Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NCL	4691	broad.mit.edu	37	2	232322444	232322444	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr2:232322444C>T	uc002vru.3	-	8	1498	c.1357G>A	c.(1357-1359)Gag>Aag	p.E453K	SNORA75_uc002vrv.1_5'Flank|SNORD20_uc002vrw.1_5'Flank	NM_005381	NP_005372	P19338	NUCL_HUMAN	Homo sapiens nucleolin (NCL), mRNA.	453	RRM 2.				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	RNA binding|nucleotide binding|protein C-terminus binding|telomeric DNA binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		CCATCGATCTCTGTTCCCTGC	0.393000														100			4		0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26465370	26465370	+	Silent	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr11:26465370C>T	uc001mqt.4	+	2	445	c.300C>T	c.(298-300)agC>agT	p.S100S	ANO3_uc010rdr.2_Silent_p.S84S	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	Homo sapiens anoctamin 3 (ANO3), mRNA.	100						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						CTGACCTCAGCGATTTTTGTT	0.328000														153			7		0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29416536	29416536	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr2:29416536C>T	uc002rmy.3	-	28	5369	c.4417G>A	c.(4417-4419)Ggg>Agg	p.G1473R	ALK_uc010ymo.2_Missense_Mutation_p.G405R	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), mRNA.	1473					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.V1471fs*45(1)	ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ACGTGTCCCCCTTCCACGGCC	0.582000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome					108			7		0	0	1	0	0
KIF17	57576	broad.mit.edu	37	1	21014271	21014271	+	Silent	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr1:21014271C>T	uc001bdr.4	-	7	1666	c.1548G>A	c.(1546-1548)caG>caA	p.Q516Q	KIF17_uc001bdp.4_5'Flank|KIF17_uc009vpx.3_Intron|KIF17_uc001bds.4_Silent_p.Q516Q	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	Homo sapiens kinesin family member 17 (KIF17), transcript variant 1, mRNA.	516					microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TGGAGGAAACCTGAGTCTTGG	0.542000														57			5		0	0	1	0	0
C19orf18	147685	broad.mit.edu	37	19	58472845	58472845	+	Missense_Mutation	SNP	T	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr19:58472845T>G	uc002qqv.3	-	4	548	c.446A>C	c.(445-447)gAt>gCt	p.D149A		NM_152474	NP_689687	Q8NEA5	CS018_HUMAN	Homo sapiens chromosome 19 open reading frame 18 (C19orf18), mRNA.	149						integral to membrane				large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)		CTCTTCTTCATCTCCTAATAA	0.463000														122			13		0	0	1	0	0
MYF6	4618	broad.mit.edu	37	12	81102660	81102660	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr12:81102660G>A	uc001szf.2	+	2	741	c.650G>A	c.(649-651)cGa>cAa	p.R217Q		NM_002469	NP_002460	P23409	MYF6_HUMAN	Homo sapiens myogenic factor 6 (herculin) (MYF6), mRNA.	217					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(12)|skin(1)	26						AGTAGCCTTCGATGCCTTTCT	0.522000														85			52		0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22291963	22291963	+	Silent	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr11:22291963G>A	uc001mqi.2	+	17	2321	c.2004G>A	c.(2002-2004)ggG>ggA	p.G668G	ANO5_uc001mqj.2_Silent_p.G667G	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	Homo sapiens anoctamin 5 (ANO5), transcript variant 1, mRNA.	668						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity	p.L667V(1)		breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GACCCCTTGGGCTTTTCTATG	0.418000														119			7		0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356435	42356435	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr14:42356435A>G	uc001wvm.3	+	2	1805	c.607A>G	c.(607-609)Aca>Gca	p.T203A	LRFN5_uc010ana.3_Missense_Mutation_p.T203A	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	Homo sapiens leucine rich repeat and fibronectin type III domain containing 5 (LRFN5), mRNA.	203						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GTTAGATGTGACATCAAATAA	0.428000										HNSCC(30;0.082)				164			5		0	0	1	0	0
IMMT	10989	broad.mit.edu	37	2	86374840	86374840	+	Silent	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr2:86374840C>T	uc002sqz.4	-	12	1906	c.1518G>A	c.(1516-1518)aaG>aaA	p.K506K	IMMT_uc002sqy.4_Silent_p.K247K|IMMT_uc010yte.2_Silent_p.K459K|IMMT_uc002srb.4_Silent_p.K495K|IMMT_uc002sra.4_Silent_p.K505K|IMMT_uc010ytd.2_Silent_p.K494K|IMMT_uc002src.1_Silent_p.K242K	NM_006839	NP_006830	Q16891	IMMT_HUMAN	Homo sapiens inner membrane protein, mitochondrial (IMMT), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	506						integral to mitochondrial inner membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CAAATTCAGACTTCAATTCCT	0.488000														61			3		0	0	1	0	0
GTF3C2	2976	broad.mit.edu	37	2	27550102	27550102	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr2:27550102T>C	uc002rju.1	-	17	2889	c.2492A>G	c.(2491-2493)gAg>gGg	p.E831G	MPV17_uc002rjt.3_5'Flank|GTF3C2_uc010eyy.1_Missense_Mutation_p.E275G|GTF3C2_uc002rjv.1_Missense_Mutation_p.E820G|GTF3C2_uc002rjw.1_Missense_Mutation_p.E820G	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	Homo sapiens general transcription factor IIIC, polypeptide 2, beta 110kDa (GTF3C2), transcript variant 1, mRNA.	820						transcription factor TFIIIC complex				central_nervous_system(4)|endometrium(6)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	38	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCTCTCCCTCCTGCATGCG	0.532000														19			3		0	0	1	0	0
ANTXR2	118429	broad.mit.edu	37	4	80954628	80954628	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr4:80954628G>A	uc003hlz.4	-	8	1557	c.794C>T	c.(793-795)aCg>aTg	p.T265M	ANTXR2_uc003hly.4_Missense_Mutation_p.T265M|ANTXR2_uc003hlx.1_Non-coding_Transcript|ANTXR2_uc010ijn.3_Intron	NM_001145794	NP_001139266	P58335	ANTR2_HUMAN	Homo sapiens anthrax toxin receptor 2 (ANTXR2), transcript variant 2, mRNA.	265						endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						GGACCTACTCGTTGTATATGT	0.393000									Juvenile Hyaline Fibromatosis					304			24		0	0	1	0	0
EARS2	124454	broad.mit.edu	37	16	23546345	23546345	+	Silent	SNP	C	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr16:23546345C>A	uc002dlu.3	-	3	854	c.822G>T	c.(820-822)ctG>ctT	p.L274L	EARS2_uc002dlr.4_Non-coding_Transcript|EARS2_uc002dls.4_Non-coding_Transcript|EARS2_uc002dlt.4_Silent_p.L274L	NM_001083614	NP_001077083	Q5JPH6	SYEM_HUMAN	Homo sapiens glutamyl-tRNA synthetase 2, mitochondrial (putative) (EARS2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	274					glutamyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|RNA binding|glutamate-tRNA ligase activity			central_nervous_system(1)|endometrium(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	8				GBM - Glioblastoma multiforme(48;0.0353)	L-Glutamic Acid(DB00142)	GGAGCAGGGGCAGGTGGGCGA	0.627000														58			64		1.12115e-39	1.19847e-39	1	1	0
GPR158	57512	broad.mit.edu	37	10	25887315	25887315	+	Silent	SNP	C	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr10:25887315C>G	uc001isj.3	+	10	2820	c.2760C>G	c.(2758-2760)acC>acG	p.T920T	GPR158_uc001isk.3_Silent_p.T295T	NM_020752	NP_065803	Q5T848	GP158_HUMAN	Homo sapiens G protein-coupled receptor 158 (GPR158), mRNA.	920						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CTGGGAAAACCCAAACAGCAG	0.438000														28			6		0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012270	29012270	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr6:29012270G>A	uc003nlw.2	-	0	683	c.683C>T	c.(682-684)aCg>aTg	p.T228M	LOC100129636_uc021ytq.1_Intron	NM_030903	NP_112165	Q9Y3N9	OR2W1_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily W, member 1 (OR2W1), mRNA.	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T228T(1)		endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						TTTTGACTTCGTTCTCAGCAC	0.393000														36			141		0	0	1	0	0
PELP1	27043	broad.mit.edu	37	17	4575433	4575433	+	Silent	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr17:4575433C>T	uc002fyi.4	-	15	3079	c.2853G>A	c.(2851-2853)gaG>gaA	p.E951E	PELP1_uc010vsf.2_Silent_p.E804E	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	Homo sapiens proline, glutamate and leucine rich protein 1 (PELP1), mRNA.	951	Glu-rich.				transcription, DNA-dependent	MLL1 complex|cytoplasm	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						cttcctcctcctcatcctcct	0.498000														76			3		0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200136984	200136984	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr2:200136984C>T	uc002uuy.2	-	10	2969	c.2152G>A	c.(2152-2154)Gaa>Aaa	p.E718K	SATB2_uc010fsq.2_Missense_Mutation_p.E600K|SATB2_uc002uva.2_Missense_Mutation_p.E718K|SATB2_uc002uuz.2_Missense_Mutation_p.E718K	NM_001172509	NP_056080	Q9UPW6	SATB2_HUMAN	Homo sapiens SATB homeobox 2 (SATB2), transcript variant 1, mRNA.	718						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TCAGCATTTTCCTCCTCAGCC	0.502000														42			5		0	0	1	0	0
ORAOV1	220064	broad.mit.edu	37	11	69482297	69482297	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr11:69482297A>G	uc001opc.3	-	4	562	c.404T>C	c.(403-405)cTt>cCt	p.L135P	ORAOV1_uc010rqi.1_Intron|ORAOV1_uc009ysm.3_Non-coding_Transcript|ORAOV1_uc001opd.3_Missense_Mutation_p.L76P	NM_153451	NP_703152	Q8WV07	ORAV1_HUMAN	Homo sapiens oral cancer overexpressed 1 (ORAOV1), mRNA.	135										NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			TCAAAATGAAAGTCCGGAACC	0.428000														94			4		0	0	1	0	0
FAM154B	283726	broad.mit.edu	37	15	82564044	82564044	+	Missense_Mutation	SNP	C	T	T	rs150372195		TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr15:82564044C>T	uc002bgv.3	+	1	223	c.154C>T	c.(154-156)Cgg>Tgg	p.R52W	FAM154B_uc010unr.2_Missense_Mutation_p.R37W|FAM154B_uc010uns.2_Non-coding_Transcript	NM_001008226	NP_001008227	Q658L1	F154B_HUMAN	Homo sapiens family with sequence similarity 154, member B (FAM154B), mRNA.	52										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						TACCTACAAACGGGATTTGAA	0.408000														285			12		0	0	1	0	0
UBE2MP1	606551	broad.mit.edu	37	16	34404145	34404145	+	RNA	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr16:34404145G>A	uc002edv.1	-	0		c.618C>T								Homo sapiens ubiquitin-conjugating enzyme E2M pseudogene 1 (UBE2MP1), non-coding RNA.																		AACAGCTGCCGGTTGTTCTGC	0.552000														76			3		0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109698465	109698465	+	Silent	SNP	A	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chrX:109698465A>G	uc004eor.2	+	3	4329	c.4083A>G	c.(4081-4083)aaA>aaG	p.K1361K		NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	Homo sapiens retrotransposon gag domain containing 1 (RGAG1), mRNA.	1361										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						ACTACCTGAAAGAGCATGGAG	0.483000														119			4		0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78086495	78086495	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr17:78086495G>T	uc002jxp.3	+	12	2240	c.1873G>T	c.(1873-1875)Gcc>Tcc	p.A625S	GAA_uc002jxo.3_Missense_Mutation_p.A625S|GAA_uc002jxq.3_Missense_Mutation_p.A625S	NM_000152	NP_001073272	P10253	LYAG_HUMAN	Homo sapiens glucosidase, alpha; acid (GAA), transcript variant 1, mRNA.	625					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGAGCAGCTCGCCTCCTCCGT	0.687000														36			3		6.4e-05	6.61333e-05	1	1	0
SLC20A2	6575	broad.mit.edu	37	8	42294728	42294728	+	Silent	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr8:42294728C>T	uc003xpe.3	-	7	1671	c.1302G>A	c.(1300-1302)tcG>tcA	p.S434S	SLC20A2_uc010lxl.3_Silent_p.S434S|SLC20A2_uc010lxm.3_Silent_p.S434S|SLC20A2_uc011lcu.2_Silent_p.S236S	NM_006749	NP_006740	Q08357	S20A2_HUMAN	Homo sapiens solute carrier family 20 (phosphate transporter), member 2 (SLC20A2), mRNA.	434					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TACAGTAGCTCGAGTAGCTGT	0.652000														41			5		0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195509957	195509957	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr3:195509957A>G	uc021xjp.1	-	1	8650	c.8494T>C	c.(8494-8496)Tct>Cct	p.S2832P	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	575					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACAGGAAGAGAGGTGGCATGA	0.592000														13			5		0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96761794	96761794	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr4:96761794G>A	uc003htr.4	+	0	556	c.493G>A	c.(493-495)Gtc>Atc	p.V165I		NM_005390	NP_005381	P29803	ODPAT_HUMAN	Homo sapiens pyruvate dehydrogenase (lipoamide) alpha 2 (PDHA2), mRNA.	165					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity	p.V165I(2)		NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CAATGGCATCGTCGGTGCACA	0.507000														74			13		0	0	1	0	0
TAS2R50	259296	broad.mit.edu	37	12	11139408	11139408	+	Missense_Mutation	SNP	C	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr12:11139408C>A	uc001qzl.2	-	0	104	c.52G>T	c.(52-54)Gtt>Ttt	p.V18F	PRH1_uc001qzb.4_Intron|TAS2R14_uc021qve.1_Intron|PRH1_uc021qvg.1_Intron|PRB4_uc001qzf.1_Intron|TAS2R14_uc001qzj.3_Intron	NM_176890	NP_795371	P59544	T2R50_HUMAN	Homo sapiens taste receptor, type 2, member 50 (TAS2R50), mRNA.	18					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						TTTCCGAGAACAAATAAAACC	0.338000														134			7		0.000157383	0.000157383	1	1	0
PPP1R13B	23368	broad.mit.edu	37	14	104205041	104205041	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr14:104205041C>T	uc001yof.1	-	13	3122	c.2839G>A	c.(2839-2841)Gtg>Atg	p.V947M	PPP1R13B_uc010awv.1_Non-coding_Transcript	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	Homo sapiens protein phosphatase 1, regulatory subunit 13B (PPP1R13B), mRNA.	947					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				GCAGCATTCACGTTGACACCA	0.542000														104			96		0	0	1	0	0
CAP2	10486	broad.mit.edu	37	6	17507412	17507412	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr6:17507412G>A	uc003ncb.3	+	4	556	c.313G>A	c.(313-315)Gca>Aca	p.A105T	CAP2_uc010jpk.1_Non-coding_Transcript|CAP2_uc011dja.2_Missense_Mutation_p.A79T|CAP2_uc011djb.2_Missense_Mutation_p.A105T|CAP2_uc011djc.2_Intron|CAP2_uc011djd.2_Intron	NM_006366	NP_006357	P40123	CAP2_HUMAN	Homo sapiens CAP, adenylate cyclase-associated protein, 2 (yeast) (CAP2), mRNA.	105					activation of adenylate cyclase activity|axon guidance|cytoskeleton organization|establishment or maintenance of cell polarity|signal transduction	plasma membrane	actin binding	p.A105T(2)		breast(3)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(4)|urinary_tract(1)	27	Breast(50;0.0333)|Ovarian(93;0.0386)	all_hematologic(90;0.0466)	all cancers(50;0.194)|Epithelial(50;0.227)			TGACGTGGCCGCACTTCTGAA	0.473000														9			36		0	0	1	0	0
TMEM120A	83862	broad.mit.edu	37	7	75617798	75617798	+	Silent	SNP	G	C	C	rs114564646	by1000genomes	TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr7:75617798G>C	uc003ued.3	-	5	515	c.411C>G	c.(409-411)ctC>ctG	p.L137L	TMEM120A_uc003ueb.1_5'Flank|TMEM120A_uc003uec.2_Silent_p.L42L|TMEM120A_uc022agl.1_Silent_p.L42L	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	Homo sapiens transmembrane protein 120A (TMEM120A), mRNA.	138						integral to membrane											TGGTGAGGTAGAGCTTGAACT	0.647000														45			32		0	0	1	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6898507	6898507	+	Silent	SNP	G	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr18:6898507G>A	uc002knc.3	+	16	5158	c.1947G>A	c.(1945-1947)tcG>tcA	p.S649S	ARHGAP28_uc002kne.3_Intron|ARHGAP28_uc010wzi.2_Intron|ARHGAP28_uc002knf.3_Silent_p.S533S	NM_001010000	NP_001010000	B4DXL2	B4DXL2_HUMAN	Homo sapiens Rho GTPase activating protein 28 (ARHGAP28), mRNA.	0					signal transduction	intracellular				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(2)	37		Colorectal(10;0.168)				GAGAAGAGTCGACAGAGACCA	0.438000														364			7		0	0	1	0	0
TSC22D2	9819	broad.mit.edu	37	3	150127405	150127405	+	Silent	SNP	C	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr3:150127405C>T	uc003exv.3	+	0	618	c.268C>T	c.(268-270)Cta>Tta	p.L90L	TSC22D2_uc003exw.3_Non-coding_Transcript|TSC22D2_uc003exx.3_Silent_p.L90L	NM_014779	NP_055594	O75157	T22D2_HUMAN	Homo sapiens TSC22 domain family, member 2 (TSC22D2), mRNA.	90							sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AAACCTCCTCCTAGATGGGCA	0.662000														6			19		0	0	1	0	0
RIMS1	22999	broad.mit.edu	37	6	73102466	73102466	+	Silent	SNP	A	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr6:73102466A>G	uc003pga.3	+	30	4649	c.4572A>G	c.(4570-4572)ggA>ggG	p.G1524G	RIMS1_uc011dyb.2_Silent_p.G921G|RIMS1_uc003pgc.3_Silent_p.G973G|RIMS1_uc010kaq.3_Silent_p.G844G|RIMS1_uc011dyc.2_Silent_p.G649G|RIMS1_uc010kar.3_Silent_p.G592G|RIMS1_uc011dyd.2_Silent_p.G658G|RIMS1_uc003pge.3_Silent_p.G564G|RIMS1_uc003pgf.3_Silent_p.G524G|RIMS1_uc003pgi.3_Silent_p.G340G|RIMS1_uc003pgg.3_Silent_p.G420G|RIMS1_uc003pgh.3_Silent_p.G391G|RIMS1_uc003pgd.3_Silent_p.G590G|RIMS1_uc011dye.2_Silent_p.G330G|RIMS1_uc011dyf.2_Silent_p.G148G|RIMS1_uc011dyg.2_Silent_p.G51G	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	Homo sapiens regulating synaptic membrane exocytosis 1 (RIMS1), transcript variant 1, mRNA.	1524					calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	Rab GTPase binding|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ATGGATTGGGACCAGCCCAGC	0.403000														59			4		0	0	1	0	0
VANGL1	81839	broad.mit.edu	37	1	116226629	116226630	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr1:116226629_116226630insA	uc001efv.1	+	5	1282_1283	c.1011_1012insA	c.(1009-1014)gactcafs	p.D337fs	VANGL1_uc009wgy.1_Frame_Shift_Ins_p.D335fs|VANGL1_uc021ose.1_Frame_Shift_Ins_p.D337fs	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	Homo sapiens vang-like 1 (van gogh, Drosophila) (VANGL1), transcript variant 1, mRNA.	337					multicellular organismal development	integral to membrane	protein binding	p.D337Y(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(13)|urinary_tract(1)	27	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GGCGCAGGGACTCAAGCCACAA	0.520													---	155	---	---	7	---					
PKLR	5313	broad.mit.edu	37	1	155270047	155270048	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr1:155270047_155270048insC	uc001fkb.4	-	1	163_164	c.124_125insG	c.(124-126)gccfs	p.A42fs	PKLR_uc001fka.4_Frame_Shift_Ins_p.A11fs|PKLR_uc010pga.1_Intron	NM_000298	NP_000289	P30613	KPYR_HUMAN	Homo sapiens pyruvate kinase, liver and RBC (PKLR), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	42					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GGCCACACTGGCCCGCCGCAGA	0.629													---	31	---	---	7	---					
POTEE	445582	broad.mit.edu	37	2	132021077	132021078	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr2:132021077_132021078insA	uc002tsn.2	+	14	2101_2102	c.2049_2050insA	c.(2047-2052)gtgaaafs	p.V683fs	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Frame_Shift_Ins_p.V283fs|POTEE_uc002tsl.2_Frame_Shift_Ins_p.V265fs|POTEE_uc010fmy.1_Frame_Shift_Ins_p.V147fs	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	Homo sapiens POTE ankyrin domain family, member E (POTEE), mRNA.	683							ATP binding										TTGAAAGTGTGAAAAAAAAGAA	0.416													---	769	---	---	7	---					
G3BP2	9908	broad.mit.edu	37	4	76570758	76570758	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr4:76570758delA	uc003hir.3	-	11	1470	c.1305delT	c.(1303-1305)ggtfs	p.G435fs	G3BP2_uc003his.3_Frame_Shift_Del_p.G435fs|G3BP2_uc003hit.3_Frame_Shift_Del_p.G402fs	NM_012297	NP_987101	Q9UN86	G3BP2_HUMAN	Homo sapiens GTPase activating protein (SH3 domain) binding protein 2 (G3BP2), transcript variant 2, mRNA.	435	Gly-rich.				Ras protein signal transduction|cytoplasmic sequestering of NF-kappaB|mRNA transport|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|RNA binding|nucleotide binding|receptor signaling complex scaffold activity	p.P434L(1)		breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	27			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CACGTGGACCACCGGGACCTC	0.522													---	307	---	---	9	---					
AVL9	23080	broad.mit.edu	37	7	32620439	32620439	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr7:32620439delA	uc003tcv.1	+	14	1914	c.1768delA	c.(1768-1770)aaafs	p.K590fs	AVL9_uc011kai.2_Intron|AVL9_uc010kwj.1_Frame_Shift_Del_p.A373fs	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	Homo sapiens AVL9 homolog (S. cerevisiase) (AVL9), mRNA.	590						integral to membrane		p.G589C(1)		endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						TGAACGTGGCAAAAAAATTGG	0.373													---	228	---	---	7	---					
SPDYE1	285955	broad.mit.edu	37	7	44046997	44046997	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr7:44046997delA	uc003tjf.3	+	4	899	c.763delA	c.(763-765)aacfs	p.N255fs	POLR2J4_uc003tjc.2_Intron|POLR2J4_uc003tjd.3_Intron|POLR2J4_uc010kxw.2_Intron|POLR2J4_uc003tje.4_Intron|AX747182_uc003tjg.1_Intron	NM_175064	NP_778234	Q8NFV5	SPDE1_HUMAN	Homo sapiens speedy homolog E1 (Xenopus laevis) (SPDYE1), mRNA.	255	Arg-rich.									endometrium(1)|kidney(4)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	11						CCGTTCCATGAACCCGAGGGC	0.557													---	428	---	---	10	---					
UBR5	51366	broad.mit.edu	37	8	103289349	103289349	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr8:103289349delT	uc003ykr.2	-	44	6815	c.6360delA	c.(6358-6360)aaafs	p.K2120fs	UBR5_uc003yks.2_Frame_Shift_Del_p.K2120fs	NM_015902	NP_056986	O95071	UBR5_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 5 (UBR5), mRNA.	2120					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	RNA binding|protein binding|ubiquitin-ubiquitin ligase activity|zinc ion binding	p.E2121fs*28(2)		NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			CTTCCCCTTCTTTTTTTTGCC	0.378													---	129	---	---	11	---					
DMRTA1	63951	broad.mit.edu	37	9	22451467	22451468	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr9:22451467_22451468insA	uc003zpp.1	+	1	1297_1298	c.1072_1073insA	c.(1072-1074)caafs	p.Q358fs		NM_022160	NP_071443	Q5VZB9	DMRTA_HUMAN	Homo sapiens DMRT-like family A1 (DMRTA1), mRNA.	358					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		GGATGTGGTCCAAGCCATTGAA	0.450													---	163	---	---	8	---					
KIF24	347240	broad.mit.edu	37	9	34257343	34257344	+	Frame_Shift_Ins	INS	-	GGGG	GGGG			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr9:34257343_34257344insGGGG	uc003zua.4	-	10	2381_2382	c.2261_2262insCCCC	c.(2260-2262)ccgfs	p.P754fs	KIF24_uc010mkb.3_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	Homo sapiens kinesin family member 24 (KIF24), mRNA.	754					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			TCTGATGTGGCGGGATGTTTGT	0.540													---	160	---	---	14	---					
COL5A1	1289	broad.mit.edu	37	9	137645718	137645719	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr9:137645718_137645719insG	uc004cfe.3	+	14	2124_2125	c.1742_1743insG	c.(1741-1743)ttgfs	p.L581fs		NM_000093	NP_000084	P20908	CO5A1_HUMAN	Homo sapiens collagen, type V, alpha 1 (COL5A1), mRNA.	581	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGCGGAGGTTTGAAGGGCGAGC	0.658													---	161	---	---	7	---					
MUC5B	727897	broad.mit.edu	37	11	1260210	1260211	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr11:1260210_1260211insC	uc001lta.3	+	25	3466_3467	c.3407_3408insC	c.(3406-3408)tgcfs	p.C1136fs	MUC5B_uc009yct.2_Frame_Shift_Ins_p.C1136fs	NM_002458	NP_002449	Q9HC84	MUC5B_HUMAN	Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.	1136	Cys-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCCAGGCCTGCCACGACGCGG	0.678													---	108	---	---	8	---					
GPR19	2842	broad.mit.edu	37	12	12814274	12814274	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr12:12814274delT	uc001rar.3	-	1	1302	c.1109delA	c.(1108-1110)aacfs	p.N370fs	GPR19_uc001raq.2_Frame_Shift_Del_p.N370fs|GPR19_uc021qvj.1_Frame_Shift_Del_p.N370fs	NM_006143	NP_006134	Q15760	GPR19_HUMAN	Homo sapiens G protein-coupled receptor 19 (GPR19), mRNA.	370						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.048)		GCCAACGTAGTTTTTTTTGGC	0.398													---	310	---	---	7	---					
C12orf51	283450	broad.mit.edu	37	12	112688161	112688162	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr12:112688161_112688162insC	uc021reb.1	-	24	3730_3731	c.3334_3335insG	c.(3334-3336)gccfs	p.A1112fs	C12orf51_uc010syk.1_Frame_Shift_Ins_p.A646fs|C12orf51_uc001tts.2_Frame_Shift_Ins_p.A637fs|C12orf51_uc001ttt.3_Frame_Shift_Ins_p.A635fs	NM_001109662	NP_001103132			Homo sapiens chromosome 12 open reading frame 51 (C12orf51), mRNA.											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(6)|large_intestine(16)|lung(49)|ovary(4)|prostate(1)|urinary_tract(6)	100						CACGCCATTGGCCTCCACCTGC	0.525													---	80	---	---	7	---					
POTEG	404785	broad.mit.edu	37	14	19553498	19553499	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr14:19553498_19553499insG	uc001vuz.1	+	0	134_135	c.82_83insG	c.(82-84)tgcfs	p.C28fs	POTEG_uc001vva.1_Non-coding_Transcript|POTEG_uc010ahc.1_Non-coding_Transcript	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	Homo sapiens POTE ankyrin domain family, member G (POTEG), transcript variant 1, mRNA.	28										cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GGGCAAGTGGTGCCGCCACTGC	0.574													---	892	---	---	15	---					
DPPA3	359787	broad.mit.edu	37	14	36841072	36841073	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr14:36841072_36841073insA	uc001wtp.3	+	0	703_704	c.454_455insA	c.(454-456)caafs	p.Q152fs		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	Homo sapiens developmental pluripotency associated 3 (DPPA3), mRNA.	152						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		AATAGAGAATCAAGACACCAAG	0.391													---	774	---	---	23	---					
YLPM1	56252	broad.mit.edu	37	14	75248591	75248592	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr14:75248591_75248592insC	uc001xqj.4	+	3	1969_1970	c.1845_1846insC	c.(1843-1848)cctccafs	p.P615fs	YLPM1_uc001xql.4_Non-coding_Transcript	NM_019589	NP_062535	P49750	YLPM1_HUMAN	Homo sapiens YLP motif containing 1 (YLPM1), mRNA.	420					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CAACAGCACCTCCACCTGTCAT	0.579													---	232	---	---	7	---					
abParts	0	broad.mit.edu	37	14	106791294	106791294	+	RNA	DEL	A	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr14:106791294delA	uc021ser.1	-	619		c.17098delT								Parts of antibodies, mostly variable regions.																		CACCAGCTGCACCTGACACTG	0.532													---	630	---	---	12	---					
PLA2G4D	283748	broad.mit.edu	37	15	42362217	42362218	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr15:42362217_42362218insG	uc001zox.3	-	18	2214_2215	c.2119_2120insC	c.(2119-2121)cagfs	p.Q707fs		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	Homo sapiens phospholipase A2, group IVD (cytosolic) (PLA2G4D), mRNA.	707	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		TGGCTGGTGCTGGTCCTGAGGG	0.688													---	146	---	---	7	---					
C15orf48	84419	broad.mit.edu	37	15	45723237	45723238	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr15:45723237_45723238insG	uc001zvg.3	+	2	193_194	c.75_76insG	c.(73-78)ggtggafs	p.G25fs	C15orf48_uc001zvh.3_Frame_Shift_Ins_p.G25fs|C15orf48_uc021skp.1_5'Flank	NM_197955	NP_922946	Q9C002	NMES1_HUMAN	Homo sapiens chromosome 15 open reading frame 48 (C15orf48), transcript variant 1, mRNA.	25						nucleus		p.A24A(1)|p.G25D(1)		large_intestine(1)|lung(2)|ovary(1)	4		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		TGGCGGCGGGTGGAGCCTCATC	0.416													---	273	---	---	10	---					
LOC648809	648809	broad.mit.edu	37	15	84790358	84790359	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr15:84790358_84790359insC	uc021stg.1	+	8	964_965	c.480_481insC	c.(478-483)gctcgafs	p.A160fs						Homo sapiens elongation factor Tu GTP-binding domain-containing protein 1 pseudogene (LOC648809), non-coding RNA.																		GTGGTGTGGCTCGAAGAGGAAA	0.411													---	163	---	---	10	---					
ZSCAN10	84891	broad.mit.edu	37	16	3140487	3140488	+	Frame_Shift_Ins	INS	-	C	C	rs140902087		TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr16:3140487_3140488insC	uc002ctv.1	-	4	870_871	c.782_783insG	c.(781-783)ggcfs	p.G261fs	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Frame_Shift_Ins_p.G179fs|ZSCAN10_uc002ctx.1_Frame_Shift_Ins_p.G189fs	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	Homo sapiens zinc finger and SCAN domain containing 10 (ZSCAN10), mRNA.	261					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						CTTCACCAGGGCCGCTAGCCGC	0.639													---	94	---	---	8	---					
CCDC144A	9720	broad.mit.edu	37	17	16665752	16665753	+	Frame_Shift_Ins	INS	-	A	A			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr17:16665752_16665753insA	uc002gqk.1	+	13	3868_3869	c.3792_3793insA	c.(3790-3795)tcgcaafs	p.S1264fs	CCDC144A_uc002gql.1_Frame_Shift_Ins_p.S780fs|CCDC144A_uc010cpj.1_Non-coding_Transcript	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	Homo sapiens coiled-coil domain containing 144A (CCDC144A), mRNA.	1264																	TAAAAACTTCGCAAGCCGACTT	0.347													---	186	---	---	11	---					
TTLL6	284076	broad.mit.edu	37	17	46847199	46847202	+	Frame_Shift_Del	DEL	CATG	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr17:46847199_46847202delCATG	uc021tzm.1	-	13	2333_2336	c.2298_2301delCATG	c.(2296-2301)gacatgfs	p.D766fs	TTLL6_uc002iob.3_Frame_Shift_Del_p.D459fs|TTLL6_uc010dbi.3_Intron|TTLL6_uc002ioc.3_Frame_Shift_Del_p.D519fs|TTLL6_uc002iod.3_Intron	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	Homo sapiens tubulin tyrosine ligase-like family, member 6 (TTLL6), transcript variant 1, mRNA.	718						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GTGGCTTGTTCATGTCACTCTTTA	0.451													---	163	---	---	7	---					
LAMA1	284217	broad.mit.edu	37	18	6949154	6949155	+	Frame_Shift_Ins	INS	-	C	C	rs35759306		TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr18:6949154_6949155insC	uc002knm.3	-	58	8595_8596	c.8501_8502insG	c.(8500-8502)ggtfs	p.G2834fs	LAMA1_uc002knk.3_Frame_Shift_Ins_p.G164fs|LAMA1_uc002knl.3_Frame_Shift_Ins_p.G287fs|LAMA1_uc010wzj.2_Frame_Shift_Ins_p.G2310fs	NM_005559	NP_005550	P25391	LAMA1_HUMAN	Homo sapiens laminin, alpha 1 (LAMA1), mRNA.	2834	Laminin G-like 4.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGTAGAACAAACCCTCCACATC	0.480													---	124	---	---	7	---					
ADAMTS10	81794	broad.mit.edu	37	19	8650351	8650352	+	Frame_Shift_Ins	INS	-	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr19:8650351_8650352insT	uc002mkj.1	-	22	3127_3128	c.2853_2854insA	c.(2851-2856)ctcgacfs	p.L951fs	ADAMTS10_uc002mki.1_Frame_Shift_Ins_p.L438fs|ADAMTS10_uc002mkk.1_Frame_Shift_Ins_p.L583fs	NM_030957	NP_112219	Q9H324	ATS10_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 10 (ADAMTS10), mRNA.	951	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						TCAGACCAGTCGAGGGCCGCCC	0.713													---	4	---	---	2	---					
MAP1S	55201	broad.mit.edu	37	19	17838792	17838793	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr19:17838792_17838793insC	uc002nhe.1	+	4	2608_2609	c.2599_2600insC	c.(2599-2601)gccfs	p.A867fs	MAP1S_uc010eaz.2_Frame_Shift_Ins_p.A480fs|MAP1S_uc010xpv.1_Frame_Shift_Ins_p.A841fs	NM_018174	NP_060644	Q66K74	MAP1S_HUMAN	Homo sapiens microtubule-associated protein 1S (MAP1S), mRNA.	867	Necessary for association with microtubules.|Necessary for interaction with RASSF1 isoform A and isoform C.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	DNA binding|actin filament binding|beta-tubulin binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						GAAGCCCCTGGCCCGCCCCAAC	0.668													---	73	---	---	7	---					
FUZ	80199	broad.mit.edu	37	19	50312460	50312461	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr19:50312460_50312461insG	uc002ppq.2	-	6	949_950	c.745_746insC	c.(745-747)ctcfs	p.L249fs	FUZ_uc002ppt.2_Non-coding_Transcript|FUZ_uc002ppu.2_Frame_Shift_Ins_p.L213fs	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	Homo sapiens fuzzy homolog (Drosophila) (FUZ), transcript variant 1, mRNA.	249	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		CGGCCCGCAGAGTAGACACAGC	0.673													---	126	---	---	7	---					
NLRP13	126204	broad.mit.edu	37	19	56424477	56424477	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr19:56424477delT	uc010ygg.2	-	4	731	c.706delA	c.(706-708)aggfs	p.R236fs		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	Homo sapiens NLR family, pyrin domain containing 13 (NLRP13), mRNA.	236	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ACCCCTGCCCTCCCCACCAAG	0.502													---	153	---	---	7	---					
SIGLEC1	6614	broad.mit.edu	37	20	3677991	3677992	+	Splice_Site	INS	-	G	G			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr20:3677991_3677992insG	uc002wja.3	-	9	2123	c.2123_splice	c.e9-1	p.A708_splice	SIGLEC1_uc002wiz.4_Splice_Site_p.A708_splice	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	Homo sapiens sialic acid binding Ig-like lectin 1, sialoadhesin (SIGLEC1), mRNA.	708	Ig-like C2-type 7.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGACAGTGGCTGGAGAGCAGGC	0.658													---	159	---	---	7	---					
POTEH	23784	broad.mit.edu	37	22	16266972	16266973	+	Frame_Shift_Ins	INS	-	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr22:16266972_16266973insT	uc010gqp.2	-	8	1528_1529	c.1476_1477insA	c.(1474-1479)cctgaafs	p.P492fs	POTEH_uc002zlg.1_Non-coding_Transcript|POTEH_uc002zlh.1_Frame_Shift_Ins_p.P211fs|POTEH_uc002zlj.1_Frame_Shift_Ins_p.P327fs	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	Homo sapiens POTE ankyrin domain family, member H (POTEH), mRNA.	492										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TGCTGGCTTTCAGGTGTTCTGC	0.431													---	1912	---	---	7	---					
RIMBP3	85376	broad.mit.edu	37	22	20458634	20458635	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chr22:20458634_20458635insC	uc002zsd.4	-	0	3152_3153	c.2667_2668insG	c.(2665-2670)gtgcccfs	p.V889fs	RN7SK_uc021wlw.1_5'Flank	NM_015672	NP_056487			Homo sapiens RIMS binding protein 3 (RIMBP3), mRNA.											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AAGTTGGAGGGCACCAGCCCCC	0.609													---	474	---	---	8	---					
SATL1	340562	broad.mit.edu	37	X	84363631	84363632	+	Frame_Shift_Ins	INS	-	T	T			TCGA-KO-8409-01A-11D-2310-10	TCGA-KO-8409-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8df1eeb4-dfc9-4a0a-8f93-98460c3ab489	ab217c1c-6141-4391-85a8-cacd3c7b1989	g.chrX:84363631_84363632insT	uc004een.3	-	0	343_344	c.343_344insA	c.(343-345)agcfs	p.S115fs		NM_001012980	NP_001012998	Q86VE3	SATL1_HUMAN	Homo sapiens spermidine/spermine N1-acetyl transferase-like 1 (SATL1), mRNA.	170	Gln-rich.						N-acetyltransferase activity			NS(1)|breast(5)|endometrium(2)|large_intestine(3)|lung(13)|skin(3)|stomach(1)|urinary_tract(1)	29						GCCTGATTGGCTTGGGCCTGGT	0.545											OREG0019887	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	---	253	---	---	8	---					
