Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAP9	79884	broad.mit.edu	37	4	156294336	156294336	+	Missense_Mutation	SNP	T	C	C			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr4:156294336T>C	uc003ios.3	-	3	697	c.433A>G	c.(433-435)Aaa>Gaa	p.K145E	MAP9_uc011cin.2_Missense_Mutation_p.K145E|MAP9_uc010iqa.1_Non-coding_Transcript|MAP9_uc003iot.1_Missense_Mutation_p.K145E|MAP9_uc010iqb.2_Missense_Mutation_p.K73E	NM_001039580	NP_001034669	Q49MG5	MAP9_HUMAN	Homo sapiens microtubule-associated protein 9 (MAP9), mRNA.	145					cell division|mitosis	cytoplasm|microtubule|spindle				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.143)		GGTTTCATTTTTATTTTGTCT	0.303000														57			13		0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53057816	53057816	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr19:53057816G>T	uc010epq.1	+	4	1824	c.1647G>T	c.(1645-1647)atG>atT	p.M549I	ZNF808_uc002pzq.2_Non-coding_Transcript|ZNF808_uc010epr.2_5'Flank	NM_001039886	NP_001034975	Q8N4W9	ZN808_HUMAN	Homo sapiens zinc finger protein 808 (ZNF808), mRNA.	549					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		AGGTTTTCATGCGTAATTCAG	0.398000														31			12		3.52763e-06	3.52763e-06	1	1	0
HCN1	348980	broad.mit.edu	37	5	45267264	45267264	+	Silent	SNP	G	A	A	rs141455774	byFrequency	TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr5:45267264G>A	uc003jok.3	-	6	1735	c.1710C>T	c.(1708-1710)aaC>aaT	p.N570N		NM_021072	NP_066550	O60741	HCN1_HUMAN	Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (HCN1), mRNA.	570						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.N570Y(2)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CCAGGACCTCGTTGAAATTGT	0.428000														23			34		0	0	1	0	0
AX747192	0	broad.mit.edu	37	11	63998305	63998305	+	Silent	SNP	T	C	C			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr11:63998305T>C	uc001nyr.1	-	0	456	c.24A>G	c.(22-24)ggA>ggG	p.G8G	DNAJC4_uc001nys.3_5'UTR|DNAJC4_uc001nyt.3_5'UTR|DNAJC4_uc001nyu.3_5'UTR					Homo sapiens cDNA FLJ34477 fis, clone HLUNG2003833.																		TAGCCTCCTTTCCCAGCTGCC	0.701000														61			6		0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100832274	100832274	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr8:100832274A>G	uc003yiv.3	+	48	9104	c.8993A>G	c.(8992-8994)gAc>gGc	p.D2998G	VPS13B_uc003yiw.3_Missense_Mutation_p.D2973G	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	Homo sapiens vacuolar protein sorting 13 homolog B (yeast) (VPS13B), transcript variant 5, mRNA.	2998					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCCAAATGGGACCTCTGGCTA	0.393000														101			4		0	0	1	0	0
FAM163A	148753	broad.mit.edu	37	1	179782953	179782953	+	Missense_Mutation	SNP	G	A	A			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr1:179782953G>A	uc009wxj.3	+	5	592	c.133G>A	c.(133-135)Gag>Aag	p.E45K	FAM163A_uc001gnj.3_Missense_Mutation_p.E45K|FAM163A_uc009wxk.3_Missense_Mutation_p.E45K	NM_173509	NP_775780	Q96GL9	F163A_HUMAN	Homo sapiens family with sequence similarity 163, member A (FAM163A), mRNA.	45						integral to membrane				endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(1)	15						GGTTGCAGACGAGGAGGAGGA	0.642000														92			4		0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	118017	118017	+	RNA	SNP	G	A	A			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chrGL000205.1:118017G>A	uc002kgk.4	+	0		c.1395G>A								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		GGCAGAATACGAGGGGCAGCC	0.562000														35			5		0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12735002	12735002	+	Silent	SNP	C	T	T			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chrX:12735002C>T	uc004cuz.2	+	14	2930	c.2424C>T	c.(2422-2424)gcC>gcT	p.A808A	FRMPD4_uc011mij.2_Silent_p.A800A	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	Homo sapiens FERM and PDZ domain containing 4 (FRMPD4), mRNA.	808					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						TGGCCATTGCCGCACCCCCAC	0.547000														75			4		0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18849726	18849726	+	Missense_Mutation	SNP	G	T	T			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr16:18849726G>T	uc002dfm.3	-	43	7510	c.7147C>A	c.(7147-7149)Ctg>Atg	p.L2383M	SMG1_uc010bwb.3_Missense_Mutation_p.L2243M|SMG1_uc010bwa.3_Missense_Mutation_p.L1114M	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	Homo sapiens smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) (SMG1), mRNA.	2383	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						GTTACACCCAGTGCTGTTTCA	0.373000														140			31		1.04594e-18	1.10405e-18	1	1	0
UBR5	51366	broad.mit.edu	37	8	103324629	103324629	+	Missense_Mutation	SNP	C	G	G			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr8:103324629C>G	uc003ykr.2	-	16	2547	c.2092G>C	c.(2092-2094)Gat>Cat	p.D698H	UBR5_uc003yks.2_Missense_Mutation_p.D698H	NM_015902	NP_056986	O95071	UBR5_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 5 (UBR5), mRNA.	698					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	RNA binding|protein binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GGGTCAGCATCTGGACCAGAG	0.408000														113			9		0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	A	A			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr17:7578212G>A	uc002gim.2	-	5	831	c.637C>T	c.(637-639)Cga>Tga	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.3_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.2_Nonsense_Mutation_p.R174*|DL476358_uc021tph.1_5'Flank	NM_001126112	NP_001119587	P04637	P53_HUMAN	Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA.	213	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).		DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|Ras protein signal transduction|activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to UV|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|determination of adult lifespan|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|regulation of mitochondrial membrane permeability|replicative senescence|response to X-ray|response to antibiotic|response to gamma radiation	PML body|cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|protein complex|replication fork	ATP binding|DNA strand annealing activity|RNA polymerase II transcription factor binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|histone acetyltransferase binding|p53 binding|protease binding|protein N-terminus binding|protein binding|protein heterodimerization activity|protein kinase binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(467)|p.R213L(35)|p.R213Q(27)|p.R81*(21)|p.R120*(21)|p.R213fs*34(13)|p.F212fs*3(11)|p.0?(8)|p.R213G(8)|p.R213P(5)|p.?(5)|p.R213R(5)|p.R213fs*35(4)|p.F212L(3)|p.D208_V216delDRNTFRHSV(2)|p.D207_R213delDDRNTFR(2)|p.T211_S215delTFRHS(2)|p.F212I(2)|p.F212S(2)|p.R209_R213delRNTFR(2)|p.R213fs*2(2)|p.R213_S215>X(2)|p.D207_V216del10(2)|p.R213fs*32(2)|p.R213W(2)|p.K164_P219del(1)|p.R120G(1)|p.T211_F212insX(1)|p.F212fs*4(1)|p.R213*33(1)|p.R81fs*>11(1)|p.D208fs*1(1)|p.R213>L(1)|p.R120fs*35(1)|p.R81G(1)|p.F212Y(1)|p.T211fs*28(1)|p.R209fs*6(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)				48			31		0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903765	4903765	+	Silent	SNP	C	T	T	rs138268565		TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr11:4903765C>T	uc010qyp.2	+	0	717	c.717C>T	c.(715-717)gaC>gaT	p.D239D		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily T, member 1 (OR51T1), mRNA.	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D239V(1)		NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGCACTGACGTATTGTTTA	0.443000														117			23		0	0	1	0	0
COL8A1	1295	broad.mit.edu	37	3	99514923	99514923	+	Silent	SNP	G	A	A			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr3:99514923G>A	uc003dti.1	+	2	2309	c.2181G>A	c.(2179-2181)ctG>ctA	p.L727L	MIR548G_uc021xbq.1_Intron|COL8A1_uc003dtg.1_Silent_p.L726L|COL8A1_uc003dth.1_Silent_p.L726L	NM_020351	NP_065084	P27658	CO8A1_HUMAN	Homo sapiens collagen, type VIII, alpha 1 (COL8A1), transcript variant 2, mRNA.	726	C1q.|Nonhelical region (NC1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						CTGCAGGACTGTATGCCGGGC	0.473000														26			10		0	0	1	0	0
OR5M9	390162	broad.mit.edu	37	11	56230414	56230414	+	Missense_Mutation	SNP	A	G	G			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr11:56230414A>G	uc010rjj.2	-	0	464	c.464T>C	c.(463-465)cTa>cCa	p.L155P	OR8U8_uc001nit.2_Intron	NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily M, member 9 (OR5M9), mRNA.	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					TGTGCATATTAGGCTGACAGA	0.458000														186			4		0	0	1	0	0
DDX19B	11269	broad.mit.edu	37	16	70405336	70405336	+	Silent	SNP	G	A	A			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr16:70405336G>A	uc002eys.3	+	10	1377	c.1248G>A	c.(1246-1248)ggG>ggA	p.G416G	DDX19B_uc010cfs.3_Silent_p.G238G|DDX19B_uc010vlz.2_Silent_p.G384G|DDX19B_uc002eyv.3_Silent_p.G415G|DDX19B_uc010cfr.3_Silent_p.G265G|DDX19B_uc010vma.2_Silent_p.G325G	NM_007242	NP_009173	Q9UMR2	DD19B_HUMAN	Homo sapiens DEAD (Asp-Glu-Ala-As) box polypeptide 19B (DDX19B), transcript variant 1, mRNA.	416	Helicase C-terminal.				mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear membrane|nuclear pore	ATP binding|ATP-dependent helicase activity|RNA binding|protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|prostate(1)	9		Ovarian(137;0.0694)				ACAAGGACGGGAATCCTGACA	0.557000														187			10		0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22807259	22807259	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr18:22807259C>T	uc002kvk.2	-	3	870	c.623G>A	c.(622-624)cGc>cAc	p.R208H	ZNF521_uc010xbe.1_Non-coding_Transcript|ZNF521_uc010dly.2_Missense_Mutation_p.R208H|ZNF521_uc002kvl.2_5'UTR	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	Homo sapiens zinc finger protein 521 (ZNF521), mRNA.	208					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AAACCCACGGCGACAAATGGC	0.493000			T	PAX5	ALL									84			34		0	0	1	0	0
SPANXE	171489	broad.mit.edu	37	X	140785755	140785755	+	Missense_Mutation	SNP	C	T	T			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chrX:140785755C>T	uc004fbq.3	-	1	254	c.161G>A	c.(160-162)cGc>cAc	p.R54H		NM_145665	NP_663698	Q8TAD1	SPNXE_HUMAN	Homo sapiens SPANX family, member E (SPANXE), mRNA.	54						cytoplasm|nucleus		p.R54H(1)				Acute lymphoblastic leukemia(192;7.65e-05)					CCTCCTGTAGCGAACCACTAG	0.483000														499			8		0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79932729	79932729	+	Silent	SNP	T	C	C			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chrX:79932729T>C	uc004edt.3	-	40	5051	c.4788A>G	c.(4786-4788)aaA>aaG	p.K1596K	BRWD3_uc010nmi.2_Non-coding_Transcript|BRWD3_uc004edp.3_Silent_p.K1425K|BRWD3_uc004edq.3_Silent_p.K1192K|BRWD3_uc010nmj.2_Silent_p.K1192K|BRWD3_uc004edr.3_Silent_p.K1266K|BRWD3_uc004eds.3_Silent_p.K1192K|BRWD3_uc004edo.3_Silent_p.K1192K|BRWD3_uc004edu.3_Silent_p.K1266K|BRWD3_uc004edv.3_Silent_p.K1192K|BRWD3_uc004edw.3_Silent_p.K1192K|BRWD3_uc004edx.3_Silent_p.K1192K|BRWD3_uc004edy.3_Silent_p.K1192K|BRWD3_uc004edz.3_Silent_p.K1266K|BRWD3_uc004eea.3_Silent_p.K1266K|BRWD3_uc004eeb.3_Silent_p.K1192K	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	Homo sapiens bromodomain and WD repeat domain containing 3 (BRWD3), mRNA.	1596			K -> E (in MRX93; may be a rare polymorphism).							breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						GAGAtttctcttttgtttctt	0.408000														74			5		0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124819113	124819113	+	Silent	SNP	T	G	G			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr12:124819113T>G	uc021rga.1	-	40	6600	c.6483A>C	c.(6481-6483)gcA>gcC	p.A2161A	NCOR2_uc021rgb.1_Silent_p.A2145A|NCOR2_uc010tbb.2_Silent_p.A2154A|NCOR2_uc010tbc.2_Silent_p.A2144A|NCOR2_uc021rgc.1_Silent_p.A2144A|NCOR2_uc010tax.2_Silent_p.A275A	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	Homo sapiens nuclear receptor corepressor 2 (NCOR2), transcript variant 1, mRNA.	2165					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|Notch binding|histone deacetylase binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CGGGCAGGGGTGCGCTGAGCT	0.692000														11			3		0	0	1	0	0
CHID1	66005	broad.mit.edu	37	11	869923	869924	+	Frame_Shift_Ins	INS	-	C	C			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr11:869923_869924insC	uc010qwu.1	-	12	1319_1320	c.1206_1207insG	c.(1204-1209)gagctgfs	p.E402fs	CHID1_uc010qwv.2_Frame_Shift_Ins_p.E433fs|CHID1_uc001lsn.3_Frame_Shift_Ins_p.E397fs|CHID1_uc001lso.3_Frame_Shift_Ins_p.E372fs|CHID1_uc001lsm.3_Frame_Shift_Ins_p.E372fs|CHID1_uc001lsp.3_Frame_Shift_Ins_p.E341fs|CHID1_uc010qww.2_Frame_Shift_Ins_p.E372fs	NM_023947	NP_076436	Q9BWS9	CHID1_HUMAN	Homo sapiens chitinase domain containing 1 (CHID1), transcript variant 3, mRNA.	372					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		CCAACGCCCAGCTCCCGGGCCA	0.663													---	199	---	---	7	---					
MAP3K9	4293	broad.mit.edu	37	14	71206799	71206799	+	Frame_Shift_Del	DEL	A	-	-			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr14:71206799delA	uc001xmm.3	-	6	1650	c.1650delT	c.(1648-1650)cctfs	p.P550fs	MAP3K9_uc010ttk.2_Frame_Shift_Del_p.P287fs|MAP3K9_uc001xmk.3_Frame_Shift_Del_p.P244fs|MAP3K9_uc001xml.3_Frame_Shift_Del_p.P550fs	NM_033141	NP_149132	P80192	M3K9_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 9 (MAP3K9), mRNA.	550					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TGGGGCTTGCAGGAGGACTGG	0.552													---	344	---	---	7	---					
IRF2BPL	64207	broad.mit.edu	37	14	77493792	77493794	+	In_Frame_Del	DEL	TGT	-	-	rs28718623		TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr14:77493792_77493794delTGT	uc001xsy.3	-	0	1241_1243	c.342_344delACA	c.(340-345)caacag>cag	p.114_115QQ>Q		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	Homo sapiens interferon regulatory factor 2 binding protein-like (IRF2BPL), mRNA.	114	Poly-Gln.					nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						ctgctgctgctgttgctgctgct	0.700													---	4	---	---	2	---					
GPR139	124274	broad.mit.edu	37	16	20084858	20084858	+	Frame_Shift_Del	DEL	G	-	-			TCGA-KO-8413-01A-11D-2310-10	TCGA-KO-8413-11A-01D-2311-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a5a92196-b322-4ea4-8446-1844057de50b	9da1b142-030b-472b-861e-25be9ab226f3	g.chr16:20084858delG	uc002dgu.1	-	0	243	c.81delC	c.(79-81)ttcfs	p.F27fs	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	Homo sapiens G protein-coupled receptor 139 (GPR139), mRNA.	27						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						CCACGGGCACGAAACCCAAGC	0.682													---	113	---	---	7	---					
