Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
XPO4	64328	broad.mit.edu	37	13	21373326	21373326	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr13:21373326G>A	uc001unq.4	-	15	2336	c.2300C>T	c.(2299-2301)aCc>aTc	p.T767I		NM_022459	NP_071904	Q9C0E2	XPO4_HUMAN	Homo sapiens exportin 4 (XPO4), mRNA.	767					protein transport	cytoplasm|nucleus	protein binding			breast(1)|endometrium(10)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	41		all_cancers(29;5.05e-24)|all_epithelial(30;5.56e-20)|all_lung(29;2.38e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000521)|Epithelial(112;0.000892)|OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Lung(94;0.0189)|LUSC - Lung squamous cell carcinoma(192;0.0548)		CTGCTGTTTGGTTTCTGTGTC	0.443000														147			4		0	0	1	0	0
RILPL1	353116	broad.mit.edu	37	12	123957223	123957223	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr12:123957223G>T	uc001ufe.2	-	6	1310	c.1074C>A	c.(1072-1074)agC>agA	p.S358R	RILPL1_uc001ufd.2_Missense_Mutation_p.S207R|RILPL1_uc010tas.1_3'UTR	NM_178314	NP_847884	Q5EBL4	RIPL1_HUMAN	Homo sapiens Rab interacting lysosomal protein-like 1 (RILPL1), mRNA.	358					neuroprotection	cytosol		p.S358R(6)		endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000224)|Epithelial(86;0.00067)|all cancers(50;0.00836)|BRCA - Breast invasive adenocarcinoma(302;0.197)		GGGAGAAGAAGCTAAACCTTT	0.498000														84			8		3.09899e-07	3.09899e-07	1	1	0
FAT1	2195	broad.mit.edu	37	4	187541479	187541479	+	Silent	SNP	G	A	A			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr4:187541479G>A	uc003izf.3	-	9	6449	c.6261C>T	c.(6259-6261)taC>taT	p.Y2087Y		NM_005245	NP_005236	Q14517	FAT1_HUMAN	Homo sapiens FAT tumor suppressor homolog 1 (Drosophila) (FAT1), mRNA.	2087	Cadherin 19.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TAACAACGGCGTAGTAGGGAA	0.498000										HNSCC(5;0.00058)				132			4		0	0	1	0	0
WNT2B	7482	broad.mit.edu	37	1	113058941	113058941	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr1:113058941G>A	uc001ecb.3	+	2	1098	c.583G>A	c.(583-585)Ggt>Agt	p.G195S	WNT2B_uc001eca.3_Missense_Mutation_p.G176S|WNT2B_uc009wgg.3_Missense_Mutation_p.G103S	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	Homo sapiens wingless-type MMTV integration site family, member 2B (WNT2B), transcript variant WNT-2B2, mRNA.	195					Wnt receptor signaling pathway, calcium modulating pathway|chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATCCACTACGGTGTCCGTTT	0.572000														73			6		0	0	1	0	0
FAM75E1	286234	broad.mit.edu	37	9	90500482	90500482	+	Silent	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr9:90500482C>T	uc004app.4	+	3	1115	c.1080C>T	c.(1078-1080)gaC>gaT	p.D360D	FAM75E1_uc004apo.1_Silent_p.D172D	NM_178828	NP_849150	Q6ZUB1	CI079_HUMAN	Homo sapiens chromosome 9 open reading frame 79 (C9orf79), mRNA.	360						integral to membrane											TCCACCCTGACGTGCAGAAGC	0.577000														51			6		0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28216883	28216883	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr21:28216883C>T	uc002ymf.3	-	0	846	c.391G>A	c.(391-393)Ggc>Agc	p.G131S		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 1 (ADAMTS1), mRNA.	131					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		CTGGGATCGCCATTCACGGTG	0.697000											OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		38			9		0	0	1	0	0
MARCH9	92979	broad.mit.edu	37	12	58152575	58152575	+	Silent	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr12:58152575C>T	uc001spx.2	+	3	1367	c.936C>T	c.(934-936)cgC>cgT	p.R312R	MARCH9_uc001spy.3_Silent_p.R199R	NM_138396	NP_612405	Q86YJ5	MARH9_HUMAN	Homo sapiens membrane-associated ring finger (C3HC4) 9 (MARCH9), mRNA.	312						Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding			autonomic_ganglia(1)|large_intestine(2)|lung(1)	4	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TGCCTCAGCGCTGCGGTTATA	0.657000														46			34		0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116616283	116616283	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr8:116616283T>C	uc003yny.3	-	3	2491	c.1913A>G	c.(1912-1914)gAc>gGc	p.D638G	TRPS1_uc011lhy.2_Missense_Mutation_p.D629G|TRPS1_uc003ynz.3_Missense_Mutation_p.D625G|TRPS1_uc010mcy.3_Missense_Mutation_p.D625G	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	Homo sapiens trichorhinophalangeal syndrome I (TRPS1), mRNA.	625	Mediates interaction with GLI3.				NLS-bearing substrate import into nucleus|negative regulation of transcription from RNA polymerase II promoter|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TACATCTACGTCAGGGGTGGT	0.517000									Langer-Giedion syndrome					104			4		0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23522739	23522739	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr14:23522739C>T	uc001wil.3	-	6	1452	c.1192G>A	c.(1192-1194)Gcg>Acg	p.A398T	CDH24_uc010akf.3_Missense_Mutation_p.A398T|CDH24_uc001win.3_Missense_Mutation_p.A398T	NM_022478	NP_071923	Q86UP0	CAD24_HUMAN	Homo sapiens cadherin 24, type 2 (CDH24), transcript variant 1, mRNA.	398	Cadherin 4.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		AGGTCAGCCGCGGAGATCTGG	0.632000														113			4		0	0	1	0	0
ZNF836	162962	broad.mit.edu	37	19	52660555	52660555	+	Silent	SNP	A	G	G			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr19:52660555A>G	uc010ydj.2	-	4	903	c.381T>C	c.(379-381)caT>caC	p.H127H	ZNF836_uc010ydi.2_Silent_p.H127H	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	Homo sapiens zinc finger protein 836 (ZNF836), mRNA.	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						CCTCTTGACTATGTTGACCTC	0.333000														108			72		0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65960371	65960371	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr17:65960371C>T	uc002jgf.3	+	24	8366	c.8305C>T	c.(8305-8307)Cgc>Tgc	p.R2769C	BPTF_uc002jge.3_Missense_Mutation_p.R2752C|BPTF_uc021uca.1_Missense_Mutation_p.R569C|BPTF_uc002jgg.3_Missense_Mutation_p.R484C|BPTF_uc002jgh.3_Missense_Mutation_p.R286C	NM_182641	NP_872579	Q12830	BPTF_HUMAN	Homo sapiens bromodomain PHD finger transcription factor (BPTF), transcript variant 1, mRNA.	2895					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex|cytoplasm	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			GTACCATGGGCGCTGCGTTGG	0.463000														45			9		0	0	1	0	0
DSPP	1834	broad.mit.edu	37	4	88535571	88535571	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr4:88535571A>G	uc003hqu.3	+	4	1877	c.1757A>G	c.(1756-1758)gAc>gGc	p.D586G		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	Homo sapiens dentin sialophosphoprotein (DSPP), mRNA.	586	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		agtgacagtgacagcagtgat	0.458000														272			8		0	0	1	0	0
MYBPC3	4607	broad.mit.edu	37	11	47356593	47356593	+	Splice_Site	SNP	G	A	A			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr11:47356593G>A	uc021qis.1	-	27	2960	c.2905_splice	c.e27+1	p.Q969_splice	MYBPC3_uc021qir.1_Splice_Site_p.Q621_splice	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	Homo sapiens myosin binding protein C, cardiac (MYBPC3), mRNA.	968					cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	ATPase activator activity|actin binding|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		GGGCACTCACGCAGGATCTCC	0.642000														65			14		0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81675147	81675147	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr12:81675147A>G	uc001szo.2	-	26	3262	c.3101T>C	c.(3100-3102)tTa>tCa	p.L1034S	PPFIA2_uc010sug.2_Non-coding_Transcript|PPFIA2_uc021rbg.1_Missense_Mutation_p.L933S|PPFIA2_uc021rbh.1_Missense_Mutation_p.L929S|PPFIA2_uc021rbi.1_Missense_Mutation_p.L1028S|PPFIA2_uc021rbj.1_Missense_Mutation_p.L1013S|PPFIA2_uc021rbk.1_Missense_Mutation_p.L1019S|PPFIA2_uc021rbl.1_Missense_Mutation_p.L1034S|PPFIA2_uc010sue.2_Intron|PPFIA2_uc021rbe.1_Missense_Mutation_p.L570S|PPFIA2_uc021rbf.1_Missense_Mutation_p.L220S	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (PPFIA2), transcript variant 1, mRNA.	933										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						GTACTGAGGTAACCCCAAGCT	0.393000														129			4		0	0	1	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	C	C	rs72555397		TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr6:29910607G>C	uc003nol.3	+	1	231	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-G_uc021ytw.1_Intron|HLA-G_uc011dmb.2_Intron|HLA-J_uc021yty.1_Intron|AK097625_uc003nog.1_Intron|HLA-A_uc021ytz.1_Silent_p.V49V|HLA-A_uc010jrq.3_5'UTR|HLA-A_uc003nok.3_5'UTR|HLA-A_uc021yua.1_Missense_Mutation_p.G93R|HLA-A_uc010klp.2_Silent_p.V21V|HLA-A_uc011dmc.2_5'UTR|HLA-A_uc011dmd.2_5'Flank|HLA-A_uc021yub.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	Homo sapiens major histocompatibility complex, class I, A (HLA-A), transcript variant 1, mRNA.	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to plasma membrane	MHC class I receptor activity	p.V49V(4)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)				41			10		0	0	1	0	0
FAM179A	165186	broad.mit.edu	37	2	29274925	29274925	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr2:29274925C>T	uc010ezl.3	+	19	3377	c.3026C>T	c.(3025-3027)aCa>aTa	p.T1009I	FAM179A_uc010ymm.2_Missense_Mutation_p.T954I|FAM179A_uc002rmr.4_Missense_Mutation_p.T536I	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	Homo sapiens family with sequence similarity 179, member A (FAM179A), mRNA.	1009							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GACAGCAAGACAACTGGCAGC	0.478000														39			9		0	0	1	0	0
PDP1	54704	broad.mit.edu	37	8	94934838	94934838	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr8:94934838G>A	uc011lgn.2	+	1	777	c.728G>A	c.(727-729)cGg>cAg	p.R243Q	PDP1_uc003ygf.3_Missense_Mutation_p.R209Q|PDP1_uc003yge.3_Missense_Mutation_p.R184Q|PDP1_uc010max.3_Missense_Mutation_p.R209Q|PDP1_uc011lgm.2_Missense_Mutation_p.R184Q|PDP1_uc022ayg.1_Missense_Mutation_p.R184Q	NM_001161778	NP_001155250	Q9P0J1	PDP1_HUMAN	Homo sapiens pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	184					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						GAGAGCGGCCGGGCACTGCTA	0.453000														40			4		0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47968829	47968829	+	Silent	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr7:47968829C>T	uc003tny.2	-	6	1066	c.1032G>A	c.(1030-1032)gcG>gcA	p.A344A		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	Homo sapiens polycystic kidney disease 1 like 1 (PKD1L1), mRNA.	344					cell-cell adhesion	integral to membrane		p.A344V(1)	BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AGGCAGTCACCGCCATTGCCT	0.527000														137			16		0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23728528	23728528	+	Silent	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr20:23728528C>T	uc002wtp.3	-	2	422	c.351G>A	c.(349-351)ttG>ttA	p.L117L		NM_001898	NP_001889	P01037	CYTN_HUMAN	Homo sapiens cystatin SN (CST1), mRNA.	117						extracellular region	cysteine-type endopeptidase inhibitor activity	p.L117L(2)		kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					CGAAAGAGCACAACTGTTTCT	0.527000														125			4		0	0	1	0	0
NEURL	9148	broad.mit.edu	37	10	105331354	105331354	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr10:105331354G>A	uc001kxh.3	+	2	834	c.424G>A	c.(424-426)Gcc>Acc	p.A142T	NEURL_uc021pxn.1_Missense_Mutation_p.A125T	NM_004210	NP_004201	O76050	NEU1A_HUMAN	Homo sapiens neuralized homolog (Drosophila) (NEURL), mRNA.	142	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GCCCAAGTACGCCTGCCCCGA	0.632000														51			3		0	0	1	0	0
C14orf135	64430	broad.mit.edu	37	14	60581861	60581861	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr14:60581861C>T	uc001xer.4	+	2	859	c.337C>T	c.(337-339)Ccg>Tcg	p.P113S	C14orf135_uc001xeq.2_Missense_Mutation_p.P113S	NM_022495	NP_071940	Q63HM2	CN135_HUMAN	Homo sapiens chromosome 14 open reading frame 135 (C14orf135), mRNA.	347						integral to membrane				endometrium(3)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	18		Myeloproliferative disorder(585;0.163)		OV - Ovarian serous cystadenocarcinoma(108;0.127)		ACCCAGTGGTCCGGAAAAACA	0.383000														184			4		0	0	1	0	0
EXOC5	10640	broad.mit.edu	37	14	57675499	57675499	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr14:57675499T>C	uc001xct.3	-	17	2206	c.1955A>G	c.(1954-1956)cAt>cGt	p.H652R	EXOC5_uc001xcs.3_Missense_Mutation_p.H331R|EXOC5_uc010trg.2_Missense_Mutation_p.H597R|EXOC5_uc010trh.2_Missense_Mutation_p.H587R	NM_006544	NP_006535	O00471	EXOC5_HUMAN	Homo sapiens exocyst complex component 5 (EXOC5), mRNA.	652					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				breast(3)|endometrium(1)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	22						ATCAAAAAGATGTAATACCAT	0.343000														76			71		0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185891568	185891568	+	Nonsense_Mutation	SNP	C	T	T			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr1:185891568C>T	uc001grq.1	+	6	1187	c.958C>T	c.(958-960)Cga>Tga	p.R320*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	Homo sapiens hemicentin 1 (HMCN1), mRNA.	320					response to stimulus|visual perception	basement membrane	calcium ion binding	p.R320*(2)|p.F319L(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TATTGATTTCCGAGCTGGCTT	0.423000														89			4		0	0	1	0	0
GGH	8836	broad.mit.edu	37	8	63942762	63942762	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr8:63942762T>C	uc003xuw.3	-	2	522	c.239A>G	c.(238-240)gAg>gGg	p.E80G		NM_003878	NP_003869	Q92820	GGH_HUMAN	Homo sapiens gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (GGH), mRNA.	80	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	ATAGTCTTTCTCTGTAAGATC	0.318000														60			4		0	0	1	0	0
NKTR	4820	broad.mit.edu	37	3	42660605	42660605	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr3:42660605G>A	uc003clo.3	+	3	374	c.227G>A	c.(226-228)gGg>gAg	p.G76E	NKTR_uc003cll.1_Missense_Mutation_p.G76E|NKTR_uc003clm.1_5'UTR|NKTR_uc011azp.2_5'UTR|NKTR_uc003clp.3_5'UTR|NKTR_uc003clq.1_5'Flank	NM_005385	NP_005376	P30414	NKTR_HUMAN	Homo sapiens natural killer-tumor recognition sequence (NKTR), mRNA.	76	PPIase cyclophilin-type.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		ATTCAGGGTGGGGACTTCAGT	0.353000														114			4		0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49689196	49689196	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr3:49689196delA	uc003cxe.4	+	4	2321	c.2207delA	c.(2206-2208)cagfs	p.Q736fs		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	Homo sapiens bassoon (presynaptic cytomatrix protein) (BSN), mRNA.	736					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CCTTTGCTGCAGGCCCAGGGC	0.662													---	103	---	---	7	---					
RAD54L2	23132	broad.mit.edu	37	3	51624506	51624508	+	In_Frame_Del	DEL	GAG	-	-			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr3:51624506_51624508delGAG	uc011bdt.2	+	1	195_197	c.70_72delGAG	c.(70-72)gagdel	p.E30del	RAD54L2_uc003dbh.3_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	Homo sapiens RAD54-like 2 (S. cerevisiae) (RAD54L2), mRNA.	30						nucleus	ATP binding|DNA binding|helicase activity	p.E30V(1)		NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		ggatgcggaagaggaggaggagg	0.586													---	103	---	---	7	---					
POM121	9883	broad.mit.edu	37	7	72413476	72413477	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr7:72413476_72413477insC	uc003twk.2	+	10	2944_2945	c.2944_2945insC	c.(2944-2946)gccfs	p.A982fs	POM121_uc003twj.3_Frame_Shift_Ins_p.A717fs|POM121_uc010lam.1_Frame_Shift_Ins_p.A717fs	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	Homo sapiens POM121 membrane glycoprotein (POM121), mRNA.	982	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore		p.R982H(1)		NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				GCCACCGGGGGCCGCCAAGCCG	0.653													---	201	---	---	9	---					
EPS8	2059	broad.mit.edu	37	12	15784389	15784392	+	Frame_Shift_Del	DEL	TTGT	-	-			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr12:15784389_15784392delTTGT	uc009zif.3	-	17	2122_2125	c.2028_2031delACAA	c.(2026-2031)aaacaafs	p.K676fs	EPS8_uc001rdb.3_Frame_Shift_Del_p.K676fs|EPS8_uc009zig.3_Frame_Shift_Del_p.K416fs|EPS8_uc010shv.2_Frame_Shift_Del_p.K416fs	NM_004447	NP_004438	Q12929	EPS8_HUMAN	Homo sapiens epidermal growth factor receptor pathway substrate 8 (EPS8), mRNA.	676					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		CCACCGGAAGTTGTTTGTGTCTCT	0.441													---	82	---	---	32	---					
SLC4A8	9498	broad.mit.edu	37	12	51868965	51868966	+	Frame_Shift_Ins	INS	-	G	G			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr12:51868965_51868966insG	uc001rys.1	+	15	2325_2326	c.2147_2148insG	c.(2146-2148)aagfs	p.K716fs	SLC4A8_uc001rym.3_Frame_Shift_Ins_p.K663fs|SLC4A8_uc001ryn.3_Frame_Shift_Ins_p.K663fs|SLC4A8_uc001ryo.2_Frame_Shift_Ins_p.K663fs|SLC4A8_uc010snj.2_Frame_Shift_Ins_p.K743fs|SLC4A8_uc001ryr.3_Frame_Shift_Ins_p.K716fs|SLC4A8_uc010snk.2_Frame_Shift_Ins_p.K663fs	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	Homo sapiens solute carrier family 4, sodium bicarbonate cotransporter, member 8 (SLC4A8), transcript variant 1, mRNA.	716					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		AAGACGTTTAAGACGAGCCGTT	0.446													---	252	---	---	7	---					
CFDP1	10428	broad.mit.edu	37	16	75448501	75448501	+	Frame_Shift_Del	DEL	T	-	-			TCGA-KO-8411-01A-11D-2310-10	TCGA-KO-8411-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9dfcbabf-2bc0-43a2-bdde-d0b2aaca3f6b	7f8f088d-0cab-4301-8a5d-9e780d18439b	g.chr16:75448501delT	uc002fdy.3	-	1	294	c.157delA	c.(157-159)agafs	p.R53fs	CFDP1_uc002fdz.3_5'UTR|CFDP1_uc002fea.1_Frame_Shift_Del_p.R53fs	NM_006324	NP_006315	Q9UEE9	CFDP1_HUMAN	Homo sapiens craniofacial development protein 1 (CFDP1), mRNA.	53	Glu-rich.				multicellular organismal development					endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5						TGGGCCTTTCTTTTTTTCCCT	0.443													---	259	---	---	7	---					
