Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDC23	8697	broad.mit.edu	37	5	137524673	137524673	+	Silent	SNP	C	T	T			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr5:137524673C>T	uc003lcl.3	-	15	1819	c.1788G>A	c.(1786-1788)acG>acA	p.T596T		NM_004661	NP_004652	Q9UJX2	CDC23_HUMAN	Homo sapiens cell division cycle 23 homolog (S. cerevisiae) (CDC23), mRNA.	596					G1 phase of mitotic cell cycle|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(6)|prostate(2)|skin(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CCAACTATGGCGTGACAGAAG	0.493000														72			3		0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17321179	17321179	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr19:17321179A>G	uc010eak.3	+	36	5938	c.5786A>G	c.(5785-5787)gAg>gGg	p.E1929G	MYO9B_uc002nfi.3_Missense_Mutation_p.E1929G|MYO9B_uc002nfj.1_Intron|MYO9B_uc002nfm.1_Missense_Mutation_p.E89G	NM_004145	NP_004136	Q13459	MYO9B_HUMAN	Homo sapiens myosin IXB (MYO9B), transcript variant 1, mRNA.	1929	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	ADP binding|ATP binding|ATPase activity|Rho GTPase activator activity|actin binding|calmodulin binding|metal ion binding|microfilament motor activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						TCTCCCTATGAGGGGGTCCTG	0.632000														49			4		0	0	1	0	0
PEAR1	375033	broad.mit.edu	37	1	156877478	156877478	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr1:156877478T>C	uc001fqj.1	+	6	837	c.721T>C	c.(721-723)Ttc>Ctc	p.F241L	PEAR1_uc009wsl.1_Missense_Mutation_p.F42L|PEAR1_uc001fqk.1_5'UTR	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	Homo sapiens platelet endothelial aggregation receptor 1 (PEAR1), mRNA.	241	EGF-like 2.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGAGGTGTCTTCCAAACCCC	0.617000														77			4		0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52909852	52909852	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr19:52909852C>T	uc002pzh.3	+	5	653	c.227C>T	c.(226-228)gCa>gTa	p.A76V	ZNF528_uc002pzi.3_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	Homo sapiens zinc finger protein 528 (ZNF528), mRNA.	76	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GAGAAAATAGCAAACGATCCA	0.463000														47			18		0	0	1	0	0
NDST4	64579	broad.mit.edu	37	4	115767025	115767025	+	Missense_Mutation	SNP	A	T	T			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr4:115767025A>T	uc003ibu.3	-	9	2748	c.2069T>A	c.(2068-2070)aTc>aAc	p.I690N	NDST4_uc010imw.3_Non-coding_Transcript	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	Homo sapiens N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 (NDST4), mRNA.	690	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GAGGATGGTGATGATCTTGGC	0.428000														100			14		0	0	1	0	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	136821	136821	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chrGL000209.1:136821G>A	uc002quo.2	+	3	627	c.608G>A	c.(607-609)cGt>cAt	p.R203H	KIR2DL2_uc021vdc.1_Missense_Mutation_p.R203H|KIR2DL2_uc021vdd.1_Missense_Mutation_p.R203H|KIR2DL2_uc010evk.1_Missense_Mutation_p.R103H|KIR2DL2_uc010evl.1_Intron|KIR2DL2_uc002qun.2_Missense_Mutation_p.R203H	NM_012312	NP_036444	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 2 (KIR2DS2), mRNA.	203	Ig-like C2-type 2.				regulation of immune response	integral to membrane|plasma membrane	receptor activity										GGCTCTTTCCGTGACTCTCCC	0.547000														6			3		0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89421805	89421805	+	Missense_Mutation	SNP	G	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr11:89421805G>C	uc001pda.3	+	9	1188	c.662G>C	c.(661-663)gGa>gCa	p.G221A		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	Homo sapiens folate hydrolase 1B (FOLH1B), mRNA.	221					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						CAACGACTTGGAATTGCTTCA	0.299000														240			149		0	0	1	0	0
BHLHE40	8553	broad.mit.edu	37	3	5025274	5025274	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr3:5025274A>C	uc003bqf.3	+	4	1443	c.1136A>C	c.(1135-1137)cAg>cCg	p.Q379P	BHLHE40_uc011asw.2_Missense_Mutation_p.Q239P	NM_003670	NP_003661	O14503	BHE40_HUMAN	Homo sapiens basic helix-loop-helix family, member e40 (BHLHE40), mRNA.	379						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(2)	12						CTCATGCCCCAGAGACTCCCT	0.557000														60			12		0	0	1	0	0
FAM9A	171482	broad.mit.edu	37	X	8767124	8767124	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chrX:8767124C>T	uc022bsk.1	-	2	239	c.103G>A	c.(103-105)Gcc>Acc	p.A35T	FAM9A_uc004csg.3_Missense_Mutation_p.A35T	NM_001171186	NP_777611	Q8IZU1	FAM9A_HUMAN	Homo sapiens family with sequence similarity 9, member A (FAM9A), transcript variant 1, mRNA.	35						nucleolus				endometrium(11)|kidney(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	18		Hepatocellular(5;0.219)				AAGTTAGAGGCGATCCCTGAA	0.542000														113			4		0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7477054	7477054	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr7:7477054T>C	uc003src.1	-	21	1879	c.1762A>G	c.(1762-1764)Aca>Gca	p.T588A	COL28A1_uc011jxe.1_Missense_Mutation_p.T271A|COL28A1_uc003srd.3_Missense_Mutation_p.T143A|COL28A1_uc003sre.1_Missense_Mutation_p.T9A	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	Homo sapiens collagen, type XXVIII, alpha 1 (COL28A1), mRNA.	588					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGAATTGATGTTCCAGGCATT	0.398000														43			4		0	0	1	0	0
MAST1	22983	broad.mit.edu	37	19	12985463	12985463	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr19:12985463C>A	uc002mvm.3	+	25	4620	c.4492C>A	c.(4492-4494)Ccc>Acc	p.P1498T		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	Homo sapiens microtubule associated serine/threonine kinase 1 (MAST1), mRNA.	1498					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						TCGCTCCAAGCCCGCCTCCCC	0.721000														22			14		6.49762e-13	6.49762e-13	1	1	0
SDAD1	55153	broad.mit.edu	37	4	76896979	76896979	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr4:76896979A>G	uc003hje.4	-	5	615	c.496T>C	c.(496-498)Tac>Cac	p.Y166H	SDAD1_uc003hjf.4_Missense_Mutation_p.Y69H|SDAD1_uc011cbr.2_Missense_Mutation_p.Y129H	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	Homo sapiens SDA1 domain containing 1 (SDAD1), mRNA.	166					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			AACATGGTGTACATGAAATTT	0.378000														210			4		0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576392	158576392	+	Missense_Mutation	SNP	T	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr1:158576392T>A	uc010pio.2	+	0	164	c.164T>A	c.(163-165)cTg>cAg	p.L55Q		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily Z, member 1 (OR10Z1), mRNA.	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					GATAGCCATCTGCACACCCCC	0.512000														116			28		0	0	1	0	0
MLL2	8085	broad.mit.edu	37	12	49432249	49432249	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr12:49432249C>A	uc001rta.4	-	33	8890	c.8890G>T	c.(8890-8892)Gtc>Ttc	p.V2964F		NM_003482	NP_003473	O14686	MLL2_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2), mRNA.	2964	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(38)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(121)|kidney(35)|large_intestine(22)|lung(78)|ovary(3)|pancreas(2)|prostate(13)|skin(7)|stomach(3)|upper_aerodigestive_tract(9)|urinary_tract(5)	366						GGCCGGTTGACCAGCTCCAAA	0.607000			"""N, F, Mis"""		"""medulloblastoma, renal"""					HNSCC(34;0.089)				65			20		5.60225e-13	5.84583e-13	1	1	0
ORM1	5004	broad.mit.edu	37	9	117088629	117088629	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr9:117088629G>A	uc004bik.4	+	5	709	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	ORM1_uc011lxo.2_Intron	NM_000607	NP_000598	P02763	A1AG1_HUMAN	Homo sapiens orosomucoid 1 (ORM1), mRNA.	200					acute-phase response|regulation of immune system process|transport	extracellular space	protein binding			endometrium(2)|large_intestine(4)|lung(2)	8		Myeloproliferative disorder(63;0.163)			Acenocoumarol(DB01418)|Alfentanil(DB00802)|Aprindine(DB01429)|Disopyramide(DB00280)|Penbutolol(DB01359)|Phenprocoumon(DB00946)|Quinidine(DB00908)|Tamsulosin(DB00706)	GGAGGAGGGGGAATCCTAGCA	0.567000														138			5		0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26919762	26919762	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr17:26919762T>C	uc002hbq.3	-	2	592	c.500A>G	c.(499-501)gAc>gGc	p.D167G	SPAG5_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	Homo sapiens sperm associated antigen 5 (SPAG5), mRNA.	167					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					CACCAGATCGTCTGTTCTCAA	0.478000														88			5		0	0	1	0	0
CPT2	1376	broad.mit.edu	37	1	53676357	53676357	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr1:53676357C>G	uc001cvb.4	+	3	1526	c.1011C>G	c.(1009-1011)caC>caG	p.H337Q		NM_000098	NP_000089	P23786	CPT2_HUMAN	Homo sapiens carnitine palmitoyltransferase 2 (CPT2), nuclear gene encoding mitochondrial protein, mRNA.	337					carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	15					L-Carnitine(DB00583)|Perhexiline(DB01074)	ACCTTGTCCACTTGTCCCACA	0.498000														66			26		0	0	1	0	0
MPHOSPH8	54737	broad.mit.edu	37	13	20220943	20220943	+	Missense_Mutation	SNP	G	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr13:20220943G>C	uc001umh.3	+	2	831	c.730G>C	c.(730-732)Gaa>Caa	p.E244Q	MPHOSPH8_uc001umg.3_Missense_Mutation_p.E244Q|MPHOSPH8_uc001umi.3_5'UTR	NM_017520	NP_059990	Q99549	MPP8_HUMAN	Homo sapiens M-phase phosphoprotein 8 (MPHOSPH8), mRNA.	244	Lys-rich.				cell cycle	cytoplasm|nucleus				breast(2)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		gaaaacaagagaagatcccaa	0.313000														28			14		0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25203089	25203089	+	Silent	SNP	C	T	T			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr8:25203089C>T	uc003xeg.3	+	25	2853	c.2716C>T	c.(2716-2718)Ctg>Ttg	p.L906L	DOCK5_uc010luf.1_Non-coding_Transcript|DOCK5_uc003xeh.1_Silent_p.L620L|DOCK5_uc003xei.3_Silent_p.L476L|DOCK5_uc003xej.3_Non-coding_Transcript	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	Homo sapiens dedicator of cytokinesis 5 (DOCK5), mRNA.	906						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		CTCGCAGCTTCTGAGCAACAT	0.552000														56			3		0	0	1	0	0
LOC100125556	100125556	broad.mit.edu	37	3	125647387	125647387	+	RNA	SNP	G	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr3:125647387G>A	uc003eid.4	+	4		c.463G>A			LOC100125556_uc003eif.4_Non-coding_Transcript					Homo sapiens family with sequence similarity 86, member A pseudogene (LOC100125556), transcript variant 2, non-coding RNA.																		ACCAGAAACTGTTTCCCTATG	0.502000														82			4		0	0	1	0	0
MFSD6	54842	broad.mit.edu	37	2	191364759	191364759	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr2:191364759G>A	uc002urz.2	+	7	2515	c.2191G>A	c.(2191-2193)Gaa>Aaa	p.E731K	MFSD6_uc010zge.1_Missense_Mutation_p.E193K	NM_017694	NP_060164	Q6ZSS7	MFSD6_HUMAN	Homo sapiens major facilitator superfamily domain containing 6 (MFSD6), mRNA.	731					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(3)|stomach(1)	23						TGAGAATAGGGAAAATTCTCC	0.468000														110			6		0	0	1	0	0
RGMA	56963	broad.mit.edu	37	15	93588500	93588500	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr15:93588500C>T	uc010urc.2	-	3	1336	c.1105G>A	c.(1105-1107)Gtg>Atg	p.V369M	RGMA_uc002bsq.2_Missense_Mutation_p.V345M|RGMA_uc021svs.1_Missense_Mutation_p.V345M|RGMA_uc021svt.1_Missense_Mutation_p.V345M|RGMA_uc010boi.2_Missense_Mutation_p.V252M|RGMA_uc002bsr.2_Missense_Mutation_p.V252M|RGMA_uc021svu.1_Missense_Mutation_p.V345M|RGMA_uc002bss.2_Missense_Mutation_p.V361M	NM_001166283	NP_001159761	Q96B86	RGMA_HUMAN	Homo sapiens RGM domain family, member A (RGMA), transcript variant 1, mRNA.	361					axon guidance	anchored to membrane|endoplasmic reticulum|plasma membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	9	Lung NSC(78;0.0542)|all_lung(78;0.0786)		BRCA - Breast invasive adenocarcinoma(143;0.0312)|OV - Ovarian serous cystadenocarcinoma(32;0.108)			CACTTGGCCACGGCTGTCTCG	0.667000														26			3		0	0	1	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52149193	52149193	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr19:52149193G>A	uc002pxf.4	-	2	662	c.542C>T	c.(541-543)aCg>aTg	p.T181M		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	Homo sapiens sialic acid binding Ig-like lectin 14 (SIGLEC14), mRNA.	181	Ig-like C2-type 1.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding	p.T181M(3)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		GGCATTCCCCGTCCAGGAGAA	0.657000														123			26		0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150432553	150432553	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr1:150432553A>G	uc009wlr.3	+	8	1372	c.1171A>G	c.(1171-1173)Aaa>Gaa	p.K391E	RPRD2_uc010pcc.1_Missense_Mutation_p.K365E|RPRD2_uc001eup.4_Missense_Mutation_p.K365E	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Homo sapiens regulation of nuclear pre-mRNA domain containing 2 (RPRD2), mRNA.	391							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CAGGAAGGAAAAACCTGCAGA	0.403000														69			4		0	0	1	0	0
ACBD3	64746	broad.mit.edu	37	1	226349254	226349255	+	In_Frame_Ins	INS	-	TTC	TTC			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr1:226349254_226349255insTTC	uc001hpy.3	-	3	752_753	c.705_706insGAA	c.(703-708)insGAA	p.235_236insE		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	Homo sapiens acyl-CoA binding domain containing 3 (ACBD3), mRNA.	235	Arg-rich.|Glu-rich.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding			breast(2)|endometrium(3)|large_intestine(5)|lung(7)|skin(1)|urinary_tract(2)	20	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		AACCGAAGcctttcttcttcta	0.396													---	76	---	---	22	---					
ABCE1	6059	broad.mit.edu	37	4	146041093	146041093	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr4:146041093delT	uc003ijx.3	+	10	1372	c.932delT	c.(931-933)attfs	p.I311fs	ABCE1_uc003ijy.3_Frame_Shift_Del_p.I311fs|ABCE1_uc010iot.3_Non-coding_Transcript	NM_001040876	NP_002931	P61221	ABCE1_HUMAN	Homo sapiens ATP-binding cassette, sub-family E (OABP), member 1 (ABCE1), transcript variant 2, mRNA.	311	ABC transporter 1.				RNA catabolic process|interspecies interaction between organisms|response to virus	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|lung(5)|prostate(2)|skin(3)	18	all_hematologic(180;0.151)					GGCATAAACATTTTTTTGGAT	0.358													---	368	---	---	7	---					
LAMB4	22798	broad.mit.edu	37	7	107763584	107763584	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr7:107763584delA	uc010ljo.1	-	1	110	c.26delT	c.(25-27)ttgfs	p.L9fs	LAMB4_uc003vey.2_Frame_Shift_Del_p.L9fs	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	Homo sapiens laminin, beta 4 (LAMB4), mRNA.	9					cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						ACCAAGGTGCAAAAAAAGGGT	0.308													---	128	---	---	7	---					
PGR	5241	broad.mit.edu	37	11	100999089	100999089	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr11:100999089delT	uc001pgh.2	-	0	1456	c.713delA	c.(712-714)aagfs	p.K238fs	PGR_uc001pgi.2_Frame_Shift_Del_p.K238fs|PGR_uc009yww.1_Non-coding_Transcript|PGR_uc001pgj.2_Non-coding_Transcript|PGR_uc009ywx.1_Non-coding_Transcript|FJ515873_uc010rum.2_5'Flank	NM_000926	NP_000917	P06401	PRGR_HUMAN	Homo sapiens progesterone receptor (PGR), transcript variant 2, mRNA.	238	Modulating, Pro-Rich.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	36		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	AGGTTTGCCCTTCAGAAGCGG	0.721													---	4	---	---	2	---					
SRP14	6727	broad.mit.edu	37	15	40328594	40328595	+	In_Frame_Ins	INS	-	GGG	GGG			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr15:40328594_40328595insGGG	uc001zkq.2	-	4	422_423	c.350_351insCCC	c.(349-351)cct>ccCCCt	p.117_117P>PP	SRP14_uc001zkr.2_3'UTR|LOC100131089_uc021sjc.1_5'Flank|LOC100131089_uc021sjd.1_5'Flank|LOC100131089_uc021sje.1_5'Flank|LOC100131089_uc001zks.2_5'Flank	NM_003134	NP_003125	P37108	SRP14_HUMAN	Homo sapiens signal recognition particle 14kDa (homologous Alu RNA binding protein) (SRP14), mRNA.	117	Ala/Thr-rich.				SRP-dependent cotranslational protein targeting to membrane|negative regulation of translational elongation|response to drug	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		ctgctgcggcaggtgctgctgc	0.480													---	113	---	---	7	---					
SRRM2	23524	broad.mit.edu	37	16	2818052	2818053	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr16:2818052_2818053insC	uc002crk.3	+	10	8072_8073	c.7523_7524insC	c.(7522-7524)gagfs	p.E2508fs	SRRM2_uc002crj.1_Frame_Shift_Ins_p.E2412fs|SRRM2_uc002crl.1_Frame_Shift_Ins_p.E2508fs|SRRM2_uc010bsu.1_Frame_Shift_Ins_p.E2412fs	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	Homo sapiens serine/arginine repetitive matrix 2 (SRRM2), mRNA.	2508	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|RNA binding|protein N-terminus binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GATGTGGGGGAGCCACCTGCCT	0.639													---	128	---	---	7	---					
CDH13	1012	broad.mit.edu	37	16	83636109	83636110	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chr16:83636109_83636110insG	uc010vns.2	+	8	1416_1417	c.1152_1153insG	c.(1150-1155)gctggafs	p.A384fs	CDH13_uc002fgx.3_Frame_Shift_Ins_p.A337fs|CDH13_uc010vnt.2_Frame_Shift_Ins_p.A83fs|CDH13_uc010vnu.2_Frame_Shift_Ins_p.A298fs	NM_001220488	NP_001207417	P55290	CAD13_HUMAN	Homo sapiens cadherin 13, H-cadherin (heart) (CDH13), transcript variant 2, mRNA.	337	Cadherin 3.				Rac protein signal transduction|Rho protein signal transduction|adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		AAGATATGGCTGGACTGGATGT	0.421													---	182	---	---	8	---					
FAM122B	159090	broad.mit.edu	37	X	133930385	133930386	+	Splice_Site	INS	-	C	C			TCGA-KN-8422-01A-11D-2310-10	TCGA-KN-8422-11A-01D-2310-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d648c804-4eaf-4252-8b6f-13378158a07d	e13915df-0ba2-4242-b4f7-27733b6a01c1	g.chrX:133930385_133930386insC	uc022cem.1	-	1	1	c.-149_splice	c.e1-1		FAM122C_uc010nru.2_5'Flank|FAM122B_uc004ext.3_5'Flank|FAM122B_uc004exq.3_Splice_Site|FAM122B_uc022cek.1_Splice_Site|FAM122B_uc022cel.1_5'UTR|FAM122B_uc004exr.3_5'UTR|FAM122B_uc011mvp.2_Intron|FAM122B_uc004exv.3_Splice_Site	NM_001170756	NP_001164227	Q7Z309	F122B_HUMAN	Homo sapiens family with sequence similarity 122B (FAM122B), transcript variant 4, mRNA.											breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|skin(1)	6	Acute lymphoblastic leukemia(192;0.000127)					gggggcgggggctgggggcgga	0.639													---	4	---	---	2	---					
