Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MGC70870	403340	broad.mit.edu	37	GL000205.1	117491	117491	+	RNA	SNP	G	C	C			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chrGL000205.1:117491G>C	uc002kgk.4	+	0		c.869G>C								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GTGCAGGTGGGCAGTGGCTAC	0.582000														39			5		0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17745123	17745123	+	Nonsense_Mutation	SNP	C	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chrX:17745123C>A	uc011mix.2	+	6	3235	c.2897C>A	c.(2896-2898)tCa>tAa	p.S966*	NHS_uc004cxx.3_Nonsense_Mutation_p.S945*|NHS_uc004cxy.3_Nonsense_Mutation_p.S789*|NHS_uc004cxz.3_Nonsense_Mutation_p.S768*|NHS_uc004cya.3_Nonsense_Mutation_p.S668*	NM_001136024	NP_001129496	Q6T4R5	NHS_HUMAN	Homo sapiens Nance-Horan syndrome (congenital cataracts and dental anomalies) (NHS), transcript variant 2, mRNA.	945						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CTATCTAATTCAAGCACCGCT	0.438000														126			4		0.00909568	0.00909568	1	1	0
LSM14A	26065	broad.mit.edu	37	19	34710315	34710315	+	Silent	SNP	T	G	G			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr19:34710315T>G	uc002nvb.4	+	6	997	c.801T>G	c.(799-801)gcT>gcG	p.A267A	LSM14A_uc002nva.4_Silent_p.A267A|LSM14A_uc010xru.2_Silent_p.A226A|LSM14A_uc002nvc.4_Silent_p.A73A	NM_001114093	NP_001107565	Q8ND56	LS14A_HUMAN	Homo sapiens LSM14A, SCD6 homolog A (S. cerevisiae) (LSM14A), transcript variant 1, mRNA.	267					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule		p.A267A(4)		breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					CTCCTTCAGCTCCAAGGAGAG	0.438000														62			4		0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37657501	37657501	+	Splice_Site	SNP	A	G	G			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr17:37657501A>G	uc010cvv.3	+	6	3006	c.2420_splice	c.e6-2	p.G807_splice	CDK12_uc010wef.1_Splice_Site_p.G806_splice|CDK12_uc002hrw.4_Splice_Site_p.G807_splice	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Homo sapiens cyclin-dependent kinase 12 (CDK12), transcript variant 1, mRNA.	807	Protein kinase.				RNA splicing|mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity|protein binding			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						GTCTTTATGTAGGTGCCTTTT	0.353000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)				75			3		0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25543442	25543442	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr18:25543442G>A	uc002kwg.2	-	14	2852	c.2393C>T	c.(2392-2394)cCt>cTt	p.P798L	CDH2_uc010xbn.1_Missense_Mutation_p.P767L	NM_001792	NP_001783	P19022	CADH2_HUMAN	Homo sapiens cadherin 2, type 1, N-cadherin (neuronal) (CDH2), mRNA.	798					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GATGGCATCAGGCTCCACAGT	0.532000														96			5		0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101661717	101661717	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr8:101661717A>G	uc003yjr.3	-	0	177	c.26T>C	c.(25-27)gTg>gCg	p.V9A		NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	Homo sapiens sorting nexin 31 (SNX31), mRNA.	9	PX.				cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CTGCTGGGACACCGGGATACA	0.692000														32			3		0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176915167	176915167	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr1:176915167C>T	uc001glc.3	-	12	2356	c.2144G>A	c.(2143-2145)aGc>aAc	p.S715N	ASTN1_uc001glb.1_Missense_Mutation_p.S715N|ASTN1_uc001gld.1_Missense_Mutation_p.S715N|ASTN1_uc009wwx.1_Missense_Mutation_p.S715N	NM_004319	NP_004310	O14525	ASTN1_HUMAN	Homo sapiens astrotactin 1 (ASTN1), transcript variant 1, mRNA.	723					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						AAGCTCCCTGCTTTCCCCACA	0.537000														39			5		0	0	1	0	0
BC112340	0	broad.mit.edu	37	22	18835298	18835298	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr22:18835298T>C	uc002zoc.3	+	0	975	c.854T>C	c.(853-855)gTa>gCa	p.V285A	BC112340_uc010grj.1_5'Flank					SubName: Full=Uncharacterized protein;																		AGTATGGATGTACAGCAGGAG	0.557000														16			7		0	0	1	0	0
MAP1LC3A	84557	broad.mit.edu	37	20	33147658	33147658	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr20:33147658T>C	uc002xaq.1	+	3	476	c.322T>C	c.(322-324)Ttc>Ctc	p.F108L	MAP1LC3A_uc002xap.1_Missense_Mutation_p.F112L	NM_032514	NP_115903	Q9H492	MLP3A_HUMAN	Homo sapiens microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A), transcript variant 1, mRNA.	108					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|cytosol|endomembrane system|microtubule	phosphatidylethanolamine binding|protein binding			cervix(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(2)	5						CGAGGACGGCTTCCTCTATAT	0.647000														117			4		0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201868999	201868999	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr1:201868999A>G	uc021phl.1	-	1	1390	c.1142T>C	c.(1141-1143)aTc>aCc	p.I381T	LMOD1_uc021phm.1_Missense_Mutation_p.I381T|LMOD1_uc010ppu.2_Missense_Mutation_p.I330T	NM_012134	NP_036266	P29536	LMOD1_HUMAN	Homo sapiens leiomodin 1 (smooth muscle) (LMOD1), mRNA.	381					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CTTGAGCATGATGGCAATGGC	0.567000														111			4		0	0	1	0	0
RCVRN	5957	broad.mit.edu	37	17	9808240	9808240	+	Silent	SNP	G	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr17:9808240G>A	uc002gme.1	-	0	445	c.258C>T	c.(256-258)taC>taT	p.Y86Y		NM_002903	NP_002894	P35243	RECO_HUMAN	Homo sapiens recoverin (RCVRN), mRNA.	86	EF-hand 2.				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	12						GGGCGATGACGTACTCCTTGA	0.607000														96			12		0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149460495	149460495	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr5:149460495C>T	uc003lrl.3	-	1	337	c.142G>A	c.(142-144)Gtg>Atg	p.V48M	CSF1R_uc011dcd.2_5'UTR|CSF1R_uc010jhc.3_Non-coding_Transcript|CSF1R_uc003lrm.3_Missense_Mutation_p.V48M|CSF1R_uc011dce.1_Missense_Mutation_p.V48M|CSF1R_uc011dcf.2_Missense_Mutation_p.V48M	NM_005211	NP_005202	P07333	CSF1R_HUMAN	Homo sapiens colony stimulating factor 1 receptor (CSF1R), mRNA.	48	Ig-like C2-type 1.				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	TCCCATTCCACGCTGCCATTG	0.597000														148			29		0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47667069	47667069	+	Silent	SNP	G	A	A	rs61760489		TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr4:47667069G>A	uc003gxm.3	-	10	1662	c.1569C>T	c.(1567-1569)ggC>ggT	p.G523G	CORIN_uc011bzf.2_Silent_p.G384G|CORIN_uc011bzg.2_Silent_p.G456G|CORIN_uc011bzh.1_Silent_p.G486G|CORIN_uc011bzi.1_Silent_p.G486G	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	Homo sapiens corin, serine peptidase (CORIN), mRNA.	523	FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GGATATGCTCGCCTGTATTCA	0.423000														121			8		0	0	1	0	0
BEND6	221336	broad.mit.edu	37	6	56846621	56846621	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr6:56846621G>A	uc010kab.3	+	1	599	c.13G>A	c.(13-15)Gtg>Atg	p.V5M	BEND6_uc003pdg.2_Non-coding_Transcript	NM_152731	NP_689944	Q5SZJ8	BEND6_HUMAN	Homo sapiens BEN domain containing 6 (BEND6), mRNA.	5										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						GCAGAAGATCGTGCAGACAGA	0.368000														22			19		0	0	1	0	0
MRPL49	740	broad.mit.edu	37	11	64889873	64889873	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr11:64889873C>T	uc001oda.2	+	0	158	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	FAU_uc001ocx.3_5'Flank|MRPL49_uc021qle.1_Intron|MRPL49_uc021qlf.1_Missense_Mutation_p.A7V	NM_004927	NP_004918	Q13405	RM49_HUMAN	Homo sapiens mitochondrial ribosomal protein L49 (MRPL49), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	19					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			endometrium(1)|ovary(1)	2						CGGTGTCCAGCGGGGCTGCGG	0.612000														58			4		0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2788865	2788865	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr12:2788865G>A	uc009zdu.1	+	43	5804	c.5491G>A	c.(5491-5493)Ggc>Agc	p.G1831S	CACNA1C_uc001qkc.2_Missense_Mutation_p.G1802S|CACNA1C_uc001qjz.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qkd.2_Missense_Mutation_p.G1802S|CACNA1C_uc001qke.2_Missense_Mutation_p.G1772S|CACNA1C_uc001qkf.2_Missense_Mutation_p.G1791S|CACNA1C_uc009zdw.1_Missense_Mutation_p.G1824S|CACNA1C_uc001qkg.2_Missense_Mutation_p.G1789S|CACNA1C_uc001qkh.2_Missense_Mutation_p.G1791S|CACNA1C_uc001qkl.2_Missense_Mutation_p.G1831S|CACNA1C_uc001qkj.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qkk.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qkn.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qkm.2_Missense_Mutation_p.G1772S|CACNA1C_uc001qko.2_Missense_Mutation_p.G1803S|CACNA1C_uc001qkp.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qkq.2_Missense_Mutation_p.G1811S|CACNA1C_uc001qku.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qkr.2_Missense_Mutation_p.G1800S|CACNA1C_uc001qks.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qkt.2_Missense_Mutation_p.G1802S|CACNA1C_uc009zdv.1_Missense_Mutation_p.G1780S|CACNA1C_uc001qkb.2_Missense_Mutation_p.G1783S|CACNA1C_uc001qki.1_Missense_Mutation_p.G1519S|CACNA1C_uc010sea.1_Missense_Mutation_p.G474S|AK093746_uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.G101S	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	Homo sapiens calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C), transcript variant 1, mRNA.	1831					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCGCCCCGCCGGCTACCCCAG	0.677000														33			18		0	0	1	0	0
ACTL10	170487	broad.mit.edu	37	20	32255643	32255643	+	Missense_Mutation	SNP	G	C	C	rs144190881	byFrequency	TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr20:32255643G>C	uc002wzt.3	+	0	1340	c.340G>C	c.(340-342)Gtc>Ctc	p.V114L	NECAB3_uc002wzm.4_Intron|NECAB3_uc002wzn.4_Intron|NECAB3_uc002wzo.4_Intron	NM_001024675	NP_001019846	Q5JWF8	CT134_HUMAN	Homo sapiens actin-like 10 (ACTL10), mRNA.	114																	CGGGTGCTGCGTCTGCCTCAG	0.706000														54			13		0	0	1	0	0
COX4NB	10328	broad.mit.edu	37	16	85822626	85822626	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr16:85822626C>T	uc002fjd.3	-	1	509	c.262G>A	c.(262-264)Gtg>Atg	p.V88M	COX4NB_uc010vol.2_Missense_Mutation_p.V88M	NM_006067	NP_006058	O43402	CX4NB_HUMAN	Homo sapiens COX4 neighbor (COX4NB), transcript variant 1, mRNA.	88						mitochondrion|nucleus				large_intestine(1)|upper_aerodigestive_tract(1)	2						CCAGCAATCACGTAGCTATGA	0.438000														121			4		0	0	1	0	0
FAM189B	10712	broad.mit.edu	37	1	155221684	155221684	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr1:155221684G>A	uc001fjm.3	-	5	1240	c.634C>T	c.(634-636)Cgg>Tgg	p.R212W	FAM189B_uc009wql.3_5'UTR|FAM189B_uc001fjn.3_Missense_Mutation_p.R116W|FAM189B_uc001fjo.3_Missense_Mutation_p.R194W|FAM189B_uc001fjp.3_Intron	NM_006589	NP_006580	P81408	F189B_HUMAN	Homo sapiens family with sequence similarity 189, member B (FAM189B), transcript variant 1, mRNA.	212						integral to membrane	WW domain binding			breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23						GAGACTGACCGCTCAGGGGCC	0.617000														54			10		0	0	1	0	0
NT5DC1	221294	broad.mit.edu	37	6	116560197	116560197	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr6:116560197A>G	uc003pwj.3	+	10	1258	c.1163A>G	c.(1162-1164)aAt>aGt	p.N388S	NT5DC1_uc003pwl.3_Missense_Mutation_p.N338S	NM_152729	NP_689942	Q5TFE4	NT5D1_HUMAN	Homo sapiens 5'-nucleotidase domain containing 1 (NT5DC1), mRNA.	388							hydrolase activity|metal ion binding			large_intestine(2)|lung(2)|prostate(2)|skin(1)|stomach(1)	8		all_cancers(87;0.00367)|all_epithelial(87;0.00449)|Colorectal(196;0.0469)		all cancers(137;0.0327)|OV - Ovarian serous cystadenocarcinoma(136;0.0445)|GBM - Glioblastoma multiforme(226;0.0719)|Epithelial(106;0.112)		GGACTGGAAAATACAGAAGAC	0.363000														60			4		0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13906390	13906390	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr12:13906390C>T	uc001rbt.2	-	2	1050	c.871G>A	c.(871-873)Gcc>Acc	p.A291T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mRNA.	291					response to ethanol	N-methyl-D-aspartate selective glutamate receptor complex|cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|glycine binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTCACTCTGGCGGGGAGGCCA	0.537000														118			4		0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56578007	56578007	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr12:56578007T>C	uc001skb.3	-	5	620	c.514A>G	c.(514-516)Aac>Gac	p.N172D	SMARCC2_uc001skd.3_Missense_Mutation_p.N172D|SMARCC2_uc001ska.3_Missense_Mutation_p.N172D|SMARCC2_uc001skc.3_Missense_Mutation_p.N172D|SMARCC2_uc010sqf.2_Missense_Mutation_p.N61D	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), transcript variant 1, mRNA.	172					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex|nBAF complex|npBAF complex|nucleoplasm	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GAGGCATTGTTCTTATCCTCA	0.493000														105			4		0	0	1	0	0
HOOK1	51361	broad.mit.edu	37	1	60314061	60314061	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr1:60314061A>G	uc009wad.3	+	11	1106	c.1004A>G	c.(1003-1005)gAc>gGc	p.D335G	HOOK1_uc001czo.3_Missense_Mutation_p.D335G|HOOK1_uc001czp.3_Non-coding_Transcript|HOOK1_uc010oor.2_Missense_Mutation_p.D293G	NM_015888	NP_056972	Q9UJC3	HOOK1_HUMAN	Homo sapiens hook homolog 1 (Drosophila) (HOOK1), mRNA.	335	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					GATCTGAATGACCTTCGCAAG	0.363000														122			4		0	0	1	0	0
APOO	79135	broad.mit.edu	37	X	23874422	23874422	+	Silent	SNP	T	C	C			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chrX:23874422T>C	uc004dax.3	-	6	796	c.558A>G	c.(556-558)caA>caG	p.Q186Q	APOO_uc004day.4_Non-coding_Transcript	NM_024122	NP_077027	Q9BUR5	APOO_HUMAN	Homo sapiens apolipoprotein O (APOO), transcript variant 1, mRNA.	186					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|prostate(1)	9						TCCTCACCTTTTGAAAGTTCT	0.333000														51			10		0	0	1	0	0
EXOC8	149371	broad.mit.edu	37	1	231471905	231471905	+	Silent	SNP	G	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr1:231471905G>A	uc001huq.3	-	0	1674	c.1587C>T	c.(1585-1587)tgC>tgT	p.C529C		NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	Homo sapiens exocyst complex component 8 (EXOC8), mRNA.	529					exocytosis|protein transport	growth cone|nucleus	protein binding			cervix(2)|endometrium(1)|large_intestine(2)|liver(1)|lung(5)|prostate(1)|skin(1)|stomach(1)	14	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				CCAGTTGCTGGCAATGCTCCT	0.483000														43			41		0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70884529	70884529	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr16:70884529T>C	uc002ezr.3	-	73	12621	c.12470A>G	c.(12469-12471)aAg>aGg	p.K4157R	HYDIN_uc010cfy.3_Non-coding_Transcript	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	Homo sapiens HYDIN, axonemal central pair apparatus protein (HYDIN), transcript variant 1, mRNA.	4158										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TCCTTCCTGCTTTGGTGTGAA	0.408000														108			4		0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54784436	54784436	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chrX:54784436C>T	uc004dtj.2	-	7	2101	c.2071G>A	c.(2071-2073)Gga>Aga	p.G691R		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	Homo sapiens inter-alpha-trypsin inhibitor heavy chain family, member 6 (ITIH6), mRNA.	691					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										GGGCTCTCTCCCAATGGCTCC	0.498000														434			19		0	0	1	0	0
FXR1	8087	broad.mit.edu	37	3	180666228	180666228	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr3:180666228delA	uc003fkq.3	+	4	604	c.364delA	c.(364-366)aaafs	p.K122fs	FXR1_uc003fkp.3_Frame_Shift_Del_p.K37fs|FXR1_uc003fkr.3_Frame_Shift_Del_p.K122fs|FXR1_uc011bqj.2_Frame_Shift_Del_p.K36fs|FXR1_uc003fks.3_Frame_Shift_Del_p.K36fs|FXR1_uc011bqk.2_Frame_Shift_Del_p.K73fs|FXR1_uc011bql.2_Frame_Shift_Del_p.K109fs	NM_005087	NP_001013457	P51114	FXR1_HUMAN	Homo sapiens fragile X mental retardation, autosomal homolog 1 (FXR1), transcript variant 1, mRNA.	122					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome		p.N124fs*14(1)		breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TAAAACTGTCAAAAAAAATAC	0.333													---	84	---	---	9	---					
GNPNAT1	64841	broad.mit.edu	37	14	53247394	53247395	+	Splice_Site	INS	-	A	A			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr14:53247394_53247395insA	uc001xab.3	-	5	662	c.407_splice	c.e5+1	p.L136_splice		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	Homo sapiens glucosamine-phosphate N-acetyltransferase 1 (GNPNAT1), mRNA.	136	N-acetyltransferase.				UDP-N-acetylglucosamine biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|cytosol|endosome membrane	glucosamine 6-phosphate N-acetyltransferase activity			liver(1)|lung(1)|prostate(1)|skin(1)	4	Breast(41;0.176)					TCTGCCTACTTACAATTTGCCA	0.332													---	167	---	---	7	---					
SIPA1L3	23094	broad.mit.edu	37	19	38655328	38655329	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KL-8327-01A-11D-2310-10	TCGA-KL-8327-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d72a7338-c144-4c62-a70e-2177a3b4b77e	15d4fbce-ae77-4500-ab53-a29ab6c75019	g.chr19:38655328_38655329insC	uc002ohk.3	+	14	4499_4500	c.3990_3991insC	c.(3988-3993)cggcccfs	p.R1330fs		NM_015073	NP_055888	O60292	SI1L3_HUMAN	Homo sapiens signal-induced proliferation-associated 1 like 3 (SIPA1L3), mRNA.	1330					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity	p.P1331S(2)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			AGGCTCCACGGCCCGCCAAGCC	0.673													---	112	---	---	7	---					
