Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCAP	22937	broad.mit.edu	37	3	47462126	47462126	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr3:47462126G>A	uc003crh.1	-	11	1736	c.1481C>T	c.(1480-1482)tCc>tTc	p.S494F	SCAP_uc011baz.1_Missense_Mutation_p.S239F|SCAP_uc003crg.2_Missense_Mutation_p.S102F	NM_012235	NP_036367	Q12770	SCAP_HUMAN	Homo sapiens SREBF chaperone (SCAP), mRNA.	494					cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	ER to Golgi transport vesicle membrane|Golgi membrane|endoplasmic reticulum membrane|integral to membrane	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	26				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		GTTTCGGAAGGAAGACGGCTG	0.662000											OREG0015548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		41			3		0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171072967	171072967	+	Silent	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:171072967C>T	uc001ghi.3	+	2	285	c.174C>T	c.(172-174)gtC>gtT	p.V58V	FMO3_uc001ghh.3_Silent_p.V58V|FMO3_uc010pmb.2_Silent_p.V38V|FMO3_uc010pmc.2_Intron|MIR1295A_uc021pes.1_5'Flank	NM_001002294	NP_008825	P31513	FMO3_HUMAN	Homo sapiens flavin containing monooxygenase 3 (FMO3), transcript variant 2, mRNA.	58					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ACAAATCAGTCTTTTCCAACT	0.423000														120			35		0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100515270	100515270	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr3:100515270A>G	uc003dun.3	-	20	1875	c.1790T>C	c.(1789-1791)gTc>gCc	p.V597A	ABI3BP_uc003duj.3_Missense_Mutation_p.V152A|ABI3BP_uc003duk.3_Missense_Mutation_p.V281A|ABI3BP_uc003dul.3_Missense_Mutation_p.V402A|ABI3BP_uc011bhd.2_Missense_Mutation_p.V551A|ABI3BP_uc003dum.3_Intron	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	Homo sapiens ABI family, member 3 (NESH) binding protein (ABI3BP), mRNA.	597	Pro-rich.					extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GCTCTGAGAGACCTCAGGGTA	0.328000														143			5		0	0	1	0	0
GPR87	53836	broad.mit.edu	37	3	151012813	151012813	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr3:151012813G>A	uc003eyt.2	-	2	582	c.221C>T	c.(220-222)aCc>aTc	p.T74I	MED12L_uc003eyp.3_Intron|MED12L_uc011bnz.2_Intron	NM_023915	NP_076404	Q9BY21	GPR87_HUMAN	Homo sapiens G protein-coupled receptor 87 (GPR87), mRNA.	74						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(6)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	19			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TATGAAGCTGGTTTTATTCCT	0.403000														122			8		0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65811124	65811124	+	Missense_Mutation	SNP	G	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr11:65811124G>T	uc001ogv.3	-	1	310	c.150C>A	c.(148-150)agC>agA	p.S50R	GAL3ST3_uc001ogw.3_Missense_Mutation_p.S50R	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	Homo sapiens galactose-3-O-sulfotransferase 3 (GAL3ST3), mRNA.	50					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity	p.L49F(1)		kidney(1)|lung(9)|ovary(2)|skin(2)	14						GAGGAGGGCAGCTCAAGGGGA	0.647000														62			7		0.00448238	0.00448238	1	1	0
COPA	1314	broad.mit.edu	37	1	160275563	160275563	+	Splice_Site	SNP	C	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:160275563C>G	uc001fvv.4	-	16	1837	c.1443_splice	c.e16-1	p.R481_splice	COPA_uc009wti.3_Splice_Site_p.R481_splice|COPA_uc009wtj.1_Splice_Site_p.R427_splice	NM_001098398	NP_001091868	P53621	COPA_HUMAN	Homo sapiens coatomer protein complex, subunit alpha (COPA), transcript variant 1, mRNA.	481					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGCCAGAGTCCTGAGATAGA	0.398000														92			13		0	0	1	0	0
C9orf72	203228	broad.mit.edu	37	9	27556771	27556771	+	Silent	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr9:27556771C>T	uc003zqq.2	-	7	976	c.879G>A	c.(877-879)ctG>ctA	p.L293L	C9orf72_uc022bfa.1_Silent_p.L293L	NM_018325	NP_060795	Q96LT7	CI072_HUMAN	Homo sapiens chromosome 9 open reading frame 72 (C9orf72), transcript variant 2, mRNA.	293										breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|pancreas(1)	23		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		GCCGGAAAGGCAGCACAAAGC	0.363000														54			20		0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680520	114680520	+	Missense_Mutation	SNP	T	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:114680520T>G	uc021osa.1	-	2	746	c.668A>C	c.(667-669)aAg>aCg	p.K223T	SYT6_uc021orz.1_Missense_Mutation_p.K138T|SYT6_uc001eev.3_Missense_Mutation_p.K138T	NM_001253772	NP_001240701	Q5T7P8	SYT6_HUMAN	Homo sapiens synaptotagmin VI (SYT6), transcript variant 1, mRNA.	223					acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCCTCAGACTTGGCATCCTC	0.557000														138			18		0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132081945	132081945	+	Missense_Mutation	SNP	G	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr11:132081945G>T	uc010sci.2	+	3	761	c.430G>T	c.(430-432)Gat>Tat	p.D144Y	NTM_uc001qgm.3_Missense_Mutation_p.D144Y|NTM_uc010sch.2_Missense_Mutation_p.D135Y|NTM_uc010scj.2_Missense_Mutation_p.D103Y|NTM_uc001qgo.3_Missense_Mutation_p.D144Y|NTM_uc001qgq.3_Missense_Mutation_p.D144Y|NTM_uc001qgp.3_Missense_Mutation_p.D144Y	NM_001144058	NP_001137530	Q9P121	NTRI_HUMAN	Homo sapiens neurotrimin (NTM), transcript variant 3, mRNA.	144	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						GATTTCTTCAGATATCTCCAT	0.383000														63			11		5.50884e-06	5.59359e-06	1	1	0
SRCRB4D	136853	broad.mit.edu	37	7	76021323	76021323	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr7:76021323C>G	uc003ufb.3	-	9	1717	c.1369G>C	c.(1369-1371)Ggt>Cgt	p.G457R	SRCRB4D_uc003ufa.3_5'UTR	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	Homo sapiens scavenger receptor cysteine rich domain containing, group B (4 domains) (SRCRB4D), mRNA.	457						extracellular region|membrane	scavenger receptor activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						GTCTCAGAACCATCCTGCTGG	0.592000														17			7		0	0	1	0	0
MARCH1	55016	broad.mit.edu	37	4	164466780	164466780	+	Missense_Mutation	SNP	G	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr4:164466780G>C	uc003iqs.2	-	6	721	c.539C>G	c.(538-540)aCa>aGa	p.T180R	MARCH1_uc003iqr.2_Missense_Mutation_p.T163R	NM_001166373	NP_001159845	Q8TCQ1	MARH1_HUMAN	Homo sapiens membrane-associated ring finger (C3HC4) 1 (MARCH1), transcript variant 1, mRNA.	180					antigen processing and presentation of peptide antigen via MHC class II|immune response	Golgi apparatus|cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TTCCTCCGCTGTCCGGTCTAT	0.438000														46			58		0	0	1	0	0
EPT1	85465	broad.mit.edu	37	2	26596325	26596325	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:26596325T>C	uc021veu.1	+	4	548	c.401T>C	c.(400-402)gTt>gCt	p.V134A	EPT1_uc010eyl.1_Non-coding_Transcript	NM_033505		Q9C0D9	EPT1_HUMAN	Homo sapiens ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific) (EPT1), mRNA.	134					phospholipid biosynthetic process	integral to membrane	ethanolaminephosphotransferase activity|metal ion binding										TGGTCATGTGTTTACTTTGTT	0.423000														384			6		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118114	118114	+	RNA	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chrGL000205.1:118114C>T	uc002kgk.4	+	0		c.1492C>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		CTCTCACTGCCTGCTACAGCC	0.552000														43			10		0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197026583	197026583	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:197026583C>T	uc001gtt.1	-	5	862	c.818G>A	c.(817-819)aGa>aAa	p.R273K		NM_001994	NP_001985	P05160	F13B_HUMAN	Homo sapiens coagulation factor XIII, B polypeptide (F13B), mRNA.	273	Sushi 5.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						AGGAGGACATCTGTTTCTTCT	0.294000														82			66		0	0	1	0	0
DDX50	79009	broad.mit.edu	37	10	70702984	70702984	+	Missense_Mutation	SNP	G	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr10:70702984G>C	uc001jou.3	+	13	2013	c.1906G>C	c.(1906-1908)Gtt>Ctt	p.V636L		NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 (DDX50), mRNA.	636						nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	29						TTGCTTTGATGTTCCTACAAC	0.289000														46			25		0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48267232	48267232	+	Missense_Mutation	SNP	G	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr17:48267232G>C	uc002iqm.3	-	36	2727	c.2601C>G	c.(2599-2601)agC>agG	p.S867R		NM_000088	NP_000079	P02452	CO1A1_HUMAN	Homo sapiens collagen, type I, alpha 1 (COL1A1), mRNA.	867	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GGGGACCAGCGCTGCCGCGAG	0.652000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta							29			24		0	0	1	0	0
MORN5	254956	broad.mit.edu	37	9	124936966	124936966	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr9:124936966C>A	uc011lyn.2	+	3	561	c.499C>A	c.(499-501)Ctg>Atg	p.L167M	MORN5_uc011lyo.1_Intron|MORN5_uc004blw.2_Intron	NM_198469	NP_940871	Q5VZ52	MORN5_HUMAN	Homo sapiens MORN repeat containing 5 (MORN5), mRNA.	0										endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	9						GTATGTGCATCTGTATGTACA	0.403000														24			19		3.99206e-14	4.46569e-14	1	1	0
AGBL1	123624	broad.mit.edu	37	15	86808034	86808034	+	Silent	SNP	C	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr15:86808034C>A	uc002blz.1	+	9	1574	c.1494C>A	c.(1492-1494)acC>acA	p.T498T	AGBL1_uc002bma.1_Silent_p.T229T|AGBL1_uc002bmb.1_Silent_p.T192T	NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	Homo sapiens ATP/GTP binding protein-like 1 (AGBL1), mRNA.	498					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding	p.T498I(1)		NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						CTCCCACCACCCAGCCTATGT	0.458000														33			37		7.63091e-17	8.68345e-17	1	1	0
KYNU	8942	broad.mit.edu	37	2	143713785	143713785	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:143713785A>G	uc010fnm.3	+	6	665	c.449A>G	c.(448-450)aAg>aGg	p.K150R	KYNU_uc002tvk.3_Missense_Mutation_p.K150R|KYNU_uc002tvl.3_Missense_Mutation_p.K150R	NM_001199241	NP_001186170	Q16719	KYNU_HUMAN	Homo sapiens kynureninase (KYNU), transcript variant 3, mRNA.	150					NAD biosynthetic process|anthranilate metabolic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TCATTTTTTAAGCCTACGCCA	0.289000														69			16		0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382811	152382811	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:152382811C>A	uc001ezx.2	-	2	821	c.747G>T	c.(745-747)caG>caT	p.Q249H		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	Homo sapiens cornulin (CRNN), mRNA.	249	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCTTCCTGTCTGGTGGCTGC	0.597000														256			28		1.17739e-12	1.2739e-12	1	1	0
MMP12	4321	broad.mit.edu	37	11	102737125	102737125	+	Silent	SNP	A	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr11:102737125A>C	uc001phk.3	-	7	1060	c.963T>G	c.(961-963)tcT>tcG	p.S321S		NM_002426	NP_002417	P39900	MMP12_HUMAN	Homo sapiens matrix metallopeptidase 12 (macrophage elastase) (MMP12), mRNA.	322	Hemopexin-like 1.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	GCCATAAGGAAGAAATTAAAT	0.353000														83			28		0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72348987	72348987	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr17:72348987G>A	uc002jkm.4	+	14	2146	c.2008G>A	c.(2008-2010)Gca>Aca	p.A670T		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	Homo sapiens kinesin family member 19 (KIF19), mRNA.	670					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.A670A(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						AATTACCCCAGCAGGAACCTC	0.567000														39			17		0	0	1	0	0
GARNL3	84253	broad.mit.edu	37	9	130075815	130075815	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr9:130075815C>T	uc011mae.2	+	3	816	c.415C>T	c.(415-417)Cgt>Tgt	p.R139C	GARNL3_uc011mad.2_Missense_Mutation_p.R117C	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	Homo sapiens GTPase activating Rap/RanGAP domain-like 3 (GARNL3), mRNA.	139					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						CCCTCAATACCGTGCAATTCT	0.438000														73			3		0	0	1	0	0
MS4A5	64232	broad.mit.edu	37	11	60198312	60198312	+	Missense_Mutation	SNP	T	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr11:60198312T>G	uc001npo.3	+	1	283	c.197T>G	c.(196-198)gTt>gGt	p.V66G		NM_023945	NP_076434	Q9H3V2	MS4A5_HUMAN	Homo sapiens membrane-spanning 4-domains, subfamily A, member 5 (MS4A5), mRNA.	66						integral to membrane	receptor activity	p.G65*(1)		large_intestine(7)|lung(7)|ovary(1)|skin(1)	16						TCTTTTGGAGTTATCTTCCTT	0.373000														89			28		0	0	1	0	0
MBD5	55777	broad.mit.edu	37	2	149247532	149247532	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:149247532A>C	uc002twm.4	+	11	4629	c.3632A>C	c.(3631-3633)aAg>aCg	p.K1211T	MBD5_uc010zbs.2_Intron|MBD5_uc002two.3_Missense_Mutation_p.K469T|MBD5_uc002twp.3_Missense_Mutation_p.K261T	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	Homo sapiens methyl-CpG binding domain protein 5 (MBD5), mRNA.	1211						chromosome|nucleus	DNA binding|chromatin binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		AACAGGTGGAAGTACGAGGAA	0.488000														84			16		0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61525220	61525220	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr20:61525220C>A	uc002ydr.2	-	11	3211	c.2899G>T	c.(2899-2901)Gac>Tac	p.D967Y	DIDO1_uc002yds.2_Missense_Mutation_p.D967Y|DIDO1_uc002ydt.2_Missense_Mutation_p.D967Y|DIDO1_uc002ydu.2_Missense_Mutation_p.D967Y	NM_001193369	NP_149072	Q9BTC0	DIDO1_HUMAN	Homo sapiens death inducer-obliterator 1 (DIDO1), transcript variant 5, mRNA.	967					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GTCCTGGGGTCCCGGCCGGAC	0.677000														77			7		3.09899e-07	3.19583e-07	1	1	0
ZNF445	353274	broad.mit.edu	37	3	44489837	44489837	+	Silent	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr3:44489837C>T	uc003cnf.2	-	7	1674	c.1326G>A	c.(1324-1326)ggG>ggA	p.G442G	ZNF445_uc011azv.1_Silent_p.G430G|ZNF445_uc011azw.1_Silent_p.G442G	NM_181489	NP_852466	P59923	ZN445_HUMAN	Homo sapiens zinc finger protein 445 (ZNF445), mRNA.	442					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GGCTGAAGCCCCCAATCATGT	0.463000														132			4		0	0	1	0	0
CYP11B1	1584	broad.mit.edu	37	8	143958438	143958438	+	Splice_Site	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr8:143958438C>T	uc010mey.3	-	5	815	c.808_splice	c.e5+1	p.A270_splice	CYP11B1_uc010mex.3_5'Flank|CYP11B1_uc003yxh.3_5'Flank|CYP11B1_uc003yxi.3_Splice_Site_p.A199_splice|CYP11B1_uc003yxj.3_Splice_Site_p.A199_splice	NM_000497	NP_000488	P15538	C11B1_HUMAN	Homo sapiens cytochrome P450, family 11, subfamily B, polypeptide 1 (CYP11B1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	199					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GTGGCCCACACCTTCTATGGT	0.652000									Familial Hyperaldosteronism type I					79			33		0	0	1	0	0
PROM2	150696	broad.mit.edu	37	2	95944771	95944771	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:95944771A>G	uc002suk.3	+	9	1286	c.1153A>G	c.(1153-1155)Agg>Ggg	p.R385G	PROM2_uc002suh.2_Missense_Mutation_p.R385G|PROM2_uc002sui.3_Missense_Mutation_p.R385G|PROM2_uc002suj.3_Missense_Mutation_p.R39G|PROM2_uc002sul.3_5'UTR|PROM2_uc002sum.3_5'Flank	NM_001165977	NP_653308	Q8N271	PROM2_HUMAN	Homo sapiens prominin 2 (PROM2), transcript variant 2, mRNA.	385						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						GGAAGGGGTGAGGACACTGGC	0.657000														170			5		0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94487339	94487339	+	Silent	SNP	C	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr9:94487339C>G	uc004arj.2	-	8	1636	c.1437G>C	c.(1435-1437)ctG>ctC	p.L479L	ROR2_uc004ari.1_Silent_p.L339L	NM_004560	NP_004551	Q01974	ROR2_HUMAN	Homo sapiens receptor tyrosine kinase-like orphan receptor 2 (ROR2), mRNA.	479	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|Wnt-protein binding|transmembrane receptor protein tyrosine kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGTCCTCTCCCAGCTCCTCCA	0.572000														37			7		0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110530424	110530424	+	Silent	SNP	T	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr8:110530424T>C	uc003yne.3	+	72	11822	c.11718T>C	c.(11716-11718)acT>acC	p.T3906T		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 (PKHD1L1), mRNA.	3906					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGGATTCCACTGTCCTTGGTG	0.363000										HNSCC(38;0.096)				108			20		0	0	1	0	0
ARL4C	10123	broad.mit.edu	37	2	235404686	235404686	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:235404686C>T	uc002vvm.4	-	0	548	c.545G>A	c.(544-546)cGc>cAc	p.R182H	ARL4C_uc002vvn.3_Missense_Mutation_p.R182H	NM_005737	NP_005728	P56559	ARL4C_HUMAN	Homo sapiens ADP-ribosylation factor-like 4C (ARL4C), mRNA.	182					endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	GTP binding|GTPase activity|alpha-tubulin binding	p.R182H(2)		endometrium(1)|ovary(1)|skin(1)|urinary_tract(1)	4		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		GGACTTCCTGCGTTTCAGGAT	0.587000														72			18		0	0	1	0	0
CPLX2	10814	broad.mit.edu	37	5	175306003	175306003	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr5:175306003C>T	uc003mde.1	+	3	470	c.124C>T	c.(124-126)Cgg>Tgg	p.R42W	CPLX2_uc003mdf.1_Missense_Mutation_p.R42W	NM_006650	NP_006641	Q6PUV4	CPLX2_HUMAN	Homo sapiens complexin 2 (CPLX2), transcript variant 1, mRNA.	42	Interaction with the SNARE complex (By similarity).				mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				endometrium(3)|kidney(2)|lung(3)|ovary(2)	10	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ggaggcgctgcggcagcagga	0.672000														88			16		0	0	1	0	0
DDRGK1	65992	broad.mit.edu	37	20	3172425	3172425	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr20:3172425C>A	uc002wic.3	-	6	737	c.715G>T	c.(715-717)Ggc>Tgc	p.G239C		NM_023935	NP_076424	Q96HY6	DDRGK_HUMAN	Homo sapiens DDRGK domain containing 1 (DDRGK1), mRNA.	239	PCI.					endoplasmic reticulum	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(1)	7						GTGCGTAGGCCCACCTGGGAA	0.547000														41			23		3.08376e-08	3.23061e-08	1	1	0
FGFBP2	83888	broad.mit.edu	37	4	15964500	15964500	+	Missense_Mutation	SNP	C	T	T	rs111244757		TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr4:15964500C>T	uc003gon.3	-	0	360	c.253G>A	c.(253-255)Gct>Act	p.A85T	FGFBP2_uc021xmm.1_Missense_Mutation_p.A85T	NM_031950	NP_114156	Q9BYJ0	FGFP2_HUMAN	Homo sapiens fibroblast growth factor binding protein 2 (FGFBP2), mRNA.	85						extracellular space	growth factor binding			central_nervous_system(1)|lung(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	9						GGGTCAGCAGCGAAAGCCTGG	0.622000														15			9		0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113988244	113988244	+	Silent	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr8:113988244A>G	uc003ynu.3	-	6	1323	c.1164T>C	c.(1162-1164)caT>caC	p.H388H	CSMD3_uc003ynt.3_Silent_p.H348H|CSMD3_uc011lhx.2_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	Homo sapiens CUB and Sushi multiple domains 3 (CSMD3), transcript variant a, mRNA.	388						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CGGAAAGTCTATGGATGGTGA	0.502000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)				240			24		0	0	1	0	0
RPP25L	138716	broad.mit.edu	37	9	34611014	34611014	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr9:34611014C>T	uc022bgh.1	-	0	280	c.280G>A	c.(280-282)Gac>Aac	p.D94N	RPP25L_uc003zuu.3_Missense_Mutation_p.D94N|RPP25L_uc003zuv.3_Missense_Mutation_p.D94N	NM_148179	NP_680545	Q8N5L8	CI023_HUMAN	Homo sapiens chromosome 9 open reading frame 23 (C9orf23), transcript variant 2, mRNA.	94							nucleic acid binding										ACCCAGCTGTCCTCAGTCTGA	0.647000														47			3		0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33113433	33113433	+	Silent	SNP	G	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr19:33113433G>T	uc002ntn.1	-	17	1878	c.1722C>A	c.(1720-1722)cgC>cgA	p.R574R		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	Homo sapiens ankyrin repeat domain 27 (VPS9 domain) (ANKRD27), mRNA.	574					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					GGTAGCCCCAGCGGGCAGCAA	0.532000														114			13		9.05144e-12	9.63541e-12	1	1	0
DCLRE1A	9937	broad.mit.edu	37	10	115609249	115609249	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr10:115609249G>A	uc001law.2	-	1	2533	c.1615C>T	c.(1615-1617)Cct>Tct	p.P539S		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	Homo sapiens DNA cross-link repair 1A (DCLRE1A), mRNA.	539	Nuclear focus formation.				cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		AGACCAGAAGGCAATATTTTC	0.383000								Other identified genes with known or suspected DNA repair function						98			5		0	0	1	0	0
PRDX2	7001	broad.mit.edu	37	19	12911998	12911998	+	Silent	SNP	T	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr19:12911998T>C	uc002mvd.3	-	1	228	c.78A>G	c.(76-78)aaA>aaG	p.K26K	PRDX2_uc002mve.1_Silent_p.K26K	NM_005809	NP_005800	P32119	PRDX2_HUMAN	Homo sapiens peroxiredoxin 2 (PRDX2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	26	Thioredoxin.				anti-apoptosis|cell redox homeostasis|hydrogen peroxide catabolic process|removal of superoxide radicals		thioredoxin peroxidase activity	p.K26I(1)		endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	4						GCTTCACCTCTTTGAAGGCGC	0.637000														80			21		0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117248566	117248566	+	Silent	SNP	G	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr6:117248566G>T	uc003pxm.3	+	16	2325	c.2262G>T	c.(2260-2262)ccG>ccT	p.P754P		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	Homo sapiens regulatory factor X, 6 (RFX6), mRNA.	754					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						CCCGGCCACCGTCTAGCTATG	0.512000														25			33		2.05212e-20	2.41857e-20	1	1	0
HYDIN	54768	broad.mit.edu	37	GL000192.1	311344	311344	+	RNA	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chrGL000192.1:311344C>T	uc010yij.1	-	6		c.1025G>A			HYDIN_uc021vdl.1_Non-coding_Transcript	NM_017558		Q4G0P3	HYDIN_HUMAN	Homo sapiens HYDIN, axonemal central pair apparatus protein (HYDIN), transcript variant 2, mRNA.											breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TACCTTGCTGCAATTAAGAGC	0.577000														25			4		0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620544	7620544	+	Missense_Mutation	SNP	G	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr3:7620544G>C	uc003bqm.2	+	7	2225	c.1951G>C	c.(1951-1953)Gat>Cat	p.D651H	GRM7_uc011ata.1_Non-coding_Transcript|GRM7_uc011atb.1_Non-coding_Transcript|GRM7_uc010hcf.2_Non-coding_Transcript|GRM7_uc011atc.1_Non-coding_Transcript|GRM7_uc010hcg.2_Missense_Mutation_p.D651H|GRM7_uc003bql.2_Missense_Mutation_p.D651H|GRM7_uc003bqn.1_Missense_Mutation_p.D234H|GRM7_uc010hch.1_Missense_Mutation_p.D162H	NM_000844	NP_000835	Q14831	GRM7_HUMAN	Homo sapiens glutamate receptor, metabotropic 7 (GRM7), transcript variant 1, mRNA.	651					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	PDZ domain binding|adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TGCCAAACCAGATGTGGCAGT	0.478000														115			17		0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53670499	53670499	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr12:53670499C>G	uc001sck.2	+	7	1887	c.1796C>G	c.(1795-1797)aCt>aGt	p.T599S	ESPL1_uc001scj.2_Missense_Mutation_p.T274S|ESPL1_uc010soe.1_5'Flank	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	Homo sapiens extra spindle pole bodies homolog 1 (S. cerevisiae) (ESPL1), mRNA.	599					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CGGGCCGACACTGGACAGGAA	0.662000														34			5		0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179644742	179644742	+	Silent	SNP	A	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:179644742A>C	uc021vsy.1	-	21	3939	c.3714T>G	c.(3712-3714)acT>acG	p.T1238T	TTN_uc021vsz.1_Silent_p.T1192T|TTN_uc021vta.1_Silent_p.T1192T|TTN_uc021vtb.1_Silent_p.T1192T|TTN_uc002unb.2_Silent_p.T1238T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	1238							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.T1192T(5)|p.T1238T(4)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTACATAAGTTCTGACCA	0.308000														259			22		0	0	1	0	0
ZNF667	63934	broad.mit.edu	37	19	56952705	56952705	+	Silent	SNP	T	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr19:56952705T>C	uc002qne.3	-	6	2450	c.1659A>G	c.(1657-1659)aaA>aaG	p.K553K	ZNF667_uc010etl.3_Silent_p.K335K|ZNF667_uc002qnd.3_Silent_p.K553K|ZNF667_uc010etm.3_Silent_p.K496K	NM_022103	NP_071386	Q5HYK9	ZN667_HUMAN	Homo sapiens zinc finger protein 667 (ZNF667), transcript variant 1, mRNA.	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		ATTCATAGGGTTTCTCTCCAG	0.408000														60			16		0	0	1	0	0
TTLL12	23170	broad.mit.edu	37	22	43565506	43565506	+	Splice_Site	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr22:43565506C>T	uc003bdq.3	-	12	1706	c.1644_splice	c.e12+1	p.Q548_splice	TTLL12_uc003bdp.3_Splice_Site_p.R141_splice|TTLL12_uc021wqu.1_Splice_Site	NM_015140	NP_055955	Q14166	TTL12_HUMAN	Homo sapiens tubulin tyrosine ligase-like family, member 12 (TTLL12), mRNA.	548	TTL.				protein modification process		tubulin-tyrosine ligase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	13		Ovarian(80;0.221)|Glioma(61;0.222)				CAGGAATTACCTGGACGTCCG	0.622000														81			15		0	0	1	0	0
ITGA3	3675	broad.mit.edu	37	17	48154412	48154412	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr17:48154412C>G	uc010dbm.3	+	14	2461	c.1997C>G	c.(1996-1998)tCc>tGc	p.S666C	ITGA3_uc010dbl.3_Missense_Mutation_p.S666C	NM_005501	NP_005492	P26006	ITA3_HUMAN	Homo sapiens integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), transcript variant b, mRNA.	666					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						TCGGAGCGCTCCGGGGAGGAC	0.687000														49			15		0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179437087	179437087	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:179437087A>G	uc021vsy.1	-	274	66293	c.66068T>C	c.(66067-66069)tTc>tCc	p.F22023S	MIR548N_uc021vsx.1_Intron|LOC100506866_uc002umo.3_Intron|LOC100506866_uc002ump.2_Intron|TTN_uc021vsz.1_Missense_Mutation_p.F15718S|TTN_uc021vta.1_Missense_Mutation_p.F15651S|TTN_uc021vtb.1_Missense_Mutation_p.F15526S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	22950	Ig-like 115.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGAACCCTGAAATAGTAGCT	0.448000														168			32		0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94046552	94046552	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr5:94046552A>C	uc003kkx.2	-	20	2801	c.2801T>G	c.(2800-2802)aTt>aGt	p.I934S	MCTP1_uc003kkv.2_Missense_Mutation_p.I713S|MCTP1_uc003kkw.2_Missense_Mutation_p.I627S|MCTP1_uc003kku.2_Missense_Mutation_p.I450S	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	Homo sapiens multiple C2 domains, transmembrane 1 (MCTP1), transcript variant L, mRNA.	934					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TCTCAGCGGAATGCAGTACAG	0.458000														42			15		0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34209065	34209065	+	Silent	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:34209065A>G	uc001bxm.1	-	13	2166	c.1989T>C	c.(1987-1989)atT>atC	p.I663I	CSMD2_uc001bxn.1_Silent_p.I623I	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	Homo sapiens CUB and Sushi multiple domains 2 (CSMD2), mRNA.	623	CUB 4.					integral to membrane|plasma membrane	protein binding	p.H662R(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTCCACGTCAATGTCGTTGA	0.602000														31			7		0	0	1	0	0
ATAT1	79969	broad.mit.edu	37	6	30594990	30594990	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr6:30594990A>G	uc003nqv.3	+	0	328	c.10A>G	c.(10-12)Acc>Gcc	p.T4A	ATAT1_uc003nqr.4_Intron|ATAT1_uc003nqs.4_Intron|ATAT1_uc003rdd.3_Intron|ATAT1_uc003rdc.3_Intron|ATAT1_uc011dmm.2_Missense_Mutation_p.T4A	NM_001031722	NP_001026892	Q5SQI0	ATAT_HUMAN	Homo sapiens alpha tubulin acetyltransferase 1 (ATAT1), transcript variant 1, mRNA.	0							tubulin N-acetyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	9						GATGTGGTTGACCTGGCCTTT	0.532000														81			5		0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16025181	16025181	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr19:16025181C>T	uc002nbu.2	-	11	1367	c.1331G>A	c.(1330-1332)cGt>cAt	p.R444H	CYP4F11_uc010eab.1_Silent_p.P422P|CYP4F11_uc002nbt.2_Missense_Mutation_p.R444H	NM_001128932	NP_067010	Q9HBI6	CP4FB_HUMAN	Homo sapiens cytochrome P450, family 4, subfamily F, polypeptide 11 (CYP4F11), transcript variant 2, mRNA.	444					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						TTGGTCGAAACGGAAGGGGTC	0.587000														62			21		0	0	1	0	0
AFTPH	54812	broad.mit.edu	37	2	64779179	64779179	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:64779179A>G	uc002sdc.3	+	0	603	c.571A>G	c.(571-573)Act>Gct	p.T191A	AFTPH_uc002scz.3_Missense_Mutation_p.T191A|AFTPH_uc002sda.3_Missense_Mutation_p.T191A|AFTPH_uc002sdb.3_Missense_Mutation_p.T191A	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	Homo sapiens aftiphilin (AFTPH), transcript variant 1, mRNA.	191					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						AGTGTTGGAAACTGTAAATCC	0.408000														106			4		0	0	1	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128886303	128886303	+	Silent	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chrX:128886303C>T	uc004eut.1	+	9	1243	c.999C>T	c.(997-999)atC>atT	p.I333I		NM_003399	NP_003390	O43895	XPP2_HUMAN	Homo sapiens X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (XPNPEP2), mRNA.	333					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						TGTATGGGATCTATGAAATGA	0.512000														27			29		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	116993	116993	+	RNA	SNP	T	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chrGL000205.1:116993T>C	uc002kgk.4	+	0		c.371T>C								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		TCACCTTAAATGGTTTTGAAC	0.483000														11			3		0	0	1	0	0
BRSK2	9024	broad.mit.edu	37	11	1466625	1466625	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr11:1466625G>A	uc001ltm.3	+	9	1305	c.1052G>A	c.(1051-1053)aGc>aAc	p.S351N	BRSK2_uc009ycv.1_Missense_Mutation_p.S305N|BRSK2_uc001lth.1_Missense_Mutation_p.S305N|BRSK2_uc001lti.3_Missense_Mutation_p.S305N|BRSK2_uc001ltl.3_Missense_Mutation_p.S305N|BRSK2_uc001ltj.3_Missense_Mutation_p.S305N|BRSK2_uc001ltk.3_Non-coding_Transcript|BRSK2_uc001ltn.3_Non-coding_Transcript|BRSK2_uc010qwx.2_Non-coding_Transcript	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	Homo sapiens BR serine/threonine kinase 2 (BRSK2), mRNA.	305					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(1)|lung(5)	10		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		GTGCTGGACAGCATGCACTCA	0.672000														36			4		0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30318485	30318485	+	Nonsense_Mutation	SNP	G	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr10:30318485G>A	uc009xle.2	-	2	729	c.592C>T	c.(592-594)Cag>Tag	p.Q198*	KIAA1462_uc001iux.3_Nonsense_Mutation_p.Q198*|KIAA1462_uc001iuy.3_Intron|KIAA1462_uc001iuz.3_Nonsense_Mutation_p.Q60*	NM_020848	NP_065899	Q9P266	K1462_HUMAN	Homo sapiens KIAA1462 (KIAA1462), mRNA.	198										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						TCAGACATCTGCCTCCCTAAT	0.483000														144			34		0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256530	115256530	+	Missense_Mutation	SNP	G	T	T	rs121913254		TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:115256530G>T	uc009wgu.3	-	2	435	c.181C>A	c.(181-183)Caa>Aaa	p.Q61K		NM_002524	NP_002515	P01111	RASN_HUMAN	Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), mRNA.	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		Ras protein signal transduction|activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61K(1229)|p.Q61R(898)|p.Q61L(198)|p.Q61H(123)|p.Q61P(23)|p.Q61E(18)|p.G60E(6)|p.Q61?(5)|p.Q61Q(3)|p.G60>?(2)|p.G60R(1)|p.Q61*(1)|p.Q61_E62>HK(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TACTCTTCTTGTCCAGCTGTA	0.458000	Q61K(CHP212_AUTONOMIC_GANGLIA)|Q61K(HCC15_LUNG)|Q61K(HS936T_SKIN)|Q61K(HS944T_SKIN)|Q61K(HT1080_SOFT_TISSUE)|Q61K(HUT78_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(M07E_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(NCIH1299_LUNG)|Q61K(NCIH2087_LUNG)|Q61K(OCILY19_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61K(SKNAS_AUTONOMIC_GANGLIA)|Q61K(SKNSH_AUTONOMIC_GANGLIA)|Q61K(TYKNU_OVARY)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)				31			41		1.02591e-13	1.1285e-13	1	1	0
SP2	6668	broad.mit.edu	37	17	46000417	46000417	+	Silent	SNP	C	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr17:46000417C>G	uc002imk.3	+	3	1286	c.1149C>G	c.(1147-1149)acC>acG	p.T383T	SP2_uc002iml.3_Silent_p.T376T	NM_003110	NP_003101	Q02086	SP2_HUMAN	Homo sapiens Sp2 transcription factor (SP2), mRNA.	383					immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|histone deacetylase binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	13						CTAACACCACCTGTAGCAGCC	0.607000														42			36		0	0	1	0	0
BAIAP2	10458	broad.mit.edu	37	17	79080558	79080558	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr17:79080558A>G	uc002jzg.2	+	11	1459	c.1351A>G	c.(1351-1353)Aag>Gag	p.K451E	BAIAP2_uc002jyz.4_Missense_Mutation_p.K451E|BAIAP2_uc002jza.2_Missense_Mutation_p.K451E|BAIAP2_uc002jzc.2_Missense_Mutation_p.K452E|BAIAP2_uc002jzb.2_Missense_Mutation_p.K208E|BAIAP2_uc010wuh.1_Missense_Mutation_p.K373E|BAIAP2_uc002jzd.2_Missense_Mutation_p.K451E|BAIAP2_uc002jzf.2_Missense_Mutation_p.K451E|BAIAP2_uc002jze.2_Missense_Mutation_p.K484E|BAIAP2_uc002jzh.2_Missense_Mutation_p.K452E|BAIAP2_uc010wui.2_Missense_Mutation_p.K314E	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	Homo sapiens BAI1-associated protein 2 (BAIAP2), transcript variant 2, mRNA.	451					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	SH3 domain binding|cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)	18	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCAGCAAGGGAAGAGCAGCAG	0.706000														79			4		0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83590705	83590705	+	Silent	SNP	C	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr7:83590705C>T	uc003uhz.3	-	16	2613	c.2298G>A	c.(2296-2298)agG>agA	p.R766R		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	Homo sapiens sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A (SEMA3A), mRNA.	766	Arg/Lys-rich (basic).				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						TCCTGGGTGCCCTCTCAAATT	0.433000														59			38		0	0	1	0	0
GPR161	23432	broad.mit.edu	37	1	168066296	168066296	+	Missense_Mutation	SNP	G	T	T			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr1:168066296G>T	uc010pln.2	-	3	1143	c.609C>A	c.(607-609)caC>caA	p.H203Q	GPR161_uc001gfb.3_Missense_Mutation_p.H51Q|GPR161_uc001gfc.3_Missense_Mutation_p.H183Q|GPR161_uc010pll.2_Missense_Mutation_p.H93Q|GPR161_uc010plm.2_Missense_Mutation_p.H69Q|GPR161_uc009wvo.3_Missense_Mutation_p.H200Q|GPR161_uc001gfd.3_Missense_Mutation_p.H183Q|GPR161_uc001gfe.1_Missense_Mutation_p.H183Q	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	Homo sapiens G protein-coupled receptor 161 (GPR161), transcript variant 2, mRNA.	183					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.L202L(1)		breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CAGGCTCCCGGTGCCAAGCAG	0.587000														32			37		1.96642e-18	2.27691e-18	1	1	0
GPR101	83550	broad.mit.edu	37	X	136112626	136112626	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chrX:136112626A>G	uc011mwh.2	-	0	1208	c.1208T>C	c.(1207-1209)aTc>aCc	p.I403T		NM_054021	NP_473362	Q96P66	GP101_HUMAN	Homo sapiens G protein-coupled receptor 101 (GPR101), mRNA.	403						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					GAAAATGATGATGAAGATCAC	0.552000														54			15		0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195510911	195510911	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr3:195510911G>A	uc021xjp.1	-	1	7696	c.7540C>T	c.(7540-7542)Cct>Tct	p.P2514S	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	273					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TCGGTGACAGGTAGAGGGGTG	0.557000														331			9		0	0	1	0	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158611	26158611	+	Missense_Mutation	SNP	G	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr6:26158611G>C	uc003ngr.3	+	0	263	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	HIST1H2BD_uc003ngs.3_Missense_Mutation_p.E72Q	NM_021063	NP_619790	P58876	H2B1D_HUMAN	Homo sapiens histone cluster 1, H2bd (HIST1H2BD), transcript variant 1, mRNA.	72					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	24						CGACATCTTCGAGCGCATCGC	0.587000														108			5		0	0	1	0	0
FOXN2	3344	broad.mit.edu	37	2	48602092	48602092	+	Frame_Shift_Del	DEL	A	-	-	rs149269949		TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:48602092delA	uc002rwh.1	+	6	1121	c.806delA	c.(805-807)caafs	p.Q269fs		NM_002158	NP_002149	P32314	FOXN2_HUMAN	Homo sapiens forkhead box N2 (FOXN2), mRNA.	269					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			ACAGCATTGCAAAAAAAGAGG	0.383													---	288	---	---	7	---					
RIF1	55183	broad.mit.edu	37	2	152293790	152293790	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr2:152293790delT	uc002txm.3	+	12	1569	c.1408delT	c.(1408-1410)tttfs	p.F470fs	RIF1_uc010fnv.2_Frame_Shift_Del_p.F434fs|RIF1_uc002txn.3_Frame_Shift_Del_p.F470fs|RIF1_uc002txl.3_Frame_Shift_Del_p.F470fs|RIF1_uc002txo.3_Frame_Shift_Del_p.F470fs|RIF1_uc010zby.1_Non-coding_Transcript	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	Homo sapiens RAP1 interacting factor homolog (yeast) (RIF1), transcript variant 1, mRNA.	470					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CAGCCCTTCCTTTTTTTCCAA	0.343													---	451	---	---	7	---					
NOM1	64434	broad.mit.edu	37	7	156752565	156752567	+	In_Frame_Del	DEL	GGC	-	-			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr7:156752565_156752567delGGC	uc003wmy.3	+	3	1344_1346	c.1329_1331delGGC	c.(1327-1332)gaggca>gaa	p.A444del	NOM1_uc010lqp.1_5'Flank	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	Homo sapiens nucleolar protein with MIF4G domain 1 (NOM1), mRNA.	444	MIF4G.				RNA metabolic process	nucleolus	protein binding			endometrium(5)|kidney(4)|large_intestine(9)|lung(7)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		ACTTTCTGGAGGCAGTGGTGAGG	0.448													---	55	---	---	19	---					
NOM1	64434	broad.mit.edu	37	7	156752569	156752570	+	Frame_Shift_Del	DEL	GT	-	-			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr7:156752569_156752570delGT	uc003wmy.3	+	3	1348_1349	c.1333_1334delGT	c.(1333-1335)gtgfs	p.V445fs	NOM1_uc010lqp.1_5'Flank	NM_138400	NP_612409	Q5C9Z4	NOM1_HUMAN	Homo sapiens nucleolar protein with MIF4G domain 1 (NOM1), mRNA.	445	MIF4G.				RNA metabolic process	nucleolus	protein binding			endometrium(5)|kidney(4)|large_intestine(9)|lung(7)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31	Ovarian(565;0.218)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00301)	UCEC - Uterine corpus endometrioid carcinoma (81;0.169)		TCTGGAGGCAGTGGTGAGGAAG	0.450													---	55	---	---	19	---					
PABPC1	26986	broad.mit.edu	37	8	101724623	101724624	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr8:101724623_101724624insA	uc003yjs.1	-	6	1442_1443	c.938_939insT	c.(937-939)gagfs	p.E313fs	PABPC1_uc011lhc.1_Frame_Shift_Ins_p.E281fs|PABPC1_uc011lhd.1_Frame_Shift_Ins_p.E268fs|PABPC1_uc003yjt.1_Frame_Shift_Ins_p.E310fs|PABPC1_uc003yju.2_Non-coding_Transcript	NM_002568	NP_002559	P11940	PABP1_HUMAN	Homo sapiens poly(A) binding protein, cytoplasmic 1 (PABPC1), mRNA.	313	RRM 4.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			ATGGAGAAAACTCTTTCCGGAG	0.297													---	343	---	---	7	---					
PABPC1	26986	broad.mit.edu	37	8	101724626	101724627	+	Frame_Shift_Del	DEL	TT	-	-			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr8:101724626_101724627delTT	uc003yjs.1	-	6	1439_1440	c.935_936delAA	c.(934-936)aaafs	p.K312fs	PABPC1_uc011lhc.1_Frame_Shift_Del_p.K280fs|PABPC1_uc011lhd.1_Frame_Shift_Del_p.K267fs|PABPC1_uc003yjt.1_Frame_Shift_Del_p.K309fs|PABPC1_uc003yju.2_Non-coding_Transcript	NM_002568	NP_002559	P11940	PABP1_HUMAN	Homo sapiens poly(A) binding protein, cytoplasmic 1 (PABPC1), mRNA.	312	RRM 4.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity	p.R311R(1)		breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			GAGAAAACTCTTTCCGGAGACG	0.307													---	341	---	---	7	---					
C10orf114	399726	broad.mit.edu	37	10	21784654	21784655	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr10:21784654_21784655insC	uc001iqn.4	-	1	755_756	c.285_286insG	c.(283-288)gggcctfs	p.G95fs		NM_001010911	NP_001010911	Q5T4H9	CJ114_HUMAN	Homo sapiens chromosome 10 open reading frame 114 (C10orf114), mRNA.	95										endometrium(2)|large_intestine(1)|lung(2)	5						GGACGGTCAGGCCCGCCGCTAC	0.668											OREG0020066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	46	---	---	8	---					
MUC5B	727897	broad.mit.edu	37	11	1271712	1271713	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr11:1271712_1271713insC	uc001lta.3	+	30	13661_13662	c.13602_13603insC	c.(13600-13605)tggaccfs	p.W4534fs		NM_002458	NP_002449	Q9HC84	MUC5B_HUMAN	Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.	4534	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCACCACCTGGACCCGCCTATC	0.624													---	172	---	---	7	---					
LUZP2	338645	broad.mit.edu	37	11	24936024	24936024	+	Frame_Shift_Del	DEL	A	-	-	rs140841896		TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr11:24936024delA	uc001mqs.3	+	6	736	c.462delA	c.(460-462)tcafs	p.S154fs	LUZP2_uc009yif.3_Frame_Shift_Del_p.S68fs|LUZP2_uc009yig.3_Intron	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	Homo sapiens leucine zipper protein 2 (LUZP2), transcript variant 1, mRNA.	154						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						CCTTACAGTCAAAAAAAATCC	0.348													---	128	---	---	9	---					
ALG10B	144245	broad.mit.edu	37	12	38714025	38714025	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr12:38714025delT	uc001rln.4	+	2	571	c.432delT	c.(430-432)tatfs	p.Y144fs		NM_001013620	NP_001013642	Q5I7T1	AG10B_HUMAN	Homo sapiens asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast) (ALG10B), mRNA.	144					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				CAACACTTTATTTTTTTAACT	0.318													---	422	---	---	9	---					
ZNF563	147837	broad.mit.edu	37	19	12433413	12433423	+	Frame_Shift_Del	DEL	TTCCTGATGGT	-	-			TCGA-KN-8427-01A-11D-2310-10	TCGA-KN-8427-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	07e0e938-f61f-477a-92a2-5b7e74b78943	8c9e2ce1-0c90-49e7-a0ea-0ac0efcb7f6b	g.chr19:12433413_12433423delTTCCTGATGGT	uc002mtp.3	-	1	344_354	c.106_116delACCATCAGGAA	c.(106-117)accatcaggaacfs	p.T36fs	ZNF563_uc002mtq.2_Frame_Shift_Del_p.T36fs	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	Homo sapiens zinc finger protein 563 (ZNF563), mRNA.	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R38R(2)		breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						ACAGTCCAGGTTCCTGATGGTTTCTTGCATC	0.417													---	80	---	---	13	---					
