Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM83C	128876	broad.mit.edu	37	20	33874426	33874426	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr20:33874426C>T	uc021wck.1	-	3	2274	c.2156G>A	c.(2155-2157)cGg>cAg	p.R719Q	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Missense_Mutation_p.R374Q	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	Homo sapiens family with sequence similarity 83, member C (FAM83C), mRNA.	719										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CAGGGTCAGCCGTTTCTCATC	0.557000														86			88		0	0	1	0	0
PTPN5	84867	broad.mit.edu	37	11	18755149	18755149	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:18755149T>C	uc001mpd.3	-	9	1465	c.1034A>G	c.(1033-1035)gAc>gGc	p.D345G	PTPN5_uc001mpb.3_Missense_Mutation_p.D313G|PTPN5_uc001mpc.3_Missense_Mutation_p.D345G|PTPN5_uc010rdj.2_Missense_Mutation_p.D289G|PTPN5_uc001mpf.3_Missense_Mutation_p.D321G|PTPN5_uc001mpe.3_Missense_Mutation_p.D313G|PTPN5_uc010rdk.2_Missense_Mutation_p.D290G	NM_006906	NP_116170	P54829	PTN5_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) (PTPN5), transcript variant 1, mRNA.	345	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						GTCGTCAGGGTCTGGTGAGGT	0.592000														295			7		0	0	1	0	0
APH1A	51107	broad.mit.edu	37	1	150240152	150240152	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:150240152C>T	uc001ety.2	-	2	721	c.322G>A	c.(322-324)Gga>Aga	p.G108R	APH1A_uc001etz.2_Missense_Mutation_p.G108R|APH1A_uc010pbx.2_Intron|APH1A_uc010pby.2_Missense_Mutation_p.G51R|APH1A_uc010pbz.2_5'UTR	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	Homo sapiens anterior pharynx defective 1 homolog A (C. elegans) (APH1A), transcript variant 1, mRNA.	108					Notch receptor processing|Notch signaling pathway|amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|positive regulation of catalytic activity|protein processing	Golgi cisterna membrane|endoplasmic reticulum membrane|integral to plasma membrane	protein binding			breast(1)|lung(4)|ovary(1)|skin(1)|urinary_tract(2)	9	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTGATCTTCCGTCCTCACTC	0.592000														112			4		0	0	1	0	0
PRKAG3	53632	broad.mit.edu	37	2	219695480	219695480	+	Missense_Mutation	SNP	C	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr2:219695480C>A	uc002vjb.1	-	2	237	c.218G>T	c.(217-219)gGt>gTt	p.G73V	PRKAG3_uc010zkn.1_Non-coding_Transcript|PRKAG3_uc010fvy.1_Missense_Mutation_p.G73V|PRKAG3_uc010zko.1_Splice_Site_p.G73_splice	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	Homo sapiens protein kinase, AMP-activated, gamma 3 non-catalytic subunit (PRKAG3), mRNA.	73					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			large_intestine(7)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TTCCCCCTGACCTGGTGGCTC	0.617000														59			5		0.000602214	0.000602214	1	1	0
SLC15A2	6565	broad.mit.edu	37	3	121659851	121659851	+	Silent	SNP	C	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:121659851C>A	uc003eep.2	+	21	2340	c.2187C>A	c.(2185-2187)ctC>ctA	p.L729L	SLC15A2_uc011bjn.1_Silent_p.L698L	NM_021082	NP_066568	Q16348	S15A2_HUMAN	Homo sapiens solute carrier family 15 (H+/peptide transporter), member 2 (SLC15A2), transcript variant 1, mRNA.	729					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	AGACAAAACTCTGATGACTCC	0.443000														154			62		9.12251e-31	1.02628e-30	1	1	0
KLHDC2	23588	broad.mit.edu	37	14	50244621	50244621	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr14:50244621G>A	uc001wwx.3	+	3	816	c.416G>A	c.(415-417)gGa>gAa	p.G139E	NEMF_uc010anj.1_Intron	NM_014315	NP_055130	Q9Y2U9	KLDC2_HUMAN	Homo sapiens kelch domain containing 2 (KLHDC2), mRNA.	139						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(31;0.000959)|Breast(41;0.0117)					GATTGCCAAGGAATTCCTCCA	0.388000														82			41		0	0	1	0	0
GLRA1	2741	broad.mit.edu	37	5	151202298	151202298	+	Missense_Mutation	SNP	A	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr5:151202298A>C	uc003lut.3	-	8	1597	c.1310T>G	c.(1309-1311)aTt>aGt	p.I437S	GLRA1_uc003lur.3_Missense_Mutation_p.I429S|GLRA1_uc003lus.3_Missense_Mutation_p.I346S	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	Homo sapiens glycine receptor, alpha 1 (GLRA1), transcript variant 1, mRNA.	437					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CATGTTGAAAATGAGGAAGGC	0.512000														144			39		0	0	1	0	0
IZUMO2	126123	broad.mit.edu	37	19	50662801	50662801	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:50662801G>A	uc002prp.1	-	2	431	c.344C>T	c.(343-345)gCg>gTg	p.A115V		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	Homo sapiens IZUMO family member 2 (IZUMO2), mRNA.	115						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						GATCACATTCGCCCTGAGGGT	0.493000														96			68		0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56087702	56087702	+	Silent	SNP	A	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr20:56087702A>G	uc010giw.1	-	7	1548	c.1437T>C	c.(1435-1437)acT>acC	p.T479T	CTCFL_uc010gix.1_Silent_p.T479T|CTCFL_uc002xym.2_Silent_p.T479T|CTCFL_uc010gjb.1_Silent_p.T479T|CTCFL_uc010gja.1_Silent_p.T429T|CTCFL_uc010gjc.1_Silent_p.T479T|CTCFL_uc010gjd.1_Silent_p.T479T|CTCFL_uc010gje.3_Silent_p.T479T|CTCFL_uc010gjg.3_Silent_p.T211T|CTCFL_uc010gjf.3_Silent_p.T274T|CTCFL_uc010gjh.2_Intron|CTCFL_uc010gji.2_Silent_p.T274T|CTCFL_uc010gjj.2_Silent_p.T479T	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	Homo sapiens CCCTC-binding factor (zinc finger protein)-like (CTCFL), mRNA.	479					DNA methylation involved in gamete generation|cell cycle|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CATTCTTATGAGTTTTCTGGT	0.453000														202			53		0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71375627	71375627	+	Silent	SNP	C	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr17:71375627C>A	uc010dfm.3	-	34	4824	c.4824G>T	c.(4822-4824)ggG>ggT	p.G1608G	SDK2_uc002jjt.4_Silent_p.G748G|SDK2_uc010dfn.2_Silent_p.G1287G	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	Homo sapiens sidekick cell adhesion molecule 2 (SDK2), mRNA.	1608	Fibronectin type-III 10.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GGCTGGAGGGCCCCTCACCCA	0.662000														21			49		8.44121e-28	9.30256e-28	1	1	0
HTR3E	285242	broad.mit.edu	37	3	183824286	183824286	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:183824286G>T	uc010hxr.3	+	6	1448	c.1254G>T	c.(1252-1254)atG>atT	p.M418I	HTR3E_uc010hxq.3_Missense_Mutation_p.M392I|HTR3E_uc003fml.4_Missense_Mutation_p.M377I|HTR3E_uc003fmm.3_Missense_Mutation_p.M407I|HTR3E_uc003fmn.3_Missense_Mutation_p.M392I	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member E (HTR3E), mRNA.	392						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CAGGGCAGATGCCGGGCCCTG	0.612000														245			6		8.12818e-05	8.28155e-05	1	1	0
ATAD3C	219293	broad.mit.edu	37	1	1389871	1389871	+	Silent	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:1389871C>T	uc001aft.2	+	3	1364	c.369C>T	c.(367-369)caC>caT	p.H123H		NM_001039211	NP_001034300	Q5T2N8	ATD3C_HUMAN	Homo sapiens ATPase family, AAA domain containing 3C (ATAD3C), mRNA.	123							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		CGCTGCGGCACCCCATCCAGG	0.667000														138			92		0	0	1	0	0
UHRF1	29128	broad.mit.edu	37	19	4960756	4960756	+	Missense_Mutation	SNP	A	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:4960756A>C	uc002mbp.3	+	16	2653	c.2360A>C	c.(2359-2361)aAc>aCc	p.N787T	UHRF1_uc002mbo.3_Missense_Mutation_p.N774T|UHRF1_uc010xik.2_Non-coding_Transcript|UHRF1_uc010duf.3_Non-coding_Transcript	NM_013282	NP_037414	Q96T88	UHRF1_HUMAN	Homo sapiens ubiquitin-like with PHD and ring finger domains 1 (UHRF1), transcript variant 2, mRNA.	775					DNA repair|cell cycle|cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.N787T(2)		breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		ATGCAGGTGAACCAGCCTCTG	0.597000														59			7		0	0	1	0	0
RAB12	201475	broad.mit.edu	37	18	8609872	8609872	+	Silent	SNP	C	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr18:8609872C>A	uc002knp.3	+	0	430	c.147C>A	c.(145-147)ggC>ggA	p.G49G	RAB12_uc002kno.1_Silent_p.G145G	NM_001025300	NP_001020471	Q6IQ22	RAB12_HUMAN	Homo sapiens RAB12, member RAS oncogene family (RAB12), mRNA.	49					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding	p.G49G(2)		breast(1)|lung(4)|prostate(1)|urinary_tract(1)	7						TCATTATCGGCTCCCGCGGCG	0.711000														44			7		1.5842e-08	1.64513e-08	1	1	0
LRPPRC	10128	broad.mit.edu	37	2	44139675	44139675	+	Missense_Mutation	SNP	A	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr2:44139675A>T	uc002rtr.2	-	29	3229	c.3171T>A	c.(3169-3171)aaT>aaA	p.N1057K	LRPPRC_uc010yob.1_Missense_Mutation_p.N957K	NM_133259	NP_573566	P42704	LPPRC_HUMAN	Homo sapiens leucine-rich PPR-motif containing (LRPPRC), mRNA.	1057					mRNA transport|mitochondrion transport along microtubule|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	RNA binding|beta-tubulin binding|microtubule binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCTCTTTTGCATTCAGGAAAA	0.323000														76			187		0	0	1	0	0
ACSM2A	123876	broad.mit.edu	37	16	20497990	20497990	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr16:20497990G>A	uc010bwe.3	+	14	1963	c.1724G>A	c.(1723-1725)cGt>cAt	p.R575H	ACSM2A_uc002dhf.4_Missense_Mutation_p.R575H|ACSM2A_uc002dhg.4_Missense_Mutation_p.R575H|ACSM2A_uc010vay.2_Missense_Mutation_p.R496H|ACSM2A_uc002dhh.4_Missense_Mutation_p.R205H|AX747287_uc002dhi.1_5'Flank	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	Homo sapiens acyl-CoA synthetase medium-chain family member 2A (ACSM2A), nuclear gene encoding mitochondrial protein, mRNA.	575					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GGAAAAGCCCGTGCGCAGTGA	0.463000														88			48		0	0	1	0	0
AOX1	316	broad.mit.edu	37	2	201462175	201462175	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr2:201462175G>A	uc002uvx.3	+	3	357	c.256G>A	c.(256-258)Gtc>Atc	p.V86I		NM_001159	NP_001150	Q06278	ADO_HUMAN	Homo sapiens aldehyde oxidase 1 (AOX1), mRNA.	86	2Fe-2S ferredoxin-type.				inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|NAD binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TGGTGCTGCCGTCACCACAGT	0.458000														96			7		0	0	1	0	0
WWTR1	25937	broad.mit.edu	37	3	149245708	149245708	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:149245708G>A	uc003exf.3	-	4	1160	c.820C>T	c.(820-822)Cca>Tca	p.P274S	WWTR1_uc003exe.3_Missense_Mutation_p.P274S|WWTR1_uc021xfm.1_Missense_Mutation_p.P274S|WWTR1_uc003exh.3_Missense_Mutation_p.P274S	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	Homo sapiens WW domain containing transcription regulator 1 (WWTR1), transcript variant 1, mRNA.	274					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCCTGAACTGGGGCAAGAGTC	0.498000			T	CAMTA1	epitheliod hemangioendothelioma									39			88		0	0	1	0	0
DFFA	1676	broad.mit.edu	37	1	10527276	10527276	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:10527276T>C	uc001arj.3	-	2	510	c.412A>G	c.(412-414)Atc>Gtc	p.I138V	DFFA_uc001ark.3_Missense_Mutation_p.I138V	NM_004401	NP_004392	O00273	DFFA_HUMAN	Homo sapiens DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1, mRNA.	138					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding			large_intestine(3)|lung(2)	5	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		AGGAGGATGATGCTGGACAGA	0.532000														53			99		0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33405554	33405554	+	Missense_Mutation	SNP	A	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr6:33405554A>C	uc011dri.2	+	7	1067	c.872A>C	c.(871-873)tAt>tCt	p.Y291S	SYNGAP1_uc003oeo.1_Missense_Mutation_p.Y276S|SYNGAP1_uc010juy.3_Missense_Mutation_p.Y276S|SYNGAP1_uc010juz.3_Missense_Mutation_p.Y3S	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	Homo sapiens synaptic Ras GTPase activating protein 1 (SYNGAP1), mRNA.	291	C2.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding	p.T290T(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						GACATGCTGTATGCACGCACC	0.617000														29			39		0	0	1	0	0
HTR3E	285242	broad.mit.edu	37	3	183824287	183824287	+	Missense_Mutation	SNP	C	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:183824287C>G	uc010hxr.3	+	6	1449	c.1255C>G	c.(1255-1257)Ccg>Gcg	p.P419A	HTR3E_uc010hxq.3_Missense_Mutation_p.P393A|HTR3E_uc003fml.4_Missense_Mutation_p.P378A|HTR3E_uc003fmm.3_Missense_Mutation_p.P408A|HTR3E_uc003fmn.3_Missense_Mutation_p.P393A	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	Homo sapiens 5-hydroxytryptamine (serotonin) receptor 3, family member E (HTR3E), mRNA.	393						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGGGCAGATGCCGGGCCCTGC	0.612000														241			5		0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4029168	4029168	+	Silent	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr16:4029168G>A	uc002cvx.3	-	7	3167	c.2628C>T	c.(2626-2628)ccC>ccT	p.P876P		NM_001116	NP_001107	O60503	ADCY9_HUMAN	Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.	876					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	ATP binding|adenylate cyclase activity|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CGGCCAGTGCGGGAAGCGACA	0.582000														46			26		0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2512477	2512477	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr16:2512477G>A	uc002cqh.3	+	6	843	c.812G>A	c.(811-813)cGg>cAg	p.R271Q	C16orf59_uc002cqg.2_Missense_Mutation_p.R104Q|C16orf59_uc002cqi.3_Missense_Mutation_p.R104Q|C16orf59_uc010uwb.2_Missense_Mutation_p.R104Q	NM_025108	NP_079384	Q7L2K0	CP059_HUMAN	Homo sapiens chromosome 16 open reading frame 59 (C16orf59), mRNA.	271										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				GGGCGCCTGCGGAAGGCCTGC	0.662000														63			5		0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113459692	113459692	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr9:113459692G>A	uc022blv.1	+	4	708	c.574G>A	c.(574-576)Gca>Aca	p.A192T	MUSK_uc022blt.1_Missense_Mutation_p.A192T|MUSK_uc004bez.2_Missense_Mutation_p.A192T|MUSK_uc022blu.1_Missense_Mutation_p.A192T	NM_005592	NP_005583	O15146	MUSK_HUMAN	Homo sapiens muscle, skeletal, receptor tyrosine kinase (MUSK), transcript variant 1, mRNA.	192	Ig-like 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.V191A(1)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						TCGATGTGTGGCAAAAAACAG	0.483000														137			4		0	0	1	0	0
OR1S1	219959	broad.mit.edu	37	11	57982580	57982580	+	Missense_Mutation	SNP	G	A	A	rs147498041		TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:57982580G>A	uc010rkc.2	+	0	364	c.364G>A	c.(364-366)Gtc>Atc	p.V122I		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	Homo sapiens olfactory receptor, family 1, subfamily S, member 1 (OR1S1), mRNA.	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				TGTGTTTGTCGTCATTGACAA	0.453000														319			5		0	0	1	0	0
LMTK2	22853	broad.mit.edu	37	7	97820153	97820153	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr7:97820153C>T	uc003upd.2	+	9	1405	c.1112C>T	c.(1111-1113)cCg>cTg	p.P371L		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	Homo sapiens lemur tyrosine kinase 2 (LMTK2), mRNA.	371	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	Golgi apparatus|early endosome|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					ACAAAACTCCCGAAGCCCCAG	0.488000														117			36		0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53189775	53189775	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr12:53189775C>T	uc001say.3	-	0	118	c.52G>A	c.(52-54)Ggc>Agc	p.G18S		NM_057088	NP_476429	P12035	K2C3_HUMAN	Homo sapiens keratin 3 (KRT3), mRNA.	18	Gly-rich.|Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						GCAGAGCGGCCGGAGAAACCC	0.622000														38			14		0	0	1	0	0
PPP1CC	5501	broad.mit.edu	37	12	111160464	111160464	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr12:111160464C>T	uc001tru.3	-	4	831	c.560G>A	c.(559-561)cGg>cAg	p.R187Q	PPP1CC_uc021rdx.1_Missense_Mutation_p.R187Q	NM_002710	NP_002701	P36873	PP1G_HUMAN	Homo sapiens protein phosphatase 1, catalytic subunit, gamma isozyme (PPP1CC), transcript variant 1, mRNA.	187					cell division|glycogen metabolic process|mitotic prometaphase|triglyceride catabolic process	MLL5-L complex|PTW/PP1 phosphatase complex|cleavage furrow|condensed chromosome kinetochore|cytosol|midbody|nuclear speck|nucleolus	metal ion binding|protein binding|protein kinase binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|large_intestine(2)|lung(3)	6						CATAATTCGCCGAATCTGCTC	0.393000														42			15		0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195505819	195505819	+	Missense_Mutation	SNP	A	T	T	rs425588		TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:195505819A>T	uc021xjp.1	-	1	12788	c.12632T>A	c.(12631-12633)gTc>gAc	p.V4211D	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_Intron|MUC4_uc021xjn.1_Intron|MUC4_uc021xjo.1_Intron|MUC4_uc021xjg.1_Intron|MUC4_uc021xjh.1_Intron|MUC4_uc021xji.1_Intron|MUC4_uc021xjj.1_Intron|MUC4_uc021xjk.1_Intron|MUC4_uc021xjl.1_Intron|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	970					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.V4211D(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGTGTCGGTGACAGGAAGAGG	0.597000														90			8		0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172037991	172037991	+	Silent	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:172037991G>A	uc001gie.3	+	10	1544	c.1368G>A	c.(1366-1368)acG>acA	p.T456T	DNM3_uc001gid.4_Silent_p.T456T|DNM3_uc009wwb.2_Silent_p.T456T|DNM3_uc001gif.3_Silent_p.T456T	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	Homo sapiens dynamin 3 (DNM3), transcript variant 1, mRNA.	456					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GCGAGGAAACGGAAAGGATTG	0.468000														38			22		0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68624721	68624721	+	Silent	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr15:68624721G>A	uc010bib.3	-	12	1608	c.1521C>T	c.(1519-1521)aaC>aaT	p.N507N	ITGA11_uc002ari.3_Silent_p.N507N	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	Homo sapiens integrin, alpha 11 (ITGA11), mRNA.	507					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	CACGGCCCTCGTTGAAGTACA	0.597000														26			9		0	0	1	0	0
OR56A1	120796	broad.mit.edu	37	11	6048328	6048328	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:6048328T>C	uc010qzw.2	-	0	644	c.607A>G	c.(607-609)Aga>Gga	p.R203G		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	Homo sapiens olfactory receptor, family 56, subfamily A, member 1 (OR56A1), mRNA.	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(22)|ovary(2)	33		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGTAGATTCTGTTAAGGGTG	0.448000														27			48		0	0	1	0	0
COL6A5	256076	broad.mit.edu	37	3	130098678	130098678	+	Missense_Mutation	SNP	G	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:130098678G>C	uc010htj.1	+	3	1579	c.1085G>C	c.(1084-1086)cGa>cCa	p.R362P	COL6A5_uc010hti.1_Non-coding_Transcript	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	Homo sapiens collagen, type VI, alpha 5 (COL6A5), mRNA.	362	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						CTGAACCTTCGACTGGAGGAT	0.483000														124			57		0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69795705	69795705	+	Silent	SNP	T	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr4:69795705T>G	uc003hef.2	-	5	1441	c.1410A>C	c.(1408-1410)ggA>ggC	p.G470G	UGT2A3_uc010ihp.1_Non-coding_Transcript	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	Homo sapiens UDP glucuronosyltransferase 2 family, polypeptide A3 (UGT2A3), mRNA.	470						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GGTGCTTGGCTCCTTTGTGGC	0.488000														177			5		0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53586462	53586462	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chrX:53586462G>T	uc004dsp.3	-	56	8170	c.7768C>A	c.(7768-7770)Ctt>Att	p.L2590I	HUWE1_uc004dsn.3_Missense_Mutation_p.L1414I|MIRLET7F2_uc004dss.2_5'Flank	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	Homo sapiens HECT, UBA and WWE domain containing 1 (HUWE1), mRNA.	2590					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CTCAGCTGAAGGATGTCAGCA	0.572000														24			56		3.36121e-32	3.86181e-32	1	1	0
LRRC25	126364	broad.mit.edu	37	19	18507174	18507174	+	Silent	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:18507174C>T	uc002niw.3	-	0	1242	c.600G>A	c.(598-600)gaG>gaA	p.E200E	LRRC25_uc002nix.3_Silent_p.E200E	NM_145256	NP_660299	Q8N386	LRC25_HUMAN	Homo sapiens leucine rich repeat containing 25 (LRRC25), mRNA.	200						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|skin(1)	8						GTTTGTTCAGCTCCCGGCTTC	0.677000														54			28		0	0	1	0	0
FGL2	10875	broad.mit.edu	37	7	76828642	76828642	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr7:76828642G>A	uc003ugb.3	-	0	509	c.469C>T	c.(469-471)Cgc>Tgc	p.R157C	CCDC146_uc003ufz.1_Intron|CCDC146_uc003uga.3_Intron	NM_006682	NP_006673	Q14314	FGL2_HUMAN	Homo sapiens fibrinogen-like 2 (FGL2), mRNA.	157					signal transduction	fibrinogen complex	receptor binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	13						TTCTCCAGGCGACCATGAAGT	0.383000														216			6		0	0	1	0	0
ABHD14A	25864	broad.mit.edu	37	3	52014930	52014930	+	Missense_Mutation	SNP	A	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:52014930A>C	uc003dco.3	+	4	822	c.712A>C	c.(712-714)Aac>Cac	p.N238H	ABHD14B_uc003dcn.3_Intron|ACY1_uc011bea.2_Intron|ACY1_uc011beb.2_5'Flank|ACY1_uc003dcp.3_5'Flank|ACY1_uc003dcq.3_5'Flank|ACY1_uc021wzb.1_5'Flank|ACY1_uc021wzc.1_5'Flank|ACY1_uc021wzd.1_5'Flank	NM_015407	NP_056222	Q9BUJ0	ABHEA_HUMAN	Homo sapiens abhydrolase domain containing 14A (ABHD14A), mRNA.	238						cytoplasm|integral to membrane	hydrolase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCACCTGCCCAACCACTCTGT	0.592000														86			7		0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577609	7577609	+	Splice_Site	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr17:7577609C>T	uc002gim.2	-	7	867	c.673_splice	c.e7-1	p.V225_splice	TP53_uc002gig.1_Splice_Site_p.V225_splice|TP53_uc002gih.3_Splice_Site_p.V225_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Splice_Site_p.V93_splice|TP53_uc010cnf.1_Splice_Site_p.V93_splice|TP53_uc002gii.1_Splice_Site_p.V93_splice|TP53_uc010cni.1_Splice_Site_p.V225_splice|TP53_uc010cnh.1_Splice_Site_p.V225_splice|TP53_uc002gij.2_Splice_Site_p.V225_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|DL476358_uc021tph.1_5'Flank	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	225	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation).|V -> D (in a sporadic cancer; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> G (in a sporadic cancer; somatic mutation).|V -> I (in sporadic cancers; somatic mutation).|V -> L (in a sporadic cancer; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(33)|p.0?(8)|p.V225fs*24(1)|p.E224_V225insXX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGAGCCAACCTAGGAGATAA	0.527000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)				30			80		0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49001439	49001439	+	Nonsense_Mutation	SNP	C	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:49001439C>A	uc002pjk.3	-	11	2974	c.2974G>T	c.(2974-2976)Gag>Tag	p.E992*		NM_001080434	NP_001073903			Homo sapiens lemur tyrosine kinase 3 (LMTK3), mRNA.											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGTGTCAGCTCCCCATTCTCC	0.652000														38			28		5.91797e-21	6.3914e-21	1	1	0
COL19A1	1310	broad.mit.edu	37	6	70873233	70873233	+	Splice_Site	SNP	A	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr6:70873233A>T	uc003pfc.1	+	36	2464	c.2347_splice	c.e36-2	p.G783_splice	COL19A1_uc010kam.2_Splice_Site_p.G679_splice	NM_001858	NP_001849	Q14993	COJA1_HUMAN	Homo sapiens collagen, type XIX, alpha 1 (COL19A1), mRNA.	783	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TGTGTTTTACAGGGCTTAATG	0.403000														121			5		0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50042932	50042932	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr12:50042932T>C	uc001ruv.1	-	20	2629	c.2395A>G	c.(2395-2397)Acc>Gcc	p.T799A	FMNL3_uc001ruw.1_Missense_Mutation_p.T748A|FMNL3_uc001rut.1_Missense_Mutation_p.T365A|FMNL3_uc001ruu.1_Missense_Mutation_p.T649A	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	Homo sapiens formin-like 3 (FMNL3), transcript variant 1, mRNA.	799	FH2.				actin cytoskeleton organization		Rho GTPase binding|actin binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						GTGGACTTGGTATCCAGCAGC	0.572000														83			3		0	0	1	0	0
CYLD	1540	broad.mit.edu	37	16	50825539	50825539	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr16:50825539G>A	uc021tib.1	+	12	2302	c.2179G>A	c.(2179-2181)Gtt>Att	p.V727I	CYLD_uc010cbs.1_Missense_Mutation_p.V724I|CYLD_uc002egp.1_Missense_Mutation_p.V724I|CYLD_uc002egq.1_Missense_Mutation_p.V724I|CYLD_uc002egr.1_Missense_Mutation_p.V724I|CYLD_uc021tic.1_Non-coding_Transcript	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	Homo sapiens cylindromatosis (turban tumor syndrome) (CYLD), transcript variant 1, mRNA.	727					Wnt receptor signaling pathway|cell cycle|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(9)|lung(17)|pancreas(1)|skin(22)|upper_aerodigestive_tract(1)	62		all_cancers(37;0.0156)				GAAAGTTGGCGTTCCCACAAT	0.343000			"""Mis, N, F, S"""		cylindroma	cylindroma			Multiple Trichoepithelioma, Familial;Familial Cylindromatosis					108			5		0	0	1	0	0
ATP5EP2	432369	broad.mit.edu	37	13	28519639	28519639	+	RNA	SNP	T	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr13:28519639T>C	uc001uru.3	+	0		c.297T>C								Homo sapiens ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit pseudogene 2 (ATP5EP2), transcript variant 6, non-coding RNA.											ovary(1)	1						GGATCTCATTTCATGGGAAAA	0.318000														183			4		0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978222	10978222	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr12:10978222T>C	uc001qyy.1	-	0	647	c.647A>G	c.(646-648)gAc>gGc	p.D216G		NM_023921	NP_076410	Q9NYW0	T2R10_HUMAN	Homo sapiens taste receptor, type 2, member 10 (TAS2R10), mRNA.	216					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						TGTGTTGGAGTCTCTCAATCC	0.348000														125			5		0	0	1	0	0
FAM190A	401145	broad.mit.edu	37	4	91229575	91229575	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr4:91229575C>T	uc003hsv.4	+	1	480	c.140C>T	c.(139-141)tCc>tTc	p.S47F	FAM190A_uc003hsu.3_Missense_Mutation_p.S47F|FAM190A_uc010ikv.2_Non-coding_Transcript|FAM190A_uc003hsw.3_Missense_Mutation_p.S47F	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	Homo sapiens family with sequence similarity 190, member A (FAM190A), transcript variant 1, mRNA.	47	Ser-rich.									NS(2)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22						TCCTCTCCTTCCAGCACTAAC	0.453000														155			18		0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94639723	94639723	+	Nonsense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:94639723C>T	uc001dqj.4	-	22	3857	c.3488G>A	c.(3487-3489)tGg>tAg	p.W1163*	ARHGAP29_uc009wdq.1_Intron	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	Homo sapiens Rho GTPase activating protein 29 (ARHGAP29), mRNA.	1163					Rho protein signal transduction	cytosol	Rho GTPase activator activity|metal ion binding			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		AAATGTTGTCCAATGTTGAGG	0.532000														133			61		0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31122478	31122478	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr6:31122478A>G	uc003nsp.4	-	3	785	c.596T>C	c.(595-597)cTc>cCc	p.L199P	CCHCR1_uc011dne.2_Missense_Mutation_p.L110P|CCHCR1_uc003nsq.4_Missense_Mutation_p.L163P|CCHCR1_uc003nsr.4_Missense_Mutation_p.L110P|CCHCR1_uc010jsk.1_Missense_Mutation_p.L110P	NM_001105564	NP_061925	Q8TD31	CCHCR_HUMAN	Homo sapiens coiled-coil alpha-helical rod protein 1 (CCHCR1), transcript variant 1, mRNA.	110					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						CTCCCGCAGGAGCCGGACCTC	0.687000														55			4		0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2836315	2836315	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr8:2836315G>T	uc022aqr.1	-	54	8775	c.8385C>A	c.(8383-8385)aaC>aaA	p.N2795K	CSMD1_uc011kwj.2_Missense_Mutation_p.N2125K|CSMD1_uc010lrg.3_Missense_Mutation_p.N806K	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	Homo sapiens CUB and Sushi multiple domains 1 (CSMD1), mRNA.	2796	Sushi 20.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GATCAGAACAGTTCACCACTA	0.383000														27			48		6.08268e-21	6.44048e-21	1	1	0
UBE3C	9690	broad.mit.edu	37	7	157041099	157041099	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr7:157041099C>T	uc010lqs.3	+	18	2831	c.2519C>T	c.(2518-2520)gCa>gTa	p.A840V	UBE3C_uc003wni.4_Missense_Mutation_p.A203V	NM_014671	NP_055486	Q15386	UBE3C_HUMAN	Homo sapiens ubiquitin protein ligase E3C (UBE3C), mRNA.	840	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CTGCCCTTTGCAGGCTTCTTT	0.478000														68			49		0	0	1	0	0
UQCRFS1	7386	broad.mit.edu	37	19	29698692	29698692	+	Missense_Mutation	SNP	C	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:29698692C>G	uc002nsd.2	-	1	699	c.588G>C	c.(586-588)agG>agC	p.R196S		NM_006003	NP_005994	P47985	UCRI_HUMAN	Homo sapiens ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 (UQCRFS1), nuclear gene encoding mitochondrial protein, mRNA.	196	Rieske.				respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			GCTGTGGGTCCCTCAACTGTG	0.458000														208			71		0	0	1	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20187576	20187576	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chrX:20187576C>T	uc004czu.3	-	15	1387	c.1387G>A	c.(1387-1389)Gaa>Aaa	p.E463K	RPS6KA3_uc011mjk.2_Missense_Mutation_p.E433K|RPS6KA3_uc004czv.3_Missense_Mutation_p.E450K|RPS6KA3_uc011mjl.2_Missense_Mutation_p.E434K|RPS6KA3_uc011mjm.2_Missense_Mutation_p.E435K	NM_004586	NP_004577	P51812	KS6A3_HUMAN	Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3 (RPS6KA3), mRNA.	463	Protein kinase 2.				MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|axon guidance|central nervous system development|innate immune response|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity	p.E462fs(2)		breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						ATTTCAATTTCTTCTGTTGGG	0.299000														63			3		0	0	1	0	0
RPL18A	6142	broad.mit.edu	37	19	17972198	17972198	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:17972198G>A	uc002nhp.2	+	1	150	c.115G>A	c.(115-117)Gtc>Atc	p.V39I	SNORA68_uc002nhq.1_5'Flank	NM_000980	NP_000971	Q02543	RL18A_HUMAN	Homo sapiens ribosomal protein L18a (RPL18A), mRNA.	39					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|protein binding|structural constituent of ribosome			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|upper_aerodigestive_tract(1)	5						TAATCATGTCGTCGCCAAGTC	0.552000														28			20		0	0	1	0	0
FAM162A	26355	broad.mit.edu	37	3	122123174	122123174	+	Missense_Mutation	SNP	G	A	A	rs149572114	by1000genomes	TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:122123174G>A	uc003eez.3	+	2	317	c.227G>A	c.(226-228)cGc>cAc	p.R76H	FAM162A_uc011bjq.1_Missense_Mutation_p.R76H	NM_014367	NP_055182	Q96A26	F162A_HUMAN	Homo sapiens family with sequence similarity 162, member A (FAM162A), mRNA.	76						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	6						TGGTCAGGTCGCTTCAAAAAG	0.398000														131			60		0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8716284	8716285	+	Frame_Shift_Del	DEL	TC	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:8716284_8716285delTC	uc001ape.3	-	2	882_883	c.72_73delGA	c.(70-75)gagaaafs	p.E24fs	RERE_uc001apf.3_Frame_Shift_Del_p.E24fs|RERE_uc001aph.1_Frame_Shift_Del_p.E24fs	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	Homo sapiens arginine-glutamic acid dipeptide (RE) repeats (RERE), transcript variant 1, mRNA.	24					NLS-bearing substrate import into nucleus|multicellular organismal development	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TTGTCTCTTTTCtctctctctc	0.505													---	231	---	---	7	---					
PPT1	5538	broad.mit.edu	37	1	40562824	40562825	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:40562824_40562825insG	uc001cfb.2	-	0	318_319	c.86_87insC	c.(85-87)ccgfs	p.P29fs	PPT1_uc010ojg.1_Frame_Shift_Ins_p.P29fs|PPT1_uc009vwa.2_Non-coding_Transcript	NM_000310	NP_000301	P50897	PPT1_HUMAN	Homo sapiens palmitoyl-protein thioesterase 1 (PPT1), transcript variant 1, mRNA.	29					DNA fragmentation involved in apoptotic nuclear change|brain development|cofactor metabolic process|cofactor transport|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	Golgi apparatus|axon|cytosol|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity			endometrium(5)|large_intestine(1)|lung(3)|ovary(1)|stomach(1)	11	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GCGGCGCCGGCGGGTCCAGATG	0.609													---	414	---	---	13	---					
ST6GALNAC5	81849	broad.mit.edu	37	1	77334277	77334279	+	In_Frame_Del	DEL	GCA	-	-	rs113832855		TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:77334277_77334279delGCA	uc001dhi.3	+	1	286_288	c.111_113delGCA	c.(109-114)ccgcag>ccg	p.Q49del	ST6GALNAC5_uc010ori.2_In_Frame_Del_p.Q49del|ST6GALNAC5_uc009wbw.3_Non-coding_Transcript	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5), mRNA.	49	Poly-Gln.				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						AGCGGCCCCCgcagcagcagcag	0.700													---	155	---	---	8	---					
MUC1	4582	broad.mit.edu	37	1	155160853	155160854	+	In_Frame_Ins	INS	-	GGG	GGG			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:155160853_155160854insGGG	uc021pap.1	-	3	772_773	c.700_701insCCC	c.(700-702)ctt>cCCCtt	p.233_234insP	MUC1_uc001fhz.3_5'UTR|MUC1_uc001fhy.3_5'UTR|MUC1_uc010pfb.2_Intron|MUC1_uc010pfh.2_Intron|MUC1_uc010pff.2_Intron|MUC1_uc010pfi.2_Intron|MUC1_uc010pfj.2_Intron|MUC1_uc010pfk.2_Intron|MUC1_uc010pfl.2_Intron|MUC1_uc010pfc.2_Intron|MUC1_uc009wph.3_Intron|MUC1_uc010pfe.2_Intron|MUC1_uc009wpi.3_Intron|MUC1_uc010pfg.2_Intron|MUC1_uc010pfd.2_Intron|MUC1_uc009wpy.3_Intron|MUC1_uc009wpu.3_Intron|MUC1_uc010pfm.2_5'UTR|MUC1_uc001fiq.3_5'UTR|MUC1_uc009wqa.3_In_Frame_Ins_p.87_88insP|MUC1_uc010pfn.2_Intron|MUC1_uc009wpn.3_Intron|MUC1_uc010pfo.2_Intron|MUC1_uc009wpw.3_Intron|MUC1_uc001fim.3_Intron|MUC1_uc001fil.3_Intron|MUC1_uc010pfp.2_Intron|MUC1_uc001fij.3_Intron|MUC1_uc009wqc.3_Intron|MUC1_uc009wqd.3_Intron|MUC1_uc001fia.3_Intron|MUC1_uc009wqb.3_Intron|MUC1_uc009wpx.3_Intron|MUC1_uc010pfq.2_Intron|MUC1_uc001fid.3_Intron|MUC1_uc001fit.3_Intron|MUC1_uc009wpz.3_Intron|MUC1_uc001fii.3_Intron|MUC1_uc001fik.3_Intron|MUC1_uc009wpo.3_Intron|MUC1_uc010pfr.2_Intron|MUC1_uc001fih.3_Intron|MUC1_uc001fio.3_Intron|MUC1_uc009wqe.3_Intron|MUC1_uc009wpl.3_Intron|MUC1_uc009wpp.3_Intron|MUC1_uc009wpm.3_Intron|MUC1_uc009wpk.3_Intron|MUC1_uc010pfs.2_Intron|MUC1_uc001fip.3_Intron|MUC1_uc021paq.1_In_Frame_Ins_p.224_225insP|MUC1_uc009wqg.3_Intron|MUC1_uc009wqf.3_Intron|MUC1_uc001fic.3_Intron|MUC1_uc009wps.3_Intron|MUC1_uc001fie.3_Intron|MUC1_uc009wpt.3_Intron|MUC1_uc009wpq.3_Intron|MUC1_uc009wpr.3_Intron|MUC1_uc001fig.3_Intron|MUC1_uc001fif.3_Intron|MUC1_uc001fin.3_Intron|MUC1_uc009wpj.3_Intron|MUC1_uc009wpv.3_Intron|MUC1_uc001fib.3_Intron|MUC1_uc001fis.2_Intron|DM075093_uc021par.1_5'Flank	NM_001204286	NP_001191215	P15941	MUC1_HUMAN	Homo sapiens mucin 1, cell surface associated (MUC1), transcript variant 10, mRNA.	1004	42 X 20 AA approximate tandem repeats of P-A-P-G-S-T-A-P-P-A-H-G-V-T-S-A-P-D-T-R.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|skin(2)	10	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ATGGCTGGCAAGGGTGGTAGGA	0.559			T	IGH@	B-NHL								---	319	---	---	7	---					
TRMT1L	81627	broad.mit.edu	37	1	185119607	185119608	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr1:185119607_185119608insA	uc001grf.4	-	2	635_636	c.363_364insT	c.(361-366)tgtccafs	p.C121fs	TRMT1L_uc010pon.2_5'UTR	NM_030934	NP_001189352	Q7Z2T5	TRM1L_HUMAN	Homo sapiens TRM1 tRNA methyltransferase 1-like (TRMT1L), transcript variant 1, mRNA.	121						intracellular	RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	21						GGGCACAATGGACAAGCCTGTC	0.376													---	113	---	---	8	---					
ABCG8	64241	broad.mit.edu	37	2	44102406	44102407	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr2:44102406_44102407insG	uc002rtq.3	+	10	1700_1701	c.1610_1611insG	c.(1609-1611)ctgfs	p.L537fs	ABCG8_uc010yoa.2_Frame_Shift_Ins_p.L536fs	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	Homo sapiens ATP-binding cassette, sub-family G (WHITE), member 8 (ABCG8), mRNA.	537	ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTGGTGTGGCTGGTGGTCTTCT	0.609													---	141	---	---	7	---					
ANKRD36B	57730	broad.mit.edu	37	2	98129746	98129746	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr2:98129746delG	uc010yvc.1	-	37	2982	c.2702delC	c.(2701-2703)acafs	p.T901fs	ANKRD36B_uc010fid.1_5'Flank|ANKRD36B_uc002sxx.1_5'Flank|ANKRD36B_uc010yvd.1_5'UTR	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	Homo sapiens ankyrin repeat domain 36B (ANKRD36B), mRNA.	901																	TTGCTCTTCTGTTATTCTTAA	0.333													---	1408	---	---	9	---					
IL1RL1	9173	broad.mit.edu	37	2	102959759	102959760	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr2:102959759_102959760insG	uc002tbu.1	+	7	1125_1126	c.854_855insG	c.(853-855)atgfs	p.M285fs	IL1RL1_uc010ywa.2_Frame_Shift_Ins_p.M168fs|IL18R1_uc002tbw.4_Intron|IL1RL1_uc002tbv.3_Frame_Shift_Ins_p.M285fs	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	Homo sapiens interleukin 1 receptor-like 1 (IL1RL1), transcript variant 1, mRNA.	285	Ig-like C2-type 3.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						TGTCTAGACATGGTTTTAAGAA	0.455													---	350	---	---	14	---					
RGPD4	285190	broad.mit.edu	37	2	108487353	108487354	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr2:108487353_108487354insA	uc010ywk.2	+	19	2975_2976	c.2893_2894insA	c.(2893-2895)caafs	p.Q965fs	RGPD4_uc002tdu.3_Frame_Shift_Ins_p.Q152fs|RGPD4_uc010ywl.2_Non-coding_Transcript	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	Homo sapiens RANBP2-like and GRIP domain containing 4 (RGPD4), mRNA.	965					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GATTTTTGGCCAAACAAGTAGC	0.401													---	1007	---	---	8	---					
KLF15	28999	broad.mit.edu	37	3	126070866	126070867	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr3:126070866_126070867insG	uc011bkk.1	-	1	1081_1082	c.899_900insC	c.(898-900)cctfs	p.P300fs		NM_014079	NP_054798	Q9UIH9	KLF15_HUMAN	Homo sapiens Kruppel-like factor 15 (KLF15), mRNA.	300						nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(7)|ovary(2)|skin(2)	12				GBM - Glioblastoma multiforme(114;0.147)		GGAGACCGGCAGGGCCAGGCCC	0.584													---	448	---	---	8	---					
NCAPG	64151	broad.mit.edu	37	4	17844972	17844973	+	Frame_Shift_Ins	INS	-	A	A	rs75077775		TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr4:17844972_17844973insA	uc003gpp.3	+	20	3148_3149	c.2972_2973insA	c.(2971-2973)ccafs	p.P991fs	NCAPG_uc011bxj.2_Frame_Shift_Ins_p.P500fs|LCORL_uc021xmq.1_3'UTR|LCORL_uc003gpq.3_3'UTR|LCORL_uc011bxk.2_3'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	Homo sapiens non-SMC condensin I complex, subunit G (NCAPG), mRNA.	991					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		ATGAGACTACCAAGACGAGCCA	0.366													---	320	---	---	7	---					
OCLN	100506658	broad.mit.edu	37	5	68840857	68840857	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr5:68840857delA	uc003jwu.3	+	5	1600	c.1164delA	c.(1162-1164)ggafs	p.G388fs	OCLN_uc003jwv.4_Frame_Shift_Del_p.G388fs|OCLN_uc021xzq.1_Frame_Shift_Del_p.G137fs|OCLN_uc021xzr.1_Non-coding_Transcript|OCLN_uc021xzs.1_Frame_Shift_Del_p.G137fs|OCLN_uc021xzt.1_Frame_Shift_Del_p.G66fs	NM_002538	NP_001192184	Q16625	OCLN_HUMAN	Homo sapiens occludin (OCLN), transcript variant 1, mRNA.	388					cellular component disassembly involved in apoptosis|protein complex assembly	integral to membrane|tight junction	protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|liver(1)|prostate(1)|skin(1)	6		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		GAAGAGCAGGAAGGTCAAAGA	0.512													---	1552	---	---	8	---					
CAMK4	814	broad.mit.edu	37	5	110560256	110560257	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr5:110560256_110560257insG	uc003kpf.3	+	0	310_311	c.75_76insG	c.(73-78)accgcgfs	p.T25fs	CAMK4_uc010jbv.3_5'UTR	NM_001744	NP_001735	Q16566	KCC4_HUMAN	Homo sapiens calcium/calmodulin-dependent protein kinase IV (CAMK4), mRNA.	25					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		CCCCGGGGACCGCGAGCCTCGT	0.673													---	194	---	---	8	---					
SEMA6A	57556	broad.mit.edu	37	5	115782974	115782975	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr5:115782974_115782975insG	uc003krx.4	-	19	3187_3188	c.2478_2479insC	c.(2476-2481)cccagcfs	p.P826fs	SEMA6A_uc010jck.3_Frame_Shift_Ins_p.P809fs|SEMA6A_uc011cwe.2_Frame_Shift_Ins_p.P188fs|SEMA6A_uc003krv.4_Frame_Shift_Ins_p.P236fs|SEMA6A_uc003krw.4_Frame_Shift_Ins_p.P286fs|SEMA6A_uc010jcj.3_Frame_Shift_Ins_p.P353fs	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	Homo sapiens sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A (SEMA6A), mRNA.	809					apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GGGATGTGGCTGGGGGAGGCCC	0.639													---	104	---	---	9	---					
C7orf25	79020	broad.mit.edu	37	7	42949523	42949524	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr7:42949523_42949524delCT	uc003thx.4	-	1	1635_1636	c.1150_1151delAG	c.(1150-1152)aggfs	p.R384fs	C7orf25_uc010kxq.3_Frame_Shift_Del_p.R326fs|C7orf25_uc010kxr.3_Frame_Shift_Del_p.R384fs|C7orf25_uc022ace.1_Frame_Shift_Del_p.R326fs	NM_001099858	NP_076959	Q9BPX7	CG025_HUMAN	Homo sapiens chromosome 7 open reading frame 25 (C7orf25), transcript variant 1, mRNA.	326								p.R326fs*6(1)		endometrium(6)|kidney(1)|large_intestine(7)|lung(2)|skin(1)	17						CACAGTGGCCCTCTCTCTCTCC	0.455													---	182	---	---	9	---					
SMO	6608	broad.mit.edu	37	7	128846110	128846111	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr7:128846110_128846111insC	uc003vor.3	+	4	1320_1321	c.1040_1041insC	c.(1039-1041)ggcfs	p.G347fs	SMO_uc003vos.3_Frame_Shift_Ins_p.G22fs	NM_005631	NP_005622	Q99835	SMO_HUMAN	Homo sapiens smoothened, frizzled family receptor (SMO), mRNA.	347					adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			biliary_tract(1)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(14)|liver(1)|lung(11)|pancreas(2)|prostate(1)|skin(20)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AAAGCCCTGGGCACCACCTACC	0.569			Mis		skin basal cell								---	213	---	---	7	---					
SHH	6469	broad.mit.edu	37	7	155604741	155604742	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr7:155604741_155604742insC	uc003wmk.1	-	0	226_227	c.75_76insG	c.(73-78)ggaccgfs	p.G25fs	SHH_uc003wmh.1_5'Flank|SHH_uc003wmi.1_5'Flank|SHH_uc003wmj.1_5'Flank	NM_000193	NP_000184	Q15465	SHH_HUMAN	Homo sapiens sonic hedgehog (SHH), mRNA.	25					CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of T cell differentiation in thymus|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|kidney(1)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCCTGCCCGGTCCGCACGCCA	0.609													---	185	---	---	8	---					
TG	7038	broad.mit.edu	37	8	133913781	133913782	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr8:133913781_133913782insC	uc003ytw.3	+	15	3658_3659	c.3617_3618insC	c.(3616-3618)ggcfs	p.G1206fs	TG_uc010mdw.3_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	1206	Thyroglobulin type-1 10.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTGACCGGGGGCCAGCCCGCCT	0.619													---	139	---	---	7	---					
STAM	8027	broad.mit.edu	37	10	17756602	17756603	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr10:17756602_17756603insC	uc001ipj.2	+	13	1661_1662	c.1446_1447insC	c.(1444-1449)cctcctfs	p.P482fs	STAM_uc010qcf.2_Frame_Shift_Ins_p.P371fs|STAM_uc009xjw.2_Frame_Shift_Ins_p.P140fs	NM_003473	NP_003464	Q92783	STAM1_HUMAN	Homo sapiens signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 (STAM), transcript variant 1, mRNA.	482					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	26						TATATAGTCCTCCTCCTGCCGC	0.470													---	109	---	---	7	---					
SPON1	10418	broad.mit.edu	37	11	14276276	14276277	+	Splice_Site	DEL	GT	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:14276276_14276277delGT	uc001mle.3	+	9	1357	c.1089_splice	c.e9+1	p.E363_splice		NM_006108	NP_006099	Q9HCB6	SPON1_HUMAN	Homo sapiens spondin 1, extracellular matrix protein (SPON1), mRNA.	364	Spondin.				cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GACCTATGAGGTGTGTGTGTGT	0.594													---	119	---	---	7	---					
DGKZ	8525	broad.mit.edu	37	11	46398729	46398730	+	Frame_Shift_Del	DEL	CT	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:46398729_46398730delCT	uc001ncn.1	+	25	2998_2999	c.2873_2874delCT	c.(2872-2874)cctfs	p.P958fs	DGKZ_uc001nch.2_Frame_Shift_Del_p.P786fs|DGKZ_uc010rgq.2_Frame_Shift_Del_p.P752fs|DGKZ_uc010rgr.2_Frame_Shift_Del_p.P774fs|DGKZ_uc001ncj.2_Frame_Shift_Del_p.P736fs|DGKZ_uc001nck.2_Frame_Shift_Del_p.P548fs|DGKZ_uc001ncm.2_Frame_Shift_Del_p.P769fs|DGKZ_uc001ncl.2_Frame_Shift_Del_p.P770fs|DGKZ_uc009yky.1_Frame_Shift_Del_p.P770fs|DGKZ_uc010rgs.1_Frame_Shift_Del_p.P747fs	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	Homo sapiens diacylglycerol kinase, zeta (DGKZ), transcript variant 4, mRNA.	958					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein C-terminus binding|protein binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CCCACTTCCCCTCTCCCCACCT	0.624													---	191	---	---	7	---					
FRMD8	83786	broad.mit.edu	37	11	65161559	65161560	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:65161559_65161560insG	uc001odu.4	+	4	595_596	c.403_404insG	c.(403-405)cggfs	p.R135fs	FRMD8_uc009yqj.3_Frame_Shift_Ins_p.R79fs|FRMD8_uc010rof.2_Frame_Shift_Ins_p.R101fs	NM_031904	NP_114110	Q9BZ67	FRMD8_HUMAN	Homo sapiens FERM domain containing 8 (FRMD8), mRNA.	135	FERM.					cytoskeleton	binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|urinary_tract(1)	17						CCCAAAGCGGCGGGAGCTCCAG	0.658													---	160	---	---	7	---					
CATSPER1	117144	broad.mit.edu	37	11	65792709	65792709	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:65792709delA	uc001ogt.3	-	0	1280	c.1142delT	c.(1141-1143)gtcfs	p.V381fs		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	Homo sapiens cation channel, sperm associated 1 (CATSPER1), mRNA.	381					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						CTGGGTATGGACTTTTTTGGA	0.537													---	539	---	---	7	---					
C11orf80	79703	broad.mit.edu	37	11	66555695	66555696	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr11:66555695_66555696insA	uc021qmd.1	+	4	595_596	c.588_589insA	c.(586-591)tattctfs	p.Y196fs	C11orf80_uc010rpk.2_Frame_Shift_Ins_p.Y30fs	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	Homo sapiens chromosome 11 open reading frame 80 (C11orf80), mRNA.	41										autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	14						AAGGCAGCTATTCTCAGGATAT	0.401													---	390	---	---	122	---					
OSBPL8	114882	broad.mit.edu	37	12	76763581	76763582	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr12:76763581_76763582insC	uc001sye.1	-	19	2555_2556	c.2075_2076insG	c.(2074-2076)cgafs	p.R692fs	OSBPL8_uc001syf.1_Frame_Shift_Ins_p.R650fs|OSBPL8_uc001syg.1_Frame_Shift_Ins_p.R650fs|OSBPL8_uc001syh.1_Frame_Shift_Ins_p.R667fs	NM_020841	NP_001003712	Q9BZF1	OSBL8_HUMAN	Homo sapiens oxysterol binding protein-like 8 (OSBPL8), transcript variant 1, mRNA.	692					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						CATTTATGGCTCGAGTTACCCG	0.366													---	229	---	---	7	---					
RB1	5925	broad.mit.edu	37	13	49039350	49039359	+	Frame_Shift_Del	DEL	TTGTCACCAA	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr13:49039350_49039359delTTGTCACCAA	uc001vcb.3	+	22	2501_2510	c.2335_2344delTTGTCACCAA	c.(2335-2346)ttgtcaccaatafs	p.L779fs		NM_000321	NP_000312	P06400	RB_HUMAN	Homo sapiens retinoblastoma 1 (RB1), mRNA.	779	Domain C; mediates interaction with E4F1.|Interaction with LIMD1.				G1 phase of mitotic cell cycle|Ras protein signal transduction|S phase of mitotic cell cycle|androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of S phase of mitotic cell cycle|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|sister chromatid biorientation	PML body|Rb-E2F complex|SWI/SNF complex|chromatin	DNA binding|androgen receptor binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(11)|p.I782fs*28(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCCCCCTACCTTGTCACCAATACCTCACAT	0.381		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			---	40	---	---	38	---					
CHRFAM7A	89832	broad.mit.edu	37	15	30659650	30659651	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr15:30659650_30659651insG	uc001zdt.1	-	8	1256_1257	c.690_691insC	c.(688-693)cacgacfs	p.H230fs	DKFZP434L187_uc001zds.2_Intron|CHRFAM7A_uc001zdu.1_Frame_Shift_Ins_p.H139fs|CHRFAM7A_uc010azn.2_Frame_Shift_Ins_p.H139fs	NM_139320	NP_683709	Q494W8	CRFM7_HUMAN	Homo sapiens CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion (CHRFAM7A), transcript variant 1, mRNA.	230						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			large_intestine(3)|lung(1)|skin(2)	6		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CCGTCGGGGTCGTGGTGGTGGT	0.599													---	697	---	---	8	---					
MLYCD	23417	broad.mit.edu	37	16	83941751	83941752	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr16:83941751_83941752insA	uc002fgz.3	+	2	682_683	c.662_663insA	c.(661-663)gtafs	p.V221fs		NM_012213	NP_036345	O95822	DCMC_HUMAN	Homo sapiens malonyl-CoA decarboxylase (MLYCD), nuclear gene encoding mitochondrial protein, mRNA.	221					acyl-CoA metabolic process|fatty acid biosynthetic process	mitochondrion|peroxisome	malonyl-CoA decarboxylase activity|methylmalonyl-CoA decarboxylase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						GTGCATCCTGTAAAAAACTGGA	0.500													---	33	---	---	58	---					
RAI1	10743	broad.mit.edu	37	17	17700804	17700805	+	Frame_Shift_Ins	INS	-	C	C	rs148698066		TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr17:17700804_17700805insC	uc002grm.3	+	2	5011_5012	c.4542_4543insC	c.(4540-4545)aggcccfs	p.R1514fs	RAI1_uc002grn.1_Frame_Shift_Ins_p.R1514fs	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	Homo sapiens retinoic acid induced 1 (RAI1), mRNA.	1514						cytoplasm|nucleus	zinc ion binding	p.P1515S(2)|p.P1515F(2)		breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		CGGAGGGCAGGCCCTGCCAGCC	0.649													---	191	---	---	10	---					
LGALS9C	654346	broad.mit.edu	37	17	18387252	18387252	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr17:18387252delG	uc002gtw.3	+	1	173	c.103delG	c.(103-105)gggfs	p.G35fs	LGALS9C_uc010vyb.2_Intron	NM_001040078	NP_001035167	Q6DKI2	LEG9C_HUMAN	Homo sapiens lectin, galactoside-binding, soluble, 9C (LGALS9C), mRNA.	35	Galectin 1.						sugar binding			NS(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(2)	7						CACTGTCAATGGGGCCGTTCT	0.567													---	1759	---	---	7	---					
NPTX1	4884	broad.mit.edu	37	17	78449424	78449425	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr17:78449424_78449425insG	uc002jyp.1	-	1	696_697	c.538_539insC	c.(538-540)cggfs	p.R180fs		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	Homo sapiens neuronal pentraxin I (NPTX1), mRNA.	180					central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)	11	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GGTGTTCACCCGGGACAGCACC	0.639													---	86	---	---	8	---					
C3	718	broad.mit.edu	37	19	6679165	6679166	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:6679165_6679166insC	uc002mfm.3	-	37	4662_4663	c.4600_4601insG	c.(4600-4602)gacfs	p.D1534fs		NM_000064	NP_000055	P01024	CO3_HUMAN	Homo sapiens complement component 3 (C3), mRNA.	1534	NTR.				G-protein coupled receptor protein signaling pathway|complement activation, alternative pathway|complement activation, classical pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACAGGCCTTGTCCAGCCGTTCT	0.550													---	259	---	---	7	---					
PODNL1	79883	broad.mit.edu	37	19	14044085	14044087	+	In_Frame_Del	DEL	CCC	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:14044085_14044087delCCC	uc002mxr.3	-	7	1244_1246	c.970_972delGGG	c.(970-972)gggdel	p.G324del	PODNL1_uc010xni.2_In_Frame_Del_p.G242del|PODNL1_uc010xnj.2_In_Frame_Del_p.G322del|PODNL1_uc002mxs.3_In_Frame_Del_p.G233del	NM_024825	NP_079101	Q6PEZ8	PONL1_HUMAN	Homo sapiens podocan-like 1 (PODNL1), transcript variant 1, mRNA.	324	Leu-rich.					proteinaceous extracellular matrix				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|skin(1)	8			OV - Ovarian serous cystadenocarcinoma(19;5.26e-23)			GCCCTGAGCTCCCCAGCTGGTTG	0.714													---	3	---	---	3	---					
SLC27A5	10998	broad.mit.edu	37	19	59022739	59022740	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr19:59022739_59022740insC	uc002qtc.2	-	0	693_694	c.583_584insG	c.(583-585)gccfs	p.A195fs		NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	Homo sapiens solute carrier family 27 (fatty acid transporter), member 5 (SLC27A5), mRNA.	195					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		GCCCAGCTTGGCCAGCCCCAGC	0.688													---	164	---	---	8	---					
LPIN3	64900	broad.mit.edu	37	20	39984606	39984608	+	In_Frame_Del	DEL	TTG	-	-			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr20:39984606_39984608delTTG	uc010ggh.3	+	13	1829_1831	c.1738_1740delTTG	c.(1738-1740)ttgdel	p.L580del	LPIN3_uc002xjx.3_In_Frame_Del_p.L579del|LPIN3_uc010zwf.2_Non-coding_Transcript	NM_022896	NP_075047	Q9BQK8	LPIN3_HUMAN	Homo sapiens lipin 3 (LPIN3), mRNA.	579					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GATCCCCTCCTTGccaccctcca	0.586													---	279	---	---	7	---					
KCNQ2	3785	broad.mit.edu	37	20	62076054	62076055	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr20:62076054_62076055insC	uc002yey.1	-	3	824_825	c.647_648insG	c.(646-648)ggcfs	p.G216fs	KCNQ2_uc002yez.1_Frame_Shift_Ins_p.G216fs|KCNQ2_uc002yfa.1_Frame_Shift_Ins_p.G216fs|KCNQ2_uc002yfb.1_Frame_Shift_Ins_p.G216fs|KCNQ2_uc011aax.1_Frame_Shift_Ins_p.G216fs|KCNQ2_uc002yfc.1_Frame_Shift_Ins_p.G216fs	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	Homo sapiens potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), transcript variant 1, mRNA.	216					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GCTTCCAGGTGCCTCCCCGCCG	0.688													---	142	---	---	8	---					
RIMBP3	85376	broad.mit.edu	37	22	20458628	20458629	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chr22:20458628_20458629insG	uc002zsd.4	-	0	3158_3159	c.2673_2674insC	c.(2671-2676)tccaacfs	p.S891fs	RN7SK_uc021wlw.1_5'Flank	NM_015672	NP_056487			Homo sapiens RIMS binding protein 3 (RIMBP3), mRNA.											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			TCCACGAAGTTGGAGGGCACCA	0.604													---	594	---	---	10	---					
FAM47B	170062	broad.mit.edu	37	X	34961067	34961068	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chrX:34961067_34961068insC	uc004ddi.2	+	0	155_156	c.119_120insC	c.(118-120)ttcfs	p.F40fs		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	Homo sapiens family with sequence similarity 47, member B (FAM47B), mRNA.	40										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CGCCTGAGGTTCCCGCCTGTGG	0.594													---	215	---	---	8	---					
RAB40A	142684	broad.mit.edu	37	X	102755468	102755469	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chrX:102755468_102755469insC	uc022cbs.1	-	0	216_217	c.216_217insG	c.(214-219)gggcagfs	p.G72fs	RAB40A_uc004ekk.3_Frame_Shift_Ins_p.G72fs	NM_080879	NP_543155	Q8WXH6	RB40A_HUMAN	Homo sapiens RAB40A, member RAS oncogene family (RAB40A), mRNA.	72					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	12						AATCTTCCCTGCCCCGACGTAT	0.569													---	192	---	---	7	---					
USP26	83844	broad.mit.edu	37	X	132161205	132161205	+	Frame_Shift_Del	DEL	A	-	-	rs61758857		TCGA-KO-8404-01A-11D-2310-10	TCGA-KO-8404-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	af8dd8cc-ebaa-432c-bcd8-2d792de62be1	d957b0fd-8a5b-410b-b85b-0b8985321ab0	g.chrX:132161205delA	uc011mvf.2	-	0	1096	c.1044delT	c.(1042-1044)tttfs	p.F348fs	USP26_uc010nrm.1_Frame_Shift_Del_p.F348fs	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	Homo sapiens ubiquitin specific peptidase 26 (USP26), mRNA.	348					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity	p.F348fs*7(2)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|liver(2)|lung(18)|ovary(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	60	Acute lymphoblastic leukemia(192;0.000127)					AGGTATCTTTAAAAAAAAGTA	0.388													---	134	---	---	7	---					
