Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DFFB	1677	broad.mit.edu	37	1	3775314	3775314	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:3775314C>T	uc001alc.2	+	2	470	c.147C>T	c.(145-147)TAC>TAT	p.Y49Y	DFFB_uc001ale.2_RNA|DFFB_uc009vlp.2_RNA|DFFB_uc001alb.2_RNA|DFFB_uc010nzn.1_Silent_p.Y49Y|DFFB_uc009vlq.2_RNA|DFFB_uc009vlr.2_Translation_Start_Site|DFFB_uc001ald.2_Translation_Start_Site|KIAA0562_uc001aky.2_5'Flank|KIAA0562_uc010nzm.1_5'Flank|KIAA0562_uc001akz.2_5'Flank|DFFB_uc009vln.1_Silent_p.Y49Y|DFFB_uc001ala.1_Silent_p.Y49Y|DFFB_uc009vlo.1_Silent_p.Y49Y	NM_004402	NP_004393	O76075	DFFB_HUMAN	DNA fragmentation factor, 40 kD, beta	49	CIDE-N.				apoptotic chromosome condensation|DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction	cytosol|nucleoplasm	deoxyribonuclease activity|enzyme binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;2.05e-30)|all_epithelial(116;6.22e-21)|all_lung(118;2.65e-08)|Lung NSC(185;6.25e-06)|Breast(487;0.000659)|Renal(390;0.00121)|all_neural(13;0.0019)|Hepatocellular(190;0.00705)|Colorectal(325;0.0113)|all_hematologic(16;0.0194)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0548)|Medulloblastoma(700;0.211)		Epithelial(90;1.18e-39)|OV - Ovarian serous cystadenocarcinoma(86;7.28e-23)|GBM - Glioblastoma multiforme(42;2.95e-17)|Colorectal(212;1.23e-05)|COAD - Colon adenocarcinoma(227;5.94e-05)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00038)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		TGTGCCTGTACGAGGATGGCA	0.632000													9	66					0	0	0.047766	0	0
EIF2C1	26523	broad.mit.edu	37	1	36372633	36372633	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:36372633G>A	uc001bzl.2	+	12	1708	c.1495G>A	c.(1495-1497)GTG>ATG	p.V499M	EIF2C1_uc001bzk.2_Missense_Mutation_p.V424M|EIF2C1_uc009vuy.2_RNA	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	499					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGCAGACAGCGTGGAGCCTAT	0.532000													37	72					0	0	0.064281	0	0
MUTYH	4595	broad.mit.edu	37	1	45797852	45797852	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:45797852G>A	uc001cnm.2	-	10	1126	c.910C>T	c.(910-912)CGG>TGG	p.R304W	MUTYH_uc009vxn.2_Missense_Mutation_p.R129W|MUTYH_uc001cnf.2_Missense_Mutation_p.R279W|MUTYH_uc009vxo.2_Missense_Mutation_p.R279W|MUTYH_uc001cng.2_Missense_Mutation_p.R290W|MUTYH_uc001cnj.2_Missense_Mutation_p.R187W|MUTYH_uc001cni.2_Missense_Mutation_p.R279W|MUTYH_uc001cnh.2_Missense_Mutation_p.R280W|MUTYH_uc001cno.2_Missense_Mutation_p.R187W|MUTYH_uc001cnk.2_Missense_Mutation_p.R164W|MUTYH_uc010oll.1_Intron|MUTYH_uc001cnl.2_Missense_Mutation_p.R293W|MUTYH_uc009vxp.2_Missense_Mutation_p.R307W|MUTYH_uc001cnn.2_Missense_Mutation_p.R294W	NM_012222	NP_036354	Q9UIF7	MUTYH_HUMAN	mutY homolog isoform 1	304					depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding				0	Acute lymphoblastic leukemia(166;0.155)					TGGCGTGCCCGGCACAGGCTC	0.617000			Mis			colorectal		BER_DNA_glycosylases	MUTYH-associated_polyposis				7	80					0	0	0.038147	0	0
SLC5A9	200010	broad.mit.edu	37	1	48703474	48703474	+	Silent	SNP	C	T	T	rs141985089		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:48703474C>T	uc001cro.2	+	11	1468	c.1416C>T	c.(1414-1416)ACC>ACT	p.T472T	SLC5A9_uc010oms.1_RNA|SLC5A9_uc001crn.2_Silent_p.T497T|SLC5A9_uc010omt.1_Silent_p.T486T|SLC5A9_uc001crp.2_Silent_p.T139T|SLC5A9_uc010omu.1_Silent_p.T139T|SLC5A9_uc009vyt.1_5'Flank	NM_001011547	NP_001011547	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/glucose	472	Helical; (Potential).					integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			ovary(3)	3						CACCCATCACCGCTCTCTTCC	0.512000													4	43					0	0	0.150653	0	0
EVI5	7813	broad.mit.edu	37	1	93167736	93167736	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:93167736G>C	uc001dox.2	-	5	743	c.733C>G	c.(733-735)CAA>GAA	p.Q245E	EVI5_uc010otf.1_Missense_Mutation_p.Q245E	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	245	Dimerization.|Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Rab-GAP TBC.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GCACTTCCTTGACAGTAACCA	0.308000													3	62					0	0	0.115264	0	0
NGF	4803	broad.mit.edu	37	1	115829246	115829246	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:115829246C>T	uc001efu.1	-	3	340	c.171G>A	c.(169-171)GCG>GCA	p.A57A		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	57					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CAGCTATCGCCGCTGCCGGGG	0.617000													11	28					0	0	0.160694	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783718	149783718	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:149783718C>T	uc001esr.2	-	1	211	c.161G>A	c.(160-162)GGC>GAC	p.G54D	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.G54D|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.G54D	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	54					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					GGACGAGATGCCGGTGTCGGG	0.597000													5	234					0	0	0.014758	0	0
MRPS21	54460	broad.mit.edu	37	1	150280628	150280628	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:150280628G>A	uc001euk.2	+	3	312	c.230G>A	c.(229-231)CGA>CAA	p.R77Q	MRPS21_uc001eul.2_Missense_Mutation_p.R77Q	NM_031901	NP_114107	P82921	RT21_HUMAN	mitochondrial ribosomal protein S21	77					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	Lung NSC(24;5.57e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTCTTGATGCGAAAGAATCGG	0.527000													5	43					0	0	0.014758	0	0
SCNM1	79005	broad.mit.edu	37	1	151140660	151140660	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:151140660C>T	uc001ewz.2	+	6	551	c.439C>T	c.(439-441)CCA>TCA	p.P147S	LYSMD1_uc001ewy.2_5'Flank|LYSMD1_uc010pcr.1_5'Flank|SCNM1_uc009wmn.2_RNA	NM_024041	NP_076946	Q9BWG6	SCNM1_HUMAN	sodium channel modifier 1	147					mRNA processing|RNA splicing	nucleus	metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTCCCCTATGCCACCCTCAGA	0.552000													6	455					0	0	0.021553	0	0
BCAN	63827	broad.mit.edu	37	1	156617459	156617459	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:156617459C>T	uc001fpp.2	+	4	962	c.626C>T	c.(625-627)TCG>TTG	p.S209L	BCAN_uc001fpo.2_Missense_Mutation_p.S209L	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	209	Link 1.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCTGGCTGTCGGATCAGACC	0.647000													45	63					0	0	0.139131	0	0
STX6	10228	broad.mit.edu	37	1	180974431	180974431	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:180974431G>C	uc010pnq.1	-	2	441	c.204C>G	c.(202-204)ATC>ATG	p.I68M	STX6_uc001goo.2_Missense_Mutation_p.I68M|STX6_uc010pnr.1_Intron	NM_005819	NP_005810	O43752	STX6_HUMAN	syntaxin 6	68	Potential.|Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|vesicle fusion	clathrin-coated vesicle|early endosome|integral to membrane|perinuclear region of cytoplasm|plasma membrane|trans-Golgi network membrane	SNAP receptor activity			ovary(1)	1						AAAGGATATTGATGGTTTCAT	0.423000													28	201					0	0	0.125774	0	0
CACNA1E	777	broad.mit.edu	37	1	181745324	181745324	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:181745324G>A	uc001gow.2	+	38	5392	c.5227G>A	c.(5227-5229)GAG>AAG	p.E1743K	CACNA1E_uc009wxs.2_Missense_Mutation_p.E1631K|CACNA1E_uc001gox.1_Missense_Mutation_p.E969K|CACNA1E_uc009wxt.2_Missense_Mutation_p.E969K	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1743	EF-hand.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CCACTTGGACGAGTTTGTCCG	0.607000													23	162					0	0	0.099896	0	0
SUSD4	55061	broad.mit.edu	37	1	223396682	223396682	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:223396682C>T	uc001hnx.2	-	7	1987	c.1353G>A	c.(1351-1353)GAG>GAA	p.E451E	SUSD4_uc001hny.3_Silent_p.E451E|SUSD4_uc010puw.1_Silent_p.E291E	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	451	Cytoplasmic (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		GGTGGGTGCTCTCTTGGCACC	0.582000													11	69					0	0	0.069234	0	0
CHML	1122	broad.mit.edu	37	1	241798676	241798676	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:241798676G>A	uc001hzd.2	-	1	557	c.393C>T	c.(391-393)TTC>TTT	p.F131F	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	131					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			GAACTTCAGTGAAGGTATTAG	0.423000													9	315					0	0	0.047766	0	0
ITIH2	3698	broad.mit.edu	37	10	7745454	7745454	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:7745454C>T	uc001ijs.2	+	1	219	c.57C>T	c.(55-57)TTC>TTT	p.F19F		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	19					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TATCAGGCTTCGAAATCCCCA	0.418000													10	118					0	0	0.080935	0	0
RASGEF1A	221002	broad.mit.edu	37	10	43692548	43692548	+	Splice_Site	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:43692548C>T	uc001jap.1	-	11	1306	c.1225_splice	c.e11-1	p.K409_splice	RASGEF1A_uc001jao.1_Splice_Site_p.K417_splice	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A						cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						CCCAGAATTTCTGAAGGGAGC	0.498000													47	66					0	0	0.139131	0	0
KIAA1279	26128	broad.mit.edu	37	10	70748636	70748636	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:70748636G>A	uc001joy.2	+	1	144	c.48G>A	c.(46-48)GCG>GCA	p.A16A		NM_015634	NP_056449	Q96EK5	KBP_HUMAN	KIF1 binding protein	16					cell differentiation|mitochondrial transport|nervous system development	mitochondrion	kinesin binding			ovary(1)	1						TCCAGGCGGCGCTCGCTCTGT	0.592000											OREG0020215	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	70					0	0	0.150653	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105372776	105372776	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:105372776G>A	uc001kxj.1	-	11	1148	c.1008C>T	c.(1006-1008)GCC>GCT	p.A336A	SH3PXD2A_uc010qqr.1_Silent_p.A226A|SH3PXD2A_uc010qqs.1_Silent_p.A171A|SH3PXD2A_uc010qqt.1_Silent_p.A213A|SH3PXD2A_uc009xxn.1_Silent_p.A171A|SH3PXD2A_uc010qqu.1_Silent_p.A279A	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	364					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		CCTCGCCTTCGGCTGGTGGAG	0.587000													45	33					0	0	0.117977	0	0
TCERG1L	256536	broad.mit.edu	37	10	132965127	132965127	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:132965127C>G	uc001lkp.2	-	5	964	c.878G>C	c.(877-879)CGA>CCA	p.R293P	TCERG1L_uc009yax.1_RNA	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	293										large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		GCGGGCCACTCGGCCCCGCTC	0.512000													3	30					0	0	0.150653	0	0
PWWP2B	170394	broad.mit.edu	37	10	134219456	134219456	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:134219456C>T	uc001lll.3	+	2	1481	c.1452C>T	c.(1450-1452)GAC>GAT	p.D484D	PWWP2B_uc009ybe.2_Silent_p.D484D	NM_138499	NP_612508	Q6NUJ5	PWP2B_HUMAN	PWWP domain containing 2 isoform 1	484											0		all_cancers(35;6.69e-12)|all_epithelial(44;1.55e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.109)|Melanoma(40;0.123)|Glioma(114;0.203)|all_hematologic(284;0.224)		OV - Ovarian serous cystadenocarcinoma(35;7.49e-05)|Epithelial(32;0.00016)|all cancers(32;0.000186)		TCACGGAGGACGGCAGGACTG	0.647000													4	71					0	0	0.014758	0	0
DCHS1	8642	broad.mit.edu	37	11	6651131	6651131	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr11:6651131C>T	uc001mem.1	-	11	5217	c.4807G>A	c.(4807-4809)GTG>ATG	p.V1603M		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1603	Cadherin 15.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCGCACCACGGACAGCGCT	0.652000													10	27					0	0	0.119110	0	0
MARK2	2011	broad.mit.edu	37	11	63670179	63670179	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr11:63670179C>T	uc001nxw.2	+	13	1920	c.1341C>T	c.(1339-1341)GCC>GCT	p.A447A	MARK2_uc001nxx.2_Silent_p.A447A|MARK2_uc001nxy.2_Silent_p.A446A|MARK2_uc001nxv.3_Silent_p.A446A|MARK2_uc001nxz.3_Silent_p.A413A|MARK2_uc009yoy.2_Silent_p.A413A	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	447					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						GGCGGAAAGCCAGCAGCACAG	0.612000													4	22					0	0	0.150653	0	0
PDGFD	80310	broad.mit.edu	37	11	104034556	104034556	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr11:104034556G>A	uc001phq.2	-	1	472	c.100C>T	c.(100-102)CGC>TGC	p.R34C	PDGFD_uc001php.2_Missense_Mutation_p.R34C	NM_025208	NP_079484	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D isoform 1	34					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			upper_aerodigestive_tract(1)|large_intestine(1)	2		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TTGGCGTTGCGCAAAGCTTTG	0.423000											OREG0021315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	28					0	0	0.115264	0	0
ITPR2	3709	broad.mit.edu	37	12	26592082	26592082	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr12:26592082C>A	uc001rhg.2	-	47	7038	c.6621G>T	c.(6619-6621)ATG>ATT	p.M2207I	ITPR2_uc009zjg.1_Missense_Mutation_p.M358I	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2207	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCTGCCACTTCATTTCATTGT	0.383000													11	187					4.3838e-07	4.5508e-07	0.105934	1	0
FAM186B	84070	broad.mit.edu	37	12	49994424	49994424	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr12:49994424C>T	uc001ruo.2	-	4	1172	c.999G>A	c.(997-999)GAG>GAA	p.E333E	FAM186B_uc010smk.1_Silent_p.E243E	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	333						protein complex				ovary(1)	1						CAACAGAAACCTCAGCCAGGT	0.537000													75	114					0	0	0.139131	0	0
SMARCC2	6601	broad.mit.edu	37	12	56575341	56575341	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr12:56575341C>A	uc001skb.2	-	10	987	c.881G>T	c.(880-882)GGA>GTA	p.G294V	SMARCC2_uc001skd.2_Missense_Mutation_p.G294V|SMARCC2_uc001ska.2_Missense_Mutation_p.G294V|SMARCC2_uc001skc.2_Missense_Mutation_p.G294V|SMARCC2_uc010sqf.1_Missense_Mutation_p.G183V	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	294					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CTTATAGTTTCCCCCCTTCTT	0.512000													13	104					0.000151284	0.000154112	0.105934	1	0
CAND1	55832	broad.mit.edu	37	12	67692752	67692752	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr12:67692752C>T	uc001stn.2	+	7	1314	c.877C>T	c.(877-879)CAT>TAT	p.H293Y	CAND1_uc001sto.2_5'UTR	NM_018448	NP_060918	Q86VP6	CAND1_HUMAN	TIP120 protein	293	HEAT 8.				cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		AGTATATCCTCATGTTTCTAC	0.249000													7	67					0	0	0.029380	0	0
OSBPL8	114882	broad.mit.edu	37	12	76778126	76778126	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr12:76778126G>A	uc001sye.1	-	15	2018	c.1538C>T	c.(1537-1539)TCC>TTC	p.S513F	OSBPL8_uc001syf.1_Missense_Mutation_p.S471F|OSBPL8_uc001syg.1_Missense_Mutation_p.S471F|OSBPL8_uc001syh.1_Missense_Mutation_p.S488F	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	513					lipid transport		lipid binding			ovary(1)	1						TGGATGATGGGACACCTATTA	0.279000													6	47					0	0	0.021553	0	0
GSX1	219409	broad.mit.edu	37	13	28367727	28367727	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr13:28367727G>A	uc001urr.1	+	2	485	c.437G>A	c.(436-438)AGC>AAC	p.S146N		NM_145657	NP_663632	Q9H4S2	GSX1_HUMAN	GS homeobox 1	146					positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CAGCTGCCCAGCAGCAAGAGG	0.597000													15	45					0	0	0.146539	0	0
DCLK1	9201	broad.mit.edu	37	13	36396959	36396959	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr13:36396959G>A	uc001uvf.2	-	11	1694	c.1461C>T	c.(1459-1461)GAC>GAT	p.D487D	DCLK1_uc001uve.3_Silent_p.D180D|DCLK1_uc010teh.1_Silent_p.D180D|DCLK1_uc010abk.2_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	487	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TCCCACTGGCGTCTCTCTCGG	0.507000													52	71					0	0	0.139131	0	0
PRTG	283659	broad.mit.edu	37	15	55930779	55930779	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr15:55930779C>T	uc002adg.2	-	14	2468	c.2420G>A	c.(2419-2421)AGC>AAC	p.S807N		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	807	Fibronectin type-III 4.				multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GACTACAGGGCTCCAAGGACT	0.353000													27	38					0	0	0.099896	0	0
PML	5371	broad.mit.edu	37	15	74315539	74315539	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr15:74315539C>T	uc002awv.2	+	3	1113	c.973C>T	c.(973-975)CGC>TGC	p.R325C	PML_uc002awm.2_Missense_Mutation_p.R325C|PML_uc002awl.2_Missense_Mutation_p.R325C|PML_uc002awj.1_Missense_Mutation_p.R325C|PML_uc002awk.2_Missense_Mutation_p.R325C|PML_uc002awn.2_Missense_Mutation_p.R325C|PML_uc002awo.2_Missense_Mutation_p.R325C|PML_uc002awp.2_Missense_Mutation_p.R325C|PML_uc002awq.2_Missense_Mutation_p.R325C|PML_uc002awr.2_Missense_Mutation_p.R325C|PML_uc002aws.2_Missense_Mutation_p.R325C|PML_uc002awt.2_Missense_Mutation_p.R325C|PML_uc002awu.2_Missense_Mutation_p.R325C|PML_uc010ule.1_Intron|PML_uc002aww.1_Missense_Mutation_p.R240C|PML_uc002awx.2_Missense_Mutation_p.R83C|PML_uc002awy.2_5'Flank	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	325					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						TGTGCTGCAGCGCATCCGCAC	0.692000			T	RARA|PAX5	APL|ALL								7	16					0	0	0.029380	0	0
C15orf42	90381	broad.mit.edu	37	15	90162963	90162963	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr15:90162963G>A	uc002boe.2	+	18	3044	c.3044G>A	c.(3043-3045)CGA>CAA	p.R1015Q		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	1015					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			CGAAGTCCTCGAATCAAGCAG	0.433000													18	136					0	0	0.043863	0	0
CACNG3	10368	broad.mit.edu	37	16	24358139	24358139	+	Splice_Site	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr16:24358139G>A	uc002dmf.2	+	2	1495	c.295_splice	c.e2+1	p.R99_splice		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3						regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		TATCTCCTGCGTAAGTTCCCC	0.552000													21	29					0	0	0.062417	0	0
SRCAP	10847	broad.mit.edu	37	16	30748554	30748554	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr16:30748554G>A	uc002dze.1	+	34	7578	c.7193G>A	c.(7192-7194)CGT>CAT	p.R2398H	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.R2193H	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	2398					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GTCAGTGAGCGTCTTCGTGGA	0.632000													20	26					0	0	0.062417	0	0
TEKT1	83659	broad.mit.edu	37	17	6716198	6716198	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr17:6716198C>T	uc002gdt.2	-	6	914	c.804G>A	c.(802-804)CTG>CTA	p.L268L	TEKT1_uc010vth.1_Silent_p.L122L	NM_053285	NP_444515	Q969V4	TEKT1_HUMAN	tektin 1	268	Potential.				microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|skin(1)	2		Myeloproliferative disorder(207;0.0255)				TTGTATCCTTCAGCCCATTCT	0.542000													9	79					0	0	0.069234	0	0
ABCA8	10351	broad.mit.edu	37	17	66887638	66887638	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr17:66887638C>A	uc002jhp.2	-	22	3195	c.3016G>T	c.(3016-3018)GAT>TAT	p.D1006Y	ABCA8_uc002jhq.2_Missense_Mutation_p.D1046Y|ABCA8_uc010wqq.1_Missense_Mutation_p.D1046Y|ABCA8_uc010wqr.1_Missense_Mutation_p.D985Y	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	1006						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ACCTTATAATCATCGATGCTG	0.353000													9	42					7.48243e-07	7.6942e-07	0.058154	1	0
VAPA	9218	broad.mit.edu	37	18	9950484	9950484	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr18:9950484C>T	uc002kok.2	+	5	809	c.510C>T	c.(508-510)ACC>ACT	p.T170T	VAPA_uc002koj.2_Silent_p.T215T	NM_194434	NP_919415	Q9P0L0	VAPA_HUMAN	vesicle-associated membrane protein-associated	170	Cytoplasmic (Potential).|Potential.				cell death|cellular membrane fusion|neuron projection development|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein localization in endoplasmic reticulum|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane|vesicle	protein heterodimerization activity|signal transducer activity|structural molecule activity				0						TTAATGATACCGAAACAAGGA	0.398000													3	86					0	0	0.115264	0	0
GRIN3B	116444	broad.mit.edu	37	19	1004821	1004821	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:1004821G>A	uc002lqo.1	+	3	1321	c.1321G>A	c.(1321-1323)GCG>ACG	p.A441T		NM_138690	NP_619635	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic,	441	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity				0		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GCAGTGCCCAGCGGGGCAGCT	0.672000													4	89					0	0	0.150653	0	0
TMIGD2	126259	broad.mit.edu	37	19	4298016	4298016	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:4298016C>T	uc002lzx.1	-	2	419	c.373G>A	c.(373-375)GAG>AAG	p.E125K	TMIGD2_uc010dtv.1_Missense_Mutation_p.E125K	NM_144615	NP_653216	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain	125	Extracellular (Potential).|Ig-like.					integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGTTGCCCTCAGCCTCCTCC	0.602000													5	200					0	0	0.021553	0	0
PLIN4	729359	broad.mit.edu	37	19	4511413	4511413	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:4511413C>T	uc002mar.1	-	3	2517	c.2517G>A	c.(2515-2517)ACG>ACA	p.T839T	PLIN4_uc010dub.1_Intron	NM_001080400	NP_001073869	Q96Q06	PLIN4_HUMAN	plasma membrane associated protein, S3-12	839	27 X 33 AA approximate tandem repeat.|23.			GLKTTQNIA -> SVDTTKTVL (in Ref. 2; BAB67774).		lipid particle|plasma membrane					0						TATTTTGGGTCGTTTTCAGCC	0.607000													45	73					0	0	0.124865	0	0
MUC16	94025	broad.mit.edu	37	19	9076980	9076980	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:9076980G>A	uc002mkp.2	-	3	10670	c.10466C>T	c.(10465-10467)ACA>ATA	p.T3489I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3490	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGAAGGAGATGTGACAGATGA	0.502000													18	47					0	0	0.076483	0	0
NLRP8	126205	broad.mit.edu	37	19	56466968	56466968	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:56466968C>T	uc002qmh.2	+	3	1615	c.1544C>T	c.(1543-1545)GCG>GTG	p.A515V	NLRP8_uc010etg.2_Missense_Mutation_p.A515V	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	515	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAATTTTTTGCGGCCTTGTTT	0.468000													5	287					0	0	0.021553	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701805	56701805	+	Silent	SNP	C	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:56701805C>G	uc010ygh.1	-	4	879	c.879G>C	c.(877-879)CTG>CTC	p.L293L		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	293					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGGGACTGCTCAGATTCAGAG	0.527000													81	124					0	0	0.139131	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56703294	56703294	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:56703294C>G	uc010ygh.1	-	2	513	c.513G>C	c.(511-513)CAG>CAC	p.Q171H		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	171					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CCGGATGCATCTGGTTCACAG	0.612000													6	12					0	0	0.029380	0	0
APOB	338	broad.mit.edu	37	2	21251367	21251367	+	Missense_Mutation	SNP	G	A	A	rs12714214	byFrequency	TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:21251367G>A	uc002red.2	-	13	1789	c.1661C>T	c.(1660-1662)CCG>CTG	p.P554L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	554	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTATCTCCCGGAGAAGCATC	0.453000													7	124					0	0	0.047766	0	0
C2orf78	388960	broad.mit.edu	37	2	74043169	74043169	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:74043169C>T	uc002sjr.1	+	3	1940	c.1819C>T	c.(1819-1821)CGG>TGG	p.R607W		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	607	Lys-rich.									ovary(2)	2						CAATATGAAACGGAAGAAAAA	0.443000													4	44					0	0	0.014758	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529638	80529638	+	Missense_Mutation	SNP	A	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:80529638A>G	uc002sok.1	-	2	1577	c.1307T>C	c.(1306-1308)ATC>ACC	p.I436T	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	436	Helical; (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GAAGGAGAAGATGAGGGCCAT	0.627000										HNSCC(69;0.2)			15	35					0	0	0.132662	0	0
TGOLN2	10618	broad.mit.edu	37	2	85554084	85554084	+	Silent	SNP	A	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:85554084A>C	uc010fgd.1	-	2	1060	c.771T>G	c.(769-771)CCT>CCG	p.P257P	TGOLN2_uc002soz.2_Silent_p.P257P|TGOLN2_uc002spa.2_Intron|TGOLN2_uc002spb.2_Intron|TGOLN2_uc002spc.1_Silent_p.P257P	NM_006464	NP_006455	O43493	TGON2_HUMAN	trans-golgi network protein 2	257	Extracellular (Potential).					integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding				0						CTTTCCGGGAAGGCTGCTCTG	0.572000													39	68					0	0	0.080422	0	0
CHST10	9486	broad.mit.edu	37	2	101010080	101010080	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:101010080C>T	uc002tam.2	-	7	1057	c.698G>A	c.(697-699)CGG>CAG	p.R233Q		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	233	Lumenal (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						CTGGATCCCCCGGGTCTCTGT	0.507000													6	198					0	0	0.021553	0	0
IL1A	3552	broad.mit.edu	37	2	113539283	113539283	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:113539283C>T	uc002tig.2	-	4	1177	c.217G>A	c.(217-219)GTA>ATA	p.V73I		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	73					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						GTTGCTACTACCACCATGCTC	0.483000													45	127					0	0	0.117977	0	0
MYO7B	4648	broad.mit.edu	37	2	128324316	128324316	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:128324316C>T	uc002top.2	+	5	437	c.384C>T	c.(382-384)GGC>GGT	p.G128G		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	128	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCCATATGGGCGAGCTGCCCC	0.587000													7	17					0	0	0.038147	0	0
FKBP7	51661	broad.mit.edu	37	2	179343117	179343117	+	Missense_Mutation	SNP	A	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:179343117A>G	uc002umk.2	-	1	239	c.110T>C	c.(109-111)ATA>ACA	p.I37T	FKBP7_uc002umm.2_Missense_Mutation_p.I37T|FKBP7_uc002uml.2_RNA|FKBP7_uc010zff.1_Missense_Mutation_p.I33T|PLEKHA3_uc002umn.2_5'Flank	NM_181342	NP_851939	Q9Y680	FKBP7_HUMAN	FK506 binding protein 7 isoform a precursor	37					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			CAAAACTTCTATTTTCACTTC	0.418000													56	101					0	0	0.139131	0	0
TTN	7273	broad.mit.edu	37	2	179483051	179483051	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:179483051C>T	uc010zfg.1	-	201	39654	c.39430G>A	c.(39430-39432)GAG>AAG	p.E13144K	TTN_uc010zfh.1_Missense_Mutation_p.E6839K|TTN_uc010zfi.1_Missense_Mutation_p.E6772K|TTN_uc010zfj.1_Missense_Mutation_p.E6647K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14071							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACAACTCTCTGCACGGTCT	0.463000													16	120					0	0	0.146539	0	0
MAP2	4133	broad.mit.edu	37	2	210557806	210557806	+	Nonsense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:210557806G>A	uc002vde.1	+	7	1160	c.912G>A	c.(910-912)TGG>TGA	p.W304*	MAP2_uc002vdc.1_Nonsense_Mutation_p.W304*|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Nonsense_Mutation_p.W300*	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	304					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	TCCCAAAATGGGAAGGGAAAC	0.438000													6	75					0	0	0.021553	0	0
KIF16B	55614	broad.mit.edu	37	20	16485186	16485186	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr20:16485186G>A	uc002wpg.1	-	10	1165	c.1007C>T	c.(1006-1008)TCA>TTA	p.S336L	KIF16B_uc010gch.1_Missense_Mutation_p.S336L|KIF16B_uc010gci.1_Missense_Mutation_p.S336L|KIF16B_uc010gcj.1_Missense_Mutation_p.S336L	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	336	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						ATCAGCAGGTGAAATGGCTGT	0.363000													21	223					0	0	0.049695	0	0
RRBP1	6238	broad.mit.edu	37	20	17596583	17596583	+	Silent	SNP	G	A	A	rs146359410	byFrequency	TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr20:17596583G>A	uc002wpv.1	-	23	2994	c.2640C>T	c.(2638-2640)GCC>GCT	p.A880A	RRBP1_uc010zrp.1_Silent_p.A53A|RRBP1_uc002wpt.1_Silent_p.A250A|RRBP1_uc002wpu.2_Silent_p.A654A|RRBP1_uc002wpw.1_Silent_p.A880A|RRBP1_uc010gcl.1_Silent_p.A654A	NM_001042576	NP_001036041	Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1313	Cytoplasmic (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						CCTCAAACTCGGCCGTGAGCT	0.637000													8	42					0	0	0.038147	0	0
NFS1	9054	broad.mit.edu	37	20	34263075	34263075	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr20:34263075G>A	uc002xdw.1	-	8	904	c.840C>T	c.(838-840)GCC>GCT	p.A280A	CPNE1_uc002xdn.1_5'Flank|CPNE1_uc002xdo.1_5'Flank|CPNE1_uc002xdp.1_5'Flank|NFS1_uc002xdt.1_Silent_p.A220A|NFS1_uc002xdu.1_Silent_p.A220A|NFS1_uc002xdv.1_Intron|NFS1_uc010zvk.1_Silent_p.A78A|NFS1_uc010zvl.1_Silent_p.A229A	NM_021100	NP_066923	Q9Y697	NFS1_HUMAN	NFS1 nitrogen fixation 1 precursor	280					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)|skin(1)	2	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CACTCTGCAGGGCCTCCACAC	0.582000													12	23					0	0	0.132662	0	0
CBS	875	broad.mit.edu	37	21	44488638	44488638	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr21:44488638G>A	uc002zcu.2	-	4	542	c.297C>T	c.(295-297)TTC>TTT	p.F99F	CBS_uc002zcs.1_5'Flank|CBS_uc002zct.2_Silent_p.F99F|CBS_uc002zcw.3_Silent_p.F99F|CBS_uc002zcv.2_Silent_p.F99F	NM_000071	NP_000062	P35520	CBS_HUMAN	cystathionine-beta-synthase	99					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding				0					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	ACTTCAGGCCGAACTTCTTCC	0.443000													42	70					0	0	0.117977	0	0
RNF215	200312	broad.mit.edu	37	22	30776081	30776081	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr22:30776081C>T	uc003ahp.2	-	7	978	c.978G>A	c.(976-978)GCG>GCA	p.A326A	RNF215_uc011akw.1_Silent_p.A231A	NM_001017981	NP_001017981	Q9Y6U7	RN215_HUMAN	ring finger protein 215	326	Cytoplasmic (Potential).|RING-type; atypical.					integral to membrane	zinc ion binding			central_nervous_system(1)	1						CCAGGCACACCGCACAGGTCT	0.647000													41	65					0	0	0.117977	0	0
SULT4A1	25830	broad.mit.edu	37	22	44234843	44234843	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr22:44234843G>A	uc003bee.1	-	4	528	c.412C>T	c.(412-414)CTG>TTG	p.L138L	SULT4A1_uc003bed.1_Silent_p.L59L|SULT4A1_uc003bef.1_RNA|SULT4A1_uc011aqb.1_Intron	NM_014351	NP_055166	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	138					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GACACCACCAGATCCTTGGGG	0.557000													16	39					0	0	0.160694	0	0
ZCWPW2	152098	broad.mit.edu	37	3	28476663	28476663	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:28476663G>A	uc003ceh.2	+	4	563	c.395G>A	c.(394-396)GGA>GAA	p.G132E	ZCWPW2_uc003cei.2_Missense_Mutation_p.G132E|ZCWPW2_uc010hfo.2_5'UTR	NM_001040432	NP_001035522	Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	132	PWWP.						zinc ion binding			ovary(2)	2						GACCCGGATGGAAATGTTGAA	0.358000													34	62					0	0	0.183431	0	0
CTDSPL	10217	broad.mit.edu	37	3	38022265	38022265	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:38022265G>A	uc003chg.2	+	8	760	c.738G>A	c.(736-738)ACG>ACA	p.T246T	CTDSPL_uc003chh.2_Silent_p.T235T|CTDSPL_uc003chi.2_RNA	NM_001008392	NP_001008393	O15194	CTDSL_HUMAN	small CTD phosphatase 3 isoform 1	246	FCP1 homology.					nucleus	metal ion binding|phosphoprotein phosphatase activity				0		Melanoma(1037;0.0122)		KIRC - Kidney renal clear cell carcinoma(284;0.0729)|Kidney(284;0.0902)		ATGACATGACGGACACGGAGC	0.602000													24	30					0	0	0.099896	0	0
RNF123	63891	broad.mit.edu	37	3	49758728	49758728	+	Nonsense_Mutation	SNP	C	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:49758728C>A	uc003cxh.2	+	39	4021	c.3935C>A	c.(3934-3936)TCA>TAA	p.S1312*	RNF123_uc003cxi.2_RNA|AMIGO3_uc003cxj.2_5'Flank	NM_022064	NP_071347	Q5XPI4	RN123_HUMAN	ring finger protein 123	1312						cytoplasm	ligase activity|protein binding|zinc ion binding			kidney(3)|ovary(1)|lung(1)|breast(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		ACTACCTCCTCAGCTGCCTAG	0.547000													26	186					9.39395e-14	9.84558e-14	0.116897	1	0
CADPS	8618	broad.mit.edu	37	3	62556598	62556598	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:62556598G>A	uc003dll.2	-	9	1953	c.1593C>T	c.(1591-1593)ATC>ATT	p.I531I	CADPS_uc003dlk.1_Silent_p.I35I|CADPS_uc003dlm.2_Silent_p.I531I|CADPS_uc003dln.2_Silent_p.I531I	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	531	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CATTCTTACCGATGGCCCATA	0.393000													24	158					0	0	0.125774	0	0
OR5K3	403277	broad.mit.edu	37	3	98109725	98109725	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:98109725C>T	uc011bgw.1	+	1	216	c.216C>T	c.(214-216)TGC>TGT	p.C72C		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGATTCCTGCTGTTCCTCTG	0.393000													20	373					0	0	0.062417	0	0
GPR128	84873	broad.mit.edu	37	3	100373824	100373824	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:100373824G>C	uc003duc.2	+	12	1793	c.1525G>C	c.(1525-1527)GAC>CAC	p.D509H	GPR128_uc011bhc.1_Missense_Mutation_p.D210H|GPR128_uc003dud.2_Missense_Mutation_p.D32H	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	509	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TATTGACTTTGACAATAATGA	0.388000													8	200					0	0	0.047766	0	0
CCDC80	151887	broad.mit.edu	37	3	112357354	112357354	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:112357354G>A	uc003dzf.2	-	2	1617	c.1399C>T	c.(1399-1401)CGC>TGC	p.R467C	CCDC80_uc011bhv.1_Missense_Mutation_p.R467C|CCDC80_uc003dzg.2_Missense_Mutation_p.R467C|CCDC80_uc003dzh.1_Missense_Mutation_p.R467C	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	467										ovary(2)	2						CTGTCCATGCGGTTGTCCCGG	0.602000													11	130					0	0	0.119110	0	0
KIAA2018	205717	broad.mit.edu	37	3	113379802	113379802	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:113379802C>T	uc003eam.2	-	7	1138	c.727G>A	c.(727-729)GAA>AAA	p.E243K	KIAA2018_uc003eal.2_Missense_Mutation_p.E187K	NM_001009899	NP_001009899	Q68DE3	K2018_HUMAN	hypothetical protein LOC205717	243					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			skin(2)|ovary(1)	3						GATTCGCTTTCAGAGGTGGGA	0.478000													15	54					0	0	0.119110	0	0
STXBP5L	9515	broad.mit.edu	37	3	120876455	120876455	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:120876455C>G	uc003eec.3	+	9	998	c.858C>G	c.(856-858)TTC>TTG	p.F286L	STXBP5L_uc011bji.1_Missense_Mutation_p.F286L	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	286					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GTCGCCCTTTCCAGACCACAA	0.413000													11	168					0	0	0.093190	0	0
ATP2C1	27032	broad.mit.edu	37	3	130720086	130720086	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:130720086C>T	uc003enl.2	+	28	2874	c.2652C>T	c.(2650-2652)CTC>CTT	p.L884L	ATP2C1_uc011blg.1_Silent_p.L918L|ATP2C1_uc011blh.1_Silent_p.L879L|ATP2C1_uc011bli.1_Silent_p.L918L|ATP2C1_uc003enk.2_Silent_p.L868L|ATP2C1_uc003enm.2_Intron|ATP2C1_uc003enn.2_Silent_p.L868L|ATP2C1_uc003eno.2_Silent_p.L884L|ATP2C1_uc003enp.2_Intron|ATP2C1_uc003enq.2_Silent_p.L884L|ATP2C1_uc003enr.2_Intron|ATP2C1_uc003ens.2_Silent_p.L884L|ATP2C1_uc003ent.2_Silent_p.L884L|ATP2C1_uc003enu.2_Silent_p.L562L	NM_014382	NP_055197	P98194	AT2C1_HUMAN	calcium-transporting ATPase 2C1 isoform 1a	884	Helical; Name=10; (By similarity).				actin cytoskeleton reorganization|ATP biosynthetic process|calcium-dependent cell-cell adhesion|cellular calcium ion homeostasis|cellular manganese ion homeostasis|epidermis development|Golgi calcium ion homeostasis|Golgi calcium ion transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi apparatus|Golgi membrane|integral to membrane|trans-Golgi network	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|manganese ion binding|manganese-transporting ATPase activity|metal ion binding|signal transducer activity			skin(1)	1					Arsenic trioxide(DB01169)|Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Miconazole(DB01110)|Sevoflurane(DB01236)	TTTTGGGTCTCACCTCATCAG	0.343000									Hailey-Hailey_disease				11	145					0	0	0.080935	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	A	A	rs104886003		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353000	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			5	131					0	0	0.021553	0	0
FXR1	8087	broad.mit.edu	37	3	180666162	180666162	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr3:180666162G>C	uc003fkq.2	+	5	320	c.298G>C	c.(298-300)GAC>CAC	p.D100H	FXR1_uc003fkp.2_Missense_Mutation_p.D15H|FXR1_uc003fkr.2_Missense_Mutation_p.D100H|FXR1_uc011bqj.1_Missense_Mutation_p.D14H|FXR1_uc003fks.2_Missense_Mutation_p.D14H|FXR1_uc011bqk.1_Missense_Mutation_p.D51H|FXR1_uc011bql.1_Missense_Mutation_p.D87H	NM_005087	NP_005078	P51114	FXR1_HUMAN	fragile X mental retardation-related protein 1	100					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(1)	1	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TGCTGCTTGTGACGCTACTTA	0.299000													18	94					0	0	0.049695	0	0
LRRC66	339977	broad.mit.edu	37	4	52883762	52883762	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr4:52883762G>A	uc003gzi.2	-	1	31	c.18C>T	c.(16-18)TTC>TTT	p.F6F		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	6	Helical; (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TAATGACTCTGAAATAGAGGT	0.274000													5	47					0	0	0.014758	0	0
PTPN13	5783	broad.mit.edu	37	4	87671800	87671800	+	Missense_Mutation	SNP	A	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr4:87671800A>C	uc003hpz.2	+	18	3308	c.2828A>C	c.(2827-2829)TAC>TCC	p.Y943S	PTPN13_uc003hpy.2_Missense_Mutation_p.Y943S|PTPN13_uc003hqa.2_Missense_Mutation_p.Y943S|PTPN13_uc003hqb.2_Intron	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	943						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		CTGTCGCTTTACCAGCCATTG	0.468000													12	32					0	0	0.163468	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95155109	95155109	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr4:95155109G>A	uc003htc.3	+	4	628	c.373G>A	c.(373-375)GAG>AAG	p.E125K	SMARCAD1_uc003htb.3_Missense_Mutation_p.E125K|SMARCAD1_uc003htd.3_Missense_Mutation_p.E125K|SMARCAD1_uc010ila.2_5'UTR	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	125					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTTTAGTTCTGAGCCATCTGA	0.303000													8	66					0	0	0.047766	0	0
NAA15	80155	broad.mit.edu	37	4	140281653	140281653	+	Splice_Site	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr4:140281653G>A	uc003ihu.1	+	13	1667	c.1411_splice	c.e13-1	p.E471_splice		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						TTTCTGTATAGGAAGGAACAT	0.338000													9	104					0	0	0.058154	0	0
DNAH5	1767	broad.mit.edu	37	5	13786454	13786454	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr5:13786454G>A	uc003jfd.2	-	52	8696	c.8654C>T	c.(8653-8655)ACA>ATA	p.T2885I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2885					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CTCTTCAGATGTTTCACCTTT	0.353000									Kartagener_syndrome				10	78					0	0	0.080935	0	0
GHR	2690	broad.mit.edu	37	5	42718863	42718863	+	Silent	SNP	A	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr5:42718863A>G	uc003jmt.2	+	10	1297	c.1254A>G	c.(1252-1254)AAA>AAG	p.K418K	GHR_uc011cpq.1_Silent_p.K231K	NM_000163	NP_000154	P10912	GHR_HUMAN	growth hormone receptor precursor	418	Cytoplasmic (Potential).				2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			lung(4)|kidney(1)|skin(1)	6		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AGAGGTTAAAAGGGGAAGCAG	0.468000													3	121					0	0	0.115264	0	0
ODZ2	57451	broad.mit.edu	37	5	167645602	167645602	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr5:167645602C>T	uc010jjd.2	+	23	4679	c.4679C>T	c.(4678-4680)GCG>GTG	p.A1560V	ODZ2_uc003lzr.3_Missense_Mutation_p.A1330V|ODZ2_uc003lzt.3_Missense_Mutation_p.A933V|ODZ2_uc010jje.2_Missense_Mutation_p.A824V	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CGGATCAGGGCGGTCAGCAAG	0.493000													33	211					0	0	0.163468	0	0
HMP19	51617	broad.mit.edu	37	5	173491307	173491307	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr5:173491307G>A	uc003mcx.2	+	3	347	c.202G>A	c.(202-204)GCT>ACT	p.A68T		NM_015980	NP_057064	Q9Y328	NSG2_HUMAN	HMP19 protein	68	Cytoplasmic (Potential).				dopamine receptor signaling pathway	cytoplasmic vesicle membrane|Golgi cisterna membrane|integral to membrane|multivesicular body membrane	dopamine receptor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00925)|all_lung(126;0.0148)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCCGAAAATCGCTGAATTTAC	0.478000													13	37					0	0	0.093190	0	0
DLL1	28514	broad.mit.edu	37	6	170594675	170594675	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr6:170594675C>G	uc003qxm.2	-	6	1314	c.844G>C	c.(844-846)GGC>CGC	p.G282R		NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	282	Extracellular (Potential).|EGF-like 2.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		CAGAAAAGGCCCCCCCAGCCT	0.602000													17	24					0	0	0.160694	0	0
DGKB	1607	broad.mit.edu	37	7	14758207	14758207	+	Silent	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr7:14758207C>T	uc003ssz.2	-	5	613	c.426G>A	c.(424-426)CTG>CTA	p.L142L	DGKB_uc011jxt.1_Silent_p.L135L|DGKB_uc003sta.2_Silent_p.L142L|DGKB_uc011jxu.1_Silent_p.L142L|DGKB_uc011jxv.1_Silent_p.L142L	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	142					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CAAGCAGAGACAGGTAACAGA	0.448000													7	35					0	0	0.029380	0	0
MUC17	140453	broad.mit.edu	37	7	100675495	100675495	+	Silent	SNP	A	G	G			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr7:100675495A>G	uc003uxp.1	+	3	851	c.798A>G	c.(796-798)TCA>TCG	p.S266S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	266	Extracellular (Potential).|59 X approximate tandem repeats.|2.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAGCCTGTCAAACTCAGCTC	0.498000													75	107					0	0	0.139131	0	0
TRPV6	55503	broad.mit.edu	37	7	142569581	142569581	+	Missense_Mutation	SNP	C	T	T	rs150837047		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr7:142569581C>T	uc003wbx.1	-	15	2273	c.2057G>A	c.(2056-2058)CGA>CAA	p.R686Q	TRPV6_uc003wbw.1_Missense_Mutation_p.R472Q|TRPV6_uc010lou.1_Missense_Mutation_p.R557Q	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	686	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GGAGGTACTTCGAGACACTGA	0.587000													13	46					0	0	0.105934	0	0
MLL3	58508	broad.mit.edu	37	7	151962241	151962241	+	Nonsense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr7:151962241G>A	uc003wla.2	-	8	1285	c.1066C>T	c.(1066-1068)CAG>TAG	p.Q356*		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	356	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CAAAAGAACTGATCTAAGAGG	0.413000			N		medulloblastoma								13	281					0	0	0.119110	0	0
TTPA	7274	broad.mit.edu	37	8	63976819	63976819	+	Silent	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr8:63976819G>A	uc003xux.1	-	4	641	c.609C>T	c.(607-609)TTC>TTT	p.F203F		NM_000370	NP_000361	P49638	TTPA_HUMAN	tocopherol (alpha) transfer protein	203	CRAL-TRIO.				lipid metabolic process		transporter activity|vitamin E binding				0	Breast(64;0.0716)	all_cancers(86;0.145)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.123)			Vitamin E(DB00163)	AGACAGCATGGAAAATTACTG	0.308000													19	39					0	0	0.049695	0	0
TG	7038	broad.mit.edu	37	8	134108511	134108511	+	Missense_Mutation	SNP	G	A	A	rs143135039	byFrequency	TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr8:134108511G>A	uc003ytw.2	+	43	7507	c.7466G>A	c.(7465-7467)CGT>CAT	p.R2489H	TG_uc010mdw.2_Missense_Mutation_p.R1248H|TG_uc011ljb.1_Missense_Mutation_p.R858H|TG_uc011ljc.1_Missense_Mutation_p.R622H|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2489					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACTTCCTCCGTGAGCCTCCA	0.537000													78	224					0	0	0.139131	0	0
RUSC2	9853	broad.mit.edu	37	9	35560823	35560823	+	Nonsense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr9:35560823C>T	uc003zww.2	+	10	4441	c.4186C>T	c.(4186-4188)CAG>TAG	p.Q1396*	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Nonsense_Mutation_p.Q1396*	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1396						cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			CCGAAAAGCCCAGCGGGAGGC	0.642000													11	11					0	0	0.069234	0	0
KIAA1958	158405	broad.mit.edu	37	9	115336810	115336810	+	Missense_Mutation	SNP	G	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr9:115336810G>T	uc004bgf.1	+	2	625	c.450G>T	c.(448-450)GAG>GAT	p.E150D	KIAA1958_uc011lwx.1_Missense_Mutation_p.E150D	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	150										skin(1)	1						TGGTTTGTGAGTCTTCTGTTA	0.458000													59	92					5.12918e-33	5.42796e-33	0.139131	1	0
ZNF645	158506	broad.mit.edu	37	X	22291584	22291584	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chrX:22291584C>T	uc004dai.1	+	1	525	c.476C>T	c.(475-477)CCG>CTG	p.P159L		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	159						intracellular	zinc ion binding			lung(1)|pancreas(1)	2						CATATTGCTCCGCCACAAACT	0.463000													6	148					0	0	0.021553	0	0
ATP1B4	23439	broad.mit.edu	37	X	119509335	119509335	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chrX:119509335G>A	uc004esr.2	+	5	755	c.671G>A	c.(670-672)CGC>CAC	p.R224H	ATP1B4_uc004esq.2_Missense_Mutation_p.R220H|ATP1B4_uc011mtx.1_Missense_Mutation_p.R189H|ATP1B4_uc011mty.1_Missense_Mutation_p.R181H	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	224	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						CAATTTAAGCGCTCCTTCCTA	0.483000													37	130					0	0	0.074837	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186109	127186109	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chrX:127186109G>C	uc004eum.2	-	1	274	c.77C>G	c.(76-78)TCT>TGT	p.S26C		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	26						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						AATCTCTCCAGACAGGCCTGC	0.443000													6	110					0	0	0.029380	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186237	127186237	+	Translation_Start_Site	SNP	G	A	A	rs139494763	by1000genomes	TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chrX:127186237G>A	uc004eum.2	-	1	146	c.-51C>T	c.(-53--49)GACGT>GATGT			NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1							cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						GAACACTTACGTCACTCTCTG	0.393000													10	71					0	0	0.069234	0	0
ZIC3	7547	broad.mit.edu	37	X	136649872	136649872	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chrX:136649872G>A	uc004fak.2	+	1	1527	c.1022G>A	c.(1021-1023)CGT>CAT	p.R341H		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	341	C2H2-type 3.|Nuclear localization signal.			R->A: Increases its cytoplasmic localization. Does not interact with KPNA1 and KPNA6 and increases strongly its cytoplasmic localization; when associated with A-320; A-337; A-346; A- 349 and A-350.	cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					ATCTTTGCCCGTTCTGAGAAC	0.582000													35	106					0	0	0.064281	0	0
ARHGAP4	393	broad.mit.edu	37	X	153184293	153184293	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chrX:153184293C>T	uc004fjk.1	-	7	1067	c.1025G>A	c.(1024-1026)GGG>GAG	p.G342E	ARHGAP4_uc011mzf.1_Missense_Mutation_p.G319E|ARHGAP4_uc004fjl.1_Missense_Mutation_p.G382E|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	342					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACCTCATCCCCATCATGGGG	0.597000													7	120					0	0	0.047766	0	0
LEPRE1	64175	broad.mit.edu	37	1	43223463	43223464	+	Frame_Shift_Ins	INS	-	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:43223463_43223464insC	uc001chv.2	-	5	1183_1184	c.1070_1071insG	c.(1069-1071)GGCfs	p.G357fs	LEPRE1_uc001chw.2_Frame_Shift_Ins_p.G357fs|LEPRE1_uc001chx.3_Frame_Shift_Ins_p.G357fs	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	357					negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCTCACGGGGGCCGATGGATCT	0.535											OREG0013423	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	69	121	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	121484665	121484668	+	IGR	DEL	TGTT	-	-	rs71221555		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:121484665_121484668delTGTT								LOC647121 (170979 upstream) : None (None downstream)																							ggaaacactctgtttgtaaagtct	0.000													10	1569	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	121484805	121484805	+	IGR	DEL	C	-	-	rs1842867		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:121484805delC								LOC647121 (171119 upstream) : None (None downstream)																							gttgaacgttcccttagacag	0.000													7	1566	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	121485005	121485008	+	IGR	DEL	TGTT	-	-	rs28831473		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr1:121485005_121485008delTGTT								LOC647121 (171319 upstream) : None (None downstream)																							ggaaacgctctgtttgtaaagtct	0.000													10	1409	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	42400455	42400456	+	IGR	INS	-	G	G	rs71264011		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:42400455_42400456insG								None (None upstream) : LOC441666 (426859 downstream)																							cttctttgtgttgtgtgtattc	0.000													8	552	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	122114155	122114155	+	IGR	DEL	C	-	-			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr10:122114155delC								SEC23IP (412910 upstream) : PPAPDC1A (102311 downstream)																							AAAGTTCATTCTTTTTTTTTT	0.308													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	19	14991072	14991072	+	IGR	DEL	A	-	-	rs34163436		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr19:14991072delA								OR7A10 (38383 upstream) : OR7A17 (168 downstream)																							AAAGCTTTATAAAGGAATACA	0.313													5	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	58479808	58479808	+	IGR	DEL	A	-	-			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr2:58479808delA								FANCL (11293 upstream) : None (None downstream)																							TTTGtaaattaaaaaaaaaaa	0.234													3	6	---	---	---	---					
Unknown	0	broad.mit.edu	37	20	32823673	32823680	+	IGR	DEL	AAGGAAGG	-	-	rs71337945		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr20:32823673_32823680delAAGGAAGG								EIF2S2 (123588 upstream) : ASIP (24491 downstream)																							gaaggaaggaaaggaaggaaggaaggaa	0.000													3	4	---	---	---	---					
SEMA6A	57556	broad.mit.edu	37	5	115783191	115783192	+	Frame_Shift_Ins	INS	-	T	T			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr5:115783191_115783192insT	uc010jck.2	-	19	2919_2920	c.2210_2211insA	c.(2209-2211)AACfs	p.N737fs	SEMA6A_uc003krx.3_Frame_Shift_Ins_p.N754fs|SEMA6A_uc011cwe.1_Frame_Shift_Ins_p.N116fs|SEMA6A_uc003krv.3_Frame_Shift_Ins_p.N164fs|SEMA6A_uc003krw.3_Frame_Shift_Ins_p.N214fs|SEMA6A_uc010jcj.2_Frame_Shift_Ins_p.N281fs	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	737	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TCTTGGCCGTGTTGCCGGGAGT	0.614													97	200	---	---	---	---					
Unknown	0	broad.mit.edu	37	7	1396145	1396146	+	IGR	DEL	TT	-	-	rs149226520		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr7:1396145_1396146delTT								UNCX (119533 upstream) : MICALL2 (77850 downstream)																							ccttccttcctttttttttttt	0.010													3	5	---	---	---	---					
RNF139	11236	broad.mit.edu	37	8	125487355	125487356	+	Frame_Shift_Ins	INS	-	G	G	rs143166634	by1000genomes	TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr8:125487355_125487356insG	uc003yrc.2	+	1	348_349	c.5_6insG	c.(4-6)GCGfs	p.A2fs	uc003yrb.2_5'Flank	NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	2					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CGGCTCATGGCGGCCGTGGGGC	0.554									Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				7	22	---	---	---	---					
GLDC	2731	broad.mit.edu	37	9	6645354	6645355	+	Frame_Shift_Ins	INS	-	C	C			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr9:6645354_6645355insC	uc003zkc.2	-	1	338_339	c.145_146insG	c.(145-147)GCCfs	p.A49fs		NM_000170	NP_000161	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	49					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			ovary(2)	2		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GAGGCGCGAGGCCCCAGCCGCG	0.649													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	9	68413605	68413606	+	RNA	DEL	CT	-	-			TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chr9:68413605_68413606delCT	uc004aex.2	+	1		c.160_161delCT								Homo sapiens mRNA; cDNA DKFZp564N0763 (from clone DKFZp564N0763).																		TTTGCTGAAACTCTGGGGTTGA	0.609													4	7	---	---	---	---					
SRPX	8406	broad.mit.edu	37	X	38079976	38079978	+	In_Frame_Del	DEL	GCA	-	-	rs72249350		TCGA-C5-A1M5-01A-11D-A13W-08	TCGA-C5-A1M5-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	90369746-5572-4f29-9852-1663cbc0179d	d260e788-4165-4610-a331-06e6cd6e0374	g.chrX:38079976_38079978delGCA	uc004ddy.1	-	1	154_156	c.68_70delTGC	c.(67-72)CTGCGC>CGC	p.L23del	SRPX_uc004ddz.1_In_Frame_Del_p.L23del|SRPX_uc011mkh.1_In_Frame_Del_p.L23del|SRPX_uc011mki.1_In_Frame_Del_p.L23del	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	23			Missing.		cell adhesion	cell surface|membrane					0						GGCGGGACGCgcagcagcagcag	0.576											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	8	---	---	---	---					
