Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GBX2	2637	broad.mit.edu	37	2	237074936	237074936	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr2:237074936T>C	uc002vvw.1	-	1	706	c.668A>G	c.(667-669)gAc>gGc	p.D223G	GBX2_uc010zng.1_3'UTR	NM_001485	NP_001476	P52951	GBX2_HUMAN	Homo sapiens gastrulation brain homeobox 2 (GBX2), mRNA.	223				QAAHKEEDPGHALEETPPSSGA -> PGSSQGGRPGPRGGG DPAEQRR (in Ref. 6).		nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Breast(86;0.00235)|Renal(207;0.00339)|all_hematologic(139;0.00357)|all_lung(227;0.0616)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|Lung NSC(271;0.179)		Epithelial(121;4.5e-25)|OV - Ovarian serous cystadenocarcinoma(60;5.16e-11)|BRCA - Breast invasive adenocarcinoma(100;3.4e-05)|Lung(119;0.00195)|LUSC - Lung squamous cell carcinoma(224;0.00471)		GTGGCCCGGGTCTTCCTCCTT	0.677000														30			3		0	0	1	0	0
UBA1	7317	broad.mit.edu	37	X	47062169	47062169	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chrX:47062169A>G	uc004dhj.4	+	10	1340	c.1189A>G	c.(1189-1191)Ata>Gta	p.I397V	UBA1_uc004dhk.4_Missense_Mutation_p.I397V|INE1_uc004dhl.3_5'Flank	NM_153280	NP_695012	P22314	UBA1_HUMAN	Homo sapiens ubiquitin-like modifier activating enzyme 1 (UBA1), transcript variant 2, mRNA.	397	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TCTGGCACCCATAAACGCCTT	0.602000														60			7		0	0	1	0	0
RILPL1	353116	broad.mit.edu	37	12	123957223	123957223	+	Missense_Mutation	SNP	G	T	T			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr12:123957223G>T	uc001ufe.2	-	6	1310	c.1074C>A	c.(1072-1074)agC>agA	p.S358R	RILPL1_uc001ufd.2_Missense_Mutation_p.S207R|RILPL1_uc010tas.1_3'UTR	NM_178314	NP_847884	Q5EBL4	RIPL1_HUMAN	Homo sapiens Rab interacting lysosomal protein-like 1 (RILPL1), mRNA.	358					neuroprotection	cytosol		p.S358R(6)		endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		GGGAGAAGAAGCTAAACCTTT	0.498000														75			7		0.000157383	0.000157383	1	1	0
KIAA1009	22832	broad.mit.edu	37	6	84884491	84884491	+	Silent	SNP	T	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr6:84884491T>C	uc010kbp.3	-	14	2077	c.1980A>G	c.(1978-1980)aaA>aaG	p.K660K	KIAA1009_uc003pkj.4_Silent_p.K584K|KIAA1009_uc003pkk.2_3'UTR|KIAA1009_uc003pki.4_Silent_p.K46K	NM_014895	NP_055710	Q5TB80	QN1_HUMAN	Homo sapiens KIAA1009 (KIAA1009), mRNA.	660					cell division|mitosis	centrosome|nucleus|plasma membrane|spindle	protein binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	43		all_cancers(76;1.5e-06)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00258)		BRCA - Breast invasive adenocarcinoma(397;0.089)		TGAAGAGTTCTTTTTCCTGTT	0.303000														102			4		0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	A	A	rs143435240	byFrequency	TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chrX:51076024G>A	uc004dph.3	+	1	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_uc004dpi.4_Silent_p.E69E	NM_153183	NP_694853	Q8NFP7	NUD10_HUMAN	Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 10 (NUDT10), mRNA.	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(16)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000														108			4		0	0	1	0	0
PRKCDBP	112464	broad.mit.edu	37	11	6341681	6341681	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr11:6341681C>T	uc001mcu.1	-	0	60	c.26G>A	c.(25-27)gGg>gAg	p.G9E		NM_145040	NP_659477	Q969G5	PRDBP_HUMAN	Homo sapiens protein kinase C, delta binding protein (PRKCDBP), mRNA.	9										large_intestine(3)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	9		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GGGCACAGGCCCCCGCTCCAA	0.701000														38			13		0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88652217	88652217	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr14:88652217C>T	uc001xwm.3	-	6	1416	c.1294G>A	c.(1294-1296)Ggg>Agg	p.G432R	KCNK10_uc001xwn.3_Missense_Mutation_p.G432R|KCNK10_uc001xwo.3_Missense_Mutation_p.G427R	NM_138318	NP_612191	P57789	KCNKA_HUMAN	Homo sapiens potassium channel, subfamily K, member 10 (KCNK10), transcript variant 3, mRNA.	427					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						TGCTCCGGCCCCTTCAGGCGC	0.597000														122			4		0	0	1	0	0
HERC2P2	400322	broad.mit.edu	37	15	23308703	23308703	+	RNA	SNP	T	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr15:23308703T>C	uc001yvq.2	-	1		c.1036A>G			HERC2P2_uc001yvo.4_Non-coding_Transcript|HERC2P2_uc001yvp.4_Non-coding_Transcript					Homo sapiens hect domain and RLD 2 pseudogene 2 (HERC2P2), non-coding RNA.																		CCAGGTCCACTTGTCCTGCGG	0.602000														106			4		0	0	1	0	0
DYX1C1	161582	broad.mit.edu	37	15	55731737	55731737	+	Missense_Mutation	SNP	C	A	A			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr15:55731737C>A	uc002adc.3	-	6	1194	c.826G>T	c.(826-828)Gac>Tac	p.D276Y	CCPG1_uc002acy.3_5'UTR|CCPG1_uc010ugh.1_Non-coding_Transcript|CCPG1_uc010ugi.2_Non-coding_Transcript|DYX1C1_uc002adb.3_Missense_Mutation_p.D276Y|DYX1C1_uc002add.3_Missense_Mutation_p.D276Y	NM_130810	NP_570722	Q8WXU2	DYXC1_HUMAN	Homo sapiens dyslexia susceptibility 1 candidate 1 (DYX1C1), transcript variant 1, mRNA.	276					neuron migration|regulation of estrogen receptor signaling pathway|regulation of proteasomal protein catabolic process	cytoplasm|nucleus	estrogen receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18				all cancers(107;0.0118)|GBM - Glioblastoma multiforme(80;0.171)		TCAGCTATGTCAGTATTCATT	0.338000														110			7		1.06961e-07	1.10781e-07	1	1	0
MYBPHL	343263	broad.mit.edu	37	1	109840181	109840181	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr1:109840181C>T	uc001dxk.1	-	2	343	c.293G>A	c.(292-294)cGt>cAt	p.R98H	MYBPHL_uc010ovh.1_Missense_Mutation_p.R98H|MYBPHL_uc001dxl.3_Intron	NM_001010985	NP_001010985	A2RUH7	MBPHL_HUMAN	Homo sapiens myosin binding protein H-like (MYBPHL), mRNA.	98	Ig-like C2-type 1.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		CACACTCACACGCCTGGTGTC	0.587000														62			4		0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248343935	248343935	+	Silent	SNP	T	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr1:248343935T>C	uc010pzf.2	+	0	648	c.648T>C	c.(646-648)gcT>gcC	p.A216A		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily M, member 2 (OR2M2), mRNA.	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCATCATTGCTTCCTATGCTC	0.438000														174			6		0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107773293	107773293	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr8:107773293T>C	uc003ymm.4	-	1	1172	c.1118A>G	c.(1117-1119)gAc>gGc	p.D373G		NM_139166	NP_631905	Q8N0Z2	ABRA_HUMAN	Homo sapiens actin-binding Rho activating protein (ABRA), mRNA.	373	Interaction with actin (By similarity).				positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CACAACATGGTCATCTCGGCC	0.418000														122			4		0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23825129	23825129	+	Silent	SNP	A	G	G			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr7:23825129A>G	uc003sws.4	+	17	2248	c.2181A>G	c.(2179-2181)gaA>gaG	p.E727E	STK31_uc003swt.4_Silent_p.E704E|STK31_uc011jze.2_Silent_p.E727E|STK31_uc010kuq.3_Silent_p.E704E|STK31_uc003swv.1_5'Flank	NM_031414	NP_116562	Q9BXU1	STK31_HUMAN	Homo sapiens serine/threonine kinase 31 (STK31), transcript variant 1, mRNA.	727	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGAGCTTGGAACGAGATCTTC	0.403000														126			4		0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206037069	206037069	+	Silent	SNP	G	A	A			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr2:206037069G>A	uc002var.2	+	11	1962	c.1755G>A	c.(1753-1755)caG>caA	p.Q585Q	PARD3B_uc010fub.2_Silent_p.Q585Q|PARD3B_uc002vao.2_Silent_p.Q585Q|PARD3B_uc002vap.2_Silent_p.Q523Q|PARD3B_uc002vaq.2_Silent_p.Q585Q	NM_205863	NP_689739	Q8TEW8	PAR3L_HUMAN	Homo sapiens par-3 partitioning defective 3 homolog B (C. elegans) (PARD3B), mRNA.	585	PDZ 3.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GGATGATCCAGTTGGTGATTC	0.488000														76			5		0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1821161	1821161	+	Silent	SNP	G	A	A			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr4:1821161G>A	uc003gdv.3	-	10	1944	c.1647C>T	c.(1645-1647)agC>agT	p.S549S		NM_012318	NP_036450	O95202	LETM1_HUMAN	Homo sapiens leucine zipper-EF-hand containing transmembrane protein 1 (LETM1), nuclear gene encoding mitochondrial protein, mRNA.	549					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			AGCAGGCATCGCTGAGGATGT	0.532000														55			14		0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079280	22079280	+	Silent	SNP	G	T	T			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr8:22079280G>T	uc003xbk.4	-	5	1273	c.579C>A	c.(577-579)ggC>ggA	p.G193G	PHYHIP_uc003xbj.4_Silent_p.G193G	NM_001099335	NP_055574	Q92561	PHYIP_HUMAN	Homo sapiens phytanoyl-CoA 2-hydroxylase interacting protein (PHYHIP), transcript variant 1, mRNA.	193										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		GCGGGGGCTGGCCCGTGTTGA	0.622000														65			8		6.5536e-12	7.03905e-12	1	1	0
RANBP6	26953	broad.mit.edu	37	9	6012658	6012658	+	Missense_Mutation	SNP	T	G	G			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr9:6012658T>G	uc003zjr.3	-	0	2983	c.2950A>C	c.(2950-2952)Ata>Cta	p.I984L	RANBP6_uc011lmf.2_Missense_Mutation_p.I632L|RANBP6_uc003zjs.3_3'UTR	NM_012416	NP_036548	O60518	RNBP6_HUMAN	Homo sapiens RAN binding protein 6 (RANBP6), transcript variant 1, mRNA.	984					protein transport	cytoplasm|nucleus	binding	p.I984L(8)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTTCCCTATTGCTGAGATA	0.363000														179			5		0	0	1	0	0
NHP2	55651	broad.mit.edu	37	5	177580963	177580963	+	Splice_Site	SNP	G	A	A			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr5:177580963G>A	uc003mir.2	-	1	1	c.-142_splice	c.e1-1		NHP2_uc003mis.2_Splice_Site	NM_017838	NP_060308	Q9NX24	NHP2_HUMAN	Homo sapiens NHP2 ribonucleoprotein homolog (yeast) (NHP2), transcript variant 1, mRNA.						rRNA pseudouridine synthesis	Cajal body|nucleolus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			endometrium(1)|kidney(1)|ovary(2)	4						CAGCCCAATCGTTGACGCCCA	0.602000														19			3		0	0	1	0	0
CAPN5	726	broad.mit.edu	37	11	76804733	76804733	+	Silent	SNP	C	T	T			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr11:76804733C>T	uc009yup.3	+	3	476	c.291C>T	c.(289-291)atC>atT	p.I97I	CAPN5_uc001oxx.3_Silent_p.I57I|CAPN5_uc009yuq.3_Silent_p.I93I|CAPN5_uc001oxy.3_Silent_p.I97I	NM_004055	NP_004046	O15484	CAN5_HUMAN	Homo sapiens calpain 5 (CAPN5), mRNA.	57	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						CGCAGGGCATCTGCGAGGACC	0.637000														30			3		0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76714238	76714238	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr5:76714238A>G	uc003kfa.3	+	17	2141	c.2096A>G	c.(2095-2097)gAc>gGc	p.D699G	PDE8B_uc003kfd.3_Missense_Mutation_p.D652G|PDE8B_uc003kfe.3_Missense_Mutation_p.D602G|PDE8B_uc003kfb.3_Missense_Mutation_p.D679G|PDE8B_uc003kfc.3_Missense_Mutation_p.D644G	NM_003719	NP_003710	O95263	PDE8B_HUMAN	Homo sapiens phosphodiesterase 8B (PDE8B), transcript variant 1, mRNA.	699	Catalytic (By similarity).				cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		ACGGTCAAGGACACCAAATGC	0.483000														124			5		0	0	1	0	0
CPNE7	27132	broad.mit.edu	37	16	89649860	89649860	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr16:89649860A>G	uc002fnp.3	+	3	636	c.506A>G	c.(505-507)gAc>gGc	p.D169G	CPNE7_uc002fnq.3_Intron	NM_014427	NP_055242	Q9UBL6	CPNE7_HUMAN	Homo sapiens copine VII (CPNE7), transcript variant 2, mRNA.	169					lipid metabolic process		transporter activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(2)	17		all_hematologic(23;0.0748)		all cancers(4;3.63e-08)|OV - Ovarian serous cystadenocarcinoma(4;1.7e-06)|BRCA - Breast invasive adenocarcinoma(80;0.0147)		aggtatgatgacctctgcctc	0.642000														114			4		0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125074107	125074107	+	Silent	SNP	C	T	T			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr8:125074107C>T	uc003yqw.3	+	24	3368	c.3162C>T	c.(3160-3162)aaC>aaT	p.N1054N	AK057332_uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	Homo sapiens fer-1-like 6 (C. elegans) (FER1L6), mRNA.	1054	C2 4.					integral to membrane		p.E1053K(1)		NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGCCTGAGAACGAGCTTCTGC	0.572000														60			11		0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169842725	169842725	+	Silent	SNP	A	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr2:169842725A>C	uc002ueo.1	-	9	1104	c.978T>G	c.(976-978)acT>acG	p.T326T		NM_003742	NP_003733	O95342	ABCBB_HUMAN	Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), mRNA.	326	ABC transmembrane type-1 1.				bile acid biosynthetic process	Golgi membrane|apical plasma membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ACACGAATCCAGTAAAGAATC	0.443000														108			8		0	0	1	0	0
MAP7D1	55700	broad.mit.edu	37	1	36643614	36643614	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr1:36643614G>A	uc001bzz.3	+	8	1736	c.1520G>A	c.(1519-1521)cGg>cAg	p.R507Q	MAP7D1_uc001caa.3_Missense_Mutation_p.R475Q|MAP7D1_uc001cab.3_Missense_Mutation_p.R470Q|MAP7D1_uc001cac.3_Missense_Mutation_p.R207Q|MAP7D1_uc001cad.3_Missense_Mutation_p.R53Q	NM_018067	NP_060537	Q3KQU3	MA7D1_HUMAN	Homo sapiens MAP7 domain containing 1 (MAP7D1), mRNA.	507	Pro-rich.					cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				CCCAAGGGGCGGGTTCGGAGG	0.692000														55			7		0	0	1	0	0
CCDC157	550631	broad.mit.edu	37	22	30766573	30766573	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr22:30766573G>A	uc011aku.2	+	4	1339	c.679G>A	c.(679-681)Gtc>Atc	p.V227I	CCDC157_uc011akv.2_Missense_Mutation_p.V227I	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	Homo sapiens coiled-coil domain containing 157 (CCDC157), mRNA.	227										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						ATGCGCCAGCGTCCAGGGAAG	0.617000														124			4		0	0	1	0	0
USP21	27005	broad.mit.edu	37	1	161132827	161132827	+	Missense_Mutation	SNP	C	T	T	rs148729808	byFrequency	TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr1:161132827C>T	uc010pkc.2	+	6	1389	c.1012C>T	c.(1012-1014)Cgc>Tgc	p.R338C	USP21_uc010pkd.2_Missense_Mutation_p.R338C|USP21_uc021pbv.1_5'Flank	NM_001014443	NP_036607	Q9UK80	UBP21_HUMAN	Homo sapiens ubiquitin specific peptidase 21 (USP21), transcript variant 3, mRNA.	338					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	NEDD8-specific protease activity|metal ion binding|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.R338H(1)		breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|ovary(3)|prostate(3)	29	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CTCTCCACCCCGCCGAGGAGG	0.557000														80			3		0	0	1	0	0
ZMYM5	9205	broad.mit.edu	37	13	20426257	20426257	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr13:20426257T>C	uc010tcn.1	-	2	329	c.64A>G	c.(64-66)Atg>Gtg	p.M22V	ZMYM5_uc001umm.1_5'UTR|ZMYM5_uc001umn.3_Missense_Mutation_p.M22V|ZMYM5_uc001umo.3_Missense_Mutation_p.M22V	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	Homo sapiens zinc finger, MYM-type 5 (ZMYM5), transcript variant 3, mRNA.	22						nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		GCCATGGCCATATTCCCTAAT	0.413000														61			3		0	0	1	0	0
LETM1	3954	broad.mit.edu	37	4	1821162	1821162	+	Missense_Mutation	SNP	C	G	G			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr4:1821162C>G	uc003gdv.3	-	10	1943	c.1646G>C	c.(1645-1647)aGc>aCc	p.S549T		NM_012318	NP_036450	O95202	LETM1_HUMAN	Homo sapiens leucine zipper-EF-hand containing transmembrane protein 1 (LETM1), nuclear gene encoding mitochondrial protein, mRNA.	549					cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			GCAGGCATCGCTGAGGATGTC	0.532000														54			14		0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135429078	135429078	+	Silent	SNP	T	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chrX:135429078T>C	uc004ezu.1	+	5	3504	c.3213T>C	c.(3211-3213)gcT>gcC	p.A1071A	GPR112_uc010nsb.1_Silent_p.A866A|GPR112_uc010nsc.1_Silent_p.A838A	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	Homo sapiens G protein-coupled receptor 112 (GPR112), mRNA.	1071					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.T1070N(1)		NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ATCAGACTGCTTCCACAACCA	0.473000														91			4		0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4228459	4228459	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr4:4228459delG	uc003ghp.1	-	0	163	c.133delC	c.(133-135)cggfs	p.R45fs		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	Homo sapiens otopetrin 1 (OTOP1), mRNA.	45					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ccgccccgccggggggccggg	0.736													---	4	---	---	2	---					
LIMK1	3984	broad.mit.edu	37	7	73535525	73535526	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr7:73535525_73535526insC	uc003uaa.2	+	15	2052_2053	c.1838_1839insC	c.(1837-1839)ggcfs	p.G613fs	LIMK1_uc010lbl.2_Non-coding_Transcript|LIMK1_uc003uab.3_Frame_Shift_Ins_p.G579fs	NM_002314	NP_002305	P53667	LIMK1_HUMAN	Homo sapiens LIM domain kinase 1 (LIMK1), transcript variant 1, mRNA.	613					Rho protein signal transduction|actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CACCTGGCCGGCCACCTGCCAC	0.683													---	108	---	---	7	---					
PRIC285	85441	broad.mit.edu	37	20	62194557	62194557	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KL-8333-01A-11D-2310-10	TCGA-KL-8333-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c56505cb-e150-408d-9df6-3af4e608c376	422375ba-7c98-42a5-b8cc-f88084a938f6	g.chr20:62194557delA	uc002yfm.2	-	8	6510	c.5618delT	c.(5617-5619)gtgfs	p.V1873fs	PRIC285_uc002yfl.1_Frame_Shift_Del_p.V1304fs	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	Homo sapiens peroxisomal proliferator-activated receptor A interacting complex 285 (PRIC285), transcript variant 1, mRNA.	1873				V -> A (in Ref. 2; BAE46995).	cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|RNA binding|helicase activity|ribonuclease activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(4)|cervix(3)|endometrium(6)|kidney(3)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(4)|urinary_tract(2)	47	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			CTCCCGGGCCACCTCCAGGAA	0.701													---	4	---	---	2	---					
