Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NEDD9	4739	broad.mit.edu	37	6	11185614	11185614	+	Silent	SNP	C	T	T			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr6:11185614C>T	uc003mzv.2	-	6	2453	c.2286G>A	c.(2284-2286)acG>acA	p.T762T	NEDD9_uc010joz.2_Silent_p.T762T|NEDD9_uc003mzw.3_Silent_p.T616T	NM_006403	NP_006394	Q14511	CASL_HUMAN	Homo sapiens neural precursor cell expressed, developmentally down-regulated 9 (NEDD9), transcript variant 1, mRNA.	762					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	Golgi apparatus|cell cortex|focal adhesion|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCCGTGTCAGCGTGTCTCCAA	0.537000														69			6		0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157805633	157805633	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr1:157805633G>A	uc001frk.4	-	2	511	c.368C>T	c.(367-369)tCg>tTg	p.S123L		NM_005894	NP_005885	O43866	CD5L_HUMAN	Homo sapiens CD5 molecule-like (CD5L), mRNA.	123	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACTCTCACACGATGCCCCAGC	0.502000														73			5		0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100346036	100346036	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr7:100346036G>A	uc003uwj.3	+	10	1357	c.1192G>A	c.(1192-1194)Gga>Aga	p.G398R	ZAN_uc003uwk.3_Missense_Mutation_p.G398R|ZAN_uc003uwl.3_Non-coding_Transcript|ZAN_uc010lhh.3_Non-coding_Transcript|ZAN_uc010lhi.3_Non-coding_Transcript	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	Homo sapiens zonadhesin (ZAN), transcript variant 3, mRNA.	398	MAM 3.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTGGGCCCTCGGACATAAAAA	0.567000														55			14		0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49084509	49084509	+	Silent	SNP	G	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chrX:49084509G>A	uc004dnb.3	-	7	1169	c.1107C>T	c.(1105-1107)ggC>ggT	p.G369G	CACNA1F_uc010nip.3_Silent_p.G369G	NM_005183	NP_005174	O60840	CAC1F_HUMAN	Homo sapiens calcium channel, voltage-dependent, L type, alpha 1F subunit (CACNA1F), mRNA.	369			G -> D (in CSNB2A).		axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	CACTCAGGACGCCAAGCACAA	0.552000														6			81		0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412335	105412335	+	Silent	SNP	C	T	T			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr14:105412335C>T	uc010axc.1	-	6	9573	c.9453G>A	c.(9451-9453)ccG>ccA	p.P3151P	AHNAK2_uc021seo.1_Intron|AHNAK2_uc001ypx.2_Silent_p.P3051P	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	Homo sapiens AHNAK nucleoprotein 2 (AHNAK2), mRNA.	3151						nucleus		p.P3151P(1)		cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCCGAACGACGGCATCTTGA	0.602000														97			3		0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40257897	40257897	+	Silent	SNP	A	G	G			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr15:40257897A>G	uc001zkm.1	+	7	920	c.870A>G	c.(868-870)gaA>gaG	p.E290E	EIF2AK4_uc001zkl.3_Silent_p.E290E|EIF2AK4_uc010bbj.1_Silent_p.E19E	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), mRNA.	290					translation	cytosolic ribosome	ATP binding|aminoacyl-tRNA ligase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GCAGTGATGAACAACTTGGAA	0.418000														88			4		0	0	1	0	0
MLL3	58508	broad.mit.edu	37	7	151917680	151917680	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr7:151917680C>T	uc003wla.3	-	22	3859	c.3640G>A	c.(3640-3642)Gtg>Atg	p.V1214M	MLL3_uc003wkz.3_Missense_Mutation_p.V275M	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), mRNA.	1214					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding	p.S1213S(1)		NS(6)|biliary_tract(9)|breast(24)|central_nervous_system(18)|cervix(6)|endometrium(31)|haematopoietic_and_lymphoid_tissue(1)|kidney(26)|large_intestine(52)|liver(1)|lung(102)|ovary(10)|pancreas(17)|prostate(15)|skin(20)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(8)|urinary_tract(15)	365	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGGACGGCCACGCTATTCTGA	0.393000			N		medulloblastoma									207			4		0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23521146	23521146	+	Silent	SNP	G	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr5:23521146G>A	uc003jgo.3	+	5	548	c.366G>A	c.(364-366)gcG>gcA	p.A122A		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	Homo sapiens PR domain containing 9 (PRDM9), mRNA.	122					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding	p.A122A(2)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						TGCCCAAGGCGTCATTCAGTA	0.398000										HNSCC(3;0.000094)				7			52		0	0	1	0	0
FLNB	2317	broad.mit.edu	37	3	58067357	58067357	+	Splice_Site	SNP	T	C	C			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr3:58067357T>C	uc003djj.2	+	4	805	c.640_splice	c.e4-1	p.V214_splice	FLNB_uc010hne.2_Splice_Site_p.V214_splice|FLNB_uc003djk.2_Splice_Site_p.V214_splice|FLNB_uc010hnf.2_Splice_Site_p.V214_splice|FLNB_uc003djl.2_Splice_Site_p.V45_splice|FLNB_uc003djm.2_Splice_Site_p.V45_splice	NM_001457	NP_001448	O75369	FLNB_HUMAN	Homo sapiens filamin B, beta (FLNB), transcript variant 2, mRNA.	214	Actin-binding.|CH 2.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TTATCCTAGGTCATCACTCCT	0.458000														91			4		0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777867	18777867	+	Missense_Mutation	SNP	T	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr9:18777867T>A	uc003zne.4	+	18	3792	c.3640T>A	c.(3640-3642)Tgg>Agg	p.W1214R		NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	Homo sapiens ADAMTS-like 1 (ADAMTSL1), transcript variant 4, mRNA.	1214	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding	p.W1214R(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TACCATCAGCTGGGCCAGGAA	0.612000														119			13		0	0	1	0	0
CAPRIN1	4076	broad.mit.edu	37	11	34074126	34074126	+	Silent	SNP	C	T	T			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr11:34074126C>T	uc001mvh.1	+	1	348	c.159C>T	c.(157-159)gcC>gcT	p.A53A	CAPRIN1_uc001mvg.3_Silent_p.A53A|CAPRIN1_uc001mvi.2_Silent_p.A53A|CAPRIN1_uc001mvj.1_5'Flank	NM_005898	NP_005889	Q14444	CAPR1_HUMAN	Homo sapiens cell cycle associated protein 1 (CAPRIN1), transcript variant 1, mRNA.	53					negative regulation of translation|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis	cytoplasmic mRNA processing body|cytosol|dendrite|integral to plasma membrane|stress granule	RNA binding|protein binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)	18		Acute lymphoblastic leukemia(5;0.00045)|all_hematologic(20;0.0016)				AGACCGAGGCCATGAAGCAGA	0.692000														51			3		0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96953605	96953605	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr2:96953605G>A	uc002svu.3	-	24	3493	c.3361C>T	c.(3361-3363)Cgc>Tgc	p.R1121C	SNRNP200_uc010yuj.2_5'Flank|SNRNP200_uc002svv.1_5'Flank	NM_014014	NP_054733	O75643	U520_HUMAN	Homo sapiens small nuclear ribonucleoprotein 200kDa (U5) (SNRNP200), mRNA.	1121	SEC63 1.					U5 snRNP|catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CCTTACATGCGTTTGTCGATC	0.547000														93			3		0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285540	48285540	+	Missense_Mutation	SNP	T	C	C	rs144193033		TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr11:48285540T>C	uc010rht.2	+	0	128	c.128T>C	c.(127-129)aTt>aCt	p.I43T		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily X, member 1 (OR4X1), mRNA.	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						AATGGCCTCATTGTGGTGACC	0.478000														152			35		0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41354576	41354576	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr19:41354576C>T	uc002opl.4	-	2	457	c.436G>A	c.(436-438)Gag>Aag	p.E146K	CYP2A6_uc010ehe.1_5'UTR|CYP2A6_uc010ehf.1_Non-coding_Transcript	NM_000762	NP_000753	P11509	CP2A6_HUMAN	Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6), mRNA.	146					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	ATGCGCTCCTCGATGCCTCGC	0.692000														80			5		0	0	1	0	0
MPZL3	196264	broad.mit.edu	37	11	118111082	118111082	+	Silent	SNP	G	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr11:118111082G>A	uc001psm.3	-	1	86	c.84C>T	c.(82-84)atC>atT	p.I28I	MPZL3_uc010rxy.2_Intron|MPZL3_uc010rxz.2_Non-coding_Transcript|MPZL3_uc009yzy.3_Intron	NM_198275	NP_938016	Q6UWV2	MPZL3_HUMAN	Homo sapiens myelin protein zero-like 3 (MPZL3), mRNA.	28					cell adhesion	integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		AGGAAAAGACGATATAAACAC	0.388000														66			9		0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23393288	23393288	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr14:23393288T>C	uc001whm.1	-	11	1395	c.1304A>G	c.(1303-1305)gAg>gGg	p.E435G	PRMT5_uc001whl.1_Missense_Mutation_p.E418G|PRMT5_uc010tnf.1_Missense_Mutation_p.E329G|PRMT5_uc010tnh.1_Missense_Mutation_p.E391G|PRMT5_uc010tng.1_Missense_Mutation_p.E374G|PRMT5_uc001whn.1_Missense_Mutation_p.E264G	NM_006109	NP_006100	O14744	ANM5_HUMAN	Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 1, mRNA.	435					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		GCCCAGAAGCTCACTGACAAT	0.532000														74			4		0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20094117	20094117	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr22:20094117A>G	uc002zri.3	+	10	2321	c.1892A>G	c.(1891-1893)aAc>aGc	p.N631S	DGCR8_uc010grz.3_Missense_Mutation_p.N598S|DGCR8_uc002zrj.3_Missense_Mutation_p.N274S	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	Homo sapiens DiGeorge syndrome critical region gene 8 (DGCR8), transcript variant 1, mRNA.	631	DRBM 2.|Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					TCTTAAAGAAACCATGGGATG	0.532000														164			5		0	0	1	0	0
MORN1	79906	broad.mit.edu	37	1	2268198	2268198	+	Silent	SNP	C	T	T			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr1:2268198C>T	uc001ajb.1	-	10	1149	c.1128G>A	c.(1126-1128)ccG>ccA	p.P376P	MORN1_uc009vld.3_Silent_p.P352P	NM_024848	NP_079124	Q5T089	MORN1_HUMAN	Homo sapiens MORN repeat containing 1 (MORN1), mRNA.	376										breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(1)|ovary(2)	9	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GGTACCCAGGCGGGGGCGGCC	0.682000														28			13		0	0	1	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204379294	204379294	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr1:204379294A>G	uc001hav.4	-	0	1651	c.1246T>C	c.(1246-1248)Tct>Cct	p.S416P		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 15B (PPP1R15B), mRNA.	416					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			GGTCTGGCAGAAATGGGAAGG	0.458000														37			3		0	0	1	0	0
FSD2	123722	broad.mit.edu	37	15	83451563	83451563	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr15:83451563T>C	uc002bjd.2	-	3	1117	c.950A>G	c.(949-951)aAg>aGg	p.K317R	FSD2_uc010uol.1_Missense_Mutation_p.K317R|FSD2_uc010uom.1_Missense_Mutation_p.K317R	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	Homo sapiens fibronectin type III and SPRY domain containing 2 (FSD2), mRNA.	317										breast(2)|central_nervous_system(1)|large_intestine(5)|lung(10)	18						GAAATCCACCTTCTCCTCGTG	0.378000														304			6		0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28848967	28848967	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr7:28848967A>G	uc003szq.3	+	8	1580	c.1190A>G	c.(1189-1191)aAg>aGg	p.K397R	CREB5_uc003szo.3_Missense_Mutation_p.K364R|CREB5_uc003szr.3_Missense_Mutation_p.K390R|CREB5_uc003szs.3_Missense_Mutation_p.K258R	NM_182898	NP_878902	Q02930	CREB5_HUMAN	Homo sapiens cAMP responsive element binding protein 5 (CREB5), transcript variant 1, mRNA.	397					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						CAGAAGAGGAAGGTCTGGGTG	0.592000														113			4		0	0	1	0	0
OR4C12	283093	broad.mit.edu	37	11	50004015	50004015	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr11:50004015G>A	uc010ria.2	-	0	57	c.23C>T	c.(22-24)aCt>aTt	p.T8I		NM_001005270	NP_001005270	Q96R67	OR4CC_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily C, member 12 (OR4C12), mRNA.	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						AATGAATTCAGTCACATTCTT	0.338000														36			35		0	0	1	0	0
SNAPIN	23557	broad.mit.edu	37	1	153631301	153631301	+	Frame_Shift_Del	DEL	G	-	-	rs35903030		TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr1:153631301delG	uc001fcq.3	+	0	157	c.82delG	c.(82-84)gggfs	p.G28fs		NM_012437	NP_036569	O95295	SNAPN_HUMAN	Homo sapiens SNAP-associated protein (SNAPIN), mRNA.	28					intracellular protein transport|synaptic vesicle exocytosis	BLOC-1 complex|cell junction|perinuclear region of cytoplasm|synaptic vesicle membrane|synaptosome	SNARE binding			lung(3)	3	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTTCGCCGAAGGGCTGCTGGA	0.692													---	37	---	---	19	---					
ANO10	55129	broad.mit.edu	37	3	43607195	43607195	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr3:43607195delA	uc003cmv.3	-	7	1414	c.1243delT	c.(1243-1245)tcafs	p.S415fs	ANO10_uc011azs.2_Frame_Shift_Del_p.S415fs|ANO10_uc003cmw.3_Frame_Shift_Del_p.S349fs|ANO10_uc010hil.3_Frame_Shift_Del_p.S225fs|ANO10_uc011azt.2_Frame_Shift_Del_p.S304fs	NM_018075	NP_060545	Q9NW15	ANO10_HUMAN	Homo sapiens anoctamin 10 (ANO10), transcript variant 1, mRNA.	415					cell death	chloride channel complex	chloride channel activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(9)|ovary(3)|prostate(3)|skin(3)	29						TAGAAGAGTGAGGCAAAGCAA	0.333													---	289	---	---	7	---					
KCNH2	3757	broad.mit.edu	37	7	150642468	150642469	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr7:150642468_150642469insG	uc003wic.3	-	14	3865_3866	c.3464_3465insC	c.(3463-3465)tcgfs	p.S1155fs	KCNH2_uc003wib.3_Frame_Shift_Ins_p.S815fs|KCNH2_uc011kux.2_Frame_Shift_Ins_p.S1059fs	NM_000238	NP_000229	Q12809	KCNH2_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2), transcript variant 1, mRNA.	1155					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TGCCCGGGTCCGAGCCGTGTCT	0.718													---	153	---	---	8	---					
CAMSAP1	157922	broad.mit.edu	37	9	138715800	138715800	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr9:138715800delT	uc004cgr.4	-	9	1396	c.1396delA	c.(1396-1398)accfs	p.T466fs	CAMSAP1_uc004cgq.4_Frame_Shift_Del_p.T356fs|CAMSAP1_uc010nbg.3_Frame_Shift_Del_p.T188fs	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	Homo sapiens calmodulin regulated spectrin-associated protein 1 (CAMSAP1), mRNA.	466						cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		ACTCACCTGGTTTTTTTTTCT	0.463													---	97	---	---	8	---					
TPTE2P3	220115	broad.mit.edu	37	13	53157247	53157247	+	RNA	DEL	A	-	-			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr13:53157247delA	uc001vgw.3	+	21		c.2185delA								Homo sapiens transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3 (TPTE2P3), non-coding RNA.																		CATGACACTGAAACAGACAGG	0.373													---	4	---	---	2	---					
ARID4A	5926	broad.mit.edu	37	14	58831996	58831997	+	Frame_Shift_Del	DEL	AG	-	-			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr14:58831996_58831997delAG	uc001xdp.3	+	19	3443_3444	c.3189_3190delAG	c.(3187-3192)caagagfs	p.Q1063fs	ARID4A_uc001xdo.3_Frame_Shift_Del_p.Q1063fs|ARID4A_uc001xdq.3_Frame_Shift_Del_p.Q1063fs|ARID4A_uc010apg.1_Frame_Shift_Del_p.Q741fs	NM_002892	NP_002883	P29374	ARI4A_HUMAN	Homo sapiens AT rich interactive domain 4A (RBP1-like) (ARID4A), transcript variant 1, mRNA.	1063					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TAATTGTACAAGAGAGAGAGAG	0.381													---	75	---	---	7	---					
CCDC144C	348254	broad.mit.edu	37	17	20224506	20224507	+	RNA	INS	-	T	T			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr17:20224506_20224507insT	uc010cqy.1	+	0		c.20_21insT								Homo sapiens coiled-coil domain containing 144C (CCDC144C), non-coding RNA.											breast(2)|endometrium(1)|kidney(4)|lung(4)|prostate(1)|urinary_tract(1)	13						GCAGTGGTCGCTTGGCTTGGCG	0.599													---	4	---	---	2	---					
FCGBP	8857	broad.mit.edu	37	19	40380652	40380652	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr19:40380652delA	uc002omp.4	-	22	10671	c.10663delT	c.(10663-10665)tgcfs	p.C3555fs		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Homo sapiens Fc fragment of IgG binding protein (FCGBP), mRNA.	3555	Cys-rich.|TIL 8.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGGCTCGGGCAGCTCCCAGGA	0.637													---	4	---	---	3	---					
SON	6651	broad.mit.edu	37	21	34927419	34927420	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KM-8442-01A-11D-2310-10	TCGA-KM-8442-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9fb73d89-f7c4-47b2-810b-3ce37cd8a3c9	6fc570c7-dca7-4892-bbf8-94afd186a057	g.chr21:34927419_34927420insC	uc002yse.1	+	2	5931_5932	c.5882_5883insC	c.(5881-5883)agcfs	p.S1961fs	SON_uc002ysb.1_Frame_Shift_Ins_p.S1961fs|SON_uc002ysc.3_Frame_Shift_Ins_p.S1961fs|SON_uc002ysd.3_Frame_Shift_Ins_p.S952fs|SON_uc002ysf.1_Intron|SON_uc002ysg.3_Frame_Shift_Ins_p.S952fs	NM_138927	NP_620305	P18583	SON_HUMAN	Homo sapiens SON DNA binding protein (SON), transcript variant f, mRNA.	1961	2 X 19 AA repeats of P-S-R-R-R-R-S-R-S-V- V-R-R-R-S-F-S-I-S.|7 X 7 AA repeats of P-S-R-R-S-R-[TS].				RNA splicing|anti-apoptosis|cytokinesis|mRNA processing|regulation of RNA splicing|regulation of cell cycle|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						cgcacccccagccgccgcagcc	0.713													---	4	---	---	2	---					
