Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TTC19	54902	broad.mit.edu	37	17	15930770	15930770	+	Silent	SNP	C	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr17:15930770C>T	uc002gph.2	+	9	1546	c.1440C>T	c.(1438-1440)caC>caT	p.H480H	TTC19_uc021tqp.1_Non-coding_Transcript|TTC19_uc002gpk.4_3'UTR|TTC19_uc002gpj.3_Silent_p.H122H	NM_017775	NP_060245	Q6DKK2	TTC19_HUMAN	Homo sapiens tetratricopeptide repeat domain 19 (TTC19), transcript variant 1, mRNA.	359					cell cycle|cytokinesis|mitochondrial respiratory chain complex III assembly	centrosome|midbody|mitochondrial inner membrane	protein binding			central_nervous_system(1)|lung(2)|skin(1)|stomach(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CTGTACAACACATCAGGGAAG	0.378000														78			37		0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481375	123481375	+	Missense_Mutation	SNP	T	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr12:123481375T>G	uc001uej.1	-	10	1754	c.1555A>C	c.(1555-1557)Acc>Ccc	p.T519P	PITPNM2_uc001uek.1_Missense_Mutation_p.T519P	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	Homo sapiens phosphatidylinositol transfer protein, membrane-associated 2 (PITPNM2), mRNA.	519					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GGGGAGGAGGTGGCCAGCAGG	0.622000														89			7		0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123160846	123160846	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr4:123160846G>A	uc003ieh.3	+	26	4054	c.4009G>A	c.(4009-4011)Gtt>Att	p.V1337I	KIAA1109_uc003iei.1_Missense_Mutation_p.V1090I|KIAA1109_uc010ins.1_Missense_Mutation_p.V680I|KIAA1109_uc003iek.2_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	Homo sapiens KIAA1109 (KIAA1109), mRNA.	1337					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GCCTGTAACAGTTGGAGTCCA	0.453000														153			69		0	0	1	0	0
RAPGEF1	2889	broad.mit.edu	37	9	134504010	134504010	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr9:134504010T>C	uc022bos.1	-	7	1105	c.946A>G	c.(946-948)Acc>Gcc	p.T316A	RAPGEF1_uc022bot.1_Missense_Mutation_p.T298A|RAPGEF1_uc010mzm.3_5'Flank|RAPGEF1_uc022bou.1_Missense_Mutation_p.T303A|RAPGEF1_uc022bov.1_Missense_Mutation_p.T303A	NM_198679	NP_941372	Q13905	RPGF1_HUMAN	Homo sapiens Rap guanine nucleotide exchange factor (GEF) 1 (RAPGEF1), transcript variant 2, mRNA.	298					activation of MAPKK activity|nerve growth factor receptor signaling pathway|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|endosome	SH3 domain binding|guanyl-nucleotide exchange factor activity			NS(2)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	39		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.19e-05)|Epithelial(140;0.000364)		GCCACTCGGGTAGGGGACGGC	0.587000														85			4		0	0	1	0	0
DCDC5	100506627	broad.mit.edu	37	11	30942461	30942461	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr11:30942461C>T	uc009yjk.1	-	12	1568	c.1499G>A	c.(1498-1500)aGt>aAt	p.S500N	DCDC5_uc001mss.1_Non-coding_Transcript|DCDC5_uc021qfk.1_Missense_Mutation_p.S159N	NM_020869	NP_065920	Q6ZRR9	DCDC5_HUMAN	Homo sapiens doublecortin domain containing 5 (DCDC5), mRNA.	131	Doublecortin 2.				intracellular signal transduction					NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(17)|prostate(1)|stomach(1)	31						TACAATGTCACTTTGGACTTC	0.363000														124			75		0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53586752	53586752	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr8:53586752T>C	uc003xre.4	-	6	1213	c.655A>G	c.(655-657)Aga>Gga	p.R219G	RB1CC1_uc003xrf.4_Missense_Mutation_p.R219G	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Homo sapiens RB1-inducible coiled-coil 1 (RB1CC1), transcript variant 1, mRNA.	219					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ULK1-ATG13-FIP200 complex|cytosol|nucleus|pre-autophagosomal structure	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				GAATCCAGTCTTCCCAAACAT	0.403000														220			5		0	0	1	0	0
GBP2	2634	broad.mit.edu	37	1	89585913	89585913	+	Missense_Mutation	SNP	A	C	C			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr1:89585913A>C	uc001dmz.1	-	3	648	c.377T>G	c.(376-378)tTc>tGc	p.F126C	GBP2_uc001dmy.1_Non-coding_Transcript	NM_004120	NP_004111	P32456	GBP2_HUMAN	Homo sapiens guanylate binding protein 2, interferon-inducible (GBP2), mRNA.	126					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		ATTGTACACGAAGGTGCTGCT	0.463000														90			4		0	0	1	0	0
OSBPL5	114879	broad.mit.edu	37	11	3114269	3114269	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr11:3114269C>T	uc001lxk.2	-	17	2118	c.1960G>A	c.(1960-1962)Gtc>Atc	p.V654I	OSBPL5_uc010qxq.1_Missense_Mutation_p.V565I|OSBPL5_uc009ydw.2_Missense_Mutation_p.V586I|OSBPL5_uc001lxl.2_Missense_Mutation_p.V586I|OSBPL5_uc001lxj.2_Missense_Mutation_p.V108I	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	Homo sapiens oxysterol binding protein-like 5 (OSBPL5), transcript variant 1, mRNA.	654					Golgi to plasma membrane transport|cholesterol metabolic process|cholesterol transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GCCCTGGTGACGTGCTGCCAG	0.682000														63			6		0	0	1	0	0
OR11H12	440153	broad.mit.edu	37	14	19377804	19377804	+	Missense_Mutation	SNP	C	A	A			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr14:19377804C>A	uc010tkp.2	+	0	211	c.211C>A	c.(211-213)Cac>Aac	p.H71N		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	Homo sapiens olfactory receptor, family 11, subfamily H, member 12 (OR11H12), mRNA.	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGGCGACTTCACACTCCCAT	0.418000														160			101		1.19595e-37	1.23453e-37	1	1	0
PAX3	5077	broad.mit.edu	37	2	223066834	223066834	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr2:223066834C>T	uc010fwo.3	-	7	1630	c.1249G>A	c.(1249-1251)Ggg>Agg	p.G417R	PAX3_uc002vmt.2_Missense_Mutation_p.G417R|PAX3_uc002vmy.2_Missense_Mutation_p.G416R|PAX3_uc002vmv.2_Missense_Mutation_p.G417R|PAX3_uc002vmw.2_Intron|PAX3_uc002vmx.2_Intron	NM_181457	NP_852122	P23760	PAX3_HUMAN	Homo sapiens paired box 3 (PAX3), transcript variant PAX3, mRNA.	417					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCAGACCCCCGGTGAGAGGG	0.557000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome							145			4		0	0	1	0	0
FAM35B2	439965	broad.mit.edu	37	10	47380033	47380033	+	RNA	SNP	G	A	A			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr10:47380033G>A	uc010qfz.2	+	0		c.314G>A								Homo sapiens family with sequence similarity 35, member B2 (pseudogene) (FAM35B2), non-coding RNA.																		ACAGAATATAGAATCCCAGAA	0.368000														137			5		0	0	1	0	0
TFAP2C	7022	broad.mit.edu	37	20	55208518	55208518	+	Silent	SNP	G	A	A	rs146916115	byFrequency	TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr20:55208518G>A	uc002xya.3	+	3	939	c.696G>A	c.(694-696)tcG>tcA	p.S232S	TFAP2C_uc010zzi.2_Silent_p.S63S	NM_003222	NP_003213	Q92754	AP2C_HUMAN	Homo sapiens transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) (TFAP2C), mRNA.	232					cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			Colorectal(105;0.229)			GAAGATTGTCGCTCCTCAGCT	0.537000														202			12		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118680	118680	+	RNA	SNP	T	C	C			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chrGL000205.1:118680T>C	uc002kgk.4	+	0		c.2058T>C								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GTGTGATTTATTAACGCCCAA	0.378000														14			3		0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183791547	183791547	+	Silent	SNP	A	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr2:183791547A>G	uc002upc.3	-	29	3669	c.3267T>C	c.(3265-3267)gaT>gaC	p.D1089D	NCKAP1_uc002upb.3_Silent_p.D1095D	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	Homo sapiens NCK-associated protein 1 (NCKAP1), transcript variant 1, mRNA.	1089					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GACTTACCATATCTAGCAGTA	0.318000														80			3		0	0	1	0	0
GGNBP2	79893	broad.mit.edu	37	17	34942391	34942391	+	Silent	SNP	A	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr17:34942391A>G	uc002hnb.3	+	10	1804	c.1488A>G	c.(1486-1488)gaA>gaG	p.E496E	GGNBP2_uc002hna.3_3'UTR|GGNBP2_uc002hnc.1_Silent_p.E325E	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	Homo sapiens gametogenetin binding protein 2 (GGNBP2), mRNA.	496					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle		p.E496E(2)		breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		ATCATGATGAACACGGTAGGC	0.413000														75			4		0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22575373	22575373	+	Missense_Mutation	SNP	C	T	T	rs140852501	by1000genomes	TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr19:22575373C>T	uc002nqt.2	-	3	786	c.664G>A	c.(664-666)Gcc>Acc	p.A222T		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	Homo sapiens zinc finger protein 98 (ZNF98), mRNA.	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				AGGTTTGAGGCCTCATTATAG	0.383000														337			7		0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70161181	70161181	+	Silent	SNP	C	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr16:70161181C>T	uc002eyf.1	+	3	1203	c.246C>T	c.(244-246)acC>acT	p.T82T	CLEC18A_uc002exy.3_Intron|PDPR_uc010vlr.1_5'UTR	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	Homo sapiens pyruvate dehydrogenase phosphatase regulatory subunit (PDPR), mRNA.	82					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		CTGGCTCTACCAGGTTCTGTG	0.463000														326			51		0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42034895	42034895	+	Silent	SNP	A	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr15:42034895A>G	uc010ucy.2	+	14	4918	c.4737A>G	c.(4735-4737)acA>acG	p.T1579T	MGA_uc010ucz.2_Intron|MGA_uc010uda.1_Silent_p.T195T	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	Homo sapiens MAX gene associated (MGA), transcript variant 1, mRNA.	1579						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGGTCGTCACACCTGTGGTTT	0.502000														52			30		0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48812976	48812976	+	Missense_Mutation	SNP	C	T	T	rs146726731	byFrequency	TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr15:48812976C>T	uc001zwx.2	-	9	1422	c.1027G>A	c.(1027-1029)Ggg>Agg	p.G343R		NM_000138	NP_000129	P35555	FBN1_HUMAN	Homo sapiens fibrillin 1 (FBN1), mRNA.	343	TB 2.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GAGCAGCGCCCGTTTGTCAGA	0.517000														70			3		0	0	1	0	0
TALDO1	6888	broad.mit.edu	37	11	763428	763428	+	Silent	SNP	T	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr11:763428T>G	uc001lqz.3	+	4	596	c.546T>G	c.(544-546)ggT>ggG	p.G182G	TALDO1_uc001lra.3_Silent_p.G182G	NM_006755	NP_006746	P37837	TALDO_HUMAN	Homo sapiens transaldolase 1 (TALDO1), mRNA.	182					energy reserve metabolic process|xylulose biosynthetic process	cytosol	protein binding|sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity			breast(1)|kidney(2)|large_intestine(5)|lung(4)|prostate(2)	14		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;4.66e-26)|Epithelial(43;2.97e-25)|OV - Ovarian serous cystadenocarcinoma(40;1.48e-19)|BRCA - Breast invasive adenocarcinoma(625;4.41e-05)|Lung(200;0.0595)|LUSC - Lung squamous cell carcinoma(625;0.0712)		CCGAGGCGGGTGTGACCCTCA	0.607000														61			7		0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579183	82579183	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr7:82579183T>C	uc003uhx.2	-	5	11010	c.10721A>G	c.(10720-10722)gAc>gGc	p.D3574G	PCLO_uc003uhv.2_Missense_Mutation_p.D3574G|PCLO_uc010lec.3_Missense_Mutation_p.D539G	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 1, mRNA.	3505					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACTTTGTGTGTCTGAATCTGC	0.443000														159			4		0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202391786	202391786	+	Missense_Mutation	SNP	A	G	G	rs141572166		TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr1:202391786A>G	uc001gya.2	+	2	611	c.461A>G	c.(460-462)aAt>aGt	p.N154S	PPP1R12B_uc001gxy.3_Missense_Mutation_p.N154S|PPP1R12B_uc009xae.2_Missense_Mutation_p.N154S|PPP1R12B_uc009xad.2_Intron	NM_002481	NP_002472	O60237	MYPT2_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 12B (PPP1R12B), transcript variant 1, mRNA.	154					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			GGTATTGTCAATAGTGAAGGT	0.418000														168			5		0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152191466	152191466	+	Missense_Mutation	SNP	C	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr1:152191466C>T	uc001ezt.1	-	2	2715	c.2639G>A	c.(2638-2640)cGc>cAc	p.R880H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	Homo sapiens hornerin (HRNR), mRNA.	880					keratinization		calcium ion binding|protein binding	p.R880H(2)		autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGTCGGCCGCGGCCCGAAGC	0.627000														66			3		0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96646519	96646519	+	RNA	SNP	T	A	A			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr2:96646519T>A	uc010yug.1	-	4		c.693A>T								Homo sapiens cDNA FLJ54441 complete cds, highly similar to Homo sapiens ankyrin repeat domain 36 (ANKRD36), mRNA.									p.H203L(2)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						AGTAACAGCATGTATGAGGGC	0.313000														309			5		0	0	1	0	0
OPRD1	4985	broad.mit.edu	37	1	29189494	29189494	+	Missense_Mutation	SNP	G	A	A			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr1:29189494G>A	uc001brf.1	+	2	1060	c.818G>A	c.(817-819)tGt>tAt	p.C273Y		NM_000911	NP_000902	P41143	OPRD_HUMAN	Homo sapiens opioid receptor, delta 1 (OPRD1), mRNA.	273					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	TTCGTGGTGTGTTGGGCGCCC	0.677000														40			27		0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63851395	63851395	+	Missense_Mutation	SNP	A	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr10:63851395A>G	uc001jlt.2	+	9	2629	c.2173A>G	c.(2173-2175)Agg>Ggg	p.R725G	ARID5B_uc001jlu.2_Missense_Mutation_p.R482G	NM_032199	NP_115575	Q14865	ARI5B_HUMAN	Homo sapiens AT rich interactive domain 5B (MRF1-like) (ARID5B), transcript variant 1, mRNA.	725					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					ACTGATTGCTAGGGATGACTT	0.527000														47			3		0	0	1	0	0
SYBU	55638	broad.mit.edu	37	8	110587964	110587964	+	Missense_Mutation	SNP	A	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr8:110587964A>T	uc010mcp.3	-	7	1525	c.1163T>A	c.(1162-1164)cTg>cAg	p.L388Q	SYBU_uc003yni.4_Missense_Mutation_p.L385Q|SYBU_uc003ynk.4_Missense_Mutation_p.L269Q|SYBU_uc003ynj.4_Missense_Mutation_p.L388Q|SYBU_uc010mco.3_Missense_Mutation_p.L387Q|SYBU_uc003ynl.4_Missense_Mutation_p.L387Q|SYBU_uc010mcq.3_Missense_Mutation_p.L388Q|SYBU_uc003yno.4_Missense_Mutation_p.L269Q|SYBU_uc010mcr.3_Missense_Mutation_p.L388Q|SYBU_uc003ynm.4_Missense_Mutation_p.L387Q|SYBU_uc003ynn.4_Missense_Mutation_p.L387Q|SYBU_uc010mcs.3_Missense_Mutation_p.L269Q|SYBU_uc010mct.3_Missense_Mutation_p.L388Q|SYBU_uc010mcu.3_Missense_Mutation_p.L387Q|SYBU_uc003ynp.4_Missense_Mutation_p.L320Q|SYBU_uc010mcv.3_Missense_Mutation_p.L388Q|SYBU_uc003ynh.4_Missense_Mutation_p.L182Q|SYBU_uc011lhw.2_Missense_Mutation_p.L258Q	NM_001099752	NP_001093225	Q9NX95	SYBU_HUMAN	Homo sapiens syntabulin (syntaxin-interacting) (SYBU), transcript variant 5, mRNA.	388	Sufficient for interaction with KIF5B.|Sufficient for interaction with STX1A.					Golgi membrane|cytoplasmic membrane-bounded vesicle|cytoskeleton|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						GTCTAGGCACAGTTCGTCCCT	0.483000														158			7		0	0	1	0	0
ACTR8	93973	broad.mit.edu	37	3	53914090	53914090	+	Missense_Mutation	SNP	G	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr3:53914090G>T	uc003dhd.3	-	1	271	c.170C>A	c.(169-171)aCt>aAt	p.T57N	ACTR8_uc003dhb.3_5'Flank|ACTR8_uc003dhc.3_5'UTR	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	Homo sapiens ARP8 actin-related protein 8 homolog (yeast) (ACTR8), mRNA.	57					DNA recombination|DNA repair|cell division|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		AATCCTTAAAGTTGTTGAACC	0.428000														98			74		1.42954e-44	1.52484e-44	1	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136544	40136544	+	Silent	SNP	C	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr11:40136544C>G	uc021qgf.1	-	0	1299	c.1299G>C	c.(1297-1299)ggG>ggC	p.G433G	LRRC4C_uc001mxc.1_Silent_p.G429G|LRRC4C_uc001mxd.1_Silent_p.G429G|LRRC4C_uc001mxa.1_Silent_p.G433G|LRRC4C_uc001mxb.1_Silent_p.G429G	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	Homo sapiens leucine rich repeat containing 4C (LRRC4C), mRNA.	433	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				CAGTAGTATTCCCAACGGAAT	0.443000														149			6		0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122406016	122406016	+	Silent	SNP	C	T	T			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr12:122406016C>T	uc009zxk.3	+	16	2871	c.2712C>T	c.(2710-2712)tgC>tgT	p.C904C	WDR66_uc021rfh.1_Silent_p.C904C	NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	Homo sapiens WD repeat domain 66 (WDR66), transcript variant 1, mRNA.	904							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		ATGATGGCTGCTACGCCTTCA	0.537000														48			28		0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110833715	110833715	+	Missense_Mutation	SNP	T	C	C			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr13:110833715T>C	uc001vqw.4	-	28	2239	c.2117A>G	c.(2116-2118)gAc>gGc	p.D706G		NM_001845	NP_001836	P02462	CO4A1_HUMAN	Homo sapiens collagen, type IV, alpha 1 (COL4A1), mRNA.	706	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TGGCCCCATGTCTCCAGGTAA	0.493000														81			4		0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31848534	31848534	+	Missense_Mutation	SNP	C	A	A			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr6:31848534C>A	uc003nxz.1	-	26	3378	c.3368G>T	c.(3367-3369)cGg>cTg	p.R1123L	EHMT2_uc003nxx.1_Missense_Mutation_p.R321L|EHMT2_uc003nxy.1_Missense_Mutation_p.R921L|EHMT2_uc011don.1_Missense_Mutation_p.R1146L|EHMT2_uc003nya.1_Missense_Mutation_p.R1089L|SLC44A4_uc010jti.3_5'Flank|SLC44A4_uc011dom.2_5'Flank	NM_006709	NP_006700	Q96KQ7	EHMT2_HUMAN	Homo sapiens euchromatic histone-lysine N-methyltransferase 2 (EHMT2), transcript variant NG36/G9a, mRNA.	1123	SET.				DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						CATGAAGACCCGGACGGGAAT	0.567000														137			10		1.08611e-07	1.08611e-07	1	1	0
RASA1	5921	broad.mit.edu	37	5	86564705	86564706	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr5:86564705_86564706insG	uc003kiw.3	+	0	636_637	c.437_438insG	c.(436-438)ttgfs	p.L146fs	RASA1_uc010jav.3_Non-coding_Transcript|RASA1_uc003kix.3_5'Flank|RASA1_uc011ctv.2_5'Flank|RASA1_uc011ctw.2_5'Flank|RASA1_uc010jaw.3_5'Flank	NM_002890	NP_002881	P20936	RASA1_HUMAN	Homo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1, mRNA.	146					cytokinesis|embryo development|intracellular signal transduction|negative regulation of Ras protein signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|regulation of RNA metabolic process|regulation of actin filament polymerization|regulation of cell shape|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	GTPase binding|Ras GTPase activator activity|glycoprotein binding|potassium channel inhibitor activity|receptor binding	p.L146S(2)		NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		CTGCCCCCTTTGGGGGCGGGCC	0.624													---	64	---	---	9	---					
SENP6	26054	broad.mit.edu	37	6	76386858	76386858	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr6:76386858delT	uc003pid.4	+	13	2353	c.1734delT	c.(1732-1734)aatfs	p.N578fs	SENP6_uc003pie.4_Frame_Shift_Del_p.N571fs|SENP6_uc010kbf.3_Non-coding_Transcript|SENP6_uc003pic.2_Frame_Shift_Del_p.N571fs|SENP6_uc003pif.1_Frame_Shift_Del_p.N469fs	NM_015571	NP_056386	Q9GZR1	SENP6_HUMAN	Homo sapiens SUMO1/sentrin specific peptidase 6 (SENP6), transcript variant 1, mRNA.	578					proteolysis	cytoplasm|nucleus	cysteine-type peptidase activity			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(105;0.189)				ACATCTCCAATTTTTTTGCGA	0.328													---	247	---	---	10	---					
THSD1P1	374500	broad.mit.edu	37	13	52793775	52793776	+	RNA	INS	-	A	A			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr13:52793775_52793776insA	uc001vgn.3	-	6		c.3541_3542insT			THSD1P1_uc001vgm.1_Intron					Homo sapiens mRNA; cDNA DKFZp434F1622 (from clone DKFZp434F1622).																		CCTAAGAATAGAAAAAAAAATT	0.292													---	4	---	---	2	---					
BORA	79866	broad.mit.edu	37	13	73320117	73320117	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr13:73320117delA	uc010aen.1	+	8	1146	c.999delA	c.(997-999)gcafs	p.A333fs	BORA_uc010thq.1_Frame_Shift_Del_p.A33fs|BORA_uc001viv.1_Frame_Shift_Del_p.A258fs|BORA_uc010thr.1_Frame_Shift_Del_p.A188fs	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	Homo sapiens bora, aurora kinase A activator (BORA), mRNA.	258					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding										AGGCTAGTGCAAAAAAATACA	0.383													---	162	---	---	7	---					
SARS2	54938	broad.mit.edu	37	19	39440795	39440795	+	Frame_Shift_Del	DEL	C	-	-			TCGA-KL-8344-01A-11D-2310-10	TCGA-KL-8344-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3ace181a-23bd-424e-a87e-e0c01a2a2cb8	d0764fec-581b-4bd3-afe8-adcdf685562a	g.chr19:39440795delC	uc002okf.1	-	1	297	c.192delG	c.(190-192)gggfs	p.G64fs	SARS2_uc002okg.1_Frame_Shift_Del_p.G55fs|SARS2_uc010xuq.1_5'Flank	NM_148169	NP_680474	Q9NP81	SYSM_HUMAN	Homo sapiens F-box protein 17 (FBXO17), transcript variant 1, mRNA.	0					seryl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|serine-tRNA ligase activity	p.C64Y(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(60;2.74e-06)|all_epithelial(25;4.36e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			ACACAGTGGGCCCGTCCACTA	0.711													---	4	---	---	2	---					
