Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GIMAP8	155038	broad.mit.edu	37	7	150171183	150171183	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr7:150171183C>T	uc003whj.3	+	3	1096	c.766C>T	c.(766-768)Cgc>Tgc	p.R256C		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	Homo sapiens GTPase, IMAP family member 8 (GIMAP8), mRNA.	256						Golgi apparatus|endoplasmic reticulum|mitochondrion	GTP binding	p.R256R(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TGTGGGGAAACGCGGTGCTGG	0.557000														83			9		0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142175380	142175380	+	Silent	SNP	G	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr8:142175380G>A	uc003yvy.3	+	10	1583	c.1305G>A	c.(1303-1305)gaG>gaA	p.E435E	DENND3_uc010mep.3_Silent_p.E396E|DENND3_uc003yvz.1_Silent_p.E119E	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	Homo sapiens DENN/MADD domain containing 3 (DENND3), mRNA.	435										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCAGTCGGAGGAGGACAGGT	0.468000														82			4		0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142221657	142221657	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr8:142221657G>A	uc003ywd.1	-	7	2589	c.2281C>T	c.(2281-2283)Ctt>Ttt	p.L761F	SLC45A4_uc022bbx.1_5'Flank|SLC45A4_uc003ywc.1_3'UTR|SLC45A4_uc010meq.1_3'UTR	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	Homo sapiens solute carrier family 45, member 4 (SLC45A4), mRNA.	0					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AGGAAAAGAAGATACGTCATT	0.493000														99			14		0	0	1	0	0
ZCCHC2	54877	broad.mit.edu	37	18	60242420	60242420	+	Missense_Mutation	SNP	A	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr18:60242420A>T	uc002lip.4	+	12	3106	c.3106A>T	c.(3106-3108)Aat>Tat	p.N1036Y	ZCCHC2_uc002lio.2_Non-coding_Transcript|ZCCHC2_uc002liq.3_Missense_Mutation_p.N506Y	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	Homo sapiens zinc finger, CCHC domain containing 2 (ZCCHC2), mRNA.	1036					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25						CTATTATCCTAATCCAATGCC	0.493000														87			26		0	0	1	0	0
NAA40	79829	broad.mit.edu	37	11	63719920	63719920	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr11:63719920G>A	uc009yoz.3	+	4	420	c.293G>A	c.(292-294)cGg>cAg	p.R98Q	NAA40_uc010rmw.2_Missense_Mutation_p.R58Q|NAA40_uc010rmx.2_Missense_Mutation_p.R77Q|NAA40_uc010rmy.2_5'Flank	NM_024771	NP_079047	Q86UY6	NAA40_HUMAN	Homo sapiens N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae) (NAA40), mRNA.	98	N-acetyltransferase.						N-acetyltransferase activity			NS(1)|endometrium(1)|lung(2)|prostate(1)	5						CGAGAGAAACGGGAGGAAATG	0.577000														49			48		0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	A	A	rs143435240	byFrequency	TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chrX:51076024G>A	uc004dph.3	+	1	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_uc004dpi.4_Silent_p.E69E	NM_153183	NP_694853	Q8NFP7	NUD10_HUMAN	Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 10 (NUDT10), mRNA.	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(16)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000														65			5		0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180057729	180057729	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr5:180057729C>T	uc003mlz.4	-	2	305	c.226G>A	c.(226-228)Gag>Aag	p.E76K	FLT4_uc003mma.4_Missense_Mutation_p.E76K|FLT4_uc003mmb.1_5'Flank|FLT4_uc011dgy.2_Missense_Mutation_p.E76K|FLT4_uc011dgz.1_Missense_Mutation_p.E76K|FLT4_uc011dha.1_Missense_Mutation_p.E76K	NM_182925	NP_891555	P35916	VGFR3_HUMAN	Homo sapiens fms-related tyrosine kinase 4 (FLT4), transcript variant 1, mRNA.	76	Ig-like C2-type 1.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCCGTGTCCTCGCTGTCCTTG	0.662000														28			7		0	0	1	0	0
CTH	1491	broad.mit.edu	37	1	70897872	70897872	+	Silent	SNP	C	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr1:70897872C>A	uc001dfd.3	+	7	1029	c.831C>A	c.(829-831)gcC>gcA	p.A277A	CTH_uc009wbl.2_Non-coding_Transcript|CTH_uc010oqq.2_Silent_p.A245A|CTH_uc001dfe.3_Silent_p.A233A	NM_001902	NP_001893	P32929	CGL_HUMAN	Homo sapiens cystathionase (cystathionine gamma-lyase) (CTH), transcript variant 1, mRNA.	277					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	L-cysteine desulfhydrase activity|cystathionine gamma-lyase activity|pyridoxal phosphate binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TGGCAGTTGCCCAGTTCCTGG	0.403000														66			29		6.04164e-23	6.61704e-23	1	1	0
TNFRSF10C	8794	broad.mit.edu	37	8	22974315	22974315	+	Missense_Mutation	SNP	A	C	C	rs61736405		TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr8:22974315A>C	uc003xcy.3	+	4	859	c.551A>C	c.(550-552)aAc>aCc	p.N184T	TNFRSF10C_uc011kzr.2_Non-coding_Transcript	NM_003841	NP_003832	O14798	TR10C_HUMAN	Homo sapiens tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain (TNFRSF10C), mRNA.	184					apoptosis	anchored to membrane|integral to plasma membrane	TRAIL binding|transmembrane receptor activity	p.N184T(2)		endometrium(1)|large_intestine(6)|lung(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	15		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		GAGACAATGAACACCAGCCCG	0.602000														66			5		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117887	117887	+	RNA	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chrGL000205.1:117887C>T	uc002kgk.4	+	0		c.1265C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		TCTCAACGAACAAAACTACCA	0.522000														45			4		0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1073206	1073206	+	Silent	SNP	C	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr19:1073206C>A	uc002lqz.1	+	2	711	c.480C>A	c.(478-480)gtC>gtA	p.V160V	HMHA1_uc010xgd.1_Silent_p.V176V|HMHA1_uc010xge.1_5'UTR|HMHA1_uc002lra.1_5'UTR|HMHA1_uc002lrb.1_Silent_p.V43V	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	Homo sapiens histocompatibility (minor) HA-1 (HMHA1), mRNA.	160					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCTGCGTGTCATGCATCAGA	0.647000														10			5		2.17888e-05	2.27792e-05	1	1	0
KRT84	3890	broad.mit.edu	37	12	52777475	52777475	+	Silent	SNP	G	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr12:52777475G>A	uc001sah.1	-	1	702	c.654C>T	c.(652-654)atC>atT	p.I218I		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	Homo sapiens keratin 84 (KRT84), mRNA.	218	Coil 1B.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GCAGGTTGGTGATGTAGCTCT	0.547000														63			10		0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394949	154394949	+	Silent	SNP	T	C	C			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr5:154394949T>C	uc010jih.1	+	0	1690	c.1530T>C	c.(1528-1530)gcT>gcC	p.A510A		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	Homo sapiens kinesin family member 4B (KIF4B), mRNA.	510					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CTTCTGACGCTTTTACCACTC	0.488000														53			4		0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56693673	56693673	+	Nonsense_Mutation	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr17:56693673C>T	uc010dcz.2	-	6	766	c.648G>A	c.(646-648)tgG>tgA	p.W216*	TEX14_uc002iwr.2_Intron|TEX14_uc002iws.2_Intron|TEX14_uc010dda.2_Intron	NM_001201457	NP_001188386	Q8IWB6	TEX14_HUMAN	Homo sapiens testis expressed 14 (TEX14), transcript variant 3, mRNA.	216						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AAAACTGAAACCAAGGCATAG	0.443000														21			6		0	0	1	0	0
HHIPL2	79802	broad.mit.edu	37	1	222721242	222721242	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr1:222721242C>T	uc001hnh.1	-	0	203	c.145G>A	c.(145-147)Ggg>Agg	p.G49R		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	Homo sapiens HHIP-like 2 (HHIPL2), mRNA.	49					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(7)|lung(28)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59				GBM - Glioblastoma multiforme(131;0.0185)		AAAGGGGGCCCGTAATCCAGG	0.617000														52			10		0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50596997	50596997	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr7:50596997C>T	uc003tpg.4	-	4	680	c.479G>A	c.(478-480)cGg>cAg	p.R160Q	DDC_uc022ade.1_Missense_Mutation_p.R82Q|DDC_uc003tpf.4_Missense_Mutation_p.R160Q|DDC_uc022adb.1_Missense_Mutation_p.R122Q|DDC_uc022adc.1_Missense_Mutation_p.R160Q|DDC_uc022add.1_Intron|DDC_uc022adf.1_Missense_Mutation_p.R160Q|LOC100129427_uc022adg.1_5'Flank	NM_001082971	NP_001076440	P20711	DDC_HUMAN	Homo sapiens dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC), transcript variant 1, mRNA.	160	2 X approximate tandem repeats.				cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CACTTTGGTCCGAGCGGCCAG	0.557000														158			16		0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31266429	31266429	+	Silent	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr22:31266429C>T	uc003aiy.1	+	2	971	c.867C>T	c.(865-867)gaC>gaT	p.D289D	OSBP2_uc011ala.1_Silent_p.D124D|OSBP2_uc010gwc.1_Silent_p.D116D|OSBP2_uc003aix.1_Silent_p.D289D|OSBP2_uc011alb.1_Silent_p.D289D|OSBP2_uc003aiz.1_Silent_p.D289D|OSBP2_uc003aja.1_5'UTR|OSBP2_uc011alc.2_Silent_p.D31D	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	Homo sapiens oxysterol binding protein 2 (OSBP2), transcript variant 1, mRNA.	289					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						ACTCTGGGGACGACGACGAGG	0.557000														33			6		0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121471492	121471492	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr12:121471492C>A	uc001tzj.1	-	1	259	c.253G>T	c.(253-255)Gtg>Ttg	p.V85L	OASL_uc001tzk.1_Missense_Mutation_p.V85L	NM_003733	NP_003724	Q15646	OASL_HUMAN	Homo sapiens 2'-5'-oligoadenylate synthetase-like (OASL), transcript variant 1, mRNA.	85					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGAAACGCCACCAGCTCCACC	0.577000														33			6		3.59834e-05	3.59834e-05	1	1	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	G	G	rs138671696	by1000genomes	TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr17:62968690A>G	uc002jez.3	-	3		c.641T>C			AMZ2P1_uc002jfa.3_Non-coding_Transcript|AMZ2P1_uc002jfb.3_Non-coding_Transcript|AMZ2P1_uc010del.2_Non-coding_Transcript					Homo sapiens archaelysin family metallopeptidase 2 pseudogene 1 (AMZ2P1), non-coding RNA.																		AAAATTCCACAAGTCTCTTGG	0.373000														88			5		0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182677	57182677	+	Silent	SNP	G	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr4:57182677G>A	uc003hbk.2	+	7	3400	c.3009G>A	c.(3007-3009)ccG>ccA	p.P1003P	KIAA1211_uc010iha.2_Silent_p.P996P|KIAA1211_uc011bzz.1_Silent_p.P913P|KIAA1211_uc003hbm.1_Silent_p.P889P	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	Homo sapiens KIAA1211 (KIAA1211), mRNA.	1003	Pro-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CAAGTGAGCCGTCCAAGGAGG	0.657000														27			6		0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150445701	150445701	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr1:150445701C>T	uc009wlr.3	+	10	4478	c.4277C>T	c.(4276-4278)cCt>cTt	p.P1426L	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.4_Missense_Mutation_p.P1400L	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Homo sapiens regulation of nuclear pre-mRNA domain containing 2 (RPRD2), mRNA.	1426	Pro-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CCTAGGGAACCTTTTCTCAGC	0.567000														106			4		0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28926018	28926018	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr18:28926018G>A	uc002kwp.3	+	13	2169	c.1957G>A	c.(1957-1959)Gga>Aga	p.G653R	DSG1_uc010xbp.2_Missense_Mutation_p.G12R|U6_uc021uin.1_5'Flank	NM_001942	NP_001933	Q02413	DSG1_HUMAN	Homo sapiens desmoglein 1 (DSG1), mRNA.	653					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GAGAATGACAGGATTTGAACT	0.353000														32			40		0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65245965	65245965	+	Splice_Site	SNP	C	T	T			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr14:65245965C>T	uc001xht.3	-	21	4525	c.4474_splice	c.e21-1	p.L1492_splice	SPTB_uc001xhr.3_Splice_Site_p.L1492_splice|SPTB_uc001xhs.3_Splice_Site_p.L1492_splice|SPTB_uc001xhu.3_Splice_Site_p.L1492_splice|SPTB_uc010aqi.3_Splice_Site_p.L153_splice	NM_000347	NP_000338	P11277	SPTB1_HUMAN	Homo sapiens spectrin, beta, erythrocytic (SPTB), transcript variant 2, mRNA.	1492					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCACCCAAAGCTGCAGAGACC	0.572000														68			7		0	0	1	0	0
RBPJ	3516	broad.mit.edu	37	4	26432510	26432511	+	Frame_Shift_Ins	INS	-	G	G	rs1064403		TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr4:26432510_26432511insG	uc003grx.2	+	11	1620_1621	c.1384_1385insG	c.(1384-1386)cgafs	p.R462fs	RBPJ_uc003gry.2_Frame_Shift_Ins_p.R447fs|RBPJ_uc003grz.2_Frame_Shift_Ins_p.R462fs|RBPJ_uc003gsa.2_Frame_Shift_Ins_p.R448fs|RBPJ_uc003gsb.2_Frame_Shift_Ins_p.R449fs	NM_005349	NP_005340	Q06330	SUH_HUMAN	Homo sapiens recombination signal binding protein for immunoglobulin kappa J region (RBPJ), transcript variant 1, mRNA.	462				R -> P (in Ref. 1; AAA60258).	DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)	15		Breast(46;0.0503)				AGCAATCCTTCGAGCCAATTCA	0.500													---	164	---	---	8	---					
DSPP	1834	broad.mit.edu	37	4	88536259	88536264	+	In_Frame_Del	DEL	CAGTGA	-	-			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr4:88536259_88536264delCAGTGA	uc003hqu.3	+	4	2565_2570	c.2445_2450delCAGTGA	c.(2443-2451)agcagtgat>agt	p.SD818del		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	Homo sapiens dentin sialophosphoprotein (DSPP), mRNA.	818	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		gcagtgacagcagtgatagcgacagc	0.515													---	384	---	---	8	---					
PABPC4L	132430	broad.mit.edu	37	4	135122069	135122070	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr4:135122069_135122070insA	uc010ioe.3	-	1	362_363	c.279_280insT	c.(277-282)cctgtgfs	p.P93fs		NM_001114734	NP_001108206			Homo sapiens poly(A) binding protein, cytoplasmic 4-like (PABPC4L), mRNA.											breast(1)|endometrium(2)	3						ATGGACAGCACAGGCCCCACAG	0.584													---	124	---	---	7	---					
HSF5	124535	broad.mit.edu	37	17	56565433	56565434	+	In_Frame_Ins	INS	-	CGGCCC	CGGCCC			TCGA-KN-8419-01A-11D-2310-10	TCGA-KN-8419-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a592e80a-3b1a-46aa-be30-bcd87d6bca6f	04adced3-96c5-4ec2-8e06-293544f0c3d7	g.chr17:56565433_56565434insCGGCCC	uc002iwi.1	-	0	326_327	c.202_203insGGGCCG	c.(202-204)gag>gGGGCCGag	p.67_68insGA		NM_001080439	NP_001073908	Q4G112	HSF5_HUMAN	Homo sapiens heat shock transcription factor family member 5 (HSF5), mRNA.	67						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GAGCTCGGGCTcggccccggcc	0.723													---	5	---	---	3	---					
