Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM69C	125704	broad.mit.edu	37	18	72114400	72114400	+	Missense_Mutation	SNP	G	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr18:72114400G>T	uc002llk.3	-	1	326	c.317C>A	c.(316-318)gCc>gAc	p.A106D		NM_001044369	NP_001037834	Q0P6D2	FA69C_HUMAN	Homo sapiens family with sequence similarity 69, member C (FAM69C), mRNA.	106						endoplasmic reticulum membrane|integral to membrane				breast(1)|large_intestine(2)|ovary(2)	5						GCGCCAGTCGGCCTGCAGCAC	0.677000														64			6		2.0095e-06	2.04191e-06	1	1	0
GRM1	2911	broad.mit.edu	37	6	146720023	146720023	+	Silent	SNP	G	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr6:146720023G>T	uc010khw.1	+	7	2318	c.1848G>T	c.(1846-1848)ctG>ctT	p.L616L	GRM1_uc010khv.1_Silent_p.L616L|GRM1_uc003qll.2_Silent_p.L616L|GRM1_uc011edz.1_Silent_p.L616L|GRM1_uc011eea.1_Silent_p.L616L	NM_000838	NP_000829	Q13255	GRM1_HUMAN	Homo sapiens glutamate receptor, metabotropic 1 (GRM1), transcript variant 1, mRNA.	616					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCTTTGTACTGTACCGGGACA	0.483000														22			105		2.2063e-47	2.35588e-47	1	1	0
PCDHAC2	56134	broad.mit.edu	37	5	140223107	140223107	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr5:140223107C>T	uc003lhs.2	+	0	2201	c.2201C>T	c.(2200-2202)gCg>gTg	p.A734V	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhr.1_Missense_Mutation_p.A734V	NM_018911	NP_061734	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 8 (PCDHA8), transcript variant 1, mRNA.	750					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGTGCCGGGCGGGCAAGCCC	0.662000														181			4		0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913571	77913571	+	Missense_Mutation	SNP	G	A	A	rs144237768		TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chrX:77913571G>A	uc022bzi.1	-	0	347	c.347C>T	c.(346-348)gCg>gTg	p.A116V	ZCCHC5_uc004edc.1_Missense_Mutation_p.A116V	NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	Homo sapiens zinc finger, CCHC domain containing 5 (ZCCHC5), mRNA.	116	Pro-rich.						nucleic acid binding|zinc ion binding	p.A116A(2)|p.A116V(2)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TGCTGGAGGCGCCAGGGACTC	0.627000														55			4		0	0	1	0	0
CCT6P3	643180	broad.mit.edu	37	7	64530103	64530103	+	RNA	SNP	G	A	A	rs137873032	by1000genomes	TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr7:64530103G>A	uc003ttt.1	+	6		c.929G>A			CCT6P3_uc010kzt.1_Non-coding_Transcript					Homo sapiens chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3 (CCT6P3), non-coding RNA.																		TGACTGCTTGGGACATGCAGG	0.388000														49			3		0	0	1	0	0
ZNF701	55762	broad.mit.edu	37	19	53086657	53086657	+	Nonsense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr19:53086657C>T	uc010ydn.2	+	4	1606	c.1543C>T	c.(1543-1545)Cga>Tga	p.R515*	ZNF701_uc002pzs.2_Nonsense_Mutation_p.R449*|ZNF701_uc021uyw.1_Nonsense_Mutation_p.R515*	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	Homo sapiens zinc finger protein 701 (ZNF701), transcript variant 2, mRNA.	449					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R449*(1)		endometrium(5)|kidney(1)|large_intestine(2)|lung(6)	14				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		GGTTTTTAATCGAAAATCAAA	0.358000														232			6		0	0	1	0	0
ATP9B	374868	broad.mit.edu	37	18	77090010	77090010	+	Splice_Site	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr18:77090010A>G	uc002lmx.3	+	17	1950	c.1936_splice	c.e17-2	p.D646_splice	ATP9B_uc002lmw.1_Splice_Site_p.D646_splice|ATP9B_uc002lmz.1_Splice_Site_p.D340_splice	NM_198531	NP_940933	O43861	ATP9B_HUMAN	Homo sapiens ATPase, class II, type 9B (ATP9B), mRNA.	646					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|aminophospholipid transporter activity|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		GTTCTTTGATAGGATGAATCC	0.423000														194			5		0	0	1	0	0
PMPCB	9512	broad.mit.edu	37	7	102944340	102944340	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr7:102944340A>G	uc003vbk.1	+	4	543	c.509A>G	c.(508-510)gAg>gGg	p.E170G	PMPCB_uc010liu.1_Missense_Mutation_p.E170G|PMPCB_uc003vbl.3_Missense_Mutation_p.E170G|PMPCB_uc011kll.1_Missense_Mutation_p.E65G|PMPCB_uc011klm.1_Missense_Mutation_p.E45G	NM_004279	NP_004270	O75439	MPPB_HUMAN	Homo sapiens peptidase (mitochondrial processing) beta (PMPCB), nuclear gene encoding mitochondrial protein, mRNA.	170					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(9)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GGAGAAGCAGAGATTGAACGT	0.348000														122			4		0	0	1	0	0
OR6B3	150681	broad.mit.edu	37	2	240984793	240984793	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr2:240984793C>T	uc010zoe.2	-	0	697	c.697G>A	c.(697-699)Ggc>Agc	p.G233S	PRR21_uc010zod.2_5'Flank	NM_173351	NP_775486	Q8NGW1	OR6B3_HUMAN	Homo sapiens olfactory receptor, family 6, subfamily B, member 3 (OR6B3), mRNA.	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(10)|lung(4)|ovary(2)|prostate(1)	18		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;1.05e-29)|all cancers(36;3.52e-28)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		CTCCAGCAGCCGGTGGCCGAG	0.577000														124			4		0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131922101	131922101	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr8:131922101G>A	uc003ytd.4	-	5	1749	c.1493C>T	c.(1492-1494)tCa>tTa	p.S498L	ADCY8_uc010mds.3_Missense_Mutation_p.S498L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	Homo sapiens adenylate cyclase 8 (brain) (ADCY8), mRNA.	498					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding	p.R497L(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TTTTGTCCTTGACCGCACATA	0.448000										HNSCC(32;0.087)				57			25		0	0	1	0	0
ZNF181	339318	broad.mit.edu	37	19	35232200	35232200	+	Missense_Mutation	SNP	T	G	G	rs143797666		TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr19:35232200T>G	uc002nvu.3	+	3	1377	c.914T>G	c.(913-915)gTc>gGc	p.V305G	ZNF181_uc010xsb.1_Missense_Mutation_p.V304G|ZNF181_uc010xsc.1_Missense_Mutation_p.V240G	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	Homo sapiens zinc finger protein 181 (ZNF181), transcript variant 1, mRNA.	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.V241G(4)		endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(1)	22	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			TTTAGCCATGTCTCATCACTT	0.413000														86			4		0	0	1	0	0
SIRT3	23410	broad.mit.edu	37	11	224195	224195	+	Silent	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr11:224195G>A	uc001lok.4	-	4	886	c.852C>T	c.(850-852)acC>acT	p.T284T	SIRT3_uc001loj.4_Silent_p.T142T|SIRT3_uc010qvm.2_Silent_p.T220T|SIRT3_uc010qvn.2_Silent_p.T203T|SIRT3_uc010qvo.2_Silent_p.T284T|SIRT3_uc010qvp.2_Intron|SIRT3_uc010qvq.2_Silent_p.T142T|SIRT3_uc009ybt.1_Non-coding_Transcript	NM_012239	NP_001017524	Q9NTG7	SIRT3_HUMAN	Homo sapiens sirtuin 3 (SIRT3), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	284	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	NAD+ ADP-ribosyltransferase activity|NAD+ binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|protein binding|zinc ion binding			endometrium(1)|lung(5)|urinary_tract(1)	7		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		TCACAACGCCGGTGCAGACCG	0.572000														151			4		0	0	1	0	0
ZNF280B	140883	broad.mit.edu	37	22	22842485	22842485	+	Silent	SNP	C	T	T	rs141102079		TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr22:22842485C>T	uc002zwc.1	-	3	2015	c.1239G>A	c.(1237-1239)tcG>tcA	p.S413S	abParts_uc021wml.1_Intron|abParts_uc021wmm.1_Intron|ZNF280B_uc021wmn.1_Silent_p.S413S	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	Homo sapiens zinc finger protein 280B (ZNF280B), mRNA.	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		CAGCAAAGACCGACGATCTAT	0.403000														119			88		0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109577282	109577282	+	Silent	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr12:109577282G>A	uc001tob.3	+	1	191	c.72G>A	c.(70-72)ggG>ggA	p.G24G	ACACB_uc001toc.3_Silent_p.G24G	NM_001093	NP_001084	O00763	ACACB_HUMAN	Homo sapiens acetyl-CoA carboxylase beta (ACACB), mRNA.	24					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	Golgi apparatus|cytosol|endomembrane system|membrane	ATP binding|acetyl-CoA carboxylase activity|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AAATCTGGGGGAAAATGACGG	0.463000														130			7		0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141335867	141335867	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr5:141335867A>G	uc003llx.3	-	0	2761	c.1550T>C	c.(1549-1551)gTc>gCc	p.V517A		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	Homo sapiens protocadherin 12 (PCDH12), mRNA.	517	Cadherin 5.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAGCAGTGACCTCTCCTGT	0.517000														130			5		0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180053237	180053237	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr5:180053237G>A	uc003mlz.4	-	8	1211	c.1132C>T	c.(1132-1134)Cgc>Tgc	p.R378C	FLT4_uc003mma.4_Missense_Mutation_p.R378C|FLT4_uc003mmb.1_5'UTR|FLT4_uc011dgy.2_Missense_Mutation_p.R378C	NM_182925	NP_891555	P35916	VGFR3_HUMAN	Homo sapiens fms-related tyrosine kinase 4 (FLT4), transcript variant 1, mRNA.	378	Ig-like C2-type 4.		R -> C (in a renal clear cell carcinoma sample; somatic mutation).		positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity	p.R378C(2)|p.G377R(1)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GGACTGTGGCGCCCGGACAGT	0.647000														85			7		0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131750367	131750367	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr9:131750367A>G	uc004bws.1	+	23	2457	c.2435A>G	c.(2434-2436)aAg>aGg	p.K812R	NUP188_uc004bwu.3_Missense_Mutation_p.K155R	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	Homo sapiens nucleoporin 188kDa (NUP188), mRNA.	812					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						CTGCTGATCAAGACAGTGAAA	0.502000														107			4		0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683388	140683388	+	Silent	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr5:140683388C>T	uc003ljf.3	-	0	225	c.45G>A	c.(43-45)gcG>gcA	p.A15A		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	Homo sapiens solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 (SLC25A2), nuclear gene encoding mitochondrial protein, mRNA.	15					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity	p.A15V(1)		breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	CTGCGGCCCCCGCTGTGAGGT	0.607000														116			4		0	0	1	0	0
ABP1	26	broad.mit.edu	37	7	150555109	150555109	+	Silent	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr7:150555109C>T	uc003why.1	+	2	5769	c.1551C>T	c.(1549-1551)cgC>cgT	p.R517R	ABP1_uc003whz.1_Silent_p.R517R|ABP1_uc003wia.1_Silent_p.R517R	NM_001091	NP_001082	P19801	ABP1_HUMAN	Homo sapiens amiloride binding protein 1 (amine oxidase (copper-containing)) (ABP1), mRNA.	517					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding	p.R517S(1)		NS(1)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(3)|prostate(2)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	TGCACTACCGCGTAGACCTGG	0.567000														12			4		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117887	117887	+	RNA	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chrGL000205.1:117887C>T	uc002kgk.4	+	0		c.1265C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		TCTCAACGAACAAAACTACCA	0.522000														20			3		0	0	1	0	0
PABPC1	26986	broad.mit.edu	37	8	101724606	101724606	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr8:101724606G>A	uc003yjs.1	-	6	1460	c.956C>T	c.(955-957)aCa>aTa	p.T319I	PABPC1_uc011lhc.1_Missense_Mutation_p.T287I|PABPC1_uc011lhd.1_Missense_Mutation_p.T274I|PABPC1_uc003yjt.1_Missense_Mutation_p.T316I|PABPC1_uc003yju.2_Non-coding_Transcript	NM_002568	NP_002559	P11940	PABP1_HUMAN	Homo sapiens poly(A) binding protein, cytoplasmic 1 (PABPC1), mRNA.	319	RRM 4.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity	p.T319I(4)		breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			ACTAGTGATTGTACCAAATGG	0.284000														116			4		0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527628	23527628	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr5:23527628C>T	uc003jgo.3	+	10	2613	c.2431C>T	c.(2431-2433)Cgg>Tgg	p.R811W		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	Homo sapiens PR domain containing 9 (PRDM9), mRNA.	811					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGAGTGTGGGCGGGGCTTTAG	0.572000										HNSCC(3;0.000094)				118			5		0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80327734	80327734	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr4:80327734C>T	uc003hlu.3	-	0	1639	c.1621G>A	c.(1621-1623)Gta>Ata	p.V541I		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	Homo sapiens glycerol kinase 2 (GK2), mRNA.	541					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						ATTAGCATTACCATGCTACTC	0.398000														80			64		0	0	1	0	0
ODF2	4957	broad.mit.edu	37	9	131245156	131245156	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr9:131245156A>G	uc004bvc.3	+	9	1255	c.1169A>G	c.(1168-1170)cAa>cGa	p.Q390R	ODF2_uc011maz.2_Missense_Mutation_p.Q326R|ODF2_uc011mba.2_Non-coding_Transcript|ODF2_uc010myb.3_Missense_Mutation_p.Q302R|ODF2_uc011mbc.2_Missense_Mutation_p.Q245R|ODF2_uc022boj.1_Missense_Mutation_p.Q351R|ODF2_uc004bva.3_Missense_Mutation_p.Q370R|ODF2_uc004bvb.3_Missense_Mutation_p.Q302R|ODF2_uc011mbd.2_Missense_Mutation_p.Q326R|ODF2_uc011mbe.2_Missense_Mutation_p.Q321R|ODF2_uc010myc.3_Missense_Mutation_p.Q269R|ODF2_uc011mbf.2_Missense_Mutation_p.Q307R|ODF2_uc004bvd.4_Missense_Mutation_p.Q326R|ODF2_uc004bve.3_Missense_Mutation_p.Q307R|BC094874_uc004bvg.3_5'Flank	NM_153435	NP_702913	Q5BJF6	ODFP2_HUMAN	Homo sapiens outer dense fiber of sperm tails 2 (ODF2), transcript variant 1, mRNA.	326					G2/M transition of mitotic cell cycle|cell differentiation|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			autonomic_ganglia(1)|breast(7)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	37						CAGGAAATACAATGTGAGAAG	0.522000														42			3		0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12162043	12162043	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr6:12162043G>A	uc003nac.3	+	7	7038	c.6859G>A	c.(6859-6861)Gac>Aac	p.D2287N	HIVEP1_uc011diq.2_Non-coding_Transcript	NM_002114	NP_002105	P15822	ZEP1_HUMAN	Homo sapiens human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1), mRNA.	2287					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGATGAAAACGACACAATTCC	0.512000														56			14		0	0	1	0	0
FAM153B	202134	broad.mit.edu	37	5	175511995	175511995	+	Splice_Site	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr5:175511995A>G	uc003mdk.3	+	1	88	c.31_splice	c.e1+1	p.V11_splice	FAM153B_uc010jjy.1_Intron|FAM153B_uc021yic.1_Intron	NM_001079529	NP_001072997	P0C7A2	F153B_HUMAN	Homo sapiens family with sequence similarity 153, member B (FAM153B), mRNA.	11										endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	16	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		GTTGCCTCGAAGGTATGTATG	0.398000														666			7		0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78749078	78749078	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr9:78749078C>T	uc004akc.2	+	9	1800	c.1262C>T	c.(1261-1263)gCg>gTg	p.A421V	PCSK5_uc004ajy.2_Missense_Mutation_p.A421V|PCSK5_uc004ajz.3_Missense_Mutation_p.A421V|PCSK5_uc004aka.3_Intron	NM_001190482	NP_001177411	Q92824	PCSK5_HUMAN	Homo sapiens proprotein convertase subtilisin/kexin type 5 (PCSK5), transcript variant 1, mRNA.	421	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	Golgi lumen|extracellular space|stored secretory granule	peptide binding|serine-type endopeptidase activity	p.R420L(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						ACTTCCCGTGCGGGACATTTG	0.398000														31			17		0	0	1	0	0
LILRB3	11025	broad.mit.edu	37	19	54803112	54803112	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr19:54803112G>A	uc002qfd.3	-	3	657	c.565C>T	c.(565-567)Cca>Tca	p.P189S	LILRB3_uc002qew.2_Intron|LILRB3_uc010erk.3_Intron	NM_006865	NP_006856	O75022	LIRB3_HUMAN	Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 (LILRA3), transcript variant 1, mRNA.	188	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGCGACTTGGGCTCACGGGG	0.592000														194			4		0	0	1	0	0
TRPC1	7220	broad.mit.edu	37	3	142525034	142525034	+	Missense_Mutation	SNP	G	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr3:142525034G>T	uc003evc.3	+	12	2475	c.2339G>T	c.(2338-2340)gGc>gTc	p.G780V	TRPC1_uc003evb.3_Missense_Mutation_p.G746V	NM_001251845	NP_001238774	P48995	TRPC1_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily C, member 1 (TRPC1), transcript variant 1, mRNA.	780					axon guidance|cytosolic calcium ion homeostasis|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion	cytosol|integral to plasma membrane	protein binding|store-operated calcium channel activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(2)|stomach(3)|urinary_tract(1)	37						GATTTACTTGGCTTTCGGACT	0.338000														233			10		1.04858e-14	1.101e-14	1	1	0
MYH1	4619	broad.mit.edu	37	17	10395792	10395792	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr17:10395792C>T	uc002gmo.3	-	39	5855	c.5761G>A	c.(5761-5763)Gtc>Atc	p.V1921I	AK097500_uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	Homo sapiens myosin, heavy chain 1, skeletal muscle, adult (MYH1), mRNA.	1921						muscle myosin complex|myofibril|myosin filament	ATP binding|actin binding|calmodulin binding|motor activity	p.V1921V(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						AGCTTGTTGACCTGGGACTCA	0.483000														84			7		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117245	117245	+	RNA	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chrGL000205.1:117245C>T	uc002kgk.4	+	0		c.623C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GAGGAATTCGCCCCCAGATCA	0.527000														16			3		0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800335	21800335	+	Missense_Mutation	SNP	C	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr22:21800335C>G	uc002zur.4	+	2	1381	c.1151C>G	c.(1150-1152)cCt>cGt	p.P384R	HIC2_uc002zus.4_Missense_Mutation_p.P384R	NM_015094	NP_055909	Q96JB3	HIC2_HUMAN	Homo sapiens hypermethylated in cancer 2 (HIC2), mRNA.	384					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GGGGCTGGCCCTAGCGGGCCC	0.687000														17			12		0	0	1	0	0
FNIP2	57600	broad.mit.edu	37	4	159780275	159780275	+	Silent	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr4:159780275G>A	uc003iqe.4	+	8	1107	c.924G>A	c.(922-924)agG>agA	p.R308R		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	Homo sapiens folliculin interacting protein 2 (FNIP2), mRNA.	308					DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		TGGTTAGGAGGAAGAAAATTG	0.398000														265			12		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118114	118114	+	RNA	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chrGL000205.1:118114C>T	uc002kgk.4	+	0		c.1492C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		CTCTCACTGCCTGCTACAGCC	0.552000														42			3		0	0	1	0	0
ST3GAL2	6483	broad.mit.edu	37	16	70432188	70432188	+	Silent	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr16:70432188G>A	uc002eyw.2	-	0	2354	c.246C>T	c.(244-246)tcC>tcT	p.S82S	ST3GAL2_uc002eyx.2_Silent_p.S82S	NM_006927	NP_008858	Q16842	SIA4B_HUMAN	Homo sapiens ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (ST3GAL2), mRNA.	82					amino sugar metabolic process	Golgi cisterna membrane|extracellular region|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity	p.S82S(2)		breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	11		Ovarian(137;0.0694)				CAAACCAGTCGGAGGCACCGG	0.627000														62			3		0	0	1	0	0
USP10	9100	broad.mit.edu	37	16	84793019	84793019	+	Missense_Mutation	SNP	C	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr16:84793019C>A	uc010voe.2	+	6	1598	c.1347C>A	c.(1345-1347)ttC>ttA	p.F449L	USP10_uc002fii.3_Missense_Mutation_p.F445L|USP10_uc010vof.2_Missense_Mutation_p.F7L|USP10_uc002fij.3_Intron	NM_005153	NP_005144	Q14694	UBP10_HUMAN	Homo sapiens ubiquitin specific peptidase 10 (USP10), mRNA.	445					DNA damage response, signal transduction by p53 class mediator|DNA repair|protein deubiquitination|ubiquitin-dependent protein catabolic process	early endosome|intermediate filament cytoskeleton|nucleus	cystic fibrosis transmembrane conductance regulator binding|p53 binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(3)|prostate(1)|stomach(1)|urinary_tract(1)	17						TGATGAAGTTCATTCCTCTGT	0.463000														167			23		0.000295444	0.000295444	1	1	0
SFT2D1	113402	broad.mit.edu	37	6	166736357	166736357	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr6:166736357A>G	uc003qux.3	-	6	450	c.428T>C	c.(427-429)aTc>aCc	p.I143T		NM_145169	NP_660152	Q8WV19	SFT2A_HUMAN	Homo sapiens SFT2 domain containing 1 (SFT2D1), mRNA.	143					protein transport|vesicle-mediated transport	integral to membrane				NS(1)|central_nervous_system(1)|large_intestine(3)|upper_aerodigestive_tract(1)	6		Breast(66;0.000148)|Prostate(117;0.109)|Ovarian(120;0.199)		OV - Ovarian serous cystadenocarcinoma(33;2.63e-19)|BRCA - Breast invasive adenocarcinoma(81;4.92e-06)|GBM - Glioblastoma multiforme(31;4.58e-05)		TGCATATGGGATGTACGACAG	0.318000														80			4		0	0	1	0	0
HPS4	89781	broad.mit.edu	37	22	26860415	26860415	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr22:26860415A>G	uc003acl.3	-	10	1840	c.1181T>C	c.(1180-1182)gTt>gCt	p.V394A	HPS4_uc003aci.3_Missense_Mutation_p.V389A|HPS4_uc003acj.3_Missense_Mutation_p.V258A|HPS4_uc003ack.3_Missense_Mutation_p.V185A|HPS4_uc003acn.3_Missense_Mutation_p.V240A|HPS4_uc010gvd.1_Missense_Mutation_p.V412A|HPS4_uc003ach.3_Missense_Mutation_p.V129A	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	Homo sapiens Hermansky-Pudlak syndrome 4 (HPS4), transcript variant 1, mRNA.	394					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						GCCATCTGGAACAGGCACATG	0.552000									Hermansky-Pudlak syndrome					94			4		0	0	1	0	0
TCERG1L	256536	broad.mit.edu	37	10	132932683	132932683	+	Silent	SNP	T	C	C			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr10:132932683T>C	uc001lkp.3	-	7	1304	c.1218A>G	c.(1216-1218)gaA>gaG	p.E406E	TCERG1L_uc009yax.1_Non-coding_Transcript	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	Homo sapiens transcription elongation regulator 1-like (TCERG1L), mRNA.	406										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		CCCTGTTGTCTTCAGAACTGG	0.507000														81			4		0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52613683	52613683	+	Silent	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr15:52613683A>G	uc002aby.2	-	36	4993	c.4749T>C	c.(4747-4749)tcT>tcC	p.S1583S	MYO5A_uc002abx.3_Silent_p.S1556S|MYO5A_uc010ugd.1_Silent_p.S305S	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	Homo sapiens myosin VA (heavy chain 12, myoxin) (MYO5A), transcript variant 1, mRNA.	1583	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	ATP binding|actin binding|calmodulin binding|microfilament motor activity	p.T1582A(1)		breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CATTCTGGCGAGATGTGTTGT	0.458000														124			5		0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49162828	49162828	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr3:49162828G>A	uc003cwe.3	-	18	2877	c.2578C>T	c.(2578-2580)Cgc>Tgc	p.R860C	LAMB2_uc003cwf.1_Missense_Mutation_p.R860C	NM_002292	NP_002283	P55268	LAMB2_HUMAN	Homo sapiens laminin, beta 2 (laminin S) (LAMB2), mRNA.	860	Laminin EGF-like 7.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGGTCACAGCGAAGCCCAAAG	0.607000														182			6		0	0	1	0	0
MFHAS1	9258	broad.mit.edu	37	8	8748357	8748357	+	Missense_Mutation	SNP	T	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr8:8748357T>A	uc003wsj.1	-	0	2775	c.2212A>T	c.(2212-2214)Aat>Tat	p.N738Y		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	Homo sapiens malignant fibrous histiocytoma amplified sequence 1 (MFHAS1), mRNA.	738										endometrium(1)|kidney(3)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|stomach(1)	21		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		AAGAAGACATTGAGGATGTCG	0.587000														64			5		0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4854614	4854614	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr12:4854614C>T	uc001qne.1	+	4	972	c.880C>T	c.(880-882)Cgg>Tgg	p.R294W		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8) (GALNT8), mRNA.	294	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.R294Q(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						AATCTTGGCTCGGATTCAGGA	0.483000														99			6		0	0	1	0	0
CASP4	837	broad.mit.edu	37	11	104825546	104825546	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr11:104825546T>C	uc001pid.1	-	1	263	c.190A>G	c.(190-192)Aag>Gag	p.K64E	CASP4_uc001pib.1_Missense_Mutation_p.K8E|CASP4_uc009yxg.1_5'UTR|CASP4_uc010rux.1_Missense_Mutation_p.K64E|CASP4_uc010ruy.1_Missense_Mutation_p.K64E	NM_001225	NP_150649	P49662	CASP4_HUMAN	Homo sapiens caspase 4, apoptosis-related cysteine peptidase (CASP4), transcript variant alpha, mRNA.	64	CARD.				apoptosis|induction of apoptosis|proteolysis	intracellular	cysteine-type endopeptidase activity|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(2)	23		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000854)|Epithelial(105;0.00879)|all cancers(92;0.0357)		ATACGTTGCTTCTCTTGCATA	0.363000														166			4		0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884300	39884300	+	Silent	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr22:39884300C>T	uc003axv.4	+	1	1187	c.948C>T	c.(946-948)gaC>gaT	p.D316D	MGAT3_uc010gxy.3_Silent_p.D316D	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	Homo sapiens mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (MGAT3), transcript variant 1, mRNA.	316					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					TCATCATTGACGATGCGGACG	0.647000														10			15		0	0	1	0	0
SH3GL3	6457	broad.mit.edu	37	15	84286962	84286962	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr15:84286962T>C	uc002bjw.3	+	8	1162	c.967T>C	c.(967-969)Tat>Cat	p.Y323H	SH3GL3_uc002bjx.3_Missense_Mutation_p.Y254H|SH3GL3_uc002bju.3_Missense_Mutation_p.Y331H|SH3GL3_uc002bjv.3_Non-coding_Transcript	NM_003027	NP_003018	Q99963	SH3G3_HUMAN	Homo sapiens SH3-domain GRB2-like 3 (SH3GL3), transcript variant 1, mRNA.	323	SH3.				central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						TGAAAACTGGTATGAAGGAAT	0.398000														82			3		0	0	1	0	0
MAPK3	5595	broad.mit.edu	37	16	30128535	30128535	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr16:30128535A>G	uc002dws.3	-	5	947	c.847T>C	c.(847-849)Tct>Cct	p.S283P	BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.3_Missense_Mutation_p.S169P|MAPK3_uc002dwv.4_Intron|MAPK3_uc002dwt.3_Missense_Mutation_p.S283P	NM_002746	NP_002737	P27361	MK03_HUMAN	Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 1, mRNA.	283	Protein kinase.				MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Ras protein signal transduction|Toll signaling pathway|activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GAGGGCAGAGACTGTAGGTAG	0.532000														116			4		0	0	1	0	0
RBM3	5935	broad.mit.edu	37	X	48434802	48434802	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chrX:48434802C>T	uc004dkf.2	+	3	545	c.311C>T	c.(310-312)tCt>tTt	p.S104F		NM_006743	NP_006734	P98179	RBM3_HUMAN	Homo sapiens RNA binding motif (RNP1, RRM) protein 3 (RBM3), mRNA.	104	Gly-rich.				positive regulation of translation	dendrite|nucleus	RNA binding|nucleotide binding			endometrium(1)|large_intestine(1)|lung(1)|ovary(1)	4						CGCAGCTACTCTAGAGGTGAG	0.537000														63			5		0	0	1	0	0
QTRT1	81890	broad.mit.edu	37	19	10823283	10823283	+	Silent	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr19:10823283C>T	uc002mpr.3	+	6	865	c.840C>T	c.(838-840)tgC>tgT	p.C280C	DNM2_uc010dxk.2_5'Flank	NM_031209	NP_112486	Q9BXR0	TGT_HUMAN	Homo sapiens queuine tRNA-ribosyltransferase 1 (QTRT1), mRNA.	280					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			TGTTCGACTGCGTCTTCCCCA	0.642000														65			3		0	0	1	0	0
CDRT1	374286	broad.mit.edu	37	17	15534987	15534987	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr17:15534987G>A	uc002gor.1	-	4	1394	c.1057C>T	c.(1057-1059)Cgc>Tgc	p.R353C	CDRT1_uc002gow.3_Missense_Mutation_p.R137C|CDRT1_uc002gox.3_Missense_Mutation_p.R353C|CDRT1_uc002goy.3_Missense_Mutation_p.R223C			O95170	CDRT1_HUMAN	Homo sapiens tripartite motif containing 16 (TRIM16), mRNA.	194										endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(2;1.36e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0541)		CAATATTTGCGCTGAACAACG	0.483000														77			3		0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52365211	52365211	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr3:52365211G>A	uc011bef.2	+	6	1180	c.919G>A	c.(919-921)Gtc>Atc	p.V307I	DNAH1_uc003ddt.1_Missense_Mutation_p.V307I	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	Homo sapiens dynein, axonemal, heavy chain 1 (DNAH1), mRNA.	307	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGAGGTCGGCGTCCTGGACTA	0.577000														99			7		0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33575696	33575696	+	Silent	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr20:33575696C>T	uc002xbi.2	+	17	1838	c.1521C>T	c.(1519-1521)atC>atT	p.I507I	MIR499A_uc021wcg.1_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	Homo sapiens myosin, heavy chain 7B, cardiac muscle, beta (MYH7B), mRNA.	465	Myosin head-like.					membrane|myosin filament	ATP binding|actin binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TTCTGGACATCGCTGGGTTTG	0.602000														35			31		0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61832802	61832802	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr10:61832802C>T	uc001jky.3	-	36	8175	c.7837G>A	c.(7837-7839)Gca>Aca	p.A2613T	ANK3_uc001jkw.3_Intron|ANK3_uc009xpa.3_Intron|ANK3_uc001jkx.3_Intron|ANK3_uc010qih.2_Intron|ANK3_uc001jkz.4_Intron|ANK3_uc001jkv.3_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	Homo sapiens ankyrin 3, node of Ranvier (ankyrin G) (ANK3), transcript variant 1, mRNA.	2613					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTAGGGCGTGCCTTTTTCTCT	0.443000														178			4		0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53416356	53416356	+	Silent	SNP	T	C	C			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr12:53416356T>C	uc001sbh.4	+	5	818	c.612T>C	c.(610-612)gcT>gcC	p.A204A	EIF4B_uc009zmp.1_Non-coding_Transcript|EIF4B_uc010snu.2_Silent_p.A204A|EIF4B_uc010snv.2_Silent_p.A165A	NM_001417	NP_001408	P23588	IF4B_HUMAN	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), mRNA.	204	Arg-rich.|Asp-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity	p.P203R(1)		breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						CTCGTCCTGCTACAGACAGCT	0.433000														152			4		0	0	1	0	0
ARIH1	25820	broad.mit.edu	37	15	72873082	72873082	+	Missense_Mutation	SNP	C	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr15:72873082C>A	uc002aut.4	+	11	1540	c.1226C>A	c.(1225-1227)gCa>gAa	p.A409E		NM_005744	NP_005735	Q9Y4X5	ARI1_HUMAN	Homo sapiens ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) (ARIH1), mRNA.	409					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding	p.A409E(7)		endometrium(1)|kidney(4)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	14						CGATCTAGGGCAGCCCTGCAG	0.383000														89			9		1.58986e-06	1.64199e-06	1	1	0
ARHGAP15	55843	broad.mit.edu	37	2	143959765	143959765	+	Silent	SNP	A	G	G			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr2:143959765A>G	uc002tvm.4	+	2	379	c.228A>G	c.(226-228)gaA>gaG	p.E76E	ARHGAP15_uc010zbl.1_Silent_p.E76E	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	Homo sapiens Rho GTPase activating protein 15 (ARHGAP15), mRNA.	76					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	Rac GTPase activator activity|protein binding			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		CTCCATTGGAACAACTGGTGA	0.313000														155			4		0	0	1	0	0
PPAPDC3	84814	broad.mit.edu	37	9	134165625	134165625	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr9:134165625G>A	uc004cal.2	+	0	545	c.241G>A	c.(241-243)Gcc>Acc	p.A81T		NM_032728	NP_116117	Q8NBV4	PPAC3_HUMAN	Homo sapiens phosphatidic acid phosphatase type 2 domain containing 3 (PPAPDC3), mRNA.	81	interaction with MTOR (By similarity).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	hydrolase activity	p.A81A(1)		breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16	all_hematologic(7;0.0119)			OV - Ovarian serous cystadenocarcinoma(145;1.22e-05)|Epithelial(140;0.000173)		CAAGGGCATCGCCTTCAACTC	0.657000														59			49		0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153065877	153065877	+	Silent	SNP	C	T	T	rs140876127		TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr5:153065877C>T	uc011dcy.2	+	7	1179	c.1152C>T	c.(1150-1152)gaC>gaT	p.D384D	GRIA1_uc003lva.4_Silent_p.D374D|GRIA1_uc003luy.4_Silent_p.D374D|GRIA1_uc003luz.4_Silent_p.D279D|GRIA1_uc011dcv.2_Non-coding_Transcript|GRIA1_uc011dcw.2_Silent_p.D294D|GRIA1_uc011dcx.2_Silent_p.D305D|GRIA1_uc011dcz.2_Silent_p.D384D|GRIA1_uc010jia.1_Silent_p.D354D	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	Homo sapiens glutamate receptor, ionotropic, AMPA 1 (GRIA1), transcript variant 2, mRNA.	374					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	PDZ domain binding|alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.D374D(2)		NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TGAAACATGACGGCATCCGAA	0.502000														66			6		0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65946296	65946296	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr15:65946296C>T	uc010ujf.2	+	9	3466	c.3179C>T	c.(3178-3180)gCg>gTg	p.A1060V	SLC24A1_uc010uje.1_Intron|SLC24A1_uc010ujg.2_Missense_Mutation_p.A1030V|SLC24A1_uc010ujh.2_Missense_Mutation_p.A1042V|SLC24A1_uc010uji.2_Missense_Mutation_p.A387V	NM_004727	NP_004718	O60721	NCKX1_HUMAN	Homo sapiens solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 (SLC24A1), transcript variant 1, mRNA.	1060					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity	p.A1060V(2)		breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						TCTTCAATTGCGTCATGTAAA	0.383000														390			8		0	0	1	0	0
SLC43A1	8501	broad.mit.edu	37	11	57268329	57268329	+	Splice_Site	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr11:57268329C>T	uc001nkk.3	-	5	507	c.389_splice	c.e5-1	p.A130_splice	SLC43A1_uc001nkl.3_Splice_Site_p.A130_splice	NM_001198810	NP_001185739	O75387	LAT3_HUMAN	Homo sapiens solute carrier family 43, member 1 (SLC43A1), transcript variant 2, mRNA.	130					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	neutral amino acid transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						GGAGACAGAGCTGGAAAGGGG	0.562000														132			4		0	0	1	0	0
CYB561D2	11068	broad.mit.edu	37	3	50391044	50391044	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr3:50391044T>C	uc003dal.3	+	3	748	c.538T>C	c.(538-540)Tca>Cca	p.S180P	NPRL2_uc003daj.1_5'Flank|CYB561D2_uc003dam.3_Missense_Mutation_p.S180P	NM_007022	NP_008953	O14569	C56D2_HUMAN	Homo sapiens cytochrome b-561 domain containing 2 (CYB561D2), mRNA.	180	Cytochrome b561.				electron transport chain|transport	integral to membrane	metal ion binding			endometrium(1)|lung(1)|urinary_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGGCATGTGCTCACTCTGGTT	0.582000														85			4		0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374339	27374339	+	Nonsense_Mutation	SNP	C	T	T			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr16:27374339C>T	uc002don.3	+	10	1908	c.1666C>T	c.(1666-1668)Cga>Tga	p.R556*	IL4R_uc002dop.4_Nonsense_Mutation_p.R541*|IL4R_uc010bxy.3_Nonsense_Mutation_p.R556*|IL4R_uc002doo.3_Nonsense_Mutation_p.R396*	NM_000418	NP_000409	P24394	IL4RA_HUMAN	Homo sapiens interleukin 4 receptor (IL4R), transcript variant 1, mRNA.	556	Required for IRS1 activation and IL4- induced cell growth.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GATCCTCCGCCGAAATGTCCT	0.637000														76			3		0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152060616	152060616	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr1:152060616G>A	uc001ezo.1	-	1	69	c.4C>T	c.(4-6)Cct>Tct	p.P2S		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	Homo sapiens trichohyalin-like 1 (TCHHL1), mRNA.	2							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			AGGAGCTGAGGCATCTTTACA	0.448000														10			31		0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57438684	57438684	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr3:57438684delA	uc003dit.2	-	24	3784	c.3603delT	c.(3601-3603)aatfs	p.N1201fs		NM_178504	NP_848599	Q6ZR08	DYH12_HUMAN	Homo sapiens dynein, axonemal, heavy chain 12 (DNAH12), transcript variant 1, mRNA.	1201	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						GGGCATTCTCATTTTCCCAAT	0.368													---	82	---	---	7	---					
HMX1	3166	broad.mit.edu	37	4	8869718	8869718	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KM-8476-01A-11D-2310-10	TCGA-KM-8476-10A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5bebc389-de0d-45b8-9d2f-6476988c358a	69f24cd1-4ec4-4ef0-876f-4eda31a72245	g.chr4:8869718delA	uc003izz.1	-	1	951	c.748delT	c.(748-750)tggfs	p.W250fs		NM_018942	NP_061815	Q9NP08	HMX1_HUMAN	Homo sapiens H6 family homeobox 1 (HMX1), mRNA.	250					multicellular organismal development|negative regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										TTCTGGAACCAGATCTTAACC	0.701													---	4	---	---	2	---					
