Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NIPA2	81614	broad.mit.edu	37	15	23006232	23006232	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr15:23006232T>C	uc001yvb.3	-	9	1929	c.1072A>G	c.(1072-1074)Aca>Gca	p.T358A	NIPA2_uc001yux.3_Missense_Mutation_p.T358A|NIPA2_uc001yuy.3_Missense_Mutation_p.T358A|NIPA2_uc001yuz.3_Missense_Mutation_p.T358A|NIPA2_uc010ayb.3_Missense_Mutation_p.T339A|NIPA2_uc001yva.3_Missense_Mutation_p.T339A	NM_001184889	NP_112184	Q8N8Q9	NIPA2_HUMAN	Homo sapiens non imprinted in Prader-Willi/Angelman syndrome 2 (NIPA2), transcript variant 5, mRNA.	358						early endosome|integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(4)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		TAAAAAGCTGTCAGATTTCCA	0.318000														93			4		0	0	1	0	0
CCT6P3	643180	broad.mit.edu	37	7	64530103	64530103	+	RNA	SNP	G	A	A	rs137873032	by1000genomes	TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr7:64530103G>A	uc003ttt.1	+	6		c.929G>A			CCT6P3_uc010kzt.1_Non-coding_Transcript					Homo sapiens chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3 (CCT6P3), non-coding RNA.																		TGACTGCTTGGGACATGCAGG	0.388000														67			4		0	0	1	0	0
ITGB1	3688	broad.mit.edu	37	10	33218830	33218830	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr10:33218830C>T	uc001iws.4	-	3	432	c.296G>A	c.(295-297)aGc>aAc	p.S99N	ITGB1_uc001iwr.4_Missense_Mutation_p.S99N|ITGB1_uc001iwt.4_Missense_Mutation_p.S99N	NM_133376	NP_596867	P05556	ITB1_HUMAN	Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (ITGB1), transcript variant 1E, mRNA.	99					axon guidance|blood coagulation|cell-cell adhesion mediated by integrin|cell-matrix adhesion|cellular defense response|homophilic cell adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|leukocyte migration|positive regulation of apoptosis|regulation of immune response	cell surface|cleavage furrow|focal adhesion|melanosome|neuromuscular junction|ruffle|sarcolemma	identical protein binding|protein heterodimerization activity|receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Ovarian(717;1.34e-05)|Breast(68;0.0634)				TGTTCCTTTGCTACGGTTGGT	0.413000														22			63		0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71925084	71925084	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chrX:71925084T>C	uc004eax.4	-	2	549	c.248A>G	c.(247-249)aAg>aGg	p.K83R	PHKA1_uc004eay.4_Missense_Mutation_p.K83R|PHKA1_uc011mqi.2_Missense_Mutation_p.K83R	NM_002637	NP_002628	P46020	KPB1_HUMAN	Homo sapiens phosphorylase kinase, alpha 1 (muscle) (PHKA1), transcript variant 1, mRNA.	83					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					TCTCATCAGCTTCACTACACT	0.393000														202			5		0	0	1	0	0
GALNS	2588	broad.mit.edu	37	16	88889069	88889069	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr16:88889069T>C	uc010cid.3	-	12	1551	c.1310A>G	c.(1309-1311)aAt>aGt	p.N437S	GALNS_uc002fly.4_Missense_Mutation_p.N431S|GALNS_uc002flz.4_Missense_Mutation_p.N114S			P34059	GALNS_HUMAN	Homo sapiens galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS), mRNA.	431						lysosome	N-acetylgalactosamine-4-sulfatase activity|N-acetylgalactosamine-6-sulfatase activity|metal ion binding	p.T436T(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(8)	22				BRCA - Breast invasive adenocarcinoma(80;0.0496)	Hyaluronidase(DB00070)	GTCTTCCAGATTGTGAGTTGT	0.617000														58			38		0	0	1	0	0
RIPPLY2	134701	broad.mit.edu	37	6	84567032	84567032	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr6:84567032C>A	uc003pke.3	+	3	462	c.311C>A	c.(310-312)cCa>cAa	p.P104Q	CYB5R4_uc003pkf.3_5'Flank	NM_001009994	NP_001009994	Q5TAB7	RIPP2_HUMAN	Homo sapiens ripply2 homolog (zebrafish) (RIPPLY2), mRNA.	104	Ripply homology domain.				somite rostral/caudal axis specification	nucleus				large_intestine(2)|lung(4)|urinary_tract(1)	7						AAAAATTTTCCAATTCAAGCC	0.299000														46			5		0.000274275	0.000274275	1	1	0
HBP1	26959	broad.mit.edu	37	7	106827076	106827076	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr7:106827076A>G	uc003vdy.3	+	5	901	c.715A>G	c.(715-717)Aga>Gga	p.R239G	HBP1_uc011klv.2_Missense_Mutation_p.R249G|HBP1_uc003vdz.3_Missense_Mutation_p.R239G|HBP1_uc003vea.3_Missense_Mutation_p.R239G|HBP1_uc003veb.1_Missense_Mutation_p.R239G	NM_012257	NP_036389	O60381	HBP1_HUMAN	Homo sapiens HMG-box transcription factor 1 (HBP1), transcript variant 2, mRNA.	239	AXH.				Wnt receptor signaling pathway|cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						AGATTTTGCTAGAGCTGAAGG	0.358000														171			4		0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8966765	8966765	+	Silent	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr19:8966765C>T	uc002mkp.3	-	80	43392	c.43188G>A	c.(43186-43188)tcG>tcA	p.S14396S	MUC16_uc010dwi.3_Non-coding_Transcript|MUC16_uc010dwj.3_Silent_p.S1196S|MUC16_uc021uog.1_Non-coding_Transcript	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	14494				Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAGCCAGTGGCGAGAAGTTAC	0.527000														52			16		0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153588714	153588714	+	Missense_Mutation	SNP	A	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chrX:153588714A>T	uc004fkk.2	-	21	3698	c.3449T>A	c.(3448-3450)tTc>tAc	p.F1150Y	FLNA_uc011mzn.1_5'Flank|FLNA_uc010nuu.1_Missense_Mutation_p.F1150Y	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	Homo sapiens filamin A, alpha (FLNA), transcript variant 2, mRNA.	1150					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	Fc-gamma receptor I complex binding|GTP-Ral binding|Rac GTPase binding|actin filament binding|glycoprotein binding|protein homodimerization activity|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTGGGCCTTGAATGGGGAGCC	0.617000											OREG0003593	type=REGULATORY REGION|Gene=FLNA|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay		19			87		0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29759270	29759270	+	Silent	SNP	G	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr10:29759270G>A	uc001iut.1	-	31	6531	c.5778C>T	c.(5776-5778)caC>caT	p.H1926H	LOC387647_uc001iup.3_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Silent_p.H840H|SVIL_uc001iuu.1_Silent_p.H1500H	NM_021738	NP_068506	O95425	SVIL_HUMAN	Homo sapiens supervillin (SVIL), transcript variant 2, mRNA.	1926					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CTTTGCATCCGTGCCACAGGT	0.567000														81			15		0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64468715	64468715	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr5:64468715G>A	uc003jtp.3	-	22	3845	c.3031C>T	c.(3031-3033)Cgc>Tgc	p.R1011C	ADAMTS6_uc003jto.3_Non-coding_Transcript|ADAMTS6_uc003jtq.3_Non-coding_Transcript	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 6 (ADAMTS6), mRNA.	1011					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.R1011C(1)|p.R182C(1)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AAACTGCAGCGGATGCGGACA	0.552000														49			34		0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167656152	167656152	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr4:167656152C>T	uc011cjq.1	-	9	1315	c.1258G>A	c.(1258-1260)Gat>Aat	p.D420N	SPOCK3_uc021xuf.1_Missense_Mutation_p.D411N|SPOCK3_uc011cjr.1_Missense_Mutation_p.D291N|SPOCK3_uc003iri.1_Missense_Mutation_p.D411N|SPOCK3_uc011cjs.1_Missense_Mutation_p.D360N|SPOCK3_uc003irj.1_Missense_Mutation_p.D408N|SPOCK3_uc011cjt.1_Missense_Mutation_p.D319N|SPOCK3_uc011cjp.2_Missense_Mutation_p.D368N|SPOCK3_uc011cju.1_Missense_Mutation_p.D315N|SPOCK3_uc011cjv.1_Missense_Mutation_p.D313N	NM_001204353	NP_001191282	Q9BQ16	TICN3_HUMAN	Homo sapiens sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 (SPOCK3), transcript variant 4, mRNA.	411	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		tcatcttcatcattcataata	0.358000														599			19		0	0	1	0	0
PIBF1	10464	broad.mit.edu	37	13	73572977	73572977	+	Silent	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr13:73572977A>G	uc001vjc.3	+	16	2372	c.2067A>G	c.(2065-2067)aaA>aaG	p.K689K	PIBF1_uc010aep.3_Silent_p.K148K	NM_006346	NP_006337	Q8WXW3	PIBF1_HUMAN	Homo sapiens progesterone immunomodulatory binding factor 1 (PIBF1), mRNA.	689						centrosome				breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	24		Prostate(6;0.00191)|Breast(118;0.0736)|Acute lymphoblastic leukemia(28;0.0865)		GBM - Glioblastoma multiforme(99;0.000664)		CAGCAATGAAACAGATTCTCG	0.303000														182			5		0	0	1	0	0
ARAP1	116985	broad.mit.edu	37	11	72438103	72438103	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr11:72438103G>A	uc001osu.3	-	2	260	c.71C>T	c.(70-72)aCg>aTg	p.T24M	ARAP1_uc001osv.3_Missense_Mutation_p.T24M	NM_001040118	NP_056057	Q96P48	ARAP1_HUMAN	Homo sapiens ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (ARAP1), transcript variant 3, mRNA.	24	SAM.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	Golgi cisterna membrane|cytosol|plasma membrane	ARF GTPase activator activity|Rho GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						AAAGAGCCCCGTGTACTGCTC	0.657000														50			6		0	0	1	0	0
FOXI3	344167	broad.mit.edu	37	2	88747871	88747871	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr2:88747871C>T	uc010ytq.1	-	2	1115	c.1115G>A	c.(1114-1116)aGc>aAc	p.S372N		NM_001135649	NP_001129121	A8MTJ6	FOXI3_HUMAN	Homo sapiens forkhead box I3 (FOXI3), mRNA.	373	Ser-rich.				epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)	2						GGTGCTATTGCTGGTGCTATT	0.607000														109			4		0	0	1	0	0
DTWD2	285605	broad.mit.edu	37	5	118324112	118324112	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr5:118324112C>A	uc003ksa.3	-	0	129	c.95G>T	c.(94-96)cGg>cTg	p.R32L		NM_173666	NP_775937	Q8NBA8	DTWD2_HUMAN	Homo sapiens DTW domain containing 2 (DTWD2), mRNA.	32										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)	13		all_epithelial(76;0.0982)|Prostate(80;0.121)		OV - Ovarian serous cystadenocarcinoma(64;0.000228)|Epithelial(69;0.000941)|all cancers(49;0.00939)		GCCGCCCTCCCGCCGCTCCTT	0.726000											OREG0016736	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		14			9		2.17888e-05	2.22245e-05	1	1	0
CLEC6A	93978	broad.mit.edu	37	12	8618083	8618083	+	Nonsense_Mutation	SNP	G	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr12:8618083G>A	uc001qum.1	+	3	344	c.227G>A	c.(226-228)tGg>tAg	p.W76*		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	Homo sapiens C-type lectin domain family 6, member A (CLEC6A), mRNA.	76					defense response to fungus|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of cytokine secretion	integral to membrane	sugar binding	p.W76C(1)		breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					AAAATAGCCTGGGGATGTTGC	0.383000														76			68		0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165623	151165623	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr3:151165623T>C	uc011bod.2	-	3	2146	c.2146A>G	c.(2146-2148)Agt>Ggt	p.S716G		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	Homo sapiens immunoglobulin superfamily, member 10 (IGSF10), transcript variant 1, mRNA.	716					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGCCTCTTACTTGTGCTTGAG	0.493000														128			4		0	0	1	0	0
AX746964	0	broad.mit.edu	37	5	140242781	140242781	+	Silent	SNP	G	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr5:140242781G>A	uc003lhy.1	-	0	444	c.195C>T	c.(193-195)agC>agT	p.S65S	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc003lhf.2_Intron|PCDHAC2_uc003lhh.1_Intron|PCDHAC2_uc003lhi.2_Intron|PCDHAC2_uc003lhl.2_Intron|PCDHAC2_uc003lhk.1_Intron|PCDHAC2_uc003lho.2_Intron|PCDHAC2_uc003lhn.2_Intron|PCDHAC2_uc003lhq.2_Intron|PCDHAC2_uc003lhs.2_Intron|PCDHAC2_uc003lhu.2_Intron|PCDHAC2_uc003lhw.2_Intron|PCDHAC2_uc003lhx.2_Intron					SubName: Full=Uncharacterized protein; SubName: Full=cDNA FLJ34090 fis, clone FCBBF3006399;																		TGGTGGCGTCGCTGGCGGAGA	0.672000														19			3		0	0	1	0	0
MYOT	9499	broad.mit.edu	37	5	137221866	137221866	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr5:137221866A>G	uc011cye.2	+	7	1171	c.1154A>G	c.(1153-1155)aAt>aGt	p.N385S	MYOT_uc003lbv.3_Missense_Mutation_p.N385S|MYOT_uc011cyg.2_Missense_Mutation_p.N201S|MYOT_uc011cyh.2_Missense_Mutation_p.N270S	NM_001135940	NP_001129412	Q9UBF9	MYOTI_HUMAN	Homo sapiens myotilin (MYOT), transcript variant 2, mRNA.	385	Ig-like C2-type 2.|Necessary for interaction with ACTA1.|Necessary for interaction with FLNC.				muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGGAAAAGAAATAATGAAATG	0.348000														230			5		0	0	1	0	0
UTP6	55813	broad.mit.edu	37	17	30207665	30207665	+	Silent	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr17:30207665T>C	uc002hgr.3	-	10	977	c.894A>G	c.(892-894)aaA>aaG	p.K298K	UTP6_uc002hgq.3_Silent_p.K114K|UTP6_uc010wbw.1_Silent_p.K298K	NM_018428	NP_060898	Q9NYH9	UTP6_HUMAN	Homo sapiens UTP6, small subunit (SSU) processome component, homolog (yeast) (UTP6), mRNA.	298					rRNA processing	nucleolus	binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)	21		all_hematologic(16;0.0149)|Ovarian(249;0.021)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|Breast(31;0.231)				CCTCCACTGCTTTGGCTTGTT	0.502000														99			4		0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57957254	57957254	+	Silent	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr12:57957254C>T	uc001sor.1	+	1	370	c.162C>T	c.(160-162)ccC>ccT	p.P54P	KIF5A_uc010srr.1_Intron	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	Homo sapiens kinesin family member 5A (KIF5A), mRNA.	54	Kinesin-motor.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						GTGTATTCCCCCCAAACACGA	0.413000														216			5		0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139189307	139189307	+	Silent	SNP	G	A	A	rs146390261		TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr5:139189307G>A	uc003leu.1	+	1	487	c.282G>A	c.(280-282)gcG>gcA	p.A94A		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	Homo sapiens pleckstrin and Sec7 domain containing 2 (PSD2), mRNA.	94					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGATTCAGCGGAGTCCAGGC	0.617000														154			4		0	0	1	0	0
ZFP106	64397	broad.mit.edu	37	15	42734362	42734362	+	Silent	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr15:42734362T>C	uc001zpw.3	-	6	3930	c.3603A>G	c.(3601-3603)caA>caG	p.Q1201Q	ZFP106_uc001zpu.3_Silent_p.Q386Q|ZFP106_uc001zpv.3_Silent_p.Q386Q|ZFP106_uc001zpx.3_Silent_p.Q429Q	NM_022473	NP_071918	Q9H2Y7	ZF106_HUMAN	Homo sapiens zinc finger protein 106 homolog (mouse) (ZFP106), mRNA.	1201						nucleolus	zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	61		all_cancers(109;1.63e-12)|all_epithelial(112;3.97e-11)|Lung NSC(122;2.04e-07)|all_lung(180;8.31e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.6e-07)		ACATGGGCTCTTGTTTAATCT	0.478000														135			4		0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11096982	11096982	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr19:11096982A>G	uc010dxp.3	+	4	833	c.473A>G	c.(472-474)gAc>gGc	p.D158G	SMARCA4_uc010dxo.3_Missense_Mutation_p.D158G|SMARCA4_uc002mqf.4_Missense_Mutation_p.D158G|SMARCA4_uc002mqg.1_Missense_Mutation_p.D158G|SMARCA4_uc010dxq.3_Missense_Mutation_p.D158G|SMARCA4_uc010dxr.3_Missense_Mutation_p.D158G|SMARCA4_uc002mqj.4_Missense_Mutation_p.D158G|SMARCA4_uc010dxs.3_Missense_Mutation_p.D158G|SMARCA4_uc002mqe.2_Missense_Mutation_p.D158G	NM_001128844	NP_003063	P51532	SMCA4_HUMAN	Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), transcript variant 2, mRNA.	158	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of S phase of mitotic cell cycle|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex|WINAC complex|nBAF complex|npBAF complex|nuclear chromatin	ATP binding|DNA binding|DNA-dependent ATPase activity|androgen receptor binding|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GATGGTGCTGACCCCCAGGCC	0.642000			"""F, N, Mis"""		NSCLC									42			5		0	0	1	0	0
MED8	112950	broad.mit.edu	37	1	43850194	43850194	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr1:43850194A>G	uc001cje.1	-	7	881	c.833T>C	c.(832-834)aTc>aCc	p.I278T		NM_052877	NP_443109	Q96G25	MED8_HUMAN	Homo sapiens mediator complex subunit 8 (MED8), transcript variant 3, mRNA.	0					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				endometrium(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	9	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCTTAGAGGGATAGCCAGAAT	0.517000														90			5		0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	21049160	21049160	+	Nonsense_Mutation	SNP	C	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr16:21049160C>A	uc010vbe.2	-	33	4873	c.4873G>T	c.(4873-4875)Gaa>Taa	p.E1625*		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	Homo sapiens dynein, axonemal, heavy chain 3 (DNAH3), mRNA.	1625					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGGACACTTTCATTCTCCTCT	0.507000														88			54		2.22609e-26	2.46805e-26	1	1	0
CCDC59	29080	broad.mit.edu	37	12	82747061	82747061	+	Nonsense_Mutation	SNP	C	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr12:82747061C>A	uc001szp.4	-	3	639	c.595G>T	c.(595-597)Gaa>Taa	p.E199*	CCDC59_uc021rbm.1_Non-coding_Transcript	NM_014167	NP_054886	Q9P031	TAP26_HUMAN	Homo sapiens coiled-coil domain containing 59 (CCDC59), transcript variant 1, mRNA.	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)	5						CTTTGGGCTTCTTCTCTCTCC	0.328000														226			14		7.93312e-07	8.25692e-07	1	1	0
PREX2	80243	broad.mit.edu	37	8	68939495	68939495	+	Silent	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr8:68939495T>C	uc003xxv.1	+	4	507	c.480T>C	c.(478-480)gtT>gtC	p.V160V	PREX2_uc003xxu.1_Silent_p.V160V|PREX2_uc011lez.1_Silent_p.V95V	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	Homo sapiens phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 (PREX2), transcript variant 1, mRNA.	160	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity|protein binding			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						ACACAGATGTTCCCTTGGAAG	0.358000														191			4		0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62462902	62462902	+	Missense_Mutation	SNP	G	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr14:62462902G>T	uc001xfu.1	+	0	362	c.165G>T	c.(163-165)caG>caT	p.Q55H	SYT16_uc010tsd.1_Missense_Mutation_p.Q55H	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	Homo sapiens synaptotagmin XVI (SYT16), mRNA.	55										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		AACTAGATCAGGACTTAGATA	0.388000														160			12		1.08611e-07	1.15399e-07	1	1	0
TNRC6B	23112	broad.mit.edu	37	22	40552184	40552184	+	Silent	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr22:40552184A>G	uc003aym.3	+	3	413	c.111A>G	c.(109-111)aaA>aaG	p.K37K		NM_001024843	NP_001020014	Q9UPQ9	TNR6B_HUMAN	Homo sapiens trinucleotide repeat containing 6B (TNRC6B), transcript variant 3, mRNA.	0					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	RNA binding|nucleotide binding			breast(1)	1						AAGAAAGCAAACAGTGAGTCA	0.448000														85			4		0	0	1	0	0
FLJ43860	389690	broad.mit.edu	37	8	142500306	142500306	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr8:142500306A>C	uc003ywi.2	-	4	689	c.608T>G	c.(607-609)gTg>gGg	p.V203G	FLJ43860_uc011ljs.1_Non-coding_Transcript|FLJ43860_uc010meu.1_Non-coding_Transcript	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	Homo sapiens FLJ43860 protein (FLJ43860), mRNA.	203							binding					all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CTGCGCCACCACCCGCCACGA	0.662000														24			5		0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41003434	41003434	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr19:41003434A>G	uc002ony.3	+	6	793	c.707A>G	c.(706-708)aAt>aGt	p.N236S	SPTBN4_uc002onx.3_Missense_Mutation_p.N236S|SPTBN4_uc002onz.3_Missense_Mutation_p.N236S	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	Homo sapiens spectrin, beta, non-erythrocytic 4 (SPTBN4), transcript variant sigma1, mRNA.	236	Actin-binding.|CH 2.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	PML body|cytosol|nuclear matrix|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton	p.S235S(1)		breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACCAAGTCCAATGCCAACTAC	0.662000														59			10		0	0	1	0	0
ZNF155	7711	broad.mit.edu	37	19	44500350	44500350	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr19:44500350C>T	uc010xwt.1	+	5	558	c.374C>T	c.(373-375)tCt>tTt	p.S125F	ZNF155_uc002oxy.1_Missense_Mutation_p.S114F|ZNF155_uc002oxz.1_Missense_Mutation_p.S114F	NM_198089	NP_932355	Q12901	ZN155_HUMAN	Homo sapiens zinc finger protein 155 (ZNF155), transcript variant 2, mRNA.	114						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				TTAACCAGGTCTCAGGACTCT	0.448000														117			12		0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171073025	171073025	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr1:171073025T>C	uc001ghi.3	+	2	343	c.232T>C	c.(232-234)Ttc>Ctc	p.F78L	FMO3_uc001ghh.3_Missense_Mutation_p.F78L|FMO3_uc010pmb.2_Missense_Mutation_p.F58L|FMO3_uc010pmc.2_Intron|MIR1295A_uc021pes.1_5'Flank	NM_001002294	NP_008825	P31513	FMO3_HUMAN	Homo sapiens flavin containing monooxygenase 3 (FMO3), transcript variant 2, mRNA.	78					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TCCCGATGACTTCCCCAACTT	0.418000														91			4		0	0	1	0	0
PNRC1	10957	broad.mit.edu	37	6	89793802	89793802	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr6:89793802A>G	uc003pmv.3	+	1	1056	c.871A>G	c.(871-873)Agt>Ggt	p.S291G	PNRC1_uc021zcp.1_Missense_Mutation_p.S212G|PNRC1_uc003pmx.3_Missense_Mutation_p.S106G	NM_006813	NP_006804	Q12796	PNRC1_HUMAN	Homo sapiens proline-rich nuclear receptor coactivator 1 (PNRC1), mRNA.	291					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		ACCTTCTCCTAGTGTTCTTCC	0.413000										Multiple Myeloma(7;0.094)				24			60		0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195509957	195509957	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr3:195509957A>G	uc021xjp.1	-	1	8650	c.8494T>C	c.(8494-8496)Tct>Cct	p.S2832P	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	575					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACAGGAAGAGAGGTGGCATGA	0.592000														12			4		0	0	1	0	0
LAIR1	3903	broad.mit.edu	37	19	54875936	54875936	+	Splice_Site	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr19:54875936C>T	uc002qfk.1	-	2	345	c.35_splice	c.e2-1	p.V12_splice	LAIR1_uc002qfl.1_Splice_Site_p.V12_splice|LAIR1_uc002qfm.1_Splice_Site_p.V12_splice|LAIR1_uc002qfn.1_Splice_Site_p.V12_splice|LAIR1_uc010yex.2_Splice_Site_p.V6_splice|LAIR1_uc002qfo.3_Intron	NM_002287	NP_002278	Q6GTX8	LAIR1_HUMAN	Homo sapiens leukocyte-associated immunoglobulin-like receptor 1 (LAIR1), transcript variant a, mRNA.	12						integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(9)|ovary(4)|prostate(1)|stomach(3)	26	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0573)		CCAGGCAGAGCACTGGAAGAG	0.612000														66			19		0	0	1	0	0
GFM1	85476	broad.mit.edu	37	3	158363431	158363431	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr3:158363431C>T	uc003fce.3	+	1	202	c.95C>T	c.(94-96)gCc>gTc	p.A32V	GFM1_uc003fcd.3_Missense_Mutation_p.A32V|GFM1_uc003fcg.3_5'Flank	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	Homo sapiens G elongation factor, mitochondrial 1 (GFM1), nuclear gene encoding mitochondrial protein, mRNA.	32					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|urinary_tract(2)	22			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			AATTGGAAGGCCTGCCGATGG	0.373000														77			8		0	0	1	0	0
OSBPL3	26031	broad.mit.edu	37	7	24931999	24931999	+	Silent	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr7:24931999T>C	uc003sxf.3	-	1	498	c.93A>G	c.(91-93)cgA>cgG	p.R31R	OSBPL3_uc003sxd.3_Non-coding_Transcript|OSBPL3_uc003sxe.3_Non-coding_Transcript|OSBPL3_uc003sxg.3_Silent_p.R31R|OSBPL3_uc003sxh.3_Silent_p.R31R|OSBPL3_uc003sxi.3_Silent_p.R31R	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	Homo sapiens oxysterol binding protein-like 3 (OSBPL3), transcript variant 1, mRNA.	31					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						ACTTTACCTGTCGACTTCCTT	0.408000														96			5		0	0	1	0	0
SLC35D1	23169	broad.mit.edu	37	1	67486077	67486077	+	Missense_Mutation	SNP	G	A	A	rs143745141		TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr1:67486077G>A	uc001ddk.2	-	9	1235	c.851C>T	c.(850-852)aCa>aTa	p.T284I	SLC35D1_uc010oph.2_Missense_Mutation_p.T205I	NM_015139	NP_055954	Q9NTN3	S35D1_HUMAN	Homo sapiens solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (SLC35D1), mRNA.	284					UDP-glucuronate biosynthetic process|chondroitin sulfate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-N-acetylgalactosamine transmembrane transporter activity|UDP-glucuronic acid transmembrane transporter activity	p.L283V(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(4)	10					Lorazepam(DB00186)	TATTGTAGTTGTAAGAGCAGA	0.333000														13			50		0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109696984	109696984	+	Missense_Mutation	SNP	G	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chrX:109696984G>T	uc004eor.2	+	2	3385	c.3139G>T	c.(3139-3141)Gcc>Tcc	p.A1047S	RGAG1_uc011msr.1_Missense_Mutation_p.A1047S	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	Homo sapiens retrotransposon gag domain containing 1 (RGAG1), mRNA.	1047										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						ACTACCAAGAGCCACAGCCTC	0.547000														12			35		8.01111e-26	8.69291e-26	1	1	0
ANK2	287	broad.mit.edu	37	4	114278579	114278579	+	Silent	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr4:114278579T>C	uc003ibe.4	+	37	8905	c.8805T>C	c.(8803-8805)tcT>tcC	p.S2935S	ANK2_uc003ibd.4_Intron|ANK2_uc003ibf.4_Intron|ANK2_uc011cgc.2_Intron|ANK2_uc003ibg.4_Intron|ANK2_uc003ibh.4_Intron|ANK2_uc011cgb.1_Silent_p.S2950S	NM_001148	NP_001139	Q01484	ANK2_HUMAN	Homo sapiens ankyrin 2, neuronal (ANK2), transcript variant 1, mRNA.	2902					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTTCCCAATCTTTTTTCTCTA	0.398000														196			5		0	0	1	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117784539	117784539	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr11:117784539C>G	uc001prs.2	-	4	908	c.762G>C	c.(760-762)tgG>tgC	p.W254C	TMPRSS13_uc009yzr.2_Missense_Mutation_p.W219C|TMPRSS13_uc021qrc.1_Missense_Mutation_p.W254C|TMPRSS13_uc001prt.1_5'UTR|TMPRSS13_uc001pru.2_Missense_Mutation_p.W254C	NM_001077263	NP_001070731	Q9BYE2	TMPSD_HUMAN	Homo sapiens transmembrane protease, serine 13 (TMPRSS13), transcript variant 1, mRNA.	249	SRCR.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		AGGAGTCATTCCAGTTGCTGC	0.537000														59			3		0	0	1	0	0
LOC440563	440563	broad.mit.edu	37	1	13183837	13183837	+	Silent	SNP	G	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr1:13183837G>A	uc010obg.2	-	1	279	c.36C>T	c.(34-36)caC>caT	p.H12H		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	Homo sapiens heterogeneous nuclear ribonucleoprotein C-like (LOC440563), mRNA.	12						ribonucleoprotein complex	nucleic acid binding|nucleotide binding										AGTTCACGGAGTGAGGATCCA	0.463000														127			4		0	0	1	0	0
POLDIP2	26073	broad.mit.edu	37	17	26677558	26677558	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr17:26677558T>C	uc002haz.3	-	9	942	c.812A>G	c.(811-813)gAc>gGc	p.D271G	POLDIP2_uc010wag.2_Non-coding_Transcript	NM_015584	NP_056399	Q9Y2S7	PDIP2_HUMAN	Homo sapiens polymerase (DNA-directed), delta interacting protein 2 (POLDIP2), mRNA.	273	ApaG.					mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CACATCACTGTCAAGGTTCTC	0.532000														22			4		0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471894	92471894	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr14:92471894A>C	uc001xzy.3	-	10	2800	c.2426T>G	c.(2425-2427)cTt>cGt	p.L809R	TRIP11_uc010auf.2_Missense_Mutation_p.L545R	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	809					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CTTGTTTATAAGTTGTGTCAA	0.318000			T	PDGFRB	AML									112			60		0	0	1	0	0
TCOF1	6949	broad.mit.edu	37	5	149773014	149773014	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr5:149773014C>G	uc003lry.3	+	22	3788	c.3680C>G	c.(3679-3681)tCc>tGc	p.S1227C	TCOF1_uc003lrz.3_Missense_Mutation_p.S1189C|TCOF1_uc011dch.2_Missense_Mutation_p.S1190C|TCOF1_uc003lrx.3_Missense_Mutation_p.S1151C|TCOF1_uc003lsa.3_Missense_Mutation_p.S1150C	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Homo sapiens Treacher Collins-Franceschetti syndrome 1 (TCOF1), transcript variant 4, mRNA.	1227					skeletal system development	nucleolus	protein binding|transporter activity			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	35		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCTAGACTCCAGCCCCTCA	0.542000														48			32		0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24226120	24226120	+	Silent	SNP	G	A	A			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr22:24226120G>A	uc011ajc.1	+	8	1555	c.1065G>A	c.(1063-1065)ccG>ccA	p.P355P	SLC2A11_uc002zyl.1_3'UTR|SLC2A11_uc002zym.4_Intron|SLC2A11_uc002zyn.4_Intron|SLC2A11_uc002zyo.4_Intron|SLC2A11_uc002zyp.4_Intron			Q9BYW1	GTR11_HUMAN	Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 11 (SLC2A11), transcript variant 1, mRNA.	357						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						CCTCACCCCCGCCCCGTCCAC	0.657000														69			40		0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42225041	42225041	+	Silent	SNP	C	G	G	rs149056934		TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr19:42225041C>G	uc002orl.3	+	7	2092	c.1971C>G	c.(1969-1971)gtC>gtG	p.V657V	CEACAM5_uc002orj.1_Silent_p.V656V	NM_004363	NP_004354	P06731	CEAM5_HUMAN	Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), mRNA.	657	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCTGTTTTGTCTCTAACTTGG	0.463000														141			48		0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42355997	42355997	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr14:42355997C>T	uc001wvm.3	+	2	1367	c.169C>T	c.(169-171)Cgg>Tgg	p.R57W	LRFN5_uc010ana.3_Missense_Mutation_p.R57W	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	Homo sapiens leucine rich repeat and fibronectin type III domain containing 5 (LRFN5), mRNA.	57						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGTGGAACTGCGGTTGGCAGA	0.383000										HNSCC(30;0.082)				234			4		0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65194463	65194464	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr14:65194463_65194464insC	uc001xhp.2	+	0	153_154	c.114_115insC	c.(112-117)gagcccfs	p.E38fs	PLEKHG3_uc001xhn.1_Frame_Shift_Ins_p.E38fs|PLEKHG3_uc001xho.1_Frame_Shift_Ins_p.E38fs|PLEKHG3_uc010aqh.1_5'Flank	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 3 (PLEKHG3), mRNA.	38	Ser-rich.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CCATGGAGGAGCCCAGCAGCTC	0.644													---	130	---	---	10	---					
FMN1	342184	broad.mit.edu	37	15	33261112	33261113	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KN-8426-01A-11D-2310-10	TCGA-KN-8426-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a3deafcb-b54f-4b7e-89ac-c92c16fb919f	fb5c34ce-5b82-4bd7-a195-5f0c2dab07d4	g.chr15:33261112_33261113insG	uc001zhf.4	-	3	2120_2121	c.2120_2121insC	c.(2119-2121)cttfs	p.L707fs	SNORD77_uc021sip.1_5'Flank	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	Homo sapiens formin 1 (FMN1), mRNA.	930	Mediates interaction with alpha-catenin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GGGAGTTAGGAAgtgggggtgg	0.668													---	30	---	---	7	---					
