Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LOC220729	220729	broad.mit.edu	37	3	197348716	197348716	+	RNA	SNP	A	C	C			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr3:197348716A>C	uc011bug.2	-	3		c.375T>G			LOC220729_uc003fxy.3_Non-coding_Transcript|LOC220729_uc010iao.2_Intron					Homo sapiens succinate dehydrogenase complex, subunit A, flavoprotein (Fp) pseudogene (LOC220729), non-coding RNA.																		CAGTTCTGCTAAACGGCATGC	0.433000														64			50		0	0	1	0	0
KIAA1731	85459	broad.mit.edu	37	11	93462806	93462806	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr11:93462806C>T	uc009ywb.1	+	26	7577	c.7426C>T	c.(7426-7428)Cca>Tca	p.P2476S	KIAA1731_uc001pdu.1_Missense_Mutation_p.P656S|KIAA1731_uc001pdw.1_Missense_Mutation_p.P489S|KIAA1731_uc001pdx.1_Missense_Mutation_p.P343S	NM_033395	NP_203753	Q9C0D2	K1731_HUMAN	Homo sapiens KIAA1731 (KIAA1731), mRNA.	2476						centrosome				breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)	11		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TACACCTGTACCAGGGAGCTT	0.413000														88			5		0	0	1	0	0
ATP8B2	57198	broad.mit.edu	37	1	154315638	154315638	+	Silent	SNP	C	T	T			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr1:154315638C>T	uc001fex.3	+	15	1602	c.1602C>T	c.(1600-1602)acC>acT	p.T534T		NM_020452	NP_065185	P98198	AT8B2_HUMAN	Homo sapiens ATPase, class I, type 8B, member 2 (ATP8B2), transcript variant 1, mRNA.	520					ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity		IL6R/ATP8B2(2)	breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCCTGGTCACCGCAGCCAGGA	0.567000														86			9		0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587779	55587779	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr11:55587779C>T	uc010rin.2	+	0	674	c.674C>T	c.(673-675)aCc>aTc	p.T225I		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily D, member 18 (OR5D18), mRNA.	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				ATTGTTGTAACCATCCTCAAG	0.488000														177			17		0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	37136306	37136306	+	Silent	SNP	T	C	C			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr7:37136306T>C	uc022abv.1	-	14	1928	c.1218A>G	c.(1216-1218)gaA>gaG	p.E406E	ELMO1_uc011kbc.2_Silent_p.E310E|ELMO1_uc003tfk.2_Silent_p.E406E|ELMO1_uc010kxg.2_Silent_p.E406E	NM_001206482	NP_001193411	Q92556	ELMO1_HUMAN	Homo sapiens engulfment and cell motility 1 (ELMO1), transcript variant 5, mRNA.	406	ELMO.				Rac protein signal transduction|actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						CATGCTTGTCTTCTCGACTAC	0.408000														165			4		0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195509691	195509691	+	Silent	SNP	T	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr3:195509691T>A	uc021xjp.1	-	1	8916	c.8760A>T	c.(8758-8760)tcA>tcT	p.S2920S	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	668					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CTGTGGATGCTGAGGAAGTGT	0.577000														151			4		0	0	1	0	0
ZNF653	115950	broad.mit.edu	37	19	11598244	11598244	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr19:11598244A>G	uc002mrz.2	-	3	1171	c.1034T>C	c.(1033-1035)gTc>gCc	p.V345A		NM_138783	NP_620138	Q96CK0	ZN653_HUMAN	Homo sapiens zinc finger protein 653 (ZNF653), mRNA.	345					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G344C(1)		endometrium(2)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	17						ACTGCCGGGGACACCGCTGCC	0.652000														34			3		0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113333605	113333605	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr12:113333605C>G	uc010syl.2	+	20	2243	c.1881C>G	c.(1879-1881)caC>caG	p.H627Q	RPH3A_uc001ttz.3_Missense_Mutation_p.H627Q|RPH3A_uc001tty.3_Missense_Mutation_p.H623Q|RPH3A_uc010sym.2_Missense_Mutation_p.H578Q|RPH3A_uc001tua.3_Missense_Mutation_p.H387Q	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	Homo sapiens rabphilin 3A homolog (mouse) (RPH3A), transcript variant 1, mRNA.	627	C2 2.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding	p.A627T(1)		breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ACATCAAACACAGTGACCTGG	0.468000														52			39		0	0	1	0	0
BCKDHA	593	broad.mit.edu	37	19	41884219	41884219	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr19:41884219A>G	uc002oqm.4	+	1	356	c.5A>G	c.(4-6)gAc>gGc	p.D2G	BCKDHA_uc002oqi.3_Missense_Mutation_p.D2G|BCKDHA_uc010ehq.3_Missense_Mutation_p.D2G|BCKDHA_uc010ehr.3_Missense_Mutation_p.D2G|BCKDHA_uc002oqk.4_Missense_Mutation_p.D2G|BCKDHA_uc010eht.3_Missense_Mutation_p.D2G|BCKDHA_uc010ehs.3_Missense_Mutation_p.D2G|BCKDHA_uc002oqn.3_Missense_Mutation_p.D2G	NM_000709	NP_000700	P12694	ODBA_HUMAN	Homo sapiens branched chain keto acid dehydrogenase E1, alpha polypeptide (BCKDHA), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	0					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	10						AAAGCCATGGACAGCCCTAGT	0.557000														109			4		0	0	1	0	0
FBXO16	157574	broad.mit.edu	37	8	28321189	28321189	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr8:28321189C>A	uc003xgu.3	-	3	380	c.282G>T	c.(280-282)agG>agT	p.R94S	ZNF395_uc003xgt.3_5'UTR|FBXO16_uc003xgv.3_Missense_Mutation_p.R81S	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	Homo sapiens F-box protein 16 (FBXO16), mRNA.	94	F-box.									large_intestine(2)|ovary(1)	3		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		AAGATAACACCCTTGGAAGCT	0.483000														158			5		2.7689e-08	2.86779e-08	1	1	0
C4orf17	84103	broad.mit.edu	37	4	100460404	100460404	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr4:100460404A>C	uc003huw.3	+	6	1075	c.713A>C	c.(712-714)gAa>gCa	p.E238A	C4orf17_uc003hux.3_Non-coding_Transcript	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	Homo sapiens chromosome 4 open reading frame 17 (C4orf17), mRNA.	238										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|urinary_tract(3)	18				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		ACCTCAATGGAACCAGCAGCA	0.428000														240			6		0	0	1	0	0
ENTPD5	957	broad.mit.edu	37	14	74443082	74443082	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr14:74443082C>T	uc010tuo.2	-	8	898	c.587G>A	c.(586-588)gGg>gAg	p.G196E	ENTPD5_uc001xpi.3_Missense_Mutation_p.G196E	NM_001249	NP_001240	O75356	ENTP5_HUMAN	Homo sapiens ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5), mRNA.	196					'de novo' posttranslational protein folding|ATP metabolic process|cell growth|cell proliferation|glycolysis|protein N-linked glycosylation|regulation of phosphatidylinositol 3-kinase cascade	endoplasmic reticulum lumen	guanosine-diphosphatase activity|uridine-diphosphatase activity	p.G196W(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	10				BRCA - Breast invasive adenocarcinoma(234;0.00394)		GTCCAAGGTCCCCACAGTCTC	0.542000														90			4		0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41585844	41585844	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr17:41585844A>G	uc002idu.1	+	15	2530	c.2458A>G	c.(2458-2460)Atg>Gtg	p.M820V	DHX8_uc010wif.1_Missense_Mutation_p.M729V|DHX8_uc010wig.2_Missense_Mutation_p.M820V	NM_004941	NP_004932	Q14562	DHX8_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 8 (DHX8), mRNA.	820	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|RNA binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		TCCCAGTGAGATGCAGACCCG	0.478000														79			4		0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107154198	107154198	+	Silent	SNP	A	G	G	rs149535149		TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr4:107154198A>G	uc010ilv.2	-	16	1901	c.1536T>C	c.(1534-1536)tgT>tgC	p.C512C	TBCK_uc003hyb.2_Silent_p.C255C|TBCK_uc003hye.2_Silent_p.C473C|TBCK_uc003hyc.2_Silent_p.C449C|TBCK_uc003hyd.2_Silent_p.C340C|TBCK_uc003hyf.2_Silent_p.C512C	NM_001163435	NP_001156908	Q8TEA7	TBCK_HUMAN	Homo sapiens TBC1 domain containing kinase (TBCK), transcript variant 1, mRNA.	512	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						CGTACTGATGACAGCGAGGAA	0.363000														119			4		0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115973824	115973824	+	Silent	SNP	T	C	C			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr10:115973824T>C	uc001lbg.1	+	15	2316	c.2163T>C	c.(2161-2163)tgT>tgC	p.C721C	TDRD1_uc001lbf.3_Silent_p.C655C|TDRD1_uc001lbh.1_Silent_p.C712C|TDRD1_uc001lbi.1_Silent_p.C712C|TDRD1_uc010qsc.2_Silent_p.C325C|TDRD1_uc001lbj.3_Silent_p.C430C	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	Homo sapiens tudor domain containing 1 (TDRD1), mRNA.	721					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TTGTGGTCTGTGTGATATATA	0.373000														105			4		0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138437565	138437565	+	Missense_Mutation	SNP	C	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr7:138437565C>G	uc003vuf.3	-	9	1072	c.834G>C	c.(832-834)gaG>gaC	p.E278D	ATP6V0A4_uc003vug.3_Missense_Mutation_p.E278D|ATP6V0A4_uc003vuh.3_Missense_Mutation_p.E278D	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal V0 subunit a4 (ATP6V0A4), transcript variant 3, mRNA.	278					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GGCGGTGAGACTCTGTTTGTG	0.498000														79			64		0	0	1	0	0
CLCC1	23155	broad.mit.edu	37	1	109486125	109486125	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr1:109486125A>C	uc021ora.1	-	4	685	c.674T>G	c.(673-675)tTg>tGg	p.L225W	AKNAD1_uc010ovb.2_Intron|CLCC1_uc001dwg.1_Missense_Mutation_p.L175W|CLCC1_uc001dwf.1_Missense_Mutation_p.L225W|CLCC1_uc009wes.1_Intron|CLCC1_uc009wet.1_Intron|CLCC1_uc001dwh.1_Missense_Mutation_p.L225W	NM_001048210	NP_001041675	Q96S66	CLCC1_HUMAN	Homo sapiens chloride channel CLIC-like 1 (CLCC1), transcript variant 1, mRNA.	225						Golgi apparatus|endoplasmic reticulum|integral to membrane|nucleus				autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|liver(1)|skin(1)	14		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.231)		ATTCCATCCCAAACTGAACAG	0.368000														129			4		0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189526226	189526226	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr3:189526226G>A	uc003fry.2	+	3	579	c.490G>A	c.(490-492)Gcc>Acc	p.A164T	TP63_uc003frx.2_Missense_Mutation_p.A164T|TP63_uc003frz.2_Missense_Mutation_p.A164T|TP63_uc010hzc.1_Missense_Mutation_p.A164T|TP63_uc003fsa.2_Missense_Mutation_p.A70T|TP63_uc003fsb.2_Missense_Mutation_p.A70T|TP63_uc003fsc.2_Missense_Mutation_p.A70T|TP63_uc003fsd.2_Missense_Mutation_p.A70T|TP63_uc021xir.1_Missense_Mutation_p.A70T|TP63_uc010hzd.1_Intron|TP63_uc003fse.1_Missense_Mutation_p.A45T	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	Homo sapiens tumor protein p63 (TP63), transcript variant 1, mRNA.	164					DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|Notch signaling pathway|anti-apoptosis|cellular response to UV|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to X-ray|response to gamma radiation	Golgi apparatus|chromatin|cytosol|dendrite|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TCCATCACCCGCCATCCCCTC	0.637000										HNSCC(45;0.13)				169			9		0	0	1	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138437566	138437566	+	Missense_Mutation	SNP	T	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr7:138437566T>A	uc003vuf.3	-	9	1071	c.833A>T	c.(832-834)gAg>gTg	p.E278V	ATP6V0A4_uc003vug.3_Missense_Mutation_p.E278V|ATP6V0A4_uc003vuh.3_Missense_Mutation_p.E278V	NM_130841	NP_570856	Q9HBG4	VPP4_HUMAN	Homo sapiens ATPase, H+ transporting, lysosomal V0 subunit a4 (ATP6V0A4), transcript variant 3, mRNA.	278					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GCGGTGAGACTCTGTTTGTGT	0.498000														79			65		0	0	1	0	0
HDAC11	79885	broad.mit.edu	37	3	13544436	13544436	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr3:13544436A>G	uc003bxy.3	+	7	738	c.605A>G	c.(604-606)gAt>gGt	p.D202G	HDAC11_uc010heb.3_Missense_Mutation_p.M160V|HDAC11_uc011aux.2_Missense_Mutation_p.D10G|HDAC11_uc011auy.2_Missense_Mutation_p.D151G	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	Homo sapiens histone deacetylase 11 (HDAC11), transcript variant 1, mRNA.	202	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|histone deacetylase activity (H3-K16 specific)|transcription factor binding			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(4)|prostate(3)	13						TACATCATGGATGTCTACAAC	0.582000														63			20		0	0	1	0	0
AGBL4	84871	broad.mit.edu	37	1	50162981	50162981	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr1:50162981T>C	uc010omx.1	-	2	444	c.286A>G	c.(286-288)Agg>Ggg	p.R96G	AGBL4_uc001cru.2_Intron|AGBL4_uc010omw.1_Intron	NM_032785	NP_116174	Q5VU57	CBPC6_HUMAN	Homo sapiens ATP/GTP binding protein-like 4 (AGBL4), mRNA.	94					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)	15				Colorectal(2;0.00349)|COAD - Colon adenocarcinoma(2;0.0037)		ACTATTTCCCTCACCTGTGAT	0.348000														155			4		0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73205262	73205262	+	Silent	SNP	A	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr4:73205262A>G	uc003hgk.2	-	4	847	c.810T>C	c.(808-810)cgT>cgC	p.R270R		NM_014243	NP_055058	O15072	ATS3_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 3 (ADAMTS3), mRNA.	270	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding	p.R270S(1)|p.R270C(1)		NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGCCATGGAAACGGACCACAG	0.453000														159			6		0	0	1	0	0
EPB42	2038	broad.mit.edu	37	15	43499534	43499534	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr15:43499534A>G	uc001zrb.4	-	8	1571	c.1271T>C	c.(1270-1272)gTg>gCg	p.V424A	EPB42_uc001zqz.4_Missense_Mutation_p.V61A|EPB42_uc001zra.4_Missense_Mutation_p.V394A|EPB42_uc010udm.2_Missense_Mutation_p.V316A	NM_000119	NP_000110	P16452	EPB42_HUMAN	Homo sapiens erythrocyte membrane protein band 4.2 (EPB42), transcript variant 1, mRNA.	394					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		CTTCCAGACCACACATGAGGC	0.562000														153			4		0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540071	169540071	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr3:169540071G>A	uc003fgb.3	+	0	362	c.362G>A	c.(361-363)cGc>cAc	p.R121H		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	Homo sapiens leucine-rich repeats and IQ motif containing 4 (LRRIQ4), mRNA.	121										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						CACGCCCTGCGCGAGCTCCGG	0.607000														36			28		0	0	1	0	0
PPP1R3B	79660	broad.mit.edu	37	8	8998708	8998708	+	Nonsense_Mutation	SNP	G	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr8:8998708G>A	uc022arp.1	-	0	454	c.454C>T	c.(454-456)Cag>Tag	p.Q152*	PPP1R3B_uc003wsn.4_Nonsense_Mutation_p.Q152*|PPP1R3B_uc003wso.4_Nonsense_Mutation_p.Q152*	NM_024607	NP_078883	Q86XI6	PPR3B_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 3B (PPP1R3B), transcript variant 2, mRNA.	152	CBM21.				glycogen metabolic process					endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	12				COAD - Colon adenocarcinoma(149;0.0717)|READ - Rectum adenocarcinoma(644;0.241)		GCGAGGTTCTGAACCTTCACA	0.478000														101			74		0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	421030	421030	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr11:421030C>T	uc001lpi.2	-	16	1490	c.1405G>A	c.(1405-1407)Ggc>Agc	p.G469S	ANO9_uc001lph.2_Missense_Mutation_p.G162S|ANO9_uc010qvv.1_Missense_Mutation_p.G325S	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	Homo sapiens anoctamin 9 (ANO9), mRNA.	469						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						ATCATGCAGCCGCTGGCGTGG	0.657000														75			3		0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	93963546	93963546	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr14:93963546C>A	uc001ybv.1	+	3	364	c.281C>A	c.(280-282)cCt>cAt	p.P94H	UNC79_uc001ybs.1_Missense_Mutation_p.P94H|UNC79_uc001ybu.1_Intron	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	Homo sapiens unc-79 homolog (C. elegans) (UNC79), mRNA.	271						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CAAGTGAAGCCTCCAGCTGTG	0.438000														80			5		1.23904e-05	1.23904e-05	1	1	0
RASGRF1	5923	broad.mit.edu	37	15	79324635	79324635	+	Missense_Mutation	SNP	G	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr15:79324635G>A	uc002beq.3	-	6	1357	c.982C>T	c.(982-984)Ccc>Tcc	p.P328S	RASGRF1_uc002bep.3_Missense_Mutation_p.P328S|RASGRF1_uc010blm.1_Missense_Mutation_p.P250S|RASGRF1_uc002ber.4_Missense_Mutation_p.P328S	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Homo sapiens Ras protein-specific guanine nucleotide-releasing factor 1 (RASGRF1), transcript variant 1, mRNA.	328	DH.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TTGAGCATGGGCAGCAGGATG	0.587000														183			128		0	0	1	0	0
CCDC168	643677	broad.mit.edu	37	13	103393537	103393537	+	Missense_Mutation	SNP	C	A	A			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr13:103393537C>A	uc001vpm.3	-	3	9650	c.9510G>T	c.(9508-9510)atG>atT	p.M3170I		NM_001146197	NP_001139669			Homo sapiens coiled-coil domain containing 168 (CCDC168), mRNA.																		TTGAAAAGTCCATTTTCTGTC	0.294000														18			49		2.01807e-28	2.16756e-28	1	1	0
AGRN	375790	broad.mit.edu	37	1	983488	983489	+	In_Frame_Ins	INS	-	CCA	CCA			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr1:983488_983489insCCA	uc001ack.2	+	22	3898_3899	c.3848_3849insCCA	c.(3847-3849)gct>gcCCAt	p.1283_1284insH		NM_198576	NP_940978	O00468	AGRIN_HUMAN	Homo sapiens agrin (AGRN), mRNA.	1283	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCGTCCTCTGCTGTGACCCCTC	0.698													---	4	---	---	2	---					
AGRN	375790	broad.mit.edu	37	1	983491	983493	+	In_Frame_Del	DEL	TGA	-	-			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr1:983491_983493delTGA	uc001ack.2	+	22	3901_3903	c.3851_3853delTGA	c.(3850-3855)gtgacc>gcc	p.1284_1285VT>A		NM_198576	NP_940978	O00468	AGRIN_HUMAN	Homo sapiens agrin (AGRN), mRNA.	1284	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		TCCTCTGCTGTGACCCCTCGGGC	0.695													---	4	---	---	2	---					
TERT	7015	broad.mit.edu	37	5	1294102	1294102	+	Frame_Shift_Del	DEL	C	-	-			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr5:1294102delC	uc003jcb.1	-	1	957	c.899delG	c.(898-900)ggcfs	p.G300fs	TERT_uc003jcc.1_Frame_Shift_Del_p.G300fs|TERT_uc003jca.1_Frame_Shift_Del_p.G300fs|TERT_uc003jcd.1_Non-coding_Transcript|TERT_uc003jce.1_Non-coding_Transcript|TERT_uc021xwa.1_Intron|TERT_uc021xwb.1_Intron|TERT_uc021xwc.1_Intron	NM_198253	NP_937983	O14746	TERT_HUMAN	Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 1, mRNA.	300	Linker.				DNA strand elongation|anti-apoptosis|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	PML body|cytoplasm|nucleolus|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity	p.V299L(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GTGCTGGCGGCCCACGGATGG	0.677									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				---	4	---	---	2	---					
FLJ35390	255031	broad.mit.edu	37	7	44081007	44081007	+	RNA	DEL	G	-	-	rs71011964		TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr7:44081007delG	uc003tjk.2	+	1		c.1700delG			RASA4_uc003tji.2_5'Flank|RASA4_uc010kxx.2_5'Flank|RASA4_uc011kbk.1_5'Flank|FLJ35390_uc003tjl.4_Intron|FLJ35390_uc011kbl.2_Non-coding_Transcript					Homo sapiens uncharacterized LOC255031 (FLJ35390), transcript variant 1, non-coding RNA.																		ACATTCTTTTGGGGGGGGGGG	0.547													---	4	---	---	2	---					
MUC6	4588	broad.mit.edu	37	11	1018550	1018551	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr11:1018550_1018551insG	uc001lsw.2	-	30	4301_4302	c.4250_4251insC	c.(4249-4251)cctfs	p.P1417fs		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	Homo sapiens mucin 6, oligomeric mucus/gel-forming (MUC6), mRNA.	1417	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACCTGTGGAAGGGACGGGACT	0.559													---	432	---	---	9	---					
MLNR	2862	broad.mit.edu	37	13	49794805	49794805	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr13:49794805delG	uc010tgj.2	+	0	332	c.332delG	c.(331-333)tgcfs	p.C111fs		NM_001507	NP_001498	O43193	MTLR_HUMAN	Homo sapiens motilin receptor (MLNR), mRNA.	111					digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity			endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)	14		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CCGCTGCTCTGCCGCCTGTCC	0.706													---	4	---	---	2	---					
ANKRD30B	374860	broad.mit.edu	37	18	14837637	14837637	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KN-8429-01A-11D-2310-10	TCGA-KN-8429-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	58c7e9c3-1345-48c0-a758-0887358b8696	8a9aade0-01c0-49a8-9a47-1498341edff7	g.chr18:14837637delG	uc010dlo.2	+	29	2773	c.2593delG	c.(2593-2595)ggafs	p.G865fs	ANKRD30B_uc021uhy.1_Frame_Shift_Del_p.G865fs|ANKRD30B_uc010xal.1_Frame_Shift_Del_p.G7fs	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	Homo sapiens ankyrin repeat domain 30B (ANKRD30B), mRNA.	950										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ATCAGAATTAGGAAGAAAAGA	0.264													---	454	---	---	7	---					
