587)aagfs	p.K529fs		NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	Homo sapiens collagen, type XXII, alpha 1 (COL22A1), mRNA.	529	Collagen-like 2.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTTCACCCTTTTCCCCTTG	0.463										HNSCC(7;0.00092)			---	1643	---	---	8	---					
HRCT1	646962	broad.mit.edu	37	9	35906348	35906350	+	In_Frame_Del	DEL	CTG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr9:35906348_35906350delCTG	uc003zyr.1	+	0	160_162	c.64_66delCTG	c.(64-66)ctgdel	p.L28del		NM_001039792	NP_001034881	Q6UXD1	HRCT1_HUMAN	Homo sapiens histidine rich carboxyl terminus 1 (HRCT1), mRNA.	28						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						TGTGGCGGTCctgctgctgctgc	0.670													---	135	---	---	8	---					
ROR2	4920	broad.mit.edu	37	9	94486026	94486028	+	In_Frame_Del	DEL	TCC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr9:94486026_94486028delTCC	uc004arj.2	-	8	2947_2949	c.2748_2750delGGA	c.(2746-2751)gaggaa>gaa	p.916_917EE>E	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	Homo sapiens receptor tyrosine kinase-like orphan receptor 2 (ROR2), mRNA.	916					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|Wnt-protein binding|transmembrane receptor protein tyrosine kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GACAGAGCCTTCCTCCTCCTCCT	0.645													---	623	---	---	9	---					
ANKRD19P	138649	broad.mit.edu	37	9	95599088	95599089	+	RNA	DEL	CA	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr9:95599088_95599089delCA	uc004ass.2	+	8		c.1172_1173delCA			ANKRD19P_uc004asr.4_Non-coding_Transcript					Homo sapiens ankyrin repeat domain 19, pseudogene (ANKRD19P), non-coding RNA.																		TTCACGGGCGCACACACACACA	0.421													---	293	---	---	7	---					
ASTN2	23245	broad.mit.edu	37	9	119976989	119976991	+	In_Frame_Del	DEL	CAG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr9:119976989_119976991delCAG	uc004bjt.2	-	2	762_764	c.661_663delCTG	c.(661-663)ctgdel	p.L221del	ASTN2_uc022bml.1_5'UTR|ASTN2_uc022bmm.1_5'UTR	NM_014010	NP_054729	O75129	ASTN2_HUMAN	Homo sapiens astrotactin 2 (ASTN2), transcript variant 1, mRNA.	221						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CGGTGAACACCAGCAGCAGCAGC	0.601													---	289	---	---	7	---					
TPRN	286262	broad.mit.edu	37	9	140087025	140087027	+	In_Frame_Del	DEL	TCC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr9:140087025_140087027delTCC	uc004clt.3	-	1	1842_1844	c.1842_1844delGGA	c.(1840-1845)gaggaa>gaa	p.614_615EE>E	TPRN_uc004clu.3_In_Frame_Del_p.614_615EE>E	NM_001128228	NP_001121700	Q4KMQ1	TPRN_HUMAN	Homo sapiens taperin (TPRN), mRNA.	614	Glu-rich.				sensory perception of sound	stereocilium		p.E315delE(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						ctcttcctcttcctcctcctcct	0.596													---	129	---	---	7	---					
SYT15	83849	broad.mit.edu	37	10	46969401	46969403	+	In_Frame_Del	DEL	CAG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr10:46969401_46969403delCAG	uc001jea.3	-	1	211_213	c.58_60delCTG	c.(58-60)ctgdel	p.L21del	SYT15_uc001jdz.2_In_Frame_Del_p.L21del|SYT15_uc001jeb.3_Intron|SYT15_uc010qfp.1_5'Flank	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	Homo sapiens synaptotagmin XV (SYT15), transcript variant a, mRNA.	21						integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						CCCCGATCAACAGCAGCAGCAGC	0.631													---	315	---	---	7	---					
FRMPD2	143162	broad.mit.edu	37	10	49409420	49409420	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr10:49409420delT	uc001jgi.3	-	14	2136	c.1805delA	c.(1804-1806)aagfs	p.K602fs	FRMPD2_uc001jgh.3_Frame_Shift_Del_p.K570fs|FRMPD2_uc001jgj.3_Frame_Shift_Del_p.K571fs	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	Homo sapiens FERM and PDZ domain containing 2 (FRMPD2), transcript variant 3, mRNA.	602	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GATGGTGAACTTTTTTTGCTG	0.463													---	861	---	---	7	---					
PLAU	5328	broad.mit.edu	37	10	75673298	75673298	+	Splice_Site	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr10:75673298delA	uc001jwa.3	+	7	607	c.461_splice	c.e7-1	p.G154_splice	C10orf55_uc001jvz.2_Intron|PLAU_uc010qkw.2_Splice_Site_p.G137_splice|PLAU_uc010qkx.2_Splice_Site_p.G68_splice|PLAU_uc001jwb.3_Splice_Site|PLAU_uc001jwc.3_Splice_Site_p.G154_splice|PLAU_uc009xrq.1_Splice_Site_p.G118_splice	NM_002658	NP_002649	P00749	UROK_HUMAN	Homo sapiens plasminogen activator, urokinase (PLAU), transcript variant 1, mRNA.	154	Connecting peptide.				blood coagulation|chemotaxis|fibrinolysis|proteolysis|regulation of cell adhesion mediated by integrin|regulation of receptor activity|regulation of smooth muscle cell migration|regulation of smooth muscle cell-matrix adhesion|signal transduction	cell surface|extracellular space|plasma membrane	serine-type endopeptidase activity			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(3)|ovary(2)	16	Prostate(51;0.0112)				Amiloride(DB00594)|Urokinase(DB00013)	GTCCTCCAGGAAAAAAGCCCT	0.517													---	2046	---	---	7	---					
ZMIZ1	57178	broad.mit.edu	37	10	81072446	81072446	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr10:81072446delC	uc001kaf.2	+	24	3716	c.3144delC	c.(3142-3144)gacfs	p.D1048fs	ZMIZ1_uc001kag.2_Frame_Shift_Del_p.D924fs|ZMIZ1_uc010qlq.1_Frame_Shift_Del_p.D114fs	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	Homo sapiens zinc finger, MIZ-type containing 1 (ZMIZ1), mRNA.	1048					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CTTATCTGGACCCCCCCGACC	0.557													---	1401	---	---	7	---					
SLK	9748	broad.mit.edu	37	10	105727547	105727549	+	In_Frame_Del	DEL	AGA	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr10:105727547_105727549delAGA	uc001kxo.1	+	0	78_80	c.44_46delAGA	c.(43-48)gagaag>gag	p.K19del	SLK_uc001kxp.1_In_Frame_Del_p.K19del	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	Homo sapiens STE20-like kinase (SLK), mRNA.	19	Poly-Lys.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TTGGGGAGCGAGAAGAAGAAGAA	0.448													---	654	---	---	8	---					
OR8I2	120586	broad.mit.edu	37	11	55861308	55861308	+	Frame_Shift_Del	DEL	T	-	-	rs112181516		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr11:55861308delT	uc010rix.2	+	0	525	c.525delT	c.(523-525)catfs	p.H175fs		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	Homo sapiens olfactory receptor, family 8, subfamily I, member 2 (OR8I2), mRNA.	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C178fs*2(1)|p.H175fs*10(1)		NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					GCATCAATCATTTTTTTTGTG	0.443													---	833	---	---	8	---					
DDX10	1662	broad.mit.edu	37	11	108788635	108788637	+	In_Frame_Del	DEL	TGA	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr11:108788635_108788637delTGA	uc001pkm.3	+	16	2405_2407	c.2340_2342delTGA	c.(2338-2343)agtgat>agt	p.D788del	DDX10_uc001pkl.1_In_Frame_Del_p.D788del	NM_004398	NP_004389	Q13206	DDX10_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 (DDX10), mRNA.	788							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TGGATTGGAGtgatgatgatgat	0.355			T	NUP98	AML*								---	402	---	---	7	---					
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	-	-	rs55725290		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr11:124750448_124750453delCGGAGT	uc001qbc.3	+	26	4262_4267	c.4093_4098delCGGAGT	c.(4093-4098)cggagtdel	p.RS1367del	ROBO3_uc001qbd.2_In_Frame_Del_p.RS292del|ROBO3_uc010sar.2_In_Frame_Del_p.RS416del|ROBO3_uc001qbe.3_In_Frame_Del_p.RS292del|ROBO3_uc001qbf.1_In_Frame_Del_p.RS251del	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	Homo sapiens roundabout, axon guidance receptor, homolog 3 (Drosophila) (ROBO3), mRNA.	1367					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.660													---	22	---	---	17	---					
DDX12P	440081	broad.mit.edu	37	12	9573305	9573305	+	RNA	DEL	G	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:9573305delG	uc021qut.1	-	10		c.2093delC			DDX12P_uc001qvx.4_Intron|DDX12P_uc001qvy.1_5'Flank					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene (DDX12P), non-coding RNA.																		gagggagggagggagCCCCCA	0.582													---	140	---	---	13	---					
FAR2	55711	broad.mit.edu	37	12	29450110	29450110	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:29450110delA	uc001rit.3	+	3	790	c.522delA	c.(520-522)ccafs	p.P174fs	FAR2_uc001ris.4_Frame_Shift_Del_p.P174fs|FAR2_uc009zjm.3_Frame_Shift_Del_p.P77fs|AX746523_uc001riu.1_Intron	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	Homo sapiens fatty acyl CoA reductase 2 (FAR2), mRNA.	174					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						CTGTGGAGCCAAAAAAAATCA	0.388													---	796	---	---	13	---					
OR6C75	390323	broad.mit.edu	37	12	55759192	55759192	+	Frame_Shift_Del	DEL	T	-	-	rs75456529		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:55759192delT	uc010spk.2	+	0	298	c.298delT	c.(298-300)tttfs	p.F100fs		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	Homo sapiens olfactory receptor, family 6, subfamily C, member 75 (OR6C75), mRNA.	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						GGCTCAGCTATTTTTTTTCAT	0.438													---	808	---	---	10	---					
MYO1A	4640	broad.mit.edu	37	12	57422572	57422573	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:57422572_57422573insT	uc001smw.4	-	27	3338_3339	c.3098_3099insA	c.(3097-3099)aagfs	p.K1033fs	MYO1A_uc010sqz.2_Frame_Shift_Ins_p.K871fs|MYO1A_uc009zpd.3_Frame_Shift_Ins_p.K1033fs	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	Homo sapiens myosin IA (MYO1A), transcript variant 2, mRNA.	1033					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	ATP binding|actin binding|calmodulin binding|motor activity	p.?(1)		breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						AATGACTCCCCTTTTTTTTGTA	0.559													---	590	---	---	11	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:72094757delT	uc001sws.3	+	5	1576	c.993delT	c.(991-993)ggtfs	p.G331fs		NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	Homo sapiens transmembrane protein 19 (TMEM19), mRNA.	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													---	1020	---	---	9	---					
TMTC3	160418	broad.mit.edu	37	12	88566417	88566417	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:88566417delT	uc001tau.3	+	7	1314	c.1094delT	c.(1093-1095)cttfs	p.L365fs	TMTC3_uc009zsm.2_Non-coding_Transcript	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	Homo sapiens transmembrane and tetratricopeptide repeat containing 3 (TMTC3), mRNA.	365						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						GCATCGAACCTTTTTTTTCCA	0.313													---	713	---	---	13	---					
FBXO21	23014	broad.mit.edu	37	12	117624320	117624320	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:117624320delA	uc001twk.3	-	2	471	c.432delT	c.(430-432)tttfs	p.F144fs	FBXO21_uc001twj.3_Frame_Shift_Del_p.F144fs|FBXO21_uc009zwq.3_Frame_Shift_Del_p.F144fs	NM_033624	NP_296373	O94952	FBX21_HUMAN	Homo sapiens F-box protein 21 (FBXO21), transcript variant 1, mRNA.	144					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity	p.F144fs*9(2)		breast(4)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|pancreas(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	29	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		GTTCATCCTCAAAAAAAATCT	0.373													---	485	---	---	8	---					
SBNO1	55206	broad.mit.edu	37	12	123794283	123794283	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr12:123794283delT	uc010tap.2	-	24	3416	c.3416delA	c.(3415-3417)aatfs	p.N1139fs	SBNO1_uc009zxv.3_Non-coding_Transcript|SBNO1_uc010tao.2_Frame_Shift_Del_p.N1138fs|SBNO1_uc010taq.2_Frame_Shift_Del_p.N90fs|SBNO1_uc001ues.1_Frame_Shift_Del_p.N90fs	NM_001167856	NP_001161328	A3KN83	SBNO1_HUMAN	Homo sapiens strawberry notch homolog 1 (Drosophila) (SBNO1), transcript variant 1, mRNA.	1139							ATP binding|DNA binding|hydrolase activity	p.N1138fs*9(2)		NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		ATATCTTCCATTTTTTTTGGC	0.388													---	706	---	---	13	---					
DKFZp666K117	0	broad.mit.edu	37	13	32527507	32527508	+	RNA	DEL	GT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr13:32527507_32527508delGT	uc001utu.2	+	3		c.1265_1266delGT			DKFZp666K117_uc010tdv.2_Intron|DKFZp666K117_uc001utv.3_Non-coding_Transcript					Homo sapiens eukaryotic translation elongation factor 1 delta pseudogene 3 (EEF1DP3), non-coding RNA.																		TCTGGCCTGAGTGTGTGTGTGT	0.460													---	307	---	---	9	---					
LRP10	26020	broad.mit.edu	37	14	23341527	23341529	+	In_Frame_Del	DEL	CCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr14:23341527_23341529delCCT	uc001whd.3	+	0	568_570	c.15_17delCCT	c.(13-18)accctc>acc	p.L11del	LRP10_uc001whe.3_5'Flank	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 10 (LRP10), mRNA.	11					endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TGTTGGCCACCCTCCTCCTCCTC	0.670													---	558	---	---	8	---					
ACIN1	22985	broad.mit.edu	37	14	23528502	23528503	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr14:23528502_23528503delTC	uc001wit.4	-	18	4208_4209	c.3880_3881delGA	c.(3880-3882)gaafs	p.E1294fs	CDH24_uc001wil.3_5'Flank|CDH24_uc010akf.3_5'Flank|CDH24_uc001win.3_5'Flank|ACIN1_uc001wio.4_Non-coding_Transcript|ACIN1_uc001wip.4_Frame_Shift_Del_p.E536fs|ACIN1_uc001wiq.4_Frame_Shift_Del_p.E536fs|ACIN1_uc001wir.4_Frame_Shift_Del_p.E567fs|ACIN1_uc001wis.4_Frame_Shift_Del_p.E975fs|ACIN1_uc010akg.3_Frame_Shift_Del_p.E1281fs|ACIN1_uc010tnj.2_Frame_Shift_Del_p.E1254fs	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), transcript variant 1, mRNA.	1294	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ccgctccctttctctctctctc	0.629											OREG0022595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	287	---	---	9	---					
HOMEZ	57594	broad.mit.edu	37	14	23745310	23745310	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr14:23745310delA	uc001wja.2	-	1	1275	c.1127delT	c.(1126-1128)ttafs	p.L376fs	HOMEZ_uc001wjb.2_Frame_Shift_Del_p.L378fs	NM_020834	NP_065885	Q8IX15	HOMEZ_HUMAN	Homo sapiens homeobox and leucine zipper encoding (HOMEZ), mRNA.	376						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.L376fs*14(1)		endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CTGGCACTGTAAAAAAAAGGA	0.488													---	322	---	---	7	---					
FBXO33	254170	broad.mit.edu	37	14	39871612	39871612	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr14:39871612delT	uc001wvk.3	-	1	1041	c.703delA	c.(703-705)attfs	p.I235fs		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	Homo sapiens F-box protein 33 (FBXO33), mRNA.	235										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|urinary_tract(1)	9	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		TACTGTTTAATTTTTTTGCCA	0.323													---	272	---	---	7	---					
SIPA1L1	26037	broad.mit.edu	37	14	72190482	72190484	+	In_Frame_Del	DEL	TCC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr14:72190482_72190484delTCC	uc001xms.3	+	15	4751_4753	c.4390_4392delTCC	c.(4390-4392)tccdel	p.S1468del	SIPA1L1_uc001xmt.3_In_Frame_Del_p.S1447del|SIPA1L1_uc001xmu.3_In_Frame_Del_p.S1447del|SIPA1L1_uc001xmv.3_In_Frame_Del_p.S1468del|SIPA1L1_uc010ttm.2_In_Frame_Del_p.S922del	NM_015556	NP_056371	O43166	SI1L1_HUMAN	Homo sapiens signal-induced proliferation-associated 1 like 1 (SIPA1L1), mRNA.	1468	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ctcctcctcttcctcctcctcct	0.552													---	801	---	---	8	---					
HERC2	8924	broad.mit.edu	37	15	28515875	28515876	+	Frame_Shift_Ins	INS	-	TC	TC			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr15:28515875_28515876insTC	uc001zbj.3	-	9	1328_1329	c.1222_1223insGA	c.(1222-1224)atgfs	p.M408fs	HERC2_uc001zbl.1_Frame_Shift_Ins_p.M103fs	NM_004667	NP_004658	O95714	HERC2_HUMAN	Homo sapiens hect domain and RLD 2 (HERC2), mRNA.	408					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAGCGGAGGCATACAGGGCGTA	0.515													---	385	---	---	9	---					
SPATA5L1	79029	broad.mit.edu	37	15	45710840	45710841	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr15:45710840_45710841insT	uc001zve.3	+	6	2163_2164	c.2054_2055insT	c.(2053-2055)tgtfs	p.C685fs	SPATA5L1_uc001zvf.3_Non-coding_Transcript	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	Homo sapiens spermatogenesis associated 5-like 1 (SPATA5L1), transcript variant 1, mRNA.	685						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GCAGAAACCTGTTTTTTTTCTG	0.361													---	426	---	---	8	---					
TCF12	6938	broad.mit.edu	37	15	57489984	57489984	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr15:57489984delA	uc002aec.3	+	7	824	c.540delA	c.(538-540)gcafs	p.A180fs	TCF12_uc010ugm.1_Frame_Shift_Del_p.A232fs|TCF12_uc010ugn.1_Frame_Shift_Del_p.A176fs|TCF12_uc002aea.3_Frame_Shift_Del_p.A180fs|TCF12_uc010bfs.3_Intron|TCF12_uc002aeb.3_Frame_Shift_Del_p.A180fs|TCF12_uc002aed.3_Frame_Shift_Del_p.A180fs	NM_207038	NP_996921	Q99081	HTF4_HUMAN	Homo sapiens transcription factor 12 (TCF12), transcript variant 4, mRNA.	180					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CCTTGCAAGCAAAAAAAGTCA	0.343			T	TEC	extraskeletal myxoid chondrosarcoma								---	541	---	---	10	---					
SLTM	79811	broad.mit.edu	37	15	59182525	59182526	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr15:59182525_59182526delTC	uc002afp.3	-	14	2121_2122	c.2033_2034delGA	c.(2032-2034)agafs	p.R678fs	SLTM_uc002afn.3_Frame_Shift_Del_p.R220fs|SLTM_uc002afo.3_Frame_Shift_Del_p.R660fs|SLTM_uc002afq.3_Frame_Shift_Del_p.R247fs|SLTM_uc010bgd.3_Frame_Shift_Del_p.R247fs	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	Homo sapiens SAFB-like, transcription modulator (SLTM), transcript variant 1, mRNA.	678	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	RNA binding|nucleotide binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGCGTTCCATTCTCTCTCTCTC	0.431													---	928	---	---	12	---					
KIAA1024	23251	broad.mit.edu	37	15	79750586	79750586	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr15:79750586delA	uc002bew.1	+	1	2172	c.2097delA	c.(2095-2097)ttafs	p.L699fs	KIAA1024_uc010unk.1_Frame_Shift_Del_p.L699fs	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	Homo sapiens KIAA1024 (KIAA1024), mRNA.	699						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						TCAAGGCCTTAAAAAAAAGCC	0.542													---	773	---	---	8	---					
SLC9A5	6553	broad.mit.edu	37	16	67300017	67300019	+	In_Frame_Del	DEL	GAG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr16:67300017_67300019delGAG	uc002esm.3	+	14	2170_2172	c.2107_2109delGAG	c.(2107-2109)gagdel	p.E708del	SLC9A5_uc010cee.3_In_Frame_Del_p.E413del|SLC9A5_uc010vji.2_In_Frame_Del_p.E212del	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 5 (SLC9A5), mRNA.	708					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CGTGGAGTCTGAGGAGGAGGAGG	0.571													---	333	---	---	14	---					
SLC7A6	9057	broad.mit.edu	37	16	68330539	68330539	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr16:68330539delT	uc002evt.2	+	10	1592	c.1279delT	c.(1279-1281)tttfs	p.F427fs	SLC7A6_uc002evv.2_Non-coding_Transcript|SLC7A6_uc002evu.2_Frame_Shift_Del_p.F427fs|SLC7A6_uc010cfc.1_Non-coding_Transcript	NM_001076785	NP_003974	Q92536	YLAT2_HUMAN	Homo sapiens solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 (SLC7A6), transcript variant 1, mRNA.	427					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		GCTGAGCGTGTTTTTCCCCAT	0.522													---	1203	---	---	7	---					
MYH10	4628	broad.mit.edu	37	17	8397095	8397097	+	In_Frame_Del	DEL	CCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr17:8397095_8397097delCCT	uc002glm.3	-	31	4259_4261	c.4163_4165delAGG	c.(4162-4167)gaggcc>gcc	p.E1388del	MYH10_uc002gll.3_In_Frame_Del_p.E1357del|MYH10_uc010cnx.3_In_Frame_Del_p.E1366del	NM_005964	NP_005955	P35580	MYH10_HUMAN	Homo sapiens myosin, heavy chain 10, non-muscle (MYH10), transcript variant 2, mRNA.	1357					actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	ADP binding|ATP binding|actin filament binding|actin-dependent ATPase activity|calmodulin binding|microfilament motor activity	p.E1388G(1)		breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						TTCTTCCTGGCCTCCTCCTCCTC	0.596													---	310	---	---	7	---					
PLCD3	113026	broad.mit.edu	37	17	43192760	43192762	+	In_Frame_Del	DEL	TCC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr17:43192760_43192762delTCC	uc002iib.3	-	8	1623_1625	c.1509_1511delGGA	c.(1507-1512)gaggat>gat	p.E503del		NM_133373	NP_588614	Q8N3E9	PLCD3_HUMAN	Homo sapiens phospholipase C, delta 3 (PLCD3), mRNA.	503					intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.E503D(3)		breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	ctcctcgtcatcctcctcctcct	0.670													---	85	---	---	8	---					
SOGA2	23255	broad.mit.edu	37	18	8793004	8793004	+	Frame_Shift_Del	DEL	C	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr18:8793004delC	uc002knr.2	+	7	2038	c.1896delC	c.(1894-1896)ggcfs	p.G632fs	SOGA2_uc002knq.2_Intron|SOGA2_uc002kns.2_Intron	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	Homo sapiens coiled-coil domain containing 165 (CCDC165), mRNA.	980																	AGCTCAGGGGCCCCCCCGTTT	0.552													---	1095	---	---	7	---					
MBD3	53615	broad.mit.edu	37	19	1578372	1578374	+	In_Frame_Del	DEL	CTC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:1578372_1578374delCTC	uc002ltj.3	-	5	863_865	c.841_843delGAG	c.(841-843)gagdel	p.E281del	AX747577_uc002lti.1_5'Flank|MBD3_uc002ltk.3_In_Frame_Del_p.E249del|MBD3_uc002ltl.1_In_Frame_Del_p.E281del	NM_003926	NP_003917	O95983	MBD3_HUMAN	Homo sapiens methyl-CpG binding domain protein 3 (MBD3), mRNA.	281	Poly-Glu.				transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	8		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGTCGGGctcctcctcctcc	0.714													---	193	---	---	8	---					
TNFSF9	8744	broad.mit.edu	37	19	6531149	6531151	+	In_Frame_Del	DEL	GCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:6531149_6531151delGCT	uc002mfh.2	+	0	140_142	c.102_104delGCT	c.(100-105)gggctg>ggg	p.L41del		NM_003811	NP_003802	P41273	TNFL9_HUMAN	Homo sapiens tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9), mRNA.	41	Poly-Leu.				apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						TGGTCGCGGGgctgctgctgctg	0.768													---	289	---	---	9	---					
TSHZ3	57616	broad.mit.edu	37	19	31769141	31769142	+	Frame_Shift_Ins	INS	-	C	C			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:31769141_31769142insC	uc002nsy.4	-	1	1622_1623	c.1557_1558insG	c.(1555-1560)gggcttfs	p.G519fs		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	Homo sapiens teashirt zinc finger homeobox 3 (TSHZ3), mRNA.	519					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGGATATCAAGCCCCCCCTTGG	0.500													---	1212	---	---	8	---					
HAMP	57817	broad.mit.edu	37	19	35773520	35773522	+	In_Frame_Del	DEL	CTC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:35773520_35773522delCTC	uc002nyw.3	+	0	111_113	c.40_42delCTC	c.(40-42)ctcdel	p.L18del		NM_021175	NP_066998	P81172	HEPC_HUMAN	Homo sapiens hepcidin antimicrobial peptide (HAMP), mRNA.	18					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGCCTCCTGCTCCTCCTCCTCC	0.640													---	964	---	---	13	---					
PRX	57716	broad.mit.edu	37	19	40900180	40900182	+	In_Frame_Del	DEL	TCC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:40900180_40900182delTCC	uc002onr.3	-	6	4346_4348	c.4077_4079delGGA	c.(4075-4080)gaggaa>gaa	p.1359_1360EE>E	PRX_uc002onq.3_In_Frame_Del_p.1220_1221EE>E|PRX_uc002ons.3_3'UTR	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	Homo sapiens periaxin (PRX), transcript variant 2, mRNA.	1359	Poly-Glu.		Missing.		axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACTGCcctcttcctcctcctcct	0.695													---	144	---	---	8	---					
ERF	2077	broad.mit.edu	37	19	42753149	42753151	+	In_Frame_Del	DEL	GAA	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:42753149_42753151delGAA	uc002ote.4	-	3	1271_1273	c.1113_1115delTTC	c.(1111-1116)tcttcc>tcc	p.371_372SS>S	ERF_uc002otd.4_In_Frame_Del_p.102_103SS>S	NM_006494	NP_006485	P50548	ERF_HUMAN	Homo sapiens Ets2 repressor factor (ERF), mRNA.	371	Poly-Ser.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				GAATGGGGAGGAAGAAGAAGAAG	0.680													---	600	---	---	7	---					
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	-	-	rs62639328	byFrequency	TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:46299165_46299167delCCT	uc002pdm.3	-	5	2285_2287	c.2114_2116delAGG	c.(2113-2118)gagggc>ggc	p.E705del	RSPH6A_uc002pdl.3_In_Frame_Del_p.E441del	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	Homo sapiens radial spoke head 6 homolog A (Chlamydomonas) (RSPH6A), mRNA.	705	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tcctcctcgccctcctcctcctc	0.586													---	974	---	---	14	---					
FLT3LG	2323	broad.mit.edu	37	19	49978960	49978962	+	In_Frame_Del	DEL	CTG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:49978960_49978962delCTG	uc002pnu.3	+	2	156_158	c.46_48delCTG	c.(46-48)ctgdel	p.L20del	FLT3LG_uc002pnw.3_5'UTR|FLT3LG_uc010yau.2_In_Frame_Del_p.L20del|FLT3LG_uc002pnv.3_5'UTR|FLT3LG_uc002pnx.3_In_Frame_Del_p.L20del|FLT3LG_uc010yav.2_5'UTR	NM_001459	NP_001450	P49771	FLT3L_HUMAN	Homo sapiens fms-related tyrosine kinase 3 ligand (FLT3LG), transcript variant 3, mRNA.	20					positive regulation of cell proliferation|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity			large_intestine(2)|lung(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	10		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		CTATCTCCTCCTGCTGCTGCTGC	0.621													---	397	---	---	8	---					
FUZ	80199	broad.mit.edu	37	19	50310483	50310485	+	In_Frame_Del	DEL	CAG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr19:50310483_50310485delCAG	uc002ppq.2	-	10	1384_1386	c.1180_1182delCTG	c.(1180-1182)ctgdel	p.L394del	FUZ_uc002ppt.2_Non-coding_Transcript|FUZ_uc002ppu.2_In_Frame_Del_p.L358del	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	Homo sapiens fuzzy homolog (Drosophila) (FUZ), transcript variant 1, mRNA.	394	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TCTGGGGAGACAGCAGCAGCAGC	0.635													---	293	---	---	11	---					
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	-	-	rs138961929		TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr20:4850569delG	uc002wlg.1	-	11	1608	c.1233delC	c.(1231-1233)cccfs	p.P411fs	SLC23A2_uc010zqr.1_Frame_Shift_Del_p.P296fs|SLC23A2_uc002wlh.1_Frame_Shift_Del_p.P411fs|SLC23A2_uc002wli.3_Frame_Shift_Del_p.P410fs	NM_005116	NP_976072	Q9UGH3	S23A2_HUMAN	Homo sapiens solute carrier family 23 (nucleobase transporters), member 2 (SLC23A2), transcript variant 1, mRNA.	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity	p.I412fs*4(1)		endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTGCGTGGATGGGGGGGGGTG	0.527													---	533	---	---	19	---					
DSTN	11034	broad.mit.edu	37	20	17581679	17581680	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr20:17581679_17581680insT	uc002wpr.3	+	1	555_556	c.300_301insT	c.(298-303)atgtttfs	p.M100fs	DSTN_uc002wpq.3_Frame_Shift_Ins_p.M83fs|DSTN_uc010gck.3_Frame_Shift_Ins_p.M83fs	NM_006870	NP_001011546	P60981	DEST_HUMAN	Homo sapiens destrin (actin depolymerizing factor) (DSTN), transcript variant 1, mRNA.	100	ADF-H.				actin filament severing|actin polymerization or depolymerization		actin binding			endometrium(1)|large_intestine(5)|lung(8)|skin(1)	15						AAGAGTTGATGTTTTTTTTGTG	0.356													---	430	---	---	8	---					
ANKRD30BP2	149992	broad.mit.edu	37	21	14439225	14439226	+	RNA	INS	-	A	A			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr21:14439225_14439226insA	uc002yja.4	+	9		c.2743_2744insA								Homo sapiens ankyrin repeat domain 30B pseudogene 2 (ANKRD30BP2), non-coding RNA.																		TATATTAAATGAAAAATTAGGG	0.287													---	86	---	---	12	---					
PLA2G3	50487	broad.mit.edu	37	22	31536134	31536135	+	Frame_Shift_Ins	INS	-	T	T			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr22:31536134_31536135insT	uc003aka.3	-	0	335_336	c.206_207insA	c.(205-207)cagfs	p.Q69fs		NM_015715	NP_056530	Q9NZ20	PA2G3_HUMAN	Homo sapiens phospholipase A2, group III (PLA2G3), mRNA.	69					cilium morphogenesis|lipid catabolic process|phospholipid metabolic process	centriole|extracellular space|plasma membrane	calcium ion binding|calcium-dependent phospholipase A2 activity			large_intestine(1)|lung(10)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	18						AGCTACATGACTGCAGCCTCCT	0.649													---	565	---	---	7	---					
PICK1	9463	broad.mit.edu	37	22	38471034	38471036	+	In_Frame_Del	DEL	GGA	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr22:38471034_38471036delGGA	uc003auq.3	+	12	1533_1535	c.1143_1145delGGA	c.(1141-1146)ggggag>ggg	p.E388del	PICK1_uc003aur.3_In_Frame_Del_p.E388del|PICK1_uc003aus.3_In_Frame_Del_p.E388del|PICK1_uc003aut.3_In_Frame_Del_p.E388del	NM_012407	NP_036539	Q9NRD5	PICK1_HUMAN	Homo sapiens protein interacting with PRKCA 1 (PICK1), transcript variant 1, mRNA.	388	Poly-Glu.				DNA methylation involved in embryo development|DNA methylation involved in gamete generation|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	Golgi apparatus|cell junction|endocytic vesicle membrane|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					TCACAGATGGggaggaggaggag	0.635													---	147	---	---	7	---					
ARFGAP3	26286	broad.mit.edu	37	22	43218401	43218401	+	Frame_Shift_Del	DEL	T	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chr22:43218401delT	uc003bdd.2	-	8	907	c.687delA	c.(685-687)aaafs	p.K229fs	ARFGAP3_uc010gzf.2_Frame_Shift_Del_p.K185fs|ARFGAP3_uc011apu.1_Frame_Shift_Del_p.K157fs	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	Homo sapiens ADP-ribosylation factor GTPase activating protein 3 (ARFGAP3), transcript variant 1, mRNA.	229					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|cytosol	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	11						CCAAACTTCCTTTTTTGGCCC	0.423													---	794	---	---	7	---					
ATRX	546	broad.mit.edu	37	X	76907782	76907784	+	In_Frame_Del	DEL	TCC	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrX:76907782_76907784delTCC	uc004ecp.4	-	14	4609_4611	c.4377_4379delGGA	c.(4375-4380)gaggaa>gaa	p.1459_1460EE>E	ATRX_uc004ecq.4_In_Frame_Del_p.1421_1422EE>E|ATRX_uc004eco.4_In_Frame_Del_p.1244_1245EE>E	NM_000489	NP_000480	P46100	ATRX_HUMAN	Homo sapiens alpha thalassemia/mental retardation syndrome X-linked (ATRX), transcript variant 1, mRNA.	1459	Poly-Glu.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|DNA binding|DNA helicase activity|chromo shadow domain binding|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	ctcctcctcttcctcctcctcct	0.389			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						---	351	---	---	7	---					
MAMLD1	10046	broad.mit.edu	37	X	149639325	149639327	+	In_Frame_Del	DEL	CAG	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrX:149639325_149639327delCAG	uc011mxu.2	+	2	1715_1717	c.1405_1407delCAG	c.(1405-1407)cagdel	p.Q477del	MAMLD1_uc011mxt.1_In_Frame_Del_p.Q464del|MAMLD1_uc004fee.2_In_Frame_Del_p.Q502del|MAMLD1_uc011mxv.2_In_Frame_Del_p.Q477del|MAMLD1_uc011mxw.2_In_Frame_Del_p.Q429del	NM_001177465	NP_001170936	Q13495	MAMD1_HUMAN	Homo sapiens mastermind-like domain containing 1 (MAMLD1), transcript variant 1, mRNA.	502					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.Q469Q(1)|p.Q494Q(1)|p.Q421Q(1)		breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCcagcaacagcagcagcagc	0.532													---	231	---	---	9	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrX:150817142_150817144delGCT	uc004fev.4	+	8	1017_1019	c.685_687delGCT	c.(685-687)gctdel	p.A236del		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	Homo sapiens PAS domain containing 1 (PASD1), mRNA.	236	Poly-Ala.					nucleus	signal transducer activity	p.A229A(2)|p.A235D(1)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.433													---	446	---	---	13	---					
RPL10	6134	broad.mit.edu	37	X	153627860	153627860	+	Frame_Shift_Del	DEL	A	-	-			TCGA-F2-7273-01A-11D-2154-08	TCGA-F2-7273-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c3063058-e144-41a9-86f7-6e7a637bb797	fcff255b-3e83-4128-884c-2ec890589827	g.chrX:153627860delA	uc004fkm.2	+	3	303	c.115delA	c.(115-117)aaafs	p.K39fs	AK307233_uc010nuv.2_5'Flank|RPL10_uc004fko.2_Frame_Shift_Del_p.K39fs|RPL10_uc004fkn.1_Frame_Shift_Del_p.K39fs|RPL10_uc004fkq.1_Non-coding_Transcript|RPL10_uc004fkr.1_5'Flank|SNORA70_uc010nux.1_5'Flank|RPL10_uc022cif.1_5'Flank	NM_006013	NP_006004	P27635	RL10_HUMAN	Homo sapiens ribosomal protein L10 (RPL10), transcript variant 1, mRNA.	39					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|endoplasmic reticulum	structural constituent of ribosome			large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCTGGGGCGGAAAAAGGCAAA	0.512											OREG0019957	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	644	---	---	7	---					
