Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SRSF6	6431	broad.mit.edu	37	20	42089576	42089576	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr20:42089576C>T	uc010zwg.2	+	5	1078	c.908C>T	c.(907-909)tCg>tTg	p.S303L	SRSF6_uc002xki.3_Missense_Mutation_p.S174L	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	Homo sapiens serine/arginine-rich splicing factor 6 (SRSF6), transcript variant 1, mRNA.	303	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	RNA binding|nucleotide binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						CGTTCCAATTCGCCGCTACCT	0.493000														70			4		0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19744529	19744529	+	Silent	SNP	G	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr21:19744529G>A	uc002ykw.3	-	5	676	c.645C>T	c.(643-645)gaC>gaT	p.D215D		NM_002772	NP_002763	P98073	ENTK_HUMAN	Homo sapiens transmembrane protease, serine 15 (TMPRSS15), mRNA.	215	LDL-receptor class A 1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TATTGTCTTCGTCAGAACCAT	0.443000														170			7		0	0	1	0	0
KBTBD6	89890	broad.mit.edu	37	13	41704863	41704863	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr13:41704863C>A	uc001uxu.1	-	0	2074	c.1785G>T	c.(1783-1785)tgG>tgT	p.W595C	AK056182_uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	Homo sapiens kelch repeat and BTB (POZ) domain containing 6 (KBTBD6), mRNA.	595							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CTATATTAATCCATTGGTCTC	0.438000														11			94		2.12943e-44	2.35358e-44	1	1	0
ATG2A	23130	broad.mit.edu	37	11	64664265	64664265	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr11:64664265C>T	uc001obx.3	-	37	5342	c.5227G>A	c.(5227-5229)Ggc>Agc	p.G1743S	ATG2A_uc001obw.3_Missense_Mutation_p.G508S	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	Homo sapiens ATG2 autophagy related 2 homolog A (S. cerevisiae) (ATG2A), mRNA.	1743							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						CCCAGCAGGCCGGGCAGCTGG	0.622000											OREG0004026	type=REGULATORY REGION|Gene=BC027481|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay		27			14		0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179401232	179401232	+	Silent	SNP	C	T	T			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr2:179401232C>T	uc021vsy.1	-	305	92763	c.92538G>A	c.(92536-92538)aaG>aaA	p.K30846K	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002umo.3_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Silent_p.K24541K|TTN_uc021vta.1_Silent_p.K24474K|TTN_uc021vtb.1_Silent_p.K24349K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	31773	Fibronectin type-III 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGCAGGTGGCTTCCAGGCCA	0.403000														31			4		0	0	1	0	0
DNASE2B	58511	broad.mit.edu	37	1	84876612	84876612	+	Silent	SNP	A	T	T			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr1:84876612A>T	uc001djt.1	+	3	510	c.477A>T	c.(475-477)ccA>ccT	p.P159P	DNASE2B_uc001dju.1_5'UTR|DNASE2B_uc009wch.1_5'UTR	NM_021233	NP_067056	Q8WZ79	DNS2B_HUMAN	Homo sapiens deoxyribonuclease II beta (DNASE2B), transcript variant 1, mRNA.	159					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		ATGATTATCCACCCACAGGGA	0.428000														4			28		0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886665	123886665	+	Silent	SNP	G	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr11:123886665G>A	uc010sac.2	+	0	384	c.384G>A	c.(382-384)ccG>ccA	p.P128P		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily G, member 4 (OR10G4), mRNA.	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TCAGTTACCCGCTCAGGTACA	0.557000														294			156		0	0	1	0	0
R3HDM1	23518	broad.mit.edu	37	2	136473266	136473266	+	Splice_Site	SNP	T	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr2:136473266T>A	uc002tuo.3	+	23	3146	c.2776_splice	c.e23+2	p.G926_splice	R3HDM1_uc010fni.3_Splice_Site_p.G925_splice|R3HDM1_uc002tup.3_Splice_Site_p.G871_splice|R3HDM1_uc010zbh.2_Splice_Site_p.G674_splice	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	Homo sapiens R3H domain containing 1 (R3HDM1), mRNA.	926							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		CCGGGCAAGGTAAGTGCACAT	0.443000														75			7		0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51757967	51757967	+	Silent	SNP	G	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr12:51757967G>A	uc001ryk.2	-	4	1212	c.987C>T	c.(985-987)ttC>ttT	p.F329F	GALNT6_uc009zma.1_Non-coding_Transcript|GALNT6_uc001ryl.1_Silent_p.F329F	NM_007210	NP_009141	Q8NCL4	GALT6_HUMAN	Homo sapiens UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6), mRNA.	329					protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTTCCCAGCCGAAGGTCAGGC	0.572000														130			4		0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82579951	82579951	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr7:82579951T>C	uc003uhx.2	-	5	10242	c.9953A>G	c.(9952-9954)tAt>tGt	p.Y3318C	PCLO_uc003uhv.2_Missense_Mutation_p.Y3318C|PCLO_uc010lec.3_Missense_Mutation_p.Y283C	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 1, mRNA.	3249					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTCATAGTTATACTGGTAGAT	0.483000														117			6		0	0	1	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033159	41033159	+	Missense_Mutation	SNP	G	A	A	rs144752439		TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr21:41033159G>A	uc021wjj.1	+	0	673	c.673G>A	c.(673-675)Gtg>Atg	p.V225M	B3GALT5_uc002yyb.1_Missense_Mutation_p.V225M|B3GALT5_uc002yye.2_Missense_Mutation_p.V225M|B3GALT5_uc002yyi.1_Missense_Mutation_p.V225M|B3GALT5_uc002yyj.1_Missense_Mutation_p.V225M|B3GALT5_uc002yyk.1_Missense_Mutation_p.V225M|B3GALT5_uc002yyl.1_Missense_Mutation_p.V225M|B3GALT5_uc002yym.1_Missense_Mutation_p.V225M	NM_033173	NP_149363	Q9Y2C3	B3GT5_HUMAN	Homo sapiens UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (B3GALT5), transcript variant 5, mRNA.	225					protein glycosylation	Golgi membrane|endoplasmic reticulum|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				TTCTGGCGACGTGGCGAGTCA	0.522000														40			11		0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100087171	100087171	+	Silent	SNP	C	A	A	rs141655359	byFrequency	TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr7:100087171C>A	uc003uvd.1	+	3	1986	c.1827C>A	c.(1825-1827)atC>atA	p.I609I	NYAP1_uc003uve.1_Silent_p.I391I	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	Homo sapiens neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 (NYAP1), mRNA.	609								p.I609I(1)									CCCACGTCATCGCCAGCGCAG	0.642000														32			13		3.41278e-10	3.58342e-10	1	1	0
ARC	23237	broad.mit.edu	37	8	143694490	143694490	+	Silent	SNP	G	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr8:143694490G>A	uc022bca.1	-	0	1143	c.1143C>T	c.(1141-1143)ccC>ccT	p.P381P	ARC_uc003ywn.1_Silent_p.P381P	NM_015193	NP_056008	Q7LC44	ARC_HUMAN	Homo sapiens activity-regulated cytoskeleton-associated protein (ARC), mRNA.	381					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	13	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				TGTTGGGGGCGGGCGTGAGGG	0.706000														16			20		0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420144	56420144	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr2:56420144G>A	uc002rzn.3	+	1	1311	c.809G>A	c.(808-810)cGc>cAc	p.R270H	CCDC85A_uc021vhw.1_Intron	NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	Homo sapiens coiled-coil domain containing 85A (CCDC85A), mRNA.	270	His-rich.									breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACCCCAGATCGCCCCAAAGCA	0.652000														64			7		0	0	1	0	0
ZBTB33	10009	broad.mit.edu	37	X	119389135	119389135	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chrX:119389135G>A	uc022cdm.1	+	0	1865	c.1865G>A	c.(1864-1866)gGa>gAa	p.G622E	ZBTB33_uc010nqm.1_Missense_Mutation_p.G622E|ZBTB33_uc004esn.1_Missense_Mutation_p.G622E	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	Homo sapiens zinc finger and BTB domain containing 33 (ZBTB33), transcript variant 2, mRNA.	622	Interaction with CTNND1 (By similarity).|Required for DNA-binding (By similarity).				Wnt receptor signaling pathway|intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	26						GTTGACACTGGAAAAGAACCT	0.378000														128			6		0	0	1	0	0
BCAS3	54828	broad.mit.edu	37	17	59118255	59118255	+	Splice_Site	SNP	T	G	G			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr17:59118255T>G	uc002iyv.4	+	20	2183	c.2074_splice	c.e20+2	p.L692_splice	BCAS3_uc002iyu.4_Splice_Site_p.L677_splice|BCAS3_uc002iyw.4_Splice_Site_p.L673_splice|BCAS3_uc002iyy.4_Splice_Site_p.L448_splice|BCAS3_uc002iyz.4_Splice_Site_p.L246_splice|BCAS3_uc002iza.4_Splice_Site_p.L231_splice	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	Homo sapiens breast carcinoma amplified sequence 3 (BCAS3), transcript variant 1, mRNA.	692						nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			TTGCTGGCCGTAAGTAGTTCA	0.428000														6			21		0	0	1	0	0
NKAP	79576	broad.mit.edu	37	X	119072773	119072773	+	Splice_Site	SNP	C	T	T			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chrX:119072773C>T	uc004esh.3	-	2	554	c.387_splice	c.e2-1	p.K129_splice	NKAP_uc004esg.3_5'Flank	NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	Homo sapiens NFKB activating protein (NKAP), mRNA.	129					Notch signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						CACTTAATCTCCTAGCAGATA	0.348000														158			4		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118347	118347	+	RNA	SNP	A	G	G			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chrGL000205.1:118347A>G	uc002kgk.4	+	0		c.1725A>G								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GGACTTCTGCAGCCAGGGAAG	0.542000														11			7		0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165987817	165987817	+	Silent	SNP	G	T	T			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr2:165987817G>T	uc002ucx.3	-	15	2994	c.2502C>A	c.(2500-2502)ctC>ctA	p.L834L	SCN3A_uc002ucy.3_Silent_p.L785L|SCN3A_uc002ucz.3_Silent_p.L785L|SCN3A_uc002uda.1_Silent_p.L654L|SCN3A_uc002udb.1_Silent_p.L654L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	Homo sapiens sodium channel, voltage-gated, type III, alpha subunit (SCN3A), transcript variant 1, mRNA.	834						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CCATTAAACTGAGGCTGACAA	0.403000														171			10		1.58986e-06	1.58986e-06	1	1	0
WFDC5	149708	broad.mit.edu	37	20	43739299	43739299	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr20:43739299C>T	uc002xne.2	-	1	292	c.203G>A	c.(202-204)cGc>cAc	p.R68H		NM_145652	NP_663627	Q8TCV5	WFDC5_HUMAN	Homo sapiens WAP four-disulfide core domain 5 (WFDC5), mRNA.	68	WAP 1.					extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GACACACTGGCGGAAGCAAGC	0.622000														33			22		0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8521528	8521528	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr9:8521528C>G	uc003zkk.3	-	19	1453	c.710G>C	c.(709-711)aGa>aCa	p.R237T	PTPRD_uc003zkp.3_Missense_Mutation_p.R237T|PTPRD_uc003zkq.3_Missense_Mutation_p.R237T|PTPRD_uc003zkr.3_Missense_Mutation_p.R231T|PTPRD_uc003zks.3_Missense_Mutation_p.R227T|PTPRD_uc022bdj.1_Missense_Mutation_p.R234T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 1, mRNA.	237	Ig-like C2-type 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.P236Q(1)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GATAGAGAATCTTGGTGGGAC	0.448000										TSP Lung(15;0.13)				80			5		0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37483813	37483813	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr2:37483813delG	uc002rqd.3	-	15	2960	c.2405delC	c.(2404-2406)tctfs	p.S802fs	PRKD3_uc002rqe.1_Frame_Shift_Del_p.S402fs	NM_005813	NP_005804	O94806	KPCD3_HUMAN	Homo sapiens protein kinase D3 (PRKD3), mRNA.	802	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				ACCTTCACCAGAAATTTCTCT	0.323													---	84	---	---	7	---					
EPC2	26122	broad.mit.edu	37	2	149542571	149542572	+	Splice_Site	DEL	GT	-	-			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr2:149542571_149542572delGT	uc010zbt.2	+	13	2378	c.2351_splice	c.e13+1	p.R784_splice		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	Homo sapiens enhancer of polycomb homolog 2 (Drosophila) (EPC2), mRNA.	784					DNA repair|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.0516)		GCATAGCAAGGTGTGTGTGTGT	0.465													---	112	---	---	7	---					
POLR1C	9533	broad.mit.edu	37	6	43497114	43497114	+	Splice_Site	DEL	A	-	-			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr6:43497114delA	uc003ovo.2	+	9	1121	c.1050_splice	c.e9+1		XPO5_uc003ovp.3_Intron	NM_203290	NP_976035	O15160	RPAC1_HUMAN	Homo sapiens polymerase (RNA) I polypeptide C, 30kDa (POLR1C), mRNA.						termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity			kidney(1)|large_intestine(2)|lung(1)|prostate(1)	5	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			ccccgtctctactaaaaaaaa	0.493													---	4	---	---	2	---					
MYC	4609	broad.mit.edu	37	8	128752827	128752827	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr8:128752827delA	uc003ysi.3	+	2	1513	c.988delA	c.(988-990)actfs	p.T330fs		NM_002467	NP_002458	P01106	MYC_HUMAN	Homo sapiens v-myc myelocytomatosis viral oncogene homolog (avian) (MYC), mRNA.	315					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		GCCTCCCTCCACTCGGAAGGA	0.577		3	"""A, T"""	"""IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"""	"""Burkitt lymphoma,  amplified in other cancers, B-CLL"""								---	90	---	---	7	---					
OR4N2	390429	broad.mit.edu	37	14	20296067	20296067	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KN-8421-01A-11D-2310-10	TCGA-KN-8421-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba686386-8113-4885-b20f-6ad09a295604	9d5ee3f8-490f-4865-bb90-fe0a1bbf3643	g.chr14:20296067delG	uc010tkv.2	+	0	460	c.460delG	c.(460-462)gtcfs	p.V154fs		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily N, member 2 (OR4N2), mRNA.	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F153F(1)|p.V154V(1)		breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGGGGTTTTGTCCACTCCAT	0.527													---	198	---	---	7	---					
