Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCRIB	23513	broad.mit.edu	37	8	144890886	144890886	+	Nonsense_Mutation	SNP	G	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr8:144890886G>A	uc003yzp.1	-	14	2015	c.2008C>T	c.(2008-2010)Cag>Tag	p.Q670*	SCRIB_uc003yzo.1_Nonsense_Mutation_p.Q670*	NM_015356	NP_056171	Q14160	SCRIB_HUMAN	Homo sapiens scribbled homolog (Drosophila) (SCRIB), transcript variant 2, mRNA.	670	Glu-rich.|Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	Scrib-APC-beta-catenin complex|cell-cell adherens junction	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			tcctcctcctgaggactaccc	0.667000														58			5		0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579699	7579699	+	Splice_Site	SNP	C	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr17:7579699C>A	uc002gim.2	-	3	290	c.96_splice	c.e3+1	p.L32_splice	TP53_uc002gig.1_Splice_Site_p.L32_splice|TP53_uc002gih.3_Splice_Site_p.L32_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cni.1_Splice_Site_p.L32_splice|TP53_uc010cnh.1_Splice_Site_p.L32_splice|TP53_uc002gij.2_Splice_Site_p.L32_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Splice_Site_p.L32_splice|TP53_uc002gio.2_Intron|TP53_uc010vug.2_Splice_Site|TP53_uc010cnk.1_Splice_Site_p.L47_splice	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	32	Interaction with HRMT1L2.|Transcription activation (acidic).				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.0?(8)|p.S33fs*10(1)|p.P13fs*18(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTGTCCTTACCAGAACGTTG	0.597000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)				31			16		2.41591e-17	2.7179e-17	1	1	0
CHUK	1147	broad.mit.edu	37	10	101969426	101969426	+	Nonsense_Mutation	SNP	G	A	A	rs5787373		TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr10:101969426G>A	uc001kqp.3	-	9	1109	c.1054C>T	c.(1054-1056)Caa>Taa	p.Q352*		NM_001278	NP_001269	O15111	IKKA_HUMAN	Homo sapiens conserved helix-loop-helix ubiquitous kinase (CHUK), mRNA.	352					I-kappaB phosphorylation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|T cell receptor signaling pathway|Toll signaling pathway|innate immune response|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|IkappaB kinase activity|identical protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		AGAAGTTCTTGAGAACCAGTA	0.373000														29			29		0	0	1	0	0
NACAD	23148	broad.mit.edu	37	7	45123697	45123697	+	Silent	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr7:45123697C>T	uc003tmt.3	-	1	2082	c.2082G>A	c.(2080-2082)tcG>tcA	p.S694S		NM_001146334	NP_001139806	O15069	NACAD_HUMAN	Homo sapiens NAC alpha domain containing (NACAD), mRNA.	694					protein transport	cytoplasm|nucleus				breast(1)|endometrium(2)|skin(2)	5						TTGGGGCTGACGAGAGATCTG	0.632000														7			4		0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132919192	132919192	+	RNA	SNP	G	A	A	rs111295191		TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr2:132919192G>A	uc002tti.3	-	0		c.334C>T			ANKRD30BL_uc002ttj.3_Intron					Homo sapiens ankyrin repeat domain 30B-like (ANKRD30BL), transcript variant 1, non-coding RNA.											endometrium(1)|kidney(3)	4						CGTAAGAGTCGTTGTTGGTGT	0.602000														128			10		0	0	1	0	0
RUNX2	860	broad.mit.edu	37	6	45405707	45405707	+	Missense_Mutation	SNP	A	G	G			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr6:45405707A>G	uc011dvx.2	+	4	814	c.604A>G	c.(604-606)Acc>Gcc	p.T202A	RUNX2_uc011dvy.2_Missense_Mutation_p.T202A|RUNX2_uc003oxt.3_Missense_Mutation_p.T188A	NM_001024630	NP_001019801	Q13950	RUNX2_HUMAN	Homo sapiens runt-related transcription factor 2 (RUNX2), transcript variant 1, mRNA.	202	Runt.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CTTGACCATAACCGTCTTCAC	0.398000														61			29		0	0	1	0	0
MRPS12	6183	broad.mit.edu	37	19	39421914	39421914	+	Splice_Site	SNP	A	G	G			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr19:39421914A>G	uc002okc.3	+	2	292	c.-18_splice	c.e2-2		SARS2_uc002ojz.2_5'Flank|SARS2_uc010xup.1_5'Flank|SARS2_uc002oka.2_5'Flank|SARS2_uc010xuq.1_Intron|SARS2_uc010xur.1_5'Flank|SARS2_uc010xus.1_5'Flank|MRPS12_uc002okd.3_Splice_Site|MRPS12_uc002oke.3_5'UTR	NM_033362	NP_203527	O15235	RT12_HUMAN	Homo sapiens mitochondrial ribosomal protein S12 (MRPS12), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA.						translation	mitochondrial ribosome|small ribosomal subunit	protein binding|structural constituent of ribosome			endometrium(1)|large_intestine(1)	2	all_cancers(60;8.37e-07)|all_lung(34;3.71e-07)|Lung NSC(34;4.17e-07)|all_epithelial(25;1.13e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CCCCTACCACAGGGACGGCCC	0.547000														94			4		0	0	1	0	0
TAPBPL	55080	broad.mit.edu	37	12	6567817	6567817	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr12:6567817C>T	uc001qog.4	+	4	1149	c.911C>T	c.(910-912)cCt>cTt	p.P304L	TAPBPL_uc001qoi.1_Non-coding_Transcript	NM_018009	NP_060479	Q9BX59	TPSNR_HUMAN	Homo sapiens TAP binding protein-like (TAPBPL), mRNA.	304	Ig-like C1-type.				antigen processing and presentation of endogenous peptide antigen via MHC class I	endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane				endometrium(2)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	6						CCAGCTTCCCCTAAAGTACGA	0.517000														62			3		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117785	117785	+	RNA	SNP	C	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chrGL000205.1:117785C>A	uc002kgk.4	+	0		c.1163C>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		AAGGCCTTTGCAGGATGGGAT	0.567000														26			10		5.16669e-11	5.58002e-11	1	1	0
C7orf63	79846	broad.mit.edu	37	7	89937126	89937126	+	Missense_Mutation	SNP	G	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr7:89937126G>T	uc010lep.3	+	20	2759	c.2508G>T	c.(2506-2508)tgG>tgT	p.W836C	C7orf63_uc011khj.2_Missense_Mutation_p.W818C|C7orf63_uc011khk.2_Missense_Mutation_p.W352C	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	Homo sapiens chromosome 7 open reading frame 63 (C7orf63), transcript variant 1, mRNA.	836							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						ATAAATCATGGGAAGATTTCT	0.328000														49			3		1.23904e-05	1.2867e-05	1	1	0
TMEM132B	114795	broad.mit.edu	37	12	126138173	126138173	+	Silent	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr12:126138173C>T	uc001uhe.1	+	8	2162	c.2154C>T	c.(2152-2154)taC>taT	p.Y718Y	TMEM132B_uc001uhf.1_Silent_p.Y230Y	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	Homo sapiens transmembrane protein 132B (TMEM132B), mRNA.	718						integral to membrane		p.Y718H(1)		NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TAGACATTTACGATCCTAAGG	0.403000														193			5		0	0	1	0	0
C5	727	broad.mit.edu	37	9	123783821	123783821	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr9:123783821T>C	uc004bkv.3	-	10	1298	c.1268A>G	c.(1267-1269)aAt>aGt	p.N423S	C5_uc010mvm.1_Missense_Mutation_p.N423S|C5_uc010mvn.1_Missense_Mutation_p.N423S	NM_001735	NP_001726	P01031	CO5_HUMAN	Homo sapiens complement component 5 (C5), mRNA.	423					G-protein coupled receptor protein signaling pathway|activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	AGATGGGAGATTAAGCACAAA	0.418000														76			102		0	0	1	0	0
SLA2	84174	broad.mit.edu	37	20	35262937	35262937	+	Silent	SNP	G	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr20:35262937G>A	uc002xfv.3	-	2	570	c.147C>T	c.(145-147)gcC>gcT	p.A49A	SLA2_uc002xfu.3_Silent_p.A49A	NM_032214	NP_115590	Q9H6Q3	SLAP2_HUMAN	Homo sapiens Src-like-adaptor 2 (SLA2), transcript variant 1, mRNA.	49	SH3.				B cell mediated immunity|T cell activation|antigen receptor-mediated signaling pathway|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	SH3/SH2 adaptor activity|protein N-terminus binding			endometrium(1)|lung(2)|skin(2)	5	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GCGACAGCTCGGCCGGGCCAC	0.577000														114			31		0	0	1	0	0
ALG3	10195	broad.mit.edu	37	3	183960376	183960376	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr3:183960376C>T	uc003fne.2	-	8	1274	c.1243G>A	c.(1243-1245)Gtc>Atc	p.V415I	ALG3_uc011brc.1_Missense_Mutation_p.V380I|ALG3_uc011brd.1_Missense_Mutation_p.V359I|ALG3_uc011bre.1_Missense_Mutation_p.V367I	NM_005787	NP_005778	Q92685	ALG3_HUMAN	Homo sapiens asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae) (ALG3), transcript variant 1, mRNA.	415					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCAGGATGACGGCATGGCAT	0.592000														127			4		0	0	1	0	0
CSRNP3	80034	broad.mit.edu	37	2	166532972	166532972	+	Missense_Mutation	SNP	C	T	T	rs150240455		TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr2:166532972C>T	uc002udf.3	+	5	935	c.559C>T	c.(559-561)Cgt>Tgt	p.R187C	CSRNP3_uc002udg.3_Missense_Mutation_p.R187C	NM_001172173	NP_079245	Q8WYN3	CSRN3_HUMAN	Homo sapiens cysteine-serine-rich nuclear protein 3 (CSRNP3), transcript variant 1, mRNA.	187					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						AGCTCTGCTGCGTGCCTCTGG	0.493000														67			4		0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132919171	132919171	+	RNA	SNP	A	G	G	rs148383954	by1000genomes	TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr2:132919171A>G	uc002tti.3	-	0		c.355T>C			ANKRD30BL_uc002ttj.3_Intron					Homo sapiens ankyrin repeat domain 30B-like (ANKRD30BL), transcript variant 1, non-coding RNA.											endometrium(1)|kidney(3)	4						TGAGATCCCCATGGTGAATCA	0.582000														120			10		0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87410805	87410805	+	Missense_Mutation	SNP	A	C	C			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr8:87410805A>C	uc003ydt.3	+	6	757	c.477A>C	c.(475-477)gaA>gaC	p.E159D	WWP1_uc010mai.3_5'UTR	NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	Homo sapiens WW domain containing E3 ubiquitin protein ligase 1 (WWP1), mRNA.	159					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						GTTCAGTAGAAATACAGGAAA	0.333000														88			40		0	0	1	0	0
GLUD2	2747	broad.mit.edu	37	X	120182071	120182071	+	Missense_Mutation	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chrX:120182071C>T	uc004eto.3	+	0	610	c.533C>T	c.(532-534)cCg>cTg	p.P178L		NM_012084	NP_036216	P49448	DHE4_HUMAN	Homo sapiens glutamate dehydrogenase 2 (GLUD2), nuclear gene encoding mitochondrial protein, mRNA.	178					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|GTP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	GTTGATGTGCCGTTTGGGGGT	0.453000														101			48		0	0	1	0	0
FLJ25363	401082	broad.mit.edu	37	3	109129037	109129037	+	Silent	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr3:109129037C>T	uc003dxr.1	+	0	201	c.24C>T	c.(22-24)ggC>ggT	p.G8G		NM_001145553	NP_001139025			Homo sapiens uncharacterized LOC401082 (FLJ25363), mRNA.																		GGTGCGGCGGCGGCTGCGAAC	0.507000														75			5		0	0	1	0	0
COX7A1	1346	broad.mit.edu	37	19	36642385	36642385	+	Missense_Mutation	SNP	T	C	C			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr19:36642385T>C	uc002odm.1	-	2	628	c.166A>G	c.(166-168)Aca>Gca	p.T56A		NM_001864	NP_001855	P24310	CX7A1_HUMAN	Homo sapiens cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) (COX7A1), nuclear gene encoding mitochondrial protein, mRNA.	56					generation of precursor metabolites and energy	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity			endometrium(2)|large_intestine(1)	3	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			AGCGTCATTGTCACTCGGTAC	0.622000														124			5		0	0	1	0	0
KIAA0355	9710	broad.mit.edu	37	19	34818401	34818401	+	Nonsense_Mutation	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr19:34818401C>T	uc002nvd.4	+	3	1640	c.781C>T	c.(781-783)Caa>Taa	p.Q261*		NM_014686	NP_055501	O15063	K0355_HUMAN	Homo sapiens KIAA0355 (KIAA0355), mRNA.	261										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					CTTTTGTTCTCAAAGTGCAGC	0.403000														43			3		0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195506822	195506822	+	Missense_Mutation	SNP	C	T	T	rs74208457		TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr3:195506822C>T	uc021xjp.1	-	1	11785	c.11629G>A	c.(11629-11631)Ggc>Agc	p.G3877S	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_5'Flank|MUC4_uc021xjn.1_5'Flank|MUC4_uc021xjo.1_5'Flank|MUC4_uc021xjg.1_5'Flank|MUC4_uc021xjh.1_5'Flank|MUC4_uc021xji.1_5'Flank|MUC4_uc021xjj.1_5'Flank|MUC4_uc021xjk.1_5'Flank|MUC4_uc021xjl.1_5'Flank|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	651					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAAGGCCGGTAACAGGA	0.587000														34			3		0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13397774	13397774	+	Missense_Mutation	SNP	G	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr19:13397774G>T	uc002mwy.3	-	19	3332	c.3096C>A	c.(3094-3096)aaC>aaA	p.N1032K	CACNA1A_uc010dzc.2_Missense_Mutation_p.N558K|CACNA1A_uc010xnd.2_Missense_Mutation_p.N1035K|CACNA1A_uc021ups.1_Missense_Mutation_p.N1032K|CACNA1A_uc010xne.2_Missense_Mutation_p.N1035K|CACNA1A_uc010dze.2_Missense_Mutation_p.N1032K|CACNA1A_uc021upt.1_Missense_Mutation_p.N1033K	NM_001127222	NP_001120694	O00555	CAC1A_HUMAN	Homo sapiens calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A), transcript variant 4, mRNA.	1033					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGGAGCCCTGGTTCTCTCTGA	0.537000														66			43		1.57914e-17	1.85378e-17	1	1	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117012	117012	+	RNA	SNP	C	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chrGL000205.1:117012C>A	uc002kgk.4	+	0		c.390C>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		ACCAAAGAAGCTGTATTCCCT	0.478000														11			3		6.4e-05	6.4e-05	1	1	0
CLDN3	1365	broad.mit.edu	37	7	73184305	73184305	+	Silent	SNP	C	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr7:73184305C>T	uc003tzg.4	-	0	296	c.75G>A	c.(73-75)gcG>gcA	p.A25A		NM_001306	NP_001297	O15551	CLD3_HUMAN	Homo sapiens claudin 3 (CLDN3), mRNA.	25					response to hypoxia	integral to plasma membrane|tight junction	structural molecule activity|transmembrane receptor activity			kidney(1)|lung(1)	2		Lung NSC(55;0.159)				ACATGGGCAACGCGCAGCACA	0.672000														60			3		0	0	1	0	0
RNASEH2A	10535	broad.mit.edu	37	19	12917591	12917591	+	Missense_Mutation	SNP	A	T	T			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr19:12917591A>T	uc002mvg.1	+	0	164	c.104A>T	c.(103-105)gAg>gTg	p.E35V		NM_006397	NP_006388	O75792	RNH2A_HUMAN	Homo sapiens ribonuclease H2, subunit A (RNASEH2A), mRNA.	35					DNA replication|RNA catabolic process	nucleus|ribonuclease H2 complex	RNA binding|metal ion binding|ribonuclease H activity			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	14						GGCGTCGATGAGGCGGGCAGG	0.692000														62			24		0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3917706	3917706	+	Missense_Mutation	SNP	T	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr17:3917706T>A	uc002fxe.3	-	49	8313	c.8249A>T	c.(8248-8250)gAc>gTc	p.D2750V	ZZEF1_uc002fxg.1_Missense_Mutation_p.D71V	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	Homo sapiens zinc finger, ZZ-type with EF-hand domain 1 (ZZEF1), mRNA.	2750							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TTGCTGGAAGTCACTGCTGCT	0.473000														60			55		0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180910361	180910362	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr1:180910361_180910362insC	uc001gok.2	+	6	3166_3167	c.3099_3100insC	c.(3097-3102)cagcccfs	p.Q1033fs	KIAA1614_uc001gol.1_Frame_Shift_Ins_p.Q654fs|KIAA1614_uc001gom.1_Frame_Shift_Ins_p.Q124fs	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	Homo sapiens KIAA1614 (KIAA1614), mRNA.	1033	Ser-rich.									NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						AGCAGTTGCAGCCCGCCCCGCC	0.658													---	220	---	---	9	---					
FHDC1	85462	broad.mit.edu	37	4	153896828	153896829	+	Frame_Shift_Ins	INS	-	G	G	rs144649820		TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr4:153896828_153896829insG	uc003inf.2	+	10	2460_2461	c.2385_2386insG	c.(2383-2388)ggcgggfs	p.G795fs		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	Homo sapiens FH2 domain containing 1 (FHDC1), mRNA.	795					actin cytoskeleton organization		actin binding	p.R794T(1)	ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					GACCCAGAGGCGGGGACCCGGA	0.614													---	173	---	---	7	---					
HCN1	348980	broad.mit.edu	37	5	45262024	45262025	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr5:45262024_45262025insA	uc003jok.3	-	7	2696_2697	c.2671_2672insT	c.(2671-2673)tgafs	p.*891fs		NM_021072	NP_066550	O60741	HCN1_HUMAN	Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (HCN1), mRNA.	0						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CAGCAGGGATCATAAATTTGAA	0.431													---	32	---	---	34	---					
FOXD4	2298	broad.mit.edu	37	9	117662	117663	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr9:117662_117663insG	uc003zfz.3	-	0	755_756	c.457_458insC	c.(457-459)cgcfs	p.R153fs		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	Homo sapiens forkhead box D4 (FOXD4), mRNA.	153					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GAGGTTGTGGCGGATGCTGTTC	0.658													---	278	---	---	9	---					
TRIM64	120146	broad.mit.edu	37	11	89704425	89704426	+	Splice_Site	INS	-	A	A			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr11:89704425_89704426insA	uc010rty.2	+	4	758	c.758_splice	c.e4+2	p.R253_splice		NM_001136486	NP_001129958	A6NGJ6	TRI64_HUMAN	Homo sapiens tripartite motif containing 64 (TRIM64), mRNA.	253						intracellular	zinc ion binding										ATCAGCAAGGTGATTTTACACT	0.327													---	4	---	---	2	---					
ARF3	377	broad.mit.edu	37	12	49332755	49332756	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr12:49332755_49332756insC	uc001rsr.2	-	4	773_774	c.520_521insG	c.(520-522)gccfs	p.A174fs	ARF3_uc010smc.1_Frame_Shift_Ins_p.A137fs	NM_001659	NP_001650	P61204	ARF3_HUMAN	Homo sapiens ADP-ribosylation factor 3 (ARF3), mRNA.	174					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity			endometrium(1)|lung(2)|skin(1)	4						GAGCTGATTGGCCAGCCAGTCC	0.584													---	213	---	---	7	---					
GOLGA6L6	727832	broad.mit.edu	37	15	20740108	20740108	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr15:20740108delT	uc001ytk.2	-	7	1733	c.1642delA	c.(1642-1644)aggfs	p.R548fs	DQ594309_uc010tzb.1_5'Flank	NM_001145004	NP_001138476	A8MZA4	GG6L6_HUMAN	Homo sapiens golgin A6 family-like 6 (GOLGA6L6), mRNA.	548	Gln-rich.|Glu-rich.									NS(3)|endometrium(4)|kidney(1)|skin(3)	11						tcttcctccctccacatctcc	0.557													---	409	---	---	9	---					
ARHGAP11A	9824	broad.mit.edu	37	15	32908429	32908430	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr15:32908429_32908430insG	uc001zgy.1	+	0	739_740	c.17_18insG	c.(16-18)ctgfs	p.L6fs	ARHGAP11A_uc010ubw.1_Intron|ARHGAP11A_uc001zgw.3_Frame_Shift_Ins_p.L6fs|ARHGAP11A_uc010ubx.1_Intron	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Homo sapiens Rho GTPase activating protein 11A (ARHGAP11A), transcript variant 1, mRNA.	6					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		GATCAGAGGCTGGTGAGGTTGG	0.554													---	299	---	---	8	---					
CKMT1B	1159	broad.mit.edu	37	15	43890418	43890419	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr15:43890418_43890419insG	uc001zsc.3	+	7	1296_1297	c.904_905insG	c.(904-906)tggfs	p.W302fs	CKMT1B_uc010uds.2_Frame_Shift_Ins_p.W333fs|CKMT1B_uc010udv.1_3'UTR|CKMT1B_uc010bdj.3_Non-coding_Transcript|CKMT1B_uc010udy.1_Non-coding_Transcript	NM_020990	NP_066270	P12532	KCRU_HUMAN	Homo sapiens creatine kinase, mitochondrial 1B (CKMT1B), nuclear gene encoding mitochondrial protein, mRNA.	302	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			large_intestine(1)|lung(3)|skin(1)	5		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	AGAACGTGGCTGGGAGTTCATG	0.490													---	705	---	---	11	---					
HERC1	8925	broad.mit.edu	37	15	64017642	64017643	+	Frame_Shift_Ins	INS	-	A	A	rs5813236		TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr15:64017642_64017643insA	uc002amp.3	-	17	3564_3565	c.3416_3417insT	c.(3415-3417)gtgfs	p.V1139fs	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	Homo sapiens hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 (HERC1), mRNA.	1139					protein modification process|transport	Golgi apparatus|cytosol|membrane	ARF guanyl-nucleotide exchange factor activity|acid-amino acid ligase activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TTTCTAGATCCACAAGCCATAC	0.485													---	178	---	---	7	---					
ATMIN	23300	broad.mit.edu	37	16	81078086	81078087	+	Frame_Shift_Ins	INS	-	G	G	rs140077063		TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr16:81078086_81078087insG	uc002ffz.1	+	3	2001_2002	c.1983_1984insG	c.(1981-1986)accgagfs	p.T661fs	ATMIN_uc002fga.2_Frame_Shift_Ins_p.T503fs|ATMIN_uc010vnn.1_Frame_Shift_Ins_p.T432fs|ATMIN_uc002fgb.1_Frame_Shift_Ins_p.T503fs	NM_015251	NP_056066	O43313	ATMIN_HUMAN	Homo sapiens ATM interactor (ATMIN), mRNA.	661					response to DNA damage stimulus	nucleus	zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	20						CCATGACCACCGAGCCAGTCTT	0.470													---	205	---	---	7	---					
UCKL1	54963	broad.mit.edu	37	20	62576011	62576011	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chr20:62576011delT	uc010gkn.3	-	5	806	c.731delA	c.(730-732)gagfs	p.E244fs	UCKL1_uc011abm.2_Frame_Shift_Del_p.E229fs|UCKL1_uc011abn.2_Non-coding_Transcript|UCKL1_uc011abo.2_Non-coding_Transcript|MIR647_uc021wgn.1_5'Flank	NM_017859	NP_060329	Q9NWZ5	UCKL1_HUMAN	Homo sapiens uridine-cytidine kinase 1-like 1 (UCKL1), transcript variant 1, mRNA.	244					interspecies interaction between organisms	endoplasmic reticulum|nucleus	ATP binding|phosphotransferase activity, alcohol group as acceptor|protein binding|uridine kinase activity			endometrium(3)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	8	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CCGGCCGCGCTCACTGATGTC	0.602													---	259	---	---	7	---					
MBTPS2	51360	broad.mit.edu	37	X	21896681	21896681	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chrX:21896681delA	uc004dae.3	+	8	1329	c.1132delA	c.(1132-1134)aaafs	p.K378fs	MBTPS2_uc010nfr.3_5'UTR	NM_015884	NP_056968	O43462	MBTP2_HUMAN	Homo sapiens membrane-bound transcription factor peptidase, site 2 (MBTPS2), mRNA.	378	Cys-rich.				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity	p.S380fs*28(1)		breast(2)|endometrium(3)|large_intestine(3)|lung(13)|ovary(1)|skin(2)	24						TAAAGACTGTAAAAAAAGCTC	0.328													---	422	---	---	7	---					
SYTL5	94122	broad.mit.edu	37	X	37932872	37932873	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chrX:37932872_37932873insC	uc004ddx.3	+	3	831_832	c.475_476insC	c.(475-477)accfs	p.T159fs	SYTL5_uc004ddu.3_Frame_Shift_Ins_p.T159fs|SYTL5_uc004ddv.3_Frame_Shift_Ins_p.T159fs	NM_001163334	NP_001156806	Q8TDW5	SYTL5_HUMAN	Homo sapiens synaptotagmin-like 5 (SYTL5), transcript variant 3, mRNA.	159					intracellular protein transport	membrane	Rab GTPase binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	44						CCAAGAGCAAACCCGCCAGGAT	0.446													---	430	---	---	9	---					
PRRG3	79057	broad.mit.edu	37	X	150869347	150869348	+	Frame_Shift_Del	DEL	CT	-	-	rs149812906	byFrequency	TCGA-KN-8433-01A-11D-2310-10	TCGA-KN-8433-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b6e97d6b-3b11-4cee-a4a9-2b59d6e88a3d	f16bdd65-b3fd-46c9-b27f-ad59ee5a9916	g.chrX:150869347_150869348delCT	uc022cgt.1	+	3	587_588	c.538_539delCT	c.(538-540)ctcfs	p.L180fs	PRRG3_uc004few.2_Frame_Shift_Del_p.L180fs	NM_024082	NP_076987	Q9BZD7	TMG3_HUMAN	Homo sapiens proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (PRRG3), transcript variant 1, mRNA.	180						extracellular region|integral to membrane	calcium ion binding	p.E179Q(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(3)|prostate(2)|skin(3)	24	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCCTGAGCTCTCTCTCTCC	0.663													---	357	---	---	7	---					
