Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC4A5	57835	broad.mit.edu	37	2	74492256	74492256	+	Missense_Mutation	SNP	G	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr2:74492256G>C	uc002sko.1	-	3	539	c.537C>G	c.(535-537)gaC>gaG	p.D179E	SLC4A5_uc002skl.3_Non-coding_Transcript|SLC4A5_uc002skn.3_Missense_Mutation_p.D179E|SLC4A5_uc010ffc.1_Missense_Mutation_p.D179E|SLC4A5_uc002skp.1_Missense_Mutation_p.D115E|SLC4A5_uc002sks.1_Missense_Mutation_p.D179E	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	Homo sapiens solute carrier family 4, sodium bicarbonate cotransporter, member 5 (SLC4A5), transcript variant a, mRNA.	179						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						AGGAGCCACTGTCCAAATCCA	0.617000														99			6		0	0	1	0	0
DNAJA2	10294	broad.mit.edu	37	16	46991077	46991077	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr16:46991077G>A	uc002eeo.2	-	8	1245	c.1103C>T	c.(1102-1104)aCa>aTa	p.T368I		NM_005880	NP_005871	O60884	DNJA2_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily A, member 2 (DNAJA2), mRNA.	368					positive regulation of cell proliferation|protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	14		all_cancers(37;0.00125)|all_lung(18;0.00338)|all_epithelial(9;0.00358)|Lung NSC(13;0.0309)|Breast(268;0.116)				TACCTCCTCTGTTTCTCCAAT	0.418000														92			9		0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135079031	135079031	+	Silent	SNP	T	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr7:135079031T>C	uc003vsv.2	-	9	1597	c.1266A>G	c.(1264-1266)gaA>gaG	p.E422E	CNOT4_uc011kpy.2_Silent_p.E422E|CNOT4_uc011kpz.2_Silent_p.E419E|CNOT4_uc003vst.3_Silent_p.E422E|CNOT4_uc003vss.3_Silent_p.E419E|CNOT4_uc003vsu.2_Silent_p.E419E	NM_001190848	NP_001177777	O95628	CNOT4_HUMAN	Homo sapiens CCR4-NOT transcription complex, subunit 4 (CNOT4), transcript variant 4, mRNA.	422					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	RNA binding|nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						GAACGGACAGTTCCTTCTCAA	0.488000														114			36		0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12501695	12501695	+	Missense_Mutation	SNP	C	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr19:12501695C>A	uc010dyt.3	-	3	1721	c.1517G>T	c.(1516-1518)tGt>tTt	p.C506F	ZNF799_uc002mts.4_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	Homo sapiens zinc finger protein 799 (ZNF799), mRNA.	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						ACATGTGTTACACTCATAAGG	0.388000														107			37		1.76056e-25	1.83391e-25	1	1	0
TMCO7	79613	broad.mit.edu	37	16	68961835	68961835	+	Missense_Mutation	SNP	C	G	G			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr16:68961835C>G	uc002ewi.4	+	12	2504	c.2492C>G	c.(2491-2493)tCt>tGt	p.S831C		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	Homo sapiens transmembrane and coiled-coil domains 7 (TMCO7), mRNA.	831						integral to membrane	binding			endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|prostate(2)	20		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		AGTCAGAAATCTGGAAGCGTA	0.522000														116			31		0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161220991	161220991	+	Missense_Mutation	SNP	T	G	G			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr3:161220991T>G	uc011bpb.2	+	3	695	c.695T>G	c.(694-696)aTg>aGg	p.M232R		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	Homo sapiens otolin 1 (OTOL1), mRNA.	232	Collagen-like 2.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						aagggggagatgggggagaag	0.577000														37			4		0	0	1	0	0
RNPEP	6051	broad.mit.edu	37	1	201969125	201969125	+	Missense_Mutation	SNP	C	T	T	rs140770038		TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr1:201969125C>T	uc001gxd.3	+	5	1215	c.1186C>T	c.(1186-1188)Cgc>Tgc	p.R396C	RNPEP_uc001gxe.3_Missense_Mutation_p.R97C	NM_020216	NP_064601	Q9H4A4	AMPB_HUMAN	Homo sapiens arginyl aminopeptidase (aminopeptidase B) (RNPEP), mRNA.	396					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			breast(1)|endometrium(4)|large_intestine(4)|lung(6)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		CAACAAGCTCCGCGTGAAGAT	0.567000											OREG0014093	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		197			6		0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230650546	230650546	+	Missense_Mutation	SNP	A	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr2:230650546A>C	uc002vpx.1	-	33	5049	c.4940T>G	c.(4939-4941)cTg>cGg	p.L1647R	TRIP12_uc021vxw.1_Missense_Mutation_p.L1632R|TRIP12_uc002vpy.1_Missense_Mutation_p.L1329R|TRIP12_uc002vpw.1_Missense_Mutation_p.L1599R	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	Homo sapiens thyroid hormone receptor interactor 12 (TRIP12), mRNA.	1599					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		CGCCTGTTTCAGCAGCTCCTC	0.463000														59			4		0	0	1	0	0
SEC23IP	11196	broad.mit.edu	37	10	121652313	121652313	+	Missense_Mutation	SNP	A	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr10:121652313A>C	uc001leu.2	+	0	229	c.19A>C	c.(19-21)Aac>Cac	p.N7H	SEC23IP_uc010qtc.2_5'UTR	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Homo sapiens SEC23 interacting protein (SEC23IP), transcript variant 1, mRNA.	7	Interaction with SEC23A.				Golgi organization|intracellular protein transport	ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment|endoplasmic reticulum	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GAGAAAACCTAACGGTGGCAG	0.612000														149			49		0	0	1	0	0
CDK13	8621	broad.mit.edu	37	7	40132819	40132819	+	Missense_Mutation	SNP	C	G	G			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr7:40132819C>G	uc003thh.4	+	12	3953	c.3671C>G	c.(3670-3672)cCt>cGt	p.P1224R	CDK13_uc003thi.4_Missense_Mutation_p.P1164R|CDK13_uc003thj.3_Missense_Mutation_p.P275R|CDK13_uc003thk.3_Missense_Mutation_p.P157R	NM_003718	NP_003709	Q14004	CDK13_HUMAN	Homo sapiens cyclin-dependent kinase 13 (CDK13), transcript variant 1, mRNA.	1224					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|RNA polymerase II carboxy-terminal domain kinase activity|cyclin-dependent protein kinase activity|protein binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(2)|prostate(2)|skin(5)|stomach(2)|urinary_tract(1)	49						CCTCCAGAACCTAGCACTCCG	0.453000														65			29		0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25464834	25464834	+	Nonsense_Mutation	SNP	G	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr10:25464834G>A	uc001isj.3	+	0	545	c.485G>A	c.(484-486)tGg>tAg	p.W162*	LOC100128811_uc010qde.1_Missense_Mutation_p.H40Y	NM_020752	NP_065803	Q5T848	GP158_HUMAN	Homo sapiens G protein-coupled receptor 158 (GPR158), mRNA.	162						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GCGCTGGTGTGGAGCCTTCTG	0.632000														18			14		0	0	1	0	0
ZNF101	94039	broad.mit.edu	37	19	19790063	19790063	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr19:19790063T>C	uc002nni.2	+	3	375	c.265T>C	c.(265-267)Tgt>Cgt	p.C89R	ZNF101_uc010ecg.2_5'UTR|ZNF101_uc002nnj.2_5'UTR	NM_033204	NP_149981	Q8IZC7	ZN101_HUMAN	Homo sapiens zinc finger protein 101 (ZNF101), mRNA.	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						GATTCCTGATTGTCACCTGAA	0.443000														169			5		0	0	1	0	0
WASH2P	375260	broad.mit.edu	37	2	114356198	114356198	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr2:114356198G>A	uc002tkh.3	+	5	734	c.676G>A	c.(676-678)Gga>Aga	p.G226R	WASH2P_uc002tka.3_Non-coding_Transcript|WASH2P_uc002tkd.3_Non-coding_Transcript					Homo sapiens WAS protein family homolog 2 pseudogene (WASH2P), non-coding RNA.																		CTCTGGGAAAGGACCTGGGGC	0.622000														79			4		0	0	1	0	0
C20orf111	51526	broad.mit.edu	37	20	42825743	42825743	+	Nonsense_Mutation	SNP	G	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr20:42825743G>C	uc002xlk.3	-	3	1080	c.828C>G	c.(826-828)taC>taG	p.Y276*		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	Homo sapiens chromosome 20 open reading frame 111 (C20orf111), mRNA.	276										breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	14		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			GAATATACAAGTAATACTCCA	0.448000														75			38		0	0	1	0	0
PACS1	55690	broad.mit.edu	37	11	66008957	66008957	+	Missense_Mutation	SNP	A	G	G			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr11:66008957A>G	uc001oha.2	+	21	2623	c.2489A>G	c.(2488-2490)cAc>cGc	p.H830R	PACS1_uc010rou.2_Missense_Mutation_p.H366R	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	Homo sapiens phosphofurin acidic cluster sorting protein 1 (PACS1), mRNA.	830					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						TGGCTGGGCCACCCCGGGGAG	0.617000														64			13		0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33577581	33577581	+	Missense_Mutation	SNP	G	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr20:33577581G>A	uc002xbi.2	+	19	2069	c.1752G>A	c.(1750-1752)atG>atA	p.M584I	MIR499A_uc021wcg.1_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	Homo sapiens myosin, heavy chain 7B, cardiac muscle, beta (MYH7B), mRNA.	542	Myosin head-like.					membrane|myosin filament	ATP binding|actin binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			AGGAATGCATGTTCCCCAAGG	0.587000														139			4		0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42143342	42143342	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr15:42143342C>T	uc001zos.3	-	64	10978	c.10645G>A	c.(10645-10647)Gct>Act	p.A3549T		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	Homo sapiens spectrin, beta, non-erythrocytic 5 (SPTBN5), mRNA.	3584	PH.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCTATGGAAGCTACTTTCTGA	0.617000														50			20		0	0	1	0	0
HCFC1	3054	broad.mit.edu	37	X	153220585	153220585	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chrX:153220585T>C	uc004fjp.3	-	16	3793	c.3265A>G	c.(3265-3267)Aac>Gac	p.N1089D		NM_005334	NP_005325	P51610	HCFC1_HUMAN	Homo sapiens host cell factor C1 (VP16-accessory protein) (HCFC1), mRNA.	1089					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex|MLL5-L complex|Set1C/COMPASS complex|mitochondrion	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					gtggcggtgttggtggtgCCC	0.642000														7			4		0	0	1	0	0
BMP8A	353500	broad.mit.edu	37	1	39987055	39987055	+	Silent	SNP	C	T	T			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr1:39987055C>T	uc001cdi.3	+	3	1027	c.681C>T	c.(679-681)agC>agT	p.S227S		NM_181809	NP_861525	Q7Z5Y6	BMP8A_HUMAN	Homo sapiens bone morphogenetic protein 8a (BMP8A), mRNA.	227					cartilage development|cell differentiation|growth|ossification	extracellular space	cytokine activity|growth factor activity			kidney(1)|large_intestine(2)|lung(1)|skin(1)	5	Lung NSC(20;2.08e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;9.69e-19)|Epithelial(16;9.34e-17)|all cancers(16;1.73e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CAGGGCACAGCGTGGATCCTG	0.672000														8			3		0	0	1	0	0
NCL	4691	broad.mit.edu	37	2	232325533	232325533	+	Missense_Mutation	SNP	T	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr2:232325533T>C	uc002vru.3	-	3	799	c.658A>G	c.(658-660)Aaa>Gaa	p.K220E	SNORD82_uc010fxw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	Homo sapiens nucleolin (NCL), mRNA.	220					angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	RNA binding|nucleotide binding|protein C-terminus binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		TTTGCAGCTTTCTTTCCTTTG	0.448000														201			91		0	0	1	0	0
MYBPHL	343263	broad.mit.edu	37	1	109840820	109840820	+	Missense_Mutation	SNP	C	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr1:109840820C>A	uc001dxk.1	-	1	255	c.205G>T	c.(205-207)Gac>Tac	p.D69Y	MYBPHL_uc010ovh.1_Missense_Mutation_p.D69Y|MYBPHL_uc001dxl.3_Intron	NM_001010985	NP_001010985	A2RUH7	MBPHL_HUMAN	Homo sapiens myosin binding protein H-like (MYBPHL), mRNA.	69	Ig-like C2-type 1.							p.G68W(1)		central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		TTCACTGTGTCCCCAACCTTC	0.532000														88			29		1.47197e-15	1.47197e-15	1	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178634608	178634608	+	Missense_Mutation	SNP	T	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr5:178634608T>A	uc003mjw.3	-	3	899	c.797A>T	c.(796-798)tAc>tTc	p.Y266F	ADAMTS2_uc011dgm.2_Missense_Mutation_p.Y266F	NM_014244	NP_055059	O95450	ATS2_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 2 (ADAMTS2), transcript variant 1, mRNA.	266	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CTCGATGTTGTAGTCATCGTC	0.612000														92			3		0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63174364	63174364	+	Silent	SNP	C	T	T			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr14:63174364C>T	uc001xfx.3	-	10	2880	c.2829G>A	c.(2827-2829)tcG>tcA	p.S943S	KCNH5_uc001xfy.3_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 5 (KCNH5), transcript variant 1, mRNA.	943	CAD (involved in subunit assembly) (By similarity).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity	p.S943L(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CGCTTTTTTCCGACAGTATTT	0.478000														86			37		0	0	1	0	0
BIRC3	330	broad.mit.edu	37	11	102206944	102206944	+	Missense_Mutation	SNP	T	G	G			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr11:102206944T>G	uc001pgx.3	+	6	4367	c.1572T>G	c.(1570-1572)caT>caG	p.H524Q		NM_182962	NP_892007	Q13489	BIRC3_HUMAN	Homo sapiens baculoviral IAP repeat containing 3 (BIRC3), transcript variant 2, mRNA.	524	CARD.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|ovary(3)|skin(1)	21	all_cancers(8;0.00044)|all_epithelial(12;0.00348)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0093)	Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0146)		TATATGAGCATTTATTTGGTG	0.294000			T	MALT1	MALT									20			15		0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228471449	228471449	+	Missense_Mutation	SNP	C	T	T			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr1:228471449C>T	uc009xez.1	+	32	9027	c.8983C>T	c.(8983-8985)Cgg>Tgg	p.R2995W	OBSCN_uc001hsn.3_Missense_Mutation_p.R2995W|OBSCN_uc001hsp.1_Missense_Mutation_p.R694W|OBSCN_uc001hsq.1_Missense_Mutation_p.R251W	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	Homo sapiens obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (OBSCN), transcript variant 2, mRNA.	2995	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	M band|Z disc|cytosol	ATP binding|Rho guanyl-nucleotide exchange factor activity|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCCCAGTCCCGGGCCCAGCT	0.647000														117			4		0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	206110537	206110538	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr2:206110537_206110538insA	uc002var.2	+	15	2383_2384	c.2176_2177insA	c.(2176-2178)caafs	p.Q726fs	PARD3B_uc010fub.2_Frame_Shift_Ins_p.Q726fs|PARD3B_uc002vao.2_Frame_Shift_Ins_p.Q726fs|PARD3B_uc002vap.2_Frame_Shift_Ins_p.Q664fs|PARD3B_uc002vaq.2_Frame_Shift_Ins_p.Q726fs	NM_205863	NP_689739	Q8TEW8	PAR3L_HUMAN	Homo sapiens par-3 partitioning defective 3 homolog B (C. elegans) (PARD3B), mRNA.	726					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		ATTGGCTGGACAAAAATCGGGT	0.401													---	166	---	---	51	---					
CAMK2N2	94032	broad.mit.edu	37	3	183977958	183977959	+	Frame_Shift_Del	DEL	GG	-	-			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr3:183977958_183977959delGG	uc003fnj.1	-	1	404_405	c.226_227delCC	c.(226-228)ccgfs	p.P76fs	ECE2_uc003fni.4_Intron	NM_033259	NP_150284	Q96S95	CK2N2_HUMAN	Homo sapiens calcium/calmodulin-dependent protein kinase II inhibitor 2 (CAMK2N2), mRNA.	76						cytosol|nucleus	protein kinase inhibitor activity					all_cancers(143;1.09e-10)|Ovarian(172;0.0339)		Epithelial(37;2.51e-33)|OV - Ovarian serous cystadenocarcinoma(80;5.69e-22)			CACTCCGGACGGCGGCTTCTCC	0.767													---	4	---	---	2	---					
ANKRD17	26057	broad.mit.edu	37	4	74012976	74012979	+	Frame_Shift_Del	DEL	TAAC	-	-			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr4:74012976_74012979delTAAC	uc003hgp.3	-	8	1855_1858	c.1738_1741delGTTA	c.(1738-1743)gttaaafs	p.V580fs	ANKRD17_uc003hgo.3_Frame_Shift_Del_p.V467fs|ANKRD17_uc003hgq.3_Frame_Shift_Del_p.V580fs|ANKRD17_uc003hgr.3_Frame_Shift_Del_p.V580fs|ANKRD17_uc011cbd.1_Intron	NM_032217	NP_115593	O75179	ANR17_HUMAN	Homo sapiens ankyrin repeat domain 17 (ANKRD17), transcript variant 1, mRNA.	580					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AATAAGTATTTAACTAACTCCAAA	0.363													---	77	---	---	39	---					
ZSWIM6	57688	broad.mit.edu	37	5	60822215	60822215	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr5:60822215delA	uc003jsr.3	+	6	1829	c.1829delA	c.(1828-1830)caafs	p.Q610fs		NM_020928	NP_065979	Q9HCJ5	ZSWM6_HUMAN	Homo sapiens zinc finger, SWIM-type containing 6 (ZSWIM6), mRNA.	610							zinc ion binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)	8						TTCCGAACCCAAAAAAAAGGT	0.408													---	174	---	---	8	---					
GABRR2	2570	broad.mit.edu	37	6	89977730	89977731	+	Splice_Site	INS	-	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr6:89977730_89977731insA	uc003pnb.2	-	5	678	c.670_splice	c.e5+1	p.Y224_splice	GABRR2_uc011dzx.1_Splice_Site_p.Y100_splice	NM_002043	NP_002034	P28476	GBRR2_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) receptor, rho 2 (GABRR2), mRNA.	224					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	GABA-A receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TGCTGATACTTACAGCTCTCCA	0.480													---	307	---	---	17	---					
TSC1	7248	broad.mit.edu	37	9	135779084	135779093	+	Frame_Shift_Del	DEL	CGGAGGAGCC	-	-			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr9:135779084_135779093delCGGAGGAGCC	uc004cca.2	-	16	2387_2396	c.2153_2162delGGCTCCTCCG	c.(2152-2163)cggctcctccgcfs	p.R718fs	TSC1_uc004ccb.3_Frame_Shift_Del_p.R717fs|TSC1_uc011mcq.1_Frame_Shift_Del_p.R667fs|TSC1_uc011mcr.2_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	Homo sapiens tuberous sclerosis 1 (TSC1), transcript variant 1, mRNA.	718					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of TOR signaling cascade|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of translation|positive regulation of focal adhesion assembly|rRNA export from nucleus|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly	TSC1-TSC2 complex|cell cortex|lamellipodium|membrane	chaperone binding|protein N-terminus binding	p.R721fs*9(2)|p.?(1)		NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		GATCACCTTGCGGAGGAGCCGCCTGTTCCG	0.533			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				---	43	---	---	50	---					
RBM14	10432	broad.mit.edu	37	11	66384364	66384365	+	Frame_Shift_Ins	INS	-	T	T			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr11:66384364_66384365insT	uc001oit.3	+	0	312_313	c.173_174insT	c.(172-174)cacfs	p.H58fs	RBM14_uc009yri.3_Frame_Shift_Ins_p.H58fs|RBM14_uc009yrh.3_Frame_Shift_Ins_p.H58fs|RBM14_uc009yrj.3_5'UTR|RBM14_uc009yrk.3_Frame_Shift_Ins_p.H58fs|RBM14_uc021qmb.1_Frame_Shift_Ins_p.H58fs	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	Homo sapiens RNA binding motif protein 14 (RBM14), transcript variant 1, mRNA.	58	RRM 1.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	RNA binding|RNA polymerase II transcription cofactor activity|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging		RBM14/PACS1(2)	breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CTGCACGGCCACGAGCTGCGGC	0.644													---	4	---	---	2	---					
AMDHD2	51005	broad.mit.edu	37	16	2570776	2570776	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr16:2570776delT	uc010uwc.2	+	1	187	c.90delT	c.(88-90)gatfs	p.D30fs	AMDHD2_uc002cqp.3_Frame_Shift_Del_p.D30fs|AMDHD2_uc002cqq.3_Frame_Shift_Del_p.D30fs|AMDHD2_uc010uwd.2_Intron	NM_001145815	NP_001139287	Q9Y303	NAGA_HUMAN	Homo sapiens amidohydrolase domain containing 2 (AMDHD2), transcript variant 2, mRNA.	30					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)|skin(2)|urinary_tract(2)	19						CCAGGGAGGATCTGTGGGTGC	0.746													---	4	---	---	2	---					
AMDHD2	51005	broad.mit.edu	37	16	2570778	2570778	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr16:2570778delT	uc010uwc.2	+	1	189	c.92delT	c.(91-93)ctgfs	p.L31fs	AMDHD2_uc002cqp.3_Frame_Shift_Del_p.L31fs|AMDHD2_uc002cqq.3_Frame_Shift_Del_p.L31fs|AMDHD2_uc010uwd.2_Intron	NM_001145815	NP_001139287	Q9Y303	NAGA_HUMAN	Homo sapiens amidohydrolase domain containing 2 (AMDHD2), transcript variant 2, mRNA.	31					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)|skin(2)|urinary_tract(2)	19						AGGGAGGATCTGTGGGTGCGC	0.741													---	4	---	---	2	---					
BCAR1	9564	broad.mit.edu	37	16	75263529	75263530	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr16:75263529_75263530delCT	uc002fdv.3	-	6	2638_2639	c.2492_2493delAG	c.(2491-2493)aagfs	p.K831fs	BCAR1_uc002fdt.3_Frame_Shift_Del_p.K284fs|BCAR1_uc002fdu.3_Frame_Shift_Del_p.K621fs|BCAR1_uc010vna.2_Frame_Shift_Del_p.K829fs|BCAR1_uc010cgu.3_Frame_Shift_Del_p.K849fs|BCAR1_uc010vnb.2_Frame_Shift_Del_p.K877fs|BCAR1_uc002fdw.3_Frame_Shift_Del_p.K831fs|BCAR1_uc010vnc.2_Frame_Shift_Del_p.K683fs|BCAR1_uc010vnd.2_Frame_Shift_Del_p.K849fs|BCAR1_uc002fdx.3_Frame_Shift_Del_p.K849fs	NM_014567	NP_055382	P56945	BCAR1_HUMAN	Homo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6, mRNA.	831					B cell receptor signaling pathway|G-protein coupled receptor protein signaling pathway|T cell receptor signaling pathway|actin filament organization|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth	cytosol|focal adhesion|membrane fraction|ruffle	SH3 domain binding|protein kinase binding|protein phosphatase binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGGCAGCGGCCTTGGTGGTGGC	0.668													---	4	---	---	2	---					
BCAR1	9564	broad.mit.edu	37	16	75263533	75263534	+	Frame_Shift_Ins	INS	-	T	T			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr16:75263533_75263534insT	uc002fdv.3	-	6	2634_2635	c.2488_2489insA	c.(2488-2490)accfs	p.T830fs	BCAR1_uc002fdt.3_Frame_Shift_Ins_p.T283fs|BCAR1_uc002fdu.3_Frame_Shift_Ins_p.T620fs|BCAR1_uc010vna.2_Frame_Shift_Ins_p.T828fs|BCAR1_uc010cgu.3_Frame_Shift_Ins_p.T848fs|BCAR1_uc010vnb.2_Frame_Shift_Ins_p.T876fs|BCAR1_uc002fdw.3_Frame_Shift_Ins_p.T830fs|BCAR1_uc010vnc.2_Frame_Shift_Ins_p.T682fs|BCAR1_uc010vnd.2_Frame_Shift_Ins_p.T848fs|BCAR1_uc002fdx.3_Frame_Shift_Ins_p.T848fs	NM_014567	NP_055382	P56945	BCAR1_HUMAN	Homo sapiens breast cancer anti-estrogen resistance 1 (BCAR1), transcript variant 6, mRNA.	830					B cell receptor signaling pathway|G-protein coupled receptor protein signaling pathway|T cell receptor signaling pathway|actin filament organization|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth	cytosol|focal adhesion|membrane fraction|ruffle	SH3 domain binding|protein kinase binding|protein phosphatase binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		AGCGGCCTTGGTGGTGGCCACG	0.673													---	4	---	---	2	---					
CCDC144B	284047	broad.mit.edu	37	17	18454926	18454927	+	RNA	INS	-	C	C			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr17:18454926_18454927insC	uc002gua.4	-	14		c.4158_4159insG								Homo sapiens coiled-coil domain containing 144B (pseudogene) (CCDC144B), non-coding RNA.											NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(6)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	36						GCAAGGTGACTTAGGACTGGCC	0.426													---	5	---	---	3	---					
LMNB2	84823	broad.mit.edu	37	19	2434856	2434857	+	Frame_Shift_Ins	INS	-	A	A	rs140495297		TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr19:2434856_2434857insA	uc002lvy.3	-	5	937_938	c.850_851insT	c.(850-852)cgcfs	p.R284fs		NM_032737	NP_116126	Q03252	LMNB2_HUMAN	Homo sapiens lamin B2 (LMNB2), mRNA.	284	Coil 2.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCTCCTCGCGAGCCGCACTG	0.708													---	4	---	---	2	---					
TMED1	11018	broad.mit.edu	37	19	10943859	10943865	+	Frame_Shift_Del	DEL	CCAGCCG	-	-	rs140257821	byFrequency	TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr19:10943859_10943865delCCAGCCG	uc002mpy.3	-	3	606_612	c.490_496delCGGCTGG	c.(490-498)cggctggagfs	p.R164fs	DNM2_uc002mpx.1_3'UTR	NM_006858	NP_006849	Q13445	TMED1_HUMAN	Homo sapiens transmembrane emp24 protein transport domain containing 1 (TMED1), mRNA.	164					cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			breast(1)|central_nervous_system(2)|lung(2)|ovary(3)|prostate(1)|skin(1)	10						ATGCTGCGCTCCAGCCGGGTCCGCATG	0.623													---	55	---	---	14	---					
GIPC1	10755	broad.mit.edu	37	19	14593617	14593618	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chr19:14593617_14593618insA	uc002myt.3	-	3	441_442	c.171_172insT	c.(169-174)cgcctcfs	p.R57fs	GIPC1_uc002myv.3_Intron|GIPC1_uc002myu.3_Frame_Shift_Ins_p.R57fs|GIPC1_uc002myw.3_Intron|GIPC1_uc002myx.3_Frame_Shift_Ins_p.R57fs|GIPC1_uc002myy.3_Intron	NM_005716	NP_974223	O14908	GIPC1_HUMAN	Homo sapiens GIPC PDZ domain containing family, member 1 (GIPC1), transcript variant 1, mRNA.	57					G-protein coupled receptor protein signaling pathway|endothelial cell migration|glutamate secretion|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|protein targeting|regulation of protein stability|regulation of synaptic plasticity|synaptic transmission	cell cortex|dendritic shaft|dendritic spine|membrane fraction|soluble fraction|synaptic vesicle|vesicle membrane	actin binding|myosin binding|protein homodimerization activity|receptor binding			endometrium(1)|lung(4)|upper_aerodigestive_tract(1)	6						TGGAACACGAGGCGGGGCCGCA	0.718													---	6	---	---	3	---					
WWC3	55841	broad.mit.edu	37	X	10085451	10085452	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KM-8639-01A-11D-2397-10	TCGA-KM-8639-10A-01D-2397-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0b811c6a-8f05-44bd-ac33-fb720d189e71	04e0d4a3-5826-41d0-9e72-19c5d4ce08ff	g.chrX:10085451_10085452insA	uc004csx.4	+	10	1550_1551	c.1352_1353insA	c.(1351-1353)tcgfs	p.S451fs	WWC3_uc010nds.3_Frame_Shift_Ins_p.S115fs|WWC3_uc010ndt.3_Non-coding_Transcript	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	Homo sapiens WWC family member 3 (WWC3), mRNA.	451	Ser-rich.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						TCCCTGGCATCGCTGTCCTCCC	0.698													---	4	---	---	2	---					
