Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF831	128611	broad.mit.edu	37	20	57768140	57768140	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr20:57768140C>T	uc002yan.3	+	0	2066	c.2066C>T	c.(2065-2067)aCg>aTg	p.T689M		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	Homo sapiens zinc finger protein 831 (ZNF831), mRNA.	689						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCAGGGGCAACGCCAGAGCCT	0.617000														35			30		0	0	1	0	0
SOWAHA	134548	broad.mit.edu	37	5	132150835	132150835	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr5:132150835G>A	uc003kxw.3	+	0	1803	c.1522G>A	c.(1522-1524)Gcc>Acc	p.A508T		NM_175873	NP_787069	Q2M3V2	ANR43_HUMAN	Homo sapiens sosondowah ankyrin repeat domain family member A (SOWAHA), mRNA.	508																	GTTCTTGAGCGCCTCGCCCAT	0.582000														66			4		0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303811	151303811	+	Silent	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrX:151303811G>A	uc022cgz.1	-	0	282	c.282C>T	c.(280-282)ccC>ccT	p.P94P	MAGEA5_uc022cgy.1_Intron|MAGEA10_uc004ffk.3_Silent_p.P94P|MAGEA10_uc004ffm.2_Silent_p.P94P|MAGEA10_uc004ffl.3_Silent_p.P94P	NM_021048	NP_066386	P43363	MAGAA_HUMAN	Homo sapiens melanoma antigen family A, 10 (MAGEA10), transcript variant 2, mRNA.	94								p.P94T(1)		endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CAACGACCGAGGGGGAGGAGC	0.547000														57			43		0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102516466	102516466	+	Silent	SNP	C	G	G			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr15:102516466C>G	uc002cdi.3	+	10	2212	c.792C>G	c.(790-792)tcC>tcG	p.S264S	WASH3P_uc010bpo.3_Non-coding_Transcript|WASH3P_uc002cdq.3_Non-coding_Transcript|WASH3P_uc002cdr.3_Non-coding_Transcript					Homo sapiens WAS protein family homolog 3 pseudogene (WASH3P), non-coding RNA.									p.S463S(2)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						ACTGGGAATCCTAGGGGGCTC	0.642000														300			7		0	0	1	0	0
STRA8	346673	broad.mit.edu	37	7	134925328	134925328	+	Missense_Mutation	SNP	C	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr7:134925328C>A	uc011kpx.2	+	1	118	c.118C>A	c.(118-120)Ctg>Atg	p.L40M		NM_182489	NP_872295	Q7Z7C7	STRA8_HUMAN	Homo sapiens stimulated by retinoic acid gene 8 homolog (mouse) (STRA8), mRNA.	40					DNA replication|regulation of transcription, DNA-dependent	cytoplasm|nucleus		p.L40M(2)		breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|urinary_tract(1)	16						AACACCCCAGCTGCCAGCACA	0.537000														176			8		5.4927e-09	5.79785e-09	1	1	0
AKAP10	11216	broad.mit.edu	37	17	19823386	19823386	+	Silent	SNP	T	C	C	rs1049591		TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr17:19823386T>C	uc002gwo.3	-	11	1934	c.1797A>G	c.(1795-1797)cgA>cgG	p.R599R	AKAP10_uc002gwp.1_Silent_p.R599R|AKAP10_uc010cqw.1_Silent_p.R541R	NM_007202	NP_009133	O43572	AKA10_HUMAN	Homo sapiens A kinase (PRKA) anchor protein 10 (AKAP10), nuclear gene encoding mitochondrial protein, mRNA.	599					blood coagulation|protein localization	cytosol|mitochondrion|plasma membrane	signal transducer activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	21	all_cancers(12;2.08e-05)|all_epithelial(12;0.00158)|Breast(13;0.165)					GCTCAGATTCTCGGATGAATT	0.348000														5			42		0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99661925	99661925	+	Silent	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrX:99661925G>A	uc010nmz.3	-	0	3347	c.1671C>T	c.(1669-1671)aaC>aaT	p.N557N	PCDH19_uc004efw.4_Silent_p.N557N|PCDH19_uc004efx.4_Silent_p.N557N	NM_001184880	NP_001171809	Q8TAB3	PCD19_HUMAN	Homo sapiens protocadherin 19 (PCDH19), transcript variant 3, mRNA.	557	Cadherin 5.		N -> K (in EIEE9).		homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						GGGTGTTGTCGTTGACGTCGA	0.582000														84			33		0	0	1	0	0
AP5Z1	9907	broad.mit.edu	37	7	4830447	4830447	+	Silent	SNP	C	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr7:4830447C>A	uc003sne.3	+	15	2167	c.2082C>A	c.(2080-2082)ccC>ccA	p.P694P	AP5Z1_uc010ksp.3_Non-coding_Transcript|AP5Z1_uc003snf.3_Silent_p.P171P|MIR4656_uc021zzb.1_5'Flank	NM_014855	NP_055670	O43299	K0415_HUMAN	Homo sapiens KIAA0415 (KIAA0415), mRNA.	694					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding										CCAGGTGTCCCCCCCAGGTGG	0.642000														45			3		0.004672	0.004672	1	1	0
AICDA	57379	broad.mit.edu	37	12	8759502	8759502	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr12:8759502C>T	uc001qur.2	-	1	194	c.115G>A	c.(115-117)Gct>Act	p.A39T	AICDA_uc001qup.1_Missense_Mutation_p.A34T|AICDA_uc001quq.1_Missense_Mutation_p.A34T|AICDA_uc009zgd.1_Non-coding_Transcript	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	Homo sapiens activation-induced cytidine deaminase (AICDA), mRNA.	39					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(2)|pancreas(1)	16	Lung SC(5;0.184)					AAGGATGTAGCACTGTCACGC	0.453000														41			8		0	0	1	0	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	102260	102260	+	Silent	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrGL000209.1:102260G>A	uc021vdb.1	+	2	206	c.195G>A	c.(193-195)acG>acA	p.T65T	KIR2DL2_uc002qtt.2_Intron|KIR2DL2_uc002qty.3_Intron|KIR2DL2_uc010yie.2_Intron|KIR2DL2_uc002qul.2_Silent_p.T65T	NM_014513	NP_055328	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 (KIR2DS5), mRNA.	65	Ig-like C2-type 1.				regulation of immune response	integral to membrane|plasma membrane	receptor activity										GAGAGGGGACGTTTAACCACA	0.532000														79			5		0	0	1	0	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	102226	102226	+	Missense_Mutation	SNP	T	G	G			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrGL000209.1:102226T>G	uc021vdb.1	+	2	172	c.161T>G	c.(160-162)aTg>aGg	p.M54R	KIR2DL2_uc002qtt.2_Intron|KIR2DL2_uc002qty.3_Intron|KIR2DL2_uc010yie.2_Intron|KIR2DL2_uc002qul.2_Missense_Mutation_p.M54R	NM_014513	NP_055328	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 (KIR2DS5), mRNA.	54	Ig-like C2-type 1.				regulation of immune response	integral to membrane|plasma membrane	receptor activity										TCAGATGTCATGTTTGAGCAC	0.522000														78			5		0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124399735	124399735	+	Silent	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr10:124399735C>T	uc001lgk.1	+	51	6841	c.6735C>T	c.(6733-6735)gtC>gtT	p.V2245V	DMBT1_uc001lgl.1_Silent_p.V2235V|DMBT1_uc001lgm.1_Silent_p.V1617V|DMBT1_uc021qaf.1_Silent_p.V2245V|DMBT1_uc021qag.1_Silent_p.V2235V|DMBT1_uc021qah.1_Silent_p.V1617V|DMBT1_uc009xzz.1_Silent_p.V2244V|DMBT1_uc010qtx.1_Silent_p.V965V|DMBT1_uc009yab.1_Silent_p.V948V|DMBT1_uc009yac.1_Silent_p.V539V	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	Homo sapiens deleted in malignant brain tumors 1 (DMBT1), transcript variant 2, mRNA.	2245	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|calcium-dependent protein binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCATCCAGGTCGAGGAAGTCC	0.468000														84			122		0	0	1	0	0
C4B	721	broad.mit.edu	37	6	31963559	31963559	+	Missense_Mutation	SNP	A	G	G	rs147162052		TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr6:31963559A>G	uc011doy.2	+	24	3269	c.3218A>G	c.(3217-3219)gAc>gGc	p.D1073G	C4B_uc011doz.2_Missense_Mutation_p.D1073G	NM_001242823	NP_001229752	P0C0L5	CO4B_HUMAN	Homo sapiens complement C4-B-like (LOC100293534), mRNA.	1073			D -> G (in allotype C4B1 and allotype C4B3; dbSNP:rs2258218).		complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										TTGTCACGGGACAGCAGCACC	0.612000														28			4		0	0	1	0	0
POM121L7	728418	broad.mit.edu	37	22	21481299	21481299	+	Silent	SNP	T	G	G			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr22:21481299T>G	uc010gsw.2	-	0	748	c.627A>C	c.(625-627)cgA>cgC	p.R209R	POM121L7_uc021wmb.1_Silent_p.R209R					SubName: Full=Uncharacterized protein;																		AAGGCTCCCCTCGCCTGCGTG	0.597000														7			4		0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46266522	46266522	+	Missense_Mutation	SNP	C	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr20:46266522C>A	uc002xtk.3	+	12	2768	c.2507C>A	c.(2506-2508)tCt>tAt	p.S836Y	NCOA3_uc002xtl.3_Missense_Mutation_p.S836Y|NCOA3_uc002xtn.3_Missense_Mutation_p.S836Y|NCOA3_uc010ght.2_Missense_Mutation_p.S846Y|NCOA3_uc002xtm.3_Missense_Mutation_p.S836Y|NCOA3_uc010zyc.2_Missense_Mutation_p.S631Y	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	Homo sapiens nuclear receptor coactivator 3 (NCOA3), transcript variant 1, mRNA.	836					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GGAACTAATTCTCTGGGTAAG	0.358000														73			33		1.04352e-10	1.13296e-10	1	1	0
PSMC6	5706	broad.mit.edu	37	14	53175080	53175080	+	Missense_Mutation	SNP	C	G	G			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr14:53175080C>G	uc010tqx.2	+	1	181	c.181C>G	c.(181-183)Ctg>Gtg	p.L61V	PSMC6_uc010tqv.2_Missense_Mutation_p.L61V|PSMC6_uc010tqw.2_Intron	NM_002806	NP_002797	P62333	PRS10_HUMAN	Homo sapiens proteasome (prosome, macropain) 26S subunit, ATPase, 6 (PSMC6), mRNA.	47					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding, bridging			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	19	Breast(41;0.176)					TGAAAATGATCTGAAGGCCCT	0.353000														112			49		0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1092920	1092920	+	Missense_Mutation	SNP	C	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr11:1092920C>A	uc001lsx.1	+	30	4766	c.4739C>A	c.(4738-4740)aCc>aAc	p.T1580N		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	1585	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ggcacacagaccccaacatcg	0.632000														24			3		0.004672	0.004672	1	1	0
ZNF185	7739	broad.mit.edu	37	X	152091354	152091354	+	Splice_Site	SNP	G	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrX:152091354G>T	uc011myg.2	+	11	875	c.827_splice	c.e11+1	p.S276_splice	ZNF185_uc011myi.2_Splice_Site_p.R276_splice|ZNF185_uc011myj.2_Intron|ZNF185_uc011myh.2_Splice_Site_p.R276_splice|ZNF185_uc011myk.2_Splice_Site_p.S277_splice|ZNF185_uc010ntv.2_Splice_Site_p.S276_splice|ZNF185_uc004fgw.4_Intron|ZNF185_uc004fgu.3_Intron|ZNF185_uc004fgv.3_Intron	NM_001178106	NP_001171577	O15231	ZN185_HUMAN	Homo sapiens zinc finger protein 185 (LIM domain) (ZNF185), transcript variant 1, mRNA.	276						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					AGGAGCTCAGGTGGGTGCCGA	0.637000														55			36		5.43694e-19	6.26071e-19	1	1	0
TNRC6A	27327	broad.mit.edu	37	16	24817998	24817998	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr16:24817998T>C	uc002dmm.3	+	16	4547	c.4433T>C	c.(4432-4434)cTc>cCc	p.L1478P	TNRC6A_uc010bxs.3_Missense_Mutation_p.L1225P|TNRC6A_uc002dmn.3_Missense_Mutation_p.L1176P|TNRC6A_uc002dmo.3_Missense_Mutation_p.L1117P|TNRC6A_uc002dmp.3_Missense_Mutation_p.L79P|TNRC6A_uc002dmq.3_Missense_Mutation_p.L145P	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	Homo sapiens trinucleotide repeat containing 6A (TNRC6A), mRNA.	1478					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	RNA binding|nucleotide binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CAGCAGCCACTCCATCAGCCA	0.493000														122			5		0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32052298	32052298	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr6:32052298G>A	uc003nzl.2	-	7	3539	c.3337C>T	c.(3337-3339)Cgc>Tgc	p.R1113C		NM_019105	NP_061978	P22105	TENX_HUMAN	Homo sapiens tenascin XB (TNXB), transcript variant XB, mRNA.	1200	Fibronectin type-III 3.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACGGCCGAGCGCTGGGGTCCT	0.617000														35			29		0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	95024006	95024006	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr7:95024006C>T	uc011kih.2	-	1	120	c.95G>A	c.(94-96)cGa>cAa	p.R32Q	PON1_uc003unt.3_Missense_Mutation_p.R32Q|PON1_uc011kii.2_Missense_Mutation_p.R32Q			P27169	PON1_HUMAN	Homo sapiens paraoxonase 1 (PON1), mRNA.	32					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	CTCCACTTCTCGAGAGGCATT	0.443000														77			25		0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166211041	166211041	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr2:166211041G>A	uc002udc.3	+	16	3549	c.3259G>A	c.(3259-3261)Gtg>Atg	p.V1087M	SCN2A_uc002udd.3_Missense_Mutation_p.V1087M|SCN2A_uc002ude.3_Missense_Mutation_p.V1087M	NM_001040142	NP_066287	Q99250	SCN2A_HUMAN	Homo sapiens sodium channel, voltage-gated, type II, alpha subunit (SCN2A), transcript variant 2, mRNA.	1087					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	AAAATATGTCGTGGATGAAAG	0.378000														101			10		0	0	1	0	0
NOB1	28987	broad.mit.edu	37	16	69786144	69786144	+	Splice_Site	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr16:69786144C>T	uc002exs.3	-	3	343	c.327_splice	c.e3+1	p.K109_splice		NM_014062	NP_054781	Q9ULX3	NOB1_HUMAN	Homo sapiens NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) (NOB1), mRNA.	109						nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CTTGATTTACCTTCTGTGGTT	0.453000														74			57		0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51738423	51738423	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr19:51738423A>G	uc002pwa.2	+	4	797	c.757A>G	c.(757-759)Acc>Gcc	p.T253A	CD33_uc010eos.1_Missense_Mutation_p.T253A|CD33_uc010eot.1_Missense_Mutation_p.T126A|CD33_uc010eou.1_Non-coding_Transcript	NM_001772	NP_001763	P20138	CD33_HUMAN	Homo sapiens CD33 molecule (CD33), transcript variant 1, mRNA.	253					cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GAAACAAGAGACCAGAGCAGG	0.478000														186			5		0	0	1	0	0
RNF5P1	286140	broad.mit.edu	37	8	38458656	38458656	+	Silent	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr8:38458656C>T	uc003xly.3	-	0	120	c.63G>A	c.(61-63)gcG>gcA	p.A21A						Homo sapiens ring finger protein 5 pseudogene 1 (RNF5P1), non-coding RNA.																		AGGTCGCGCCCGCCCCGCCCC	0.627000														22			9		0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150817086	150817086	+	Splice_Site	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrX:150817086G>A	uc004fev.4	+	9	962	c.630_splice	c.e9-1	p.S210_splice		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	Homo sapiens PAS domain containing 1 (PASD1), mRNA.	210						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTTATAGTAGCTCTCAA	0.383000														272			5		0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86479790	86479790	+	Missense_Mutation	SNP	G	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr7:86479790G>T	uc003uid.3	+	4	3595	c.2496G>T	c.(2494-2496)aaG>aaT	p.K832N	GRM3_uc010lef.3_Nonsense_Mutation_p.E475*|GRM3_uc010leg.3_Missense_Mutation_p.K704N|GRM3_uc010leh.3_Missense_Mutation_p.K424N	NM_000840	NP_000831	Q14832	GRM3_HUMAN	Homo sapiens glutamate receptor, metabotropic 3 (GRM3), mRNA.	832					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AACCCCAGAAGAATGTTGTCA	0.488000														84			50		1.93748e-29	2.30076e-29	1	1	0
HS6ST2	90161	broad.mit.edu	37	X	132091342	132091342	+	Missense_Mutation	SNP	C	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrX:132091342C>A	uc011mvd.1	-	2	857	c.441G>T	c.(439-441)atG>atT	p.M147I	HS6ST2_uc011mvb.1_Missense_Mutation_p.M1I|HS6ST2_uc011mvc.1_Missense_Mutation_p.M1I|HS6ST2_uc011mve.1_Missense_Mutation_p.M147I	NM_001077188	NP_001070656	Q96MM7	H6ST2_HUMAN	Homo sapiens heparan sulfate 6-O-sulfotransferase 2 (HS6ST2), transcript variant L, mRNA.	147						integral to membrane	sulfotransferase activity			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(2)	9	Acute lymphoblastic leukemia(192;0.000127)					ATTTCTCATCCATGTTCCCGA	0.617000														103			83		8.16033e-55	1.0003e-54	1	1	0
USP9X	8239	broad.mit.edu	37	X	41029423	41029423	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrX:41029423G>A	uc004dfb.3	+	18	3445	c.2812G>A	c.(2812-2814)Ggt>Agt	p.G938S	USP9X_uc004dfc.3_Missense_Mutation_p.G938S	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	Homo sapiens ubiquitin specific peptidase 9, X-linked (USP9X), transcript variant 3, mRNA.	938					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						CTTTGTGGGCGGTGAGCTGAT	0.343000														211			4		0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121699937	121699937	+	Missense_Mutation	SNP	G	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr7:121699937G>T	uc003vjy.3	+	28	7197	c.6802G>T	c.(6802-6804)Gac>Tac	p.D2268Y	PTPRZ1_uc011knt.2_Missense_Mutation_p.D1408Y|PTPRZ1_uc003vjz.3_Missense_Mutation_p.D1401Y	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1), transcript variant 1, mRNA.	2268	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AGTCTTTGCTGACATTGTAAG	0.393000														54			33		1.90571e-15	2.12991e-15	1	1	0
IGLON5	402665	broad.mit.edu	37	19	51828628	51828628	+	Silent	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr19:51828628G>A	uc002pwc.2	+	3	420	c.420G>A	c.(418-420)tcG>tcA	p.S140S		NM_001101372	NP_001094842	A6NGN9	IGLO5_HUMAN	Homo sapiens IgLON family member 5 (IGLON5), mRNA.	140	Ig-like C2-type 2.					extracellular region				large_intestine(5)|lung(6)|prostate(1)	12						ACATCTCGTCGCCTGTGACGG	0.647000														31			31		0	0	1	0	0
LOC646214	646214	broad.mit.edu	37	15	21937915	21937915	+	RNA	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr15:21937915C>T	uc010tzj.1	-	0		c.2825G>A								Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 2 pseudogene (LOC646214), non-coding RNA.																		AATTTCTGGCCGTTCCTTTTC	0.438000														317			64		0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30963507	30963507	+	Silent	SNP	C	T	T	rs144528849		TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr21:30963507C>T	uc002yno.1	-	9	1754	c.1290G>A	c.(1288-1290)acG>acA	p.T430T	GRIK1_uc002ynn.3_Silent_p.T415T|GRIK1_uc011acs.2_Silent_p.T430T|GRIK1_uc011act.2_Silent_p.T359T|GRIK1_uc010glq.1_Silent_p.T273T	NM_000830	NP_000821	P39086	GRIK1_HUMAN	Homo sapiens glutamate receptor, ionotropic, kainate 1 (GRIK1), transcript variant 1, mRNA.	430					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity	p.T430T(1)|p.T415T(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TGTTGCTGTCCGTCATGTTAA	0.448000														49			79		0	0	1	0	0
FGG	2266	broad.mit.edu	37	4	155529663	155529663	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr4:155529663G>A	uc003ioj.3	-	6	947	c.806C>T	c.(805-807)cCa>cTa	p.P269L	FGG_uc003iog.3_Missense_Mutation_p.P269L	NM_021870	NP_068656	P02679	FIBG_HUMAN	Homo sapiens fibrinogen gamma chain (FGG), transcript variant gamma-B, mRNA.	269	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	TAATGCATATGGGATGGCAGA	0.403000														77			40		0	0	1	0	0
MARCH5	54708	broad.mit.edu	37	10	94071001	94071001	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr10:94071001C>T	uc001khx.1	+	1	477	c.145C>T	c.(145-147)Cgc>Tgc	p.R49C	MARCH5_uc010qno.1_5'UTR	NM_017824	NP_060294	Q9NX47	MARH5_HUMAN	Homo sapiens membrane-associated ring finger (C3HC4) 5 (MARCH5), mRNA.	49					cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						CTGTCTACAACGCTGGGTGGA	0.448000														27			6		0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5342510	5342510	+	Silent	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr7:5342510C>T	uc003sod.3	+	10	1694	c.1533C>T	c.(1531-1533)gaC>gaT	p.D511D	SLC29A4_uc003soc.3_Silent_p.D511D|SLC29A4_uc003soe.3_Silent_p.D497D	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	Homo sapiens solute carrier family 29 (nucleoside transporters), member 4 (SLC29A4), transcript variant 2, mRNA.	511					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		TCACCCGCGACGCTCACGGCA	0.682000														46			45		0	0	1	0	0
DHX16	8449	broad.mit.edu	37	6	30623374	30623374	+	Splice_Site	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr6:30623374C>T	uc003nqz.3	-	17	2711	c.2499_splice	c.e17-1	p.K833_splice	DHX16_uc003nqy.3_Splice_Site_p.K352_splice|DHX16_uc011dmo.2_Splice_Site_p.K773_splice	NM_003587	NP_003578	O60231	DHX16_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 16 (DHX16), transcript variant 1, mRNA.	833					RNA splicing|mRNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA helicase activity|nucleic acid binding			kidney(2)|ovary(2)	4						AACAGCTGTACCTGGGACAGG	0.498000														2			33		0	0	1	0	0
SOAT2	8435	broad.mit.edu	37	12	53517645	53517645	+	Silent	SNP	C	T	T			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr12:53517645C>T	uc001sbv.3	+	13	1594	c.1506C>T	c.(1504-1506)tgC>tgT	p.C502C	SOAT2_uc009zms.3_Non-coding_Transcript	NM_003578	NP_003569	O75908	SOAT2_HUMAN	Homo sapiens sterol O-acyltransferase 2 (SOAT2), mRNA.	502					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|macrophage derived foam cell differentiation|very-low-density lipoprotein particle assembly	brush border|endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol O-acyltransferase activity|cholesterol binding|fatty-acyl-CoA binding			endometrium(5)|kidney(3)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	18						GGCGGCACTGCCCCTTACCCC	0.612000														39			17		0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36123063	36123063	+	Splice_Site	DEL	A	-	-			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr5:36123063delA	uc003jkb.1	-	8	1238	c.823_splice	c.e8-1	p.C275_splice		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	Homo sapiens LMBR1 domain containing 2 (LMBRD2), mRNA.	275						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCTGTAGGGCACtaaaaaaaa	0.249													---	173	---	---	7	---					
SLC30A5	64924	broad.mit.edu	37	5	68390134	68390134	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr5:68390134delG	uc003jvh.3	+	0	359	c.52delG	c.(52-54)ggcfs	p.G18fs	SLC30A5_uc003jvg.3_Frame_Shift_Del_p.G18fs|SLC30A5_uc011crc.2_Frame_Shift_Del_p.G18fs	NM_022902	NP_075053	Q8TAD4	ZNT5_HUMAN	Homo sapiens solute carrier family 30 (zinc transporter), member 5 (SLC30A5), transcript variant 1, mRNA.	18	Poly-Gly.				cellular zinc ion homeostasis|cobalt ion transport|regulation of proton transport|response to zinc ion	Golgi apparatus|apical plasma membrane|integral to plasma membrane|membrane fraction|secretory granule membrane	zinc ion binding|zinc ion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Lung NSC(167;0.000986)|Prostate(74;0.00809)|Colorectal(97;0.0508)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;1.24e-56)|Epithelial(20;1.12e-52)|all cancers(19;2.63e-48)|Lung(70;0.0177)		cggcggcggcggccTTGGGCC	0.741													---	4	---	---	2	---					
CDKN1A	1026	broad.mit.edu	37	6	36652011	36652012	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr6:36652011_36652012insC	uc021yzb.1	+	2	235_236	c.133_134insC	c.(133-135)gccfs	p.A45fs	CDKN1A_uc021yzc.1_Frame_Shift_Ins_p.A45fs|CDKN1A_uc011dtq.2_Frame_Shift_Ins_p.A79fs|CDKN1A_uc003omm.4_Frame_Shift_Ins_p.A45fs|CDKN1A_uc003omn.3_Frame_Shift_Ins_p.A45fs	NM_078467	NP_510867	P38936	CDN1A_HUMAN	Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2, mRNA.	45					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|Ras protein signal transduction|S phase of mitotic cell cycle|cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|stress-induced premature senescence	PCNA-p21 complex|cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						CATCCAGGAGGCCCGTGAGCGA	0.658													---	6	---	---	22	---					
ZNF34	80778	broad.mit.edu	37	8	145999670	145999670	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr8:145999670delT	uc003zdy.4	-	5	766	c.664delA	c.(664-666)acafs	p.T222fs	ZNF34_uc010mgb.3_Frame_Shift_Del_p.T119fs|ZNF34_uc003zdx.4_Frame_Shift_Del_p.T201fs	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	Homo sapiens zinc finger protein 34 (ZNF34), mRNA.	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(1)	11	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		ACTGTATTTGTTTTTTTTGAC	0.353													---	204	---	---	8	---					
TAS2R30	259293	broad.mit.edu	37	12	11286136	11286137	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chr12:11286136_11286137insA	uc009zhs.1	-	0	707_708	c.707_708insT	c.(706-708)ctgfs	p.L236fs	PRH1_uc001qzb.4_Intron|TAS2R14_uc021qve.1_Intron|PRH1_uc021qvg.1_Intron|PRB4_uc001qzf.1_Intron|TAS2R14_uc001qzj.3_Intron	NM_001097643	NP_001091112			Homo sapiens taste receptor, type 2, member 30 (TAS2R30), mRNA.											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	13						TGGCACATAACAGAAGAAAGGA	0.411													---	259	---	---	8	---					
ARSF	416	broad.mit.edu	37	X	2986145	2986145	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KL-8331-01A-11D-2310-10	TCGA-KL-8331-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7087a2b6-7fc4-45b0-8c48-248864f03deb	2ca67854-9fef-4b3e-a4e0-0432df5a5800	g.chrX:2986145delA	uc022brz.1	+	1	140	c.4delA	c.(4-6)aggfs	p.R2fs	ARSF_uc004cre.2_Frame_Shift_Del_p.R2fs|ARSF_uc004crf.2_Frame_Shift_Del_p.R2fs	NM_001201538	NP_001188467	P54793	ARSF_HUMAN	Homo sapiens arylsulfatase F (ARSF), transcript variant 2, mRNA.	2						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTGCACAATGAGGCCCAGGTA	0.363													---	475	---	---	7	---					
